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<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y3Z2</accession>
    <name>A0A0D1Y3Z2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_12091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847507">
        <property type="protein sequence ID" value="KIW09661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229877.1">
        <property type="nucleotide sequence ID" value="XM_016386398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y3Z2"/>
    <dbReference type="GeneID" id="27339174"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12091"/>
    <dbReference type="HOGENOM" id="CLU_844770_0_0_1"/>
    <dbReference type="OrthoDB" id="4119116at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW09661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="341" mass="39122" checksum="8D228803C2EB574E" modified="2015-04-29" version="1">MTTMLDLKLKQSLLILGSLSTLRGFHYEFGDMRLLEDLVQRDLEAWLPRVGTEDYGEFQDAQTAHSNSWKALTSEFVSVFPGAFPKDEEALKTLACQLRSQLRHTLERMSQLPDGREKTFLKPLQQFVCADLTWEMNAWLVLYSSAVIPSGDQFGSKLWNTRNRDWNQLAEFLGTSCLFSKPLTSRKLTATSLQDWIRKLESLFCGLEDHHIDSSEPINVAVFYVCEANDNEFIKHFRGLHCFATVGRNATSEAGKWLYRCILEKHESSVTEDDLIMNNRGPTYHKTFEDQSRAVQCWEDIVGNSKHLLDHRCPRPGPGSRAASDRPNVFKDIELFQAYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y504</accession>
    <name>A0A0D1Y504_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_11772</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230212.1">
        <property type="nucleotide sequence ID" value="XM_016386080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y504"/>
    <dbReference type="STRING" id="91928.A0A0D1Y504"/>
    <dbReference type="GeneID" id="27338855"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11772"/>
    <dbReference type="HOGENOM" id="CLU_004196_0_0_1"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000244">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="915"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="916"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW09996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1049" mass="118357" checksum="5B72A34719D41D63" modified="2015-04-29" version="1">MDLSKTIASTLSADANIRQQAELALKQAEQHHGFIGALLDNLQTEQDPGVRLSTAIYLKNRISRGWSTENTPHHPISEAERKPFKDRLLPVLSTSPPPVRAQLIPILQTVLQYDFPAKWPELMEITLQLLNTQDVNSVYAGLQCLLAVCRTYRFRAGEERANLDKVVNVGFPTLLGIANRLVNESSPEAGEMLRICVKCFKHAVYYGLPQPLQSHQATVDWCTLFLTIISKGPPESALDEDVEDRERNHWWKARKWSYANLNRLFVRYGNPSGLTTSQEKEYGDYARNFITHFAPEMLKVYLGEIEKWVGGNHWLSKPSLSYTLIFLEECVKPKAMWDKLKPHMDSLIKHLIFPVLCQSDEDLELFTDNPPDYLHRKLNFYEEVSAPDMAATNFLIALTKSRKQQTYVILSYVNEVVTRYEAAPDDQKNPREKEGALRMIGSLASVILGKKSPIADQVEYFFVRHVFPEFRSPHGFLRARACETMERFEQLDFKDPNNLMVIYRNILESMADPELPVRVMAALALQPLIRHDPIRIAMQSNIPQIMHQLLKLMNEVDVDALSNVMEDFVEVFAEQLTPFAVALSENLRDTYLRIIKEILERNEAKAAESGDGPGYGDYLDDKAIAALGVLQTIGTLILTLEATPDVLLLLETILMPVITITLENKLYDLYNEVFEIIDSCTFASKSISDTMWQAFELMHKTFKDGAELYLEDMLPALDNFVSYGQQRLINHPPYLAAIAGMVRDIFADPKVGGVDRICGCKLAEAMMLNLRGGPIDSFIPTFVTLPMEVLTGPQQKTIMKSYKIHLIEMVINALYYNPILALQVLEAHGWTNKFFSTWFGSIDSFRRVHDKKLCIAAIASLLTIRADQVPQSVQTGWPRLLTGATYLFRTLPAALKQREEAVKASDGVSDTLSEYASDDDAEDWADEPAGEQGQEWSNIDTEALPDTKGDIKDESQAYLDFLSEEAKKFGALADDDEDSILDEDSLLESPLDKFDPYGAFKESLGKLQTEQPQLYQSLTSILEPGDREVLLNVVAHAAQAQAQQTQAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y538</accession>
    <name>A0A0D1Y538_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230232.1">
        <property type="nucleotide sequence ID" value="XM_016386100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y538"/>
    <dbReference type="STRING" id="91928.A0A0D1Y538"/>
    <dbReference type="GeneID" id="27338875"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11792"/>
    <dbReference type="HOGENOM" id="CLU_006920_0_0_1"/>
    <dbReference type="OrthoDB" id="5423516at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="833"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1056" mass="117514" checksum="AABBF70CFCE667FD" modified="2015-04-29" version="1">MPALKHLVCNVQWEETGAPFPEYGTQYGDGFVETFIAIPNHPQPFSIRLSSRRFIHEGLAMLVYIDGKYQCNRIRVNLKSPRGALPETRSKIDFVVRQKETRLGDGAYMAREWRFDDYNIVQQLPPGASESHFESLGTIEVFVLRCNSNIPGEFDALSDSSKEDSVIMEHYERQTSGVQSTRTVAEPDFEGFPFAGLFDGPSNLPSSSRFLQVDGPADDHDYWDYRYRYGPAPYPPQERPAYHSHEHEHERVPDGTFYYRRPTPPTSPSPPNRGRDQPDHLPPRRERRVHFDYGTAREGPMYNDRHQSQRTPRYHHDYYPAQHYVGHHPEGDYPSRHLDIPYRNRDDGPRDYRDYPEPPMARGALRVPLASASRIPGLSEHRATLPNHTRMDSAAAAAAAAAPAPMPYTAVPPFAGQHQLPMQPWLGQPHPVFPPSMPGPTPIFPYLLHNNVPWFQAANQSGLQNTHSATNKDAAKQDASSTATSATAKAEPSAPASKDSDNNATNNTSDNSNTQNQGGSDNNTNKPEQNQSNSADKGTSNENYSQEWNEWQNGGSNDNTNNNTSDNNNWENQNTNDESRDQNNIDESWKGNNDTSDDNKSNLDESWKNNNDTADDNKSNKSNRDLSQEQNTSSNAQNVQVSTSNASGKMAWYGPHGLYQVAKFYRDASIPAIAEEEPRYDVPQAVAQAIGVTKQVQPGRGYVYSKKSVHPAEYLDTLQDPYARFIFKYRHREQIKTETGIDISSDPTPDADRNSLESKTKDELIELVLRAKGALGGTIPDPPKPKPVAPVVSAPLEHIPIAAPQHPFPSYYLPTFRRPSGTGSGSGVAQPPANTATTATAAAADDGWGSTNANSSVAEGKQKNNKNKNNNWQQGGEAQGWNDQQAPNTSSWDGQNEEEPLQRDQPNQTQPTETNKPASSGISPLALPGPSYRASIPVESRVWQDQDQDAPPPTTPRTSASSDMVRSVPLTDPFGPSEPPRRLTEEEEFEKGVGEPPPAGFTTWYRYFMHPNSPDIPSEYVREEIVDAPDRPPDPVRARAPSPPRLAPGEPHDFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y5E0</accession>
    <name>A0A0D1Y5E0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230362.1">
        <property type="nucleotide sequence ID" value="XM_016385418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y5E0"/>
    <dbReference type="GeneID" id="27338190"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11107"/>
    <dbReference type="HOGENOM" id="CLU_036632_1_0_1"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="45"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="405" mass="44277" checksum="33211ECCCBA3825E" modified="2015-04-29" version="1">MADSTSETPVYGPRPYGLTDDDHRGVVLTMTILFMVYAGMVLAMRLIVRYRNMGVEDWLSLAATSLAFPQFITILVATVDAGFGASFSLLSSDDTTIVARCIRAADVLFLLALFVSKCSVIWFCRRLFTVSGHKMPIITEVAMGVCATWCLGSILGVTLGCDSIAMIHARDGRKCGTLVSRWAAVGALDAVLEIGILVLAVGVISTLQMTWKMKLQASMCFILRLPIVVLIGLNIKYVVRFNSASNAGMALVSPVLFRQAELFYALLSAAIPSLNQYLRKFDTSHATHYGYRSTADESRGNTYQLDSMPNGRSKSKNRNWNRSKSTPTNASGEAYDAEEFGKSTNVQFPATGYSGYQAQVQGPRNSKANDGNSTGSQEDVSTGRAGSEDHIIRKNVVYEVRHEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y702</accession>
    <name>A0A0D1Y702_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230882.1">
        <property type="nucleotide sequence ID" value="XM_016385938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y702"/>
    <dbReference type="STRING" id="91928.A0A0D1Y702"/>
    <dbReference type="GeneID" id="27338713"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11630"/>
    <dbReference type="HOGENOM" id="CLU_055874_0_0_1"/>
    <dbReference type="OrthoDB" id="187522at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264:SF1">
        <property type="entry name" value="INOSINE_URIDINE-PREFERRING NUCLEOSIDE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002246709" description="Inosine/uridine-preferring nucleoside hydrolase domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="355" mass="38242" checksum="DF1A0B5952359EE1" modified="2015-04-29" version="1">MGISISTAVLLLCWLANATAAKATKGQGQPIIIDTDLFGDVDDVGALTIANVLHNCGLADLRGIMINTPSQYGAPAASAICSYFGNKNVPVAALRPITNASFFDDWEYVRGEYASKIAYNWPGSLTNASLAPTPVELYRSVLASAENSSLHIISIGFLTNLADLLRSEADDVSPLTGTELLEAKVSELVVMGGRYPSGWEYNFGGTDPNSTTYVIEHWPKTVPVTFSGGELGSTVFSGQRPLEESPSDSLPVSAYQWYVGRGSVTREAWDPITVLYGILGLDNFTKLGVWPMLAYANEYGYNTITASNGSNAWVNDTSVRNQHWLKLADGVTNTSMAWLVDNFLVHPPGLSRCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YA28</accession>
    <name>A0A0D1YA28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_09078</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232022.1">
        <property type="nucleotide sequence ID" value="XM_016383399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YA28"/>
    <dbReference type="STRING" id="91928.A0A0D1YA28"/>
    <dbReference type="GeneID" id="27336161"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09078"/>
    <dbReference type="HOGENOM" id="CLU_049366_0_0_1"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="248"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="337" mass="36916" checksum="649BD96994C2FC99" modified="2015-04-29" version="1">MDIPADVGFDYEPELPIAISQVGGRHLLFDIKVATFLRREHRICGTQTGTLPLAPSQNLFLGLPIEIMPEEAQLLVDKGVAVVVDDARAHDQAVLRCSSSDGARRADYLASLDKQARRFEKLSMQEKEQSRQRALERRAKASTRQPSSAESTTPRRRGEAASSLLDLADADEEEQQQEEEEAAASTAPTLGENSARHEPVSSQTPPDSTSEQPVSSASNYHITPATSQPLLPDVADAPRSTVQDLPASYPMYKHLHERGYFMTPGLRFGCQYNVYPGDQLRFHSHFLASAFEWDEPIDPMDVVGGGRLGTGVKKGFLLGGADPAGQVRTFSVEWAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YA39</accession>
    <name>A0A0D1YA39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease P protein subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_09089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232032.1">
        <property type="nucleotide sequence ID" value="XM_016383409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YA39"/>
    <dbReference type="STRING" id="91928.A0A0D1YA39"/>
    <dbReference type="GeneID" id="27336172"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09089"/>
    <dbReference type="HOGENOM" id="CLU_078577_0_0_1"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027081">
        <property type="entry name" value="RNase_P/MRP_p29_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR027081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="289" mass="32083" checksum="7A601CA7CF4742D8" modified="2015-04-29" version="1">MTSSPKTTTPATGAVSHPAHALLSRAHSPDTASRIFTDKVRNKPLLLQPTSSSDRDKRALRRHIRLRKKEYHLRKRKPRPLSAKEKRDTGVFKLHKDEIKYDVYVKLHELWNAYMLEVLGYTKDGEAVEGRLGKTLTAQGGAGGLLASADFHGAMLEVVSATDVGKVGLRGIVVRDTKYTFVLVTERNKVKTVPKRDCVFRYRVDLPRLPGGEDTGAKENEDGPEKDEDGKEGAQSARGDAKSKAQAEASGARAGTGRSVTFEVHGNQFEFRPADRASRKFKWKVTDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCY1</accession>
    <name>A0A0D1YCY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233042.1">
        <property type="nucleotide sequence ID" value="XM_016382339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCY1"/>
    <dbReference type="STRING" id="91928.A0A0D1YCY1"/>
    <dbReference type="GeneID" id="27335096"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08013"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="266"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="529"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="633" mass="70225" checksum="508E565A359641A7" modified="2015-04-29" version="1">MVFSSPAFTPPLPEVPDTLPLCDFMFDERYGRCPVSKSLDPYTCGITGKSISAKEQKVRVEYLARSLAHEFGWNVNGGTEYDKVVGVFATNTVSHRSLQLNDLPNRCASLEADRLLNVKIDIMTLNWAIHRINGVSSPANAAYSVEELRHQLEFSGCKALFTVEPLYSIALKAASLAGLPRDRIFLCDVPGQKPTPSTHKTLSQLIEAGRLLPELEPIRWERGQGSRQTAFLCYSSGTSGLPVGLTTSWTRAFTSKSQLTRCCCEQKAVMISHRNVIANTMQTCLYEKASRDAISPDYRDVGLGLLPQSHIYGLVIIAHASTWRGDQVIILPKFELKSYLNAIVRFRINTLYLVPPIAITMANNEGLLKRHDLSSVRQIFSGAAPLAKEIADALLDRYPRWKIRQAYGLTESCTVVTSTSHRDIWPGSSGCLLPGCEVKLIDTESGEAITEHDRAGEILVKSPAVVLGYLKNQIATSETFVDLPEGRFLRTGDKGEFRRAPNSGNEHLWIVDRIKELIKVKGFQVAPAELEAFLLNHPAVADCAVISIVDQDGCESPKAYIVKSQPALTRNVSDTALAREIQQYVEDGKARYKWITGGIEFVDTIPKSPSGKILRRLLRDQERERRRVAGARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YD56</accession>
    <name>A0A0D1YD56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233107.1">
        <property type="nucleotide sequence ID" value="XM_016382404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YD56"/>
    <dbReference type="STRING" id="91928.A0A0D1YD56"/>
    <dbReference type="GeneID" id="27335161"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08078"/>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="135"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="479" mass="53643" checksum="4850ED36BED85717" modified="2015-04-29" version="1">MTTTALPAETALRRMGTTESTPMSSTNISPLDSPRSSPSSTSLSSLASEDALEQKKPVVGKKQLVDTYGNTFEIPDYTIKDIHDAIPKHCFDRSAATGLYYVARDVVSLATTFYLFNRFVTPETVPSTPLRAGLWFLYTVVQGLFGTGLWVLAHECGHQSFSKSKVLNDTVGWFCHSALLVPYFSWKISHGKHHKATGHLERDMVFVPATRQEWATRRGYLLHQLDELTEETPLNTAYTLISQQLGGWPMYLLTNVTGHNKHEGQREGRGVGKHNGFGGGVNHFNPNSPLYEAKDAKLIVLSDLGLLIMGAILFWVGKTYGFSNLFVWYLAPYLWVNHWLVAITFLQHTDPSLPHYTPTSWTYTRGAAATIDREFGFIGRQLFHGIIETHVLHHYVSVIPFYHADEASDAIKKVMGRHYRSDTRGGPIGFIKSMWNSMRWCQWVEPLEGTTGDEAGVMFFRNRNGLGLPPAKLEKAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDK6</accession>
    <name>A0A0D1YDK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF3824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233292.1">
        <property type="nucleotide sequence ID" value="XM_016382589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDK6"/>
    <dbReference type="STRING" id="91928.A0A0D1YDK6"/>
    <dbReference type="GeneID" id="27335346"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08263"/>
    <dbReference type="HOGENOM" id="CLU_013056_1_0_1"/>
    <dbReference type="OrthoDB" id="5407645at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="76731" checksum="AB6A273262FE42D7" modified="2015-04-29" version="1">MSYYGDDNRPRRAKSTRERSRRDDYDGGTIYDENVRDTRIVRRRDDSVSSVEEISRGDVEPGSAYYRETTVRKSGHRPVRTRSDDDRWYDDRYDDSTYVSRRRRDDEYTVAGGRSRRGKDHDDRHRSHRRDDSYDSYSSRSRTPEKKKERRKSTTEEVLGSLGLGGLAGAVLGKSRDRSRDRDSDRSRHRSRSRAGGRRRSSSETSRHRSKSRGKASKNEQYSQAIKAAVLAGASEAFRSRKEPGGWGGNKGKRVLTAALAAGGVDGLISNKDDPHHHNKRDIVGSAIAGLATNRIINGARSKSRGRGGSPDSRGRSRSRGGIGDLAAGGVVAATAKKVYDSVRSRSRGRARSRDSSYDSRYDSPPRQKRSRSVSRVAAKGLAALGLKDAADKVDPERRSSSRHYDDYYDDGRSSRNGGYYNDSRDVGTTQPQQNHPRDRLRSMSLPRGHPPGYELDYGPRHTGDPDTDTDSDLGSSSEDEKRLKKGKKKMLLTGGLATVATIHAAHNVYQSMEKREARRKALREGDISREEARREKNKARLQDAASIGIAALGLKGAYSEWKETQEFNRQRREEEEKIERHARKREARRRKMSMLATNDYVNSNYTGSMPNLNTYSQEVYHPNGAHAPFASTSEVHYTDDNPYGAMSQTAVQYAAPPPAPPGPTPSTGFPPPPIGVPPPGGHYPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YE17</accession>
    <name>A0A0D1YE17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233547.1">
        <property type="nucleotide sequence ID" value="XM_016382844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YE17"/>
    <dbReference type="STRING" id="91928.A0A0D1YE17"/>
    <dbReference type="GeneID" id="27335602"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08519"/>
    <dbReference type="HOGENOM" id="CLU_068979_8_2_1"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF16">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="206" mass="23127" checksum="262ADFC9D275686F" modified="2015-04-29" version="1">MSQRQALVLIDPLNDFLHPQGKLYPALEESLETTGTVDNIRQLVQGARSGGIPIYYGLHQSYKEGHYDGWLHMRASHVRNKDKHVFAGWGGEIMSGFEPRLDNGDVVVSRHWNSSSFANTDLDYQLRQREITHLVMAGMVANTCLEATARHATELGYRVTLLKDSTAGFSSELKAAGEFVWPILFEQVMTVKEWVATVRQGQPAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YFZ4</accession>
    <name>A0A0D1YFZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_06732</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234167.1">
        <property type="nucleotide sequence ID" value="XM_016381065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YFZ4"/>
    <dbReference type="STRING" id="91928.A0A0D1YFZ4"/>
    <dbReference type="GeneID" id="27333815"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06732"/>
    <dbReference type="HOGENOM" id="CLU_026724_0_0_1"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="553" mass="61349" checksum="354C65678C77A3FA" modified="2015-04-29" version="1">MAHQGQAADYYNNQQQYAYQQYAPPPGPPQGYQSYPPPDAHPQNNQQQYQPPQQPYQQPEQKYSQPPTSGVQFNAPQDEKQTFQDTFKIQKPKYNDIWAALLLIATFCGFVAVSGLTLYRYSKYHQFNGGGIYGSANDFSLNSNTIILFAFVLAVGFVVSWAYFLAARAFTKQFVWLTGILNCVVAVGTAAYYLYRRLWGAGIIFAIFAVFAIICFISWIPRIPFAVCMLQQGMDIARMKRVHVFMVSLIGGIVSVAFAAWFSVTLVAIYVSYEPSNPGANPNPSCADGGCSSGKVIGLVVFVTFAGYWISEFIKNLIHTVVAGVYGSWYFCAGKPGGIPKGATMGAFRRASTYSFGSISFGSLIVAIINMLRQACSIAQQHEAAEGNIIGTIMYCILGCMISILNWLVEFINRYAFSHIALYGKAYIPAAKDTWKMMKDRGIDALVNDCLVGPVLTMGSIFVAYLCALLAYLYLEFTKPAYNDGRTFTPVIMAFAFLIGLQICQTFMTPIGSGVDTIFVAMAWDPQVAMTDHPEFYQRLVHVYPRVQDVIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJ43</accession>
    <name>A0A0D1YJ43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235172.1">
        <property type="nucleotide sequence ID" value="XM_016382070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJ43"/>
    <dbReference type="STRING" id="91928.A0A0D1YJ43"/>
    <dbReference type="GeneID" id="27334826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07743"/>
    <dbReference type="HOGENOM" id="CLU_030273_3_2_1"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000003">
        <property type="entry name" value="D-galactonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="6">
        <location>
            <begin position="150"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="407" mass="45202" checksum="DEEF8B607F4B0F8E" modified="2015-04-29" version="1">MATDQLKTLAGKPSGSQPSIPGAPSAKIKSIEYFRVKPRWLFVKICDDQGNHGWGEATLEGHTKSTEGALDEIIDRIIGYEADDIEHIWQTIWRLGFYRGGPVFMSALSGIDIALWDLKGRKLNVPIYQLLGGKVRNKVQVYAWIGGDRPSDIETAAKARIAQGLKCIKMNATEDVNWLDSPSVLDSTIERLKTVKALGLDAGLDFHGRLHKPMAKQLAKALEPYRPLFIEEPLLVEHPEAFKQLSQLTTVPIATGERLYTRWDAKRLLEDASIDILQPDIAHAGGISETRRMATMAETYDVAIAPHCPLGPIALAACIQVDLCTPNFVIQEMSLGMHYNVEAGEEDLNTYLVDQSVFKIEDGYIKAMTGAGLGIEIDEDVVRKISKTTKPWQCKEFYGPDGSIREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPP7</accession>
    <name>A0A0D1YPP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237402.1">
        <property type="nucleotide sequence ID" value="XM_016378725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPP7"/>
    <dbReference type="STRING" id="91928.A0A0D1YPP7"/>
    <dbReference type="GeneID" id="27331460"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04377"/>
    <dbReference type="HOGENOM" id="CLU_009938_0_0_1"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="134"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="5">
        <location>
            <begin position="671"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="417"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="528"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="85105" checksum="E84BDCBC373AD849" modified="2015-04-29" version="1">MYNPYQAPGQYGIPGDYGSVSGAPPGMAPPPGMTAPGTGAPPGMQPQEAHQPGRPGSFPSNFQPPPNMPNINFSAPVIRLGTSGPTKPESGRDERDNRGGRRAGLGSGMGSEFRGGDRDRITQVQPQTKEEIIKTIFVGGITEGTGGDEGIERILRSAGSLRRWIRATDADNKPCKFGFAEYEDPESLGTAIEILRDVEVPVKRQSPQEANGDEEISVEMSKLIIVADDNSLSYIEQWEESVGGKDPEQAQMRLDHARDALAAVLKDLSNPTAPIQKDEMSSIDKEGDVSMVDGQAEAANGDVVTIPINVDDELSDIPAEMRETVAREIAAFRDRSNRRDLERLKREEEIEQQERNRIMNGDRYNRLASPPPSAPSGPGGSNGIPVGPKGAPAGPKAYGAQIPKDYQKGVTFVNGTAINGASAFEDEDTDASDEELERRRQAKKDAELEKQYLDQERRWLNRERSRTAAVEREKTRDKDDSTRLDAAKEAMAKRLREWNDDVEASRKTEEYYADKSLWIRNRASFRQREMAHDEADRAAEHRERARQNQQRERAGAMADDFLNRQEEEMNRQEQEEDDERPQTSRREPARFKLSLGAAAQKAAAQTAQQATKRTVAEVEGLLEDEEEDSKAGGRRTLIPIQYDASATSTMTEEERAQAARQLAADIPNDKDGLWNWEVKWDFVDESVIDERLKPFVEKKIVEYLGVQEQMLVDYVVNALQSRGKPQDLVGELEGALDEEAEVLVRKLWRMLIFFSESEKRGLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPY8</accession>
    <name>A0A0D1YPY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phytase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237507.1">
        <property type="nucleotide sequence ID" value="XM_016378830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPY8"/>
    <dbReference type="STRING" id="91928.A0A0D1YPY8"/>
    <dbReference type="GeneID" id="27331565"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04482"/>
    <dbReference type="HOGENOM" id="CLU_020880_3_1_1"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="32"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="49416" checksum="D2F9E46D770A5655" modified="2015-04-29" version="1">MWHLFYHLGGNGPWIPRVSGIEYSNASLPKHCSVDQVHMLSRHAERYPTKNAGARHFDLLDRLKKPGVDLTGALSFVKSWKYFTNPEDPAFENLTATGPYAGTRQAFNTGTMLRQTYDHLVPPARRTKFWSCSSGRDIETARNFADGFFGSDWDSHGSAELVVIPEDANRGADTLTPGSTCYKYRRDGYGHDYGYGKLELWQKVFTKPIIDRLSQHAQGVQIDHLDVYSMMEMCGFEILAKGSSPWCAVFTQDEWLHFEYARDLLHFYRAGPGNSYAGAMGWLWLNATQTLMSNQSSKDVYFSFVHDGDIIPVMATLQILNEQVMLQELPTTHMKTDRRWRTSDVVPMGGRLIFERIACQTGSETAGMEHFVRLFVNDGLMKLPGLRATKHIEHGVRLDDFQDFVSSRKQIFGDFREVCSLPEDSPDRISFLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRH6</accession>
    <name>A0A0D1YRH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol glycan, class U</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238077.1">
        <property type="nucleotide sequence ID" value="XM_016379400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRH6"/>
    <dbReference type="STRING" id="91928.A0A0D1YRH6"/>
    <dbReference type="GeneID" id="27332139"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05056"/>
    <dbReference type="HOGENOM" id="CLU_030193_0_0_1"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW17861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44220" checksum="9C414C4D44D3F651" modified="2015-04-29" version="1">MTSAWDRKTIGIYAGAICLRLLVVFAFPDLPNFLSTQVEISTPVSSFKRLQEGLFLYQHGLSPYDGGVYHQAPLLLVIFEILPSTLVFVSLDVLNAVALQTIADNLRIPTPRFKDLDGSLIAAAYLFNPFTILSCLGKSTSIFTSAAIIQAILNAQSGNALRAMFGLAIGSYLSMYPALLLPPTLLMIHQSAGKSAPLSVSVAAFVGAFAALLGTTLVLTDSFEDFLASCYGAQITVPDLTPNVGLWWYFFIEIFDSFRDFFIGVFWLHLVGYVGGMTLRLQNQPLFVITSLLGLIAIFKPYPSIADVSLYLGFLPMYSHVLPLTRYTFIAASVLLYSTLLGPAFYHLWIYAGSGNANFFYAITLVWSLGLCILVGDTLFAVMREEWELERPEMTGKAVRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YS55</accession>
    <name>A0A0D1YS55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">PV08_02338</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238267.1">
        <property type="nucleotide sequence ID" value="XM_016376697.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1YS55"/>
    <dbReference type="GeneID" id="27329421"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02338"/>
    <dbReference type="HOGENOM" id="CLU_000422_8_0_1"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="26">
        <location>
            <begin position="53"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="2116"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="2125"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1183"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1189"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1194"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KIW18051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="2150" mass="237899" checksum="DA25BA1F4F43279D" modified="2015-04-29" version="1">MGLPTVDSHKQENETPEVQEEYTPYQPEKGYGWGEALPEKQGLYDPSLEKDACGVGFAAHIKGKPSHKIVSDARNLLCNMTHRGAVGSDARDGDGAGVMSSIPHKFFVKNFAREVGVELPPLGQYAAGNLFFKPDTEMLKHATLSFEEAAQSLGLRTLGWREVPRDSTLLGPAALSREPIILQPFVVLASAYGTGNKPDITDPEQFDDVEFERKLYILRKTVSHDPRWKPWFYVCSLSNRNIVYKGQLAPVQVYQYYHDLVSVDYEAHFALVHSRFSTNTFPSWDRSQPLRWLAHNGEINTLRGNKNWMRAREGVLKSDLFGEDLEKLFPIVEDGGSDSAAFDNVLELLVMNRVLSLPEAVMMMVPEAWQGNTAMDAGKAAFYEYAANLMEPWDGPALFTFSDGRYCGANLDRNGLRPCRYYVTDDDRIICASEVGTIAIEPERVIIKGRLQPGKMLLVDTQAGRIIDDAELKATVANRQPFQQWLDKNLMKMPQVYEALSKEADLSSKLTESSVQEDARLKAFGYSFEQVSLLLAPMAADSKEALGSMGNDAPLACLAQQPRLLYEYFRQLFAQVTNPPIDPIREAIVMSLECYVGPQGNLLEMDESQCGRLLLPSPILETETFNALKNINLYNKDWSVRTIDITFEKSAGVDGFMNALDSICDSATAAIEEGDKIIILSDRATSADRVSVPTLLATGLVHHHLVRNKWRSRAAIIVETAEAREVHHMCVLLGYGADGINPYLAIECILKLNREGIIKKKLTDQQLIANYKASCDGGILKVMSKMGISTLQSYKGAQIFEALGIDDAVVDRCFAGTATRVRGMTFELIAEDSFAFHEQGFPSRHVRDIPGLPETGEYHWRDGGENHINDPVSIANIQDAVRTHNDKSYEAYSLSEYEQIKNCTLRGMLDFDFDQRQPVPIDQVEPWTEIVRRFVTGAMSYGSISMEAHSTLAVAMNRLGGKSNTGEGGEDPERSLKMENGDSMRSAIKQIASGRFGVTSNYLADADELQIKMAQGAKPGEGGELPGHKVSEPIARTRHSTPGVGLISPPPHHDIYSIEDLKQLIYDLKCSNPRSRVSVKLVSEVGVGIVAAGVAKAKADHILISGHDGGTGASRWTGIKYAGLPWELGLAETHQTLVLNDLRGRVIVQTDGQIRTGRDVAIACLLGAEEWGFATTPLIAMGCIMMRKCHLNTCPVGIATQDPLLRKKFQGTPEHVINFFYYIANELRAIMAQLGFRTVNEMVGRAELLKVREDLRSRKTENLDLSLILTPAHSIRPGVATYNVRKQDHKLHTRLDNKLISESELALEKGLPCRIETDIVNTDRTLGATLSYHISKRYGEAGLPQDTIHVNIRGSAGQSFGAYLAPGVTLELEGDANDYVGKGLSGGRLIVYPPRSAVYKAEENILIGNVCLYGATSGTCYFRGVAAERFAVRNSGANTVVEGVGDHGCEYMTGGRVVVLGSTGRNFAAGMSGGIAYVLDMNQDFHSKINMEMVEVSGVDDPSEIAFLRGMIEDHHHYTGSELAARILLEFNRALPRFVKVLPTDYKRVLLEQAKKAEEAKKAEYPLPILPGNPVRNLHQEQRDAAHEKEAKQKKAEMLDIEEGINGDADKAKQKAALVLDKTRGFMKYTRRSEKYRNAKTRVKDWAELSSRLNEDELKYQSARCMDCGVPFCQSETGCPISNIIPKWNELVFQNQWKDALNRLLMTNNFPEFTGRVCPAPCEGACVLGINEDPVGIKSIECAIIDKGFEMGWMVPTPPAERTGKKVAIIGSGPAGLAAADQLNRVGHSVTVYEKSDRCGGLLMYGIPNMKLDKRIVQRRVDFMAAEGVNFVTGVMVGPGEEITLESLRKSNDAVIISTGAQVPRDLKIKNREAEGVHFAMEFLHANTKSLLDSELGDGKYISAKDKHVIVIGGGDTGNDCIGTSLRHGAKSITNFELLPQPPPERARDNPWPQWPRIYRVDYGHTEVKQHYGKDPREYCVMTKDFVMEDGRVVGINTNRVEWTKSATGAWEMKPKEGSEQYFPADLVLLSMGFLGPDDRLFESEIELDPRKNIKTPKNMYNTNIPGVFAAGDCRRGQSLIVWGINEGRQCARQVDSFLMHTGSVLPVTGGIVRRAQHDSVPPPRESKAHKQGDMAHASEEMKRVPEIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YS58</accession>
    <name>A0A0D1YS58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238272.1">
        <property type="nucleotide sequence ID" value="XM_016376702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YS58"/>
    <dbReference type="STRING" id="91928.A0A0D1YS58"/>
    <dbReference type="GeneID" id="27329426"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02343"/>
    <dbReference type="HOGENOM" id="CLU_026974_5_1_1"/>
    <dbReference type="OrthoDB" id="124329at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30006:SF2">
        <property type="entry name" value="ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30006">
        <property type="entry name" value="THIAMINE-BINDING PERIPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13343">
        <property type="entry name" value="SBP_bac_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237172" evidence="2">
        <location>
            <begin position="20"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="358" mass="39584" checksum="A00A675EE31A532C" modified="2015-04-29" version="1">MRYSIFATSALLLAGSSCGAVIKAITPDVDTRNISEIYAAALQENGTLQIAYGGDEKKQSTAFVQAFQAAFPGININATTDLSKYLDGRINRALLAGETYADVAIIQTLQDFDSWKARGVLLEYKPPGFHQLYTAITDPDGAYIPANIGGFGYFTYDTTRVSAADVPKTYLDVLDPKWKGKIVLTYPNDDDAINFLFATIVDKYGWQWLEQLLTQDVRWVRGTATPAEVIAQPGSQYELTFSGYRAAANQSMAAPQDYFMSWAQTSAIFKSTKLPETAKLVQAFLASEDWQTAKVAQGSFSTRKDVSANSTVWAAEWTDAARYHQFMVQRDVVEAWRFNFEDYLGTAQGLSPLVDDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YU43</accession>
    <name>A0A0D1YU43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AHC1-like C2H2 zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238997.1">
        <property type="nucleotide sequence ID" value="XM_016377427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YU43"/>
    <dbReference type="STRING" id="91928.A0A0D1YU43"/>
    <dbReference type="GeneID" id="27330153"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03070"/>
    <dbReference type="HOGENOM" id="CLU_016272_0_0_1"/>
    <dbReference type="OrthoDB" id="5355528at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058706">
        <property type="entry name" value="zf-C2H2_AHC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25909">
        <property type="entry name" value="zf-C2H2_AHC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHC1-like C2H2 zinc-finger" evidence="2">
        <location>
            <begin position="297"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="656" mass="70859" checksum="97C0E2E75C24C053" modified="2015-04-29" version="1">MLRLLSWTGCDKAASPEMRMFVPKQDSPASGAITMPPKHKRKQSGDNQDQSERKRAKIVEKNNSKPSSLVSALAPPVEVQTMNASPTMDGIPPSLSTPPDIKTEDSELEHSTGANTGATSIEDDKVATKRLDPLRNVIQTQLSLEILLKHKELRLIDQEIAKCQASLEQLRRCKEIPYPATQQPSLAVSNGTGAALRKGFPMPLPQSPPPWGVTDGPYARHYAKWLLPDARFDGGVDPEPVGRIPTGKSPMKFRSMRGSFEAPSASSSSRSNRGGKLKALPPGYGQPKEKATGPMIVKRKSDGLTVKLVCPDCGRHDFGSAQGFINHCRIGHGRSFASHDAAADACGEPVEVDESGAIVGAEPTATPTTGNVHPLIRSAKLLQPTPPKAYTQNTAPAPTAKSVSPNFKESALTPNLSDLVKSRGFGIDLDMLVTEAKTKVELSDVESDEEEDIDIPVQTAGQGRHPQVAMSKQPPKPTKSPMSSPLLSTSMTRTPNVRRNAIPQYDGAADDFIQHRPRGIHLPMTHSAGTDLQPSDPSPTSESNQAPSLVDDDEEYEAHSPTSSSVSDEHDDGEVVFEVQGDDDDARTVLHAPEFQGSQPGCAQPARPATHARRPSAIRRHGEDREEKHVSFVSPSPARDMPMGRQSADRKKRKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUX8</accession>
    <name>A0A0D1YUX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Crh-like protein</fullName>
            <ecNumber evidence="15">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_03356</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="15"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239282.1">
        <property type="nucleotide sequence ID" value="XM_016377712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUX8"/>
    <dbReference type="STRING" id="91928.A0A0D1YUX8"/>
    <dbReference type="GeneID" id="27330439"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03356"/>
    <dbReference type="HOGENOM" id="CLU_040459_0_0_1"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000159">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002247282" description="Crh-like protein" evidence="18">
        <location>
            <begin position="19"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="19">
        <location>
            <begin position="58"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="346"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW19066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="446" mass="46181" checksum="66EBFD0E895DD7A5" modified="2015-04-29" version="1">MAGRFWLLAASLAPAAYAAVTCGGGKQCPEDTPCCSQYGQCGVGAYCLGGCDPVNSFSLQACTPAPVCQSKTYTFDNLDGIQSNTKYLGDPSKADWVSSGQPLEYNGSVLLTMAEGTVGTLLASTDYVWYGKVSARLSTSAGAGVVTAFILLGDSKDEIDFEFVGVELESAQTNFYSQGVTDYHNGGNTTGLSDVHLNMHDYEIDWQPDTITWSIDGNVVRTLNREDTWNATANRYSYPQTPSRVQLSLWPGGLSTNGEGTIEWAGGLVQWDSPYMENGYYYATFDEVSIECYDPPSNAQKNGTKSYIYTNDAMTNNTVEITNENTILSSFLATGLNMTAGEASASASASGSAKTSDVETVPGLSGGGTGNNGQRGDGSSASSSAAGTDAGSGSATATGSASTGFVQGGGSDSNNNGAGQLGGNSETVLRGSLLAVVVAVVGLCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVB8</accession>
    <name>A0A0D1YVB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239447.1">
        <property type="nucleotide sequence ID" value="XM_016377877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVB8"/>
    <dbReference type="STRING" id="91928.A0A0D1YVB8"/>
    <dbReference type="GeneID" id="27330608"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03525"/>
    <dbReference type="HOGENOM" id="CLU_004692_1_0_1"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="847" mass="93678" checksum="5B97EA3181C2FA83" modified="2015-04-29" version="1">MDILTRLIAGSGTSPTKQKTNTPAERLATCKSICNALTQAWRGGAVEREEESALTYTAKLLQRLENILHDESRRAAPHSCLRYVASSQAYIIITKLAVSSRNTEIIKLSAQLFHILINGEAEGLLDSKLFTRSLLDLVCYATIGGQVIVEERLETDLVELLFEIATKIRLDPDILPAWFYPDRENTRGRNGIDETRRSQFPLFFVLVQYVHHDGPVGDFARTALLYLTETASRFKPLETWMIESDLAPQMASGLGALYSRLSRQSTSLAARSSKLAIVTLSDYSETVDSLAESPRDSPQAVKAFFSYLAFWQDTLNHCKSLEVSDTLLDHFQVLFVQQLLYPSLLESSDVEGGSTAAVITHLSRMLLAVDHYQLIDRMLGYLLASPHTPRVSRDKSHRRQRMSVSRSKSIEQLKALSETADSPSPNLFNLLDLLVMSLKSSHSETVNACLKLLSVIIGKHHCHVPLILFRTEVASTQSVRSGVDALNAYLHKLFEYSGAVGKDHLDNELDQSYQDALQDCQVLLEQHSCFVTAPADADLVNGNSMTIAPECKLFEALTQLLRNFFANDSVTNLYLTEALVALTACEYMDLQGWLLPGAQGRLEEHSAYNITFILSELADQATQWKSQFPQWDELMSLRRHELSEDAPEQPANPRTSSGQTAGSTMRTRSISPPKAQSRPATPRGRPIPPTEFGSIDSKLSGSGSHRADLAERALGRSPLRQALPTDGTDGLTAAPEAARPITPSTTSLLRTQVDIYNTKTPTEATASLPVHAGRKQDPEADALPFRPSLTQAHDSGTATPISRDDSEPRHQATLNHILTNAVILQEFILEIAAIVQLRATFFDEISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVP3</accession>
    <name>A0A0D1YVP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239572.1">
        <property type="nucleotide sequence ID" value="XM_016378002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVP3"/>
    <dbReference type="STRING" id="91928.A0A0D1YVP3"/>
    <dbReference type="GeneID" id="27330734"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03651"/>
    <dbReference type="HOGENOM" id="CLU_024070_0_0_1"/>
    <dbReference type="OrthoDB" id="5431013at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="71538" checksum="107B2F927370A829" modified="2015-04-29" version="1">MAETGTSLTRHLESRSDPFVAGTIASILGVAGAGFRLSLILNAISCEIVNAGFEVHGISKGVTLFSTMLKQTGVVLQAADSVHSNEAIETARSIADEGTRVFDEIHDMLDRLGTKSSDGNATPSLQQRFRWCFKKNRVTYLMAQLESLKLSLAVMLQVIQLGQLMASTSRRDPPEEVAVKTEAIKQERLEAQNAVIVRYWQMSKMDRVFEASRREEEDDRRASIDNEAAKDDELKLVSTNESVSTYDPPPPEYAPSSALIKLPVFSLGELDQTLHKIKGSPKEMIQVSDQAIDPLLERWTNWREVRERRHQRDSGGRYAPSVQHLNEEDEEMPYHERFRERDDISRGYYLEGTTTDWRKPNSSAARHEAYRRRKRYENYQPSVSAASSDVEDSPGSASSKRRVARHHVIDSSSESSASEADVAKPKPRRRSSGAGHVQERRISIPEGAPITHAHTTVQPPTWATSNSANNTNRPLSATPGQSTASGLLSPAYHSPGHRPWASPDQNMGHHSLSTPIPALHTANNAPNPYSNYSTYGNAVYPQYPVQSQLHPPSPYLPPSSPQSRYLQQPTSRMGLPPRPVSQDGKQARSPSRLSSHSATPRSHGRGDGDKRHAKEKSTKQNLKESATKGLLGAGAIAGFLEALEGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVR8</accession>
    <name>A0A0D1YVR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239592.1">
        <property type="nucleotide sequence ID" value="XM_016378022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVR8"/>
    <dbReference type="GeneID" id="27330754"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03671"/>
    <dbReference type="HOGENOM" id="CLU_141137_1_0_1"/>
    <dbReference type="OrthoDB" id="5201563at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="132" mass="15357" checksum="03459E7FF96B6C4A" modified="2015-04-29" version="1">MANTETVLEPTTLRETLRVYNVHESGQQEAEAEARAKNESSDQHPMQESRQQDTRPADREWPSDWRRMPPYRETSRVHRVSDRAAGQDAVEGVVVMTMFSGVWLLGNINRLWRATAGRWNDQIMRYQIGGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YW10</accession>
    <name>A0A0D1YW10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239672.1">
        <property type="nucleotide sequence ID" value="XM_016374396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YW10"/>
    <dbReference type="STRING" id="91928.A0A0D1YW10"/>
    <dbReference type="GeneID" id="27327111"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00028"/>
    <dbReference type="HOGENOM" id="CLU_007426_4_0_1"/>
    <dbReference type="OrthoDB" id="4106942at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="325"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="724" mass="81269" checksum="E8228D6BCE004C90" modified="2015-04-29" version="1">MAAGCKAFAASYRAPLVVRESKSVLEADSILFLSQRPVRLKCDRSQPCGNCVTRNVPCVYPSRPRDQSSSVREGGRSNLDARLLRLEQLVGNIAAQRQALETRSTKDESNTDGSSTSPAVQEPLKVEPALMPGRMMGNNSQTVYVSAVHWATICDEIVKVRESIEHDPSTVHLGPSKPGRGDGPLLLQDTGLPCEVEDILSDIPPRDICDRLVSRCFASAEHWIGNCVPTYYTRFWLDPSETPLTWIGMLFGILSAGTFLYARSEDELPPGLGHAVAAMQAFHRRSTDCLIMSDYSTTPGNFTMEALLFNIQGEYVLRPKVQVGVWILSSIATRLAMRMGYHRDPERYPQISPFHGEMRRRVWATISQLDTLTSYQLGLPSIIQESQCDTKLPGNYVDEDLDPDAASLPRPRSERELTPVLYTIAKGRLLSVFRSFFNRVSTVGLTTYQDVMALDQSLNAAHDLVPPRLRLAKLEDSITVSSNILIRRYNLELVYQRARCILHRRHMTESYQHCEYEYSRSSCVDAAMNLLRHQSQIYKEVQVGGRLYKEKWFLSSLENNDFLLAAMIVCLELISHRQHSPADVQMVSGSAGTMNYTRDEMAGALQKSRNFWEEFGTSSAEAQQASTVLAVMLDKVSSSSDMQRVHVPAAPPELTSAGTDLNEIGQMLNSPSFVDWVRTLSDHVRVRSTSLNDEPELTIFYECIQDLWDAHMQNPGPIMEFQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YY80</accession>
    <name>A0A0D1YY80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240462.1">
        <property type="nucleotide sequence ID" value="XM_016375186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YY80"/>
    <dbReference type="GeneID" id="27327904"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00821"/>
    <dbReference type="HOGENOM" id="CLU_663987_0_0_1"/>
    <dbReference type="OrthoDB" id="10676506at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="414" mass="45310" checksum="D035F3AD1EEDAF8F" modified="2015-04-29" version="1">MDDQFDQTSRPAYLQVPQIVIAGAPPPSPAVNPESTLNVAEPATIINSAPDHLQVNGSDMIPRHHHNDVEDALMEELLMENLVEDLGFCHDLGLPCGQNFCLVCGQLQGDVAEPNGTSQPVPPPLDFTYIPEVDNFLSHSPAHQLEPVFPQTSHVPAPSAQNAPLQDHTGSAPVPGQTSSLDVYLVRERDVAIGYWKPHNPPPGPERLMPTEFSDDKPDKPGIDAVRIGQVGNPAEDVYIITEHGKSLERKWRTKLTEQDGNSTDQTDKSCNESTKDSTELQTGNAYASTTESGVMPTGNTYASTSERTMHDNDRTGTLSRVREYQARQRRAGTTIDRTRGSTKHDNDKPGTLSRDQTESGVMQSGNNIESTSESSKLQTGNEYENESETIDNDHDNDKPNAKPEMSAQNRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z086</accession>
    <name>A0A0D1Z086_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_01545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241182.1">
        <property type="nucleotide sequence ID" value="XM_016375906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z086"/>
    <dbReference type="GeneID" id="27328628"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01545"/>
    <dbReference type="HOGENOM" id="CLU_529998_0_0_1"/>
    <dbReference type="OrthoDB" id="4111294at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW20966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="536" mass="61231" checksum="17E2E651FEFB2B5A" modified="2015-04-29" version="1">MAALMANNHGARRSLLTLPPEVIKEILRNLLLVERNRVYQTTWGGMDWPYPDMARDSNEFREWWVRVNDMANPTTARVDRTTELRWARGLAKYAVRLDLAILRVCKTLHEEGVKILLQENKFVAVFGMGQVARVDGMKWPNFWSPSWRWDAENGRFLCSWYGQETVVNVRPVLSLSRQGAKQAERNSFNLMPAADLPCLASALAAEYWDLRKSPADDAEFKLDLTIRANARPSDFGGNNQGGDDIIDYLTPRLFMWVGESVRHVSISVSDPDTVGDDVQICVDLAESIIGIVQAWNRATREKQVELFIQYVSEHLETINSAVKDRNLDKADRAFCRLCEDLQALRFHPAIKPTSERTNFESISLTDLLNGYWTIFALACHSLCSLIPVMNAYPRRFRSRMSFVRWAIMRAEIPISHLRRDREWHLRAALQSTRLLIDAGCTRWVVYNCIHTAAKIIDVCLMNDPTSGRVQRIRDLKRHIPSYNILSLEPASYHYPHPRSLTSRDLAGIEQLATRWTQEVDAVCGDGLVGLSQFQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z1T4</accession>
    <name>A0A0D1Z1T4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241832.1">
        <property type="nucleotide sequence ID" value="XM_016376556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z1T4"/>
    <dbReference type="STRING" id="91928.A0A0D1Z1T4"/>
    <dbReference type="GeneID" id="27329279"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02196"/>
    <dbReference type="HOGENOM" id="CLU_030515_1_1_1"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012316926" description="Cupin type-1 domain-containing protein" evidence="5">
        <location>
            <begin position="16"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="111"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="284"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="445" mass="50280" checksum="A49652D772C418A8" modified="2015-04-29" version="1">MRFSAWSLLASTALAAPTIDWASHLQQQQPLADQESSNGPYNPDHKDQFDHKVDSWAEKLQPLPWRNGDGATMMGPRNKDRERQNPDMLRPPSTDHGSLPNMRWSFADSHIRIEEGGWTRQTTVRELGSSVEIAGVNMRLDHGVIRELHWHKQAEWAYVLEGSVRVTALDTEGGQFIDDLQKGDLWYFPSGHPHSLQGLSPNGTEFLLVFDDGNFDEESTFLLTDWLIHTPKSVLAENFRLSPEVFETIPKSEKYIFQGSLPGPIEDEEPRGANVKKSKLQFTHKMLDQEPLNTTGGLVRITDSTNFPISKTIAAAHLDIAPGAMREMHWHPNADEWSFFIKGRARVTIFAADGTARTFNYVAGDVGVIPRNMGHFIENLSDDEPVEVLEIFKADKFQDFSLFQWMGETPRRMVADHIFADDPEGAKKFLKAVDNPVEDPIRSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAM8</accession>
    <name>A0A0D1ZAM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230273.1">
        <property type="nucleotide sequence ID" value="XM_016386141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAM8"/>
    <dbReference type="GeneID" id="27338916"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11833"/>
    <dbReference type="HOGENOM" id="CLU_1722394_0_0_1"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16952" checksum="B02C3ED4D956DC04" modified="2015-04-29" version="1">MKQVHGESRFRDFENSILTDRRARSKGEGGKIPFATTTPDTELSVWPFARVNDVFLQLQTYEASLHQHWSTTESAELLLNSSVFPFLARILDVKVCMIVAEGDNITAWDLDIEAFNRIASPLKNIQILPGTSHMSLIGASYRVPIACGEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZBK8</accession>
    <name>A0A0D1ZBK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_11359</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230613.1">
        <property type="nucleotide sequence ID" value="XM_016385669.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1ZBK8"/>
    <dbReference type="GeneID" id="27338442"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11359"/>
    <dbReference type="HOGENOM" id="CLU_001471_0_0_1"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="371"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1421"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="625"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="700"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="930"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1182"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1370"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="946"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1235"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1370"/>
            <end position="1386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW10397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1669" mass="182900" checksum="064429D5F3FF0AF6" modified="2015-04-29" version="1">MVSESTVSTRTSLISLDPAIASHITGTTRTTTVPETSQHGSSPRKTAKIADSDVSRRHIRNNSAPNVSGKKKVGSLKRVKNSTEVLRQRSARSSKKTKPLDTIPDTRSGRNFTVGNVGTGGILYLKPSAKQAHPRSAISPPRLPTTAPPALGHETHTLTDQKPVSNPSVTSHTRSASPRRVRSSDRKVAIPNHVRSQSFSTVEERRRSPSASKSKTVRIVIHRPENGRPSTAGQSIEEEEEDEGLPTLEVPIPHYRIGTFRFSTQGTPMLRGSSFTIGSATPSDMTPTPGLMQADQYFGAPPASSLKAFAKLDAAIPGQPAGRQRSKSQLTTSSNSTSATTSTSATSIPPEVFDDLTQVYDDPSVVRYCQNVREITAATPARIIAQISSDSFMDYELVSDFFLTFRSYMSTSTVLDLLMARLRWAIARMEDDGRIIRVRTFAALRHWILNYFMDDFYPHPRLRERFCHEVNKLYADVKASPVHGFSDLKLLRDLKRCWNGRCSLCWDPADFDLDGDQENDIQPGGDDDSESARTPQIGPPHVVHPRCDTPQTEVLRGPAHSWFEAEAVSVHQHHDQGFDPVTDSLMSDGSFQATSCFPHKNLLRLGADPDSTSRGPHPVSVQLRRKNAPSNLQVNTQPNSVSKVLGHRRGPSSIDSNREHTPRKTEPETPAVGFEDGDMIRGLLYSPSGPFVQILPSASTQSLSNTQSGDSQGPQRKEHGRHGITQPMGRNIFGSLRKVLGNRHGHADVTLMSVSQSTTDVPIRTHKAPMPLNVSKSYDELRGKAVPTKVKKAEVRIDLLCAAVCQNYETTFPTKRQVHYSALLGKRTSFEAMDMDDSQDKRLRMTSHATAQSGSILIVDGTGLDLPVMAGALQADSRGSLHEDPALIPLPPEVPVGDDGLMSDDSFDAIATQRSSNLFGNQLGLGAGSNDTLEQLTSSPLLPEPVQREHEFEDLSLDRRPLSPTTASSGTVRGGSGSLDIPRPMTEDTEFQENASPVNDDGGLSHEEAKSHPDNKLPAQTLRRRPGGNLRRVENVQQLDQAIHHSSLYTASIASVSSHESLLLRKTVTRRASEGGPRPGKPISMINTHSSQHLRPSFEAAVAGFSAIPDDDDGGLEATLMKLEGTYEKKSPPIDRHPHDMAGHRRSLPDLRMTSQLELEGPLQPSITAERRPEERVVHETVQELGPEDSQEDLISEKPEVLEIKPSSSRRSSIFGLPTESVADSEDSYGSLPLLRRETAHDSATEAVPAQSKHRPPPIAPGYWAQDPPQLFHLPKGPPPSATKSRHSFPRPETAGNDSNRSFLLDEDENLSDLSSEISVDIINYSEMIGRSMSPMLAAPGTAISGLEIPAHPLTYASVVNLNVPEPTTRVSDPLPQTGTVPSQAPASLARPGLRAPGSSSQIITRLPAGPAHLPFVLACDSQVLAQQMTLVEKSALCEVEWSDLVEMHWNNKAADVLDWVECLADGSIRGIDLVITRFNLVVKWAVSEIVLTHDIYERARVITKFIHVAAHARRLHNYATMLQLTIALTSTDCTRLTKTWDMVSSPDKSLLKHMEALVQPIRNFHDLRLEMESADLSDGCIPFIGLYVHDLTYNAQKPTHIPGGRGQETLINFERYRTTATIVKGLLRLIDASSRYTFAPVQGIIERCLWLAALGDDRIRRASKALEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZBP5</accession>
    <name>A0A0D1ZBP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle tethering protein Uso1/P115-like head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230638.1">
        <property type="nucleotide sequence ID" value="XM_016385694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZBP5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZBP5"/>
    <dbReference type="GeneID" id="27338469"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11386"/>
    <dbReference type="HOGENOM" id="CLU_006318_4_0_1"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="5">
        <location>
            <begin position="341"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="6">
        <location>
            <begin position="832"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="852"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="934"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="944"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="968" mass="108362" checksum="4F3C541086549397" modified="2015-04-29" version="1">MMRILEAQAPARQTATDTIQTLSNRLSSATLLEDRRAAILGLRSFAKLYPASVASGALRDLIAGLRRDGDDSDTIKVVLETLLMLFEPDEKSPEASEEITLWLADEFTQHQDNVTALLDLLESGEFYLRLYVLQILSHISTARPQRTQEAIFAAPLGVSRITNVLDDRREAVRNEALVLLVALTPTSAELQKVVAFENAFDRIFALIEGDGGLSHGSTTVQDCLSLLANLLNLNTSNQSYFREIGGILQIKKQFLAALEQEDSAEAISAWMKPQRDMNVWGLLGVVQLFLASGSQGTALNQQSFWQAGVLPIVLRFAFHPDFSSGIRAKALQACGDIIRGNSGLQERFGDLPVQIKQLNSTSNGHVSQAASEKPSKDPTPVYQDHNVIESLLELALEPAPLALFDVRLAATSCLKAFVENHGGIKAHVLRRAIEGHKSGDDTVPNMLTVLLEPPGTRSTSDPYQQWFAAVLFLHLLYDNAETKELALTVTEGDADNGEEVVTFIQSITSNVVAGVQHVEDERALLGYLMLLSVWLFEDPEAVNDLLGEASNVHGLAAAVKIANSSMPLVAGLCAFLLGIIYEFSTKDSPVPRTRLHALLMSSLGRETYVNRLTKLRENVFIRDFEVLPQSGSGSLPDIFFDKTFIDFLKDNFSRFLRAIDRDPNFEVSIVSNGVQKGVSRDLVDSLRAEVQEQKQALETANTELLQLKRRLEQEELDHRRTRESLSVEVSRIRQINQSLQDNHEDELSKLQQEAAKERSLLVKTHEDEIHRRRTEHVSMVETTRKQHQAEVQKFEQRLKLLEQEAARDRSALIEQHRREINDSDSKAQQALQREAAEIRDLKASIAELEKRLKKSQDEHAQDLQTAHDEYSSKKKDLEERLKRAESRLEDAEQRARLLVDEVDKEKAARKDVQTELDDLLVVFGDLEAKRLTDKQKLKELGQEVSEDEDEEGNEAGSEVTEDEEEDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZF66</accession>
    <name>A0A0D1ZF66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231843.1">
        <property type="nucleotide sequence ID" value="XM_016385241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZF66"/>
    <dbReference type="GeneID" id="27338012"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10929"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="494" mass="54132" checksum="FC66A1AFBA53B65F" modified="2015-04-29" version="1">MESEISIDEERQASASGEHEASQEKRDATNGNSLELVASFESPFDFPTWRKWLMTLLMGGMAAAITFGSSVWSSTLPVTTKQFDVSESVAVLGVSLYVLGFALGPILWGPLSELKGRRLPMFTGFFIWTLLQIPVGVVNNLPTILVCRLLAGCFGAGPMVLISAVYSDFWEPAERGTAAAVYSAAVYIGPTLGPIFGSLLTESKLGWHWTAWLTLIMGGSVGLLAFFFVPETYGPILQQRANRKLHLANNPNASSEDDFEQHAGFEIFVRKYMVRPVKMLCFEPMLMVMTLYISIVYGILYLTFYAFPYNFAEGRGWDPRVASLPFLSILVSVLMGSVGVAIYSREYYRPRLQARGSVLPEDRLPPIMLGSILLPAGLFWFGWCSSPNISPVPQIIAGLFIGSGIMLIFTNGIAYIVDIYLQSAASALAANTCCRSLVAAGFPLAAPRMYRTLGIGLATSVLGILCVLLIPAPLLFYKYGSKLRQMSRYAPTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZM07</accession>
    <name>A0A0D1ZM07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234088.1">
        <property type="nucleotide sequence ID" value="XM_016380986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZM07"/>
    <dbReference type="STRING" id="91928.A0A0D1ZM07"/>
    <dbReference type="GeneID" id="27333736"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06653"/>
    <dbReference type="HOGENOM" id="CLU_110781_0_0_1"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="132" mass="13753" checksum="F0653D8C23A0ED18" modified="2015-04-29" version="1">MAPSSHELSSLLDPLVPESLTHNTRTLSNIRSISGLLLGIAAGILGLESLQGFGFYLAANMILSALFYFLLAGATPQKYFAGNSGTRGLNENGKGRNHGTGAWSEIWLGGGLFTDALSGFVLGWAGVGGVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPC3</accession>
    <name>A0A0D1ZPC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07441</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234873.1">
        <property type="nucleotide sequence ID" value="XM_016381771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPC3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZPC3"/>
    <dbReference type="GeneID" id="27334524"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07441"/>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_1"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000006">
        <property type="entry name" value="Cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="313" mass="33612" checksum="8C2D406B764C7021" modified="2015-04-29" version="1">MSIPQNTTILDTIGNTPLVQLHHIKPDNGARIFLKIESRNPTGSMKDRMALAMIEGAEADGRLKPGGAVVEYTGGSTGVSLSLICSVKKHPLHLVSSDAFSKEKLDHMRLLGATLTLIPSDNGKQTEKLTRDMIREAHKIADQTGAYITAQMENKDQLRAYEKLAEEIWTQTDGRLDGFVQSVGTAAAIRGISKTLRGYDGRVRIVAAEPAESAVLSGGPSGSHKIDGIGAGYVVPLWDDSIADDIERVSTADAKAMAFRLAREEGIFCGTSTGANVVAALRLAQRLGKDATVVTLMCDTGMKYLKTFSEELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZR90</accession>
    <name>A0A0D1ZR90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Choline transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235543.1">
        <property type="nucleotide sequence ID" value="XM_016379716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZR90"/>
    <dbReference type="GeneID" id="27332456"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05373"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF27">
        <property type="entry name" value="CHOLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="53402" checksum="39314E744E9520DD" modified="2015-04-29" version="1">MPELKEKKSTDGPEEALATGGQEIAITLDGEIVNASGHIDQLNRQYGLLSICGLALTVDNAWVALGTSLAVSIYNGGAPGVIWELWVAAFYYSFINASIAEFASSVPSSGGVYHWATITAGPKWGRPVGFFAGSLNYFGWLFDLASIAYIMSELCVQMYFLYHPDYVIQPWNLFVGLLCIIVLCLAVTIFFNGALAYLQHFGLFIVTVGGIITIIVLASMPSQHASTSFVWTDFENNTGWSGGVAFLTGVLNGAFTIGTPDAVTHMAEELPNPKRDLPKAIFAQIGLGFLYAWCFAIALFYGVNDLTAVQNSNGSFPLAQAYSQATGSRAATFGLLFIIFLSLVPCLIGTFLTVGRTWWALARDNATPFSGFFSHVNERLSCPVEATLLTGVLTIGLCAITLGSKTAFNDLAGSFVVLSSVSYAVTILPNIITRRKYMPVGPFHLGMAGYIINGLAVLFIILFDIFFCFPVKSPPPRYAKPPCPPPPPKNTPYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZRF1</accession>
    <name>A0A0D1ZRF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_05418</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235588.1">
        <property type="nucleotide sequence ID" value="XM_016379761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZRF1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZRF1"/>
    <dbReference type="GeneID" id="27332501"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05418"/>
    <dbReference type="HOGENOM" id="CLU_070647_2_0_1"/>
    <dbReference type="OrthoDB" id="5333578at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF1">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237853" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="10">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW15372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="240" mass="24346" checksum="0F728B3C1542D3F2" modified="2015-04-29" version="1">MLSLYQSLLLLSCLPALTLAHFELNFPPSRGTDDENQATFPCGGYSQTQNRTRVSLTEVPVSVKLGHTENLFQVTLAIGDDVGSSFNYDLLPTIQEFGPGDFCLSSIPVPADLNITDGTNATIQVITNSHDGSGLYNCADITFTATDPETPSSCTNGTGISATPLSANAYTNANESSGHEDGHGHGSSASGTASGSSSSSSSSASATAAPSGSSDNNGASMMTVGWGVLGAAVLAGVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTI1</accession>
    <name>A0A0D1ZTI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236298.1">
        <property type="nucleotide sequence ID" value="XM_016380471.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1ZTI1"/>
    <dbReference type="GeneID" id="27333216"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06133"/>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="OrthoDB" id="4158009at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="4">
        <location>
            <begin position="25"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="283"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="854"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="896"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="937"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="979"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1105"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1147"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1190"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1242"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1289"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1331"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1373"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1505" mass="167416" checksum="EF84E209B751F532" modified="2015-04-29" version="1">MRLLKLGSHGDLSLTKNLIEDVPSYAVLSHTWGTDDDEVTFDDIKNGSGTSKVGGYAKIRFCGEQARRDGLQYFWVDTCCIDKENHAELAQAIASMFRWYQNAARCYVYLTDVSARKCHNSQAERPWESAFGKSRWFTRGWTLQELLAPKSVEFYSHEGERLGDRNTLEQEIHETTEIPLTALRGTPLSHFSVDERLRWAAKRHTKLKEDKAYCLLGIFNVFLPLIYGEEDNAFIRLREEIDKRLRSKLDLDKLPHAKGAMFNAYGGDHRTCHPATRVDLLCQIQNWAQQPRSKTIFWLNGMAGTGKSTISWTFAEWLTNQGHFGLVNLGGSFFFKRGDGDRGSASRFFSTITRQLVLKIQGMDTLIANVITSDPLVFDKALGEQFDKLIYQPLCNVSPGGCPILVLVVDALDECEKEGDIKIILDLCSRLSQISTIRLKLFLTSRPDLPVRLGFKSMSVETYQDLILQDAVPRTTIRHDISVFLKDAFSEIRANYNADPPLGGPLGHGWPGENVLEGLVDMAVPLFIVAATVCRFVGDPNWDPQEQLQTILKLRATGHLEQMEQTYLPVLTQLSATLSNSRDKEKLFQEFRTIVGSLVTLAEPLSATSLAALLSMPSANIARRLRPLHSVLQVPADAEIPIRTLHLSFREFLLSDKLQHEPFGVDGPATHRMLLTRCLQLLSGSNGLHENLCDLSYPGQLRREIDPSTIEQHLPPVVQYACRYWVHHVQHGMVQIHNEDEVHVFLQKHFLHWLEALSLMNRISEVIGQLGILQSLMRRQVNASSRIAAFLEDAQRVVLANRYIADLAPLQIYSSAMIFAPQTSIVRNICSQTPIWIQRYPITPVTWSAELQKLEGHSDSVNAVTFSPDDSLLASAADDGTVKLWNSSTGQEVQTLNGHTKSVTEMAFSPDGSLLASTSSDQTVSLWNSSTGQEVQMLRHSEWRNVVAFSPDGSLLTSALSHGTIKLWNLSTGQIVQTPKRHSDRMRKIIFSPNGSLLAAALSAQTIMLWDSSTGQEVLMLNGLTTGSVTAMAFSPDSSLLACASSEGTIKLWNLSTGQIVQTLRNVGWVIAITLSSNGSLLASAHQDTTIELWNLSTGRKMQILEGHTKRVNALTFSHNGSLLASGSTDQTVRLWNLTKGQEVPKLQEHRDPVQTVAFSHDGSLLASISNNESIIRLWSPNTGQEVQRLQGHTGLLHSVAFSHDDLLLASTSSDGTVRLWNLTTGQEVQKLEGHTFCDTRAVAFSLNDSLLASVLGDRTVRLWTPTTGQEIQKLKGNPISRRARVYEFIGHDNFDTVVAFSHNGSLLASVFGDSRVWLWDLKKGLEAYKLNKHTGFVKAVAFSHDDSLLASASGDRTVKLWNLRTGQVVQTLEGHTGSVKAVAFSHDGSFLASASDDQTARLWNLSTGREVQKFENVPAIETLRFTIDDKTLLTNRGAISIDGESITHGSSTASMVKNDWVQRGHQNLLWLPQEYRSNCSAFYDNTFAIGLHSGQVIFLHLDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZXU7</accession>
    <name>A0A0D1ZXU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_04651</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237673.1">
        <property type="nucleotide sequence ID" value="XM_016378996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZXU7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZXU7"/>
    <dbReference type="GeneID" id="27331734"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04651"/>
    <dbReference type="HOGENOM" id="CLU_017633_7_0_1"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF46">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="13">
        <location>
            <begin position="14"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="14">
        <location>
            <begin position="121"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW17457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="187" mass="21578" checksum="33EEE1EC64F3F379" modified="2015-04-29" version="1">MSTTAAAHQKHSHTHYDVLRLSRGADWSRVSHEDVKSAYRRALLIHHPDKAAQVSFKKQQQQQEQEQQKPPSRNDSPAYSIDDIVVAYEVLADPRKRRMYDETLDKRDGSTLNRKDNTHIGVEAFDLEDLQYDERKNTWSKSCRCGEERGYVLTETDLDEESQDGEIYVGCRGCSLYIKVLFALEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0Z3</accession>
    <name>A0A0D2A0Z3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238858.1">
        <property type="nucleotide sequence ID" value="XM_016377288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0Z3"/>
    <dbReference type="GeneID" id="27330014"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02931"/>
    <dbReference type="HOGENOM" id="CLU_044876_1_1_1"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="360" mass="38917" checksum="87C9661DA696E324" modified="2015-04-29" version="1">MDSNNHISKVALVGATGTLGSHVLSGLLDQPFPQFQITLITRPGSITSSKHPDLTSNPRITIKVGSYEDHAFLVSALTGQDALVVTLGFNVCHTLQPLIFRVACEVKVPYILPCEFGSDTTNPRLVSAIPGQISKVNARRLIEDLGTAPDGTRTSSWIGICTNAWLDWNLPGGWMEIDIKNRTATLLDGQGKDKDVKAYFSTIRMSALTAAKVLSLPLKADDKSSGSSPSSFSTTTTTTTQRTLPSFANKMVYAACFRLSQADIICAVQRATRTTDTDWQISHVGLTRYLDSAAEKVKAGNRLGIMDLLHGNLFVKGVADAFYPDGAEEEAELNNTLLGLDECEDLGDVMAKIVKQVLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0Z6</accession>
    <name>A0A0D2A0Z6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_02936</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238863.1">
        <property type="nucleotide sequence ID" value="XM_016377293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0Z6"/>
    <dbReference type="STRING" id="91928.A0A0D2A0Z6"/>
    <dbReference type="GeneID" id="27330019"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02936"/>
    <dbReference type="HOGENOM" id="CLU_004869_0_0_1"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="30"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="636"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="221"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW18647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="940" mass="106522" checksum="2E0EDBEE020ACEE4" modified="2015-04-29" version="1">MDTYTFATSRQIDFPVCLRINTLEGKQSTIPQTVLLKHPEIRHVGSVQNPLSELFVTVQLWAESKPLGVSVQTPHTFFKNTRTWNKWLELPVPVRDCPASSQVAITVWDLSACPLDGSVDHSVPFAGTTIPLFDDDGALRRGRQKCRMYRKKIADGHLPSTTPHIPRPKRRRRNEARPQSSPEEEELERLEQLFKKHEMNEIPQNDWLDQLVFQNVGKKAREVDEAARKRASMRKAAKRRSRKDDSSKLAAGGHTDQHDSDLSDSESGTDDDEHFTLYIDFPRWDFPVVFEDHEYNPPKLMKEFQTNMSASMTGTKPPPEVRYGPGIAAGNSVVDDEDHPVVQIFDPEQFQRENPCESKHRRLVRSDRNALYDVDQKPNAKLRDEINEILSYGPTQELTPQEKDVIWTFRRHLSRDKRALTKVVKATDWNSPSEARQMAELIPKWAKIDVDSALELLGPTYDSAVVRAYAVDRLRQAGDAELLLYLLQLVQALKFEQYDSQAETLPSSSLAKFLIDRAANNFKLGNYLHWYLMVECDDQGPDTNAANRKLFARVEYHFMVELEKRAPEQRKTLLRQAEMIAILSRISKEIRFTRNNRIQKIEMLKKYLADPKNELIKIDPPIPLPLDPEIEVSGVFPDEANVFKSSLSPLLLNFKIAGSVEAGNFSSQARSQSQAKYPMMFKTGDDLRQDQLVIQIIELMNNLLLKENLDLKLTPYRILATSPTAGAVQFIPSTAISAVSAKYKGSVLAYLRANNPDATGPLGVRKEAMDTYIRSCAGYCVITYILGVGDRHLDNLLLQPSGHFFHIDFGFILGRDPKPFAPLIKLCKEMVEGLGGTASPQYAQFKQYCFTAYTTLRKSSSLVLNLFSLMVQSSVQDIRLVEEQTGGIGGAVGKVRERFHLDVSEEEAVRLLDQVLADSVNAVFGVVIDRLHEFVQGWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A2L7</accession>
    <name>A0A0D2A2L7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239408.1">
        <property type="nucleotide sequence ID" value="XM_016377838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A2L7"/>
    <dbReference type="STRING" id="91928.A0A0D2A2L7"/>
    <dbReference type="GeneID" id="27330569"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03486"/>
    <dbReference type="HOGENOM" id="CLU_030671_1_0_1"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35931" checksum="C421AE89BE5F3C4C" modified="2015-04-29" version="1">MASLAKQVPSFEQLPLRKEDPPYSAWGLWEKPEFGALNYLSDTNTLRVAKEEIQTGVRIGLNLPLDFIDPPLLGRRGFERYIVNKAPRVINDDVITFNTQGSSQWDSFRHFAYQKEGKFYNNVTQNDIHTEQRSTINGIDAWALQGIAGRGVLIDYHSWAQRNGIEYDRLSGHAITLDSVKAIIKESNIALRAGDIFILRTGFVEVYSKLDTASRTEYSSSHAFPGLGQSKKVAKWLWEQQFAAVAGDNPAFECIPPADPKFGMLHPILLSGWGTTIGELFDLDALAKECQKQGRWTFFLTSSPLNYTGVVASPPNIMAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3U0</accession>
    <name>A0A0D2A3U0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_00074</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit apl3 and beta-type subunit apl1), a medium chain (mu-type subunit apm4) and a small adaptin (sigma-type subunit aps2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239718.1">
        <property type="nucleotide sequence ID" value="XM_016374442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3U0"/>
    <dbReference type="STRING" id="91928.A0A0D2A3U0"/>
    <dbReference type="GeneID" id="27327157"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00074"/>
    <dbReference type="HOGENOM" id="CLU_061221_3_2_1"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW19502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="167" mass="19192" checksum="BD60C7C1E9362C2F" modified="2015-04-29" version="1">MVLSFILVQNRQGKTRLAKWYAPYTDEEKVKLKGEVHRLIAPRDQKYQSNFVEFRSAPSSGGSSSSSSSQPLVRQNLSSTKIVYRRYAGLFFCVCVDANDNELAYLEAIHFFVEVLDQFFGNVCELDLVFNFYKVYAILDEVFLAGEIEETSKQVVLTRLEHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4K9</accession>
    <name>A0A0D2A4K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_00346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239988.1">
        <property type="nucleotide sequence ID" value="XM_016374712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4K9"/>
    <dbReference type="STRING" id="91928.A0A0D2A4K9"/>
    <dbReference type="GeneID" id="27327429"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00346"/>
    <dbReference type="HOGENOM" id="CLU_057366_0_0_1"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW19772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="299" mass="32776" checksum="D78D17AA69B2500D" modified="2015-04-29" version="1">MPICITCSTPVKNLYTVYSKADDRTLGKGVRLTQCPNCKRFADKYVEHDFVVLFIDLVLIKPQVYRHLLFNRLGRSDNRLDPSILRLGILLVLFDVYITWARIEKSSTVNGGNNPNSALTGMPILTQYLFFLTMNVLATAAQHAIIRFLARFLVTEREQHGDHPNSKNSPRVSSADGNVHPIVAPGQASPSAISTALLVSSCTKLFPIFLVIWPTEVNGGGPSGFAFRATNYVAWAVLVNNIEALLILLNCGYVAATGMAVSGMLARWAVEYWALRFVGLGSDPKPLGGLATALNVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5L2</accession>
    <name>A0A0D2A5L2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00612</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240253.1">
        <property type="nucleotide sequence ID" value="XM_016374977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5L2"/>
    <dbReference type="STRING" id="91928.A0A0D2A5L2"/>
    <dbReference type="GeneID" id="27327695"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00612"/>
    <dbReference type="HOGENOM" id="CLU_085878_2_0_1"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="79"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="167" mass="18627" checksum="5D314C0BDC7C3FAC" modified="2015-04-29" version="1">MFFLRYLEREISIHPSFFGSSVHDRLRDQLYADLEGSCNGEYYIVCIMDIHNISPGKVRPGSGEAHFTILYRAILWKPFKGETIDCAVTSVKPQGVFCEAGPLTVFVSKMHLPPDMRHNPDATPPQYSNNAGDVIEKGSAVRVQLIGLRSDVGNMYAVGKMSAQWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A816</accession>
    <name>A0A0D2A816_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241138.1">
        <property type="nucleotide sequence ID" value="XM_016375862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A816"/>
    <dbReference type="GeneID" id="27328584"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01501"/>
    <dbReference type="HOGENOM" id="CLU_1482015_0_0_1"/>
    <dbReference type="OrthoDB" id="4153744at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="192" mass="23465" checksum="56BF22AED70CB45F" modified="2015-04-29" version="1">MSDRYMDRHYDYQDDKHMDRHELDDERHQGSSRYIQEEEDPRSSERSRKGKEKEREKHDEPARKRRDKSHLYDDMHKAYNTKALIQKYEGSDWYPDRDADIMDHAIAQTERKSQWTDNPSQATRDRRERARKKVSRENHENFNQVLPGERIEPRDWEYRQASSKHYSSQDPDMPPQVTTNSIERIKKKYPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8J0</accession>
    <name>A0A0D2A8J0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01656</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241293.1">
        <property type="nucleotide sequence ID" value="XM_016376017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8J0"/>
    <dbReference type="STRING" id="91928.A0A0D2A8J0"/>
    <dbReference type="GeneID" id="27328739"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01656"/>
    <dbReference type="HOGENOM" id="CLU_015502_2_0_1"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="634" mass="70378" checksum="4FDEA51BE49D520E" modified="2015-04-29" version="1">MNTTATSAAPLSRRRKSRSSLACLPCRSRHLKCDGVRPYCSRCIVAAQQCQYAQSRRGGLDRAALAERRKRLEATGSTQAESGSADILRPLQSSWALPRDREAPLQPPLPLSGVVGADITNDYETDAGSSTSSPRGGIDDDIEGDSLIASYYQNFHKFHPLVLPQKHLIRIHRTPTIKLNLRPLLAVLRLIGHIYSAREWSTSLRDHVEARFAEASHADPIMVQCRTLYSIALFWNTYKDESKKEMDAAVRLALDLQMFRRDFAAKQGSQDAVLTECWRRTWWTLYMIDAFYAGTLGTMNFATIDIVSTVDLPSEEWEYEEGQIPEPKTLQDFDCRDLAPESTSFSSFAYLIGAVRCSALAISTAPKVATSECSQQILQAADAVINGWLLLLPKGRKQVMSKTGELDELMFQAHLLIHVATIGLHRPLSDLKFNPIEWISSCARAPPRETPTPELINVHTVRVLKSIEAQIRLLALPTTEQFHHSPFTTCMVSEGTLALLSGCKFLFKGKELAVARDQIRMTIGCLKVLGEVWPRTAKNVQEIQTIARHVLGLGNPGATEPDNSVRGPSEVPSLSSNDQGQTTNEGPDDEDPSPNNDIDIFPSLGSMEDLCGWFNNNPSEFAQDPSWWTETALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AU11</accession>
    <name>A0A0D2AU11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230449.1">
        <property type="nucleotide sequence ID" value="XM_016385505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AU11"/>
    <dbReference type="STRING" id="91928.A0A0D2AU11"/>
    <dbReference type="GeneID" id="27338277"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11194"/>
    <dbReference type="HOGENOM" id="CLU_036110_1_3_1"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="360" mass="38771" checksum="0BD7322B10564C5E" modified="2015-04-29" version="1">MDPQTEPRFIQHHPSFSKIVGRDARYQLLCESQFPLFHEACIFDPRDNSVFVTSNQLHNDAGHDSADTDNKHVKLTCIRDTVGGEAVVQEISFPGSDHAMLNGGVNFGHGTILLCAQGSKNPSDISGIISLGIPPPGYGAPPRVVVDSFHGIPFNSVNDVVVSPTDGSIWFTDPSYGHGQGIRRAPQLPNQVYRYDPHTKTIRAVADGFVRPNGLCFSPDLRTLYVTDTGAIHGSPDVPIDLSGPSHIYAFDVVHVASDDSDSESSSKEPFLANKRLFAYAPGRFPDGIKCDTAGNVYAGCGDGVEVWNKAGVQIGTMAIPGGVANFCFGRQGVIYACNETRLWKIFLEADTVKGALLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVH6</accession>
    <name>A0A0D2AVH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230949.1">
        <property type="nucleotide sequence ID" value="XM_016384347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVH6"/>
    <dbReference type="GeneID" id="27337115"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10032"/>
    <dbReference type="HOGENOM" id="CLU_015676_1_0_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF26">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="71259" checksum="F451D7707AACC262" modified="2015-04-29" version="1">MAPIALSGFPQPALHSAVDYNDLKVKVVSNAVEVEPTPVVADNFMYDFKYNHELPTSDVLGVEVPLDCDAQKEADNIVSQLSEVMGGRNAAGFADLFWEFGVWRDKLSFTWDYRTFNFRPAILKAATDLFANTTASSFKFLDPAPQVSRPYPDFSQLQFVVSFETELVIASAVINAVLTKDGWRIYTMHSVAEELKQFPEKAPKDGHMIGLQSWEKQRANEIDAANPEVLIIGGGQNGLALAARCQALGLDSLIIERNEEIGDVWKKRYEYLSLHFPHWADDLPYFSYPKHWPTYTPAQKQGKYMEWYASALELNVWCKSTVVEAKQTNRQWAVIINKEGKEQRTLYPKQLVMATSLCGVPTTPVVPGMADFKGTIRHSTAHDSSRGFKKVCVVGTSSSGFDTAYECARLGIDVTLLQRSPTYIMSLTNSVPRMIGSYAPDSHGNRRSHEELDRLFFATPTGPGEELARRGAKVLEDLDRPLLDGLHARGLKTYRGQRGTGNATLGSTRNGGFYFEAGACEQVIKGNIKVEQGFIERFTEDKVILSGSREREFDLVVFATGFSNVIDSVRATLGEEIAAGCGPIWGIDEEGELRTAYRESGVPNLWFMIGYLPMTRYHSKLLALRLKALKEGVGHAPYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYX8</accession>
    <name>A0A0D2AYX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">INO80 complex subunit Ies4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231876.1">
        <property type="nucleotide sequence ID" value="XM_016385274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYX8"/>
    <dbReference type="STRING" id="91928.A0A0D2AYX8"/>
    <dbReference type="GeneID" id="27338045"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10962"/>
    <dbReference type="HOGENOM" id="CLU_058488_1_0_1"/>
    <dbReference type="OrthoDB" id="4093188at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013175">
        <property type="entry name" value="INO80_su_Ies4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061">
        <property type="entry name" value="INO EIGHTY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08193">
        <property type="entry name" value="INO80_Ies4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="28859" checksum="B9891E5181DFCCD3" modified="2015-04-29" version="1">MAISSSSTPGRSPSARPDKGKKQGKVVVLKLSPELLRRFEEPSMKTEEPSVPSSASSPAPAVDDQPTVKAPDSHDNASESNSTPAPNGDTPNGDTSKKRKNPGAGSKRSLGQMASESSGTPKPRGKPGPKKKQRLDDGTIDPGSNRPSLPAMPGGHRLGPKANQGAINAGLRALDRSGKPCRKWTKKPFTLKSFTGIVWEVPSWKGNERLLMLNGEESSDAKETSQQSSSDMKPNESDTAMDSNAGEQPDPMILTTPAASSPAPMPPPPAAVAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZB7</accession>
    <name>A0A0D2AZB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycoside hydrolase family 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_09082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232026.1">
        <property type="nucleotide sequence ID" value="XM_016383403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZB7"/>
    <dbReference type="STRING" id="91928.A0A0D2AZB7"/>
    <dbReference type="GeneID" id="27336165"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09082"/>
    <dbReference type="HOGENOM" id="CLU_009935_2_1_1"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF4">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="6">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="4">
        <location>
            <begin position="290"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="5">
        <location>
            <begin position="410"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="72563" checksum="1497219BB891A31F" modified="2015-04-29" version="1">MTASVTYPRPDFQRTTFTWSSLDGPWDFIFDDADGGLVQRWPQVGLPIDSNGHKKRTITVPFAFQTPASGIGLHEAHEVIWYERTISDIRSENETTRDNRLVIRFGAVDYECSVWADGRYAGGHCGGHVPFDVDVTDAFIGSDPPKTLRLTVRVRDSPYDLTQPRGKQYWGPVSESIFYSPTSGIWQSVWLESLPAMRLAGGSDGTILRSDDIESGVLHARVAVVGRRAGQKCAAEIEASLGGIHVGSTKIDLPSDKNFVLLDLGMKVPNASELQKKPPFNVDGSWSNGVALWQPEHPALYDVTLRLYNDSGMMVDEVQTTAGMRRITWNTGDGTFRLNGKPYFQALVLDQGYWKDTGMTPPSPDALKADIHMSMDMGFNGCRKHQKVEDPMFLYWADRLGYLVWGEMASAYEFSDDYVDRFNGEWIESVKRDINHPCIVTWTPNNESWGYPSLKGSIDQRNHMRSLYYMTKTLDPTRPINDNCGWEHVLTDLTTYHDYADSPELAVSCSKLEGGILDKKSDREMFTKQIHAGSVCIDPGAQHKQGAPVICTEFGGVNIAPAKGAFVNERDWGYTTAADPQDLLNRLEQLVMAVVKGGHSCGFVYTQLYDIEQEVNGLYSYDRQEKVPGAKVKAIIDAAKEHYYSVVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZK4</accession>
    <name>A0A0D2AZK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_09423</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232364.1">
        <property type="nucleotide sequence ID" value="XM_016383741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZK4"/>
    <dbReference type="STRING" id="91928.A0A0D2AZK4"/>
    <dbReference type="GeneID" id="27336506"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09423"/>
    <dbReference type="HOGENOM" id="CLU_027359_3_2_1"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
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        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
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        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
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        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
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    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
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        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
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        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_B5_1"/>
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        <property type="entry name" value="CYTOCHROME_B5_2"/>
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        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="354"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="450"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW12148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="480" mass="54229" checksum="B7F2F241D8DE2D0E" modified="2015-04-29" version="1">MPSSQPAAGDLAVKPEYLSSTPSPMAKPSEPNRNSKYDPKKPHITETPMTTSNWYKHVNWLNVTLIVLIPIYGCVQALWVPLQFKTAVWAVLYYFATGLGITAGYHRLWAHTSYSATLPLRIFLAAVGGGAVEGSIRWWARDHRAHHRYTDTDKDPYSVRKGLLYSHLGWMIMKQNPKRIGRTDISDLNEDPVVIWQHKNYLKVVLFMGLICPMLVAGLGWGDWFGGFIYAGILRIFFVQQATFCVNSLAHWLGDQPFDDRNSPRDHVITALVTLGEGYHNFHHEFPSDYRNAIEWHQYDPTKWSIWLWKQLGLAYDLKQFRANEIEKGRLQQQQKKLDQKRAKLDWGVPLDQLPVLEWDDYVEQAKNGRALVAIAGIVHDVTEFIKDHPGGKAMINSGIGKDATAMFNGGIYMHSNAAHNLLSTMRVGVIRGGCEVEIWKRAQMEAKGEVSRDSSGERIVRAGLQPTKVLQNTPTAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B160</accession>
    <name>A0A0D2B160_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016384246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B160"/>
    <dbReference type="STRING" id="91928.A0A0D2B160"/>
    <dbReference type="GeneID" id="27337014"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09931"/>
    <dbReference type="HOGENOM" id="CLU_019106_1_0_1"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="7">
        <location>
            <begin position="531"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="605" mass="68525" checksum="9E76869D5EC273C0" modified="2015-04-29" version="1">MAKKRKAGRASQQDAPSRTDRYDVEERFDDSEDEFFAGRDKILLDEAPAAKRLRRLEEQEKHLQSSDEEVYEDAQAEVEDDLEDDEDVDFDADARGRKDGDEDEELDENWGTSKADYYNADVIETEADALEEEAEARRLQQKQLQSMTEADFGFDESAWVDETEKTQDKRPAVEKLPELQIPPNATAEERTQILKSRYPEFEPLAHDFVSLQDEYRESKKKIELSDVQGARGIQDKISLTRFRALSSYLGAVAMYLAVLTSSKSGTALPPGELREHPIMSNLVRCRQLWQEAQDLKVVEVPTVREEAVSVKPREVKVPEQPKPNVESKKPEKSKKSKKPTTKSTVTTEDVVPEPVPSTKKTKKSKKPKRDDLQELLASSLQTPRDDESDFGDEVPLTAEEAAEKAKRKRSLRFYTSQIAQKANKRGAASRNAGGDDDVPHKERLRDRQDRLMREAEMRGREVAHGDEQVFDSGDDDTGVGREMKDDANEYYDMLVSSKKAKKADKQARAEAYAEAARQGAQVYEEEQVGADGKRKITYAIEKNKGLAPKRKKDVRNPRVKKRKKFDEKMKKLASIRQVYKGGEGRGGYGGEATGIKTNVVKSIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2M2</accession>
    <name>A0A0D2B2M2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233394.1">
        <property type="nucleotide sequence ID" value="XM_016382691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2M2"/>
    <dbReference type="STRING" id="91928.A0A0D2B2M2"/>
    <dbReference type="GeneID" id="27335448"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08365"/>
    <dbReference type="HOGENOM" id="CLU_760903_0_0_1"/>
    <dbReference type="OrthoDB" id="4540880at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053018">
        <property type="entry name" value="Elsinochrome_Biosynth-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="358" mass="41328" checksum="2BBD43CE0EE4C7C0" modified="2015-04-29" version="1">MTTRGVLNGERMVQVLIAFVLSAAFALVTAYLSLSLQLIHFFEARHTAETFESAVDSKTIKNAVLVTLRYLYSLFRYAFCRNGVRRDGTLSQSERQRLYKFCEDFLLTLSDQQLVTGIAILVAGWINRKTSTVYQFEMVNALAWMSSDVHLLTVGQLRAFFRKNPLAKHWRAAGMFSTFVLLFVANFYRGHVDWYSNFHHPTQCLIDDVNRSASYIRGSAAENMLIWGLLLFYSYARGIIPLYYDTDKWRDRLLSLREGYLRDNRRVSYIRLALLDIFWIVSSEVFNVIIVQTFWFSYGNRSIWCDRILALSYGVLDAEDSAWGLGEIVPLFLLALPVLNSLDFFIWIHKPTSEEAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2X7</accession>
    <name>A0A0D2B2X7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233509.1">
        <property type="nucleotide sequence ID" value="XM_016382806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2X7"/>
    <dbReference type="STRING" id="91928.A0A0D2B2X7"/>
    <dbReference type="GeneID" id="27335564"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08481"/>
    <dbReference type="HOGENOM" id="CLU_069253_1_4_1"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="6"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="217" mass="24624" checksum="2D34C3D420051FEE" modified="2015-04-29" version="1">MPRPRLTLYFDLHSPYSYLAFYLIHTSPVFKQCDVTYVPVLLVAFIKAVGLQPPWGSPTKPSYMTTDITRWARDYDIPWTPGWPANYPFKSTTLKVERFLVACSRECQQQYPNVIAALYHAFWVEKKAVQLSEVYEPIAADVLGQETAQKVIERSSTEEVKNLLKHNTDQCIASGSPGVPWIRAVNPQGQEECYWGFDHLGQAAQHLGLGKLKGPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3X4</accession>
    <name>A0A0D2B3X4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kri1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233601.1">
        <property type="nucleotide sequence ID" value="XM_016382898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3X4"/>
    <dbReference type="STRING" id="91928.A0A0D2B3X4"/>
    <dbReference type="GeneID" id="27335656"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08573"/>
    <dbReference type="HOGENOM" id="CLU_009647_3_0_1"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="459"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="601" mass="69093" checksum="D10A94EBA04E3BFA" modified="2015-04-29" version="1">MARDLLNDSSSDSEDGGAEVHPVDFKVNESFARRFEYNKKREELQRLSEKHGEASRKRKRTDDPASDDDSSDESTSESEDEGDLATAALDSEIMATINAIRSKDPRVYDQSAVFYTAGEDTTPAESRAKKDEPMHLQDYHRQILLNGGPAEEDEPAPLTYTEEQEQLKKSVVGEINAAAAEAASGSEDEDESRGEVDEFLVAKERKKSSREQVTLDVENAERDPETFLSNFMVSRAWAASDSRLHPFESDDEEEERRAEEYEEAYNMRFEDPAKSNEKLRSHARDAAAKYSVRREEANPRQKKREAEKAKKEAEKQQRKEEKARLRKLKIEELEEKLKRIKRAAGLSTKDLQPDDWSHLVDDDWDDAQWEAEMQKRFGDEYYAQKEVGSDEEMAGEKTKIRKPKFDDDIDIKDIVPEFQDDEKAEFSLSDEEQGGRKNKKSKKSKDDTKREARKERRIIEQLVEDQLQLELDNSVPKKAGFRYRETSPKSFGLTARDILLADDKQLNEFAGLKKLAAFRDPEKKRKDAKHLGKKARLRKWRLDTFGKEDGLEASELVPKESAVEEKIEAADGNVDNINEGRRKKKRRRNNKKSKVEVNGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4J4</accession>
    <name>A0A0D2B4J4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Branched-chain amino acid aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233821.1">
        <property type="nucleotide sequence ID" value="XM_016383118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4J4"/>
    <dbReference type="STRING" id="91928.A0A0D2B4J4"/>
    <dbReference type="GeneID" id="27335878"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08795"/>
    <dbReference type="HOGENOM" id="CLU_020844_4_1_1"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000002">
        <property type="entry name" value="D-alanine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36716" checksum="C615E5AD20E139FB" modified="2015-04-29" version="1">MAFMDKVFGAYDRRTATLTKTDNPFAKGAAWVEGVVVPLHEARIPLLDQGFLHSDLTYDVPAVWDGRYFRLDDHLTRFEASLVKMRLTLPLPRAEVRAIMVDMVARSGIRDVFVEIIVTRGLQFVRGTPLESHIHNLYILIMPYIWAMPPEIQRTGGSAIVARTVRRTPPGSMDPTIKNLQWGDLTRALLESHDRGALHPFLTDGDANLTEGPGYNIILIKDGVLYTPDRGVLEGVTRKSVMEIARANGIEVRKQVVPVELAYQADEIFTCTTAGGVMPITSLDERPVKDGQIGPITRIIWEEYWEMHYNPQYSFVVEYDNRSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B601</accession>
    <name>A0A0D2B601_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234554.1">
        <property type="nucleotide sequence ID" value="XM_016381452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B601"/>
    <dbReference type="GeneID" id="27334203"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07120"/>
    <dbReference type="HOGENOM" id="CLU_2121092_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="114" mass="12446" checksum="17C51CE1AF485537" modified="2015-04-29" version="1">MSSPTKDKSRASGSEGTMKSSSQDSTQESSLIRDGSSKSPVMRHLSPPPTALEDISPELSHVIDEWSGQDSPFSPQDSQDFEARVMKNEFDVHSLGYVTSLPEIEDELNADTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9N1</accession>
    <name>A0A0D2B9N1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235889.1">
        <property type="nucleotide sequence ID" value="XM_016380062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9N1"/>
    <dbReference type="STRING" id="91928.A0A0D2B9N1"/>
    <dbReference type="GeneID" id="27332805"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05722"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="290" mass="31346" checksum="1C63E0A075FC8B2A" modified="2015-04-29" version="1">MAAKADIRLDGKVALITGAGRGLGAGLAKMLSERGASVILNYASSAKAALATVAEIEKAGGKAVAIQANVTKVPEVEKMFEEAIKAFGKLDIVINNAGMEHFGKTQDVTEEEFDAVFGLNTRAQFFVSSRALRYLSDGGRIIFMSSIAASLSVANHALYCASKSANEGLARSFAADGGPRRITANAIAPGGIKTDMFAQNAWHYSPGATKDTPIEEIEAGIAKLIPLNRCAVPDDIAKVVMFLCHDDSEWVTGKFFEFDGRRREILGQTVRNQDFDANFFFRPNHSFDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BA37</accession>
    <name>A0A0D2BA37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_05908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236074.1">
        <property type="nucleotide sequence ID" value="XM_016380247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BA37"/>
    <dbReference type="GeneID" id="27332991"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05908"/>
    <dbReference type="HOGENOM" id="CLU_032492_0_0_1"/>
    <dbReference type="OrthoDB" id="4150142at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW15858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="593" mass="67701" checksum="8DE6302D5477C4C0" modified="2015-04-29" version="1">MSCSSGYRRGQGVTISTHPPIFQPLPSRLSPCTVSYPPLHLLGVPQEIRDRIFDIIDEDTGKACAKSLENLPVTGYEALPLICKQLSLETSTTSDWLPRNRIVRHKQVGLFLDWAIYNTPVLPQLQSLTIELPHDSPTTIFTRLAKLFQDDLTGLQELKILGVGHDRYGQKMFWRDERCGKNDTSMSNSTRGRLLIEAQEWKRRMVVINALERLSNLEVLVIDHFNLPVTQAHVLKNKPRLRRLRIGTDERSALHHEMRSSIGNLALPLKESAPALRELNLCANGVLTTFGIIDKVAETLEKLTYTVPDSCHQPAGNINFLHEAGMVLGVLGRKARKLREFRICVHGNVYEIPAHSNFIGNMRPALERMRELEVLEMHMHLESLYLASEFIEGTPGSVERLYLSDQFFCRSAKSFAEILNWQSCVIVKEDIVEETMNIKRELDRRDFIPFSNRLEFIEYEFHSNLSPPQRQELRRLLKINARLLDRARNKHLYFNYARHIPYGVCEETVLSDDVWEDAELLQGSPAATPEEMDGIREDLEQCGLTDNEYFGTENDAYAVFQKEPATKISDRLPASYPCIVAVEAGSEHWLSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAN1</accession>
    <name>A0A0D2BAN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_05694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235861.1">
        <property type="nucleotide sequence ID" value="XM_016380034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAN1"/>
    <dbReference type="STRING" id="91928.A0A0D2BAN1"/>
    <dbReference type="GeneID" id="27332777"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05694"/>
    <dbReference type="HOGENOM" id="CLU_030660_0_0_1"/>
    <dbReference type="OrthoDB" id="5312133at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055:SF1">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW15645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="634" mass="71494" checksum="A4FFB3EA009B968A" modified="2015-04-29" version="1">MAPRRLSRYIVVGVVFLIGFLIFSTTSNTAPSALDEASGYREALRESISNLNVPFRFTFQKSAHKPPQQKNSTHGDSSWYSHWTWLNPFSSSITLDEERVVLPPLPERPPVYTYYDTTVKRDENVKEVDKELLLTWRRAWWAHGFRPVILTEAEAMSHPLYQTLQAEKLPPALEQELRQWMAWAHMGTGMLASWYCLPMGAYDDFLLSHLRRGQYPHLTRFEGLGSGLYAGEQTQINNAIKAVLENPKSTASTASMIEALGSEWFKVEQPTSIAHYDAETIPAKYPILAEQILTDTNKGRRSLNQLMIAHLHTIWQNSFSSGVAVLQPLGAHTFTLVKPAKDLAGLLAECPASILQSSCPPNRPKCSPCIGSRFRITVAPSFRNTSSLFTISIVPHPYTMATLANRSDVLTVAHIRRHTQRDPWITAVTRDILGDSRGGPSRVVSLKDAVASEYGSSRSLWFTTEYFPASFWPPPPPPKSPTNDAHPKVERIAPFPEHWLEHLDWHFGFPIPRTTVSHGESLPPVPAPHRWAKFPPGLPEERKKGSDPVPPTEEQAAIEVDLLLKAAKTIRSKNEDVLRIRRVAEAWNLADTEAWKFVKSFRARQLVERLKFEEEESAYVTGGVRGKSRWWGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAR4</accession>
    <name>A0A0D2BAR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450 oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236244.1">
        <property type="nucleotide sequence ID" value="XM_016380417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAR4"/>
    <dbReference type="STRING" id="91928.A0A0D2BAR4"/>
    <dbReference type="GeneID" id="27333162"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06079"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF190">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="52215" checksum="7B9FE59F258FB415" modified="2015-04-29" version="1">MAQLQSLVANVKTVSPLLAGCGLLGIWVLFQLFSYLRDPLRDIPGPLAARFTRLWYLKEVACGRFEQTNIALHRKYGPIVRIAPHYYSIDDMNAISTIYGHGTHFVKGKWYIASATPTSKVPNLFTELDPDVHSAVRRKVASLYSMTSLVAMEPNAVECARLLAEKFTALAESRKPFNLQVWLQYFAFDTIALITLSKRFGFLDTGEDNGGMIDALHKYLLYLSKVGVIHEWHSTLNWILSFMPKQGMHYLGSFMIDQVAEGQRQRPKGSLEKDESKPTDDFLTKLLRMNALQPEKFSMEDVYSICMTNIGAGSDTTSVSLAGILYCLMKNPEALDKVRKEIDEAMEGCGPDEMLSFQETQKLPYLQACIKEGLRVHPATGLPMVRVVPKGGSTIAGRYFPAKTEVGVNSWVAHANQRIFGPDADKFRPERWLESAERTSDMNRYIMTASSPKRWGKTCTNWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAT2</accession>
    <name>A0A0D2BAT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236274.1">
        <property type="nucleotide sequence ID" value="XM_016380447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAT2"/>
    <dbReference type="STRING" id="91928.A0A0D2BAT2"/>
    <dbReference type="GeneID" id="27333192"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06109"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF103">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="56119" checksum="B41DE29C79879812" modified="2015-04-29" version="1">MLYSYLALLVGGAILATVIYNRWFHPLSKFPGPFLASQTDLWRVYQLTTRHMPEKLLKLHEQYGPVVRYGPNELSFWGVKAINPIYKSGRKVLKSDFYDGFTTFYQNLFGTKDEELHAKRRRQMAHSFSIASLAQMESIFDRRINHLVRTMDSFGAAPFDLKELIGYYTYDLMGELIFNAEFGTMETQDPKGLPPINEHIFLGCIYGMLPSLLPYSMRLAPRVPLPWLQHLLAGRKKLRDQTATHVAVELAKDKTEVRHNILSRLTQATDPETGEGLTEAEISSEAFAFLVAGAHTTSGTLTLLLYHLLHNPTAAKKLTEELNSPLFLQSPDPRNDQSSPSYSGLEMQLPYATACIRESYRMSPVFTMPLPRTICDPLGADIDGHHIPQGANCSITNHVLHHNPEIWGDDHDVFRPERWLEEGNTLSPNDLLPFGAGHRGCIGRNIASMSVVKVLVTLWRRYELEAVDVDGDEKLVMESVGIGEKKGPLVVKARARTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBT3</accession>
    <name>A0A0D2BBT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_06111</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236276.1">
        <property type="nucleotide sequence ID" value="XM_016380449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBT3"/>
    <dbReference type="STRING" id="91928.A0A0D2BBT3"/>
    <dbReference type="GeneID" id="27333194"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06111"/>
    <dbReference type="HOGENOM" id="CLU_002486_0_0_1"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="63"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="565"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="624"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1111"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="639"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1112"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW16060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1179" mass="133337" checksum="298A2E2162C0192B" modified="2015-04-29" version="1">MEKQSNKPHRPSKEKKKPQRGEKNVKAFAVANPGRLAKQAVRSSDINEKRLHVPQVDRIPEEAPPIVVAVVGPPGVGKTTLIKSIIKRYSKQTLSHPTGPLTVVTSKRRRLTFLECPSDSLAAMIDVAKIADIVLLMIDGNYGFEMETMEFLNALSVSGMPGNVFGILTHLDLFKKQSTLRMAKKRLKHRFWSELYQGAKLFYLSGVINGRYPDREIHNLSRFLSVMKNPRPLIWRNSHPYCLADRLLDVTPPTQIEENEKCDRQVALYGYLRGTNFPAEGARVHVPGVGDLSVREIEALPDPCPAPFLDQAMAKASGKASRRKLGEKQKVLFAPMSDVGGVLVDKDAVYINVKTNTFDRDADDGEERGLGEQLMMSLQGERRLLGEVDGGVRLFQGGRQLSEGDNNDNDTGRTTKRGIRSFGQDSPHDGVDQEEDVDEGFVSGESNDELSDDEQVIDFPEHTGRPGIVEEEELDEEQGAGELEFADSDSDLGSISGDNQNDQDFTDEDSEFDESEDDGGLRWKENLSEHARKSHSTSVAFRAADLSRLMYDLTLTPAEAIAKWRGEQSHQTNTEHDEVDDEDNFFNKAKTEQEEELQDRQTPRYVYEDLAQKWEDEDNVQSIKSRFTRKSLATGANADSDEDEYGGFDEDAGDDSDEGDGEFEDLEAAPEQDSEAQTELTLEEERIKNAKRKEELKLRFEEEDREGFANGKSEVKATEQEFGEDEWYDAQKAMLQKQLDINRAEFDSLDPVARARAEGFKAGTYARIVLDKVPYEFVRSFNPKLPVIIGGLAPTEDRFGFVQVRIKRHRWHKKILKTNDPLIFSLGWRRFQTLPIYSISDSRTRNRMLKYTPEHMHCFGTFYGPLVAPNTGFCCVQSFSNANPGFRIAATGVVLNVDETTEIVKKLKLTGYPYKIFRNTAFIRNMFNSSLEIAKFEGASIRTVSGIRGQIKRALSKPEGHFRATFEDKILMSDIVFLRAWYPVKPHRFYNPVTNLLDAPPSGPANTDGEGQRVDDGSEGWQAMRLTGAVRASMGIPTPLLKDSAYTKIERPNRHFNPLRVPRALAAELPFKSQITRQKARKAPTYLQKRAVVMGGEEKKARDLMQKLQTMRNEKAEKRAKKQEERRAVYRKKVAENMEKKEEREKRERDEFWRKEGRKRKHAEAGGGGGGGRGKRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCI1</accession>
    <name>A0A0D2BCI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06386</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236551.1">
        <property type="nucleotide sequence ID" value="XM_016380724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCI1"/>
    <dbReference type="STRING" id="91928.A0A0D2BCI1"/>
    <dbReference type="GeneID" id="27333469"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06386"/>
    <dbReference type="HOGENOM" id="CLU_004909_0_1_1"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="140"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="690"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="690"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="779"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="830"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="912" mass="104027" checksum="FADAA454DBE6467B" modified="2015-04-29" version="1">MAMQAPLANDKKRVKVYELRDNDWFDRGTGFCTGQVVNDEPRIYVESEDQPDHMLLETKIVKDDGYQKQQDTLIVWTETNGTDMALSFQEAEGCAVIWEFVHQVQQQLMSLPDDGLSDDALDSISTSFTLNPPELNNLDEIEQNIRQASITQGGREALAKFLMKEHYVEKLIPLVEMAEDLESLQDLHRLCNIMKALILMNDNTVIEHLVTDDIIIGVVGALEYDPDFPTHKANHRQYLSDESRYKEVVEIKDPNIKRKIRQTWRLQYLKDVVLARILDDPTFGVLNSLIFFNQVDIVQHLQNNTSFLKELFAIFSPENADVKRKEQAVHFLQQCAAIAKTLQMQARANLLNNFIAHGLFSVITFAVKHPEASMRTTGIDILVALLDHDPNMMRGYMLKAVHEKKTPLTDTLIDLLHAETDLGVKNQLADAIKILLDPQPPSNDPMGNRQNSEFMTKLSRPPQMTDAQQKREEFAQENFDRSCRKLFKPLKDLEFRESLQNFSYQEVSLFSYLVEILTFFVRQHSIRSRSFIISENPPPRVAQLLQVPQKPLKLTALKFFRTCVSLQDQFYAAQVIKSGALGAILGIVIDTMPRDNLLNSACLELFEFIKREAIKPVILHLGENYRQQLQDITYVDTFEQISMRFEQLTVDHPEPDHTLFSQDDATPPMNRSHVNGRWQGLQEMDANEEEYFNTSDDEEDEHEGDADRESMKDVSERMQWHRKRMKSEMMNGAASPISKPLVDYPDDEDDENTDTKSATPQTPPTPESSKDVSSPENRAISDKKLQPSPEMKETELQHPPERLIEKRRRQEDDEEDELGKLTGGPKRRNSSSSATSLGSSGSLKRKKGFLRSKQAADRSVLSSNDDSENHVEARKTRKIAISLSNAANKSDDPSTTNTTTSSEQNQAANTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BD09</accession>
    <name>A0A0D2BD09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_06545</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236706.1">
        <property type="nucleotide sequence ID" value="XM_016380879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BD09"/>
    <dbReference type="STRING" id="91928.A0A0D2BD09"/>
    <dbReference type="GeneID" id="27333628"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06545"/>
    <dbReference type="HOGENOM" id="CLU_004134_0_0_1"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000320">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057213">
        <property type="entry name" value="DUF7891"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25421">
        <property type="entry name" value="DUF7891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="883"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="260"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="438"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="805"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="818"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW16490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1146" mass="126778" checksum="9183E64AB5A63363" modified="2015-04-29" version="1">MTHDGQDSHGNNPPPVSPVLRSSTLDVQPLRIPKNKSTSNLPLAGNDASVFPSFNPRTRFSFDAGTAQEISNLKRATRFDHDLGKSGLRRIRRLGPSLRAPSLVLGDGDFLASPIERSKTMPMSGSSSRSVSTGQLLSGPTSPVIEDLHRFPSESLHSFSFAKQSEEFLHSRQNILQRSVDFVRDRSQWAANPALADAQARASGNVEVQGMMALLKKANLIPVDTGRANSRGVGAGPLTGPAHHDGRNIFEKSFSQELEHAQKQAGVQYAEDQSAGRKYSIDDDEDEEALREPDLEMRIPPSRSDSMSAPRRTALRRTYTDVHSVSLQQKLIEALAQPYSTDEVSYPQGATTMSRTSVPPTPSVANPPNVHSHSSKWSPTHQAVFRTEGDAPWTILAANDLACLIFGISRAEVRSLSILGIIQEERRHWLETRLARPEEPAESIRPTTFKNGTGSGSMSSIGSKSGITARLLSKAPSRANKSSDKRAKTVDGSGGYSRSKSNNHPPTKSRGVLLCGDIVPVQRRDGTKGAASFWVMEKRGGLIWVVEEIAEDVAYVNVDDDGTVKGAYGDTEAIWGQSNLEGAPLQSLLPKFPLNTMNSSEKIHPGYYTARTVDHFNVPTTVEKSPTENQLRVSSLPHIAGVMVLNPANLKISSSNNIFAAALFGYEKPEGLEFTSLIPNFGDMLHILASEDDVQLSDGIVIPEHSFRRARGLLALREGNENPSDIFLRPCGLPAKHHDGSDIMVDVQMRVVRSESLFPMSDDAIIEEKEDEEGEDLAGSGVAVAELVYAVWIIYSRNIHSTSMGGSITDHEPQSRPLSPPSQPEPPTSIPSPPPRTSTDSPRVLSPSDEPDETDSVAMDEPLDHPPPHTPYVPHERKTIEDFTILEEMGSGAYGQVKLARYKRGEARKMVLKYVTKKRILVDTWTRDRRLGTVPLEIHVLDYLRGDGLRHPNIVEMIDFFEDDVNYYIEMLPHGIPGMDLFDYIELRTNMTEAESQSIFRQVVDAIHHLHTKALVVHRDIKDENVVLDGEGRIKLIDFGSAAYIKNGPFDVFVGTIDYAAPEVLQGKRYGGKEQDVWALGILLYTIAYKENPFYNLDEILDHPLRVPYLPFSEECLDLIRKMLDRDVEKRITIEAVRNDVWLEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BD15</accession>
    <name>A0A0D2BD15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237079.1">
        <property type="nucleotide sequence ID" value="XM_016378402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BD15"/>
    <dbReference type="GeneID" id="27331136"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04053"/>
    <dbReference type="HOGENOM" id="CLU_1927613_0_0_1"/>
    <dbReference type="OrthoDB" id="4160024at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="131" mass="14935" checksum="DF1B1603DC3B115D" modified="2015-04-29" version="1">MAKATPPSPRNFQFRRLLDNLEYKFHRQTGLAKDSVYVRSDMAVRVIYDLDFGWSIWADGGDGDNHHHADGADDNCLSNPNPPPRPSRRRGSLVGRVWDVPVKDQGDHPPIGVWVSRKGDKSYVYLLEYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BD45</accession>
    <name>A0A0D2BD45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TIGR00730 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_04078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237104.1">
        <property type="nucleotide sequence ID" value="XM_016378427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BD45"/>
    <dbReference type="STRING" id="91928.A0A0D2BD45"/>
    <dbReference type="GeneID" id="27331161"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04078"/>
    <dbReference type="HOGENOM" id="CLU_058336_1_0_1"/>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000018">
        <property type="entry name" value="Lysine decarboxylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27125" checksum="49BED7A73558445F" modified="2015-04-29" version="1">MSSTQVPQGPESEGKKPVVCVFCASSPGKNPIHLESARTLGKALHEAGYNLVYGGGTMGIMGELASTLVSLSGPRSVQGIIPRALIKSELVVDPSGTKTARKTERTMTAQQLRRIDSNDDPDSQIVPESEFGATRIVPDMHTRKSMMARAVEAGAAGSGFVALAGGYGTIEEVMEMVTWNQLGIHKIPIVLVNIDGYWNGLLDWVRNSIREGFVAEGAANILVEVKGTDEVVQALRDYQLAPGRYKLDWSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE04</accession>
    <name>A0A0D2BE04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_04389</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237414.1">
        <property type="nucleotide sequence ID" value="XM_016378737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE04"/>
    <dbReference type="STRING" id="91928.A0A0D2BE04"/>
    <dbReference type="GeneID" id="27331472"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04389"/>
    <dbReference type="HOGENOM" id="CLU_017947_3_1_1"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW17198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="552" mass="61465" checksum="62BF481587E043A0" modified="2015-04-29" version="1">MPGFSQATELKAWQALVEHHNTVGRNIVLKEYFEKDPQRFEKFKRIFKNDADNREILFDFSKNFLTEETLDLLINLAKEANLEQLRDEMFAGEKINFTEKRAVYHVALRNVTNQPMAVEGKSVVEETNSVLEHMKEFSEQIRSGEWKGYTGKKLTTIINIGIGGSDLGPVMVSEALKPYGARDMKLHFVSNIDGTHIAEALKDSDPETTLFLIASKTFTTAETTTNANTAKKWFLQSAKESDIAKHFVALSTNKEEVAKFGIDTKNMFGFESWVGGRYSVWSAIGLSVCLYIGYDNFHEFLAGGHAMDNHFKTAPLHENIPVIAGLLSVWYSDFFGAQTHLVSPFDQYMHRFPAYLQQLTMESNGKAVTRTGEYVKYTTGAIFFGEPATNAQHSFFQLLHQGTKLIPTDFILAANSHNPVEGGLHQRMLASNFLAQAEALMVGKTPEQVKAEGAPDELVAHKTFLGNRPTTNILAELITPGALGALIAYYEHMVFTEGVIWNINSFDQWGVELGKVLAKKIQKELETEGAGADHDSSTAGLLAAFKAKNGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEE3</accession>
    <name>A0A0D2BEE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_04557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237579.1">
        <property type="nucleotide sequence ID" value="XM_016378902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEE3"/>
    <dbReference type="GeneID" id="27331640"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04557"/>
    <dbReference type="HOGENOM" id="CLU_505292_0_0_1"/>
    <dbReference type="OrthoDB" id="4114642at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW17363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="539" mass="60636" checksum="C847BC9C72744BAE" modified="2015-04-29" version="1">MAGGNPTFINVSQREYSEQSWRGRQLAVVQSHSASLRHGRRNQQALNDLTAAPLEIAAALRPHGKTVQHPQCLSADSLEVRHTQRQLQRIALHDGSTQDDSVFENTEQEDLSFEDLNKIFQLDGNVSERECSRTICNAEPTETLPVLMERPYDIHQRLPQRNVPLRSSTATKCTTRPSRPQIWASQAAILQGTDNDHGPRPTDGQGSAHYIFPAISEITSSLDPFIRLPVQVSESDKSLLHFSSFPRKALTIMYLAMLEYVSGRQDLQEMHIQALDDFVESNGGVAIFRTRSESPEILLCSARSYVTQFVRAEVCLPTISRLQSTVSRYLDSLAQVHRWASNFRAQLSSEAVSLPHYRLRLRPLIDYLGHLGQIRTSVESTRVWDAASGAHFCVYSLVITLVEFTHSPEKVFEFLEQVQECMMASVDKGLQNESDLDGLHPFSTGQMIGYVRTLMFRDVGDVKEIRICRAQADAQKVFALLSQGRRDELVSYFVGSVLALDRTSRTIGDRDVAASATSRQKLSAEILKAWALQQRMHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEN4</accession>
    <name>A0A0D2BEN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_04226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237251.1">
        <property type="nucleotide sequence ID" value="XM_016378574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEN4"/>
    <dbReference type="STRING" id="91928.A0A0D2BEN4"/>
    <dbReference type="GeneID" id="27331309"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04226"/>
    <dbReference type="HOGENOM" id="CLU_007884_0_0_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF15">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="498" mass="55904" checksum="A4D098244485A0FA" modified="2015-04-29" version="1">MVSQDSKIIIVGAGVFGLSTALWLSRAGYKNITVFDRCPLDTKNYNPSDGCDGASADINKIFRTAYGTEKEYQNLAIEARELWLSWNREISESSPSALPPGLTPDDKVLDLCGNFFLAEGQELQKFHKDSLSLMEKLEPECRKLQFVKGDREDEERLRQLHPNWVETFHAIDGINNNNTNGFLDIQGGVTLADKACTYARFLCEKAGVRFVLGHPQGQLQELIVANEGSGNKVTGIQTCDGKSHHGDIVIVACGGWTASVIPEAARTVETTAGTLMFIDVPKERKDIWEMFDSKHFPAWSYRRGEGDEYYQGGGFPITKEGRLKFGFRGRKFTNFQDHPTAPNLRVSTPRTKYTPDPIKTIPLYGLQLVKEVIGKAFPELAEFGFTDFRLCWYTDSIDNDFVIDYVPGYSDTLFICSGGSGHGFKFLPILGKHVKNQLERIPDQFTDLWKWRVVEDGKICNGLEQGEDGPRELSKTQMAEPRDFKFLQPKAPALQSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF13</accession>
    <name>A0A0D2BF13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_04737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237759.1">
        <property type="nucleotide sequence ID" value="XM_016379082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BF13"/>
    <dbReference type="STRING" id="91928.A0A0D2BF13"/>
    <dbReference type="GeneID" id="27331820"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04737"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF103">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="56876" checksum="035A96BD01AF3AD9" modified="2015-04-29" version="1">MRIQILDFVHQLGWRALPLAGILAIVVYVVYLRYFHPLSKYPGPFLASVTNFWKFYQYSTLRFPNTLIKLHEKYGPIVRIGPNDLDFNYPEAIAPIYKTGKKMPKGVFYNAFTSFVPNIFGTTDEHHHALRRRQTAHAFSVNALKSMEPIFNQNISNLISKFGACADSAAIVDLKIVFTYYAYDLTGKLAFNEDFNTQVTDDENLVPPFSDHFLLGNMYGSVANLLPWIRDWTAWHPFVKRIIQSRRQMGLQAARCVNKAIAHHKKDESVRTLLTSLIDAKDPETGATLTADEINSEAFGFLVAGSHTTGSSLTVLFYYLTHNPHVLAKMVKEIDERISDDQEVYDFAGLESQLPYTLAVIRESFRMSPVAALLLPRVVIDPQGMLINGQLIPQGTNCCMVSTVIHHNHKVWGPSHDVFDPDRFYPESPIYDPALAGYLMHFGQGYRQCIGRNIGLISIWKIVITLFKKFHFEAVDPNEPLILDHTGAADKVGPLLVRVTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGY3</accession>
    <name>A0A0D2BGY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230810.1">
        <property type="nucleotide sequence ID" value="XM_016385866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGY3"/>
    <dbReference type="STRING" id="91928.A0A0D2BGY3"/>
    <dbReference type="GeneID" id="27338641"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11558"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="327" mass="35627" checksum="FF96689E4403CDE0" modified="2015-04-29" version="1">MSSSMEAIVIPRFGGPEVLEIQQVPKPVPTLGEVLVKVRAFGINHAEMHMRKGEWDEWNPITGLECVGIVEACPGDEFSVGSKVIGVMGGMGRNRPGSYGEFVTVPVTNVARVETNLPWEELAVVPEVYSTAYSCLFTVLDVKAGESVLIRGATSTIGQAAVNLAVNAGVKVTATTRREGRFKMLKEMGVTEVVLEHDNLASEFPAGTSFDKVLNLIGNRALLESIELVRAGGRMLQAGWLGGLAPVKDFNPMVQMKPGVHFSLFHSKVLGTAEFPLSRIPLQEIVDKIEKKAWDAKPTYVFDWRDIRKAHELLDSHNAGGKIVAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHR6</accession>
    <name>A0A0D2BHR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238386.1">
        <property type="nucleotide sequence ID" value="XM_016376816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHR6"/>
    <dbReference type="GeneID" id="27329541"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02458"/>
    <dbReference type="HOGENOM" id="CLU_127770_2_0_1"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.110">
        <property type="entry name" value="Protein of unknown function DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466:SF1">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="169" mass="18629" checksum="DFF82BF553A9598C" modified="2015-04-29" version="1">MGLPNQTSSKEMVKNKNKNVAGGLLAPLTKDYPVGYYRDGYCRTGPDDPGNHSVGATVNQEFLEFTKSKGNNLEKAGVKDGMRWCLCATRWKEAFDAAQRGHLAQSAVPQVHLHASHDKALEVLQYSDMRKYSHGGEVPAGQNRNRQADYHSGDTRRGIVKESSEISGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIE6</accession>
    <name>A0A0D2BIE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231350.1">
        <property type="nucleotide sequence ID" value="XM_016384748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIE6"/>
    <dbReference type="STRING" id="91928.A0A0D2BIE6"/>
    <dbReference type="GeneID" id="27337517"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10434"/>
    <dbReference type="HOGENOM" id="CLU_000288_144_2_1"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="23"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="70"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="526" mass="58029" checksum="D877FE35791DEBCE" modified="2015-04-29" version="1">MGSKAAVAETAPSRPIAMVSLDGGGVRGLSSLLILRMLLILVTEELAKRNAIPKDRTTLNPQDVFDIAVGTSTGGLIVLMLVKLNMSIDECIEQYKILSGRIFSKERSAIKRVFGDWSKFSGRELQKSIESLLASRGHPPDLKMRSPHPNSMQGTVLCHERPNPHPIFFCTHECQGPYRQQILDCDLELRQAARATSAAPSYFEPMIIRGRSFTDGGLGETNNPSWEGKLHYHKNHGLNEDEQLVMINIGTGTLPQEFFQQPLPTRPWWAKLIPNGVVDALGLVADLVKIATESEQRAIDLSYISSIIPNQFFFDRFSADTGLHHIKLDNWRAVKDTDGPSEIETKTNAYLKKPEVRDRLVIAARRLADVYVTRNNKPVSRSSTLSEEIASVLPQGSSLEDVARVDLTIQLGYDTPSERLQSPGRRSIVLNHPSAEKAPSLITGSDPTRSAETSQPPTPNPAPKSLSNHHEITVEPEESDLQGEGDQFDGTKDVPITPLFASSGRSPTRKPKRASTYPPRSSPVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIL7</accession>
    <name>A0A0D2BIL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_10509</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231425.1">
        <property type="nucleotide sequence ID" value="XM_016384823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIL7"/>
    <dbReference type="STRING" id="91928.A0A0D2BIL7"/>
    <dbReference type="GeneID" id="27337592"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10509"/>
    <dbReference type="HOGENOM" id="CLU_015846_0_2_1"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000059">
        <property type="entry name" value="Serine palmitoyl CoA transferase subunit LcbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="123"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW11209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="508" mass="56604" checksum="87D7203FCC153444" modified="2015-04-29" version="1">MDSQEPQVYLAHLANAASEQFHKIPGSAIFLRYVQSSYQNDPVRSAVELFLVLFAIRYLLAPKYSTKPNYVKLSEEEIDDLVDEWTPEPLVAKSTPFEEAELEKRPVIVGPSGPRVKLANGRTVTNLASYNFYNFVSNETLKERAIQTLRTYGVGPCGPPGFYGTQDVHMKIEADIAAFLGTTACIIYAQAFSTISSVIPAFSKRGDIIVADKAVNFAIRKGIQISRSTVRWYEHNDMEDLQRVLAKVTKEQAKKPLTRRFIITEGLFENVGDMVDLPKIIELKLKYKFRLILDETWSFGILGRSGRGITEHQHVDAAEVDMIVGSMAGPLSAAGGFCAGSDEVVEHQRLSAASYTFSAALPAISAVTASETLMMLQTQPELFAQLKDNIRTMWAQLHPRSDWMYCTSAVENPIMLLILKPEVITARRLSLEDQQQILQDIVDECLTQNVLITRVKSLPAGPSGAKTDIYMQMPALKVCVTIGLTKKEVEKAGIIIRHAITKIMTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ90</accession>
    <name>A0A0D2BJ90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238866.1">
        <property type="nucleotide sequence ID" value="XM_016377296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ90"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ90"/>
    <dbReference type="GeneID" id="27330022"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02939"/>
    <dbReference type="HOGENOM" id="CLU_002639_8_3_1"/>
    <dbReference type="OrthoDB" id="4121234at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="269" mass="31064" checksum="AAEFFCAAB8DB36DA" modified="2015-04-29" version="1">MLPELPEYVALSHRWGKIMPLTLRKNDVETFKSGMPLSKLPKRFQDAVEIARWMDIDYIWIDSLCIIQDSDADWSSESSKMGDIYANSYCNIAAPGDDSQKGCFADRPIEMLEPSSVSEPGFGDVEKTHILGYSDFWSNSLLDMPLHRRVWVVQEQVLSPRTVHFGQDQIFWECRETKACEAYPHGIPEAFCNWRTRDWGKLDEEVISSRTHPEDARVQPQPQLLQRLYAFLTSPLRLLCKSTATPQTPMTYGLWGKTFGRYRKFKLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJS8</accession>
    <name>A0A0D2BJS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239389.1">
        <property type="nucleotide sequence ID" value="XM_016377819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJS8"/>
    <dbReference type="STRING" id="91928.A0A0D2BJS8"/>
    <dbReference type="GeneID" id="27330549"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03466"/>
    <dbReference type="HOGENOM" id="CLU_010119_1_1_1"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF812">
        <property type="entry name" value="2OG-FE(II) OXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="169"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="388" mass="43200" checksum="38601D2DD066B567" modified="2015-04-29" version="1">MSFSSIPILDLSLARDPATKPQLLADLRHALLEVGFLYIKNTGVPPALIDEVISLGKSFFELPEEKKLAIEMKNAPSFLGYSKLGMEITRFKTDWREQIDLSTPHEAPGPNDPLYRNLLAPNQWPDPKALPRFREVYEEYMARMGEMSMEFTSLIAEAIGLPADAFAQFFDEAQQHKLKIVKYPDLEELGVEGEAQGVGPHKDSMLSSYLLQASHHRGLQVQNAEGEWVDCPPMDGTFVVAIGQGMEALTQGVCQSTTHRVQSPPRGSGARYSIPFFQGVSYDATFESMDVPESVKKLRADILARRGGQRLDDIEFTFIKGMWSKLGEATLMNRVKSHPDVGERWYPDLLKKIREDQAEEAAKFAAKEAAATSSSSSLPTQPQSIQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKK0</accession>
    <name>A0A0D2BKK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239311.1">
        <property type="nucleotide sequence ID" value="XM_016377741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKK0"/>
    <dbReference type="GeneID" id="27330470"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03387"/>
    <dbReference type="HOGENOM" id="CLU_647292_0_0_1"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239085" evidence="1">
        <location>
            <begin position="22"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="424" mass="47074" checksum="A7618F3D3A169B88" modified="2015-04-29" version="1">MTPSQLSLFNTLSYILASTLSESDSSTRRQQDTYDHLCSLFQSRCPQQNPAIYGNPNLRFFGSPVGVGAESVQLTRNATEGHILLQAGRAHGVTHGDLFFAYPFHQNEGGPKNLSSQPLRLCVVKVGGLTSMCEVFSQGPSQPEIQTGWKARWQKRMALQQYPILVLGSNELLNDWRTESARRTSLDIRYEDSGNITFSFYVTLSGHGYYEIRDQLHETIDKVPTIGNIGSGSGLEHILEAIEHLVWFKHVKSIVNQSPSANFKKSLSIRLTAPSDKDIDPTEMAEVRDGDRLVLEVKNLTSSALFLYIYHLDSSWQIQNIVGGAYMTIPAQDSDKNHLGVTQKVLKMSIPPEVKREGHGYCDDVVKVFVTARPVSFAYLETPKLGVSAKADPQGGIPVAVQDPSDTDESDWVTVNFQIRTIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKQ5</accession>
    <name>A0A0D2BKQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239391.1">
        <property type="nucleotide sequence ID" value="XM_016377821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKQ5"/>
    <dbReference type="STRING" id="91928.A0A0D2BKQ5"/>
    <dbReference type="GeneID" id="27330551"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03468"/>
    <dbReference type="HOGENOM" id="CLU_034597_0_1_1"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="73"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="314" mass="35488" checksum="A6B3CBD27171068A" modified="2015-04-29" version="1">MLSTDGGGSVPLDPMTLHGSFTRFCLQYHLASLPLHVHQVLIAFLTYEVLFLIVAPAFSLVFLPQTYGKLPRRTKTNWNVRVTSFIQATFICYQALRVITQDTSRQNTDYDARLWAYSRGSGDAQAFAAGYFLWDVVVSVQHFQILGPTSLIHALSALMITSLGFRPFANFYGVNFVLYELSTPFLNIHWFLDKLGKAGGRYQLWNGICLIITFFGCRLVWGTYQTINLMADTWRAWGDVGTGKCLDAFMTVRAEGSQIAVPVQDFCYDNFPSGLLLTYIISNTLLSGLNVYWFGLMLKALGRRFNKNVDKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKR9</accession>
    <name>A0A0D2BKR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239411.1">
        <property type="nucleotide sequence ID" value="XM_016377841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKR9"/>
    <dbReference type="STRING" id="91928.A0A0D2BKR9"/>
    <dbReference type="GeneID" id="27330572"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03489"/>
    <dbReference type="HOGENOM" id="CLU_065389_3_1_1"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26510" checksum="7167C952FF0599EE" modified="2015-04-29" version="1">MSTVLDHDFLKHLAAIHDHAPGHQPPRLKWYLTTIIAFGGMNYPELIPELYQILLREHIHEEEQMQETRKIREGLTKICGIWGAAKTGSATRQLSKATPPRLKDPTVYRSREPQEVAFKRGQEMLDQIYKRIPGYDMSLVSEASPDYGWIVNNLFYGHVFSFPDILDAVETGQCVVAALFSTDCQEQVRNHMLGMMYSGATRGEVEGIRAVVMAVADKLGVVGKQGRRAIEVPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKV3</accession>
    <name>A0A0D2BKV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_00131</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239774.1">
        <property type="nucleotide sequence ID" value="XM_016374498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKV3"/>
    <dbReference type="STRING" id="91928.A0A0D2BKV3"/>
    <dbReference type="GeneID" id="27327214"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00131"/>
    <dbReference type="HOGENOM" id="CLU_017097_0_0_1"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058758">
        <property type="entry name" value="UBA_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF42">
        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26112">
        <property type="entry name" value="UBA_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="264"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW19558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="643" mass="72285" checksum="299D39B04B350FA3" modified="2015-04-29" version="1">MWLSSKSSKRSANSSPSPRCTSQSTSTSPGSTLAEVLRKNPFRGGSRESLPRQHEDDPSISRNRDLAILADLFPDVKLEVLRELLVRFDGDSRLPICTEQLLKYKVEWARGRMNIPPRTQEDPISVEDQFRSREYVDAVKWTLGREFNGLSRSAIDAVLAEVNSSYTLARPTLQAIVNRSWRNTFTSLFKKRKPSREPPSILLERPKTATSPARLLTTGNPELDEELSVLFTGSVQAAEKDRQQTIDLELALALNLREAEEAGAIFECQVCYNDVPFEDVSACTHSGHTICLDCVRRTLHEAIFGQGWAKSVEVGRGTLKCLATDSCDGYIPPDLVERAVLREKSGTETWTRFEDRLAEDNLQKSGLPIIRCPFCSYAEATQVYDRNSAAELTWHFRWPTGINIFVFIMMLELIPSIACIILPFLLIFPGYFLALFYTALGHAASRRRTSRFTCRRPSCSRKSCLKCLKAWHDPHVCHEPLILSLRKTVEAARTAAVKRTCPRCGTGFVKSSGCNKLTCVCGYSMCYLCRKNIGKAGDNTEGGEGYRHFCEHFRPTPGMKCSECDKCDLYRAEDEDAQVKSAGEEAERLWREREGMVGVKGLEDAVGNVAGEDTIWRRIWDGRWTIQGVVDAAVERCVFVDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLF0</accession>
    <name>A0A0D2BLF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239994.1">
        <property type="nucleotide sequence ID" value="XM_016374718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLF0"/>
    <dbReference type="STRING" id="91928.A0A0D2BLF0"/>
    <dbReference type="GeneID" id="27327436"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00353"/>
    <dbReference type="HOGENOM" id="CLU_1652165_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="160" mass="17262" checksum="1407D553EF8B533B" modified="2015-04-29" version="1">MVVDCEVLDVQTTPKETEVSFGTTTAGFMILAGPAVQVTLHQEIPGHQQSRECFMSLAQTPRKSPTIAGEGEDYERGLSLELGSQGTGWQPFQLDVSAAVDNLQAVCIAIEKWHPRINSGQGTCLVIQAVSGEASYSRLEVSFGPASWVQVARRTEVKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNM7</accession>
    <name>A0A0D2BNM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240351.1">
        <property type="nucleotide sequence ID" value="XM_016375075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNM7"/>
    <dbReference type="STRING" id="91928.A0A0D2BNM7"/>
    <dbReference type="GeneID" id="27327793"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00710"/>
    <dbReference type="HOGENOM" id="CLU_048446_0_0_1"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW20135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="483" mass="52665" checksum="F91CF76BD09A0121" modified="2015-04-29" version="1">MPATDSAAVVVARFLKANHYNETLEAFLLESGLPEEAAITKKGDWTIEKILEEKRQYDSSLEYEKKGDEQMTGWPLPTPSIATEPGFQVTSNVLCVSGDGNGESEDSIIWATGADRSWSSMIPSPPFSLVESISNAHGSPILSISSIAKRFILSTSMSGQLMIHDNSGRLLDKCRDHLKYAVRVVSGRTRDGKWIVATAGWDQKVHIYAPEYELAENFNVNELNAADEGPYIDGLLRDPIHTISMPSNPESLVLIRHPDSDDLYLIVSRRDSTFLYYYCITPTSDEASSSRTSEATYSVQETGKQNLAPHANAWIAFSPACLAVCPTDPTLLAVATSHLPHMKVIIVRLLFPSSSYNPGSNSAAVSGPSEFVTPAAQARADLALQDREDAAIKLHVTTMAPQTPYSNPQVVWRPGGHGVFVNADDGVIRGIDTQSGKVIAMLKAHEIGSKVRTLYAGWEQGGKNEMLVSGGFDKKIVVWRVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP84</accession>
    <name>A0A0D2BP84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233120.1">
        <property type="nucleotide sequence ID" value="XM_016382417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP84"/>
    <dbReference type="STRING" id="91928.A0A0D2BP84"/>
    <dbReference type="GeneID" id="27335174"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08091"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="334" mass="36687" checksum="45143CAEF66A13AA" modified="2015-04-29" version="1">MLHVLSVPFHKLKVPPRASFQGQTVLCTGANTGLAREACRHALQLGASKVLMGVRTLSKGEQAREDVLTSTKAPKDAVEVWPLDMESFESVKTFARRVEDHINAGGRLDVAILNAGLATGKWSQTRDGWEKTLQVNDLSTALLSLRLLPLLERSSATNPHLVIVASDIHFMLNLKNNFQERHASDILQALNDRQRFERGQAANPAERYAVSKLLDIYIAIEMAALASKHKSKVVVNCVTPGFCKSDLLSPARGEKAPLVLRILQRALARDVVEGSLAYIDAALKGPESHGMFLENQVFTDPGSVVTGEDAIRTRQKVWGEIVEVFKRDDPTLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPE6</accession>
    <name>A0A0D2BPE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_01391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241029.1">
        <property type="nucleotide sequence ID" value="XM_016375753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPE6"/>
    <dbReference type="STRING" id="91928.A0A0D2BPE6"/>
    <dbReference type="GeneID" id="27328474"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01391"/>
    <dbReference type="HOGENOM" id="CLU_020639_0_1_1"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000132">
        <property type="entry name" value="FMN dependent dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF75">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_4G07050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="110"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="335"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="358"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="422" mass="46949" checksum="B9BDA92E51FB1B1B" modified="2015-04-29" version="1">MDPNNPNKEFRSTPEYAEYQRDNFWADNEGRVPPLNTHPDKLEERAKEKLTEGGWYYASSNAGLSTTHLANRQAFYRHRIIPRMLVDTNKRDTAWEIWGHKTSAPVGFAPIGINKIYHHLGELPVATVAKELNLPYCLSTAGSTPIEKVGAANGEGPRFYQLYMPHDDELTVSLLRRALDSGFTACILTVDTWQLGWRHDDVANSNYAFYHGIGHDLGLSDPVFQKRLAEDGIDPDKDPNRAGAKWIDNVWHGRAHSWEKMPWLIKTWKEMSGGKPFAVKGIQSVADARKCVEIGCDGIVVSNHAGRQVDGAVASLDALEQIVDAVGDKIYIMFDSGVRGASDVFKALALGAKFVFVGRLWVWGLSIMGELGVRHVMKGLLADLDILLNVAGYQNIGQIQGNREALESLPKAYSLIQERAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPQ0</accession>
    <name>A0A0D2BPQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="11">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_01070</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="11"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240711.1">
        <property type="nucleotide sequence ID" value="XM_016375435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPQ0"/>
    <dbReference type="STRING" id="91928.A0A0D2BPQ0"/>
    <dbReference type="GeneID" id="27328153"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01070"/>
    <dbReference type="HOGENOM" id="CLU_015846_6_0_1"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="13">
        <location>
            <begin position="180"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="88"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW20495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="609" mass="66205" checksum="E739507247E124CB" modified="2015-04-29" version="1">MEALLHQSKGVCPFLKKTSPATLRSLSTSTRQSPGGGTITNLQFIARRCPVMNKALAVQSARLGHRNYGKVATSTGVVKSLLEKKLHTSAEKKASVDTTMFRPAQQAPPPQKAQSSVKKPDTYAGPRPNAPPTPRFDYDAFYNHELEKKHKDKSYRYFNNINRLAKEFPRAHMAVPEERVTVWCSNDYLGMGRNKHVLKTMHETLDMYGAGAGGTRNISGHNQHAVALEKTLADLHGKDGALVFSSCYVANDATLATLGSKLPDCVILSDSMNHASMIQGIRHSGAKKMVFKHNDLVDLEAKLASLPPEQPKIIAFESVYSMCGSVAPIEAICDLADKYGAITFLDEVHAVGMYGPRGAGVAEHLDYEVYANPARTKESQRGSVMDRIDIITGTLGKAYGCVGGYIAGSAALVDTIRSLAPGFIFTTSLPPATMAGARTAIEYQARYQGDRRLQQLHTRALKDELTGRGIPVIPNPSHIVPVLVGDAETAKQASDMLLSDYGIYVQSINYPTVPRGEERLRITPTPGHTDDLRAELVDALENVWDRLNIKRVADWEAQGGFVGVGVKDAEPVQPLWTDTQLAHAAQVTEPEVADEATEERIMPIAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPX2</accession>
    <name>A0A0D2BPX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_01572</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241209.1">
        <property type="nucleotide sequence ID" value="XM_016375933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPX2"/>
    <dbReference type="STRING" id="91928.A0A0D2BPX2"/>
    <dbReference type="GeneID" id="27328655"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01572"/>
    <dbReference type="HOGENOM" id="CLU_001882_4_1_1"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="102"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW20993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="575" mass="64871" checksum="8DFEED66CEA0824A" modified="2015-04-29" version="1">MSHSREPSKTDLPTREKEPKVAAEKKMEKKPAPEKAIGKNEAKAPQSKGGKKKKEGALLIGIDVSKDVDFPEWYQQVLLKGDMLDYYDISGCYILKPASQFVWDEVRAWFDQRIKKMGVKNCSFPLFVSEDVLSREKDHIEGFAAEVAWVTHGGSTKLEKKIAIRPTSETVMYPYYAKWIQSYRDLPLKLNQWNSVVRWEFKHPQPFLRTREFHWQEGHTAHLTEQEAGKEVLEILDLYADIYEQLLAVPVIKGRKTDKERFAGGLYTTTVEGYIPTTGRGIQGGTSHCLGQNFSKMFGITVQDPNAKTEEEKKNQLHVWQNSWGLSTRVIGVMVMIHGDDRGLVMPPRVVETQVVIVPVGVTAKTTDEERDALYGEINGLVEVLKAANVRALADLREGYSPGFKFNDWELKGVPLRLEFGPGESKGHYVTTSRRDLPKAESKGQIAISELNTAVPELLETIQKDLYDRANAKYKSHIKQVTNWDDFVPTLNEKNVILMPFCLAESCEDQIKEMSARKAEEQSGVPQDERAPSMGAKSLCIPFDQPAGIEKGVTKCGNPKCSSFAEAWCMFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ16</accession>
    <name>A0A0D2BQ16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01597</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241234.1">
        <property type="nucleotide sequence ID" value="XM_016375958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ16"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ16"/>
    <dbReference type="GeneID" id="27328680"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01597"/>
    <dbReference type="HOGENOM" id="CLU_034754_2_0_1"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="53"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="351" mass="39759" checksum="B542FD1FACDCE903" modified="2015-04-29" version="1">MAANYWTSTQRKFWTFTPDKLVDIRDDLEKQNAKIIEQYPYPDRRHMMIFLRDRLLQLAKRLQFRQQCVATALVYLHRYFLSTPMQNVNLYLLAATAFYLASKTEESPHHIRLVAAEARQSWPEFIPGDVSRLGEMEFCLISDMRSQLIVWHPYRSLIALKENQDLKLSNDELGLAWSIINDSFMTDLPLTCAPHLTAVIAMFLAVVFLPTAKATGTLRPLSHETLSNPDNGPFSSLVGRQNLSGSLGGVLGNLQMSSQAALQNSSNGNGKARMPQSDAQPFDKEKAIATAKESEKMQNTMKFLVDSGIDIERMIEGTQEMIALYDAWEQYNEKSVKEIVSRCLKSRGLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSB2</accession>
    <name>A0A0D2BSB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234325.1">
        <property type="nucleotide sequence ID" value="XM_016381223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSB2"/>
    <dbReference type="STRING" id="91928.A0A0D2BSB2"/>
    <dbReference type="GeneID" id="27333973"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06890"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF86">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="502" mass="55350" checksum="5F2F78ECC080A7DA" modified="2015-04-29" version="1">MGAPSEMKAEIQPQHSSGDTLVLSEDALNVPGYEADLQYDAAEARKALLKVDLLILPFIVLCFCFLQFDRTNIGNALTDSMRHDINVGNSQINTAQTLFIVGFVVTEIPFNMISKYVGPERFLPVTMFFWGIVTWSQIFIKDASGLWAARFFVGALEGGYIPGFALYISKYYTNQELGLRFAIFWASNSFAGALSGPLSIGLLSLRGSHGLHGWQWLFLIEGILTCFLGVVAYFYLPHGPARPKAFFGRSFINFFTDREAKILVTRVLRNDPTKALRHGKPVLPQHILETFMDWRLYGHLVGAFLSMIMIQPMNTYAPSIIKSLGFSGLQANGLNSVGSVCALVWSVSLAFSSDKTRERGFHITVGYLWGAAGLLWLALAPSGVGKWVLYGGVVMTQMGMGSAQAISAAWLTSKMQDYKRPIALAAYVMSIQLAGFPGMQLFKSHDAPRYRHGLIIAASCAISGAVVILVWKLLYRLFDHGEGGVETQYGMPTTERRTASEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BUS4</accession>
    <name>A0A0D2BUS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235190.1">
        <property type="nucleotide sequence ID" value="XM_016382088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BUS4"/>
    <dbReference type="STRING" id="91928.A0A0D2BUS4"/>
    <dbReference type="GeneID" id="27334844"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07761"/>
    <dbReference type="HOGENOM" id="CLU_019655_2_0_1"/>
    <dbReference type="OrthoDB" id="3344043at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="630" mass="67272" checksum="9E53D41C7618F32F" modified="2015-04-29" version="1">MGRDEFPSSGHGRRDSDLPSYPPKDSHFLTSPPSGGKKIIFGTVALIVVLMLGLASLALGLVLAHEVKEPSATANNALANRGTKLDSDAYYVNFNPTTLVTIASWSSTVAPLLTVCAMTLVSFPIAKQLKEHSQIADRDLPTPYQFGMLLESMTGGITPLLNLVAYRSWPNKEKMASSVRNALILLTLFTVLGYTIAAVDTWLHLVIEAINIEIVEPQSPIMALGRGLPDGPCSTQSSASFNAGDCIISDQGKVFLVGANEAARVMSNTSSTNAVYDVLINNMRMAYLGPADNPDGLDYRAESLAMHTTCTQIGRQCGLHAETGELEPFTCTDAFYGNLAVPSINGEENDVVTGLPFRSAGIVFFRNAALTDLANASSESGNETYLMRPSNPHHIGVWAHVELPATGDQTADGNVVVPSQGGTSWLLNCTATAYQISYDFLNGSVQHATAEMANGSVGTILNAGNYYGFGKVALETAAYSASQYNDTEQMADSWAQAYSRAALALSSGIMSGRADLEEQQRSTKLVARVPKAPLYALVGLNSLYAAVGVLLAIIALRSHPKDSNGIRERLSTSGLVAAHFEGERAEQAVGKKREMFGEYEGVSTGRVGIEQSKHGGYAFRLRQGIQGRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BV08</accession>
    <name>A0A0D2BV08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_07836</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235265.1">
        <property type="nucleotide sequence ID" value="XM_016382163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BV08"/>
    <dbReference type="STRING" id="91928.A0A0D2BV08"/>
    <dbReference type="GeneID" id="27334919"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07836"/>
    <dbReference type="HOGENOM" id="CLU_119720_1_0_1"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW15049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="104" mass="12374" checksum="1288B69FC9C49407" modified="2015-04-29" version="1">MPQDLPPTGGYEAVQYRRNLPTRGFRPVWYLVGVGLIMGYGWRQLFKGQRERIELSREKMWARIHLTPVMQAEEDRDQVRRYYADLAREKELLGSQSKPYNSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWS8</accession>
    <name>A0A0D2BWS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PV08_05809</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235975.1">
        <property type="nucleotide sequence ID" value="XM_016380148.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BWS8"/>
    <dbReference type="GeneID" id="27332892"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05809"/>
    <dbReference type="HOGENOM" id="CLU_000395_5_0_1"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="18">
        <location>
            <begin position="65"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="222"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="16">
        <location>
            <begin position="700"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="19">
        <location>
            <begin position="1530"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="20">
        <location>
            <begin position="1873"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1224"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KIW15759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="2293" mass="255780" checksum="62471B0BBDE1D825" modified="2015-04-29" version="1">MAPTTNGVNGVNGASARRSTLVNSKPSEWQAKHKIAPHFIGGNRLEKAPPSKVKDFVQAQDGHSVITSVLIANNGIAAVKEIRSVRKWAYETFGDERAIQFTVMATPEDLQANADYIRMADQYVEVPGGTNNNNYANVELIVDVAERMNVHAVWAGWGHASENPKLPESLAASPKKIIFIGPPGSAMRSLGDKISSTIVAQHARVPCIPWSGEGVDDVEIDSEGIVTVRDDIYDKGCVHSPEEGLEAAKKIGFPVMVKASEGGGGKGIRKVENEAEFTSLYNAAASEIPGSPIFIMKLAGNARHLEVQLLADQYGNNISLFGRDCSVQRRHQKIIEEAPVTIANPDTFHSMEEAAVRLGELVGYVSAGTVEYLYSHADDKFYFLELNPRLQVEHPTTEMVSGVNLPAAQLQIAMGIPLHRIRDIRLLYGVDPHTATEIDFHFKDPASLKTQRRPRPKGHTTACRITSEDPGEGFKPSSGTMHDLNFRSSSNVWGYFSVSSASSIHSFSDSQFGHIFAYGENRQASRKHMVVALKELSIRGDFRTTIEYLIKLLETPAFEDNTITTGWLDQLISNKLTAERPDPMLAVLAGALTKAHLASEACIAEYRKGLEKGQVPSKDVLKTVFPIEFIYEGQRYKFTATRASLDSYHIFINGSKCLVGVRTLADGGLLMLVAGRSHSLYWKEEATAIRLSVDSKTCLLEQENDPTQLRTPSPGKLVKYTVDNGEHVKAGQAFAEVEVMKMYMPLIAQEDGVVQFLKQPGATLEAGDILGILALDDPSRVKTAETFTGKLPDLGPPQVVGNKPPQRFALLLGILQNILLGFDNQVIMASTLKELISVLRDPELPYGEWSARSSALHSRTPQRLDAQLSQIVERAHARHAEFPAKQLQKAINRFIEENMSKTDGLTLHTTLAPLEDVISRYSEGLKVHEFSVFTGLLDQYYDVEKLFASGSHRDEDVILKLREENKDDILSVCYTVLSHTRVSAKNNLIVSILEMYRPNQPNVGNVGKYFKASLRRLTELESRATAKVALKARELLIQCAMPSLEERVSQMEHILKSSVVESKYGETGWEHREPDLEILKEVVDSRYTVFDVIPLFFAHHDPWVGLAALEVYIRRAYRAYTVREVEYHNDVEPPFFLSWDFVLRKVGQAEFGLPLASSYPSGQATPSQQGSPFKRITSVSDLSYLNKLQSDDEPTRKGVIAPCHYLDEVDECLARALEVFPKGTKEKRPSQQHLMPTLDSVRKPQPKQPEPVDDDLTNVCNIAIRDTEDLPDDEILGRVQSLVAENKAELLARNVRRVTFICGHKDGSYPGYFTFRGANYEEDVTIRHNEPALAFQLELGRLSKFKIKPVFTQNRNIHIYEAIGKGEDRDKVVDKRYFVRAVVRPGRLKDEIPTAEYLITETDRLVNDICDALEIIGNNNSDLNHIFINFSPVFNLQPKDVEERIAGFLERSARRFLRLRITGAEIRILCTDPETGLPYPLRVFITNTSGYVVNVESYVEKKSRSGEWVFESIGGTTKVGSMHLRSVSTPYASKEWLQPKRYKAHLMGTQYVYDFPELFRQAVANSWAKAIAKHSPMADSRPEVGHCLDYNELILDDSDNTTEVSREPGTNNCGMVAWVVTAKTPEYPRGRKFVIIANDITFQIGSFGPNEDKFFNKCTEYARKLGIPRIYLSANSGARIGMADELIPHFSVAWNDEGKPEAGFKYLYLTPEKRKQLTHKEVITEEIQEDGETRHKIVTIVGSKDGLGVECLRGSGLIAGATSKAYEDIFTITLVTCRSVGIGAYLVRLGQRAIQIEGQPIILTGAPALNKVLGKEVYTSNLQLGGTQIMYRNGVSHMTASDDFQGVEKIVEWMSFIPDKKGQPVPVGIAADTWDRDISFYPPRGPYDVRHLIAGKADDEGFLSGLFDKDSFQEALGGWAKTVVVGRARLGGIPMGVIAVETRTVENVIPADPANADSMEQVVQEAGGVWFPNSAFKTAQALKDFNYGEQLPVMILANWRGFSGGQRDMFNEVLKYGSYIVDALVKYEQPVFVYIPPFGELRGGSWVVVDPTINPEQMEMYADEESRGGVLEPEGIVGIKYRREKQLETMARLDPTYGQLKAQSLAKDLTSEQLNEIKVKMAEREQLLGPIYQQIALQFADLHDRAGRMEAKGTIRMPLKWQNARRFFYWRLRRRLSEEVLLKKLNASLAAGGVPTTPNALAQKESNLAMLRNWSGLLDVEFDKDDRKVAEWYESHRKEVYAKIDAVKSEAVSKKVSELLMGNKEGGLKGVREVLSLVPTSEREQLVKYLTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BY05</accession>
    <name>A0A0D2BY05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236400.1">
        <property type="nucleotide sequence ID" value="XM_016380573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BY05"/>
    <dbReference type="STRING" id="91928.A0A0D2BY05"/>
    <dbReference type="GeneID" id="27333318"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06235"/>
    <dbReference type="HOGENOM" id="CLU_046346_0_0_1"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="239" mass="27590" checksum="B3191130A78629A2" modified="2015-04-29" version="1">MKLNVSYPANGSQKLIEVEDERKLRVFMDKRMGNEVPADSLGDEWKGYIVRITGGNDKQGFPMKQGVMLPTRVRLLLSEGHSCYRPRRTGERKRKSVRGCIVAQDLSVLALSIVKQGEGEIPGLTDVVNPKRLGPKRATKIRRFFGLSKQDDVRKFVIRREVIPKKEGAKPYTKAPKIQRLVTPQRMQHKRHRIALKRRRAEASKDAANEYAQLLAKRVHEEREKRTELRKRRASSMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C5D3</accession>
    <name>A0A0D2C5D3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239020.1">
        <property type="nucleotide sequence ID" value="XM_016377450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C5D3"/>
    <dbReference type="GeneID" id="27330176"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03093"/>
    <dbReference type="HOGENOM" id="CLU_082161_0_0_1"/>
    <dbReference type="OrthoDB" id="3890746at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="295" mass="31024" checksum="52BFEA372CB3F18B" modified="2015-04-29" version="1">MATVSSSRSGSASSDRRPGSGSGSSTTKHLEPPTPYETTAFMTNASPLLTSSLHSRNSASSIQESAYLAKAQVLQWSRLGLAVLVIASATAALGCAGHVLDRYNETAGVGKPYHLPQLWPANVDVRPTLAVLIPAAIVITVNLGYVVFSLIPTPYSRTLMYNFVFLASSLAGLVLCLFAIPFSTTLTDPSAHHSRESLHSWTCKFSDGAASFTSNAKALQIPVYLSAGVPVPAGFKRLCKESQVGVGLMATVMVLEAVSCAVAGAGILLEKRIAKARKARYAAAAGHDEKRETLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6F2</accession>
    <name>A0A0D2C6F2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03441</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239365.1">
        <property type="nucleotide sequence ID" value="XM_016377795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6F2"/>
    <dbReference type="STRING" id="91928.A0A0D2C6F2"/>
    <dbReference type="GeneID" id="27330524"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03441"/>
    <dbReference type="HOGENOM" id="CLU_023194_7_2_1"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="146"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="388" mass="43089" checksum="D0187E8FA7E87F2B" modified="2015-04-29" version="1">MVYTVRWGILATGWIAEKFAGDLLKDPSTRNTRDVAHVVAAVASSSGKDRAERFCRDLGISEACAIYGSYRELVNDTNVDIVYVASPHSHHFQHTMLALEGGKHVVCEKPLTVNAAQAKILYKTARENNLFLLDAVWTRFFPLSIQIRESIQKGEIGEVLRVIADTSFGIHPDIALKETPRKLTYELAGGALLEIGIYSLTWVFQTLYHTLPRDQRKRPSSILSYMNKYEPTGVDQTTTLLISFPTSTPSNLPNSSSHGVAMTAFAVATDPDQKNSAGPAIRIQGTRGEIQVYGPAFQPTRYKVIPAKKGDLATTIRDVELPFPANGHGMFYEADEAARCIRDGKLESETMPWDESILVMEVMDEVRKQGELKYPDSIESDVVQHSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6J0</accession>
    <name>A0A0D2C6J0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239410.1">
        <property type="nucleotide sequence ID" value="XM_016377840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6J0"/>
    <dbReference type="GeneID" id="27330571"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03488"/>
    <dbReference type="HOGENOM" id="CLU_096551_0_0_1"/>
    <dbReference type="OrthoDB" id="4117640at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28382" checksum="C8FEE7D435630B3C" modified="2015-04-29" version="1">MSLAICLQHQVESEEKAERLRGLLDDVARVTFLDEPDNRAYCWFRKSSHSTLEGPWIAGFELYDNEAALTTVHRSSTEYQAMRKASAEEQLWGKVYPEIIFLEPLDDSGFVNKDSRSSLFFKECRSTFVVLTRFEVEDADKELLYQTLSNLGGSLRLEHDVVSYLPLVRRDGKSLVVTVFEQYGSEEAYNSLTGNLEPLKSALESPKWKVDITTWSDGIGHIRGTESSKPKVLQSEAPAVFFVATPASSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6S1</accession>
    <name>A0A0D2C6S1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239495.1">
        <property type="nucleotide sequence ID" value="XM_016377925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6S1"/>
    <dbReference type="STRING" id="91928.A0A0D2C6S1"/>
    <dbReference type="GeneID" id="27330656"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03573"/>
    <dbReference type="HOGENOM" id="CLU_011226_15_0_1"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03189">
        <property type="entry name" value="GST_C_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="127"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29453" checksum="727520689A9BABED" modified="2015-04-29" version="1">MTSVSPDAGETPKVVLHWLEVSRSHRILWFFEEIGLSYELKTYKRTTEGLAPQELKKVDPLGKSPVVEIFPPDSTKPIVLAESAAIVEYFCDYYGRWLVPPRYPDGKDGQIGGETEAWLRYRRFMHYAEGSIMPLMLLGVIVNRIRSSPVPFFIKPIVTGVANKIEASFLQRNFKTHYDFLEHQLATAPDGGNFLCGKDLTAADIMMSFPLEAGESRSGLTKEQYPRVWAYLDKLHDREAYKRAVASIVEREGEFKTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8K6</accession>
    <name>A0A0D2C8K6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00454</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240095.1">
        <property type="nucleotide sequence ID" value="XM_016374819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C8K6"/>
    <dbReference type="STRING" id="91928.A0A0D2C8K6"/>
    <dbReference type="GeneID" id="27327537"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00454"/>
    <dbReference type="HOGENOM" id="CLU_030903_0_1_1"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="51"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="377" mass="40649" checksum="55C71AD7422B0845" modified="2015-04-29" version="1">MPSIDTPVELNEDVRVLGYDPLIPPALLQSEVPATQASIETVSRGRKECKEIIHQRDDRLLVMVGPCSIHDPATALEYAGRLKQLAEKLSPDLCIIMRAYLEKPRTTVGWKGLINDPDIDESYKINKGLRVSRQLYADLTAMGVPIASEMLDTISPQFLADLISLGAIGARTTESQLHRELASGLSFPIGFKNGTDGSLSVAIDAVGAAAASHHFMGVTKQGLAAITRTSGNEDGFVILRGGSKGTNYDAESVKAAREALKKKGHPQVMMIDCSHGNSKKDHRNQPVVAQAIGDQLRQGEDAIVAVMIESNINEGNQKVPPEGGLASLQKGISITDACINWDTTVEVLEQLADAVRTRRQVRAKQQQNGTNGVNGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C9W9</accession>
    <name>A0A0D2C9W9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CTP:phosphocholine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylcholine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_00939</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240580.1">
        <property type="nucleotide sequence ID" value="XM_016375304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C9W9"/>
    <dbReference type="STRING" id="91928.A0A0D2C9W9"/>
    <dbReference type="GeneID" id="27328022"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00939"/>
    <dbReference type="HOGENOM" id="CLU_034585_5_1_1"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="157"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="433"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW20364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="504" mass="55006" checksum="6D560C5200F11CDA" modified="2015-04-29" version="1">MSSPSSSSSAKRKRSTAPSAAADLQQPLSRDASGEELADAPSHSTRTRKHGTSSSIDDNVPPSKRARTRSSANSVEHNGADEQDPSDPSSTAEGTDQETEKSSSNGDRTQKVPSSVTKAVVNGQEQPMASVPKAGLRDPVGGYKTNPPPEGRAVRVYADGVFDLFHLGHMRQLEQAKTAFPNTYLIVGVTGDAETHKRKGLTVLTGAERAETVRHCRWVDEVIPNCPWIVTPEFLEKHQIDYVAHDDEPYGADEGDDIYAPIKKEGKFLVTQRTEGVSTTGIITKIVRDYEKYIARQLKRGTSRQELNISWLKKNELELKRHVQELRDNIKTNWTTAGGEIGRDLRQLWQNASSRPASPAPFTRSLSAEGSVLKSPTAASAVEHLKHLEVPGSAERRSDSPGRFSRSDDFAAGYSLGLIGGVKSWMMRGRRALRDSQPPSPDGSEDDEARSPLSATVSNGGEMISGLKTPPFFGRGRKGKSSSEPDFEQGETEDHERDAMDVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAF5</accession>
    <name>A0A0D2CAF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-exchange factor SEC12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_01114</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat SEC12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240755.1">
        <property type="nucleotide sequence ID" value="XM_016375479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CAF5"/>
    <dbReference type="STRING" id="91928.A0A0D2CAF5"/>
    <dbReference type="GeneID" id="27328197"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01114"/>
    <dbReference type="HOGENOM" id="CLU_021000_0_0_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <keyword evidence="2 10" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW20539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="646" mass="70001" checksum="1EDA1FB576B7189E" modified="2015-04-29" version="1">MAPNVVSSQVKLSYPLYAADFDPYNPDFLLVGGGGGSSSTGVPNKISLIDTTQREQLAEVVDIELAKDEDSVTSLAVSDSSSSSLVAFAGINSSVADQNAGKNEHLRSFRIGLPAKKRRADGTAVEKTEKPTQGSQALGRTALFKSATGSKNETYQRVLRFSPAQQPGKSRIAAIASGLAPENEIIVFKPAPKPTPKDEVSRISLGNSEAGDLDLCSDNDEEGGYILAYCTDDEVFVQKLPVSSSQKNSPASLYRTTESTTSLPPSKRPRFRAIRFLTPHHLLLLQNRPGRSGADLLVLRVSQDFSQSRVTLRKRLDKSTKAAVGLDVCTLSPSEQGDQQTVIAVAGQSGDASSIELLTIDYSGQSGLLGTFRSYTLLRNIHSGPLTRLVFSRFQGPSLPVTKDTPPQSIRLASVGVDMMVKVQYLPLRPFPTLYTKTPRYVLIPPGRSETMQTTFSVFFALVVVGVVAVLMQAFCEIRGAVPPVLGASDWLSPRMREVIARPYLFADGLPSIKPSDIPVAAHSATERVKTAAEGVQSEISHVVSDLEKTLEDFVRENSRLDTPKAIVVRDGAEAGELSTEVLEHDANLVRDETLKKWEELSEHQKRSWKRKLIDTGHWAEKQGEGVLKGILFSELAGVVGNMVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCN1</accession>
    <name>A0A0D2CCN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241475.1">
        <property type="nucleotide sequence ID" value="XM_016376199.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2CCN1"/>
    <dbReference type="GeneID" id="27328922"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01839"/>
    <dbReference type="HOGENOM" id="CLU_000592_0_0_1"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1121"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="2">
        <location>
            <begin position="1241"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1648"/>
            <end position="2191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1887"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2004"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2057"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2614"/>
            <end position="2686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2809"/>
            <end position="2985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1904"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2626"/>
            <end position="2645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2824"/>
            <end position="2834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2850"/>
            <end position="2864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2869"/>
            <end position="2880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2881"/>
            <end position="2890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2911"/>
            <end position="2921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2939"/>
            <end position="2960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2973"/>
            <end position="2985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW21259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="2985" mass="337744" checksum="6F62A5003B28E4DE" modified="2015-04-29" version="1">MPLLNATSIAAVLILLYLSSFLLLAILRIATGVSIQRIGYFSLRHISYTPREGLRIDLRGLGLSPHRPTFAQPTWISLVFEDLKVTIDPAVYESSPRRHDTRGVDVQHAADDKKKEIGSSRPGGRSKLWKKLTNIKEWLKRIHRQIHILRMFDISFINTSAEVVGVGYVQISNFHMAVYTRRRLLDRGRLFRHKKEPLGTQKPAEWVFAVRSVLLGSGGHDPIEILDNMTINVHGLLYKEREGLRDTSIAIKAGRLYAPVDEILLFRQRAQKIQTAAHIFHPSSPVEGISLEDLVEELDQPGSREASIVQTVADSKEFFSSVLRSVQEIQIALSFVRISKEIVSLRQANLPLIANMVIHEIGVDLHRLDQNSPSHRTYFSKDDVAHQALVAAISISVSLDEDDYQTNKIMYIPMATTTIRTTLPSKTMNFTHENDVAERNANILFANLVVTSPSLDLVPSHLMKLLAVAQSKAQPTHRSPQNRHRLISRLLPKASIKFSIHEPVVRFILPLTNSASGEYNMIISSITSMSLDVESSHSAGGELLYSLGSNFRVMSHQLYYQASTGVKHNIIVMEAMEIKAQVSASTEIAVSISGNLRTFSVLMVREEVSKAIYNIVRHFKRRVPRDKSNAARTPSASFLRKLPSWIIEASFEGSGFSLETAGVDSSVSSQTRGVALELESWTSHYTSSLLDMARKSVSRRKVSATARLEDPLSSGRHLSPPTSPPRRRHDDPTDGRRLTLHVKGLDGYIIESLDSWEPKPFTSIPRFEVAFSTSRDQQGPLFHINSSIRAIYLEFSLYRLYSIGVAGSIVKDTFLGPAAPPADVHAHPPIGTPSANNANHVPVPLGQELSVFDMKAHYIQIKGHMPADPPMMLQVYQVAGGRHRWSAPFLRADLVRLHAEAPYMRNVYARIVTTTNLRLDLRHAKRKTQHGMSEEHTIDVSTEFIRLAVPHGLQMYKIFDNFINTGKAIAQLGHRFKTRTNEYILKKEPVGPKKVPRVSLRSKALCFQLEDDPFEWKLGVIYHAGRIEQKQRLAREDAYRLKVKRLQEDRRPRSTSRFRGNSSRPNSPGNMERNPRRSRSADLTPRRRSASRGRRRGSTRIRYDREGACTLSSSAKIQAEEAWQRLLEHNSRSWKRRVDWMMKLQNTTMRSIRQMFAGADEPPHDSGEHEAILGVPDRPGLMTAIISDVHLLVDKPSFPFSELPKFLHDIGKGMPYDTQYALLVPLGLSLDMGEARVMLRDYPLNLLHVPAIRPGQPAHLPSWSLRTDFVIAEEYRDEESIRHVKVEVVPKGQHFQSGEEIPGFYIDVRRTVSPVKTFSKPVVDINTSLPTTISWGTSYQPVIQDMMMTIEGFTKPEIDPSERVGFWDKIRMSFHSRLVVNWKGDGDVQLRLKGSRDPYVVTGYGAGFVMCWRNDVQWSIHSSDDPREFMTVRSGEYILAIPDYSHEARNTPEQRATKETDSMSISSSQKNAAMFKKVIMKVSGNVQWTAGLVFERALDDGGRSSDFSPHYDVILKNPAMMHGVDMTNYDAFRGFRSQHIHLSIAIAAPFDRDWLSADASPSESYNSVHLSPRFFSHFFNWWSLFSGVMSLPVRQGPLWRGVENSSKKFGRHLATIKYGLLLSPLFIAHVYKHKDAEDYQEDIVSATGLKIKIDSFMLDLHQRREYFDTLSKGKSEQMRTSAMKINKAELDFMRADLRAVAASIAGTTAEDLQKATDETLSSLQEVSHNIDMSQFTIPDHDFTWIDMDDFVELDWVLPAESNPETKILPLAFTPRFTYFRETDHGDGGIQGDESRTSPFGEEDTHFCVMSRHNDPRKVQMNLVEGRLHDLEDKLQAHMRIMSDHELKVIRDGDHDQAVMEKQKTLVAQRKELDSKRKFLQHGLQHLMRHGNPGEQPESDKSSSHRNGSTATSATEQLDAQNNGSPHVDMDALYSSAPDEFASDFNNRFIIHNAQLKWHNSLRNIILRYTHQVSQRRGFVYYMSRRAVKFLLDIVDEQAKAKELRRKQEKKGVPPVPATPNVISPTDEKDEDSVVQDRINQLLSDAIRFVHVGDADRDKSTKAESTDAASERRPSTEDLGDKIAENFQAMNSYHLRLIAPQIQLQSEKNEKAVVLIATKGMQLKVVSIMDKARISDDVSGLVQRRFALDMDGAQFFVATQKTLAQYLHLYSGNRYGNAPGSSWPPWVSLEAMFDFHLEPFGFQRVIQKTSASLRYEKYNPLRLKYNEEVESDGSGEGKNPSRREDRIDHVWVDFPRVRARCDSQQYYTMYIIVLDLLLYSEPLEKTRSERLEKIMLASDFSDLRGAPEIAQNLQERIRQLEEIKLHFQINAKYLDKRGWQDRINLEKDLTSCEDELFFIMKAINTSQQRYDDRKSSETSGLLRWYLSASEIVWHLMLDNDQPLAEFQLGNAAYERVDNNDGSNHNALGVEHIRGWNLLANALYPEIIGPYYEPGERHPSTRQTQKMVEVQWYMLEAIAGIPVLEQFYVTVHPLKVQLERELGKKLFEYIFPGVGSNAFESNNFSPLMVQNMAPLDEGNDQELEDAQNALMSETDLRGPSMEQKRDASPGEIARRLKPTYRLTYKEKATPSTTQPKYKGLGIGSEHHKFFKHFNASNPRAVLREPTRKGSSGSLRSNKKNNASSGSLVTLGHTEEKKLNMLHRTTSRERGALIKKSRDKKEKPSDDLSQMMSRASNYMTLAHVKLNTFIICLSYKGKGDRNIEDLHDFVFRMPTLEYRNKTWSNLDLALRLKKDVIRALISHTGAIIGNKFSHHKPNKKQVERLKEIAMNSTIPNSDINLQLSNTSENTSLYSFSQDSKDDDFESSGISFQSPTTRENGHGKMPAFGGAVPSPLLRSGSWSSTSLSKGPVLPAPRSIPPPTTPSSTGSTDPPLFRPSTATSQAQSSGGGQRHSLKDTIGRHFSSESSKGRVHFGPLSLGKSESHKEGLSTASHGRDGQHDDGAESDPEGHRRKGVLLLGKKVLNRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y6K4</accession>
    <name>A0A0D1Y6K4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230707.1">
        <property type="nucleotide sequence ID" value="XM_016385763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y6K4"/>
    <dbReference type="GeneID" id="27338538"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11455"/>
    <dbReference type="HOGENOM" id="CLU_049201_0_0_1"/>
    <dbReference type="OrthoDB" id="4117455at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="361" mass="40231" checksum="44A99D3150E5143F" modified="2015-04-29" version="1">MEDNSPPRPREDRGPRIPPAKLSDIKPNPTIAIFYRTGKGSPLQLVDGNFSRDAAMIFCDRIRHDFMDDNSRKSFIVTGIDLTGLKETVAWINQCVSEQSIVKYRELEADTPELLSRYANVIIAATYLGVPARDLAEGLTKRMQGIARKVLMSWKEVEWFYTSPALNNCKDSLREVAAASVFWAWWNSVLNEEDTPEELDTLEELRSRIPKLDGDLHDWCERNEAEVKKKWEEKKKARKDPNVSNDPEDFKGWDTIGIGKTPAGSGEGGGFDTGDIFEDNPGSAAPGAWDVPSAGPENGEFGFDSGISLNSSANIKKENIFDPGHGQAHENGNAKTDNWDVESTGGREWADEVIEHQASTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8A4</accession>
    <name>A0A0D1Y8A4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231432.1">
        <property type="nucleotide sequence ID" value="XM_016384830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y8A4"/>
    <dbReference type="STRING" id="91928.A0A0D1Y8A4"/>
    <dbReference type="GeneID" id="27337599"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10516"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="53553" checksum="EDA346EEBF0BE095" modified="2015-04-29" version="1">MEDSSKVEPTNIEVARPRLEYTEEEAKRVIRKLDWHILPLCFVLYTFSVLDRGNLGNAKLAGLYEDLDLTGEKYDWLGTMFYIAYIVFQFTSVGWKLFKPHMWVSFVVLAWGTISTLQALCTSWSGLMICRFLLGLTETMFGPGIPLYFSFFWPRRFVGLRFGIFLSGAALGNAYSGALAYGISHIHSSVAPWKILFIIEGAPTALLAIVCWLYLPDSPREARFLTERERDIAVHLAGDSQDQVKEPGKRGIHLQSLMAAFADYRNWMFALSNFSTNVSFASLPLFLPTIISEFGTFNKLTSNGLSAPPYLLSFFLIVGVAFFSDRLRIRGPFAASFATVAAIGYLVLALTTSIAARYVSCFLIVTSFVTVSTVLVWNANTNENESKRAGGVWIIQCVGQCGTILGTHSFPAQQQPYYRRGMWTGFAFSLFSAVLCTTLSILLHRENKRRDHVYGKVENVDGESDNLPPEARFRYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8W6</accession>
    <name>A0A0D1Y8W6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231637.1">
        <property type="nucleotide sequence ID" value="XM_016385035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y8W6"/>
    <dbReference type="STRING" id="91928.A0A0D1Y8W6"/>
    <dbReference type="ESTHER" id="9euro-a0a0d1y8w6">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="27337804"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10721"/>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112322" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="33"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="571" mass="61799" checksum="E9CB4589CFDD1D20" modified="2015-04-29" version="1">MLSSSPLRFLGLLWVSLLASSAYGGLIGRQSDVPTVKVKNGSYYGFHNPSYNQDLFLGMPFAQPPVGELRFNLPKSLNTTWDSPKNATQYGYQCYGYGSDQWVLGNIVSEDCLTLNVVRPSGIGQNASLPVGVWIHGGGFFEGGGRDPRYNLSKIIQASVDMGKPFIGVSINYRLQAFGYLFGTAVLKEGVTNLGFRDQRLALHWVQENIAAFGGDPAQVTIWGESAGGNSVGTQLIAYGGRDDKLFRAGIMESGCPVPFAPAINASAWDKYYNNITKATNCSGAPDTLACLRKVPIQRLSDVLNSSVTATVPGWGGHIDGDFIEGSASQQLLDGKFVKVPILQGANFDEGTSFGGKGINTTQQFLAYVSSTGPNATTAQTVAALYPDIPGIGIPATLDGRPTGPWALLGKQYKRASAYGGDLSMHAPRRFTSMCWAAQNVSGYSYHFNVVPNGVPPQIGATHFQEVAFVFDNTAGQGYNNSVAKDPFANMPRSYDRLANVMSRMWASFIADLDPNVNNATAVHWPKYNLTTPQNIVFDTNHTNLMYVEDDYYRAEGIAFISENFVGVYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YBG6</accession>
    <name>A0A0D1YBG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09553</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232492.1">
        <property type="nucleotide sequence ID" value="XM_016383869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YBG6"/>
    <dbReference type="GeneID" id="27336636"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09553"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="70"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="518" mass="58158" checksum="4B40D3CA21108F66" modified="2015-04-29" version="1">MDPQKELATDAKDVVTITPARDEMLLQQGDLKLAAGYDDDIGLRIIHETGNVSIDPTVTRRALRKIDTWVLPLLALTTMLQFLDKSTLSYAAIFGLIEDTPFAAHLLQKFAAAKCLAASVYVVSIDALINYNQHILITLRNRFFWGVILFMHVVCDSWAKLMAVRFFLGMAESIVTPAFILISGAWYARQDQPLRMGFWFSFNGIAQILGGLLSYGLGHIHVGIASWKWMFLVTGAISVLWAIVLWFMLPDNQGTAWFLNDEEKYASIEMVRQNHTGIHNTKFRREQLVEALCDLKTWAFFWMALIWNIPNAMVTFGSLVIKNFGYGVLETTLLGMPSGALEFILMLIITWVCLKVANTRTWCMITALTIALVGAVIVFAAPYHNKAALLGGFYIMFAFPTGYILLLSMISANTAGHTKKVVTNSLAMIGYSTGNIIGPQFFKPSQQPRYGLGIGACMVSFAVLIVMLISLRIFLVFQNKRRESTRLQLSEQAEDHTMTEFDFKNLTDKQNPLFVYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDN5</accession>
    <name>A0A0D1YDN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_08318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233347.1">
        <property type="nucleotide sequence ID" value="XM_016382644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDN5"/>
    <dbReference type="STRING" id="91928.A0A0D1YDN5"/>
    <dbReference type="GeneID" id="27335401"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08318"/>
    <dbReference type="HOGENOM" id="CLU_012260_0_0_1"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF9">
        <property type="entry name" value="PAS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="368"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="699"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="805"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="860"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="957"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="818"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="864"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="917"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="965"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW13131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="984" mass="108992" checksum="D82D86F5F572A3FF" modified="2015-04-29" version="1">MDLERIKQNLRIRAGRAKKPRKGAAERTSVAPAEASKAEQPVMKANDTVQSPRVSSKQASPPSKVEMPSRARGVFNPLPAVESANISKPRPGLPHATTGSSIKLTLPEHLPRYGRSGIEKPQRGPPSKGQPIRRTLSDSDTKTGLGSDSSDVLDFDLRPPPPRLKPPSVESLSELLFSARHLNVLVYKPQYLAAFTAFIQRYRPQYHDVLLGYLESQKAIKAVEYANAVAQSISSEATTAIQPMQAASLDKVFEEWNKSCFHTLIDTALPMYITYNLVNVVTECLINEITGRQTPLTRDLIGGLSEVFCLTDPSQQDNPIIYASEEFFRLTGYGVDDVIGHNCRFLQGVKTNRASVSRLRGHVERGEETCETLLNYRRDGRAFVNLLMTAPLHDDQGNVKYNIGAQVDVTGLIERGKGLESFGSLLINRGLGRPAHKVDGNASHVVEQAPKKAHALGKLRELSEMFDLEESAAVKSHGRSSPRSTDDDEQSMVSRTRRIYGDYSSSEDRDEESGDDEDTTWKLAESGRSGLSGKLPGVYDSYMLIRAAPSLRIVFVSPRLRRRFGNIVQHPFLAHIGASPATLAGLRDSFGTGTPVSAKVNFMVTAGERRDGITVPVGSKPGNLGHHRVSWISATPLIGSDGKVGVWMIVVVERTRIPKDLKDNGVRGSTTTIQPLTTNRLEMLDIQTRDMPDNVQQILPQRSRRRVQQIEDMPIKPKRLVEETNGTTSVQQQQQQQQQQQQPQQQQPIQVPYQKLRIDDDELQAANNTAMEHVEVVTPPRPENEQNVADVETVKIKNCIAVEGGRPEPEFAPIPVSSPETEAHQPQQVAIQPRNEPKPSTLNMSEVDNALLRSLPAADKLDSPVSQPHSPTDSGFQEVPKHSHYSSEDDDTPRRPQRPGFLEFTPTQSRPGTSGHDGGKSHGKHYMDYIRHPGSRPSSDYNLVMSSGMLSSMYHEYHDIAEKDEQGDEDEEDEECARTPYSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YEY7</accession>
    <name>A0A0D1YEY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233842.1">
        <property type="nucleotide sequence ID" value="XM_016383139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YEY7"/>
    <dbReference type="GeneID" id="27335900"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08817"/>
    <dbReference type="HOGENOM" id="CLU_107661_0_0_1"/>
    <dbReference type="OrthoDB" id="2555434at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646">
        <property type="entry name" value="YALI0F00814P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="33"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="137" mass="15403" checksum="D227B4B3C1D21F00" modified="2015-04-29" version="1">MFTSRHPEDQFRLRMHRARSVELSNDELVEIRAAQRTFEGAYIRTSLSQFSFALVVLKIFTSEFYSIGALFAVYGAGVLLVSAYRRQQGNKQFFDEVGDDGLGRKRFRTSGNVVVVLTALSVAAYITLLVLTLKLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YHA0</accession>
    <name>A0A0D1YHA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_07108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234542.1">
        <property type="nucleotide sequence ID" value="XM_016381440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YHA0"/>
    <dbReference type="GeneID" id="27334191"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07108"/>
    <dbReference type="HOGENOM" id="CLU_044233_0_0_1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW14326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="449" mass="50347" checksum="3FDD00D34DF485AF" modified="2015-04-29" version="1">MTVGPFDLRKRRSRCVQCSSSHLKCSGEVPCGNCTRRGKVCSPPTQDNTIKVTTKHAKPPNSPAPQQQVIWALARPVAVDKQSLYVVEFFDKFLERNSFTGRPQSSFPAVRSVLEGNQSLLNVISAIGALQVSRWRPATCTRRDALVNYRDAVTALQSEIECAAGSRHAIVGLSWSTLFLGLFELMYESTGDGWIRHMIYGTSRLLQLLTPEGCSWGPGREFYLEARIFEVARSMLFVEESFLTTPPWKSLTLTVWSGTYAKDWTPLESLLDIMITVADLCIRAMRFILPREIDGACEVDVDQLRAFAEQGAALKTELTAWSNTAREWYAEHAADGHNFLSAVYYSAISIYHSGIYDYSDIWRHAEVTTPSLPSSDIQQHVRTILHLSTLALHHTNLSSIVFLLPLRIAGARAKLPEQRAQIRKLLITITNPFRAAKAIISDLEEVWTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YHM8</accession>
    <name>A0A0D1YHM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum chaperone BiP</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_07209</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234642.1">
        <property type="nucleotide sequence ID" value="XM_016381540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YHM8"/>
    <dbReference type="STRING" id="91928.A0A0D1YHM8"/>
    <dbReference type="GeneID" id="27334292"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07209"/>
    <dbReference type="HOGENOM" id="CLU_005965_7_0_1"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237091" description="Endoplasmic reticulum chaperone BiP" evidence="16">
        <location>
            <begin position="37"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="653"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW14426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="679" mass="74442" checksum="5B100D47C947907A" modified="2015-04-29" version="1">MARRGSGSSSAFQWTTIFYLLLIFVCPLALIGSVHAQDQTPLNESDANYGTVIGIDLGTTYSCVGVMQHGKVEIIVNDQGNRITPSYVAFTDDERLVGDAAKNQYAANPTRTIFDIKRLIGRKFQDKDIQRDIKHFPFKVVNKDDKPMVTVEVAGSPKTFTPEEISAMVLGKMKEVAEAYLGKKVTHAVVTVPAYFNDNQRQATKDAGTIAGLTVLRVVNEPTAAAIAYGLDKKGKESQIIVYDLGGGTFDVSLLSIEDGVFEVLATAGDTHLGGEDFDQRVIDYFVKLYNKKNDVDIRKDLKTMGKLKREVERAKRTLSSQMSTRIEIEAFHNGNDFSETLTRAKFEELNMDLFKKTLKPVEQVLKDAKVKKSDIDDIVLIGGSTRIPKVQSMIEEYFGGKKASKGINPDEAVAYGAAVQGGVLSGEAGTEDIVLMDVNPLTLGIETTGGVMTKLIPRNTVVPTKKSQIFSTAADNQPVVLIQVYEGERSLTKDNNLLGKFELTGIPPAPRGVPQIEVSFELDANGILKVSAGDKGTGKSESITITNDKGRLSQEEIDRMVQEAEQFAEEDKLVREKIEARNKLENYAVSLKNQANDDEGLGGKIDDEEKETLLDAVKETQEWLIENADTAEKDDFDEQYEKLSQVAYPISSKLYGGGAGGMPDYGADDDDDLGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YHP1</accession>
    <name>A0A0D1YHP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_07219</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234652.1">
        <property type="nucleotide sequence ID" value="XM_016381550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YHP1"/>
    <dbReference type="STRING" id="91928.A0A0D1YHP1"/>
    <dbReference type="GeneID" id="27334302"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07219"/>
    <dbReference type="HOGENOM" id="CLU_026673_14_0_1"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="21"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW14436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="382" mass="40558" checksum="06501AD807700F12" modified="2015-04-29" version="1">MSASTVGKTITCKAAVAWDAGKDLTIEDIEVAPPKAHEVRIQIYYTGVCHTDAYTLSGKDPEGAFPIVLGHEGAGVVESVGEGVTNVKPGDTVVALYTPECKECKFCKSGKTNLCGKIRATQGRGVMPDGTSRFKCKGKDLLHFMGTSTFSQYTVVADISVVAITDKAPMDRTCLLGCGITTGYGAAVITAKVEKGSNIAVFGAGCVGLSVIQGAVKNEAGKIIVVDVNDKKEEWAQKFGATDFVNPTKLNGQTIQEKLIEMTDGGCDYTFDCTGNVGVMRAALEACHKGWGESIIIGVAPAGAEISTRPFQLVTGRVWRGCAFGGVKGRSQLPGLVADYMDGKLKVDEFITHRQPLSKINDAFHDMHAGDCIRCVVDMRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJF5</accession>
    <name>A0A0D1YJF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 15 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07878</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235307.1">
        <property type="nucleotide sequence ID" value="XM_016382205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJF5"/>
    <dbReference type="STRING" id="91928.A0A0D1YJF5"/>
    <dbReference type="GeneID" id="27334961"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07878"/>
    <dbReference type="HOGENOM" id="CLU_021102_2_1_1"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="8">
        <location>
            <begin position="381"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW15091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="533" mass="59259" checksum="52D85345CF46E549" modified="2015-04-29" version="1">MAADVQPIAQVKLPSRPSSLTPEQQYWRSFKSPLNIPSPTKHAITHVSQPEPHASTQTSPDFFTVTTGARIQLYSVKTRKLLKTITRFDDTAYSGEARYDGRVLAAADETGTIQVFDVSSRAILKTWKEQKQAVHNVRWSPRESTALMSCGDDRTVRLWDLPSESSVAVFRGHQDYVRTGSFLPGQSGNLLVSGSYDQTVRLWDPRTPDGAVMSFKHIASVEDVLCMPSGTTLLAAADNQVAVLDIVAGRPLHIIKNHQKTITCLRLASNNSRLVSGGLDGHMKVFETTGWNVVAGSKYPSPILSLEVVSSGTPREDKHVVVGMSTGQLSIKTRLSGEQKVKERERQKQMEALLAGKIDEYDKKQAKKRPRALERRLRGRDYAGDDADIIVEGNVRSRPKKIPAWERELHRGKYNMALDLAVSVGDRITVITALNTLRYRSALRAALEGRDETQLQPIMSWVWKNISNSTVVPLCVEVSMAIMDLYSKHLAESEPLARQVNKLREKVQDEVNRAQLAGMTRGMLELLTPITAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YLT0</accession>
    <name>A0A0D1YLT0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236197.1">
        <property type="nucleotide sequence ID" value="XM_016380370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YLT0"/>
    <dbReference type="GeneID" id="27333115"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06032"/>
    <dbReference type="HOGENOM" id="CLU_303839_0_0_1"/>
    <dbReference type="OrthoDB" id="4121287at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="947" mass="103876" checksum="66D04D28F7E4DA51" modified="2015-04-29" version="1">MRLRRTITIPTRYEDEDPRPPRARNGTRPAYPSLLRGQVIPFNPDHPPAQFPSLPLSSSRPSAHHLQPNIESIADPPSDLQEQPDSTVGDPVRDSKTKASVPRSSSSPTHSLVARSPDSSTDAIQEDLQVPVTATVYSDQLPRPNLDHSSALNTATVADGSVVSDTYRTEDAAMWNALPLSLQYHIFTSLARLHPTKHLVQLLGLTEEEFSQISRAASLREAHPASLADIWHSAWNGTAYVPGFTEDISIDAENFKEFADYMAFASSFEFAFQSEIRDAENYLCRRGMVCDLLGSWIPDPSEPQGSQYFVRLPSLATDPIPRSDSLLDSNDPPLPEVENEEVIAGSSSIHRSSPIDHTTVRKNISGKLIPRKGRVHSSAPIGSTSTRQRRYVASSLANPSKSARHPLANAALVPDSSSETIVDIGHSKSSEKLKSTALGQLSKEDVVPSTPDPSNLILKIQGKDGLARILKKKHRSTDNTLPLSAVQFEPAAQAPSVEAGHLDQENKSSLAKLDTSMSGFSKSLLMDRTIAESPVFDKQDSPTLESIQHAICPLQPESLPHKRKASRDARCTNSLKSPRTIGETPKTPPTSIVTHDINNEHLRHAEAKLSRQRCLSSSRNCRPADEPASTMPLASDDTLQLSSRASLTVAECLRSPSYSPISENEYLESYQALLRNPPRRLKISKAHWGAEAHTQLWENQSELSIGYTQDIPHDGNVSRAGLMSVVPLVKVKPDPRPSAAGAESAILEVPKKPKITLLCKNAKETSLSKVENSVRSGEETKAKTPSASSNSESDIVATPRGALKEDVEGEEATHSPAEQSQPKKTVPKRNTKVTSESICDERAQHIVRGSSTKSFVKTSEQNSNTTARETKESGSKRRGPGRPRGPRGPYRKTRERTAKEEQERQRMPQQAEQDESTPKKETIPQQHDHHGASMTNAEKKKKRQAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMC8</accession>
    <name>A0A0D1YMC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_06227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236392.1">
        <property type="nucleotide sequence ID" value="XM_016380565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMC8"/>
    <dbReference type="STRING" id="91928.A0A0D1YMC8"/>
    <dbReference type="GeneID" id="27333310"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06227"/>
    <dbReference type="HOGENOM" id="CLU_026014_1_0_1"/>
    <dbReference type="OrthoDB" id="2153847at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF1">
        <property type="entry name" value="CIRCUMSPOROZOITE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="543" mass="52971" checksum="7C6E9370876973CF" modified="2015-04-29" version="1">MKYEIAAAALMLGLSTASPVHQHNAREVPQEHSHNKFLDSVRASLLINNPLNIQDPVFGLLGDAAAAAGAGDVTDLACLQQETADTAFTNAKAAGDVGAMAAALVFRAIERNTGKVGLASAICTQTAANPEIAAITQHQDPASAGAADINKGITIALAQQLAGIGADPLLALESGTFAPGSLDDNTGKGNTCDTADDEPGCIFSQRLLVLDATPDEISSAVADITPTFTGTGGISATDIDFSGLSVAAATGVVSVETTATAVAAVATTDAVATGECTVAEATSTAAAAAASSSCTVITTTVAASNVGASTVTSVAAVATGGASGTNVQTFTGSLGGPPPPVISTAGAARPFSVNGNTFINIGAALQRSCAIQHNACADAANSGSLSGGVGQCETQEQECNAAGGVTKKLKARAAGDFGTCSDPTILFENGLDGRNTPAFIAADQTDFNHGSALNIAVIAGFICQRLGSPCNAPADVQASCTSASAAAVATTQNQAAADVFNSIIGASGGGGATTTVSSAAAVAVTSAAAASSSAIVMTITSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YP56</accession>
    <name>A0A0D1YP56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_04126</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237152.1">
        <property type="nucleotide sequence ID" value="XM_016378475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YP56"/>
    <dbReference type="STRING" id="91928.A0A0D1YP56"/>
    <dbReference type="GeneID" id="27331209"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04126"/>
    <dbReference type="HOGENOM" id="CLU_085752_1_1_1"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000003">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="112"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW16936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="175" mass="18012" checksum="E1849A3C3ADF906D" modified="2015-04-29" version="1">MAGIMETPGNEYTPSFAPFFGMASYDPELLTAGIASAMIFGCLGAAYGTAKAGIGIAGVGQYRPDLVMKSLIPVVMSGIIAVYALVIAVLIAGDMEPPPAKHYSLFTGFLHLASGLSVGLAGLAAGYAIGIVGDMGVRAYMQQSRIFVGMVLILIFGEVLGLYGLIVGLLLNSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YV36</accession>
    <name>A0A0D1YV36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose 1-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239362.1">
        <property type="nucleotide sequence ID" value="XM_016377792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YV36"/>
    <dbReference type="STRING" id="91928.A0A0D1YV36"/>
    <dbReference type="GeneID" id="27330521"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03438"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="26841" checksum="8D728126391D0B96" modified="2015-04-29" version="1">MAGILRNKVIAITGASQGIGRATALACARQGAGLVLHHLGTEQTTSDIEALQSELRAIDPSLRHTSFSGDVVLPETPANLVATAVGSFGRLDALINNAGICTFSAFHDVTQALLERHMSVNFTAAYMLTQAATKQMVAQGTGGSVVSIASITAVQGSSALTHYAPTKAAILGMTVSCASALGRHGIRFNSICPGTIETTMNKAHLDHNGQREVMAAKAALGRLGSPEDIAGAAVFFASDLSSYVTGQYLLVDGGASTHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVX7</accession>
    <name>A0A0D1YVX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239642.1">
        <property type="nucleotide sequence ID" value="XM_016378072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVX7"/>
    <dbReference type="STRING" id="91928.A0A0D1YVX7"/>
    <dbReference type="GeneID" id="27330804"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03721"/>
    <dbReference type="HOGENOM" id="CLU_059032_0_0_1"/>
    <dbReference type="OrthoDB" id="3884315at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="265" mass="30346" checksum="4F68F8955AEA5275" modified="2015-04-29" version="1">MSSSKAPIRSPSPTGSVQFAAPGAPTPGPTFTVTSSYGNYGNHDKDDTKVDVFYGSREKLRLFITQLIATFKLNRTRYITHKDKKGSATQYYALFKRLQAKLDWNNNILIATFYTDLKDNIKKELGPERPNIYQGLVNKAIEIDNWLYKLGLEKKGYHKKTSGAYYKGKRTNYQSYGDPIDLDVIEQGWSSRLKGKFQRKGLSNKEREQRKKENLCYNYGNPGYRANECGTKPVELHIIEAGIEEEKANTPIKKELKRLRLKSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWD5</accession>
    <name>A0A0D1YWD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239802.1">
        <property type="nucleotide sequence ID" value="XM_016374526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWD5"/>
    <dbReference type="GeneID" id="27327242"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00159"/>
    <dbReference type="HOGENOM" id="CLU_020820_0_0_1"/>
    <dbReference type="OrthoDB" id="3596604at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="748" mass="83432" checksum="06C8A54AFA60FE49" modified="2015-04-29" version="1">MENLQAEDGLPLLPLPGVTSLKRPNFESKSSHMGLAEASSEPDGVRIASDHPGSQISEPFFSFKNSSRYKGDKQSIRIIPSASEITLSTIASRLSVPEPWEHDTPDEHNADTVGNTARKFQRGPQCWKVLLSGLPQLLLTVTLCISILLVYYVYLRKGAINQADQALWNYLTLALYLILPMSLSSAFKGYARSYRWQLLSTRYLGLEEFDLVLGCESLIASTQLLWKGRVKGRLMPSRIQWYCAVSLLLNLGLQVAVSVLGVIASLTPSREGIDYSQYGSFSIADFNNPAFFPDNDTRSLSYYIRQMLPFPDEYPTYYFPNFYGNLIWPPWGYRDKDSSSRSIFCIPGDPGCKIYLSASGPEISSAYTNITIFSYHSISAVATCQKYNVTHYPVEDEPIWDPFSRQSYVLGNITFFNESSGQITTIPWNASPVLGQSIEPPTFMWAAHYDTSHPSSRSATVMMLHRVEDRVSLFDCHSEVLPLNQPTGVHGVDLYPVPAVYNIPDEVAQNFAGAIAGRFTVTPKEDPKVYCQYSPLFDDEELVGVTDEWPPEKVASVIRTFTLSALRSFDLLGPRITVAGIGPQQAQKLTINWDWAIGILVGIPVIQWLLLCLTAYISSAAIIKDTSYLATAHLLKPVTENLGSHGCIMSGHDIAHHLGNLPIIYGVRCLAHPSDEPIYHLDVIRQSEDHEANLDNGWKAGMDMPEGWYDGSGRQTMGTIFRQNVSTQLQGSTWEQPRNHITKKAKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXH7</accession>
    <name>A0A0D1YXH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_00541</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240182.1">
        <property type="nucleotide sequence ID" value="XM_016374906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXH7"/>
    <dbReference type="STRING" id="91928.A0A0D1YXH7"/>
    <dbReference type="GeneID" id="27327624"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00541"/>
    <dbReference type="HOGENOM" id="CLU_013691_3_0_1"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002247354" description="tyrosinase" evidence="12">
        <location>
            <begin position="28"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="14">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW19966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="618" mass="67855" checksum="B2DE57A177034954" modified="2015-04-29" version="1">MSVLPSPQAPFLLLLFLFSSLYPGLHGFKITGASGGVNSVTGARPLRYEINEFANSGPAFHLFVLAMMAFQSTNQSDPLSYFQISVGIHGFPQTPWDGVLGTGQYAGYCLHSAVPFPMWHRPYVALLEQILWTYAQDIADIFPEEERGQYKQAALNLRFPYWDWALYPALPDAVSQPQITVNTPEGWQTVDNPLFSYKFQSNAGGNSFPPAHPLAKFGSTVRYYNTSTQQSDQTAATASLRAQAPGLLSLTYQLFTTISDYTLFSCNNPGGNPGILNNIEAIHNGIHSSVGGYGHMSYPETAGFDPVFFLHHANVDRLVAMWQILNPDSYIVPTMNAYGSYYELKGFIDSGSTALAPFHSDAGSTMFTTDGVRNTRTFGYAYPGLEDWNKTQAELASNVRRLINTQYNPLTNTTHTRMSRALSQRSANVADVFGHVDLDMARDMSVNNLEMQWSIAVLVERFAFDTSYCIDFFIGDPPADVTLRPTAKNLIGSYAQFGHANVSLIHPEGAPEGQVGSEVSMTHVLAAGVMRGVLKDLSPESVVPLLQNALHWRARTTTGDDVPLEAVSGLSISVYSRSVVPTDADDRFPQYGPVQWQRSATNGKPCGSSWPSTWAQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YY24</accession>
    <name>A0A0D1YY24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1 cell morphology protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240397.1">
        <property type="nucleotide sequence ID" value="XM_016375121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YY24"/>
    <dbReference type="GeneID" id="27327839"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00756"/>
    <dbReference type="HOGENOM" id="CLU_037771_1_0_1"/>
    <dbReference type="OrthoDB" id="5389892at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF1">
        <property type="entry name" value="PAL1 CELL MORPHOLOGY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="40464" checksum="3699C81DFEADE056" modified="2015-04-29" version="1">MGSSEDKEWASKYLLDPLNAPEPSQEDGPGNAFRGGPSAPPKATPPNRAYSGRRLSKNNPFHKSSKSDVGTTEVKRSISLHSNGTVPKTPSSPPTAYPSPPPSANSPNAAFSPGSPRSPSYRQEALGEHRPGRRRGSSLTERYPGDMSHRPLDTLTKEKHVADRSRHVTRKHHIQPDTIDSLDHSGGTAWHHGGPYDATLFARNNSSNSPLAALADSNAEALRATPKERVIDSVFRHRPLDGVATYAPGDTDRMGNVYNYEEGDNMMIESGPEGGAYKRWPGIQYLPEDIKGKGEPSYSIEKALKEHRIHDNSVGSDGIEMETKSRHRSSSGAAPRSNWDDGEGQIGRSGSFKRLSGGLKKRFGSIKKKSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZI8</accession>
    <name>A0A0D1YZI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240952.1">
        <property type="nucleotide sequence ID" value="XM_016375676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZI8"/>
    <dbReference type="STRING" id="91928.A0A0D1YZI8"/>
    <dbReference type="GeneID" id="27328397"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01314"/>
    <dbReference type="HOGENOM" id="CLU_013601_1_0_1"/>
    <dbReference type="OrthoDB" id="5338195at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057558">
        <property type="entry name" value="Swc3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24707">
        <property type="entry name" value="Swc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWR1-complex protein 3" evidence="2">
        <location>
            <begin position="80"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="651" mass="70273" checksum="9BE1AE53FE259F4F" modified="2015-04-29" version="1">MTDPAPPRRTLPARERGDSRATKRRPSSPAQPVAAPTPGKASTPTPSLEPPRQKRKYTKRVKLVGATDATEEALPTRFGAHKPLPTSAEKPPTDLSPNEYQSIAESAVLAASLHHSRMQWLCEGVFKKYWVKPVKRKGVIEAPPNNPDVKSMQKLGGATVTIEPHIFDVVFYTVKDPSAPQLYQRHANQHTAKHMIPPAPPYGMYQPPGSHPIPRPPAQVPPPSQRPTGTPPVPNMASQAQPQPTPPAGHPAKLPTPTGPTGPPGDSTQQEAVPRQEQSTPVPPKQVSVAPSPKASPSTPQLPPQPPQKTTNPPPGPNGRPTTTDPVIQMLAARAASDPKLKELMKIVATSKASPEQLKEFQAHIDEFNEVVRRQEAERRSKAAEQPPNSKSSTPVAGGGPKPVQPESKPPTPQQAPTSHIPTPSPAPVAAHPSTYGTPQHQARPTPSPSNSTPGSVPKFPPQPHGLGPAGYGGYRPVPPPPPPRTEPIIKHIVLEITSIPSGGQQASTDRWLFPEYAVLELRQGGLEMLCSFLVERRGSDVLASKGDQPSDEGSKWKADQEYYEPVTMTVRATHHRTIETIARAAKLLPEVQAHMKNVLEKAERAPREYLMHQLPRDEGADTTEGFIDSGVELGNESASEDDELKDIYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0Y3</accession>
    <name>A0A0D1Z0Y3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241527.1">
        <property type="nucleotide sequence ID" value="XM_016376251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0Y3"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0Y3"/>
    <dbReference type="GeneID" id="27328974"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01891"/>
    <dbReference type="HOGENOM" id="CLU_013635_0_0_1"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039510">
        <property type="entry name" value="Vint_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032838">
        <property type="entry name" value="Vwaint_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF156">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14623">
        <property type="entry name" value="Vint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14624">
        <property type="entry name" value="Vwaint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="82"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="775" mass="84190" checksum="05B46DAAAA26BAD6" modified="2015-04-29" version="1">MTRSGKTARSVSSTGDDDFFMVTEPEPESQATFELPIRANPTSNTQHGISVEVQALQQSNHLTVSIQPPKQPEQDLERAPCDIVLVIDVSGSMNDAAPQPDVKDPIESQAAGLSVLDLAKHAARTVLETLKADDRLAIVTFSHDATIVQGLLPMTHDHKRDTAKRITSIRTGSYTNLWAGIRAGLKVFEKTKHVGNFQGLYVLTDGMPNHMCPQQGYVAKLGPMLSSLSTKIPTVPTIHTFGFGYGIRSALMQSIAEIGNGSYSFIPDVGMIGTVFVHAVANLFTTFATSAMVEVTVPDNMAVESIGLQDFVIPNSTGTSYALRLGNIHYGQTRDLVFAQSGHGALPQGKPISVTLKYKLSTGVEYSIDSGLTLSSATPGLDRRTSEYRLFRARMCALLCTLFPLKQNGEHGHIIEPEKLDNAGMSLSALARDIRAALANGNGADERLSSILQDLEGDEPAGQVTKALTNSPRRPYWTRWGHRYLPSFLHAHQRQLCNTFKDPGPLVYSTTSPLFIKYRRELDSAFDNLPPPQPSRPERVVPVYDEHGEMTGTRSVPHSRVASMRTWNKSDTPCFPGHCQVKLGGPEDGDMKAWDVVPGTTVWTPVGPRKVHSVVKTELVEPVAICKFAGGLQITEWHPLLHEGTWVFPHDVATFTTHTKDNVYSFLLEPDDNPDAHAVKVRGRICVTLGHGVVGGGSGDDDGDDNGRVDARSHPFFGDWDKVSTSLDKLNKDEGGRCVCAGLERDDLTGLACGFTGPTEPEGLEGQAEAEDTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAP1</accession>
    <name>A0A0D1ZAP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_11037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230293.1">
        <property type="nucleotide sequence ID" value="XM_016385349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAP1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAP1"/>
    <dbReference type="GeneID" id="27338120"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11037"/>
    <dbReference type="HOGENOM" id="CLU_877269_0_0_1"/>
    <dbReference type="OrthoDB" id="2571985at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW10077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="317" mass="35100" checksum="E02A9612ADCC3C4D" modified="2015-04-29" version="1">MSHPLSPSASTHLGVSRVLKRPRAARACDRCRLKKYRCDELSPCSQCRKGPFDCIYVGGYRPRDGNRGGFPTTSATPMSTETCYQTSEPSLNQPLSGTLPRESVANDKIVALDLGGGQLAATVDDTSSVDFVEEGISEVNQHTNSIEYHGNTSSAAFLGRLQSRQRSGHSIDAPGSPKSSLISTLHNPAFSLHATPTPSALKDRNFYLDYAHTFIQGYFDNLHYIHPMVDKSEFMARAHLLWFSKSPQPGPSFVALYLSLLSLGALIRTWDEGRLGGLSRFEWSRRLYGEAQAYLNRLQFSNDLDTVQALFMMVRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAT0</accession>
    <name>A0A0D1ZAT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230338.1">
        <property type="nucleotide sequence ID" value="XM_016385394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAT0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAT0"/>
    <dbReference type="GeneID" id="27338165"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11082"/>
    <dbReference type="HOGENOM" id="CLU_120084_2_0_1"/>
    <dbReference type="OrthoDB" id="15981at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774:SF1">
        <property type="entry name" value="NGG1P INTERACTING FACTOR NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="128" mass="13834" checksum="4F75FF677FFA7E4D" modified="2015-04-29" version="1">MAAESENPDTLLYKLTFYVPQSHTQTCLDALWSTGAGRWPNGPRASACEPPKYTDVAFISPGMGQFKVSAHATPHIGTPGNGEAEHVSEDRVEMVIVGTATAKSAVAKLREVHPYEVVALFVVQCEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZCJ1</accession>
    <name>A0A0D1ZCJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230973.1">
        <property type="nucleotide sequence ID" value="XM_016384371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZCJ1"/>
    <dbReference type="GeneID" id="27337139"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10056"/>
    <dbReference type="HOGENOM" id="CLU_079417_0_0_1"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="64"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="244" mass="27914" checksum="6BEAAAF6D253AFEF" modified="2015-04-29" version="1">MAATKSIYRVSIARSCCARPASLSSSIRPLYQSRFQTTVSPDIVNKLDETTARMSSANTGPVSDLIKHDHAELKEFYENVLRASDEDAKVRWQNQFTWELARHSIGEELVVYPAMENYMGEEGKRLADKDRAEHNEVKELLYKFQGLYPSDTDFEPTLKSLWNTLSQHIEEEETEDLPKLEDALRDYDPDYSAHLAKSFGRTKKFVPTRSHPAAPDKPPFETVVGLMTAPLDRLGDIFRRFPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZF92</accession>
    <name>A0A0D1ZF92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_10974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231888.1">
        <property type="nucleotide sequence ID" value="XM_016385286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZF92"/>
    <dbReference type="STRING" id="91928.A0A0D1ZF92"/>
    <dbReference type="GeneID" id="27338057"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10974"/>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="73"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="501" mass="56553" checksum="34C8EEAA43A2D93E" modified="2015-04-29" version="1">MAFHGDSKEAVFKNASASVEGDGQSPSSLHSPSLTFDDVIQAKPSRTWKSYVWDSLDKSPEERRFLFKLDAAVLTFASLGYFIKYLDQININNAFVSGMKEDLGLYKNQLNYMQTCWTVGYVLGEVPSNMVLTRVRPSIWIPTMELIWTILTFCTSKCNSAGSIYAIRFLVGLAESTFYPGMVYVIGSWYRRDELAKRSCIFHTSSAIGSMFSGYLMACVHHLGGRGGLKGWQWLFVVDGVISLPVALSGYFLLPDVPEITRAWYFKPHEREFAKKRMKLEGRADRAPYTKAKFKKIFTSWHIYFLVPLYMLFNNAGSGVSQPTFAQYLKHSKSPKYTVSQINVYPTTTYAVQIVSTLVYAWTSDTIFKGARWPPILFGASVNIVSYASLAVWDIPTGWHWACYMLAGCGGGLSGLCMAWAHEICSEDNEERAIVTGSMNEIAYVFQAWLPLVVWQQIDAPEYHRGFVTSACLSAGLIVVALAIRWLWKWELERKKHISLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZLY6</accession>
    <name>A0A0D1ZLY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MATE efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234073.1">
        <property type="nucleotide sequence ID" value="XM_016380971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZLY6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZLY6"/>
    <dbReference type="GeneID" id="27333720"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06637"/>
    <dbReference type="HOGENOM" id="CLU_012893_1_2_1"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="54174" checksum="1D5271ECFB422714" modified="2015-04-29" version="1">MAGRRPSETSALLNEHGIDDFRKSIAQVDQRVYGTAAEEEVPLVKNPEIETTWKAETAILARYSGPLILTYVLQYSFSLVTVFVAGRLGTKELGAASLATMTANVTGLCVYEGLATSLDTLTSQAFGNNKKQLVGLHVQRMALLVCVVTIPIGAVWICSPWILSALVPEKAEAMLAGTFMRIYLLGAPGWAIFEAGKRLCQAQGDFTASLVVVVICAPLNILWNWLLVFRLNLGFAGAAWAVVISNNLQPIVLAIYVSCFARSNLQCWPGLQLRRACQNWGPMVKLAFPGVLMTFSEWLAFDVLSIAAGYLGQANLAAQSVLMTVAVTIYHLPFPISIAASTRFGNLIGYGALNAARQTWRTHYLIFVCIGLFDVTLLTSCRHIIAAIFTDDGSVRTIIAQVIPIMAAAQLFDALVAISNALLRGMGRQKIGGWVNLGVYYLFALPLAFFLAFGPPDMGLSGMWIGPCCGLGCASLIMFTYMKFTDWGKAVEDARAREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZMX3</accession>
    <name>A0A0D1ZMX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06958</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234393.1">
        <property type="nucleotide sequence ID" value="XM_016381291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZMX3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZMX3"/>
    <dbReference type="GeneID" id="27334041"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06958"/>
    <dbReference type="HOGENOM" id="CLU_428285_0_0_1"/>
    <dbReference type="OrthoDB" id="5130013at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="663" mass="75313" checksum="7D99BCFDCCCA606A" modified="2015-04-29" version="1">MSGVRKRRKTGCLTCRQRYIRTPSRERRAHLLNSSRRIKCDERKPTCERCEASNIHCAGYEQMRYIDVRHRAPAESPQYQTPSDSATSTRSPSQPVAHFERDGLPLIALPNNPTPVQRPHSRARDILAYHQYIFRTVPVLFPACYFHFWRDMLCQEAWETECIYDAIIALGSLHRASLLLARSEDNARSRGADTKVTALQTYTIAIEGLSRQLKSQPPAPDVLVAVLQLLAYFECFNGNISAAIRHYHIAKYFYLSLSLEEGNIDSLLPIKSSLRHVSFLCRVMLPLPISLFGAENSCRLHPDERRRTHFLGRDKDGPLLSEYMHQLLDVFSAEEFVADLVWNSFVKNIEDVSSERIMSFLLEVDDWKKRFNDPSLKSAAEQYPSGLSRRDIDGLLSTQLQQRPQRTYQYALTAALYHFCMARLMWALSRVNGDDEVYELSAYFHVNEVVQLSHCYSDTTGVGQGRDQDHWVFGEALEIGFSAMLYLCGQCCPCNLWRDFIIERLQLIGREGVYNGPAFATALTILRAFEPVSNTAAPHSSMLGRLGPPRSRVIPLLFTQKDGQGFKLYLLGPAPNRSDPVLGDYEVLSLSQWTTDEQGAMQEPVTETFGGNNNTTQPAGPPRPGSEWLLSQSVIIDWMDTFRSSEFDVELAIRDHIDGVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZN56</accession>
    <name>A0A0D1ZN56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234498.1">
        <property type="nucleotide sequence ID" value="XM_016381396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZN56"/>
    <dbReference type="STRING" id="91928.A0A0D1ZN56"/>
    <dbReference type="GeneID" id="27334147"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07064"/>
    <dbReference type="HOGENOM" id="CLU_1896223_0_0_1"/>
    <dbReference type="OrthoDB" id="5227693at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="134" mass="15644" checksum="2394985AFA82BA86" modified="2015-04-29" version="1">MAMTLHVEVNQQIHENEENKGERNEAQRTAPRFRAALDSPGRGLHKGLMEAVDRYVDCAIERQTIVESYQEKIRELKDSQGRQPATLSEEQIRTGWCTMMLRGCLWSMVHFPIWLPNLPYPSRYWKNNTLVLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQX7</accession>
    <name>A0A0D1ZQX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extragenic suppressor of kinetochore protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235428.1">
        <property type="nucleotide sequence ID" value="XM_016379601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQX7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZQX7"/>
    <dbReference type="GeneID" id="27332340"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05257"/>
    <dbReference type="HOGENOM" id="CLU_003676_1_1_1"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="805"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="805"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="958"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1034"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1072" mass="118594" checksum="FCE6D7679940153C" modified="2015-04-29" version="1">MFWRFGGYSNISTIDTILDKPNVKLEDLLEESDLIQELKSHHTKLIEFLREDAHLHSLLQYVIAPGPSNDEFEEDEKGKDPVIEDEQESNADEEQEKVEKRRLKYAFVACEILSCETWSITESVMANTPYLIEFWDFLRQPAPLDPLQAGYFTKVNETLLEKKTEDMLDFFRSLPGIVPAMLQHVDCPMVMDLLLKIISLEKSDGGAGIVDWLHDQDLIPMLLSNLSPDCNSSTQTSAGDFLKAIITISANAAQDQQSCIGPNSLTRQLVSEKCISQLISYMLKGGNPLTVGVGIVIEVIRKNNSDYDPDQGHNTDIPPTNHDPIYLGTLLRLFAQHVPDFTELILSSKHTVTKGETTTIEERGVLKSAWGTHIEPLGFDRFKTCELMAELLHCSNMGLLNEPGSEELIKERDAERERLRQQGVFLTHRQPEDSAVDISVTSSRFENSFAPSASASTEELQIATLGEEDGFEKVAVADATEAQKDDLKSFEHVTTEEPTTSHDNLDETVRRMSLDNPEDTVMTSPPNEPETNVLDQEPAHSDDKPAPLFSSDPNKTPTANSPEPPTSPNGTKQAGQDNQLEGDSFQTAQDDTTHNCPTEHDAESPVVGDYLKIMFIENKVVPTILSFFFRFPWNNFLHNVVYDVVQQVFNGPMDRGHNRLVAFDLFETGRITDAIIEGQRRSDEEQQNKNMRLGYMGHLTLVAEEVVKFGERHPRELLSPTVQDYIYSQAWEEYVTKTLAETRERDNAILGGFRPDNGLGPRQAVLSAVNAGQGFGASSGLAAAGLGGQPLDSIDLSNNGSATSAGYNSNGSLSSGFGSSSDDDDEDMDDAEEDEHRQLAAADSGLTENSDQPIPLLPPPPAPLNIEPSRARRRLADRLARHKQEAEQEVAASEFGSEADDPFAALGNDERDPFSLDEEEQDITTFGKRKAEGASPDFSVSRGLTSLFAPSRNASHDDFEESLDDSSSDTGSDIDPENPPLEARTSLERRPLEVFEDEEMGEMVAPTEGGNSSDEEVLSPLEKEKLGRAFGMNDPDEQDSEFAGQDDQDDDDDGDQLVEIAMPTTSRRKSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZRL2</accession>
    <name>A0A0D1ZRL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235633.1">
        <property type="nucleotide sequence ID" value="XM_016379806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZRL2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZRL2"/>
    <dbReference type="GeneID" id="27332546"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05463"/>
    <dbReference type="HOGENOM" id="CLU_015502_2_0_1"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="643" mass="70820" checksum="3F6D570EDD17216A" modified="2015-04-29" version="1">MSTVENDSGTSTSVSKSRSKPPSLLACIPCRRSHLKCSGEKPLCKRCADRNGDCFWVDSRRGYREFRKNQPERSTRNDAIFNESQTPHPEPPFVDEADTSEIRTLTYDELFPDDLVDPMLATMPLELQTLPGPRAEGDSPGGHSDSTMSLPRETRSLGVVRAGDDLIELFYKHFYPCHPFVAPKKMYLDDPSILPRPLRVVIHYLASHYVPGTNQTALGNAAKCIFAEDVPDDGFKVQGLLLYAMTCFARFAQKEGAQALSQAIEIALRIGMNRQSFAIQHGRNDPTVQEMWRRTWWTLFVIEGTAVVMGGQSQPFQLYSTFNDVPLPGDDEDYNDLRASPLPRSISDLRDRIISEDTYAYSSFAYVVEATYILGSVLALGPDTFAVTDPQVEAIDASITNYFLSLPPGKREIVGQCGRVDECLLMAHLLANWAAISLHRPRSSLTFIRNHYRTTCTRAEAAGLPALAYSSHTAKALRAANNIISLATVQHSMSYAPPVLVCGITTAATVHLPAYGLIDRPDQATAIKERLKVAISALAAFGEIWPRANIAKGQVARFAREVLTKPNVCISSAGPDMIPRITSDPIPQLQYDVPFNGELWMESLIDSDANVGEGQACTVFDNFSMSQAQSTATLCIPALQSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTG0</accession>
    <name>A0A0D1ZTG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-ascorbate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236263.1">
        <property type="nucleotide sequence ID" value="XM_016380436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZTG0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZTG0"/>
    <dbReference type="GeneID" id="27333181"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06098"/>
    <dbReference type="HOGENOM" id="CLU_006504_8_3_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13873">
        <property type="entry name" value="CuRO_2_AAO_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13895">
        <property type="entry name" value="CuRO_3_AAO_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035666">
        <property type="entry name" value="MCO_CuRO_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017762">
        <property type="entry name" value="Multicopper_oxidase_fun"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03390">
        <property type="entry name" value="ascorbOXfungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237961" evidence="5">
        <location>
            <begin position="20"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="35"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="162"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="415"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="596" mass="66628" checksum="86B498DA602E88FD" modified="2015-04-29" version="1">MLLFYRLLPVLFWIQAICAIPPSPEASPDYVLVATAKNLTVNCQTRYSVVLNGTSPGPTIHMKENFTTWVRVYNRIPDENLTVHWHGLSLRTSPFSDGTPQVSQWPIAPNAFFDYSVTPAVGDAGTYFYHSHAGFQSLTAQGLIIVEDQDDVPYDYDDDESFFIQDYFPKNDSTIVSGLIANPFKWSGEPEAISINGFSGNSSFSNATDATCTPYVINVEPGKTYRWRFIGATALSFVTLGIEGHDHLTVIEADGEYTKPWSTDHLQLGSGQRFSVLFKAKTQAELDAANKTSFWLRYENRDRPTNVSGYALLQYNVSGSTRPSLLPATPPITLPKNVTTWAEYALEALRPQEAFPKLSEVTRTVYITMQQQIRVGSYVNKTINGTLQWAQNNLIWQTAQRESNNSLPYLVQVYLTGQTPNYTAAVENGGWDPYSNAFPALPGEVLDIVWQSNSGPTGGWDFHPMHAHGKHYFDLGSGNGTYNATANEMRFANYTPARRDTTIMHRYAVSGVPETTAGWRAWRIRVTDDDVGAWMMHCHVLQHMVMGMQTVWVFGNASSILAKFPTQPYVNGYLKFGGDAYGNSTYDPLENIYSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZV52</accession>
    <name>A0A0D1ZV52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236813.1">
        <property type="nucleotide sequence ID" value="XM_016378136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZV52"/>
    <dbReference type="STRING" id="91928.A0A0D1ZV52"/>
    <dbReference type="GeneID" id="27330868"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03785"/>
    <dbReference type="HOGENOM" id="CLU_021768_0_0_1"/>
    <dbReference type="OrthoDB" id="4105646at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="306" mass="35374" checksum="B4D9D713C79B4004" modified="2015-04-29" version="1">MSSTHEPGLREQDHDLLPDTLEKAALEKDVDFTESSFFQVGRARRLPAVPSVDSNRQGTLVVSEMRLLIKFGPHVTIDEAVTMRAVRRRLGHRVPVPEVFGWRVRQDRVFIYMELISGLTLQEGWDDLNLSEKDSLCEQLGQILSSLLQLEQRDEFIGSVTRGPLLDRVFYDRPETRPFDGLDNFYNFLEWLPQRFLSTPQRHRDPYLEPLRLGEADPTGIKFTHADVHPTNIMVSASSNLGPPRILALIDWGQAGWYPDYWESFKMCYTTDPEGVWRNTYIPKIIEPREYEQYLLAEYTMSIGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZW32</accession>
    <name>A0A0D1ZW32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_04087</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237113.1">
        <property type="nucleotide sequence ID" value="XM_016378436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZW32"/>
    <dbReference type="GeneID" id="27331170"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04087"/>
    <dbReference type="HOGENOM" id="CLU_142427_3_0_1"/>
    <dbReference type="OrthoDB" id="5566853at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW16897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="100" mass="11056" checksum="88C9B07A24F414AD" modified="2015-04-29" version="1">MATSHNAFAADAPHSSEFETRRAALVNDIGESLEQVLTHINALNRSLEGIIEIGNEFASVEALWSQFETVMGREEEVAQNPSTQDDTEESRVEHDRASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWV0</accession>
    <name>A0A0D1ZWV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial adapter protein MCP1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237383.1">
        <property type="nucleotide sequence ID" value="XM_016378706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWV0"/>
    <dbReference type="GeneID" id="27331441"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04358"/>
    <dbReference type="HOGENOM" id="CLU_060790_0_0_1"/>
    <dbReference type="OrthoDB" id="10259513at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012472">
        <property type="entry name" value="MCP1_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07950">
        <property type="entry name" value="MCP1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial adapter protein MCP1 transmembrane" evidence="3">
        <location>
            <begin position="188"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="323" mass="35157" checksum="EB28E61907D00F80" modified="2015-04-29" version="1">MASDLPPLTTSDTRASSISAIPMHEVEPSPVDVDDDDPNALLPAPATAPSSSSSSKLWSFSSTTNFLGLTPSRMLHILSATQKYSTLPPTIYLAMHYANTALIPLATRSAIQSDRYLLLTRPYYQSFPLEPLLIFAPIITHVLSGVALRLYRRRLTAKRHGAETHAQRKTIRYAPLSTTSAAGYALYPMFVAHVAMQRVVPNKVEGSSAGVGLRFFAHGVAQDPWFANTFYAVFVAVASWHFVTGAAKYLRLSREYVTEGGESGAVRRKWRTRIVNGVAAAVASLWIAGGLGVVGRAGPGVGWEAKNWDRIYAAVPLLGRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZ66</accession>
    <name>A0A0D1ZZ66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05147</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238168.1">
        <property type="nucleotide sequence ID" value="XM_016379491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZ66"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZ66"/>
    <dbReference type="GeneID" id="27332230"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05147"/>
    <dbReference type="HOGENOM" id="CLU_006937_8_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="9">
        <location>
            <begin position="35"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW17952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="564" mass="63667" checksum="D30094B8E7276CDF" modified="2015-04-29" version="1">MTSVPPNMSTPEPTVNGVHDSASNGRPSFNKLDTDIIIVGGGFGGIYGMYKFRKLGMKVNLIEAGAAFGGTWFWNRYPGARVDSETPYYCLSIPEVYRDWNFSERFPDHVELREYFKHADKALDLSKDTYFNTIIVGATYDSDSGKWKIRSADGETATCTYLVMATGSSYKTHSPDFKNMPQYKGLIVHSARYPSNLDVTGKRICVIGSGATGLQIVQTLAREDCEVTACIRTPNLSLPIRQRALTIEEQEMNKNFYQSWLHAAKGSKSGFPYDPAPKGYFESTPEERQDWWELLWKRGGFSFMGGNYMEMIFNKDANREIYKFWVEKTRQRVKNVEKRDIVAPLEQPHWFGTKRPSLERDYYEMIDRDNVKLVSLKRNPIDHFTETGIRFGGEASFDADFDVVILATGYDAITGSLLDAGIVGKDGISLNERWKKGISTHLGLTIPENPNLFMVYSPQAPTALANGPPLIEIQVDWIAAALEAMQEQHIKSITPDPAAAQKWRERIQEVCNLTLYPETDSWWNGGNVPGKLKEPMLYMEGVDTYNSVITAALKNWEGFQVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A032</accession>
    <name>A0A0D2A032_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_02630</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238558.1">
        <property type="nucleotide sequence ID" value="XM_016376988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A032"/>
    <dbReference type="STRING" id="91928.A0A0D2A032"/>
    <dbReference type="GeneID" id="27329713"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02630"/>
    <dbReference type="HOGENOM" id="CLU_002173_0_0_1"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000053">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000074">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="473"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="135"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="251"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="154"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 11">
        <location>
            <position position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW18342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="806" mass="91400" checksum="D739C6FC6BE1FD6A" modified="2015-04-29" version="1">MPEANLPAEPNLRVTIIAADGLYKRDVFRFPDPFAVATISGEQTRTTSVIRKTLNPYWNESFDMKVTEDSILAIQIFDQKKFKKKDQGFLGVINIRIGDVIELDVGGDAEMLTRDLKKSTDNLVVHGKLIINLSTNLSAPPPNPQANRPPASSTPSINGSASLGSSTNVNQSLPIRSRSPAPSRTATSGSGEARASTTAVNGAGPQVSTNGSGRTGGFSSFEDSQGRLPAGWERREDNLGRTYYVDHNTRTTTWTRPSNHMSETEVRNRLDANMQVERQRHQNRMLPEDRTGANSPSLQESRTGSPSQNSVAMMATGATTAGTGELPAGWEMRHTPEGRAYFVDHNTRTTTWVDPRRQQYIRMYGNNPAGNNTTIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQGVPQYKRDFRRKLIYFRSQPALRILSGQCHIKVRRGNIFEDSYAEIMRQSATDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGINPEHLNYFKFIGRVVGLAIFHRRFLDSFFIGAFYKMMLRKKVQIQDMEGVDEEYHKNLTWTLENDITDILDQTFSIEDEQFGETKTIDLKPGGRDIPVTNENKREYVELVTEWKIVKRVEEQFNAFITGFNELIPADLVNVFDERELELLIGGIADIDVDDWKKHTDYRGYQEQDEVIQNFWKVVRTWDAEQKSRLLQFATGTSRIPVNGFKDLQGSDGPRRFTIEKAGEINALPKSHTCFNRLDLPPYKTYDVLNSKLSTAVEETLGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A1F3</accession>
    <name>A0A0D2A1F3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239013.1">
        <property type="nucleotide sequence ID" value="XM_016377443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A1F3"/>
    <dbReference type="STRING" id="91928.A0A0D2A1F3"/>
    <dbReference type="GeneID" id="27330169"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03086"/>
    <dbReference type="HOGENOM" id="CLU_1156268_0_0_1"/>
    <dbReference type="OrthoDB" id="5244524at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="260" mass="29521" checksum="A459B54884DB48A3" modified="2015-04-29" version="1">MYRKRNGSLGFSFTRFAHAAVPNFFADESPVRTANLISYRRDMCYMHQIASPDPYALDERSFYVAGVVDSESVSRKVHRALKKCSILGDDGIVDTHKIGPRFPHQLALLNIPRQKDLVGMLFWWEEECQRLRKLNAEEEELDELIAHAEVRVTVATEGAARGELREDDHGAKLALDELKFARERVRMKKRQRPSQRRVDVEEDKDDIVMAFHGRSKSVPNMPGQLRVSGTTSAGNDDNRNGVEEAHAEDHGPPPGYLPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A223</accession>
    <name>A0A0D2A223_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239198.1">
        <property type="nucleotide sequence ID" value="XM_016377628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A223"/>
    <dbReference type="GeneID" id="27330354"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03271"/>
    <dbReference type="HOGENOM" id="CLU_729647_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="379" mass="42467" checksum="34FC96D420265CA0" modified="2015-04-29" version="1">MEAATGRHDEVEVEWARLLANLESYNRQTASQTVSKSLEPPERTQSIQSAREDPQTHQQCARIDLIDNAKAQEPATDSHKAKYVERHTRPDGSLLPSAFANDFTPRPTRQRRARKTGHTGVSPWARQAMETRWLLSLHQSREKDNGPPTPIHQPRPYPGGVTNAVVRERLGVVGAHWTSPAQDLSDAVAPMRASRQSGLAGDASPATGMSHGGTSDLAGSRPSDSRDGTMANAGAEQEEVYFAVDRPFTLYTIAGEKRTVNELVWRLFDIPIFGWTPRYPFMSAAPQPGQFQQDPGEVYVSRDVSYYGSDRETANETDLNASRVVANSPDNEAHMSRLRLTRSEPLHDWPRRSAIDDYYEEDSDDDEPTRPGHHRRRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3A3</accession>
    <name>A0A0D2A3A3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239593.1">
        <property type="nucleotide sequence ID" value="XM_016378023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3A3"/>
    <dbReference type="STRING" id="91928.A0A0D2A3A3"/>
    <dbReference type="GeneID" id="27330755"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03672"/>
    <dbReference type="HOGENOM" id="CLU_015590_2_1_1"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="277"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="553" mass="62442" checksum="B2D024F954E212F0" modified="2015-04-29" version="1">MPNKIRSDLHKVDTTSFEYIYEENATIPLSEGRGIVRCNIFRPKAAEGVKFPVLVTYGPYGKDVHYSVFHASSFGEVPEEHHSPHSAWETPDPGYWTKHEYAIVRADEVGLGQSPGVLNTMSRDTSLAFKDVIEWVAVQPWSSGKVGLLGISYYAGSQWRVIVNQYGRPGRAARNWGPDTIEGNLPEEELRANCHDQNIDNVQNRFLDDDYYATKDYKISDIEVPMLSVGNWGGILLHLRGNVEGWMNASSKHKYLRFVTGRHDLPFYTKECVDLQHSFLDAFLKGIDPLGWARGEQPKVGYKVRVGDVGFNDAAAETAYPTKYDSQWPLPGTQYTKYYMTWSRGLQDKPSHEEGKLSYKALGDLKNQHLIQFASAPFGEETEFTGHVVAHLNVSVTPEEGSTTKPSDIDLFLTVRHLDSQGKEILYTGTVGDPVPITKGWLRVSLRKVNEKSPRHQDPWHPHREYLSTDYSRLVPGEVYPVDVEIWPTNVVMSPGDRLVFEVSSGDTQGAGLFEHNSKEDRSEEVFAGNNHVHFGKDYENWLLMPLIPAKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3X5</accession>
    <name>A0A0D2A3X5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239758.1">
        <property type="nucleotide sequence ID" value="XM_016374482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3X5"/>
    <dbReference type="STRING" id="91928.A0A0D2A3X5"/>
    <dbReference type="GeneID" id="27327197"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00114"/>
    <dbReference type="HOGENOM" id="CLU_021588_1_1_1"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="541" mass="60692" checksum="D9193C960A8C40F0" modified="2015-04-29" version="1">MLDYSLIKETSRIFNEVLLTDTDLSFPPEFVEAAKKVKFCGGDDQPFVLTPLKITESSASLTALVATAGNVAAAERYGIEYQNVEVNLDVATLFLESVLLPTIGGKPFVRHPHMAKELAKMDLHNSAKPIRSYATGVYQTKDGRWYHLHGSMNAEPTMKMLGVQDVDVSPEGAIKIYADKVAQWDSTEIERVANEQFRQAGVVCLTPEEFFSSEQGKIMAQEPLWTTTRLPAPRKPWPKTTDQHGCRPLAGIRILDVSRVIAAPAVSKILAVLGADVLRVSCNRLPDYAATMPDLQTGKRDTNLDLKTEEGRRIFTELVKGADVLIDGYRPGALKGLGFDSKSLRQLNPSLIYIRENCYGFKGPLAHRSGWQQISDCLVGLSYVQGKFLNLQEAVVPLLPNSDYQTGLAGAAAAIKGLIARTKEDVTFDIDISLTQYNIWYYQLGLYSEEQQEALRKRDPAFSPRHFDDMVRLVGKTHESWTRIRPDMFDHPEYFWEMSGREYGLDENLLVLAPAFKFEKSHIEWEVPTGRRGRSEPEWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A487</accession>
    <name>A0A0D2A487_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239873.1">
        <property type="nucleotide sequence ID" value="XM_016374597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A487"/>
    <dbReference type="STRING" id="91928.A0A0D2A487"/>
    <dbReference type="GeneID" id="27327314"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00231"/>
    <dbReference type="HOGENOM" id="CLU_431493_0_0_1"/>
    <dbReference type="OrthoDB" id="4121103at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="198"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="713" mass="80817" checksum="D232A034E6CBD88C" modified="2015-04-29" version="1">MPPALHRKAGESDRNYCEGHGLIDMLQRQCPKCQHGQVRPNPYAARHHCKLGLRHTISDPIIEIPETLSPMTARKMQVYTSDVWSLLPPHEELIQGCRIFVTTCIQIGFTPRALFLEQLENDRRSVNVFLLVSMLAISARFTPALCKRFGGSSQASEFFAEIAHTMIADEMWETCLENAQAFFLLGMADWGKGDRARSSINMGIAVRMAGVLRLHREETYSLPPDASPTDVVDAERARRTFWVIQNHDNLYTQKHLPASFAKSDITTLLPSSEDDFAFGRVPQVRAALAGTKPAQQDPSLVLIPSRSLFATLVQAHDFWGTIARDFSQDENANTSVEMQPWVPDSRYRKVTESLNQWEQNMPVEHRWSAWNLRGFKAQHVELAYLSIVSIMKLNHVVPRRLYLESIVAKVLGHRANDNAPQGFWEQMSFELFSNVWQLYEIIDAFFTTRSSDDGFPAMLAFCVYICGSLASYLVRWPQLCRELSVSASTTLDRALEILSTLEEKWPTVHDWTLVLRKLSEQPASRESEALRDITSQESFLNSAATSKTPRMTPRAVPRTSLERMHECRTTNSGAPARTSIDNHPQHHHSVPIADRQSPMRPVEPFDHQQPPPRPQAPAPTNFLDLLSDAAALGSDRPRPQPAESSYYSQRQAVEPIRRSVTEEPAQQPQASGSRQQFTLPDFSTFEMLHDSFDNDMADFVHGYVHMGWGDWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7B2</accession>
    <name>A0A0D2A7B2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240878.1">
        <property type="nucleotide sequence ID" value="XM_016375602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A7B2"/>
    <dbReference type="STRING" id="91928.A0A0D2A7B2"/>
    <dbReference type="GeneID" id="27328322"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01239"/>
    <dbReference type="HOGENOM" id="CLU_021599_5_1_1"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="62737" checksum="9EB5A0FAE80424A7" modified="2015-04-29" version="1">MVGVPGRSKGCHTCLKRRIKCGEFSCRSRALERHSLTPPPFLPDESRPTCKRCSKAGYICAGYDRKLEMRFHTFEESAAPLSSKTTRNPPLTTVPKNLVLSSNQELAPLPQELSLVAFRDNIQFSYLFDNFVWSSYGSPWLQMAAAGRLDSLSLEACRAFSLSIFGKHHHQPDIEVSGAMHYDKTVRALSSRLFRVGSPGSEGLIIPITILLMHSSTTPDPQACAFHIQGLLKLVQLCGPARFALDPLRSAFESCRATLITIGLITKSRSFLEQSDWIDQPWSTCGQENKSNQNKLVDILAFVPGFLEDQARLEQWPADDFRLDLIQRIEYQLAKLYNWRWHWEEINPHACWEVDPEVIPSHQFLKNPRPIRKTLIFSTFSRAIDIALYNAVLLCLLGLLWSLSPSTDDGDDDDEALSPPIEPSQTPLNLPGNVDSLTEPAVEICRAFEFQLLNVKNSRDSALFWLLPVGLASRVLEDKPEYVAWIKNMLDSSQITKGYGTGQNTTGFGFYRFPKIKRRRAQGLDYSMIQPQYDSDSLKRYSTGSLPQPQESSGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A829</accession>
    <name>A0A0D2A829_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241148.1">
        <property type="nucleotide sequence ID" value="XM_016375872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A829"/>
    <dbReference type="STRING" id="91928.A0A0D2A829"/>
    <dbReference type="GeneID" id="27328594"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01511"/>
    <dbReference type="HOGENOM" id="CLU_016434_1_0_1"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="387"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="630"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="573"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="652"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="764" mass="83712" checksum="0AB9680E2D2D05CD" modified="2015-04-29" version="1">MAGRKKQQRKPVAAQFPRLRPVEILKNGKIEPLEETPATSFLTLKLDPTKLARFPAASKVFNPCAVKVEKNDNNPSGHDEDQNVTPAAEESAWTSDPTINAADESAGDGEGKSRRTNVRRARLRHPPPYEQHLEPAKSTLVPPGERKRLRERVSSTPAKKVKINPVVEVVSFDPTAELNGSRLAPGAIDHDPDCLISHSPSSFLRLYDADQATEASDVASDITNDTDMSEAPEKSGQRPQLKLKLSKPQLPHAGSQPPVQTPAPTSAIRTPSIKLKLGGPSAGSANAPKPSPSDTVIVSTPASSSQKKRKRVSKAADSEDESTAQPTKPRPAPIPKLTLKTPSVPAGPAKPATATTVKLKAKGKIPKRPIGVGYDSELDEKENDPMIHEGFILRMQPGPDCDYLRKAIEEGTVHLPRSKGGADVKMRMLDTLGRRGIMIIRGNQYAITMVDLPCIIEGMKSWDKKGWIKSIDVCQMLLVLGRCNTDEEARNYPLPEDVDPKNYQYAHGITAPMKWVRKRRFARTKRTRVDDIESVERRVKALLEADKAAKSVRYQLLDHDPRLDEERYSSGLGEDEDAEAEEDEEPDDYFAPQNGHHTAVFDTPMLTETPVEDIGQDEVDEFERMFADDDAPEPETSAQAQSTLHPPEAGDSSFPVTSTSASPSATVAHTPASAVDQSSDSDDDEGGDEDGDLDDADKEGDDNLQQVKDRIEDMQQKIAEQTELLKKTQNAILKKKLARKIQDLKDDVAMMKKNAGLGGDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A951</accession>
    <name>A0A0D2A951_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Scytalone dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241528.1">
        <property type="nucleotide sequence ID" value="XM_016376252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A951"/>
    <dbReference type="STRING" id="91928.A0A0D2A951"/>
    <dbReference type="GeneID" id="27328975"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01892"/>
    <dbReference type="HOGENOM" id="CLU_101889_0_0_1"/>
    <dbReference type="OrthoDB" id="5281072at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030411">
        <property type="term" value="F:scytalone dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006582">
        <property type="term" value="P:melanin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004235">
        <property type="entry name" value="Scytalone_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024851">
        <property type="entry name" value="SCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="6">
        <location>
            <begin position="26"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR024851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="199" mass="23038" checksum="A3486785E16AF181" modified="2015-04-29" version="1">MASDKLISWEANRVRGRRTAKADSDADYQGCLTAYFEWAESYDSKDWERLRKIVAPTVRIDYRSFLNKLWEAMPADDFIKMISDPKVLGDPLLMTQHFCGASKWEKVSDTEIIGHHQLRVPHQKYTDASRTKIKVKGHAHSYNLHWYKKVDGVWKFAGLNPDIRWGEYDFDKVFAEGREELGEDEAKKVAQEAQGIPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASH0</accession>
    <name>A0A0D2ASH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_12088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847507">
        <property type="protein sequence ID" value="KIW09658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229874.1">
        <property type="nucleotide sequence ID" value="XM_016386395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASH0"/>
    <dbReference type="GeneID" id="27339171"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12088"/>
    <dbReference type="HOGENOM" id="CLU_2158398_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW09658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="111" mass="12651" checksum="610EAF2102B34F7C" modified="2015-04-29" version="1">MVASKELKLWRNIILDKLQRLPDQSIPRIIPEQLDWDWERSAHLVCLHYGVSSADPDMSKFWDEERFTRLTEKLSGSAMFPNSLTLGELKSAVNSLALLLGIARGDLQKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT35</accession>
    <name>A0A0D2AT35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_11984</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cut8/STS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230099.1">
        <property type="nucleotide sequence ID" value="XM_016386291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT35"/>
    <dbReference type="STRING" id="91928.A0A0D2AT35"/>
    <dbReference type="GeneID" id="27339067"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11984"/>
    <dbReference type="HOGENOM" id="CLU_033658_0_0_1"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1590:FF:000001">
        <property type="entry name" value="Tethering factor for nuclear proteasome STS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW09883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="301" mass="34120" checksum="432A8DE72504133B" modified="2015-04-29" version="1">MNSLATPPIPPHFHEHTRLSPGRSMSSTAPSRKRKASPSPDRDDEMTTSPSIPNARLPQPVTPSTRKRVRSNLAGRPLSVDRLLETLDKDSLKTVLKTLCDRNPGLREEIVQVSPRPSIQSTLQVLRQYYDRLMQSFPLGPNPRSDYAYDRVRPQWHDLLEALTDFTPHFLPPNEQQSSVSLEYLHGVTNIIHDLPEWDNISYNLAKQNAYEEISRAWAAVIKEASKRGGGIQLQYNGWEVKLRAHNDKSGGRLREAYEALVDALGWLKPTPQPTQQQSIRQQLFSNTYGAEQSAVRTGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATM9</accession>
    <name>A0A0D2ATM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230086.1">
        <property type="nucleotide sequence ID" value="XM_016386278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATM9"/>
    <dbReference type="STRING" id="91928.A0A0D2ATM9"/>
    <dbReference type="GeneID" id="27339054"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11971"/>
    <dbReference type="HOGENOM" id="CLU_562572_0_0_1"/>
    <dbReference type="OrthoDB" id="5426165at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="470" mass="51710" checksum="CE623DD68EE02C05" modified="2015-04-29" version="1">MGQDHILDPGAVFFIEWPTWARLCVVLGALLVLLVVMAICVRLRNWRRNLALERKAAEAEAENGEMNLSVRKSHEIPFGIRALFEDPDVEGVWNSRTNTPLHGPVARLRPRNPPRYTPLSSSNVQPMTVEPELVAPNDREPPSDPIAKVDGASDSRSNGKKFVISYQAPYLRSNPARDPDRDSNAACSRPKISPSKMCLRPPTNRGSNSGRKFVIGNRHRNSPLPPSRDSLSEANVLERMEAHRRFHAAESGQLLPRSRRRHTDLALMTSLASSTSSASDSEDGGSFDAESSQVRSLSLGMPEMNVGKQLARRVEKLEGPKPVPFKAFVESLPAPKPPPSAWTNKTQVRVDAKLPESSKGSETASQFSKHTPNSSISSTCTTPTSPTTSISIVNTRTRKVNSGFEVLPAGTLEKGLDVKQFGVWAENPSITISRKPRKLQKRRSRSSSSSRRSSAESARVSSESFRLPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATV3</accession>
    <name>A0A0D2ATV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_11696</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230136.1">
        <property type="nucleotide sequence ID" value="XM_016386004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATV3"/>
    <dbReference type="STRING" id="91928.A0A0D2ATV3"/>
    <dbReference type="GeneID" id="27338779"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11696"/>
    <dbReference type="HOGENOM" id="CLU_005015_1_1_1"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="13">
        <location>
            <begin position="12"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="11">
        <location>
            <begin position="220"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="12">
        <location>
            <begin position="706"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW09920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="898" mass="101592" checksum="040B99BE0BCF7827" modified="2015-04-29" version="1">MLRKVIELSSGWRYRAVDESSSSPPTATSIWRTCRSLPTEIHLDLLNDNLIPDPFIGKNEEALQWVGETKWEYETNLTVPADALVPESRTVLVMEGLDTFATVTLNGKPILQSANAFMTHRVGLTRDMFETNEGSNLPSSCNDHDESSVTGILRIVFANAEQCGLEIVKQHAEHGWFSLGSSITRLATRKPQYHYGWDWGPKIMTCGPWRPIYVEYYTSRIADVAISSSLSADLQEAIVEVSVEVDGLAEHFVMDLLLHGNVVHHEVVPVRERIGRIQMKLATPQLWWPHSLGPATMYSVQLSLYATQDAEFLIVDQTEKSFGIRKVELVQRGLEDQDGDSFFFKVNNIPIFAAGSCWIPADSFLSRISPRRYQDWIQLARDCNQNMIRVWGGGIYENPAFYEACDRQGMLVWQDFMFACGSYPVHEEFRRQIVAEAEQNVRRLRHHPCLVLWCGNNEDYVIYPLRGIQYDATETSPEAMFKSILPARYFYEHVLPTICADLNPGTPYWPGSPFGGAMVNSPLEGDIHQWHVWHFEMFPYQDFSRLSGRFVSEFGMQALPCLETAKEFFPVEGPCTASETDVLDNQFLKWHNKMADGHDRLRHYGRANISFGTSALDDVIYNTQLIQAEAVATAYRSWRRLWQGPGKEYCSGALVWQLNDCWPVTSWAIVDYHLRPKMAYWAMKRECAFVTGGLSRITKNGGALALDYWAVNMTQNEVKASVTIRAWLVGTGEQVLEQQLHDSVSLQPNRSVDLGILGVDDLKLPTIQQYRDIVFALVVELTETEENLPKTVQAVNFHDPLREVPFPSYNAKVDVAISQSAAGISVRARATVPMKGLLFEVDGDPNAKWDDNGIDLIPGQIAELRYLGQGLRPGQESRLRARWLGGSLDQLSHLRPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVJ3</accession>
    <name>A0A0D2AVJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_11419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230671.1">
        <property type="nucleotide sequence ID" value="XM_016385727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVJ3"/>
    <dbReference type="STRING" id="91928.A0A0D2AVJ3"/>
    <dbReference type="GeneID" id="27338502"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11419"/>
    <dbReference type="HOGENOM" id="CLU_005062_1_0_1"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="207"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="711"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="830"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="576"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="775"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="843"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW10455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="894" mass="99494" checksum="66C749B153E9F3FA" modified="2015-04-29" version="1">MEQTIVEELGPTEKQDILFEVNTALKPEDIPLPRSSMITVRLSDIQSPPELDLDAEVEASPQPSIRQSSPSSTRSSRSSSRTSESSVSIRSVDWEGLEKTEEQEAKDEATDESTALLLARLEKENAALATDPKAGIATTSRPRKNTRPPSIQQLKRMMDGPVRQSLRYSMLPTPGFTELEFWAALVQDYNQTVQRLPTLTSNKIRSGVPAMFREHVWPSIARARDPFLISEYQRLSLEPSPYDALIGKDVGRSFPNVDMFREKDGEGQRMLGNVLKAFSIYDEEIGYCQGLGFVVGPLLMHMGEAEAFCILVRLMEHYDLRSCYLPDLSGLHLRIYQFQQLLTRHLPELAAHLEALKVEPLYVSQWFLSFFAVTCPLPMLLRIYDVILCEGATETLMRVALSLMQRNQKKLMSYTEFEDVMQFLLARRLWDTYAQQADDLVTDFVSLTGLVSPETLQSLETSFRHSQNLTAAPSLKSAAASFLGRFWAGSSHAPSRSANLSLLIPGNNKSSIRKSSSGQSITSTVNSVDTSASEASTLATELSDEVAPKAVMSNLTVVETSASPPNSNDRDLHHQIEELLTELSRVQRQHVDLARELQREREEREEDRRLARALLDRLRQQTDDIKDLAGDDAEEEDGALVGLLDQADHHLGSNDSKRLSIVQSKHQLRDDVSEWKEKHEAEAAKCRELMRQLDEREAEYNSLKESLKEARARIQDSHREKQRLERTVSDLRSRNSSTPDSPADLYTPVDEFPDLKLPAPKSGLRELRLGRPEPQSRSSSVGPFSKRSSSLNTQAFLSTENHEPASNDALLIELANAKTAEAVARQELEETKGKLDALRKIMSGSSSSPGVRVSESPTSATSASVSPGAKDAPKASHTASASTGGFFSGWGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVQ2</accession>
    <name>A0A0D2AVQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231034.1">
        <property type="nucleotide sequence ID" value="XM_016384432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVQ2"/>
    <dbReference type="GeneID" id="27337200"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10117"/>
    <dbReference type="HOGENOM" id="CLU_093218_0_0_1"/>
    <dbReference type="OrthoDB" id="4159201at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="230" mass="25744" checksum="6371E1F82C4A6479" modified="2015-04-29" version="1">MLSTTQQGPGAADLTSDPYQGIPMTDYHDWSFVPSSMYQDNDPNQVVDFFLDSLHEESAQAEHIRRASSVIESDSSDIGSLRHHQLSGSYMLPRDLPSPAPSSSYGRLDLRSAEDTPLRGVLVPVVLSDKERRHRRREQNRKAQHAFREKRKAEARRVENELAELKSQLAKIRYDAATSGWTICVKCRNFFPPGVNASTDADAEPKTPPYVDSLFRSSGPSGRDDCHRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVW9</accession>
    <name>A0A0D2AVW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231094.1">
        <property type="nucleotide sequence ID" value="XM_016384492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVW9"/>
    <dbReference type="GeneID" id="27337260"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10177"/>
    <dbReference type="HOGENOM" id="CLU_004790_4_3_1"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW10878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="588" mass="64291" checksum="9A0C9BC4A1752FA5" modified="2015-04-29" version="1">MEIEEPTSNVEVTPSSPCEHQSSKITTSSQDVEKCSMVASVPSKHQPVTSTLSLEGVNQKIRSVPGSLSWTARALLVWLILQFGADSSVPTSNFMIFPLPKGRNGAGAPPSGTQETAGALGLGLKTTTTIGTAFSFLFPVFSVVFAWLADVTFTRLQIIMWSNIMGCLYLALMLVASIPSVIASGHAAIPFMIGMAGKQIARAMVPVVIVPFILDQCSPTVDYFSTLASGERLLVKRQLTEEKVAYLTNGLVDAGGFLSIATTLFEKRVGFWLAWLVPFSIRVVLLLSLLLLRPRIVRNQPEKKGMSKIISMLRMLIRQTGWRFLVHDDAWETVKPSRLRNGDTTIEQNRGVVNWEDADMDALQRFYHACKIFCILPPYFLVGPMLGNLLSAQGSSMTTNGTPNDILDNITSAAVIIVSYALPIWIFPFLRHHGIKIQPILLITVGCTLIIVAAMIGGFLQLHIYHTSPCGYHATGCTKGTGVSPISIWAQTPIYILQSISIVFTVSSVLGVACHFAPRNMMSVSISAMISVYIIKDAAGLGLAQAVSDPYLVWVWFGPALVMSVLTAMFYWSFRHLDEELSDRVRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AW17</accession>
    <name>A0A0D2AW17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230876.1">
        <property type="nucleotide sequence ID" value="XM_016385932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AW17"/>
    <dbReference type="GeneID" id="27338707"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11624"/>
    <dbReference type="HOGENOM" id="CLU_024751_0_0_1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF146">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="78236" checksum="8D8AD865CD8772B6" modified="2015-04-29" version="1">MWEKPIHCYVFVNGPQYEVSISLTNKNKPFGKDVIVYKMADQAGTWQAGLFVATPTFQRTTKGPWANNRMVLDSSNISGLFETVGKLQLVVKVNGTECCFEWQEVDSLWGGLGSGTMKDVGFQKTTIFENHMVQFTLYDAGPGLAGLPRSHQLNVTVAPKRSNWMGDVAPSGSPQEQKSFRKFVLPCAHDCGIFSMETVQKLAGLSMDKWSMIQEAVFPLTPQYLQPFRALSPGLILKVVEALSRTQKDDIKTQLALGARYFEFRASKIPSCPPWLSDEYYFHHNMIPGVPLKTFFHDVVEFLGENEQEIVVIRLEFNHYSKSHPDKDFVRRLLDSELQASIANGNQLKTISFPPEERTIAELRSNDERLIFFFNDEPDAQPYDNYSSDRHADLKGDRIIAEFETYDIEEQTRATNPTQFTIFQCQGTASENNDVVANTVITGGNKCLLATKAICDAKTLPWLTTKALDRLADDHLGVIMNDFFDLATSDVANLLSTLRLLDQDSHFNFFPYEGEPKPKLTIEAAYWADLNVKPNMTRSISGDGTMLTVDTGNLNITDPWPLTKKTLCILYSYSSSTDVSLLITTENNGSTNITPTVGPGSANATGFYLVDTFDKRPGQKLYIVAVVYGFKLVESDTVHDRIQKTVEDGQPIIVTDEFFESDGFLSYTKTCYIFYRTTIEGPIKAAVAKQYTALTISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AW65</accession>
    <name>A0A0D2AW65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_10029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230946.1">
        <property type="nucleotide sequence ID" value="XM_016384344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AW65"/>
    <dbReference type="GeneID" id="27337112"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10029"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="55"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW10730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="537" mass="57684" checksum="1DA84EE0875F5E88" modified="2015-04-29" version="1">MSSQVHANTKEEVVMVYPQKEDHVEDVERVRTTADEIAELSGIESEATSKAAWLISLCASIGGFLFGYDTGYISAVLVTIGTALGHELSSSEQELVTSLTSGGAFVGAVAAGLTADRFGRRLPIWWACATFVVGTLLQCVAYSLAQFAVGRFVVGLGVGSAAMIVPLYISEIAPAKYRGRMVAFNNTSVTLGQLVASAIGAGCAHFHNGWRLTVGIGGFPPIILAGLLFICPESPRQLVAHGKNDAADAVLLRIYPTSTNEQRESKLKSIELSILQTTDSMTQDSLWMSFKHILNNPPIGRAVLTACTIMAISQLGGFNTLMYYAATLFSIVGWKNPTAVGITVSAANFVFGIITIFLVDRAGRRVLLSISVAGMAICLAIAAIAFHYIPISKDLVVETDKVGWPGIVILVTIICYVGFFSSGVAPIAWVGTELMPLEVRAVGTMLNTATCWGTNIIISSTFLSMMKGITPSGAFGFYCGICSVGWLFIIFFYPECKGMPLEAVREVFSHGFGVRYSKNWQKENRHLRVQSQVAIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AW69</accession>
    <name>A0A0D2AW69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230956.1">
        <property type="nucleotide sequence ID" value="XM_016384354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AW69"/>
    <dbReference type="GeneID" id="27337122"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10039"/>
    <dbReference type="HOGENOM" id="CLU_1229953_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="225" mass="26202" checksum="3303F6F2E295C95D" modified="2015-04-29" version="1">MNGYKTVISNITIDEPLSYPERPFDIDLCEKIYQLPTAFQELALAQRLNTELVTIMASLGKLLRILSEAPSNEEERTFLLTWDPTTHLHQLAGLPSRMKLLKKIVYPSEAIICFALSCFITFLFHLMSTGDLWERKKLNLVLSLSFPMIEDGNDEILDWCRVLALTLCADAKRTRAYTVNRKQLQSWRLFDLEWEEIVSNLRRHFWLPELDEPAKRAWIEARSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZD1</accession>
    <name>A0A0D2AZD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232224.1">
        <property type="nucleotide sequence ID" value="XM_016383601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZD1"/>
    <dbReference type="STRING" id="91928.A0A0D2AZD1"/>
    <dbReference type="GeneID" id="27336365"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09282"/>
    <dbReference type="HOGENOM" id="CLU_037393_1_0_1"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13298">
        <property type="entry name" value="PH1_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13299">
        <property type="entry name" value="PH2_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="60"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="302"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="429" mass="47440" checksum="BC62F7F9A083B7CD" modified="2015-04-29" version="1">MAATSPLRPSTPAKPIFNPPQLSPNRMPPAFVPPSSFQPGHRHLDVFSPVDQNGSFCFDRVIKSGKVFRRVKNKGAWKPSWKPAYLVLRPNLLSVYQNADETDLKASITLSDVNAVAPVRKARTENVFGVFSPSKNYHFQGLSAKDTAEWITQIRLEARTDEDDGLDLSAPQFSHREAEAFNTYESTDMSADEIPSGRISNDDYSAVVQNRPRKGSQLAQRQNAPSTLNEYSGNEQFTTSMSDFSDALGSSLPKNSASSLHKHPALTPIVSSQQLASSSKTKLPPPAGALSSSADAAMDPERVIRHGYLQILKSHKTGVKGWKWLWVVLRAKSLAFYKNDQEYSAVKLLRIGSIINAAEIDPVSKSKKFCFQIILDDKTYRFCASDEDDLEKWLGALKSALSKRHDAERALTKGKGKMALETAISIPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0B5</accession>
    <name>A0A0D2B0B5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histidine acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232366.1">
        <property type="nucleotide sequence ID" value="XM_016383743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0B5"/>
    <dbReference type="STRING" id="91928.A0A0D2B0B5"/>
    <dbReference type="GeneID" id="27336508"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09425"/>
    <dbReference type="HOGENOM" id="CLU_020880_3_1_1"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000065">
        <property type="entry name" value="Similar to histidine acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF12">
        <property type="entry name" value="HISTIDINE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238740" description="Histidine acid phosphatase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="69"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="418"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="50543" checksum="2950D38B52869BC8" modified="2015-04-29" version="1">MTSLTTAAVLVLGSCLAAAFPTPPSSQAPITVQDHTQGYKFDELLHLPGISPYFDAVGFGLEHTAPVGCKVTAASYLIRHAAIYSNDDEYEEYIKPFLYKLEQNRTGWSGPLEFMSTWVSPIPEDKLEQVTPSGKEDAKKVGAHLVKRYPDLAPTVKRVLADKKSRTYDTAEALVQAFPRNPEDIEVVRITQNKNGSMDSLIPHKSCSAFSKEPGTREMAEFVSHYAAHVSGRLAQFTPFELTDNDVVGLQGLCGYESAINGERSPLCAVFTDAEWMSYEYAWDLKYAHMVGPLNPLSPYLGFPWLKAQSELFQQLDGTEGDGSSGWPPEQQLFLSFTHREVPPFVATALGIFNSSSSAVEQFPTDHVNWVRAWRMSDLIPFLGHVGMEKMTCSGRPGRDGEYIRVIANTAPRPIPSCQDGPGASCPLSEWVKIIAAGAEEFKDYAEVCKKEKKENTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1Y1</accession>
    <name>A0A0D2B1Y1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232821.1">
        <property type="nucleotide sequence ID" value="XM_016384198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1Y1"/>
    <dbReference type="GeneID" id="27336966"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09883"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="56"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="450" mass="48627" checksum="BBB6EDC669947B60" modified="2015-04-29" version="1">MSPDTEQYLSDRKISIVSKNDLELSMGGAEGQEPVDGVIVPSLGADHTFPDGGYKAWMTVLGGWLSFIAGIGVLTGFAVFQSYYSTVVLTGYSADDIAWIGSLQTWGCYFFGMWAGRLSDQYGPKVPMAFGSVFMILGTMTASVSTKYYQFILSQGLCSALGIGFAFTPALAVQSQWFLKKRGFVVGMVISGQNVGGVIWAVLVNQLVNYRGVSFGWTLRIIGFMQLALMVAAVLLIQPRFPRGMPREPIRIKTYFTDKRTLLFTLASFVMNLGIYIPYTYVSTYGYQYGLSARMAFYLASILNAGAFFGCYALGFVADAGLGFFDSLIITAFASAIVAFAWIAARAPSGIIVWTAVYGLLSGALQAIFSPCISLLAPSPEVIGTWNGLCITALAFAVLGGGPIGGRLLENAGDTNYVPMQVFTGVCMAVSCCLYSVTRLWVSRDLRKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4P6</accession>
    <name>A0A0D2B4P6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_06679</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234114.1">
        <property type="nucleotide sequence ID" value="XM_016381012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4P6"/>
    <dbReference type="STRING" id="91928.A0A0D2B4P6"/>
    <dbReference type="GeneID" id="27333762"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06679"/>
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        <property type="reaction ID" value="UER00339"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="13"/>
            <end position="281"/>
        </location>
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    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="283"/>
            <end position="441"/>
        </location>
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    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
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        <location>
            <position position="344"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
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        <location>
            <position position="353"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
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        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Fe cation</name>
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        </ligand>
    </feature>
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        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>homogentisate</name>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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        </source>
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            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KIW13898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="449" mass="50221" checksum="F0DC7FCF392F1178" modified="2015-04-29" version="1">MPYTNFEIPEKYTYQTGFLANLETEAIVGALPIGQNSPQKCPYGLYAEKISGTAFTAPRWENQQTWVYRIIPSASHATFAPVSTDNSLETKFNYIPDQLRWDPFDVNADVDWIRGLNVVAGAGDPALKNGVAYYIYGATRSMADKTAFYDADGDMLIVPQQGALDIQTEMGRLLVRPNEICVLPRGIRYRVDLVNEQPIRGYVLEIYNGHFQLPELGPIGSNCLANARDFQIPVAAYSHDTKSEWLVYNKFRGQLFRGRQNHTPFDVVAWEGRYYPYKYDLGRFNTIGTISYDHPDPSLNTVLTATSNAHPGTAIADFVIFPPRWLVAEDTFRPPSYHRNCMSEFMGLIQGSYIAKEGGKGGFQAAGASLHNCMSSHGPDRAAFDKASNEKLVPVKVGVGSMAFMFESCYMVGITDWGLTKCAKRQPNYSEESWGELQDQFCPPPEHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B553</accession>
    <name>A0A0D2B553_9EURO</name>
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        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016380949.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="64209" checksum="5D61F23D818E177A" modified="2015-04-29" version="1">MDGGGDARTVLAVSTMCTNHQQDSAAPENLPSDPFCQKESSRGRWCQRPEWAFKGWYLLLAHMIGSIALALTVALAINGYNAIDTSTPRYFNSKLHLRVADVTTLVSVGLVVVKFFTTSWAAVAIWKCSQISKHDKHSTALRIGHSQLPLMQADRLSLRARYPSRLPREIWSWIIRSIYLCMHFQQFIAPILSGAVNWNPVSVPGSTRKSVNSTDPTSSAVYWQQYPGYSDTAVAVRQQVLAKAQGLANMAWSDSLTLSGNGSSLTGNGCRHVVNNDGLTTNSTLLDSIVPCIRIRNIEWAKSASEVSTSVANDVFSYASSQLSLVNTSLDLFSVNHGQAMLFDPNLLWNSSTTGLPHSTLVSGPQTLTVIISGFGPKSDCTNIPIGIFGNANIPQYLYKWFYNCHAFANVSITAGVTKSAVSAYVSSNVIEDQTPIDQVTFEANLWVQEALWLLPDLMTQLTLANASHIPTWDNLDAYVENVIRQAYLAAWDSLHQTFDDTTVTNSTISTAVSAVSRIQASVSNARVSAWLGVSLMLGGSFLLDALSFSVHDPDGEVSEDIKEEKSDWQEFVRIMVGGIFPSSCSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6R9</accession>
    <name>A0A0D2B6R9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_07362</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234794.1">
        <property type="nucleotide sequence ID" value="XM_016381692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6R9"/>
    <dbReference type="STRING" id="91928.A0A0D2B6R9"/>
    <dbReference type="GeneID" id="27334445"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07362"/>
    <dbReference type="HOGENOM" id="CLU_009923_0_1_1"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="8">
        <location>
            <begin position="407"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="7">
        <location>
            <begin position="537"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="556"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="717" mass="80588" checksum="62411AB9CAE47621" modified="2015-04-29" version="1">MRLTNSAVPVYTVAGASTSRSLPDWLSQKQKRKKDPEFANRVELLQDFEFEEASQCIRISEDGEWAMSTGTYKPQIHTHYLPNLALSWTRHTNTLNKTFLFLSSDYSKTVHLQEDRSIEFHTPGGCHDSLRIPRYGRDLAYDRISTDLLVPAVGVNSNGMGEAFRINLELGRFMNAFEIDVGGDDLNSVGGGALQGGIRTGSVNTATIAESSHNLFAFGTSIGTVEYWDTRSRARVATLAMPSDLDGRPEVTALQFHRSGISTAVGTSSGMIYLYDLRSPVPTLKKDQGYGYPIIYLEYLTATSSTRETVSEPKIASADRRILKLWDERDGTPWTSVEPEVDINCVAWCKDSGMFLTANEGRHQHSFFIPQLGPAPKWCSFLDNVVEEMADDPNDPHAFSRSKVGEVYDNYKFLTSSQLRMLNLDHLVGKTNLLRPYMHGFFVAQGLYEQARLIANPSSWEEERAKRVQEKIDKERESRIRGKKKIAAKVNRKMAERILEREEKNERKRAERVLAQGGDENATLEAAEPEENGLLADSRFAKLFQDEDFAVDETSREFQQLNPSTKIAPASNLDREKGLTAVEEEAIDEIPGSSDDDETDEDQGRNRYRTTDRISSADYKRGSTKKQKKRDQVRMQVSSTSKPSASRSRHDRSFGSRAENARPMERTKRSSGLNGAVGDKVISFDPSTKKPKVPERRASGVSKQDRRSASGNTFRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B707</accession>
    <name>A0A0D2B707_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="10">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="10">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PAN2</name>
        <name evidence="13" type="ORF">PV08_07497</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="10"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234929.1">
        <property type="nucleotide sequence ID" value="XM_016381827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B707"/>
    <dbReference type="STRING" id="91928.A0A0D2B707"/>
    <dbReference type="GeneID" id="27334580"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07497"/>
    <dbReference type="HOGENOM" id="CLU_002369_1_0_1"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000459">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="486"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1098"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1147"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="883"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="885"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="992"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1053"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW14713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1201" mass="132053" checksum="06FA567ABB250D6C" modified="2015-04-29" version="1">MEADWDEITRIAVPSSGLHAIPTPASAVAFDDLQELVWVGNDQGRVTSFYGRDLQRYVSVKAHLGEGPVKQLLVHEKGILSLSASSVHFITRRGLTQWHISHRQMTNLRCMTLTATNNHILVAGSQSTFFIIDVEKGQIVSEHPSEAKYTLMKKCRHVCAATDDGNVHILSLSDYSVIKKWKAHSTAINDMDARNDFLVTCGFSVRQLGVPIVDPLANVYDLKMLTSLPPIPFHAGAAYVRLHPKLQTTGFVASQTGQMQVVDLMNPVNVMLKQANVQFMLGMEIASSGDAVVITDTNGLLYLWGSPSKVRFNNISQKTEFADPVPQQTPHVDWGDSPLNAVGMPYYTEPLLSAWPSHLVFEVGSPPAPVEPSLLFHLQPAEMGHYAPNINPRKLLRHQVADTRASHAPATIAVPKFLSEKAKEGSSDGPGSKLSDAAEALAGVSLSGRAQTDEERMLKYSNVEIKYSRFGVDDFDFRFYNKTPYSGLETHISNSFINSLLQLYRFIPLVRNVAIQHAATSCVAGNCLLCELGFLFDMLEKAKGQNCQATNLLRAFGASREAANLSLFEHLALANGNSLSTTIQAVNRFFLKQVAHDYMTMAGSSTGIDDILASNAFEVIRCMFCNNETTKPASTYVQDLTYPQIDPKHPMRYLRFSSLLKTTIEREAKNRGWCSRCRRYQQLAIRKTVRQLPSALIINTALGNNGAVRTLWETPGWLPSEIGIIVQDRVVYVFEGSDLALHIRNKSPNLVVYELVGFVAEIDSSERSVPHLVSMVNVEVSNPTLDTSHNHKVFPNWHLFNDFLVTPVDPREALHFNQNWKMPSVIAYQVKSAHGKIDQTWKDNLDTTLLYQHYSINGRYPKEECKILTPEEHPQAGTPIALDTEFVELEQAEINVKADGTQETIRPAKSGLARVSVLRGQGEEEGVPFIDDYITIYEPIVDYKTQYSGIRPGDLDPQVSQHNLVPLKVAYKKLWILLNLGCVFVGHGLASDFRKANIHVPKSQTVDTQYLYLAPGKNRRFSLRYLAWAVFREYIQEDVVDDTHADGHDSIEDARMALRLWRKFQEYEDAGIVEQMIDDIYRRGTKYGWKPPPRSIGGTFLFPDANGNGNGNGNGTGAANSAVPSGRNTPDLMSFSSPTSPPSVKTGGSGGGSGSGSGGGGGGGAGAGAPGAAGGGPLKMSVAGISSFVPGNGITRESPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BA31</accession>
    <name>A0A0D2BA31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236069.1">
        <property type="nucleotide sequence ID" value="XM_016380242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BA31"/>
    <dbReference type="STRING" id="91928.A0A0D2BA31"/>
    <dbReference type="GeneID" id="27332986"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05903"/>
    <dbReference type="HOGENOM" id="CLU_492353_0_0_1"/>
    <dbReference type="OrthoDB" id="2118639at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238894" description="Type I phosphodiesterase/nucleotide pyrophosphatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="51535" checksum="0C88F808FACD5D0B" modified="2015-04-29" version="1">MASLSKFVLGVAAALLTVQIRAAPVPEVPYKYVLAFSIDGMHSSDVEKYTAARPGSNITKLLSTGYEYTNAFTSAPSDSFPGSIAQFTGGSPRTTGIWYDDVWDWTYYPPGSNCTGTPGAEVAYAENLDYNSSLLWSGGIDPGNLPQTLVDGKCVSVYPHSRVQVNTAFEVARAAGLQTAYVDKHPSYEIMNGPSGKGLSVGYFPEIQAVPVTVNDTIAYDELHVQAWLSLIEGKAPLNSSGALNTSAMPSLMGGNFQSVSVAQKTVGYNNDSTSSLSPALIHAFDYVDAALGRIRAKLEQKGYLNDTLIIVASKHGQAPINPRLWTEVDPDALVNATGVPVAFATTDDIGLIWLNDTADIPTAVGNLAKNASELDIQTTISGAQLIAQGFGNSAASSRVPHLIVRPKLGTCFTTSKTKLAEHGGLSDDDRKVACFISNPKLQKMTWSQAVNTTQIAPTILKALGLDPNALEAVLSENTPLLPGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BB98</accession>
    <name>A0A0D2BB98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_05935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236101.1">
        <property type="nucleotide sequence ID" value="XM_016380274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BB98"/>
    <dbReference type="STRING" id="91928.A0A0D2BB98"/>
    <dbReference type="GeneID" id="27333018"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05935"/>
    <dbReference type="HOGENOM" id="CLU_032662_0_0_1"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW15885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46908" checksum="115460966F2EE87A" modified="2015-04-29" version="1">MGKYNDITKPAPPLPSPNLRELEPGVSLLWPLSRRGYGPGLIVLTTDTDDPLAIKDGVPSHLVKWAEEGYAVVGIEERAFSSSRASMLLALAVDALAHCEKCDPKGTIGLVAYIPTLWNKIAPAVANAPEVVAAITYANASDVSAGLAWAGEVPLLQQITGTDGPRDSKKQADDSPRPYYYPDIKSYEFATPFSPSFHYNREALSHTRNLTFLKPLMGGPYFDLETIWDEHTYYEFTDRSVEHTMSTMVQEPYVNHVPTMTGGIGRTALTSFYRNNFIFNNSLDTDQELLSRTIGIDRIVDEFLFKFTHDKELDWFLPGVPPTFKRAEVPFHAVVNIRGDRLYHEHINWDQGTALRQLGLMPEYLPYPYPLAEANGSTPASGKQFEYKVPVGGLEIAEKMRERNSVPSNEMMKYQVREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCC4</accession>
    <name>A0A0D2BCC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_03811</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236839.1">
        <property type="nucleotide sequence ID" value="XM_016378162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCC4"/>
    <dbReference type="STRING" id="91928.A0A0D2BCC4"/>
    <dbReference type="GeneID" id="27330894"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03811"/>
    <dbReference type="HOGENOM" id="CLU_026434_5_0_1"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW16623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="521" mass="58972" checksum="CE7A024B12918B12" modified="2015-04-29" version="1">MAKTHSESSEDFEFIETPAAPTPEPPTEDCGVRTTAYPAIKNAPLPADAAGSESFNNYLLIGLLIGVPAYMARQVRGGFYTTIFLAIFTSIPILMAFWTVASSISPRKNEKVRYPGRPVEHYLHFREEEDRAKYHGKNRIPMETFHEMYFDGKVDFKGDCLEMLEYRHDWASWKFTLSLMKFFFTGMIPEVIMHTRSQDEEQVRDHYDRGDDFYSWFLGPRMIYTSGIISDINREETLEELQDNKLAIVCQKVGVQPGDKLLDIGCGWGTLAKYASVNYGAHATGVTLGRNQTAWGNNGLRKAGISEAQSKILCMDYRDIPVPEGGYKRITCLEMAEHVGVRHFSSFLTQVYNMLDDDGVFFFQIAGLRKAWQYEDLIWGLFMNKYIFPGADASTPLGFVIDKLEGTGFEIKAVDTVGVHYSATLWRWYRNWIANQDKVKAKYGERWYRIWEYFLAYSTIISRQGSATCFQITLVKNLNSTHRIEGVPSQFGLDGALKAGLAHLASVKGGMNGGVPVKGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCP7</accession>
    <name>A0A0D2BCP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_03942</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236969.1">
        <property type="nucleotide sequence ID" value="XM_016378292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCP7"/>
    <dbReference type="STRING" id="91928.A0A0D2BCP7"/>
    <dbReference type="GeneID" id="27331025"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03942"/>
    <dbReference type="HOGENOM" id="CLU_007561_2_0_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="198"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="682"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="770"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="817"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="882"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="820"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="914"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="957"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1000"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW16753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1124" mass="123018" checksum="8C461E8B2855AAC3" modified="2015-04-29" version="1">MAPLDKKRPSGEDKGLGPPSSPGTPLQRHFSAEANPFASSAEVVSPPPLQRSRTSSGTALKTPARVIRPDDSWQKHPTRRSSASYTPQATTRSPSFKVWHRRDSLAKLESAGPELPQTFNPDSLPDFLKSFSRRLSKSRGPGNPNPLHTPPHSVKMDRLRPVSVAMTAHYREAVRLAEQQQRAVTEKCKRARQPEPDYTFDELIGKGSFGRVYKGRQTSSNRVVAIKVLDIDEADFRAFGESKDEQIRDFQREIRILRQAQESGAENLNHLIEALPVHSQLWMICEHCPGGSVKTLMRATKDRLPEEKYLIVVARELAKALKGLHEAGIIHRDVKAANVLIHERGHLQLCDFGVANILETSTDKRKTFIGTLHWMAPEAWSENPEYSDEVDVWGYGCTLYECAVGRPPNSDLREHQKLKVRMRRLKESIALPKDQNFSEDLRSLVSSTLTPDVASRPNMVKVLQHEYLKDTEETYPTAILSELVLTYYRWANLGGQRVSLFMPGGAAAASTEDLDNDLESADEWNFSMTEDFERRASAILEIPDFSSETMEGEETPRGPSKASASSPLMTAAQKANFEARVQRGADLSNLFDPNKPAYEYKTKTDFIPIPEQSRRISDLPFRAMAEDRPSSIASNVIDLGDFDESDYAVIPAPKTDDNIQTAYAGTPMKEETIRLADAATLREKRANSKGPRDPVSQSLTARRTSSAEKMPPTTATYDFAASQEEWTVKNRGKAPELQEPAEITSSRPGHATMDWSFASAMSEASIPQINEPETSMGDSTPSRDDTDNTNTAESERRARKHATMEWSFSSAMAEANNTTSNDDYSSDINSNIGSSPPIAPRSATQAAPSALPLPTSRATPTRAPLMRQMTMPVTYGDFAQAEEQEIPRPSTALSEAYSDVSASSTDVDPFGLEREDDEDDHPGPETLDEDVEMGRHYHLRGRSMYSDRGFDSKKSHNSNGNNNPNAAARSSTSHYTSSSTTITATTRNPASTGAGAMPMDSSSATTTPMTANGPGFGLGLGMGVGMGGGMSTIRQRTSVGSASGAATATTGGAGGRLVVDVPPASPPSLGAMGLGASQEQMEAEFIRLLEGMQGTLNAAREVVGGLERRARQQGQVESEWEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCV4</accession>
    <name>A0A0D2BCV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237014.1">
        <property type="nucleotide sequence ID" value="XM_016378337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCV4"/>
    <dbReference type="STRING" id="91928.A0A0D2BCV4"/>
    <dbReference type="GeneID" id="27331071"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03988"/>
    <dbReference type="HOGENOM" id="CLU_003661_0_0_1"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09237">
        <property type="entry name" value="V_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="8">
        <location>
            <begin position="5"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="786"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="727"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="807"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="888"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="950"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="985"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1073" mass="119201" checksum="B3041679BD2625BF" modified="2015-04-29" version="1">MVQAPMLSCPLKQTQEIDWVTPLKNYIRTSYGDDPEKYSEETATLNRLRQDMRGAGNDSASGRDLLYRYYGQLELLDLRFPVDENHIKISFTWYDAFTHTTTSQYSLAFEKASVIFNISAVLSCHAAAQNRSEDKDLKTAYHSFQASAGMFTYINENFLHAPSTDLNRDTVKTLINIMLGQAQEVFLEKQVRDAKKPALLAKLSAQAQFLFGQAKEGLEAESVRGVFDYTWLKFIQIKALHLSSLAEYYQALTEDETNLHGSAIARLQVAEKASKQALSYAKAFPSTPSTSSQLGADTATTLQGITRRQLETVQEKLSSLVKDNDFIYHQTVPAEASLSPVTKVPAAKAIPLSELYQGQDIQRIIGPDLFQKIVPMSVTESASMYDEEKAKLIRSEAEKVEQANGEMAASLDYLKLPDSLNILKGGLDQEMGIDKEFERWCQEVSQQQPFNSAFEHLHRDKQMVLDSLSKSTKQLDMEEGVCEKMRSKYGGEWTQQPSSRLTSTLRADIRSYRDTIDEAGSSDSQLFATARQYESDFEEMRRAAEQGEVDVLYQQALIKAGSSSKGKGKESQEGSLLDEDYGEGGPSVAEQIAKVEDLLRKLSLVKRERMQVLKDLKEKVHTDDISNVLILNKKAIANQETQLFQAELEKFRSHQNRLISTVHKQSSLLKDLTKSYGDLLQDKRVRSDQQKYDVIQKSRNSVLSRYRRVFNAHEDLIQGLVRAQSFYKEMKDSVDSLEKNVESFVSNRRAEGAQLLHQIEQTKNSSASGQAAAEQRRMQELMNRLSMEPKSASPSQTEAPALPPLPSLNASRSSAAISPSYPTPNADPRFTIPPRHSPAPVVPNGYSSQPQPPAKPSNPSPIDSQHAFAQGAATPLSTGYNPMAYPERSTTSTGQHPPTQQSYGYSPVTSPPVGSLNTYISPQSQHPPPQSHTPIQTMNFNAPGGHQYPQHPQFNYPPQTNTPGIPYQSPSPHPQMPQPQSHYQNYQPSPYNIPQNYVPPPPPPGPPGGGSSTQYPPNPSGAWPSGPGGYASYSQPTRYPQQQQAPPPQGHQPPQGQGGGQEPDPWAGLSAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCY8</accession>
    <name>A0A0D2BCY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237049.1">
        <property type="nucleotide sequence ID" value="XM_016378372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCY8"/>
    <dbReference type="STRING" id="91928.A0A0D2BCY8"/>
    <dbReference type="GeneID" id="27331106"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04023"/>
    <dbReference type="HOGENOM" id="CLU_009030_0_2_1"/>
    <dbReference type="OrthoDB" id="5089701at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="79375" checksum="EDCE6CC49ECD675F" modified="2015-04-29" version="1">MRVWCAEPEKCVATASLMFYHDARHASSWIGNVLLQRGPLRSPGPRIPLLTLGVIMQVYLRLALSFVVHDVLTFLSSTEEQRTEQIALILAATRHRSLDELLSQLDDDIELSHGDETLCVGPFGVLRVVSYQDHNNTQATHDGKEGSASAEWDDFMLGDFPVDKSLSGLEVGFLDSPNDAQDMYGNDTGRDLSFLSPLLGDSAVSFFMSPMQSYVPNEADLQLLDLRRTPTPRIQRYLSVDYAPDLMDVDVPTIRLLLARYEERMIPTFAPVQAQGKSAWERVHIPKVNETLGEILVKGNSTDVKCALLFAVLSAASYHLDAVGGGPPHHTMKSWRDMASIFRQRAKTRLLASLRSASLLARSRSAYEEMLLAILSMVTVCVVSGDMVESHAYIHNVEQFIESRRSPHFLKYTSTRMLHSIFLYLWTLQAGVREFGNPGRPQDLVAQNQNLNRRDPTAQSDVWRQLIPVVDETDQNDDEENSPINSNSRSRSSSSGSQSTVTVFEQVYSVSEPLFRLIGRVKSFACAEGTRDDGTIDSSLNDPKKVAEIENAICSWRNDIAPADAGDVHGTNGGGNVRYHFQNAIHSALLVYFYKCVRGIDTYAVQPHVEKTLSHLQLYTEAKRRSSDQSSSICWPGFVAACEALDQDIRHRFAHWFLDETARTGIRMFATAGTAVKRVWHARDRSNNRNLPWSKILQSDNILDQLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE22</accession>
    <name>A0A0D2BE22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_04414</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TYW3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="2"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237439.1">
        <property type="nucleotide sequence ID" value="XM_016378762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE22"/>
    <dbReference type="STRING" id="91928.A0A0D2BE22"/>
    <dbReference type="GeneID" id="27331497"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04414"/>
    <dbReference type="HOGENOM" id="CLU_047426_0_1_1"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="374"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW17223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="434" mass="46842" checksum="20FC3750DD192A96" modified="2015-04-29" version="1">MPQRSLQPPLTVPASFVAKKSQILSLLTRPGDDYSDKSPKGTVDHQIRGLIDEINAYDGLVTTSSCAGRVAVFVEGPKATVTEEPGEEVEDGLGTGKDSKQTTPGPGDSATATTTTTTTTTTSASPGGKGGGSWLYVSHDPIGPLGQVRESDDHSGHASEEPSSSNSPPRGDFTTLFNLTSMSTSNTHSTPLPLPLNNDDDHTRPTLRSKSKSKSPRLIHLTFSPLILHIHCATLRHARPVVAAAINSGFRESGVQSLRVLDDPEHGVMVAVRTAGLAFETVVGVVVSPPDAARSDEDENENANANENAPGGPTGENATSNQPSTSTSTMTMMQSIVSEDYLAMCAGMVNERFRWNEERRERFRTELKRAMAKEGFECGSGSGSTPASSGEPRAWEDKEARRRRKREEGLERSRRKRELPRVEKETWRPESPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEF0</accession>
    <name>A0A0D2BEF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237584.1">
        <property type="nucleotide sequence ID" value="XM_016378907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEF0"/>
    <dbReference type="STRING" id="91928.A0A0D2BEF0"/>
    <dbReference type="GeneID" id="27331645"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04562"/>
    <dbReference type="HOGENOM" id="CLU_042679_2_0_1"/>
    <dbReference type="OrthoDB" id="2125396at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="15"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="394" mass="44100" checksum="03DEC7B1E1D14B61" modified="2015-04-29" version="1">MKVGHGGYRGSEVPLPVEVLNLILSYTSTLQDDETQYTLWACCLVSRSWYAASISHLYAHPLLGNRNFDKFARTICPPVSAHKPKIGLENFITRLDMSGLAYESSKSLTARLLRRTRNSLESFAAPAVTFSIACLAPLSKCAHLKLLDLSCDSYEMTLPQLLDSIGHLSHLVTLKLPRNALRGRCSLSSKSHWPVHLRNLQVSDFLYDDLESWATLFESWPSSIRSFKIAECKGYGSLHCLEPSFLAVDSITSFEIGISWHEDAFPFHRLLKTFPNIVRLTLPAYQAEQLAKSTGVDEFMSDLQSGAYLQDADHESSVEVLILTGQQPPATVPPALSAEILGRYVHKFPRLRRLEIPEPYARPGGATREYELLNDELERRGNAENRATSGLYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF92</accession>
    <name>A0A0D2BF92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_04481</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237506.1">
        <property type="nucleotide sequence ID" value="XM_016378829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BF92"/>
    <dbReference type="STRING" id="91928.A0A0D2BF92"/>
    <dbReference type="GeneID" id="27331564"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04481"/>
    <dbReference type="HOGENOM" id="CLU_072095_0_0_1"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="10">
        <location>
            <begin position="126"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW17290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="274" mass="29600" checksum="E3B84A5D5887391C" modified="2015-04-29" version="1">MADVQTPTEASLFSTSTPTPEYTAPVSKEASTQASLAASTTQPAATQTTVTMNGDSTTPASISKSTGTMTNGVVAEPTPTTTSTSLQQQQQQQQQPSENVPTDEEPPLFSPSLISPVVSSLLPQGYTIRPLRRSDYYGGFLDTLRVLTAVGEPTLAEFNARYDFMYSRNDTYYILVICDGSGTVVGTGAVMVERKFIHNMGLVGHIEDIAVAKNQQGKKLGLRIIQALDYVAENVGCYKCILDCSEANEGFYVKCGFKRAGLEMAHYYETAPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFE9</accession>
    <name>A0A0D2BFE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237944.1">
        <property type="nucleotide sequence ID" value="XM_016379267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFE9"/>
    <dbReference type="STRING" id="91928.A0A0D2BFE9"/>
    <dbReference type="GeneID" id="27332006"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04923"/>
    <dbReference type="HOGENOM" id="CLU_490037_0_0_1"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="566" mass="63376" checksum="78A72F6AA58D830E" modified="2015-04-29" version="1">MDAVLDLLKCSICPKQPSFSDVSHLLTHVSSKGHLSHLHKLQVRSHQEVEAGLLLINYNKWYDHHGLAGLLSERMVLKQAKKAGRKKTAAEQGAYVTETGATAQPPQDQVMQLRRGEGSRSQRQKRSVRTRRSRPILDNDSDFEYSPVKRYGFGPPQALCMHTLTKSSRSKPRRPHVVSPVNHNIYNNDDSTAPRGHQPLATPEHSKLKGTIWPGMDLFDAATEEMKRKRNQKKDGSVVRHMQRLAALVEPTEVVYSPSGNMMKARHIDDLEDTSSLIDGESPIPKTKQVRPRKRQPLKEKDTNAPRLVKRKSRNTPLKKRARQALDQSIPPLPYLPSSSTGESYTLGPGFLQMEDDEEDWKPMVGNGSRKKRSSQFTIFDDGSPGYGPATPADQRRNPFQVPPPPYLNSERPQLPTISASWLQPQHQAGAQYAGLYSVCRPMSRDSQDFYDTGRGKENALPFAGLQSDYRTMTTNPLSWKSPVRDGITLPNPPGSPLSNIFGVFPLEALHEDPFVSTKNPLADALEHFEEEMRSTDTKVPPSLLQNTTDDEDTKPQIHALAAISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFR4</accession>
    <name>A0A0D2BFR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards urm1 and mocs2a. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237656.1">
        <property type="nucleotide sequence ID" value="XM_016378979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFR4"/>
    <dbReference type="STRING" id="91928.A0A0D2BFR4"/>
    <dbReference type="GeneID" id="27331717"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04634"/>
    <dbReference type="HOGENOM" id="CLU_013325_1_2_1"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="520"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="660"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="715" mass="76369" checksum="DF0D2AD4BDEF0243" modified="2015-04-29" version="1">MSVDTSPQHQARSTATTTTTHPSLVPAPPLASSRYNRQLLVPQFGLSGQTRLLASRVLIVGLGGLGCPAALYLAGAGVGTLGLMDGDTVEQGNLHRQVAHTEEAAAAGASKVRSALDRCTAINSEVRYVCHETRAAASEAFLDAVARYDLVLDCTDNPATRYLISDACVVAGKVLVSGAAQRGEGSLVVLNCPPLDLSLPASSAASSSSGGTRDAGPGVAATTPTTTTTTTTTTTSVEKGPCYRCVFPRPPPPEMVRGCSEIGILGPVVGVIGTLMAGEAIKIIARGDVDPQRRGRGRSQDTTYTKGSTQTRTQTQAHPPPPPPPPPPPTPPTPPTPPTPQQQQKQKQQHTMLLYNTYATDPRNMFRTITLRGRRKDCLVCGDDEVLAGKKLSRITAGTIAEGRLDYQGFCGVAEDVKILEESKRIEPGRFLEEEMGRRRRRTRTRNKTNETSKGDKGEEKEGTAAGAGSGAASGGTVLVVDVREEHEFELGTKVKGSVNIPISKILRVGALEAVEELRHHLHSRSTPSSSRLHQHPHSHVSVSVSDTTTLDRLSTTSRDAGDAGEGMRDLGGTVDSEDHVPITRYGESDFPTAPSQGPGAFAQRSEDGDESEDGKADRKERDEREGGGEDTSTIPVYFVCQRGNDSQIAAQKMIEAIEREREREKSQAATTTTETQAETETPQKEETKKMMGSKWGWVGDVKGGLMAMERIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIW1</accession>
    <name>A0A0D2BIW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
            <ecNumber evidence="8">1.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_10599</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="EC" id="1.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21817"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.3" evidence="8"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231515.1">
        <property type="nucleotide sequence ID" value="XM_016384913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIW1"/>
    <dbReference type="STRING" id="91928.A0A0D2BIW1"/>
    <dbReference type="GeneID" id="27337682"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10599"/>
    <dbReference type="HOGENOM" id="CLU_034311_1_0_1"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000018">
        <property type="entry name" value="D-amino acid oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW11299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="362" mass="38778" checksum="58D08FD642D9483C" modified="2015-04-29" version="1">MAQKNVVVVGAGVAGLTTALLLSRKPGYKIVVAAKHMPGDYDIEYASPWAGANYMPVSVRGTDAAEWDKATWGPLEDLARNHPDAGVHFQECEIYSRKKDLGTATATWFAELLSPNPWFKDVVPSFRVLPKESLPSGVDSGTVFTSVCINTAIYLPWLVSQCLKNGVVFKRAVFKHISHAALPDVHPSKKVDLVVNCTGLMACRLGGVEDKSVVPARGQIVVVRNDAGKMVDVSGTDDGEDEAGYMMTRAAGGGTILGGCYQKGNWDSQVDPSLAVRIMKRAVQLNPALTGGKGIEHLDIVRHGVGLRPVREGGTRIEKEKIGGTWVVHNYGAGGAGYQSSYGCAEAAVKLVEEALQPRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJB3</accession>
    <name>A0A0D2BJB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="1">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_02969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="1"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238896.1">
        <property type="nucleotide sequence ID" value="XM_016377326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJB3"/>
    <dbReference type="STRING" id="91928.A0A0D2BJB3"/>
    <dbReference type="GeneID" id="27330052"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02969"/>
    <dbReference type="HOGENOM" id="CLU_042529_5_0_1"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF7">
        <property type="entry name" value="SLL1159 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="46"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW18680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="218" mass="23800" checksum="0DECF42CC9B5BE1E" modified="2015-04-29" version="1">MTTGTLQGQLDQIVEHFKAVAPESVRSVIFKATDDFAASFDPKSTIQVGDTLPAFSLTDAVGKQVRSADLLAKGRGIVVTFYRGEWCPFCNLALAALQKRLADFEARGVTLVAVTPELPTSALSTVEKNELKFAVLSDVGNKYAAELGIVWVQPDSLREPFAKFGHDLEKRNGDDSFAVPIPATLLVNSSGKVRNTFIDPDYKKRVEPSQVLEWIDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLU3</accession>
    <name>A0A0D2BLU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240134.1">
        <property type="nucleotide sequence ID" value="XM_016374858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLU3"/>
    <dbReference type="STRING" id="91928.A0A0D2BLU3"/>
    <dbReference type="GeneID" id="27327576"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00493"/>
    <dbReference type="HOGENOM" id="CLU_1069716_0_0_1"/>
    <dbReference type="OrthoDB" id="4114413at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="278" mass="31380" checksum="B3AA19B9F802B07C" modified="2015-04-29" version="1">MPAASPTTYLSLSNAIPCTGYPAHIQAQQMRTIRYPEYQVRPLLSEVEESPVAAAYTSFREWACRQIDSGASRESILGPEKVEVDLFFRARGPADPHTVSTWACEFFRALEGIDVFVCLAGIFNFDRFMRWMIVPSAETYAKVPPGQRPTACQRLVPHHPASDLPVLPELRDALIYDMRDFILASQCYGTTINWDGSLDEAIDIDPETANMTISDAFAEHSWHMDNWTFSRGFAAVFPELRHRYRISPAIAIPPSPGNVEELLQKRDRIRTGIKREGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM24</accession>
    <name>A0A0D2BM24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232455.1">
        <property type="nucleotide sequence ID" value="XM_016383832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM24"/>
    <dbReference type="STRING" id="91928.A0A0D2BM24"/>
    <dbReference type="GeneID" id="27336598"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09515"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="246" mass="25374" checksum="A5829D0ED982EC35" modified="2015-04-29" version="1">MSVANKVIIVTGAGSGIGRATALLLGAEKAKVALFDIDSSIFDVEAEIKASGGSALAIKVDVSSSEEVNSATKAVVDAFGPIDGGANLAGISGGGTVNLEQETDEDWDRVIRINLGGVKNALRAQLQHRNPKGASIVNASSIGARIGSPGNAAYSASKAAVSGLTKSVAREMGPHGVRVNAIAPGITDTPMVGRVPESIRDEWRKANVLGRLADPVEMANVILFLLSDKSSFITSSVCYLARLHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM52</accession>
    <name>A0A0D2BM52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Core protein II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_09545</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232485.1">
        <property type="nucleotide sequence ID" value="XM_016383862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM52"/>
    <dbReference type="STRING" id="91928.A0A0D2BM52"/>
    <dbReference type="GeneID" id="27336628"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09545"/>
    <dbReference type="HOGENOM" id="CLU_009902_0_1_1"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="53"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="201"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW12269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="461" mass="48877" checksum="8FCCF55E5FE9036D" modified="2015-04-29" version="1">MASPASLGSRALRASRRQFPVPVLQRRGLAAAASGSFGYETGEANGVKYASRDLPGPTTTLTVVAKAGTRYQPLPGLTDALEKFAFKSTSKRSALRITRETELLGGETSAYHSRENLVLRTKFLRDDLPYFTELLGEVISKTRYTTHELEEEVFHVMKLAQKGHLASPSSLALNSAYGVAFHRGLGEPLYPTSSTPITKYLDAETIWEFSGAAYAKNNIAVVANGASHSELGKWVKEFFGDISEGSSKFKIESQPSKYFGGEERIAHSSGNAMILGFPGSSSFTTASSYKPELAVLAALLGGESSIKWSPGFSLLSKAAKDLPGAQVSTQHEAWSDAGLLYVTISGNAQQVAKASKEVVDAIKKVASGEIAEEDIKKATALAKFRALEAGQLTQPGLEATGTGLILSGKPFQIDEIGAAIDKVSSDKVKAAAKSLLDSKASVSAVGDLFVLPFASDIGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN34</accession>
    <name>A0A0D2BN34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240181.1">
        <property type="nucleotide sequence ID" value="XM_016374905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN34"/>
    <dbReference type="GeneID" id="27327623"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00540"/>
    <dbReference type="HOGENOM" id="CLU_1677652_0_0_1"/>
    <dbReference type="OrthoDB" id="4127469at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011431">
        <property type="entry name" value="Trafficking_Pga2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07543">
        <property type="entry name" value="PGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="159" mass="18315" checksum="ACCC6E0F5EA26763" modified="2015-04-29" version="1">MVEYIPPPEDFSHLNAVQRYMQKGQLDRQDYIWLFIIVLAYFTARPYIQKFFKWWMGSEEQKEGEQVMTEYFQSKAKVGPNAIRGTESEEPSLIPEKPGDASASGRNVDQKGGVVNRKAKGKSGEEQLLDWDDEPARHPTEGDKNDVVAWMDKWTNDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNA9</accession>
    <name>A0A0D2BNA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240221.1">
        <property type="nucleotide sequence ID" value="XM_016374945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNA9"/>
    <dbReference type="STRING" id="91928.A0A0D2BNA9"/>
    <dbReference type="GeneID" id="27327663"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00580"/>
    <dbReference type="HOGENOM" id="CLU_089354_0_0_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="298" mass="32844" checksum="AB2823FCD557B085" modified="2015-04-29" version="1">MYIPNQQTIELSWPLTRDESPEPVSFTFASRAAVSSTNSTTNVDDLNPPNYNGTATAFIAVSITVLIFLALIISYVVYRKIRSGEDDSDNESSTSDSAWRVEAEYGSPSSSIAAKHRKRIKKLEQVAPSQTLRHWRSDKEEHHVKTFATISTKLICAICLDVIQDSDTIRELQCCHVYHTNCLNLWVERAHHDCPLCKYDILGAHQDPQKVRAAGQAVPEGGDSHSEHLEGPREHPAVTASRELQTRIQQANVPSPARPTATAEVAAEPPTADNNDTEETQPSVHGANAEESSGRQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP14</accession>
    <name>A0A0D2BP14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spindle pole body-associated protein cut12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240869.1">
        <property type="nucleotide sequence ID" value="XM_016375593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP14"/>
    <dbReference type="STRING" id="91928.A0A0D2BP14"/>
    <dbReference type="GeneID" id="27328313"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01230"/>
    <dbReference type="HOGENOM" id="CLU_589258_0_0_1"/>
    <dbReference type="OrthoDB" id="5383703at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="55399" checksum="678A3622035FDDC3" modified="2015-04-29" version="1">MPIDETVLDPPVTPAPVFAYRALKGVFFGSPESSPENVYHNNKENITPVLSLSPSPSKRKLALDAALHLTPSTKRTKRDSGGAILSPTKGILRTPGLATPRTKALRDVNVKFKSVSPEEVAQRRNHRLKMEGPRQVDKDKKEETQAPAVKNDNASLNNGGLVCASTTNTAGTAAVSTFTPCAIEAYIAQTEKEMKKLVKYGQKMREYARKKDAENLELKGMIEVLKRENERLRRSSDVGLGQTHQQTENKQKQQQHHHHSESDTNGHGGQRVESVAEDKAKRAQGYVREEVGRVEARSQSVRLHSHQSLAHRRKEEPPRVGTGTGTGTGTTGSMSTQRRTTRSVSSSSTKRHQVVQGTTVHDEFGRPSTIASSLAPAPVPAPAKMDEGGNEHRTSLPLRSPSGSMAIRGTKGTFDREIGTGSTRLPPDRLAAARERLRRRAEAKKASAEMNAGDHDQSHVKAHGQREGVLIDNGEDDVGPPQLPRPASFGPGRRESHEQSLVDWVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPE2</accession>
    <name>A0A0D2BPE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241024.1">
        <property type="nucleotide sequence ID" value="XM_016375748.1"/>
    </dbReference>
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    <dbReference type="STRING" id="91928.A0A0D2BPE2"/>
    <dbReference type="GeneID" id="27328469"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01386"/>
    <dbReference type="HOGENOM" id="CLU_011522_0_0_1"/>
    <dbReference type="OrthoDB" id="5294180at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF12">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="673"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="724" mass="79740" checksum="F982263F6F1CF9BC" modified="2015-04-29" version="1">MAPAKERKAAPIAKASPSASTKSSKMHRRSRSGCFTCRLRRKKCDEAKPKCKACRNLGLDCEYKRPHWWINNENRRQQKEHIKTVIKRTKTNEKNVAAQSACMSLPLLVCIQLEADSTADGTRGSSDDSPEDYDPNFDPSFATTPGIFTPFGPEVYMTHDPYSQGFPWEVDVKTEMHTYVNDELTRRDSSISTFSTWVPPPPHAMLPSYTGDDFTQPELYEQRQDSWSAEDPVSFNVFDFNHLGRQSGPQCSMIQLDDCDRPLFNHLLDNVLPLLFPVLEANQPGSVRADAVLPALENNKAYLHSCLLAAATHMKDTRTSLGSMVDDETMRHRLAFVTIVVDALNSDTHHSEILDALLGMISLQGCVGSSSNPEKELIPWHQHFQTAADIVQKLELPAILEGLHVTGGHPAFNMTLTAWIDILGATMLGKAPRFSNTYRNMFFAQATSGLEDLMGCNDLVMYLLSEVACLDSLKTDGRLDDIAICSHITSLAQTLDQIEPAEGPQIPYSKSGVLKPKQLTKNITAIFRKATRVYLCSLVPEYNRHQPATVNLISQMSDLMQFIPSGPNGFDRSLVWPLLICGVNSIPASPFRRMLADRCEMLGEAADHGSFGRMVHLLHEVWRCNDDMILSAGVCEATPVTAGSPGGSISTPIAASATTSGINIAPAPAPGLSMSTTTATNPAAPLSSSSMTTTTTTTATTVPRNQNVHWRDVMRQIGWEFLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQE7</accession>
    <name>A0A0D2BQE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241404.1">
        <property type="nucleotide sequence ID" value="XM_016376128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQE7"/>
    <dbReference type="STRING" id="91928.A0A0D2BQE7"/>
    <dbReference type="GeneID" id="27328851"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01768"/>
    <dbReference type="HOGENOM" id="CLU_045277_7_2_1"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW21188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="188" mass="20404" checksum="5FEF6D1E2E6EB542" modified="2015-04-29" version="1">MPYNNAPIEPPEEITGTSVLPLARVKKIIAMDDDIAQCSTTAAFAISVATENFIRYLAEQSYNVVKSERKPRKTLAYKDIATAISRIDNLEFLSDTVPKTKTYRQFREEKAQEAAAKAASAAGATSNAANGDSSTLSIDTMMKNQSLNGTNGVNGSAHNITGSPIAHRSAHSRNHSHHDPIRDIEMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR23</accession>
    <name>A0A0D2BR23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein Ras-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241116.1">
        <property type="nucleotide sequence ID" value="XM_016375840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR23"/>
    <dbReference type="STRING" id="91928.A0A0D2BR23"/>
    <dbReference type="GeneID" id="27328562"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01479"/>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000654">
        <property type="entry name" value="Small g-protein ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="242" mass="27336" checksum="C3D243FBED765F00" modified="2015-04-29" version="1">MAGKMTLYKLVVLGDGGVGKTALTIQLCLNHFVETYDPTIEDSYRKQVVIDQQACMLEVLDTAGQEEYTALRDQWIRDGEGFILVYSITSRNSFNRIQKFHSQVQRVKESGHPNSPTGASYLPTQMNGTPTYTGPVPIMLIGNKSDKHHEREVSSQEGQALAKELGCDFVEASAKNCINVEKAFYDVVRQLRRQRQSPMKQIDRKGTNYGPAPAMRNNFDAEHPRIYREHGRRRGANKCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BU38</accession>
    <name>A0A0D2BU38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235015.1">
        <property type="nucleotide sequence ID" value="XM_016381913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BU38"/>
    <dbReference type="STRING" id="91928.A0A0D2BU38"/>
    <dbReference type="GeneID" id="27334667"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07584"/>
    <dbReference type="HOGENOM" id="CLU_605706_0_0_1"/>
    <dbReference type="OrthoDB" id="4334750at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="398" mass="46114" checksum="5EEA1E9D666D0877" modified="2015-04-29" version="1">MPSERASFVPRERRRPMVPEPFPSISVSRQSVSFLLEPMARRWCKFCPILDIPLYRDQLNEAKQQELDKSASALSLRAIGNTLYKASEFCWEVDAWRFVFNSISDDKRLRIDKRPYEFIVKDEHDNVSVEQRIPDATMGLRSYDDFDITHGFNCHVTDCTEDHSGMQPDRTLLQDRLVAQMINHEGGLIVDGVWGKTDILFPFAVYEAKKGATIEQARDQIYHACRVYLAMLDDLARNPANVSEYQSRESKKYQLFAFLSCGAYWEVFVAWHFLNECFVETIWTGNIKEFSRAYDLICIVNQIHAYAISEHRSFVIKHLEPWLSRAESFRGAQMDLSPLPSGEDSVESLESSPKWFVIKGASRRALSAKRAATRMRKRRREELETDASDEQTSRRQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWE3</accession>
    <name>A0A0D2BWE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235785.1">
        <property type="nucleotide sequence ID" value="XM_016379958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWE3"/>
    <dbReference type="STRING" id="91928.A0A0D2BWE3"/>
    <dbReference type="GeneID" id="27332700"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05617"/>
    <dbReference type="HOGENOM" id="CLU_059606_2_1_1"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="111"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW15569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="293" mass="32428" checksum="68974AE616F6C90D" modified="2015-04-29" version="1">MANRGYDVVVDVDAEGDLGHTDLQDDDLEFHPSNFENNPSSRKIQPDSTSFLANSATNPATRPNDPSAVPSKHMLWSLSFYAQFFDVDTSTVLQRCRRALLPFLPNQPPFIETLEGNPDLYGPFWIATTVVVILFLTGTISHKLASEGRKHFEYDFRLLSGAAALIYSYTAFVPLGLWGALRWFGAQSLDLVECWALYGYGNLFWIAVALVSWSPLNGLNYALVGLGYAVSVFFLVKNLYPVIAATDKKISQILLVVVVALHAGLAIAIKILFFSHKSPATDGDDKRFAQFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXD3</accession>
    <name>A0A0D2BXD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236160.1">
        <property type="nucleotide sequence ID" value="XM_016380333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BXD3"/>
    <dbReference type="STRING" id="91928.A0A0D2BXD3"/>
    <dbReference type="GeneID" id="27333077"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05994"/>
    <dbReference type="HOGENOM" id="CLU_007383_12_1_1"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="348" mass="38152" checksum="A092B38CA188E132" modified="2015-04-29" version="1">MSTSGKNVFLIGPGFIGRNVVDILLSEEYTVTTLVRRESYGAELQKDGINTILGTLEDSDTITAQTVASDIVIHTATADHLPSVEAVLKGVRARADQNKQTIFIHTSGTSLLGDDSKGQYKGDKVFSDDAPQDIDALPDTAAHREIDLAILKARNDLGAKAKLVIMIPPLIYGVNEKYKRLSIQLPTLTRFALKHGYAGQVGAGASVWSTVHVLDLARAYVTLLHWLEKTDAHEVLKNPYFFCENGEEYPWGEFVRTIGSTLHKAGRIQDPNPRTISESEYNDLFGPFTAWVVGSNSRSRAKRLRELGWEPREKDVLASLAEDEIPIILEEKGEFSGYAGVAASGKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZA1</accession>
    <name>A0A0D2BZA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA/RNA-binding protein Kin17 WH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236855.1">
        <property type="nucleotide sequence ID" value="XM_016378178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZA1"/>
    <dbReference type="STRING" id="91928.A0A0D2BZA1"/>
    <dbReference type="GeneID" id="27330910"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03827"/>
    <dbReference type="HOGENOM" id="CLU_030065_0_1_1"/>
    <dbReference type="OrthoDB" id="10266249at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Kin17 WH-like" evidence="6">
        <location>
            <begin position="52"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="372" mass="42052" checksum="72A3E950D17AA949" modified="2015-04-29" version="1">MPRAEVGSTKYIANQMKSKGLQRLRWYCQACQRQMRDENGFKCHVASESHIRQMQIIGEDPKKAINDYSRQFLRDFIQLLRTGHGEKKVNVNHFYQEYISNKSHVHMNATKWPSLTEFAKYLGREGICRVDEDEQNENKTGASALTISWIDNSPEALRRQEALKKKERQDRGDEEREQRMIQEQIRKAKREGRQHSSEEEDEEEIEEAEQVEGEGIKRKDGEKIVLNFGSRKSPVEGQQPPTPPLSDKDEASSDQEKATATQSASDSAPANRQAPASEEPTHVDNTSGKTAAPAKQPVSLSFGSSTARPKNVFATASKKNALAGPKKPTMLAPSRPMSEAERIMKEEMERKRHREAGGFKAGANAFKKQRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZL7</accession>
    <name>A0A0D2BZL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237010.1">
        <property type="nucleotide sequence ID" value="XM_016378333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZL7"/>
    <dbReference type="STRING" id="91928.A0A0D2BZL7"/>
    <dbReference type="GeneID" id="27331067"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03984"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12163">
        <property type="entry name" value="2-Hacid_dh_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="125"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="224"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="360" mass="40348" checksum="1064BC3C38E33758" modified="2015-04-29" version="1">MGSIEKANGLAQDTILIISPGDPRQEIIDGIQSRHPGVKIHWNSMKETPLTVEDIPQNIWDTVTILWGFHVPADAVMPNLRFVQLSSAGADHWASNPHYQDPNTVFCTSNGAHPPQIAEWVIGSWLSHQHQFLKYSNYMKEGYWEPLFQTTFQDSWGLRMGILGYGAIGRQCANLAKALGMDVVAYTARERPTPESRKDDSYCVPGTGDPDGLIPSKWFHGTTQESVNHFLDQDLDIVVICLPLTASTRNMISRQQFEILAKKKTFLSNIARGGHVNTEDLIEALEKGMIRGAAVDVTNPEPLPKEHPLWKAPNLLITPHVSWSSTNHWSRVYAIFEHNLGVLAGNKGNFVNKVDKQRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0D0</accession>
    <name>A0A0D2C0D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237265.1">
        <property type="nucleotide sequence ID" value="XM_016378588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0D0"/>
    <dbReference type="STRING" id="91928.A0A0D2C0D0"/>
    <dbReference type="GeneID" id="27331323"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04240"/>
    <dbReference type="HOGENOM" id="CLU_495246_0_0_1"/>
    <dbReference type="OrthoDB" id="4161734at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="61"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="550" mass="62943" checksum="A6A7B5BA0D3D0FBC" modified="2015-04-29" version="1">MAEVQLPAAESQAFQINLDQWPEYDGYTGLGDREIRVIDVEAGDPPMCRIRHVSLDEKPHYHALSYYWGAPVTPENLKAVELNGSRVFVRPNIYSFIWHMSRYYQAVTVWLDVLSINQRDAEERNRQVSLMGSIFTSAARVYAWLGEGDADSDYAFDYINSSNPKKETVYSRPILSACFEQLAMRPYWTRIWVLQEIALATSVLIMCGTKLSHWDDFSRSIEGDVAERAPHCLQVMNLRNRGCKDRHLLELMETFKSARCIDPRDKAYGVRALATNGHCLDIDYSESVGSLFFRIASLYPDTAFLSWMDLRVIERSSKSLLGSLSLSQRDLVVGLAGSKADRFRYWTEIYGRVETVYELHQVDDTGISVLPATRLEVKLSLGRRKRNPVWYLYGGPNILPGDLVCSFISWDLGQNSLMLVIRPGKPGIMGIATFHVAPHAEDPYTLHFQRLQTRLVNGVTVCRGDGRKVDGSWHQTFHINRLVWSLILANQTRNLDIWAADVDPRLQRRPVCDCQHKTSLWEKWGREAEEEDSEEEGTSEEDTEEFLFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0Q9</accession>
    <name>A0A0D2C0Q9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_04455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237480.1">
        <property type="nucleotide sequence ID" value="XM_016378803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0Q9"/>
    <dbReference type="GeneID" id="27331538"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04455"/>
    <dbReference type="HOGENOM" id="CLU_2654513_0_0_1"/>
    <dbReference type="OrthoDB" id="10480773at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW17264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="76" mass="8662" checksum="CEBEEB0F62B9F0F5" modified="2015-04-29" version="1">MYYSPPSRSSSQSSLDSIQTVPVQLLDARFVDSDKLRPRLNKIFEGQNYGLERSHGQWRILDAPPLSQQNKSSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C2D4</accession>
    <name>A0A0D2C2D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ZIP zinc/iron transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238025.1">
        <property type="nucleotide sequence ID" value="XM_016379348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C2D4"/>
    <dbReference type="STRING" id="91928.A0A0D2C2D4"/>
    <dbReference type="GeneID" id="27332087"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05004"/>
    <dbReference type="HOGENOM" id="CLU_027089_0_2_1"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40362" checksum="1147BA07A6809654" modified="2015-04-29" version="1">MASLGSFASLVTRQEEADTTPTCDTGNEYDGRMGLRVAALFIIWVTSTIGASFPIFANRHKGLKVPDWVFFICKYFGSGVIVATAFIHLLAPAEDALRNECLTGPITDYTWVEGIILMTIFVLFFVELMVMRYGNFGQPHSHGHAHGHSDTDTELTAATQENYKDNPSAESAPARTLSATLGEDHLGHTREHNDIEEANNPLSLEDYKTQMTAIFILEFGIIFHSVFIGLTLAVAGSEFDTLFIVIIFHQMFEGLGLGSRLAVTPWPKDRKWTPYLLAVGYGLSTPLALGIGLGVRKTYPPESATTLIVNGVFDSISAGILIYTGLVELMAHEFMFSPSMRKASIKTVLSAFFTMCLGAGLMALLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C4N1</accession>
    <name>A0A0D2C4N1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_02812</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238740.1">
        <property type="nucleotide sequence ID" value="XM_016377170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C4N1"/>
    <dbReference type="STRING" id="91928.A0A0D2C4N1"/>
    <dbReference type="GeneID" id="27329895"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02812"/>
    <dbReference type="HOGENOM" id="CLU_005015_1_1_1"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000118">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="13">
        <location>
            <begin position="23"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="11">
        <location>
            <begin position="206"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="12">
        <location>
            <begin position="692"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW18524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="858" mass="98186" checksum="19D3882F6CB2C3DE" modified="2015-04-29" version="1">MGDISKPLDSPSDMEVIDLSTGWSFKQTDDIEEKAWNPVKKIPSTVHQDLINCGRLKDPFIGFNETRAEWVGLKSWTYRTTFASPGVSPETKVVLAFDGLDTFAHVRLNGKLILESDNMFLSHRIDVTEAIRARSNNILEIEFDSAFLKAREIRAQHPKHKFLCFNDPPDRLAVRKAQCHWGWDWGPILMCAGIWRPARLEMYHARVSDLRLDVGVSDDYHFATIDATAEIESNSRTVPQLHAQFHVMLDGKLVSATNCVADKDGKASIKLPILRPELWMPNGYGKQSLYTVSVTIASDNIPLHTTSRRVGLRKIELVQDDDAHGKSFYFRVNGVDIFCGGSCWIPADSFLTNVTPERYRAWIELMVPANQKMIRVWGGGIYEDDSFYDACDELGILVWQDYMFACGNYPCFPAILKSIEAEVIANVRRLRHHPCLAIFAGNNEDYQVQESFNLTYDYDDKNEENWLKSDFPARYIYESLLPRLSKAEAPWIPYWPGSPWSHGKKSIDPTVGDMHQWNVWHGKQEKYQIFDSLGGRFNSEFGMEAFPHIATIRSFVEKDEDLYPQSHVLDFHNKADGHERRIATYLVENVRTCTDLEAYIHLTQLIQCEALMFGYRGWRKQWGDGRHCGGALVWQLNDCWPTTSWSIVDYYLRRKPAYYAMARVLAPVAIGIRRAHYDWSITHAREPETQAWELWVVSSHRTEITADVEVRFVSVRTGREIKPKFVKQAIRIGSNSTTHVSDGEIDNVHQEPHILAARIWVNGELVGRDTDWPQPLKYLQFPERNVKVNHVGDEMHITADRPVKCLVFEEREGCHLSDSAIDLVPNDKQIVKVRGLRAGDPPLNWTYLGAGEQGTPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C502</accession>
    <name>A0A0D2C502_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02963</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016377320.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:PV08_02963"/>
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    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="RRM2_NGR1_NAM8_like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="63"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="156"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="291"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="403" mass="43064" checksum="584C7C2B9A09DACA" modified="2015-04-29" version="1">MSFEGYGQFPNAQQDGAPGSVPPQPDGAAPGQPTDPSAQQQIGFQPPNVSGTPQSGPGAEGKTTLWMGELEPWVDENFIRNLWFQMGEQVSVKMIRDKFSGSNAGYCFVDFSTPQAAAKALQLSGQPMPNSNRPFKLNWASGGGLADRRDDRGPEYSIFVGDLGPEVNEYVLVSLFQSRFPSCKSAKIMTDPLSGMSRGYGFVRFSDESDQQRALTEMQGVYCGNRPMRISTATPKNKGGPMGGGGGGGMGMPGAGAGPMGYPPMGGPPMPYYGGQQSIQPMNQFTDPNNTTVFVGGLSGYVTEDELRSFFQGFGEITYVKIPPGKGCGFVQFVQRHAAEMAINQMQGYPIGNSRVRLSWGRSQNNSGPAGTPYRPAPPPPIYPSMGMPPAHSYGNYAPMKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C5E5</accession>
    <name>A0A0D2C5E5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239030.1">
        <property type="nucleotide sequence ID" value="XM_016377460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C5E5"/>
    <dbReference type="GeneID" id="27330186"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03103"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF155">
        <property type="entry name" value="EFFLUX PUMP AFOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="60"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="583" mass="62906" checksum="755B7002AE81858C" modified="2015-04-29" version="1">MLADGDPESQLQREVGATQNTELSRVVPPEQVGTAENSVPSDDEAAPKREYVTGIKKAMILGPITLTYFLFFLDLAVLSTATPAITSRFNSLVDVGWYGGAYQLGSSAFQPLTGKIFRYFSIKWSYLTFFLIFEIGSLLCGAAQSSSMFIVGRTIAGVGSSGIANGSLTIISAILPPREQAKFLGLNMGLGQLGLALGPIVGGLFTEYVSWRWCFYINLPVGGVVAILLLFLRIPEPEAKLPPRQVLATAIKSLDLPGFMLICPAVVMFLLALQWGGNQHAWNSSIVIGLLVGGGVTFALFLVWEQRQGDEAMVPFAMLKHRIIWSASGNMFFLLSTILVADFYLAIYFQAVHDDSPLMSGVHMLPTVICMVLFTMLSGTMIEMLGYYLPWVIAGSSVSAIGYGLLSLLSPTTTTAKWIGYQIFYGAGSGSIVAGAYIAIQNLVPAPQIPTAMAIAIFCQNMGAAVSLIAANAIFSNSLRRQLQDHVADIGMAPEVILNAGVRSIRRLFERDSQPLAIVLQAYSDSVDKVMYLGIAVSVAAFAFGWGLGFRDIRVERKLIALRAESAKEEREDGKPTAAGQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C5P2</accession>
    <name>A0A0D2C5P2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239100.1">
        <property type="nucleotide sequence ID" value="XM_016377530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C5P2"/>
    <dbReference type="STRING" id="91928.A0A0D2C5P2"/>
    <dbReference type="GeneID" id="27330256"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03173"/>
    <dbReference type="HOGENOM" id="CLU_009555_1_0_1"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="456" mass="52200" checksum="F124778A0A5063F2" modified="2015-04-29" version="1">MSSTASARFWQTDLTRECFLSILPKDDLGSLRLVCKEYSKDIAPVLFKTLHVHFTANTFTRRARMSALERIGGYVRKLSFVMPHQPETFLPPLLVPDTLEEVTFIYEPHLFPSRPTSSGSSSTSGSNSKYGSWEMSDLLVKQYPPLFHAATNVESFSRAVCAMPNLRHLQVSCPGQPAGQRYRKDIVDYALISLRIAMEAANPTQLEMLTLAPVHPGTVLYLRPHLTFGSSPASSRVWRRIKRLDMEMDSFEYGRDQPADHLKILHSYLQALKSLEHFNFRWLGHKGPCPLALHIEPCTSRPTSLPCPNACPNSSSKSSFRPLKFRHLKTMHLSNASLDADQAAGFIMSHRKVLHEFRFDQCHLRSGTWDDALAPLTRIAGDDRWKEKQEEVMDVPLVLSPTDEKMEIECLREPLWDDVLSKNKRMEMLRKMSLRTRDLVPEQVKRLLRTTRLAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C7U5</accession>
    <name>A0A0D2C7U5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="305" mass="34301" checksum="F42BBF708CA6276A" modified="2015-04-29" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C924</accession>
    <name>A0A0D2C924_9EURO</name>
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        <recommendedName>
            <fullName evidence="9">C4-dicarboxylate transporter/malic acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016374969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C924"/>
    <dbReference type="STRING" id="91928.A0A0D2C924"/>
    <dbReference type="GeneID" id="27327687"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00604"/>
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    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF3">
        <property type="entry name" value="TRANSPORTER_MALIC ACID TRANSPORT PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="57312" checksum="BA71769242D90EE6" modified="2015-04-29" version="1">MPPGCRTTLPPGVHGYVMQRNRTGGLHHRPGDEDGCLDISARPSQGHEGWRTPTLEDTDLPPIPSESITDYSQYGAIAHRENMARPGVDDIDTDNDPDRKQGSHDHDDEAEKPKDLSWKQRMQHATWAWFTLTMATGGIANVLHDVPYRFKGLYTIGLIFFLLNIVFYLVIWAMIITRFVLYPWTFKASLTHPTESLFVPAFAVSFGTILINIVEYGAGEVGAWLHRTVVVLFWIDCGVAIGLSIAIYLILWSTLTFTIARMTPVWIFPAYPLLIMGPHAANLSDKLGGAMSQAIRIIIAGFTIQGIGFLVSLTIYSAFVYRLMTQKLPAEPLRPGMFVSVGPSAFTVSGTIGMAQNLQKVIASSPTYEFMDVPGLLAARILRLCANWMSLWLWGLAWWFFFISLLSNAQCIRTDHRMPFSMTWFSFIFPQTALTTATFAIAEAFNVNAIRVIGCVMTVILILAWAVVVACMIRAIVNKQILWPEKGEDKTEGGFKPIQRTKTNQSRQEAGSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C9J4</accession>
    <name>A0A0D2C9J4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450 oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00829</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240470.1">
        <property type="nucleotide sequence ID" value="XM_016375194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C9J4"/>
    <dbReference type="STRING" id="91928.A0A0D2C9J4"/>
    <dbReference type="GeneID" id="27327912"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00829"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="4117609at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57507" checksum="6945C02799D3B7DB" modified="2015-04-29" version="1">MNLLRDIQVLLADHWMMLLVFLLFRKLLFNKYGRGLHPIPGPFLAGFSDFWRFFCTTFSTVHQAHLNLHRKTNSHFVRIGPRTISISDTALIPTIYGTHSAFTKSEYYRLSMMPLDGAYTPSLFTALDERYHTSIKRPIATAYSMSTIIEYEPLVDSTTSLFTSRLDGFAASGVSFDFGVWLQMYAFDVIGEILFSQKLGFLESGTDVAGIMADIRGKISYAACVGQIPFLDRILTKNPLFLKIVPTHPIVTFTLDRMKERVASMAYGAGRKRDFLTRCMEAQARYPDIVTNRMIILYNGDNVAAGSDTTGIALRAIFYHLMKTPACLRRLVEEIDRAEEAGQLSNLVTWHESSRLPYLQACIKEAFRIHPVVGLIIERCVPKGGIVLRGHYLPEGTIVGMNPWVTTRDESVYGADADIFRPERWLEATPEQLTAMDRANLTFGYGKRACIGKNISMLEICKVVPQLLRHYELSFLQPDQEWTVRGGWFVWQDGFEVYIRRRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CA72</accession>
    <name>A0A0D2CA72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240670.1">
        <property type="nucleotide sequence ID" value="XM_016375394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CA72"/>
    <dbReference type="STRING" id="91928.A0A0D2CA72"/>
    <dbReference type="GeneID" id="27328112"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01029"/>
    <dbReference type="HOGENOM" id="CLU_003637_1_0_1"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000470">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="101"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="241"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="720"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1037" mass="114478" checksum="BE2F6CA1FFD40DAB" modified="2015-04-29" version="1">MGSSQPTQLTQPVEDPRRLGRNLSIVSEGDAVDVICILYPTSSAAIDAVKANLIHGRQHILQNEGLEEYSGDDIMFSSVYNATHDIALRISSQVKHPRDGFRFGRSSAASDILLTPNENDSLVSKIHFKIFVNSQGSLMLQDLSTNGTIVDDVHIKMKDRHGKIPARPATIALGNGSIISLFSGRDKEEIKFMVRIPSRGEKEDAYEENLRTYLSARGEVAQFASMRESSYGNHWNGGSLYNFTGLLGKGAFATVYRVQTKKEGDVYAAKELDKHRFIKNGVLDIKFDSELNIMKHLQHPNIVNYVDCHTYSHWIYILMEYVPFGELSQELRRTGRISERDGQQITRQIVHALDYLHRRNITHRDIKPDNILIASRSPLIVKLSDFGLSKCVTDQETFLKTFCGTLLYCAPEVYPDYASYKHGSAQKRRRLGEPVIRPPPSPYDQSVDMWSFGAVIFHMLCGKPPINGRGDDRGAQMLNNIMTKDVDFEPLKQAGVSDAAVDFIGKLLNRNPSLRPKEAECLRHLWLRNVPDLLEYSVLEPPDALDRKLHVVDEVDEDVLDDELIQDLHALTQPPSSAQSPDRAPKRAKTFADPVISPDNITYPSLPDVGDSFLPPTPMAHPAQRLFGEISQSVLRSSGLFGTELPPTTTADVHDIQNRVEQISVNDFGRLGSLGGADNAVIAGNTTEAAAATGKHHPRAGSAASLMGAEHQIGQLNMASPEADVSDAASPETNNPVTPRTRELSPSSSVSRHLDDGLGQTLTGTEEPIFTRRLDLGLVADPATFEAELEARNASRVGKLRAKADTFHGAITTTPGSPSVTATTIDAKTDYFGHPASAEDGVLRSFSNTAKMNNARAQKSGFIEPPKRFGKLTSIPGSFAKVNFNLEARFTSWGRGVDCTIKYPDSKDTRIPKYALKITFWAPGMEKHVEQGGDWTKMPAVRTVLATSASGCIYVNGVELRKESSDGDAALFGKIYTGDIITIYDGANGDFLKLRVEVTFGDSARNRPENEAGFMVQEERHHHQRMKERESMRMSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAM9</accession>
    <name>A0A0D2CAM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TRIP4/RQT4 C2HC5-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240855.1">
        <property type="nucleotide sequence ID" value="XM_016375579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CAM9"/>
    <dbReference type="STRING" id="91928.A0A0D2CAM9"/>
    <dbReference type="GeneID" id="27328298"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01215"/>
    <dbReference type="HOGENOM" id="CLU_027500_1_0_1"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="257"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="556" mass="60373" checksum="18C22CF97B44EA04" modified="2015-04-29" version="1">MSAELQAWALPRLQRLLPIDDESLREIITYTNSLTKEAGADHLKNLLGDSPQALEFISSFNARRPQVSSNRSPSQARPALTADESGVPSPKKRAARRTKPPLHATGPARTPEGYGNVSGGYTKHYDGDDHYSSPRESVSHNEDAPSRTGTADALQVPLRTTRVAPQSSAASRDASPALKSNKLPPSASGSLISDFGFANVRSKQSKKPAHPSHSQPQSGTATPQKGGPTTTTSSVADLTAAIAALELSTNPTLSKERRKCTCNASIHPLFETAPNCLNCGKIICALEGLQPCSFCDAPILSKEQVDSMIKALKEERGIEKMAAHNAGQTHSGRGTPLFGGSTPEALSGDESSSAAARARAHRDKLLAFQRENAQRTRVYDEASDYDMTLTPGATQWMSPVQRAAALKRQQQYIREMEEANRPEWEKKKTVMSMSIRNGKLVRTYERQNVPAAPEKVDNTEENAGVEEDPADQHLSVGGQGAFSNNPLLAGGKLIRPVWKAPEGEEKGKQREPERKSVWRRVQDDSEDNERWILDGGLHGYGAETRLMEDGSQQECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCE1</accession>
    <name>A0A0D2CCE1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_01744</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241380.1">
        <property type="nucleotide sequence ID" value="XM_016376104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCE1"/>
    <dbReference type="STRING" id="91928.A0A0D2CCE1"/>
    <dbReference type="GeneID" id="27328827"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01744"/>
    <dbReference type="HOGENOM" id="CLU_028723_4_2_1"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW21164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="165" mass="17675" checksum="1D6FFE74F9D90CFC" modified="2015-04-29" version="1">MFPTLPTDTSYTLYSRRHRHGRDIKAGDIVIFENPVFLRGLAIKRVIGMPGDYVVHDPSQSPTVGGAPVDDGTATRASEASASASASTAAGSTPPPAEPTMVQVPEGHVWVAGDNLAYSRDSRFYGPLPMALIQGKCLYNGDGWFSWRDIRDTGLQPVPGGEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y553</accession>
    <name>A0A0D1Y553_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MalT-like TPR region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230252.1">
        <property type="nucleotide sequence ID" value="XM_016386120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y553"/>
    <dbReference type="STRING" id="91928.A0A0D1Y553"/>
    <dbReference type="GeneID" id="27338895"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11812"/>
    <dbReference type="HOGENOM" id="CLU_553250_0_0_1"/>
    <dbReference type="OrthoDB" id="4159530at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="46090" checksum="D4C733E7D6027F92" modified="2015-04-29" version="1">MSRVQRPVQRDGKKMTVIAQRSPNAMQSNSLCHFQGPEISSTFHTQLLGQHYDSRQTITGRFIQGIGTLQKQILQESPESSTSELILRHIHFYYQWYPSKPQAIYHHTLSLSQVFDVIDEGLNLFVAGNPGAFSKFQEACNGAETLFRHQPFQIIVQFSACFSQLKWSNYPDFREALMRYLARMAIGVLGQNHYLPKILKLIPREHTSAGLSSRVIRITTDTTFSQFQGSSTDLLNCMPHLRLLVGRMHRDTGEESTLLRNLSQDVLITNLLGHDTPKDVSLLYKLGYLRLSQNRLDEAEELLTESLALAGQSPDASGARISKVYMLTLSCLGVLFGRRGDLITQTRYYRLALEWSTSVVPNEALNGEDKRRRMKWLDDIVRYHTLNGEELEVQSLREQYYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y6Q1</accession>
    <name>A0A0D1Y6Q1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230752.1">
        <property type="nucleotide sequence ID" value="XM_016385808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y6Q1"/>
    <dbReference type="GeneID" id="27338583"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11500"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF178">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="58"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="542" mass="60092" checksum="EB3D998B6F011E97" modified="2015-04-29" version="1">MAGDDYDLDVPGTEQLVDVNHEVHAVHAKGSSDIVLIPQPSNAGTDPLRWHRFKKYYQLFLLALYACAFSYGENTLGAAWTTVSEDTGVSLTNMNGGSALNYLLLGFVNIFWIPTAMKIGRRPVFLASTAICMCAGVWLGYFHGTASWMLAMVLNGVGTAAYQAVIQLSVFDMFYTHQRGRMLSFYLFGQQLGSILGLITGGSIADNLGWRWSQYIVAIIDGGVLVLLFLTFEETLFPRFLFSRFDGTVVRTGQPVSTVANTKDVENTLTSTETPSEPEVDNALASQFPKRTYLEKLKPWVYFPQDKTGYWQYFRRPFLLFTFPNIVIAGVIFAFGCTAGIVSFNTISEIMTEPPYNWSTTSTGLIFLAALVGNFVGWATGVLSDHIVIFLARRNNGIKEPEMRLWTLCFSFVYAAVGYQLYGWGANGGLHWMTVAFGVGSMIAHQVSACSIATAYAMECFPGIAGELVVVLAICSSCINFAISYSVQPFINATNYGYTFLFFGLCVLCSMLAAIPTYIYGKTWRRNAAPKWRTWLAERELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y730</accession>
    <name>A0A0D1Y730_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230922.1">
        <property type="nucleotide sequence ID" value="XM_016385978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y730"/>
    <dbReference type="STRING" id="91928.A0A0D1Y730"/>
    <dbReference type="GeneID" id="27338753"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11670"/>
    <dbReference type="HOGENOM" id="CLU_490041_0_0_1"/>
    <dbReference type="OrthoDB" id="4121170at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="501"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="501"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="580" mass="64266" checksum="4E7D8E21F9666BA2" modified="2015-04-29" version="1">MDSIIFEDPSKPRLRQKPQVSAAPVSSSTSLGRARTSEVEPRVVTPVPGIHQLREHSHTSNLGCSEPSTLRDQTSENPLEELCRSPLHNDSPGDGWTLEGTSFHDDFSLVQIDDDGLAERLDDDDDLDSLFSGVLPDLECFTTTESDQHSDAPAQTCASRVAGTSDIVNSSPSDDLVCFDTPGLRANSDAIDLAAESNCPEPKLTAAPSPQRCSPPSSRHKPGIEVVISTRRPSPITQRNLSSTQAADDLVEPNAARRRTASPHLGGHVKHISGHKRRYMSESDVDSLNSRRVRVEADPKNAPILVPHMLNDTANSRGIETHLHEPGRKVRAGIHNPVYGSDSEQTLIDHGASINCDDPTGRTLLLRELCPTPTSPPDTDEPFNEHGQEQHQDRLKGLSIQPVTLGDAGFVTAIIDSPADLQDIFHSPTDWALGRGVQSNNLANIVLKPLAERCWLLTATISRRVTKMDNQRRDRARRRRRDSPDLDTSSDFCPSESETISPPTKRGHWTLDEDNNLTEWRRRGKSWSWIFDQFPERSEAAVRSRWFVVLAPRAKPTYKSTSKLRRQRDGLPEEAVDYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7D1</accession>
    <name>A0A0D1Y7D1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231037.1">
        <property type="nucleotide sequence ID" value="XM_016384435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7D1"/>
    <dbReference type="GeneID" id="27337203"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10120"/>
    <dbReference type="HOGENOM" id="CLU_330370_0_0_1"/>
    <dbReference type="OrthoDB" id="4156398at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="854" mass="94028" checksum="016FDF2BAFEB1EAD" modified="2015-04-29" version="1">MSKEPWAITSTKRKAQSATPAPRKRPRCHDVESKDDKHTINQQTLTQVQWVTPVPTSFERSDSLEDIPQPRTARSRKLKKRNSTLTQMDFFSFPPPDHDDLDDDMMLPTQQQQSNLPQLDGSYESPRRPRKRKSIQHATARPAKRKSATTTLNSQEYLPRRKGGNKSGVETEQSVTPRRVSSRIASRQALSSDAAENLRYFQQALGIPEASRRDRGLPRSPAPLEIKDSVDEGEEIVFNDSRAHQSMPLRTPEKSRMVILSSQSPESLPPSTRRSKANTFKANIVSLRTPLAERSVNYSLSPSKGTTRKLRGAAKRSPGKGKVVVLKLPKRKPFQPRTRTDNHEAGLWSIPSSSPQLRQLQVDEPQSEQTILSHASGVDKPDIEPEIPGTSQGQALLSSPLAVLTQDSLPDLADIVGSRGGAVDEAKGNTSRELDLEDEESPVLVRDFAVAPMTTGLEVSRSHTAINKGFHDEVPLDGGADGLEGDLDVDEVDFGSPIANDTQFNFRLENRISSPSQPSPAPGGNVGTNAATPRVPSPTPHGHSRRPSTIGQSLDEEIPPQTPLPRPRLVESPCKWTPTVQGCEAEDPKEVALPTPALMHHSSTVVSITKVPLNDTLQQSSSSSPPLFRRATTQKSIHPASIPHPSQISTQEATQASPIMSSYPQRHDAEITQRPDQITIKDSSSIRVPLSQLPQYTGNSQSQYNARSGIDEVLDSEDEGDLDLDPSSLPSPPRKTPSNDRELIPPRGSIDTIKEEDDHYRDDSQNVSQLQTHGEADTTPIRSSQAISISSSPSPAPLQREYSPIPGFNNETQSNFTQNGHVTAAYIHRQREAGNIPKWYVPQPYQVPGYTRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7Y3</accession>
    <name>A0A0D1Y7Y3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED9</name>
        <name evidence="10" type="ORF">PV08_10310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231227.1">
        <property type="nucleotide sequence ID" value="XM_016384625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7Y3"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7Y3"/>
    <dbReference type="GeneID" id="27337393"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10310"/>
    <dbReference type="HOGENOM" id="CLU_097220_0_0_1"/>
    <dbReference type="OrthoDB" id="5414694at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="145" mass="15882" checksum="FF286A296711AEB7" modified="2015-04-29" version="1">MPSEPLPTAPSHPDVPPFPPPSTFSILPDIYLLIARLTILQQAAAGTNTLTHTTSGGSTTSTSTPLDLKDLPAQVYPIKQRIAKAKEAVQALPDVERSVEDQEREIRDLERTIALLKRRIAKLGRIAARTHGEEDRDVVMKGVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8J3</accession>
    <name>A0A0D1Y8J3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231532.1">
        <property type="nucleotide sequence ID" value="XM_016384930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y8J3"/>
    <dbReference type="STRING" id="91928.A0A0D1Y8J3"/>
    <dbReference type="GeneID" id="27337699"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10616"/>
    <dbReference type="HOGENOM" id="CLU_063252_1_0_1"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF2">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32741" checksum="B4094DE00B756B02" modified="2015-04-29" version="1">MSPPAVQLSFTLRTSPNVRTVHLLGSWDNYKSQLPLSLVKDPAAKPGSWKGTFRFQGSNALKLGSRYWYYYIVDGYHVSHDPAKEYVTEKTTGRKLNVIDVPSGDKDGSRVQRPSVTTTNLPSNRHSRDIPQGRALSPGKIQHPQPSKPYASRSLRQADYDASPIDDLEERFAGYRIADSSASPSELSDDGSSSGKAFSSSSPSSLSSVSDHSCRCERYGVTRSGQRVKLDCGGKRCGAWSSSSSECNSSTGSEDDSSEDEKYRRAHASAGRTTTAYASKGRSGGDDRRRTVVVEKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YA34</accession>
    <name>A0A0D1YA34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232027.1">
        <property type="nucleotide sequence ID" value="XM_016383404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YA34"/>
    <dbReference type="STRING" id="91928.A0A0D1YA34"/>
    <dbReference type="GeneID" id="27336166"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09083"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="355" mass="39109" checksum="677AC1C3091FC6B8" modified="2015-04-29" version="1">MSEKKELPTTLVTGGNGFVGASVISALLSTSHNHKVILAVRNTSSAEALVAAHPEWPNDHITIHAVPDFTVPGAFDSVFREHDDIEYVVHVAAPLLDDPRNTDFVEHFEKPSVLGNVGLLTSAKQYGKNVKAVSVTGSINAITLGDQDDVKKRVFGNDEWLSLDREDAIKAQHNYISYCVGKKLAEKALWQFVQDEHPSFTVTNFMPPLIFGPMEQNVTSVDKVNFSNSQILAIMNSATSSDDKKVPTTMFPAYIDVRDLAELQIQALTNPKAANRRFIVGFPMFFNDFADALRANIPELKGRVGENNDDSETLTPVRIDTHDADSVFDIKFRTLQETAVDTAARILKLEAAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCV9</accession>
    <name>A0A0D1YCV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233012.1">
        <property type="nucleotide sequence ID" value="XM_016382309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCV9"/>
    <dbReference type="STRING" id="91928.A0A0D1YCV9"/>
    <dbReference type="GeneID" id="27335066"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07983"/>
    <dbReference type="HOGENOM" id="CLU_107714_2_0_1"/>
    <dbReference type="OrthoDB" id="3468019at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16357" checksum="CBBBBE729C31F70B" modified="2015-04-29" version="1">MSPSTYTGATPADVQVDPRIVPFFETFYAVSDDPSAHEAYAQSFLPDADFTMGAKKTKGYDGILALRHGLWSGPIKTRKHTLTKIFPFGSGGGGGGELMLYGSVDYGLKNGKDVTCEWAARAVMAEYEGALRFKLYQVYVDSTPVANAIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDI4</accession>
    <name>A0A0D1YDI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233247.1">
        <property type="nucleotide sequence ID" value="XM_016382544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDI4"/>
    <dbReference type="STRING" id="91928.A0A0D1YDI4"/>
    <dbReference type="GeneID" id="27335301"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08218"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF424">
        <property type="entry name" value="ACETYL-COA SYNTHETASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="328" mass="35969" checksum="551926F22C93A66A" modified="2015-04-29" version="1">MYTFNEKVLSGESARQSPLQGCKDWSELMAPAEEAKNFQWGELPGDKCHKAIALNYSSGTTGVPQGVEVTHFNYIANTLYLVLLFATDHAMAQTIFIAGSLLREIPVNIMAKMMLKNIQRFKITELTLVPPIAVTLVKHPATKKFDLSSIESACAGAAPLNSETCRALEKICGKRFNMRQGWAMTEESASFGVGEPNANCEAMIMRIETDAQGNESFSEVTARGPEHTGELWVRGPNVMKGYWRNPEATAKTFSNDGKRWLRTGDVAYVDEGGCFYIVDRIKELIKVKGNQVAPAELEALLLEHPGIAAAAVIGIPTADGDEKPRGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDJ9</accession>
    <name>A0A0D1YDJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233277.1">
        <property type="nucleotide sequence ID" value="XM_016382574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDJ9"/>
    <dbReference type="STRING" id="91928.A0A0D1YDJ9"/>
    <dbReference type="GeneID" id="27335331"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08248"/>
    <dbReference type="HOGENOM" id="CLU_063954_1_0_1"/>
    <dbReference type="OrthoDB" id="5358398at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Luciferase" evidence="3">
        <location>
            <begin position="170"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="267" mass="29551" checksum="075C7BB7D2F37697" modified="2015-04-29" version="1">MASNHHYERLYAIGVILVGSGIITCLLNYINLETHPFLTSSKRGRALQNVCSRIFEHILKAISVSDPLSPPPSASTPASRGYLETLPRRSGPRPLITGIRRPHQVSQLSLPPEKQTHVSDRVRQVIADISARYPVATYLGRSSFEPGPSGSPTTTLYARHRMFDETRYYGEILRASGLDGSIHCTLHPHDVKTVIEKGWGERHPLSTRLAYWPTRVFCDIPAAPTADSRVVLYAPRNQSDLDAISQVVCAAVWWVGGIDTTIDDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDT2</accession>
    <name>A0A0D1YDT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233432.1">
        <property type="nucleotide sequence ID" value="XM_016382729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDT2"/>
    <dbReference type="STRING" id="91928.A0A0D1YDT2"/>
    <dbReference type="GeneID" id="27335486"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08403"/>
    <dbReference type="HOGENOM" id="CLU_040315_2_0_1"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="3">
        <location>
            <begin position="31"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="311" mass="33782" checksum="2752641B09DD1066" modified="2015-04-29" version="1">MSGPQKRPLSPADGTGDDGDIFSSSPILDRSSTFVAHFHPLTSSSTSSTPGQATKQASLTSTVKAFQSHADFASADHRMVAWRRPSAQRTLGLGPATSATKPIYTVGSDDDGEKYAGKRLERVLIDLDAEGVVVVARWYGGILLGPVRFTHIEMVAREAIGKWKSRQEGQAKRQKTIASSHQETPSVSGPSATDEAHQQAKLAKQLVERDSSIVVLRGLLAEKTAKLQEGGETSSQATSTPTTQPSMSPAKKIDYSEMPLQRLRQLDKARDATIAFILKQIDLAEEEEKNKNKKREGDTKEDTPEKAEVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDX1</accession>
    <name>A0A0D1YDX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08453</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233482.1">
        <property type="nucleotide sequence ID" value="XM_016382779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDX1"/>
    <dbReference type="STRING" id="91928.A0A0D1YDX1"/>
    <dbReference type="GeneID" id="27335536"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08453"/>
    <dbReference type="HOGENOM" id="CLU_007003_4_3_1"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="676" mass="75600" checksum="3E69F864879CBC27" modified="2015-04-29" version="1">MASSLPAPTPKNRVEKRGRQARTALTCANCRIRKTKCDGRQPSCKTCEVYHDTCRYEKIPPLSHILSMARKLQEYEQLIGELRQGSTPSDDPASRASFVEVARDSHVRGVTGEMSPTQVPAPTTPPVADPEPRAVAAGAVPGAQISDLSIDEHGRLCYHGPTSAVHDPSRVEEPSASVTLEDTPRSDADVRRFLRTRASELRSLEDFSVGNAALQIDIPKELVSKMLQLHWAWIAPMFLWVYRPAFMRDMASGGQYCSQLLVTVLCAHSSRFQGGELGKMLISRARLLLGGEIQKPSSIPTAQALLQLSARELAYGATSQAWLYSGMAFRMVSDLGLHHSNGRESNLSHLTVEDLEIRKRLFWSCYFWDKAISLYLGRMPTLTDLPSDHAPTLFDDHTEDEFWVPYYGDSGHFGSIPVHDYPRQKAHSISCFENSCKLAIIINDIMVQLYSHRPSSSTEQALSALQRRLDYWRAASPSHLKYDGDNAPLVCPPPHILAQNLLYYSTIILLHRPFNLNFAHHEACRKASNNIESLLLVLEKTFGFTRLTYLMAYCVYTGASAIIKDVRGGDVEASSRMGTFQRALQGALSTCPLVQRSLDIINNGLRSPERNQSRSLNSAVETEPQQYLPAFPNHDFLLDVDQWESRGSLDINSFPFLDCFPENHIDTEIGDWCLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YF96</accession>
    <name>A0A0D1YF96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233987.1">
        <property type="nucleotide sequence ID" value="XM_016383284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YF96"/>
    <dbReference type="STRING" id="91928.A0A0D1YF96"/>
    <dbReference type="GeneID" id="27336045"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08962"/>
    <dbReference type="HOGENOM" id="CLU_007426_5_0_1"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF74">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="677" mass="75590" checksum="94C50AB55645B9AC" modified="2015-04-29" version="1">MADHAQRTRPPPNRRRDKVQLSCGPCRHRKLRCDRQHPCGSCSRRGVTNSCSYAISSATPNAQRSPDTQASSNLHGRISELENLVLAFMNGQPLPPLPVPESPRARSLSSADGSPEIQKPNETSEETLSPADPGTLNLCESGSSYVQSGHWEAILTKIRGLKEDLVTDSMPPLGSHLFYGPNRHANRDEILAAVPPRPVVDRLMALHFDAYILNPYIIHRKKFLREYEAFWKDPSATSIAWIGLMFSMVYIAAQLQADAIDFAGGRVDSFKADPLTMKVAFREKAVQCLILARYTTGGPYILETLIMILAGECILVKESATDGWLLISMILHLAMRMGYHRDPDHFPGISPFEGEMRRRIWTTILSLDLGISLERGLPRSATDKHIDTKQPSNLRDCDFDEDTTEMPSPRPETEWTPVLPLIARGRLVRALGLVCDVIADINLPSYDEVVKIDTLLEDVHKRGIPPVLRWETMPHPITDSPNLVIQRVSVETTYYKSRILLHRMALTSCPVRQPPERDRESARICLDSALKILSFQAMLHEESQPLGRLCQLRWKVTHIFNQDVLLATSVLCLYLQEVDKFELSETAGQTTCLPRAEEVRQQLTISQQIWLQMSTSSAEAGKVAKALGIVLGNLEACAEDGSRPASDDLLTDFDTMPLNEFGATFNAQCEQSSLGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YI91</accession>
    <name>A0A0D1YI91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_07440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234872.1">
        <property type="nucleotide sequence ID" value="XM_016381770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YI91"/>
    <dbReference type="STRING" id="91928.A0A0D1YI91"/>
    <dbReference type="GeneID" id="27334523"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07440"/>
    <dbReference type="HOGENOM" id="CLU_000537_1_2_1"/>
    <dbReference type="OrthoDB" id="4119059at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="4">
        <location>
            <begin position="98"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="5">
        <location>
            <begin position="430"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW14656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="891" mass="96232" checksum="022519CB04D80B28" modified="2015-04-29" version="1">MGKLREVQAFEKSKASPSSHPSVDPAYDSDTSTQHLREVVMHKLSFSSDFTLNLDMIKGLDELSRGIEASSFTTASENTRTTTLPSYQSNQPVPPLNIVMQVVGSQGDIQPFVTLGLALQKEGHRVRIATHPDFQAYVQGCGLDYFNIGGNPAGMMAYMVKSPGLFPTLGSVLEGEVRRRRHEVRDMMTACWKSCFEPLEAGKSASTNTRARALSDALPFVADVIIANPPSFAHIHCAEKLGIPIHMVFTMPWSPTREYSHPLANLKSTKLDAKVVNLLSYFLVDAMIWQGLGDVINRFRCETLGLEAIHPSQAPGLIHRFGIPHTYCWSPSLIPKPMDWAQNVTVPGFLFSTQAKAYSPPQALLDFLDAKPAPVYIGFGSIVVDDPERLTALIFEAVRQAGVRAIVSGGWAGVGATGHSLQSHDDVRDVLLISSCPHDYLFPRVSAVVHHGGAGTTAAGLAAGRPTVIVPFFGDQPFWGKMVHDYGAGPPPIPFGELTAEKLAARIATAATSPVMARCADHLAERIRTEDGPQGAVANFHNNLPPSMYDGGNLYAGQVAVWRHGSLSRKLGVDVTLSALAATVLRKEKLLDWKDLQLNQTCEYNIGQLGPYEPVLGAVGAVRDLLYDALRGMGEILFDVVRVPYVGTQMIRQSRKNARMVEMESRLILQGGDHNAAERGNHGGPSKADEGAPLLRKATQDSWREGSTTKKTGFVGEGAVKGTLRIGKAAARAPGAFTLAMARGAHNVPRLWGDTTVRTQRQVTGISSGVKEGVKEFVFGVSDGITGLVMQPARGLMDDGLVGLAHGTAKGILGLPIKWYAAASGIVGYPLKGIDVEVTEALRGDRGMKAIRQSRVQQGELAWIQASDSTKDAVIETWKSLTLRAQSTKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJI9</accession>
    <name>A0A0D1YJI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016379530.1"/>
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    <dbReference type="GeneID" id="27332269"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05186"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="352" mass="38139" checksum="77068158C7987B36" modified="2015-04-29" version="1">MSLPTVTSRWVIRPTKDNGFDSLQYQDSVPIPPLGSHDCLVRFEAAALNYRDVAILQGNYPWAVREDVVPVSDGAGTVIATGQDVSEFQVGDKVCTLFHQGWQEGLLTPKKRVTTLGTYLDGVLRQYGIFPGKGLVPIPRHLTIFEAATLPCAAVTAWNALYGLPGRALQRGQAVLIQGTGGVSLFAMQFALGAGATVIATTSSSAKEEKLRAMGAHHVINYKDNPHWGEMAKRLSPGGEGMHHIIEVGGSASMAQSLKAIRIEGLISLIGFLGGKDAVSLCNFGDCLATLSIIRGVNVGSKEQFLAMNDFMTAHNIRPVIDDQVFSLEEAKSAYEFLWNQKQWGKVVVRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YK30</accession>
    <name>A0A0D1YK30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235557.1">
        <property type="nucleotide sequence ID" value="XM_016379730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YK30"/>
    <dbReference type="STRING" id="91928.A0A0D1YK30"/>
    <dbReference type="GeneID" id="27332470"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05387"/>
    <dbReference type="HOGENOM" id="CLU_1073761_0_0_1"/>
    <dbReference type="OrthoDB" id="4161306at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="259" mass="28092" checksum="5DA04020C6FA6337" modified="2015-04-29" version="1">MTVQSPPVCPRCSEQPESLDKLEQHVRASQSEPEVIKAPANVVNGQNALISLSQPLDSEANKAGEVLESPIYGEKDSLRRRRRSTLPAITKVPAPVSMSSRLPVNEVKSSHIKEEPFSILPKSDKRVTVDDTPPVSGHDAVLDSAEADAFTACNANTKTQIAIDRRSSDLMSTSTSRDTASTNSKEAKPTATELNSTVKRENSVIKRRRSPRKQSTVASTIATTKDKPPEPGSMQDTVPTRRSIVKELANFFSSGTSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMA1</accession>
    <name>A0A0D1YMA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236357.1">
        <property type="nucleotide sequence ID" value="XM_016380530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMA1"/>
    <dbReference type="STRING" id="91928.A0A0D1YMA1"/>
    <dbReference type="GeneID" id="27333275"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06192"/>
    <dbReference type="HOGENOM" id="CLU_038401_1_0_1"/>
    <dbReference type="OrthoDB" id="5393404at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="377" mass="41539" checksum="A9457CB5021FA937" modified="2015-04-29" version="1">MAPASSLSKYLDLDDLKFSSLELDARSAAELSTSAFRKRDASNILSPMDTFKVLTARDSKSTDHFNPGAGSVSPDDINMKGLQALFAIIGAAFVLGAIWFFFWAKNGGFKFRKGDWEEYKSTVLRRKGPNGTTLSNATKSTILGGGSVVGDGYSDKDAYTNADTDRMTETMTVTDMSSEAPIVKEKQSNKTKKETAKERKLREIKEATWEGGHDNDVRAYRHEKPARVGGLNKDSDAQFYGTDYTATERSTSDMHSNSEYSSNASAAHPPPPPAHRSRQSSPEKRQFRRDFSYGQEDGFSVGASDAQTGATRPTRYGSPNKNTESQRPIRTVPGSYTSPLDFDVQSQNTKTYHHPISGLQGGRTGGYRRDRRDSLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMB5</accession>
    <name>A0A0D1YMB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236377.1">
        <property type="nucleotide sequence ID" value="XM_016380550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMB5"/>
    <dbReference type="STRING" id="91928.A0A0D1YMB5"/>
    <dbReference type="GeneID" id="27333295"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06212"/>
    <dbReference type="HOGENOM" id="CLU_039639_4_1_1"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47578" checksum="4DBAF3B2EB634B3E" modified="2015-04-29" version="1">MSESKDIDTAVRATSLDFGRDGYGTTASASDSQSPMKHGEPHFVEPSPERPGDDEAAKKKTWRQKLAFFKTRDFWFILILGQILAICITGTNTLTTLLAMEGTSIPAFQTLFNYVLLNIIYTSYTLYKYGFRKWLNLVIHDGWKYIILSFFDVEGNYFTVLAYRYTTILSAQLINFWAIVVVVILSFVLLKVRYHWAQVLGIFVCIGGMGLLLASDHITGSNGGDVSSGNQLKGDLFALLGATFYGFSNVYEEWFVSGRPLYEVIGQLAFWGMIINGAQAGIFDRHAFRTATWNGDVAGYLVGYTLILTIFYSLVPVLYRFASAAFQNISLLTGNFWGVIIGLRVFHLHVHWMYPIAFTLIMAGHFVYYFGKGVMGEAQKAWLGENQERGIDGFGSAKRKIRKMQEEGTAGVRRGDEGTESMGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YME2</accession>
    <name>A0A0D1YME2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236412.1">
        <property type="nucleotide sequence ID" value="XM_016380585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YME2"/>
    <dbReference type="GeneID" id="27333330"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06247"/>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="68939" checksum="199257928DFA0358" modified="2015-04-29" version="1">MGSMGYKVTGNEYAHPLISERAIDEPRPLKVIYIGAGVSGICAAIQFPKAIPNLELAVYEKNADVGGTWYPGCACDIPAHSYQLSFESNLEWSKFYAGSPEILEYWRKVVDKYDIRKYMKFNHKCLEARWNEETSKWHVKFQKVGSDDIVEDIGDVFMTGTGVLNEWKWPDIKGLQDFKGRLMHSADWDPNYDATDKSIAVIGAGSSGIQIVPTLQPKVKSMDCYIRGRTWIAATFGNELVRERNNGQDGNFDYTQEEIDAWKKDPASYVKYRKALEIGMQGNFAMTHRGTKEHEGATAQFKEDMGKRLAKKQEIADHLIPDFPPLCKRLTPGPGYLEALTADNVNVVYDKISHVDETGITTSDGKHRPVDTIVCATGFDTSFQGRFPIYGRGGMNLQERYRVRPETYLTVSVDKFPNFFQSLGPNAGVGNGNLLIIAEAIALYVVQILKRLGQGNVKTIEPKREQVENFTNYCDAYFKRTVFSAECGSWYKSAPPNATHEERMKGRITALWPGSSIHAVRALEHVRFDDFEMTTVDGNEFGWFGDGWAIAERSGDVEGLSWYLNDTRFVHEPLQKGEKLVVNEDKVMKHTDDCLQNGEIAEGFRVPDGVAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YTQ7</accession>
    <name>A0A0D1YTQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_02920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238847.1">
        <property type="nucleotide sequence ID" value="XM_016377277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YTQ7"/>
    <dbReference type="GeneID" id="27330003"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02920"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_1_1"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="56"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="160"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="270"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW18631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="43411" checksum="B5CF1E9315CF2A1B" modified="2015-04-29" version="1">MSFERDPEQTPAILSPNQYAISTEETSTPRNHNTMPTSPPSNSLAPKLQIYSTSIPKAWISPICGAGAGFASGIVTCPLDVIKTKLQAQGGFQSRYQSKTQPHQLYRGIVGTARVIWREEGVRGMYRGLGPMLLGYLPTWAVYLTVYENTREFWYDQCGSWWVARCYSSLTAGACSTILTNPIWVIKTRFMTQSAKAASDGMRAPYYYTSTFDAARKMYRHEGMRSFYSGLTPALLGLTHVAVQFPLYEYFKMKFTGYGIGEHPPEDSSANWVGISAATFLSKICASTATYPHEVLRTRLQTQQRRHGFATSDGLAVKARYTGILHMCKVILKEEGWRAFYAGIGTNLIRAVPAAMTTMLTYEWLQSLIRRAQDKGEQLKKENGEQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUF8</accession>
    <name>A0A0D1YUF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_03180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239107.1">
        <property type="nucleotide sequence ID" value="XM_016377537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUF8"/>
    <dbReference type="STRING" id="91928.A0A0D1YUF8"/>
    <dbReference type="GeneID" id="27330263"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03180"/>
    <dbReference type="HOGENOM" id="CLU_047421_2_0_1"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="414" mass="46466" checksum="3E3D043AACC31105" modified="2015-04-29" version="1">MSDFTPNEESSIGSPAHKTSSPGSPPRRNLELLSTTPPGSPPSLALSLLSVDKHDTVQPAPNPSSKVEGGVFTMDKKLRQNKPRLLLMGQRRSGKSSITSVVFHKMPPQETLFLESTTRIQKDSVRSFMDFQVWDFPGQLDYFDPTFDTTEIFSEIGALVWVIDAQDDYSDSLNRLTTTILNLQNAFPHINVEVFVHKIDSLNEELRSDIYQDIVQRVNDDLSDAGYINPNITYHLTSIYDHSIFEAFSRVIQKLVPQLNTLENLLTILVNNCGMAKAYLFDILSKIYVASDSGPIDMEVYEMCSDYIDVIVDITDIYGYERSHNKVLGEQMQEAESSVTVHDGTMIYLKEMNRYLCLVAVIKNDGANDKKGLIDYNCHIFQDALNEVFARNWEKDKAAANGNGDQQAANAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVJ4</accession>
    <name>A0A0D1YVJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239532.1">
        <property type="nucleotide sequence ID" value="XM_016377962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVJ4"/>
    <dbReference type="GeneID" id="27330693"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03610"/>
    <dbReference type="HOGENOM" id="CLU_750131_0_0_1"/>
    <dbReference type="OrthoDB" id="4152170at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="143"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="369" mass="41851" checksum="627B0DC40E628817" modified="2015-04-29" version="1">MSIERRRINRFSGRAVRALPVAPVLTPDQQAEADMEKIIVGIRNMTIGLDSSRNPDLTIPPAVRTPAHAQVSITLNDQGGFHFGDAVTFSSASTTHPVRKAKGVNTNSSHNRGKAPTRSGRHAPSHVPPPLQDLSKIPARFNPPTLSSLPAELNSIIVSYLDAPSAVCLALTSRRHYDRVLATCRVDTLREVCPIDVRAMIPKMLQAYNLFYCRRVTTDAGEELVWELENKLEVYPIFGMFLFLALQRYESWYDYPNFSRDALDWRSVNRPAGRALDAWFSNHFSSQLYWTSTVMPLSVRHQLHRLALRPRTPSAEWELLRRRLSCSAILDKYQYCEIHCRWFTYGRPCTDYDIVLACLGIVRAEPEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0R5</accession>
    <name>A0A0D1Z0R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241432.1">
        <property type="nucleotide sequence ID" value="XM_016376156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0R5"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0R5"/>
    <dbReference type="GeneID" id="27328879"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01796"/>
    <dbReference type="HOGENOM" id="CLU_994103_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="280" mass="30115" checksum="2FB23A87C822C91C" modified="2015-04-29" version="1">MDANNSELSVVQGLVHNRVRELKGLGPIFESVCCPVSYGVVFAERYNALKHSRQGDVPEISALDGKKYIHGQIDWIIKKGVPIPSKGIKREYDIVLNDNASKMLPRSFQIVTTSHPRDRLPPNISHSAVKPVCDITIDLTKLKITTKQQHSTSGFGARALSNRLKRLRTNSNSAPPAAAAAGGGGAGAVPPPPSSPPPPPPPPAIASSSSSSSKETSFDLFLLIGASDLRFEIKPRGEPDILASSEHDQIDVVWAQDDNTITRTSTAASTRTDDMLLKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAE9</accession>
    <name>A0A0D1ZAE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230183.1">
        <property type="nucleotide sequence ID" value="XM_016386051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAE9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAE9"/>
    <dbReference type="GeneID" id="27338826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11743"/>
    <dbReference type="HOGENOM" id="CLU_008828_1_0_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF13">
        <property type="entry name" value="SPECIFIC TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW09967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="710" mass="78527" checksum="EF649DBFE8C3DCD5" modified="2015-04-29" version="1">MATGHSATRPQRRSRAKDPADRKRAVYVEEACIFCKGRKIRCDGKLPCGPCQRRSFDCRYTKPVHGDAPSASDAPASVSGSPSSRTSDSARLSDLTDIVARLQKKIALLEQGDSVSDHGIASTSPSRGQDVVDVEQPASAPGSSPVFAGPTSAEFSFGVANVILERESGQKSKLNPELAVAPSSRENEDSIPPAQAALPLHGLRLHDTLRLIQVYRETIGILYPIVEVDAMTRTATSVLSPEDPFGDRSTTLDVAQLKMILAIALLGEGGGSSPLAKSLHEDVKQVISDQTMALTFTLEGQALLLLTAFFHMNRDDSRLASRYVVIASRIMIESGLHLKQIRRRLFPHAAEHSRLLVVLTTCMYLDRQLNFNAGLPLTLKDTDVDIPEEETMPAYLMAMTSYMRMGPRAWASVTDDRGRLKYRINSEDFEFVEFQVRRWQANLPEDLRMDDGSELAFADALDNGTRSLRFILYLRANQFKIVIMRPILFSSQTFKANLEHVRQIIHLATDNIATILTMNERYGLYEKRQPLLNLFLSSSLSTLFLICVHLISDPRPELGRDVQGGIDRGLELLRLYSYCRSSQRLSDKFATLLQRLGFPEVARSRVANVPPPRHTDSSPDVAGDTVMVGADSSSTSASTSSFEFSSWNWSNFLPGGSPAEVSNDAFQFTASNNQGFPSFSYPELNPMPMIPYGTGQFNDDLLLNFITDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZBA9</accession>
    <name>A0A0D1ZBA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_11284</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230538.1">
        <property type="nucleotide sequence ID" value="XM_016385594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZBA9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZBA9"/>
    <dbReference type="GeneID" id="27338367"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11284"/>
    <dbReference type="HOGENOM" id="CLU_109098_0_1_1"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW10322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="149" mass="17050" checksum="1859A7EF3D097834" modified="2015-04-29" version="1">MPKNKGKGGKNRRRGKNENDNEKRELTFKEEGQEYAQVVKMLGNGRLEALCFDGEKRLAHIRGKLRKKVWINQGDIILLSLRDYQDEKGDVILKYSADEARSLKAYGELPETAKINETDTYGHEGVDDNVEFDEDRSSDSDKDVDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZBW7</accession>
    <name>A0A0D1ZBW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_11441</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230693.1">
        <property type="nucleotide sequence ID" value="XM_016385749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZBW7"/>
    <dbReference type="GeneID" id="27338524"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11441"/>
    <dbReference type="HOGENOM" id="CLU_002458_2_1_1"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="29"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="200"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="395"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="774"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="733"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW10477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="876" mass="98174" checksum="2C77AA3CA0B2A2BE" modified="2015-04-29" version="1">MDSTINHMLYARQSQGSNREGGSNSLSGILSTLIPTLIIAVVAFSAFLFVRSRYSRVYRPRSDERLFQEGWQTPKSDSSFFGLIKNHSTLPDSHVLRHNSLDGYLWLRFFKVLIAMCLVGCIITWPVLFPVNATGGGGQQQLDILSMSNVKHPNRYFAHAIVGCIYLGFVVLLLARERINFIGLRRAFFLSAAHAQRLSSRTLMVLGLPLEYQDEKALKEMFGPYVRKVWLVTDCKKLEDDVKERKKTGLKLEGAEMKMIKNANKLRNKTLKKQTSDTPTEQNALHWIDPKKRPQHRLKPQLWKKVDTINWSRGTLVELDRFVKEQQSEHLDLKHTKLPAAFIEFSNQSAAHHAYQSIGTGSLNKFNPRYIGVQPDEVVWKNLSVSNASRKAKLLVATAVISVMIIFWAIPVAFVGSLSNINYLTNKVHFLSFINDIPKVILGVVTGLLPVVLLAILMALVPIFCALLAKLAGESTLSAIELRTQSWYFAFQVVQVFLITTFTSAATSVTTQIIQDPGSAPTLLATNLPKASNFYISYFILFGLSNAALQLLNIVPLLMYTLVGRLLDSTPRKKYNRYISIPGLGWGSTYPKFTLLGVIAISYACIAPLILGFATIGFCLLYLMFRYNFLFVMGNKTDLKGEGYSKALKHLMTGVYLATICLIGLFAIGCSDDAISAGPLAIMVVFLVVVIIFQFLLDRALSPLEKTLPLELLQGNKFSTTVVEQIMDEHEMKQDQMEAGSASRGNSVPEFVKSEGEAPQPKTKPFNFLSRRLEPMLLKFYEANKSIVPAENDHNIPAYTSEEYEQAYLNPAITSPAPIVWLAKDPAGVSKILVQENREAGIDSTDSHAELDEKNKLVWNEDEVREAPLWQRPVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJP3</accession>
    <name>A0A0D1ZJP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233218.1">
        <property type="nucleotide sequence ID" value="XM_016382515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZJP3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZJP3"/>
    <dbReference type="GeneID" id="27335272"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08189"/>
    <dbReference type="HOGENOM" id="CLU_025093_0_0_1"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="396" mass="46350" checksum="5C3C2D77D4DDC994" modified="2015-04-29" version="1">MGGDLNLKKSWHPSLMTNQKKVWEEEKRALDERKKIDQIMKERAEEREIEELQALQEAAGGKKRQQRVEWMYSGPSSGQLGTTEEMEGYLLGKRRIDGLLKGTENEKLQKPTTTDSFMAVQNANNLRDTAAKIREDPMLAIKKQEQAAYEAMMNDPVKRRLLMKAAGGGDQDGEREHKRRKHRHHHRHREDRDRHEKSRSHRDDDDDDRHGRSRHRRRRSRTPSESRSRSPPRRVERPRSRSRSRSPYQKRHSYASGDRRPRSRSRPPSYSPPRRNGHGNGVRKMQSWHSSRSDRRRTPSPRRGRENDVDDQEDRAAKLAAMQQDANNLDEQREQRLADIAERERAQRERDDAARMRNAKYGGRADFVNSFHKKAGDLTLGQRMGRNGVSQRDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZMK3</accession>
    <name>A0A0D1ZMK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234223.1">
        <property type="nucleotide sequence ID" value="XM_016381121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZMK3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZMK3"/>
    <dbReference type="GeneID" id="27333871"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06788"/>
    <dbReference type="HOGENOM" id="CLU_078858_1_1_1"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000003">
        <property type="entry name" value="54S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW14007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="249" mass="27840" checksum="2D4BBB56B2580058" modified="2015-04-29" version="1">MASTSRILSSSRSQFSPPLSVAARTAQDLSRCSRTFSTIPARQDWLTPKRPEKRKSMVGRPRMPTGGSMRGTTVVWGDYGLRMRDHDRRVSAKQLRTGEQTIHQRLRGERYKLYKRVSANIGVYTKGNDVRMGKGKGKFDYWAARIPVSRIVFELKGNLHEQVVRDAFRLAGNKLPGLYEFVKKGDPPVVGITKLGKGVTLESLKEAKRPVEPKDKVPEQAITPPMSEGPPQSISTDFDKPPTTVHVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZMK5</accession>
    <name>A0A0D1ZMK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear condensin complex subunit 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_06793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234228.1">
        <property type="nucleotide sequence ID" value="XM_016381126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZMK5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZMK5"/>
    <dbReference type="GeneID" id="27333876"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06793"/>
    <dbReference type="HOGENOM" id="CLU_004446_0_1_1"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="552"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="508"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="650"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="796"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="830" mass="92674" checksum="A1C48909382CE490" modified="2015-04-29" version="1">MSVGEIFSDAQRSLVGHKTLAKRLRRLESTPNFEAHIKQCIFRLLDVSKSEVAGNRVIKFLTVYLEAAEGTNQSTSSILLALLPFLCAKDKTVRYRATQLVSQILGVLSTIDDDLYKVIRHELIKRLRDKVPAIRLEAVLALGRLVENEMDDEDEEGDSEEDVAPGLLEKLLDVLQNDTNADVRRALLLNLPVTPKTLPYLLERARDRDGPTRRALYSRLLPNLGDFRHLSLSMREKLLRWGLRDRDEKVRKAAAHLFRARWIEDCAASRSEQSDEEKKEQKGFYAPSIPALLELLERIDALNTGNETGVAREAMKEFWAGRPDYLDAVSFDDEFWDTLTPESAFMARTFNDFCQKSQDQKHQAMIEEKMPEVTRLGFHLQKHINELLIKVQNANETDSDEKLAEQAEQEFIVEQLLYIAQTLDYTDEVGRRKMFSLLRHALSMADLPEECTRLAVEALRLVCNPDAAGEREFTSVVLEAIAEVHDNIVSDEPEGVDADDDDASFVSARSEVSDHDPNSTPKNNSSSKNKKQNLSEEEQEAQAIKEIVINMKCLHIAQCMLQNVAGNLQSNIHLRTMFDNLVIPAVRSHEVLIRERGVQCLGLCCLLEPKLADENMRLFTHLLKKGHETLQVMALQILCDILMARGPPNASQPPNTLDGAASPNASSGDVDQPSSNPNNAAGGANGNSNTNTNMTSLLSPFIKALSQNFVEEVRATATSSLCKLMLCGFYKENEELFDQIVERAMQLGAKGWELLEKVKNAVVVDREKEKLLEKEREEQQQPAMANVTLFGARLSTEGGNGTGSARSSDGLVADDKMSGEGATNGVDVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTW4</accession>
    <name>A0A0D1ZTW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236458.1">
        <property type="nucleotide sequence ID" value="XM_016380631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZTW4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZTW4"/>
    <dbReference type="GeneID" id="27333376"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06293"/>
    <dbReference type="HOGENOM" id="CLU_2086516_0_0_1"/>
    <dbReference type="OrthoDB" id="4159019at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="113" mass="13123" checksum="91414AA65480E82A" modified="2015-04-29" version="1">MRADPGFIDGILEWTQQAYLLTHSAIRHWDFPGVKRFRVCDVAMHIRDAHRFRYDISGGGSGCRYWVRVIVSNMTKKGRIASTSANSLWPDLLYRYHTIQNRKPPSMVQGTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZUU9</accession>
    <name>A0A0D1ZUU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236713.1">
        <property type="nucleotide sequence ID" value="XM_016380886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZUU9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZUU9"/>
    <dbReference type="GeneID" id="27333635"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06552"/>
    <dbReference type="HOGENOM" id="CLU_025028_3_1_1"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238052" description="EamA domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48302" checksum="2F927280DE394731" modified="2015-04-29" version="1">MATKAVIPILVGMMLLTGCANTILTKYQDQQCVRDCDDNPKTFEQPVIQTVQMFIGEMGSWLVILGFYLYRFFILSTREAPLLYQPVNTDEPEEDDDVTVRPTSRNAPSPALKPLIPNADDRAPLEGWKLALLSLPSCCDIAGTTLMNVGLLFVAASIYQMTRGALVLFVGLFSVVFLKRRLYAYHWLSLVIVVAGVALVGLAGVISSGNRQPSPPQDPQETLLGVRLWVRSVVAEAASTEVLKTLVGILLIAFAQIFTATQFCLEEWILENYALEPLKVVAWEGLFGFVVTILVQVILHFSIGITKNGRYGYFDAEEGYRQVFTNRAIGISSLAIMVSIGGFNFFGLSVTRSISATSRSIIDTCRTLFIWLVSLGLGWESFKWLQVAGFALLVYGTFMFNDLVRPPIRALLPRRGEEEPSEHTHLLPEEPIEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZA1</accession>
    <name>A0A0D1ZZA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW17992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238208.1">
        <property type="nucleotide sequence ID" value="XM_016376638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZA1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZA1"/>
    <dbReference type="GeneID" id="27329361"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02278"/>
    <dbReference type="HOGENOM" id="CLU_005767_3_1_1"/>
    <dbReference type="OrthoDB" id="6486656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF17">
        <property type="entry name" value="SCFA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="186"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="677" mass="75739" checksum="A2C9B7A5CFFCC574" modified="2015-04-29" version="1">MPKLSQDRPSTSPIKLFRGLDTEGGILTDSDAIPDATPDQLSSTTIREKVIPVSELIECDLPAREATMMLFTTFIDSVHWFMMVFHEPTLRVELDNVLRTGSIGEHRLSTLILILVILLIATKYTREEEASLFLRAGVNLQLLQSRLLRIVEWKFLAVLDQDDIGALQVCVLLSSFYFYHGSPNRCLAMNSAAIRIAQKMKIHQESDWPSHIDKVEREVRRRVWWALYVVDGYGAMTYGTTNILQSTKCQVNLPENIDDTLDSCPGFNSCEQTADGSSCAVTTLSYQRFKFRLYRIAEPIMGEIYFHNGQPVHTLVKRVQQINQQLLEWEASVPPELRPKLLVSSGHQTDKRTNPVTKIFQLQALALQLSYDNIQLILHRPLLVYNGVLLLGPRPNTAQPLREAHLDQDANFWGVSKDLCWKSALRTACIDEYPSILKQVRNFHAASYAGIQTFTAGVMLGIFALSKPFSSQAQEAKRAIGRLIKTPKLLGYQTTISDQTGRILERLLRLVLGEELKLLTSDESTPSTGIAQPNSQALRHSGADTSRSNTQETFHHDGNTLGDSLDIFGTSTIMEDYCQSATSNSNSLPKSVCHPDYQPQAGQSNDGAIETQELNSRLDDSNDPANMDLCRIGENLEMPWSISDPAANGASFFDSSFLGDLGDLGQAWMWDESFQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZD5</accession>
    <name>A0A0D1ZZD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_02309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238238.1">
        <property type="nucleotide sequence ID" value="XM_016376668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZD5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZD5"/>
    <dbReference type="GeneID" id="27329392"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02309"/>
    <dbReference type="HOGENOM" id="CLU_097230_0_0_1"/>
    <dbReference type="OrthoDB" id="4120486at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="173" mass="19220" checksum="B5EF2B5A19E522C4" modified="2015-04-29" version="1">MADEVNLGPQPDFNIIATEILKIPNIPSLDGGQQLLAELRAIREQSTRDTMTIRQDMMTIRQDMMAIRQDIANVRQELVTVITASNHNNTARVQNTYLQSQNDNLVSFINATTGAAIPEFPQTSLELERMGRRRLDSVLQQLGIPTQGADLADKKRVLRAYIGLPEVTGSPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A527</accession>
    <name>A0A0D2A527_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_00482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240123.1">
        <property type="nucleotide sequence ID" value="XM_016374847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A527"/>
    <dbReference type="STRING" id="91928.A0A0D2A527"/>
    <dbReference type="GeneID" id="27327565"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00482"/>
    <dbReference type="HOGENOM" id="CLU_067676_8_1_1"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26545" checksum="26D402F572C3090A" modified="2015-04-29" version="1">MAPRSAIHETDPRWTAVEDYTSTHLFNPTRNKHHGVLEYAYRNSLEKGLPDIAVDPSQGKYLSLQVQLTGAKNILEVGTLGGYSTIWLAIGAGKNGKVTSVEVDPHHKNVAEENIAHAGFDDQVDVLLGKGTDILPQLVEDVKSGRREPFDFVFIDADKENNLAYYESALQMIRPKTCVYVDNVVRSGRIIDEQAIREDSRVIGARQLIEAVGKDDRVDAVVLQTVGSKNYDGFLLAVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A632</accession>
    <name>A0A0D2A632_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00822</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240463.1">
        <property type="nucleotide sequence ID" value="XM_016375187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A632"/>
    <dbReference type="STRING" id="91928.A0A0D2A632"/>
    <dbReference type="GeneID" id="27327905"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00822"/>
    <dbReference type="HOGENOM" id="CLU_007091_1_0_1"/>
    <dbReference type="OrthoDB" id="4236860at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF130">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTO (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="738" mass="83851" checksum="6F50BD3BDE77ACFF" modified="2015-04-29" version="1">MGQKRRRLALSCVACRRRKVKCDRTYPTCIRCQKGGVSCDYVSYTSKEGLPTPSDESPHQQREPSVASWNEEANVWYSRSKARASNVRPQDDAGNDPSSSTQRGPPPTKSLSELQDRIYDLELRLDSNRSRVTSEKFIGRPSLPGFSSDKNAFQDSERALLRGAGFKTQYMGPSHGASLLLQFEELSGFVKDILHRLPTLQKARSDWKQKRQAIRPSIVLPDHETLVSFIPDQATTDQLVQLYFEVFETTYRVLHAPTFFRSYKEFWIASHEPSTAFVVQLLLVCAAVNTVLPDRPNTFVGPSSVQRDLASKWIDVCETWLDLQSQKHMTLEVFQVQVLITLAKKMNCIKLKRSWTVAGHLLRLAMTIGLHREPTLLSKKISPFDQEMRRRLWFTILELEIQASLDRGMCASLGPLDWDCLAPLNIHDEDFDQTTEKMPRPRPMTEFTRTSFLCLAFRHLPLRLDVLSRINSVRNCIDSDHALDLDQKIRKHLDEIPKWTDHAAKIASLPLSELLLHEFLLQIHQPLVAQGETQSCHFFSRLARQDAALSTVRIYAELRSNTAVILTNMRDDVFPALLALCHVMIMSLESRDLMHDRNTTLKLIKQGVDTMEDRIRLVGQGFHSYWLSSSALGLLQSKLSPEKPPEVHAQETADRVAGLHRYMMDRQEDPADRMTVGVEDATMNTASALVGMSAQLPNPTMPDMDTFAPIGGQFNAFSDTLFDFDMADIWGAGNYQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A6V7</accession>
    <name>A0A0D2A6V7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240703.1">
        <property type="nucleotide sequence ID" value="XM_016375427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A6V7"/>
    <dbReference type="STRING" id="91928.A0A0D2A6V7"/>
    <dbReference type="GeneID" id="27328145"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01062"/>
    <dbReference type="HOGENOM" id="CLU_070025_3_2_1"/>
    <dbReference type="OrthoDB" id="104509at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052512">
        <property type="entry name" value="4CMD/NDH-1_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570:SF2">
        <property type="entry name" value="CARBOXYMUCONOLACTONE DECARBOXYLASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="46"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="139" mass="15327" checksum="8EB25B76697095FB" modified="2015-04-29" version="1">MASGDKVVEAHKTLYEQGIPVRTEVTGPQHVERSLQNNSSEFARPMQELATEWGWGSIWTRPGLERKTRSLLNIAMLCALNRMTELGVHVRGAVNNGATELEIRETLMQVAAYCGLPAGLEGVRVAEAILKGIREEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A715</accession>
    <name>A0A0D2A715_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240753.1">
        <property type="nucleotide sequence ID" value="XM_016375477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A715"/>
    <dbReference type="STRING" id="91928.A0A0D2A715"/>
    <dbReference type="GeneID" id="27328195"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01112"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_9_1"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="50548" checksum="9093C27BE111C39A" modified="2015-04-29" version="1">MSSADPHQNPHEEMEEDDLLAADDAAEEIPEDEDHPMDEDMDEEDLGEPQEEIQLQNDSAAHFDAHSDSIFCIAQHPSRPSIIVTGGGDDVAYIFDASTSSSPVVPTQEGQQQQPVERASLATLAKLDGHTDSVNAVTFTYPRGDYVVTAGLDGKLRAYASTDSSHKHWSFLSETSEVEEINWVSPSPNPQHENVVALGANDGSVWVYHINSADKASPLTIVQAFYLHTGSCTAGAWTPDGNLLATVSEDGSLYVWDVFGTGSAVVSLTAADQRFEVEGGLYSVACTASLCAVGGAGGNIKVVGLPQVADQAKKTAGKAKGGRATGAAASATAASAGQILASLQAQSDGVETLSFSSPPLNLLAAGSVDGSIALFDTVHRFAVRRHIKEAHEEYAVVKVDFVRNPTRGGWILTSCGMDGVVRRWDARGGTTAAGQGFIQEWRGHRGEGEGGGVLGFVQGGGGNRIVTAGDDGVALVFRADIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8W6</accession>
    <name>A0A0D2A8W6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA element modulatory factor 1 TATA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241443.1">
        <property type="nucleotide sequence ID" value="XM_016376167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8W6"/>
    <dbReference type="STRING" id="91928.A0A0D2A8W6"/>
    <dbReference type="GeneID" id="27328890"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01807"/>
    <dbReference type="HOGENOM" id="CLU_013114_0_0_1"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="702"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="470"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="715"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="819" mass="90597" checksum="00E2FD3DAA8336C4" modified="2015-04-29" version="1">MATKPTSTSRWNFLQQAVASVESRLDDILAEGGEPPKRSVSPAQPGRDLAPPNRISSELSRSNSNASTSNDRLQERLARAMAKKNTGRSESPVASATALAEQSPQESPNSAGNQTDQGLRADTSSAKTDLGSEKGDVVGLPAGNKVDAEVSHPPDESPYSQSQIPKIDISMQDEEGPTRASTEITSVNEVLPGRVTPESSRISEEDVPAVGTPGVQEDVSMYIEKIDALQAKLKYLSSEAAQSLKQAAASVQPGSLEKKLLEQEGKIALLIEEGNNLSKTEMKHVTTIKKMRAQLITTNREQEAAKLRADKAERSLKDMEDRARKAEAASRRAEQSLAVKASEAGELDAVRKERDALQSTLAEMKSQISKANARAEAAESQAKADQVAREQKRITELQDDLMSAKVEREISEEKLRREIKDLQATLSREREQTKALESEMLNEQAALESKLESFRVRAEEASSTDLGHVQAKLLRQIETLQSQYATASQNWQGIESTLLGRITNLEKERDEIAAREADLRKKLRETTLKAKSKESQLNEVQNMLAEKDKSLVDVEEESQRLSRRVAQLEADLADATREFEEYKVASEKELQRKLLEEKAKRTATLPLQRTDSPGTSIRKGAGLGLDINQFERPTSRKSFMMQSFEWSSPSRQNSASSFRNMTNGSIAETPSIVTSNDPDDFFANVPPTPLSTSHRGVNELISTSTVGAGPSVQLVERMSANVRRLESEKAATKDELARLTTQRDEARQEVVSLMREVEEKRTIENRIKTLEGEYESLSKRHQTTLELLGEKSEQVEELKADIVDVKQMYRQLADTMGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUP5</accession>
    <name>A0A0D2AUP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230664.1">
        <property type="nucleotide sequence ID" value="XM_016385720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUP5"/>
    <dbReference type="GeneID" id="27338495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11412"/>
    <dbReference type="HOGENOM" id="CLU_036220_0_0_1"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="457" mass="50031" checksum="10DE1466CC3367D3" modified="2015-04-29" version="1">MSGVEIGIAVIGAVAALVTAYKDAGGIVGNIKARRKTKGALPPSFALEESLKEGQEEIERITAKGIRRFGSDFEQGDDIAYRALQALIIEVQATFLHHLVTAGKDDEFVDFESCIDSAIEARLRAVTILNELYLRQQRRSSLVNEPVQQVLGQLRKEDNKTCGVEETNELKAPSNTVGPEVATAPRPPASRKSSWNVFKKHRRTSSTESRREDPSTVRGSRGSTATVTSPVLSASPGSFTLRTSRTSAILTPPISPASTWTPYDAITAAGFCEGAHYAQQGLYEKSVQVSMRNMEWSCHCRKCSFATPADKDERGRPRFDDNVYEASTLRFRPLLLFKSHLPSKEKKARSYKCLICILGGDSSSNFHGEVHLLEHLSHHQSALVGGVELVGPICLEAIGVREGSEKTFDICFPITSGFSLPAGAVELDDTAIVEADGNEYGEEEEVFKNQWVNEGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUR5</accession>
    <name>A0A0D2AUR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_11432</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230684.1">
        <property type="nucleotide sequence ID" value="XM_016385740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUR5"/>
    <dbReference type="STRING" id="91928.A0A0D2AUR5"/>
    <dbReference type="GeneID" id="27338515"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11432"/>
    <dbReference type="HOGENOM" id="CLU_074400_1_0_1"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="136"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW10468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="235" mass="25716" checksum="79627FC3A07DF101" modified="2015-04-29" version="1">MDTEDSLLRSDDVDPSLWDSPVKSSRDHQDPPKSSSKSAKSTRPTYQEQEERDAALRRELESVRQVNETIEGLIQSLQKAKDNMRTVNNTVGAASTLLNTWTRILSQTEHNQRLILDPSWHGASQDIADIEEEALEKQRAAERRDAEEQERKQAAARRAAEEEKRKADLAAKQARPTSSRGGRIGAGGRVPSASSTSYVQMGGSTSGVKRGTSSTRRTTSGIGRGTSGRGSRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWJ8</accession>
    <name>A0A0D2AWJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231076.1">
        <property type="nucleotide sequence ID" value="XM_016384474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AWJ8"/>
    <dbReference type="STRING" id="91928.A0A0D2AWJ8"/>
    <dbReference type="GeneID" id="27337242"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10159"/>
    <dbReference type="HOGENOM" id="CLU_874418_0_0_1"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF75">
        <property type="entry name" value="MYOSIN-16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="7">
        <location>
            <begin position="111"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW10860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="362" mass="40841" checksum="EA580D82FD7DAB3E" modified="2015-04-29" version="1">MYECLYGFTPFACDDRHQTKLKILQHKKNLTFPERPAAFAPSAEAVDLMMKILVEKERRLCTRQYQLNEYTRKIVGGKVVKFDADKTSSTYDGYFVYANDAAEIKCHPFFRNIDWAMVHLQRPPYIPHVDDWEDTKYFQEDEPVSDIESTSTFAVGNDKSTKAFNEHGELTLLPLAAHPSSNVSQHHHEGQNIVPSLAINIPHKDSAAPALGLARPDSLTDMKNPLLMPLGKPIASVEHNSWGREDTRQVDGANEGVFAGCRKPDAKQRDKRRARDIILRDKSTRREAMKIRKASAFLGYDYRQPAMVKDIVDQVLSEDVVMAQANAEYESSDVDDRDLAFEKRVFIGAGGHLSPSSEAVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXN6</accession>
    <name>A0A0D2AXN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231436.1">
        <property type="nucleotide sequence ID" value="XM_016384834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXN6"/>
    <dbReference type="GeneID" id="27337603"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10520"/>
    <dbReference type="HOGENOM" id="CLU_487475_0_0_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="236"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="559" mass="61378" checksum="317E4B6EA2C0DEE4" modified="2015-04-29" version="1">MQQADRQLENSPSSPVLEHNVFHARPRTGSYNSPLQVDRLDRSGSTNEADYLSVAAMGEPQKRDAFSHDPSFMTMVQEVTRLSTLSHLPSRSQQDQALPVELVISLDSIRDSLQQTCGQGLKQYAEIYGRYLGMLLPLIPADNWHSVLALASWIDRGAAHLPMDQPACEVMLCFSACLGLINSPEYDTARDTAQMMAAYCARQLPIALHRASDLAAVSSLSLASLLCLYLFDEASAWSYAGLALTKAISAGFHRANDQSEVADTTSTAFWSLYTLDRAFAVVLDRPLSVEDGDMTIQLPLAAPLTHSGQVGVDIRALSSWTVHYSHMFSSWKRNTAAGDDLVTRLATLTCWYDSCREIELVGGSISSEENASYILTQAIESQLTCRALVHLFYESVLGHAQSTSLLHCTEKLEAEVPQFFAAYKAALVAHVLAPTILDLWTIFSTTVTFVATRQPKLLGQLPDAARPAFAISVATMKVVLACEDLIRVISVRNRAVYGLQEVLWSFLDALEKSSQRPAGRAPSTDRPNHSESFNSAVSRCQLPIPRPLKHLMDLALTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYR3</accession>
    <name>A0A0D2AYR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231751.1">
        <property type="nucleotide sequence ID" value="XM_016385149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYR3"/>
    <dbReference type="STRING" id="91928.A0A0D2AYR3"/>
    <dbReference type="GeneID" id="27337919"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10836"/>
    <dbReference type="HOGENOM" id="CLU_048478_1_3_1"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="361" mass="39725" checksum="7108134442EB157B" modified="2015-04-29" version="1">MAQHLPHLPDWEQVSTNIIRILGGNPSKFTLQGTNTYLLGRGASRLLIDTGQGEKRWLDSLASVLRRENATVQTCLLTHWHHDHVGGVKDLKSLPSGSEAEIYKNTPTLNPDNLLDPSQVRDITDGQRFSTPSTPEEPATFEVEAVHTPGHAKDHMCFLVTSSPDPDEVGALFTADNVLGHGTAVFEDLGQYLDSLNLMKRRVVELSSSSSSSSKKPKKAYPGHGAVIDDATGKIDEYITHRRMREEEALNVLRYGTVKKPGSSEGVVHDSVTTVGESDSETEASSSTATTTTATTLGKEVAVGKEWESMEMVKVIYRHYPESLYQPAEYGLLMVLEKLRRDGKVVKTDDAKWRVSEKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZ93</accession>
    <name>A0A0D2AZ93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_09257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232199.1">
        <property type="nucleotide sequence ID" value="XM_016383576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZ93"/>
    <dbReference type="STRING" id="91928.A0A0D2AZ93"/>
    <dbReference type="GeneID" id="27336340"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09257"/>
    <dbReference type="HOGENOM" id="CLU_044117_2_0_1"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="354" mass="39002" checksum="14FE36274314AE67" modified="2015-04-29" version="1">MTAVQQKVQDVVKHYRPARQFPGSTRSDGIDSRVTSLDFDDMGEFLVAASDDETMQVYDIKEGKRTKVIPSKKYGIHLARFTHHPRNVLFASTKQEDSLRLLELHNESFVRYFTAHTAQVTCIALSPGGDQFLSCGNDDMVCLWDLNSRSPQGKLKLVTPYLAAYDPSANVMAIASQSTSSILMYDVRNFDKAPFETFDMSQAEDRYTPTTKGRAWTRLEFSNDGKSMLLGTDYHGHFLLDAYDGAIKSFLVGKTTGTGRAAPVSTSGKPLGQGDACFTQDGRYVIGGSGDQSDLMVWDTQAATGGRQDPTARLASRGIKSAVVQCNPRYNMLATADTKVCMWLPGDQIKTPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZA8</accession>
    <name>A0A0D2AZA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="3 15">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PV08_09267</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 21">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="3 15"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232209.1">
        <property type="nucleotide sequence ID" value="XM_016383586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZA8"/>
    <dbReference type="STRING" id="91928.A0A0D2AZA8"/>
    <dbReference type="GeneID" id="27336350"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09267"/>
    <dbReference type="HOGENOM" id="CLU_027287_2_0_1"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021162">
        <property type="entry name" value="Dot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017570">
        <property type="entry name" value="Histone_H3-K79_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="18">
        <location>
            <begin position="192"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="341"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="426"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017570-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KIW11993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="538" mass="60817" checksum="ED82785FA1A974F5" modified="2015-04-29" version="1">MSSLPSQGRPLSGLAALKAKKQPPKMLTKMVTVASTTKPASRLSASAPAPSHNVRSANSHSISRKTSVPRKSLTPASTHSRQGSREPIERIKHEKHSRVKRASPAVSTPQFTSSDEESEEEDKPRKRMRTDGQDAVDEKRKVRDLQAFSEDGSNRLSMIHAIQVANPQPDQHGKVKYEEFFKTLKVDEDEYPVIELQYPTSLQGEKYQLLRPIDSSDFKPLDEIEANMKMVAEYYLDIASARKVDNEEEGSGFVQMLHRHATHGLKGRVGAQTEYIKTIEKYNSLMKEKRDDGTIAKKLDQMKQVELKLAEHIIRGQVYARTVSPKVESVRQYEAFSNSVYGELLPKFLSRIFRETGLKSEHVFVDLGSGVGNCVVQAALETGCEAWGCEYMDNPNELAQLQATEFRARCQLWGIKPGDVQLIHGDFLKNDTIRQVLKRADVVLVNNQAFSAQLNDNLKYMFLDLKEGCHIVSLKPFRSPAHKIKESNHNDPINVLSVVEKERWSGMVSWTDDPGKWYHQRKDRRELDAFLKTMGGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZT3</accession>
    <name>A0A0D2AZT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
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            <taxon>Chaetothyriomycetidae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="4120129at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="135"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="340"/>
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            <begin position="94"/>
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        <location>
            <begin position="303"/>
            <end position="316"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="418" mass="45044" checksum="23B29DF2B092C211" modified="2015-04-29" version="1">MPVFEISADSPVRGAPEGSDSGDLVDKLQDVPRAMAYYDAPRFSLPSSQLRLRLARRLQAKRPRRNNTAAAHHHASDDPADQSTVDRATPAVAPLDSSSPLPSSIHSKVRRQRLVKRSHSLYSRPGESQRSEAEIETETDLVDAAAAHSISDKRIFVRTEITISESLELDLAPDRSHIPRLVTRISGPEVGNAVSGSRLSSGEPISEPHPSPTAFVESISRQFNDGGPSRPSSSPSSSSQTPSADDETGGSGRGAAVLGVRTPTTTSTRRWTKRRWSIASQPTLSSSTATTRCSSRHRENEGSSSSLSPTPAPSASRLGSEVAGTTDEEHATQSKPGTRTRFRFRIPDFLRPLDEPLPPTRTYDLVLRRDLFSRAQPGNEVPLTTVQNGSRKAQAKAVRASEAGLARSGSCPVLPPFT</sequence>
</entry>
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                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF10311">
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
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        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="27336539"/>
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    <dbReference type="HOGENOM" id="CLU_1414987_0_0_1"/>
    <dbReference type="OrthoDB" id="2117996at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
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    </dbReference>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238743" evidence="1">
        <location>
            <begin position="19"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="191" mass="19730" checksum="13015AA4C1A6E463" modified="2015-04-29" version="1">MKSIIAASLLALIGTSAAAPSTLRFAKRDSPNGCPAGDPGQVGVINAIIAWNSDVVTVNGFLDSSVTVLSDPNQILSALQTVLPAAQNEPTQLQVLACESDVLPGTAAQAAVDDLFGGFESNVLVPLMNIMNGADDADTVNSNLHTINQFRCCNVLPDLDTLWTATAVDEGVADQVPLSAPRPNACSIITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0U6</accession>
    <name>A0A0D2B0U6_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="2 3" key="1">
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                <person name="de Hoog S."/>
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                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
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        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="114" mass="11833" checksum="B3D8AAC5A9476B7D" modified="2015-04-29" version="1">MFLKQTAYKPRTLSGSSGTSGKQSLKDENGSGTTTTTTTTTTTDKVSTETTGPAASAGAAGRRRSSASSETKFAGLHAYKRNGGADERKSSWAEQTPGSPGMLQGMWNSFTKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B368</accession>
    <name>A0A0D2B368_9EURO</name>
    <protein>
        <recommendedName>
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    </protein>
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                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
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                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="91928.A0A0D2B368"/>
    <dbReference type="GeneID" id="27335300"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08217"/>
    <dbReference type="HOGENOM" id="CLU_006329_9_2_1"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="205"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="698" mass="78241" checksum="8AC0AA8AB07ED260" modified="2015-04-29" version="1">MASSHVENSLPASSVTQIPRSAAAGDKRHLPQITSSGESVPEDLGRPNLGGYVEATFYPFLETLFIRNTLVEDFDYLSHIGSLQVPQRRYLDELLKAYFLYIHPHLPLINEGDFWDTYLDNQSSRSNSSCMSLFVFQAMLLAACSFVPTTVLQFLGFCNTRLARATYYRRAKALYDFGTQRSNLIKAQGALLMTFHVPLNEPHINSHWLGIAINHAKAESADQFYRYAVHDAVRYNQMKRLWWCCIIRDRTLSLALRRPIFISSKAFYDVWPPLTEDDLRSEIERSHVCTASTKMSILKSLIALCELCAIVTDILSLLYPLDSTTANDDHLELMTRIYSFTDNLNEWHEQVVSIIEPRHHNGNEVGIVVLFSNMLNILFQSAKAALCNHRIMLTVSETLQHSFERLHAKNELQAALRSTAQSLRAIIEAGMITYSPISMVAFLALPSICYNLNLTNRAQPQRPSQTYGTNIYQDFLRVLQLRYEGTDRALSNMAKLMSDMNMEDATSPSTARSDSTSNISSNQRQGRTSSATLATTKSVSGIDIVVSDPQKYVQICQTLDFFLSRGRFPTRYDTSSSIPSPPTAPERLPSAGMPVWATAEGSGATGRGQFEQSMGRNLFSRDMALDSANVDTSAESSELLPTSETSTAAVELSVALLDNPFQEAIANPEYFLFEDFETFMTDGPYRGADRSQPNTLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B472</accession>
    <name>A0A0D2B472_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_08959</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233984.1">
        <property type="nucleotide sequence ID" value="XM_016383281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B472"/>
    <dbReference type="STRING" id="91928.A0A0D2B472"/>
    <dbReference type="GeneID" id="27336042"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08959"/>
    <dbReference type="HOGENOM" id="CLU_070101_1_0_1"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW13768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="208" mass="23241" checksum="9EAE6E16D060CF21" modified="2015-04-29" version="1">MYLHSLPRAARTSTSSLKTYTRMTSSQIRSFQSSTRSLAPTFSATQQPPMTSQSHVRSAHAISNPTLAGIEKRWEAMPPQEQAELWMQLRDRMKVDWHEMTLQEKKAAWWIAFGPHGPRAETPPGEWTKVWLYTAAGVGLSAVLFLGIHSLARPPPRTMTKEWQEATNEYLKAEKSNPIYGISSEGYSGKGHVQSKSAKAQGISLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5X7</accession>
    <name>A0A0D2B5X7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234281.1">
        <property type="nucleotide sequence ID" value="XM_016381179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5X7"/>
    <dbReference type="GeneID" id="27333929"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06846"/>
    <dbReference type="HOGENOM" id="CLU_983523_0_0_1"/>
    <dbReference type="OrthoDB" id="5383057at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="296" mass="28962" checksum="8D76252C5406C271" modified="2015-04-29" version="1">MSFTANSKAPQPHPSQAPQEPIGPVAADSLAAESLDNYGKFSENERAAASSVTGSSSTLNTTDTSGARVLQPAPDNTTREKQNMSSLGADERGPAGVKLDALGKPQFPGGHDESGYFGGPGGGGGGASRAAEGGGGVPAGASDFGASTYASGSRTGPDPNIKSSTGAGAGGGGGNSGNSDNSGTSAGVRPHVDPAPTYTATVTGAAVPPGTYKPKGTNIEDADKTDGMPKTKTFVGDVGGQHDPGRLAERDFEARNTGPVERNTSAGTAGGAQRQAGSGAVGEEGGSFGVLNGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B742</accession>
    <name>A0A0D2B742_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_07274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234706.1">
        <property type="nucleotide sequence ID" value="XM_016381604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B742"/>
    <dbReference type="STRING" id="91928.A0A0D2B742"/>
    <dbReference type="GeneID" id="27334357"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07274"/>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="OrthoDB" id="4105682at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF20">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="43"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="440" mass="48899" checksum="DFD70656F4DC5B04" modified="2015-04-29" version="1">MGILQDPQPLSGSSHFSSLSPVETDEVFNLLGAYRQDTHPSRVNLGAGVYCTDEGESWPLRVVERVEKSLYEDRDPRRHDYIPIEGDRRFLDVARDLVFSSSSPTQPPSHAGKRLSQQSSVSPDRVVSVQTISGTGANHTGARFLAETLRPGCVWLSDPTWANHHVIWSSVGVAQRLYPYYDARNCTVDFSAMMATLEREAQPRDVVVLHACAHNPTGLDPSRDQWAAIAELCRRKQLFPFFDSAYQGFASGDPARDAWAIRHFCELQPPQELCVAQSFSKNFGLYGQRAGAFHLVVNDASMVTRASVLGRLAGILRSEISVSPRYGSTIVRTVLESEDLTHAWLADLQVMSGRIKAMRLALYSELCRLQTPGSWKHIVDQVGMFSYTGLTPAEVAILRERYHIYMLSSGRISVAGLNTKNVQYVAAAIHAVRTQQAYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7D0</accession>
    <name>A0A0D2B7D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein NO VEIN C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234776.1">
        <property type="nucleotide sequence ID" value="XM_016381674.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2B7D0"/>
    <dbReference type="GeneID" id="27334427"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07344"/>
    <dbReference type="HOGENOM" id="CLU_000570_3_0_1"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052957">
        <property type="entry name" value="Auxin_embryo_med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387:SF0">
        <property type="entry name" value="PROTEIN NO VEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387">
        <property type="entry name" value="WU:FJ29H11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1666" mass="191043" checksum="833E993F215D0958" modified="2015-04-29" version="1">MSKPGFDGNGRPLNVAAARAEINRICRDRGIIDDYDESQIRKTDPSFQEDYRRRAAEHRALYARYTKSFTQQLYSSRFRFIYELLQNGDDSCYANDVEPCITFRIKSCELIIESNELGFTLENVESICDIGKSSKASDTDTTGEKGMGFKSVFGIANYVHIQSGVWSFRFEHRQGEEGVGMITPKWTDVTSRLPSNIGTRLTLRYYDQRDIFTTRLVSEFEKLPRTVMFALRKLKKLVIVVDGVAGRSDCITFEKDGDLRSHQMCIKTTVTGTFGAHKSATTFLRLFQNTVRHLPSDTHRASSESDVTVAFEVDSDGQPVIPANGQHVFAYLPVQRIVQLPFLINANFVLTANRESVSDTDWNIALRKGVAVAFVGFVNKVVISGDPLEFKWMHYLPKRFVKGFWEHLWRDIMELILHSDLLILRSRRNELHSIKHMVSLPDWFIHDNEPIVADTDEDIYLSDNYKPCDLRILRELGVWEISPTLILERIEFGLSEGAKTPIHHIPLNDSWHTAFAALIRLVLERSIKYSVEQLKLSVEQLRVIPLDDNRWVSISSLDADPVYLPYLVDEVSVFVRIPDYLGFKKLHEIAAADRERVSFYTSVGITSCHPDAVTAKIFEMHESAQRIGTLFMFKMDLEVLFWFGKQPSLSMRGQMSMLLVSNENQKCRGPFLFFPSEDNYHAEKLLAATPEKDKSPFGILHQQYLQSPASNYIRHGLDWKSYLQQWGVKYFPDLVQKVPARWKLHPLMKLIARDNPDRFVANLKAHWSDYSVDVSMIKTELMNVRVPCLNGSTQRLCDTILPTHELIDKSRDPNLTNLLPILKLSRDCDVQQPETWFFLKEFGVICEVNTDFYLRAISLLVSLKDRPLLSTCETIYSGIAQTTAVKDANTIQQQDFATRPLIRSNRIEEAWHKSTDCIWEGPSFLRVKQVLKPLYGANPSASSFFKSILNLRDVSYDDLIDELKIPSTKATERSPPIESKASEVYSALNAMASSESVIQTIRYQLHDNNLIYVDQQWLKPSECLWNCTIAISGRQPLDHLYPRLKNFFVDKMKVRTVNINVLLQELGRTAQKTSPDFDEIKRIILTIGEVLASDPEVEVNEEHLRSLTKTAFLPIRGPSGLKLFSVDQAFAINDHQRYGQLFENKAKILDFGHEEMTSLYPLFRLLHLEDHFLSRLVEPKTTVHMPTAHPALEHYIRDRAYALSCCANYYNSPKYYNRNTTVHKLLLTAEVFVCEDMWTELALPEKHDSITVQSDRAVVKICYSHVKLAIYVPGDYDGLYSCFHTALPRELANALSIDNERAVKVVYRILNDDKKDMEVIMKDEDLPGYPWFEKPATPLQTVSFPALNDTEPHRSSLVLLVSPDNTSSGHDTDDDDVVTRVDQRDAVPHSRVESSMLSPVHIHSTGSHYTIWEEVARDQQYQRLLREVIRQARRDGRSPQKKGGSLSLDKIDEALDELAHPQADYATFARMFGRHRERQIEENDRVDAAGELYVFELLKACGVTNFSIENWQSSIRRYVNILPEYASEPSWHGREISDIMYEGNCPQLMKLLRENTTLPYPAWLGLGSSGTSTSRPAVNYHIQVKTTPWSCDTPFFMSSNQYRLMRDKACLNDSMTAPRDVYLIMRVWNLFSSSIGLQVYVNPWHLRDAGIKFVADPWKVVPMSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7G6</accession>
    <name>A0A0D2B7G6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234831.1">
        <property type="nucleotide sequence ID" value="XM_016381729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7G6"/>
    <dbReference type="STRING" id="91928.A0A0D2B7G6"/>
    <dbReference type="GeneID" id="27334482"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07399"/>
    <dbReference type="HOGENOM" id="CLU_032923_1_0_1"/>
    <dbReference type="OrthoDB" id="5068804at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238888" description="Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="2">
        <location>
            <begin position="239"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="428" mass="47230" checksum="3A61243E6923F7E9" modified="2015-04-29" version="1">MAEPIGLASGLLALASFAFQSSIALYQTLHSFQSHPKRVRDLLEELETLSEVLSPLNETIRATADESFSALDLPLLRCGNSCKEFEQEIIKCTSRSAGGRTSFRDWAKLKYMGEDIDGFRRLLAGYKLTITIALTDANLRKTAVTAEALEGYQDLIKTTTADLEAHLASIDEKLEAAFEHAVPESDADAAEKQLIKEEQLSTRRCLQICARLSEHIGQIQLTPRDNASGVADPDTFPEHITSQGLQECKNSLQSTAAKLETYLHDLMDRMISKSRTAGTSTEDFADLTRLREEWKTTRQCMEICSQADHRLKENITTIDNYATGDAIQFMVSTDGNIVHGKNRGLGWRTRQVGGHLNDASLQQLSRDMVSIHKLHIHNSVSTSQSDMLSASDDAVENAGVSDFRERYGQGFKLTSKSTPTVPGTGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7L0</accession>
    <name>A0A0D2B7L0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_07454</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234886.1">
        <property type="nucleotide sequence ID" value="XM_016381784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7L0"/>
    <dbReference type="STRING" id="91928.A0A0D2B7L0"/>
    <dbReference type="GeneID" id="27334537"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07454"/>
    <dbReference type="HOGENOM" id="CLU_018787_1_2_1"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="302"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="442"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="478"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW14670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="520" mass="58748" checksum="28A1ADB68985096F" modified="2015-04-29" version="1">MASVAPAFGDVSQTHPYTCNSCAVAFRNSDAQRTHMRSDWHRYNLKRRLAELPAVSSEDYNEKVLAAQASNNAAAAQAAFAKVCTQCQKTYYSENAFQNHLASKAHRMKGSIASGKISRERTNASDSAVSKVVSSEDSEIRDPEAEAEFEQVVAGMKDTSIQDLPAIARRPSAPGPDADPREDHPMSPEKPEVSSIPLSRCLFCNYDSPNLKLSVLHMTKIHSLFIPEQHYLVDPEGLVRYMQAKVYQNYECLYCHRLRGNADGAQTHMRDKGHCKIAFETEEEMIEVGQFYDFSSTYSDDGVDDSDTEMDASKPTQNGGVKLANGENHEEDGWETDSSFSSLDTDELVSVPNDDRTSSYQRLPLHRHHSNADPRPHRNVDGFHSHAHHHNNAVFYDEYEMHLPSGRVAGHRNLRKYYKQNLHSYPTAAERMERAQRLIEEGSSDADMEDIGDLPATPPRNSLIRRGEAGMLGATSQQRRDVRSQEIRSRQKEQRSQNRYQAKLEKANNHQKHFRDPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8R5</accession>
    <name>A0A0D2B8R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_07822</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235251.1">
        <property type="nucleotide sequence ID" value="XM_016382149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8R5"/>
    <dbReference type="STRING" id="91928.A0A0D2B8R5"/>
    <dbReference type="GeneID" id="27334905"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07822"/>
    <dbReference type="HOGENOM" id="CLU_015741_1_1_1"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="70"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="312"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW15035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="428" mass="49149" checksum="3CF4064973E23C55" modified="2015-04-29" version="1">MAHMNGENVKRKASEDASSSRSKKARTESPILDEGDVTKQEESDSEPLITPTPVDFPEKSAVLEEKQGLIEFRVVNNDNSREHNIILTGLKCIFQKQLPKMPKDYIARLVYDKTHLSIAIIKQPLEVVGGITYRPFNSRKFAEIVFCAISSDQQVKGYGAHLMAHLKDYVKATSPIMYFLTYADNYAIGYFKKQGFTKEITLDKSIWMGYIKDYEGGTIMQCSMLPKIRYLQVPRMLQKQKEAVMAKIRAVSKSHIVHPPPAAWKNGVCEIDPMSITAIKESGWSPSMDELSRQPRHGPNYNQLLHLLNDMQNHTAAWPFAQPVNKDEVPDYYEVIKEPMDLSTMEERLQNDLYPRPEDFIKDAKLIFDNCRRYNNETTPYAKSANKLEKFMWQQIKNIPEWSVSNAVIFGIFDRFADFSLAPCRLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B984</accession>
    <name>A0A0D2B984_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235436.1">
        <property type="nucleotide sequence ID" value="XM_016379609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B984"/>
    <dbReference type="STRING" id="91928.A0A0D2B984"/>
    <dbReference type="GeneID" id="27332348"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05265"/>
    <dbReference type="HOGENOM" id="CLU_097653_0_1_1"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="86"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="177" mass="19799" checksum="C65978FC824379E1" modified="2015-04-29" version="1">MTDVEGASHKEQILEACRRDNVELFNEVLADMKEKSKEQIAEFFNTVTDTMGNHLLHVCANYGAYDVMDELLNVEFLECDPITRRDKETPIHSAVKYANEREVELGEAMAKMLIEAGGDPRVKDGHGRKPAEICTPRTEELRGILIKEEYVLNEGLKNADSHQDDDDDGAGSASDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9S3</accession>
    <name>A0A0D2B9S3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235954.1">
        <property type="nucleotide sequence ID" value="XM_016380127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9S3"/>
    <dbReference type="STRING" id="91928.A0A0D2B9S3"/>
    <dbReference type="GeneID" id="27332871"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05788"/>
    <dbReference type="HOGENOM" id="CLU_630102_0_0_1"/>
    <dbReference type="OrthoDB" id="4757558at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="435" mass="49606" checksum="E3337B45C5780EE7" modified="2015-04-29" version="1">MNTSNDRVASTPSGCEDTLRMKRTGTRLTKTQIPVQVAASDAGQPQPQNTALLGSHEPPSPQLRTFSEVVSGKAPQLSATNYGESAAGQTTLGYEEQNHHERHQGHHTRAFRAKETSTWEEDFPSLPSKATPPQRHYHTTTHKALSNSGAAIPFPGRAPSNKPVDSSRSGATHSRKGRHEEQIQIYEVDREPEVKPFRFDEYDLRLRCRKPDCRKMTSCWDYSVVICPGCGPNSYVRYCSRQHLYDDIQYHWVYHCGRHRITDNIERTTIRPHQNPHRPYALGKGFNSVERHRQAVYRSLEPGDFFLFDDVGLLKPDFIEPTPEQWYLMRGTGPCVFQLFFPDDMTNESRRNVFNTTILECLGVGFPRAEKSCLTALHLVRESFILTGNWTEQMLNLLCLQLAGEWGGFKVPESFYNVKAANLAWRRHRILPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAT5</accession>
    <name>A0A0D2BAT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235926.1">
        <property type="nucleotide sequence ID" value="XM_016380099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAT5"/>
    <dbReference type="STRING" id="91928.A0A0D2BAT5"/>
    <dbReference type="GeneID" id="27332843"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05760"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_0_1"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="34"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="422" mass="47267" checksum="315EE83234F9CFD3" modified="2015-04-29" version="1">MSEKYAPAKRVAGQKQDVWSIVNEAAAASPVQPIVNMGQGFFGYNPPQFIIDAAKGALDRVECNQYSPTKGRPRLKKALAKAYSPFFGRELDAETEVTITTGANEGMLSAFMGFIEPGDEVIIFEPFFDQYLSNIEMPGGTIRYVPLHPPADGAEKTSSAANWRIDFDELERAFNSKTKMIVLNSPHNPVGKVFSKEELTKIGDLCLKHNVIILSDEVYDRLYYVPFTRIASLSPELAKITLTVGSAGKNFYATGWRVGYLIGPPELIKYVAAAHTRICYSSVSPLQEAAAIGFEVADQEGFWDQAVTEMKGKVDRFCEVFDELGIPYSIPEGGYFVLANLKRVKLPDGYTFPDHVKDRPRDFKMSWFLIMELGVAAIPPTEFYTDERAHLAEDWMRFAVCKNDDVLEQAKERLRGLKKYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAW7</accession>
    <name>A0A0D2BAW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinamide riboside kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235961.1">
        <property type="nucleotide sequence ID" value="XM_016380134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAW7"/>
    <dbReference type="STRING" id="91928.A0A0D2BAW7"/>
    <dbReference type="GeneID" id="27332878"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05795"/>
    <dbReference type="HOGENOM" id="CLU_058668_1_0_1"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="45807" checksum="728ED8DBEF98A243" modified="2015-04-29" version="1">MHTLPNDSPPPEENPAQTTASQVPLSPSRTIVIGLSGPSSSGKTTLARLLRSVFNVDVGGRVEADVDGKAKAKAPGREEKMKEATEDEGYHKLSLFILHQDDFYKTDKDVPWVTISSSKYGTRTDQDWDCVGSLDLPLFRRTLTHIRDHGTLPPDNVSMEDQNSVGDVHVTPDEVEAVKRRVKDWFERVIRDSPKSSKTRTLTRTNGAATATTTAAHEEVPREIRICILEGFLLFPPSPSDSSASFKTAAQGLAGDETTDLLELHDLTQSLLDVKLFLPCTKAQMIERRERRTGYVTLEGFWKDPPGYVEDLVWVNYRRYHAWMYRDHADNGDGDGEGEGEGEGGRKEEGHHQERDTDKSEASEEFDEEKCGREGVHLFLTHEKGVGEGTMKECLDWGVERVQEALTDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBE7</accession>
    <name>A0A0D2BBE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_06384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236549.1">
        <property type="nucleotide sequence ID" value="XM_016380722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBE7"/>
    <dbReference type="STRING" id="91928.A0A0D2BBE7"/>
    <dbReference type="GeneID" id="27333467"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06384"/>
    <dbReference type="HOGENOM" id="CLU_383574_0_0_1"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="135"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW16333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="721" mass="80920" checksum="71D944FA4F4E95D8" modified="2015-04-29" version="1">MGVEPSSSSCVSTQLEWDTRTVSKARTSISCCSVSSVVANGMDVTMPPVGDLLPSCYYIPSFINRAEEDRIIKDIRKVPDSRWTVLTHRRLLSLPSTLTGPARDTLLDAPLPSYLASVVARLKESRYFTDSTHQQPNHVLINEYKPGEGIMPHEDGPAYAPITATVSLGSHTVLEIYKKNDVGEREAQPSWRILQEPCSLLVTTGHMYAQTLHGISEITVDENLNSDHIVNWDLVEEKGAYQSGKAGRGTRISLTFRDVTKVAKLGGAMKFMSKRSLLQKGRSSCWVLAAGQIRRCRRLRRARKVNDGRGAMTEYHKPFTAAELQSLDIVARVTACLSLAGSSFTIISFLSYAPLRKPVNRLAFSIAISNVFGCLAYSWGRHPVAAGRHSAWCQTQGLFITWFVMTDPLLVMVLAFNVFLTVRTSRNANRLKTIDFYGICFAFVAPAIPAFVFLCWRPDGKTVYGDATLWCWIAREKDILRLVEFYIPVWVMIFTSICLFALSGKQILQVRKKLKIASCKFDSREAVCSPEARERRFSISARAFISRTFSTDSRIPPSLSTNSFKPEVEHVTIERVVPVHSREELDPNDVLPNMIMTTTTTTMASTLPILDPSSSEKGRSRAKTASRFDKIHWKYAKFAFLCTVVLFITWIPISINRVYNNFINPDHQIFGLYFASALCMPLHGFGNFVIYTTTSWTECRDFITCSGHRSSTRNSRRSSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCJ7</accession>
    <name>A0A0D2BCJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase-like Early set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236566.1">
        <property type="nucleotide sequence ID" value="XM_016380739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCJ7"/>
    <dbReference type="STRING" id="91928.A0A0D2BCJ7"/>
    <dbReference type="GeneID" id="27333484"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06401"/>
    <dbReference type="HOGENOM" id="CLU_009630_0_1_1"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="3">
        <location>
            <begin position="224"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35916" checksum="35BA3133AD3392C9" modified="2015-04-29" version="1">MYPFLHLLPDGSLFIFADRSSETFDVTSSRTIETMPELPGLHRTYPNTGGSVMLPLHRSNNYEPEIMICGGGQAQAVDSLCDATCGRLRPLSSKPKWQMTSMPEPRGMVEAVLLLDGTVLWLNGYQQGAQGFGLATEPALEALIYDPEASKWSVHGKSRIPRLYHSVALLMLDGTVLVASSNPNEMPVTIDQVDGNDQQKAFPTEFRIESYTPVYLKGNNASRRPTDVKLLDRTFAANSSCEIEFSSVEDVESLDIVLYSGGFVTHSLHMGQVMVYLEHSSWETSNAGRTKVQAYMPDGVKIAPGPYVVYIVANGVPGIGQFVTFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BD52</accession>
    <name>A0A0D2BD52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_04083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237109.1">
        <property type="nucleotide sequence ID" value="XM_016378432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BD52"/>
    <dbReference type="GeneID" id="27331166"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04083"/>
    <dbReference type="HOGENOM" id="CLU_000960_25_3_1"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="592" mass="62832" checksum="5189A16A1FF64574" modified="2015-04-29" version="1">MGEDAASRTKEGPSSERIEISRHGVTRLRIDTNDDSHAVQGDNSDGAIEWTLTRFIAYLSLAGLYVGAQIPLYFVGASLSFIVKDIGSPEKSAWLPVANTLAIAAVAPFVGYLQDIFGRRYMSMAGGVSIIVGIIIVGTSHSFGQAVTGMAFAGAGGAVGELTALAGTAELVPVKLRGLYLGLVTFFVIPFVPYVMYGQLLSTYHTWRWGMWISLIYNGIAFVGIALTYFPQAARRGDGASKMQILKSIDYVGGLLSIIGLTLFLVSLQAGGYSHPWSSAYVLCNLLIGIALILGFVVWEWKFATNAIVPPELFKGRRTVAVSFLVAFVGGVNFYSSLNFFPLESSTVFDPNPVQVGLKGLAAALGVTLGATVVNSALSWLRGYNRELLVGSCILMTAFGGALADLNPDSTAKLYVFVVLSGIGIGGVLVPAATIAITVAPDELIATCVALSLSIRVVGGSIGYSIYYNIFYQKLVHHLPLAVAEAAIKAGLPITSAKQFVETFLLNPAAIGTVPGVTPAVLEAAAIGSRWGYAYALKYVWYTSIPFGICAIIACLFIGNTEKYMTNRIAAQIGHSVKEKNIKEEPLASGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BD53</accession>
    <name>A0A0D2BD53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">P-type ATPase A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_06565</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236726.1">
        <property type="nucleotide sequence ID" value="XM_016380899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BD53"/>
    <dbReference type="STRING" id="91928.A0A0D2BD53"/>
    <dbReference type="GeneID" id="27333648"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06565"/>
    <dbReference type="HOGENOM" id="CLU_001771_10_8_1"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="11">
        <location>
            <begin position="80"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW16510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="608" mass="65436" checksum="2754344D37D24954" modified="2015-04-29" version="1">MNSLISFSTVVGLLFTVLDILAVGPLRSTSYAMTTSGLTLVVVAGRYLDKLSRRQASKHLVKLYEGLSGRDYVKLHPSGKKVPSSFLRPGDTIKLDPFCVVPCDCYVVQGTSTFNQSLVTGEALPITKSLGDFLLAGTKNLNGSLLCIVHREREESFYAQLVRSVSEAGANKIKGQGMIDAVTRWFSLAVVLLAIFSPPLELFYQQKRHPVGFYVGLSRFVERIMTILVSACPCALGLAVPSAVVAAIDAAHSKGILLTKGASTLRELEQVDMIVFDKTGTLTEGAFVVESVTLHPTWDGKEIMLWTLVCTLEEQEANGHPVGVALFKKGLQEIGTRWLDSVDRPKICETATVPGRGVVGKIGIEDAHGSSSWYRVLIGSQEFLRENSVAPCWDTSPATPPLSGIAVHIGINGVLVATLYLQDRIRPEAGETLRNLVDRGYGVAMLTGDAEAEASRVGLQLGIPVLAFRASPSDKLRHIRSLQKAGSKVAMVGDGLNDAPSLAASDVGIIMTCNSSAATVGGSVMILNSDLACLQLLGTIVQKTMRQIRWNVIWAFCYNLVALSLATGMVRPLGYTLKPGSFDVNFVRHNDHAITAIEETATGGWAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEA7</accession>
    <name>A0A0D2BEA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_04115</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237141.1">
        <property type="nucleotide sequence ID" value="XM_016378464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEA7"/>
    <dbReference type="STRING" id="91928.A0A0D2BEA7"/>
    <dbReference type="GeneID" id="27331198"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04115"/>
    <dbReference type="HOGENOM" id="CLU_034866_0_0_1"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="120"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW16925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="431" mass="46995" checksum="5BD89532C1E8F93C" modified="2015-04-29" version="1">MPSRAEVAYFGAGPAPLPTPVIEESAKAFINFEDTGLSLAEISHRSPTANKILADAKQALTALYDIPDDYDIFFMQAGGTGEFSAACQNLVGCWIEQRRRKAVADLGEGKDDEVLARVKKEIENELKLDYLVTGSWSLKASQEATRLLGAKYVNVALDARKGNNNKFGKIPAESEWKLTPKGSALTYMCDNETVDGVEFPSFPKSLEENDRIVVADMSSNFVSKKLDVSKYSVIFGGAQKNLGIAGIAVVIIRKSLLSLVPPPTFLHRLSDVLPTSGALPPIMFSFSTIAANNSLYNTLPIFNLYVATLVLQSLVSTFKTVSGQEEVANQKAKLIYDTLDAYPDLYHVVPDRNVRSRMNICVRIIAGRSEGAVTPDDAKEKAFLAGAEKRNLLGLKGHRSVGGIRISNYNAVPVENVQKLVQWLNEFAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEB6</accession>
    <name>A0A0D2BEB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_12023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847503">
        <property type="protein sequence ID" value="KIW09739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229955.1">
        <property type="nucleotide sequence ID" value="XM_016386330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEB6"/>
    <dbReference type="STRING" id="91928.A0A0D2BEB6"/>
    <dbReference type="GeneID" id="27339106"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12023"/>
    <dbReference type="HOGENOM" id="CLU_037030_1_0_1"/>
    <dbReference type="OrthoDB" id="4364447at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW09739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="358" mass="41777" checksum="53F9EE65ABFF6E37" modified="2015-04-29" version="1">MKKKAIITDTEQDVVLSPAVYWEKCLQPRLEERLSKKGYPPRSVRVEETEVIVSVTGRTGRPLTRQFDDLRVEWSVVERQLTEWSELFQKGKKLFVKIRIRYIEVNPLISTNSGATRPTKVRGTATQHMLAERAAQIDAEESTTSNPSAWRYVYALMRCPGPPCVKHSWCWHDTQTQKRYTLKGHHLRTLVRYVEDKNRLESHDDIPDSLRQQIYAEEEQYMRKKRVDRGSVSFDRAPIQITNVLPPQSSTESETMQRPETKRLDITGLHDVNVQDYCDWLKSRVKKESHKHEYQKAADFLLDKAFDLDLVYEDQNPTFLIEQGGVEEGIARRFVKDIPLWVKLCKQNNVEADSVLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEU5</accession>
    <name>A0A0D2BEU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237694.1">
        <property type="nucleotide sequence ID" value="XM_016379017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEU5"/>
    <dbReference type="STRING" id="91928.A0A0D2BEU5"/>
    <dbReference type="GeneID" id="27331755"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04672"/>
    <dbReference type="HOGENOM" id="CLU_003963_1_0_1"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000028">
        <property type="entry name" value="WW domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF2">
        <property type="entry name" value="WW DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="450"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1173" mass="127377" checksum="C5FDFAC795235C10" modified="2015-04-29" version="1">MSVPGHQGRPEGEMFLNRPSGRDSPTIVEPLRINKRTASASSSVSSVAGKQSPVPQQPPQSTTVYPMPSLPYPDERPRQQAQSSRINGNPVSTPYPYPDVRRVTSPEQAGSRQPGQRRPSGGGQTLAERRGTMPKPLPESPGPDAPDKEGLFQRQPQRGDGPATAPLPGSQSQSSQQYWPPPSASSAADALSRLKIRDPGSINRISSTASTSTTRAQRGSPPPPETPISGPAARPQTDIEARYAASGIAGAATLNSLQAQSLAAQQRAAQYGAPAQQQNDQPRRPWTPTEAPGSSPHPPPTVYQGMGIAQSSPPTASAAPVVQQPTVSSPGRNPYPVENEISRLQPHEEPPPAYSQVSGPNGRRPPEKHRQSMVGAGAPATGTPAPVPIAQTNTVPGAQVPNQQGHPAFANDPRQHNQSPASAAAVNGQAQQTQQHAQQMPAQIPPASPPPLPEGWIAHLDANSGQYYYIHLPTQATQWEFPKGPTPLNLHETPLSPVGSVYQNPLSSPGLSFSQKPLASPGLPLTPGYDQQSVMNLSNPAAFTGPPPTSGIDIYKVVATNGVYFGPYLRYTNMDIDRGIWYGSILLVTDAPQPPTIHIHQSIDLSPNPRQLKAANISQHQRWTFYKYEIDLQMEESGPAKWTYAITSHLGCTRYEFLVAGKHETNWRFIATSGNDFTLNVSANERARLGGVGFMWKDIMQKHAECGGFHCQLGLGSQIYADRMWKEIASLKQWLATSGKENRKNAVWTAAHEEDVTHAYFHYYTSHFDQPYLREAFAQIPHVLTLDDHDIFDGFGSYPEYMQFSNMFKNIGRIGIEMYLLFQHHTTLEILRNVSDDHDLFTVTGTGWHFVKFLGPAVAVVGPDTRSERNPHQVMAGPTYQGLFPKIALLPQTIQHCILMIPVPLIYPRLDAAEQIAHTMATGKKAVTGAYNVLGKVTSSVAGVVGAKGAVGSGFDSVKRAVGKSGLMGGILNPFGDIDVLDELKDQWTHESKDLERTYFIRTLQGISHQRSIRMTFISGAVNTCGAGLVHDPSHPSDHKTMYQLISSSVVNTPPPSYVMKLLNNNKPLYIPPNGQRSTPSQPTDTKEDMMEIFTHDVTGQGMNNRKLMARRNYVAIVVYDPEIVNGTFGSTGMHRGGGRLSLATDFLVQGEGAYGNVVKYGPVVVPSLEFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFJ7</accession>
    <name>A0A0D2BFJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PV08_04574</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237596.1">
        <property type="nucleotide sequence ID" value="XM_016378919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFJ7"/>
    <dbReference type="STRING" id="91928.A0A0D2BFJ7"/>
    <dbReference type="GeneID" id="27331657"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04574"/>
    <dbReference type="HOGENOM" id="CLU_000022_46_3_1"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000020">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF6">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY PROTEIN (CEFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="58"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KIW17380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="630" mass="71173" checksum="EA7C124ECFE4EB3C" modified="2015-04-29" version="1">MALATAAAVAAGSWATAAYLDAKFHLRKDYDNIARMSQGAKEYARAVKEDRVSFWYVLEERCKQYESRRAIWWRERSYTFGELHDETLRIAQWMLEQGVRPGELVALYLTNSPHFMFSWFACLAIGAAPAFINYNLEGKALLHCLDVAQTKLLVVDDEPGCQARIEGSRTDIESRGMRIAVLDDALKQSISSRPVVRPGDELRAGTKGEFPYCLIYTSGTTGLPKGCAFTHSRVWLMCGHSMPICDGKPGVDRWYNSMPLYHGTGGISSSTSLLQGLSLALAPKFSVSRFWNDIHDSESTFFIYVGETARYLLNAPAHPLERDHKLRVAYGNGLRPDVWAKFQERFNVPEIGEFFNSTEGMFSLFNYDKGPFLQGCVGHHGLLLRTMLRNVYIPVKIDHDTGDIWRDPKTGFAQRTPYEEGGEMLVAVPNKEAFQGYWRSQAATDKKFCVDVFKKGDVYYRSGDALKRDADGRWHFLDRLGDTFRWKSENVSTAEVALTIGQYPGIAEANVYGVLVPNHEGRAGCAAIHLDPNHQGPPVNWDDLLKFTRARLPRYAVPVFLRVVKASTHIHNHKQNKVPLRKEGVDPNLVGTEAKEGKDDVFLWVPPKGDSYVPFTRQDWEKLENKEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFZ1</accession>
    <name>A0A0D2BFZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_11251</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230505.1">
        <property type="nucleotide sequence ID" value="XM_016385561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFZ1"/>
    <dbReference type="STRING" id="91928.A0A0D2BFZ1"/>
    <dbReference type="GeneID" id="27338334"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11251"/>
    <dbReference type="HOGENOM" id="CLU_035117_6_1_1"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="193"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW10289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="335" mass="35888" checksum="CE56863EF453A2BD" modified="2015-04-29" version="1">MPDTVQNGTTATAIPHAVYGFIGLGNMGFGMAKNLRACMPKHSKLLVCELNITRGQQFVSSVDGLVEAVECPKDIAEQCDIIITSLPHGDAVRQVFTDPSTGLLSVSPHSGTRKFFLETSTIEVRTSNEVLEAVKRAGVGDFIDCPVSGGIPAADQGNLTFMVGGTQELLDRAKPVLATMGKAENVIFCGPAGAGLATKQINNYIANVSYIALCEGMNTGIKYGLDPKVLTDVINVSSGMCWNSLHMNPVKGVQPDSPSSRDFEGGFKTELAKGVMDMTVQLMDDVGAKHVMGPIVTDVYARAVKHPRCADKECRSIYRLFSENEGRDLGNTRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BH62</accession>
    <name>A0A0D2BH62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238171.1">
        <property type="nucleotide sequence ID" value="XM_016379494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BH62"/>
    <dbReference type="STRING" id="91928.A0A0D2BH62"/>
    <dbReference type="GeneID" id="27332233"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05150"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="4133411at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="285" mass="30427" checksum="CB37617D58CD2059" modified="2015-04-29" version="1">MSLQLNGVAFVTGAGSGIGQACVQQLVRDGCSRIVATDINREGLARTKAMGESIRADVHIVVDAGDITDAHTVERLITLTVSTFGRLDYGLNIAGITGAQNLIPLLQPEQYDEVQHINARAVWLCERAEIAQMLTQEPLPSHDGRPGSKGSIVNVASICGLVGFPNSTPYTMSKHAVIGLVRSDSTTFANQGIRVNALCPGIIDTPLIKPEHRQFSLDYAQRFTPMGRLGTAQEIADVATFLGQPTSLARSLPLMVAIRLNSVEIYTNAIGQCVSIEKRLHGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHA6</accession>
    <name>A0A0D2BHA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230950.1">
        <property type="nucleotide sequence ID" value="XM_016384348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHA6"/>
    <dbReference type="STRING" id="91928.A0A0D2BHA6"/>
    <dbReference type="GeneID" id="27337116"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10033"/>
    <dbReference type="HOGENOM" id="CLU_008719_1_2_1"/>
    <dbReference type="OrthoDB" id="4116205at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="597" mass="67342" checksum="12358F664668F032" modified="2015-04-29" version="1">MRARTGCQPCRDRHVKCVKPVGSENCIRCLQSHRSCVSETPLQFRPVKSIHLKTTGGRRVRQDLRNSPRQIWVDVPADGRSHDQEQDQEHDDEYEQQHEQEQEQEQEQEQGILDAIQVVPTGKLSISSPTSAISNAQSNNQPTSYAVPRQTSVTFHQGSSPQNLLFAGAGFASALRNHSPQSHFSSHTPLAIGYSPSEPAERSSNLNPSPALLRAGSCVTSPSLLSGSWPFQNRHEARLMHHYIVNLSLQFDSCDNLMHFFKEVPRRASHHPIIKNAIFALSSLHLCRLSGLEDHESHVYVNECLQTLIPALEDPLSHLDENLLAAVILLRTHEEMSDNDTCCHLLGVTRILNSIASFAADGGLRESASWISLRQHIYVALTSQGPLTINLTNYRHSSVFQRPDDEAWANRIIFIFASILTQIFLPDGERLSLGQWDELDAQVTTWDSSKPWHFSPLYMEASSQTPSSLDRKWSFWPEAWVCVPAQVVGLQHYYLARIILAIYDPRLSRLGFDSYKLRRSLEDIVRQNLRMVIGLAASNSHVLTGMFHASHALSACGMYLTDPQEQQAAVEFLESMETSMGWRTQHIIQNLKSQWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHR5</accession>
    <name>A0A0D2BHR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_10218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231135.1">
        <property type="nucleotide sequence ID" value="XM_016384533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHR5"/>
    <dbReference type="STRING" id="91928.A0A0D2BHR5"/>
    <dbReference type="GeneID" id="27337301"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10218"/>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="OrthoDB" id="4158009at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="233"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="427"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="510"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="552"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="594"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="633"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW10919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="782" mass="86960" checksum="3770C14CDB586AF0" modified="2015-04-29" version="1">MSKSIVNKAILSYFFCQATDSRVNNAVAVLRGLIYMLVCQRPSLISHVQEKYKHAGKDLFQDQNAWIALSEIFTNLLQDPSLDNTYLIIDALDECVEGLPKLLGLIAHMSSASRVKWIVSSRNWPSIDKDLDPATLKVRLCLELNEKSVSAAVTTYIHFKVDWLAKRHRYDSDTRDAVLRHLSLNANGTFLWVALVCQELADISEWDDAEEMSKAFPPGLNPLYTRMLDQIGTSKYAKLCKSILAVVSTVRRPITLDELKSFVDMPARRSGNSSALAEIIELCGSFLTLQERTIFFVHQSAKDFLVKERYNDIYPSGREHIHQSIFWRSLQLMLDKLKRDVYGLGELGISIDQVKQPDPDPLSPARYSCVYWIDHLLCCDHASNDLRDGGSVDKFLRQKFLYWLEALSLCRSMSNGIVSMAKLETLIQGHKHRVISAAFSHDSVQLISASADGTINIWNANSGDCLHTLKDNVSTQSVVFSHDSRWLASASIDGTVKIWNASSGKCLQTLDGHGHWVNSVAFSHDSARLASGSDDETIKIWDTSSSEGLQTTEHHKQHVRSVAFSNDSILLASAAGDNTVKIWDTRNMKCLHTLKGHNDWVTLVTFSSDSTRLASACLNKVIRIWNVSSGECLQTHDGFVMSVAFSPDSTRLASACLNKVIRIWDASSGECLQTLNTGKILSNISFDITGSYLCTETGTIAINAPSVSIMAPSVTDPHSPPYQSLALSPDKEWITFGSKNQLWLPPEYRPAFSDTVVVAGRMVGIGTRSGKVWICNIELDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHX7</accession>
    <name>A0A0D2BHX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238729.1">
        <property type="nucleotide sequence ID" value="XM_016377159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHX7"/>
    <dbReference type="STRING" id="91928.A0A0D2BHX7"/>
    <dbReference type="GeneID" id="27329884"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02801"/>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="55"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="292" mass="32020" checksum="2F18F85154A5EE85" modified="2015-04-29" version="1">MAPPTATETITSPVMGLDEPDTAPSEPAPPTAHYQKFPGPPRFTDKYEEREYLKGRLALAFRIFGKYGYDEGVAGHITLRDPVDPHTFWVNPFGVAFSEIKKSDLILVDHEGKVIDGGPCRLLNTAAYMIHAAIHNARPDVMCAAHSHSIYGRTFCTLGRPIDITTQDSCIFYNDLAVYKQFKGIVLAKEEGENIAKAIGSKKACLLQNHGLLTCGQTIEATVFWFVSLEKLCHTQLLADAAAAGRGGETVKIDEEDAAYTYKSVGTPRAGWFSAKPMFDVVAKECNGEYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BI78</accession>
    <name>A0A0D2BI78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_02613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238541.1">
        <property type="nucleotide sequence ID" value="XM_016376971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BI78"/>
    <dbReference type="GeneID" id="27329696"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02613"/>
    <dbReference type="HOGENOM" id="CLU_108992_0_0_1"/>
    <dbReference type="OrthoDB" id="5407417at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15033" checksum="15E41B826F020196" modified="2015-04-29" version="1">MEGPSFEPIEISFPLPKHPHLNFHAHMSPLGTCVMVHLTTTDLDRSQTSLPPLGSFVYAMPNLRSDGDIISTPLATSGSSIDYATRMAKVLARRMRQPVYVGCSMNFAGTTTEEEMEGFTVAVSEIMRQWNERRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ89</accession>
    <name>A0A0D2BJ89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_10709</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231625.1">
        <property type="nucleotide sequence ID" value="XM_016385023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ89"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ89"/>
    <dbReference type="GeneID" id="27337792"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10709"/>
    <dbReference type="HOGENOM" id="CLU_007565_1_0_1"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000022">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="13">
        <location>
            <begin position="305"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="15">
        <location>
            <begin position="578"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="813"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="840"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW11409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1180" mass="131624" checksum="46DEC48EACA0FFBF" modified="2015-04-29" version="1">MGTLIDRFEEHDGPVRGIDFHKTQPLFVSGGDDYKIKVWSYQSRRCLFTLNGHLDYVRTVFFHHELPWILSASDDQTIRIWNWQNRSLICTMTGHNHYAMCAQFHPKEDLIVSASLDQSVRVWDISGLRKKHSAPTSMSFEDQMARANQQQADMFGNTDAVVKFVLEGHDRGVNWVAFHPTLPLIVSAGDDRLVKLWRMSETKAWEVDTCRGHFQNVSACLFHPHQDLILSVGEDKTVRVWDLNKRTSVQSFKRENDRFWVIAAHPEINLFAAGHDNGVMVFKLERERPASSVYQNQLFYVTKDKHVRSYDFTKNTESPSLLSLRKFGSNWVPPRTLSYNPAERSILVTSPSDSGSYELIGLPRDATGASDPTDIKRGSGNAAVFVARNRFAVFSSSTQQVEIKDLSNSTTKAFKAPTPGTTDISYGGTGCLLLLSPSNVILYDIQQKKQLAELAVAGVKYVSWSNDGLYAALLSKHNVTIVNKNLEQVSTLHETIRIKSATWDDSGVLLYSTLNHIKYTLLNGDNGILRTLDQTVYLVKVKGRNVYCLDRAAKPKVLSIDPTEYRFKLALVKRNYDEMLQIIKNSSLVGQSIIAYVQKKGYPEIALQFVQDPQTRFELAIECGNLEVATEMAKELDRPKIWTRLGAEALIHGNHQTVEMTYQKLRNFDKLSFLYLCTGDQEKLTRMAKIAEHRSDFVSRFQNALYLGDVESRIQMFKEIDLYPLAYLTAKTHGLTEECQSILELCGLTEDQISMPESGKALVPPKAVVPTYKANWPVKEASHSSFEKALLGEVGGTVEDDDGHDLLNEDVPTTADGAGLTIEDEAEAGEGWDMGDDIGLDTTGDDSEFVNVDSPDTAVEAAGPGSSEAEMWARNSPLAADHVAAGSFESAMQLLNRQIGAVNFTPLKPRFFEIYQASKTYLPANTGLPPILNYVRRNVDETDSRKVLPIIPKTLDSLSSADLQEGYTAMRTNKLESGVVTFRTILQKLLVNVVSSEAEVDEAKALIAKSMEYTLAMSIELERRQLATAGGDSEEQLKRQLELSAYFTVPKLDVPHRQLALMAAMKLAFSNKQFSSALSFANRVLANGGAPKLLEQAKKVKQQAERSGSSDKIDIEYDQFAEFEICAASYTPIYTGSQSVSCPFDGAKYQSQYKGQVCKICEVCEIGAAASGLRLWVRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJN6</accession>
    <name>A0A0D2BJN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239339.1">
        <property type="nucleotide sequence ID" value="XM_016377769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJN6"/>
    <dbReference type="STRING" id="91928.A0A0D2BJN6"/>
    <dbReference type="GeneID" id="27330498"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03415"/>
    <dbReference type="HOGENOM" id="CLU_015161_2_1_1"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="586" mass="64759" checksum="1E34D483B5B584D1" modified="2015-04-29" version="1">MVALYRQHCHRQPVWLFSDAELESLSEQPEELLLAMLAITTRFSESAHFRDKNRNDMSQRFGDAARNLVMLKIANAGVGLGTIQSLCLLAWAGFAGGNNMLTPTPWGKTARDTFLAPLHLNLARDLLRSAGLDLRSHALTPADQPTKRLFWSIYLLEQLYGTQGSRVISLRDGLDNIRYCVTVGEHARRALTLEPPQIPDDASVDGDSLDHGIWSSTLCLSTLWNEVRNYIQLCASDFERAPWAPESYYTLIGSYMHELETQLPQPHRSNGKQFSQCPPAVLEQERSYWAPWVFLQLSYHGIYTVINHPFLLTSRLQSLRLKIPNTFWGRSAEAALVHSTWVCRLITMVQGKGFDLSDPFLGYIVGVAATAQLFYSCSQNEELSRNARESFDKCMAFLDGQAAVWQWCRGIKQNLELLASQAFDGGTTSRVISIDTTLMLDIFDYSRCREADHPAMSASTGDGPGHRLFDGSLSLRGDRIGSQLATMEMSEDPSDAAAGRPVAPPVWRPASASSGGGRGGDGRSGGSDVEMIPDSGATPTHNPIRQSAAEVVHADLELFALPAEAFSDGLLQNIFGSESDWWNVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK09</accession>
    <name>A0A0D2BK09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kelch repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239131.1">
        <property type="nucleotide sequence ID" value="XM_016377561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK09"/>
    <dbReference type="STRING" id="91928.A0A0D2BK09"/>
    <dbReference type="GeneID" id="27330287"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03204"/>
    <dbReference type="HOGENOM" id="CLU_012508_0_0_1"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="655"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="777"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="783"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="867" mass="91284" checksum="B6EBAD28FEB903DA" modified="2015-04-29" version="1">MDTEQGAEKRRVTRMTSHASRLSGQDSSVFGLSYSTTPALVPARESSSNEPRRRQSFVPASQNTAPCDDDIIAALEEEEPLPAVRRRNSAFLEVGLGGDDAIVDAKLSDTTTTTTRPRLQVRFRSTVDVFEPDPPLSTRDESFPPAPTARDKPPQMPFAFPTLSRLLFLALVAVLVTQSLHTTPILKADANPVGPRRDGLLARDTPRQDKRALPGANVKRDNSPTVVCKRWAGQSALVNGTLYYYGGRSTTSGDQTANEWNNDLVAIDLTKSWQISTPSISGLPIPSGPPAVSLGYLWNSYDALYLYGGEFSDSPAESPVPFSTWSYDVSSSSWTELSNPKTSAGDNSEPAGQPVQRAAEGAGVSVPNIGRGFYFGGHLDGYTTPGWSQSVARVYIKGLLEYTFPGYTNDAVSDSGTAGSSGIYRNITEGGVQDTSGFPERADGVLVYVPGYSKQGIIIGLAGGTNATFTQMNVIDVYDIAASKWYKQATSGPTPDIRVNPCAVAVSAADGTSTQVHMYGGQNLVPYGDQIQYDDMWILTVPSFTWIKVDTSDQATPGPRAGHTCNVWNAQMVVVGGYVGQDQGCDSPGVYVFNTSSLSWQNEYVALDSRDDLNRQESQRDDAAALQGSYGYAVPPAVQRVVGGNAVGAATVTQPAQTATQGPLMTGQPLTYSVTGAPGASGTSSPTSGGGSDGSGNGSDSSSGGGGGATNVGAIVAGVIAGLFAVLAAYLGFCVWLYRKQLRIYKNHSDMAQRQHLSGDPRYIGAGAGGSAAASEGVAAQKYTDKSQTDSRNSADNHSGDGSTTGARSTSARANQLNSNNPYRNVAGGAGSATAASSTEDLMAGQEPSFLGVVLNPRRSLRVVNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKC4</accession>
    <name>A0A0D2BKC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231950.1">
        <property type="nucleotide sequence ID" value="XM_016383327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKC4"/>
    <dbReference type="STRING" id="91928.A0A0D2BKC4"/>
    <dbReference type="GeneID" id="27336089"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09006"/>
    <dbReference type="HOGENOM" id="CLU_006524_7_2_1"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="650" mass="72415" checksum="B4371DE518ED9B72" modified="2015-04-29" version="1">MNAIGNGQLKQRACVRCAAAKAKCSFNGSDKFCERCRRLKRECILEDRPRRKKEKQSSRVKALEEKVETLLSMMGPEKGGMGVPTSGPRIDLETPAPTDDDSMKSVASSTFEPGHRFDIINTGLLTIAAADIILEKYKCVRTKLFPFVVVPPEIDAATLREKSPFLFLAIMTAGIEGDHLLQRRLGVECRKILCERVMIGADKDFDLLQGLLVHLGWSHFHFSPAKKQLYMLFLTAYGLVIDLELDRCPAHRDQRVASAICCHTVVFGQPKTLPAQCRRSTAEIRALFGCFYISSSLAVMRKELAMTHTKWIDNCCKILEAEQEYPTDVDAVAFIRAKCLVKTIGERFSYSDPALVRSHNDSVLQMSLNGFKKEIADLEASHALSAANTNYALIAEIQALPVTLYEIALYRDHSNTSTPSQTSNLWNLLTSARDLLTHVLEIPKEIITELPSGFFNLFPYALVVLSIVSRMPTTSAWDHAIASREADFMDFTQRIQTKFGTELSTTTPDAEPDQRDVWQFFSRGLSGLSTWHQRCESTSSAEAEIEVSLVSPYHTMKCAMADTMTAFASMRFQKTTQHSCGAEHEAQPVVQLYGTTEPTSGTATGNYNHQSQQDMLGSSIGDNMMWQSIIDDFSMFPTTTGFPGAPPVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM84</accession>
    <name>A0A0D2BM84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_00583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240224.1">
        <property type="nucleotide sequence ID" value="XM_016374948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM84"/>
    <dbReference type="STRING" id="91928.A0A0D2BM84"/>
    <dbReference type="GeneID" id="27327666"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00583"/>
    <dbReference type="HOGENOM" id="CLU_046737_1_2_1"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="47"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW20008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="217" mass="24746" checksum="21E393EC46676406" modified="2015-04-29" version="1">MAFLYAYPDVDPYPTTHVAHTFPEKGHHLRHIPIPYLAHKAHKIFHDKDQDVHVPRTDVRETPKSFYVEVELPGIKDKTELHLRWTSTRTLLVTSKITRPEIPESEMVYDPDTEGILEPTPTEEEREERPVEGGEAKKEEETPAKLEPHLTVHERLIGDYMRAFNFPVDVDRDETHAKLDAGLLKVIVPKLTHGTAISRHVSVNVHDGDSTKEAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMQ9</accession>
    <name>A0A0D2BMQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_00803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240444.1">
        <property type="nucleotide sequence ID" value="XM_016375168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMQ9"/>
    <dbReference type="STRING" id="91928.A0A0D2BMQ9"/>
    <dbReference type="GeneID" id="27327886"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00803"/>
    <dbReference type="HOGENOM" id="CLU_013364_5_0_1"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254638" evidence="3">
        <location>
            <begin position="20"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="212"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="436"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW20228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="589" mass="62942" checksum="955CD00247208A1D" modified="2015-04-29" version="1">MRAVFIFVATALGIKLAAGHASLRANVHARDVCIDCHTDAFPPGPPSGGGRGGSQIRWTDQCTELAAVSAMPFQCAKLNVPLDYTRLDSENLTLTLVRVDAVKKPARGSIIFNPGGPGGSGVQTVIANAKSWLILTGGHYNLLGELMLTISRGVNNTLPFSCDIPGDTCKTMSPACPLANASDVAIGQRFAASGVRSLRCLDRTQDTGSLLGTAFVARDMVRIIDALNEDGLLRYYGFSWGTILGATFAAMFPDRVDKMVLDGNVNVHEYYSGWEVQSPINMDDTYDAIFSGCVVAPTVCPLAELYSKTKQIQSVVDDFLAMLKYNPIPYISGGGIQIATYSKVKTAIVLALYSPSNWPRLTQGFIEMLSGNVTGFFDIASSWYAGPEDGDDDISAAITCGEQAFRAESVQGLKPLLGAMSASSKFGGLDFGTDNAFACSTWKQKAKEIYSGNFRVKPRSPILFVGNTYDPVTPLASALNTSAGFGGSVVLQHNGYGHCSIAQPSSCTAKAIRAYFDEGILPPAGAVCQPNAPLYPGDSRVGDWTNLSDRTVPEAIRQDSEDELALLGAVSEIAGTILPWLRKYHFRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNQ6</accession>
    <name>A0A0D2BNQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hsp90-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_00745</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240386.1">
        <property type="nucleotide sequence ID" value="XM_016375110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNQ6"/>
    <dbReference type="STRING" id="91928.A0A0D2BNQ6"/>
    <dbReference type="GeneID" id="27327828"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00745"/>
    <dbReference type="HOGENOM" id="CLU_006684_1_3_1"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="673"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW20170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="702" mass="80154" checksum="414B5F5E87E33BA2" modified="2015-04-29" version="1">MAPNETFEFQAEISQLLSLIINTVYSNKEIFLRELISNCSDALDKIRYEALSDPSKLDSGKDLRIDIIPDKESKTLTIRDTGIGMTKADLVNNLGTIARSGTKQFMEALTAGADISMIGQFGVGFYSAYLVADKVTVISKHNDDEQYIWESSAGGTFTITQDTEGEPLGRGTKMILHLKDEQTDYLNESKIKEVVKKHSEFISYPIYLHVLKETEKEVPDEDAEEVKEEDEEKKPKIEEVDDDEEEKKPKTKKIKETKIEEEELNKTKPIWTRNPSDITQEEYASFYKSLSNDWEDHLAVKHFSVEGQLEFRAILFVPKRAPFDLFETKKTKNNIKLYVRRVFITDDATDLIPEWLGFIKGVVDSEDLPLNLSRETLQQNKIMKVIKKNIVKKCLELFNEIAEDREQFDKFYSAFSKNIKLGIHEDSQNRQSLAKLLRFHSTKSGEDTTSLTDYITRMQEHQKQIYYITGESIKAVSKSPFLDTLKEKNFEVLFLVDPIDEYAMTQLKEFDGKKLVDITKDFELEETEEEKKEREKEEKEYEGLAKSLKNILGDKVEKVVVSHKLIGSPCAIRTGQFGWSANMERIMKAQALRDTSMSSYMSSKKTFEISPKSPIIRELKKKVEADGENDRTVKSITQLLFETSLLVSGFTIDEPASFAERIHKLVSLGLNVDEEAETSEEKAAEEAPAGEATGESAMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ08</accession>
    <name>A0A0D2BQ08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_01160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240801.1">
        <property type="nucleotide sequence ID" value="XM_016375525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ08"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ08"/>
    <dbReference type="GeneID" id="27328243"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01160"/>
    <dbReference type="HOGENOM" id="CLU_030430_0_1_1"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW20585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="55522" checksum="1122F921D1CB4D31" modified="2015-04-29" version="1">MKSRLTGMLKGPYRSIIGATIAIFLLLSLWVLPWRANFPVLNVAIGKGSAESMVDDARYASAAENATRMLAHPLDKSRFGEMGQRMKVLREWIRHKDTAQLSRYEQREWSKLIESVAVSLIPFIQAPNTQDDRPLSTLRSRFVPGSKGLVITTGKKRFRYACHLITSLREVLNSTLPIQIAYSGDDDLPQEYRDFITSLATDVSTMDVTSIFDDGTLDLPHGGWAVKAFAVLGSTFEQVMLLDADAVFLQPPEVIFETHPAYIDTGTLLFHDRLLWKGAYKDRHSWWEKELENTTLSETIRHSKVFMEGYAEEGDSGVVVADKSRLDVFVGLLHIAWQNTRDVREALTYVKGHGDKESWWFGLELTETPYAMEQHYAAIVGHVRVDQEGHEEDRVCSFTIAHVDAQSRLLWFNGSLLKNKEIDSESFDVPGEWMIDGVWEKGPSKQDLSCMSGAQVRRIDQNLVEILSRSVLRAKQVDEELRVKIPSSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ27</accession>
    <name>A0A0D2BQ27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_01612</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241249.1">
        <property type="nucleotide sequence ID" value="XM_016375973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ27"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ27"/>
    <dbReference type="GeneID" id="27328695"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01612"/>
    <dbReference type="HOGENOM" id="CLU_053570_0_0_1"/>
    <dbReference type="OrthoDB" id="244190at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000060">
        <property type="entry name" value="SNARE complex subunit (Syn8)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="204"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW21033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="294" mass="32167" checksum="52B2A46F116F5330" modified="2015-04-29" version="1">MSNPSQLLLLADHIKLSLLERQRAISLNLDPNPSQDSNIARSLESFREGIASLSSNPDSDSDSAAAATLSQLRSQYSDLARQFHGEPSTTTGPTTLSSPNDPSLQDDFARAQSHKSNDLSRSRSSNLRKKDGSPSTTTATTASHGAQAKNVRFHDNPSQESLDAEDEAARAALFPARYTDDDDRAPTPDPTASMDNVQIHAYHQQVIAEQDEQLDRLGESIGRQRHLAMQVGDELEGQIALLDEVDRGVDRHQSRLDGAKKRLKTVSQSAKQNWGMTTIIVLIVILVLLIVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQK0</accession>
    <name>A0A0D2BQK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233625.1">
        <property type="nucleotide sequence ID" value="XM_016382922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQK0"/>
    <dbReference type="STRING" id="91928.A0A0D2BQK0"/>
    <dbReference type="GeneID" id="27335680"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08597"/>
    <dbReference type="HOGENOM" id="CLU_030125_1_1_1"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF29">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="28"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="430" mass="47863" checksum="478F16015290C331" modified="2015-04-29" version="1">MSEGKVHSEGIYHGLPSFPQHEGKQYTALVLGSSGITGAYIVEILSKSPYWKKIVAVSRSRPHFALPDHVQHLSIDLLQDHEVIGKTLSENDVKADYVFFSAYIQPPTAPGEGLWSNEQELERLNVKILENLLLALDYTGSIPKRFLLQTGAKHYGVHLGPTLTPMEESDPRYLGSPNFYFPQEDLLAAWCKKHGTSWNVTRPGFIIGAVPNAAMNEAYGLAVYASVQAEMGEGLEYPGTIAAWGLEKHLSAARLIAWHAEWAVLTAQAKNQALNISDDSMFTYGKFWPVLASWYGVSYGTPPEPVNSVQMPYTPPPRGFGEAGKVEFAWSFQEWALRDDVQNAWRRIAERHSLVKNPFDNVTDVFGILDGDISGPWARSISMGKSRELGWHGYVNSHAAIFQTISELAELKMVPPIPNKFDQVVKYVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BS82</accession>
    <name>A0A0D2BS82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234285.1">
        <property type="nucleotide sequence ID" value="XM_016381183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BS82"/>
    <dbReference type="STRING" id="91928.A0A0D2BS82"/>
    <dbReference type="GeneID" id="27333933"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06850"/>
    <dbReference type="HOGENOM" id="CLU_023194_25_2_1"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="2">
        <location>
            <begin position="137"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40395" checksum="B108B45D46A35C7C" modified="2015-04-29" version="1">MAPIRVGIVGLSSKPGAWATLAHLPRLASSPNYQIVALCNSSLESTKAAIKAHNLPPTTRAYDTYEALAADPDVDLYVVSTRADTHYDVAMPALKAGRNVFVEWPLAANTEQAKEMAALAREKKAKTIIGLQGRMAPSVKKVKELIDTGAIGEIHSVNYQGAIHVWQNNAASDRYRYFMDRKIGGNLLTIYGGHVLDSILYAVGELKPGSYTPMAVNLRPKMHVMKSDGSLSEELYDKNTPDQILVQGRLDRHPSAVFSFHLRAGDRFIGCPGSTWRIYGTKGELAVEFASAGPQMAKAISMRFSNAEKGVVEDIVVDEGGDEWTQLPSQGQNIGRLYEAYAEGQPYGDFDLAVKRHELIDEFWASLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSN4</accession>
    <name>A0A0D2BSN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phenazine biosynthesis protein PhzF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241651.1">
        <property type="nucleotide sequence ID" value="XM_016376375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSN4"/>
    <dbReference type="STRING" id="91928.A0A0D2BSN4"/>
    <dbReference type="GeneID" id="27329098"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02015"/>
    <dbReference type="HOGENOM" id="CLU_048756_1_0_1"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF32">
        <property type="entry name" value="ANTISENSE-ENHANCING SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35394" checksum="54E4B0599387AA89" modified="2015-04-29" version="1">MPATLSFVTLDVFTATRYTGNPLAIIRVPSSTTLSQSQKQRIAREFNLSESVFLHEQTESDKSNESVRIDIFTAQAEVPFAGHPTVGTANYLLRILPKDGPLRGIEALQAKAGRFGITLDDSVAGARISVAHNVHVHSSLGLEQRLLTGQPRYVAYSVISIVKGMNFILVQLADLDALKNQTGNLVGSESTYTAHTALDEGWRTGLLCTYFYVDLGHGPSSSPSDSDSGSEPTTRHLRTRMFGSREDPATGSAASALASYLSLQTGTAGRYKYHITQGVEMGQRGEISVEVSTTTAAAATEGVVEISEVLLGGSAVLNMQGTLEVPDSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSR2</accession>
    <name>A0A0D2BSR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241676.1">
        <property type="nucleotide sequence ID" value="XM_016376400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSR2"/>
    <dbReference type="GeneID" id="27329123"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02040"/>
    <dbReference type="HOGENOM" id="CLU_156006_0_0_1"/>
    <dbReference type="OrthoDB" id="4120191at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="108" mass="12674" checksum="7BD2AC17464E0882" modified="2015-04-29" version="1">MSEMNATTGANLDNEMQEISNLVTKIRKNLLNVKSTWGPESHQYRDALQAMQEFMREKDGLYERMDRMLAKSRELEKDVPSEPQKDIDVRQNITERTIEQFLADLKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSU2</accession>
    <name>A0A0D2BSU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241701.1">
        <property type="nucleotide sequence ID" value="XM_016376425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSU2"/>
    <dbReference type="GeneID" id="27329148"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02065"/>
    <dbReference type="HOGENOM" id="CLU_1224796_0_0_1"/>
    <dbReference type="OrthoDB" id="4159102at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="226" mass="24945" checksum="20B9836C120C1D79" modified="2015-04-29" version="1">MAEQPYDRLSFILWLIWYYPGTIVTTCVLCHVAARAAEDATARKIDHSAVQIRHEIPTEARKPGDASGSDSILLRAQDTDEGALKRLSRVDEQPYLGPGSATQQENHHGSRSKTSSVTLMKIAIFWQGVQILLLERMGRMAARERTLTGDPIFVSVVILALCTTLVLLSAARLQDRWNEARIGKTGAGADLGEEMKKSRPTSRLILAAVLLVSLPWYELLTATHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BT28</accession>
    <name>A0A0D2BT28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241771.1">
        <property type="nucleotide sequence ID" value="XM_016376495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BT28"/>
    <dbReference type="STRING" id="91928.A0A0D2BT28"/>
    <dbReference type="GeneID" id="27329218"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02135"/>
    <dbReference type="HOGENOM" id="CLU_071690_0_0_1"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="125"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="250" mass="27884" checksum="FBED0ABB724D2AEA" modified="2015-04-29" version="1">MPPSKRNRIVHTSKTHKNRKELVRRLAANVQEAAEQYNYIWVFGVENMRNNFLKQVRSDLSDSRIMMGKTKVMMVGLGQTAETECVPGVSALGPYVKGEMGLLFTNQEPSEIEQYFQGTLNLDYARSGTIATQEVRIPPGELHTMYGVPGGEEDPLPIQIEPTLRKLGIPTRILKGKVVLEERPDGAMVDDDEGYLVCREGDTLDSRQTNILKILGVRMSEFKIDLKAVFDKTEGAVREINGMDVDGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BV55</accession>
    <name>A0A0D2BV55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235340.1">
        <property type="nucleotide sequence ID" value="XM_016382238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BV55"/>
    <dbReference type="STRING" id="91928.A0A0D2BV55"/>
    <dbReference type="GeneID" id="27334994"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07911"/>
    <dbReference type="HOGENOM" id="CLU_007383_12_2_1"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="346" mass="36986" checksum="2F0B4454F5091756" modified="2015-04-29" version="1">MTPPQHQTTSSSPAHTVFLTGVTGFVGGTILATLSERHPDVRIKALVRQEADAKELQAVYPNFTPVMGTLSSLSLLASTAASADFVIHAAGDNVEAVGAMIEGLALSSGSATATQTPTPRLISLTGPRSLIDLSIPITGVARSDSKIWSDIADAHAILDLPSHRMHAGTDQAIVKHSLARGVGTILVSPGQLWGQGKAHLKKESNSAMYYATAKSRGRAFVIGDGSIEWSWVSIGDLGAAVVFLLEQAILNGPEARQRLGINKEGYYFVQTGDVSLRKRADAVSQRLRLGEVESISIDTAAKIHPFGPIMWGCGERTRADKLAELGWKPKELDWRVLMEEYGGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWY2</accession>
    <name>A0A0D2BWY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_05864</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236030.1">
        <property type="nucleotide sequence ID" value="XM_016380203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWY2"/>
    <dbReference type="STRING" id="91928.A0A0D2BWY2"/>
    <dbReference type="GeneID" id="27332947"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05864"/>
    <dbReference type="HOGENOM" id="CLU_020019_1_7_1"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="270"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW15814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="34777" checksum="8214BBCFDD69FD42" modified="2015-04-29" version="1">MHLKRIRPGHTGTFMGFLPDAHRNHMTAFISELAGTFLFLFFSFAIAQVANTPPPTGEAARPNLLTIFFIALGFGCSVAINVWLFYRVSGGMFNPAVAFTLVLIGAVPKSRGAVVFVAQILGGIAAAGAVSATLPGPMAVNVRLGGGCSITRGLFIEMFTTIQLVFAVVMLAAVKSKATFLAPLGIGIALFIGHMLSIYYTGAGINPARAFGPDVVTHSFPGYHWIYWLGPFLGSLVAAGFFYLLEAFDWTTANPGQDFDDLEVQMMTPSKKTSRPNIALAPSRSAAGNDFNSMSMSSDKHTLTDGAVTHDSHPLPVSPGAKEEQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXV1</accession>
    <name>A0A0D2BXV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_06155</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236320.1">
        <property type="nucleotide sequence ID" value="XM_016380493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BXV1"/>
    <dbReference type="STRING" id="91928.A0A0D2BXV1"/>
    <dbReference type="GeneID" id="27333238"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06155"/>
    <dbReference type="HOGENOM" id="CLU_001805_0_0_1"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="16">
        <location>
            <begin position="280"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW16104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="793" mass="88523" checksum="3121A23E6301A040" modified="2015-04-29" version="1">MHKVLRRQPWTCPKCLRRQKRLNSTATGTASQQNDAFASAYVQSSPARQTDNAQLREVFNDRVSWRTSEKKSSGLIGNNHLTTPRGFKTFAERSVAQCKRLVERTLAASTVEQYRAIPKDLDRLSDLLCRVIDLSDFIRGIHPDAAVAAAATASYSLMFQYMNELNTTTGLNKQLQKAWDMPEVRSQWTEEERMVAKLLMKDFAKSGIDLPEKQRKQFVSLSNEIAQIGTDFVNQMEHARDQITLSTQQLQGVDPLLIRNLKAWDRAQIPVYSAASKTILNSANDPETRKQIYVAERTASRSTVRKLEQLLLRRAELAKLTGYDSYAQMTLADKMSKTPESVSNFLDSLNENNRPQVQKELASLLEIKRKLDQGAKSVDPWDHTYLLAKLAQVEASAGPRTSRSRLQESASAYFSLGHVMQGLSNLFESLYGVRLVPKETQPGEVWHPEVKRLDVYTDKQQHIATMYCDLFSRPGKLPNPAHFTLLCSREISEEEVRECQERNEPLNNGMPTYLGSNAVSGVTAHHQIPIIALVCGFPDPSSSAGPSLLSVHSVTTLFHEMGHAIHSILGRTTLQGISGTRCATDFAELPSVLMEYFATDATVLKMFARHWQTGAVIPDDMITALADDRTKQAATTGAWNNESQILMAILDQVYHSEGPVEALQIGHYNSTAAYHDVWNKYGSVAEPRETAWQGFFGHLYGYGASYYSYLFDRAIARQVWRAVFKDGADGGAVDRSAGEHFKQEVLRWGGGRDPWLCLEGLMGEGRGVLAEGKEEAMLEVGRWGVGASSEGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZ74</accession>
    <name>A0A0D2BZ74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236820.1">
        <property type="nucleotide sequence ID" value="XM_016378143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZ74"/>
    <dbReference type="STRING" id="91928.A0A0D2BZ74"/>
    <dbReference type="GeneID" id="27330875"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03792"/>
    <dbReference type="HOGENOM" id="CLU_009834_3_1_1"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31175" checksum="33EE85C48547108D" modified="2015-04-29" version="1">MPPVPPLFVLPIPPSSATSATQQQGSFICTQAAPQVYLLSFSSPPDNRLVPAFNETFLLALDIIEHKLPRGVVVTTSSIQKFYSNGLDFENAIRDPNFFPGSLYPLWRRLITYPMPTIALMNGHAFAGGLMTAMMHDYRIMNPHKGFVCLNELDFGASLQPTMASVFRVKLSMSTFRNMVLESKRYPALEALKEGIIDGVGSVDETLAFIAEMKLTQKAQGKSYGKIKEELYREVVKDLDEGSEVPKTLAARDLDRNRRDLEARKRVDAYQAVVQRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0B9</accession>
    <name>A0A0D2C0B9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237240.1">
        <property type="nucleotide sequence ID" value="XM_016378563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0B9"/>
    <dbReference type="STRING" id="91928.A0A0D2C0B9"/>
    <dbReference type="GeneID" id="27331298"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04215"/>
    <dbReference type="HOGENOM" id="CLU_760840_0_0_1"/>
    <dbReference type="OrthoDB" id="5335351at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="364" mass="40712" checksum="657038ECF6924358" modified="2015-04-29" version="1">MALVCKWTSAQGRPECRRIAGDGESMESRKDHFRVVPPSTFSLWVIEIYIKEQQKRMMELSTNEPERSVPASPPQGGEQTEMDAVTAVNSSPLPTRSRHAQTPSITKKRTNDEVYEPVQSPIRSPTALKASARHNKAESTVSFEDGNGVRKPNRHGIADDLRDSEGLGSKTQTIPGPEAERGHGESQASPNHASEQGLARRIERYQQELQVEFDQFQQSLAERDRTAELELLDWEELESRYQSEIQPKMAAEQEIMDEFQARFQASETCIPDAPKTSLTNRALAIHAVHASMQRLRGGTSCEEIKNANCNCWECRVLLGQEAGSLSSTLSRVQWNYWGMFEGLNPTGADRVMGDDALGARVDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0I3</accession>
    <name>A0A0D2C0I3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237365.1">
        <property type="nucleotide sequence ID" value="XM_016378688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0I3"/>
    <dbReference type="STRING" id="91928.A0A0D2C0I3"/>
    <dbReference type="GeneID" id="27331423"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04340"/>
    <dbReference type="HOGENOM" id="CLU_033913_0_0_1"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239369" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="123"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="444" mass="51047" checksum="93335FBB34388C16" modified="2015-04-29" version="1">MSGNSALFVLAQALFISRCFSECVAVLERSMSRRRGSHWGHESSRYVKHLELKQYAERALRHEERYLEKDDSWRDSTEEEQHAMLGKGDIRVVPYPWIPKTLFRRSESAISRANKTLQDYSQDSLVIRTSSLSVPLRSSGQIQHGQDAYGIFAMRDLPANTKLFLDKTILCASNGSAQCTACCADLSRGASRFQGKRYCDRNCFRDLQAACGVGALSRHGQGRQATRFRMNGFQPLLPDSGFKSVVNEEHLLFQRAVEVAFHSTKRHPGQHPLQARMLRLLTARYHHGNQATRRYSYAEDVCRRIEFLQQLGVDIFQDELGEAWVLETLANRIQTNFRGYRGKHGDEVVAVNTMYAFFNHSCVPNVTTSHSRKENSAICMTTTRRIARGEELYINYLSDEDLDESHDVREEKLQDWTGGMCLCVKCTRERNRRRWSLRFHDDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0K5</accession>
    <name>A0A0D2C0K5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GTP-binding protein ypt2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_04380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237405.1">
        <property type="nucleotide sequence ID" value="XM_016378728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0K5"/>
    <dbReference type="STRING" id="91928.A0A0D2C0K5"/>
    <dbReference type="GeneID" id="27331463"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04380"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW17189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="210" mass="22894" checksum="EC6003F6F74C8771" modified="2015-04-29" version="1">MAGTRNYDFLIKLLLIGDSGVGKSCCLLRFSEDSFTPSFITTIGIDFKIRTIDLDGKRVKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDEKSFNNIRTWFSNVEQHASEGVNKILIGNKCDWEEKRAVTTEQGQALADELGIPFLEVSAKSNINIEKAFYSLASDIKKRLIDSSKETGSGGGAQSGPGGVNVAQNQSGGVGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C2K9</accession>
    <name>A0A0D2C2K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238085.1">
        <property type="nucleotide sequence ID" value="XM_016379408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C2K9"/>
    <dbReference type="STRING" id="91928.A0A0D2C2K9"/>
    <dbReference type="GeneID" id="27332147"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05064"/>
    <dbReference type="HOGENOM" id="CLU_104738_0_1_1"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000114">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="12"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18790" checksum="E71F7A7BE4832ECD" modified="2015-04-29" version="1">MSTAFANFQQKMNSLRIEADENAAKAEELKAKVKELEQDNLQKEQEITSLTHRNGLLEAEVEKLETAIKDAKAAAGQASEHSNLNEALQRKVQVLEEEAEVADKTLRETSEKLRQTDVKAGHFERKVQALEQARDEWEAKYEEMAKKHADLQKELQELEQSMGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C7D5</accession>
    <name>A0A0D2C7D5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00036</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239680.1">
        <property type="nucleotide sequence ID" value="XM_016374404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C7D5"/>
    <dbReference type="STRING" id="91928.A0A0D2C7D5"/>
    <dbReference type="GeneID" id="27327119"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00036"/>
    <dbReference type="HOGENOM" id="CLU_003318_1_0_1"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
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            <begin position="1036"/>
            <end position="1092"/>
        </location>
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            <begin position="65"/>
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        </location>
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        </location>
    </feature>
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            <begin position="106"/>
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        </location>
    </feature>
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            <begin position="126"/>
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        </location>
    </feature>
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            <begin position="157"/>
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        </location>
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        </location>
    </feature>
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            <begin position="308"/>
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        </location>
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        <location>
            <begin position="323"/>
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        </location>
    </feature>
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        <location>
            <begin position="342"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="436"/>
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        </location>
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        <location>
            <begin position="512"/>
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        </location>
    </feature>
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        <location>
            <begin position="610"/>
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        <location>
            <begin position="715"/>
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        </location>
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        <location>
            <begin position="742"/>
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        </location>
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        <location>
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        <location>
            <begin position="904"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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        <location>
            <begin position="1010"/>
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        <location>
            <begin position="1039"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1144" mass="126668" checksum="FA5C2EA33A0B206F" modified="2015-04-29" version="1">MASKTTTIGSSAWVSAEKENALQLLQTEKEELVFPAQHQLEWLNEHVSEIFKGRQVDVVNVFKTPGKLKGKTPHTTRKRNVPDARIPLSDVFSSKPIPRPSPPKNPSHDRPHFEIATDPAQAAAGRSQTDSGYHGSSQENTELDTKRHTPPLVGEYDVEHLEGPDRLMEVQPEDASNAEHRTTEGSFHSAKEDQTVKMTAPVAAKPGDSLKDPGMQVDGSGLEMPHQQQQADTDHDFDELGSPSDESTPDRPLVRKSSLTFAALPAREPMKTSIGARVSRTSHVDTTRQIQPNASRPLAPSHRTQHGNPDHHINDVEMRDADDHDENFEVLGQDDSEEDTQTAKNYSKSSTQRLHEKIDMLGKAPAPRPSKSIPSASSLAAMRQHDAVVPEEEPTTDDRRPNDDDDDDDWIKPLTSPDAAGSSAAISRRNDHVYGSDEEEDEDDDDDDGEEEEFYMRAPELVAHEERMKTPVRASPGPGRIMPGYGHTKSASTATLASPAKAAMAPPVSPAKSISVSNPARATTTPLGSPKRYLDLSASKSKLQSIMKTAKGLFTTSASISAAAKLETLSPDALKVAANAMPGMYPNLNGLVEEKPLPPSPAKQGRRTRSSMEREKEERRKDKETQMKQRMDDQLEQAREQERRKVAEQKVQQQTLHPTRHEQPNCPSPKRHFDEHAFQEPGEPQPTGGRPARPIRPGREPPKTKPAPVSIRVGTLSQRMPNGSSQVPQDSLTAEPKRPGLTKKASTASLQSSTSTTLKSSIHGQPPKPRALLAAERKKEQDEREAQRKLEQKREIERKRAAQQEEARKQEQKQRAEAEKRERERVMAEQAKRQAQQQAIERKRQEAARKAEQQRLERAANEAAQSRPPSRLAGQNPTRSLINHPLPTNPAKPAKRPLEEEASRPQTSKYGPSGLTQGDSKRRKTEEEDAIEPMSRPVVSGAPIRQSQLGKKPSIFNHSAYTQAQPSGHLNQFPQPPSRAAPPQMQQYATGGRIPFADAAPPAPAKTPISMMQQKTIQTVKSSPQYPNGEAIHLPEIPTDSEDEDSEDEGNAFPIPDWATPGHLTEQLMRQEGMDGDAVFGPIAPLKMEEIFAKGNKDRLKRLRDRTSSANWTLSGDGLTLEEVRADREQRERMRLEGGWKFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CDK5</accession>
    <name>A0A0D2CDK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016376554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CDK5"/>
    <dbReference type="STRING" id="91928.A0A0D2CDK5"/>
    <dbReference type="GeneID" id="27329277"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02194"/>
    <dbReference type="HOGENOM" id="CLU_005767_2_1_1"/>
    <dbReference type="OrthoDB" id="6486656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF17">
        <property type="entry name" value="SCFA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="285"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
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        </location>
    </feature>
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        <location>
            <begin position="484"/>
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        </location>
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        <location>
            <begin position="634"/>
            <end position="689"/>
        </location>
    </feature>
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        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
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        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
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        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="733" mass="81471" checksum="D7F16AA888AE2057" modified="2015-04-29" version="1">MHVSDAGGRSCAATTPVPVLYAFESESRVRNVLQDRGDLSSLANSVAAFTYWDHRGLRNASPARSLQDDRPSAPETPLLNSSPLSGTGQDSRSQQSTVDTPHLYRPRTSTYEVVDKIFKEHNPQGTIHHTSAAIPGGSPEARTHNSEVQYLLVSDVVGEDLPPSEIIDLALDAYTRAVHWFMLMLHLPTFRAEMQTFQGTGYVRADRVPSLVLVILVIAVGAKYITSQTAREKCPGFDLNGLGDRFIGKVEEKLLDVYEASCIEAVQISAILSSFYLYQGRPSRSVAVNGSCLRVAMTLGLHKESSWKMQDVVTRELWRRLSWVIYTAEVFGALAYGTPGTIRDDEWDVSLPENIGDTPETCPGFASTETYEGEPCGPVTILSYQRYKFRLYRIASSITRTIYRPNGASWNSIATEIKAINDRLQQWEKSIPPELRLSSLRVTADNEYDRRMIKIFQLQALVLQLSYDNIQLVLHRPLLTMNRAPSPPALNDTGQSQGPFGDGSSRNLSDLNEMIKTSRYQCWVSAMRTSKMGDHAEILSASRETHGGAYVGIQSFTAGVVLGIFALSDPLSDQAHQAKRAVSKIIKLPRLYEYRTTISDQCGVILEELLRLILAEEMKALLVEGDASTKAGAAEQAIARSRANSNSAESEQPGHQRFPRIDFDPPLTNTDDFPSMDNPRSLPDQSPEIPRDICMGNFSDALLSLQDIRTSNTFDNTTQAWIWDDLIWQPEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7F1</accession>
    <name>A0A0D1Y7F1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231052.1">
        <property type="nucleotide sequence ID" value="XM_016384450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7F1"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7F1"/>
    <dbReference type="GeneID" id="27337218"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10135"/>
    <dbReference type="HOGENOM" id="CLU_521785_0_0_1"/>
    <dbReference type="OrthoDB" id="3944408at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="528" mass="57501" checksum="11E7FAC896DD69FD" modified="2015-04-29" version="1">MASVRRTKNFALDGQTPMFLYSILKQLDLRSIDWNLVAESLDISNGHAARMRYSRMRTQFEAMSKDAKPPKPKKDNEAKAAKEKAAKSKRALLEEETERLGTGKQAVRASGQENIHKRPKLGQYGSNPWVSTVMPGQQYTNSFWPHPNSSIKDEPTNGNSSSTTTTPLIKKDPELSETSTTTNINMSTSTGTRIKQEKTVKEEPKTNDVLQESPPVPSIEDKNEVAAIAMKQDPSYSPTAYYYPSYRYGTVPGTYQPQNAAGYYQTFPMPPGPSTYPMQQTYAYNPWIAPRQSINPWSHSAMGPIAASAAPTAVNENVMDHVSLNPHASSYEDLLNMPLYSGTPQNFQFDVATPEPPVEAQTVAGNMVDAPAQNAVAVTVEPPSASFVGLQAEKEKFSSPPVRAASKDAAPEKPAQHNVVEANAFAEQSKNSTELALVSGVGSDVRISAYPVVAGDRTSTDNEVDAEHEIDDEQTTHVATITTATTTTLVAEADKESKVVMKPVVAVAIDVEEPKVVIKSEPVEILDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7M2</accession>
    <name>A0A0D1Y7M2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_10215</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231132.1">
        <property type="nucleotide sequence ID" value="XM_016384530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7M2"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7M2"/>
    <dbReference type="GeneID" id="27337298"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10215"/>
    <dbReference type="HOGENOM" id="CLU_021259_5_1_1"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="117"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="426"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW10916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="508" mass="56036" checksum="337AE15995AE55B7" modified="2015-04-29" version="1">MNGVDYKRFVRYFYDPPPKYDDMSGTSIWLLGKEYKPTPPKPVTTTDHDDVVEVESSTESHDPSETSGSSVTADISYQPQQPHHISQSTSTLDDVQHVTNANLPSLSNDPADGGWPHAFLDDFESRIWMTYRSNFTPIPRSQEPSSNSGLSFSVRLRNLTEREGFTSDTGWGCMIRSGQSLLANALLTLQLGRDWRRSTCASSEEASIVSLFADSPSAPFSIHRFVQHGASSCGTHPGQWFGPSATASCIRELSGECAAAGLRVYVTPSASEVYEDRFRSIAAASSTDSTIKPTLILLGIRLGLDRITPVYHEALKSALTYPQSIGIAGGRPSSSHYFIGCQGDMFLYLDPHETRPALAYHDNAAEYTDEEIATCHTRRLRGLRISEMDPSMLIGFLIKDEADWVDWKRRLKEVKGKAIVSIFDKEPPVPGETKERKEAVDEVETFDDEEDEEGDGDDDGTVTVTGKDIEPEPHDVRAGAVQDAEDDGVRVDLHAARNDDVPLQAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y9E5</accession>
    <name>A0A0D1Y9E5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231827.1">
        <property type="nucleotide sequence ID" value="XM_016385225.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1Y9E5"/>
    <dbReference type="GeneID" id="27337996"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10913"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_7_1"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="6">
        <location>
            <begin position="96"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="7">
        <location>
            <begin position="310"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="5">
        <location>
            <begin position="598"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="859"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="892"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="924"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="957"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1100"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1135"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1169"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1237"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1271"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="637"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1374" mass="154293" checksum="0304DBFBE49D4A45" modified="2015-04-29" version="1">MSLPTSGSTGGTGATGAAVPPQTKDQSTVSSKDPWEEAFDTLDIETQSQFKKDDTNLLGILRQIQTSTEENKALCLEKGWKAYRNKKGEDVKLRHVLEKISAWVTEIISIVEVPVSFDPSSHAALPWAVIKFLVTVGTNDVAVFSNMSESIESVSRLIARYTIFEKLYLREADCESGPQLHEALRELYAAILRYLANSKRYFSGNSISASYQDIKINPRILTIFSRKIRSKPSKYLEVQRKMAKDSVASYETLRAMLHKLDRPIMQLADSLSVIQDRFKSEERKEVFLWMSEIEYREHHQDLSKDVLPNSGQWLLKGREYIEWGQSSVSSILWLHGIPGSGKTKLVSTVINDVFEAHSNMIAPPIAFFYCVRNDAERERALPVEILRAILRQLSSTQPDQPIKEPVATEYESRKKKGDEDCSKIRKLTVEDCTRLILALTNHSPATIIIDALDECDEFLRHELLEALDEIVSKSSQVVKVFVSSRDDVDIELRLRQSKNISISADKNGQDIERFIESEIDKLIARKLLLDGKVSPRLRGKMTKVLNKGAQGMFQWVALSLDVLRRIKFKPDFEKALGQLPESLSALYDTIHARIEKTETNGRRVAVATLSWLLCAQRLLSTRELVAAVSLDVEVDDETPPVSYNTDLDPDDELSDAESEGEPGSVSITDIIRLCHNLVIVDSELDVFRFSHQSVREYLQYRNDYIAAELHALAVERCLHVYLVGGVMSRSPAISTVVSWGDLLKSYARLYWPAHYQAAEEIMSAMLKERILPFFVEEKRTSLAYTTWAREINSEYADRSDIFRALDSKRRDRLGHRIWSAALRPPSPFRAACAFGLFSLLEELDKVSQDSLNQLALSGDKLHLLHIAAKEGHGQIVERLLGEGFDPDTRNEYDETPLLSAAKEGREVITKVLVNNGSNLEASDEVGTPLIWAVVRGDEAAVKILLEKGANFEASGAFDMTPLMSAAQQGNEAIVKMLLEKGANLEALGANGRTPLTYAAELGNDTAVRMRLVNGADLESPAEVQGWPALLLVPHPVDVGLEWRGHKEVVMMLLRKGVIRDSKNEDYDDIQLSVAARFGDEAAVRALADKGADLEFVDDIHGLAPLSWAIRGGFEAIVEFLVEKGVDVESRDHGVYGGTQLIWAIMTGNTAAAKLLLEKGADVESRDWRYGWSPLTWAVVDRRRSLVELLLEKGADIESKDQFKGRTPLSWAAERGEAATMKLLLEKGADTESTDQEDGLTPLLWAARARREELFRLLLDQGARLEERKYKGGRTLLWQAVENGWEDIVQILLEMGFDADSKYNFWGLSLREWAAKSRQQLTDSMWALINAGVDVETEDSEEKRNEEPSLKAPEMGHECYVSLHPGYKFLNKWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YAU1</accession>
    <name>A0A0D1YAU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232222.1">
        <property type="nucleotide sequence ID" value="XM_016383599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YAU1"/>
    <dbReference type="STRING" id="91928.A0A0D1YAU1"/>
    <dbReference type="GeneID" id="27336363"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09280"/>
    <dbReference type="HOGENOM" id="CLU_008578_2_1_1"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="314"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="713" mass="78073" checksum="FF5F0F43FD455BCD" modified="2015-04-29" version="1">MVFADGGRRSPERRGRSSSTISGPVSGMVHRPRLESDVRNASAQRARADAALNITNLSDEKPVASGNGVSVAIALAEPVLFLQGYDANDPSTHNTTMLRGSLVLKVSKQAKLKSISLNFRGKSETEWPEGIPPKRTEFRDTTTIMNHTWSFFNAQIPSAEYSYGADLVQLSKGPSVESKELGVTSSFDLFQRSASPAKAASTAREIKRLSLQANQSRSFGKGDTINGGPTVAQKGFKVFHPGDYIYNFELPLDSRLPESINVDLGNVKYELEALVERSGAFRANLVGAKELTLIRAPAEGSLEQVEPIAISRNWEDQLHYDIVISGKSFPLGSTVPIAFKLTPLAKVQCHRIKVFVTENIQYFTNNKKVHRLEPTRKVLLFEKRADGHSVSSYPGSSMRILAGGGVPYDYRSAAARGEEDIPRDQTNLLGNLDNDAGSIGPTEMEFNVQLPSCHQMKDKLRSERLHFDTTYSNIQVNHWIKIVMRLSRPDENDSAKRRHFEISIDSPFNILSCRATQANISLPAYEAGGTAPTPADEFECGCPGAALRRRNTPPTSQNRVPPINTQVGSGPGPGVQRSWTNDSGGLTMPSQAHVANDPNNTQPRPMHLLRAPSFNPPPFDEDEPPPPLVTPPPLYDNIVPGDSSAALADYFARLADETSDEDDRLDRSRVDYPLTPGGRLNRSMDIPRTWPPLGSSSNDPRPSNLVTSTSVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YHQ9</accession>
    <name>A0A0D1YHQ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_07240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234672.1">
        <property type="nucleotide sequence ID" value="XM_016381570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YHQ9"/>
    <dbReference type="STRING" id="91928.A0A0D1YHQ9"/>
    <dbReference type="GeneID" id="27334323"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07240"/>
    <dbReference type="HOGENOM" id="CLU_010194_5_1_1"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW14456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="41888" checksum="E9B4F96FD9F9176C" modified="2015-04-29" version="1">MVSSASAAPHSRSSQPKPWHRVITLDLILLILANSVFHPYITFIFYLCIAALHKHREPIAYYTLWYTGFLAVVEVAVWTNQRITYGKHRIVAWENEVVVITGGANGLGRVLAEILLRKGVSVAVLDVREPDEEARETMERWDLLWEVVDVSDAKKVDEAIEKVVKELGPPTILVNNAASTVTGLPILPLLPSSALTSSHPNGPSSTLSPTQASKTLSVNTISHFNLLSAVLPHLISSKTGAHVVSISSVLAHLSPASLADYSASKAAVATLHKTLCHELRAHPDPSVFAKVKTLLVEPGQLDTQLFAGITSVPFYAHFFGPVLTAQEVAKEIIRTIERGDGGVIRMPFYAKCMPLFDMLPGTLQLCVRWFSGVDAAITQRNKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJD6</accession>
    <name>A0A0D1YJD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar import and degradation protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_07843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235272.1">
        <property type="nucleotide sequence ID" value="XM_016382170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJD6"/>
    <dbReference type="STRING" id="91928.A0A0D1YJD6"/>
    <dbReference type="GeneID" id="27334926"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07843"/>
    <dbReference type="HOGENOM" id="CLU_007002_0_0_1"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="32"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="263"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="444"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="93077" checksum="88FDFB994AA9D443" modified="2015-04-29" version="1">MFMIKNGMIFRSRSIILKSRTPLLTRNPQNIVSKYLFGDVSKEVITEIPQGQLYLVRPLSPKGYSELIYKDAVASIRRTGQEFQYQLVIQRAYEEGEEELAEDDEDEGVDALDKDEKTFLLDQDLHFRSEQRSGGETVLAWRDLSGDPGDLYEFVCDTSIQQEKIQTFLLAAIDCQYERKHRRSAQRATDAELREFYFDNEDAIPAASSVSPAKDDIPTSKESAQRMAKDVTSPRKANESKTTGVVSATTEAPSAKTAPASGEVLTKQKAELHLFDFQTSTFILQDASVFAVVTDLGKWQYWLQITSSDGREWLGQQIVADINPVFNFEYLSAIFNHYTDDGSAYSWLLRFQDQATLENFQEGIMQALWEQLNEMKWAKVNEPEREYVFEAFNELTMDDVPEEAEEDEEDEEDEGEDDGAQRSEHYDTDESEDDLDLRDSDGNVNSQLAVGTKHDRSFVIRGSKIGVFKHLPNRHLEFTTNISKVETPKGKLFRPNKVMLHAEDQNMVLQDESNPNALYRMDLEYGKIIDEWKVHDDIPVTNFVPETKFSQQTSAQPFIGHSRNALFRIDPRVAGNKLVEAQLKQYVSKNDFSAAATTEKGHVAVASNKGDVRLFDRLGVNAKTHIPALGESIIGLDVSADGRWLLATCRTYLLLIDTLQKDGKYEGKLGFERSFAKDSKPQPRRLALTPSHVAQFQHETGAPLSFTPAKFNASPENPETSIITSTGPFLVTWNLKKVIAGNKDPYQIKRYGDKVMADNFEFGSDKNVILALPNEVDMVSRKSFKKPTRESIAGPAARLSAGGLATPRRSGRQSHLRDEIVNSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJF8</accession>
    <name>A0A0D1YJF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235312.1">
        <property type="nucleotide sequence ID" value="XM_016382210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJF8"/>
    <dbReference type="STRING" id="91928.A0A0D1YJF8"/>
    <dbReference type="GeneID" id="27334966"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07883"/>
    <dbReference type="HOGENOM" id="CLU_009705_0_0_1"/>
    <dbReference type="OrthoDB" id="4158477at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052109">
        <property type="entry name" value="SRRM_Domain-Containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237016" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1117" mass="111812" checksum="3962B7337B727C5E" modified="2015-04-29" version="1">MKWTKSATNKVALTLLAADMAMADLPTVVEPCPEATSLSIPPVTVTAQYQPISTCAPTTVCVKGTCATKYPLTAFPFVSTVVPFAWNGTTSQLTTVTDIAQPVRASEFLTTLTQVTAAPSLDKRSWVDWFKEKSHAPQSTTLYQTVTRRAMVPYKEIGPLCIPEWEGSGLCEKCEGKSDGSRSQLLDVTECRSGVNVDGKAYEKCVEWYETIIERPAPTSTVTARALCSSEGKIPHAGVYTWTFPQVAPPVTITAPPTTVTVTVKGRPSLHVIPKEVKVIPGKAWNAYVTKSFSGPTTFQFNVYITKVIIFNVPWFTQPAGNTRHIPVPTGGHGGKGRNWWPLPEPSKGGSAGQAWEDWNSVSSTTTSVTSTGGPISQTTSSSSSSSSSSSTSTTSNGSGPTGASTSSSSSSSAASSSSSSSSSAASSSSSSSSSAASSSSSSSSSAASSSSSTSSSSSSAAASSSSSSSSSSSAAAGSSSSSSSSSTSASSTTTPVPTGTGFVLQVSASPVANVKRQETVTRYLAFDSNQVGFAVEARVSAAIVFQGTEGSFISEGQFLGTTRLDTSFIRRLATVPLGFRFWSVVFGFARLDGTTGFCLSDNGRIFAYVAPDTCSSPIVLIPTPIDTASSTSSSASSTQTSSLTSTASSTTGVETTSTSTSSTTEAETTSTSASAASSTTEAETTSTSASAASTTTGAETTSAASSSAASTSESSSTTDSETTSTSTTGAETTSAASSSAASTTASTTEASSTTDAETTSTSTTGAETTSVASTSGAVSSSSTSAAESSSTQGSTTTFTSTASTTSSAPATTSTSGAPICNINANICLDSDLIQANIVATENCPLLGGLTCTLNDLLSLVPALLGSSPNVLTVIAADNQVLGLDISPEQVQAALVSGTLNQVCSALGTVSVTITDPTCPAPPASSSTSSTAAASSSTSAGGNGASSTSAGASSTSAGASSTSASASTSSAGAATTSAATTTANGGATSSASSTSATPTPTCGLQVSLCAGQTLEDVGLNEVTCDTGISGVLCSVTQVLEAALNDCVGDCAVYGQTGTLGVDLNPIIGLQSIQSIQAAVANYPNCQPGGPTVTLSEPTCPVTLLKRNARKARYMRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKI6</accession>
    <name>A0A0D1YKI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05532</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235702.1">
        <property type="nucleotide sequence ID" value="XM_016379875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKI6"/>
    <dbReference type="STRING" id="91928.A0A0D1YKI6"/>
    <dbReference type="GeneID" id="27332615"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05532"/>
    <dbReference type="HOGENOM" id="CLU_087110_0_0_1"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW15486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="189" mass="21340" checksum="0CF31A2D8AB9F5EB" modified="2015-04-29" version="1">MAASQKAARVGEETRVDKVNAELVTLTYGTIVAQLCNDYDHDYAQVNQQLDKMGYNIGMRLIEDFLAKSNTGRCSNFRDTADMISKVGFKIFLNITPTVTNWSADNKQFSLLFDENPLADFVELPDDGRAQDELWFSNILCGVLRGALEMVQMSIEAHFVSDVLRGNDVTEIRVTLIRYIEDEMPPDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKM3</accession>
    <name>A0A0D1YKM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235727.1">
        <property type="nucleotide sequence ID" value="XM_016379900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKM3"/>
    <dbReference type="GeneID" id="27332640"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05557"/>
    <dbReference type="HOGENOM" id="CLU_075341_0_0_1"/>
    <dbReference type="OrthoDB" id="4155399at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="263" mass="30080" checksum="FE3537CA542746CF" modified="2015-04-29" version="1">MSSSGNDFFSNVRSKWRQSRSSFRLSATSSTTNLTTSRPDLELWEGIPVEYHPVERAASRPPSGHYGTYRPLPGPPPRPRTTSPASKFRPILRIDTGNEPYIKRKEYRRRSDQYFSAAVQEQNSQLHYHDQQVQDRRRSLSVEIAAALPPEHLDPPPPYSPHLGPSRQYSHNQIRPHSYHADQEFPVLRPYDPQDYVSTTSLSHSTHHPSDVRRASMEIPTIEAQEPTPVSPMNSLDQQYLELRSRGPSVTIDSLLAHPMLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPU5</accession>
    <name>A0A0D1YPU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237462.1">
        <property type="nucleotide sequence ID" value="XM_016378785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPU5"/>
    <dbReference type="GeneID" id="27331520"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04437"/>
    <dbReference type="HOGENOM" id="CLU_001265_2_2_1"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="64171" checksum="6893A92ACF97C33C" modified="2015-04-29" version="1">MAEKSIYISEMAKTKESEAVGTGAVLPLDVDGDQNSDKNAWLGSTQQHPFSLPENARYWQNVYETAKYEGRHRFDPAYQWSASEEKQLVRKLNWRIMAWVWIMFASLDLVRRNINRAISDNMLAELNMNTNDFNSGQTIYLASFLAAELPGGLLSKKIGPDVMTPISICIWGVICACQAAIKNRTGFFITRALLGFSQGGFIPEMVLYLSYFYKSNELPIRLSIFWTAIPLTQIIGSLLAAGLLKMRGVNDWSGWQWLLLIEGLMSVLVGLATFFLMPASVTETHKIFRGRAAWLHSKTGWFTEREEKIGVNRILRDDPSKGDMNNRQHVDLKGIWHAVRDYDLWPTYILGVMAFIPFQPAANYLSLTLRNLGYSVFEANMLAIPGYFLFFVNILVVVWMSERYRERLIFSSLSNWWVLPFLIGLLAIPATASPWVRYALLTGVNGEPYAHAILVGMISRNSNSVGTRAVSAAVYNICYQIGSIVAVNIYRNDDKPYYYRGNKILVGITSANIVLFYLAKWYYIRRNQQKDRQWKALSDFEQANYLSTTKDTGTKRLNVRFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YR20</accession>
    <name>A0A0D1YR20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Opsin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04886</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237907.1">
        <property type="nucleotide sequence ID" value="XM_016379230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YR20"/>
    <dbReference type="STRING" id="91928.A0A0D1YR20"/>
    <dbReference type="GeneID" id="27331969"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04886"/>
    <dbReference type="HOGENOM" id="CLU_054785_0_0_1"/>
    <dbReference type="OrthoDB" id="10261467at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15028">
        <property type="entry name" value="7tm_Opsin-1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00327">
        <property type="entry name" value="BACTERIAL_OPSIN_RET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32767" checksum="F21BBA9F85E367E6" modified="2015-04-29" version="1">MLVHPDMLTALTPTSSVAPLPTVIPNPVITVEAGDVGRRTLWVVVVLMGLSSLAFYGMAFRVPVQKRLFHILTSFITTFAFLSYFAMATGDGVSYNTYTETIHHKKVPNTYQPYQREIYYARYIDWAITTPLLLLDLSLLAGLSGANILVAVVADVIMVLTGLFASFGSKSSQTWGWYAWACIAYLVVVYQLAFNGRTAVANKDSKTKAFYASIAGFTLILWTIYPIVWALSEGSHVINVNQEIIAYAVLDVLAKPVFGFWLLFTHDGMASTSPSLEGFWSQGFGSQGTLRVGDDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YU06</accession>
    <name>A0A0D1YU06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238962.1">
        <property type="nucleotide sequence ID" value="XM_016377392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YU06"/>
    <dbReference type="STRING" id="91928.A0A0D1YU06"/>
    <dbReference type="ESTHER" id="9euro-a0a0d1yu06">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="27330118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03035"/>
    <dbReference type="HOGENOM" id="CLU_006586_14_1_1"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF5">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="61"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="676" mass="75352" checksum="C595A6B7F00880E2" modified="2015-04-29" version="1">MGNLPELELVGLVQESKSKYINSPIDIQQQSTRPMASVTPVASKRLPYNGPTYVHAHPQLGNLTGRSISSSHFGRSSTPSTTVQFRSIPYATIPKRFAACRTLTEIPSDFDGRPHRDFTQFGAANPQLAGMRSTWFDSYGGPLQDDFDIDFDEFTCLTTTISVPQQHLIDLVEGNTQVRLPVMVYIHGGGAQEGVGAVDGLHSNAPLATYASSISMPVITVNIGYRLGWFGSMVCRDVLEEYSSDPNPSPHGPFNHCIQDQRAAFSWIHQFIGGFGGDESNVTAFGESAGGIFLVYHIAGSNEKLFNRAIIQSGTVLGHAPFELKELEYQGLLKTFNVTGSTPQERLEQIRQIPADQLIKYPGAHIFPFVDDIPDLHVRQPLFARGPVTYTSQTALIQSCEWLEELVIGDDFWEGHLMTDYVRSATAPAFVAVLLSTFPEPQAAKLLEAYDMPSTVDAAETADQNLFLRNLTLLVGDMMFSGMIQRLTTTLARDKSRKVYRYAFGLSNPFVGSNHSFVTGHHYVEILFIFLTLLDRYPRHRDNWLAKQACETAKRWITFAHGQAPWDEYTLEAGQDEMQGKIAICDDFKGWHVKTLEEDEEEGKTYPAGPRRYAAWQCYNEALEALLGPDMSEEECRRKMDSASLNVLMYLLSLTRKDETNIEGGERLTSALAEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVE3</accession>
    <name>A0A0D1YVE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239482.1">
        <property type="nucleotide sequence ID" value="XM_016377912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVE3"/>
    <dbReference type="STRING" id="91928.A0A0D1YVE3"/>
    <dbReference type="GeneID" id="27330643"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03560"/>
    <dbReference type="HOGENOM" id="CLU_012334_4_1_1"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000007">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="599"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="741" mass="83992" checksum="320A3821F8F7CA30" modified="2015-04-29" version="1">MPVEGGGDAIDLSTRYWNANQPGTTWTKECPEFLLGISEKNKVILSKRDQDFDRITWDRCKELVSHNTIDRFQRNASQLRAYLDYIYYLKKEHGSVLEYVKEFRLKWEDITPSGKPPFEDASDWKILYNDWPYYVEEDITHLVVWTKFTIDEDEQTGLVTPEGTRQIEEFIQRTFLRKGVTRERIVWFKNWKSLKSVHALGNRSSSEEVRDSEGEDTTVVEADQGNAVLSHIISQLRPGADLSRVTLPTFILEERSMLERITNFMAHPDTLLPMPTIDDPVQRFVAVVKFYLSGWHIRPPGVKKPLNPILGEVFTCYWDYPDNTRGYYISEQTSHHPPKSSYFFMAPEHHIRVDGTLKPRSKFLGNSAASMMEGISYLRFTNRGKSKGGEKYILTQPNMYARGILFGKMKYELGDHSYVRCPENNLMADLEFKTKGWVGGTYNAIGGVIKNDKTGEVLFELSGLWSGEMYIKDVKSGQKRLLFDATHAKHAPPKTRPIEEQGERESQRLWLSTVKAVHAVDHETATTEKAKIEDRQREEAKRREEMGVDWHPKLFRRVHAGPGGSEEGEEDLEWVINAHLDTQDPKELVDRILSIAPILPGQGSFGRRDSVRTARSTASNGPTSSGVPSHKDAPNQGNTHENLIDFDSQPAPATTKKDSVSPENPRSDPQQAPVHQSTTINAPIGNTPKSSNLMDDDDGGLNEKMSGMKMQEAMVPQGSSKPLKRADTETSEVDVFVDAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0K1</accession>
    <name>A0A0D1Z0K1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241352.1">
        <property type="nucleotide sequence ID" value="XM_016376076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0K1"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0K1"/>
    <dbReference type="GeneID" id="27328799"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01716"/>
    <dbReference type="HOGENOM" id="CLU_042941_4_0_1"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW21136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="320" mass="36206" checksum="C0398B105CC9D6A0" modified="2015-04-29" version="1">MVLHASSDESAMPMLQQQNRDEEDIPLDDNASDITRVGYAAMYGKAAAVAAHVRERSPSNLSSWSDSYRSSTLTGTGTRRRRQWMTTDLIFVWFRWGVVVLLQATIILLLWGQNVATAACENHAHRHAAATAEKDAVLKGKVVETGDDINGIYKTLSHSYTYLKPDEDRFIPNMTSNDNRLEIRRNWDMLMPLGSGSVAIPEYKEHPLLGDPITDDPIRSGPLYEASWTHALHCLYYSVDSYHQLIVNGGSDDDNPYHASHCFEYLRNSILCNLDMTLEGSMSTPQDKERGQPHVCRNREEAVRWIEERRVDDLQDIVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z1Q7</accession>
    <name>A0A0D1Z1Q7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241797.1">
        <property type="nucleotide sequence ID" value="XM_016376521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z1Q7"/>
    <dbReference type="STRING" id="91928.A0A0D1Z1Q7"/>
    <dbReference type="GeneID" id="27329244"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02161"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="26319" checksum="3B06B623A1181377" modified="2015-04-29" version="1">MASQEGRNIVVTGSASGIGLATTLLLAARGATVWTVDMAQAPADELKPWIEKGKVHFEGGIDTSDRATARRYIADVVSRAGRLDGLVNNAGIGLFEGPIASDEAYDRMIAVNIGGVWNYGTAALRAMQVQKPLGPFNSRGSIVNIASGAGLRGVSGLAVYCATKHAVIGLSRAWQEDFGKFGIRTNSVAPGTTATAAFKVRVKEEEGFLETLPSNPLGRVAEPSEIANAVAFLLSDESSYVAGEVLAVSGGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAQ8</accession>
    <name>A0A0D1ZAQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230318.1">
        <property type="nucleotide sequence ID" value="XM_016385374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAQ8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAQ8"/>
    <dbReference type="GeneID" id="27338145"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11062"/>
    <dbReference type="HOGENOM" id="CLU_067182_1_0_1"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="219" mass="25118" checksum="FB6772BCBEAABE76" modified="2015-04-29" version="1">MLHFVDQSHTRNASAKRQQRRAARSHSARAVHRETRRRETIQHQSKHLTSKSSVVRAHGIQCEPMTSLRFIGALPAGRKDPFMSFVRPFKPIEHFLLDHYVAVVVPLMRCKEDINLYRDSMTKTWVPFALREVGLLDALFLLACRHMDHSHQNSQQQQYFVQLACQYKLSCTKSLREAISSEVVFSDATVGKTLMLAYDEVRDTELAHPPASGQVAHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZBF2</accession>
    <name>A0A0D1ZBF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_11329</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230583.1">
        <property type="nucleotide sequence ID" value="XM_016385639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZBF2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZBF2"/>
    <dbReference type="GeneID" id="27338412"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11329"/>
    <dbReference type="HOGENOM" id="CLU_041732_0_2_1"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="101"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="281"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW10367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="349" mass="38068" checksum="0D73758525E80482" modified="2015-04-29" version="1">MTQADNSDTVQDEYEDMPGGPGAPIPVSQLVGLAGLTDRDIKLVVEGGFHTVESIAYTPRRTLEQIKGISEAKASKLLNEAMKLVPMGFTTATEMHARRSELISITTGSKNLDRLLGGGVETGSITEIFGEFRTGKSQICHTLAVTCQLPFDMGGGEGKCLYIDTEGTFRPVRLLSVANRYGLEGEEVLDNVAYARAYNSEHQLQLLQQASQMMCETRFSLLIVDSATSLYRTDYNGRGELSSRQSHMAKFLRTLQRLADEFGIAVVITNQVVAQVDGGPSAMFNPDPKKPIGGNIIAHASTTRLSLKKGRGETRICKIYDSPCLPESDTLFAIYEHGIGDPQPKDDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZCC9</accession>
    <name>A0A0D1ZCC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_11651</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230903.1">
        <property type="nucleotide sequence ID" value="XM_016385959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZCC9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZCC9"/>
    <dbReference type="GeneID" id="27338734"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11651"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW10687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61758" checksum="8BEF55B72D618E6D" modified="2015-04-29" version="1">MALTFDVQHVAIVSAVAGVASHLGYFIRGEHHLEAFRLLILALISPVAIFAASKYYLVIEDKEAVQITVSSVIGYYAGLFGSILIYRMFFHRLRKFPGPSWAKTSKFYHVSRIARRKNNWLVRDSWHQQYGDIVRIGPSELSIIKPKAVPLLLGPGSKCTKADWYDMGKPIDSMHTIRSKQVHDARRRIWDQGFNAKALRSYEARILKYSKQLVDAITRESGKPLDVSKWFNYYSFDAMGDLAFGKSFNMLTTGKEHFFLQLVHQGQSPLGVFSPTPWLALILKELPFAMRTFHKFIKWCGLQVDERQKMKMAEPDVMSYIIDSASHAKNPTEARNWLQADCRLIIVAGSDTTAATLTNAFYYMTKDPSHIKRLRDELDGLRLEDGTFHFKDLQGAAYLNAIINETLRLQPPVPSGLYRKTPPEGISIDGIYIPGDINISVPLYTMGRSEAAFTQAKEFIPERWISRPEMIKYKEAFAPFSSGPYSCIGKQLALMELRDVIAQLTTRFNIEQGPGNKTSPEAGMEDIFTVALGSFDLVFTPRKDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZF67</accession>
    <name>A0A0D1ZF67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_10934</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds to ARF1 and ARF2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231848.1">
        <property type="nucleotide sequence ID" value="XM_016385246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZF67"/>
    <dbReference type="STRING" id="91928.A0A0D1ZF67"/>
    <dbReference type="GeneID" id="27338017"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10934"/>
    <dbReference type="HOGENOM" id="CLU_017092_0_0_1"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000003">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000024">
        <property type="entry name" value="VHS domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041198">
        <property type="entry name" value="GGA_N-GAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18308">
        <property type="entry name" value="GGA_N-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="11">
        <location>
            <begin position="41"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="13">
        <location>
            <begin position="197"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="538"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW11632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="71796" checksum="BEFEBCE26F1DF8A4" modified="2015-04-29" version="1">MEATSARMASRGQYQFDGFSPPQSTLQRFIYNACDPVANLEPNLALNLEIVDLVNSKKGNAPREAAVTIVQLINHRNPNVSLLALSLLDICVKNCGYPFHLQISTKEFLNELVRRFPERPPVRPSRVQSKILEAIEEWRQTICQTSRYKEDLGFIRDMHRLLLYKGYMFPEIRREDAAVLNPSDNLRSAEEMEEEDRAAQSAKLQELIRRGRPQDLQEANRLMKVMAGYDTRNKTNYRAKAAEEVAKVQQKARILEEMLQNHKQGDKIGDGDVFEELAAALQSAHPKIQKMCEEESDDAEAVAKLLEINDSIHRTIERYKLMKAGDVEAANKIARGTLGTTTGVGKNAANELSLIDFDPEPTATVTAPDTDTNGSLSLLDAGAPPSTTAPSKPHTVEDDLLGLSIGDSSAGLGTLGAISLGQNTTSGTPSGLIFSNTPSPSINQQAIPQPASRPNYDAFASLTSALPSSKPATPVPAVQQQRPVSQAHIDPFASLVSSSSRPATPGWQANLPQPTMQQVPANTTASTGVADDEWTFESALPVSTIVKVLSSDVEIEFEPRRLAGASGIQITARFSNSTAQRITGLHFQVAVEKSYSLQLKPQSGREMAPRARNAIQQEILLNGVPAGKGNVVKMRFKVSYEVNGQAQEQQGNVPSLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZH52</accession>
    <name>A0A0D1ZH52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial ATP synthase epsilon chain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232483.1">
        <property type="nucleotide sequence ID" value="XM_016383860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZH52"/>
    <dbReference type="STRING" id="91928.A0A0D1ZH52"/>
    <dbReference type="GeneID" id="27336626"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09543"/>
    <dbReference type="HOGENOM" id="CLU_187039_0_0_1"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000003">
        <property type="entry name" value="Mitochondrial ATP synthase epsilon chain domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8381" checksum="02FF29D02D9A0496" modified="2015-04-29" version="1">MAFAWKAAGLTYNRYLAIAARVVRRSLKEGPRLQAERRGEMDLRFAKWQGGKQGDNQSLGAANADAMAEHATSESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHX9</accession>
    <name>A0A0D1ZHX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_09769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232708.1">
        <property type="nucleotide sequence ID" value="XM_016384085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHX9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZHX9"/>
    <dbReference type="GeneID" id="27336852"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09769"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="81"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW12492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="590" mass="63622" checksum="FEA5AE5487D3004A" modified="2015-04-29" version="1">MADLDLVEKGPAPDLVRNSFDAYQGKIELPRAPTAWGRFVDSFKRNPNARMTTQAIDANGNVLKDQPPAEPALSMVLKGRHLQMIAIGGSIGTGLFVGSGSALATGGPASLIIAYGLIGIMLYCVVQALGELAVAFPVAGAFSVYASRFVDPAWGFAMGWNYALQWIVTLPLEIVAASLTLEFWSGSRDVNSAAWVTIFLVAIIIINFFGVRGYGEVEFVLSIIKVVAVIGFCLLGIIINTGGVPGSDRGYIGAQYWHNPGAFNAGFKGLCSVFVTAAFSFSGTELVGLAAAETENPRRTLPSAVKQVFWRIALFYMVSLTIVSVLVPYDDPQLLNGSSSSDANASPFVIAVRNAGIQAVPSIMNVVILLAVLSVGNSSVYGSSRTLAALADMGQAPKILGYIDRSGRPLVAIIVSSAFGFLCYIVAAGPDTSAQAFNWMIAISGLAAIFTWATICICHIRFRKAWHLAGHSVDDLAFKSQAGVYGSWIGLIMNCLILIAQFWTGFAPVGYADMSASERVKGFFEVYLAAPLVIVMYIGYKLVYRTKFRRTREIDITSGRREMNLAEILAEERKVQAAWPWYKKVWNTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIX6</accession>
    <name>A0A0D1ZIX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233038.1">
        <property type="nucleotide sequence ID" value="XM_016382335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIX6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZIX6"/>
    <dbReference type="GeneID" id="27335092"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08009"/>
    <dbReference type="HOGENOM" id="CLU_072993_3_0_1"/>
    <dbReference type="OrthoDB" id="2096797at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02233">
        <property type="entry name" value="cupin_HNL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047263">
        <property type="entry name" value="HNL-like_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43698:SF1">
        <property type="entry name" value="BLL4564 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43698">
        <property type="entry name" value="RIBD C-TERMINAL DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="48"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="136" mass="14690" checksum="C6DE0878F26EE546" modified="2015-04-29" version="1">MPRMQISHASRSGTPSVHGNKAIANAFTGNDVYIDPVLGAEGMSIANVTFTPGARTHWHTHEKGQILRVVTGAGWVCDFGSQPVKINVGDVIWCPPGTKHWHGADNDSYMCHQATSFGGVTWEEEVGDQEYAKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJD2</accession>
    <name>A0A0D1ZJD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_08129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233158.1">
        <property type="nucleotide sequence ID" value="XM_016382455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZJD2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZJD2"/>
    <dbReference type="GeneID" id="27335212"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08129"/>
    <dbReference type="HOGENOM" id="CLU_051534_0_0_1"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="297" mass="33075" checksum="47C2BDACA42F28CF" modified="2015-04-29" version="1">MAEYWKSTPKYWCKHCSVYVKDTPFERRQHEATARHENNLKRFLRDIQNSHEKGEREKERAKSEVERLAKIGGGSVQQALSASGGTVAKPSSAALGRKQGAALTAADQKRQWAQLAEMGIQVPEHFRAEMAMAGDWTVVSQQSVTGSQSEEKPLSTGVKKRKFEGQEEEEDAGETVARRGWGSTTRGYPGRDTTDIDDLLSGTIPLKKERAVSPTLEEKQLKAEDQLNREDKTAFSQDLDSKDASTKLEDLNETDGTSKGAPLKKEDSNELIDRSISKIPEETPIPVFKKKRKAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZKC8</accession>
    <name>A0A0D1ZKC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-coumarate-CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233508.1">
        <property type="nucleotide sequence ID" value="XM_016382805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZKC8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZKC8"/>
    <dbReference type="GeneID" id="27335563"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08480"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF424">
        <property type="entry name" value="ACETYL-COA SYNTHETASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="464"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="61808" checksum="EB5D7FD167A2DF29" modified="2015-04-29" version="1">MPHAARWGLTLPGTSIPSFMFGSADAALDNSERVYVNAKRPNEQYLTLHGYREWAKRFAAGLQLSGLKDGDRVMLFSGNAIFNPIVVMGSIMAGAIYNSANPAYTPRELAHQLKDAEPRFVLAADNCFDRAVEAADMVGLDKNRIFLYTNPPIDHTKRLESPQTQHQHWTKLVAGPDAGQAFTWEDPIASLSASRTAILIYSSGTTGLPKGVELTHRGVIANVLQLKQMQFSDADKSPRRNLCVIPLYHVLGLHYYTFTAPKLGIQTLLMERYNLPDMLDHIQRFKITDLLLVPPILVAMAKHPSVRDGTCDISSVRRVVAGAAPIGMEVTKQFEELFHGEVKVRQAWGMSETPAITLCWHDGDRQGTSSISIGELVPGCEAMLVNEDGQEVTRPRVPGEFWIRSPNMLKGYWRNIQATKDTITPEGWLKTGDIAYKDEGGKWYMVDRKKELIKVRGAQVAPAELEALLLEHPQIVDAAVIGIKTPTDDEDPRAYVVLAPNATTTAEDVVKYVNTRVSKIKHLTGGVVFIDAIPKNPSGKILRRQLRDRAAKGASASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZN92</accession>
    <name>A0A0D1ZN92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234528.1">
        <property type="nucleotide sequence ID" value="XM_016381426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZN92"/>
    <dbReference type="STRING" id="91928.A0A0D1ZN92"/>
    <dbReference type="GeneID" id="27334177"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07094"/>
    <dbReference type="HOGENOM" id="CLU_425796_0_0_1"/>
    <dbReference type="OrthoDB" id="4121114at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="144"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="353"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="557"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="643" mass="73870" checksum="DAC2A15B51BDB8C5" modified="2015-04-29" version="1">MASPIWPERSSYEEDTSRIPPGTFSRLSRFARDSALTPAGWLLSQLRSSTASQEPASGAKEDVEVSRSLDELSDDSPTMEDWDVVRVASPTERLSDNDVDVQEVKVARDYEQGDDLNDTTETEDDDSSGAQLHEIQFMRRDIIIAVMGVTGAGKSTFISLLCEQDIEIGHGQKSCTTNVGVYHFNLGGVRIWLIDTPGFDDTNRSDTEVLGDIAYWLARAYTQHMQLAGIIYLHRITDVRMQGSALRNLRLFKELCGQDELRSVILATTHWTHGEGNSVSEEVGRGRVKELETTKEFWGGMIERGSRVEKHDGSEASALRIVSNLVSRHDSVTLKIQRQMVDEKRSLFETAAGQELQREIIEERRKAEETLKKLKLDMEYALNEKDKEWQETIKQDRAALEARIDQRTKEMEALKINLAKLAAEKDEQFRKMERKWNREKADLESRLHQVVVRNRNSGDAHAGSATPTASDRPNRDIPMRYAWENGIGHVNETPGRAERTTLTTRLETPSRRPSRNQAPSGRGALSRLGEERETTVARLDTRIKQEDERILRTPRELARIETGRQEHERKLREHQEILARLETRTRQREDEWRIALEEAEEAEKRRIRQREDEWRIALEEGRRPRNGEYGRGRRNGDVENDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPL0</accession>
    <name>A0A0D1ZPL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234973.1">
        <property type="nucleotide sequence ID" value="XM_016381871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPL0"/>
    <dbReference type="GeneID" id="27334625"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07542"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="19"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="521" mass="57359" checksum="E05BFC77D1484E8A" modified="2015-04-29" version="1">MGHHEGVKKQKINAYNVLLLCFIGLGSMTYGYTASIIGTTLGQPSFIEYFDLATRSNGTDLISTMNGLFQTGGVLGTLMLPYVADRWGRKWAIAVPAIIAVISGAFLAGSTNIGEFLLFRFFAGAAAFMILAAVPIWMSEVVPVDLRGALVDVHAVFLLLGYTVQGWVGFGFYFWDGGAATWRPPLALQCAWPLFLLCGIYWVPESPRWLVMQGRDEEAKQILFRLHSNPNDPENEFANAEYYQIEKQIAIDKTLGNSWMHMIKKPSYRKRCLLAIGTTGIIQCSGVLVINNYGPTLYANLGFSAVKQLLYPAAWLTMALGINILAMATVDLFARNRYMAFGVLGCMVTLIIEAALVAEFVPSNNHAALQAAVAMFFIFQIFYGFCLDGTQFSYLNELFPSHIRAKGVCLGVSMISLMNIIWLQAAPTAFKTVGWKFYLAFIIPGTIGGFIMLFFFPDTKGVPLEEIAAIFGDADEVAIYQRDIEIDHTTHSIIAHGHEAEKVGVGLTENVEASKTTDNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPV7</accession>
    <name>A0A0D1ZPV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235068.1">
        <property type="nucleotide sequence ID" value="XM_016381966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPV7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZPV7"/>
    <dbReference type="GeneID" id="27334720"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07637"/>
    <dbReference type="HOGENOM" id="CLU_011017_2_0_1"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="624"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="740" mass="82460" checksum="AB6F65E25E0286AA" modified="2015-04-29" version="1">MNTPSTTMRACEACNAKKTKCDMVRPTCGLCQRTGRSCIFPTSRKPPRPSLKRTSSESSNTFSGNLNLLLSILGKPDAINLAANQARMLTTAQSATTQNHVTAAQGQDDVFESDLSVTTPSTSLHKTSAPSPSQTGAVGQRFPSQASSFDAVPDTIEPISEHAPQPSPTHPIQQPTVFVSYDVALDLIETFFSHIQPWLPLLHKPRFAARIQQQLEPGADALRNVSLEVRLLMMSMFGLAARFSNHFTFQGCSPLDRASIYMPAARQAYLDLRNQNNSSLLYLQGSILLAVFTYTDEMNTQAWILTGVCVRLAYEIDLYDIDGDFRNSPHHRDGMDHVEFEEMRRAWWLTWELDTFGSLVMQKPFAVDRHQFNVRLPLSDEDWFAERDVESQRLLTAPEESWKSLQGSRNQNPRAWFLIVNHLLSLVAQHLSKPHLSSESNIQLVSACNCLRLAWPSSFHILTSPPLFNQKSFPESNWIIGSHLMLTTTYTILFSVQPEPYPTLSPASGISQSSETKLSARVVYLPQIVALWPPEYISLAHPFFVCCIMPTRSEIGTQRLDGKSRVALDAVENSMELVISHFAQKWKLATDALTIFRFLRGATLDPAADQPLRRRFAAFFTRKTSSDNPRRNSTSQNGNDVSPGPVSQIGSESSLLPDPSNQIAISGASPGLTDFDAAHNQHRIARNQSGHDGSFFWMGQMSLRDDLYIDSAIGNQALYPYSPIFAHPLDNSSMFDYGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTL9</accession>
    <name>A0A0D1ZTL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_06173</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236338.1">
        <property type="nucleotide sequence ID" value="XM_016380511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZTL9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZTL9"/>
    <dbReference type="GeneID" id="27333256"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06173"/>
    <dbReference type="HOGENOM" id="CLU_012393_2_0_1"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="29"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="11">
        <location>
            <begin position="186"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="295"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="453"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW16122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="608" mass="68353" checksum="59206461E81FB922" modified="2015-04-29" version="1">MSSNPAAALARIDAGSLQDIFEEKPGRIQQPVMQCVQIKPIAASAGGQERHRVIFNDTRNYIQTMLAVHQNHLVEEKILRRGVLVQLLGYTANKVKSKRILIVTEIKVLEEFGEHEKLGDPKPLEVKPEDEEKPFPTAISSNGFYGAKQETPKPSRPMPSHPKPSSSSAHANIYPIEAISPYSNKWTIKARCTSKSDIKTWHNRNGEGKLFSVNLLDESGEIRATGFNDQCDMLFDLFQEGNVYYISSPCRVTFAKKQFSNLPNDYELHFEKDTTVEKAEEQDGVPQIRYNFTSISDLQSVEKDTTIDVIGVLKDIGETSQITSKTTSKPYDKRELTLVDNTGYSVRLTVWGKVAANFDVPPESVVAFKGVKVSDFGGRSLSLLSSGSVTPNPDMEEAHRLKGWYDSQGRSGNFATHANVQGASAGTGGRSDPFKTISQVKEEQLGMSDNPDFFSVKASIQYIKQENFCYPSCLSEGCNKKVVEIDPGQWRCERCDKTWERPEYRYIMSVNVSDHTGQLWVSCFDETGRMIMGKTADELMEIKEVDEKALGDIFSEANCRTWNWKCKAKLDSFQEQQRVRYQINSASPLNYVTESQKLIDLIKQYGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZV61</accession>
    <name>A0A0D1ZV61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PV08_03795</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236823.1">
        <property type="nucleotide sequence ID" value="XM_016378146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZV61"/>
    <dbReference type="STRING" id="91928.A0A0D1ZV61"/>
    <dbReference type="GeneID" id="27330878"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03795"/>
    <dbReference type="HOGENOM" id="CLU_041707_2_0_1"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="339"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="139"/>
            <end position="167"/>
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    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="284"/>
            <end position="318"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="20">
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            <begin position="155"/>
            <end position="165"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022593"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
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    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
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    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KIW16607.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
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    </evidence>
    <sequence length="389" mass="42578" checksum="108CBCCC267A898C" modified="2015-04-29" version="1">MSQQPSPEPAAPSLEYPFAPSPDILRTHEKDAYVTGTISSQASTILRALLGARVAHKYSDATAHLSELLYLCLTTLLGNRTLGEEYCDVVQIEDDTLRLAGLGRRIGYIASVVFSPWMLGKTLPALRRKLRSKLERNIEHAQKKKKKKTTHDYGVGSGSGSGGEQHTGTGLKVQEYLLKHLDTLTSPNPLYALSLATFYFTGAYYHLSKRLFRLRYVFTKQIKPDEQRVGYEVLGVLLVLQMAVQSALHVRETYLDAATTTSGAPSGAEVSLSGARDHVLAAADTVDAPPPPPPSSSSKLSPGLAENTSTPVLDSNGARYDLSDPDVMAWIPAGQQRKCTLCLEPFRDPSATTCGHVFCWTCVQDWVKEKPECPLCRQGVLPQKVLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYJ0</accession>
    <name>A0A0D1ZYJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_04922</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237943.1">
        <property type="nucleotide sequence ID" value="XM_016379266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYJ0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZYJ0"/>
    <dbReference type="GeneID" id="27332005"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04922"/>
    <dbReference type="HOGENOM" id="CLU_002472_0_0_1"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000008">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein Msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
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        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
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    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
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        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
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        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
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        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
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        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="937"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW17727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1093" mass="122290" checksum="B054A315C78395E0" modified="2015-04-29" version="1">MKPMQKKQQTLSAFFRKPAPTTVARVEEEDDDDDVQPPTAKRRRITPIENDLLKGVNDEVQQTEQDQNERTLRPVSASEQNIATASQDLLSTDRTSKYLFSSPPLQENQTGADQRRKEELHRRFVKKLGKPDSIAEIKRRNRALEEDGEENDEADEESTEDTPKPTARSKGVKKGGSKLTPMEKQVIEIKQANMDTLLVVEVGYKFRFFGEDARIAAKELGIVCIPGKYRYDEHHSEAHLDRFASASIPVHRLHVHVKRLVSAGHKVGVVRQLETAALKAVGDNRNAPFVRKLTNLYTKGTYIDDIEGIEEDNRANPALQSPSTGFLLCMTEVNVKGYGNDEKVHVGLVAVQPATGDIVYDDFEDGFMRSEIETRLLHIAPCEFLVVGEVSKATEKLITHLSGNKTNVFGDKIRVERVAKQKTTAAQAHGHVSTFYAERLRDTRSEQNTAIRIFDKILGLPEHVLVCLSAMIKHLSDYGLENVFQLEKYFQPFSARSHMLLNGNTLTSLEIYQNQTDQSTKGSLYWMMDRTQTKFGGRLLRKWVGRPLLDQRLIEERLDAIEELLDPARAVNVEKLRHVLSKMKADLEKSLIRIYYGKCTRPELLNVLQSLQFLATEFGHVTEAASTGFTSHLLSSALTSLPSILTEVVGYLDKINLSAAKSDDKYDFFADSAETAEITEHKLGIASIQHDLETFRTTAADRLGKKRPVDYNTVAGIDYLIEVENSSATIKKVPASWVKISGTKKVSRFHAPEVVKLLRERDQHKESLAAECDKAYMTLLADISTNYQLFRDTIQSLATLDCLLSLASIGSQSGYVRPNFTKDIKIDVVGARHPMVEQLLLDSYVPNDISLSSDATRALLVTGPNMGGKSSYVRSVALVCIMAQIGSFVPCESATLGILDAVFTRMGAFDNMLSGESTFMVELCETSDILKLATERSLVVLDELGRGTSTHDGVAIASAVLDYLVRERKCLTLFITHYQVLARMEAGFENGELRNVHMRFTEDEERDSVTFLYEVGEGVAHRSYGLNVARLANLGQGVIETARCKSKELEDKTKAKQVGSMAKWLLEDAQGQQKDRMAAEDRLEWLVEGIEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYL4</accession>
    <name>A0A0D1ZYL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237973.1">
        <property type="nucleotide sequence ID" value="XM_016379296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYL4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZYL4"/>
    <dbReference type="GeneID" id="27332035"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04952"/>
    <dbReference type="HOGENOM" id="CLU_034574_0_1_1"/>
    <dbReference type="OrthoDB" id="2327445at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35828" checksum="8E38D6969FBDBC99" modified="2015-04-29" version="1">MGVFSRSKNTSPPSNGAKDESPSNYRKPRPTGLRIFTSLAYLLSTVFLILVEIGNINNNAVIRSTYFLRISLADIIPASWPNAIFINSIAQSIGLHDFYQVGLWNFCEGYDGEGITYCSPTETLYWFNPVEIILDELLAGASITLPTEVVDVLNLVKLASRWMFVCFLIGTVVSFLCVFVAPLGFSNRRPRWQHKARRIFLRQLPVTVLTFAALLFTAAGSVIATVMFAIFQDKFSGAEDLNIHAHMGKPMLAFMWVATGFNLVGFLMQIGTCCGVCCCTGRRRAERKSRRAGAGVASPVTEKDREDSPREPGKFGFRRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0J4</accession>
    <name>A0A0D2A0J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238703.1">
        <property type="nucleotide sequence ID" value="XM_016377133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0J4"/>
    <dbReference type="STRING" id="91928.A0A0D2A0J4"/>
    <dbReference type="GeneID" id="27329858"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02775"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="272" mass="28542" checksum="1C2E6D5A634630A4" modified="2015-04-29" version="1">MDRFVAETDAYRQHSVQDLLSLQGKTAVITGGARGLGLAIARGCAELGANVAALDVLKEPSAEFSNLTSDLDVTAKYYSVDVTDDHALRATFEAIAAEFGSIDCLVTAAGVGQGGPLVDYEKSVIDRIISINVTGTILSSQLAVRQMMKQGGGGAIVHVSSIGGHAGIPGQTNSIYCASKGAILAFTKSLAVELAESNIRVNSISPGFFLTSMTPGYLKQDLALLEKFEKSMPMKRFADRSELKSTVAFLLSPGSSYITGQDIAVDGGILAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A1I7</accession>
    <name>A0A0D2A1I7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239048.1">
        <property type="nucleotide sequence ID" value="XM_016377478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A1I7"/>
    <dbReference type="GeneID" id="27330204"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03121"/>
    <dbReference type="HOGENOM" id="CLU_068979_3_0_1"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008908">
        <property type="term" value="F:isochorismatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016291">
        <property type="entry name" value="Isochorismatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01398">
        <property type="entry name" value="ISCHRISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="199" mass="21285" checksum="D74D4205B43B5B6A" modified="2015-04-29" version="1">MAANKIVPSRTALLLLDLQVMYTKMDPKFEAVVTHTAPIIKAARSLGITIAHCRVAFTESEAAAVPDTNATFSRLKHDPSRAASYGVDSPPAAFHPDVAPEEGDIVVRKHRVGPFFNAPQDVHAIFKGRGIDTLILGGISTGGAVAATVVQAADLDYRLFVLSDACADREQETHDFLLTFFAKRGTVINSTELNSLIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A2I5</accession>
    <name>A0A0D2A2I5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_03444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016377798.1"/>
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    <dbReference type="STRING" id="91928.A0A0D2A2I5"/>
    <dbReference type="GeneID" id="27330527"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03444"/>
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    <dbReference type="OrthoDB" id="5511210at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
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    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
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    </dbReference>
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        <property type="entry name" value="Small_HSP"/>
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        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
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    </dbReference>
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        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
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        <location>
            <begin position="293"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
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        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
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        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW19152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="559" mass="61116" checksum="2DAC81B91AEB1DB0" modified="2015-04-29" version="1">MPPIYHLNPPPNPFWDFVAVLEDHPFFAQQRPNFAPGAPQRPGREQARSQPNTASAAAEASGNANSKPADVNVEDPPEVDPSTVRPERTDSHQQGMPFRGRGRFGNAFPTEDGDENRGDGCPGRSRHRHGRPHHHHHRRHGKGRRRSRSSSSSSSSSSSSDDNDRARENNAWTPFGGRWWRNRGPPGGPWRGGPTFGPPPFMAAGSRGPFAGHPNPAAFMGMGGPRGGRGGLHHHHHPPHPHGPHPRGPPSFGPEHGRTGGFNLNAFLNDLGERIGVDLSTAAEGLGLKPHRSSDADFEPRTDIFDADKEYTIHISLPGAKKTDLGVEYDGEHSLLRITGVVHRPGVDEEMMTKLVVDGRKRETGVFEKVVHLGTPRDPAKVDVQGITAKMVDGVLVVRVPKADQPFEHKTVNVSSSPEIPVEHPDEVYATERDLLFDAEEQAENDHPMHDAYTANDLPHSPAGQPYPAKASISSSSGGDSANGKRKEAEVERQRERSTTLDFEQANETVETLPRYEAEDTSVHSGHAKHDDDDNDGMSDWEKDGSDADEGEYVKINVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3Z4</accession>
    <name>A0A0D2A3Z4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016374507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3Z4"/>
    <dbReference type="STRING" id="91928.A0A0D2A3Z4"/>
    <dbReference type="GeneID" id="27327223"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00140"/>
    <dbReference type="HOGENOM" id="CLU_027006_1_0_1"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
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    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF17">
        <property type="entry name" value="PROTEIN SIMILAR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS_9"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
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            <end position="191"/>
        </location>
    </feature>
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            <end position="285"/>
        </location>
    </feature>
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        <location>
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            <end position="334"/>
        </location>
    </feature>
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        <location>
            <begin position="506"/>
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        </location>
    </feature>
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        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
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        <location>
            <begin position="263"/>
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        </location>
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        </location>
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        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
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        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KIW19567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="568" mass="61251" checksum="1ED397DDA6D64070" modified="2015-04-29" version="1">METVFITIHDLSRDARIKYCSDSIEDILGYLPNEVIGKACWEYFHPDEIPFAREIHDRGIELDKASVMNYARIKHKSGEWIGCECVFTVVHDVLVASTAIYRRGPRAQQRALDGAGVRRIFSSSPRDPRYHMLSFLSNKFSEEPTTPLPEPRAALFLNRFTRTSTIMYATSGVSTILGLDPEQIIGKSFYYCVQENCLRDAVKCLESAKANDSIAYLRFWYRNPLQPESRTHSEALPDNESDEDEGGVPLVGSERSGSTTSMADATTPRPTPATVDHQGTGSSSVQQLAPVVDNGVHRTISNNSTNTGSVGPVVSDDLNSDRRGSSQTPAEDLQTGPLEIEAVISCTSDGLVVVLRKASPLAPHTLELAEAPHFANGVFASPWAPEPVMPDSVVGAQDLTTTSFMTAIKEVAVFAWSLTGINGSLAQYARGHASGEALPPDGLPVWDPDAEVDEHYNAEYNGFLASAHRPFQSHGSLGVSRKEEDSTSSEDEVVWKRAPILPPWRRPKRRAHHDAFGGDVHDGVDGGTEDGGRKRHARSQDGSGTGSGSGSGSATGTGSGAGSATGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4F1</accession>
    <name>A0A0D2A4F1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2406 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239938.1">
        <property type="nucleotide sequence ID" value="XM_016374662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4F1"/>
    <dbReference type="GeneID" id="27327379"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00296"/>
    <dbReference type="HOGENOM" id="CLU_037541_0_0_1"/>
    <dbReference type="OrthoDB" id="5330253at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38616" checksum="06692E1DDA3E94C6" modified="2015-04-29" version="1">MTTMSQPSSDTRPRAHTAMSFSSQRTHRSSASGHKLELTESEKDKKRLHTKADPSMALSEATPAEQALERATVEDIRGMTHKDADGNLITDPDRSNPTRHRLERPLDTIRSFHAAAEGTSSRRSSFNNRPHSQIGQPGDTNRRASYYSANGFSPQGRPRPSPGGGYYRNSSYGFGPQSSVEESPGASQMYGRRQNSYYGASNGPQNGYYNGYQNGYNGESPVSAHSYQHSYETMTSGSDEYGKSTNPSSQNSSFDQLHQLSRPRPEGNDRNYSPDNPYANELKFGQSPAINKPFAPYNMNDNVPVNMPPNNPRKPIKLGGSEGAVDTPPESPQKKQSWIKRRFSRRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8I5</accession>
    <name>A0A0D2A8I5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-dependent oxidoreductase 2 FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241288.1">
        <property type="nucleotide sequence ID" value="XM_016376012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8I5"/>
    <dbReference type="STRING" id="91928.A0A0D2A8I5"/>
    <dbReference type="GeneID" id="27328734"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01651"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_1_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF315">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE MDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="6">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="486" mass="53965" checksum="85F8F53E74BCF0CF" modified="2015-04-29" version="1">MGDVKESPAVVDGVHRLPRNGIKVIVIGAGVGGLQAALECWRKGCDVVVLEKAESLSPLGDYFTITPSALTTLKDYPSMHADYHKCVYDCSIHVYTPSGLSIHSAMPEWKQPGAVHSAPDVDISFLKRRPVYAQMQLDQLNRLDIPVHWGEAVTAVREEDDLVIVVTSLGNQFVGDVCIGANGIGSKIPGFDTGPETKVQDSGYAAARVAFPRSTIEAGSLASTLFKNIDVQPEFRTYVGHDIHLILFLTRDWVAFTFTHPDYDSAQESWSNLKRPSELIPYLEKASDEWDPAVLDFVRSSPTGVVDWKLRWRDGTEQWTSDGGRLVRLGDAAHAFFPTSGNGAVQALEDTVSLAECLRIAGKKNVPFATKVHNKLRFERVSILQQTGFLNREELHNADIAAIKADRRKADIGFFRIGRWVWNHDPEKYARDNYAACLAHLTEGKPFRNTNIPLGHVYQPWSLDSENKRMQAGIKSNLKKNGDWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A9Q1</accession>
    <name>A0A0D2A9Q1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="16">PE methyltransferase</shortName>
            <shortName evidence="16 17">PEAMT</shortName>
            <shortName evidence="16">PEMT</shortName>
            <ecNumber evidence="16 17">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PV08_02052</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16 17">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16 17">Endoplasmic reticulum membrane</location>
            <topology evidence="16 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16 17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="16 17"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241688.1">
        <property type="nucleotide sequence ID" value="XM_016376412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A9Q1"/>
    <dbReference type="STRING" id="91928.A0A0D2A9Q1"/>
    <dbReference type="GeneID" id="27329135"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02052"/>
    <dbReference type="HOGENOM" id="CLU_005987_0_0_1"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000006">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 16 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13 16 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 16 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KIW21472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="980" mass="111152" checksum="137BAA5ED2A6C47F" modified="2015-04-29" version="1">MDPPAESAAEGLRKRNTPIHASTQQEARQAVLDLNAAEEQSDKKEQDRKTFGRTPDGTVFTVPYTHDMVSQLLSPTEPKNLGDVIVLLILLLHILLAWSLPAAYRKPVLAAIFLFWRAGYNIGIGYLLHMQSHHKMLVRWARRLKLFPSASNGENPHPQIRSFVKRELETKIAKDYDFDTAPLEYNTWLVFRRIVDLILMCDFVSYMLFAMSCGHRPDGELFVTTLLRWAVGISLFAFNLWVKLDAHRVVKDYAWYWGDFFYLVDQELTFDGVFEMAPHPMYSIGYVGYYGISLMAASYKVLFISIIAHAAQFAFLVLVESPHIERTYSSPPPRRSINELPIAAHGENHTYDLSTTDDVWPRPAHAQPSQTHNLLGLSNTDLYRTTDSAILVLQIYIFALTLLTPNTTFYQAFFVVNAAIWRIWYSAGVGYLLNRQSSKKKWTRHFLKYGESTGEAWRQWKGTYHLSMILCYAWFTAAAWKMYTIPTNWDYGLVLLKHVVGFSLIALQVWVSFSIYDQLGEFGWFFGDFFFDHSSKLTYGGIYRFLNNPERVLGLAGIWGVALITGSKAIFCLALLSHTLSLAFIQYVERPHMQKLYGRSLRQDAGLVRSLRRSLPPPLRHWQDGMDKMLDETFDYLEDFFDAVRPKLAAGVTSIVQDVKDLIPKHTARVTITKVEPEVVGLNPEDYNLEIEGTPASPLVDSQRSSDKESGLVRTAAEATSGQNALLFEYGAPIKVKWTAPLNHGAKDWVGLYMVTDNPSREVTTIPSSGRWIATNLQEYDLLNSEKGIISSNVKTTVKGKDGSEKECLTGEMIFSGDKLWWTQGVFEFRYHHNGKHNVMAISRPFEVRIPRFSEDDLEGTDSTATSAGTMLTQNDVLIRRSIESTLLPIVQNCFDRDPDIAPSTPSEAFGSLVDRDGKYAKRVVYAIHQMFGIEFAPQVVKADGKVENLAWRIWEAKKVLAPFSMSRSRGTSTPVESDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUD3</accession>
    <name>A0A0D2AUD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230296.1">
        <property type="nucleotide sequence ID" value="XM_016385352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUD3"/>
    <dbReference type="STRING" id="91928.A0A0D2AUD3"/>
    <dbReference type="GeneID" id="27338123"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11040"/>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000063">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986">
        <property type="entry name" value="BENZALDEHYDE DEHYDROGENASE YFMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986:SF1">
        <property type="entry name" value="BENZALDEHYDE DEHYDROGENASE YFMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="498" mass="52945" checksum="709931185AEAC5CD" modified="2015-04-29" version="1">MPPDSDHTNAKGSHSGSTFGLIIDNKDVNCGDVFEVLDPISQAPVHLAPAAVEEQAVAAVKSADIAFETWRDSTPLERRSLLLKAAEILQSRKDELVHAMVSETGAKASWAAFNIKTGIEFVLENAGMTTQVKGEILQSNHQGTLALVFKEPCGVILGIAPWNAPIILGIRAFITPLICGNTVVLKASEASPYTQYLLVDSFRKAGIPDGVLNFVCCPRSSAASVTEAMVSHPAVQRVNFTGSTAVGRIIASMCAKYLKPVVLELGGKAPMVVLEDANLEEACRAAAFGAMMHQGQICMSTERVIVHKSVAGRFAELLAQKVGSLVAADPRIDGAAALGPLINPTAGTRVQALVEDALSKGAQIRGGNFSVQGSIVQPLVLDGVRKGMDIYYQESFGPVVTLFEFETTDEAVRLANDTEYGLVSSVYGENIYEALAIARKIRSGSCHINGATVHDEPHLPLGGQKASGYGKFGGTVCIDEFTEDRVITIGTHGQHYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUK4</accession>
    <name>A0A0D2AUK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_11146</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230401.1">
        <property type="nucleotide sequence ID" value="XM_016385457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUK4"/>
    <dbReference type="STRING" id="91928.A0A0D2AUK4"/>
    <dbReference type="GeneID" id="27338229"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11146"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_21_1"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07866">
        <property type="entry name" value="STKc_BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000514">
        <property type="entry name" value="Serine/threonine-protein kinase BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="31"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="356"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="617"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW10185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="655" mass="75180" checksum="B6F55F49A41EB096" modified="2015-04-29" version="1">MSSESHRPHRTLERLPDGSPRFHGCSRIQEYEYLGKLGEGTFGEVSKARSKKTGQLVALKKILMHNEKDGFPITALREIKLLKQLDHINILKLEEMAVERPKNASKKPSMFMVMPYMDHDLSGLLENPDVNFSEAQIKCYMKQLLEGCAYLHENKILHRDMKAANLLINNRGILQIADFGLARPYHDDPPRPGHGGGEATREYTTLVVTRWYRPPELLLQLRKYTTAIDMWGVGCVFGEIFKKKPILTGNTDLNQAQIIFELVGSPTDETMPGWRELPGCDGITEFEPRQPTLNRVFRELPPLALSLLSEFLKLDWRKRINAIDALQHPYFHTEPLPARPSDLPTFEDSHELDRKKFRDQKQKPPPAPAGGSVGIASQGEWSLHGRPPPPHENRGPPGPRAPGGRPHANGYGHQGHGRRHPPPGQNGRHGGNDRRGPPPRDVPPYDQPHRLPYDEGYSRRPPMEHGMPPRQPVHENEQYRYGGTDVPPHRDDGRGLPPSRSRVPGAPSNAPPADNRRPVDDRDTYIPPYSSADSQQRPPHMKARRRDDRPPFRDGHYPHGPPDYGEPLRYDDSSAPGPDRERGRLRDIESMPMPPQGGTYERERDRRPRSRSPVPMRDWERDAHRDRRDRDREWEREREYRDRDRGYGMQDPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUU6</accession>
    <name>A0A0D2AUU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230709.1">
        <property type="nucleotide sequence ID" value="XM_016385765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUU6"/>
    <dbReference type="GeneID" id="27338540"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11457"/>
    <dbReference type="HOGENOM" id="CLU_071858_0_0_1"/>
    <dbReference type="OrthoDB" id="3438781at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238594" evidence="1">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="271" mass="28396" checksum="00084BEDCBC710CD" modified="2015-04-29" version="1">MNSLPLICVIILSLMNFSLCASAISSRQLCGSSYTLCAPNGASSKDIPPVGPGLASLYLNLLETIDALGNTDQASDSPAPQEPARRASQMPLTLCCAATTQCLLVTGYHTPCCWDRFTTNFFFADGAYGSITTGNYTTPEGDHANLITGNYELANGNMGNMYQRQTTSEANTRTLATPTPWTSTGIGPAIPASLVGSYLSLSSSAPTFAMNISTLVANATTSGTPSNTGTATVVPSQSHVTVSVTNGVPRADCRRGNCYWAMLSLVTYLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AV03</accession>
    <name>A0A0D2AV03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230739.1">
        <property type="nucleotide sequence ID" value="XM_016385795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AV03"/>
    <dbReference type="STRING" id="91928.A0A0D2AV03"/>
    <dbReference type="GeneID" id="27338570"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11487"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36649" checksum="9DFD2D813CCB1C65" modified="2015-04-29" version="1">MFHTLRAFWNQSFFIPAPTVTEKNLPDQTGKVYLITGANTGIGYQVAAILYSLNAKVYVGARSESKATAAISSIKSLHPSSKGGLEYLHLNLSDLSTIKSTAEDFMRRESKLHWLDNNAGVMIPPSGSKGAQGMDLQFQTNILGPFLLTKLLLPVLKRTAESEPAGSVRVSWAGSLAVELGSPKGGMLWKKTPSSSEETLDDSKDIRTNYSITKAANYFLGNEFGKRFGERDGVLHNSYNPGNLKSDLQRHTPKPLLWLFNAMLYPPVYGAYTELYAGLSQDLTIKDQGAYIVPWGRRVSVRKDLEDEVAKEDGQAAKLFEWCDRVTREYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AV42</accession>
    <name>A0A0D2AV42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230571.1">
        <property type="nucleotide sequence ID" value="XM_016385627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AV42"/>
    <dbReference type="STRING" id="91928.A0A0D2AV42"/>
    <dbReference type="GeneID" id="27338400"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11317"/>
    <dbReference type="HOGENOM" id="CLU_046006_1_0_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF19">
        <property type="entry name" value="LYASE (GLO1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="37"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="260" mass="28826" checksum="97ABEBEADD185571" modified="2015-04-29" version="1">MSDEAGPVTPFAHGAFLPNGHNTDPPLPADDPTIGYKLNHFMMRIRDPKQTMKFYIDLMGMRTVFTLNVGPFTIYYLGYPQTAEHRADLPKFGLDTATNLQHTLGLLELYHVHGSEKQEPGYYSTGNTPPALGFGHLGFTVPDVPAALKRLRDAGVEVIKDLGVCDRPSIPVSDWENERGVGVEVKGTESEIHDEYAKVFKKIAFVRDPSEIITARSKEQQTSGAKNNHSKGQRANFFCSRGQDGYIVELVPQNVDPKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AW55</accession>
    <name>A0A0D2AW55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11674</name>
        <name evidence="1" type="ORF">PV08_11827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230267.1">
        <property type="nucleotide sequence ID" value="XM_016386135.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230926.1">
        <property type="nucleotide sequence ID" value="XM_016385982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AW55"/>
    <dbReference type="GeneID" id="27338757"/>
    <dbReference type="GeneID" id="27338910"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11674"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11827"/>
    <dbReference type="HOGENOM" id="CLU_987058_0_0_1"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="283" mass="32189" checksum="809565D0CEB50E18" modified="2015-04-29" version="1">MSPDQTAQKSVGFLDLPTEVRHKVYKDLFCHRALPIPLGSGSLAPLQLQHKIDLDEPVFHTALFRVNKDISTDAIRFAYSVNSFQLPSDLTSFCRLGSTALASIRSLTVYNNCWLAGRESQAVWDIINHRCSSLELLVVQPSTHLLWQAIPQLKKYVAEFDWAKASRPRLVFHLYVFDRHFSFDLPEREYQRALQELKGAEGDHDGWYGFLKPGEMVSLLPRHVKQINCVLDVSAGGIHALDEVIRDSSDLPLIKMTLPASTKTFRHGSRDQLCYVWGERNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXF2</accession>
    <name>A0A0D2AXF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231609.1">
        <property type="nucleotide sequence ID" value="XM_016385007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXF2"/>
    <dbReference type="STRING" id="91928.A0A0D2AXF2"/>
    <dbReference type="GeneID" id="27337776"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10693"/>
    <dbReference type="HOGENOM" id="CLU_040551_1_1_1"/>
    <dbReference type="OrthoDB" id="1705416at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31801">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31801:SF0">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="395" mass="41979" checksum="BDA80C883868C1AF" modified="2015-04-29" version="1">MSYPPPPGSGQPYGGYYPPPPENTQAYPPPPISPPANANYFPPPPSGPSPPPNPAFPPPPISQISQTPSPPPLRQPTAQRPYNYGAVPASAPAHRTTFDHAAIHQRQPSYDGPPQPEPEASTLQEKSATSPQLRKLTKEMGNMLKAPTGPRMPGVPEGGQFVGVQGTSASDDVGTFNGGSYRISHRDTNSIITIQLAMGCPITAKPGAMISMSPSVTLKGAFKFSMKKMLIGGEMAHSTFTGPGELLLAPSTLGDLTMLRLSGSETWSVGRDAFLACTQGVIKEYKHQSFSKAMFSGEGLFVYKISGTGLLWMSSFGAILRKDLVEGERYIIDNGHLVAWNCKYVLERVASGGIISGLSSGEGLVCKFSGPGTVYMQTRNPSAFSAFISGSSYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXG5</accession>
    <name>A0A0D2AXG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231346.1">
        <property type="nucleotide sequence ID" value="XM_016384744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXG5"/>
    <dbReference type="GeneID" id="27337513"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10430"/>
    <dbReference type="HOGENOM" id="CLU_009601_2_1_1"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="637"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="779" mass="85841" checksum="57B8452D3FDFBE80" modified="2015-04-29" version="1">MPFFRDLRRRSRASFRTSDSSTDSNGTVPTAKSSSTLNSAGGSVTPPSTYHANGSTSNVLATAKTNGDAPPIPPRPNVMVSPSNRNSMITLSPSISTGALRVPPPTSAYAPKITSILDNSVVYQKVLLVSGEIGDPSMKALDGNLTVHHDKDGQAFPPTNWPVSDSYFKALVYLSPGWNRIRFDFTSPKLSSISSASAPTAHASYMMLNYLPLNSAPPLHLVILAGKDSACTYDAVPQRAQNEGNDLSMAIRKFRMAAHLWQAFTAEQMYRYKFGRRCFRFDEEWQTGTLSMRDWETGQMKNETKVHVVRSDKTTAELRDLQYAQQHSPAAKKGELYSIAAEAVKKYFDIRPGQKQHVACLLLDAHWDPEAKTILGHAALGGTSDELGLAIFGSHALQSYPSCIEEVVPAFMDCTKTDPQFVANDCNESGSSWEAANIGIGAHLHEVGHLFGCPHQTSGVMLRDYVHLNRTFVIREAYSTRTKSPGIKVCRQEDECGWHRLDVLRFRYHPCFRIPGDEPLAQDDSIQYYPIGNGKIICSAATGIAFVELWLEGDDLCRYWIDFTNTDPRSSLAKQVILTESDLRGRLPEDKKKTKLALEIFSGGSRKERIDDLDSLFSKINIVNLPHSFDSRPGFRSKKLGHSQLEGSKPEELILESTCLQTKLLTSVKVYSGYALDGVEFCYEDGHSQLFGKRGGKPGGDEFFLDTRRGETVLGFYVRAGLWIDGIEILTSTGRRSGVFGNATGGSGHTLMAPRGYMLAGISGTCGPWIDGFQIIITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXP8</accession>
    <name>A0A0D2AXP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_10530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231446.1">
        <property type="nucleotide sequence ID" value="XM_016384844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXP8"/>
    <dbReference type="GeneID" id="27337613"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10530"/>
    <dbReference type="HOGENOM" id="CLU_169797_1_1_1"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013491">
        <property type="entry name" value="Tape_meas_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02675">
        <property type="entry name" value="tape_meas_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="65" mass="7235" checksum="9DC504106EF9931C" modified="2015-04-29" version="1">MNNQGQAAGQKEDYLDKGLDAVEKKFGQGKIDPQKSRGMNEKITDSAREMFEKATGKNVPEKFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZ20</accession>
    <name>A0A0D2AZ20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4484 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231931.1">
        <property type="nucleotide sequence ID" value="XM_016385329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZ20"/>
    <dbReference type="STRING" id="91928.A0A0D2AZ20"/>
    <dbReference type="GeneID" id="27338100"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11017"/>
    <dbReference type="HOGENOM" id="CLU_019791_0_0_1"/>
    <dbReference type="OrthoDB" id="2152680at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028115">
        <property type="entry name" value="DUF4484"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14831">
        <property type="entry name" value="DUF4484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4484" evidence="2">
        <location>
            <begin position="389"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="564" mass="62781" checksum="651000ABF8BA8956" modified="2015-04-29" version="1">MASPTQLRIDVGSDPPIPPIAALFLVNFDHRKGYTLGWHRTIENVQIEGVVEFKSLPSGLHNVEEDLVYFIHDDYAGLSAFVKKADEESERSARMAAVGVLVPLEQGRIGRSWRHAISLQQLARDQITDLKNTALLEEYWNRHKLQPDGSSTKSPADANGQRSNGYRKARSMSTATTFMPAQHKLMPHHPAATLLDAFRTFGPLLFPVYRAALLRKRILIVTDTPVEFCCNLVYNISILSSASESALSQLQSSAVPEPWLKPLYTVGVLDIPQLEETRRWIACTTDDVLSTKPNLYDVLVFMPLAGSEHASPKAFPRIVHSTPQLSKTFPSTSIKASERDFSRFVHLQQALHRYPRCHIGAGDTDEEQNDDAASVSSHSSAYFDNKAVIEPASWSKVAYTSLVWWASAGDRRAGLTDAEEGECEQDLSLLQDEGDDQTQEVALVAYFHRMTERLFGTVAAAVARTDGEEVHEEYHDQIDGDEDALGESTIDHQTGSGDQETEQLLSTKDGEPEIEITQEDMAAMGLDSWSTSDKRFVEEFIQIWWGRKAAVHAAVIECCGLRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZQ3</accession>
    <name>A0A0D2AZQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232424.1">
        <property type="nucleotide sequence ID" value="XM_016383801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZQ3"/>
    <dbReference type="STRING" id="91928.A0A0D2AZQ3"/>
    <dbReference type="GeneID" id="27336567"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09484"/>
    <dbReference type="HOGENOM" id="CLU_055842_0_0_1"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="465" mass="49598" checksum="1C931B4B421F3D44" modified="2015-04-29" version="1">MATLAAISTPARQPFGVLSDSKVRSLQSLKNRQNAITPSSAPSLKRRAASPEMGSDSENIDPNILDSLNKRKRSMFDDDVSASKANRYSLTVTSTTPSTSTSTSTKRRLETPNPRLDTYVSKPSSTAPSSAPAKAAAGRSPTRHRSSFLKPSSRRLNLPSFSRGTPAPALSLSAALSGTKKSSTSRHKVLQHSRRSSRGQTIQSSKPQSWFFDIYEETEETQDYRMNEWTMTQSATGLDISDDEGRASSKKTEKLDKGKENVDPGELPSAPVTRSMAAAAAAAAAAAASEEKDIMATDDNDEPRTPLADLNPANFYADGLDATSVVLVHDDEDAEAETDIEEDEAADAAQVAPAASRDFTFQASTMTAKVLEELGTPSLNEILSAPTPSYGTEGAGKVPFVGAGLDLDAATDKVDASIEIWESESAKDENEKADVDVDPHIHVYRPGTPGSIGVGDENVFALQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B113</accession>
    <name>A0A0D2B113_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232596.1">
        <property type="nucleotide sequence ID" value="XM_016383973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B113"/>
    <dbReference type="STRING" id="91928.A0A0D2B113"/>
    <dbReference type="GeneID" id="27336740"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09657"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="60478" checksum="3CA1822126BD3362" modified="2015-04-29" version="1">MINIPSTLLTAPPGFSLFVAIAFLSVVAVVAWEVISIRGPRTPKGLRRPPQPPGATLLGGHAHLWGAQVGNNPSQNPLVKWAREHGEIYEIRTGVERWVIVSSPEAVKEIFDKNGSVTGSRPALRVLNLLSGGYRMLLMPYGKQWRNIRAIAHRCLSIKSADAMKPSSSLESHRYLLDVLQDPDNFLSHVKRYTSSVIMFSIYGRRVLDLNDPVLGAIYDELSHFSEAAGQIHNVDKYPVLEYLPRALQWWRPKWEAYHQKEVELWMGLWNDLKKQLNAGVRTGCFAEKFQEEDYLAMGISEVQAAYVAGSMIEAGSDTTQLSMNSMILAMVAYPEVVPKAQKELDAVVGNRLPQFEDMSNLPYIRAMVKEVLRWRSVSNDHVRHVTSGDLVYKDYFIPKGTSVVINHWALHFDPELFPDPERFNPDRFYNSPVNGLTAGECIHTNDVKLRDHWSFGAGRRVCAGYNLAENSLLILTARLLWAFDVLPAVDKVTGQPVQYDVWNYTPTRLFGPKPFPVAFRVRSEEKEKIILAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4G7</accession>
    <name>A0A0D2B4G7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_08753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233781.1">
        <property type="nucleotide sequence ID" value="XM_016383078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4G7"/>
    <dbReference type="GeneID" id="27335836"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08753"/>
    <dbReference type="HOGENOM" id="CLU_1008432_0_0_1"/>
    <dbReference type="OrthoDB" id="5104314at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW13565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30807" checksum="67EC8722E63A2071" modified="2015-04-29" version="1">MAFQTRESHRGLRHWSGLLRTCSDLWRPQQPIQLDKLFEDEIRRSNVPFHDFSFLGDLVDGDSESLDDPQAPCLPETAIAPPVAGLDDHVQTLRYTPTSIPRFSQEDDKLSGSDSSGATLASAIHTSKTKHPQLSSDLNFEWLVQAAKHIAKFDSDATMELSSGQLPPKSLAAICVNAYFDNVQAYYPILREHQFQASWESLYDRNQKTHRVAQYILFCLVLTIGAASDGMKSAFSSPLDQFSCHLFQKACALVYVPMTESSLVALQVMLLLVRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5H7</accession>
    <name>A0A0D2B5H7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Murein transglycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_06721</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234156.1">
        <property type="nucleotide sequence ID" value="XM_016381054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5H7"/>
    <dbReference type="STRING" id="91928.A0A0D2B5H7"/>
    <dbReference type="GeneID" id="27333804"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06721"/>
    <dbReference type="HOGENOM" id="CLU_033459_1_0_1"/>
    <dbReference type="OrthoDB" id="5339822at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW13940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="46306" checksum="2DD9C25EE025EA5F" modified="2015-04-29" version="1">MKVTSVALTAASATVALAQPHNHGHRHFHKHEARDVSTVTSWAPGPTEYAYVLNGQPISAEEVCNGIEDNELKFVDGQDPGVCSSSSASSTWLDWTSSTTASSSSSTTSIPTTTATTTTTTTTTFAASSTPAEFWAAPSSSWSAPSSSSAAGWGSAPASTGGWGSQSSSTPSSGGSGVDSDFPDGTISCSDFPSQYGPVPLSYLGMGGWSGLQDLQIANGLVNTIVTGISGQSCTEGMMCSYACPPGYQKSQWPNNLQGASGQSVGGIQCKGGKLYLTNSALSSKLCIPGVGGVQAQNNANGVVAICRTDYPGTESETVPVELQPGETEALAVPDAGSYYTWQGKSTSAQYYLNPIGYPASQACQWGSPGTPIGNYAPINFGVGAKDGTTWLSIFQNSPTTSAQYQGTVELKGNLSGSCKYSNGQYCGVTGCNSQGCTVSIISGTATYVISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9E7</accession>
    <name>A0A0D2B9E7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235491.1">
        <property type="nucleotide sequence ID" value="XM_016379664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9E7"/>
    <dbReference type="STRING" id="91928.A0A0D2B9E7"/>
    <dbReference type="GeneID" id="27332403"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05320"/>
    <dbReference type="HOGENOM" id="CLU_010595_1_2_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40498" checksum="8B66ACBEBC81FF7F" modified="2015-04-29" version="1">MATHTPVSDAVVEPQADDSPQPGSPWNTDGNQYIEVDGPDDLDADSAYGTSIQSDLTSLASEITRGVWEHGRRYHSYGRSQYAFPNDEAEVERLDMQHAMQTHLLGDRLFWAPINPEGSRVLDLGTGTGIWAIEFADMFPGSSVTGTDLSAIQPQWVPPNCTFEIDDAEAEWTWDEDTFDYIHNRNFVCAIRDWPKLIRQCFQFVKPGGWVEWHEKYPYMSSDDGSLPEDSALFQWGVKFFDASIPFGADATSPRNLKRWMEEAGFVDVREHILKIPIGSWPKDKRLKQIGLLESVNMTEGIQGLTMMLFTRCLHWTAAEVEVFLSRVRKDVKDRTIHCYYNFYVVFGQRPEGPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAS1</accession>
    <name>A0A0D2BAS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236254.1">
        <property type="nucleotide sequence ID" value="XM_016380427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAS1"/>
    <dbReference type="STRING" id="91928.A0A0D2BAS1"/>
    <dbReference type="GeneID" id="27333172"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06089"/>
    <dbReference type="HOGENOM" id="CLU_115063_1_0_1"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="87" mass="9465" checksum="238BAD4C2238C943" modified="2015-04-29" version="1">MKPVVSAFNAWTCTVVSCFAVVILSVIGSLFSRDHHMMMGMEEDPEDHAAVASAIFISVAVYAGFLVFCGFQAWLHVRASRRGAISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAU7</accession>
    <name>A0A0D2BAU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_05775</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235941.1">
        <property type="nucleotide sequence ID" value="XM_016380114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAU7"/>
    <dbReference type="STRING" id="91928.A0A0D2BAU7"/>
    <dbReference type="GeneID" id="27332858"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05775"/>
    <dbReference type="HOGENOM" id="CLU_026859_3_1_1"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000197">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="12">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="406"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="468"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="554"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW15725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="588" mass="64670" checksum="8B546F8FFD045CF0" modified="2015-04-29" version="1">MANRFVRSSKYRHVFGRSTRKEQCYDNVRVSKNAWDTNLVKANPEYLSVNWDSSGGGAFAVIPVNERGRLPERIPLFRGHTAVVLDTDWNPFNDSLIASGSDDGKVFLWRVPDDFTLHLDVPADEVKDIAPVGKLSGHPKKVGHVLFNPAAENVLASAAGDFTVKIWDIESGNAKLNLKVGEVIQSMSWSANGSLLVTTSRDKKLRIWDTRQEKPAHEVAGHAGAKNSRAVWMGEHDRIATTGFSRMSDRQLALWDVRAPEQPVDGFQMLDSISGVCIPFWDDGTQCLYLAGKGDGNIRYYEYEHDKFEYLSEYKSADPQRGVAFVPKRGVNMHENEVMRAYKTVNDTYIEPISFIVPRRAETFQEDIYPPTVGLKPAMSSKEWFGGAEGLPPKISMESLYEGQGVKEVPSDAPTPAKKAPEPIKAPEVRKEAAEPSPVTTSAIRSPPPTMKEQGATMMAVADKFQDTEPVEDDGDDDSSFEEVQKPTERISAAKPAGLEPKRQDSVPASSKLSDDVKAPDTKAVPTPTTAEPVVKSPSPVADEVGAEDDGDEIKNIKAMMAQQSRQINSLTETISELVAEVKALKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BB53</accession>
    <name>A0A0D2BB53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236061.1">
        <property type="nucleotide sequence ID" value="XM_016380234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BB53"/>
    <dbReference type="STRING" id="91928.A0A0D2BB53"/>
    <dbReference type="GeneID" id="27332978"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05895"/>
    <dbReference type="HOGENOM" id="CLU_024327_4_3_1"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="43321" checksum="056F9C0F9484DC83" modified="2015-04-29" version="1">MGEPFTMTALLRADDVGNRKPSRNDSAFIALVRNEELGGIVYSMRQVEQSFNSKFQYPWIFFNNDPFTDEFKRRTASETQAACFYEQIPKEHWDVPDSVDRDTMARRMAEMLSQGVKHASDLSYHQMCRWYSGFFYKHPALDNIRYYWRVEPWIQFFCAVEYDVFQYMSDNNKVYGFTINIYDDPLTLPSLWPQTLDFIAKNPQHLSHQMAWGWLTDSTGRPEHNARANGYSTCHFWSNFEIGDLEFWRHPAYESYFQALDRTNGFFYERWGDAPVHSIALGLFANVSSIHWFRDIGYRHTVYTNCPASDRCQGCQANKFAPVAFWLNGEDCRVCISGLTLQENHFLTPPGGTMIDYLRSSWPCSESVSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBR5</accession>
    <name>A0A0D2BBR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236241.1">
        <property type="nucleotide sequence ID" value="XM_016380414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBR5"/>
    <dbReference type="STRING" id="91928.A0A0D2BBR5"/>
    <dbReference type="GeneID" id="27333159"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06076"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="451"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60885" checksum="C103446ECD9BE9CA" modified="2015-04-29" version="1">MIFTSDYQIDIPNQDILTFLFERTRFKDNDPIWLDALNPNLNVTLGQARDLTHRIGRGLRDLGIGTRHGGEDIVLSFVENQVMVAPTLLGVLCAAGIHATCPMTATPFELTRQLKLSSPKILICSPQTRQVAEEAAAQSGIRGIRLLVMKSELLDIVDENGKSIVSRSYLQWRKITDKAELESTTACLVYSSGTTGVPKGVKITHYNIVANLLQMAFHFDHFANKAISEGEYLRMPGIMQNAVVLGITVQTMMAMQCGMQVYMFKKFDFPYLIECIRKYRLSTFFMVPAIWNRISNECTREDLVGFRFVMSGASPLPRELQEKMQKMLPEGVIMRVNWGMTETTTGAAQPAPMETGTEGSSGRLLPNMQAIIIDTEGNRLGPGRSGELCVKGPNMIREYFKNPEATKGAFTQDGWFRSGDIGYFSEDGKLFIVGRSKELLKYKSHQISPTEIEAILGQCPGVADIGVIGVPDGNGNDLPRAYIVASKSSVSEKDIHDFLHVKVSTYKRLRGGVRFVDEIPRNVNAKIMRNVLKEWVENEMIPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BC73</accession>
    <name>A0A0D2BC73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236441.1">
        <property type="nucleotide sequence ID" value="XM_016380614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BC73"/>
    <dbReference type="STRING" id="91928.A0A0D2BC73"/>
    <dbReference type="GeneID" id="27333359"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06276"/>
    <dbReference type="HOGENOM" id="CLU_066893_0_0_1"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="301" mass="33953" checksum="50C40FB38AE711E8" modified="2015-04-29" version="1">MSQSLNHLPPEVLLCILSFLDVPDLLQLSRTCHVLRDIACDPLLHLERIHHASHTLSVALARRPLKSSISPPNSWIWLSKTNVLSRQISKSLVRIRLSHNLEHRPSPHDLVERSILPSTCTTYSSLVSPALIQSRQAVERRRLMDGLGRKLERRPSMNSLISLNIMPEECARRNVSPAIVATRRKVIREGLKDGLRAWLEGRGLQAQKRKADELEAAEGNTVKTLVRRFAARKLALERAEKIDPVSLEKRRAQARWGREAEIAREAEAKREMADSGCTHPTRAHVLGLKKFWEGVIRAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BC77</accession>
    <name>A0A0D2BC77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236779.1">
        <property type="nucleotide sequence ID" value="XM_016378102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BC77"/>
    <dbReference type="STRING" id="91928.A0A0D2BC77"/>
    <dbReference type="GeneID" id="27330834"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03751"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="331" mass="35689" checksum="0879846F28719EC0" modified="2015-04-29" version="1">MSDKLILLTGGTGHIGFRTLVEALSKGYHVRAAVRSESKTTQIRTAKSVQPFLEQLEFTIVPDITKPGAFDDAMRSVNYVVHLASPLGRATDDFETNIIQPAVQGTLSILHSALKEPSVERVVITASLASVSPSTPRPFTADNTEEDPEGPFPDPFTAYVASKKLALNRTRQFLAQEKPHFSIINVMPSFVIGKNELATTPEAVNSGSNSRALGPILGNANAVALPGAVCHIDDVSFVHIAALDPKVDGNQNFGVNWRSSSFQWDDALEIVRKLFPEEVSRGIFPLGGSQSTGLAEFDASKTEDILGIKFKNFEEQILSLAGHYAEVSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDB1</accession>
    <name>A0A0D2BDB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-related protein RSR1</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_03768</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236796.1">
        <property type="nucleotide sequence ID" value="XM_016378119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDB1"/>
    <dbReference type="STRING" id="91928.A0A0D2BDB1"/>
    <dbReference type="GeneID" id="27330851"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03768"/>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000114">
        <property type="term" value="P:regulation of establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000631">
        <property type="entry name" value="Ras small monomeric GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW16580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="218" mass="25465" checksum="31AAF8769E1DBB84" modified="2015-04-29" version="1">MSLQPRREYHIVVLGAGGVGKSCLTAQFVQNVWIESYDPTIEDSYRKQINVDGRQIILEILDTAGTEQFTAMRELYMKQGQGFLLVFSICNMNSFYELAELREQIIRIKDDEDIPLVVVGNKSDMEEERVVPRARAFQLAQSWGQKPYYETSARRRTNVDEVFHNLCSQIIQRDTNRGHLQQLQHDQQLAARRQDRPNRHDRRAAGRRSRNRDRCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDL3</accession>
    <name>A0A0D2BDL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236931.1">
        <property type="nucleotide sequence ID" value="XM_016378254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDL3"/>
    <dbReference type="GeneID" id="27330987"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03904"/>
    <dbReference type="HOGENOM" id="CLU_011353_1_0_1"/>
    <dbReference type="OrthoDB" id="5392263at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="560" mass="61729" checksum="053EB543E87FE977" modified="2015-04-29" version="1">MGMLTPTLKPNQTAICGQEFNASIPAAPSVYVPYTFCKAKCDGPGISQFAKPSAWAAPIVQFILPAVIFSTTIPRRLKLGFKSQIATTPGRGQTAKRWLTFISTPFKGPIRLFLVVADNVFWIAAILMMAGPMMLSGVYEAVLDLKILAVLDSDPGQNFDEATVVELLLTVVAGNLHRSAQIDPLADIQQAIRTSVTAEAKRARLLGLVDSQMPYGAIVGAPVAFYIGNFVYTILDLKNKPSDQDAAISLAFGVEWMIIVHVAIIGSCVLATNNPSTSSVLSGRGNPRIAIRRATTTQNLAGQLPPGLWTRIRTGDLPFLVDMYDNRYQPVTMWSRGNNKEEWVRNSAAYRVQLRDNRRLMVGWMAKISILFVTAVLINLPLIAGAVVAWRTPPVGWGCRSLSFICYAGVQLLVTMLFIVLHKVPTPNEVVRGAGPAKGLKRYLGAGWYLIKVFWCGMAYAVFGVSLLLSLFVALGGTLMQVVGIYRNCFCYVNAPEWYNTDRAYVQVASDTQEQRDSSHNWIIFGGIATLFMAACCLVGWWYQARVRRRYKRIVNSRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDV3</accession>
    <name>A0A0D2BDV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04324</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237349.1">
        <property type="nucleotide sequence ID" value="XM_016378672.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BDV3"/>
    <dbReference type="GeneID" id="27331407"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04324"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1156"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1186"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1226"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1267"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1295"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1421"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="127"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="821"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="778"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1450" mass="160784" checksum="DE5643E57DAED2C5" modified="2015-04-29" version="1">MVSSSLTDQDDSDDCQITVAPKQSSLSEVHTRLSKTYSRGIEADRRSSAFNGSTLSKIRSHLSRTHSQATELEETEDEVDWRTLPGLTTASPVDRSLGLTWKNLTIKGAATGGTINENVSSQFVPPFLRKDRFTTTSVKTIINNSSGCVKPGEMLLVLGRPGAGCTSLLKVLGNRRKGFKEIEGQVMYGSFSHEQAEQYRGQIVMDEDENTFFPTLTAGETIDFATRLNVSHDGPTGSGSPEEARRATVDFLFRMLKISHTKDTRVGNEYIRGVSGGERKRVGILEVIAAQGSICLWDNSTRGLDASTALLYVQSVRKLTDLFGLSSIVTLYQAGNGIYNLFDKILVLEDGEQIYYGPKDSARSFFEDLGFVCADGANIADFLTAGVTVPTERRIRKGYEPRFPKTGAEIRARFESSAINRNMKAELDYPDAASTKELTANFADMVKREKHPGLLAKRSPYTVSFWSQLKASVRRQVQILRGDKTVLFVKQGSNIIQALTVGALFYNAPDTSTGTFLRNGTLFTAIVFNVFLAQSEVTDSFVGRSVLTKHRSLAFHHPAAWCLAQIITDIPIVLFQITAFSLPVYFMVGLTQSAGVFFTFWFILISVTFCLTAFFRAVGAGSKTFNDASKLSGVAVLSLLLYSGYMIAKGAMKPWFVWLYWIDPIAYTLNALLSNELHGKIISCAGPNLVPTGPGYNSPENQACTGVRGATPGQIAVSGEQYLDSLSYSHSHLWRNVGIVWVWWAFFVFLTILGTSTWQSISSQNGVLAIPRELAEKARLPTEDEESRGRTGATTPASSSSLGPIDEKRANERLNQNKSIFTWKNLNYTVSTAHGPRQLLDNVHGWVKPGQLGALMGSSGAGKTTLMDVLAQRKTDGTITGSVLVDGEPLPLNFQRSAGYCEQLDVHEPLATVREALEFSALLRQPGSTPREEKLAYVDVIIDLLEMHDIENCLVGHAGGEGLSVEQRKRLTIGVELVAKPSILTFLDEPTSGLDGQAAYNIIRFLKKLAAAGQAILVTIHQPSAQLFYEFDTLLLLTRGGKTAYFGEIGDHAATLKEYFGRHDAACPPDKNPAEHMIDVVSTRKKDWHRIWLESPEHDAMLSELNGTVEKVRGHHTHVADEDEEFATGLWSQIKLVTLRMTRSMYRNPEYVNNKFSLHIITGLLSGFSFWQIGDSVSDLNLRMFSTFQFIFVAPGVINQLQPLFIEKRDIYDAREKKSRMYSWKAFVTGLILSEMPYLVVCAALYFFTFYYTVGFSGESSKAGPSFFMMLLYEFLYTGIGQFIAAYAPNATAAALANPVVLFTMVGYCGVLVPYDQLVDGLRYWLAWLNPFTYLMSGLLLFPNWDVVIKCSENELAVFDPPANQTCAQYLEDYIASPYGMSSNLLNPDAQAGCQVCQYRYGSDWLRSLNIKERYYGWRDIGIVAIFVCSSYALVFLLMRLRTKKSKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDX8</accession>
    <name>A0A0D2BDX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_04359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237384.1">
        <property type="nucleotide sequence ID" value="XM_016378707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDX8"/>
    <dbReference type="STRING" id="91928.A0A0D2BDX8"/>
    <dbReference type="GeneID" id="27331442"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04359"/>
    <dbReference type="HOGENOM" id="CLU_276938_0_0_1"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="226"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="507"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1122"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1129"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1146"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1156" mass="129038" checksum="4F621F54AE55012F" modified="2015-04-29" version="1">MHLLTTLWSLQKLQNARSPGSYPSLSSLKPFARLRLATLRTLEPSILSVRCLHTEALQSSPPPSDDGIHWNPLDHPKTGLRNETPEAWTEQEESLPFEQQQQQPDGAENNGLTKAALGQTYTVQESRLFNLKLPPVNLQSSIETLKLARGLGLPEDELVLDPYDRAPPEGQPRSGKGRRRELAPAIRMRLAFLQKTSLPHMKEMAARRAKLPIAAHDQIVGEKSLINTINCSDVTVVLAKTGSGKTTQVPQIILENAILRNQGPDTTILCAEPRRIAATSTARRIAYERDEALGQSVGYQIRNELKLPNERGSITLCTTGILLHRLLTRGWPFLQRYSHIILDEVHERDAQLDLVLSLIRRHIQTLKECGLDYPKIILMSATIDPSSFLNYFVRSSEPGTLTACSFEVGGSGHPVNTLYLPEILNELAVGKDLHPTMQALLQGKTAKSSADYIKNELIYGALHQGTGQEANSEDANVGETCSVTAFDASTTSSVSTPSSHYLGLVTAVIAHLASTKPEGDVLVFLPGKLDIDTIYDLLRDMKPMGIDFEDERRFRIFKLHSAFRDTNDNVFTRVPIGCRRIVLATNIAETSITLPEVVYVVDAGKMRNSIYDPLTFKRSLPYEWISKTSMIQRRGRAGRVSPGNYYALFTEERCRTFRPMARPKITVSNLADVVLLLAAHPNHGDAGDSSSPREFLRGMIDPPSEDAIDSAYRDLQSLSALDSDGNITRVGAFLADMNVHAASAKGVLLGTVFGCLEPMVILACHDFNNPLIHNAELSIGQVRESKRHFDRDSESDLSILIDAFRQYHAASQAGDELLMSQLSEERCIKHSAYAEMMLTSQAVHQTLAKYGMVDPPAEGQTIFEAIPKFLNYNSDNMVLVKALAVNTVTAELAAWDATVKKWTLDIQNNGYPSRASILHEKTRSVRRTRRKYRTDGRLIAYAWKSSNDDVSDGAVWLENNSMVTPLMLTLFSRSARLESPQTIKFNDWLRIETRVDGVDDVFAAQSARIVMEARKMLDRFLNWTWTRILPNDEAGFEAAAKNVKAHFDSSATTCTIVKAITEMLRSDNDFWQAYRAERRADIEAEEAARAEQALMLAEERAEDMESVSNRFLLAPYVGEDVELRAEERKEEEEEEEEDDQEDEDDGRGGDDSDMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFG6</accession>
    <name>A0A0D2BFG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prenylated Rab acceptor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237964.1">
        <property type="nucleotide sequence ID" value="XM_016379287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFG6"/>
    <dbReference type="STRING" id="91928.A0A0D2BFG6"/>
    <dbReference type="GeneID" id="27332026"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04943"/>
    <dbReference type="HOGENOM" id="CLU_020822_2_0_1"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="51004" checksum="DE68939CFD972CF7" modified="2015-04-29" version="1">MPPWGRPPPGGRMRRQDDRLWGLQQRQWEYDTRVEELDTDDDYSQGVGLDQERFHSDELRFTGIDLGGDYVRRRRSGVVHDDDFTPSDDEEEEYDYPTGVARRQDMQVAYRDKEDMLVQRALDRIARARALGKPNVKLTRAEIDALERLERTQTPPRPSAAPKAAPKSKKEAQVRRRPVEVRKKPSRNDKSASNSPKGKPADGRNRGRSVASNSSSRGGREDSATSYVLPESDYGRRLSYSQGVSVVGPRQPDPLRQGSRTSSSQSLRQQHYLQQNAPYYSGRYASNPEAVYATGSRAPRPDPSEPDWEPRPRSASNIVNLPLDQLPYQTNAGMIPRFDPNDPRFASPQRRVASGPPSTMQNHAARYRRPQDELFLPPEEEPEVMRYLAPASDSEPEDDDDEDSDYGEGVRVNVNETPAGGYNIQTRSAAAAVATTRKPVASGKATTGRTKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGE5</accession>
    <name>A0A0D2BGE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238254.1">
        <property type="nucleotide sequence ID" value="XM_016376684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGE5"/>
    <dbReference type="GeneID" id="27329408"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02325"/>
    <dbReference type="HOGENOM" id="CLU_444829_0_0_1"/>
    <dbReference type="OrthoDB" id="4152101at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="603" mass="66973" checksum="504658B1028D651F" modified="2015-04-29" version="1">MDHSQLADLLAQTLPQKASNASVNRVQSLSPRQAFQSHVRTVNGRSSATTKPSPSALRSPELQQFSNLHVESTGPPPRSPARQTPFYGYTDADLHIARDGQPAFVAEEREAWARPSPLRIRKKPSNDIYVLQPPEQETPVKQPSKETRGLQQFGPMIDTADLNERPKTSRGPDAERASSDTHNDDDNHSQQLRNSKFAEGSMSHRSAGVSSTWHKHGSISSLSDLSDDEVTPKASPQRSSIDVDEFKPPAVTPSTLKQRLFKIGPTFKHNEKGGKTDAPLPGERKKKGLRKSISMWNLSHNGDKKKGRGADPDRDLAAQVATSSTPALVDKDTLNERKRRAEEAYAQQFGTKRRKSTGNQVPLPELSRPPRPLPVPELPPKTPRVHRPKPSLSSSAIATDSELSDGPSGIDHHKRPSRRELEKENQQLRAMLKQQQTRLKPDSAGVVPPVPAARTLDDLTNDIDPSKTRSASTSVRKQKLPPVPPVPDRVALRNLSNIRNQPKNKTSNTNTPSPNTNPSEKSNEQGNMERRPLTNINIAGLSRPVSVILEEDEEAIENKTPTPSPKRRVLEPSSVEKRKIRDQIAIQLRGVRREQWEWPEDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGH1</accession>
    <name>A0A0D2BGH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238294.1">
        <property type="nucleotide sequence ID" value="XM_016376724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGH1"/>
    <dbReference type="STRING" id="91928.A0A0D2BGH1"/>
    <dbReference type="GeneID" id="27329448"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02365"/>
    <dbReference type="HOGENOM" id="CLU_010170_0_0_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="623"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="756" mass="84061" checksum="FE39D85727870A0B" modified="2015-04-29" version="1">MPRPRVKDEDRKRVARACDTCKRRKEKCDGQFPCLLCKRRGREPECVFTEAYSKRGSTAPRKEKPAAQQPPSQPMTLKDALSDSNDAEIAIESLLTLSGSRSAPKSPQYDREQDGLISRAPVPKLARLLRDGRGKFIFVGDSSNLAFVQNIRRLVKAEIGECGLTSDPLRHAMCEVIPPHQIPSPLQTQHPKPTEAEARDLLKHYLLASSGVIDLFDPDEITEHLCVWTQDSTSDTDFNSAIYYLIMAIGAICRNAGDLDQAEFYFTRGREIGVPSFLEDPSVLTIQAYALITFYMLSATRRNGAFMLLGIAVRAAYALGLHRSDISNLFEPRERLARERVWKSLRVLDLYMSGSLGRPPATSEVDGGSVSWNKSTRDYEGIQMNGRNTSATLRICFIFERILNEVYCRREVSVQLVESISRQYRDWTMQLPAGLQADSLDQKAGTTAPTLRQTIGIAHLKCQYYWSIILLTRPFLIFKVSSKIKGRQDEDNTAGSSVTMTLSEACIDAALRSVEIATDLVHIPGVPKRLFMVANSVFISAMVIGFAIFGDFDKSFPLLSSIVQAESILAMMAKDDLSTRRHAEITKNLHLAALEHIKRRDQIQMQKRRQDILNIFGDPINKGNGVRSTGTTTGDQTPVDTGKAPLTDQTNGLGDFDTTEQLEDAPPPWQLRFDMPPESRGPVLTTSGALAYNGEDGGDQLQMLPRQDFSQMHDADGLSPDGSGVPSLPSYAEEFPLFSLMTDFDQLQDPFPLPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGU4</accession>
    <name>A0A0D2BGU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dihydropyrimidinase</fullName>
            <ecNumber evidence="7">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="8">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="7"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238444.1">
        <property type="nucleotide sequence ID" value="XM_016376874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGU4"/>
    <dbReference type="STRING" id="91928.A0A0D2BGU4"/>
    <dbReference type="GeneID" id="27329599"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02516"/>
    <dbReference type="HOGENOM" id="CLU_015572_2_0_1"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000217">
        <property type="entry name" value="Dihydropyrimidinase-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="62"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="8">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="561" mass="60915" checksum="BC54956E171BA122" modified="2015-04-29" version="1">MGEIGNESMDFDVVIRNATVVTASEILQPGLSIGIKDGIIVAIALFLPVGASTRVIDAEGAYVTPGGVDSHVHLHQDNAPTGDKWLTGSRSALAGGNTTILAFATQSRTQESLFPVVKEYHDRADGQSYIDYGFHLILTKPTEKILQEELKAMVDQEGITSVKLYMTYPAMKLGDGDMLEIMMQARALGVTTMIHAENSDMIDMITTRLLRSSRTLPKYHAIARPQIAESEATNRAISLSTLTSAPILIVHMSSPVAISHARKAQSKSLLPVHAETCPHYLYLLSSKLAATSVPAALSADPHHSHDHDHDHEEEVHDEWAGARHVCAPPLRHTPADLQTIWDAILNGTITTISSDHAPTLYNSPGGKRKPLIDAAASQSVPTFAQIPNGLPGLETRLPLLFDAATNVNAPRSRRLSLPKFVELTSTNPARLYGLAGRKGSIAPGFDADITIWYPPGHKDVAGGITITNDMLHHSIDYTPFEGMSVCNWPRYTVLRGELKWDRDVELREGHGRGVLGAPTDGAYLKRGKGEVLVGRTGQLPPGMRDGERDEWAAWTTHAQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BH84</accession>
    <name>A0A0D2BH84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stc1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238564.1">
        <property type="nucleotide sequence ID" value="XM_016376994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BH84"/>
    <dbReference type="GeneID" id="27329719"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02636"/>
    <dbReference type="HOGENOM" id="CLU_043829_0_0_1"/>
    <dbReference type="OrthoDB" id="4160813at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239111" description="Stc1 domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="52778" checksum="A1D5021F36458B4E" modified="2015-04-29" version="1">MVLGSAPDATPPWRSSAILALVTVLFVRRHALGPVASYSINSVVYTPAHESGQCKISPDPMTAPQHGLAFLEADVGPGIIPCASPCTGRNTHTVQYLGEQFLDSAEDPGKHCSQCTYPDTWCSRSRLYVATIHPSTLLGTTYSKEPQSIMASILERLFPVEQLEALGNKWPENAYKRRKLDDGARQQETWAVPAPRRQYRSSATPDPRYHRLSMPTQHSVKPRFTTQPTQIKRSNSECIPRTSPAPSASSTSNNSTSTQKSCLPAFIAPDLMLAYLHNLHPRDRPRYSLPGSPSSDTKADEPRRSITARHDNEDSISSPGSLTTDASSPQSSGEPCATPPSSAGQHGIVINGLRLTEHERGFMNDLLNLSPAVTDMLTSAPGEKRKMPLVDEEEDPASFFSGGNDAFEAMFGPSCAVEARFAGFEYAATTNDGREDDVHSSGLSPAAEENEAEDSSPAGIVMPVHTALSVDDFFDLEQAADEVSPLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHD0</accession>
    <name>A0A0D2BHD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230975.1">
        <property type="nucleotide sequence ID" value="XM_016384373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHD0"/>
    <dbReference type="STRING" id="91928.A0A0D2BHD0"/>
    <dbReference type="GeneID" id="27337141"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10058"/>
    <dbReference type="HOGENOM" id="CLU_060131_0_0_1"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF17">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_8G05690)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="234" mass="26977" checksum="F7AE103C4915C12B" modified="2015-04-29" version="1">MGVVVAPALIPDIEKVYDCYFEAFKQEPMAAVMLDILFPGGVTEEFRKAHTQATLDWWHKSTTQYTWKVLDTEKDEIIGMILADGFVSERSKEERKYTGLPWLHGQELERAEAVIRPLWEMREKLWGGRPYIYVHAIAIMPEHQGLKAGMALMLWGVDLADRSDLPVYIEASPSTWTLYERVGFERINERLVHKKELLGTDEDIEVPLMVRMPAAANGMTFDEWRANGYPPFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHU6</accession>
    <name>A0A0D2BHU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231160.1">
        <property type="nucleotide sequence ID" value="XM_016384558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHU6"/>
    <dbReference type="GeneID" id="27337326"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10243"/>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW10944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="561" mass="60345" checksum="3C0991F51169EC5E" modified="2015-04-29" version="1">MVNQVTASAGKDDDAFPYKQLAVVAICRLAEPIAFTSITAYTFVMVKDIKGEEDASFYAGLLISAFAMAEASTAMIWGNISDYYGRKPIILVALAGTALSSLIFGFAKHYWVALLARVVGGALNGNVAVMQTMVAEMIKKPEHEPSAYAVQPFMWSLGSIVGSALGGFTAQPAKFYPHLFSPDGLFGEYPYLLPNLVAVVAILIAMLQGWLFLEETNPRLRPSLGQPEQFRIEEPPISERTPLFRSRVRRGSAVESITVSLGRSSMRSSIRDSFSFASTTAPLPNDPAFDLRRGSLASMVSVASFKPLSGIAPQISDVVIEDDEDSAILQESVTAFNKPVIFWTVALVLMSYHQMSFSSLYPVYLLDDPHKSPGHLDLVGGLGLTLPKVGVFLAANSVLCLFFQGVVFPMFVGKLGIWKSVFSLAAITPLAHILAPFVSTLPNPGLGLWALLALQSFTCIIMFPSLLILLKNATESPLVLGKVNGLAMSGCSAARTVAPPLGGIIYSSLGSAAAWWSCAIISIAAIVQLFFAPRPEEDNTTILRRASVVVEAPPMADHVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHV9</accession>
    <name>A0A0D2BHV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_10258</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231175.1">
        <property type="nucleotide sequence ID" value="XM_016384573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHV9"/>
    <dbReference type="STRING" id="91928.A0A0D2BHV9"/>
    <dbReference type="GeneID" id="27337341"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10258"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000020">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000049">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="199"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW10959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="422" mass="47128" checksum="7DBF6140B749C4A5" modified="2015-04-29" version="1">MGDVLVDNPVHTVPPHKKQPLSDSIPDIDSLEGAGADGGDEYSTLKRLQRHLEYIKLQEEYIKDEQRSLKRELVRAQEEIKRIQSVPLVIGQFMEAIDQNTGIVQSSTGSNYVVRILSTLDREKLKPSSSVALHRHSNSLVDILPPEADSSIAMLGADEKPDVTYADVGGLDMQKQEIREAVELPLTHFDLYKQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTASFIRVVGSEFVQKYLGEGPRMVRDVFRMARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTSNVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFSTIASKMSLSPEVDLDSLIVRNDPLSGAIIAAIMQEAGLRAVRKNRYNIIQADLEDAYSSQVKGAQEADKFDFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ85</accession>
    <name>A0A0D2BJ85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238861.1">
        <property type="nucleotide sequence ID" value="XM_016377291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ85"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ85"/>
    <dbReference type="GeneID" id="27330017"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02934"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_1"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35446" checksum="C39302F65E256363" modified="2015-04-29" version="1">MPPAPRQPLKVPESYASLPLQHIKVSHVPESSRTATPVILITLNRPEKHNAFTDIMRQDMETVYELVNIDPRVKVVVLTGAGRSFCAGADLDIGFLGAKDEHGVVKNPKTERDVDHRDGGGRTSLAIHQCTKPTIAAIQGACVGVGITMCLPACIRIAYAKAKVGFVFSRRGIIMEACSSYFLPRLIGHSRALHLTTTGSVYPADHPLFGTLFSETCATPEGTLSRALELADEVATNTSTVSTKMMRDLMYRGPDSAEGAHLLDSRIIHGLFGSKDNIEGVESFLQKRKVNFTGQVPQDAPDGYPWWQQIDIGDKLLEKRQTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJE2</accession>
    <name>A0A0D2BJE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238941.1">
        <property type="nucleotide sequence ID" value="XM_016377371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJE2"/>
    <dbReference type="GeneID" id="27330097"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03014"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="61"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="541" mass="57318" checksum="6359CADA21EB98A5" modified="2015-04-29" version="1">MAFGVLQSARNPRPRGTVVLESIPSTSSTGGGGRLDLILVPTPSPYPADPLNWSRIRKELYFLTILFGACLTGVIGPVLVPGFTIIVATFNVSLTQVTLLNGSLVMALGVSSYLCACLAEVTGKRPVFLATSVLLVASSCWGAAAKSYGSLLAARIFQGLGMGSFFALAGTISINDVFFVHERGLRVGLWNSAVIASVNLAPVISSHIIVNLGWPWAFWILAISFGVLLVAVTLFFPETSYSRSVIEGENLVLVDHGHRTSITGSNIPEKVPHQDSTAPYQQDRELQQGDSEQLNGSLTLSSLLHPCPAPLGSFVDFLKAVATPLLLLRHPATIWACVMWSVTFTWVIIQGAVASQIFAYPPYNMTPTAVGNLIGIAPLIGSLLGTLIGGPLCDVAAVQLSSRNGGIYEPEFRLCAILVGGVVPFVVGAYGLGAAVAGGLSPATCGFFLAAINFAVGTSCTGIVAYSNDVFGEDAGEVFGLAMVVKSAFAFGLTFMFNDYYANHGPKVFFYTWGSLTVGALLFGTAFLYVYGKRIRAWMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK43</accession>
    <name>A0A0D2BK43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231860.1">
        <property type="nucleotide sequence ID" value="XM_016385258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK43"/>
    <dbReference type="STRING" id="91928.A0A0D2BK43"/>
    <dbReference type="GeneID" id="27338029"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10946"/>
    <dbReference type="HOGENOM" id="CLU_048444_1_0_1"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41337" checksum="1089581EF473B4DC" modified="2015-04-29" version="1">MSKPRVTPNPVEYTYRAPESARSGSTAHSIPHPEPISSATYHIAGILATVYGLGELDPAVTDVAVLWLLHPRLQTQACMAPFAAHIITNYNATKASSSSRRKQKGLIAVAFDQRNHGSRLVRAIANEAWRGGNETHAQDMFGCFAGTAVDTSMLLDYLPAYLFPDNSRQIVQNIVLGISLGGHAAWHVVMHDPRFSAAVVTIGCPDYVRVMSDRARLSKREAWLDSDGREFLGSRDFPSALVDKVRRVDPVGLLWHGSGLGRRSGQEQLYDGGELSPEEKETVIPIMARCLGNKRILNLSGGSDKLVSYQHSKPFLDWLKKSIEKGGWFEGSGLYLEDIVYPGVGHEVPPDMVSDMITFINETLEEGVEGARLGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLD6</accession>
    <name>A0A0D2BLD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239601.1">
        <property type="nucleotide sequence ID" value="XM_016378031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLD6"/>
    <dbReference type="GeneID" id="27330763"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03680"/>
    <dbReference type="HOGENOM" id="CLU_1865137_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="137" mass="14596" checksum="916CBF49BC2573B1" modified="2015-04-29" version="1">MTAVVESHNSGRTQAFALGKLRAKLLTGAISSDVDAAEIAAQVIRAFPDCNTNVLAGAVAWRDLCAMTGRLRTFHGSNSVQTTGKAPSAVESKGFCFDAEVKYGRPGGARSCVDTSTLRIQDYQLLFWLDVHCSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLV2</accession>
    <name>A0A0D2BLV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232380.1">
        <property type="nucleotide sequence ID" value="XM_016383757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLV2"/>
    <dbReference type="GeneID" id="27336522"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09439"/>
    <dbReference type="HOGENOM" id="CLU_524806_0_0_1"/>
    <dbReference type="OrthoDB" id="4897532at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="57909" checksum="07C66A5615E691B6" modified="2015-04-29" version="1">MANGQGRKDTSRPPILFINSQTELLTPQARRLARRHASWWGHRRSRAGQSADKPTLTSLSTPTSAGHSHTPSSSDNSCGSLCQRSPPVVGLSSPRQAAPLDCYLGSTHDAFHILPQLSIPSDDSNYLSSLKHDMHLFFGEAFVRNTILRSGDCCESRYAGCLLLYSTYRHAVTGHGSRASLLSLKGIVIRKVNSALAKPGQATTLDNMIAIMSLGVPMVCQVTASSADETTQSQSLARSSLDNVSDQLPPTRGGALGEKIAREYDMHYRAITKLMRMQEDPAWLVTTDGRYIFLTKVLSYAHWMLANSEETQESWSKILQKFELHSSKAPAQTGWLSPLYCPNVALWRMALGAEMPPKVTRLLLSFQTWYRLYRSGEDVAAHTASMRVLLQQDRLEIDVSNESYVESLSCHQEGELRYEACCIVISLMIEAEGDGCSISQAAPLVPKSRALSHILRRTDLAHLWGRCPGVLYWVILICHMVVKQDLEHRISTMVLAHFTQTLAASDIPLPVAIQPIKELLAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM26</accession>
    <name>A0A0D2BM26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239861.1">
        <property type="nucleotide sequence ID" value="XM_016374585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM26"/>
    <dbReference type="GeneID" id="27327302"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00219"/>
    <dbReference type="HOGENOM" id="CLU_571273_0_0_1"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="475" mass="53319" checksum="2E120E04284DD077" modified="2015-04-29" version="1">MVLRIEHVSWKTQRRESSKPNEESRLSVSATARKSSTARYLHLVVSDGELQVQAIFVPLSNARNSISLHNGGIIVVRKFSVRKAPRSNGQGHVIYLSVEEFVWIGSKREATDEAELESEGGFIREDVDGGNQHAVYHGIAGANIYRKPPPVRLAEASFSMDSPRNRKTGVTTGESTGVRAPPQRRHVHQQSKLRETDTAPDDEEDSFDTLAVSQSQIENRREALRQISQHKSAHTPAHSSLYYYSEGAGDNEDHDDEEEEDQDEEEEPKEGPFPPPAEKYVPLFPYVKSGNRKPTQTNTVTDHNPAMMERPLHSSVSLPIHTLASLLDSKSNLPRRSYACSVLAVISWVSPSLIYKPNTPFPPKRHIKIHDQTISDRQAGITVAVFVDAKDFMPAIGTVALLRGVVMQKFGEDVILNKYTTHPNPPGTIMEKPCDDKDWFVTDERILNDLGFDSTSLKTWWDERVRKRENSASLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMH4</accession>
    <name>A0A0D2BMH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232585.1">
        <property type="nucleotide sequence ID" value="XM_016383962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMH4"/>
    <dbReference type="STRING" id="91928.A0A0D2BMH4"/>
    <dbReference type="GeneID" id="27336729"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09646"/>
    <dbReference type="HOGENOM" id="CLU_087049_0_0_1"/>
    <dbReference type="OrthoDB" id="18595at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="5">
        <location>
            <begin position="58"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="256" mass="28547" checksum="610DEF26AECFEE5A" modified="2015-04-29" version="1">MFARPPRQTSSILTSLLRPSAPATASQSYICQPCRRQLHRGIPENGRVPPPTPFVPDVSTFLKLIGRDMSKHESKIGSWDELFTLSSPQLKERGIDPPRTRRYLLRWREKFRKGDYGIGGDLQYVQDGVAELRVVEVPTLKKDPVTGEPLAGPVSTSRSPGMQKLIVNVPNGSPTYALSPGQTTADLKKPMGFTLKNGYIIKGKQAHPLKGTYGSGVVLKAVEGLWEHKRGHKVHGGERRRAETLHKMRVEENKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMU6</accession>
    <name>A0A0D2BMU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_09731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232670.1">
        <property type="nucleotide sequence ID" value="XM_016384047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMU6"/>
    <dbReference type="STRING" id="91928.A0A0D2BMU6"/>
    <dbReference type="GeneID" id="27336814"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09731"/>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_1"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="13"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="410"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW12454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="468" mass="50637" checksum="CB19ACD3F490CDF7" modified="2015-04-29" version="1">MAASTRTETDAFGPIEVPSDKYWGAQTQRSLGNFKINQPQDRMPEGVVRAFGILKGAAATVNMRYGLDPKIGEAIQQAAAEVADLKLIDHFPLVVWQTGSGTQSNMNANEVISNRAIEILGGQMGSKKPVHPNDHVNMSASSNDSFPTVMHIAAVLDFEQRLIPALTNLRDALQKKVEAFDKIIKIGRTHLQDATPLTLGQEFSGYVAQLDRNLERIQTTLPHLRQLAQGGTAVGTGLNTFKGFAEGIAEEVTKMTGTEFITAPNKFEVLAAHDSIVEASGTLNTLAVSLFKIANDIRYLGSGPRCGLGELVLPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHTAATVGGLSGQFELNVFKPLLIRNLLHSSRILADAMNGFVEHLVEGLQADEKRIGTLLHESLMLVTCLNPVIGYDMASKVAKNAHKKGLTLKESAMELKALSSEDFDKYVRPELMLAPKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMX9</accession>
    <name>A0A0D2BMX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232695.1">
        <property type="nucleotide sequence ID" value="XM_016384072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMX9"/>
    <dbReference type="STRING" id="91928.A0A0D2BMX9"/>
    <dbReference type="GeneID" id="27336839"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09756"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_11_1"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF15">
        <property type="entry name" value="AMP BINDING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="497"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="63725" checksum="03767A01D8D8BCCF" modified="2015-04-29" version="1">MATESPIVPHHGDARWSLPADFQSQSRIRSLSSHSQSKSKPQLDISIPELPLFVQARSHALADPHKAAIIDTARDQSFTYSELLNDVAIFKAQIEQFLPPSPPVGEESRVAFLTPSGYDYVVMQWAIWASGAISVPLCTSHPLKELQYTISDSSPSLIILHPSFARFETGLREQAPTTPLITITPFSQSPSSRSTFLPKFTSAFSLSRRALIIYTSGTTSRPKGCVSTHETITFQAQSLVDAWKYTCQDHLLHVLPLHHVHGIINGLTATLLAGGTVEMHPKFDPSVVWTRWSERGTSTMFMAVPTVYSRLIDHFDSKIRGTQLEAGARQGANALRLVVSGSAALPVSTKRKFEEITGHELLERYGMTEIGMALSCGLERERRIDGSVGWPLPGVKVRLTSETGRVITSSGKDEAGNIEIQGPNLFAEYFNREKATAESFTEDGWFKTGDVAKRDADGAYFILGRESVDLIKSGGYKISALEVERKILGNEVLGGIVREVVVVGVEDAEWGQRVAAVVTLRDTTKAPINLKTFRGYLKEDMAPYKIPSILKIVDSIDRNAMGKVNKKQVLKQYFEPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP68</accession>
    <name>A0A0D2BP68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_00895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240536.1">
        <property type="nucleotide sequence ID" value="XM_016375260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP68"/>
    <dbReference type="STRING" id="91928.A0A0D2BP68"/>
    <dbReference type="GeneID" id="27327978"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00895"/>
    <dbReference type="HOGENOM" id="CLU_037769_2_1_1"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="92"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="291"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="361" mass="40776" checksum="8335DFDF260D63FC" modified="2015-04-29" version="1">MPSELEELVEFLHHGNTQIRQLACEHLVGHSSDPSVFKNPQLVPIQDLKLLVRDYAPIAKDALTILVNISHDAEILENLAGDDAFVETLLKKITNPKETAADEIAMLLSNLAKSERLERLISLERQTPDKSVSTSPYALDQLFDCFVKGAEGTLNKDANFDYLAYLLADMSKYKSGRDHFLSKREYDGVVPISKLTVFTEHKSNVRRRGVASTIKNVAFEVEKHPLLLADDSEMVDGVPGVNLLPYILLPLAGSEEYSEEESAAMLPDLQLLPPDKERDKDNEIIVTHLETLLLLSTTREGRDKLRSVQVYPLVRETHLHVDDEEVKQACDRLVQIIMRDEEQGPRIEEVVDDDEKIEEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ04</accession>
    <name>A0A0D2BQ04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240796.1">
        <property type="nucleotide sequence ID" value="XM_016375520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ04"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ04"/>
    <dbReference type="GeneID" id="27328238"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01155"/>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="7">
        <location>
            <begin position="433"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="65304" checksum="6F5D1FF3AE1D3ACE" modified="2015-04-29" version="1">MVHPATLPKNAPQLFDFIVVGGGTAGCVVAGRLAENRNVSILVVEAGPNNTSEIDMITTPARAFECRGSKYDWKYKTTMIDRPDYTRVEKPNPRGKVLGGSSAENYYTWVRGSAATFDDWAEYGTEEWNWENTKAYFDKPATYHDDDKLYPAELATTLNRGGPLHISHSDLIPEMKPFRDALEQAWVSKGQDLTTDVWNGTQKGLFKCVNTIYKGQRSTAAVFVEGKDNVTVMSSTISKNIVFEDGKAVGVTVIGPDDKEYTFKAKHEVIVSQGVYESAKLLMLSGIGPRTELEAHGIKVLVDSEHVGQNLLDHPILSHVFKIKDGYGLDSHLLRAGPQKDGAVAAYNKNKTGPYSSGLLELVAFPRADKWFETSKEYREYKAKNGGVDPFGPAGQPHFEVDFVPMFCDAFQWHFPTPPTGDYLTVIVDLMRPLSRNGYVKLNSTDPKEQPYINLNFFSDDLDLIALREGVRMIDDIVMNGDGMKDIIERDFPWDMPRNSDEAMIRQILERSQTGFHPCGTCRLGKDIKQGVVDPKLQVYGVQKLRVIDASVFPVIPDCRIQNDVYMVAEKGADLIKAAYPDLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQR9</accession>
    <name>A0A0D2BQR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_08672</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233700.1">
        <property type="nucleotide sequence ID" value="XM_016382997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQR9"/>
    <dbReference type="STRING" id="91928.A0A0D2BQR9"/>
    <dbReference type="GeneID" id="27335755"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08672"/>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239168" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW13484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="462" mass="50097" checksum="D63A44E91EE81B0A" modified="2015-04-29" version="1">MKPGRSSLLAPLVGLLSVANGISLEVSSLDSIKSVTSTLAYDMMTYYSGNQTGQTPGILPGPCESTACYYWWEAGAMFGSLINYWQYTGDDSYNPVVSQALAFQIGPDENYNPPNQSKNMGVDDQAFWAFSALDAAEANFPEAGGDIPSWIALAQAVFNFQQDLWDDATCGGGMRWQVYSFNAGYNLKNTISNGGNFQIAARLAYYTGNQSYADWAIKMWDWMEGSPLFQTQDGNLYIWDNTDTNNNCTDVAHYAWTYNYGTMLMGAAYLYNYTDGDPLWEQRVMSILKGAELLFFPQEYGGNIMTEFQCEPAANCNNDQSSFKAYLSRWMAVTTLLVPSTYDMIMPRLTASAAAAAQQCTGGNNGRMCGRRWYSNFDGSSGVGQQMQALSVIGATTIHAGIAPKSVKTGGTSKQDPDAGNDAASSPVKPPSAITTADKAGAGILTVLCICIIVGGSMWIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRB6</accession>
    <name>A0A0D2BRB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_08996</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234020.1">
        <property type="nucleotide sequence ID" value="XM_016383317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRB6"/>
    <dbReference type="STRING" id="91928.A0A0D2BRB6"/>
    <dbReference type="GeneID" id="27336079"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08996"/>
    <dbReference type="HOGENOM" id="CLU_000288_31_4_1"/>
    <dbReference type="OrthoDB" id="4153314at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW13804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="257" mass="29262" checksum="573AE0A1217A0628" modified="2015-04-29" version="1">MSVIAVRDYIGSTATFYAVEKGMIIKSIHPALAETDGYKLLVESKILKRLGEHPRVVKYRGYEDNSDLKGLLLLEASHGDLQHYIDQNNAKIDVPTRRKWCQQATEAVQYIHSKGIIHSDLRPQNYLVHETSNVLDLQLCDFGGSMCRDLDVDGRGLPDPPFWDLCWESTIGTDIFSLGSIFYTITTGLWPYKTSQEHEEDKWQFEDRVIALQEKGIYPDVEGIVGGTIMMQCWKKQYQKAEDVLEAQVMLSQGLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRG0</accession>
    <name>A0A0D2BRG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241874.1">
        <property type="nucleotide sequence ID" value="XM_016376598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRG0"/>
    <dbReference type="STRING" id="91928.A0A0D2BRG0"/>
    <dbReference type="GeneID" id="27329321"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02238"/>
    <dbReference type="HOGENOM" id="CLU_009665_1_1_1"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF7">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW21658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="429" mass="46801" checksum="5603418C07DEF9C1" modified="2015-04-29" version="1">MACLRVLIVGAGISGNALAYWLAKQKHTVTVIERHHCLRVNGLQLDLRGLGIEVMKLMGLEEAVRAKCVPEEGMGLVDPTGRKRAFFPANRSGAGAQSITSEFEIMRGDLCQLLTVAAVSKGVKYRFSTGVEAYMEKGSTVEVRLTDGSTQEVDLLVGCDGNASKVRRLMSGGGSLRGGEQDPALVMLPEKIAYYTMDEPMQKNEKYEAWGCVFPGPGKRVMATRRHNSDRIQMYLFVKDPSNGPLSNVKRGDTQEEKAAFIKLFRGCGWRAADAVRALETAAEDFYCQHTGVVKLDSWSRGHVTLVGDAGYGCPPDGFGTSMALVGAYVLAGEINRAQDTKAGGRDMLAVALKAYEETFGPCMKPIVKTYSAQASIFDRIPWTPFTLGLVTNALSIASYLRLDKLALKLMPNERGGWKLPRYEGLINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BS30</accession>
    <name>A0A0D2BS30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Short chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_01820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241456.1">
        <property type="nucleotide sequence ID" value="XM_016376180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BS30"/>
    <dbReference type="STRING" id="91928.A0A0D2BS30"/>
    <dbReference type="GeneID" id="27328903"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01820"/>
    <dbReference type="HOGENOM" id="CLU_010194_12_0_1"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="35368" checksum="0B518DBA7B5FD472" modified="2015-04-29" version="1">MNRALLSRSVSPLIKSFVPKHQPTQIFRKMSGPQTSHLPNEDLQASKLFDVTHVVAVVTGGGTGIGLMITQALQTNGAKVYITGRREEALDAVVKQYSKGPGSIHALPGDITKKEECIRLAEEVGKKESKGIHLLVNNAGIARDDHTKFSKNGQPDMKSAASISRHMLRSEVSDWQDTFETNITAQFFMSAAFLPLLAKGRDVTPGYTSSIVNITSISGLMKGSSSGQFAYATSKAGFVHLTRMLATTLAETGVRVNQIAPGVFPSEMTTGESDETQKSELTSKMSNPAGRGGGDADMAATILYLVGKGGLFLNNQLIHPEGGQLLVAPAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BT20</accession>
    <name>A0A0D2BT20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241761.1">
        <property type="nucleotide sequence ID" value="XM_016376485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BT20"/>
    <dbReference type="STRING" id="91928.A0A0D2BT20"/>
    <dbReference type="GeneID" id="27329208"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02125"/>
    <dbReference type="HOGENOM" id="CLU_087056_0_1_1"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="111" mass="12634" checksum="94F00AEE60D5077A" modified="2015-04-29" version="1">MARIYQIDIKTQEIKPSSDDTYTDMLELADDLPDSSPRYILLSYPLTLPSGRLSVPYVLIYYLPVNCNPNMRMSYAGAVELMRGTAEVNRVIEITDAEDLQEIEEKLKGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BX12</accession>
    <name>A0A0D2BX12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236060.1">
        <property type="nucleotide sequence ID" value="XM_016380233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BX12"/>
    <dbReference type="STRING" id="91928.A0A0D2BX12"/>
    <dbReference type="GeneID" id="27332977"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05894"/>
    <dbReference type="HOGENOM" id="CLU_031561_2_0_1"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="465" mass="52527" checksum="E2C02A8361372B79" modified="2015-04-29" version="1">MRYSRPLQDPGRTIDEYKSGMGDDIELGESVHAYVSSTRSSNNAGPSQSRPQRPSLSLKIPTFPSSRRNLEQPGSWQSRFSLRRHKRPAPRLLTKVVNLLRLCFMLLGILHCVAYVLGILSALFPDDFDLIPMPSREVLITPGSTGAWSEDLTADVQPLMCHSHNDYWRREPLHQALRAGCTGVEADVWYFDDQLYVAHTVSGIRQNRTLKNLYLDPLTEILDRQNQLPNFLGPLGETTRNGVFATRPMQSLVLLIDFKNDPDRIWRRLESHLTYFRDHKYLTHFNGTAVVQGPLTIVASGMAPFHRIVQSSTARDVFYDAPLDVLASLTGIRGSSAASLAHYAADADDPSLIDAPSYPQNAAVYSPANSYYASVSFARSIGYPWHSTLSQAQLDLLRRQIRAAHSRGLKVRYWGIPPWPVGLRNYIWRVLVREGVDYLSVDDVAAVTRDNWGPRKGGWGRKWWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZH7</accession>
    <name>A0A0D2BZH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236950.1">
        <property type="nucleotide sequence ID" value="XM_016378273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZH7"/>
    <dbReference type="STRING" id="91928.A0A0D2BZH7"/>
    <dbReference type="GeneID" id="27331006"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03923"/>
    <dbReference type="HOGENOM" id="CLU_044516_2_0_1"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="14"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="378" mass="40078" checksum="45D40D341AF6C007" modified="2015-04-29" version="1">MASKAMWEVDPETRAKLAQISKKEGAANDKCCDCGAPSPQWASPKFSTFICLQCAGTHRGLGVHVSFVRSVSMDAFKQGEILRMQYGGNKAWQDFFTKNSPIPFDECTIKERYDSEIGEEWKERLSAQVEEREFDKAAFLKERQAIKERQAARSATPAAAGARNSSANGQGGRTSSPAPGRGPGISAEQKAQNEAYFAKMGEANASRPDTLPPSQGGKYGGFGSGPVETQSSSGGIPSADDFSKDPVAALTKGFGWFSAAVGKQAKIVNDSYIQPTAKNLASSDLAAQARTAALAAGKNIQTGAKGAAESFNKFVEGQDEKASAAARRVEPERKDFWDSFGMGASGAPKPASSIGTSAMKKTPGASQKSKDDGWGDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZT1</accession>
    <name>A0A0D2BZT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237075.1">
        <property type="nucleotide sequence ID" value="XM_016378398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZT1"/>
    <dbReference type="STRING" id="91928.A0A0D2BZT1"/>
    <dbReference type="GeneID" id="27331132"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04049"/>
    <dbReference type="HOGENOM" id="CLU_006524_7_2_1"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="63172" checksum="A4DF4CCF3524DF27" modified="2015-04-29" version="1">MGGNSYRLFQWLMDTRRVAELEEKIDKLTNLLTADQSPQEQPNRPDVTINHHSLPTPPLSVGLDSRPLTTATGGSCASAGNINQKGKPCIDEDAVWQTDIKSIFRTTVPPVVEERLFSDFRTTFNRYFPYVVIPPHETTASIRKEKPFLFRTCVSVACHADPVTQSQLAEELLRYIGERMLIKSEKSLDILQGLLVFISWYQHYNHYNQQMMNLLHLASAMTIDLGLNRPTYSGPWPPIGMVVDTHQLIHGKPLCPGVQTSDERRALLGLYFFHARLSACFSRIDFMQWTQHIEDCCTSLLTSCEYPSDVEAVQGVRLTRLLERYSPYTGAISLKNVPIKTFVDCFQEDLHRVKREFPANLAHDPIFQMQIYDAELTIYETVAASERDAPLERAEALHAALGTIDNLIGTFAKVSAGSIPQLPFLSWIYVLHCYIVLAKLSFLVVDGWDLQYVRTGRINFPEMISRIVEVLEAAVRHSMGEKLRPNAISARYTKYAEKMRACSKWYNSKLKAETESSVDDLGSALPALDSTFEGFFEGFNDGFWTDISMDWAGTGMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3C7</accession>
    <name>A0A0D2C3C7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Catalase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238330.1">
        <property type="nucleotide sequence ID" value="XM_016376760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3C7"/>
    <dbReference type="STRING" id="91928.A0A0D2C3C7"/>
    <dbReference type="GeneID" id="27329485"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02402"/>
    <dbReference type="HOGENOM" id="CLU_045961_0_0_1"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08153">
        <property type="entry name" value="srpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024168">
        <property type="entry name" value="Catalase_SrpA-type_pred"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF62">
        <property type="entry name" value="CATALASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000296">
        <property type="entry name" value="SrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="1">
        <location>
            <begin position="9"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="324" mass="34687" checksum="037C8581F80DF397" modified="2015-04-29" version="1">MPLSTNEKTNETAATLVKTLQGAFHTPPGYRPAHARGILLTGTFTPTPEAGSLSKAVHFTQPSTPVLVRFSNSTGLPQIPDNANDANPRGMAVRFTLPEVNGRRQHTDIITHSTPFFPVRTGEGFLELLGAIGASSAPDAPKSPSPIEAFLAKTPSAKAFVEAPKPTPASFATENYFGVNAFKLVSADGKATFVRYRITADAGAAHLSDDEAKAKDPAFLHNEIQTRIIDGGASFTLSAQVANEGDTTDDATVRWPEEGHELVKLGSIKLEAIADDNDEKQRTIIYDPVPRVEGVEASDDPLIDMRASIYLVSGRERRAAGPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C4M1</accession>
    <name>A0A0D2C4M1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238725.1">
        <property type="nucleotide sequence ID" value="XM_016377155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C4M1"/>
    <dbReference type="GeneID" id="27329880"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02797"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="129"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW18509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="570" mass="63739" checksum="CF16ECACD251F3F6" modified="2015-04-29" version="1">MPDLIREAAFGQLMRWISGNRLFRYPEERADFQLPPQYQLLLGNGGTDAGINEAKLDRGLSLSHVPSRAETIPHSYERFDVEQQLEVEKTKSLSIAPRLTNDGIILVDWYTTDDPDNPLNWSDGKKSFVIFLLCFYTWVVYIGSAIYAASEEGVIAQFGVGHTAASLPLSLYVLAYGIGPLLFAPLTEIPIIGRNSIYIIPFILFFIISIPTAATNSFAALLVLRFLQGFFGSPAVANAGASFGDVYSIMYFPYALAWWVWSAWGGPALGPLLSGFAVSAENWHWGLWEMVWMAAPALVVLFFLLPETSAANILLRRAQRLRRVTGSPRFQAQSEIDQRNLTARNIAIHALIKPVQIMVQDQAIFFANLYTALFYATYFTFFEVFPLVFPIMYGFNLGETGLAFVPCQIGATPGLLTYFAYLRWYMIPDNKKNGLREQEHRLVPGIFGSFFFPIGLFIFAWTARPDIHWTVPILGIVLFVFGTFFILQSIFVYVPLSYPQYAASLFAANDLTRSSFAAGSVLFARPLFVNLGVDKGVTVLPSISVLGIFGMFVLYYYGASLRARSRFAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C550</accession>
    <name>A0A0D2C550_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238940.1">
        <property type="nucleotide sequence ID" value="XM_016377370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C550"/>
    <dbReference type="STRING" id="91928.A0A0D2C550"/>
    <dbReference type="GeneID" id="27330096"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03013"/>
    <dbReference type="HOGENOM" id="CLU_030130_6_0_1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000011">
        <property type="entry name" value="Cyanide hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW18724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="319" mass="35229" checksum="03365E813EFCE7FC" modified="2015-04-29" version="1">MDQEQAQSIRVAVTQCEPAWLDLQSSVQKTCDLIKEAQEHGAQLVAFPEVWIPGYPAWIWSRPADPELHVKYMKNSLVLESPEMKQIQAASAEHGISVSLGFSERSGNSLFIAQVTIDCQGKIVLHRRKMKATHMERTIFADACATSLKSVVQLPFARVGALSCWEHSLPLLKYNTHLQNEQIHVGAWPPLFSGSDKGQLWSMSREGCRTLSQAYAIEAGSFVLHTTAVLSRKGIDLMRTESGIVMHTPGGGSSAIIGPDGRILSADLPEEEEGIIYADIDLDEVLKVKGFLDTCGHYSRPDLLWLGANTDPRPLKRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C608</accession>
    <name>A0A0D2C608_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239185.1">
        <property type="nucleotide sequence ID" value="XM_016377615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C608"/>
    <dbReference type="GeneID" id="27330341"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03258"/>
    <dbReference type="HOGENOM" id="CLU_450579_0_0_1"/>
    <dbReference type="OrthoDB" id="4540247at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="709" mass="79109" checksum="909D6AE1E27665A7" modified="2015-04-29" version="1">MFGETHFIRSITVLKLAYPLYNHLATPLELYYNVGEQSIFTHPQEKPYPAAVDIDTEFRIELSLPADIPPGSSWKLMANWRNGATVFETLCTVPTAQPGEDIDDGPRPLSVKIVLKQLILDGKAKPLPWALTEVLYWKLEPLTPSPPRAISFSTWSTRDETSIPTRLYTSIPIELYVFPSNLPEFFHKGGIPLKLLRLPAYLPKWMRVSSWEQYKPYGPPQAPRHDVSRNVDLNWASFVVNAMFSESRLCYENWNGTYRYLSFGASSIRDLFSKNRGFDCWLDLWLYEISGYFTTQDISVNCYDLAALCQIIVALGVDTQQQDLRMKYMQPFGYIRPTFLIGRFEAQPNPDNPGSLCNNPFYGDPNRAPAMLCDHNLLNRSRFGNHMFLSLGQVMAIPNVLDACCGPQLGAVSLLDYPQAVVDTTTPLCALNGSSPGTIADITDGPGVGALVIARPFHWQDQTAPQADTVFGDVAAALNDKGNWREPLMMVPADARSVTAKMYCQKLVEVNSEGKITMDTITVEVSRYTNPYALIQDYNLRVVHFPAWTQSAVGGHEAPGTGLSVSGSLRMFADDKNLYLATIESISNKSPDTAALKLQLEKTLGNAFAKFDSKRQRIMSVSTQPADMPQAVGTKLTVSLQVSSTGDRYWKGYGVRLARSNVLFVRATSRAGVIDFEFLARTPGYDTAVITIYGGYFETDGKTVNFWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C673</accession>
    <name>A0A0D2C673_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03304</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239230.1">
        <property type="nucleotide sequence ID" value="XM_016377660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C673"/>
    <dbReference type="STRING" id="91928.A0A0D2C673"/>
    <dbReference type="GeneID" id="27330387"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03304"/>
    <dbReference type="HOGENOM" id="CLU_014631_0_0_1"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="371"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="893" mass="97950" checksum="8E3474CB34C3CD5B" modified="2015-04-29" version="1">MPPPPRGPELSPTSTTGSDGWSGLNNYNQIPRNDGAFASLNGPGDDYPSKAPPFPRPGANGANFPPGGLDPLGQRRPSESGSRGSSRAGSVAASRSSDGTLADDQSRKYRRMEAQLFQHYTVLKGYLKGGAQVPPRPNKARDKLLRLSPVQFHELSTDVFDELQRRQAATPLPGRPPRQQNVPPFLQPRPDFHEKRNQARQKLSSLQAPRFKDLSTDVFCELERRFPQFARSEGGRRESSRSHSRGPGSVASSNGGGGYGLPSRAQTFGPGPTGYSQRQESVTSIPQFDNPPVNDYGRPMAKQFQSNTITPNKSMMVEDEDETQATDSRYDRSSDAFGLESSLTSPRSDRDTSATSQSGVSYNPKPLPPVMTELQDKLADLEVNLEAKDAELRSSRAEAEKWKVTTEDLEKKLQAAENLNQSLKEEIEKLKVEQPNYSGESVLWKTKYLKLDQDHELLQNRLAQQQELTEEVRRQGQAFLEEMRAMAESGGNPDREQKLQADVSKLEEEVKEWKARYVKTKTQLRSVRASSLGLSIARPDANRQAAALQDREGLVKDVHVTKFQISIDELLSIARSDNPAAVLDHMKTVVLAVRGITSDVDAAITDKNDEITKKRAKMKSKVSVTANNLITASKNFASANGLSPVSLVDAAASHLTAAVVDLLHTVKIRPTPPGELEDDDDGTLEPLQSNGYFNIAESLRRRSAVESVYSALSTPPETRNGSMQIGHQRNGSSYLNGTGLGIQSTYGPSQEEADLEDLKMYLEDQTDGLVQSITSLVDAIRSDDATVPIQTHISTIAGTIENVVTAVERTSSEPSSYQTLLVEKSQPIVVILQDCREKLLQAGADAATYNGTQQSREVTQKLPPLAFQVARETKELVSRIMAVEAGRGEEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C861</accession>
    <name>A0A0D2C861_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239980.1">
        <property type="nucleotide sequence ID" value="XM_016374704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C861"/>
    <dbReference type="STRING" id="91928.A0A0D2C861"/>
    <dbReference type="GeneID" id="27327421"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00338"/>
    <dbReference type="HOGENOM" id="CLU_029940_1_4_1"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF2">
        <property type="entry name" value="HYPOTHETICAL POLYSACCHARIDE DEACETYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="353"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="628" mass="68878" checksum="14090058327ECB8D" modified="2015-04-29" version="1">MSEAKGSFLGLEGLHVFVTGAGGGIGGAAVKEFLALGCRVTGFDRRVIESSKLCSTPEEQSRFNAVQGDLTVEDSIAASFRSAVDRFGPVNILVANAGITDESAHPPIWEVDVALWDKVNTNNVRGTFLTVKHFLLSVKQAQETQGGELDNVAIVITGSETGKFGQEGHSEYASGKAGLQYGLVRTVKNEIVRLNSKARINAVAPGWVNTSLIGDRLDDPREMWSECQATVALKKISEPEDVARAMAFLASHRAAGNISGECVSVDGGMEGRLIWREEQVFGPGSKSGSTGSAIQTTVIPRSLSPPKRQRRLRICLSVDFDAISGYLGTGHDPNNTLADYSAGVFSANVGVGRLLNLFKKHGISDKLTWFVPGHSLETFPTQAQEIVQSGAELGLHGYSHEGAYAMTVEQEKDVLEKCIDIITKLKGGKRPVGYRAPLYQIRETTVRLLQDHDFLYDSSMNAHDSLPYFLPKPFPEEPPHVPDYSKDAKSWMVPTPIPQQPEAGSAEAENALVEIPGSWYTEDMTPLGFYPYSVNTQGYVSVDVVEKMWLDRFNWIWENESWLDEGPGKGYGSVYPMIWHPESAGRAHIVGMIDRFISKLVVRMKEADEGEITFESMESVARSWKQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8R0</accession>
    <name>A0A0D2C8R0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylisocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240145.1">
        <property type="nucleotide sequence ID" value="XM_016374869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C8R0"/>
    <dbReference type="STRING" id="91928.A0A0D2C8R0"/>
    <dbReference type="GeneID" id="27327587"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00504"/>
    <dbReference type="HOGENOM" id="CLU_027389_3_0_1"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF2">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="32969" checksum="48F7F150DA1B387E" modified="2015-04-29" version="1">MGSLTESHEPSKAAQRLRELLADPDQIIVAPGVYDGISARVALSLKFDVLYMTGAGTSMSRLGWADLGLATQHDMTEQAEMLANLNPSVPVIADADTGYGGPNAIARTVSKYARAGIAAFHLEDQVQEKRCGHLLGKEIVSREIFYSRIQAAVNARKELGLDILIIARTDARQSYGFDEALERLRRAAEIGADIVFPEAMASKQEAADMVRLMGQTPCLFNMVAKGVTPEVSVREAKEIGFRIVIYPVVGFGGAIRGIMDAMTTLKNDGREPEDLLGVKDAFALCGLNECIELDKRAGGTALREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAR0</accession>
    <name>A0A0D2CAR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein S-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_01241</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="2"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240880.1">
        <property type="nucleotide sequence ID" value="XM_016375604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CAR0"/>
    <dbReference type="STRING" id="91928.A0A0D2CAR0"/>
    <dbReference type="GeneID" id="27328324"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01241"/>
    <dbReference type="HOGENOM" id="CLU_003599_0_0_1"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="938"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="980"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="289"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="489"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="762"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1082"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1176"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="902"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1195"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1206"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW20664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1231" mass="138549" checksum="A1E915992F65D06E" modified="2015-04-29" version="1">MATATTEARPLRIKLTKAVTQKKDEDLARLLQDEDSSRRNDENDLRALLSKAISIGYEHGVKLLLDAGAKTDVVGNHGPLQNAIASANDKTRNAIITLLLDRGCELEAKDATGRTPLMAACLRGQSDVILTLLARGADPNLEDATGKNCLQIMASESKRKTDWSPEALSALLPKFKDLNKRDSHGREGRTPLLWAAARNQLTLVDALLKMGKGVADINQSNDQGHSALHLAARHDEPEMIKLLIFMGARIEARSDGDWTPLLMAAKEGNEKAIDALLTSKANVNARTSSGMTSLHWAADSGKLAALNRLLREPDALTNSKDSFDSTPLIRAAQNGHWDIVNALRPYVLKGPTNRIARKACERFRAAVVNFFEDKDGRGNVKHKNKVNKQTVWQIVYARNQNNPEKPAIPIALDQVEGKKPSFRWIHLPANNISWLEALLTRYYLESDTKDVTALKSLLRLLGRQQHRGSEIHSRFMRPSCKRIWIPPRQASEQTQATPQKLSHQNNRRAAPSTPPPPPSARSTAPAAAQSQQEDDMMVLFMPYLHWETDRNRTSLTQSLRAPAGNTDSLDDSELSRIAKDILLIHGYVSGSTDLHPRRTLDQFKHHSTKTDHQDADQVVYRYCKKRRKELKVFMVDQLWMISIGNLLISCFPERWKQPHRDPLNLFEGVVEDINSSTRPPVRNVFELATVITERCTGLFDRQQWDNDDLLFAEMFELSIGRLTRKETKLFRRFKEASSHWLRSHEGGGNVLYDSRMGLLDQEDDDHSSDWSSDELHDHHHHQHHHDGNSIRHAHRGTVPASDTTTAHRHQQMSGSFDNDLLNIDKEAALLVECKDVEDELDILTSVLHQQQQVLNDFDATLRTAKRLHHRLDLYNKVGEQRRLVDLDILDLGRMTRQAKSVNDNLTQVLDLKQKHANALEARFQRKQAEESVRQGQTIMVFTIVTIVFLPLSFLASFFTINIAEFPRPPGSQEGNLHLGWVVKWILGIGFALSVPLIGLAFVVGDVQTWWVNRKLDRHRRRKEKEDAMMMTRMDMGPGSGGVYGHHIHSTPDTSRGERRLSGGGGGGVDWLTGIIMRQRNVPRPWRRGGGGVGNRHLGLPVSRQRPIDGFDESNREGYIERATQQQQQQQAYRANGAWDGAAAATSRASHLDQRYYHQHQQHPRHDQPDAVSGLGLYQQQQGRQAMSSMESSRHGGNRFPRRLRRVGTETTERSAATEDLEVGSGGGGYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAT5</accession>
    <name>A0A0D2CAT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240905.1">
        <property type="nucleotide sequence ID" value="XM_016375629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CAT5"/>
    <dbReference type="GeneID" id="27328349"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01266"/>
    <dbReference type="HOGENOM" id="CLU_1120204_0_0_1"/>
    <dbReference type="OrthoDB" id="10674706at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255077" evidence="3">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="250" mass="25278" checksum="BF60D9AA1681F7E0" modified="2015-04-29" version="1">MARLANLFLALTLLVLPGVLAYDVNAFSLTAAVAMVPGFLAPAVSAYVVPPGGFNRLAPRKKNDDKKKGADAAAANATDAAAIDAATQAAVSVNETAAAANVTDAATVEAECVSAAMAAALNQTSAVDQATSDAIAAACGANVTDVQSAVANATATDAANATSTDTATADNSTSTDTSSNSNKSDGKTRKDKTSNKDTGNGNGNGGNNNLIDEIVSIIDGFVNKREAEAQAKKANVVRRRAARQYHERAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CBE6</accession>
    <name>A0A0D2CBE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016375804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CBE6"/>
    <dbReference type="GeneID" id="27328525"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01442"/>
    <dbReference type="HOGENOM" id="CLU_027655_0_0_1"/>
    <dbReference type="OrthoDB" id="2840209at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="665" mass="72394" checksum="04010273B671B3EA" modified="2015-04-29" version="1">MTPWARTEKTRASAITNSDETYAATGRQARILSKDAVVYYSTAAALFITPLIATIVWLSTNRNNWGNQHWSFIHSATIGGRLTQSGAKAIDLLCSAFIAPLVLAGFNFIWFSCARVATINEKDPSAQGVPLACLVELSTTTGGSYDILKLSTLLAPRTRRLLYLALLVIFSALAKSAFGNVIAYEAFNEDAAGQGTRLRMLSDAQLAVPNSFVSTTFAGVWGFSTQQRSSFANQFSGMMTGLSISNSSSLLTDKAYILNNVTTASISLPSTVRALHSVPASRWTVSCKPFAPDTFMVQQMGVKSVLFTMTRGQTDLLSGYYPGDIALMQNAYNDDYPFMAFPYNGSSAFLGYAGSFNLSNETYPSPYGDIIPKAFNMTASGFNGTKQIMSVWGIECQVQRQNGTVDLVRSAEGWDRNAASVKMSDGKTVYQPLRMQQLQLSLNYQAPDVTIPGLAPALARSADPCYDATITGTECAVSTSSDGTSETTSRTIDFETLALNFLYASAETERMAYEVASTNTSRDQPDFFVNVTDTSQILRYRITYVPVILFIGIGCMFVAAGITLALVAMSWKSISARSFRQVDSLRLLVDVLAGLRQDEFVSRPQFNTTLEGTSLQNDRDESKISKFEDLKASSGAELETWASACRVRYIEDNGAVGLERLPAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y499</accession>
    <name>A0A0D1Y499_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229997.1">
        <property type="nucleotide sequence ID" value="XM_016386189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y499"/>
    <dbReference type="GeneID" id="27338964"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11881"/>
    <dbReference type="HOGENOM" id="CLU_1372232_0_0_1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="206" mass="22625" checksum="E67182B77280A125" modified="2015-04-29" version="1">MPIPWERYLPGGFYHQQAALSPIEEVCESPFARPAAALRQNLNNNANNGWSNDTSYFPRPSVSHMAGFPGTYERHSGLRDSSGSVQTSSSVSLANERRDSQNLDSEKEAAKLANGAEEYEHDARGSGGAQRTGSAAHRSEAPNFSLPDRGLTRPFFPSRLGNNKVETIDTAYSVRDRRRGGTTMSAHWRNFSLPSNAVIRRSGIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y4D3</accession>
    <name>A0A0D1Y4D3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230032.1">
        <property type="nucleotide sequence ID" value="XM_016386224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y4D3"/>
    <dbReference type="STRING" id="91928.A0A0D1Y4D3"/>
    <dbReference type="GeneID" id="27339000"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11917"/>
    <dbReference type="HOGENOM" id="CLU_037891_0_1_1"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="83"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="374" mass="41225" checksum="03F41871DBBB69DD" modified="2015-04-29" version="1">MVRKKTFSIKAWPFTPEPSPRLEPAIYILDNISEGFDMSGEDMGRARPISMVSRREGIMSPGRPTLEEVLNNTAPPPYTLAAFTAFLSQQHCLETLEFTTEAKRYAEKYDEASGHLAGMPLTVDTQEGWDLIQDWNRMLDIYVRPGSPREINLPAEERDALVHQACEVTPPLPETLDAAVRRMFDLMSESIFIPFCNSLRHLPYAQTYNAMSEYASYADLEPSRLTFDERTMHHHASRRRRSPPNTSDASFHPSRSPPQQHNRTSTLSSALGRQSGNRLSTHVSHSSAVSESALTDSSGGPDSPPPGDLDSSITPPTTPPTSDLGIASISHGSSGASLYQTKTQRSESGSGWKKAMKLFSGAGKKKSGSFHEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y4D9</accession>
    <name>A0A0D1Y4D9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230037.1">
        <property type="nucleotide sequence ID" value="XM_016386229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y4D9"/>
    <dbReference type="STRING" id="91928.A0A0D1Y4D9"/>
    <dbReference type="GeneID" id="27339005"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11922"/>
    <dbReference type="HOGENOM" id="CLU_025711_4_3_1"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="234" mass="26077" checksum="12422643987F6F0D" modified="2015-04-29" version="1">MDRDKVLVFGATGPAGICVLRELLSRNIPALAFCRNPGKIPKDLSDHALLEILKGDMTNREDFSRAISKSRAIISLLGPSADRQPRNTFADYYRTIVSSMKEHGVHRFLVLGTTAIYRHDDRTSIVRSLMKALIQLVVNHAYQNVMAIQEYFDSVQDPSIEWTVYRLGWLTGTSDPAAWSEDRKKGEAYAGPVGGPGFTSGVNRSILAKWLVDTSLDPSAKWKQQMPAVSNLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y644</accession>
    <name>A0A0D1Y644_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230582.1">
        <property type="nucleotide sequence ID" value="XM_016385638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y644"/>
    <dbReference type="STRING" id="91928.A0A0D1Y644"/>
    <dbReference type="GeneID" id="27338411"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11328"/>
    <dbReference type="HOGENOM" id="CLU_026450_3_0_1"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="59148" checksum="E6A2ADBD83F5ABF9" modified="2015-04-29" version="1">MSSLSTSTDSPGSRPPSTSSSESDRHEYTAHPVSHHGPEFVDLVVPSVPNGGIESDAMAESSDHVIHLSSIEHCMPRSYIRICLAYKVADEGMLPQALSRLDRYIRKLVDAKPYLSGYVVSVPEPDKQVGAVEIRFSDQDFLEYPSVNVRHLSHEEVPYTYEELESKGLPPSIIKPELVSALSESADEERAPVFRVQANVVKGGLILSVYLHHCISDGTGIGMLISGSVLNDEFTFERYLDGNGHETPSLSRRLNAFAHHKSIVRQELSYNFANQINTRHLKCKVVKPRSEIKGGAKVQGRGCVMSIPLVGLQQLREGLQAICGSDFFSQNDALQALLWHAMTRARIPSLAEDDNVRESSLLIPVNIRNRLKKALSESYFGAAIDFASAKMPLSHLKGSSVAALAESAVTIRNAINDVNEPYIRQAIALARYVDPTIDVRDLQASNMDRAKGADMYVTSWEKLSCYEATFEMGLGPPDWVRKPWSKDPGSCIVLPRDERKDYLEVVIQMTQDDMARLLEDQEFMKYVSRVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y6Q5</accession>
    <name>A0A0D1Y6Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230757.1">
        <property type="nucleotide sequence ID" value="XM_016385813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y6Q5"/>
    <dbReference type="STRING" id="91928.A0A0D1Y6Q5"/>
    <dbReference type="GeneID" id="27338588"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11505"/>
    <dbReference type="HOGENOM" id="CLU_054409_0_0_1"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="238"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="421" mass="46865" checksum="77AFA03DE12ADF9C" modified="2015-04-29" version="1">MQCLAPQRPSFKALADILYRHRRHQFSTSQPRLQLKQVPFLSSWNQDVFEREAYLPATPARLPRSAEHIPPACSKWFIHDNDVDFVLTSSTTSPSTNNSTDVKTIHFPTSSELRTSFWSDYESAIVPLEITSKGNRHEGEEETFERIEAPLKVLLTYLSNPDSSISGSSTQLPPPSQENKHSIYLAQCDLTSLPSSVVDDIPTPTPLRIVSSSSSSSSSSKSRCNPDSISSGSSSTSSAFYSGEAGGNRPKKRRGMIKGDIYASSLWLGRPPTYTPLHRDPNPNLFIQLAGRKAVRLLPPEVGGAIFDDVQDRIRIASRTARHTPSSATIRGDEMMVGPEKVALHDAIWLDDDDDDYDNHVDSDTDDDKPKTKNRYSDVLRTYGLETHLQLGDALFIPKGWWHSVKGVGHGVTASVNWWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7W0</accession>
    <name>A0A0D1Y7W0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231212.1">
        <property type="nucleotide sequence ID" value="XM_016384610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7W0"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7W0"/>
    <dbReference type="GeneID" id="27337378"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10295"/>
    <dbReference type="HOGENOM" id="CLU_008511_3_1_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="175"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW10996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="584" mass="65822" checksum="6D1F79F24F79399C" modified="2015-04-29" version="1">MSSAASFLDSVRQAIEAQVSNEFRTDTAPVSARATQTRTRRLQYVLPPRKVSDELQENYWNFVYPLYPFVARKTFDQIYRSLWESAPLPDTHSHLMRLDESASMATLNLVLALGCQYCVQNEPGEAHEEAEVFFERAHALVPYDPTDTSVLSLQFVQVMLLMAQYLIGTGKSHKAWGIIGVALRACHHLGIHRIAISLRNPLNDQDREWVRRIYLGCVTLERIVCMNLGRPAMITVCNDCPTLLPLQTEDGNFNVISPSDPSAEPSVLAFFVVSTKLYDIAQQILLSFYSEEKPDVARGYHRYFEGNPSVLKLDRKLQEWCDDIPANLEFRSGTSIAQAQNDLAVTIRRQAIVLRLRYLQVRIYLFRPVFATLCVSQSAPTSENPSGRPCGEDLNYRVALQCCVLCVKAAKELIEIMHNNLTTTRSWGRKPAWLYGTLHVYLSATVLLAARFRPVVTLGAISDSELQLSWQMAMEILQSFQNDNISAQRCVFALRTLYGRLWLSADTHVVTGNENFQMQTRLPNNNLVGNGQVQSFQPTDGALSDQVALDGQEISQVFEWADLFDAFDPSDLSWLNVVPGDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y9J8</accession>
    <name>A0A0D1Y9J8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Swi5-dependent recombination DNA repair protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231877.1">
        <property type="nucleotide sequence ID" value="XM_016385275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y9J8"/>
    <dbReference type="STRING" id="91928.A0A0D1Y9J8"/>
    <dbReference type="GeneID" id="27338046"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10963"/>
    <dbReference type="HOGENOM" id="CLU_045012_1_0_1"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28527">
        <property type="entry name" value="MATING-TYPE SWITCHING PROTEIN SWI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28527:SF1">
        <property type="entry name" value="SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28177" checksum="4AF4C8D369A39F0D" modified="2015-04-29" version="1">MHPAKRRRLDQSAASLTKPFRSPLRKLSSNRSHKGELSSPETRLQEATNKSSPPVTLSHDADKTSASPVVSKSTNPDRQIHLCLDRRGHQKQHVALSLQLKKLSHSLELAQQVLHIETSQQDVQLRSLISKWKKVARDVAEQLFEEAKERIDEMGGFKAWQDRSREDARLWHDDQRTSYESRQLKVDDECSSESTTTGTERRRTAEISTEHDTDSSFFTMEKMLQVMNIDLKLIGYDRQSEGWID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YAN6</accession>
    <name>A0A0D1YAN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase small chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232197.1">
        <property type="nucleotide sequence ID" value="XM_016383574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YAN6"/>
    <dbReference type="STRING" id="91928.A0A0D1YAN6"/>
    <dbReference type="GeneID" id="27336338"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09255"/>
    <dbReference type="HOGENOM" id="CLU_035339_0_1_1"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="408" mass="46792" checksum="0E47E2C43D108AFF" modified="2015-04-29" version="1">MLYAQAASSLENLKVKDSPIKKLNFNVDDKENNPVVDATPVMTEKLDLAKVQEEAPKPAEQNRPKTLKELEAEEDLLKENPHRFVLFPIKYHEIWNHYKKAEASFWTAEEVDLSKDLHDWHNRLNDDERYFVSHVLAFFAASDGIVNENLLERFSNEVQIPEARCFYGFQIMIENIHSEMYSLLIDTYIKDPKQKTYLFDAIDTIPCIRKKADWALKWISDQNSSFAQRLVAFAAVEGIFFSGSFASIFWLKSKGLMPGLTFSNELISRDEGMHTDFACLLMQHLKHKPAPELIERVITEAVAIEKEFLTDALPVALLGMNAKLMQQYIEFVADRLLLALGNKRFYNAQNPFSFMENISLAGKTNFFEKRVGDYQKAGVMTSKKEEKSTSPGEEKGEDDGGLNFNEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YAW4</accession>
    <name>A0A0D1YAW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_09320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232262.1">
        <property type="nucleotide sequence ID" value="XM_016383639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YAW4"/>
    <dbReference type="STRING" id="91928.A0A0D1YAW4"/>
    <dbReference type="GeneID" id="27336403"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09320"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW12046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="56726" checksum="AB2A0FD8FBD724DF" modified="2015-04-29" version="1">MASPSYANVPVLFCLTVLGGVLSVAIYRLFFHPLAKVPGPRLAALSRLYDFYHDCILGGKFSFKIEELHDRYGPIVRIGPNEVHVRDPDFFDEFYNVTSRLDKDSWYYAFVASQDAGFGTANVDLHKARRKAMSRFFASSAISNLELSSREKVAKLCKRLNDMRDEGKPVNMSNAYRCLAADSVTDYCLPKGFNLLDSIDFADDYNKQSRTISYIAVWHRHIPIIIPLFMRVPKWFVEATSTEGGKMAFEFQADLARQAGDIVHSEKRSDKSVLDGIVNSDAIPESDKTVDRITQEARTLVGAGTETTGISLETITFHVLANPGVLAKLKQELAAAARSSAPGSEDPLTTYSVVHRLPYLTAVINEGLRLGNGVSGRLARVNPRHTYTYQSYVLPPGTVISMSIRDNHMSEDIFPDALTFNPDRWLVKGEEQKRLEKYFVPFGRGGRSCIGKELALMNLYLTIASFFHKFDAEIFETRRKDVEIEHDFFSPFPVAESKGLRVMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YBY9</accession>
    <name>A0A0D1YBY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232657.1">
        <property type="nucleotide sequence ID" value="XM_016384034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YBY9"/>
    <dbReference type="STRING" id="91928.A0A0D1YBY9"/>
    <dbReference type="GeneID" id="27336801"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09718"/>
    <dbReference type="HOGENOM" id="CLU_010194_13_3_1"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF31">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="306" mass="33946" checksum="B698761B717C5F09" modified="2015-04-29" version="1">MSAVYEYTGPVDCSVVPDKTQCKGKSVIVTGGANGMGEAYVREFVKNGAFVTYCDVNEERGKAIEAELSPEKTCFVKCDISSWDDQVRMFEAAVTKSPSKTVDIVISNAGVGRGAGDPMMALEDPLSKPTKPSMHIIDINLVGNMYTFKLAIHYFRRGDQTPDRDRCFIFIGSIAGICDNLGSWEYSTSKWGLRGLMRTARRNAPHQGIRVAYVAPAWIRTAIQTQETLDRLAKNGVEFATIESAVKCIMRISCDKSINGHSFVICSESVSQDGFIDAEEDDRTDENHWLQKIQRTVFRARGDAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YEC8</accession>
    <name>A0A0D1YEC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233652.1">
        <property type="nucleotide sequence ID" value="XM_016382949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YEC8"/>
    <dbReference type="STRING" id="91928.A0A0D1YEC8"/>
    <dbReference type="GeneID" id="27335707"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08624"/>
    <dbReference type="HOGENOM" id="CLU_072385_0_0_1"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="67"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="254" mass="27528" checksum="BE0A9F5961B6DDE5" modified="2015-04-29" version="1">MAKAIPQSADPTVRYLSTSQAYDLWSAVYDTDGNFLQALDTIEMKIFMPRLLGLLEASALSRPWKLVDLGCGTGRNTAALLEVKDANVFGLDVSPGMLEVARRRLENGGAKGRLSLEVFDMIEQDSASDSALNADAVVSTLVLEHVPVDVFFNHVAKILRPGGYLLLTNMHSEMGGISQAGFVDPDTGEKIRPTSYAHTIAEVEAEAAKKGFELIGNQIEQRAVDESLVSLLGARSAKWVGVTVWFGGIFQKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YFU5</accession>
    <name>A0A0D1YFU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucose/GDP-mannose dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234127.1">
        <property type="nucleotide sequence ID" value="XM_016381025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YFU5"/>
    <dbReference type="STRING" id="91928.A0A0D1YFU5"/>
    <dbReference type="GeneID" id="27333775"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06692"/>
    <dbReference type="HOGENOM" id="CLU_023810_0_1_1"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491:SF2">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="298"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW13911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="392" mass="43386" checksum="882071122C52450B" modified="2015-04-29" version="1">MTISYKTGKVAIVGVGYVGESLLREFSSVHPTIGFDISESRMKYLRSQYGEDKNITLTSDESMLEKAEHFLISVPTLMKPDHSVDMSFIKSALSTVFRHAKTGSTIVIESTVSVGTTRQLFSSVQHLFNCGMSPERVDPGRTFPAPHDIPKVISGLTPKALDIITTLYSSVYNHVVPVSTPEVAEMTKLFENCYRMINIAYVNEVSDACRTLGLNPNEVIDAAATKPYGFQVFRPGIGVGGHCIPVNPSYLLQSCPDLPILEHSTKLMRNRPAKLARELYEHCLSTKFALTDLRPRVLVIGVGFKPGQSVLSHSPGLDFATELNNLGCDRLAFYDPLVSGEAVPWMEKLEDDAFTPTDLVSEFDVIAICTRQHGVDFQLLDNLPENMVWSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YGR3</accession>
    <name>A0A0D1YGR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234397.1">
        <property type="nucleotide sequence ID" value="XM_016381295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YGR3"/>
    <dbReference type="STRING" id="91928.A0A0D1YGR3"/>
    <dbReference type="GeneID" id="27334045"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06962"/>
    <dbReference type="HOGENOM" id="CLU_012494_3_3_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF24">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="94"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="406" mass="45694" checksum="4DE16D5B3C35D735" modified="2015-04-29" version="1">MSSSHFGVTWRKALVSLPRLVPDFVLHWTSPEGPHPLVFDVPSRDSHKIPLYVFIPPDHNPRHHKPASEGTHLHEALHLPRGTGDEERSLPVLIDFHGGGFVLGSCQEQVPFCAKMCRELNCVVISVDYRLGPAAQYPAAHFDAEDVTRAVLDPTKPSYRVLRASIQSALQKQKRKNIQLDEQRIAFSGFSSGGNLALNMALTTKNDPTIHTDWPSPVPWDLKNHVPLLLFYPSFDTRLLPHQRPRPEGYDAPPTFAERWRLEAELMPTYLPASKSGHPRASPGLADLRAPEGDNSGLHPKAKIMLILPQFDTLHHQSVVWIKKVNDEGRGSDLNVVEVKGVIHGWTQFPDSWLDDDSRASKWEMFEKARMFLDMYWNHPEGKEVDVVQLATNDDGDVKVDSTPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YHY9</accession>
    <name>A0A0D1YHY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycoside hydrolase family 30 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234717.1">
        <property type="nucleotide sequence ID" value="XM_016381615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YHY9"/>
    <dbReference type="STRING" id="91928.A0A0D1YHY9"/>
    <dbReference type="GeneID" id="27334368"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07285"/>
    <dbReference type="HOGENOM" id="CLU_031530_1_0_1"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251957" description="Glycoside hydrolase family 30 protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="6">
        <location>
            <begin position="131"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="7">
        <location>
            <begin position="387"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="52770" checksum="F89E0C1B40DCAA55" modified="2015-04-29" version="1">MKSVTIVVVAATVAATATTCSAWSYTPSMTYSASISVNALQKYQTMIGGGCSGAFGIACQQFGSVGLSPSNQDLVTQILFDENIGGLSIVRNDIGSTPGIVAGDVSSILPDCPPTPEGPFNYVWDGNDTCQLQLTQTALKYNPNAYVYADAWSAPGCMKSVGTEDNGGFICGVRGASNCSADWRQAYADYLVQYVRYYEQEGIEVSLLGAYNEPDFNPVTYASMESDGYQAKDFLEVLYPTAKAAFPNISIACCDATGARQERNILYELDQAGGSEFFDVATWHNYQSNPERPFNSGGKPNLMTEWADGTGKWNSYWDVTGQLAEGFQWALYMHNAFVNSDTSGYTHWWCAQNTTGDNALVRLEYDAYYVSARLWAFASYFRFARPGSVRVEASSSAENLYVSAYVNANGTVAVPVINEAHFAYAVTIEVAGVTDVSVATAYLTDNNHNVTMAGQVEVDVVVGGGSGESGGVKFEATVEPRAMKTFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YL51</accession>
    <name>A0A0D1YL51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235992.1">
        <property type="nucleotide sequence ID" value="XM_016380165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YL51"/>
    <dbReference type="STRING" id="91928.A0A0D1YL51"/>
    <dbReference type="GeneID" id="27332909"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05826"/>
    <dbReference type="HOGENOM" id="CLU_360160_0_0_1"/>
    <dbReference type="OrthoDB" id="5426978at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="759" mass="83769" checksum="69517A7C9344FBB2" modified="2015-04-29" version="1">MARSIHGRDQSGDDPTSSFAGPTGSQFDASSFNFPIDTQLAAMNPNYGMSTYPRDLDDPTASLAHSGAEQLNTLAAASNGADASMAPPQTPNQASFMPARKSVDDLSDAMQTPQTGDKRKRSKTSRACDECRRKKVRCDAPTEADGTPKTCSNCQKAGATCEFERKPMKRGPSKGYIKELAERVQQVETVQKQAQALRQSVDGSSNFTTYAEAFSPDDANPRRQFSFPDTRSPFTPSDFQRDRIPSTGAWGNIAPSLRSRDTGSLMIAPDQSMPGNLSNQEAVRMAESVKPFWSEVDSPPPQKRPRLDDAYAKLEKFDLSEDYFNRYYTYVHPRFALLPEVDSVMKVVSKAVPAIQHAFTLSIELLVSSQNDSAVNGNQSDEISVASHRRSLPTTAFEDIQELTTYVVSVEQDAASNTVPDNVTCLWTLLLLAAACDSDVNQIAGPNATKNDLLASSLRVIHLFKSKDTQLVADEMGAEQIDGIVRQAFSCQCLMSKLYDLSSGSYARTLSPQETQAKETMVGPADTAKMPAEAAFLMQSSNIITMVTCLLHLDASSFAGAQVKRILTFGLFENTLKSSPTLSLDSPVVRQVKLLLELLTARYPDTDFSPMIVLMKATQLTECLTTDSPAYPNFSPLDMHCWSLATITFCELAMHAKSDMYIKPALENMQILKSALQQKSELFRKQYGYAFFWSPEKSVADGYRMSHWTDCLLNMIDDVTARSSTLGEGANDDTLVLPNFSLLLVQGWFRALYHYRWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMG5</accession>
    <name>A0A0D1YMG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_06277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236442.1">
        <property type="nucleotide sequence ID" value="XM_016380615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMG5"/>
    <dbReference type="STRING" id="91928.A0A0D1YMG5"/>
    <dbReference type="GeneID" id="27333360"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06277"/>
    <dbReference type="HOGENOM" id="CLU_103863_1_0_1"/>
    <dbReference type="OrthoDB" id="4135672at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="139" mass="15620" checksum="39F951A9F1915DB1" modified="2015-04-29" version="1">MANSKPDQAPFYDVYWVESAGMPRNHVAIFVETHELGPGTGHNFQVSGTIQLGMYHNHRPGKKPEEDEQSAFVSKRLLGRVPRAVYDDGTFRQVCDRVEPPPKQFEGAKRLFPGRRLIRCGEWAEDAVGQLKSEGILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMK2</accession>
    <name>A0A0D1YMK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_06322</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236487.1">
        <property type="nucleotide sequence ID" value="XM_016380660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMK2"/>
    <dbReference type="STRING" id="91928.A0A0D1YMK2"/>
    <dbReference type="GeneID" id="27333405"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06322"/>
    <dbReference type="HOGENOM" id="CLU_002848_0_0_1"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="14">
        <location>
            <begin position="183"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="439"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="685"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="993"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW16271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117882" checksum="9CD70B82523905A6" modified="2015-04-29" version="1">MTSTPASSAKETKLSLQTLDQLMQSLSVSKTQDEINAASNNLATLLNGPIEEQVMPTKAVETFKKQLGNKKDAAVRERAIDGIKAIAAHSTISPAVETYLISLLPLTLAAVGDKMVSVKNAAQAASLAIVRAINPNAVKAALPHIRNSIITAQKWPEKMNGLDCIEALVETAPTQLSFLVPTLIPIVSESMWDTKPEVKKKAYGTMEKICKLIENKDIEKFIPELIKCIAKPENVPETVHLLGATTFVTDVHEPTLAIMVPLLERGLAERETAIKRKAAVIVDNMCKLVEDPQIVAAFLPKLMPALIKNYENMADPEAREKTKQGLDTLKRVGAVKEDGSFPKVSTAGEVATVVEVLKSILEPKHKDALKSEAVIQYVAAIAGQLIDEKVTDAPDWVSNTQEYLKTLVGEQDAPAVADQLRKKASPGIEEEAEAEPDEEEGEDLCNCTFNLAYGAKILLNQTHLRLKRGQRYGLLGPNGSGKSTLMRAINNEQVEGFPKKSEVKTVFVEHDLDAADTELTVIGWTMMKLKQVNIDKPQADIEAKLEEFGFLKSQFEGAITSLSGGWKMKLALARAVFEEPDILLLDEPTNHLDVKNVAWLEQYLINSPCTSIIVSHDSKFLNNVIQHVIHYERFKLRRYRGNLTEFAKRVPSARSYFELGASEMEFKFPEPGFLEGVKTKAKAIVRVNKMSFQYPGTDKPQISDITFQVSLGSRIAVIGPNGAGKSTLVNVLTGELIPTTGEVYQHENIRIAYIKQHAFAHIDNHLDKTPSEYIQWRFQTGEDRETMDRANKIVTEDDEKAMDKIYKIEGTQRRVIGIHARRKFKNSYEYECSFALGENVGMKNEKWTPMMTADNAWIPRSEILASHQKMVAEVDQKEALASGQFRPLIRREIEQHGANFGLDAELISHSRMRGLSGGQRVKVVLAACTWQRPHLIVLDEPTNYLDRDSLGALSKALKTFEGGVVIISHNAEFTESLTNEVWSVVNGKMTPSGHNWVTGQGSGPRLTDKGDDEEDKFDAMGNKIEGNKKAKKLTSSELRKKKKERMARRKRGEEVFSDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNH0</accession>
    <name>A0A0D1YNH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL23 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03819</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236847.1">
        <property type="nucleotide sequence ID" value="XM_016378170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNH0"/>
    <dbReference type="STRING" id="91928.A0A0D1YNH0"/>
    <dbReference type="GeneID" id="27330902"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03819"/>
    <dbReference type="HOGENOM" id="CLU_037562_0_1_1"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="7">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="156" mass="17306" checksum="7E9C3E13E460148B" modified="2015-04-29" version="1">MAPPTQKPSGSKSKKPSAKANQAAKATLKGVHANKARKIRKSTSFHRPKTLVLSRSPKYPRKSIPHETRLDHHKVLVHPLNTESAMKKIEENNTLVFIVDVKANKQQIKDALKKLYDVDTVKINTLIRPDGTKKAFARLTSDVDALDIAATKLSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQ93</accession>
    <name>A0A0D1YQ93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237622.1">
        <property type="nucleotide sequence ID" value="XM_016378945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YQ93"/>
    <dbReference type="STRING" id="91928.A0A0D1YQ93"/>
    <dbReference type="GeneID" id="27331683"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04600"/>
    <dbReference type="HOGENOM" id="CLU_008201_1_0_1"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04399">
        <property type="entry name" value="RhoGAP_fRGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000044">
        <property type="entry name" value="Rho-gtpase-activating protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000050">
        <property type="entry name" value="RhoGAP and Fes/CIP4 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000073">
        <property type="entry name" value="RhoGAP and Fes/CIP4 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="15"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="242"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="480"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="691"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="693"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="784"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="102089" checksum="97C800C05B715F59" modified="2015-04-29" version="1">MATESAPAPGRPKAPGFADSFWSSDYAGGLGVLFQKLQQGVIENNQILTIASMRAEAEEFYSDRLGDIAPSVDRMTGGFARDDGASVRKAFEGVRSEMVEATKNHKKIADNIRELVVNPFSRWCDAHATRIANSQEDLQSKIKAHDRQADLVKKLRSQYFNKCRLVEDLEEENKLAFQDRATGSPKPQSPPPPKIVLPEDELDEIPVEIGDETYSPDRLKTLLTDMLEKIPLGEFKVPILGVYQNVSAGTDIVDYIQKHMKASSVGYAEKIGQDLVDRGFLRLIGNMGNTFANSSRMKYQWKTRVFQITGVPEKKKPLGRSITGSSQDGILESPTIGNITEAIQGWNPLNNPHPNETPAERLKREAKEADEKYKAAVRKLDLLRCNLEESMMDHLKFLERCETDRLRAIKSVILDFSGAISNSIPSFQSQVDHMMLYQETIQPLGDLRYLLENYRTGAFVPKVVPYENYYGSVEDQTFGVDLEARARADRKRVPIIVTSILTFLDSHYPDLEGDEARRNVWLVDVPLAATHHLRNQINNGAPVPREILEKYEVPIVASVLKLYLLELPDSLVSSQVYDIIKTIYATTSDAAPNPISTDAVDSAPRIKVLQSTLGQLRLNNIATLDALATHFTRLIDLTSADEAYVTALAQSLAPCILRPRTESSLTLEERHAYRLIRDLFDHKEAIFGELKRQSSTSMSTRQRVVSTNDERSRRANMEERARAITEQRQRDKSPGPANRHRRDKSTDGSLGRFPVVASPRPDHGRSVSGIGLPSKRASLEVPGSNESSPVQARTQNQSAVDRNSVSIAQPNAGINGQGRKPEEASPDILNLPSTFSGGGPGPHIPPPLDDDSQDSDSGPQPTPKDADGGSRVGSLKRTAGGSGRKPVGGGGSLSRRSYQAYEGHPGQNQSQGVQLTDRPMDDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQE9</accession>
    <name>A0A0D1YQE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_04650</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237672.1">
        <property type="nucleotide sequence ID" value="XM_016378995.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1YQE9"/>
    <dbReference type="GeneID" id="27331733"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04650"/>
    <dbReference type="HOGENOM" id="CLU_002125_3_0_1"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF2">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="354"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="617"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="832"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="428"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="864"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1174"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1335"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1177"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1188"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1209"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1221"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1265"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1302"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1335"/>
            <end position="1349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW17456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1355" mass="151690" checksum="0D525562E4D12423" modified="2015-04-29" version="1">MASNDEFEPDSRQRNYRAPYTSRHPIPTVQKYKAERSELKSQQDEAESAQHDEEDDSKVKRAYHAAKGVITGDEPPKSMHDPYKTENRNLQGAGSHTEPRQRPEDSGDEDVEEQQQERPPSQDTKSGTHSKRDGKPDNEGKSATEAVAGEIDPRKKRKAMKHQDRNDGGREVTDPVTHLPIVIRDSTRKDLKRADENLPAVGERPETQTGVAGASKSSETLDREKDEIQKKHNGMQKLFPPPSFDDLKSELIKTYRIALAAGLGSIVLLVSFSMVAVHLFGMDFSRHDSRRHSSSFFMFIPPTTIFLASVGIGGVVVWAVQGWLGKKVEEVWKDEVWDAARSEELEATDSNDIVPESVSWLNNLLAAVWPLINPDLFTSISDMLEDVMQASLPKVVRMVSVDDLGQGSEAFRILGINWLPTGAASQSVASDGKLKSPNSEGKSDRSAPGGGQIEDGDDASDDNGNVDEENSHNKKQDETEQQAIREGMEAEQGDFVNMELAFAYRARSSGKSLKAKAKNAHLYLKFYLPGGIAVPVWVELRGIIGTMRLRLQLTPDPPFFSLCTLSFMGQPQADLSCVPLSRHALNLMDVPLISSFVQSSIDAALAEYVAPKSLTLDLKDMLVGDDFKKDTITRGVVMIFIKSAKGFKEGDGGIGPFEGSSDSYVTVSWGKFGKPVASTRIIVDDQEPAWHEWSHILVTPEEVNADEKLRLQLWDSDKYTADDDLGRVEVDLKELMHSTKFKNKMCDREDRFVGEDPDEKMPGTLQWKVGYFSKIKITEEQLKKQTAEPDIKTEADLRAKASEEAQRKLREATAKDESKEIKQQTLEDYKDHEDQLMISSPPPDDYPSGVFSIQIHNITGLEVQKLQKKDKKKNEGDREDEAEHSEDMPSSYATIILNHQKIYRTRTKPKNAKPFFNAGTERFVANWKTAEVMISVRDDRERENDALLGMIYLPLRRVFEKRSQVMQTYPLVGGIGYGRARISMVWRSVDLHLPKELMGWNYGTLEVKCPVRSKGGGDDNSYTQHRIKLRTNLMRAKMLPAGDGGKGVWKPKRDKQSVFLAVRKRYSSALVVEFRKSVLGPDTTSQFAVFWLKDIPDEEEVTVSVKVWKGGKKAIHRATTSYGYEGQDHEEPLGEIELTLKMWRGLSGYHKSYANRASNTDIKDVMEVLDTANDEGQVPDDEDGEGDSSGSSSDPDSGSDSTESGGGGRDTESDRDEGRRQRQQRRRGRNKKLRTHANDDSSDADSDAGKTSNSKLDPTHLASKPLEKVKDVAEKVFDVDGHNDQDDGSRGARAQVRDYKDHHRQMHRKHRGVMQWKGARTLDWMAGKVKRGKGRIGEVFEHNDDDKSGGVETEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YU61</accession>
    <name>A0A0D1YU61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239017.1">
        <property type="nucleotide sequence ID" value="XM_016377447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YU61"/>
    <dbReference type="STRING" id="91928.A0A0D1YU61"/>
    <dbReference type="GeneID" id="27330173"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03090"/>
    <dbReference type="HOGENOM" id="CLU_053381_1_2_1"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237210" description="Phytocyanin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="28605" checksum="71EDDF4F28230EAD" modified="2015-04-29" version="1">MSLKSLLFSTLLATGAVATYGGGYQGQSTWGLSSGAAPSCPAGCQPITPPAGGGGELIVQVVSVADANGSLKYFPNNIEAPVGSIVQFQFHPKNHTVTESSFAEPCKPIASNLTSVMRPGLRSGFVPVKGNETFTPVFNVLVNDTKPIWIFCGQTNHCQKGMAMVINQNSSGPNTIEKYIENAAKLPLTPTPNATVSTSSVVAAPPPPPATESANTVTFGATPPEVTAPAPPPPATTAAAETIATPPSSSVPAAPAVFTGAAVRAREASAGLVVLGALVAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUM0</accession>
    <name>A0A0D1YUM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239162.1">
        <property type="nucleotide sequence ID" value="XM_016377592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUM0"/>
    <dbReference type="STRING" id="91928.A0A0D1YUM0"/>
    <dbReference type="GeneID" id="27330318"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03235"/>
    <dbReference type="HOGENOM" id="CLU_013987_1_1_1"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="649" mass="73712" checksum="9ACC5AE927C3E91D" modified="2015-04-29" version="1">MPVQRPRETCTECSMRRQKCDRQIPCSRCVKRGIADKCTRQWPTQYDPSIHRVYKRSRPVASEGSGGSAPSSPAHQANTAPTAGSRLPQGLSDFAAYDTRWADEPRLQYNFTPTDALISRLRTRDPNTLPDKSWIDLNGIGFNSTEHAHSKFLQMLLPNVGHIWDLVNYHELCLLWYHGCYFGPLFRWELESVLADQDQKETLIVDGLDLQWLGLLFSIIAGSLTCAPERRLSQWGFQKAERSKLPMQWYKASISCLNQANYTSNHSIYAVHTIATLTMSAHSLGQSAELSVLLGGALKIAQSLGLDRLDYDASLDEITTTSTEEQRHRLIKREIGRRLWSQLCVQDWMSLPFNESYHIQPGHFTTTKPSNRNYLNMDPIPIEFPTYISYGNYLFEIAKLMVKHHEDISHATTQFTTYEHVLEYDSRMRTLATKGMPTYFHVVQPIDPAWPEWIPAARRSLTICFAHKMIMIHRAYIKQSFINPTYSMTRLTCLAAAKTILNEAKQTKDLDGPIIWVDKAFCIVAAIVLCLDLFHRPASDPVFDTHKELVSECIEYLRKFGGGVIAVRGANLLAALLTERNRVTSTWARHPEAIDMREILALVGAEMDGAVSPDDTHPRLLAELLPPQAGFCNRFIFENLFSFKNNTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUV3</accession>
    <name>A0A0D1YUV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_03321</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239247.1">
        <property type="nucleotide sequence ID" value="XM_016377677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUV3"/>
    <dbReference type="GeneID" id="27330404"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03321"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="532" mass="59742" checksum="8B1B36301EC11E7B" modified="2015-04-29" version="1">MVAATVSANPLKLDVRSHWKCIAICFVATLSTFQYGLDYALVGGFLSMPGFLEVFGYYDEELKKWNIDYTVQQLISSLMTVGTFLSSLLVGPFSAKFGRRHGLWAAAVLNYIATAIQLGTTSKAALYVSRLILGVSVGWFLTFAQLYVHEAAPAHLRGITFAVYQVMLSIGSIVGACVDYGTHTKLNRHAYQIPLAMFFIAPTLQSVLLFFFAPESPRWLFTQRKEEEAERSLRRLRNSHIDELEFKAELNEIRQSTRAQLEQNKKGAFLEMWRGTNLRRTLLSIAVVCFHSANGSSWVNIYTTYFLQIAGVEKPFSYSVLVTCTGLIGVLVSFFFVRLIDRRTVMLVGITACAICQLVPAIVWTKSPGTEATGRVVVAFIALFTFFYVAYAPYAWLLGGEYVNNQLRAFTFGLATALNFLGNWAGTFSAPYFINPAKFGWGPKYGYIWFASNIVCVIFTWFFLPETKDRTLEEIHEMFEARLPARKFKGYVCTGVESYAAEAMGDDLAERKGIHVHSTHVEMSDTTPDKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWP8</accession>
    <name>A0A0D1YWP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239947.1">
        <property type="nucleotide sequence ID" value="XM_016374671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWP8"/>
    <dbReference type="STRING" id="91928.A0A0D1YWP8"/>
    <dbReference type="GeneID" id="27327388"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00305"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="25654" checksum="97221C62EF1957C7" modified="2015-04-29" version="1">MSDFKGKVVAITGAGSGQGRVLAQLLAQRGALVSLADVNEAGLAETMQSLENSESHLSTVVDVRKSASVESWIAKTIEKFGKLDGAANWAGVIRINPVVEETDENWNFVMDVNSTGVFNCIRAQLRVMKDGASIVSAASTEGQIGWPTFAAYCASKHAVIGLTRSAAKEHVGIRINCVAPGCTDTPMMANDTVENSDEIRAQVQKRKANPMEIMRVAAFLLSDEASFVTGAVYNVDGGWVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YY63</accession>
    <name>A0A0D1YY63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240442.1">
        <property type="nucleotide sequence ID" value="XM_016375166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YY63"/>
    <dbReference type="STRING" id="91928.A0A0D1YY63"/>
    <dbReference type="GeneID" id="27327884"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00801"/>
    <dbReference type="HOGENOM" id="CLU_052358_2_0_1"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="306" mass="34127" checksum="3E7DAFAB100DEBC8" modified="2015-04-29" version="1">MSTPSAAPESSSYTAMDRDVEAIGKHCEFAYCHQLDFLPFRCESCHHTFCLDHRTETAHKCTHAGEWAKNRRRNSVGRAAAASTPGAGRPNHSNAAQCSNSTCKTFINTLQNTGVHCPHCNRSYCLRHRMREDHDCKNLIPLGARPLDIAVQSNKEKIKLGFGRLKTWSKNQQEMLVPKPKPSSRAAQLADLNKLKKNAKGDDKLDAEKRVYLHVEAEAASTTSKLPRADLFFSQDWSIGRLLDDAAKRLQVANVNNRVETEEQRLRVYHVEGGRLLEFSEKVGKSLINGNTVVLLRGVGPKEAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z9W9</accession>
    <name>A0A0D1Z9W9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230028.1">
        <property type="nucleotide sequence ID" value="XM_016386220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z9W9"/>
    <dbReference type="STRING" id="91928.A0A0D1Z9W9"/>
    <dbReference type="GeneID" id="27338996"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11913"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="25959" checksum="C79A8D2BC823CDC6" modified="2015-04-29" version="1">MSPTVVLITGANQGLGFECVKKLAAEQPDYHILLGSRNAQRGTDAAAKVTDLAPGSKVEPIQLDVTDDESIAKAAKYVEQKFGRLDVLFNNAGISKSPGKSFRDEMNEIYNTNTTSAACVTEAFLPLLKKAPVPRLVFMSSGLASAANTLDTALPFYGWIFKAYSASKAAMNNLGLSYAVLHGKEGFKVNMIDPGYRSTNINGFSETGGRAEEGALQACKIIVDTDKDGPHATFTSIEGTVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZDN6</accession>
    <name>A0A0D1ZDN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="4">U1 snRNP C</shortName>
            <shortName evidence="4">U1-C</shortName>
            <shortName evidence="4">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016384716.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:mRNA 5'-splice site recognition"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-C C2H2-type zinc finger" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="179" mass="18128" checksum="8B94DB67965ECBE5" modified="2015-04-29" version="1">MSVRKAHNSGRNHLRNVTDYYQQIGHEKAQSVIDSITASYTAEGQVNPMLQQAGAGFPPPPPGFPGMPPPPFGMPGAPAPGPGGIIPPPVGRGMPFPPFPPNGPPPPNLPAGLPFPPPGGFPPNFQIPPPGAPPGNFPPPPQQSIPGNPSPSNASGPPGQAPPPGYGMGAPPGMGDSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZEZ2</accession>
    <name>A0A0D1ZEZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L18-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_10808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
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    <dbReference type="GeneID" id="27337891"/>
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    <dbReference type="OrthoDB" id="6353017at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="2"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW11507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="189" mass="21377" checksum="1501023AC9881E38" modified="2015-04-29" version="1">MGIDLDRHHVKGSHRKAPKSDNVYLKLLVKLYRFLARRTDANFNKVVLKRLFMSRINRPPMSISRIASKVSTESAQKAYKDKTIAVVGTVTDDDRLLTVPELHIAALRFTATARARIEKAGGECLTLDQLALRHPTGSNVVLLRGPKNAREAVKHFGFGPHKHKKPYVESKGRKFEKARGRRRSKGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHJ7</accession>
    <name>A0A0D1ZHJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-Methylcytosine G/T mismatch-specific DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232608.1">
        <property type="nucleotide sequence ID" value="XM_016383985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHJ7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZHJ7"/>
    <dbReference type="GeneID" id="27336752"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09669"/>
    <dbReference type="HOGENOM" id="CLU_008691_0_0_1"/>
    <dbReference type="OrthoDB" id="5373744at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF5">
        <property type="entry name" value="5-METHYLCYTOSINE G_T MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="664"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="797"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="847"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="885" mass="96564" checksum="CAE14341597E3BCC" modified="2015-04-29" version="1">MPSRIRDDSPERRREKKEYSKLEKDRDRRDKDRDRDKDRHRSHRKIATKEKTSSRTSLSPVDDKRRPSMPGIVEETPLKSESKSSLPYPSFSKEHSREAVGSAARPVLNILTPPSTDLNASKDKLSTTKQSPDAPPSPPLTDKNAGSGRWKSSAGKPVSVQTIPEEERSSNGGKDAKIKIRLRPQSSRSNGHLRSTSELGTDSSPTRKHRDAIEKTHKPSTPLRNNVPQRSVSQPTRTESPSTPTTTATESVANTSSDATSIAPEQPTIQRPGSKVPPATVYAHAQTPGSIHPQSRGVTPLEVFMEREPSLLSETPGGVSATPGPPPPPPPPAPVAIPKVDYLLQHGGLHHAVPKNLLLAGKPMAIQQAQSPGQAPIVIANLFEPYTALLDDFDKVMSMNGSLAVATGYRSVARRLLDRLEAVFSRDISSEACQCPMCEYDHSEDVRGVSWGEVLELVSGRRDLPAWPPFAFTQSPIGLGISLEFHVPMQKLDIDVPEEYREHYIRQSRKTKQSVDKWLTRQTDNPSSPPEEVDEETLTFAILTHLPAEQRPVFKDLLGIVDRPIEAPRRIPTPELQTSNGSMKPPPPTPTPAPVPKIRPAHIAIASQAIQRLYRLHAVPRDSETALFMLNNPTLHNALATLAAISNDEWEILVSGRFDGFLRSGAEDAPPPLHDSGPSSRGPTPHLPPTRGATPGYTGTANGSGGTNGYRSRQGSYTQPYPAGTAQYGAPIAFDEETELATLAEIERDIYAGMEALEDAFEALHNKAECVRRALRERSAGLAAAQQRRRGALGGSGIEVRMDTPANLSDSGGGTGRWDAETDDGLGEWEGMSEIAPDDSASNISSARRRRPKRRNERRTPALIEEEDEDFDGAGSDATGSPRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZI57</accession>
    <name>A0A0D1ZI57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232768.1">
        <property type="nucleotide sequence ID" value="XM_016384145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZI57"/>
    <dbReference type="STRING" id="91928.A0A0D1ZI57"/>
    <dbReference type="GeneID" id="27336912"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09829"/>
    <dbReference type="HOGENOM" id="CLU_012062_34_5_1"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="100"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="304" mass="34806" checksum="A6904415995E1557" modified="2015-04-29" version="1">MADVSSTRLYLGNLPRNITKQDIEDHFGTHGAGSIKEIKLMNGFGFIEYEDAMDARDVVPDGTEFKGERLTVQFARGPRRKDDFSGPPDRNIPRPRRTIYRMQITGLQPDTSWQDLKDFARSSGQLDVVYSETGRERDGKGFVEFETQADLKTAVEKLDGQTFKGAVVHCTADVQDERPDPRSYRQRSPPRGRYPMDDYYDRRGPPPRGWSPRGYRERSPGRRPPVDDFYDRGYGRRTPPRDYPPPRRYDLDPYDAPRGPPPPPPARGYGDPYARNGDPYPPRPRSPRGYGYGGGYGGYDDRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIX2</accession>
    <name>A0A0D1ZIX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_08004</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233033.1">
        <property type="nucleotide sequence ID" value="XM_016382330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIX2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZIX2"/>
    <dbReference type="GeneID" id="27335087"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08004"/>
    <dbReference type="HOGENOM" id="CLU_032784_4_2_1"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="179"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW12817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="415" mass="46312" checksum="21C0026AAC503356" modified="2015-04-29" version="1">MPEKQRVCLAYSGGLDTSCILAWLIEKGFEVVCFLANIGQEEDFDAAREKALKIGAKAFYCVDVVDEFVKELCFPAIQCNASYENVYLLGTSLARPVIARAQVDVAQKEGCQWISHGCTGKGNDQVRFELAFYALQPKIQVIAPWRIPEFYERFKGRNDLLEYAAQQGIPVSQSKAKPWSMDENLAHCSYEAGILEDPNTAPPQDLWKLTADPITAAPNEPEDVVIEFEKGLPVSIDSPSTGKKTSPTELFLAANALARKHGVGRIDIVENRFIGLKSRGCYETPGLTILRNAHIDLEGLTLDREVRALRDQFVTIGWSRVLYNGLYFSPEREFLEASIKESQKSVNGQVRLKLYKGNCIIVGRSSETEKLYDASESSMDEIGDFEPSETGGFIKVQAIRLKKYGQMKAEKGERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZKD5</accession>
    <name>A0A0D1ZKD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylalanine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233513.1">
        <property type="nucleotide sequence ID" value="XM_016382810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZKD5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZKD5"/>
    <dbReference type="GeneID" id="27335568"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08485"/>
    <dbReference type="HOGENOM" id="CLU_014801_3_1_1"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="741" mass="82289" checksum="6B6166548A503E40" modified="2015-04-29" version="1">MASRSDHPPLDIAMDTDPSLGQSVAYELSHMPHLSMTFRAWQKLKSCYGRPIEINGYNLDIASLVAVAKEGELPYLEQSAELFQRLDESQRILQENLVAGNQIYGVNTGFGGNADLRTHNLIDLQRALTQHQHSGILIMDDPELQPYVDRELNPHSMPSSWVRGSMLVRCNTNLRGHSAVSLKTIDTMMEFIRRDFIPIVPLRGSISASGDLMPLSYIAGALQGNPDILLRCGGDEVTIMNSQEAFAKLRRLHLEEGNGSYAYHYSPLILEPKEGLGLVNGTAPSATVASLAMWQANQLAVLSQVISCLTSEALGANAEWTHPFIAKVRPHSGQTEVARNMRKLFEGSKLVRGLGDHINREQEGLVQDRYATRTSPQWIGPQLEDLVLATQQLVCELNSTTDNPIIDSETREVRCGGNFQATSVTMAMEKTRLCLQMIGKMLFAQTTELLNPTLNNGLPPNLTPDDPSLSYCLKGVDINMAAYQSELEFLTNSVSSHVQTAEMNNQAINSLALISARYTMDSVELVSLMTASAIFVGLQGVDLKVMHKHRLDLDESYVKDITFECFGETAILSEEALEELHPIMWRKASEAWYASAKSDASDRASAMAAAAVEAVMGYMMTHELNSTPSARQLLQETNIFQERLHESMLTSFVKYRTEFTKSPRTVGYLGRGAAALYQYVREDLGVPFYREFQEDPQDGHIVGRTEKTVGSYLSRIYHTVRHGTLFDALMKSLEGLVDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPL5</accession>
    <name>A0A0D1ZPL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234978.1">
        <property type="nucleotide sequence ID" value="XM_016381876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPL5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZPL5"/>
    <dbReference type="GeneID" id="27334630"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07547"/>
    <dbReference type="HOGENOM" id="CLU_007526_0_2_1"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="371" mass="41353" checksum="F839AFC80363C9DE" modified="2015-04-29" version="1">MAGPVRQPIDLAALERYVDKNVPEIKTPLDLKQFGFGQSNPTYQITDSTGTKYVMRKKPPGRLLSKTAHRVDREYRIINALGQTDVPVPKAYCLCEDESVIGTAFYIMEFLDGRMITENHIPGSSPEERYEMWRDAVRTLAKFHRVDFKTIGLSDFGRHGGFYDRQLKTFGTLSKAQAATEDVDTKKPVGDIPHFTDMVDFFKQKSSQPKDRSTLIHGDYKIDNLVFHKTEPRVIGILDWEMATIGHPLSDFVNLTAPFSWVGRVNGSGQSEKSNEAFKPGATPGLPTLDECIKWYAEASGYDPASELAWGTAFGGFRGAIIMQGIAARYARRQASGTTAKNYAEQMAPYGEWAYGLVEKLIATSDGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQ36</accession>
    <name>A0A0D1ZQ36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_07697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235128.1">
        <property type="nucleotide sequence ID" value="XM_016382026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQ36"/>
    <dbReference type="STRING" id="91928.A0A0D1ZQ36"/>
    <dbReference type="GeneID" id="27334780"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07697"/>
    <dbReference type="HOGENOM" id="CLU_042321_0_0_1"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="102"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW14912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="405" mass="45972" checksum="BA25AFB4AFD47055" modified="2015-04-29" version="1">MPGLAFGLNAGKSQPGISKPQKRKAFFDEEDDASEQKPPPQYGAKKTSKPLRPLSAFDDDDDDDSSSPAKEEPKQYGLQPAKGKSAASTEKYTNLSALRSAKLHDEEASKIDASVYDYDGAYETFHAKKEKKSSAGEQESGPKYMTSLLQSAEVRKRDQLRAKEKALLREREAEGDEFADKEKFVTGAYKKQQEETRRLEEEEKKREEAEEERRRKGGGMTAFHKQMLQKDEERMRTIKEAEEEAAKKKAAGVEDEGETEEEVTDSKLAEELNKQGARIVVNDEGEIVDKRQLLSAGLNAAPKKPGREAEAPKKVNDGRPQEYWRSSKAQDARQGQRERQSRMMERQIEEMAAKQKEAETEEEKAQQEKNKSRVTEADKMGAKERYLQRKKEREEEARKKKEASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZRZ5</accession>
    <name>A0A0D1ZRZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235753.1">
        <property type="nucleotide sequence ID" value="XM_016379926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZRZ5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZRZ5"/>
    <dbReference type="GeneID" id="27332668"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05585"/>
    <dbReference type="HOGENOM" id="CLU_399006_0_0_1"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="478"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="680" mass="75200" checksum="3CB77763A156EDC6" modified="2015-04-29" version="1">MTFSSVVKKPGQKKVTPKTAPRRNVQRSRPTAPPSLTPDSLTSSPAVEVAEDDTTSQNTEPVQAQTVLESTEIPSIVESVETSLPLSNPLETSNRERITEPSNVTANTPLSVPVEITAPGSTSTGVTIIHPVHETTWESRSNTIPTIAASTAPVRSTRKSTGAPTPSAASVETARQDEDLTDTGCQSPTDSRKRRKITHTVHELVESRAQTTPPPSDDIPLLLRASPQRRRSESRTSEVLLQDATSQLAAISELANSIEQRARSLRPRSMRLSYSETEDVGEGDTEAQAGSPEETSLESMAKKRSQRKQSRAKRIRELAEQVVENAVDGTPKTRRKARLPTPENADELQIDPEEVSMGDLTRDNKVGRKSETEKRMQENWTDIQKRRKEDVERRREAAGKGRAGRQELFQDALVEPIQVPKQIIVNGQIIVANESREVAFGAGVEQAADNDQEVALEDDRIYRYVNQGTLGKRAGLNRRTKWDDESTELFYKGLRMFGTDFAMIANLFPSFDRRQIKSKFVIEERLNPVRVKDSVDAKEAVNLEEYAKMSDQQFEDPAKLMEELAAEEKRLREEDKRRREGDGYVLEGADVPLPSTETDFEQGDNTLEGDGTVTAAGVHRERISTLADSAAAGSAVPKKKQAPQHRATKEPVGRGRQAKKGRRPTEGVEEALGPIDEVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZU00</accession>
    <name>A0A0D1ZU00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="2">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="2"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236493.1">
        <property type="nucleotide sequence ID" value="XM_016380666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZU00"/>
    <dbReference type="STRING" id="91928.A0A0D1ZU00"/>
    <dbReference type="GeneID" id="27333411"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06328"/>
    <dbReference type="HOGENOM" id="CLU_018822_0_1_1"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000021">
        <property type="entry name" value="Acetyl-CoA carboxylase carboxyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF46">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="6">
        <location>
            <begin position="28"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="7">
        <location>
            <begin position="283"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="540" mass="58694" checksum="C0A1EC6753C3900F" modified="2015-04-29" version="1">MAQGAGFAVAESLVDLNQEAYRSNRAAWEPVLKEFTTNLKKTVSEGTAQSTSRHESRGQLLARDRISLLLDAESPFLELGSFAGFDLEESSPCASLLAGIGSIRGRICMVIAHIATQKGGAWNELLVIKQNRVTEIASENDLPLVALVQSAGVFLPQQFRVFHKGGQIFRDLAVRTQNDQASCAVVFGSSTAGGAYHPGLSDYTIFVQDQAQVFLAGPPLVKMATGEIIEAEELGGARMHGTITGLADQIAVDEFDAILKARDWVSTLKIPDRPTRHLRQIMAPRYPIEDIFSIVNPDIRKPFDMKEVVLRLVDDSRMATFKPAYGPNLLTCWAQVMGIPVAIIANQTPIINPDEASKGAQFVRMCNQQNTPIVFLHNVTGFMVGSKSEHAAVIKKGAQFVSAVSCSKVPHISIIMGASYGAGNYAMCGRSYRPRFLFTWPTGRCSVMGPEQLSGVMAQVEANSAKNKGIVLKAEDVEARVQRLRAQVDRDSSCYRTSGVVLDDGVIDPRDTRDVLGMCLEVVQSPKIQGSSGHRGLARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZX40</accession>
    <name>A0A0D1ZX40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237478.1">
        <property type="nucleotide sequence ID" value="XM_016378801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZX40"/>
    <dbReference type="GeneID" id="27331536"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04453"/>
    <dbReference type="HOGENOM" id="CLU_323385_0_0_1"/>
    <dbReference type="OrthoDB" id="4161807at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="407"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="850"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="896" mass="101431" checksum="1744FAC07F2E71B1" modified="2015-04-29" version="1">MVHLQWGLRRFFRRSSNTLHSHEGETSNTPSSVSGVDYQVVSRSDDTRFLTPDPGNTQTRVRRQSVSRESVRSRASSIQSRRRPSSSVSRRQYVREPGLEQAIAAHGTVRLNASQIRCTLIVANHQGTGASAEGVRHEVARIEQLIVEFEEDAAFDELHDKAVQHLVRRFNRTAETYYLKVGRFRLVREEPRTVAARGILERKEDWTENLGRKVQAFRGQNFQVNFHVDIEWEYSSLHIEQVPGTLYAETIRRALESKIRLNWEDKLYVPRKDLRQIMTEDTIKKLVLDDKSLNDTEARRLNGFKPVDLDALAKDIYTWAVCLLAWCIYSDLQLVCLYHMLKKGLQDKDLPLTIDNCPDEAYTTKFRICATHSGGFAAYTFARNEKHLVDHQVLPDNAVVPILFDQRDPKSKLGEGSFGVVSKVRIDRDHHEFSDREDEYFAFKRFRDVGANVAASVKAESEVLSKLADAPHTNITTHIASWRQKGNCYMLFRCADCNLRTYMTVNPSPEWTKANLLSIIPQMAGLADGLNHIHNLGPANLQPEEVDLPARGAHRRSSQAGFHHDLKPGNILVTMNEDTGQLLFSISDFGSARIGQILSGSERPSQFTRNRHPGDPVYGAPDVLIDGRNSRPYDMWSMGCILLELLSWMVGKEGYDVKTFEQRRFETLANPNGDQDTTFWYEDMSSKIKLKPAVVDQLRMLKTYCEGRGVFEDLVRETGRLLNLQPRKRPEASQLSGAFKGILLQLNQDLKNENFYLSNAPPRVALAAPPTPTEAMGGLSRTHSIDEGGVHALYPESLLPDPRTHRRSTVGSIHPDAGLRRAAGHARHHSDSDALGRPMQLRTDVHTFAQPSSFSDSDQHETAPNTPRISLSDFDDDPERAVELNADEPVPYTPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZJ3</accession>
    <name>A0A0D1ZZJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_02420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238348.1">
        <property type="nucleotide sequence ID" value="XM_016376778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZJ3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZJ3"/>
    <dbReference type="GeneID" id="27329503"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02420"/>
    <dbReference type="HOGENOM" id="CLU_030117_2_1_1"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="23"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="487" mass="55368" checksum="DDD12C3467FA6B65" modified="2015-04-29" version="1">MQFDPSLPKSNTSSPASFAYKSVRERWPTIVANAIKDVQRQIDCPQHGNPEIVRQGMQIIAELECLKHEMLQNCTLSLLPDEEGELRGDVAIYNQELQEREAQSAKLVVRWHEVEWLFSECYLYRRLFGSFSRRTWWKTYDVFQEQKRDAFRQSKDAVLEMAAYYVNVTKGIGCIGCNSGFLASPDATQRQQAVFTEMMQQCLWGNATDLSLLTTLTYENIQQLQGSEVFKRRRDKVLVNDLDQAFNLLWQAGNQGEERRTVEFVLDNSGFELFVDVVVICYLLKSELATEVRMHAKQIPWFVSDATPTDIEQLFDIIRRPLDFFKDSSGSGEGGLAEMTDEQRQHLEVLHSDLRTFQAEGRLVYQTSNFWTQAGSFWRLPTSNPGLLAELRSSHLVVFKGDLNYRKLVGDACWDPTTPFQEALGPLGKSSKLNILSLRTCKADVVVGLPPGKDEELRSLPGCGGESGLRAWALDGSWAVMQFSKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZU0</accession>
    <name>A0A0D1ZZU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="14">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_02540</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="14"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238468.1">
        <property type="nucleotide sequence ID" value="XM_016376898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZU0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZU0"/>
    <dbReference type="GeneID" id="27329623"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02540"/>
    <dbReference type="HOGENOM" id="CLU_004962_6_3_1"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW18252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="536" mass="61279" checksum="F1A6BFF0EEF52E4A" modified="2015-04-29" version="1">MDGALAKAVVDKKPVPEIDFTLHIMEDGSQVSTQERVCKDVQAPAMQVPTNEQFWSPTDPSKPNLAFLKQHFYREGRLTEEQALWIIGEGTKILKAEPNLLEMDAPITVCGDVHGQYFDLMKLFEVGGDPSETRYLFLGDYVDRGYFSIECVLYLWALKIWYPDTLWLLRGNHECRHLTDYFTFKLECKHKYSEKIYDACMDSFCALPLAAVMNKQFLCIHGGLSPELHTLDDIKRIDRFREPPTHGLMCDILWADPLEEFGQEKTGEYYIHNHVRGCSYFFSYPAACNFLEKNNLLSIIRAHEAQDAGYRMYRKTRTTGFPSVMTIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCTPHPYWLPNFMDVFTWSLPFVGEKITDMLIAILNTCSKEELEEDTPGTSVTAETPPLSDAESIEAKRRAIKNKILAIGRLSRVFQVLREESERVTELKTQSGGRLPAGTLMLGAEGIKQAIHNFEDARKVDLQNERLPPSPEEIEKRSAEDRRIALERAATEAENDAQLQGVARRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0Q1</accession>
    <name>A0A0D2A0Q1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_02810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016377168.1"/>
    </dbReference>
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    <dbReference type="STRING" id="91928.A0A0D2A0Q1"/>
    <dbReference type="GeneID" id="27329893"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02810"/>
    <dbReference type="HOGENOM" id="CLU_053006_0_0_1"/>
    <dbReference type="OrthoDB" id="10254418at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="324" mass="32809" checksum="6580CF5ED18CF03A" modified="2015-04-29" version="1">MASLALSAASGAIFGSALTASGVYAPSVIISQMGLSNFHMLKSFLAASACSALIVVGANRSGYAHLAPRTDSSYGWFMRYDANVVGGLLQGVGMTLTGACPGTVLVQMALGIQSSWRVAVGGLLGGIVFAKSGDAIKRSHPPNTGTGKHTVQAKTGLSTPPVVFIYEALCVLMITAANYLAPTRKHWLHPVLGGLLIGLAQATSVLFTRKTLGVSSAYQDIGKYFWSVLEGKAGPGLSNIVFAGGVMAGSKIISQYVPIAADSVAGVSTPAAVAGGFAMIFGARLAGGCTSGHGISGMSTMSFSSFITVAAMFGGGIAAAFLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3C1</accession>
    <name>A0A0D2A3C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NCS1 nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_03687</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239608.1">
        <property type="nucleotide sequence ID" value="XM_016378038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3C1"/>
    <dbReference type="STRING" id="91928.A0A0D2A3C1"/>
    <dbReference type="GeneID" id="27330770"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03687"/>
    <dbReference type="HOGENOM" id="CLU_026016_2_1_1"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF7">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="56229" checksum="C5D74FF097800A7C" modified="2015-04-29" version="1">MKESEVKVGATATDPPPSLENGVVDENTTRLGHGEVDVIKIQEGNAVLRKLREAELWLDRKLKIEGMGAERIPDSERHPPHVLNMVIFWFSLLMSPGYITLGMLGPTFGLSVNKSIGLTVIGAATGSIVPAFTATLCPALGLRQIAASRFAFGILGSKLCGLLNIAVNVGFGTINCIVAGQLLAAVSDNSITDVAGIIIVVAVSYAVSFFGFRIIHWYESVAWILIFVLLLCDYGLSARYYDPHPGRSQLSGLDETGSALSYFAIIFGGAAAWCSMSGDYYIHYPTDTNKWMLFSLTWTGLAVPTIFVTVLGNLLGGIITSHEDMGNVYDTGGFGALIVATLRPSGFAKFVGVMYTLSFIGNEVAILYSSSLSIQLWGRHFLAVPRIIWNTLLAAISLGLAWGGRHVLHSIISNSLSLIGYWTICFGVILAIEVFYFRPKIGYDVEGWQDKDRMPVGLAGISTLLAGIGIAFVGMAQTWYIGPAAKPIGAYGGDVGNYFVLVIVTMLYPVLRSLELKKFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4A2</accession>
    <name>A0A0D2A4A2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239893.1">
        <property type="nucleotide sequence ID" value="XM_016374617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4A2"/>
    <dbReference type="STRING" id="91928.A0A0D2A4A2"/>
    <dbReference type="GeneID" id="27327334"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00251"/>
    <dbReference type="HOGENOM" id="CLU_1786860_0_0_1"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="145" mass="16105" checksum="37EE555F40298108" modified="2015-04-29" version="1">MLASPRTLLKGGRTDLRRDFNQSLNRANPAIKDGVGNSLSLTLQPNDTEQSSQHYSEITMPAALDLANPDRTIHVGVVLMGGETEILDVAPVDFFHGLTKDSIQDWPEDWLDPKLREQAIDFKFHWVNETGNPAKLTGALPSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A960</accession>
    <name>A0A0D2A960_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_01902</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241538.1">
        <property type="nucleotide sequence ID" value="XM_016376262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A960"/>
    <dbReference type="STRING" id="91928.A0A0D2A960"/>
    <dbReference type="GeneID" id="27328985"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01902"/>
    <dbReference type="HOGENOM" id="CLU_009193_1_1_1"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="427"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="824"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW21322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="905" mass="102526" checksum="E017F1C6951E5034" modified="2015-04-29" version="1">MSSSDDDMPLSGSRKPNGTNGVTSPLSSSKISSKVDATMDRQIPSKGETIPGISIANGDVKVEDTTMTDVNGSLTNGGLVKRKARESNTRPSYAEAESSDDDQPLSKKRRTTTAVESDSDDAPLLPKAKANGKVVQKPPRANAAQIGESSDSDVPLGKKLVKEKQQIEKAADKEAKQIRNKEQKKEASKPVKKSPPAKKVKKEDSSDDDKPLARKVSAPTSKKSKAESSTPVRKPAAKAKAVKKEETADPEDDEDENDEVKWWEDPTKGDGTNKWETLEHNGVVFPPPYEPLPGHVKLKYDGIPVNLHPEAEEIATFFGSMLNSTHNVENPTFQKNFFKDFTESVKKTGGAKDKDGNKIAIKEFSKLDFRAIFEHYDAQREAKKALPAAEKKAIKAAKDAAEAPYMYCIWDGKKQKVGNFRVEPPGLFRGRGEHPKTGHVKTRVMPEQITINIGKEATVPPPPEGHKWKEVKHDKQGTWLAMWQENINGNYKYVMLAASSDVKGQSDYKKFEKARELKKHIDRIRKDYRKDLKSELMADRQKATAMYLIDQFALRAGNEKGDDEADTVGCCSLKYEHITLRAPSTVIFDFLGKDSIRFHEEFEVDPQVFKNLKIFKKPPKKEGDDIFDRLTTTQLNNHLKNYMPGLTAKVFRTYNASFTMSKLLSEMKSEGTILEKLKDYNDANRKVAILCNHKRTVAASHAGQMEKLGDRLKGVKYQQWRIKQMMLEVDPKIKKKKGAEYFQLPDDIDEAWILEHQAYLVEEQRTKITKKFEKENEKLKEEGQKPMKQSELNDRLDAVKDLEKKFKRENKTKKVEPEGKSPSVEKLEENVNKLDQRIANMEIQAEDRENNKEVALGTSKINYIDPRLTVVFSKKFNVPIEKFFSKTLREKFEWAIKSVDENWTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AA62</accession>
    <name>A0A0D2AA62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241863.1">
        <property type="nucleotide sequence ID" value="XM_016376587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AA62"/>
    <dbReference type="STRING" id="91928.A0A0D2AA62"/>
    <dbReference type="GeneID" id="27329310"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02227"/>
    <dbReference type="HOGENOM" id="CLU_009353_1_0_1"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF23">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="743" mass="83243" checksum="71A5FFEF917B2784" modified="2015-04-29" version="1">MSSAPSSPAPLGNGIKRRRDEQRMTGPRKRTVVACDVCRQQKEKCEGGPPCRRCTRLRKNCRFHGMPMDRSRSGVSSTIREASSQLNAENTRDSRVQDLEYIARDFLGLPDSAHLDDFEIRQAVEKIADPVGSGGHDGHQGLQTSGPNVEEESFDTRFVSKVTAHYSGEFSHWNFSQKLWRRVSQRLERSGGNNLGQRIQVKDYWRPTQLQSPVNIVLQTMEHLPPYHVAQFLVKLFFKHVQLNYFFIEEDWISAKLQHSYSESPEFSASDVSWVCSLFAVLAIGTQVAHIESESATMAEEGEDLTMCSEDDVGKLFFHSAHSLVPDVIALASQESVQACLLLATYAMPLSTGGLSYTYLGLAMDMIILNGMHRKYTGSGCDARTIETRNRLFWTAYSLQTYIGVMHGRPVSITKSDINVERPVNFPGLRSPNFGNLIAFIEFNDCLAESANALKQFKKCPRSLALEYAARLLQVRDRIKRWWDTQACSNIERQNGDVTPSSRRANAHLKLCYLLLYIYVGRPFLFSDTPSRRPPATGGNPALHQQSIGITGISTLADECVQAATQIIDLLQSLYETIRLSRACYTEFSSCRAALLVLLAEWLRSGQRKRVSIALDRGMDLIQQMIGGNSNKSEVSLIEYLERAIKHISASLPSEDRLNNHHPADRELQSAYSSFKTWALTRRAENVPQSNPPPSSLGPHPISPSRSQYGLVDAADLFNTSWSFSDDDGSLDPFLLPLIPSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASQ2</accession>
    <name>A0A0D2ASQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_11853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229969.1">
        <property type="nucleotide sequence ID" value="XM_016386161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASQ2"/>
    <dbReference type="STRING" id="91928.A0A0D2ASQ2"/>
    <dbReference type="GeneID" id="27338936"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11853"/>
    <dbReference type="HOGENOM" id="CLU_096862_0_0_1"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="88"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW09753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="251" mass="29049" checksum="C8846B9995F44004" modified="2015-04-29" version="1">MANCTDSSILKTAPRGKDYTCNDGSTVTLSTRPNLRSRLIEVLLQRSKHETRTSLAGQPLIIGNDMDQQEHRRSPTEKSRPKGQLEKFQVECIKRSKYDLDRQEVLYEIKWLGYRDAENTWEPRENLLPDCLINLFVHHYLIGSTPLPFHKPPRYTTRQPPTQPTNEPSGLVERIINNDNFSFHVDWMSQVLQTDWEQEVVEVEDLHFSSSGEPVAVANTSNGQRHILTTEWLALHCPLKMLRFYETNGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AU85</accession>
    <name>A0A0D2AU85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NCS1 nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230529.1">
        <property type="nucleotide sequence ID" value="XM_016385585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AU85"/>
    <dbReference type="GeneID" id="27338358"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11275"/>
    <dbReference type="HOGENOM" id="CLU_021555_3_1_1"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF15">
        <property type="entry name" value="NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="62318" checksum="EF5BB14789EDC181" modified="2015-04-29" version="1">MTTMKRIFKRLEVKDHDEGALDKRVNHDIRPLEPHRRTYGPWQFVTLWVITGSFNIGGWTTGSSLIALGLNVWQAMLTVIIGNVLVGFLCVASGAPGAKWHIGFPVIQRCSWGTRGFRFIVIQRIFLACIWFSTQVYWGGQCVRVLLTAIWPSFAKVDTPLANGTMTTGDFTGFIIFTICYLPLVWIKPEKYKIPFLISCAIVIPTIFVSLVWFTAKAKGAGTLVHDVSGLTGITQAKGSHLGWMMTLGICTNISSISVHIFVQSDYTRYARKPKDQILAQLVMVPMGTIVVALIGIICTSCAAQLFPEQEGALLWAPYDLFSALQQHYDNSSRSRAAVAFAAISFGVAQLGMVVANNGVSAGIDLAALLPRFFTIRRGMLLMSCLAFVVQPWQLLNGASKFLTVLGGYGVFLGPMTGVMFADYFVLRKRLIKLTDLYENHPGSIYWYFHGVNWRALVAWAMGVWINVPGFAEFVKYGSTKTLKGWSNLYDISYPLGMLLSVLTYVLLNKFWPIAGLAEVDDLDFFGTFGPAETRSLHGEEVETVKVAQDGKTLVTDTDKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AW84</accession>
    <name>A0A0D2AW84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230976.1">
        <property type="nucleotide sequence ID" value="XM_016384374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AW84"/>
    <dbReference type="STRING" id="91928.A0A0D2AW84"/>
    <dbReference type="GeneID" id="27337142"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10059"/>
    <dbReference type="HOGENOM" id="CLU_079400_0_0_1"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="225" mass="24939" checksum="8E6E78A7F36556C3" modified="2015-04-29" version="1">MAPRIAIPPGETWFDMHNTDFPDVSVSADGEVSTTEFLSATEATTTIFDMLGSAVFTPIKNDMLFNVGRVRSRQAQDPRSSEMLQGLVKNELATRAHSATAGLTWLVRGLDFLSHALRTDLTQNNGISATEKFPKIDLRESFRDSYKVTLSPYHTAMIRPIFRAAMGASPRRKDLYIRLSGKGTDPEMAVQAMEKWVIAVETIVTILKDFLASDEVKASLPESIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXQ5</accession>
    <name>A0A0D2AXQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231451.1">
        <property type="nucleotide sequence ID" value="XM_016384849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXQ5"/>
    <dbReference type="STRING" id="91928.A0A0D2AXQ5"/>
    <dbReference type="GeneID" id="27337618"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10535"/>
    <dbReference type="HOGENOM" id="CLU_089876_12_1_1"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="151" mass="16194" checksum="F81B91C3571042F7" modified="2015-04-29" version="1">MRITAAEPGKVNFELPIEKHHTNRLGILHGATLATMVDTSGSLALASRGLYSTGVSTDLSVTYLNAGGKIGDLIKGEVICDKFGKTLAYTSVKFMNSKDEIVARGSHTKFVALAWKDDRNITEDLKPAVNESKASEATRTSFGGRNHVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AY52</accession>
    <name>A0A0D2AY52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231849.1">
        <property type="nucleotide sequence ID" value="XM_016385247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AY52"/>
    <dbReference type="STRING" id="91928.A0A0D2AY52"/>
    <dbReference type="GeneID" id="27338018"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10935"/>
    <dbReference type="HOGENOM" id="CLU_542945_0_0_1"/>
    <dbReference type="OrthoDB" id="2754405at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="518" mass="56850" checksum="0A7EEC9DA9594636" modified="2015-04-29" version="1">MDWKPLGGVSICSALCLFFTVIITAVGAAVLPRQIGQNVPARDWQSAVQNINGLNSVLTLLPVLTGKVQNVKLVACRIYPASFVVAGVGAGRVLSKLQVGILLWSFELYRNTVGELSYAHDEYVNKFSPTLEHIPTGTAERHSTSLIINHNPAEVYMVEAWFRTRGVPSIIKLKQNNYIRLALGSFIYLLLYGAETFLAVQNGADGTTKLLCAVQAICVSAWLSAVVTVQVVRGQGNPEIELNRLESPEYRCLRMPTLGTNVICETFSFHVANLTEFKLYGAKYEQPVLSVAGVLILTSATLDIISTVLIVGLTSWAYPWIGFEVVVILIKVVFCIEPMREIEIASARPHGGNAHQNPQITNPVTLPALLPLKIQLADPFTCSFVSTDYNVFREANAGREWRSTSAGVSIGQTYTAVGDDGSPLTKCLAHTQDGKLLSLADDPPTPQSNEALQREFLAALSVVVEANRVPSVEFVTAIERTLCQVESTMEPSWYAFGAKDVTDRVKKARRDLHWRRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYA8</accession>
    <name>A0A0D2AYA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_10690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231606.1">
        <property type="nucleotide sequence ID" value="XM_016385004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYA8"/>
    <dbReference type="GeneID" id="27337773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10690"/>
    <dbReference type="HOGENOM" id="CLU_745954_0_0_1"/>
    <dbReference type="OrthoDB" id="4152608at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46306" checksum="CF7029EAF601EE17" modified="2015-04-29" version="1">MEDLLINKLNSLSIEMKNITTTTTTTTTVVHVDNSNANIFHLPTEILTEIISFALDSIDLCCSGAMKFTPYLEKPRPILDLQLTCKRFHCISLQALSKRGHVTVNLVGPVPIKDRESMKQVHKYYTSLLMAHFQPAIEKQRRQVLINLLPELNSQYPPAGINWAPCDPKCPPRADKDDATVRRVMVSHQAAAILVSGIMRSISLKHPGLRLRIAVHDVDWMCPDYRHPPAEDSQQRPRIIPFWDLTGVCGVVYHWRWLRVYCGEHNEFSDVFTTSTIAVAVNTHLRMAWDNYVPAKSAVITALSAGGTALAHHVFQASLTKLMNTWVGGPMAEWSRTTVASPVRVYIPGYQEKVVCAENMTFAQWLTTICANSLYTKCFALRGVGARQVAGPTEMALELDEPGGRTLMLHGCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3B0</accession>
    <name>A0A0D2B3B0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233609.1">
        <property type="nucleotide sequence ID" value="XM_016382906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3B0"/>
    <dbReference type="STRING" id="91928.A0A0D2B3B0"/>
    <dbReference type="GeneID" id="27335664"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08581"/>
    <dbReference type="HOGENOM" id="CLU_045202_1_0_1"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="347" mass="37380" checksum="53BB3C2D39095D01" modified="2015-04-29" version="1">MVPIAQRKHLGRDKFSAQFSLLKTQQYIDPAARTVTPTIHRTISWNASGGLIATGANDKTVRVWNPERTSPRSQTELRGHGHAVEKVLFNPVREFELASCSSDGTVRFWDTRSKTCVTKLDVGGEPFTLSWSADGSTLVAGTKGDVLIPISTAIPSSPVVLSRHKQSQQTNQTTFSNAYPPTDLLITRGDGSVQILDFPSFQPLHTISAHTSSCTAISYCPNGKYVAVGGSDAMISLWDTTDWVCRRTVSNSSSGAIKGLSWSWDGRYVVGASEEMGSGGGEGMSSGFEIYHAETGDVVHTIATGTSGIPAVEWHPNRYWLAYTQIEETRQGKSSLKIIGAAGGPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B584</accession>
    <name>A0A0D2B584_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_06824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234259.1">
        <property type="nucleotide sequence ID" value="XM_016381157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B584"/>
    <dbReference type="STRING" id="91928.A0A0D2B584"/>
    <dbReference type="GeneID" id="27333907"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06824"/>
    <dbReference type="HOGENOM" id="CLU_033348_0_0_1"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="452"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="296"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="419"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW14043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="586" mass="63265" checksum="7D4B529CCA081845" modified="2015-04-29" version="1">MGRTSPQGLMASDFHHQSFVNPLDVFPTKSRLAGRQNYRSPLRGQVVSRSPARYAAEAHKFACCGEEEAPPAFRPLGAMNQVTHETTPDDGFGIPESSSSRNASLHNSPSPMDCEDCIDDCDDCLEEHQLYNHQADDQYVNNCQDCNDAQIDHKYNGRICNDTCDECDFSCFDCIDWNEFEQDKSLGLSFSVPLLGDNSLPVSEPAPQFDENELLNFQSPDFSSMQSEPMAPPLDVPMHHQCFGNTVPYWDSIAQAQLCSGAPGMAQQYPLPPFGMEFGCHPATAHQQLSLPDLASLSSTPAAFPPSPVTKPEPQPKPEPSETPLSKTSDLLSAVSAPPTSRACQWLMPCGTVCGASFASATDLKKHLKAVHLVKGVTKCAWQSCDSATFTSEAALTGHISKKHLAPMLAAAAAASSSASSSEKNSASRSSASTSASTASSVNAATGEGGPFKCTFPGCAKSFMYKQVRDDHVASCHQGNKMYCHICGQYLNGEGSNFKRHMATHRPKHQHMLCKFHGLGCKRRFPRLDNLRRHEACCKFGKGKKGLLANGGAAGAGAAVGVGVDDDGDKLKHHHHHHHHVHSAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5B9</accession>
    <name>A0A0D2B5B9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06676</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234111.1">
        <property type="nucleotide sequence ID" value="XM_016381009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5B9"/>
    <dbReference type="GeneID" id="27333759"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06676"/>
    <dbReference type="HOGENOM" id="CLU_000960_25_1_1"/>
    <dbReference type="OrthoDB" id="2587356at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="55"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="601" mass="63899" checksum="67430D1651FF62CD" modified="2015-04-29" version="1">MASGVEEPERPPRVAGHEVEEKPCTSEQQIEILHSSQKNLNYDEADQEPVLHARTWIALGAMVMLNMVQLIALNGPPVFLGTIAAEFGQQDLQSWVPNSLSLVQAVLGPVISSGSDMFQARKTLLVGSCLIAVVGAAIVPRSQSLYQVIAGQSLIGVGFASVPLAYCVPSEIVPRKWRPMVQASMQIGGFAGAMIAPVILGEFLQADSVGGWRNFYWVQMSLWALTTIGIFAGYRPPKRHTRLDHLSAWQKLGMMDWIGSFLVTAGLTLFLTGLSLGGGLYAWTNARVLSTLIIGGALLVAFGLFEWLGTKTGIFTHELFTGPNGAGRTAWISVLLIFIEGFVAASFVIFYPVMTELLFTTEPMKVVARQEGFYVGCFIGSAVFGYLSSKLRSVREGTAVGYLLLTGGLVGFATIQPGDSVNAIAFAVLSGLGLGVILALVISAIQLCTPHHLIATSTAVLTTTRALALTVGVSVYSAVFTDAIDKKTPAMIASAAAKNGVPVTSIPEFVEAFLGKDSNALGKISGVTPSVLAACAVAVKHASADSLRLVFIIAAPVSALAVLLCYFMADLRTLMDYRVDAPLEELHAKQHDGEDDGHKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5U6</accession>
    <name>A0A0D2B5U6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234514.1">
        <property type="nucleotide sequence ID" value="XM_016381412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5U6"/>
    <dbReference type="GeneID" id="27334163"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07080"/>
    <dbReference type="HOGENOM" id="CLU_804194_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="345" mass="37352" checksum="1B65C835EC3B624D" modified="2015-04-29" version="1">MESLLPPKEPPTNTGIEFSMFGSLVWTDNRQWPSTSENLRKDMAEAPEYPTPLEAFTLASLKPSSKPRSQYPRAVVPQRLEESPGRGTFSARALTLPPVVTLRGLTREDPIVVDDDGSDSDDGPTQGGSHRVEPTRSRDCQVGLIAPVVNGRSRNGLPPFNAKVDVTDSVNHPKPAPELTDVLARIAKDVSDSVLSHLEPVVNFLNQGSATEPQSEDNRPPPPATEASASGPQPQSDDDAPLDTNGDSPGHNRGIVQNEYPFIHNRGITQDEYSFAHNNGVIQSENSFIHNRGGTAFFSLSYTNTRIFCIGKTTGAMAKTKTTAPADHNNGNGLNHHRNHGNKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6F7</accession>
    <name>A0A0D2B6F7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234496.1">
        <property type="nucleotide sequence ID" value="XM_016381394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6F7"/>
    <dbReference type="STRING" id="91928.A0A0D2B6F7"/>
    <dbReference type="ESTHER" id="9euro-a0a0d2b6f7">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="27334145"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07062"/>
    <dbReference type="HOGENOM" id="CLU_006586_15_0_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004104">
        <property type="term" value="F:cholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112826" description="Carboxylic ester hydrolase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="32"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="4">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="526" mass="57167" checksum="E10652927A902E8E" modified="2015-04-29" version="1">MVKFYLYSLSLALSLLNATSSSFAQQVSQNPPSATIDSGVVVGLATSLSEGGFPINKFLGVPFAASPVRFQPPAKPTPWTKPLEASKYRPACIQQLATQDGIPPAQVASWSNTPPPPAGESEDCLNVNIYAPNSTGMKPVMVWIYGGGFALGFNSDPRWDGSFMAANQDVVVVSVNYRTNVFGFPMSPQLPLSQQNLGFLDQHFALDWVQRNIHSFGGDPKRVTIFGESAGAASVDALVTSYDENPPFVAAIMESGQITFYPNTPNATAPWKNMVARLNCSSAPDVLACVRAIPATEIKSTIEGPGNFAFGPVRDNITFISHSGVARQQRKIAQVPILIGNNFQEGRLFVTAYNSTQQYLERTLPNMNQSFYNRVLTAYPLGSPGISNEFERAAAIDTDFRFLCPTAQVANYSSMAGLQTWRYLFNASFPNTQLFPDAGVYHSSEISEVFGTYPRGDVTTKQESLSRYMQKAWADFAKNPTGGPGWKAVPNVAVLGQSEQEIEQNMPGTTIDNICALYMPLYSALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7D8</accession>
    <name>A0A0D2B7D8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234791.1">
        <property type="nucleotide sequence ID" value="XM_016381689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7D8"/>
    <dbReference type="STRING" id="91928.A0A0D2B7D8"/>
    <dbReference type="GeneID" id="27334442"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07359"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_1"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="316" mass="33394" checksum="5A96083B47965BA8" modified="2015-04-29" version="1">MRKCFSTCATSLSHENPLGLPRSSKPPPPTIPRAQRGLPAKRPVPNVRHTIAVSSAKGGVGKSTLSANLALSLSRHGLRTGLLDTDIFGPSVPTLLGLTDPSISQPTTTPSGRLVPLTSHGVRSMSMGYLLPSESAPVAWRGLLVMKALQQLLWDVDWSPGLDVLVLDMPPGTGDVQLTIGQQVTLSGAVVVSTPQDIALKDAVKGVEMFKKMDIPVLGMVQNMSVFVCPKCGEETRVFAAHPHSHGGGGGGAESKARDLGVDFLGDVPLDARICADADRGMPTVVAEEASGVKVNTRYYERIAEQVARKIGLDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7P5</accession>
    <name>A0A0D2B7P5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_07698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235129.1">
        <property type="nucleotide sequence ID" value="XM_016382027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7P5"/>
    <dbReference type="STRING" id="91928.A0A0D2B7P5"/>
    <dbReference type="GeneID" id="27334781"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07698"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW14913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="252" mass="26306" checksum="98F69DCCE5D495D8" modified="2015-04-29" version="1">MSTLTTDLSSHLALITGATGGIGRATCLSLAHLGCSIAVHYNSAADTAASLVSQLQSLGVKAKSFQADLSAYNGARALHAAVVREMGDPTILFNNAGMTMGKSGVKDVSEISVEEFEQTWRGNCGTAFLLTQLCIPSMVGQNWGRVIFCSSVAGFTGGVVGPHYASSKSAMHGLIHWLAGAYGKKGITVNGVAPALIEETGLLPASNDDLSARIPIGRLGKPEEIAETVLWMVKTGYVHNKVVAVDGGWFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7Q5</accession>
    <name>A0A0D2B7Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234931.1">
        <property type="nucleotide sequence ID" value="XM_016381829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7Q5"/>
    <dbReference type="STRING" id="91928.A0A0D2B7Q5"/>
    <dbReference type="GeneID" id="27334582"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07499"/>
    <dbReference type="HOGENOM" id="CLU_097030_0_0_1"/>
    <dbReference type="OrthoDB" id="88561at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40781">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40781:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="9"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="227" mass="26063" checksum="D534F8C065798CB1" modified="2015-04-29" version="1">MERYACLNIPHELYRIDYPGSQTTFTSEKGFKATDTERTFGADDLHDFKQALESQFKWSCRDPVPFISLFSDQEHAENWGRKEPWRGNRGPDGSWALYVINAIELKETTPIFKLSSLVQMLKLVIPDGAQQHIQGAYLCLHRVPQAAIINKRTPGEIETGKCLGAGDTTCVSLIADRESRRARRLEEPDRYDYLGDCGDSDSDREMLQENYNSIFDRNIEDAWFSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7W2</accession>
    <name>A0A0D2B7W2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234986.1">
        <property type="nucleotide sequence ID" value="XM_016381884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7W2"/>
    <dbReference type="STRING" id="91928.A0A0D2B7W2"/>
    <dbReference type="GeneID" id="27334638"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07555"/>
    <dbReference type="HOGENOM" id="CLU_041939_3_2_1"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19177">
        <property type="entry name" value="SET_SETD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044429">
        <property type="entry name" value="SETD4_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="373" mass="42606" checksum="E2BB11F722D4B448" modified="2015-04-29" version="1">MSNHENLTEWALSRGYKLNGIKAHAFAGRGLGVLAERNIEPGEVLMTIPMSAVRTAETLPKKIIESLHSCSNNGLLAVELAQDESSEYAIWRQSLPSMEDFQTLPVTWEEGVAKFLPSKARGVLSKQAAKIQKDWDAVSAGHINISFEEFRYFWLLINTRTFYHTPPKMKLPPVNSDECLAVVPYGDYFNHADIGCKVSYSASSYEITADRRYDRGEEVLISYGSHSNDLLLVEYGFIFDGNRWDETTLDDVVIPLLSEDRKKILQDEGYWLNYHLDRDGACYRTKVAVRLLCMPLRQWRRGLAKGFDDDDRYKRIVNGLLLKVFGNYRSIVRGRLEQISKLTAGVHVQRDILRRRWGQIDAIILAAIEQIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9K9</accession>
    <name>A0A0D2B9K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_05692</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235859.1">
        <property type="nucleotide sequence ID" value="XM_016380032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9K9"/>
    <dbReference type="STRING" id="91928.A0A0D2B9K9"/>
    <dbReference type="GeneID" id="27332775"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05692"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="10">
        <location>
            <begin position="20"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW15643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="355" mass="37688" checksum="2819EA8A812AB339" modified="2015-04-29" version="1">MSGPFTSEVPPRSLAAVQDSSTKTICTQERDTPTPESTQVLVRISCTGVCATDLHLCRRDLPYLQPTVSVGGHEGVGDIASLGSNVNKSLWKIGDRVGVRWLHRVCLQCDLCTSGYENLCPNRKISGKDVEGCFAQYALADSEYLVRIPEMVSDPDAAPILCAGVTVYKALKIAQLRKGSWVAVAGAGGGLGHLAIQYAKAMGLRPIGLDAGKKDICLTIGAEAYVDVLETNDSVAAEVQRVTGGASGALICASNGRAYADAVKYLAKAGTMVCIGLPPRPSPIPVLPEDFIARGIKIMGTSTGTLKDTEEALDFVAQGLVKPRLVEKSLDDIESVLEDIEHAKVEGRVVIRMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAB2</accession>
    <name>A0A0D2BAB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PAC1</name>
        <name evidence="11" type="synonym">LIS1</name>
        <name evidence="14" type="ORF">PV08_05978</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236144.1">
        <property type="nucleotide sequence ID" value="XM_016380317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAB2"/>
    <dbReference type="STRING" id="91928.A0A0D2BAB2"/>
    <dbReference type="GeneID" id="27333061"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05978"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_15_1"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="13">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="197"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW15928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="457" mass="50083" checksum="9882371BD8043940" modified="2015-04-29" version="1">MSQLLTARQAEELHKSMVAYLISVGMNDSAVALRRESSLPESFDDATAKKYETLLEKKWTSVVRLQKKIMDLEARNAALQQEIDTATPLSSNRKVDPMTWLPRSPARHILQGHRLPVTSVAFHPVFSSLASASEDSTIKIWDWELGELERTLKGHTKAVLDVDFGGPRGGTLLASCSSDLTIRLWDPSDEYKNIRTLPGHDHSISCIRFIPSGAAGAPLSGNTLVSASRDKTLRIWDVTTGYCLRTLKGHTDWVRAVTPSIDGRFLLSAGNDQIPRLWDASSGEVKITFLGHEHVVECVAFAPSTSYVHLSGIAGYKKPPPVSSSGEFLATGGRDKIIKIWDNRGTCHKTLVGHDNWVRGLVFHPGGRYLISISDDKTIRCWDLSQECKCVKVVDEAHQHFISSIRWAPDVPGQPVTNGDSNGALTITKKEDGVGGGKIRCVIATASVDLNVRVFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BB32</accession>
    <name>A0A0D2BB32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236041.1">
        <property type="nucleotide sequence ID" value="XM_016380214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BB32"/>
    <dbReference type="STRING" id="91928.A0A0D2BB32"/>
    <dbReference type="GeneID" id="27332958"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05875"/>
    <dbReference type="HOGENOM" id="CLU_004790_4_3_1"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW15825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="67514" checksum="61B21FABA866E9B5" modified="2015-04-29" version="1">MASQGSANLLADVVASRPPAKVDETTRRVSVTLPGDVEGTNTQERALAYPNDEEEYQAPTEEEKATLRKVSAPVRLISFALCLVEFAERASYYGAKTVFNNFIQFPLPEGGNGAGAPPRHTQKTAGALGMGLQASSALTLLFTFLAYVIPIFGGWLADVHTGRYKAIVIGVLLAGVAHLIQIFGALPSVLQQGKSHAAPPFIIGLIILAFGAGIFKPNIAPTVLDQNRHQKAYTKVLRSGEKVIVDPEATATRTMLIFYGLTNVGAFYMLATTYSEKYVGFWLAFLLSGIIYFLLPILLVVMYKRTYKAPPAGSSDLANALKIIGFALKKSKFQPWKKNFWDQAKPSVLAAQGVRVSWTDELVEDIRRTIAVCEIFFYMPIWFLNDGGIGSVSTNQAAAMTTNGAPNDLLGNFNPLTIIVTVPFMGYILYPTLERWNVKPGRITRIVCGFVCAMISSVAGAIIQWRVYKTSPCGFQASTCDGVSPISVWWQVPIMVFAAWSECFCAVTAYELAYARAPPTMRGLLTAVYLFMNGLASALGEILIPATKDPWLIYIWAGPAVALFLQTILFWFRFHHLNNDEFMLDHKIQQATDGQGSAPGYDVEGHDVEKKILEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BB65</accession>
    <name>A0A0D2BB65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_06309</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236474.1">
        <property type="nucleotide sequence ID" value="XM_016380647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BB65"/>
    <dbReference type="STRING" id="91928.A0A0D2BB65"/>
    <dbReference type="GeneID" id="27333392"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06309"/>
    <dbReference type="HOGENOM" id="CLU_065214_0_1_1"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW16258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="241" mass="27314" checksum="E0B4C409853997CE" modified="2015-04-29" version="1">MADQEHQQPQQQQQLPEAPFPAPPPFWRHFTTANEEKLKEIESSEPGRSEKLPIPLAYLRPPPPPPESAEVYTTFGQSQVIDPSKPTSLPRDQLLFDPDSPNLNHAVLLSKMTKSLMLNFLELTSDLSLDPTSYEEKMADIRQLVLNIHVVINMYRPHQARESVKEMLEDILEDGEREMEESDNLKQKVEQFLGELGNTAAHAGSAMATDLNGETSTIGNENPKLDEQRRLWDMIDEMTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF41</accession>
    <name>A0A0D2BF41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_04436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237461.1">
        <property type="nucleotide sequence ID" value="XM_016378784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BF41"/>
    <dbReference type="GeneID" id="27331519"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04436"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000670">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF81">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="556" mass="59706" checksum="77B56FA2ACC1F17F" modified="2015-04-29" version="1">MHSFPALSQTGRQAVISSEHTTNKPDEATPLIGGGADITDQIEEKWKPGPGFIWIEIAIFSNVFLSGFDGTITASTYAVIGSEFNAANTISWLTTSYLITSTAFQPLYGRFSDVLGRRTCFFTATITFLLGCLGCALAPDIITLNLMRALTGLGGGGLMTMATIINSDMIPFKERGMYQACQNVLHGFGSICGASLGGLIADTIGWRWCFLCQVPVSLFAFTVGHFVIKQDDKQLTSDEEAATGPVHASRWKQIDVGGALFLVLGLSAQLAALSMGGNDYPWGDARVLTALLVSILLLVAFVQVEIRTGALAVMPMSMLKGTLAVSNLVSNVCVGMAAYSFLFVLPLFFQVVLQDSASQAGMRLVVPSLATPVGGVVSGIIMSRWGRLSELVRTGCLLMMVGNGLVASLKYEDSSWKYLVYLIPANFGQGMSYPAILFTFLAAFDHDQQAVSTSMVYLFRSMGTVWGVAASSTLIQNILAQDLPSALQGMPDQAKLIDEIRHSVSVLKKLPPDVQLAARHVYYTALRYAFIANTAVAAIALVSAFFAKGKSLHRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHH4</accession>
    <name>A0A0D2BHH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231030.1">
        <property type="nucleotide sequence ID" value="XM_016384428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHH4"/>
    <dbReference type="GeneID" id="27337196"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10113"/>
    <dbReference type="HOGENOM" id="CLU_1503452_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="179" mass="19918" checksum="8E6B3BC1D2683C4C" modified="2015-04-29" version="1">MKLPDGYVTEHHWAWSMSDPAARSQEPSTWAWEELDGTYLLGDAAKEEAHSLEEILKGNILAGSTREAVDGMNNDLGVGSNRDKFGATSTLSRKSPGRRGQQSSGDVVRKDKELTVDADRSVQSQRQDYTRTDSESSIDQSEKERCDCTECKSRRWRGDSTTQQGQGVSIRDRLNGVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHX0</accession>
    <name>A0A0D2BHX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Choline transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238719.1">
        <property type="nucleotide sequence ID" value="XM_016377149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHX0"/>
    <dbReference type="GeneID" id="27329874"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02791"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_3_1"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF16">
        <property type="entry name" value="7-KETO 8-AMINOPELARGONIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="55813" checksum="9B5307D77F9CF747" modified="2015-04-29" version="1">MGTAVKNALDKPRPESLVAEESPATSEGHMRRMDVTFSLWSTLGLVYSVTATPIAIGAYLSFSLVLGGSPFYLYGYIFAVTFNIVLCVALAEVSSLYPHPSGHIYWVGKLSPEKWSLFLSYWTGAFTSAAWFFWTSGTYLLTAQILSAAIQVLYPTVTPAAWHVVLMAWAQALVSVAWNIPFFKTWPYALKTMIFITNAGALFIAISLLVRANPKQSARSVFVDVANTSGWTSNGVVFFLGLLPGATSINGFDSAAHMVEEMPDPVRQVPQVMVGNALLSGFLGLPMIIVLCFCITNLDNLLAPVGGVTLIQLFNDSLDSEPLFIVCSLFCILATVIAATACTTTCSRVWWSFAEHQGLPFSSWFAVIHRTKLWTVPVNATLTTMVLSCLIILLNLGPSFVLGALFTAADVCFYMSYFITLGCFLHRKWSQGVPAHYFDLRFLSNTVAITGAVWAVFVSVWLVFPYYRPVTSGNMNYAVAIIGTVVAIFTVDWLVRARKSYLIPSPILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BI97</accession>
    <name>A0A0D2BI97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_02977</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238904.1">
        <property type="nucleotide sequence ID" value="XM_016377334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BI97"/>
    <dbReference type="STRING" id="91928.A0A0D2BI97"/>
    <dbReference type="GeneID" id="27330060"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02977"/>
    <dbReference type="HOGENOM" id="CLU_028556_2_0_1"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000477">
        <property type="entry name" value="General transcription and DNA repair factor IIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="17">
        <location>
            <begin position="84"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW18688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="459" mass="50425" checksum="A97BE831D4552E57" modified="2015-04-29" version="1">MPASGDEFIVDDDDDLPRAAGRSHARRATDRESGQNFEVTRTWDLLTEGADGTITGAVEGLLEAGKRKRLLKDTTPLQRGIIRHVILILDMSLAMNEKDLRPTRYLLTLLYTETFIREFFEQNPISQLGIVGTRDGVAIRISDMSGNPNAHLAAIQKIRKEEPKGNPSLENALEMARAALFHAPSHGTREILLIFGALHTSDPGDIHRTIESLVADKIRATVIGLAAQVAICAELVSKTNHGNLANYGVVLHEQHYRELYMAVTTPPVTSQATKSANSLLMMGFPSRTVEDRPSLCACHTRPSRDGYLCSRCNTKVCSLPSECPVCGLTLILSTHLARSYHHLFPLVNWLEVPWSKAYRSKACFACLKVFPPVPPREQWNSANASATSSRYECPVCRRHFCIDCDLFAHEVVHNCPGCQSLRMHTTLMGETETPGNVNGGSAQTKAASQATGGDPMSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIP5</accession>
    <name>A0A0D2BIP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uracil-DNA glycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_03097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239024.1">
        <property type="nucleotide sequence ID" value="XM_016377454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIP5"/>
    <dbReference type="STRING" id="91928.A0A0D2BIP5"/>
    <dbReference type="GeneID" id="27330180"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03097"/>
    <dbReference type="HOGENOM" id="CLU_042829_1_1_1"/>
    <dbReference type="OrthoDB" id="565731at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000010">
        <property type="entry name" value="G/U mismatch-specific DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="5">
        <location>
            <begin position="94"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="282" mass="31007" checksum="96FC340E74DC7FB1" modified="2015-04-29" version="1">MVESPSPRRSNRNLNKSSPGGTSSPTGSARKKRSWAIHSFAGSISERDDTSGLDSPPTNRDSSASTAKKRRSTTKERSAKDPHSPVNHLVDSLRPGLTLVCIGLNPGLMTAATGHAYAHPSNRFWHLLHDSGITPKKHTPAETRDLMDLYQIGNTNICERPTRSGDGLSKQELEEGAVTLDKKIAIYKPEAVVIVGKGIWEAIWIVKKGKKKFNDPDFHWGWQDEEMQLGRVVEADGHIVWPGAKTFVATSTSGLAATLRPAEKLAIWKPLGDWMAMKREET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJA6</accession>
    <name>A0A0D2BJA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238886.1">
        <property type="nucleotide sequence ID" value="XM_016377316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJA6"/>
    <dbReference type="GeneID" id="27330042"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02959"/>
    <dbReference type="HOGENOM" id="CLU_2291733_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="101" mass="11211" checksum="F5DBFAD672AFD369" modified="2015-04-29" version="1">MSNPIPRDETVDLLGVGMIHGASHVDNTPENVQDPLKDELDNLSRAVSLTAAVSPQKKGTRKKYIPVPRPDFAEEPWHGVSMVLKQSEHNAKRRHGKPGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJG0</accession>
    <name>A0A0D2BJG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_03313</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239239.1">
        <property type="nucleotide sequence ID" value="XM_016377669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJG0"/>
    <dbReference type="STRING" id="91928.A0A0D2BJG0"/>
    <dbReference type="GeneID" id="27330396"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03313"/>
    <dbReference type="HOGENOM" id="CLU_011455_1_1_1"/>
    <dbReference type="OrthoDB" id="2341546at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW19023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="757" mass="84621" checksum="357BAD3D2DE6250D" modified="2015-04-29" version="1">MDDFAYSGFATATISDQPISASNWMSDPRLDIRDTQYKLASRSVDGDGPGTGLTSPTQSHKRNASVAGFDSSPASASFGSPDLNDEHGRADGKRRPVKRACNECRQQKLRCDVVQEPFQTCSRCRRLNLECKIEDNFKRVGKRSRNAEMEREIVELRRQVAAQRSGSVSTSNGGFQNGNASLSLPQTGLASFTQDAAAAGLLDLREGKSPGRAIFKRLEDVAVTQDRVQELFQRFFTFQHPFLPFLNPERTPEEYHTRSPLLFWTILTVGARHYTPEPELFNALTGPLTRLMWSTIAEVPQNYHIVKALILLCAWSLPTSSTSTDPTFMICGMMMQIALQIGLHRPTHAQDFSKFRVELREVEMQDRVVVWSVCNIVAQRICTAYGQPPLTIYDWTLGPKPIETNPNYELPAPIYNRLLIEKFVDKVSRTLYMNAHDPVGLASDAERPTYVSFLAHDFEELEDKLRHDTSPITNLYLKAAALHMRLSAFFSPPSLPSYRADMFKLYQSTTQFLETCLGLENSMSVSLPSSYSHGLSLAHATNYIFHMMLAAGFSLLKLMHNFLDEHDMDVQGASELLSRTVWALRSMSVVENDLAERLAEVLAQVWKSGRVRAKPDVNKTGEGEVDDSLQLKVKCRMSVSLVFDSVWRWRRNFHFGGGKPSDVRQNDAKLQQADSVLIPSSLTTVDASVNDPMLSASAIVPGMAGMATGMVENNNGYPMDYSQASYDVFDPLNWMLDGIVDFPYNFNSSGIDTMGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL47</accession>
    <name>A0A0D2BL47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239899.1">
        <property type="nucleotide sequence ID" value="XM_016374623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL47"/>
    <dbReference type="STRING" id="91928.A0A0D2BL47"/>
    <dbReference type="GeneID" id="27327340"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00257"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12163">
        <property type="entry name" value="2-Hacid_dh_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="151"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="252"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="404" mass="43503" checksum="7AA3A38878E428C7" modified="2015-04-29" version="1">MGGGPDKEHLVIALGDPEPKHLTALLKQQFPDIDITYYQVSRAVGGFKDNKTLGSQIPDGQICLTGPSVSVMGSDQQDVALFVHLMRPEPRWSFITLLLIFPPPISSLKLIHLFSAGVDHWTDHPVVKDSNITITTSSGIHGPPITEWIIMTTLVASRHYAVEYEWQKERHWGQGEKFQLAGTDWVGKTVGIAGYGSIGRQAARVFAALGANIHAYTASPRPTPSSRKDTGYFVPGTGDPDGTIPSAWYSGTSTTSLHTFLASGLDALLVALPLTPATRHVFGAAEFDLLGSSGGSPKTKAAGAGAAAKPFLINIARGPILDQPALVDALNDGVLGGAALDVTDPEPLPKDDPLWSAKNVIITPHVSSLGKEYLDRAFDLFVTNWKRHERGEKMFNVVDRKKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLA3</accession>
    <name>A0A0D2BLA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LAA1-like C-terminal TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239954.1">
        <property type="nucleotide sequence ID" value="XM_016374678.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BLA3"/>
    <dbReference type="GeneID" id="27327395"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00312"/>
    <dbReference type="HOGENOM" id="CLU_000503_0_0_1"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1847"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="2028" mass="220848" checksum="94FF1098677086F6" modified="2015-04-29" version="1">MASSAPAPEQVPATNCTSDTELDIAKLHALPTEQQDLFLLTFVSDLQHHVESLSAEALPVHQASIKKEVIKIVGLGAPTPSRVVRNTLGRILADAFGRGSRSLLYETINDLVSILNTGKNDKEVGARHAAVVCLGALFRSAGDSAISLSGLVVASLLKLLKSSHTGTRGCVFRALDALVIGIQTSLDESVARDIWKQARGAAASEKSSFVQRCACSCIRSLVTETTYFNNSADFDSLKNSMWRAIDSSTSSVRHSAAAAMASALGQAFSDTGHIEVPVIRKPRKSKKPGADLDEEGEQDGAASPAPSQGKASVQLTMSLNEVLRVLSQQYCKASTSNRARAGIAMCYKYLLRLLPPKTLEERYATVAAHTYDDLLNNPTVSANRYRLLLTRKIVQWILNDVTGLLTENAQINAARYIINDVLKNYPQVIPERKEPSKRILTGALSTLTELLSRLGPASNVLQDSCREALFQVVQHPSHTVQSHAVQSLKAFVLACPSQLNRSIEHAMSQLQKEFQPSSEPKYPHRKSLGYASTIAVMISCVRQKPLYGSIQIYSNVFTFATELLKSSAAAELRVSAMQVQVAWTLISGITGLGPSFVKVHLNQLMLLWRNALPPPLTHENAAKRGHLELSFLSHVRECALSALLLFLSSCSTLVTTDGSKRISTMLHNTILFLESLPPTREADDIAHRLVPALQLQDLTILLRRRVLQCFTALASLKHLDQSEVVSHSDLIGLTTRTFTDPERPIMKNLETSLTNAASNFEGLWTTSDNWGFGVCSVSDSFDTYLPFENHVQLGQRTSPEQEVSFPDLSIQSPSLAAIEHDPVLVIRHGSDPQEAELSSPATSCVNLAIKLFAISLPLQSPRVQQSTVEQLITAISQPLQREPGKRAAMQINSALAFLCALAVANKETPYLAGKLNVDAIGPVIAELLGRYVCNGDQNLRHLAARAIGRLCNLAGTQFTNKEVKDLIDVIVANRDPSARAGCALALGYIHAEVGAMAAGLHMKSIVGVLLSLCSDNHTTVHYWALRGLVLVADSAGLAFSTYATSTLGLLAQLYSNDTHNEESASLAASNLELELFTPEALAQCVDSIINVMGPDLQDVSKARKLILILIGYLQNEASLRLRYESYLCLRHLMMYAPAHIQFSKYVLDLQENLSSDEELLQSSAIRGLGELMKRNASEVARVATSKLSDDLWRRLDDNPNDQSVQSLLQNWMQQTILLDTAEWIDKCQSVLSKTRAKNSPPRMTAVTAKSAMPDLADEEVAGFAAAAQSEAPEAAPDGQEFLRWQTRDFAMRLLSESMDIVQAAMSADRVIHAEEILQAKVGEVVRVAFSASTANVVELRIWGLRLIDQILKLFGKTPDPDFLEASLLEQYQAQISSALTPAFAADSSPELAAEAIGVCATFVATGIVTNADRMGRIFKVLSMGIDNLTQQTPEAAIGDLKDLSPNAQAMLKMAILSGWAQLQLASHEQAYLEDILQPFIPKLAPLWLTSLQEFAGLRFEPEISDTLGGEMVGGNLDERYASFNCEVRLKFYQKTWLSIVNAIAVLVEKDSESVFDALDNKRVNGAEDASANGTVVQGRDMSFREEPVAFFFILFGLAFEALVTQTREDPSQALSILQALRKILTPQVSGNAIYEDAVFTETTDTLDRLALTSTSDTQSVLVEIARNLSMDHLVAKSQDRDEKLSDDIEQLFELTRIIILVLTGLVPTLEDPPGPAVRRLGEDSVGLVQLSFQALVDVASVFPSIIRADLHACIFYSYCTILATGVCQDEVIPRIMPVFKTFLQDVVRSSNIQTSSRLVRGCLHRMLAILSAAQRRENEHAIVCAKNTLLSIAVLITTASSVVAAKDELIDGALFDMLDCLHDVGLAKITTGCLRSLLMTHPKTACDEYIGRILWGRLVPFVTDPEADDPESVKGALTQALVASVVTLAGPGRLAAMSILIPVLMVRATQVPGGSNLQDVRKECAARLLDLVAVDQFAFKAAVGSLGEEQRSDLENLLRAAGVGEKQDTTSMDNVESRPAIELRMDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMR6</accession>
    <name>A0A0D2BMR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240076.1">
        <property type="nucleotide sequence ID" value="XM_016374800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMR6"/>
    <dbReference type="GeneID" id="27327518"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00435"/>
    <dbReference type="HOGENOM" id="CLU_043410_0_1_1"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35537" checksum="31087F5BB0265155" modified="2015-04-29" version="1">MIAPLEEQTDAVHVLISPEERASGQISKQNLEQAVVALSENGVVILDNAVSEESLDLLNPRMVEEAKVLREGSSTWFNYDAKAQNILQHMIPDPEYLLPDVHANPFAVAVCKTMMGPNPVLRYHKANTNFPGESRQPVHSDVHYEHPRACFSLAVNIVLIDCSPENGSTECWPGTHTTTKFSDQNGMKGIHQHLLDERVGTHGPPIQPTVKKGGVIIRDMRLWHAGMPNRTADQVRVMLNLIFFADWYRCPMTIQFPKSAEAKIRELEKQGGIQIAAEFVDDLDHRTLAHTHDFGQDDKREEFGRWHHKVPPAKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNS3</accession>
    <name>A0A0D2BNS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_01113</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240754.1">
        <property type="nucleotide sequence ID" value="XM_016375478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNS3"/>
    <dbReference type="STRING" id="91928.A0A0D2BNS3"/>
    <dbReference type="GeneID" id="27328196"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01113"/>
    <dbReference type="HOGENOM" id="CLU_000288_26_2_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000535">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="79"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="584"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="263"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="352"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW20538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="874" mass="97212" checksum="B686C8DEF213BD98" modified="2015-04-29" version="1">MTSFYSAGQFMNPGPAPRPPTDRPRELQLQRSNSALPISSFDAMNLGPSSPAISTPSAPFFSNGSSISLAGSGKSSAANIIKEGHVRCKEDKFLAQWNQRYLILREYRLDFMKSETGKCMQSIQLNTVTGVTRSEETRMAFEITRIANPKDAGGKVVMTRDLPTRTITCEVRNDDEIYEWIDKIYERCPGMGGVSNPTNFSHRIHVGFDPQTGGFVGLPQEWEKLLNSSAITRDDYKKNPQAVIEVLQFVSDQKMRDQHPEIYTPGMVTPPATQPNKQVGYPTGGNSVAPPRPAPPTDAQRYNANQFMHKYQDSQSRSGTPPVKPQLQRSQTDKAAYDMEADAARIKEIANQEQKRRQMEAEAKRVREQERETAERERRELEAYNASLPKTRPPIAQQEIGGFGGSAQPNRQDPRFNPARAAPSAPQQSSSLRQQPVAHRPAPSAPTTSASQNSIPQSTSAGQASLRAPGSREPERQPSPNARYQAERDAPRKDVLPKPQANGVNGQSPSRSPGSVQQPKPLNVAKQPQAKPAADPRKEAEIALTAKKPVEERAKEVRMSSMSENEVMAKLKQVVSKDNPNDSYSKQKKIGQGASGSVYVARVRESATSAVAREVYRTHGPKGQVAIKQMDLRNQPRKELIVNEIIVMKDSKHPNIVNFLDSFLQEQNNELWVVMEFMEGGALTDIIDNNPVITEDQISTICFETCKGLAHLHSQDIIHRDIKSDNVLLDRVGNVKITDFGFCAKLTESKSKRATMVGTPYWMAPEVVKQKEYGPKVDIWSLGIMAIEMIESEPPYLNEEPLKALFLIATNGTPRLKNPNKLSRELKAFLSVCLCVDVRSRASADELLRNDFMRMGCSLASLSELLKWREKGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPW3</accession>
    <name>A0A0D2BPW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240751.1">
        <property type="nucleotide sequence ID" value="XM_016375475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPW3"/>
    <dbReference type="STRING" id="91928.A0A0D2BPW3"/>
    <dbReference type="GeneID" id="27328193"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01110"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="233" mass="24705" checksum="4F89A34D00918E06" modified="2015-04-29" version="1">MALDLAKRGAKVVITYTSASSEHQATELTSRINDHLPNSSRATSVRADMGDTASPRRIVETCVSTFGPRIHILVNNAGVSVTRPLSELTLQDYERVYGVNVRGAVLLTQAVLPYLAPRGRVVNVSSVGARAGFAGLSLYASSKAAVEGLTRSWAAELGANGTTVNAVAPGPVRSELLDTIPREIVQMQMDSTPVERRVGVPPEVSSVVAWLCGDEAAWVSGQVINVSGGWSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ64</accession>
    <name>A0A0D2BQ64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240856.1">
        <property type="nucleotide sequence ID" value="XM_016375580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ64"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ64"/>
    <dbReference type="GeneID" id="27328299"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01216"/>
    <dbReference type="HOGENOM" id="CLU_005610_1_0_1"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="181"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="649"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="738"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="971"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="738"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="971"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1136" mass="124456" checksum="0A82115FCA64E936" modified="2015-04-29" version="1">MLAIDNISGLGLKDTILSNMMEPELPQVNIPRVLLRPEDASRLGRPSRFDDSDRPPRASSEDTRSQAQRVEAGQIFETSPPKPEEAKASGQNKKSDLSLLSLEDTTELFKKKVADARQDTEHALAGSEAVRDVVKPKLTLDLGHSNIARLPESVVDLIKDEVERLSLSQNQIWHIPLRFSECTHLRYLNIRSNVFREIPRGVYKLNQLEILDISRNKVRKISPDIKNLRSLRVFSLVHNRVEELPTELCEMTKLQILKIAENPLRFRLKRVVEYKESEVSFSEMTDHERETAITLEIKRYLREAHSSTLAPIDVEASLQIDEGPMETPKPLKRTLSSRFPVIPSTGSGLSETGSEGNKSSPIQPHPPPVPTRSHFRMTSGTQSIALRRPGIAPLISQNSNERNRSNSESVLQASAAARHKRMGMLRREKPDLDSIDELKVNRNSHLRGFSHGSVLKRNGTLSSPGGASSSSPNSPRDSRRNRLAFVKRLSSLPEHKVENELNSPVIDGAKGILYALYQIHPHISGLIAAIRGKDPRRSTLEFTFFNASTHVDRLNEALEQAEVVDVEDEDAVQRVESTVRHDCATCIMAYTHVTAQLQDNVKKIVAGADVRYVRSLMLLLYGSMIEVRNAIQSFGADVNVTRGFGHRRQLSSGNSHPIQTIPEEFSTPSQPVRAITPTRDRNVPSRQGGRLRSDTAIQHPVAEPVATYPPNPVLPAPSGSLPTPIHLTGTTLNGGNLTGTSSTFSNSGTLNSNGLRSRSSSRAAMMNGMSSSVASTPRSGEAFNLPMANGYPARVNPATGLTDAQEEAIFEQIFLALSRAYDAALHTIPIAKAQFIRCLEAAEENRQPKSVHDLWSTLVYRCKLCIDVSEALQVRLVNMRLKEPSVPGTGRNDPSLWSLCKNFLMNFIELLTDMREAKSLRLLSQELIIMLRPVQKASREAGRLIETSPWRYLTDSASAAMPPPSVFNTLTSQQSAPATNGNGYTHANGVNGASVDGNSSVYSTVTSSLGHHAVQSQFPQPVVPVPPAPGTGPSSANTPNTAIMPKQMVNVNNVLGLPNGTNGISPVSVPLPATPLSAALGPAAQATVPNMNMQMAIPSTPASAYGDQFFRGDVFQRADSLLSMPQAGNVNFLNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQA5</accession>
    <name>A0A0D2BQA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241344.1">
        <property type="nucleotide sequence ID" value="XM_016376068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQA5"/>
    <dbReference type="STRING" id="91928.A0A0D2BQA5"/>
    <dbReference type="GeneID" id="27328791"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01708"/>
    <dbReference type="HOGENOM" id="CLU_063146_1_1_1"/>
    <dbReference type="OrthoDB" id="97518at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF161">
        <property type="entry name" value="TUBBY C 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="194" mass="21476" checksum="F46EC32D2908AA67" modified="2015-04-29" version="1">MESLAPFHPPLGINQAFCRPHEETLQMKEKILSLSGDDFEVTTVSGLHLCRCNGKVFSISGAKRFIDMQGNEIFTLKNKHIALHKSFYAVGPNGEEVFKVKGHFSVLSSKSTIHFQNQADGSQIELDLKGNWLNRSATITLAGRPVAHISRSFMNARQIFGGQQTYFVTVAPGVDLVLIAAICVCLDERESEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQL7</accession>
    <name>A0A0D2BQL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241499.1">
        <property type="nucleotide sequence ID" value="XM_016376223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQL7"/>
    <dbReference type="SMR" id="A0A0D2BQL7"/>
    <dbReference type="STRING" id="91928.A0A0D2BQL7"/>
    <dbReference type="GeneID" id="27328946"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01863"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000426">
        <property type="entry name" value="Aldehyde reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="349" mass="38374" checksum="D810D9200A4FAC53" modified="2015-04-29" version="1">MSSTADLAIPRGALVVVTGANGFIASHVVDQLLLAGYHVRGTVRNTKRADWMIEYFNTKYGAGKFDLVEVQQMADPGAFDNAVQGASGVIHLATPVMQSYDPNEAVPMVVQGALNALKAAAKEPLVRRVVMTSSSTAAASPVPNVEFVIDEKTWNDEAVKAAWAPPPYEGEQRKLDVYSATKTQSEQAAWKWVEENKPEFVLNAVLPNANIGVVLSPEHQGTPSTVGWVKAVWDGFKGQEQLAFNPPQYYVNVQDTARVHVGALIYPDVQSERLFAFAHPFNWNDILASFRKLYPEHHFIDDIPDLGRDLSRVANGRAEEIVKRFGRAGWTSLEESIRDATLGWAASEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQQ4</accession>
    <name>A0A0D2BQQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241021.1">
        <property type="nucleotide sequence ID" value="XM_016375745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQQ4"/>
    <dbReference type="STRING" id="91928.A0A0D2BQQ4"/>
    <dbReference type="GeneID" id="27328466"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01383"/>
    <dbReference type="HOGENOM" id="CLU_052691_0_0_1"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="451" mass="47878" checksum="76847DC9705002F0" modified="2015-04-29" version="1">MFDTICTLPLQSDLFAQVIHPSEPFFAVGLSSGHVQAYKLPSESHVIESASQDSSESASNNTDLINGHGSTSTPSLLRRSSSTSASESGLGSIDTVWSTKRHKGSCRCLSFSYDGEICYSAGTDGLVKSFVAETGKVVGKIAIPEISGMPELDEPSVLHALSPQALLLGTDSGKLYLQDLRQGGREIVSRASQTWEPHGGEHINTLVPLPASETSTSGFPKQWVTVGGSTLAVTDLRKGTIATSEDQEIELTSATLIQGLKKGGTSVGEKLLVGQGDGVVSLWEKGVWDDLDERIVIDRSGLSVESLAEVPFGYGKGKLKMNEKLVAAGLEDGRVRFLRIGRNGVMNEMDVKHDEIDGVVALGFDIEGRMLSGGGQTVKVWTEAKGLPGGGRASGTKHDLSSDDNEDGADEDDSDMGDSTDEESHPKGKRKKRKRGKGKDKSGGKALDFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQV8</accession>
    <name>A0A0D2BQV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ChrR-like cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233745.1">
        <property type="nucleotide sequence ID" value="XM_016383042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQV8"/>
    <dbReference type="GeneID" id="27335800"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08717"/>
    <dbReference type="HOGENOM" id="CLU_1855014_0_0_1"/>
    <dbReference type="OrthoDB" id="9970537at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15488" checksum="A85D0769FB157913" modified="2015-04-29" version="1">MPSLAKPEIEFTPVTDSKGVFSSSVTSHSNGDGTFTNYRTYLLSHDPTTGDRTILKEHSPGSVWGGNPSDNFDKDTVCSHDYWEECYIIEGRFYDVGKEQWFAAGSYCCRPPGMLHGPCRADEKVGCREICMARYEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRK0</accession>
    <name>A0A0D2BRK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241221.1">
        <property type="nucleotide sequence ID" value="XM_016375945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRK0"/>
    <dbReference type="STRING" id="91928.A0A0D2BRK0"/>
    <dbReference type="GeneID" id="27328667"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01584"/>
    <dbReference type="HOGENOM" id="CLU_075332_1_0_1"/>
    <dbReference type="OrthoDB" id="4590707at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239283" evidence="2">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="154" mass="16576" checksum="46D50AD99B84FA62" modified="2015-04-29" version="1">MVGFRLIGSTVFTVVAGGWLLQQGPSKSDHGHGHAEPKEEAQEAPEEEPKEEEEPKEELKAEEDATPKGRPAGEERDTTESAGDQQKQGDLSSASNPYMGEGDKSKKAEGTPESARVHGTVDSSRPIGGHKDPEKSQPSAPEKQSDKDEKESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BT10</accession>
    <name>A0A0D2BT10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_02115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241751.1">
        <property type="nucleotide sequence ID" value="XM_016376475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BT10"/>
    <dbReference type="GeneID" id="27329198"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02115"/>
    <dbReference type="HOGENOM" id="CLU_1081788_0_0_1"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW21535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28552" checksum="60E7F91A797D8150" modified="2015-04-29" version="1">MLLYEAPKACTSFFQEVQDAGEQLPQIRSEISYLQHNLSSLRFLSEADEDTINEAKATGIIQSMNECGVVCDKFTRQLTRWTSSGVDRIRGKLKFKLHGAQIAKARTRLWATARMLEMTIGILTLKLVAKSQSERATEKSLLQQAIHGWKRQAEKDQENVSASLRALGDSDDSGVIDELEDEEIVLKQFVETSSQTLEQIRAIKLNQTITYIKGDDSRFELGMPVTVVDKVAQQTITHVEGNKSVFRLGIFKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVK2</accession>
    <name>A0A0D2BVK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235530.1">
        <property type="nucleotide sequence ID" value="XM_016379703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVK2"/>
    <dbReference type="STRING" id="91928.A0A0D2BVK2"/>
    <dbReference type="GeneID" id="27332442"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05359"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="302" mass="33159" checksum="E2FBF46985A21B16" modified="2015-04-29" version="1">MSIFVVGATGIVGGAVARHLLSLNWAVHATTRNPDSKASKALQALGAKLFKGTWDDERALLTALAGCSTLFLNPYTYPFDQGEEVHWSNLILTTAKAAGVKQVVFTSIFGTQNPEKLKYQHPLVTKVQESKGKVEQLVRAAGFDFWTILRPGYFMASFLLPKAVLFAGFLETGRWTTALLPESPMPLIDEHDIAVFTAAALADKVRFNRKEIELSGELRNPEEITKALSGASGREIKAVYLTAEEVEAQEADPLVGAYLALRDMHLYVDIDQVKAWGLPIGTFEAYLARKNDVVQETYGLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVT0</accession>
    <name>A0A0D2BVT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235610.1">
        <property type="nucleotide sequence ID" value="XM_016379783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVT0"/>
    <dbReference type="STRING" id="91928.A0A0D2BVT0"/>
    <dbReference type="GeneID" id="27332523"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05440"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF9">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="486" mass="53991" checksum="503E4F7C96F71147" modified="2015-04-29" version="1">MGKETISVSGSDPNVESGSFAPVIDKAAEKSYVRKLDFYLLPFLSIMYFFNSVDRSNLGNAKTDGLDKDLNFTGNDYSLLILLFYVPFGLCDLPLNLLTKRFSGKVMLPSLMFGWGSLSLIQCAAKNFGGMLAIRLILAIFEAGFFAGVVFYMTLFYTRGELGFRIAVFFGSALLAAAFSGLISYGVFQIHHVSVKGWMWLFIIEGGMTVITAVIAFWWLPARPDTAWFLNDAEKIAARNRHLRDASRTVNTEFDLRACFATWKNPKFALWVVIAFTYPVAFATVSNFLPQIVQRLGYSVVKTNLWTVAPNSVGFVVLLCVTKSSDYFRERTYHIVFALSLSLVGMIILAAIDVLENKGVAYFACFLMASGAYIPSCLVHSWHNNNNLEENSRAATTGLLVGLGNLGGIISAATFRVEYAPGYVPTLIATSCCNVTCIVFTLVLGLYMKRENARRNKEQGVIMRAEDVDTDTLQDGEKSPNWRYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWZ3</accession>
    <name>A0A0D2BWZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236040.1">
        <property type="nucleotide sequence ID" value="XM_016380213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWZ3"/>
    <dbReference type="STRING" id="91928.A0A0D2BWZ3"/>
    <dbReference type="GeneID" id="27332957"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05874"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_1_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="190"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="354" mass="39735" checksum="64BC880535665AF3" modified="2015-04-29" version="1">MDYSSTSVSKGVDDDDLVIPVINFQNFLQGDRNTRVEAARAILDAFRNSGFIYLSNHGVSDEMVNDCFSHVAHFFARPQDQKDSLAWTDARTNRGYVKAGREKLNLSGQASDELRNQTPDLKETMEIGWDGNTSKPNKWPERLDDEGVEFSRFMRVFYDRMHDLNLQIMSAIALGMGLDEAFFTPFVDAKDNNLRILHYPSVRETGRTDKIRIRAGAHSDYGSITLLLQDSIGGLEVQSPRGTWVRAKPIPGTIVVNAGDLLSRWSNDLIKSTKHRVVQPPPKPDGSSSSSSQEPETGSETILPERYSVAYFCIPNFDALIDALPGTWELDPVGKKYPSILSGEYQYQRLSETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BYU3</accession>
    <name>A0A0D2BYU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Guanine nucleotide-binding protein alpha-3 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_06528</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236690.1">
        <property type="nucleotide sequence ID" value="XM_016380863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BYU3"/>
    <dbReference type="STRING" id="91928.A0A0D2BYU3"/>
    <dbReference type="GeneID" id="27333611"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06528"/>
    <dbReference type="HOGENOM" id="CLU_014184_0_1_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="155"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="180"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="205"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW16474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="357" mass="41122" checksum="5965CDE2AAF8A401" modified="2015-04-29" version="1">MGACGSKEASNEDSEQKKRSQAIDKKLEEDSRRLRRECKILLLGSGESGKSTIVKQMKIIHQNGYTQEERTLYRLTIYKNLVDCMKALVSAMQQFEIEPEDQTVKDYVEYIMEYNVDPDPDTPLDPKAADAVEAIWKDPAASKTMDRQSEFYLMDSAPYFFEEVRRLAAPDYIPNEADVLRARTKTTGIYETRFTMGQLSIHMFDVGGQRSERKKWIHCFENVTSIIFCVALSEYDQVLLEEANQNRMMESLVLFDSVVNSRWFMRTSIVLFLNKVDLFKEKLGRSPLGNYFPDYSGGNDVNRAAKYLLWRFNQVNRAQLNLYPHLTQATDTTNIRLVFAAVKETILQNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BYW0</accession>
    <name>A0A0D2BYW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236705.1">
        <property type="nucleotide sequence ID" value="XM_016380878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BYW0"/>
    <dbReference type="STRING" id="91928.A0A0D2BYW0"/>
    <dbReference type="GeneID" id="27333627"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06544"/>
    <dbReference type="HOGENOM" id="CLU_022340_2_1_1"/>
    <dbReference type="OrthoDB" id="5420391at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PPK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084">
        <property type="entry name" value="YALI0E26631P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="448" mass="49260" checksum="3C440D0083EF0C18" modified="2015-04-29" version="1">MSADLFAAFVTADDNHGEVGDAIQPPLGKVEQDLDGHDFSVRNVTTPGGTAPGLQATPLWKRDVGGNDVLFDAEDEPNVEDDDFGDFEIANASEGTAPHNQLHHTSHESVSLGRLIPDLLDDGNHRKLSFSGPPTASTIVTNPGAINQTNLPPTKLETRSEGSQDQGTSEGWSEFEDAQNVDDVRTPEEPFKKPEDKPFPSQGTTVNDEDEWEPFEDGQTDMPPQPPPSVEPEIASTGSRPISTFQAAIPSFERPTNVPPPSSLLQLMSTVFDQLHQANVTNNISKPALATKVLLVYRTASRLAAGRSLRWKRDALLSQSMKIGQAGARGGMKLASVDKGEAAKESRDLEEMIHDWMKNIHEYNSIIAHAGLPPQRLKMSAAPNLRIQKSWGSSDIKQCALCGLKRTERLVDVDVDTDDLFGEFWTEHWGHKDCYEFWYSYKGLLAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZ61</accession>
    <name>A0A0D2BZ61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-aminobutyrate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236805.1">
        <property type="nucleotide sequence ID" value="XM_016378128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZ61"/>
    <dbReference type="STRING" id="91928.A0A0D2BZ61"/>
    <dbReference type="GeneID" id="27330860"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03777"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000013">
        <property type="entry name" value="4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="433" mass="46826" checksum="54ED7B865485F124" modified="2015-04-29" version="1">MSLSKLAEFGTRHVARGIGRLATEVIESGSGSYVTMASGRKMLDFTCGIGVANLGHCHPAVTKAAQAQVGKMVHAQVNIAFQRPYLELIQSLIPLMPHKSLDTFFFWNSGSEAVEAAVKLARHATKKQNIIVMQGSYHGRTFGTMAMTRSKTIYGENYAPLMPGVFATPFPYCAQCSIASRCDGKYSAENCCMDPVDQLELLLKRETAPSDTAAIVIEPVLGEGGYVPVVPEYLKRVREICDKNNILLVVDEVQSGFGRTGKMFAIEHYGVRPDILVMAKGIANGFPLSGIVSRKELMDTQKPGSMGGTYAGNAVSCAAGIAVAQAFKDEKILDNVAVRGEEMVGMLRQAKADFPDLVYDVRGLGLMLACEFVGGKGYASKVQAKCMEKDLLILTTSIYDTLRFIPPLNISKEDMAKGLSIIRAAIEEVAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0G3</accession>
    <name>A0A0D2C0G3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237330.1">
        <property type="nucleotide sequence ID" value="XM_016378653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0G3"/>
    <dbReference type="STRING" id="91928.A0A0D2C0G3"/>
    <dbReference type="GeneID" id="27331388"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04305"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000068">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="165"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="389" mass="43397" checksum="F95346D22D6396F7" modified="2015-04-29" version="1">MALDNFYHNKIESLKLEIIQGQAVLRRLEAQRNDYNSRVRLLREELGLLQQPGSYVGEVVKVMGTKKVLVKVHPEGKYVVDIADNVDISKLTVGKRVSLLSDSYKLEKMLPSSVDPLVSLMMVEKVPDSTYDMIGGLDQQIKEIKEVIELGLNHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHSNCKFIRVSGSELVQKYIGEGSRMVRELFVMAREQAPSIIFMDEIDSIGSSRVEGSSGGDSEVQRTMLELLNQLDGFEPTKNIKVIMATNRLDILDPALLRPGRIDRKIEFPPPTVEARADILRIHSRSMNLTRGIDLKKIAEKMNGCSGAELKGVCTEAGMFALRERRIHVTQEDFDLATAKVLNKHDDKEVSLGKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C2C3</accession>
    <name>A0A0D2C2C3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="10" type="ORF">PV08_04994</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238015.1">
        <property type="nucleotide sequence ID" value="XM_016379338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C2C3"/>
    <dbReference type="STRING" id="91928.A0A0D2C2C3"/>
    <dbReference type="GeneID" id="27332077"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04994"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_0_1"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="359"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW17799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="459" mass="49768" checksum="DB3C18297610B7D7" modified="2015-04-29" version="1">MTSTPATSGNVSVRARLTTRDTDLALQESAPILIPTSFRRIQLSTLVNNLVKTEKTIPLDFIINGTYLRTTIDEYLTNNGISTETTLNIEYVRARIPPQYAASFEHDDWVSDVDVLSGNNSRILSASYDGLLRVWNASSQVLATSPAMSQSGQAFIKSAKFISPKQIVSGGFDRALRLWKYEEEQDGFSAHITPQLELYGHKGSVDSVCPHAESGRILSGSSDHSVGIWSTRTSDAPAAPEELVPKSKGKDGKRRKLNPEISVPNRGPVALMKEHTGQVSGVTFDSNDHTVGYSTSWDQTVRTWDLVTASLVDTRTTSGALFCIEHMPSLTLIAAGSVSRVIKMVDPRASAATVTAMTLKGHKNSVVSLARDPGNEYTIVSGSHDGTCRVWDVRSTRQEKEGSVVSSLYTLPRASQKGSPASAVGEGVKVFAVCWDKHLGILSAGEDKAVQINRSDERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C5N4</accession>
    <name>A0A0D2C5N4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239095.1">
        <property type="nucleotide sequence ID" value="XM_016377525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C5N4"/>
    <dbReference type="STRING" id="91928.A0A0D2C5N4"/>
    <dbReference type="GeneID" id="27330251"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03168"/>
    <dbReference type="HOGENOM" id="CLU_011099_2_1_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="205"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="620" mass="69089" checksum="058658141777C64F" modified="2015-04-29" version="1">MEALLQSGLSNKARPPPADHFATPAARPTMTALEKDMSNLVVGDTGEQKYIGKPSTRFHHEDGSSHACHVMARAFVWVQRVFPAFTSLGFFSTFNKIYPLFRRDTFQVLFDRQYSAESHQQGSSFAALNIVLAIGCYMTPESSRANIQMVDPSSTESLTDMSWRFFQNAYSMFFNILFLQFDLLSVQTLIAMAFFLQATFNGEGSFLLVGAAARIATSLGLHRKLDGFGLGQAELEQRQRVFWILYVFEKDFCMRIGRPSAIDDCDVGLSLPTEPCDEEIAVSIASRGETVTFYPFRHMCAFAVIQSKVYRELYAVHSRIGTTSERLESISKLDAELQRWKEQIPLDARPEHPIVCEKGSEFAIVILHINYYHCLIGIHRVHAQHELWVAQQAEVEGFDKTTPDSSMLSDQEQSAPQQQSSYELVLAAARSILYLAASHLDGNEMEHKLLWLPTYFPMMAFLTLFMHILQRPLSERSDSDLAIMASCYGCLRSIMSKEEALLCQFAETILGETLSSAEQYVQEARARDLEFAGRSAFQPPAPAQFETSATTPADGVMGRNLGGSESYPTGFAVTEPAFNPLQNMDTSNPGGSNMMNPMANPGDNYMNAFAGQDDLLASVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6H0</accession>
    <name>A0A0D2C6H0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239385.1">
        <property type="nucleotide sequence ID" value="XM_016377815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6H0"/>
    <dbReference type="GeneID" id="27330545"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03462"/>
    <dbReference type="HOGENOM" id="CLU_1660781_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="159" mass="17830" checksum="9DB16B0EE6778AA4" modified="2015-04-29" version="1">MPLGRSSQAGWLCKLCLAVQGNGLRADNKPICKQMPKPASRAARAWMLVQEHEMDPDVAMVQITLERGQDYIRLAEEYIRVTMGQPCSRLGWRYAKLESPHMSVEDGSRKTPRQRHDSRRLTAKAVAKKALRSVRSAKGTTRAPRKGDEETGKFAPDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C701</accession>
    <name>A0A0D2C701_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_03649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239570.1">
        <property type="nucleotide sequence ID" value="XM_016378000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C701"/>
    <dbReference type="STRING" id="91928.A0A0D2C701"/>
    <dbReference type="GeneID" id="27330732"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03649"/>
    <dbReference type="HOGENOM" id="CLU_010348_2_1_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000003">
        <property type="entry name" value="Deoxyribodipyrimidine photo-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="100"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="352"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="396"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="494"/>
            <end position="496"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="597" mass="68706" checksum="0B1EC0B6C46307A2" modified="2015-04-29" version="1">MPPDFKRHRRADSGSGPAPVAAARLEKRPRTSQTDHPSPRYKDSANEVKYGIVLRKYYPPEMTNDRAREYIAGSIERPIETLNKAVQETQTERDKIPVNKCVVHWFKCDTRTSDNKALHLASEKAKTHRIPLICLYLVSPQDFEAHLTAPVRVDFILRNLQALKDDLAELDIPLYVETVNKRRALPSRLMQLCDGWGARHVFCNMEYEVDELRRDASLVRSCLDRGISFNVVHDTCVVEPGKLSTAAGGQMSVYSPWHRKWCAYLNQHPHELECYAPPTQNPANTRAKYGELFTCQIPEAPASKSLSEEEKGRYRALWPAGEREAQERLRRFIQDRVGSYHDTRNIPSGNGTSILSPHLAAGTIAARTVVREARDAAPNKKLTDDRKQGHSMWIGEVAWRDFYKHVLCHWPYICMNKPFKPEYSNIEWEYDLEQFQRWTEGKTGFPIIDAGMRQVQHMAYMHNRCRMIVASFLAKDLLIDWRMGEKWFMEHLLDGDFASNNGGWGFSASCGVDPQPYFRIFNPLLQSEKFDPQGDYIRRWVPELAEIKDNKGIHDPYNRGYEKVAKANGYPRPMVDHKTSRERALARYKQGIGRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C7C1</accession>
    <name>A0A0D2C7C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_00026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239670.1">
        <property type="nucleotide sequence ID" value="XM_016374394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C7C1"/>
    <dbReference type="GeneID" id="27327109"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00026"/>
    <dbReference type="HOGENOM" id="CLU_577509_0_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53277" checksum="7671F1FA83CF0922" modified="2015-04-29" version="1">MNLRLKDKKSPIVEQVCSGTSGSTEENPIDAVIIGAGPSGMVALRQLLRDDPPLSVMAIDRQKGPGGIWTGHIPAYSTLQDLKCEYEVHGVKFPQQEPQRRAPRDQVAEFCEAYHNEFGLKEHVLWQHDVTSVEMVKPMLHQVKVEPFVEGLAEAVTTTIYTRSVLVCTGHNIHKYVPQLPGQETATFPIKHNNEIREPSELPTSDIIVIGAGPSAMDMVQEACITQKATNVHVVARIAHWGAPDMWWPWMWQFGWSELHLLRVLYRILPIYVVDALLYYLNLIWAIVHGIPEWRPPVRDPVSSKVAYILRTHLLPPYRNGQFKIHNDCRIKLIDGDKVTLTDGTVIYPKMIVAATGWSTDSSFLPGGTKAGEYDSLAAADIPKPFYLRFYDQEHPGIFYISMANGFMAYTENASFLAQAVNQILRGTWTPPSAKEMEKNCREVVLHHIGLPGRLQTDLEEAGFKDLRTKNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C7R6</accession>
    <name>A0A0D2C7R6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="3" type="ORF">PV08_00177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239820.1">
        <property type="nucleotide sequence ID" value="XM_016374544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C7R6"/>
    <dbReference type="STRING" id="91928.A0A0D2C7R6"/>
    <dbReference type="GeneID" id="27327260"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00177"/>
    <dbReference type="HOGENOM" id="CLU_079430_0_1_1"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="211" mass="22879" checksum="F7CD9D4016047FC6" modified="2015-04-29" version="1">MSSVSASRLLLPSIERSLCSRCMYRHTTTTTTSSLRWNSSAAAPSSPLLAKLKQDLKAAMRAKDQARLTVIRGTISEINQAASSSTPITTDMQILALLRKRRSSSETAKQEAIDAKRPEFLEKLDLEIAVVDELMGTVSMMDVAEMRSIVRATVESIRGGQQGGGEGGELKPGPVMKELLRPGGPLQGKPLDNKVLAEVVREECFSNHGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C7V0</accession>
    <name>A0A0D2C7V0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239870.1">
        <property type="nucleotide sequence ID" value="XM_016374594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C7V0"/>
    <dbReference type="GeneID" id="27327311"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00228"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="548" mass="59316" checksum="9E30C0F063DF0B61" modified="2015-04-29" version="1">MAKKEHEIHDQTNLLTGSRLIITFCALASALLVTYIDQNSIGVVLPTVGRDLNSASTIVWAGTSSLIANTSFQVLYGRLSDILGRKVILLTCLCLLALGDLLCGFAQTGPQLYAFRGISGLANGGIMALVMMVVSDVTTLEQRGKYQGILGSCVGLGNTIGPFVAAAFTRNATWRATFYFIAPLAVCIAAMLYFVLPPQSIPQEPLSVKLRKIDWIGIVLSSAGAMLLLIPISGIGVQFDSKSPMVISMLTLGSVFMTAFVLNEWKLARLPMFPLRLFKNPALGAMLTQNFLIGIVFYSLLYYLPIYYQSARQMSLITSAAMIIPIVIPQAIASALSGQYISRRKRYGEVLWTGYICWVIGTALHCIFSRTLSVVAIVFILIVEGVGVGLVFQPTLVAAQAHAPKQDRAVVISARNYIRALGGSGGLAIASAIFSNSLLSSLPNDLPQNITRQIQDSIFDMPLLDGLSVEQQNQVKDAYVNAARSVFYLWAGAMACCLCLMVFIKDKGLTRQEEKAPPRSAEAINTDAPSRFPEPEMTSTVQETKSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8B7</accession>
    <name>A0A0D2C8B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240030.1">
        <property type="nucleotide sequence ID" value="XM_016374754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C8B7"/>
    <dbReference type="STRING" id="91928.A0A0D2C8B7"/>
    <dbReference type="GeneID" id="27327472"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00389"/>
    <dbReference type="HOGENOM" id="CLU_005210_0_0_1"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="389"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="487" mass="52154" checksum="FD32B2C77E97CD3F" modified="2015-04-29" version="1">MTLVFALGSNGYGQLGTGHREDSAAAQRCLFEGPPQVEETPCSSGRSDGDGDADTTTSIESGTGNRSGTGTENDDATTTTVTMQVKKIVAGGNHTLLLTLDGRIFAAGKPVGEFERDSDEEEQEEDQGQPTPPPPSPPPRPRQPSTRTPSTVFRECRTDFLAGATTETQTEAEATGPKRNTKCYISDVAATWDASFFVVDRKSVYVLGTGSKGELGLDHDVHETRRPRKVFDVGHQDDDDGNGSISFTTVEAATTTITTTAAEADILTIAASMSHVVVLLSDGRCFGWGACRKGQLGDKFRVDKALWRPTRIDKKDSSSLLPFRPDGVVLGREYTAFFRCGKPLLVWGERKDFLHEGQQALNHTLHKGDIVVSGWSSLHILSCSPSSSPTVMSSGKNHRGQLAPDKLPSITALAAGSEHCVAVTTTQDVIAWGWSEHGNCGAEVDRKGNVAGRWNVISLPPLSSKYRVTAVAGGCATTFVICEKTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8I0</accession>
    <name>A0A0D2C8I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240075.1">
        <property type="nucleotide sequence ID" value="XM_016374799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C8I0"/>
    <dbReference type="GeneID" id="27327517"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00434"/>
    <dbReference type="HOGENOM" id="CLU_030884_1_2_1"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55778" checksum="160C784EFE9F718E" modified="2015-04-29" version="1">MSQTSTMAADLDPEHQHAVVVPKKQRTLFGFKVPRYSDPMVQIVVVGFILFLNPGMYNALAGLGGAGQVDPTAQNNAGIALHTTFAVIGFVVGIAHNFLGTKWTMAIGGIGYCVYSAAFLCYNHTRNEGFVIFSGALLGFCAAFLWCAQGVVMMSYPVESQRGRAISITWLLFNLGAVIGAAVSLGQNWSVKAGHVTDGTYVGFIVLEASGALLCCFLTPSEKIIRKDGTKVQKVIHPGLKSDILGLYTTLVTDPWVILLFPMFFASNYFYTYQFNDVNAYFFSTRTRAFNNIFYWISQIIAAAAFGAFLDWTRFSRRTRTLVAWAILFTLVMAVWGGGYKFLLLTHRHVKGPGMDLFDKDYTWYLLLYMSYGMLDSLWQVFCYYTMGAMSNDPRRLAYYTGFYKSIQAVGATAISKLDADKVSFHINFGTSWGLMAGGLVIAFPLYWFRLHNTEVDEEDFIGVPTGKEVHKSTVTDVAAKGEGSATVSEKKAPDDHHELDKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C9M8</accession>
    <name>A0A0D2C9M8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_00864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240505.1">
        <property type="nucleotide sequence ID" value="XM_016375229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C9M8"/>
    <dbReference type="STRING" id="91928.A0A0D2C9M8"/>
    <dbReference type="GeneID" id="27327947"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00864"/>
    <dbReference type="HOGENOM" id="CLU_748130_0_0_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="167"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="331" mass="36016" checksum="2A07045F3306068F" modified="2015-04-29" version="1">MDEPDFLAPPPAGPPPLLSDQQLIILARQGWLCVDLPDSLSRSLQDVFESSLEFFNDPSQPKAELYPKKLGTEFGYYPVANEKEYLTFRCHVHGGSNASSASSASEALAVASAVALEAKVAQAWREAALYLFRILCDISRASDLDLSVWNDILDGTLTMPNSEQDMTHTLMRLFRYFPTTGFAGQHSDLGLLTLCVGNGEGLQALDRFQSTTDIPAWVNAPVGSGKGMVLIGETLKALSSNTVNTGAHRVVGNPHGRSSVVFALRHSTRHDIDFGLFGGEGVMSPKELWKSVQVGKININSTKEIREKQRAKLYADRSKSEVSDTLTTGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CB94</accession>
    <name>A0A0D2CB94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_01402</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241040.1">
        <property type="nucleotide sequence ID" value="XM_016375764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CB94"/>
    <dbReference type="STRING" id="91928.A0A0D2CB94"/>
    <dbReference type="GeneID" id="27328485"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01402"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="80"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW20824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="587" mass="63968" checksum="AF4B90F5D94929D6" modified="2015-04-29" version="1">MDVDLEKKESPSSDGGERPSQDYGQVVTRTQGPFWVRFIDGFRQNPNARVSEQLVDADGKLLPDQPTAQPALATKLKQRHLQMIAIGGSIGTGLFIGSGSALSTGGPAGIVISYCTLGIMLFCTVHALGEMAVMFPVAGSFSAYSSRFLDPAWGFAMGWNYAMQWLVTLPIEIMAASMTLNYWSGARDVNPSAWVSIFFVVIIAINFFGVRGYGEAEFVFSIVKVIAILGFIIFALVVDVGGGPTGHYFGAKTWDNPGAFANGFKGVGSVFVTSAFSFGGTELVGLAAAESANPRLALPTAIKQVFWRVVLFYIISLTFVGLLVPWDDPRLLNSGSTSNTWTSPFVLAIKNAGVGGLPSVFNAVILIAVLSVGNASVYGASRTLAALADHGQAPQILGYIDREGRPLVAIIVSSSLGALCYIVNLKPSQRQEAWNWMFAVSGLASIFTWGSICLCHIRFRQAWKHHGHSVDELPFKSQAGVLGSWLGLVINCLVLVTQFWTGFAPVGFREMSGSDRTKNFFEVYLAAPVVIVFYLGFKIWRKTSIRRVANIDVVSGRREIDLEQILADERATQATWPWWKKTWRFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y6W7</accession>
    <name>A0A0D1Y6W7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine-protein kinase ATG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_11585</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230837.1">
        <property type="nucleotide sequence ID" value="XM_016385893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y6W7"/>
    <dbReference type="STRING" id="91928.A0A0D1Y6W7"/>
    <dbReference type="GeneID" id="27338668"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11585"/>
    <dbReference type="HOGENOM" id="CLU_000288_172_3_1"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000549">
        <property type="entry name" value="Protein serine/threonine kinase (Ran1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW10621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="419" mass="45894" checksum="7BF135028EBA14DA" modified="2015-04-29" version="1">MLPTPPSSPELTTSCAPEDRLGCVLAGRLELVSVLGVGAYGVVYRAVDILTNVPYAVKALPKSGLDARQRRFQRREIALHHRASQHPNVVSLLRILDSPDCTFVVIEFCPEGDLFSNITEHGHFVGDDQLVKHTFLQVLDAVQYCHSVGIYHRDLKPENILVTNNGSTVKLADFGLATTDAVTSDFGCGSTFYMSPECQQAPSRPYARYAAAPNDVWSLGVILVNLTCGRNPWKKASPEDSTFRAFLQDPHFLSSILPISVELNMILRRIFECDPHKRISLQELRELIINCPRLTINSYNTLPPSPPASPYAYVDSMDCANLALPPSPPASPSPPAPFHTQPSEWSLFGPTSKSGSSCSSVSTDSGYESETVFNEAGLHLQPAPVFNFYGNVIPLNDDEKPTTYHPYSPPGYGPSVATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7L8</accession>
    <name>A0A0D1Y7L8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthase activator (Chs3)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231127.1">
        <property type="nucleotide sequence ID" value="XM_016384525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7L8"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7L8"/>
    <dbReference type="GeneID" id="27337293"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10210"/>
    <dbReference type="HOGENOM" id="CLU_008036_1_0_1"/>
    <dbReference type="OrthoDB" id="4095816at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="87910" checksum="1F6D4CB2F85CC636" modified="2015-04-29" version="1">MSYNTGATFVPGGDDSYYMPELAQPTPNRYADQNPSSGPSLNGSRAYELPTNMQHNVAQMEHVASSPNSSAYSGSVYTPQSAEYAPANMNAWSSAVPPSDYHNGYDQRAPSHNPPQSFQQNNYPPRTTSTAQIEQPNFSPFPVLRNPPPNIPPTDEQKEATLEAARAAVLSCNDPDTQLTWAQDALAYVEICQQNEERVALAQTPRSRTPRIEHMLREDALKITNFLADQHHPKAEFMRGMWLEFGKFGHRIDKKEAFLCYSRAAERGYVRADYRIGMQFESSNDALKAIKYYQKGADASDSASCYRLGMMTLLGQHGQPQDYERGLQLIYLAAQTADENAPQGAFVFGMLQAHQMTQVQVPERYLPKDISAAKINIEKAAYLGFAKAQVKMGQAYELGELGCPFDPALSLHYNALAARQGEPEAELAISKWFLCGHEGLFEKNEEMAFTYAQRAALAGFPTAQFAMGYYYEVGIYVPVNFEQAKEWYRKASQSGNQDANGRIDAISRSKTLSRKDHESVALSKIRQQRGSMIGRPQMPMLAEERLDMPDPSRLSLENRKPSPGRPGSTAPYPTGPSNLPHVPDFRPTSGFGSNPNIRPSSTAPLGGLRPDPYGQPHLSPQTRPYSSNDTRVPGPGYGRGDRIPSGPAPSRPGPPPQRPGTASPHIGAQAPPKLDIGYSAPLEQRRPQQPPQPNGYGRPQPPGPGPHGPPRPSPRPGQAPPQSQGPPQNRPAPQNARPGYGNPPQNIRPANMPPSKPAANAPSGNAPPSKPNQVSANAARPPGKGPKTFDEMGVPAGKDKGECIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y9A4</accession>
    <name>A0A0D1Y9A4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_10842</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231757.1">
        <property type="nucleotide sequence ID" value="XM_016385155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y9A4"/>
    <dbReference type="STRING" id="91928.A0A0D1Y9A4"/>
    <dbReference type="GeneID" id="27337925"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10842"/>
    <dbReference type="HOGENOM" id="CLU_004760_3_1_1"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="683"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="857"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="895"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="190"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="111"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW11541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="927" mass="105763" checksum="6914848A03C47055" modified="2015-04-29" version="1">MAYNRLGSPQRDGPYSPSANPQYDSRSPSPGRPLQPYAHPEESYSRQLQPLHLQMPTASNDRLAIQPTYSVENVHNSHGHNQQYDQQYPAAGDMGYGRNDYIVSPEEHHDAYYNQPYSPHPQGDYALDPYPTPGEPYRSDHDTAPILQPDSAYGPDPHSQPGMDYDGYHDEPRHDEPRPTPSPAPIRRWKTVKEVQLFNGNLVLDCPLPPKFLAQVPHAQPPERDEFTHMRYSAATCDPADFYKERFTLRQRLFAKPRQTELFIVVTMYNEDEFLFARTMIGVFKNIEYMCSRTSSKTWGKEAWKKIVVCIVSDGRAKINPRTRAVLAGLGVYQDGIAKQQVNGKDVTAHIYEYTTQVGLELKGTQVSLKPRSATPVQLLFCLKEKNQKKINSHRWFFQAFGRVLDPNICVLIDAGTKPGKDSIYQLWKAFDLEPMCGGACGEIKVMLDHGKKLYNPLIATQNFEYKMSNILDKPLESAFGFISVLPGAFSAYRYVALQNDKNGEGPLEKYFKGEFMHAEAGVFTANMYLAEDRILCFELVSKRNCRWILQYVKSATGETDVPDKIPEFVLQRRRWLNGSFFAAVYAVAHVYQLWRSDHSAIRKFMFLIEFTYQTINMLFAWFAIGNFFLVFRLLTSSLGSPGPLGRAGTILGVVFEFVYLGTLLYCFILSMGNRPTGSKKSYLMMVIFWSLLMCWLTFASIFLTVRSIQNEVQQKDFSFSTIFNNSTFFGLIVSLASTYVLWFVASFLFFDPWHMFTCFIQYLVLTPTYINVLNIYAFCNTHDITWGTKGDDKAEKLESVTIKADGKLDVAIPQDDGDLNAQYDAELQKFATKPPKEVKKENPADKQEDYYKSFRSNVVTAWMVTNFILVAAVLNTAGFDRINTNDTEQQNSTIYLAVILWSVAGLSLFRFIGACWFLIVRLFRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y9Y9</accession>
    <name>A0A0D1Y9Y9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231992.1">
        <property type="nucleotide sequence ID" value="XM_016383369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y9Y9"/>
    <dbReference type="GeneID" id="27336131"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09048"/>
    <dbReference type="HOGENOM" id="CLU_625602_0_0_1"/>
    <dbReference type="OrthoDB" id="4118146at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="423" mass="47384" checksum="58214A42F9365F10" modified="2015-04-29" version="1">MAHNMDQPSPFRYHAFFSQPRPDQGALSATDDEDVHMNDMPQTINPYQMDLTPPVVWTDEIPHSILSIAQGPLVQPNAINTQHSLLPHPIYYQNMITTPGMPEMQFYPHSPIQHPILNGNFAGTQAIRTPTMEHLLPLQPPASLMHPSQNALARRTIMPMPPAQQLQAQGQQQQTAAPGHRLDNLPAEIRLEIYGYLFQGAEIEVIPRNMTRCRPDVPASPCKVIEGAHTNIIRTSKFFFLDALPTLAKATHLNIPQPYHPQEATEDPLRQFPESFLKRIETITGDFNAFGRINGQRLRRLKHANLFHEVDSAGGFVDTVHIINCENCGGVDAVINAAFEGVVNNWRWLQKQIARNARREGFTVDMTVTWEVYCEAPGMAKFEFKMNCATNKVVRTKAFIGGQEVGTNSETQAAADWDALSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCP2</accession>
    <name>A0A0D1YCP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232922.1">
        <property type="nucleotide sequence ID" value="XM_016384299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCP2"/>
    <dbReference type="STRING" id="91928.A0A0D1YCP2"/>
    <dbReference type="GeneID" id="27337067"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09984"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33335" checksum="572DA243ECF8542D" modified="2015-04-29" version="1">MSFSESSVPDLTGKIMIVTGGNSGIGKQLVAVLASKGAKVYLGARSQAKYDQALQEIHTSHPATKKSSIEFLKFDLSSAAMAKRSAEHFKSKETELHVLFDNAGVMGTPAGKLSADSYEYQWAVNVFGTFVFTYHLLPLLQRTAEKSLPGTVRIVITTSDGAKQAPKSGIPLDDPTVGSNATRFQCYGHGKLGLILLTRQLAQRYPDILTLGPHPGPVQSNLTRELNFPGPVKWLLNRVVFKPVEYGALTPLFAGTASIPMSKTGSYLIPLAKFETNLPHKQCYDDKFGTRVWEWNMTAMKKAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCU9</accession>
    <name>A0A0D1YCU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Kynureninase</fullName>
            <ecNumber evidence="5 6">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BNA5</name>
        <name evidence="9" type="ORF">PV08_07968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="5 6"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232997.1">
        <property type="nucleotide sequence ID" value="XM_016382294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCU9"/>
    <dbReference type="STRING" id="91928.A0A0D1YCU9"/>
    <dbReference type="GeneID" id="27335051"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07968"/>
    <dbReference type="HOGENOM" id="CLU_003433_4_0_1"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF2">
        <property type="entry name" value="KYNURENINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="8">
        <location>
            <begin position="220"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="183"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="495" mass="54278" checksum="F036CAF1ACACED69" modified="2015-04-29" version="1">MAPEIITNGTDEQCSRSPAGKSIADFPSNANNIEYARSLDACCPLRHFRNEFIIPSKSNLRAQSLSEISASPMTDSASDAGIYFCGNSLGLQPKRTSAYVQNLLSTWATICVDGHFRPVADSPLAPWQDLAESASKLCAPLVGAVPSEVSIQNTLSVNLHLMMASFYRPTAVRNKVLLEFHAFPSDHYTIESQIKWHGYDPDEAMLLVTPDHGKYTLSTSELLATIDAYADQLALIVLPGIQYYTGQMLDIPLITEHAHKHGIPIGWDLAHAAGNVPLQLHDWGVDFAVWCTYKYLNSGPGSIGGLFVHERHGKVEYADSKSETGHDTESANRPIYRERLTGWYGGDRAVRFNMDNKFIPIPGAAGYQISNPSAIDLSCVIASLSIFNETSMQALREKSLRLTAYAEHLLLQDVPLIDGETAYKIITPCNPNERGAQLSLLFKPGLLDKVGQGLKSGGVVADQRKPAVCRIPPAPLYNTYEEVYTVVRIIKEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDA8</accession>
    <name>A0A0D1YDA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233157.1">
        <property type="nucleotide sequence ID" value="XM_016382454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDA8"/>
    <dbReference type="STRING" id="91928.A0A0D1YDA8"/>
    <dbReference type="GeneID" id="27335211"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08128"/>
    <dbReference type="HOGENOM" id="CLU_1008831_0_0_1"/>
    <dbReference type="OrthoDB" id="5375558at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="277" mass="30310" checksum="1AA699CDAE954348" modified="2015-04-29" version="1">MEDVVHPPSARRSIESICTIAGTKVPSIPPIPPDSVPNLESIRKVYDLAFAPGLDKFLESGPSKWFAREGFALLSSDRSQLGRMLAYLTLVSNHPEASGENPTLASQEARVTWALLELCIRPEHDGGEEADRLARRCRAMTSILTGEAFSSPTTSIADFVHQDEAEPEAKGNALERQVANRSDEFWRLVETAATSQGPNGEGISRAAVQQCRRLLDGMENRDIIYSIMLLGSKTNGNGDLTSERELAKRYLESQANGRATNQVFATISGMALRAYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIA7</accession>
    <name>A0A0D1YIA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Crh-like protein</fullName>
            <ecNumber evidence="18">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PV08_07455</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="18"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234887.1">
        <property type="nucleotide sequence ID" value="XM_016381785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIA7"/>
    <dbReference type="STRING" id="91928.A0A0D1YIA7"/>
    <dbReference type="GeneID" id="27334538"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07455"/>
    <dbReference type="HOGENOM" id="CLU_027506_2_0_1"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237103" description="Crh-like protein" evidence="22">
        <location>
            <begin position="25"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="23">
        <location>
            <begin position="14"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="270"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="305"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="19">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="19">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="30"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KIW14671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="490" mass="50484" checksum="F15E1CFAF9A7B989" modified="2015-04-29" version="1">MHSSLLGSVLTALAISSLLPTATAQTYTSCNPLEQSGCPADPALGKSVDIDFSSGSSSEFTESGAPTYDSNGAAFTIAKSGDSPFIASKWYIMFGHVDFVVKAAPGTGIVSAAILQSDDLDEIDWEWLGGDNTQAQSNYFGKGQTTTGYNRGAFHAAPSNHDEFHTYSIDWTANEIVWSIDGTTVRAMTQDQAVAGQYPQTPMYVKVGAWAGGDPSNPQGTIEWAGGLTDYSAGPFTMYLKSVHVTDYSTGSEYSYSGTSGTWQSIVSTGGKINSQGDGTPVSSSTPSVTSQVTTGSAPLAFGNSDGDSTTTTRTGWPWSGTATTTAVTVTPTPSSSSLLPSQSGSASASSIEASGSSRSNTSPIATTSRRTSSEVVTAPTTSISAPGTSQASGTSQSSNPSNGFHSSSTTAVTKASGNRSSAATTTSAQSSSSTNQTGSMTLPTSTRSASISSPLPTQTGMPPAPNNAFQHFAFDSWMILSVAIFWFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YS91</accession>
    <name>A0A0D1YS91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_02388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238317.1">
        <property type="nucleotide sequence ID" value="XM_016376747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YS91"/>
    <dbReference type="STRING" id="91928.A0A0D1YS91"/>
    <dbReference type="GeneID" id="27329471"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02388"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="54"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="223"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="77791" checksum="57B8BCE69D6B99EF" modified="2015-04-29" version="1">MDSIARNQLTAADIRRLEDGPQNPLTDKPWPSNHQEILNTRRRLPVYGKYEEILGVYHQSQVMILSSDTGSGKSTQVPQLLVYDEWASGLQVACTQPRRLAARELADRVADEMGVIYGEEVGSHVRFEPKTGKKTRLVYMTEGILLRKAIGTDKNLKDFACVIIDEAHERTANTDLLLALLKGIVARRQDFRVIIMSATIDADEFKRYFNDCPLLHVPGRSYDVEQHYLELGNEQPDCIVSCARSAAQIHHEDGPGDILIFMPGEDEIAGVCEILRLNTTNLTVFPLHSSLPQAMQKQALEECQTRKCIVATNIAETSLTIDGIVYVIDSGLSRQEVYNPRLQMHMLQVRTISQASARQRAGRAGRTQKGVCFRVYTQAAFDNFIPSTRPGILCQQLESTILTLAAAGHSKVMDFDWISPPHPESVSRAAYNLHKWEFLSVDGALTPSGIHAAKCPLDPMWYRALVVATAHGCTMDILDLASISSVQGSIFTRPKKFQQVADIRKNKWAHPSSDHLALLNAFHAFENAWEERNNPGVDLDKWCFDNFLNRRVLEEVAQIRKDLIGFLRLVKMKPTRASITNSVSIRKTLAIAFCTHLAILFKNDEYRTVPGNSPGLLEPTSGLNGRGSQWIVFSTYRLSGVKPYFQPATAIDPEWLVEQHIFKTEDLPKKGDGTFRQQWAKESLDKAGARAQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUI8</accession>
    <name>A0A0D1YUI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239137.1">
        <property type="nucleotide sequence ID" value="XM_016377567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUI8"/>
    <dbReference type="STRING" id="91928.A0A0D1YUI8"/>
    <dbReference type="GeneID" id="27330293"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03210"/>
    <dbReference type="HOGENOM" id="CLU_2687854_0_0_1"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="74" mass="8351" checksum="BBA0B4058652D1A4" modified="2015-04-29" version="1">MALGRFPALHKIFLREVQDGFQSGAFTSQDLVRAYVKRIEEVNNEVHAVIRIDPDAIETAKALDEERKTKGPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVU2</accession>
    <name>A0A0D1YVU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_03691</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239612.1">
        <property type="nucleotide sequence ID" value="XM_016378042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVU2"/>
    <dbReference type="STRING" id="91928.A0A0D1YVU2"/>
    <dbReference type="GeneID" id="27330774"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03691"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="47"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="541"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW19396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="571" mass="63955" checksum="5D73E5A173B7FDBD" modified="2015-04-29" version="1">MAPQTAFMTVHFDQYNPNSEKGTDTRASLASLDYSPLRRVTWRSFLMGVLVSMGGLIFGYDTGQISGFLEMPDFLDRFGQRKPDGTPHFSNVRSGLIVGLLSIGTLIGALVAAPIADRMGRRLSISAWCLIVAVGFVIQIAANTSWVQVMVGRLVAGFGVGALSLLVPMYQAETSPPWIRGALVCTYQLFITLGIFLAACFNYGTYTHQRSNSGSWRIVIGLGWLWTIILGVGILFFPETPRYDYRRGQRERAKETLMKVYGAPAHHYSVHVQMEEIDNKLRAEVQTKGNPVSEFIGMWRAPRMRYRLLLGMALQMFQQLTGANYFFYYGTTIFQSVQISSFVTQMILNGINWGVTFIGLYLVEHYGRRKSLIAGSMWMFVCFMIFASVGHFSLDLDDPARTPSAGVALIVFACLFILGFATTWGPMVWTIQAEIYPSKYRAKAMSLATASNWIWNFLIAFFTPFITAAIDFRYGYVFAACNVVAGILVYFFVIEGQGRTLEEIDTMYLEHVSPRKSAKWVPPPAAEMARIQREAGTAEIPKPERGVYSGETERNDLSGENNKTAHQEEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXW3</accession>
    <name>A0A0D1YXW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00691</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240332.1">
        <property type="nucleotide sequence ID" value="XM_016375056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXW3"/>
    <dbReference type="STRING" id="91928.A0A0D1YXW3"/>
    <dbReference type="GeneID" id="27327774"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00691"/>
    <dbReference type="HOGENOM" id="CLU_024080_1_0_1"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="563" mass="62010" checksum="1879DCC353916F48" modified="2015-04-29" version="1">MGRRKIEIRAIKDDRNRSVTFLKRKGGLFKKAYELSVLCSVDVAVIIFGNNKKLYEFSSGDINETLRRYQYYGQPHEHKGPIDFKNKGGDDDDDEDEEEEQPGHVREDSHPPQHAMPQHMQHPNSFTHIQQPMNSVSPPMPSGMFQPRHGTPQPPHMISRPSSQNMIRRTSSNLVPMQHPHPTPPPPQNGFAYVPNPPIYNPNAPPNMQPHPSPQPQYQYPQQQQQQQQQQQQQAQPTPPPQSHQQMQQAHQQYLQEQRRQSQTPQPSLQPPPQPQPRTSPQPETQNLRPPEQGTPPQPKHLSSKSRSIFTPIDEGGSVLAQHFFGAPDPKPVKKEVEARDAKMLPRSITAPAVGKDPAQPPRSQTAVPEFAPPKRSDTSGSKSGARPKLNLQIPSEAEDNDSPSGSTGQSTDPSGNTARGSDHIVLPPPSPSASAVMSAGASGPPNPFARPHPPPTSNQNREAYNDNRNNIETPISALPSRYMNNDLLPSPSNFFSDWFDGGRNGGLNSAVLPSPLAFPTPSDGRGLGFGGRDTANEASGNGEKRKGSVDMADKEDVKKIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYP5</accession>
    <name>A0A0D1YYP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240627.1">
        <property type="nucleotide sequence ID" value="XM_016375351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYP5"/>
    <dbReference type="GeneID" id="27328069"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00986"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF58">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="508" mass="56213" checksum="ADA20E7585A24B8E" modified="2015-04-29" version="1">MASASAKDGVKVFGESPASSPPYINGADESIEQTPDGTDHEPDVDVLQNRFQDESVRAKAELHLRRKIDLRLCTIAGILCSLNLLDSGIISSASVTSMLSDLDLVGDRYSVSIFIFTVASICFQLPSTILLRLVGPRIFFATITCAFGIITMCTAAITTWRQMIALRVLLGISMSGVFPGLTYLISTYYTRREQQLRFAILQSGEITILATGSIVNYGLNHLDHRHGLRGWQYMYLVQGAVTVFLGIVTYFWMVEFPDQCENSFRFLSDDEKILALSRINEDRRDGGKPEPLNVSAILVNFLDVKLYVFCTLFFLLNIVSTALSYFLPIILQSGMGFDTNKAILLSSPPYYYAVIPVLISSYVGDRYRIRAPVIIFNAICLIVGFCMLGFPSQVTVRYIGTFLATGAYISNWAALNAYQANNVVGQWKRATVAAAISACNGLGGIAGSYIVRQPEAPRYLTAIWVSIGSHIAMIAVVMGCTLWFWDANRRARLGDRLIEGVASFRYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZ99</accession>
    <name>A0A0D1YZ99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240827.1">
        <property type="nucleotide sequence ID" value="XM_016375551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZ99"/>
    <dbReference type="GeneID" id="27328269"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01186"/>
    <dbReference type="HOGENOM" id="CLU_1619028_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="164" mass="17552" checksum="77EEC8295572A3E7" modified="2015-04-29" version="1">MPPTHSQKHAVASEKSFYTPGLVAASDGNARPAHVPPQQYDSSPPPTHAQAQAQAQAQALVQPPPYPQNIPPQHQNNHHLQPHDLAAQLPAAHVLAPSSVAFGPHGPGVGPGPGAEARRGDHNPANAMEPMASLWWHARTTHAVHARRHRWPILPPTNAAHQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZBR5</accession>
    <name>A0A0D1ZBR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230653.1">
        <property type="nucleotide sequence ID" value="XM_016385709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZBR5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZBR5"/>
    <dbReference type="GeneID" id="27338484"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11401"/>
    <dbReference type="HOGENOM" id="CLU_010714_4_1_1"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007354241" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="21"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="604"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW10437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="643" mass="71206" checksum="DE94951565BAA10F" modified="2015-04-29" version="1">MNFLLAAAILCCVSIDNVAAFYLPGVAPSSYSEGDRVPLTVNALTPSISRHDEQIHAVVSYDYYHPAFRFCRPENGPQRVRESLGSIIFGDRIQTSPFELNMGQNETCKVICASADFDEKSVGFVRSRINEAYNVNLLVDGLPAAELREDPLTHERFSSPGFPLGKVREDGAVILNNHWDIIVDYHKAGLRGTKYRVVGVLVQPQSYAESKVTGPGKAECAVDSGPLMLQDGAGTKVTYTYSVYWRPSDTAWATRWDKYLHIIDPKIHWFSLINSTIFVIFLVGMVSSILVRALRKDIARYNRLDNINLDDLSGTSAVGDDIQEDSGWKLVHGDVFRSPRYILALSVLLGNGAQLFVMTGVTVAFAMLGFLSPSNRGWLTSIGLLLYTMFGCIGGYVSARVYKSFGGEKWKLNIAATPIFVPGIVFGTFFLLNLFVWAKGSSGAVPFTTMLAIIAIWFVISVPLSVAGSWYGFKQSAIEAPTRINQIPRQIPPVTRSLRPLPSLLLTGILPFCAIFVELYFIMTSLWTSKIYYMFGFLFICYALMVLTSACTTILLVYFLLCAEDYRWQWRAFLGAGMTGGYVFVNALGFWVTRVSFGGFTGAVLYVGYSALISFLVAVLSGTIGFFASYAFVYRIYSSIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZCB9</accession>
    <name>A0A0D1ZCB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11641</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230893.1">
        <property type="nucleotide sequence ID" value="XM_016385949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZCB9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZCB9"/>
    <dbReference type="GeneID" id="27338724"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11641"/>
    <dbReference type="HOGENOM" id="CLU_047725_0_1_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW10677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36541" checksum="11CA857D1F2DFC1F" modified="2015-04-29" version="1">MATTTVTETVERHFIPIKVDELPPVQTFTVDSDPEDVIKALKISGGCKVKGAVSKEILAQIEKDLRPHIEADVVWEGDFFPIQTRRVEGMIGKSPICAEHVINHPLYQAVCKEFLTKKNWYWSGDKKIFATSDPQLNNSICFSIGPGAWNQPLHRDSWCHQTNETEVAVYPDNYDREVGIGWFVAGKPATKENGATRFIPGSHLWSKDRPPQEELAVHAELEPGDAFMMLSSCYHGGSANKTKDQERLLFSCFMTKGFLRQEENQYLAIPRDVVLKMPVHIQQLMGYKLSQPFCGWVESDDPRVVLDPSLKDDPSGHYDEDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHK4</accession>
    <name>A0A0D1ZHK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232613.1">
        <property type="nucleotide sequence ID" value="XM_016383990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHK4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZHK4"/>
    <dbReference type="GeneID" id="27336757"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09674"/>
    <dbReference type="HOGENOM" id="CLU_078561_0_0_1"/>
    <dbReference type="OrthoDB" id="3689214at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252806" description="Mid2 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="32717" checksum="6DD6946A1DAA25EF" modified="2015-04-29" version="1">MLTMVSQALLYSFLLIKASVFAQEVVPWSIPDGAKPNFTEVYNDGNSITWSWQALNHSMSDLWLTSYDPTLSYAVRIASNINITEPGTLPWTITVNQTLIDIDDRFVLRFTLTGTDIYPLSPSQFPSPAFIVLKRGETLASTSVGATATVLGVESITIEIPTATAASTNITSVGAASSVPSGLLDGNSSSVSPSSSSGSGLGTGAKVGIGVGVAALVVVILGLCFVVLRLYRRLKATSNRHSQGIIPDHPEKDNMTSASSTPAVREISGLHEALGDRRHPTELGSKQESRIAELGSKHESRIVFEMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIU3</accession>
    <name>A0A0D1ZIU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_07969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232998.1">
        <property type="nucleotide sequence ID" value="XM_016382295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIU3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZIU3"/>
    <dbReference type="GeneID" id="27335052"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07969"/>
    <dbReference type="HOGENOM" id="CLU_010089_0_1_1"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF10">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="435" mass="48561" checksum="51B967E4D9A2C73E" modified="2015-04-29" version="1">MPARPLDVLGDYGLSARTGFLPEEAPLTRLPDDYYEPWEDLIQNLAQLVSSYKIRSRIDQLPLLKTSRLKTEEEWRRAYVIMGCCVQAYIWVGETPSDRLPPQITIPLLDAASYLGLAPMNTYATIVLWNYGLLPGESDPTNPSNLRSTNTLTGTRTEEWFYLISVTLEARGGPIITELLECMSSVRQGDDAAVVASLERTACHIVAVGALLNRMYEHCEAQPFYYDVRPLLSGTKGHASLGLPKGVFYDEGDGKGSWRQYAGGSNAQSSLIQFLDVALSVKHHATGQDGTLRRPSPSNRGFIEEMRQYMPGRHRDFLCHMEKQAHIREYAMSTEVSDPRVRAAYIEAVAALTQFRNIHLRIVARYIISPSRQPVPENSKLKVGWNLAKTAPNHNVGEEDVAKLQGTGGTKLMAFLKQTRDETSMAAKFPEIASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZK88</accession>
    <name>A0A0D1ZK88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233463.1">
        <property type="nucleotide sequence ID" value="XM_016382760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZK88"/>
    <dbReference type="STRING" id="91928.A0A0D1ZK88"/>
    <dbReference type="GeneID" id="27335517"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08434"/>
    <dbReference type="HOGENOM" id="CLU_037139_1_0_1"/>
    <dbReference type="OrthoDB" id="5373426at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45164" checksum="C023FB75EEEF7F52" modified="2015-04-29" version="1">MEYRRRLIRMQFKRAVAYTLLAAGLVWFMSVEVLHSGFSSSTYLGDSACNNREHHGETTPSVLTGPPHGNTSSPLAPSSAIDTFAGYKYRNHTACQISSLDLHLPSSAVCRNRTALLQAFSGGGRIGLDRPYFPLGCDIRWFTTEEACQILSRFEKVIVIGDSMMRHVVGAMNVLLRRDLGYGAVTNWNFNEEELRDCFCNHQMDVKSCSVQGIFSTSSVLEHDPSSLACPPNQPVDLVIEMMLKYPLDPEELARFRDLLSPRKPHKPYAFVFGHGLWNDLDLKASMHWLDGILEETIKQSPYYTRYASGSGPPFWPRLFVTPNAAGPQKPDQWLVSQGNKALMVFEESVHVEAGKRGVETLGTWNMSIQATKYDGVHLDLKGNLIKAMGVLNWLSMLDIDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZLI8</accession>
    <name>A0A0D1ZLI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233913.1">
        <property type="nucleotide sequence ID" value="XM_016383210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZLI8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZLI8"/>
    <dbReference type="GeneID" id="27335971"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08888"/>
    <dbReference type="HOGENOM" id="CLU_016972_0_0_1"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237795" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="30"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="374" mass="40626" checksum="F2F0A97906732EC9" modified="2015-04-29" version="1">MISHMSTAGVFALVFCDISQAIDLVVPTYSMVRNYTGPSIYQNFDFFSDHDPSNSFATYVDLTDANSSGLAGYQSSKDEPGPVYLGVDHQTITPNGRPSVRLEGQDTFNHSLIVADIHHMPWGCGTWPAFWLLGQGTDWPKAGEIDIIEGINNQSVSIMALHTKKGVFVGNLTSAYAGNTQMAGTFTNLDCNLDSGGTTGCAAKASWKNYGAEYNAQGGGVVVTEITSDAISIWSFPRDRIPQDVLSGRPNPHPLYNGSQWGPPEAKFVPAFNSSFDDHFFNLKPIFNTAFCGPWIDGLWNASECASLAPTCSEYVSNNPAAFSDAYWAIGGIQVYEPIMNTTSGPQAFNSSTSQPNSTYDRKCRGHSEDFKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZNG0</accession>
    <name>A0A0D1ZNG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234593.1">
        <property type="nucleotide sequence ID" value="XM_016381491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZNG0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZNG0"/>
    <dbReference type="GeneID" id="27334242"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07159"/>
    <dbReference type="HOGENOM" id="CLU_113770_3_1_1"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000011">
        <property type="entry name" value="Transcription factor Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12041" checksum="C84A7999A418441C" modified="2015-04-29" version="1">MAASEFPCSLVIDVPFPDHRLASTAMRSLKVDQEPSSSVQRSYSLVDSKGNPPSENENESGTILRTEYNATTNRMLRVAVNGFMESLGVVLQVMEELDDVDVSGMRSSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZNS4</accession>
    <name>A0A0D1ZNS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_07241</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234673.1">
        <property type="nucleotide sequence ID" value="XM_016381571.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1ZNS4"/>
    <dbReference type="GeneID" id="27334324"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07241"/>
    <dbReference type="HOGENOM" id="CLU_006595_0_0_1"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="198"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="570"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="715"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="946"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1082"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1321"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="726"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="803"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1328"/>
            <end position="1339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW14457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1360" mass="153721" checksum="9640EBA2159B8D20" modified="2015-04-29" version="1">MNTSNQGSGFDDHVWSQLQNMSHQSSQRGRGARSNWGGRGQGRHHRGASHSSHMNQSAFMSNQASSQLPPTTDDFPPLGSGSSSAASLRSDLPFSAPQPPQLHPQPFDSARHGTPREYQDRARGDFRGRGGRFGPHAPMPPMAPATMTQHHGHGRPYPRQTNLYHPHSDLFYGTAEQQRNMRHILMKQSDYLRVVARDAQEQHRLTPEEARLKENFRRDLELVARETLGAKYPELDADQIKLKCYGSLANGFALANCDMDLLLFLPSRQDNRKSMTSPQPDAEADAYEDSEDEERLFNVEVRRVLEKAFLDKAYGARLLTNTRVPILRICERPPPELLHNLREHRAAWEKSSFQSAPELNLTEINQVGKASQDQVLQEEDSEKNSKEAGAPDSVKTNEMQDSIPTEVDVLGEAIGGLTVEDESSQKPAKRTNPKLEFVGDCGIQCDVNFTNFVAEHNSRLLWTYAKLDPRVGEVGTFVKIWAKARDINTPYRGTLSSYGYILMVLHYLMNIASPPVLPNLQYLAKTEDSWYPDRKITLFEGFDVRFLRKPEEIQHLQETNSKPNKESTPQLLRGFFRYYATREGFFWTRDVISIRQPGGIVPKAQKGWTEAKWVEGRNTNVRLRYLLAIEDPFEIEHNVARTVGHHGLVSIRDEFRRAWNLLERVGFGEQIPVEAFLEPVTDRVDTLRKDQDFHRQKQLRQMKQDLEDKEKVLLEEKGRDDVASHTDGTLGTSIPGTTQSTPSEGQRRSSNTKLTSTLSYQAQLKRRQPWRRRMPTADSDSESDIDDSSSEHKEKSAISPGDQSEKESSQKSEDKKMPLKRLVHASIGDILLANGRDAWGNLVPWDIDTQDGRWLHWRDNKIKNGTYRGFSNPTMQELDEQCPFDPQRPSPYSVKPYDNHIEKFLSQDQRPPWPAITPADFPTTNDPRTPPSDLDVSYSIRRKGREYDPSVQTIPTPKDDHSVGGSIPWDRTTRGGRWLCTRDKRILDGTWRGPHRNNWYSCLDASFPYNPSMTWKELEERNHLLRSYCASQLWPSSTPARLALKAAAEEVNVAYSAPRKESLRMIPAQVLLNHHNRQIRGPASLDSALSPSEIPSKNWHVKPGSSHSAPQAKDAASTGAISCSQYDDTRASPKIPYNDNESPDQDALRARRLAYFAKQFATPEIDVDLEAKDRSHHDAREQTFAEVQLESMAPAASGQGSTYPHLGTSLVLAVNGHESANRERSEFEDAVGARHSCKNGNLKDNHKCSELRVPSTLLPNMDRNERQRDEDPDIIPIPRKLGFQFDPRQLQDLAVIAKGGNGCARQGEEFNIEDEYEWGGGGMMGRRTSTALPYLSSGTPYEPGKGDEEGLLNELPGEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZUC0</accession>
    <name>A0A0D1ZUC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236598.1">
        <property type="nucleotide sequence ID" value="XM_016380771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZUC0"/>
    <dbReference type="GeneID" id="27333516"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06433"/>
    <dbReference type="HOGENOM" id="CLU_1102683_0_0_1"/>
    <dbReference type="OrthoDB" id="4121240at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="299" mass="31204" checksum="B69B2B58E0229BB0" modified="2015-04-29" version="1">MAPSPRNRFNMNNHQSDEIISHGVGSSSSSSSPNGANTISHNQSNGSSSSLSTGAIVGIVIGGVAGILLAVAAFVVIRSRRRSRTGGAYRPANARGGFFNTRREAPIGEKPEDIKPEGEGEHAADEGLLRHADTPAIVAWDADEEDDLQNARGTRDGVAHAHPHARARTGIQRPASVASFSSLSTAAAGFAPPPPRYEEAMSSGPGARASTSTRRNSDGGLAPLMLGRADEDDDDDDDEIGGGGRRSTSRGRSLGTNTDDLGAGGSARPRSVNGDRRRSVSRFREEGMVDLNLSSNLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZVW7</accession>
    <name>A0A0D1ZVW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">18S rRNA biogenesis protein RCL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237063.1">
        <property type="nucleotide sequence ID" value="XM_016378386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZVW7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZVW7"/>
    <dbReference type="GeneID" id="27331120"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04037"/>
    <dbReference type="HOGENOM" id="CLU_027882_1_0_1"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000004">
        <property type="entry name" value="18S rRNA biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="207"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="406" mass="43088" checksum="D6F92AC5262EA334" modified="2015-04-29" version="1">MSTSQPPLRLSSHNSLTSRLVLSTLLGRAIRIDQIRPDSPTNPGLAPHEISFLRLLEAVTNGSHMEISYTGTVLLYRPGLITGSASGSGASSSGVIRHEIAANNTRGLSYFLIPICLLAPFSKTKFNILFTGQGVITSATEKWGDMSVDSVRTAILPIYEKFGIERDIELRILKRSNPGPRGVGGVGEVQLLFGHQVRLPKTLHFMNPGRVKRIRGVAYSTGVSGNNNARMIETARGVLNQFVPDIYIFSDVGSAQLITVQERGSQGTTKRKVGLGFGLSLVAESTTGALYSADAVCPPEGGKPAEDIGRMAAFELLESIEKGGCVSGEAVETVVTLMAMGSEDVGRVCLGRDVLANERTVQLARDLNAFGAAGWGIKDADGEKAEGLLQVSIVGRGVGNVGRKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A2L2</accession>
    <name>A0A0D2A2L2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_03481</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239403.1">
        <property type="nucleotide sequence ID" value="XM_016377833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A2L2"/>
    <dbReference type="STRING" id="91928.A0A0D2A2L2"/>
    <dbReference type="GeneID" id="27330564"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03481"/>
    <dbReference type="HOGENOM" id="CLU_013299_5_1_1"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="27"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="321"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="471"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW19187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="524" mass="58703" checksum="9EF3E09EAEBC6674" modified="2015-04-29" version="1">MAAPTPDRPKVTGRAFYESIGSPKWIVAPMVDRSEFAWRLLTRSYLDEERSKSLLAYTPMLHARLFQEGPRHRDAYFRPTRDSLVSKVRSSLPPWLDGNPELDRPLFVQFCANKPEELLEAAQYVAPYCDAVDLNLGCPQGIARNGHYGAFLQEDWDTIYSMINKLHNELSVPVTAKMRILETREKTLEYAKMIISAGASILTVHGRRREQKGHNTGLADWSMIRYLRENLPADTVLFANGNILNSGDIDACLAATGADGVMSAEGNLSDPTIFALPPKEHNPREYWYGPNDKGGYRVDAVFRRYMDIIYKYSFDRAPPERPPLYIPGDPKPDSTKEITDPASQNGATNSKKRKRESKPKTDPNLKCMQGHLFHLLRRLVSVHTDIRDALAKSRCGDMDAYEHVLSMVEKAVMEGLDAEAQGTGEESSQQEVASLGENVPPKQKTEAKYKRPWWVCQPHIRPLPEEAVKLGAMQPSKKELAKLAAQESSETKADPLQRVDDGQQQQQPSPTSGDDVPKSALVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3P9</accession>
    <name>A0A0D2A3P9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239708.1">
        <property type="nucleotide sequence ID" value="XM_016374432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3P9"/>
    <dbReference type="STRING" id="91928.A0A0D2A3P9"/>
    <dbReference type="GeneID" id="27327147"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00064"/>
    <dbReference type="HOGENOM" id="CLU_1224795_0_0_1"/>
    <dbReference type="OrthoDB" id="2351920at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="226" mass="24748" checksum="9D6463C774DE578A" modified="2015-04-29" version="1">MTLLDSHQSPVVNGSESATSTKNELALDSDAYPQHSVLPGIDEIELKSTDSSESVGGSYTPHNHEMRASPLSQPSKPTWSDLAAAVNTWKINDDGSRAEGEVEKSRTPYSVLKLLARHGGGVDGQCRPKRGAISQSPRQNLFDREIEAEGQARVEMTEYIDSLVDRAEYEEAYACVWPLEEYRRQGWATEMVKAYPSESEAFIVGVVNEQSSGAQAEEDEAAAGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5P7</accession>
    <name>A0A0D2A5P7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240303.1">
        <property type="nucleotide sequence ID" value="XM_016375027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5P7"/>
    <dbReference type="STRING" id="91928.A0A0D2A5P7"/>
    <dbReference type="GeneID" id="27327745"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00662"/>
    <dbReference type="HOGENOM" id="CLU_053380_4_0_1"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000013">
        <property type="entry name" value="TRAPP complex subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="166" mass="18700" checksum="DA38D0B1E3C1F061" modified="2015-04-29" version="1">MVVYSFYIFDRHAECIYKRTWLPAYMSTTGKTSRPSSQAYVNGGTTPVRGGLSADDDAKLIFGTVFSLRNMVRKLGGDDDSFLSYRTSQYKLHYYETPTNTKFVMLTDTKSGSMRIALQQIYVNCYVEYVVKNPLSPAEHPGGIGVNNELFEASLEQFVDRVLNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A9E5</accession>
    <name>A0A0D2A9E5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241608.1">
        <property type="nucleotide sequence ID" value="XM_016376332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A9E5"/>
    <dbReference type="STRING" id="91928.A0A0D2A9E5"/>
    <dbReference type="GeneID" id="27329055"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01972"/>
    <dbReference type="HOGENOM" id="CLU_051033_0_1_1"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="7">
        <location>
            <begin position="174"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="275" mass="29542" checksum="30C2495DA8FD0228" modified="2015-04-29" version="1">MDYGYNNQYSTSYGANGGADGGGFVAGEPQSSPAAGRGGYGKDTVRPMTIKQILDSQQPHPDADFRADGEPFGLVTFVGQIQGISTQPTNITYRVDDGTGIIEVKQWIDSDSSKGDKMDGVESDKARLVENGYCRVWGKLKSFNNKRHIGAHVIRPITDFNEINYHLLEATAVHLFFTRGPPQAHQANGQQATNGGGQQFGSAADGALPGVSPLGRKVFQTLKNTAQTNEGLHVQMIASQMGMPVAEVYKGAEELLAIGMIYTTVDDNTWAVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A9P5</accession>
    <name>A0A0D2A9P5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">tRNA wybutosine-synthesizing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PV08_02047</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241683.1">
        <property type="nucleotide sequence ID" value="XM_016376407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A9P5"/>
    <dbReference type="STRING" id="91928.A0A0D2A9P5"/>
    <dbReference type="GeneID" id="27329130"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02047"/>
    <dbReference type="HOGENOM" id="CLU_007952_1_2_1"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="125"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="429"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="303"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="744"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KIW21467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="779" mass="87085" checksum="35EE8086A0879A07" modified="2015-04-29" version="1">MDLGDGGATPVVLADWLDRLLTSWHDYRVAVYSVVALSSLLVWLYRRRAPTSSPDPRKAHWLEDEDKVALPTANGKTSLDNKQQPATGTTRKPRYSAPKVVNGRKPSPRGGKGSHERDGPAHILPLVFYTSLTGTTERLSKSVLAKLQSLPTAQPLVLKPQLHDLSYVDLDDYFISGPKTPGPSSNVRYFYILLLPSYDIDTILNTFLDHLDETHNDFRIDTASLSGLAGYTVFGIGDKNGWPTEEAGFCSQAVEVDRWMSKLTGRKRAYPLGLGDVKSNIDQTLQDWTAGVCDVLQELSTTGGLGEGVPGSGDAVESGDEDDEEDRQQEEVDFPDSGRNKRRKLRSTTDLEDVGGKGAVMAVDFTTYSRSPAAAVAPLKAMVPKESPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDDPQMIFDGAKEGHYKKIKMMRGVPGVRSERFEEAMRIRHCALSLVGEPIFYPRINEFVGLLHSEQISSFLVCNAQHPQQLRDLRRVTQLYVSIDASNKDSLRKIDRPLQRDFWERFQSCLEILREKRFVQRTVFRLTLVKGFNIDDEAEGYADLVEKGLPCFVEIKGVTYCGTSTSSNAGLTMQNVPFYEEVVAFVEALDRALAKRGLDYGIAAEHAHSCCILLASKRFLIDGKWNTIIDYDKFFTLLGEGADFAPEDYCKETPEWALWGNGGFDPRDERVDRKGRPKEKKADKEVLRTVLVEEKKSLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AST4</accession>
    <name>A0A0D2AST4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230004.1">
        <property type="nucleotide sequence ID" value="XM_016386196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AST4"/>
    <dbReference type="GeneID" id="27338971"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11888"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF36">
        <property type="entry name" value="CHAIN OXIDOREDUCTASE (CSGA), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="272" mass="29409" checksum="E864431EC78ED420" modified="2015-04-29" version="1">MSSYLVTGAGRGIGLELVRQLAKQPPGDVSTVFAATRGKASDTLKRIIDSSCGRVVHVSMVITDRSSLDRAASEVEDKLGGRGLDVLINNAGVMPSDVRGVVEMSTLRYALEVNLEGTQETTAAFMPLLKKGKGKKVVNMEVYPRSLGPLHPPLIGFSDTSFGSIAQAPKYNWIPTPSYKISKAALNMLTVQYAQEYAKEGFTIFALSPGWLKSDMGSERADLDVEVGTEATLDVIFKSTSENTNGTFQNILVPGWENAEGPNQYDGKMIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATG4</accession>
    <name>A0A0D2ATG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230209.1">
        <property type="nucleotide sequence ID" value="XM_016386077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATG4"/>
    <dbReference type="STRING" id="91928.A0A0D2ATG4"/>
    <dbReference type="GeneID" id="27338852"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11769"/>
    <dbReference type="HOGENOM" id="CLU_190851_0_0_1"/>
    <dbReference type="OrthoDB" id="2555959at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW09993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="64" mass="7091" checksum="13CF0A77F234AB2F" modified="2015-04-29" version="1">MSLWSSYKGLPPKTRGLIGIALMVNASAMLMFSDQIEGMLGIAPNTQEGQKLLKVYPVEREKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATQ6</accession>
    <name>A0A0D2ATQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230324.1">
        <property type="nucleotide sequence ID" value="XM_016385380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATQ6"/>
    <dbReference type="STRING" id="91928.A0A0D2ATQ6"/>
    <dbReference type="GeneID" id="27338151"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11068"/>
    <dbReference type="HOGENOM" id="CLU_398498_0_0_1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="273"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="691" mass="76764" checksum="88D32F052961F644" modified="2015-04-29" version="1">MRRAHCVYSDLPANRVAHPPAGPTGLSSDVDASARSSTVANHNQRVTDRVFDGETARRAVVDPPRELPRFDPTVNNAVTENATPVSSDPSISQWPIGSCKESSTSFLQDHLASFWADRASIGRDPIVSGNDLTEDDVTTPLPFIPGSGRQSFVSLEEQLPDKASASVWLNTFLKGPNMLFRICDEADSWRLLDTVYGKDHVDETQKCSIWLQLATGCRFTTGTAEETYTKLYDSGCQYLEWCIEQADEVAPLWVLPSMLLECLYFLDSKPKTCWLTLSSAIRLAQVHNLDQEKGSLPGLSGEEYERWRQVWRAIIFFDAWLSMTLGKTPQINQKTTQDPFVNMTLEEFAAPNPDIEVNVAKLSVLISRFLSGLSQGSMYPSIQEAFFHALEVWASNLPQNLRHFPDITAPQSSQADEAGSLYLEAFYFSSVTVLTKPEFFLSLFAAKPQSSRIGIFAQTCVDSSAQIGHLSSRILERGLLCKRSWLVATLAYHAGLVLCLSLSVQVTSLRYNLKPPGSHRVESDGLTAVMNVLSTCTSHSTLANHHHEVLRYFWKLIKNYEEAAYPTPPSWPDSTVTPRGSMSFGMWQTSPDPLPSTSSALSSSSYDFTAGSDYSFPTASEISQSAAARYHSQGMPDPSLLPWAGSMPHYDSSQSSNMNLESRQTSVNYGSGHYKPYMENFWSTETIEFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AU00</accession>
    <name>A0A0D2AU00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230166.1">
        <property type="nucleotide sequence ID" value="XM_016386034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AU00"/>
    <dbReference type="GeneID" id="27338809"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11726"/>
    <dbReference type="HOGENOM" id="CLU_398497_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="691" mass="77881" checksum="4C344984F3BE3F42" modified="2015-04-29" version="1">MNSHYCSDCRIQLQAGVLVCWNCHKSTTLPHSPETARQSAQQFQHGRGLPTRDARDLGRPQLTRTSTPLSTYRRYGEDNTSTVSIQRSGSESRLPLSVGGRSNTDSQHSSTLHTTRRPGYTKTPPRRLNRKRKRNDRDNESESTDLYGASGDENSHTSREMPPPRRADTVASGSHAAVTPQAARPLVVSENVVPPYKEGDPFDRITMKYGFVGTIREKVFVGTSCQHCNGPHPTYYHNKGYWEVLKRSGTGSPNVTCGRCCQLGHEADECGKGDWRDLPDNPPLLPEHSAHARPWPRSDGCVPFPRHYYRPDLYPKPDPTYPNLPADIAKIGFRKGFARKEWGLQHSIDVLDAKRRNVREPKINRKDFRPWSPPQTPFSDLVQDVKLEENVSATVLANPDDQEAPRRDNGSQLPSRRELNLPYNRKRGQLCSPGFNGLVLPSDLDALESHRHNAVSGGGPITATRNGRHPQLEPQSDEDANHHIKELADYVFGEQVLDSDMVETYTTFIKQLMADVNDKALEFSNIIRAKQSDLVDKSEFTSSEQSLKQFLLALKRLPHWWTYEVTRLANTIETACAVYSLESSGLNDFYELQQMLKQAFDTFESEMARHLSCCFKIEGITFIPWLEANDGKTLTDGIQGALLPGESSPRAQLPRFAWPQLFIDPLRKDRSPKNRDIDMTVETGQDKSACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUQ6</accession>
    <name>A0A0D2AUQ6_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230674.1">
        <property type="nucleotide sequence ID" value="XM_016385730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUQ6"/>
    <dbReference type="STRING" id="91928.A0A0D2AUQ6"/>
    <dbReference type="GeneID" id="27338505"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11422"/>
    <dbReference type="HOGENOM" id="CLU_065858_0_0_1"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="386" mass="42594" checksum="F0F313709073BC46" modified="2015-04-29" version="1">MAADDSATGLLTALTSALQLATSTFPDDEAQFLPPSEGISLLDIKNDLLLSYLQNLTFLILLRLRQGDGSHGHQDVGAEVVNTLVELRVYLERGVRPLENKLKYQIDKVIRAAEESDRREANKGSTALQKKKDRSIPTTKSLNPGSDVSASESEDVESDEEADGDTDGDMAAAPRPAALQRKIDPSQTRAQSATSRAAGTGAYKPPRITPTAMPEASSTRDRSDPARKRRSQLLDEYIDEELSSAPRAQPSIGSNSTIVQHGRGAMSSRERERQKERTEYEERNFVRLPALSKAEKRKARSQGERNQRDLFGGEDWTGLGGLGDRINRTVAGRSRGESGGVLQRREKRRRDTQDGPRGDGVGIGETFEKKRKIMQQRADRKTKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AV28</accession>
    <name>A0A0D2AV28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_11307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230561.1">
        <property type="nucleotide sequence ID" value="XM_016385617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AV28"/>
    <dbReference type="STRING" id="91928.A0A0D2AV28"/>
    <dbReference type="GeneID" id="27338390"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11307"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW10345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="64076" checksum="B20B9B4D8F348675" modified="2015-04-29" version="1">MAASISPSVIMTQIHNYLNANETSDALFKSQNAFDTIGTYKWFIGTGIFVLVTAIQVIKYMLRDRPPPGLKLIPGPTSTIPYIGRVHDVDPNKPWFAMKKFCDEYGGIFRSTICGEMHIWVGDAQIAYDLLCKKARIYSSRPMVPAVPGSDSQGQYLPLLAHDDHWRNQRKFAHTVLTAGFNSKYYGYVSHEAKRFLYKLLIDPTDHYALTDRFCGRISARLGYGSPASAAAHCKNAGEFIPQISPSGPITNLMPFLGGLPEWINPSIRKVRERREKEEKLWKGLMKQVRQEMDQGTAPISYARTYFERKEAEAGSRSFGFDDHEAAYAVGMLVTVAIFTIGGPLYCFFLAMVLHPEWQQKIRDEYDEVIGDRVVEVSDAPNLPILRACIKECIRWRPPVPLGVPRLLEEDDEWNGYYLPKGAVIHAVDLALARNPELYPDPETFRPERWLQKEFPTYKEPLTEHPRLMGHHGFGMGRRMCPGIEVTEAELLVACGSIVGCFELLPPKDANGQPQWPDSYKFTPNLIGGPLPFEMEVKVRSPEKAERIKVWYEESVADEAAGKIAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AW12</accession>
    <name>A0A0D2AW12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC multidrug transporter atrF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_11614</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>voriconazole(in) + ATP + H2O = voriconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61912"/>
            <dbReference type="ChEBI" id="CHEBI:10023"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:61913"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230866.1">
        <property type="nucleotide sequence ID" value="XM_016385922.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2AW12"/>
    <dbReference type="GeneID" id="27338697"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11614"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001650">
        <property type="entry name" value="ABC drug exporter AtrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1230"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1261"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1300"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1340"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1371"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1402"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1495"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1521"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="199"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="890"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="71"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="850"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW10650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1546" mass="171914" checksum="A11799C4DDE0EBB1" modified="2015-04-29" version="1">MLTAAATVNDLHNVAGTGPLSEDSTAVQSPRDSGESRAQPRDGTWGERDVGGPVSREDAMADYEQMRRELTRLSLQRTRTRDSAATKPKSRLGRTRTVPSVGRTVTRSSRAGSFASTSSADDTASLSGGDDDLDLGAFLKDGHFEKRTETGESAKKVGVVYEHLTVKGVGAQATFTKTLPEAILGTFGPDLYRLVTKFVPALRVGKHPPTRDLIHDFTGVVRDGEMMLVLGRPGSGCTTFLKAIANQRDSFAGVEGKVSYGGISAEDQRKHYRGEVNYNPEDDLHMPTLTVGQTLRFALMNKTKMHEAGTIPVIIDALLRMFGISHTYGTLVGDGYIRGVSGGERKRVGIAETLATKSSVVCWDNSTRGLDASTALDYAKSLRVMTDISNRTTFVTLYQAGEGIYELMDKVLVIEEGRTIYQGPARLARQYFIDLGFQAPDRQTTADFLTSVGDPNERQFQPGKEASTPRTAEELEAAFRKSAIHQQTIADVEEYEAQLHQTDCANTKRFQQAVEQSKSNSKLVSSDSSYTVSFWRQVLACTLREFWLFWGDKTSLYTKAFIIIANALIIGSLFYGESLDTSGAFPRGGALFFSVLFLGWLQLTELMRAVSGRVVVARHRDYAFYRPSAVVIARVLLDLPVIAVQAVVFTIILYFMANLDVEAGKFFINLLFVYVSTICITALYRMFASLSPTIDDAVRFSGTALNLLLIFVGYTIPMRTLTSDVIWFGWLYYVNPVAYAYEAVLTNEFSDRTMQCSPSNLVPQGPNVDPAYQGCSLTGATVGSNTVNGAAYAKESFGYSRSHLWRNLGVLIAFTVLYILVTAWASETFSFAEGGGGALIFKKTRKAKKMVTQDTKPTDEEKGAVPHDPSSSGSSETIQDDKEPGVNNIAQSKSVFTWENVECEVPYQGGKKKLLNKVNGYVKPGLMIALMGASGAGKTTLLNTLSQRQRTGTVSGDMLVDGRPLGIEFQRATGFCEQMDLHDETATIREALEFSAILRQDRNIPKQEKIDYVDKIIDLLELNDIQDAIIASLGVEQRKRLTIGVELAAKPELLLFLDEPTSGLDSQSAYSIVRFLKKLSRAGQAIICTIHQPSSMLIQQFDMVLALNPGGNPFYFGPIGENGSAVVEYFAKRGTQCPPNKNVAEFILETAAKGGQRRADGKRVDWNKEWLESEENAQMLKEIQRIKEERLREPVKETHTQRAFAAPVTVQTLELTKRTFRNYWRDPSYLYAKLFVSVIIGIFNGFTFWKLENSVASLQSRLFSPFLVLLIPPTIVNGVVPKFYQSRSLWEAREYPSRIYGWVAFCTAQVVAEIPMAIVSSVVYWLLWYYPTNLPRDSSAAGYVFLMTMLFYLFMSSWGQWICAFAPSFTVISNVLPFFFVVVGIFNGVVRPYAQLPVFWKYWTYYLVPSTYWIGGVLSATMRNLPIRCREGESTLFNAPPGETCQSYAGAFVRSVGRGYVEATANGTCAYCPYASGEEYLSTINVRLDQKWRDFGIFLVFVFTNWMLVYFFIYTIRVRKWSFGMGYLFGGLEKVGGLIITRRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AW73</accession>
    <name>A0A0D2AW73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_10044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230961.1">
        <property type="nucleotide sequence ID" value="XM_016384359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AW73"/>
    <dbReference type="STRING" id="91928.A0A0D2AW73"/>
    <dbReference type="GeneID" id="27337127"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10044"/>
    <dbReference type="HOGENOM" id="CLU_025273_0_0_1"/>
    <dbReference type="OrthoDB" id="2142598at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBZ3-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="8">
        <location>
            <begin position="477"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW10745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="81521" checksum="060F493D28138003" modified="2015-04-29" version="1">MASQYVCGQCNETIESDRRDEHEDWHFAKKLEAEEQVEHPRLSQSQNDSNTRKSDHKQRVAGTRDQPPSYAPPSYSPPHSTARATASIRQHTNQVIEAAQIRARDEQQMQNALQSLQFQYQIYNSEIEPEHEADYYCNCPIHNYQQMKFRRYGVQDMWSKAVMYPGEKAYNDNKLGMGLALLSRNPYRFRVVSPYGYYQSSWGVQRPAPGYHAQFIHQTIALNNSLNNDAQGNVDAQEPPINIWNDETPNTAMSQTTSSEDRKPEKPSKVSRLSSFKQTIGIKSSEEKMASRTQKLMAKGRELRDSIIAEENGRWPDEQWRHIVATYQEKVGMIRKIADLRSRQPIQYLHLLRSGYFEPIPVAWANQASNPLKFTIDAAAGWRGVTPAWRGYEDTAEERLYWVLNHREGSTGVRMKPDFISAMDMARARMATAVEPPPEYYSSTDTCHIQHTSAGYSKQVMPTPFVAYDRPEVPTDDTMILLDVSGSMDFDPVRPNYNQYLITGYSKSTQPKNKDVAKAIIRRFSDAMANHDHDFRGYDLTTFANSANYIGTINNQNFDKMWRRVRIGGGTRVMTGWQKVKELHFQKHSESATYHPVYGWQAGPDTPMLRLLLLLDGEATDMDEFELDLLGLSWAHVTIFLIGVDGCPHHHRHANELQRISDVNHHVSFVDAQGNTPERFVTHELLKRHLGYELSMAEFEQLEELPGYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXB8</accession>
    <name>A0A0D2AXB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231261.1">
        <property type="nucleotide sequence ID" value="XM_016384659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXB8"/>
    <dbReference type="STRING" id="91928.A0A0D2AXB8"/>
    <dbReference type="GeneID" id="27337427"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10344"/>
    <dbReference type="HOGENOM" id="CLU_006237_0_0_1"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="593"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW11045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="907" mass="102266" checksum="68754DF5EC270B2A" modified="2015-04-29" version="1">MEQRSVVIRRVRRKQHSSCDQCRKAKRACDASQTVGTVPVDGRKQQSPYAKSATSEERLQVPTAKCSNCRKSGRDCTFSWLQDILPPKATDGGKKKHQHRPTAHVPREQVMFQTNTPHLANTSDTRRSPARSKLDQHIQAWDFSPIANEAVDHCWLEALGDAPQERVCIGQEESSTGFQELGSCKPAPEWRIDDISIEHASGGPSPDDGLEFSTLGWTQDTSSFGDTSFAIPQSDGPLFPLTEPCAAPASSAFGTHVSPSILSEDTLISGTNRWLLAQNWLHVYHDSFENALSCWLTERNCPYTLSQKPDSQLHPGNNYFSIWGPQWSNRIYARVCSLDRFLNNMPRKGLNKTDNSLAGKALHAAVMAFGVQWAQAGPRGDMRTYSSSAGSTSNVHEDMNLPAADEFGRSVQETLWYQARQALQNAAGIESYRVAFANIIFSLTQKPLKLEDWVQNWNWKSRVNDAEFGLNGELLSDHRPLPSKADIESRWQILQDIINADGPPVYLEAALRQLVSSRWTWEKRQRRPPLQFKSLPNSRPFNLAQTTDPIPVPTEEHRETFKLLSWLAIMFDTISAAMLQRPVVVSDEDCKIETSDPWRSDHSGDTQKSDGAGQNSVNIFDLDGWAPDSLPDARRDGISSDLWGTLFLEKSKSRTFSCFDQDQLHFSLGEASTILCDAAPVKVLLFRKVGRIQKLMSRRASGEDLELAVDEALGVYAFWNDTYGKFISYCIANHHDLPPRIQSWYIVLAGHWHLGAMLLADAVEEMDQAGLSHMFQRNMRRTSDFSNSLRRSNAITVSELGRCSLHGPSLSFPKAREFSYPVNQVALLSEPWTVVLIQSFSRAGYIFIRYLMSWDQWTDKLWSNEDDERYQLRKRCSYCIEGLLNLANKSDMAFLAAKFLQDCLRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXL3</accession>
    <name>A0A0D2AXL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231416.1">
        <property type="nucleotide sequence ID" value="XM_016384814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXL3"/>
    <dbReference type="STRING" id="91928.A0A0D2AXL3"/>
    <dbReference type="ESTHER" id="9euro-a0a0d2axl3">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="27337583"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10500"/>
    <dbReference type="HOGENOM" id="CLU_006586_17_1_1"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="11"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="561" mass="62334" checksum="9D047276ADD4843E" modified="2015-04-29" version="1">MGATQSSIQPHILQTERGKLRGLEFTAAQTGEPVYRRYTRVPYAQPPVGDLRWRRPQPLPERWSFNDTSGAPGDYTQFGPVCPQPTSSHTLALVDNKSAAPPISNVEDEDCLYLNIWVPAGKPPEGGWPVQFQIHGGWLQVGNASQTHDHDPFDLFVHSRPRIVVAPTYRLNVFGFLAGRDLSAAIPEAMSGNFGLWDQRAALEWTHANISLFSGDPDNIAVGGLSAGSYSALLQLHHDTYLPADRRIIKRVYLWSNAIAIQPHSTNSTFLTEQFASLCRVHDISLGLSAPEKVALLRRIPAAELIASFSRLKYHTFRASTDDAFVSSTFLSSLHSGRFTSKLAEHDVSIVLGDVLDEHALYALSKPVTDFSDLVVQLENYYPHAVARALVRAHGVSEETHRSDSAAWTEAFGRMVADGQVHASVRGLTHLLLHPPAPHSGLPASNVHRYRIEYRWKDSGRWIRPGLSVCHASDIPIWWASGFRAGFSPEERAAALQFLEPFDRFLYGEEDVRWGGAGGEDRVRLLDRRGHVVEGSTDRDWARGLAVWEAIWNAQKEQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AY46</accession>
    <name>A0A0D2AY46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribonuclease T2-like</fullName>
            <ecNumber evidence="4">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_10650</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231566.1">
        <property type="nucleotide sequence ID" value="XM_016384964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AY46"/>
    <dbReference type="GeneID" id="27337733"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10650"/>
    <dbReference type="HOGENOM" id="CLU_037966_0_1_1"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249273" description="Ribonuclease T2-like" evidence="15">
        <location>
            <begin position="21"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="16">
        <location>
            <begin position="449"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="333"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="407"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW11350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="568" mass="60889" checksum="5E86BF703E0EED37" modified="2015-04-29" version="1">MAPSLIQLPFISSLLHLLPGTPPETTSTAISTTTVQSCPNPPSLSCPFPPPREINTCCVNHPSGHFLQTQFWDTSPALGPNTSWTIHGLWPDLCTGGFDEFCDSTRSHPPGAMRELITTLLNHTHSDSSTALLDFMDEYWLSLNSDPAHLWAHEWNKHGTCVSTLEPGCYPEEALSGDHVSEGDGSGTITGGGSSSIGGDSGGDLDLGILDYFIHTTSLFRTLDTHAILSEAGIVPSRDVRYTLQDLEDAVSSSPHGHAVTFRCTHSGELNEIWYHFSVKGPLRNAYARDDDALATTTTTTSSSPAPPHQHHLHDSNSLPFLPAETVREIFVPTDPDGAKSNCPASGIKYLPKNDKSPDNPGPSPPTRTSTVTATSTPTSTSPPFTGKGHLAIHVLDDASSLTSTSISATHDDSAADDSVRAPAAQNQKSLAAPVAPRAPSSLSENPPSDQNLGCLIRLGQWYVSGTCATFTAQSDVVDPGHAPLFSLSSSYSPCLIDRATARFECTKSTSVQSIFSSDPQNPHVLSYQNKTTFYADHVPKRFDKVDVYADDADGARSVRLEIHWIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZ15</accession>
    <name>A0A0D2AZ15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_09211</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="4"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232154.1">
        <property type="nucleotide sequence ID" value="XM_016383531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZ15"/>
    <dbReference type="STRING" id="91928.A0A0D2AZ15"/>
    <dbReference type="GeneID" id="27336294"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09211"/>
    <dbReference type="HOGENOM" id="CLU_006587_3_1_1"/>
    <dbReference type="OrthoDB" id="5295093at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="15">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="14">
        <location>
            <begin position="296"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW11938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="485" mass="52721" checksum="AA73153F83BD396A" modified="2015-04-29" version="1">MSAKSILEADGKAILNYHLTRAPVVKPTPLKPSGVHNPPAKLASLYFPEDESVKTVLDQAEATYPWLLAQGAKFVAKPDQLIKRRGKSGLLALNKTWPEARAWIEARAGKEQKVETVTGVLRQFLVEPFVPHPQDTEYYININSVRDGDWILFTHEGGVDVGDVDAKAEKVLIPVDLKEFPSNQELATALLKKVPKGVHNVLLDFIVRLYSVYVDCQFTYLEINPLVVIPNAAGTSADVHFLDLAAKLDQTADFECGTKWAIARSPAALGLPGTKTDGKVTIDVGPPMEFPAPFGRELSKEEKYIADMDAKTGASLKLTVLNSQGRIWTLVAGGGASVVYADAIASAGFVSELANYGEYSGAPSETQTYNYARTVLDLMLRAPLHLDGKVLFIGGGIANFTNVASTFKGVIRALREVAPILNDHKVQIWVRRAGPNYQEGLKNIKAVGEELKLNMHVYGPEMHVSGIVPLALLGKKSTIPEFGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZS3</accession>
    <name>A0A0D2AZS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major royal jelly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232449.1">
        <property type="nucleotide sequence ID" value="XM_016383826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZS3"/>
    <dbReference type="STRING" id="91928.A0A0D2AZS3"/>
    <dbReference type="GeneID" id="27336592"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09509"/>
    <dbReference type="HOGENOM" id="CLU_031076_0_0_1"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="44075" checksum="0A229877E6474325" modified="2015-04-29" version="1">MKAKSLRDLVWPERTYATNLTTALNAADKTIIDDEALRFILPRPGGPLDLAALSTSAAEDPRLKVALTLQNPVNGVSTAPDGRLFVLYARVDGSTGPQVAEWHNDSNPTPYPNAEWNSYGPGKDPATHLIRTNSQRIGPDGTLWLVDTGSPGIGEPVILPKGPKLVQVNLTTNKVTRVYNLGNVTLTTSIIDDLRFNPSAGLAYITDAGAPAIIVLDLATGEARRLLEDDPTTKGFMPVSAEGGLLRGPTGGYFYIYADQHEVSPDGKHYYYQPCAGGLSRIETRYLNDAFYNSTLASVLSRYPEPYALTPSTGGTAIDAEGNIYNSDTNRQAILKISPNGTSTILVQDPRLLWVDAMWIDTYGQLWIPAAQLNRGIPFNNGSNHIQKPLYVYTIDIGVGPSPIDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B026</accession>
    <name>A0A0D2B026_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232231.1">
        <property type="nucleotide sequence ID" value="XM_016383608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B026"/>
    <dbReference type="GeneID" id="27336372"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09289"/>
    <dbReference type="HOGENOM" id="CLU_166315_0_0_1"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="11207" checksum="2AD8427BA45BC55D" modified="2015-04-29" version="1">MSSDRSSSDSSQSQASLLGGHAKYVQGAVSSALGYESGQQTKDAAVEEMREATKKTNSAGQQPGAPAAQSTVLGTVEKTAGQVTGCEGMVEDGKDRIPRKVGVEETDGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0M8</accession>
    <name>A0A0D2B0M8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_09541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232481.1">
        <property type="nucleotide sequence ID" value="XM_016383858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0M8"/>
    <dbReference type="STRING" id="91928.A0A0D2B0M8"/>
    <dbReference type="GeneID" id="27336624"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09541"/>
    <dbReference type="HOGENOM" id="CLU_002741_2_0_1"/>
    <dbReference type="OrthoDB" id="5559898at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="738"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW12265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="964" mass="105613" checksum="66AB39A222EC7071" modified="2015-04-29" version="1">MAFSSQGATTMLQPLTDLHAATDPAAVSQVLKKIKYELSGHSSRKADFVHNGLIHLLDKSLAGLVVTPRTDENELTLTHTAQVLCVIAHEGPSFVQPILETDILQSLLRCLLQPLASKTVLTILRCLNAVAENMPPSSPGQWPQDGRLADLLYSKQYIQSTTRVVGIAGETLASQQACDAMLALLAKTLSSEQHKRALVDNGMLTILAARLASFVVSEGLVPPDTEALDSDNGDVSILPDPAPSFAHLSPVLETICLFIERSSDRAATFLTDPSIKAVFPDIKDDFAPSDIRRAPSGAAYFSGGAVPRSRPQGPFDALLPLTLVLEKSNSPFPPLPPLGSTAAIPKRRASFHPATPTFQQPSPEQDPDDLEESSVISWLLYMVRASKGKRRMLAAKLLVNLYSLNFVKKERGTSFASLLVPILTRMLEVDVLKSDSLQQGSGVYLGNGLHYAKEVPAVLAVLIMDDPAMQTVAVEGRAIVNLSTGLKSTFEGPSGRKQKPWQPRKAHGSHADVSIPAAKLGGPAPSPAVRREMEYRKGCLQALAAIAPFDDDYRRAICDQGVLHYLVLSLELYQIENIDDPEMEITGNSAPVIMAACGIVRVLTRSVKALRTKIIEAEVTKPIIKLMNSTNPEVRIAATQVLANLAIDFSPVKESVGDPNVVKKLCEQAHSANARLRFESLWALKQLVCNSSRKLKQDVVDELGPSWIKLLIKTNPGDIPEGEVIGLVERDYPPLSGYQRASSGTEKTNDIVMSGGFGDSRRLPPGRSVGDAGLDQTGFDMRHTPEDDTEIQAQVLDLLRNLFCGDNASELVKYIFDEWGQDEFFRIMLDRLRPRTLAGPTRKENSSTPAPTTIVIKVLYILAHIGACETKWRNLITSQQALMKQVLSFSGHEDREIRAQVCWISINLTYEDDMSERAACRQRAQDLQRYGYVTHMRKLEDDADINVRERAKTALHLLSKLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B208</accession>
    <name>A0A0D2B208_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233149.1">
        <property type="nucleotide sequence ID" value="XM_016382446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B208"/>
    <dbReference type="GeneID" id="27335203"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08120"/>
    <dbReference type="HOGENOM" id="CLU_794607_0_0_1"/>
    <dbReference type="OrthoDB" id="4138367at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38437" checksum="F4569FEF3F6D7C4F" modified="2015-04-29" version="1">MDPATAISTAAAVIDLVIFGYKVIACAVELRSSAQGALEENIDRETIARDIQYVLGNLHGSNEADGDRELEDLRQRALKVATELSIELNKLKVTPNGSKQEALKKALRSLWKRKDILNLEDRLRGLSQEINLHLTTDANKLLNEMTEAQRSQVTKILDEIEQQSKELRAQLIDQQAKNREETHLLRQSVDAVKEETASIRESLDKVVDGSQGTKIILEQILEAGADLQDRFKRVEELLAQPEPNQSELTTGAVNQVFEALAWYCNRKTAADVLLQQKSDETASAFPVTGHVYTASVQVRGRGKLVQGNIGPAQKHDAKHTFGGSMNVTDDAKVVSGNISELGFAASFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2P4</accession>
    <name>A0A0D2B2P4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233101.1">
        <property type="nucleotide sequence ID" value="XM_016382398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2P4"/>
    <dbReference type="STRING" id="91928.A0A0D2B2P4"/>
    <dbReference type="GeneID" id="27335155"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08072"/>
    <dbReference type="HOGENOM" id="CLU_033726_1_0_1"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="30220" checksum="C8D67C491317C582" modified="2015-04-29" version="1">MTDRRKRGRPRIDSKFDNWFGVEDARERKRIQDRLAQRARRSRMVSRQDGNSVTKTETECTGETRLQQPIQHDAGLLNGLDTSPPTQDEEHSNNHESLALVPGSEKKNILSAVTSPLLNDSHRWRCSIDVLSRDHQLLCWQAWPIYWALGRHAEMQGTGCPDGGIKARSPPEYLELPEFLRPTPLQMAMPHVRWIDRFPFPRLRDNMILLDGLIDLDEFVRDLWTMANLVLRPQTQKATWDPACWMMGPEFSSKWGYLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3S3</accession>
    <name>A0A0D2B3S3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233734.1">
        <property type="nucleotide sequence ID" value="XM_016383031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3S3"/>
    <dbReference type="STRING" id="91928.A0A0D2B3S3"/>
    <dbReference type="GeneID" id="27335789"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08706"/>
    <dbReference type="HOGENOM" id="CLU_030671_1_0_1"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40428" checksum="68C2F98879A3DDA6" modified="2015-04-29" version="1">MVDSLSQAGRRLGQIKDSLLGKTATTIPFDPDSTSFPTRKNLPKIVGAPDEAAWVWGKDDYIGRLNLLTPTRVRAAASEIRTGEMARLDLPLNVPEQPAFDRQKFEHKILTIADGVAYDDVYHCNTQSGTQWDGFRHFAHIPTNTFYNDTHASDIVGETANHKCSVHHWSTHGFSGRGILLDYRSYADAHGIKYDTATSHAISYDELAACGKWQGIDIRPASQGGDVKIGDIILIRSGWVQDYYNRSPEERNALALRGHGTHGGEQAWAGIKQEEAMKDWLHDCYFAAVGGDAPSFERWPTPETYYLHEYILALWGMPLGEMLDLEKLSDLAKKNKRWTFFFSSAPANMPGGVSSHVNATAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3S8</accession>
    <name>A0A0D2B3S8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233551.1">
        <property type="nucleotide sequence ID" value="XM_016382848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3S8"/>
    <dbReference type="STRING" id="91928.A0A0D2B3S8"/>
    <dbReference type="GeneID" id="27335606"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08523"/>
    <dbReference type="HOGENOM" id="CLU_045518_0_1_1"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="304" mass="32977" checksum="FCA49A18378F1B0C" modified="2015-04-29" version="1">MPTALTTGATGLLGRQVLKAFEDADWHAVGTGFSRASGAIRKVDITDSGSVAALFNQVKPDVVVHCAADRQPDSCTKNPAAARALNVTATQTLVEAFHGSLFIYISTDYVFPGAAGDAPYKPTDAPNPTNIYGQTKADGENVVLAHGPNAVVLRVPLLYGPGENSESAVNTLMDALYKTGGTVKMDDWALRYPTNTEDVARVCVDLARKRIDQKEQSAIAIPHILQFSSEDKMTKYEICQKFSEIMGLPMDHIVPDKDGGKPKDGTMRPYDTHMDTSGLKDLGVDVSTVDFVAWWRRYVGAFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4Q7</accession>
    <name>A0A0D2B4Q7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_06689</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234124.1">
        <property type="nucleotide sequence ID" value="XM_016381022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4Q7"/>
    <dbReference type="STRING" id="91928.A0A0D2B4Q7"/>
    <dbReference type="GeneID" id="27333772"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06689"/>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_1"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="110"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW13908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="509" mass="55769" checksum="3B1451E22409FBB6" modified="2015-04-29" version="1">MSGPALARQACRVCSRRPSTSILAAHPRPIIAAPRLYSRNYVSQSKPSQAQVADVESAIKADQKKFIQQSGNLPSQTKMPGTEISGDTAMSPAAGILKQATVMDQGSRPIYLDAQATTPVDPRVLDAMLPFLTGLYGNPHSRTHAYGWESEKAAEQAREHIAKLIGADPKEIIFTSGATESNNMSIKGVARFFGRSGKKKHIITSQTEHKCVLDSCRHLQDEGFEVTYLPVDSSGLINMQQLEDAIRPETALVSIMTVNNEIGVIQPVEEIGKLCRKKKVYFHTDGAQAVGKIPIDVNKWNVDLMSISSHKIYGPKGIGACYVRRRPRVRLDPIISGGGQERGLRSGTLAPHLVVGFGEACRIAKEEMEYDSKRISFLSKRLTDGLLSLEHTSLNGDPTRRYPGCVNVSFAYVEGESLLMALKDIALSSGSACTSASLEPSYVLRALGNSDESAHSSIRFGIGRFTTTSEIDYVLKAVRERVTFLRELSPLWELVQEGIDLNTIEWSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5V6</accession>
    <name>A0A0D2B5V6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234251.1">
        <property type="nucleotide sequence ID" value="XM_016381149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5V6"/>
    <dbReference type="STRING" id="91928.A0A0D2B5V6"/>
    <dbReference type="GeneID" id="27333899"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06816"/>
    <dbReference type="HOGENOM" id="CLU_005788_0_0_1"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="799"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1089" mass="119058" checksum="7C39C8A22CD6FF6C" modified="2015-04-29" version="1">MSVLPSTTYQSPPRLARGRQLNTIIEEKEDGSQGVKSDSEGDGSDSTIIGRPAAWNPQLFTVAPRKSSLATTTYAASPVSSCEPSPASSASDGFPRNSVRSSSSDSEAGTVFSDDCPSLASDPTTFASESSRSSCSSTRSSRNRYPALIIPRDSWGTVDSSPIKEIAYGMSPATKIRLSPTTLSALSRSVPAANAPPSLGDSNSTASESPCVQGLSAPVTPDLRQLEVEQGSSWGVSPSAPAVHAQHLEIALDDGHSVIFSPAEAHSNHSFSNILSPTATAWTEMVVSFPQVPGATPQDISPLMPTLDELKTFEEVKPRSNGSDPGVRLPPDALQILQRLAGNGSAENLSTSSGSGSGSSKKPGRRQEMRELLDPHLINRPRSADGETPISDYSFTQLSIPSPGGFFSSLQSGSRHTWCLNKSRAPSIPNTATAETFYNRPWDNSSSSNEVETVLDVDDTNLTEGPPTARQALFDINTSPKGQKAKSRGSEDDDLYGPGDDVKPPQDPRKASFEYDEKYFDELKHNASRNLHLTGSWLAAQTGYLSAILDSDPNDNQDEKKGGEEEKAKPDLAARRTVMFSDNVNVDAAVAVAPSKKQLSSTEPDTKEAVFLNAFRYMLSNRKRRDAFIHASSRLEAIQAFRVALPEQHITNLLGQHILLEHKRPKYAGPFSQNPRATGIFEQTSEQIAFKTAEREQLALASIEPSSWQIDALRTMYGGRLLASAAACQRLKTKSTIPLDHPNCVGSKRIRILDIGGTSCASWAWHAALEWPNVKIYTVITKEQSQSQRPQGKPKPEAPKNHRTVSVPHLWQLPFRSGHFDVISARSLHVLLKHNPVPGVPEIDEWDLALRECQRVLKPGGFIDYMIMDSTIAHAGPRGDAMSVEFGFELHRRGYEREAARSWLRRVKKEGFTGVKRAWVFVPMGRKPPKEVEESVHGYIGGWHSWRQGAKPFVPAPRPISEVSTISKIVKQYMDVEAVQGPVGSTEDVADLTGLLGARMWEEWLVKVRAESGREQARWLEGVDEMIEEGKEYGSGWKLLIGWARKPMPEKGKKAERAEITVAVEDLEELSPTSEECTEMGMIPMVIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6Q3</accession>
    <name>A0A0D2B6Q3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_07337</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234769.1">
        <property type="nucleotide sequence ID" value="XM_016381667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6Q3"/>
    <dbReference type="STRING" id="91928.A0A0D2B6Q3"/>
    <dbReference type="GeneID" id="27334420"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07337"/>
    <dbReference type="HOGENOM" id="CLU_022045_1_1_1"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW14553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="531" mass="59924" checksum="1E0B378DD583D7C7" modified="2015-04-29" version="1">MAAVLSTTLNRFRDKTPIVPELRQPRSKGQPGINQWPSLFQTAVVATALKILLFPAYKSTDFEVHRNWLAITNSLPVRGWYYETTSEWTLDYPPAFAAFEWLLSQPARVIDPAMVLIQNLNYDSWATVCFQRSSVIFTELLLVYALHRYTETSPLSTRRQSHAVALSILLSPGLLIIDHIHFQYNGFLYGVLILSIVLARRDSTMLYSGILFAVLLCLKHIYLYLAPAYFVYLARAYCLSPKSMFRPQFTNILKLGTSMVVIFGAAFGPFAAWGQLDQLKSRLFPFARGLCHAYWAPNAWAVYSFLDRVLIVAAPYLGLNVDQKAVNSVTRGLVGDTTFAVLPDISASQCFAITLSFQIIALTKLWFRPSWDSFVGSITLCGYASFLFGWHVHEKAILLVIIPFSLLAIKDRSYLASFRPLAVAGHVSLFPLLFTAAEFPIKAAYTISWLIIFLYAFDQLAPAPSRRRIFFLDRFALLYIAVSVPLMAYCSLVHKMVFGARYEFLPLMFISTYSAVGVIGSWLGFMVCYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7I2</accession>
    <name>A0A0D2B7I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235094.1">
        <property type="nucleotide sequence ID" value="XM_016381992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7I2"/>
    <dbReference type="STRING" id="91928.A0A0D2B7I2"/>
    <dbReference type="GeneID" id="27334746"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07663"/>
    <dbReference type="HOGENOM" id="CLU_037990_6_1_1"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="30664" checksum="66808D0B1686038A" modified="2015-04-29" version="1">MSQQPPLTARLYGLLDPLLLISGSAKAFTKHAFQTFILQGTFPTPSAVFRVRDESFSKWWTKATAPIDPPPPPVGSSALVAPILSHAHGVVLDIGPGTGPHVSAFSDNANITAIYGAEPAVGLHPALQDRIDKAGLTARYHILSCTADKKDLLAALAKQGLASAAAGDRDRDGLFDTIVCVRVLCSVPDPDQAARDLYSLLRPGGELMVVEHVKNPWTTANGSVLGRAMQILCTLIGWQFFLAGCSLIRDTASYLKNAGKWEAVNIKWNFPWAPLPYVSGTLTKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B816</accession>
    <name>A0A0D2B816_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235046.1">
        <property type="nucleotide sequence ID" value="XM_016381944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B816"/>
    <dbReference type="GeneID" id="27334698"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07615"/>
    <dbReference type="HOGENOM" id="CLU_020820_0_0_1"/>
    <dbReference type="OrthoDB" id="3596604at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="728" mass="80750" checksum="D837B754DFC9DE8B" modified="2015-04-29" version="1">MMEKFGLHSAASGGQYEPPTAASDSPSPLTWSDTIYSTDSPNSPTTKSQRALPRIATRYRQPWRHSVSRALSEEVASPTVREFNPSRQRWRLFVKAMYRWATTAIMCGLLATCLGVFGNLLKMSVGQVKLFNALIVLLSLFTGNNLASTLREFALMFRWRLLASKYRSLEEFDLIMSCDSLRKVISLFRTARTPGRLFFRLNRTQCLCAVWLGINMCLQVLIALLGVTYNLGTSTHPGLKFGKLSVANLTQINDIWSADNPNIAAQMGSANTYGIQGQDYIFVDGPVPGQTGPWEFGSPSTPTIYGNGVNWTSMTYAFQDENPTNAAITLISHRTITIEATCTALELVDVSDLEAGYSNDTGTETISYVDERGALKFLDLQPGEPGAVTYIGVLNATCGPRCSQVMALQNASAPHIPRPSFYTCNSTLTPVQGVQEYLHAGTEQTELTFQIRDEQARIIAGAIGWSMSGIDYSDPADDDNQLAYEMSRYTQSSWWSPAHPMTAYWVEQRVMEYAIEAVAAMDYNGPQQNVTGWYPVLAQAVTVEWPWAGTILVLVPVLQLVASVCVIVWSNTAIIRDQSALSAARLLRPVVEGLGAKGCLLSGEEIAAMFPGVKVKYGWREPQDLTFRNEIDPASSSVRHVDILQEQEGYSTQGPMPAGFYDGEPSDHEDDDDDDDDDDDEGYNCFNDEKSRHVFKTAAMNEKTASRHEYRPGKARRRTRPRTRRMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B869</accession>
    <name>A0A0D2B869_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235304.1">
        <property type="nucleotide sequence ID" value="XM_016382202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B869"/>
    <dbReference type="STRING" id="91928.A0A0D2B869"/>
    <dbReference type="GeneID" id="27334958"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07875"/>
    <dbReference type="HOGENOM" id="CLU_016665_3_0_1"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="201"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="470" mass="53555" checksum="0AC58C5607A89F68" modified="2015-04-29" version="1">MPVPPGHHGNLTPEQEKKLQELWAATLKVFGVVEPTELTDAPVTKLESRATDLDGKDKKKSKRRLGVFKRHGDKKDSSNGSTTPSKDNADDDKYGQVKEFQEILATQDPELLRRTFWSMVKADHPDALLLRFLRARKWDVDKALVMLISTMRWRSQEQHVDDDVVLRGEGGALEDSSSSDPAVKREGVDFLTQLRLGKSFLHGTDKEGRPICFVRVRLHRGGEQTEKSLERYTVYVIETARLALRPPVETACILFDMSHFTMANMDYTPVKFMIKIFEANYPESLGAVLVHKAPWLFQGIWKIIRGWLDPVVAGKVHFTSDVSDLEKFIPKSQIIKELEGDEDWEYKYVEPIPGENDAMKEEGPRKQFEAQRETTVEEYQKKTFEWIACGASGSSEKIKQERDGLATKLHENYWQLDKYVRARTYYDRTGMISPDGKINFYPPPPGTGENQNLVPTSQAPAVETHADDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8D4</accession>
    <name>A0A0D2B8D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_07712</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235141.1">
        <property type="nucleotide sequence ID" value="XM_016382039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8D4"/>
    <dbReference type="STRING" id="91928.A0A0D2B8D4"/>
    <dbReference type="GeneID" id="27334795"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07712"/>
    <dbReference type="HOGENOM" id="CLU_022195_9_2_1"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254287" description="Cytochrome P450" evidence="11">
        <location>
            <begin position="27"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW14925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="59956" checksum="EE293D3EF2EEC299" modified="2015-04-29" version="1">MIGPANPLLLLTIGFVVVLFLRSRKSSKKALPDVPWINTHDGEFLTRIRARFRTTFNYKEAIYQAYEQCSKRDRPCIIADINGEEIIMPISAMSWFISQPDSVLSADEMHRDVLQIDHTFVHPFIVERPLHHETVRIDLTRQLGALTSDIMDELSTCFDEYWGTDTENFKELCVMDSVMQIIARTSNRALVGLPACRNQTLLEHGKGFATSIAISSALLKQMPAFLRPLLSPLITLPNRRHTRGFAKILTPEIQRRQRLFAEGSDDEKEMGEVEPNDFLQWSIRRAQECGSSVENDPSIIAERTLAVNFAAIHTSTFSITNIIFDLVSSDPSMQYMDILRNEVASVLAEENGNWSKQGLAKMVKLDSALRESSRLGSFVGALSRLCVSPQGATAPDGTFLPYGSTISVPTTPVQNDPMLYANASAFDPFRFSSQREALSTGGPGDEDNTTTSNPSAYLEKANLSFVSTSPSYHPFGHGRHACPGRFFAANELKLLLAYMLLNYEFEMLPTRPKNIWMGRTHLPPMKATVKIRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAQ8</accession>
    <name>A0A0D2BAQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236234.1">
        <property type="nucleotide sequence ID" value="XM_016380407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAQ8"/>
    <dbReference type="STRING" id="91928.A0A0D2BAQ8"/>
    <dbReference type="GeneID" id="27333152"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06069"/>
    <dbReference type="HOGENOM" id="CLU_036838_2_0_1"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02651">
        <property type="entry name" value="nuc_hydro_IU_UC_XIUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="365" mass="39459" checksum="9DF2CF1BF79F3B8C" modified="2015-04-29" version="1">MPFDKIPLWLDCDPGYSHSQDACAILMAAYHPCFELLGISTVHGNASLQKCTNNALSVLEAIGKPEIPVVPGASRPFCRTVNTAPDIHGESGLAGTSLLPQPSRVALSHCNAVKEMRDALLAKPKGTSYLVTCGPLTNAALLFATFPEVAEHIAGFSAMGGAIGSNFTNVSMGPAYLDPQGVSHDRSGNMTPFAEFNIWVDPEAARSILQNPVLQPKTILIPLDLTHQAYATPEVQKMLLNHGNPSRLRVMFNELLMFFAQTYAQVFGLTEGPPLHDPLAVAVLLDQHPDEDARIAFDDKGGERWDVDVILEGEQVGRTTITKAPSGQGVRIPRSLDADKFWHVLEYCMGRADEATNFGKATTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBG2</accession>
    <name>A0A0D2BBG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236564.1">
        <property type="nucleotide sequence ID" value="XM_016380737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBG2"/>
    <dbReference type="STRING" id="91928.A0A0D2BBG2"/>
    <dbReference type="GeneID" id="27333482"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06399"/>
    <dbReference type="HOGENOM" id="CLU_021768_5_1_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="297" mass="34438" checksum="815D1F3647C42DC6" modified="2015-04-29" version="1">MWNPPPLPYFCDSSLVPASLPSTADIENATSVLKDGSSRVLRVGDHFVVKYGPQIRRRIQEGLNTIFVNQNLTTPSPLVYALYEEKGNAYLVMQYVAGQSLEQLWPGLQDRERRLILRKLRTVLDDMRSLTPPSPLFYGSVDRGPLPYFLFWTPKPQEMINGPFDTEEQLYLGLVEQLRQIYSDNNQHMSRVEWLRKHLPVSLKGHPPTFTHGDIQKKNILVDKIGKGQDDFRNEDDFSLTIVDWEDAGWYPSYFEYFISYTSFLWDDDWPQLLEICLDAFPLQIAMLSPIYHGIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBS6</accession>
    <name>A0A0D2BBS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_06101</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236266.1">
        <property type="nucleotide sequence ID" value="XM_016380439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBS6"/>
    <dbReference type="STRING" id="91928.A0A0D2BBS6"/>
    <dbReference type="GeneID" id="27333184"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06101"/>
    <dbReference type="HOGENOM" id="CLU_020279_2_0_1"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW16050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="602" mass="67625" checksum="11FA3437D7C5427A" modified="2015-04-29" version="1">MPTISVDKAALFKALGRDYTTEEFDELCFDFGIELDEDTSLTERPIVDGVQEPPQLKIEIPANRYDMLCFEGIQLMLNIFNRKVEAPKYVLKAPPQGELQTITVKKDTARIRPYVSGAVLRNIKFDQARYASFIDFQDKLHQNLARQRTLVSIGTHDLDTIKGPFTYEALPPKDIKFAPLNQTTEMNGEQLMDFYDKDKHLGKYLHIIRDSPVYPVIYDSNRDVCSLPPIINGNLSKITLDTKNVFIEVTATDKTKLEIVVNIVVAMFSQYTAEPFTVEPIQIVSEHNGESRQVPDLTPRATQAELDYINGCSGLSLSAQDVCTLLTRMSYTARPSKSNPNLIDVDVPITRADVLHQADIMEDVCIAYGFNKLPRAFPKVGATVAAPLAVNKLSDILRLEAAMAGWAEVLPLILCSHNENFGWLNRKDDGKTAVRLANPKTAEYQVVRTTLLPGLLKTIRENKHHSLPMKIFEVSDVAFKDESLERKSRNERHFAAAWYGKTSGFEVVHGLLDRVMAMLQTAFITHEEGLEIKNGNAKGMQYWIEELDDPTYFAGHGASIHANIGGKDIVIGTFGILHPTVLEKFELKYPVSTLEFNVEVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBZ6</accession>
    <name>A0A0D2BBZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_06191</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236356.1">
        <property type="nucleotide sequence ID" value="XM_016380529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBZ6"/>
    <dbReference type="STRING" id="91928.A0A0D2BBZ6"/>
    <dbReference type="GeneID" id="27333274"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06191"/>
    <dbReference type="HOGENOM" id="CLU_035750_3_0_1"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="12">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW16140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="281" mass="30326" checksum="755633604942A641" modified="2015-04-29" version="1">MPGFDFSNYNRNAALHVRGVPLPKATSTGTTIVGCIYDNGVVIAADTRATSGPIVADKNCEKLHYISPNIWCAGAGTAADTEFTTALISSNLELHSLSTGRTPRVVTVMTLLKQHLFRYQGHIGAYLVVAGVDPTGVGLFTVHAHGSTDKLPYVTMGSGSLAAMAVFESTWKKNMTKDEAVKICSEAILAGIFNDLGSGSNVDVCVIEKDKPTQLLRNYIKPNERVKKERNYRFARGTTAVLNEKVITKEDIGRYVTVHEIGSGSDSDSLVVVEKMDVDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BD26</accession>
    <name>A0A0D2BD26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_04063</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237089.1">
        <property type="nucleotide sequence ID" value="XM_016378412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BD26"/>
    <dbReference type="STRING" id="91928.A0A0D2BD26"/>
    <dbReference type="GeneID" id="27331146"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04063"/>
    <dbReference type="HOGENOM" id="CLU_009646_8_1_1"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="256"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="665" mass="73032" checksum="525CD3F059B7E1CE" modified="2015-04-29" version="1">MSQRPKQAPTSWAAYERGRASSFDSLNSVPENEPQTSFSPSTPPRYEYGRGSSQDDDEDGPRLRRKSSLGKKFDSLRQMGGPNSIDNFAKSFQRAAGFREITPIRRNSVTIQDGQDEETGAPSQSTSKAPDRSLLRRQLQDYDLSSQNETAVQEGTDAPTEQSRLLPVTSQRSLKSTSDSIATDLRLPSVLGTSYGSISSRLTVTARQRASILIQAQEEASKRALQHPEEFQDEPQRFLEREVLPDGEVIERTVGESTVPMTIFNSINVLIGVGILALPLGIRYAGWVLGLIFLTLAALSTCYTAKLLAKCLDTNSASTTYGDIAFLALGSWGRNFVEALFILELTAANVALVILFGDSMNSLFPAIGVTDWKIIISLGLIPLNFVPFKMLSISSVIGIFCCFGIIAIVFADGLIKPHAPGSLREVAKTYAFPENWRTIPLSLGLFMAPWGGHSVFPAVYKDMRHPHKYGRALRYTYFFTYGLDLSMAVLGYLMFGDGVRDEVTSNILRSTAYPHALSAIIVVLIGIIPITKIPLSNRPMMDTLNKKFYIDLRQMDPKARMHSEKSLKHRAARGVIGILTNLLQLGIAIGFPDFDSIMALMGSGLCFTICIILPVSFYLKIFNAESAVDTIERVLGWILVAVCVVLAVLGTVFAILPKEKIGISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDC2</accession>
    <name>A0A0D2BDC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237159.1">
        <property type="nucleotide sequence ID" value="XM_016378482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDC2"/>
    <dbReference type="STRING" id="91928.A0A0D2BDC2"/>
    <dbReference type="GeneID" id="27331216"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04133"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF67">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="332" mass="36608" checksum="F41FAF72DB2F959E" modified="2015-04-29" version="1">MGGILTQRFVRLPYPTTSFSGQTVIVTGSNTGLGKEAARHFARLGAAKIILAVRNTDAGTAAKQDIESTTHCDPSVIEVWHLDLASYESVRAFARRATADLARVDVLMENAGVAKLTWDVVEGHERTITVNVLSTFLLAFLMLPKLRATAEKFETTPTLTVVSSEVHAMTKFPEWNDPDHANTFDALDDQSKTNFRERYPTSKLLEVLVIRAMVDRMRKREKKGRTEKQPAVTVNYLNPGLCHSELAREGGLRFTVLKFLFARSTEVGSRTLLAAAAAGPGSHGRYMTDAEVDDGALSSFVRSEDGKRASEKVWRELVEILEKAEPGVTDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE10</accession>
    <name>A0A0D2BE10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_04025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237051.1">
        <property type="nucleotide sequence ID" value="XM_016378374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE10"/>
    <dbReference type="GeneID" id="27331108"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04025"/>
    <dbReference type="HOGENOM" id="CLU_2346698_0_0_1"/>
    <dbReference type="OrthoDB" id="5230585at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="97" mass="10830" checksum="93B16131AA2D4034" modified="2015-04-29" version="1">MVSYIYCGDRERSLRDSQLSSDETTGEAAEVSSRILSTYHAGEPLFSKEIIRDVARQLANTECRKVSVRGLDGQVVEIDVETGNVLDTGNPEWDYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BED6</accession>
    <name>A0A0D2BED6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237574.1">
        <property type="nucleotide sequence ID" value="XM_016378897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BED6"/>
    <dbReference type="STRING" id="91928.A0A0D2BED6"/>
    <dbReference type="GeneID" id="27331633"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04550"/>
    <dbReference type="HOGENOM" id="CLU_027018_2_0_1"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="416" mass="44905" checksum="F29C4D7723DBE1ED" modified="2015-04-29" version="1">MAEPPKNELISSKPSDSGLTVSLHPLVLLTISDHVTRHSVRNQKGPVAGALLGQQTGREITAEHAYPTDLVQNLEGEWEFNILWMESRTQQYRDVHKDPALDFVGWYTLAPESGPLPDFLRLQQQAMTFSGDTTILLVLHPEAVEADGATSGKLPVTVYESAFEAEPPKDDGSMQVDGQENTYLRFKPLPYSIETDETEMIAIDYVAKGAGSAAAVDDSKGPNSSAGSSETKSNDKKGKRRADAVEVNGSGAEDGLDALTPEEQDQIANMTTRLNSVKMLQSRISLMRSFVESLPPSYLTDQESAPITSDSPDAAHLPHLRNIQALITRLSLLTPMDSAASSQPLAEATQAQANDVAMAKLLSLLNQDVQALQDLGRKHATIEGARNAGRAKHTAGGQKAYDALAEGDGQFSRMVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEM1</accession>
    <name>A0A0D2BEM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_04201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237226.1">
        <property type="nucleotide sequence ID" value="XM_016378549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEM1"/>
    <dbReference type="GeneID" id="27331284"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04201"/>
    <dbReference type="HOGENOM" id="CLU_381769_0_0_1"/>
    <dbReference type="OrthoDB" id="4064873at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="764" mass="85022" checksum="E6FCABB275CBD77E" modified="2015-04-29" version="1">MANENCQPQPTRPRKRRRGAGIDEIDNASGTVTEPIRRASRACDQCRLQKKRCDSGHPCDACAKTSLDCRYGQQSKKRGFATGYVHIVEALWALVFKAVPGSQEATLRLLQRSNIGYDDEGKASLFNLQFDAVDSSRKAWLSSSIRHEIDKLVSNLEDTTGDALKDRLQPETGKEGKPSAPLGTNFSPWSIPADGLEDRRSSKRSRKCLDMANINSRARSGTAMPLTALGDIHEPLPPDAWKLIETYFKFSHSWLPITQKHSIVRTLTEVQDGVAHSSRRMGLLWAVLATASMQHHQQQPAREQEHPSISEIYYNEAIKSIPGRSSSLDPDHVKALVQLAVLDIARRRWDAAFLILRRAIRAILHFLRVYQDRPGDNPVDSAFLRTVLAAFSMDTLLAARSGTIPQLRSQEVRLALQYDENEADEWELCSSSHGDSGANIQGHAASSERPLRTLSIFKHYVKLLFILNESVCDLCPFKDDQAKLRDSLDKLGSWKSHLPRHCRQCQAPVVGDNGQQQQQQHVLPAVANLHLTAEAVSLFVRGRQYAYAAGIPCEFSRLESFTESGSMVRSTYQRVFGAVAWSGVLDFHEYSSRLRCKAVNTQMSTASVSDVFGYPDVRDTTSYDCSGIEIFNVDPGPEYTLTNIEAVPPGQCPVTGGLFLSVLDDIMTDQNPQDSDLASTELRMPELHMSAGSFFASFDIPQSDAGRAHSCRENPRAESISDDTSITALLDELSETQNKFDWMENEVPSMSAYNPDFMQGDPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFR0</accession>
    <name>A0A0D2BFR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230420.1">
        <property type="nucleotide sequence ID" value="XM_016385476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFR0"/>
    <dbReference type="GeneID" id="27338248"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11165"/>
    <dbReference type="HOGENOM" id="CLU_119619_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="182" mass="20084" checksum="1EE60CD5A20D914A" modified="2015-04-29" version="1">MSPAMDWVQKHYWTWYEEAKVLLHEEGGGGIEDGKELMLDLLGRVDLGLLLRASVNFSLANASESIVDQVQYSTEALDLAAMLDEKYSDEETELVLQEVTMLVQSIKEKAEQQGVNVEDLKPQQDDTDILWEGYQELKAWRAAKEAPKETDTESASSSDGGDDTADEPQITPAVAASASDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BH35</accession>
    <name>A0A0D2BH35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230875.1">
        <property type="nucleotide sequence ID" value="XM_016385931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BH35"/>
    <dbReference type="GeneID" id="27338706"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11623"/>
    <dbReference type="HOGENOM" id="CLU_1454434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="186" mass="20443" checksum="338E72419A4B3DF8" modified="2015-04-29" version="1">MGSVSGCDIDCPALHWCVGAVLSRSRTTYDEDIENAPFFGKRMVEMLNTFDSTRRIMGSGHLRTYEHVLYIDLYISIGAVLFCAFQVIDINVNVSKDSFDGAATTEPTSESYVNIDFGPERSHFSGFHRFSVIRDQPAAGTDGSIQDVDLRAGGASNRVRIAFSALVCNPSRDQPSGPRILPAFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIC9</accession>
    <name>A0A0D2BIC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238929.1">
        <property type="nucleotide sequence ID" value="XM_016377359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIC9"/>
    <dbReference type="STRING" id="91928.A0A0D2BIC9"/>
    <dbReference type="GeneID" id="27330085"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03002"/>
    <dbReference type="HOGENOM" id="CLU_008002_1_0_1"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="8">
        <location>
            <begin position="68"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="7">
        <location>
            <begin position="198"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="854" mass="96225" checksum="3C15A1953C779836" modified="2015-04-29" version="1">MDSQQYFGQTQPTDQPTTRSIFPRGPVFNLEDFSNRDFIAKDFIEALTESTHVSHRRSQGDTSITFDPKPLIRTFEQASRRLNELSAELEQRENELSGAVRIAEAQHANNTETLGRKLNQTIESFQKLDTSLKSERGEKWGGNVAVETGRRLEELDRQRRRALDAHFLIECWDEVSHRGEVTLLENLRRSGTGEGKIRAASIARQLLRISQRLDSKSQAQPNGVSQSGPVTNGVTGSRNFDTREVIEKFIETLENDMLKLFDDFYRRQNFEEMKNCAIVLQDFNGGASVQAAFVNQHQFFIDRSNLVTEEVGGDQETWVRLSDPDADLPGVEPGLQSLIDDVRVTVQEESGTIRRAFPYPEQVLGKFVQRVFQQSIQQRLELVLEKAESESTLAYLRSLQAARNYISALVEELKAHGLTEHPETVTSQTSLLLDQQLEELFTPYVGGAAYIDKEKHNLQELYKSLLFKFQLFHSRRQKEPRTYLASLRNRGQELLASAREATDAYVKSLDLEKMSPTQKRILLSVAGLKNTDKAQPDVLEFSEEDGRLDVGAAKRMLKWLAEGVRRGLELGGGAETPKDVAALLNLILKNLLESYVEVALEAAADAASTAENAKRDQPDLSYLGNLRSAVHITHLVQSCVTTLLTPLASTSLTTRREMEKSVRAAVSRIEDQINTIDQQTIDGVLNWSARLLTNQNRADFRPRAETEVVSLEQAQTPTCDGVCRFLDMFHETASRSFDGANLDALLTEVAVGFRAQLLQHFTKYQVNRIGGVMLARDMSRYVQLLRSWDLDDSFTASLEVLTELASVFVLLPDALKERLRGPVLGNLGKENLRPYLLKRDDYLEVGMQSLLNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIF2</accession>
    <name>A0A0D2BIF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_10439</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231355.1">
        <property type="nucleotide sequence ID" value="XM_016384753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIF2"/>
    <dbReference type="GeneID" id="27337522"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10439"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="519" mass="56749" checksum="D231CB80431AC03B" modified="2015-04-29" version="1">MTTTTSSRKHLSRFIPHSQTTLLVAIIAVSVVDSVLLGYDSSLMGSLNVMPTYTNYFTLTTATKSLNTAISYVGGSCASFFAGFLVDWAGRKKIILLSAVLTLIGAVIQAAAQNIGMFIAGRFIVGFGMGFAQTSCPTYVAETAPVKYRPLALGLYYACWGVGTLIASGVCYSTQHYSTNWAWRTPSLIQIVPSTLCFFVLIFLPESPRWLIDQDRHDEALEVLAAVNANGDKDAPVVLLQFREISDTIAFEKSKELSFFESFTSKGNRKRLIITATFSIIVMLPGTNIITFYFGTMLEQAGIQDPTTQLEINIILTSWTLVISLLGAWFADSVGRKTLCAISLAGQIVTFYILAGLTAVYGTSSDKSGIYGTIAFIFLYNAAYGYGITPLTVMYPPEVLSYEVRGTGMGLYTLTTKLCGLFVTMVFPFALDAIGWKTYIINASADVVMLVGVLWYWVETRGLTLEEVDKIFDGIKHSDVPDLKAIVDGEMEMGSDVLKKHVIHGINADEEVVVLQKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIM9</accession>
    <name>A0A0D2BIM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239009.1">
        <property type="nucleotide sequence ID" value="XM_016377439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIM9"/>
    <dbReference type="GeneID" id="27330165"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03082"/>
    <dbReference type="HOGENOM" id="CLU_727624_0_0_1"/>
    <dbReference type="OrthoDB" id="4160305at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="369" mass="36931" checksum="E9200078BEEE3976" modified="2015-04-29" version="1">MEGAKATFVGVTQTGTDKPESDGILSLGSSLGADSGKGPAAATPTPDGQRSASSNAGSASAAGSAASASAANTAPTTLLTSASTGSPGGSATASDIISGTATNAASNTSGAVTVSEKSCDSISCSSGLKAAIVVPVVLAAVAGIFLFFFFARRRRRRAAGGVVESEKTPKKKGKKWSRHLRVFSFDAELLMGGRYSSTNSIRSRDPSVRSAGNSSRQGTASIEPSLHSIEEVAPPYRDAISHAQPGSPLQNRPISAAGGVAGDPILRAASTATAPPPYRSVVPDSNPRSTSPVSGGNPFSDSAPVSPIEGSPFNDPPDEQRPALSRGSSLYQSVNTDDGAPSDAGSIQEAQVGRRVSVRGSGTAPSNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIS1</accession>
    <name>A0A0D2BIS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238681.1">
        <property type="nucleotide sequence ID" value="XM_016377111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIS1"/>
    <dbReference type="STRING" id="91928.A0A0D2BIS1"/>
    <dbReference type="GeneID" id="27329836"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02753"/>
    <dbReference type="HOGENOM" id="CLU_018354_9_1_1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW18465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="452" mass="50046" checksum="E9BFEDFC9EA987CD" modified="2015-04-29" version="1">MELSCATFAKGDPEYEAVRSKVVWNGHKPERYPDIIVQPKDTEDVIAVVKYAWQKGMKIGIRSGGHSWTASFLRDGGMLIDVSRLNDITVDPDAGTATVGPGTFGGSLNARLKEHGYMFPGGHCPTVGLGGYLLQGGFGWNSRLYGMGCENVLAVDVVLPDGTLVHADENEHSDLYWAARGAGHGFFGVITRFRLRCHPLPRAIMNSCFWVSTDHLNELISSLDGAKDSFPRHLEVSMFIGHDQQGFPGLSALVRADALAATRAEARSALETVHRLPVLSNSLKAEIFRDGDLDVLLDTVGGVLEVGHPEIVADNTWMNAPIRTVLPQLREMIAALGPAPSHLYFLYWNRKEHKLPDMAFSLEGNVYITYFAYYTDPAEHEEWAKIIAEGIASVADVGVGSQLSDENLLKRPARFMAAENFKRLETIRRKYDPTRRFHGFMGLAEEYKRLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIT0</accession>
    <name>A0A0D2BIT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable 26S proteasome regulatory subunit p27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231480.1">
        <property type="nucleotide sequence ID" value="XM_016384878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIT0"/>
    <dbReference type="STRING" id="91928.A0A0D2BIT0"/>
    <dbReference type="GeneID" id="27337647"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10564"/>
    <dbReference type="HOGENOM" id="CLU_073146_0_0_1"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="6">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="240" mass="26275" checksum="8553FED16A22C9C2" modified="2015-04-29" version="1">MGLPMDPNLAEIHVPSGPTSVQQGQSFEGLSLQQLIARKDDLEAELKALGAVLDSHGVTMQTSLTTFDGYPRSDIDVAQVRVTRARIITLRNDWKDLMDRIEKGLHKHHAEYQASDDYKNSLLQPEEQQATPQATSSQPQQSSSVPETPFAKVNSVEPGSPAHEAGLKAGDLIRKFGSAIWSNHERLRKVGEVVGQNLNRPIPVKVSRGVGADAQELELRLTPRQNWGGRGTLGCHIVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIT4</accession>
    <name>A0A0D2BIT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238691.1">
        <property type="nucleotide sequence ID" value="XM_016377121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIT4"/>
    <dbReference type="STRING" id="91928.A0A0D2BIT4"/>
    <dbReference type="GeneID" id="27329846"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02763"/>
    <dbReference type="HOGENOM" id="CLU_1219705_0_0_1"/>
    <dbReference type="OrthoDB" id="4148037at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="66"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="227" mass="25347" checksum="7ED8D10AC89B41B9" modified="2015-04-29" version="1">MLEESSVVDIGKVLLDCDQVAHPCGSFDAIPGSLAFRMEHSTTFRWRDELSYVLPPPEALDMLSDSYFNSVNWFMLAIDEPKFRARSTRVLANEYVSTADRNFIFLMSLVWGLGAHYLWTSPATSSNMPVPTSLIAEMMKVLDVAYLRITASPTLETVQIAILWGSFHLFNGLPYLGFTIIGSAVRCAQAIGLHRQQRTSSTEESCLVWWAVEIGDKFVPDHASSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIU5</accession>
    <name>A0A0D2BIU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_10579</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231495.1">
        <property type="nucleotide sequence ID" value="XM_016384893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIU5"/>
    <dbReference type="STRING" id="91928.A0A0D2BIU5"/>
    <dbReference type="GeneID" id="27337662"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10579"/>
    <dbReference type="HOGENOM" id="CLU_072128_0_0_1"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="73"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW11279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="258" mass="29443" checksum="6E437DDEA1ED18CD" modified="2015-04-29" version="1">MNFFKWTAPSPPEPVTVLEPLHPFYPVGVEIANFVANDKTVAQLLAVFAAGCAVILGTTWLFSGRLAPHLKTMDRVIVLWFCLTGSIHLFFEGYFAYNHTRMGGAQDIFGQLWKEYALSDSRYLTSDPFVLCMESITAIFWGPLSFLMIYLIITSHPLRYPVQAIVSLGQVYGDVLYYATSLFDHYYKNLTYYRPEAYYFWFYFVFMNFIWIVIPGSLLADSVITTARAFKALNRMSKTLQGNGVAKKPKQNGHVKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ19</accession>
    <name>A0A0D2BJ19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238776.1">
        <property type="nucleotide sequence ID" value="XM_016377206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ19"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ19"/>
    <dbReference type="GeneID" id="27329931"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02848"/>
    <dbReference type="HOGENOM" id="CLU_046574_1_0_1"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="51"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="423" mass="47932" checksum="0D7CBEA4C7A54489" modified="2015-04-29" version="1">MLSNLYQSSSNFHVIPLKSDLRKDTLIGAEIAFNYNADGGDDSRLSRRLIDVKDLTESDLSLLRQALFEHSVIIFRNQQGVDPNTLPLLAAIWDDQVQSHHSGEIAALTATNNILSKNNAARIPRAKEVTILGQGSFDGYEGIPTLRLRHVNHLEFHDQPLSQEELGQGYTRFYRFHCDAPLYEKLPGKVTILHALKVPKSPRQKIKFENGQELELDAGATAFVSGARAFQLLTPEEQEFALNTIVQYAPRPYEWIQNCKATSDGLSIVTTGLEKPLEELTPWDPEKVQAHPMVWKNPLFPDRPHLQILGMCVKSLITIDPKTKERKVIDDLAEVRKICHSFQKKSMAPSYIYAHTWRDGDLVAFHNQGVWHTITGQLGDDDERETTDATEIARREVNKRLMWQCTMASGVPPEPFNQMLKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ42</accession>
    <name>A0A0D2BJ42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Urease</fullName>
            <ecNumber evidence="2 9">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_10669</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="11">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231585.1">
        <property type="nucleotide sequence ID" value="XM_016384983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ42"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ42"/>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="GeneID" id="27337752"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10669"/>
    <dbReference type="HOGENOM" id="CLU_000980_0_0_1"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050112">
        <property type="entry name" value="Urease_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="14">
        <location>
            <begin position="400"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12 13">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="10">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW11369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="836" mass="89586" checksum="5A99492AAAD6875F" modified="2015-04-29" version="1">MQLVPKEIDKLLTAQLGSLAQRRLARGVKLNHGEACALIASVLQELVRDGNHTCADLMAIGKQLLGRRHVLPAVVATLHTVQIEGTFKTGTYLVTVDHPISSDDGDLEKALYGSFLPVPSKEAFPLADAGEYEDEKMPGAVIPVKEGRIVLSEGRKRIKLKVTSKGDRPIQIGSHYHFIETNPALDFDRARAYGYHLDIPAGTSVRFEPGDTKTVTLVEISGNKVIHGGNNLATGAVDLSRVDDIITKLQAAGFAHTPEPAGDMAYIDAASLTRADYIGMFGPTTGDLVRLGTTDLWVRVEKDLTSYGDECKFGGGKTLREGMGQASNRRDDEVLDTVITNALIIDWTGIYKADVGIKHGVIKGIGKAGNPDVMAGVHKDLIVGNGTDVIAGEGLILTAGGFDSHIHLICPQQAYEAIASGVTTFLGGGTGPSSATNATTCTPGKMHMKQMLQAVDSLPVNYGITGKGNDSSPVSLRESCEAGACGLKLHEDWGTTPAAIDTCLSVCDEYDVQCLIHTDTLNESGFVESSIGAFKDRTIHTYHTEGAGGGHAPDIIKVVEYENVLPSSTSPTRPYTRDTLDEHLDMLMVCHHLSKNIPEDVAFAESRIRAETIAAEDVLHDLGAISMMSSDSQAMGRCGEVIMRTWNTAHKNKQQRGFLPEDAGTGADNFRVKRYVSKYTVNPAVAQGMSHLIGSVEVGKVADLVLWRPANFGTKPSQVLKSGLIAQAMMGDPNASIPTVEPIWSRPMFAPLVPKTSITFVSQKSIDLGIVAGYGLAKRVEAVKGCRNVGKKDMKFNDVLPKMKVDPERYTVQADGVVCTAEPATEVGLGQSAYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJK6</accession>
    <name>A0A0D2BJK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_10784</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231700.1">
        <property type="nucleotide sequence ID" value="XM_016385098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJK6"/>
    <dbReference type="STRING" id="91928.A0A0D2BJK6"/>
    <dbReference type="GeneID" id="27337867"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10784"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="21"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="503" mass="53277" checksum="FE69597B1FE9A545" modified="2015-04-29" version="1">MALAAKLKSWSEELTPYFIYLLFVATLGPLLFGYHLAELNAPQEVITCTKKSLTSSESSSTSLPQCIPMDSTQLGLVSSIFTLGGFLGALASGSLAARYGRLLVMRVNTVLLVLGPLGETFAPNITVLALGRLVSGLGAGVSVVVVPIYISEIAPPKEKGFFGAFTQIATNVGIFTTQVLGYFLSHGQMWRVILAVAGVIGVGQFLGLLFAVDSPKWQADHADPQQAKSNLRRIRGHGADISEEVEGWRSANLNDANDEEQTLLSPDENSNNNNSTATTSPSSSNPSRTNVSILGVLLDPRHNRAILAVVVVMMAQQLCGINSIIMYGVSLLADLLASNSALLNIFVSVLNVVATTAFAPLADVLGRKACILASIAGMGASSVLLAVGIRSAIPVLSAVSVLLFVGSFAFGLGPVPFILSSELVGPEAVGATQSWALAANWISTFVVAQFFPMVNERLGKGVVYFVFAGLAGVFFVFVSWYVPETKGKKDADEVWGRTSRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK69</accession>
    <name>A0A0D2BK69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231885.1">
        <property type="nucleotide sequence ID" value="XM_016385283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK69"/>
    <dbReference type="STRING" id="91928.A0A0D2BK69"/>
    <dbReference type="GeneID" id="27338054"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10971"/>
    <dbReference type="HOGENOM" id="CLU_038717_0_0_1"/>
    <dbReference type="OrthoDB" id="72269at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="278" mass="29809" checksum="8A7A3A7E13937EDF" modified="2015-04-29" version="1">MTNLLPPFLGHSTSIYGVLFQSIGAGVIVPLYVTIYLFTSPLVTPGTPLTPSALAVDEGVLSALPVGVLLGYIVPSVAMSLPDPAMISQSAKVLAIVVWQLFPVWTNLITFVVEALLGPSTTRRPSEPETLKNQLPRLKTVYKLAMAVSVPVHIATWTLSLSTVLFPALFTPATVEAFHPLNAIVPPNPLAESKAPSVAQGAVWFLQYDYLITSFVYVFWAVVGRYGKLGGFGFTSLLDVIGRCAIMGPISTALHLLQERDEIVFAASETLTATKKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKH5</accession>
    <name>A0A0D2BKH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231995.1">
        <property type="nucleotide sequence ID" value="XM_016383372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKH5"/>
    <dbReference type="STRING" id="91928.A0A0D2BKH5"/>
    <dbReference type="GeneID" id="27336134"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09051"/>
    <dbReference type="HOGENOM" id="CLU_169286_3_0_1"/>
    <dbReference type="OrthoDB" id="532630at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="75" mass="8683" checksum="F0AD81418569593D" modified="2015-04-29" version="1">MTALDECHARGFLYKAIGGCNDIKREVNRCLSGERTKNSSKNRESALERRKRIEAIWEKMDEGDYSALEAFTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKY1</accession>
    <name>A0A0D2BKY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1760-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232110.1">
        <property type="nucleotide sequence ID" value="XM_016383487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKY1"/>
    <dbReference type="STRING" id="91928.A0A0D2BKY1"/>
    <dbReference type="GeneID" id="27336250"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09167"/>
    <dbReference type="HOGENOM" id="CLU_011932_0_0_1"/>
    <dbReference type="OrthoDB" id="5396786at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040347">
        <property type="entry name" value="YBP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020:SF1">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="83999" checksum="9BD4BC2FF4D3A707" modified="2015-04-29" version="1">MADNAPQEDPLVAALPPATDYMTYLTLLEYQLTPEKLPTLNRLLTEDDGKLAKEIGWDLLRLVLPMLDSAPAEANQCLEIIARRGNPREVVVRVAEELEKLGDDAEEDSPDPDVDEVDMATFSGEAPRVHLGSMKLDGMPETEQAPKNEPELVSGPAEKKNFAPVDKGLRLQALFNILGVVHPRIKTQYPSRFLATSLPPALGAYRHVPITIETTTAFLTMLENLSGKKRPPLPPRTGTVDDPTAGSEAAEQSKTVTATPASLPDPEAKGEEESRGNMTASVEEKAIIFRLLNAVNLEVLDEYLSFLASAEHPSMSWTARLRETFEPKRVVPGRPSETQHWKETPELQERDALLARFHKLAAELDLSTSQEVTKLVHDEDDDADGSEEAKEEPSEYPTSPAQIPFPRNGVIFLFAYETFSKPIDAPLILSTSDLTKLTAHAFPLSATPSIPSPALLDSLLSLLYRHAVPHSSPNPTPHPPPSPAKFILLLSTLTQVFTITPWPSLRDSAHYIASKLLHAYPDRDVRLQIITQTLRGDTLSTNWAETFEEDPDVQPGIDEGTGLTRSTSALQPHPIPLGPPQQSGNLKAVGVDWLKDEFAAHMTMTVQTSKTEAGSEAACVGGGGSGLDPSIFTSLDDHDHDRKIQSQTETGTLLDLLFPRRLPPLTYPEFTPETLTAFLRDIPFYISTLNLLCVMLPHVDGGALDFTIRAAAHVANLSGPAKNLLELLEHFATREDSADALEGSRADICALKDATARATKVLERTTEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLN9</accession>
    <name>A0A0D2BLN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239691.1">
        <property type="nucleotide sequence ID" value="XM_016374415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLN9"/>
    <dbReference type="STRING" id="91928.A0A0D2BLN9"/>
    <dbReference type="GeneID" id="27327130"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00047"/>
    <dbReference type="HOGENOM" id="CLU_029214_3_0_1"/>
    <dbReference type="OrthoDB" id="2431049at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.80:FF:000001">
        <property type="entry name" value="Chromosome segregation protein (Pcs1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="2">
        <location>
            <begin position="387"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="496" mass="54933" checksum="A0F173268F625541" modified="2015-04-29" version="1">MKGIAQLLDSDIEETAALADDRSDVSSEGEENATNSTQAKKRRKRQRVTMPAKKIKTSDQPSATTHSKKAPSKRKVPAQRKPIEDELDQPSDGDTQNSDAKQRAPEPKQKKSTGATQTKPKTKKLPRTTEDQLGTRKENAKSEPSAKDSDPKDEVEPPRPSKKTTGARKPSALKENVAPIIESLQETFDESEESELMPAEHRTRPQQVSRNPSRTRQESVYQRRPVSTAGTDNLRRELGDITRQLENSELRYRSLKEVGIDEAMGKMEALRREHNVTVQASNDVIASLKRSLAAQPRLDQEVQRLRTDLQSRVDEISGMQREITALNGSLSAATNEVKALQAKLAATRAPSVETMSSKASGSAVKGKSHGSVAMGNSDAAQAVQYAQMKEDLYSDLTGLIVRSVKKADSGDTFDCIQTGQNGTLHFKLFVPQEGPRGAHFEEPDILYTPLLDGNRDRDMIEIMPSYLTEVITFSRQNAAKFYGRVVDTLTKRRPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM08</accession>
    <name>A0A0D2BM08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Norsolorinic acid ketoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239836.1">
        <property type="nucleotide sequence ID" value="XM_016374560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM08"/>
    <dbReference type="GeneID" id="27327276"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00193"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="20364" checksum="E21908BE987A48F1" modified="2015-04-29" version="1">MATTTKTTYLITGGNRGIGKGLVAAYLSRPDTIVIAGVRNPTHPTSLSLQELPKEASSSLIVAKIDSLSETDAQDAVAELGSKHGVTSLDVVVANAGISAIWPPVAEARPSDMLEHYRVNVVGVTLLFQAVLPLLKASAKSPKFVTVGSIAGSIAAQENAPVPNAAYGPSKAGLNWITKKIHLEHPDIIAFPLSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM91</accession>
    <name>A0A0D2BM91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00598</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240239.1">
        <property type="nucleotide sequence ID" value="XM_016374963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM91"/>
    <dbReference type="STRING" id="91928.A0A0D2BM91"/>
    <dbReference type="GeneID" id="27327681"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00598"/>
    <dbReference type="HOGENOM" id="CLU_054059_1_0_1"/>
    <dbReference type="OrthoDB" id="252020at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12365">
        <property type="entry name" value="RRM_RNPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034201">
        <property type="entry name" value="RNPS1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="104"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="317" mass="34726" checksum="07A70271EF5AB5D9" modified="2015-04-29" version="1">MASPSPPRGRSPARSATPPSARQVPSGHYSRSPAGRRSPSPRSGSRSYSRSPPSRDGRNGHARGRSTSASSSRSRSPSRGDRRSYRNRSYTRSPSRESRRAQSSKIVVEKLTKNVTEAHLREIFGSYGRIESIDLPLNKQFMTNRGTAYILYDHPSGSEAAIAHMHEAQLDGMVISQGRRDQVHHLQATNLLPGDHLEHDTRVPHQEEEVSEEVEDARTTTVTCHEQHIPGRLHHLDAEGGHPRIRDRLREALRGAANRQVEAPHGEGEGVQATALGAVIVGAQAGREVVPGVDLDTEGGDEAEMPLWGGTQYPKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMI5</accession>
    <name>A0A0D2BMI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1765-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240016.1">
        <property type="nucleotide sequence ID" value="XM_016374740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMI5"/>
    <dbReference type="STRING" id="91928.A0A0D2BMI5"/>
    <dbReference type="GeneID" id="27327458"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00375"/>
    <dbReference type="HOGENOM" id="CLU_003877_1_1_1"/>
    <dbReference type="OrthoDB" id="296767at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988:SF1">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="951"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1108" mass="124936" checksum="ADD408AB4F914A0A" modified="2015-04-29" version="1">MSAGADGQIMPTVPVHAASPLHSSVHVLDRDPIHRPPSTELPRSASYTYLSTLETEPAVTTIKRTFSDNVLSLPPEVKTKMKDSVQSTNKVLFRRASKKAKKRITSGIFSFASDQEQGQRDDEVRGGRKTERDPIKAEQSRSLSRSVTGTIRTLARKSWAGSRPSSPAPKDGSAPRKKRSWSPSKIKDAATSKPASSRSPSKSPESDAANPVAAKPRRPPLSVIAAKNKSEISLRRLSRNSSSTSLASNDRSRSKISLANLPPLPRNLSSDRLASFQQDVTKRKDPLATVFRNIDSEFITFHAKPSVQKSKVLRTVLLPFLHKYARHPSIISLRAEDLDRRTVILNKWWTALLEMLHGTSNHLISLSDRPAFLESVSMIVSRPEWTVPGFNAVPGDASQPPSIPKSKSTNSLESEDSDFLSDTIKQNVRNMFIQNLLSQLRFVIEKLSWRAAPSSLVTFAGKTCAYAFFYCPGVADMLTRQWNLSAGILGRIFTQYDIHFGDKLALISNGFAANFPPPIRSLSVVSQGTFARYLQPRRQRPQGLEQLDWWHPTWVNRWCGRDTDLFFSFTKHFHILVSEFLSEELSPKERAGIPGLIPVCAQMLVVLEATLYRQANQPRYDDDGGEGSRFDRDHPDSLAPLPVIANADRSIAENRLVILLRDVLGDLDPETAMFRNLFTGSFEAVLKTATRKIPVYSTDPCFVICDFMEEVLPITFRYHQTYGDTPILDWPFWLRVFKQMMRSQSMLTKVRLMAFLYNKWTILISNEMWKRELVLEWLLDQEVFQENFCNWSPMVRHYFYRLLCWRVARVDGAVTTLDIIIFQTFKARLDKCWAHYQYLLMEADSRGLPQPSSEPCTPAPARLLLIVRLDNQPLLVPHRTTYERQQANLGLLNQPSPYQNHSSALNTIPTADVPPQINKKRWSLFRGISMFSQPGNDRPGEVTPPGSPDETSTNSNGTSTGSSNDIVCPTPVSRPITPPHQACSFRFELQHHRALPQLQIQNWTLTPPRLPQTAQNILRVRESSESNANSDSSSEDQKFRPKAKTVEPQKPTASELGNARYSGRALAEWSQVVSECRNFYIRRRQDGVPRDGLVEIPTLGVENFRSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMW4</accession>
    <name>A0A0D2BMW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bud emergence protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240116.1">
        <property type="nucleotide sequence ID" value="XM_016374840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMW4"/>
    <dbReference type="STRING" id="91928.A0A0D2BMW4"/>
    <dbReference type="GeneID" id="27327558"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00475"/>
    <dbReference type="HOGENOM" id="CLU_014957_1_0_1"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000184">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000250">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000041">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="156"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="320"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="530"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="439"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="66935" checksum="29B936E9FCBDC98F" modified="2015-04-29" version="1">MKAIRRSLKGDKESRHAPSLSITPKTIQALPPKKVIKALYDYAPQNGNGQELAFHKGDFFHVLSREDDTEWYEACNPLVPSARGLVPVAFFEVVGKQQRQSGNSLSSPGERAESHDSGFSEKGSTHSGHMRSESTATARPPTHTRGASMIGKAGGGAMVYGVVQYDFNAERPDELDAKAGEAIIVVAQSNPEWFVAKPIGRLGGPGLIPVSFVDIKDTATMASVADPLEAVRKAGVPKVEEWKKFAAEYKNNSISLGKFSSPEAQMSADMARMSLQNGGSQQSLASNTYVSYNGQVWVGAPHSYTQQSQGSGQRTSQQSQIPLAPVSASVPRYCFDNDMYWYIIECQMEDGRWWELSRYYADFYDFQIALLEMFPEEAGNKGKPRTLPFMPGPVAHVTDAISNGRRQNLDEYIKKIVAMPSHISKSMLVRNLFKPRPNQDFEIDPSALGEDYRLSGGSQQSMQQLSTVSTNQQSTGTGYGGLGMTSSSRSSQQRPPPNMTAGPPFLHSQASNLTQASTSSSMRAGNANGPMKVKVFFQDDIIAIRVPQDIAFGALKERLMERLKLNDDIVIHYKDELSNSMLELENDDNLDEALQRNPKLTLHVNYAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNH4</accession>
    <name>A0A0D2BNH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240296.1">
        <property type="nucleotide sequence ID" value="XM_016375020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNH4"/>
    <dbReference type="STRING" id="91928.A0A0D2BNH4"/>
    <dbReference type="GeneID" id="27327738"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00655"/>
    <dbReference type="HOGENOM" id="CLU_050231_0_0_1"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04370">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46364">
        <property type="entry name" value="OS08G0421900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="132"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="437" mass="49205" checksum="12F28B746BD8EBAE" modified="2015-04-29" version="1">MAPTESTSESYLHNLPLTPRESDNEDLTNLTPMAGRKRNASEMEDDGDKSTASKVAEGTSETIEAEISSDFTVECPARPRRTKSPIPEDVYYETAAPSLAPNLSVNFAVRPGDKWARFSRYRNAKFKDPLLLVYSAGQIVYVNRQDPLPPPLPADASEDEKLQYDKENLWAGLISEFRAESQEKVYVRVFWFYWPEELPMGRQPYHGKRELILSNHVGIIEAQCISSHADISQWDENDDSNKIILSERYWRQTLDVKKLAKDRDHALSKLRRFCICGGYDNPSMDMYQCRKVGCGLWNHEQCLIKAIEERAWAKFKKGTLTHEIQERDEGKGFAQKVGETVSNLAHRAFGKDGLGAEAMVIVKGNKKRKGVPTGKHVWAGKLQGAIHKTKTVDGSDAHYATVTQLVPTSGSAEFPSGFEPKTWQMKMSCLKCGEPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNY2</accession>
    <name>A0A0D2BNY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233040.1">
        <property type="nucleotide sequence ID" value="XM_016382337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNY2"/>
    <dbReference type="GeneID" id="27335094"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08011"/>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF2">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW12824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="70296" checksum="BFD078968865C9E2" modified="2015-04-29" version="1">MAPFLDITGQVTPPVTDGEVPAVYNLDAKNLPESLSHFTLVNGKLGVRDAAIKEDFSEHAIPLNTDFAYTPRKLRVITIGAGFSGLLVAHKFQHRFPELQDIIDHKIFEARADVGGTWLVNTYPGVQCDVPSHIYAFPFDPNPDWERFYASGAAIEEYIKHTVKKWNLDRDLHLNTRVIAAEWQETSGQWKVTVEHNGRQRDEFCEILISGQGVLVNPAWPKIPGLSDFKGHVTHSADWDHSFDYSNKRIAVIGNGSSGIQIVPQMQKLPGTTVKNFIRGPAWVYYRVPASKHLGRDTDDLNPAYTEEEKRRYQDPEQHRQYRKGIISRTNKAFRLFIKGERNDEVMRLATAQMSEKLNHDPVLCEQLIPKWELGCRRVTPGPGYLESFMEPNCSLTSSPITRITEKGVVTADGEEFECDVVVCATGFDVSHVPKFSMIGQNGVNLADKWAKEPESYLSVATDGFPNYFMMMGPNCLGGHGSLVESLNWTGDYFVKMIKKIATEDIKYVAPKASAVDAFVKYGDEIHKTLVWTGSCSSWYKRGRVNGRVTALFGGSAVLFHRLISEIRAEDYEIAYNSPNPFRFMGNGFTEWEMQEDSDLSWYVEIPDPLPEARTRTQAQAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPP1</accession>
    <name>A0A0D2BPP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241144.1">
        <property type="nucleotide sequence ID" value="XM_016375868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPP1"/>
    <dbReference type="STRING" id="91928.A0A0D2BPP1"/>
    <dbReference type="GeneID" id="27328590"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01507"/>
    <dbReference type="HOGENOM" id="CLU_071328_0_0_1"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239249" evidence="1">
        <location>
            <begin position="20"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="341" mass="35895" checksum="05B0C92BC9ED16B5" modified="2015-04-29" version="1">MYPLIVSIALSFFAKSAFAVPAFVTGTALPPQITQQAGGGLPNQPGTPKLSQNAINNFQVANFLENLESAFFQEGLMNFTRWGSGGTTNGVSNFNVVSHIAAQEEVHVASIVGLLTGTGAQDILPCEYNFPVTDETSFFALGNIITSVGIGALIGLQSALSTTDPGLEATVGSILPVESRHDAFFRITAGEIPNPTTFETPISGIWAYNLALDFVVGGSCKNLPQSITSLPVFPDLGIVGYGGPSFATPNAPGELVFRVGQPTMMPQGWNKDIPLYMAWVNQDNVPAYTPVTTDANGDLHADVQPNMFGMAFAALTNQNTATNIDDLTKATLAGPIPIPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPY2</accession>
    <name>A0A0D2BPY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233400.1">
        <property type="nucleotide sequence ID" value="XM_016382697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPY2"/>
    <dbReference type="STRING" id="91928.A0A0D2BPY2"/>
    <dbReference type="GeneID" id="27335454"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08371"/>
    <dbReference type="HOGENOM" id="CLU_059964_3_0_1"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="289" mass="30869" checksum="A8D6575BCF1A5665" modified="2015-04-29" version="1">MAKIMNNANTLRKALHTGSGLSFGAWQMLPGAYLSRVIARAGYDWVCIDCEHGNIADNEMHESVHALASINVSPIVRIPANEGWMVKRALDAGAHGIIVPLLTSVDDAKKLVQTAKFPPYGKRGFGSPFSMGSFDIQGNLSGFDYMTNANDNLLTIVQIETKEALDCVEEIAKVDGIDVLFIGPWDLGNNIGHPVTGDFSPELQKAIARILKAAQDAGKKSGIYCPSGEFARRYADMGFQMISVVNDMTALPTFMADSLSKAKGTYGHAAAQAVKGAAYGAAKLATGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRD4</accession>
    <name>A0A0D2BRD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_06604</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234040.1">
        <property type="nucleotide sequence ID" value="XM_016380938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRD4"/>
    <dbReference type="STRING" id="91928.A0A0D2BRD4"/>
    <dbReference type="GeneID" id="27333687"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06604"/>
    <dbReference type="HOGENOM" id="CLU_009281_2_2_1"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000085">
        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF75">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="12">
        <location>
            <begin position="273"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW13824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="512" mass="55573" checksum="C2C01C6697F12A39" modified="2015-04-29" version="1">MGSVHEVFVGSIDQGTTSSRFLIFNKQGEPVASHQLEFKQIYPQPGWHEHDPLEIVAGVEECIDGAVKQFENQGHNINSIKAVGITNQRETTVVWDKETGEPLYNAIVWTDTRTQGLVRKLKQRLGADRLTDICGLPLSTYPSVGKLLWLLENEPKVQKAYERGTLAFGTIDAWLVFKLNGGTKRNIFVSDPSNASRTMFMNIKTLKYDESLIDFFRIDRTKVHFPKIVHSSDPSAYGSLASTVLKGVPITGCLGDQSAALVGQKGFTPGLGKNTYGTGSFILYNVGEKPVISTHGLLTTVAFDFGGNSKPMYALEGSIAVAGSSVKFLVDNFGFIENSSKISQLAETVDDNGGVTFVTAFSGLFAPYWIDDARGTIFGITAFTNRGHIARATLEATCFQTKAILVAMEKDSGHTLTELAVDGGMCNSDLTMQTQSDLISIPVKRPAMRETTALGAAIAAGLAVGVWDSIDELKAVNTEGVTTFKPAISKEESASRFARWEKAVEMSKGWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BTW6</accession>
    <name>A0A0D2BTW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_07493</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234925.1">
        <property type="nucleotide sequence ID" value="XM_016381823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BTW6"/>
    <dbReference type="STRING" id="91928.A0A0D2BTW6"/>
    <dbReference type="GeneID" id="27334576"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07493"/>
    <dbReference type="HOGENOM" id="CLU_013253_9_3_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="59"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="495" mass="50481" checksum="5CC07653AB83B5CF" modified="2015-04-29" version="1">MYVAGALAGLTFVTSCLASPGYLKLDFQKRRQHEAWLAQRAVDGTVDAILTQATTKLEYLVNITVGTPPQSLAVTLDTGSSDLWVPASSSTLCKKGKCDEGSFTRTRSSTYKLVQQDGFNITYAGPGDSDAGDWAMDTVTVGGSPSIKNQQFGLATSLVDSHGVMGIGYDTNEAYNPENVYPTVLDNLKSNGIIDRKAYSLYLNDLQANTGAIIFGGIDTSKYTGDLIALPFQQGPTGGVTEFYVTLTGVSFTDHAGSTTQLTPQGYAQAVLLDSGTSATLLTDEVFSAIVNGFGAVGIGDDDYVVPCSYATADGSINYYFGGEGGINISVPISQLVGGLDIPPQDFGDKSGGCDFGFGPPIDGVSILGDTFLRSAYAVFDLDNNLAALAQAVENKTDVSSIAAIPSGTSIPGASVTATATGTQLSGAATTALPAVPTASAQGSTILAGTPTFNLGVSVTRGSSAATSSSSGSANAATPGVVLLGLGLAAGILGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BUR1</accession>
    <name>A0A0D2BUR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07751</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235180.1">
        <property type="nucleotide sequence ID" value="XM_016382078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BUR1"/>
    <dbReference type="GeneID" id="27334834"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07751"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000295">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="531" mass="58629" checksum="DF1F49BC34958226" modified="2015-04-29" version="1">MVPTDDKRNHMAHDEDIETGQPALVLAEQKHGDRALEIVGTDRVELTEEDNKRIRRKTDKRILTILVWVYFLQILDKSVLGYGALFGLQKDCNLTGNQYSLVGSIAPIAQLAWQPFSSVLIVKVPHRILMPTLCLGWGIAQASMAACHDFSSLMAARFFLGLFEGGCLPLFSVITSQWYRRAEQPLRVAAWYGTNGLATIAASALSYGLGKIKSDVLKEWQIIFLFVGLVTIVSAPVVWWYLDDDIPSARFLTEHEKAQAIERLRANNTGTGSREYKWSHILELAIEPKTYLWIGMALLLNVGASVTNTFGPLILSGVGFDKYKTTLLNIPFGAMQFLVILLASYAAQKAKLKSVVLDALMLPVVAGLAVLYCLPRDHGATAGLLVAYYLLAFLFGGNPLIVSWIVGNTGGSTKKSVIMSLYNAGSSSGNIIGPLLFNKKEAPAYHPGLRSTLAIFVTLFAVVIMQLVNLMFLNKLQSRTRVKNGKPAVIKDHSMEDTYVAVEETEGGQRLGDKAFLDLTDRKNDEFTYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BW18</accession>
    <name>A0A0D2BW18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NFACT RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235665.1">
        <property type="nucleotide sequence ID" value="XM_016379838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BW18"/>
    <dbReference type="STRING" id="91928.A0A0D2BW18"/>
    <dbReference type="GeneID" id="27332578"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05495"/>
    <dbReference type="HOGENOM" id="CLU_076656_0_0_1"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="3">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="197" mass="23063" checksum="27FE6B535C10420E" modified="2015-04-29" version="1">MSQNITTDGDVLFASDAINGRYQFHVDNLSSAHVYLRLKPGDSWTSIPQALLEDCAQLTKANSIEGNKKDNVTVIYTPWANLRKDASMATGQVSFHDPKMVKKVHVAVRQNPIVNRLNKTRVEKFPDLRAEKEADQREKRKVERIAREQQKARDREERKKREELRWQKDHAYDDIMSEEHMVSNQDQDARFYEEDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWU1</accession>
    <name>A0A0D2BWU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_05824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235990.1">
        <property type="nucleotide sequence ID" value="XM_016380163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWU1"/>
    <dbReference type="GeneID" id="27332907"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05824"/>
    <dbReference type="HOGENOM" id="CLU_014819_4_1_1"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112408" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW15774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="522" mass="56681" checksum="A090624BB6716880" modified="2015-04-29" version="1">MRVSSFLVAGFTTLVYHCSAVLADLSYTCENVTLYRGVAETAPFYIVNSTTIAANRTAQLPEYCYLQAVIGGRINAWAKLPAAPDYNGRFVQWGCGGACGINPFDGEQDNRTTALVEGYALTTTDMGNSGDGSFFPFFNDLQCKIDWGYEATHLTAVFSRLLVEAYYGSAPRYAYFIGSSTGGRQGLVEAQRFPGDFDGIVSVAPAYNETGITTYQMSWNTAACIYNTANTSDPVLTTEALSLISEAILDACDGEDGMVDGIIANPRGCSFNLTALACSSGPPNSSQCLSPAAVAAARSMFVGPRNSEGIYLTLEGLLPGSEAAWTGSLCPTGGQTAGFYTFATQYLSYYVFNPDVVGGLEAYDFNMDTPLRETAYTESFEYGGISDLSRFKQLGGRLIMAQGLRDPAVPPWFATDYYQRVVTAMGGYERTVDFFRYYEMPGVNHVSGGPGADSWDQIGLISAWVERDEAPETITAYHLDDGAVNFTRPLYPWPFLPYYNGNTSEFYAFNASGSTLRGYTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BY78</accession>
    <name>A0A0D2BY78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236485.1">
        <property type="nucleotide sequence ID" value="XM_016380658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BY78"/>
    <dbReference type="STRING" id="91928.A0A0D2BY78"/>
    <dbReference type="GeneID" id="27333403"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06320"/>
    <dbReference type="HOGENOM" id="CLU_012201_3_0_1"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01941">
        <property type="entry name" value="YeiC_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="7">
        <location>
            <begin position="422"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="785" mass="83563" checksum="C737A1F9C57BC5E2" modified="2015-04-29" version="1">MALLHRSWQARGAVRRCCGLPVSHHRSFSGREKLLRVSEEVQDALATGKPVVALETTIYTHGFPYPENVALSSHLESLVRVNGGVPATIGILNGVARVGMQAEELIELVSSAGSENTWKISRRDLGFIGGLGLRGQKLNGGTTIAGTMVLAHLAGIKIFATGGLGGVHRGGENSMDISADLTELGRTPVAVISSGSKSFLDIPRTLEYLETQGVGVGTFADGRTGKVDFPAFFCRDSGVRSPQTILDEADAAAIIYAQFQLPVHSGLLFANPVPEHSAMEKEQIDSIISQAVTEAEEKGIGGNANTPYILKRIRELSQGASVKANEALIDANVVRGTKIAVELAKLERRDGAAPQRDNAISTHSAAASRKSTAKHDSANIDSKTSHQNESIDVLVAGSLASDTICDHQPFQGIHSSTSPTLHTSNPSHISQSAGGVGRNVAMSAHFAGAKVALASVVADDLAGSSLLAHIKESGLTTTNIRTLSTADGARTAQYVAVNDTSKDLVLAMADMDILARPEMESLDYWTTILNRNKPKWVVTDANWSPEILSSIFQAAKAQKAMIAFEPVSTAKAARLFSKANNIMVQAGVVPNHVISLASPNSMELKAIYDAATDAMMFESEQWWKVIDGFGLSGTASRDRLVSVAGAELVNDGIPQQCIQLLPFIPNLVTKLGRHGCLLVSLLRRTDERLTRPEYAPYILSRNMSEDSEIGGVFMRLIPPAEKVRQEEIVSVNGIGDTMLGVIVAGLGKGYTLEEVIPVAQEAAVLTLKSAEAVSPEVTSIQARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZP4</accession>
    <name>A0A0D2BZP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237040.1">
        <property type="nucleotide sequence ID" value="XM_016378363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZP4"/>
    <dbReference type="STRING" id="91928.A0A0D2BZP4"/>
    <dbReference type="GeneID" id="27331097"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04014"/>
    <dbReference type="HOGENOM" id="CLU_015497_0_0_1"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="755" mass="81256" checksum="855FD5DC457C0AAA" modified="2015-04-29" version="1">MPPFKDEHVLIIAPGSYITSAQLGLPESFTPPRYRFPSRMFPGANPGEWEPTKIRSKITSKRKEAPQEPQATQNGETKVESTAEPAQGLPPTIEQPVASSIEVDQIQTKSDEISSQTATEKAELQEGESDAVLPVESSKPEQTSEAVPLADVEMAEAPAEAKDPVPEAPKPDTDMADAPTQEEAKQETASAQEAIEAAKSEPDTEMKEAAQEVEEEVIEHEDDPYATEGAVYPIVEGRIENWPCFFALLSHVYNMVSPPFHSPVLFVSQPCWSARDNEMITQFVFENWKIPAFCLMDAALTGIYAYGIPTGLVVDIGYEKCDVTAVTEFQVNDIGRGAGLRGCGGQTMTKRLQQVLEKQGFTEDMAEQLKKSPICEILPAGVAYPTVAHNGFAPNPASAASTGALDSGLNAKDEEGLRPGQAPRGPGTGTVVGEEAGNGDDDENEGVLDVAAIVARDNAAELLAKREKEKAEKAAAAKKGAAAEAPKQIRLRNSERERATFTYVEYLPPDESDDAERVSRRKKREVEVGVERFMAATPLAGNAEGLIDTIAEAIHHAALSVPDIAMRSALWDNLIVVGNGSRVRGFTSSLVSILNSRYVLSPSTATIFTSELPSNFTTPVATPGTNTPIPGQVGQQLHHPGGGVNPLLVAATKNMMQPNQHLQVQGQLPPGQDQGMGYHHRGFSQSPTSVKTVKMPDYFPEWKDPHVSGMEEAAFLGAQVAAKVVFIVDQGNSKGFLTRTEYNDLGPAGIHECTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0C1</accession>
    <name>A0A0D2C0C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237245.1">
        <property type="nucleotide sequence ID" value="XM_016378568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0C1"/>
    <dbReference type="GeneID" id="27331303"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04220"/>
    <dbReference type="HOGENOM" id="CLU_026304_1_0_1"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="25"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="502" mass="57975" checksum="9D6CC4E3755E2698" modified="2015-04-29" version="1">MANHQRPPGPDNLFPPQDVCNELVDLYFDIIHDKDHMLFHRPTFVSAHRKGMVDMTHIAAMMALAARFSSNPWFQDSNRWTRGSVWANYSKHLFDNRKDKVSLAAIQSCVLLSTIAFCDVDMEMESLYGAQAIRMVQLKALPDQRGESLVQRETEIRVWWTVWMLDRWASAEARIPKQLVADSRFPVPMTEQLFEQMSADWCDLNQTSPLERLQLEHRGFWAHLIPVTELIEPINELHEMTVQGRLTDLELYDHVESIASKLTSWRLHLPESLEFTPENLLRYANTGHGRILAALHSGFHHQSQLLYYQFLQPSIATNAESSTRVLEYASRCRQHATDITNLFWLARQTPRCKAMWPMVGHLLAVSSSVHLHSLLFSEDAGRVSSVKHMLKQNFEMMMELRQYWPSIDLSMSRLRSFHQACQRSMNTSFIMDHWMLQFLQQYTKPVQGRDIFHLYSGSSEPIQTSPAWMSSVGVEQGYIVDDSIAHSQVGLEVGTTILQTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6T1</accession>
    <name>A0A0D2C6T1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DOD-type homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239505.1">
        <property type="nucleotide sequence ID" value="XM_016377935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6T1"/>
    <dbReference type="STRING" id="91928.A0A0D2C6T1"/>
    <dbReference type="GeneID" id="27330666"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03583"/>
    <dbReference type="HOGENOM" id="CLU_007931_0_0_1"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="852"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="907" mass="100925" checksum="ADC80304F080B9A8" modified="2015-04-29" version="1">MRRFFAEVLLGTSTTHRNPLYLTRFAALLCALAIISSNSRTTVNAKQTIRQPAEAPTDFSPEEGQKQNYWANGGNNVVHEVWSILRDFEPTWKDSVGPAQPTSFLENVWYYIRLVFRTLFMNAPTRHDDETPQVKGDLRKAVETLKTAALFDDPDAIFILAEMNFYGNFSHPRNTPEALRWYNQLASLNGNNTAQYMVGLIYGTGLGGVPRDQAKALLYHTFAAGQGNINSEMTLAYRYHAGVGCPRDCNKAVSYYKRVADKAIAFWAGGPPGGRSLTRNAYRWVEADGGIYGEGASVSSSGPNAPRDGVITTHIDYVLDYLDTKERQGDFTAMLGIGKHYYEAPRGYKKNFRKAHRQFMKVARAYWGKDGKVNPKAPKDIDRVAAKAAAYLGRMFLRGEGVDQNFDKAAMWFKRAIANGDSFAQYHMGLMYRDGLGVPKDGLRAGTYLKAAAEQSLPIAQSALGVLFLDQGDIETASRYFELAAGAGVMEAFYYLAELTNQGIGRERNCGLASVYYKIVAERAEALHSSFLEANSAYERGDWERALVATIKAAEAGYENAQANVAYLLDRKTSVIDIPGLSKLLSGKPDIRPGRSKLLDDQYLALALFTRSAKQSNVDSLIKMGDYYLTLRPSLQVLSGLLPNETKENELKSNLERATTCYTTAAESHHSAQALWNLGWMHENGIGSVTQDFHMAKRYYDLALEMNKEAYLPVTLALAKLRLRSWWNGVSGGKINSIREDEDEDRKRPKSWGEWVNRFLDAAEEMDAQEAAAMMRERDGDDDMLGYPEPGMPGGDSDYAGREGQRHGEDVYGADEWEEIDDGLVESLIIIALAGTLAMLVYARQARQRGLEQERREAQERARAQAPLQPQPQVPTQPQAQDQQDNGMFPGPGDPEFNNWVAGGIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C829</accession>
    <name>A0A0D2C829_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Choline transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239950.1">
        <property type="nucleotide sequence ID" value="XM_016374674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C829"/>
    <dbReference type="GeneID" id="27327391"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00308"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_4_1"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF11">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="58454" checksum="C21D641FDFD8E8F5" modified="2015-04-29" version="1">MGSSPTTTEPEAIVAFNSENLSADELELRAQGHIGELPRQFGILSTLSLAFTITNSWIAYSAVFVIPLIAGGATCVVWSLVIGFVVCSIITLGLAELASAYPTSGGQYHFSFMVTPPRYRAAVSYTIGWVSVFSWWMLACGSAIFCAQAVAAMAAVYHPNFAATQWQIYLIYVALTILSTALITLFPKQLPRAEIACFWLSIIGFIVSTITVLARSDHKQTGRTVFADWKNNSGWIDGVAFFIGVGQGMFAFIALDAATHVSEEMPNPRRNVPRAMGLTMVIGMITGFVWTVAFLFSATDLDEVMNSPAPYLTVFFQAIHNDSAALFFTVWLFLAYVSATISCYATSGRLVWAFSRDNGLPYSDFFSKVHPTLKVPVNATVLTCIFAIFYGLIYIGSTTAFNSFLSISILGLNATYTVPQAIVAFCGRDKILPPRPFALGKWTGLFCNIFSSLWVAMYMVWFCFPTFLPVEAQSMNYLSVIAVGALFFIGLSWFLGKRKTFTGPKVVVEGLHLSTSHNAQTFEAVEGSEGGLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCE4</accession>
    <name>A0A0D2CCE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241385.1">
        <property type="nucleotide sequence ID" value="XM_016376109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCE4"/>
    <dbReference type="STRING" id="91928.A0A0D2CCE4"/>
    <dbReference type="GeneID" id="27328832"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01749"/>
    <dbReference type="HOGENOM" id="CLU_024328_0_0_1"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="274"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="6">
        <location>
            <begin position="439"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="686" mass="74725" checksum="2A62904E185DA96F" modified="2015-04-29" version="1">MASEFIGYTILVTLQSWCSPPNAQIQGVVADVRNQKLFLQNVLCLWNGQHLPTHVIDSSTIADLEVAPTQQSIAEEKGQHAPVPQSQPTQNASSSNASQSQQHAAAFTDPAIISYAKAPTKEARRPSIQQGPVSPIMIADGVISNHPARLQTGVAQRGSSVSSIATAVPKKGADKNTPASATLTEPFDALRLGNNVGASKAANTVNTVPQTTSQTGPGIIDMKDVNNGPLKKQKKAAKGKGWRQTPLIEEIPRQNKKKAQRGRRQAEDVNGWATEDATDIQDMPDFDFEENLSKFDKRRVFDDIRQADTTAEADRLVSFNRKARPGTNGGRNLHWTENVLETPNVKASDRWQSEAGETENEFVEDHYSSGKGSKRAGSRRPLQSRKGSVLPAHMDRTESPRPLARIQTSSPMNGSVSGIRASFKLPNNKPCHCLSPLQMLEIEQLCTSELGLTEDMVSENAGRSIAMAILKLPEAKNVAFLVGNHKSGARAIAAARHLRNRRLRVTIVILGGEREELLLEVMRKQLGIYKKGQGYVERWDEYQAKVSQGGMVPDIVVDVLLGVHATFEELRTDDQATVLEMIRWANRTSKILSVDVPSGLSATTGLLTEVDGQPLVMASKHIVSLGAPKTGLLHAMAMEAIEVTWQVWVADIGISAAAWQKHGSRRKHGVDFGTEWVIPVKFALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CDE9</accession>
    <name>A0A0D2CDE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241755.1">
        <property type="nucleotide sequence ID" value="XM_016376479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CDE9"/>
    <dbReference type="STRING" id="91928.A0A0D2CDE9"/>
    <dbReference type="GeneID" id="27329202"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02119"/>
    <dbReference type="HOGENOM" id="CLU_077728_0_1_1"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="217" mass="24498" checksum="A7BDAD6BB3CA4815" modified="2015-04-29" version="1">MSTTTTNLSPGIHLIGATTPEISTIVSSVVHLHATCILNDYTLATFLPPLSYDLMTSWWRQRFDEVTTGARHIVIQVSEVSERSSMDLAAPWASEGRGWPLLENGLEVSGVVTLSTPFSQTGPFRAVVQKLFVSPLHRQRGIAKRMLVKLEDVALAHDRWNLMLDTSVGSEADKVYPRLGYERLGIVREYGISPKDGRPVDEVWYWKDLRKHRIQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y5U8</accession>
    <name>A0A0D1Y5U8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NCS1 nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230502.1">
        <property type="nucleotide sequence ID" value="XM_016385558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y5U8"/>
    <dbReference type="GeneID" id="27338331"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11248"/>
    <dbReference type="HOGENOM" id="CLU_021555_2_0_1"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="63886" checksum="66AAA431E84DD2A0" modified="2015-04-29" version="1">MTLTNKFQERVRRNVQDFKHAFTSREAFVKYVETKPSAAANGTTTETVRNQWTNEDLDISPPGHRTWGWYDYAAFWFNYGFSPGMWYLGAALLANGLTPGQALGCLFLGFVFGSVGIVIHSRAAATYHFGFPVESRLVWGLWGSYFPVIIRALCALIWGGVTIATGGYFTSVLLRCIFGNGYWNMPSHIPESSHITVQQLIGIIVYWFMTCWTLNVPLPKLRRAYEIQMLVTPPVIIGLFIYCMLTGRGHAHQALYDVAPKHGAALSWALLAAVNSGLAKTTTLMVNQPDIARYARNRVAPVWSQLIMFPAASTACAAMGIYATQSIFNAWGNIDWNPWDLNHDMLDHDFSHGRRAGLAIINLVFIFGNTLIELGANVIPFGADFMSLFPRWLNIKRGMWMCYILGVCICPWQILATATGFLKFLNGYSIFLGSFLGMALTDYLVVRKGNVFVGDLYQPRGRYWYLHGVSWRAFATWIISISFMLPGFAQTFGAHIGASGNGWTHLYAFSWFYTCTISSVVYFALSFVGNFAQEERAMPFESLARTNDGVEELQAVEVVSEVHLPVEQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y712</accession>
    <name>A0A0D1Y712_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230897.1">
        <property type="nucleotide sequence ID" value="XM_016385953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y712"/>
    <dbReference type="STRING" id="91928.A0A0D1Y712"/>
    <dbReference type="GeneID" id="27338728"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11645"/>
    <dbReference type="HOGENOM" id="CLU_082760_2_0_1"/>
    <dbReference type="OrthoDB" id="9998495at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="22552" checksum="E6170B4F8C1F977E" modified="2015-04-29" version="1">MRLPYAPSTPPAGSPASVSDIYARIAARRKPRPLIPLDLTLLHSPPVANGYNAFVGALRTETIVPQSLLELAISRVAILTTAVYEWNIHAALALKAGLAPGALEVARSAPKGGVVEALTQSPAHDGTTTLSDKETAVLRYTDEATVDVRVQDATFETLKTLFNDREILELVTVVAGYNAVSRILVPLDVGENNDKKMKTVEELVAEGSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7C0</accession>
    <name>A0A0D1Y7C0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_10110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231027.1">
        <property type="nucleotide sequence ID" value="XM_016384425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7C0"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7C0"/>
    <dbReference type="GeneID" id="27337193"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10110"/>
    <dbReference type="HOGENOM" id="CLU_008699_2_0_1"/>
    <dbReference type="OrthoDB" id="3942062at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="639"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="705" mass="76689" checksum="1CD899EC0FB65494" modified="2015-04-29" version="1">MAEDEVVDETSQISATDSSDDDSEEEQIETLVAGRERRRTAGNRYDRDMVLEEAGDGEDADEVALLFADNEQEEDDEFNSGDDDEDADMSSSDDDDQGPNATVDDMEGEKELQKQAKAERARKRKADLALTSVAGLRKKLKTDPTRPAAITAPAKPSKKKERVTWVHDPDSGRSSLRKQTIAHRAETIARLKESEAQSKKLKALKEQRDRERAKDAPKELTQADRLAEAARIERQNAKSLNRWEALEKKRQEEQAAKLAALKNRKLEGPVITWWSAKATWVGPKLSKIGTKDAGEIFEAGTEPKKRGRKSKAFLEQQAAEKAAQYAVPSTTATSSEPSATSQPKPDVPETAPTEGLPTTPSHPDAATPMELDSNQPPEHPSKPDQSVASETALPTQTPSETPASPMATTSKPSPAPGGDIENPHEAMEEMASKQDGAPPAVEEDSVLNGIQEYADMPTESNASGSRHGSPDPKTAAEPEKTVQISDPEQVKAQTRPEQEKKVSAETASTDTEFTEIKTAQEPSLETEAKQTSEPPDISVSNPVPNSPVGGAPVTNIQSDPPQASPQVDPQKTVVKVEGSTEAPLAAAAPQPEPTVEYSTRNIVILETFDELSDDGRRDYALFYNKTVKKVDKRVKHVQELCPITALPVRYRDPGTGIGYANVVGYQKLQDLKQHRYIWSSMLGCYVGREGGPVARGVPEGFADKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y801</accession>
    <name>A0A0D1Y801_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-40S ribosomal protein S27a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_10350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231267.1">
        <property type="nucleotide sequence ID" value="XM_016384665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y801"/>
    <dbReference type="STRING" id="91928.A0A0D1Y801"/>
    <dbReference type="GeneID" id="27337433"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10350"/>
    <dbReference type="HOGENOM" id="CLU_010412_2_0_1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="154" mass="17773" checksum="80256B44F0895637" modified="2015-04-29" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKVYTTPKKIKHKRKKTKLAVLKYYKVDGDGKIERLRRECPQKECGAGVFMAAMHNRQYCGRCHLTYVFDETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8T3</accession>
    <name>A0A0D1Y8T3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231612.1">
        <property type="nucleotide sequence ID" value="XM_016385010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y8T3"/>
    <dbReference type="STRING" id="91928.A0A0D1Y8T3"/>
    <dbReference type="GeneID" id="27337779"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10696"/>
    <dbReference type="HOGENOM" id="CLU_074237_5_1_1"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="6">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="193" mass="20909" checksum="A455EEC0E0879E65" modified="2015-04-29" version="1">MLYFVVRGLNLTTTTTTTTTAQVHLIRRLRKLTGTNAFSHLRATGGEVGSSATLAPKIGPLGLSPKKVGEDIAKATGDWKGLRVTIKLTIQNRQAAVSVVPSASSLVIRALKEPPRDRKKEKNIKHSKSIPLEEIFDIARTMRGANKSLARELKGTVLEILGTAFSVGCQVDGRSPKEISDEIKEGNIEVPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YBK5</accession>
    <name>A0A0D1YBK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_09598</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232537.1">
        <property type="nucleotide sequence ID" value="XM_016383914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YBK5"/>
    <dbReference type="STRING" id="91928.A0A0D1YBK5"/>
    <dbReference type="GeneID" id="27336681"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09598"/>
    <dbReference type="HOGENOM" id="CLU_512915_0_0_1"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW12321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="60087" checksum="8AB8380CCB355C55" modified="2015-04-29" version="1">MSGFDSLSHADKPDQQRLQTQPLHLIGSEYPTEGYSREGLKPEPDFLDASLMKALNQHAMDGMCRHRKKCDNVRPVCSQCRKAGAECAQSKSQTSNDSIIVPRRYLDSLEEKVSELEKYGIGGIQNQFLKSLGSSPPLMTGVPRPDSPQHSLCFTINTPGLGQNGRPGFGKPIQCEECISGAFPTQFPSDLNMTLLEDVSRPAKTSTIQHTTALPGPYCISDYWHLELYANVYLAHIHKIYPFLDEDSARRWIMRICQGCLPIVGESIVLLRRYRSRRGTREEPQGTVSLSLPSITTEVEDQNPQVKRDTIMCCYNLNEIISFAWDPPQSAKLSSMDDNVFISTGNVGPQSLDVPSPLEHLFQLRRLQAKIRFFHESTRKLCFDRPFKAKWRDDLKADSDEWKQNTMSTLADQELLLAVYRPNCIHKVYSYTMCLLFQDISAFAGVDSFLTMLVAAAPACRKFKLMREKEGVLWLFNWTAVSTEASLIFVVALTDDFCARFSTNFVRGYHFFTVFGHLQTINALSISHHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YBN3</accession>
    <name>A0A0D1YBN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232572.1">
        <property type="nucleotide sequence ID" value="XM_016383949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YBN3"/>
    <dbReference type="STRING" id="91928.A0A0D1YBN3"/>
    <dbReference type="GeneID" id="27336716"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09633"/>
    <dbReference type="HOGENOM" id="CLU_044368_2_0_1"/>
    <dbReference type="OrthoDB" id="4117996at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37418" checksum="1A79CC7FA4F38AB3" modified="2015-04-29" version="1">MIPDGGLTIQDPEFASLGIEPLTWDDSSIDFSFLTSPRNDKTFQYPNPASSPSWLFRQLTREGDGSSEIQRHPMSPNLSIPSAPSFSVRSIVHRPRRKAATQRTASLILHILKSYPLMMMRHGSLPPFIHSGIVSSSADSDDMKALNNCVCLVHMMSAGVPGSRELFWKNVLGPNSTLKATSKHLNRIRKSAPYTYDLEQSWKDWVFEESARRICVVYQVINMLVYFEPAALCELDGDLLIAPLPARKQLWEAGDMLAWKAESEREPGIDIAFGLTTKGDLIRSGQDMTCSINETAVVHKSRYISTLSHSTANWEEWCSGMDGLGGLIMLAASLVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YC23</accession>
    <name>A0A0D1YC23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232687.1">
        <property type="nucleotide sequence ID" value="XM_016384064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YC23"/>
    <dbReference type="STRING" id="91928.A0A0D1YC23"/>
    <dbReference type="GeneID" id="27336831"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09748"/>
    <dbReference type="HOGENOM" id="CLU_060131_6_5_1"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="202" mass="22755" checksum="E7F5E33D9FC18228" modified="2015-04-29" version="1">MALAQRDAQESDIPTLCDIFFAAFTNDLVMSQTFPDVPDVRAFWESILKKGLEDPKCHTRCIVDTTLSGSPVVAYSRWIACNKDEVPPEGPLYPTGGNVEVCEAFFPQLRDKKLEIMKGREYWYLGLLCCRPSHQGQGAGRMLMQYGIDLADKERKEVYVEASPPGAPVYRKFGFKEVDRVVMFDGQFTELLMLRDAQKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCF1</accession>
    <name>A0A0D1YCF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232802.1">
        <property type="nucleotide sequence ID" value="XM_016384179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCF1"/>
    <dbReference type="STRING" id="91928.A0A0D1YCF1"/>
    <dbReference type="GeneID" id="27336947"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09864"/>
    <dbReference type="HOGENOM" id="CLU_022728_1_1_1"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="634" mass="67692" checksum="F55CD23AC30124D5" modified="2015-04-29" version="1">MRDHESVLTRILLLVVILLTSLIAIAVLVIKDRRSTGTFYGFVTSHRDTIGLLIQVVSAVLGAGQIFAITSLINLSARVRMQTGCPVAFQQLKFLVAITSGASRALRGSLPVEWLTVALIITLTLKLPAALWAGALTPILTDVTSMEGRIPVPTYPETALSAWQGSFRRLQNGTVSMSLNCSWVVTGDKMLDGAAALVSTCPAVDLVSAILGSLARAAAGTPSAPKPHSRIDSSGWTNLGRSFGVGSSPGIVPIQGLSAHKAPMLSLDYFEYGYRTNVSCARNEASNYTISEAAYLDDLGVTSHLVGGTLPNSVSGQVEQYALSSSTHDSNFLAWSALSNYGENILAVAGTGLYTAFDKMQCKVRFDPARFAVNVNVTNSIITVKPAADDQAVQNIEPTGEFTKSIFYALEQISRISGSTVVSTLGTALEHNIRVIKARDPGLSDEASAALSLEYGVGMLLEGLLVANAQSQLYILGNSATVPLSVRFGAVKIGSEKYIYCVLATNLAMLLTIIVEVVRTRFWKGLTTFDFTDIESIARSASVGGHAIAKQYQADRDPESSGRIFVSLRRHGNQWSLIPATGGCSSQGDWELEGHKPDAYCHAAESIVGHHGDGHGSWQPYHWDGAVYRPSPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YGJ1</accession>
    <name>A0A0D1YGJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234327.1">
        <property type="nucleotide sequence ID" value="XM_016381225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YGJ1"/>
    <dbReference type="STRING" id="91928.A0A0D1YGJ1"/>
    <dbReference type="GeneID" id="27333975"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06892"/>
    <dbReference type="HOGENOM" id="CLU_000288_31_3_1"/>
    <dbReference type="OrthoDB" id="4119972at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="284" mass="32626" checksum="1A905D018F47476D" modified="2015-04-29" version="1">MSNNLSGFSVGIKLSGSEAAKVYHSKTDTRYFERERDVYERLGQHPYIARLLRIQGQTIYLERGTCLRQVLRTQDLPIEKKREWIAELACGLEYIHSRNVIHADVNATNAIICKDETNEEHVKWIDFGGSGIDDSEPLAIYDLYNYRTPEPPLPEISIETDIFAFGCTIYEIETGSPPFFNETKEMDPGYVSDYVEERYKQGLFPSTENLRFDSIIKGCWHGRYGSMRDLRNELDLTGARRSPAVGFSGLLLGALFVWRVLRRKVVGVWKFLFSRWLPFTICGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YM36</accession>
    <name>A0A0D1YM36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NCS1 nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_06107</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236272.1">
        <property type="nucleotide sequence ID" value="XM_016380445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YM36"/>
    <dbReference type="STRING" id="91928.A0A0D1YM36"/>
    <dbReference type="GeneID" id="27333190"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06107"/>
    <dbReference type="HOGENOM" id="CLU_026016_2_1_1"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW16056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="56508" checksum="E28C250298EB8FDE" modified="2015-04-29" version="1">MPPTEKSFEGPTAQAGPHVHTHAAPHDLLDAVEQGTVQVDESKIMRGWTLQLERLLGVETRGIERVPESDRPAQASLADFVQIMLIWFSANLTLNNLALGLLGPLVYYVGLKDAMLIGAFGSIAGSIPTAYISTFGPMSGNRTLVFARYTMGWWPSKLTVLLNMVIMLGYGLVDCLIAGQLLSAVANGSMTVIVGTIIAAIISLVVALFGIKIFHIYERYAFIPQLLVLFILIGVAGPKFNAGSQTSGPSEVAIADKVSFFFLTVSGPIAWSPAACDFFVYFPPSCSRWAVFASTLIGLGISTLFMVLLGVGLGSGALVDTQWANAYDVSAGALVVESLSPLGTFGNFCAVILSLGLIANNIPGTYSAALGFQLLGRWFRLVPRWFWVIVSVIIYTICACVGRNHLFDIFEDFLALMGYWTIMWTTMTLEEQLIFRRKTGYNWDDWNKPSRLPLGIAACTAFCIGWVGAVLCMWQVYFTGPIAKLVGDGIDLGFPVSAAWSGMFYPPLRYLELKYFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMV0</accession>
    <name>A0A0D1YMV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING zinc finger-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236592.1">
        <property type="nucleotide sequence ID" value="XM_016380765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMV0"/>
    <dbReference type="STRING" id="91928.A0A0D1YMV0"/>
    <dbReference type="GeneID" id="27333510"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06427"/>
    <dbReference type="HOGENOM" id="CLU_029950_0_0_1"/>
    <dbReference type="OrthoDB" id="5405791at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056929">
        <property type="entry name" value="Znf_RING-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25080">
        <property type="entry name" value="zf_RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING zinc finger-like" evidence="2">
        <location>
            <begin position="400"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="469" mass="50942" checksum="4BFD1A4B77E69C7D" modified="2015-04-29" version="1">MARSVGNGEKRYRSMQEHIRRAHPDYYIPKLPATEESFQLMISTPPSQRPQQPTAAPAPARKGLYNQTADASEQAPLLEQVGAVTGPPSGTANAAVALAQLHNWDSEFDVFPESDYKREGSGGFELPSLRAQFSEDTLPPFQTSRTRELLPSILQSPGSRYSSLPPLQRRDKMQRSKKSSMGQNARKGKHERGKSREFSAKDFTRRLSVEGRKAMSAEPPTAAWVQGKRWEDLIEAATTATEVDDDRDLTPMPQSPNFPPSQGSTAMAMHAQTAAARRLSAADTPGGGDGAYKRSSLPPGFRPLGHHLQHGSAGKYSYNASPLQRALTPPPPDVLGANDSEPFPSVETVESAGSGANFHISASGLPTSNDTSPLQHYSEAHPYRHSQSSSFGSKSEVLEIYCASCGRPWLLKNSFACTECICGVCSDCVGQIISSPVMAVQPGLAPMRRGCPRCGVMGGKWKRFQLDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YN62</accession>
    <name>A0A0D1YN62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236707.1">
        <property type="nucleotide sequence ID" value="XM_016380880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YN62"/>
    <dbReference type="STRING" id="91928.A0A0D1YN62"/>
    <dbReference type="GeneID" id="27333629"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06546"/>
    <dbReference type="HOGENOM" id="CLU_025082_0_0_1"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="177"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="740" mass="83684" checksum="0346F3BAC66602E2" modified="2015-04-29" version="1">MEPISTITTRSSLTPQRQPDSPRPMTPASPMIEATTAFDQPVKLKSRHRLLQGLQRMSSSPSLAKLGRTRSSERVYKSGQKASISCVSLGSPTGSYSLSPPNPYTPQLSNGGYSTAPTTPGTPGSQQSYFEANSRLRPIDSNEAATASLPLDIRTGKPISTPLPEISEKPFVRRPNFDFWKDMPHELRLHIFRFLSPKEIIRVSSVSKQWHDMCFDGQLWTSLDCQTYYQQITSDALIKIMLKAGAFVKNLNLRGCVQLRDQWLSLGTRMTNQECRNLESFSIEGCKIERSSIHFFLLRNPRLVHINMPNMQNINNATMKIIACHCPQLEMLNIDWCSQIDTKGLRQVIQSCPNLRDLRASEVRGLDDNDFMLELFQRNTLERLILQHCESLTDEALQIMVHGLDPERDVLTDRPLVPPRRLRHLDISRCRRLTDRGVRSLAHNVPFLEGLRLCQNAALTDDALEDLLQSTHRLTHLEVEEAELLTNATLINLSKSRAASTLEHLSISYCEQIGDVGVLPLLKACPEIKSLCLDNTRISDLVLMEASEQVRRRGSTTKRSQIPKKGLELVAFDCANVTWAGVREILQGNGRVMQGRKKSVVQTVVEELGDEKKYRKVIEIQELLYPSQIIHLKAFYGWQQTVEEHYKRCVTGRWNAAARLEEKWAEWMVASEEVGVIGHGWSSRRRRRRAREAENRVRDDEDGTAQDTGTGDEGSGLDYATTRPPHAGRRRARSGGCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNZ8</accession>
    <name>A0A0D1YNZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237082.1">
        <property type="nucleotide sequence ID" value="XM_016378405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNZ8"/>
    <dbReference type="STRING" id="91928.A0A0D1YNZ8"/>
    <dbReference type="GeneID" id="27331139"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04056"/>
    <dbReference type="HOGENOM" id="CLU_004184_7_2_1"/>
    <dbReference type="OrthoDB" id="4161734at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="283"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="919" mass="106522" checksum="BA2395F5400B3B05" modified="2015-04-29" version="1">MPLWRLGLPIRWPTVTTPGPSRHRTSRRGSINEKDSYLDSDEDERVVTTPGPSRHRINWRRRTRENAPSLNSDEDERGPRLSRHKTNRYRCINTIIPRENDPHLDSNEYERIVTISRRHRRRLRANHRLSTRENDACLIPDEYYEIAPTPRHSRHRNDRRRSINTIVTCDNDPFSGSEEGLTSDLPAAENDKSSLPKWQSFFSFLRRLGHRREENSDENARLLDDEDADTSAQVPTHDESLYRALDRKTKEIRLLEIHPAQDPGTIISCNLRTVSLTNDRTSYDALSYAWGDRSAQRLIRINGELMSVKETLYTALRCLRESQRVRTLWIDALCINQDDLDERGHQVRTMKEIYEHAATTRVWLGTETIENDLAFDTLAYLGSAGSGVNHLPDHIIHGLQHLIIFKELLQREWWSRVWVLQEVVLAKEVVFHCGNRLLPMDILIRTYHVLQNSRNNGLLHALDNFESEEGLADFVATMSRGLDPIRNLTRFYQRPSHMSSEFDFILLLAKCRENNATDPRDKIYGLLGLAPPWVTELIEPSYDRSHKHLYTRTALQLMSKLNSSILFNQAGLSSRTATNEVIPSWVPDWSQQGNQWVDIELRLQQEKLFDASGYQLVLLPIHDDGVLMRGLPVDIVIATSDKMPSHCRHPEARACFARWESFSCTGLSSRNFRDQADGMYTESYWQTVLNGALPSNEQAKLRRLRFRDHEIFAEWRRRSQWRATQLESSQTLQSTDLLDEYISSTTRNRRLFMTAGGKLGIGPAGTKRGDYLYLLAGATHPCLLRQVKYRLDLYQLVGECYVHGIMNGEATKMAMTSTAPVSIAGLKKITNVRRRPTKTHGDECFERWIWNHYFAVFERRRSRVRRITLTRSSYEIGGGRYPDLSVLLARDLEVYEQEWCECPPVADDTEQSWRSVVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQR0</accession>
    <name>A0A0D1YQR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_04730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237752.1">
        <property type="nucleotide sequence ID" value="XM_016379075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YQR0"/>
    <dbReference type="STRING" id="91928.A0A0D1YQR0"/>
    <dbReference type="GeneID" id="27331813"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04730"/>
    <dbReference type="HOGENOM" id="CLU_089363_0_0_1"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW17536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24590" checksum="10806C29821D9DBE" modified="2015-04-29" version="1">MLSFLRPTQPRRTDISKLNPIPFEDGRSVVKFHPPGSSFAMTHTIPPTTPGNGPSILQPPFHYHISQAESFVVRSGRGGFWLGTSAEPFVTLSTDLGQSSTAAIPPKRRHKFENASQTDPLVVDVRLDPEKHDQEQRFFRNFFGYLDDCRKANSAPSLFQLMVFLHAADTPLALPVPNETLAFWVSRAFLIVMAFWGRWMLGYKDSYPEYYETPKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRX2</accession>
    <name>A0A0D1YRX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238192.1">
        <property type="nucleotide sequence ID" value="XM_016379515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRX2"/>
    <dbReference type="GeneID" id="27332254"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05171"/>
    <dbReference type="HOGENOM" id="CLU_2333619_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="98" mass="11339" checksum="3F08FF715D980B30" modified="2015-04-29" version="1">MSRYSRYQEQNLVYYMIKGYTKCNNYTASNVQYCDSYFSDIKFDSLKRQKEALKKSVKDQRAEVARLAAVATSAFAALAAAQEKEMKLDERLDKLTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSA4</accession>
    <name>A0A0D1YSA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238332.1">
        <property type="nucleotide sequence ID" value="XM_016376762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YSA4"/>
    <dbReference type="STRING" id="91928.A0A0D1YSA4"/>
    <dbReference type="GeneID" id="27329487"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02404"/>
    <dbReference type="HOGENOM" id="CLU_054974_0_0_1"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="250" mass="27919" checksum="EA80C7B53F6316C3" modified="2015-04-29" version="1">MIAKNPIPRRVAITRNYKLDGAWGQEMLDSFTDLIHAADKDALVQHFQPIDGGELPDASNFDLVILTGGTYDLTQPDFEAWVAHLLDWVRDVVSSHPKTKLLGICWGHQAISYALGGKIAYRGGGTLVDVVEIPLTETGRKFFTDFSSLSDMKAQRLHKFHKRIVVEPPRGFRYLAEDHEISMSDSDQVMTFQGHPEMTAKIAQGIIGGQDTSYLADPTPEGIAQLNRNLEKDEDGKEAFSRVMSWAFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSQ3</accession>
    <name>A0A0D1YSQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238517.1">
        <property type="nucleotide sequence ID" value="XM_016376947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YSQ3"/>
    <dbReference type="STRING" id="91928.A0A0D1YSQ3"/>
    <dbReference type="GeneID" id="27329672"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02589"/>
    <dbReference type="HOGENOM" id="CLU_120565_0_0_1"/>
    <dbReference type="OrthoDB" id="2819018at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046580">
        <property type="entry name" value="DUF6640"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20345">
        <property type="entry name" value="DUF6640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="149" mass="16687" checksum="0B954DA39C2DB1BC" modified="2015-04-29" version="1">MPTTTATTSTATTTTLGRSLLTLVALSTSVSCYLADWNETHVKNPRWPPHARFHNGQTMSMGLCLGTLTAYYTWRMTPNAAAEKDSLTTAALIGTLYWVTGMSAILYPGTKWEDPEFGERSPQKAVFGTHVVLCWIGWWLEMRRLRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSS2</accession>
    <name>A0A0D1YSS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238537.1">
        <property type="nucleotide sequence ID" value="XM_016376967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YSS2"/>
    <dbReference type="STRING" id="91928.A0A0D1YSS2"/>
    <dbReference type="GeneID" id="27329692"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02609"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="328" mass="35894" checksum="ACAD4102A747296E" modified="2015-04-29" version="1">MRVLLTGGSGFVATHVLQKLLERGHQVVTTVRSDEKGRFLLDLFKGKPVAYTIVKDIAAEGAFDKAVRSEPPFEAIIHTASPFHYNVQDNKRDMIDPAVNGTTGILKAIVKYAPSVQHVVITSSFAAIANPKAPPKVYTEEIWNDMTMEEALTTINPQAAYRASKTFAEKAAWEFVKTQKPNFGLTVLNPPMIYGPVIHEVASLDALNTSSKRILDLMLGNPRHGPVGSPIYVDVRDLALAHVLSIEKPEASGQRIFMAAGMGLEREMGDIIKRSFPQLAKNVRDDLVGDMPPYSINNSKAKEILGISYRSLDETVVDTVKSLQALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YT25</accession>
    <name>A0A0D1YT25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238662.1">
        <property type="nucleotide sequence ID" value="XM_016377092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YT25"/>
    <dbReference type="STRING" id="91928.A0A0D1YT25"/>
    <dbReference type="GeneID" id="27329817"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02734"/>
    <dbReference type="HOGENOM" id="CLU_360161_0_0_1"/>
    <dbReference type="OrthoDB" id="4160321at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="493"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="561"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="594"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="625"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="658"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="689"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="722"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="777" mass="86281" checksum="5BAEE1F2B5107AA3" modified="2015-04-29" version="1">MGDIYRTAKEVYIWLGIGDDDTNYALEHIEGKPQTRFDSGIFSTCVEKLFGASYWTRRWIIQEFSLAQERTIVCGGRLTKWRTLKSKSGNDVLRSDSSARQTLEGFKKVESLASGEKMSLLELMERFQNARCFEPHDRAFALRSIAENGDRLSPRYDESESDLYFRVLSTLPTERVFPTIPGYRWPHEAASRLQSCMPLKKQDLLKSLKDGPDDRLYTVFEYIGVILTVQDSVQNTQGQDAEDKFPSFPLKVQLQGPTKEFRGYGGLSSGDLIYSLQSTSRSPKGLYIAFGPRPTDPVVVGMLIQEPEGEKTIEFIRNIILGGVLVCRRINSGNPLHRRILCHISRTVLILLWLLDIGKLDCILSHQKEILDESVQGNLLCGCANDRATEHEDSSLEVLSSFAFEQDQTFWAEEITPPWTDLDQQPPQQQIQINENPQSDYALGFRYRKQQQVQVYESLPQSEDALDLDIVRGQVYHYFLSESSGNINFEDDDMKVPLWWVAYNGHATVVKMLLDAGANIFYRRPEQFYNAPPVVARSDINARENRFGKDLRRTRGLSGKHTHNPLHAASEGGHEVVVRLLLDGGAEVNAPGHNDHNALYHASVSGLRTVVKMLLDEGADINPPSGNAALNAASEMGHGTVVKMLLDAGADVNAPGENNHNALYHASASGHGTVVKILLDAGADINPPSGSAGLRAASEIGRVTVVKKLLEAGVDINARGELGQTPLQVAVMGIHKEVVRVLLKAGADVSGEDLGFVFRRSAKKVGVKVGRIRGREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUR0</accession>
    <name>A0A0D1YUR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase ROK1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase rok1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_03275</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239202.1">
        <property type="nucleotide sequence ID" value="XM_016377632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUR0"/>
    <dbReference type="STRING" id="91928.A0A0D1YUR0"/>
    <dbReference type="GeneID" id="27330358"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03275"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_4_1"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="129"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="154"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="436"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="239"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="624"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="677"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW18986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="703" mass="77845" checksum="534FF57E5C14DD2E" modified="2015-04-29" version="1">MNALQLLSRSTGLKSRTTKPSQPNQAPTSGQSINTNPISPSSGQKRKREDDVTATTSVSQDAPTTLSEDEIRQYQKKHKIKIVDLNRFRSAGKIEESRKVQKEQSRIFPQPLVSFSQLSRYNANKSLVRNVSEQAYFQPTEVQTATIPLLLKCLSNDDKNPDLLTIAPTGSGKTLAFLIPLIDKVSRSHREQSDSTEKHVSAIILAPTKELVSQIVEEGRKLCAKTGVRITATRKGMRLFGMQESAVEDDESDDESDDEDRDDDERDDEESQGDHPRESATLTKADIIVSTPLSLVHTLCPSWEEDETIPPNPLPTVETLIFDEADVLLDPLFRAQTLAVWSACTSPTLRISMWSATIGSNVEELAVQTIHDRQTRLKIRRSNRPPLLRTIIGLKDISLPTISHRLTYTATESGKLLGMRQLLHPSRSGTTSSGKDGNQVAAAAPLRPPFLVFTQTIDRAQSLYDELKYDIPAPAGGSSRIAVLHSSLPAHTRSSIMQNFRLGKIWILITTDLLSRGVDFRGVNVVVNYDIPNTVAGYVHRAGRTGRAGREGGVCVSFYTKEDIQYVKGIANVIAASEKAQTRHESGGGSRKASTSTSDGQVTGGEGLQPWLLHALPTVSKSTRKDLKLHGVQSRRAIHADDDEKTKRMKRKARIGTQSGYERREVNRKRAAIVHSMQEKSKKQKNTDHRTAEQENGDWEGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWW9</accession>
    <name>A0A0D1YWW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNA5</name>
        <name evidence="7" type="ORF">PV08_00386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240027.1">
        <property type="nucleotide sequence ID" value="XM_016374751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWW9"/>
    <dbReference type="STRING" id="91928.A0A0D1YWW9"/>
    <dbReference type="GeneID" id="27327469"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00386"/>
    <dbReference type="HOGENOM" id="CLU_003433_4_0_1"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="6">
        <location>
            <begin position="212"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="161"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="465" mass="51613" checksum="DE1BFFF9919AFD15" modified="2015-04-29" version="1">MDHTGSAEPFSIEHASALDATDVLPDYRSDFHIPTLADLKRPTLARPPTEGLSRPCTYLCGNSLGLQPVRTGDLVNVFLTQWRTKAVTGHFVDHTDSPLPPFLDIDDHAAKLMAPVVGALEAEVAVMGTLTGNLHFLMSSFYRPSKKGEGRWKILLEGKAFPSDHYAVESQIIHHGLDPDEAMVLLEPSNPHRPILPTEQILKTIDEHASELALILLPGIQFYTGQYFDIQRITAHAHARGILIGWDLAHAVGNVDVKLHDWDVDFAAWCSYKYLNSGPGAMAGIFINEKYGKVDTEGSTPKFWPRLSGWWGDDKSTRFQMTNKFVPRPGAKGYQLSNPSALDLAAVVSSLQIFNETSMTNLRQKSLRLTAYLEQLLDSMALRRPGLFDIITPRSPTERGAQLSIRLAPGLLDNVLEHLEDEGVIIDERKPDVIRVAPAPLYNTFTDVFRFCQVLESALDKASKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXI4</accession>
    <name>A0A0D1YXI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cation diffusion facilitator family transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_00546</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240187.1">
        <property type="nucleotide sequence ID" value="XM_016374911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXI4"/>
    <dbReference type="STRING" id="91928.A0A0D1YXI4"/>
    <dbReference type="GeneID" id="27327629"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00546"/>
    <dbReference type="HOGENOM" id="CLU_013430_4_2_1"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000021">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000026">
        <property type="entry name" value="Zinc/cadmium resistance protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="13"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="335"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="416"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="489"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW19971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="59644" checksum="D793D8013A43ACDC" modified="2015-04-29" version="1">MGFTKSQRIGILLGIDTVFFLIELVVGYAVHSLALVADSFHMLNDVLSLCVGLWAVRVANTGSSKMYTYGWQRAETLGALVNGVFLVALCLSIFLEAIQRFVEPQVVSNPKLVLIVGCLGLASNILGLLLFHDHGHSHGNEEHGDAVKHAEEGHGHVHNHDSETAAVADESGNIEDVLPQVKVAGFKGHESRKFTSSDEENTTVSGQSSETPHRKSHVHGELHGRHRRRTSGSLGGRGFGSVDNIHIHPASFRQEIIQAARFEEQSDESSEEGEALLDDEGAPNERSQIFGNGASSPSKGNQGYGSIGKRQSVIYNHADHFHNKPQGEHKGHSHGGHGHSHGDLNMRGVFLHVLGDALGNVGVIASALIIWLTTFPARYYFDPGISLVITVIILYSAIPLCKAASRILLQAVPVGLSIDEITTDIESLPRVISAHHLHVWQLSDTKLVASLHVKVDCEVEGSGSQSYMHLAREIRGCLHAYGIHSSTIQPEFTTPPPDAGASDGQPDSSQHAHSSKAASVNSEGPTCLLECGDKCADNKMCCPSDGKSSSQNGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYS7</accession>
    <name>A0A0D1YYS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_01016</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240657.1">
        <property type="nucleotide sequence ID" value="XM_016375381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYS7"/>
    <dbReference type="STRING" id="91928.A0A0D1YYS7"/>
    <dbReference type="GeneID" id="27328099"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01016"/>
    <dbReference type="HOGENOM" id="CLU_002738_3_0_1"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF82">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="362"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="323"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW20441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="621" mass="69224" checksum="E6F43476A09273A4" modified="2015-04-29" version="1">MSLPVRAAGGGQSSDAASQFLLTPFSDAVLSHLIVAYEQMPLEQRQQYPDESSFLRHMASDNSAAMSMPLNNDLTYPLSSYFISSSHNTYLSGHQLYGEANVEAYANVLKRGCRCLEIDVWDGDDSDTSSSDDEDDQADEHHDRGTDSKTKSSRWNRVKARAARMRSRSRSGSLTDRRKYPSSTATHPADLHTPSETDATARQTELPAQNRDFLSPQISPAFPPKVEPRVLHGYTLTQSITFRSVCHAIRDCAFESTDLPLIVSLEVHASLSQQEVMVEIMREVWAGFLVDITQCTKELNLPSPDSVRKKILIKVKWAPNSETGDSNNPLEHVASRSTDGGTEDSTTVSPEKKKASKILSALSELGVYTRAYSFKHFSQPEASIPTHVFSLSETKMFQIHGDPAYGPALFDHNKNFLLRVFPKGTRINSSNVDPTFHWRQGAQMVALNWQKMDKGMMLNEGMFAATGGWVLKPDGYRSTNPKSKDKPVPPQKRRLDLEIAFLAAQRIPLPADKDPAFATKVKPYVKVQLHVDTHGPPGEAKTIKPNSGIPHDSGSYASDESDQTTYKWRSLTCRTDCPDFGGERLKWQNVPDVVDELSFLRYAILPYVSFLNLEFPCSVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZCH0</accession>
    <name>A0A0D1ZCH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230953.1">
        <property type="nucleotide sequence ID" value="XM_016384351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZCH0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZCH0"/>
    <dbReference type="GeneID" id="27337119"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10036"/>
    <dbReference type="HOGENOM" id="CLU_046066_1_3_1"/>
    <dbReference type="OrthoDB" id="4110502at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="186" mass="20818" checksum="F9BF8D330C5009BF" modified="2015-04-29" version="1">MFDDADLMRRELEHLIAEQAQDVLLVMPSYGGIVGTQAAVGLGKVERQAGYDQRGERGGVVCLLYVCAFIWQKASICENGICVPMNPERIFYQDLPVDDQTKWATHIKPQPLAYQFNPMTKAAYENIPVTYLHCKNDQALPLHIQKFFVERCIAKVETFTCAAGHSPFLSQPDNFVKIVVKISGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZCL4</accession>
    <name>A0A0D1ZCL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_10081</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERT1/acuK family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230998.1">
        <property type="nucleotide sequence ID" value="XM_016384396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZCL4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZCL4"/>
    <dbReference type="GeneID" id="27337164"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10081"/>
    <dbReference type="HOGENOM" id="CLU_010748_1_0_1"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="325"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="525"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="617"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="540"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="623"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW10782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="698" mass="76505" checksum="7AC09483FDBD77B6" modified="2015-04-29" version="1">MAASDVEDGHSRSASPEDSGTENTQNNMAEPPSKDEKQKQNGSASTNPKDPNRPRRKKARRACYACQRAHLTCGDERPCQRCIKRGLQDACQDGVRKKAKYLHDAPNEALMPVVGGNLFNRSAAKQRSSTITSDTSSQQPYFQQPQNFNNFQNTPQQQMPPPLVHERSMSTTSFSQHSPLTTNFTGMTSQVALQSPVIGGDPATTNGMGGAPWSGALFEEPSPFNFDIASMNFGNHYGALEFGMLGHMATNAGETPPSDTTTHRGSMTQQYRMPLGSFSDSPTARQQLYNETAMLSDWSNNSDPYSAHNRHMAPNAFTIESNAAHWTSPDTSGTPGNGVKFEDSPLLTNQGLQAPPTHLENGNLTQPNNSLDSRPKQPPPISTPQLKARSQLPAKPLKRPRDPSSIYTSVTQPHSYTAGFHNLVAYCRKRFATQPSKTLAIAKSLASIRPSFIATTRTLNREDLIFMEKCFQRTLWEYEGFIEGVGTPTIVARRTGEIAAVGKEFQILTGWTKSVLLGRSPNLNVNRGHSGATPSGGSGTNTASRTAGFNTPTQRTTEAENGEKRSQPVLLAELLDDDSVVQFYEDFARLAFGDSRGSVLGRGKLLKYRTKDDELSQNLNAEAEARNEDGKPNGTDGRRKDSNHSRRNDMKKDGISGEKGMQKLGSADGKVDCTYCWTVKRDVFDIPMLIVMNFLPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZDX1</accession>
    <name>A0A0D1ZDX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_10507</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231423.1">
        <property type="nucleotide sequence ID" value="XM_016384821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZDX1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZDX1"/>
    <dbReference type="GeneID" id="27337590"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10507"/>
    <dbReference type="HOGENOM" id="CLU_021855_2_1_1"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112340" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="11">
        <location>
            <begin position="382"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW11207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="549" mass="57536" checksum="369451546CE1613C" modified="2015-04-29" version="1">MKGFTSVALAGAALFLTAKADVDPIVIKGSKFFYKTNGTQFYMRGVAYQQDYLGNGTTSGSSGGSDSYIDPLADPDSCKRDIPYLVALRTNVIRTYAIDPTKNHDECMSALADAGIYVISDLSAPGQSINRDTPSWNDDLYGRYTSVVDALANYTNTLGFFAGNEVSNNSTNTDASAFVKAAVRDMKAYIKQKNYRPLGVGYATNDDADIRVNLADYFDCGDRSQAIDFWGYNIYSWCGDSSYTESGYDERTAEFSSYNVPVFFAEYGCNTVQPRKFTEVGALYGPQMSPVWSGGIVYMYFQEANDYGLVSVDGNSVSTLDDFNYLSSELASVNPTGVNSASYNPTNTAAQACPTVGSDWQASSDLPPTPNQELCQCMYNALSCVPDNVSGDGIGELFGVVCGLGEGTCDGITANGTEGHYGAYEMCDPTQQLAFALNNYYQQQLTAGNGASACDFSGSAKTQSPATPTGTCAELISQAGSAGTGTVTSQPSGTGASGSGSGSGSGSGGSSSSSSAGIPGFSAPAHVGLLQVVSFLTVAFVSGAGMILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZEQ5</accession>
    <name>A0A0D1ZEQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_10737</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231653.1">
        <property type="nucleotide sequence ID" value="XM_016385051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZEQ5"/>
    <dbReference type="GeneID" id="27337820"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10737"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF51">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="53"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="524" mass="57282" checksum="E3B261ED05E9E28A" modified="2015-04-29" version="1">MEKAGEIHDGTKPGEAIFEDIAPKVEQARVAAEQEHQLSVWEALTKNKTVVFWCVFFAFSAVGWGFDAQVNGAMISVPQFRLTFGYIYEGQPVIPASWQSGFNSISSVGQFFGGFACSWLSDRIGRKKSLLMGLVFVTGGIFGEVFSSTRPAFLIGKLILGIGLGFYLTIGPLYCSEVAPVVLRGMITGGINFAIVIGQLLSNAVIKGFGDRDDRWAFRGPFAVQFLFVGILLVGVWFAPESPWHFVRQGQIEDARRSLQRLHGQDVDVTPRLAMIVQTVEEDMELSKSARWIQCFQGTNLVRTTISVGAFACQHLSGIVFVLGFSTYFFELAGIQTSHAFDLGVGVTACGVVGVIISWMAINTLGRRKLFVGGMIGMTIVLVLMGILDVVHTSAARWVQASCTVVYALIYQITIGCIAFALLGEVSTPSLRAKTVGLATACQAVFGTVMNIVVPYMVNPDKANLKGKVGFVFGGACLLGTIWSYFYVPELKGRTFQEIDHLFHHRVPPRKMGQYNLDEVEDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZFN0</accession>
    <name>A0A0D1ZFN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232023.1">
        <property type="nucleotide sequence ID" value="XM_016383400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZFN0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZFN0"/>
    <dbReference type="GeneID" id="27336162"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09079"/>
    <dbReference type="HOGENOM" id="CLU_048013_0_0_1"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="321" mass="36060" checksum="8BBAED80FF499142" modified="2015-04-29" version="1">MVGKSNLDIINECDNFPYQSDNPEAYDAAFKSYYHFKLEGCHVTLGYVPADVAAKLPSSKHWSLDQINRILTFQPRNEEGQPVEALEGRNLILAQYLQGVREQKVFRVLDGWRSELYPIYGPSKELILSMERSATPLFGVVTYGVHMTGYVQTGEGMKIWAPRRALTKPTYPGMMDNTVAGGLSTGEDPFECLVRECEEEASLPPDVVQPAKSCGTLTYFHIRDSRAGGEIGLCQPEIQYIYDLELPSNVIPKPGDDEAIDFQLLTIKEVQDAIAQGKFKPNCAHVLVDFFVRHGILTPENEPDYIEIVSRSHRKLEFPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZGC6</accession>
    <name>A0A0D1ZGC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_09281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232223.1">
        <property type="nucleotide sequence ID" value="XM_016383600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZGC6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZGC6"/>
    <dbReference type="GeneID" id="27336364"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09281"/>
    <dbReference type="HOGENOM" id="CLU_478198_0_0_1"/>
    <dbReference type="OrthoDB" id="5333655at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW12007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="570" mass="63673" checksum="EC0E4668C62ACA8E" modified="2015-04-29" version="1">MASTVATTMAHQMPPMPLPAMPRIRPPRMLKGTKSPNTDPQPPGAAPKGKWWVQGRWRNKGSNAGKHVEQTQALQVAKALRHETHGLDIYAYRHVRTNQVVYSLTRTLQEGKILKQLVFHGKKTVPASVRTDTWTPYFSIHFPPTPAGALSGLFAFQKLRELSLQRQLSPPDDLIRVTEEDVQIIKSKIGTPLELQELQAHDRLTAQIPKVGEILPKKLRGRRLMDQKATSVADAAFVLDWISSGPGPLERLTEVAVNRLARHHERTRRARRRINRIREDEGAQQKKIRDRITLALEQRDQGDKSHLPIPWKVLLQMSMENHGVIDGNGLADVENVMELRSAIADWQAYCELDAKDIDMDLWAKRQLTGREAERKAINEWFEVNDTPMTEAGSVWKDVAAAREAALADFDANEGASLKVDLAGKEKPEWAENKTVEMFWADLNDGLFASSWPENVVHGRLAPFGVAKGRVHGRRSSVLSSSVHVIGSNIDDGWMPRELAEPYAPAKRAVIEELGAGGSDGHQQDEGGRPGSSHVSAFREAEEESLGFWGRLRGMLGGGSKQRIAEEKQWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZI25</accession>
    <name>A0A0D1ZI25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232733.1">
        <property type="nucleotide sequence ID" value="XM_016384110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZI25"/>
    <dbReference type="GeneID" id="27336877"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09794"/>
    <dbReference type="HOGENOM" id="CLU_001265_23_3_1"/>
    <dbReference type="OrthoDB" id="2105912at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="82"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="554" mass="60969" checksum="1F3C3D2EC8B6B1D5" modified="2015-04-29" version="1">MAQFQSGVEAEVVVADKDAAALSPRQTVLRDDDQATKQEPEPEPEPEPEPEPARTLRQTLYACLTYVPPRCRYDPEKPFQFSMGLNLLFAFAGCFTVANLYYNHPILNLLADDFHVTDEEASYIPTLAQAGYAGGLLFICPLGDLLKRRPFTLWLVWFTATLWIGLCVTNSFTAFGAITFITSVTTVTPQLMLPLVGELAPPHRRASALSVVVSGMLLGMLCARLLSGIVAQYIGWRYIYWISFALQYIILILLYIFMPDYPSTNPDVRVVKKYPFLLWDIVKLVAKYPVLLQACLVGLFTATSFTSFWTTLTFLLAGPPYHYNSLVIGLFALIGIGSMTWAPVFARTFMEKHQPLLSVIIGELICLTGVVVGTYTGKSTVAGPIIQAIGIDVGLQTTQIANRTAIYAVAPKARNRVNTAYMVSVFVGQLIGTAVGNHLYARGGWITSGSASVGFVSVALLVGLSRGPHEKGWIGWSGGYDMRNDVPTKPQVVNKDAEADLQGQPQPQRQTATTGNAVEKRKDDDQNDDEQAAMDESSRSSQRTLREEARQVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZK11</accession>
    <name>A0A0D1ZK11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233378.1">
        <property type="nucleotide sequence ID" value="XM_016382675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZK11"/>
    <dbReference type="GeneID" id="27335432"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08349"/>
    <dbReference type="HOGENOM" id="CLU_052827_4_2_1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="106"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="240" mass="25840" checksum="BF39CDAAA5142F18" modified="2015-04-29" version="1">MGSMVEPPDTVPDLSDRQYAYFNSVPWCAALLADKRYTTVPSRFGQPSPDTRGDFFTRTLATDNTIVACLYQERRVDESADPERVSNVEEIRAFFATASGVNGFPGVAHGGFVAAVIDETMGYLIKAHLLASTTEVAPPPGPEPGPKAAKATVRVPLTSSDTMTAVMTGELTIRYKRPVPTGEALLVRTWVERVDGRKTYAKAVVEDGEGTVLTEGVSVFISLKDGKSPSTRRRAGAAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPP6</accession>
    <name>A0A0D1ZPP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235008.1">
        <property type="nucleotide sequence ID" value="XM_016381906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPP6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZPP6"/>
    <dbReference type="GeneID" id="27334660"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07577"/>
    <dbReference type="HOGENOM" id="CLU_003182_8_1_1"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="571"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="725"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="825"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="844" mass="93227" checksum="1D0E832E78488CB5" modified="2015-04-29" version="1">MPSTSSKVVEGFATKVLRIDLSERQATKDSVTRGESTYSVSTADTYVEEEPTTIGWVRELVPSKQDVGTYVRNLFPFTRWIGRYNVQWLIGDLVAGITVGAVVVPQGMAYAKLAELPPQYGLYSSFMGVLIYWFFATSKDITIGPVAVMSTIVGNIVNKVADEHPEVPGHVVASALAIICGAIVCFIGLVRCGWIVDFIPLTAISAFMTGSAINIACGQVPTMMGIKVKGFNTRASTYRVIINTFRYLGHTKIDAAMGLTALFLLYSIRFTCNQMAKRFPNRSKTFFFISTLRTAFVILLYTMISWLVNRHHRDDHVFAILGKVPRGFKDAKVPTINTDIISYFADKLPASVIVLLIEHIAISKSFGRVNNYTIDPSQELVAIGVTNLLGPFLGAYPATGSFSRTAIKSKAGVRTPFAGVITAIVVLLAIYALPAVFYYIPSASLSAVIIHAVGDLITPPNTVYQFWRVSPLEVIIFFAGVFVTIFSSIENGIYTTISVSAGVLLFRVVKANGHFVGKVKIHSVIGDHLIEDKFHDNKHVSDDDRAVREIFLPLDHNDGSNPSVHVEAPYPGVFVYRFSEGFNYPNANHYLDYLVKYIFEHTRRTNPDSWPRPGDRPWNNPGPRRGKFEEDRSYLPTLKAIVLDMSSVNNVDVTSVQNLIDVRNQLDRYTSPETVQWHFANITNRWTKRALASAGFGYPSAPTGEEYHRWKPIFSVAEIGGTSSAAAAAEAEQNRRLSRIPSDEEHGRGRTKSGGAIKSDATEDDHSGSSSPPELSREITNSKAYSRATQKRVAVVQGLNRPFFHIDLTSALQTAVATIEHQDQLRQAENKSTGISNDVDIKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQU8</accession>
    <name>A0A0D1ZQU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_05222</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235393.1">
        <property type="nucleotide sequence ID" value="XM_016379566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQU8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZQU8"/>
    <dbReference type="GeneID" id="27332305"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05222"/>
    <dbReference type="HOGENOM" id="CLU_018224_1_2_1"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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    </dbReference>
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        <property type="entry name" value="CALRETICULIN_REPEAT"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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    <feature type="chain" id="PRO_5002237834" description="Calnexin" evidence="9">
        <location>
            <begin position="24"/>
            <end position="570"/>
        </location>
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        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
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        <location>
            <begin position="290"/>
            <end position="334"/>
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        <location>
            <begin position="435"/>
            <end position="458"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="542"/>
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        </location>
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        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KIW15177.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="63017" checksum="844751B99C3E22F7" modified="2015-04-29" version="1">MKLNAAIAPALYASALLIGSTLAQEEVEPSSSVAERPTFTPTSLKAPFLEQFTDDWDLRWTPSHAKKEDSKSDEDWAYVGEWSVEEPTVLPGIVGDKGLVVKNAAAHHAISAKFPSVIDNKGKTLVVQYEVKLQNGLECGGAYMKLLKENKELHAEEFSNTSPYVIMFGPDKCGATNKVHFIFKHKNPKTGEYEEKHLKSPPQAKNDKLTHLYTLIVNPDNTFEMLIDNKSVKTGSLLEDFSPSVNPEKEIDDPKDKKPDDWVEQARIPDPAATKPEDWDEDQPYEIVDEEAEKPEDWLEDEPTMVADPEAEKPEDWDDEEDGDWIPPQVPNPKCEEVSGCGKWEPPMIKNPLYKGKWTAPYIENPDYRGPWAPRKIPNPDYFEDKTPANFEPIGAIGFEIWTMQSDITFDNIYIGHSVEDAAAFRAETYDVKRPIEDDEDAKSKPKPSEAPKSPSDLSFMDDPVTFVKEKLDLFITIAKKDPVEAVKFMPEVASALGGALVLVVAIVVGLAGLGGSAAPSKEDIKKTAQKAKEAAADAKDKVADAATSGAETVKAEVTKRTTRSSGNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZSA5</accession>
    <name>A0A0D1ZSA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016380091.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27332835"/>
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    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
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        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="252"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="252"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="155"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="250"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="127"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="333" mass="36868" checksum="6C1E915E5CD128BE" modified="2015-04-29" version="1">MESSKETSFPPASDIPLHRNAPLAPSQELAYRKKCIQLKRRLAEIEANNDSTRKRITQEKDHIKKLRLLRAILLNNLQEIMSTPAKKLTPEQLEKIGVLSNGSTDLAELAGTGITQESRNPRPDGEGLLDDSTDESEEEEPEPAERPERRRRVNNNYRETIMNANAPGESASTAYQQQTLPNLAPASSFSPARPHDHTGLTSSFRVSSGTPHAAGTSSSYPPPAESSHNGGSSPIYAGDPRAVYYGPGDIKPIRPDPPYVQFTAHMTPQLAANGEHPDDIPDRIQSEWDELTPDNRKLWEVRYQEQMAEYTAAMDIYKRASRRDTSSGFAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZU75</accession>
    <name>A0A0D1ZU75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236558.1">
        <property type="nucleotide sequence ID" value="XM_016380731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZU75"/>
    <dbReference type="STRING" id="91928.A0A0D1ZU75"/>
    <dbReference type="GeneID" id="27333476"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06393"/>
    <dbReference type="HOGENOM" id="CLU_018631_0_0_1"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="602" mass="67742" checksum="79C264E3E2D799FF" modified="2015-04-29" version="1">MLDGLPVEVIQHIVHHLPTASSIINLSLVSRKLQKVIARDDYACFRDFVKRSFPSIETPPLWREAARVLTSRSRAWDRRAFVARECYPPVDPEDMAEARSWTAVGYQPVIDCYETWTGSTWSERKEVLAWGAAGKLRMRVTKNGKVTWKSFTCPHDHVPTMDIVDVNLLRPNQTEKYSEHETAILGRISGDVVRVVSNDSGKLVQQSVYNTKPNGFHRMDVSKSPEPVLATCNNDGISLFPVDGTTSVVQPIDTVPLQTTRDVRNRIRCAKFLSDSAFAMCFQYLEGRERAPIDVYHINTAGITSKPFTQFFSDPLENVSNLRQSANTVVPLDDAAGISNLPGQLFLSGWSDGIVSLHDARTPIRPVSTYVDVVDDGQILAILPIGHERFLAGSSQNGCLKTYDLRMPGMRPYSYLEGRTQLSTSQAKPGDADTELSLSGSHKTRRDINIFLTPSVKYDERLWEPLRSGRRARRTERYRGCVYSLASPSPSSPTVYAGIENHVLQLDFVSTDDIRSGIEALVDPVLGLNDRSKDIFSFSCYERPREGYESTDPVLLRKQQGLFGERRESQIDKKESDVSKGVSEPGWDERWRLNTYSMNRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZX45</accession>
    <name>A0A0D1ZX45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237483.1">
        <property type="nucleotide sequence ID" value="XM_016378806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZX45"/>
    <dbReference type="STRING" id="91928.A0A0D1ZX45"/>
    <dbReference type="GeneID" id="27331541"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04458"/>
    <dbReference type="HOGENOM" id="CLU_049109_3_1_1"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="183" mass="20463" checksum="8B001A10EF9E639C" modified="2015-04-29" version="1">MATHLVSTTLLATALSAVSNILAQWLKAYREEKLSFSISLRPLLQFAIFTLLSSPPNILWQDFLEDRFPGYRIAAASETQILDRSNTARKLLFDQTLGAFVNTIAFVAAMAALKGKGAKAVQKRVERSFALQDTVPLMINSWKLWPLVALFNFIYVPVHRRVIVSSVVGLFWGIYLSLFAALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZXM7</accession>
    <name>A0A0D1ZXM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_04611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237633.1">
        <property type="nucleotide sequence ID" value="XM_016378956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZXM7"/>
    <dbReference type="GeneID" id="27331694"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04611"/>
    <dbReference type="HOGENOM" id="CLU_389315_0_0_1"/>
    <dbReference type="OrthoDB" id="4157088at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="693" mass="75434" checksum="0FC6FA9DBAB6A4DE" modified="2015-04-29" version="1">MSAPRPPQIPPIMTETTLTVEELPPEQSPRVSDMALWGDSTPFYQVTVTAASNLARNLVRTSPVFGPVRSTTDGNTNNNNTNGNSNAETNDAGENPATQAAAESRRWISTGILVATMNMIAIGINSMIGVMMPSILYNLDVLGFEWVFSASAIGAATCILFAGQLYTVAPFKAVYIVFTTLVLFGTVSVGFNTNMAYMYWTRLVFGAGIGGQQLGALLFLERGNTFMDKIRRDFYLTLSTSFGMILGPVFGALFVHNRSLYNWAFYTAFILGTMLFVGLAYLLPNKITIVGSAHWAYTHEMAGDRMYRRVDQPGCIFSSTSIFVLFMAFNFAGTVFPWTDGNLIALFGLGFGFLLLLIVQQYFKILSSSVTQAFPTHYLRSFKKTGLFLAVFLTAGIFQTVMPYTAFYQLVTQPEPSTIPTAFYLIFSLTAPFVIPAIIVHVHIGGGMVARYPVWPSYSVWTLISSVFILAGSVILFIDTPRIFPSGLPPTVARQFALACVGFWSSVVLPIANQVMDIYQPLAGQHHPFHNRVFVLFGFWLGAAVALTASGSIFMQHGTAALLALLRSPRSEYRFRAGYEDAQVLMLGYSFVRSGTESIFAQSIAELENTFALAFGPVLVFAALLFLLAVAMVVKKKCDGGLGAVPKEWTVQPDGTPGTELEERGVGGGGGASGARPQQDEAAVEGDNWPLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZK0</accession>
    <name>A0A0D1ZZK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_02430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238358.1">
        <property type="nucleotide sequence ID" value="XM_016376788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZK0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZK0"/>
    <dbReference type="GeneID" id="27329513"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02430"/>
    <dbReference type="HOGENOM" id="CLU_010245_2_1_1"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW18142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="628" mass="71598" checksum="853648E1E237DBEE" modified="2015-04-29" version="1">MSSHLSNGLTKGPRSEKENDANCTLADIPKSNTFTSKLPPDPQYPTPLDSHRAPRQKLGPRMVREALYTYVRPEPTEDPELLAVSRAALRDIGLADSEADSEEVKQVVAGNKFYWDEEKGGIYPWAQCYGGFQFGQWAGQLGDGRAISLFEATNPKTKVRYELQLKGAGKTPYSRFADGKAVLRSSIREFIVSEYLNALGIPTTRALSLTLCPKSTVIREQLEPGAIVCRFAQSWLRIGTFDLMRSRGDRNLVRKVATYVAEDVFGGWETLPASLDADKKDAHLDPPRGVPKDELQGKEGAEENRFTRLYREIVRRNAKVVGMWQAYGFMNGVLNTDNTSIFGLSMDYGPFAFMDNFDPTYTPNHDDHMLRYSYRAQPTIIWWNLVRLGESLGELIGSGDRVDDEVFVEKGVEEDFAPVLIKRAETIIDQTADEYKAVFLSEYRRLMTLRLGLKTQKEGDFEKLFSELLDTMEALELDFNHFFRRLSTVKLEDVSTKENRVQTAERFFHQEGVTGLNETNESGRERVGKWLDSWRERIVEDWGTEPSADEAREKAMKAVNPNFVPRGWLLDDIIDRVQNKKERDILQGAMEMSLNPFQDEWSWNEEIEKKYCGDVPRFKRAIQCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZZ1</accession>
    <name>A0A0D1ZZZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_02590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238518.1">
        <property type="nucleotide sequence ID" value="XM_016376948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZZ1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZZ1"/>
    <dbReference type="GeneID" id="27329673"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02590"/>
    <dbReference type="HOGENOM" id="CLU_039622_1_0_1"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="58"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="138"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW18302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="314" mass="33643" checksum="243C404ED8D0BEDA" modified="2015-04-29" version="1">MASTESAPLPTDLPLPTDASLSHGSLADLLPSHFTTDITQWLAEDTPSFDYGGFVVGSSPRTAQLLCKSAGVLAGVPFFDEVFRQLDCTVEWHHAEGEFLDPAKSGGKIKVATVKGPTRKLLLGERVALNTLARCSGVASKSRKMLELVRGAGYKGVLAGTRKTTPGFRLVEKYGMLVGGIDGHRHDLSSMIMLKDNHIWAKGSITNAVKAARAVGGFALKIEVEVQTETDADEAIAAGADVVMLDNFDGEGLKVAARSLKERWHGKRQVLLESSGGLTEANVKEYINNDIDIISTSAVHQGVPHVDFSLKIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0D6</accession>
    <name>A0A0D2A0D6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-L-arabinofuranosidase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238663.1">
        <property type="nucleotide sequence ID" value="XM_016377093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0D6"/>
    <dbReference type="STRING" id="91928.A0A0D2A0D6"/>
    <dbReference type="GeneID" id="27329818"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02735"/>
    <dbReference type="HOGENOM" id="CLU_009397_0_0_1"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18820">
        <property type="entry name" value="GH43_LbAraf43-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817:SF1">
        <property type="entry name" value="HYDROLASE, FAMILY 43, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35109" checksum="B3BDA6072B76CF88" modified="2015-04-29" version="1">MSNIPIADIDTPDPWMVRHNNLYYLTFTCGDRVDILMSRNVEDFRSCNKITAWHPPPNTPWSTDLWAPELHHINGTWYVYFCAAHLGRGSLSHRTVLLRSSSQDPMDAAGWTFLGPLQGIPDHWNVDATVFTLRGRLFCCYSGWPPGDFSDTQQDVFLVELADPEHALARTLTCISRAELPWERPDGGRRGVNEGPTWLSMAGFEGIVYSANGSWTSDYTLGLLRFTGGDPLQASSWQKRHAPLLKSCKDKGGPFGPGHASFIPAVDWGPAYPQGHPQKNEKGKAGTIARRGFCASTVTIFIHSPKAAAAFVVVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A1W2</accession>
    <name>A0A0D2A1W2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239143.1">
        <property type="nucleotide sequence ID" value="XM_016377573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A1W2"/>
    <dbReference type="GeneID" id="27330299"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03216"/>
    <dbReference type="HOGENOM" id="CLU_1073759_0_0_1"/>
    <dbReference type="OrthoDB" id="10496220at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="318" mass="36463" checksum="278CB83C6C480C2C" modified="2015-04-29" version="1">MSPSTTARISRIRDAVLCAALREYIRGQLDIALTPYPSLALRSRRATRAYETAVSIFLDESDEDGSLFDVRRADFDGELAARLDEAVNPSMHWAFSDEQRDRCHLLKEVIMGLTDQFTMLWVRELEKLKVTDARIQEMVGMNADVENDVLRRRVCFIFREDDDDYEEDEEEEEEEEKEREETYDNGKGKGKGKGKGKETDKTQVVPRDQAGDDTNDADNDDGHSRRRRRRHECENDKDNDNRVDVDALQDNDCIMYGKYVRTRDGDGDGDAAVEKPWVCLICANHTGTAHKGSFVRHLADKHGIRNVRKALRYLPTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5R2</accession>
    <name>A0A0D2A5R2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240323.1">
        <property type="nucleotide sequence ID" value="XM_016375047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5R2"/>
    <dbReference type="STRING" id="91928.A0A0D2A5R2"/>
    <dbReference type="GeneID" id="27327765"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00682"/>
    <dbReference type="HOGENOM" id="CLU_096188_0_1_1"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF3">
        <property type="entry name" value="CUPIN 2 CONSERVED BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="92"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="180" mass="19567" checksum="1574349E0559A09F" modified="2015-04-29" version="1">MADRVQQIVDLPPCKRHIATHDPNGKSVYVDSPPQQYMPVEGVGGMARSYSVASVPAKLANDEDLKSYRSNDAVTSWAQPSIVTPNGVNLLVVDLAPGAVSMMHRTVSIDHSICVIGEIEHELDSGEVVLLKPGDHIVQRGTNHRWRNASKTDPARFVAVTVACEPFEIAGKLLEEVHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A885</accession>
    <name>A0A0D2A885_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_01561</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241198.1">
        <property type="nucleotide sequence ID" value="XM_016375922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A885"/>
    <dbReference type="STRING" id="91928.A0A0D2A885"/>
    <dbReference type="GeneID" id="27328644"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01561"/>
    <dbReference type="HOGENOM" id="CLU_024407_1_0_1"/>
    <dbReference type="OrthoDB" id="1288932at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="40"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="290"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW20982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="539" mass="57634" checksum="616221CB768B4C9B" modified="2015-04-29" version="1">MVDAAIPYPEPSIDIILVQSSFLLLSNIVSTILDHVFYCGLVGQIVLGMAWGTPGSKLLSHTFEQAATQLGYLGLISIVFEGGLATSVKSVQENLFLSICVAATGISLPIVFSFSLLALTDASNLQAFAAGAALCSTSLGTTFSLLKTTGLTTSRLGIILTSAAMLDDVVGLIMVQVITNLGSHSGDFAASTLLRPILVSLGFAILLPLFCKFVSIPACKIWSKSKLPFPRWWDKVNKQNSLSLLYSTGVLIALVSAATYAGTSALFAAYLAGVFLSWFDEQIGDVERTGSADGAKQQSISDSEKINPNHADLQPCPSSRLPPPPPEEGHAKSETARSAEHPGGYIRLNGPSMCMYDQYYSPVVERILKPLFFGSIGFSIPITEMFRGTIVWRGIVYAMLMAFGKVCCGLWLVRFTYDSASKTKTTGKNKEKKQGKTVPRPKSLYPAWLLGSAMVVRGEIGFLISALAASNGIFAADGDNVRAPSEIYLVVTWAILLCTITIPIALGLVAKRVKRLQKQRQQNGDAAGQDPLGTWGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A9W4</accession>
    <name>A0A0D2A9W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241738.1">
        <property type="nucleotide sequence ID" value="XM_016376462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A9W4"/>
    <dbReference type="STRING" id="91928.A0A0D2A9W4"/>
    <dbReference type="GeneID" id="27329185"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02102"/>
    <dbReference type="HOGENOM" id="CLU_009665_2_2_1"/>
    <dbReference type="OrthoDB" id="2096480at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF4">
        <property type="entry name" value="BLR0106 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="446" mass="49638" checksum="866A69B3859FF2DA" modified="2015-04-29" version="1">MTLSKVIIVGAGPAGCVLALLLANAGINVELLEASDTLDDSPRASFYPWPAVRELERAGLLPEVRERGYVVSDGVSWRRVDGSLIGRMDASKVPYDRRLHGLPLGKLLALTREHLDRRPNATIHYLHKVTRLDQGQNSARVYVDTPEGEKLFEADYIVGCDGANSTVRRALFGEEFPGYTWPEQIVATNVYYDISKYGWGQGAFIVDKENFALIALLQNDGLYRVSYGEKVGLTKEEYEARQPEKFRRILPGNPEPKDYKLVSLNPYKIHQRCAQSFRVGRFLLAADAAHLCNPFGGLGLTGGLVDVGNLFDCLNGIHLGVADDSILNRYSEVRRKMYKEIIDPVSTQNLKHLLQDPDVALKEDPLFQNMETMQDPDAVAKMVSVSSPPIPPFCVRVQFVAFQKGINNIMHDFTQEYRQPPTREISASDIKTPSTTEVKLVGVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASU6</accession>
    <name>A0A0D2ASU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_11899</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230014.1">
        <property type="nucleotide sequence ID" value="XM_016386206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASU6"/>
    <dbReference type="STRING" id="91928.A0A0D2ASU6"/>
    <dbReference type="GeneID" id="27338982"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11899"/>
    <dbReference type="HOGENOM" id="CLU_010365_1_0_1"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238548" description="FAD-binding FR-type domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="440"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW09798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="792" mass="89127" checksum="71562DC7CB11F70F" modified="2015-04-29" version="1">MRLSAFLLVLSGLSGLTVAWDDPSGCVEGIRTVLAEVTFNASDPADYWTNLCATDMIVRSLWVAAKLYCTPFEIKAGGRTFGGYCEEYGSVELTPYSKVRPELTDEYINSLPLVGYSDIEAHTIWNTSIRLSEEVVMSGVHTYVYFEYEYILHERYGWALYGFWGGLLLVGIINRLITHFSQSRRANTSADLEGGQQVSKASKPIAVVSSIYHWFRANFIIPATFGSHHSRPVLWSTIPTRLETLVVVLFYILTFIMCCVSYYIIYPNFYYTKAQQAWRYIADRTGIMSYACLPWLFMFSGRNNVFLWLTGWSFGTFNIFHRHISRAATILAIVHSINYSVLEAGFDYYTESWKEQYWYMGNMATIAMSLILLFSMMWFRVKSYEVFLLIHIALSVVTLVGLFYHTKIFDGEYNGYLWPPVAIWCFDRAARIVRWMYCNIHVRSNSVLATKALATYNKDGDFVRLEIVPGSDFLKPGPGQHYYLYQPLKWKGWENHPFTLAAYETIGRAGAAAEVETNVTKEAIEKEIQAHPESSGSDTPTRSISVRSQHDVTAFPDAVGRQKLTFIVRPFGSWTRRLKEECLKSPDGVIAPKIFIEGPYGERSPLLSFETVVFIVGGSGIAGALPYMQQHIKAKEQGGEDAGDGKKLTTITRDIHFIWTTRQSTMIRDVAARELQPMLGRDDVHFHLHATSGKEAIHGSDSDSQASAVVETRKLAPVISAREKINITYGRPDIKASISEIIEEVNDAGSKGGRIAILTCGPAAMADDARAAVHAALKQGKRGVEYFEETFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT76</accession>
    <name>A0A0D2AT76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Tryptophan synthase</fullName>
            <ecNumber evidence="3 10">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_12009</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="3 10"/>
    <dbReference type="EMBL" id="KN847503">
        <property type="protein sequence ID" value="KIW09725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229941.1">
        <property type="nucleotide sequence ID" value="XM_016386316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT76"/>
    <dbReference type="STRING" id="91928.A0A0D2AT76"/>
    <dbReference type="GeneID" id="27339092"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12009"/>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_1"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="12">
        <location>
            <begin position="71"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW09725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="408" mass="44137" checksum="53972654B8FC8D54" modified="2015-04-29" version="1">MPYLESDESNLNENRTGEASGRFGRFGQFGGQYVPEALKESLIELDEAFVQATKDPDFWKEWRNLSPYMGRPSPLYHANRLSQHVGGAQIYLKREDLNHTGSSAINNALGQALLARRLGKRRVITQTGSGQHGVAMAAICSKLTLECTVYMGVTDARRQSVNVVDMKILGAEVVVVGRCAGALRDAMNEALRASIHDLDRSFYATGSSIGPHPYPIMVRTFQSLIGQETKDQMKDLIGRLPCAVVACVGASNCVGMFFPFRSDSDVNLIGVEAAGHGIDTNKHSAALGNGAVGVYHGTMTYLMQDEHGQINTSSSIAAGLNCPAVGPELAHWKDSARASFVTVTDAQALVAFQTIAQLEGILPSLETSHAIWAGMKMASTMKLEETLVICLDGKGDKDLEIVADRLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWH6</accession>
    <name>A0A0D2AWH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_10139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231056.1">
        <property type="nucleotide sequence ID" value="XM_016384454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AWH6"/>
    <dbReference type="GeneID" id="27337222"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10139"/>
    <dbReference type="HOGENOM" id="CLU_081619_0_0_1"/>
    <dbReference type="OrthoDB" id="4148961at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="232" mass="25701" checksum="835D2556DE441F70" modified="2015-04-29" version="1">MSTGSTTSSRRASLRRLSSPDALFLAPPHSHDPTDVSDVAALPTSMLLQLPEAVQESLWTLQESTSIVYASYLRLQELVEERFERLVELPFGQETGIVNYSEGAFFNYVNHVAAERRYLLEDAHTDWRHKASRAGLQQYGDLSLVFRGKEMTVSQWFTRLQAAEAFWIQAAKETELPDFESTVLEFQSQTTTPSSESADEIEDVGGVAVPAGRATVDTSRLGLGISQALAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYX0</accession>
    <name>A0A0D2AYX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.114</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.5.1.114" evidence="1"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232119.1">
        <property type="nucleotide sequence ID" value="XM_016383496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYX0"/>
    <dbReference type="STRING" id="91928.A0A0D2AYX0"/>
    <dbReference type="GeneID" id="27336259"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09176"/>
    <dbReference type="HOGENOM" id="CLU_023588_0_0_1"/>
    <dbReference type="OrthoDB" id="2387925at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="4">
        <location>
            <begin position="246"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="557" mass="60713" checksum="984662425A802E81" modified="2015-04-29" version="1">MAQGYRPERKGRQKRPANPLVRGVLAFCQKFGITVLDSTNSDIHTVTATAAADVRDSTGPRPGTGLAIGSENEEQPPNPSSLDLTPSVSLNDIPKRYTSYPPLLLLPHNFPAHNERWTAVYSALSGGDRNVLFQCIAETGFAGQNISRIAINAPIAAAAQEDGHGHSHSHDPDTGVDREEQPQLHQHRKKENFMRSPSGLVPVYGDWGGTTPLRSHSALSTSSISNVPTPQDFSNAFWTSTSQHRGITQCWAPLYTMFSRGNVAEKARILGTTPTAGGNSSGGARPRDGDSSGSGNGSVTFPGLTSEELREPLPETDVMDFYVGIGYFAFCYLTRGVRRVYGWDINPWSIEGLRRGCEANGWTCLVIRVDDHGNMVDQTAADVAKRINGHDHGQGQGQGQDPTGHEMQSEVTVRCVAFLGDNKWADKVMREITTAGVALNIRHANLGLLPTSRGSWENAVKAIVCGSGRSNNKNKSVERGGWLHVHENVDVREIEKIKTQITHDIDGLVKRQVSEHESERELAWAVSCDHVEQVKTYAPGVMHCVYDVHINPINPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B150</accession>
    <name>A0A0D2B150_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232854.1">
        <property type="nucleotide sequence ID" value="XM_016384231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B150"/>
    <dbReference type="GeneID" id="27336999"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09916"/>
    <dbReference type="HOGENOM" id="CLU_2885789_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="63" mass="6963" checksum="F0D71A56F54C482F" modified="2015-04-29" version="1">MHRPFALAPRDIGVKARIVMPSVSVPKKIAAAQGYGVEITFSGYTLHRRETAVSDIIHLYRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2B1</accession>
    <name>A0A0D2B2B1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233214.1">
        <property type="nucleotide sequence ID" value="XM_016382511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2B1"/>
    <dbReference type="STRING" id="91928.A0A0D2B2B1"/>
    <dbReference type="GeneID" id="27335268"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08185"/>
    <dbReference type="HOGENOM" id="CLU_366805_0_0_1"/>
    <dbReference type="OrthoDB" id="5288828at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113:SF1">
        <property type="entry name" value="DUF2293 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="169"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="748" mass="85149" checksum="3B362AB8804AF43F" modified="2015-04-29" version="1">MARVKQKTRKQAPSGGASTRGAQVAKERQKHTVIVEGTSKEHNKLRSVITFRADPPKGYTFIPAGNPELTAALKEFARRGDHKIYAVTTTPHAERHELSREVHRIGFHFPTSVVAQVCSHYGIRLTAGGKVIDDSKDDKLFQSVYQNGKRPKEEPKDQITINTEAKQTIKDLFPKMPDNDLFQIIKTAFQLGDNKVGTADEIPLIRRAQLSVVAHIRHVYTDYDKLLRRCPYNEARHAVEKDTLAKLIEWRGDDEVEDEATQRAADDLLREVIVISDEEDDDETDTDDIQIVQDNVRVEELPSTAYGAAVSRHPSPYHNHPGEMVSRSYQALPPAIQRYKPSDDTIAQRDRSRYAVWDQARRDYRAGISRQPVTVLERIYEPIDVAPKRVLVPLDPPAHSPTQVVYSRPPPAPMNSVEYEPRHNISQRSPRSYIRDANGTLYERIDDDRPRERVLEQDRHFENAARSILAPEVRVRARPRSPQRRVYPTHRQEDEYDSGKGSVLESIEGPQGAYSPAAMRLKQNDGYPAPHDTTVMREDGLGYRGAPNINRGDDGARVIKRIRLEDLPSPSEQRYARRESPIPIGYRERVYMPQPDPHFATSRAIEYDNQRSSPTLRPAASLGQGRYAQSIAEINRAAYSSTGASRKAEAMFEHRDPPQTRSQMPLYAQEHTRYLLPEPSLRRRGIENQPPTVVSRVYEPLDDLVYDSRLTSGQPVAPREVHRQAPARVYEYDESVPDNARSYVHLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3Y9</accession>
    <name>A0A0D2B3Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233859.1">
        <property type="nucleotide sequence ID" value="XM_016383156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3Y9"/>
    <dbReference type="STRING" id="91928.A0A0D2B3Y9"/>
    <dbReference type="GeneID" id="27335917"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08834"/>
    <dbReference type="HOGENOM" id="CLU_007784_1_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="868" mass="96203" checksum="62604993F7C25C53" modified="2015-04-29" version="1">MIEEQASTKLDNNDQAEHQDQDTAEPPPKKAKRFQYTREKPFACTQCDSKFTRSDLLVRHERLSHDAERWGRNGRAEHRNSVSQSTSSQRPLDANVSANLDMTDAASLTSPAFSTSQNMVGAAFMTPNPNPPTAATPNNHDLSFATLLMAAEHAQPQNNQRHAAMPQSNQLSNSIFSVPDQFMADSDAQASMQAPSNHLSNMGGMGLGGFDFDDSLQDLANFMDNGALSSYHFSSMISAEQPIPFFSPESLTQPMDIAPSAGQQPVSRPVQNTDRQEDSSSFSRYGSRLPSLQPEESPTAHQNEQDTPLRPLHDLNMDDRQNVAVKLAEFAHAVPSNFQLPSRLALSRYLAGYVNGFHEHLPFLHIHSLSVNNCSIELILAMAAVGAQYCFEGQKGVELFNVSQSIAIQRIRQRDAKLAASHRSADTPSTYSSQQKYSEAFHVEGTPRSGSLSGCLGLPSQPEDPAADKEELMQTAQALLLLMAMATWAKHREILREALAIQSVLATLVRDDGFKSPPLTDNITWSEWIRRETTKRTKFIVFCFFNFHTIVYNIPSLILASELDLPLPCNAAEFKAPTGAKWKEIHSRTPPEVGFQTALHRLFSRTNTEVNTYNSSLGNYVLVHAILQHIFFVRHTSRYCLDHDGELRNDDVAAIEQALRNWQMAWKRNPESSLDPMNPNGPVTFNSTALLRLAYIRLNVDLGPGRALDTRDPTQIANAFRDSPSVKRTPKLVRAVLHSAHALSIPVKIGIHLVAQTQTFMWSIQHSLCTLECAFLLSKWLEALSLPDAGPSITNDEQKIVTLVKTMLDETEFAMPVDVPMGTPAAMKYLSAGVLRVWAQVFRGSQTWAIVDVIGSSLNIYADMLEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4E2</accession>
    <name>A0A0D2B4E2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233741.1">
        <property type="nucleotide sequence ID" value="XM_016383038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4E2"/>
    <dbReference type="STRING" id="91928.A0A0D2B4E2"/>
    <dbReference type="GeneID" id="27335796"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08713"/>
    <dbReference type="HOGENOM" id="CLU_007078_2_3_1"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="647"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="747"/>
            <end position="765"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="425"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="701"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="876" mass="95090" checksum="C1DD63F706913697" modified="2015-04-29" version="1">MADEHHPSPQHESQNNSNTSSTTHSRSQSAHGKTGQKGLHKVKFMGDEDGPEQGDSSRGRSIPEIRLAESEDVADSPMTPTDSYVGRVNVAAAQAQSRASRLAFRLSNSHAGREKTSSGSNTPLISNQKGYASPDSSPPTKPLSDWLVNVDDIPLASLGKDRRPYTIHDDTTDDDDDDDDDDDDEESKKSKSLKRHDENIAEARHLLRTLTNGHRGSAWQPQPRSGTETPAADKHLHDLEYVPPPEDYRPGVFGAILSSKLADLQHQDYTYPRYTDDSPQNHPGARAEPKDGRSRGHHRAHSDTYSPSYTPSGMSTPSGRLTPSKRPKWYEKPNHSMGSMATLVASASATSAAPAAPGTTAQVPRPQRPHLPRSKSSSSMIATAVDMIKHPGNHFHHKSEQILRAEEERVINDVAEILACRKYLKKLARALMAVGAPSHRLEEYMKTSARALGIDGDFLYLPGSMLVSINDKVTMSTEVTLVRETQNVDLGKFKDVFSTYKCVIHGKLTAQEGLDELDDILKAPKRHSTVIQILVYGIAAVAVGPFAFSARPVDFGPSFLLGCVLGFLQLVVVTRSTQFSHVFEVLATVIIAFVARGLGSIYHNKHPVFCFSAIAQSSIALILPGYTVLCAALELQSKSLVAGSVRMVYAIIYSLFLGFGILIGSVLMGVIYRDAQNSVTCDMPPWWNVPQPDYRLIYVKFIWVPIFAICLAVINQAKWRQVPVMTLIAMAGYQANFWVSVYLANNIQVANAIGAFVIGCLANLYSRFFHGLAAAAMLPAIFVQVPSGLAASGSLVAGITSANQITHNATGYSVINNGTAGFQAAQDDSSGGLYSGTIFNVGYGMIQIAIGISVGLYLSALVVYPIGKRRSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4J8</accession>
    <name>A0A0D2B4J8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
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    </dbReference>
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        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="2">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="339" mass="38578" checksum="B97B8C4C4C51A8DE" modified="2015-04-29" version="1">MFVETFTDYDDIELCYRVSFFEENHRNRGDSWSLRQTGVYQRFSGSPGQSAGIILQPSQRIRPWIEEYLRSAKFRSDYPMMLHVLMLAALAATWTSYVQHLSTQLRELDEKVSFSSEPKCRRYDYEVCFADCQTLHLFRSKLLRASLVIDDNLQLASNFASLTSECGSGMTDTQERELSNNIRAYTSEMAIHKRNIAFLLDESTNTASLLSKLLEARMSTSLRVINQTMESNLSLIRNTSTNTLQENLTIATIAKQGTKGSRKIHALTLIATLYLPATLVATVFSSNLIQWKDEGDDPTTGSHFKAHYTVVSEFWIYVVSTLVLMVTTLVIARVLERVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B581</accession>
    <name>A0A0D2B581_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">PV08_06640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016380974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B581"/>
    <dbReference type="STRING" id="91928.A0A0D2B581"/>
    <dbReference type="GeneID" id="27333723"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06640"/>
    <dbReference type="HOGENOM" id="CLU_051118_2_2_1"/>
    <dbReference type="OrthoDB" id="3533814at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="10"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="257" mass="28699" checksum="4CFBD8C4F2E281BA" modified="2015-04-29" version="1">MAAFDGLDGYAKVASLMSRYNEYGIFRSFKALNMRNLLYFQAELTQLEQELKEIVRTDQLSDSEARHEALLQCQRLSAFKKPTKYKIDFFRDWQLLMKLRGGQSIISDDQNAWNEANEDDLVTTDNPNKVDATSTWISETLVPNYHWCIGKYHKTPVDWDPVAGIANYSDKAITRLVDTFATVVSCVFSVLSIVALNSVRSVSIRIGLTAVFTAVFCLCLAVLAEAKRIEIFAATSAFAAVQVVFIGTTGDCSCPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B643</accession>
    <name>A0A0D2B643_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1754-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234584.1">
        <property type="nucleotide sequence ID" value="XM_016381482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B643"/>
    <dbReference type="STRING" id="91928.A0A0D2B643"/>
    <dbReference type="GeneID" id="27334233"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07150"/>
    <dbReference type="HOGENOM" id="CLU_098435_1_2_1"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17141" checksum="907A46E292B068DE" modified="2015-04-29" version="1">MAPNDYASVGSGKLKLKGVKDAKIDKKKKKKSSSKPSDGTADRGEDNTFHDKSVMLRKLEDEDAQLAKEERRNLAAVDGEEVGPGAGIKDDEERQVVKTEAEKRYEEQRRKRLEDRLKREGVKTHKERVEELNRYLSSLSEHHDMPRIGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6X8</accession>
    <name>A0A0D2B6X8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234646.1">
        <property type="nucleotide sequence ID" value="XM_016381544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6X8"/>
    <dbReference type="STRING" id="91928.A0A0D2B6X8"/>
    <dbReference type="GeneID" id="27334296"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07213"/>
    <dbReference type="HOGENOM" id="CLU_1454432_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="186" mass="21802" checksum="146962364DCE979C" modified="2015-04-29" version="1">MRFALAPRRAVFRVRMQSRIDPVEIVNKYFTYFDVDVDGDFYTREVTPKRSAITYIVLDLRSKTCPTVNLDIVKYDLYEVKKKRAGVVLVPVAYKYYDFARRRLRSYPWGRLKHPSRRFTAAFDLPLRPFRSSLRSRQDESSGRRVKMAAAVPHRSATPPRSFLGLHEQSLRVKRTSRVTHVVFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B729</accession>
    <name>A0A0D2B729_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_07264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234696.1">
        <property type="nucleotide sequence ID" value="XM_016381594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B729"/>
    <dbReference type="STRING" id="91928.A0A0D2B729"/>
    <dbReference type="GeneID" id="27334347"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07264"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="204"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW14480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="362" mass="41164" checksum="7B3E0636855D564B" modified="2015-04-29" version="1">MTDIVRTTPDGYQEIRTGLGWRRVLSPKSTEATTELPVIDIGDTVHPDLECRRAVAKKICAAAERTGFFYIRNHGVPDALIESIFDEAKRFCHELTLEEKMELDTEKHDHYYGYYPIKLNPDQPSGAKLNESINYGYEPSTDPEAADDTNNGDNWWPPEERLPGHQRNVKLFMSEVLQLARRLMRMFALGLDLDEHAFDYLATRPYSILKLAHYPGTIDGSEEPSAIRPHTDYEILTLLLQDHIPSLEVLSNTGQWIQATPIPGTFVVNIGDTMAMLTNGLFVSTMHRVLNTSRRTRYSVPFFLGANQEAVIKALDKYVTPENPAKFQPMTSGEYIRRGLQAVYSKPNTEIVHETIEIKAHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7H4</accession>
    <name>A0A0D2B7H4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_07414</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66168"/>
            <dbReference type="Rhea" id="RHEA-COMP:16963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234846.1">
        <property type="nucleotide sequence ID" value="XM_016381744.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2B7H4"/>
    <dbReference type="GeneID" id="27334497"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07414"/>
    <dbReference type="HOGENOM" id="CLU_001828_4_0_1"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000049">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000054">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="16">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="260"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW14630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1320" mass="146397" checksum="B16D1A51C30D9854" modified="2015-04-29" version="1">MAQKPAKLVDNDQIQSASLHNPLPIYLKAYVWPFTILWPIFLAFYLNEDLYDEYIDGQEWTFVWIATITTLQSLAWLSTKWNVNLDTAFTTTKATKVENAQLIKVIPIVNSGLPSICKLEKGKDGRIFFLFQKRRFDYSSEKGTFAPLSYTLDGQKKPLLREFQLTKGLTSAAEIETTQQHYGDNTFDIPVPTFMELWKEHAVAPFFIFQVFCVGLWLLDDYWYYSLFTLFMLVAFESTVVWQRQRTLNEFRGMSIKPYDIWVYRERKWVEIKSDKLLPGDLVSVGRTQEDSGVACDMILIEGTAIVNEAMLSGESTPLLKESIMLRPGDAPIEPEGLDKNALLWGGTKVLQITHPAASEDAPDSIPTVKSGVPSPPDNGAMAVVLKTGFETNQGSLVRTMIYSTERVSANNAEALWFILFLLIFALAASGYVWQEGVRNNRKRSKLLLDCILIVTSVVPPELPMELSLAVNTSLAALSKFAIFCTEPFRIPFAGRVDIACFDKTGTLTGEDLVVDGIAGLGLGKANRPTEADGAQSTITKVPDCGVYTTLVLATAHALVKLDEGDIVGDPMEKATLTALNWTLGNNDTLTNVPPSKSKKAHSTAGASHIVQIKRRFQFSSALKRQSSVATVSITDPKTGRRGKGTFVGVKGAPETIAKMLVDVPPKYEETFKYFTRNGARVLALAYKYLSTEAELGQKRINDLSREEVEAGLTFAGFLVLQTPLKEDAIRAVQMLNESSHRVVMITGDNPLTAVHVARQVEIVDRDCLILDAPEDDDSGKKLVWRSVDEKTIIPVDPTGAIDPKILETKDLCVTGYALAKFSGQKAFKDLLRYTWVYARVSPKQKEEILIGLKDLGYTTLMCGDGTNDVGALKQAHVGVALLNGSQEDLTKIGEHFRTTKMKEIYEKQVQLMKRFNQPAPPVPPGIAHLYPPGPSNPHHEKAIKAIAEKKGISLENGDAETGGIETITSPGAQAIQQSSTHLTAKERRQQEAQQKAASWADKFTSSMMENELDDGEPPTIKLGDASVAAPFTSKLANVVAIPNIIRQGRCTLVATIQMYKILALNCLISAYSLSVIYLAGIKFGDGQVTISGMLMSVCFLSISRAKPVEALSRERPQPNILNAYILGSVLGQFAIHCATLIYLSRVVYSIVPPSDEIDLEGEFEPSLLNSAVYLMQLIQQVSTFAINYQGRPFRESIRENRGMYWGLLSCSFVAFAGSTEFLPELNDKLRLVPFRSDFKWTLTTLMIVDFCGCWVVEQVFKYLFSDFRPKDIAIKRPDQVARDEKRKREIMEKAEQERIAAIEERRGVANSTGPAAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8C1</accession>
    <name>A0A0D2B8C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipocalin/cytosolic fatty-acid binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235131.1">
        <property type="nucleotide sequence ID" value="XM_016382029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8C1"/>
    <dbReference type="STRING" id="91928.A0A0D2B8C1"/>
    <dbReference type="GeneID" id="27334783"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07700"/>
    <dbReference type="HOGENOM" id="CLU_094640_0_0_1"/>
    <dbReference type="OrthoDB" id="9975758at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21901" checksum="0421011338F7B262" modified="2015-04-29" version="1">MATTRLNFRAPSTSTAAVATVGDNNNNDDDHDTSSPKFTPPSASFLHGKWYVTHSTLPMWKTNRNVTITYTPLPNDAAVLDDLVEYQPKSSDRRKKVKGYDTPSGDVPAAYGWRGKGWLMIASSKWQVIGYGDEDEGWCVTYFEKTLFTPAGIDVYSRRKTGASPDLLSRITEEMKNVRDGNVRKLAADMFAIDHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8F0</accession>
    <name>A0A0D2B8F0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_07727</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235156.1">
        <property type="nucleotide sequence ID" value="XM_016382054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8F0"/>
    <dbReference type="STRING" id="91928.A0A0D2B8F0"/>
    <dbReference type="GeneID" id="27334810"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07727"/>
    <dbReference type="HOGENOM" id="CLU_007683_0_2_1"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000142">
        <property type="entry name" value="Similar to FCP1-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="156"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="540"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="421"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="728"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="771"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="855" mass="95697" checksum="4AF054C2247EFBBB" modified="2015-04-29" version="1">MLLRLPKNLHYPLTITKVEKRVGEYLARNDDLFLYSYTAKVTEGTRYGDEEQEVERKFVTHFPSTLEGTIKGWRVWEGDVLTHPVDICEIEEECPHEVQFQGMCTNCGKDMTTLQAGSDTSDIDRAPIRMAHDTQHLTISKEEASKIDEEAKRRLLSSRKLSLVVDLDQTIIHAAVDPTIAEWMKDPENPNYDAVKDVRSFQLVDDGPGMRGCWYYIKLRPGLEEFLQHIAQLYELHIYTMGTRQYAQQIANIVDPDRKYFGDRILSRDESGSMVAKNLERLFPVDTKMVVIIDDRGDVWKWSANLVRVTPFDFFVGIGDINSSFLPKKQEIQSTPKADYVLPAENGGTDNDETKPAQSNGFAEDGVPNIQEGTSPLEQFMAMSGGDDPAVREQQTKGQEEIIHSQLEDKPLLKMQLEQDEKDEAEAAAANGESAVPQSTESDTSESSESSEGGSGPSKHKARHSILKNDDEELIHLESSLTKVHSAFFAEYDRKRLGGKGGRVAELTGKRKAPLPADDDQSNAVDLMFVPDIKKVMPAMKTRVLSNVTVVFSGVLPLGTDIQTADISTWAKTFGAKITDRISRDVTHVVAARPGTAKVKQAVKRGIKVVSTAWLIGSMQQWRKLDERPYLLEGAGRQRHETSSDLGDLLERSNVGASDFLLSSSEGESTGLETEDDQPLRKRLKLDIKNGDSPDDEEFDDLVDDGSPITLNQDEWADIDAELKEFMGSDAESESDTDSVNSALSFRERRSVKRRRDEGDGDLDVEHPSTVKKNGTGSALKTVANASSERDSNSTNTPSTEFREAQIKEEQRQVEEAQQREEEDEEDSDDELARELERELEEADAEEDDRPKEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8G8</accession>
    <name>A0A0D2B8G8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235171.1">
        <property type="nucleotide sequence ID" value="XM_016382069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8G8"/>
    <dbReference type="STRING" id="91928.A0A0D2B8G8"/>
    <dbReference type="GeneID" id="27334825"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07742"/>
    <dbReference type="HOGENOM" id="CLU_054962_1_0_1"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07739">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050855">
        <property type="entry name" value="NDM-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951:SF14">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="52"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="308" mass="34358" checksum="66DE7F109F0BE67E" modified="2015-04-29" version="1">MKSIFGWGLLASTSGIGFSEFVTQKNGLQVDVYHQPPAVVAYQNSTDLSFSPTAFTLIHGEHDAVLVDSPATMAQGKALAEWIHETIPGKQLKTVYITHGHGDHFFTGPIIQQNFPGAQVVAKKDVYDHMLQQYEPTFFNSFWASLFPGGQITDSPFSAKVLPENGTFYLEGHVLQAVEVGQSDTYNTTVLHVPDLDLVVGGDVVYGHCHQLFAEDSTHELRQEWLNSLDKAAALNPEFVIPSHMQPHDGYQPSHINETKRYIHVWEQLLACSSSWEELEAKVKKAFPLRTGNFILRWTCQAPFNAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B962</accession>
    <name>A0A0D2B962_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH-response regulator protein palI/RIM9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235416.1">
        <property type="nucleotide sequence ID" value="XM_016379589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B962"/>
    <dbReference type="STRING" id="91928.A0A0D2B962"/>
    <dbReference type="GeneID" id="27332328"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05245"/>
    <dbReference type="HOGENOM" id="CLU_016694_1_0_1"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254318" description="PH-response regulator protein palI/RIM9" evidence="7">
        <location>
            <begin position="32"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="653"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="81490" checksum="4A16CF53F4BB5235" modified="2015-04-29" version="1">MLRPATPLTVLLLISFVLLLLSVISTPIVKSIPIATYRGVNFGVFGYCTTKSCSDIRVGYTTDEIFGSDDNGDFNLPASTRHSLSSLLIVHPVAAFCNLVCLALAAAAHLHSPSHSARYLLGLLILLLPTLLVTLLAFLVDILLFVPHLQWGGWIVLASTILITASGVVTCAMRRTLVSRKARKKRIAENAEMSGENFYNRQAQESKLPAQTFDSAEPTMPMVNGAPGADRLPNFATFESGKPDEDRQPLRSQGVTSDGTTLRDGASDNFYPPPSVRSNSRPPYDERRDQYGNPIPRAAGAMMPPRQASEERTPAGSYREGSVPPPGSRGYGSRGRGKYPSRGAYSPRGGGYGPRGPPPPQGYPGRGGFFPEMRGGYTGRGRGGYPPTAAIGAIGAGMAAGGMMADGQRRPPPGYPPDGGQRTTPPDSYPDSMGPFGPVAGSTPYVENPAPNRADAMSPSVYTTGPEEHLAPYGARAQSPARSGYGSRMQSPVGTTRQQSPPPVMPPLPSAQPTELPTSSRTNSRSQSQDPYIPPRSQWNNVSHEDFAQPGSPGRYTSPVELPSTGSHVGGYSGPSRRPRVNSGGSDVYYEDVDPRFASDPEPMPAIPPNPATQPTTVPPLLTAGQPQYRPDSLALPPSNSYEDLPGARSPAESETSNFTSVSQRGINPNWRPGNGGEFASLGPPRRREHQMRRDVLLAGNPDFEIPGMGGSGRMSSRGGRDGMRGGMMMGGGPPRIPPASAVGMGSDGRYPMGPPPPPAGPGNMREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9A3</accession>
    <name>A0A0D2B9A3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235451.1">
        <property type="nucleotide sequence ID" value="XM_016379624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9A3"/>
    <dbReference type="GeneID" id="27332363"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05280"/>
    <dbReference type="HOGENOM" id="CLU_145533_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="151" mass="16546" checksum="7EC2C94D98231D8F" modified="2015-04-29" version="1">MATSSQAARITKLLRQAESNISSIPGSDNSKYAALGRLQEARSLLKAEETREKRESDAPESTRQETPKASKKKRTKKKGKAKQEPEPRSGNTANDTQQESEEPSVAQGNPEKPIWMTVVKKGNKEKPGNVTLRTAKGTSQQRKRAGNTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9Q8</accession>
    <name>A0A0D2B9Q8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2 7">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_05763</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2 7"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235929.1">
        <property type="nucleotide sequence ID" value="XM_016380102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9Q8"/>
    <dbReference type="STRING" id="91928.A0A0D2B9Q8"/>
    <dbReference type="GeneID" id="27332846"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05763"/>
    <dbReference type="HOGENOM" id="CLU_032482_0_0_1"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF4">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="11">
        <location>
            <begin position="276"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="219"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="309"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW15713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="387" mass="41822" checksum="B7610AAF0B1861A5" modified="2015-04-29" version="1">MSGELVAQDLYFSSETGIITPNYYFREDGVERIDMNGYVVAPGFLDLQTNGMQGIHFTQLAGQKGHAEDDEQKLQAVSEMEIAHGVTGWWATVPTVAKDRWKQIVPTLTPRAFSSGAELLGAHVEGPFLNESKKGAHSAQHLQIPAEMSLSELYGDANLKGPIKLITMAPELPGSTALIGQLQEEYPHIVISLGHSAATYDEGVAAVQIGARALTHVFNAMNPLHHRDPGLAGLMATGKCYFSIIPDGIHLHPAVLTMCMRTDPQKCVFITDSIELAGLLDGVHPGHGQIPGNQYKQGNKVTIEGTNTLIGSCCTVDDCVRNAVAFSGCNLAEAVQCVTENIADMMGENKRGKLEPGRRADFVILNKDGFVQETWMSGNRVWPVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAK8</accession>
    <name>A0A0D2BAK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_06039</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236204.1">
        <property type="nucleotide sequence ID" value="XM_016380377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAK8"/>
    <dbReference type="STRING" id="91928.A0A0D2BAK8"/>
    <dbReference type="GeneID" id="27333122"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06039"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW15988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="326" mass="37020" checksum="AE550D13CF178D41" modified="2015-04-29" version="1">MSVENVTLASGHKMPLVGFGLWKVPADKAADIVYNAIKQGYRLFDGAYDYQNEKEAGEGIKRAIDEGLVKREDIFVTTKLWNNYHKREHALQMAKAQNEAWGLGYIDLYLIHFPIALPYIEPEKLRYPGWWMDAEQKTIETARVPLHETWQALEEVVDAGIAKSIGVSNAQGQTIYDIMAYARHPISSLQIEHHPYLVQPSLTDLARENKIVVTAYSSFGPQSFLELPPAFRERPQQVPLLFEAEPVKKAAERTGKTPAQVLLRWSTQRHIAVIPKSNNVGRLQQNLEVTNFDLTDDEIKAISALDQGLRFNDPGFYLHKPLRIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAS7</accession>
    <name>A0A0D2BAS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235916.1">
        <property type="nucleotide sequence ID" value="XM_016380089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAS7"/>
    <dbReference type="STRING" id="91928.A0A0D2BAS7"/>
    <dbReference type="GeneID" id="27332833"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05750"/>
    <dbReference type="HOGENOM" id="CLU_024079_0_1_1"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174">
        <property type="entry name" value="DUF946 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174:SF5">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249647" description="Vacuolar protein sorting-associated protein 62" evidence="1">
        <location>
            <begin position="18"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="40354" checksum="142A54BE81B535E1" modified="2015-04-29" version="1">MFRLCFVPLLLASLSFSFPLGSSLGNIQKRDVPDFVRRYGRLHNYYFYYTRSKGAGWNQALLTSYLHPAPLAYLCSSEIYFPSDIGAQIAHTYPEDGSGNTITPPAPLTLSNIDTLNSFSGGGTDVYLTSDEGIRALPSWFRGSRPQSDGSTPSIVGCAVVTVSKPNGVLDAFYFYFYAYNQGNWVLGLPALEFGDHVGDWEHTMVRFVDGAPTAVYYSQHSGGEAFTYAATQKGPDGVRPLVYVANGTHANYAIPGPHDHTIPNLNTLAGPLTDHTDRGVLWDPVADAYVYGFDNATGVFEAYNGVDPVGWLNFAGSWGDNQLPDNTPGQIDVFGERKYVAGPTGPRDKGLTRTGVCPDGKSCTVRSVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAS9</accession>
    <name>A0A0D2BAS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236269.1">
        <property type="nucleotide sequence ID" value="XM_016380442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAS9"/>
    <dbReference type="GeneID" id="27333187"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06104"/>
    <dbReference type="HOGENOM" id="CLU_004495_0_1_1"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF9">
        <property type="entry name" value="AMINO-ACID PERMEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="61159" checksum="E0B72EE156D5A5AB" modified="2015-04-29" version="1">MAMNVETTTGPLNETELRRHSVGMLEIQDAHGRRRTVQLDELSAADRALAEQFGYKPVFKREFGYLSTFSFAVSISGLFATTATTFVYPLEAGGSASAVWCWLISGAGCMCIACSVAELVSAYPTCGGLYYTVSRLAPSEWVPSISWVTGWINLLGQVAGVASSEYGSAQLLLAAVSIGRDFNWFPTTNQTVGVMAALTVLCGLVNSLSTYWMEKMTKTYVIFHFAVLISCAIALLAKTENKHDASYVFTHVEGDAGWTPIGFSFLFGFLSVSWTMTDYDATAHITEEISQPEIKAPWAISLAMACTYVLGWLFNIVLCFCMGDPAEILASPIVQPVAQIFYNSLGKGAGIFFTVSAFIILQFVCFTATQALARTVFAYSRDKLIPMSWVWTKINPLTQTPLYAVWISVFWCIAINLIALGSYIAIAGVFNVCAIALDWSYVIPIVCKLAFGKFKPGPWHMGRFSPYVNAWACIWTFFVSIIFILPTIRPVTAQNMNYAIVFLAFILLCAAVFWYLGGKRYYTGPLIEAEIQEGEIASPSLSGDEKKEAKSGTPDAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBB2</accession>
    <name>A0A0D2BBB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dimethyl sulfone monooxygenase SfnG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236111.1">
        <property type="nucleotide sequence ID" value="XM_016380284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBB2"/>
    <dbReference type="STRING" id="91928.A0A0D2BBB2"/>
    <dbReference type="GeneID" id="27333028"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05945"/>
    <dbReference type="HOGENOM" id="CLU_027853_1_2_1"/>
    <dbReference type="OrthoDB" id="2558704at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046306">
        <property type="term" value="P:alkanesulfonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01094">
        <property type="entry name" value="Alkanesulfonate_monoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024014">
        <property type="entry name" value="DMSO2_SphG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050172">
        <property type="entry name" value="SsuD_RutA_monooxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04021">
        <property type="entry name" value="LLM_DMSO2_sfnG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847:SF4">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="34"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="410" mass="46422" checksum="2076F79771F0432B" modified="2015-04-29" version="1">MAGTTSIPILNGHSDDTTGGINSDPGRIKFAYWVPNVSGGLVISKIPQRTNWDLASNVKYAQTAEQVGFEYALSQIRFMAGYGAEHQHEPVSFSQAILHQTQKLILIAALLPGPWNPAVAAKQIASIDHYSQGRIAVNIVSGWFKTEFTSIGQWWLDHAERYRRSREFIECLKGIWTQEKFTFKGDFYQFHDYPLSPKPLKWDNRPHPEIFQGGNSIDARENAATVSDYYFMNGNTLEGFQTQIADVKERARREGREAEVKFALNGFVIVRDTEEEAIRVLQEIQGKADPEAVEAFRKEVQNAGASTANKQGMWANSKFEDLVQYNDGFKTKLIGTKEQVADRILLLKSLGVNVLLTAFLHYDEEIERFGKEVIPLVRKLESEGRGKDQEDEIKRTGDVYKAREPNETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCQ0</accession>
    <name>A0A0D2BCQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236611.1">
        <property type="nucleotide sequence ID" value="XM_016380784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCQ0"/>
    <dbReference type="STRING" id="91928.A0A0D2BCQ0"/>
    <dbReference type="GeneID" id="27333530"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06447"/>
    <dbReference type="HOGENOM" id="CLU_094283_0_0_1"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="218" mass="24933" checksum="0E0812C5B1D5869C" modified="2015-04-29" version="1">MVNLAKRMRNFQPLLAVQYGKGAAVLPPPPSPQLTRLTMKYPRTEWSLSNQGPRMFAKDSLPRLKYHNPSLPIRVEDTQASTLELTFESTDKAALETLQKRIDSEKLEDEWTEIQTKLQEPTDLNSTSTPLPIFTRNGILALKGKHSREIWRWFQHKTACKDVSISPQDELLRRKLQDTARKSEADRVLVKAGMDALRKQQAELKKAREAAERLTSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDY5</accession>
    <name>A0A0D2BDY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237031.1">
        <property type="nucleotide sequence ID" value="XM_016378354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDY5"/>
    <dbReference type="STRING" id="91928.A0A0D2BDY5"/>
    <dbReference type="GeneID" id="27331088"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04005"/>
    <dbReference type="HOGENOM" id="CLU_080826_0_0_1"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22575" checksum="BB23C37A853965ED" modified="2015-04-29" version="1">MSGLEKALFNLKFTSKQLNRQAAKADRDARAEQAKLKKALTQNPPQPQIARLYATNSVRNSQQRIQLLTLAARIDAVAARVQTAITMRTVTGSMAQTVKGMDVALKSMDLEKIGAVMEKFESQFEDLDVVAGYYEGVAGGVESQQVGVEGQGEVDALMNRVADEAGVELSQEMEQKVPEHELQQAESAERAKLEEGLGDRLRALRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEI3</accession>
    <name>A0A0D2BEI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Urea active transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_11905</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230020.1">
        <property type="nucleotide sequence ID" value="XM_016386212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEI3"/>
    <dbReference type="STRING" id="91928.A0A0D2BEI3"/>
    <dbReference type="GeneID" id="27338988"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11905"/>
    <dbReference type="HOGENOM" id="CLU_010778_2_1_1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="666"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW09804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="74413" checksum="49F37111D844082D" modified="2015-04-29" version="1">MAESSGFQIAAPLSSGLGYGLLVGIGSAFAIGMSTLSWFLSRYMNEIQDSEMFMTAKHSVQTGLIASAVVSSWTIATTLLGSTTYGYSYGISGPYWYAAGASVQILLFSVAAIELKKGAPNAQTFLQVVKVRYGTAAHLVFCAYSQVYQLITTVNLLVGGSAAYSAMTGVNRDASCFLFPIGVVIYTLAGGIKATFITDWVHTVIIYLIMLYSLFRIYVTADVVGSPDRMWELLKEAGRLHPIEGNAHGEYLTMGSDGGGYIGLVFIGAGFAAAVDSQLFQKAIAADPRSTSKGYIIGGLSWFTIPFVLASTYGLTAAATEHLPSFPTYPNRMNAYEISSGMAMPYAALAVNGKGGVIAILLMVFMAVTSAMSSETVATTALLTYNVYQAYINPKASGKQLLFFSHCVTVGFAIVAAAVAIAFNHGGFSVSFLITAIGIFVDSAIIPMACTIMWRKQSRLAVIVSPLASSAAAILAWFLTAHTHFGEISITTLNQNLPLVAGNMMALTGPIVLTPLLTYIKPDNFDWQVFKDQIKRGDDEHVTVDGHVVTTHDAEAQAVLDERKRHEDENERILLGARNRSIGVSIVLTLVLTLLWPIPMYATNYIFSKPFFRAWVAVLFIVAFLAAGAITLLPIWDARKVMALIVKRWFKKDEVYAAEAISEVVTSRDAKGASENTTPAQNSMEKIDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BG43</accession>
    <name>A0A0D2BG43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_05143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238164.1">
        <property type="nucleotide sequence ID" value="XM_016379487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BG43"/>
    <dbReference type="STRING" id="91928.A0A0D2BG43"/>
    <dbReference type="GeneID" id="27332226"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05143"/>
    <dbReference type="HOGENOM" id="CLU_007383_12_2_1"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF7">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW17948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="356" mass="38905" checksum="217EA1DD2AA0DFFB" modified="2015-04-29" version="1">MTNSSVNIHSTGATGYIGGDSLYLISQTHPEWELTLLVRDEAKATKMRNQYSQARIVIGDLENSELLMEESRKADIVYHFAHCDHEPSAHAIACGLAQHSPDSPGWWIHTSGTGTICYPTFRAKDFGLKREEVFNDWDDIGTLTNAPDDAPHWPTEKIVLKAGTEHGGRVKTAIVCPPCIFGPGRGPVNTRSIQAYELAREILIAKEGVQLGPATNIWTEVHVQDLSMVYLLLGEAAAQGGGSATWGKEGFYFAENGEFDFQALSKAVTEAAYDKGLISSPKIRIMSVEESERSGIMQRWGGMLYLIGTNARCRAIRARKLLGWAPKQRKLLAEAPCIVEAEAKALGVVPGGRVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHQ0</accession>
    <name>A0A0D2BHQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_02438</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238366.1">
        <property type="nucleotide sequence ID" value="XM_016376796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHQ0"/>
    <dbReference type="STRING" id="91928.A0A0D2BHQ0"/>
    <dbReference type="GeneID" id="27329521"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02438"/>
    <dbReference type="HOGENOM" id="CLU_060216_6_1_1"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW18150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="153" mass="17069" checksum="806B0686A79BFAA7" modified="2015-04-29" version="1">MSNEQTFIAVKPDGVQRGLVGDIICRFEKRGYKLVALKMVSPSKEHLEKHYEDLSSKPFFKGLVTYMLSGPIVAMVWEGRDACKTGRSILGATNPLQSAPGTIRGDYAIDVGRNVCHGSDGVESAKKEIALWFTPEEVQSWKSAQFDWIYEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIC8</accession>
    <name>A0A0D2BIC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_10414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231330.1">
        <property type="nucleotide sequence ID" value="XM_016384728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIC8"/>
    <dbReference type="GeneID" id="27337497"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10414"/>
    <dbReference type="HOGENOM" id="CLU_039184_1_1_1"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23637" checksum="EF0C47438885706F" modified="2015-04-29" version="1">MGSKIFVIRHAESKHNVDHNFDQLDPGLTELGLQQAEQLGRTFPDPDRVGLILTSPLQRALQTTLSAFSNILDKRYFDPQSSQGVSGGVELLVDADAQERSDLPCDTGSDRDTLANTFPRLDFSTLPESWPRKDGPYTPDDEALRARAGNLRQRLRELDESLNDPNKAIVVVTHGVFMKFLTQDETIDLPKAGWSVYYARQDAEGGSVLVPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIT1</accession>
    <name>A0A0D2BIT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239054.1">
        <property type="nucleotide sequence ID" value="XM_016377484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIT1"/>
    <dbReference type="STRING" id="91928.A0A0D2BIT1"/>
    <dbReference type="GeneID" id="27330210"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03127"/>
    <dbReference type="HOGENOM" id="CLU_011694_4_2_1"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057720">
        <property type="entry name" value="RRM_YTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="105"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="4">
        <location>
            <begin position="231"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="59948" checksum="529883B3DFA25317" modified="2015-04-29" version="1">MKHCAASASFNKSPPPPPPPPAREFSILQRPDMCGQWTPLELSTSSIWDQVFLAKMQNFRSQHDDAWEEDSRPSSGGLRRKTTFSERINVSTKQNRTSTRQWGEYALWVGNIPSNTTVMSLRDYFAEAAPAELLTISYNPDAKYAFVNFSTEAARIAAIGKAASQLFDGRRLDCRIRRDKASRSTKVSYGLNSSDRQRRLSISPERPASMWNKVEELKQHPETDASQRGRDKYFILKSYSLEALYQSLATNVWHIPKRHVERLNHAFQFCVSHTDDRVSLFAFFQTGSKVYFLFSVNGSGEFFGYASMTAEIRQDEMSVTTPGASHRPSSDASTESLPIHMRSYGADAQPTEFRHRALSTTSSDASYGSIHYEPERRRIIWEASHHTSDHQSVTPEDFSPDTMTPVTPSESSGRSFRDFPNTANFEYASSPSMSMALPPQAAAHPTGSELQHLSEPCRIKWHSTVNLPFDEVRGLRNPWNENKEVHVARNVTAVEPDAAESLLERWKRKDEARRFQHSQDAISKAWPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ08</accession>
    <name>A0A0D2BJ08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238761.1">
        <property type="nucleotide sequence ID" value="XM_016377191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ08"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ08"/>
    <dbReference type="GeneID" id="27329916"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02833"/>
    <dbReference type="HOGENOM" id="CLU_033724_0_0_1"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39361" checksum="30C55495CE777DFD" modified="2015-04-29" version="1">MPLKDLLKKKDKIDDERVLPPPLPQANEFTFVRTDTNTEEYINPPAFDDVRDPSPASPSNPSASRRSFSRFRKSVSPAGSDASSPEKERKDRRRLSERLHLNKDRSGSTSSVNLPPDLPDIRDAYNESGDRQDKEAQWEERATKLATKIPVLPAKSPTSEMESLNIGTRARARSVNDPEGDIDIQKAIQLHESGDLSEATEMFRQLAESGNVLSQVLYGLSLRHGWGCTPDPARAVTYLSAAATNSATIESDALKAGMKKGGAAKGELVLAIFELANCFRHGWGIPVDKVAARQYYETAANLGDTDAMNEAAWCYLEGFGGKKDKVSDSWCFLPALNNYYDALRIPYHPLRPDPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ41</accession>
    <name>A0A0D2BJ41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238806.1">
        <property type="nucleotide sequence ID" value="XM_016377236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ41"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ41"/>
    <dbReference type="GeneID" id="27329961"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02878"/>
    <dbReference type="HOGENOM" id="CLU_066963_2_1_1"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239053" description="GOLD domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="30"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="230" mass="25310" checksum="734B1DE4D88F64B7" modified="2015-04-29" version="1">MHFPLATVLAAFSLLAPSQALYLYIDGTSPKCFYEDLPKDTLVVGTYKAEAYSPATSTFRTTSDLAIQVTVDEVFDNDHRVVTQTTTSSDAFSKFTFTAADPGLHRLCFTPSGPAAISVGGWFSGSAGSTIGGVKLTLDMAIGATSKIESEDKSKIDSIVHRVKELNGRLTDIRREQVFQREREAEFRDQSEATNSKIVRWTLIQLGVLGVTCAWQLSHLRSFFIKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLR7</accession>
    <name>A0A0D2BLR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232335.1">
        <property type="nucleotide sequence ID" value="XM_016383712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLR7"/>
    <dbReference type="STRING" id="91928.A0A0D2BLR7"/>
    <dbReference type="GeneID" id="27336476"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09393"/>
    <dbReference type="HOGENOM" id="CLU_019271_1_0_1"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000640">
        <property type="entry name" value="Serine/threonine-protein kinase PRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="353"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="690" mass="75689" checksum="1DD88C0B726D7D1F" modified="2015-04-29" version="1">MTDPRVASQKHPRSQPRSQDAHDGLGEFRFPRNQTQESEAWAEDRFLLTPPAHTSHVDPIQQAISHTNNRAFQANQHASFPGAQLSASPDRYQAIPQETALLLGGLHIRTDGNVMKRSNSGRSVDSDSLLRSSSSASSLPPRHPSIRTQLHSSAGSVSPGATISSPQIAAMLDITPLPSPTIGTFESLRALSKTRSRGSSISSLKSTKGDSSALPGATAAVGTLSPTSPRRKGYGVLRSPPKSNLSDEQGVSSDEPHPRSVSEYVPEALAVPRPRNVAVSTTGPHPALTDTPMHREEFIGPDRRAAKTYERPATPPPAAPATKPVDEDEPAAKRPRLQVFHAKSITTGESRLYEAIRVLGVGTFSKVYLAVRLIHHDRQDSVDYRQESMNMAGVKARSRRLVAVKVVEHGPAGGADANRIEIGLKREVDILKSIQHPSLVHLKAFGTDGGARALLVMNYCPGGDLFEVATKYREVLVPTLVRRIFSELVSAARYLHQKFIVHRDIKLENVLLNIPVRVHPDVEDWQTLDRAVVTLTDMGLSRRIPEPPESPLLSTRCGSEDYAAPEILMGQPYDGRQTDAWALGVLLYALMEGRLPFDPLPGARGDPATLRARTPHRIARCEWAWVKYGDEDGNWDPEKGREFAGADLCVDGLLKRNTRRKPLAELREMPWVKEGIQVDGGLRWVEEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMF0</accession>
    <name>A0A0D2BMF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_00683</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with creA, creC and qutD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240324.1">
        <property type="nucleotide sequence ID" value="XM_016375048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMF0"/>
    <dbReference type="STRING" id="91928.A0A0D2BMF0"/>
    <dbReference type="GeneID" id="27327766"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00683"/>
    <dbReference type="HOGENOM" id="CLU_008279_0_2_1"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000075">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase creB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="54"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="547"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="574"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="699"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="713"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW20108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="728" mass="82488" checksum="D75DF8917A8EB330" modified="2015-04-29" version="1">MSSFFGKLKSQNAPAPAVGTTPMKRDPNAPVPTPLERMLKNAGPLRNDGSDKFFGMENFGNTCYCNSILQCLYYSVPFREHVLSYPRHSTPESIAEAQAHAPPRVTPSQANGAAKKPPGPSSSRNAGAPPQQQKPEDKDSPEYKKKQALAAGPILNMSYGNARSYDMPENLFTTLKDLFEAVVVDRNRMGVISPIKFLNTLRKENEMFRSAMHQDAHEFLNLLLNTVLENIEEHDRTLNAQKLIEQTQLPVEEPESMITKNDSATVSFPPVLPTPTTHSNTRWLHELFEGTLTSETRCLTCENVSHRDEPFLDLSVDLEQHSSVTACLRRFSEEEMLCERNKFHCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDLQRLQKLFHKVVYPYHLRLFNTTDDAEDPDRIYELYAVVVHIGGGPYHGHYVAVIKTQDRGWLLFDDEMVEPVDKNFVRNFFGDKPGLACAYVLFYQETTIEAIRKEQQMEGKRRASQDLPNGLASDARHSAELHRIQTVNPMASPESVSNDGNHHYATLDHAMTAPEFMPNGHVQRPQSPTLTSDRPVSPVIQSKKEKAREEKLRKATEKQAEKERQEAERQRRKDLAAKLSEAHKKQEAELKAALEASKASKAEEDKRHALERSTTSPNGSHHSGLDRFKRSKSLRFGSLTKRDKPYPKPSDENLATSSASAETDTPDLEKDNHQDSPPKEKKNRFSIRKKSFGMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN81</accession>
    <name>A0A0D2BN81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240614.1">
        <property type="nucleotide sequence ID" value="XM_016375338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN81"/>
    <dbReference type="GeneID" id="27328056"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00973"/>
    <dbReference type="HOGENOM" id="CLU_339480_0_0_1"/>
    <dbReference type="OrthoDB" id="4119912at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="837" mass="91808" checksum="C1CDF137DE708348" modified="2015-04-29" version="1">MPFPSLRRRTVNESPKTSSEQKTSPSPNRGRSSTLPRLSPRRSITAMFDSAKRGRTARQVHNHLVGHLRSPTRSESDAIEGDLYPKYDASNPGHDPQRAIDASSVEQPKQFRRPPSPHPLKFSGLSLMSKANQAISDQKQSELSSSDKSSPPKTFLGAITSLFYKENKEAAKPQVEGTGVEAPSSTGRKSPKKSVRFRPENTVVDTEKRSAPIDIPTQPPLLPPIDLTRTPMLTAMRRLQDTIPTGRPQPSNVLRNSAVFRHARETTKASDILPNMSSKLPVEPFPLPTQAVPIVPPETVKPLDDPFRDSPEEIDPEIRRAMREQYGDRYYRRLSSISSSLEIASGQAVFGTGSKAQMFEGTADHGTVHILENKEDTSAGVSATAPGSKFNTPHPDPTGQSLWAAQQYDTESELNPPDIFMDSDSSSTSSGEVLTMTIPKKTRPLTQAATITSGSLAERQIVASDNHVITKDPKHCMDTAALAHQQSSNSDAPMVSLTNQKQKQGAANDRKFDYQNHLQTSYPTPMSPSQTRAVGADLQTPCVLPPALIPLPMSPSQIELSPYTDQYGWCPFHEELFVHAVKRMIEPGTIDFRELVCKEGGLRFFWDQHQLPPNTAPRKDTKGLSLWETDDLLDAVQGEPSVQQSSTASKLGVSVNAMSPTHLHHTALQHLHGEAETDGDFDNSSVLGLRGSFSDTEVEPRSWLAGQVKGWTNTEASDTFSGLSMEGNISTESVHSASIQPKTIELPLRLKREVTENLNTSEEDREISENESGSESPTDMLKRTAASHMEKVSAHGHKWSPRRHNDEGGSDETGGTTFSSAQSESGDEDEDYCRGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPY9</accession>
    <name>A0A0D2BPY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240781.1">
        <property type="nucleotide sequence ID" value="XM_016375505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPY9"/>
    <dbReference type="STRING" id="91928.A0A0D2BPY9"/>
    <dbReference type="GeneID" id="27328223"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01140"/>
    <dbReference type="HOGENOM" id="CLU_100590_2_2_1"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="167" mass="18778" checksum="6A52370CD8A03454" modified="2015-04-29" version="1">MVLRIRLARFGTKRAPVYNIVLAQAKSARGKKPIEVLGTYDPIPRLPLATPDTPEYLPDGTKFVPRRYKDIKLDTSRTKYWLGVGAQPTEPVVKLLSMIGLIEPKPSSPLPRTTQQQQQQQQQQQQQQQQQQQQQRETSSTSTSTSTSPAESIPTQQRQQKPTTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ71</accession>
    <name>A0A0D2BQ71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4385 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241299.1">
        <property type="nucleotide sequence ID" value="XM_016376023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ71"/>
    <dbReference type="GeneID" id="27328745"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01662"/>
    <dbReference type="HOGENOM" id="CLU_079668_2_0_1"/>
    <dbReference type="OrthoDB" id="2589819at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025494">
        <property type="entry name" value="DUF4385"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14328">
        <property type="entry name" value="DUF4385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="20219" checksum="CD1A961DD3127D8E" modified="2015-04-29" version="1">MPKTSEKTLLTPNPPLDTPALTDAGLCYSYEIARGEIGVLSFEPYKSLILPYWAFRTVPIAQKSAQVLWTIFQSYVERDDLVGADMTRKFIQMGMTRARRYANHKGGRKYDKDGRQLDKWSGDDAGGKRKEKEEASEIFKAYWRRCVECEKYARLKKDWAQAKKEYLETRRSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQV2</accession>
    <name>A0A0D2BQV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233730.1">
        <property type="nucleotide sequence ID" value="XM_016383027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQV2"/>
    <dbReference type="STRING" id="91928.A0A0D2BQV2"/>
    <dbReference type="GeneID" id="27335785"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08702"/>
    <dbReference type="HOGENOM" id="CLU_018204_3_4_1"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000037">
        <property type="entry name" value="Similar to acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF34">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="57"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="159"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="271"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50447" checksum="015AF87B682D856B" modified="2015-04-29" version="1">MNFELPSEVQSYLSRLDDFITSKILPLQHTGTNNRFFDHRREASRTQWDNGGLPTDDWEDLLREARKLADEAGFYRFAFPKEYGGVGSTSQNLYMSAIRYHLASHPVFGGGVSLANDLQNEHSVVGNNPIVIMLHHYGTPEQQQTFIPASVRGEFRATFGLTEIHHGSDATHMDTTATPITLPSGEAGYSINGNKKWQTGMHNATHCLIFARTSGKAGSPKGITAFIVPRDTPGVTVASYEWTLNMPTDHATVLLEDVKVPASAILGPVDNGLAIAQTFTHENRIRQASSSCGAARYCIDRSVEYANSRKVFGKPLSSHQAIQWPLVELATQAEMLRLLILRTAVEMDQVTAACKASGKAPWVAIEKQLGHKIGMCNYYANRLATEAADRAIQVHGGVGYSRHYPFEHIWRHFRRYRITEGSEEVQIRKVAAYLFGYKSTGESPPDLKKPETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRD7</accession>
    <name>A0A0D2BRD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241839.1">
        <property type="nucleotide sequence ID" value="XM_016376563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRD7"/>
    <dbReference type="STRING" id="91928.A0A0D2BRD7"/>
    <dbReference type="GeneID" id="27329286"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02203"/>
    <dbReference type="HOGENOM" id="CLU_044876_1_0_1"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="310" mass="33443" checksum="760FB88E24AF94DA" modified="2015-04-29" version="1">MSTPAIQGRRIAIIGASGQLGKPTVQALLGLGAHTVTAIQRLDATSTFPAAVEVKKGNLDDENFLAAALQGQDAVVLMPPLPQLIQIQEPAIRAAAKARVPYIFPSEFGPDPFAGQLLEENELLVTKKRVRDLVEELGVSNWVSVVVGPWLEFGLSTGLWGVDAKARKATLWKGAEGKASVATVAHTAEALAATLSLPEADLAKYKNNAVYAASFSLTQREILDAVQRADGTTDADWDIQIRDLNDVARDYEEKIKAGDSVAPYEKFYVTHFIEGHGGDFSDKIDATELEKLGRLGLHTEDLQEVVKAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRF7</accession>
    <name>A0A0D2BRF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241869.1">
        <property type="nucleotide sequence ID" value="XM_016376593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRF7"/>
    <dbReference type="STRING" id="91928.A0A0D2BRF7"/>
    <dbReference type="GeneID" id="27329316"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02233"/>
    <dbReference type="HOGENOM" id="CLU_036005_1_0_1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="48"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="370" mass="41292" checksum="F0E20670D097C13C" modified="2015-04-29" version="1">MAPPAADIDLASNQASTIPVPVNKGPQSSLLKEPLKYSGSLDKYKSFDVTNVIGREFPELQLSGILHDDNQIRDLAITVSQRGVVFFRNQNLNIDDQKILGQKLGELTGKPATSKLHRHALSNSKRGIAVDENGKLDDEVSVISSEQNRKFYKDRYPAESKKLASEGWHADITFERIPSDYAILKIISKPEDAGGDTLWASGYELYDRLSPAIQKLAESLTATHYQPAFNEVAKKFGEELIDQDRGAPENTGLDFTASHPVVRTNPVTGWKSLFGAGHQVAAGWIDNVTPRESEILKDYFLQLITDNHDLQVRFRWNENDLAIWDNRSVFHTATNDYTGKRQGNRVVSLGEKPYFDPNSVSRREALRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRP0</accession>
    <name>A0A0D2BRP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241271.1">
        <property type="nucleotide sequence ID" value="XM_016375995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRP0"/>
    <dbReference type="STRING" id="91928.A0A0D2BRP0"/>
    <dbReference type="GeneID" id="27328717"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01634"/>
    <dbReference type="HOGENOM" id="CLU_020695_9_1_1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="438"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="6">
        <location>
            <begin position="531"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="535"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="680" mass="75985" checksum="7164EC0B13D40916" modified="2015-04-29" version="1">MDVKPHRPIRIRVNNDENLPPVGHNTKTIHQRNKSSPALTGLPPTQGLAAGAKRKVFGDVSNTATGVKPSKDDLALQNKPILQPTIKPLYERKSTSLLRPAQRPLSVSGLKTFFSTAGNNAASDNAVTVPAEGSGLHSQAPGGKKTLTKRHTTIFKDNRLVTVQETESISVQSNTPDDAAQGKDAVEITRLDRQPLPLPLPSTSQTVVEPVKEVSEPRSEISLPGIDEVSLEPAVSRAVNNDSYVREAVTTISELAGLPVNSQHELHTTSTVLPPLSLNTSAQASTKSESQQIAVAKLVNPVDAAPPLPSHNNYLIGTTEQEEYWEEEDEENYEEEGYVTARSFRSRGDNTTGGATAVLFPQVNQRIRKELAQAKQLVEATRSPEELEDESFDTSMVAEYGDEIFDYMKSLELKMLPNAHYMDNQHEIQWSMRSVLMDWLVQVHLRFNLLPETLFLTVNYIDRFLSCKVVSLAKLQLVGATAIFIAAKYEEINCPSVQEIVYMVDGGYTVDEILKAERFMLTMLQFELGWPGPMSFLRRISKADDYDLETRTLAKYFLEVTLMDERFIGSPPSFTAAASHCLARVMLRKGSWTAHHVYYSGYTYSQLEPLVSLLLECCDNPRKHHSAVFNKYCDKRYKRASAFVETEIQRGFQLPDYSTSVFLSQPPTLPYYDSISYYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSZ7</accession>
    <name>A0A0D2BSZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234610.1">
        <property type="nucleotide sequence ID" value="XM_016381508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSZ7"/>
    <dbReference type="STRING" id="91928.A0A0D2BSZ7"/>
    <dbReference type="GeneID" id="27334259"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07176"/>
    <dbReference type="HOGENOM" id="CLU_1532562_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012745889" evidence="1">
        <location>
            <begin position="16"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="175" mass="18091" checksum="62D9E0BBC8A753BC" modified="2015-04-29" version="1">MKSFTTALLIAGAYAAAVPGFPGGAGGSWGDWNQWASASCEPKTTTEYSTAWSTAWSTAWSTAYSTVTTVQVSTATVPATIPVTQSSTVTVPTTIVTTVPTTVPVTVPVTVPVTQFATVTVPTTVVKPTTIYNTLTTVSVSTATVPTTVTVPTTVYSTVTASQGWGDWKGWNTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BT53</accession>
    <name>A0A0D2BT53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_02165</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241801.1">
        <property type="nucleotide sequence ID" value="XM_016376525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BT53"/>
    <dbReference type="STRING" id="91928.A0A0D2BT53"/>
    <dbReference type="GeneID" id="27329248"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02165"/>
    <dbReference type="HOGENOM" id="CLU_011752_0_0_1"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="290"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="163"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="507"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW21585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="934" mass="103464" checksum="C0B006AFBA986E86" modified="2015-04-29" version="1">MSQSYFPDQGSSSRSPQDEDASDHANFDHEMDSPAPIRPPNYRPEYMTVGSGGQSSHAAALMEQLERDSGYGSMPGDVQQQGGEMRTWENELLRDRPTPAHTPQVDGQPAKMSETEKRALASHVHQLYYNQNRVALAKAISQTVELLKQLQEMNTQWPAHYPSVQRSEDDRHPQRPALTQAQSTRDESDLSREVFLKNRPGALRRAGTSIGEDTTAESSSQAHQRRTPEPRLITPQIAQEFSILKLDLKVGALSQTELVHSLEKKSIASLLDGKISQSVRHLLALRDRIEDTSSKVLVTGDLNAGKSTFCNALLRRKILPEDQQPCTSIFCEVLDAKENGGHEEVHAVHKDSIYNRNDESTYDAYSLQELEKIVVDNDRYMQCKVYVRDVRTIDQSLLNNGVVDIALIDAPGLNSDSVKTTAVFARQEEIDVVVFVVSAANHFTLSAKEFIWQAAHEKAYIFMVVNGFDNIRDKERCQKMILDQLAKLSPQTFKEAQELVHFVSSNAIPTQPSLPPSGDDGGASGSGPSHPPDGDDGDDDSGKGKGKDKEKVQDFEVLEGALRRFVLEKRARSKLAPAKTYLMNCLGDMNVLATVNRDVAQAELERVSKALDEIEPEFEDKQKHRSIISEQIEKDIDSTASNVYNHTRATLSSTIANVGKENHGIEYPGLWSAFQYAEDLRIAMLGQISAAVTNCESYGRAKTVEGVSMIKSLGLLHVGESYENLSFQADKMFQRRKDALVRSVDTDIEIWDFFDIAGLWERQEKTVGTGLALTVMGTVGTRAVGGVGWVDGAFGAAKILGSQNLRRLFVPGVVAAAVLTVAYVLSNIPQTLPPRLASKLSATLAEMDYTHSNANRIAAEVRRVLRYPAQRLTTDLTQGVEELRQKKEDVTKIKRESEVARKYFGNLVRDSSETRRRVSSIDLEGLPGPVGAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BYT7</accession>
    <name>A0A0D2BYT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Maintenance of telomere capping protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_06523</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MTC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236685.1">
        <property type="nucleotide sequence ID" value="XM_016380858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BYT7"/>
    <dbReference type="STRING" id="91928.A0A0D2BYT7"/>
    <dbReference type="GeneID" id="27333606"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06523"/>
    <dbReference type="HOGENOM" id="CLU_033723_0_0_1"/>
    <dbReference type="OrthoDB" id="5573651at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051008">
        <property type="entry name" value="Telomere_Capping_Maintenance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057530">
        <property type="entry name" value="TIM-barrel_MTC6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518:SF2">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518">
        <property type="entry name" value="MAINTENANCE OF TELOMOERE CAPPING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25506">
        <property type="entry name" value="TIM-barrel_MTC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="MTC6 partial TIM-barrel" evidence="12">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW16469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="634" mass="69281" checksum="0B2C6874D030CE5F" modified="2015-04-29" version="1">MSLKYNPSSSAVSDAHWTTVFLSTRDASAEVPIDFITRPGVYLTQACFPNGVYDDIPAQTCLSDLLASGFGRIVIDLYWDNINRQFNLCPVELPPLAGNSTAGYSVDFSALSSITSTTSSALNPTEPLSAPTIDPLVKRQSGVNNTTTSISATPATTSVTSAAPIPTTTGVAGTELLELGPFKCSLDLNLDSIMSLYNDYFDQTSDTISARLHYITFNLHAASPFTAPSESANTPMQARLPRGDSLIGSQFEGNLPQDLYTPDKLQDDRDNLDKSWLEGNTDSNYFIVDHRGDDSITTDGWPGESSILLASHRRLLLSWGEVDPQMRAYDFQNDSGNVFPSDYLAIEHKVTINDEGDITSGCFYDPGVTTIGAQNSSGAYTTINNIIPSQTLQHMVQNLTACGISPMLNVTLGNLTVQNDLDAYQQFARSTVFGWASGEPRTGSQTQTTQKRANDDDEDYACAVMDSTSGYMGRWRVEPCQKQHRAACRIAEEPFAWRLSTYEVPFQSAPDACPESTTFSLPRTGLENTYLYRKIMNDSSSGGDESILSGVWIDFNSLDQTNCWVSGGPNASCPYNGPDDSEDQREVLIPTIAALIVLILTVLTLLVKCNENRRNSRTRSRRGDDGWEYEGVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0E4</accession>
    <name>A0A0D2C0E4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_04265</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237290.1">
        <property type="nucleotide sequence ID" value="XM_016378613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0E4"/>
    <dbReference type="STRING" id="91928.A0A0D2C0E4"/>
    <dbReference type="GeneID" id="27331348"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04265"/>
    <dbReference type="HOGENOM" id="CLU_005912_5_2_1"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="49"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="485"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="570"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW17074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="699" mass="76183" checksum="350BF57B95E502EB" modified="2015-04-29" version="1">MASSLVGASLHFLRRQAEELDPDDAAPEAGQKEIFSSWALFILIMLLIAALFTSYILQQKRIQAVHETVISIFAGMVVGLVIRITPGTAIQDTVSFDYQFFFNLLLPPIILASGYELHQANFFRNIGTILTFAFAGTFISAVSLGLILWLWTRIPFDGLTITWVEAISVGATLSATDPVTILAIFNLYKVEPKLYTVIFGESILNDAIAIVLFETAQRYREGASGNLSVISLFEAIGIFLLVFFTSLLIGVIVGVGTALTLKYTLVRRFPKIESCLVVLIAYASYFFSNGVHMSGIVSLLFCGITLKHYAYYNMSRRTQLTTKFIFQILAQLSENFIFIYLGLTLFTETDLVFKPLFILVAVMGICAARWLAVFPLSKAINYIIRLRAKKRGRDVADELPWHYQAMLFWAGLRGAVGVALAAGLQGNEGPALRATVLVVVVLTVIIFGGTTARMLEILGIRTGVVEEIDSDDEFDIETANGGTYYKRSGTGFGHHPRPTNIGLDYIENSTNRRSGHANGSASHPRSDRGYSSSNGASPPFDKPKRAGSNRKNSNISQREREITAQQGKLLDHHGGSTSDDDEDAIDLDLPPAAPRRKPSPLAGFSGNPYAPPPRTRSAPNIVLNDGEHGTDGDMGVAGSTTGGTSTPLSGPLGSNSIRNLLRGATADHTAWFRQLDEDFIKPHLLLDQHQGQGKGPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0F4</accession>
    <name>A0A0D2C0F4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237310.1">
        <property type="nucleotide sequence ID" value="XM_016378633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0F4"/>
    <dbReference type="STRING" id="91928.A0A0D2C0F4"/>
    <dbReference type="GeneID" id="27331368"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04285"/>
    <dbReference type="HOGENOM" id="CLU_103823_1_0_1"/>
    <dbReference type="OrthoDB" id="5598843at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="148" mass="15399" checksum="7EEA8A60DB878941" modified="2015-04-29" version="1">MTKFRNRGGRRGPESRGPNQQQRPSGGSRDGTPGATQGRRGGRGGGSTLNRSSDGMQNGSSSHTAASTPSDDHVPMTGYNSGAVEAMLKQGYDARAPLYKPEAKTPATKPESPWGAKPGAMVGGKDFWLELRKQVAALQQSGGTSRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0R2</accession>
    <name>A0A0D2C0R2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237485.1">
        <property type="nucleotide sequence ID" value="XM_016378808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0R2"/>
    <dbReference type="GeneID" id="27331543"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04460"/>
    <dbReference type="HOGENOM" id="CLU_032922_0_0_1"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="589" mass="66017" checksum="C170A966C6563F77" modified="2015-04-29" version="1">MFLSLTKRLYRLPSSPFSTIITFVLLLCIYVFVSTTRSLLTSNGYLSSLRCCSEFTTRSTVLHSTLIDAGHPHMQFVGRWTSSADGRRRDAAFPGSSVEIILTNTRSISLSLNNAVSSSQPPVGDGVHENLDHSNLRPITSDHKASEPVNLVVQLNNTYTTFTNARAIVPVASDLDPRTRYSLKVRHMGGPNATEGVLEFHGIWVENVTHDTKIQSHRTKDVSSRQRTGAAQTVQPAKKKPAIEILTSETEGFSISKEESLEDTILTRISTWYEQLGSAHGIDTITMSTKALGLLPSSHTRTTTISHLFFRSGPAGTHLFGRPWTFATYRPSILILQLGLTDFTTFFSDPTNRDRHARDQFVNDFVNAYVKFLKTIRRTAYPFDPASLPADRRNRIVDPTYLSNSAPSTLPIFLVAPFSASTHFVTKDTRLERIINDALSRVAQAVRADGDISTFWIDTTGWLDPKRDFDTHGIKNQLNQLNQNDAHDVDGESQMDHQNETHLPTLSHAAHLKVSTLLWDHVCPYIISDNDATTTTANGKTECPFDRRSTYMGNVYLPQDVEVERTVLERKINRIKQQFKITGPKMLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C2F2</accession>
    <name>A0A0D2C2F2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238040.1">
        <property type="nucleotide sequence ID" value="XM_016379363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C2F2"/>
    <dbReference type="STRING" id="91928.A0A0D2C2F2"/>
    <dbReference type="GeneID" id="27332102"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05019"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="94"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="243"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="558" mass="61737" checksum="BE7E59C90CD2945F" modified="2015-04-29" version="1">MVARPLPIIQPKAVPLGTPEFEEKRAALLRTLEESIPREYYLPQEIFDKKPTDVSTIPSTCGLLSSEEIQITEQYDAVSLAEAIATRKFTAVAVAKAFCKRAAIAHQLTCCLTQFFEPEALERAAQLDEYLEKNGKTIGPLHGVPVSIKEHMPTAGHYSSAGEFSTLVKDDKDALLIQIVREAGAVFYCKTNQPQGIMHLETTSFYGRTLNPYNINLSCGGSTGGEAALIALKGSVLGIGTDIGGSIRGPSAFCGIYGFKPTSYTLPMTGMLHAPFPAELNILCSIGPMCRTMRDMEFFTNVILDAKPYLEDPRLIPIPWTGLKTEVPKKLKIGIISHDGFIDPQPPVKRAVAWAKEQLSDPKYADLFEIKDFTPYDAAGAWSKIRRMYWPDAAAGIREAIACTGEPELSLSSWIYKDAEPEGMQTATAVSYMRHERDNYRMAFAKAWNKQDVDVVIGPCFVGPASMHDTAFYWTYTSLYNFVDYPGVVFPTPIKAEAGEQYASDYKPLSDACQHVKQLWEEGNFEGAPINLQINARKYHDNQLFGALTLLKDALQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3M5</accession>
    <name>A0A0D2C3M5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238460.1">
        <property type="nucleotide sequence ID" value="XM_016376890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3M5"/>
    <dbReference type="STRING" id="91928.A0A0D2C3M5"/>
    <dbReference type="ESTHER" id="9euro-a0a0d2c3m5">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="27329615"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02532"/>
    <dbReference type="HOGENOM" id="CLU_006586_15_0_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112411" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="27"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="521" mass="56860" checksum="5EB1D5714E765D02" modified="2015-04-29" version="1">MPSRYILSWLLTCFLGIAFGSRCGSSAPTVKIDAGMVVGTTTTVPGTTATVSEFLGVPFAASPTRFAPPTRPVPWSTPLQATAYGPACPQQFNYPEELREITMAWFNTPPPSAGESEDCLNLNIYVPGTENTNKAVMVWIYGGALEYGWNSFHLYDGASFAANQDVIVVTINYRTNSKYMFWDMRNLGFLDQRFALDWVQRNIAAFGGDPRKVTIFGQSAGGRSVDVLLTSMPHNPPFRAAIMESGVANYNFPKGDLSEPWNTTVQALNCTTSIDILSCMRRVDLATLMNTIEQLGLGFEYTLDNVTAVYRSETARTTGDIARVPVLVGTVANDGLLFVLGENDTQAYLEEAIPNQPDLYQTLLGAYPIGSPGIGSPQDQIAAIETEVRFQCPSAIVAQDSRNRGIPSWRYYYNATFENLELFPGSEVYHSSEVGMVFGTYPVASATALEAQTSKYMQGAWAAFAKNPMNGPGWKQVPNVAALGSPGKAIQVDVSPATIDQRCALYTRYYTELGTIAPRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C4E5</accession>
    <name>A0A0D2C4E5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Conidiophore development protein hymA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238675.1">
        <property type="nucleotide sequence ID" value="XM_016377105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C4E5"/>
    <dbReference type="STRING" id="91928.A0A0D2C4E5"/>
    <dbReference type="GeneID" id="27329830"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02747"/>
    <dbReference type="HOGENOM" id="CLU_035755_0_0_1"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="44526" checksum="B73BCDA72D8A02C7" modified="2015-04-29" version="1">MAFLFGSRGRQKHPAEIAKGLKELLGKLGEGSKGGNGNGNGASGKVEEEVGKHMNQMKLIVQGTPEVECSPDQVHQLVTCIIQEDILYELARSIRLLPFEARKDAQIIFSHILRWRPNGAPPTTEPSAISYLVVQRPEIIVELCRGYEHPQAAMACGTILRQALQYDTIAAVILYDESQPNVEGERAVQLKEVDVTKKQSGNGVFWKFFGWINRGSFEVSADAFTTFRELLTKHKSIVSQYLATNYDLFFKTHYNPTLLLSQSYVTKRQSIKLLGELLLDRANYVIMTQYVASGDNLKLTMNLLKDDRKMVQYEAFHVFKVFVANPNKSDDVRRILVKNRGRLLRFLPTFLEGRTDDDQFLDEKSFLLRQIETLPEEGTDQPAVNGGDGSGLRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C4L7</accession>
    <name>A0A0D2C4L7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238720.1">
        <property type="nucleotide sequence ID" value="XM_016377150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C4L7"/>
    <dbReference type="STRING" id="91928.A0A0D2C4L7"/>
    <dbReference type="GeneID" id="27329875"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02792"/>
    <dbReference type="HOGENOM" id="CLU_091428_0_0_1"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="1">
        <location>
            <begin position="23"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="199" mass="21446" checksum="18E02BB397FEE205" modified="2015-04-29" version="1">MASGQPTDPYKAKNKDEPGVETKIEQLNNFIQSQKYGMMTTRIAESGLLVSRCMALAAQESGGVDLLFHTNTESGKTHDLESDSHINISFCSANGSWASISGTAAVITDRAVVKKYYTPALKTWLGDLGDGTHDGSENDPRIGVIKVKAVTATYAVSQGTFLGRGVEMVKGAITGEAAQVNALREIDEEEIKQWRLSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C5C8</accession>
    <name>A0A0D2C5C8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_03088</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239015.1">
        <property type="nucleotide sequence ID" value="XM_016377445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C5C8"/>
    <dbReference type="STRING" id="91928.A0A0D2C5C8"/>
    <dbReference type="GeneID" id="27330171"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03088"/>
    <dbReference type="HOGENOM" id="CLU_025879_0_0_1"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254973" description="Protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="46"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW18799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="365" mass="41124" checksum="2F640B676AF2401F" modified="2015-04-29" version="1">MSWHLQHLSRYIFLLCSLRVTCSELPSTVFPSLSRYFVLTTQLQQPWTPPCLSLAEEWATAESELTQPLVSVDCTAEPDLCAEHDVRSYPAIRLFHGRLAGDTNKTSSIRYRGPRKAPSIVPFVKRAALPPISTVTAHNLTDLTSIDSVTFVAYLDDDDGNVMRTRYARVARAFHDRFVFGVAQDDQLAEQEGIDTSSIVAYKSDVGDRDVFVLDATTKRADIEKFVLEASTPLIGELTRRNERTYMIGYKLLAYMFVSNDRDRASLRRSLHPVAKQFKDYVNFVTVDSHEYGHMAPGLGLNLSGDGGESPAFTVYSAWKDQVFPYPETQHVTAQQIEAFMLQILHGDRAPWDPRNARSNGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAD1</accession>
    <name>A0A0D2CAD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PV08_01079</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240720.1">
        <property type="nucleotide sequence ID" value="XM_016375444.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2CAD1"/>
    <dbReference type="GeneID" id="27328162"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01079"/>
    <dbReference type="HOGENOM" id="CLU_000315_26_0_1"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000006">
        <property type="entry name" value="Putative DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001269">
        <property type="entry name" value="SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="20">
        <location>
            <begin position="549"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="805"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1378"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="358"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="675"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1563"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="619"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="374"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1563"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1591"/>
            <end position="1610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KIW20504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1666" mass="187915" checksum="716E3CE5C4C60DA5" modified="2015-04-29" version="1">MSGSTPFTARSPTQSNQYPPYSPTHPNRPFFGHEPFQIPPPQHLMQTPPPFQPASLAQSPHHNRPPALASPLPAPNGLPPPPVPVGNGPPQYPQGLTSSPPYPLQRTYSGHLIPPPPGMASQYDAPSHGHPAGPALQPSPLREPQHLSNGRPAETYVAESRPQSKDKPDRASNPMSFASILGPSNNEPSPKPVETKPPRLSTPPPMPATPTIVTPEKVVKQQEVEPHKLLTNGEVKEKRKLDTLPVAKKHVAPSKPRTALTEIEADKILKAMNMIDEGPQSDADEEGFYELKERYKQRGKKRAAEIEEAELRKRKRRRDYLLDSFIKTFESHAIEAAQRFRAEVEPLAAKEIADKDIATEKERKKDMQRKRRREQQIRNEREKLEELEERARNAEDQEEAQKYLKQAEKSQARIRQTAELLEGGPPAEDLEVSAPAPNYEGGVTSSFQIGSPEPSEAPPKKRAKKEPGAPSARLKKSKEKKQAEKDAAEAAYLAMQQDPDKEATTAPKEDTPEKEREEEEAAAAAAAAAAAQQGINYDSKGYNQIYEQIWRDLARKDIPKVYRIKQVSLSTKQENMRKTAILASKQARKWQERTNKSMKDTQARAKRVMREMMSFWKRNEREERDLRRMAERKEIEDAKKAEADREANRQKRKLNFLISQTEIYSHFISRKIKTDEIESSTNDPSISGSGEKAGTSDAKENRTMDDMTLSHEHGNHKMTNFEDLDFDAEDDSDLKRAAMANAASALQDAQDKARNFNGDDPMSAFDSSDMNFTNPTMAGDVQVSQPKMLQAQLKEYQLKGLNWLVNLYEQGINGILADEMGLGKTVQSISVMGYLAEQHNVWGPFLVIAPASTLHNWQQEITRFVPAIKVLPYWGNAKDRKVLRKFWDRKHVTYTKDSEFHVLVTSYQLVVQDAQYFQKIRWQYMILDEAQAIKSSSSSRWKTLLAFQCRNRLLLTGTPIQNNMQELWALLHFIMPTLFDSHDEFSDWFSKDIESHAQSNTKLNQDQLKRLHMILKPFMLRRVKAHVQKELGDKVEKDVFCDLTYRQRAYYANLRSKISIMDLIEKATLGDDQDTATLMNLVMQFRKVCNHPDLFERADTTSPYSMSTFAETASFLREGSFVQLAYSVRNPIQYDLPRVLCNDVGRLDIAGPNNARAGFCRAGFKSDGIGGLMRIWSPEYMNKSAENDGAFSFLRFVDTSPAEAVHAADHGVLERAIKLVKKPKRALPIFDDQEAQPPAHAMFNIVENSPRQPLAELDPNSNLAQLCNISRRSLEDDGYSVLEPAATPAALAPPIEVSAFDQSSLTERQLTMFNMGVRSTLYPLEENIEVKLLEQDVAPENFPLSDLMPKPQSQKARYTHISIPSMRRFVTDSGKLAKLDSLLRELKNGGHRVLLYFQMTRMIDLMEEYLTYRNYKFVRLDGSTKLEDRRDTVHDFQTRPEIFIFLLSTRAGGLGINLTSADTVIFYDSDWNPTIDSQAMDRAHRLGQTKQVTVYRLITRGTIEERIRKRAMQKEEVQRVVITGGDGAGVDFNTRDRRENRTKDIAMWLADDDQAALIEQKEKENAEKPEEDTKKKSKKAQAAAAARKRKAEMSLDDMYHEGEGHFDDASAKPSGAATPVSSAETPGPKKGLGSRGGKGISKKAKTAKQRLAIIDAEGDLGMGGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCB1</accession>
    <name>A0A0D2CCB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241340.1">
        <property type="nucleotide sequence ID" value="XM_016376064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCB1"/>
    <dbReference type="GeneID" id="27328787"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01704"/>
    <dbReference type="HOGENOM" id="CLU_1835207_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="140" mass="15560" checksum="94B8E79F2701443B" modified="2015-04-29" version="1">MRCGKRGYEDAVSDVYQIFGCDETDEDSLKAAKQPSLPRPPQYNAAAQDPIADTVYRDQVIGNLWERCKAEQDGTFGALHAFSCYWCGWFGYEIPEDEVPNMNAGGNAVCKKEMCETLIPPSNRQEGNSKDATSQPDIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y6V0</accession>
    <name>A0A0D1Y6V0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230817.1">
        <property type="nucleotide sequence ID" value="XM_016385873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y6V0"/>
    <dbReference type="GeneID" id="27338648"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11565"/>
    <dbReference type="HOGENOM" id="CLU_1378144_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="198" mass="22166" checksum="EC6395937D1DD54D" modified="2015-04-29" version="1">MALQAQVPIPGPGLELNIHLPLSPPARKSIINDCWNAGLNDRDFARQYKNFQPYFENYESLCQSCSPDDLGQLRHSDLLGAFNRIVTQSRNTCIGELKALLLTFPAPFSQPQDADEFVRMWIDTTAECLLLLDVHSWAGNQTLKEFLEVEFATQKTSSGPYAPFSKVPCEEPRENLRHADTLDKSSVEASGPGRERKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y920</accession>
    <name>A0A0D1Y920_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_10766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231682.1">
        <property type="nucleotide sequence ID" value="XM_016385080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y920"/>
    <dbReference type="STRING" id="91928.A0A0D1Y920"/>
    <dbReference type="GeneID" id="27337849"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10766"/>
    <dbReference type="HOGENOM" id="CLU_011099_3_2_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="243"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="659" mass="72565" checksum="1DAAAFCAB16DF13F" modified="2015-04-29" version="1">MEFLLETSALRQEGIAAPSTRSPRSSALSHQPAINAAPVAAPSSNPLLSNDKPTFAGHRAQQVAEAVLPSSTTSPEQSLANNGISILPTSAEDIPLVHFHEGKVQCLRDSMLRSKPSRLEFISMLPKTEALLLVESFIEDVNKVFPLFHVQSLKFMCRHKYPVDADSVEPAWWACLNAIIAMEIQLKISNSTSRAVAEFSWSFFKNAFFVLTELITDSPSILAVQAVLVMATFMSGTTDLQTSTFLTSSAIRMMQTIGLDKEDLGNRLSAIEKEQRRRIFWIAFLLDGATSLNLGLPPVLDFENVRINLPTEDSPDGLGTLFNSDGTGSVNIFRLRVELAIIRSKIYKRLFSQDVTGVTGHYAQNQVSELQYELRVWKEKIPAEIQLDHASQTGGETRELPVVMLQFEFHHCMDLINRTATARHSSQELLRRGAFCTDAARKTLRLLDFVGCPPFSDLWRALPYPLCATITLLAEVLARPAGTQAAADVSLIGSFLRFLKNIQQKEGYDITRFVGGCAVLNDAAKAAIARTQAEGCIQTEIEVRGDATQSPVDPVSDPTIQAKLTERLLSWLQKFPSYMHLAHGLMGNMPRLTYAASLVLSDIFRGFDGNGAPFQSFASETLMPSTYGLGSATSQVPTSAVHPHADTCENTTQWELLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDY1</accession>
    <name>A0A0D1YDY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233497.1">
        <property type="nucleotide sequence ID" value="XM_016382794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDY1"/>
    <dbReference type="STRING" id="91928.A0A0D1YDY1"/>
    <dbReference type="GeneID" id="27335552"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08469"/>
    <dbReference type="HOGENOM" id="CLU_002639_3_1_1"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="178"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="710" mass="78933" checksum="90DE21D5F187B88E" modified="2015-04-29" version="1">MSDSVESESEAPDTNDICIHFQRGAVSAASAGYRVSQLQHNATTCDFCAVMLEGLSTVLGASLDPDYCVSFKLKHQANIPPRLTYEKQDDFSTQQRFEISPVSEGSNLPRPLSKVEPFLDIAPEASSEACVKRIQFWLDNCQSVHGFCAESLESTLPRRVLEVDTLVLHETQGEKGKYIALSHCWGSGDSLKTEKSSIGQRKQGIQWDELPQTFQDAITISKALGVQYLWIDSLCIVQDDQNDWEVESGKMDQIYKNSYITIAASVAKGDHEGFLRPRTHYLTSIARVELSNGVEESFKIRPLPAKHYRRDVGPRNRSWRHNMTVPGAQPQPLETRAWCFQERLVSSRLVSFCEAEMEWDYPTLSRCECGTRLLAHDECFNRVLGGMEPVPGKSSIRSLYQSLLCIAAIFADDPKPEHRDALNDLVRHHWHNLLIPSYTLLALTRPSDRLPALSAIASELKEILKDDYLCGLWRQGLTQGITWVAGSFGTDGPQPGVLPQVYRAPSWSWASTEGPVDGDRAFNSSVHYLFRITEARCTPMAGSILGPVTDGSLTIEGDVIRAELKVPAVCHGDDEHKVEYRISTPDGKPLSSSFYPDTPLVGMETETASGTVRRSGRRLSAARDSIDAPVLCLVLAGHRTHRLPTYMRRRLQEREGEEETIEGGGVFDSATLMVLGLPLSPADFYQRLGLARCSWSDIVDVKVGMTIEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YFL4</accession>
    <name>A0A0D1YFL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BUB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234072.1">
        <property type="nucleotide sequence ID" value="XM_016380970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YFL4"/>
    <dbReference type="STRING" id="91928.A0A0D1YFL4"/>
    <dbReference type="GeneID" id="27333719"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06636"/>
    <dbReference type="HOGENOM" id="CLU_029367_3_0_1"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000035">
        <property type="entry name" value="Cell cycle arrest protein BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="7">
        <location>
            <begin position="177"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW13856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="443" mass="48661" checksum="24A7738440B599B8" modified="2015-04-29" version="1">MATSSVSPLKIPARGAFLSPPDPTAAALPESPEKGNAFPSAFDQKPRSLRRLQSHNQLSSANMGTQYSNLKPRSAVPTRPSREQLSQPNTTIATNSSSNPSSRTRANSDALLPYVPQKPRKAGVTSPPSSNHIANHARKSSLEMTLRDGPPPGTTATTALSLLRHSILTSGVTATKEGMSDYRVYLWLTLLNVAPLPTDTYLGLIHRSRSPAYEKISNDVFRTLATDTLFKRRVTDASLTRLLNATAWRIHDEQNSDPPSDFAQRYPQATYLQGINVLSAPLLYASRSEAQAYALLSCLLTEHIPTYLSPTMSGVHRGLELIDRILAYINPSLSAFLLSKSLPAKIYAFPSVLTLCACTPPLPEVLKLWDFLFAFGVHLNVICVVAQLLLLKDKLMNEPSPAKMLRSFPNLNADEVIKMTVLIVRELPEDLYRDIVTHGREVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIK4</accession>
    <name>A0A0D1YIK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_07556</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234987.1">
        <property type="nucleotide sequence ID" value="XM_016381885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIK4"/>
    <dbReference type="STRING" id="91928.A0A0D1YIK4"/>
    <dbReference type="GeneID" id="27334639"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07556"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="108"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="404"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW14771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="468" mass="52548" checksum="9D7F141B7451A0DC" modified="2015-04-29" version="1">MASKTSKWANDDDEEAAAALALRKKEKEERKRLKEEKARKAAEATTTHADESASHTPSGDDQRPPKRQRTSESQNNGTGEGKDKDEEGAHLLHFPSRAIQPCRHVSQYETLNSIEEGSYGFVSRARKKSSGAIVALKRLKMHNEATEGFPVTGLREIQTLQSCRHDHVVKLLEVVMGDSLRDVYLVMEFLEHDLKTLLEDMAEPFLPSETKQLMLQLVSATEYLHSNWIMHRDLKTSNLLLNNRGEIKLADFGMARYAGHPRPQRLTQLVVTLWYRAPELLLGAEEYDFEIDIWSVGCIFAEFLTREPLFQGNTEVDQLSRIFALLGTPTNETWPGFRSLPNAKALHPILSKSSSSSSSSSLSVSKFPYLTNSGLRLLASMLSMDPSGRPSATEILSHPYFKEDPRPKAKEMFPTFPSKAGQEKRRRRATPQAPVRGDAPKLDEREFEGIFAGRADEERGAGFALRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YK16</accession>
    <name>A0A0D1YK16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235542.1">
        <property type="nucleotide sequence ID" value="XM_016379715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YK16"/>
    <dbReference type="STRING" id="91928.A0A0D1YK16"/>
    <dbReference type="GeneID" id="27332454"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05371"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006393">
        <property type="entry name" value="PRK08642.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27209" checksum="98882AC812DA01E6" modified="2015-04-29" version="1">MRLEEQVVLVTGSSKGVGLAIVKAFRAQGAQVVLNYHSSNPETVAGIAQEIGAFPFRADVTDPDQINALFVAAETHFDKPITTVVNNAIAGNFEFNGDVGRRKVHEIRWSDFDVQLRGFLRGTLNTTQAALPGFEKLGCGRIINIGTNLFHNPVVPYHDYTAAKGALLAFTRTCAADLGPKGVSVNMVSGGLLETTDASASTPKEVFEQIRAVTPLRRVTKPEDLAGAVLFFASPWADAITGQEVIVDGGLVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YL57</accession>
    <name>A0A0D1YL57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235997.1">
        <property type="nucleotide sequence ID" value="XM_016380170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YL57"/>
    <dbReference type="GeneID" id="27332914"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05831"/>
    <dbReference type="HOGENOM" id="CLU_020027_0_4_1"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027279">
        <property type="entry name" value="D_amino_pept/lipop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012856">
        <property type="entry name" value="DAP_B_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009622">
        <property type="entry name" value="PRK13128.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07930">
        <property type="entry name" value="DAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50886">
        <property type="entry name" value="D-aminopeptidase, middle and C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="20"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="D-aminopeptidase" evidence="4">
        <location>
            <begin position="358"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="58761" checksum="504DC92FEC6F78AC" modified="2015-04-29" version="1">MTATAASISEILADVPSQFRGPGGAVAVLKDGELVGQQLWGYGDLHSRVAMAADMVVPICSISKQMVCGLLTDLERNPTPAMKARGDEPAKQLSDQLEKLLNPNLLKDRGLTLRHLANNQSGIRDYWALTVLWGAKPEGHFSIADDGPQMLARMKSFHFKPGTEYSYANTNFFIIGGCIEQVTGQPLGELLSERIFAPAGMKTARLCAHAAEHPPPCVGYEGNEALGFYPGVNCIEWAADAGIVASLTDMIAYEKFVDRSSHGDLQSWYTVNSEQQKYNDGSPAEYGFGLGRSLVGGVLNIGHGGAIRGYRLNRSYCPERRISIMVLLNQEHGDPVGLSDYILKRMLGVTEAKHEIVSAGPDWPGTYLDPDTGLAIVVSKASAPGQLSFTYHLKPEKVRVIEAYKARSDGIVANLDGDSLHVHLPHDNRTLHAKRVANKKPAADYSELQGDYRCDEIDSVFHCSGAGDMLYGMFDGFLGQGPVHLMRSLGEDVWALACPRAMDSTPPGDWTVIVRRGDDGKLTGLTIGCWLARNLEFTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNC0</accession>
    <name>A0A0D1YNC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236777.1">
        <property type="nucleotide sequence ID" value="XM_016378100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNC0"/>
    <dbReference type="STRING" id="91928.A0A0D1YNC0"/>
    <dbReference type="GeneID" id="27330832"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03749"/>
    <dbReference type="HOGENOM" id="CLU_066042_4_0_1"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="273" mass="30149" checksum="50EC6EC27A4FB18E" modified="2015-04-29" version="1">MAPTHHYNLVNDDSDDTKAELDNSSLPPNTPSWKHAFYLLLAASAGLGAAFGVVLASSLLKPSTSIVSEGNATSIASACNATTNTPLSADIVAPAPLTQQLSVQTNKTDPLEGVVLDCGWSPEEARAKGCVYDVMMQDWVPEPCYDGLLTERYLARGNYTWYADIEGTVMSDEEMRKGNHREAWMSGDYHKDHCIFSWEKLIRAMRNNKPISQELVSYDHVLHCHHQTLGEEGSMRKRDGAIGVRAPTNYAKCALYSTWKADFIPDKHPSDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPP3</accession>
    <name>A0A0D1YPP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_04372</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237397.1">
        <property type="nucleotide sequence ID" value="XM_016378720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPP3"/>
    <dbReference type="STRING" id="91928.A0A0D1YPP3"/>
    <dbReference type="GeneID" id="27331455"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04372"/>
    <dbReference type="HOGENOM" id="CLU_048151_0_0_1"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW17181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="301" mass="34134" checksum="120ECECB301A4161" modified="2015-04-29" version="1">MGYLSAARYGKDNIRLYKVERDEATKTHTVYEMTVCVLLEGEIDPSYTEADNSVVVATDSMKNTTYILAKQNPIHPPELFASTLGNHFIQKYKHIHAAHISIVQHRWTRMTIDGKPHPHSFFRDGNEKRVVQADIFEGKGIEIRSGISDLLVLKSTGSEFHHFVRDEFTTLPDVYDRILSTSVDAGWKWSTFSGLDVVKKATSKFDETWSKSREITFRLFATEESPSVQNTMYKMGQEILAAQPLVAAVDYSLPNKHYFEIDLSWHNGLKNTGKDAEVYAPQSDPNGLIKCTVSREVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQZ6</accession>
    <name>A0A0D1YQZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237872.1">
        <property type="nucleotide sequence ID" value="XM_016379195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YQZ6"/>
    <dbReference type="STRING" id="91928.A0A0D1YQZ6"/>
    <dbReference type="GeneID" id="27331934"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04851"/>
    <dbReference type="HOGENOM" id="CLU_1034517_0_0_1"/>
    <dbReference type="OrthoDB" id="2141239at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237114" evidence="2">
        <location>
            <begin position="19"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="256" mass="27880" checksum="EBF791A7AEF5FB27" modified="2015-04-29" version="1">MKVETAAVALLFATSSLAAPRARLSEKTLKEDPDFGLCIPTMKFEGGLGGRSAGDFTFLPTDPLCARGQQEALNPNIITNRICDQLSTACNANEAAKELCRDAQAKIRTLGTRNKSTADTWNTLLGFGGALTNPDGGLSEPGFRSKDLKIKREEVTTIERRFIECRTDVWLDDCNGWSAPEPVVKREVIEPAPEPVVKREAEPEPEPEAAPTPAAEPAVVKRDVEAAPVENKAKRAIENFVECSTDVWLDNCNGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSU1</accession>
    <name>A0A0D1YSU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238562.1">
        <property type="nucleotide sequence ID" value="XM_016376992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YSU1"/>
    <dbReference type="STRING" id="91928.A0A0D1YSU1"/>
    <dbReference type="GeneID" id="27329717"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02634"/>
    <dbReference type="HOGENOM" id="CLU_012368_2_0_1"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="560" mass="62229" checksum="229130E6FF36F673" modified="2015-04-29" version="1">MCGIYFSVAKDRHILPDQPTVDALHARGPDSYKVFQTTDNDEKLHLTFISSVLALRGQNIQEQPLHDPVSRSVLCWNGEAWKSDGVPVEGNDSAYIWRLLQISLAHPHDRQHRIAQVLSHIAGPFAFIFYDAPTATVYYGRDRLGRRSLLINQRDYGSLTLASTSPNPSGTATAPSEVSTNTIHFFQFQEGSILQGKLPWASELYPINKGLPDSEIAALPSHESVDGLLVHLRESLMLRSVDIRDHSHPQMTADAAKVAILFSGGLDCTLLARIIHEILPSDEVVDLLNVAFENPRSLAAKGRIQASAYEQCPDRVTGRSSFTEICEVCPQRKWRFVAINVPYTEAVAHKPIIIRLMYPHNTEMDLSIAMALYFAARGQGELLEVYSNVCSEPIPYLSTARVLISGLGADELYAGYSRHAAAFSREGFQGLADELEMDFNRIGSRNLGRDDRVMSSWGKEIRYPYLDEDFVRFSLDLPVWEKAGFRRGRPVPKHHEATGLASTPGDLEPAKMLLRLAAWRLGLRRAAAERKRAIQFGARTAKMDAGKGRTKGTDVLAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUH3</accession>
    <name>A0A0D1YUH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_03195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239122.1">
        <property type="nucleotide sequence ID" value="XM_016377552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUH3"/>
    <dbReference type="STRING" id="91928.A0A0D1YUH3"/>
    <dbReference type="GeneID" id="27330278"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03195"/>
    <dbReference type="HOGENOM" id="CLU_022829_2_1_1"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="249"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW18906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="614" mass="70029" checksum="91DA075C9F320137" modified="2015-04-29" version="1">MSQDNDISDNESIDSQAEWEYDEGIPQVQDPFIQRYMAGRSALIEQEKKQRHDVMFKKTMSPLAKQAAKIMGAIRRRELRDVWTSEFEESLMDANGGNLYPGMMFTLARDRIEKTDLWKIVERMPKGALLHAHLEAMIDIDWLIDQVLAEKGMCILTAQEGGLSDAKKRESAFLDFRYYDDAEVQKLKGAGGGAAGIWTTGYKPHTPVPIREAQRTFPDDDTTFKKWLASRCMITAEESLCHHHGLNAIWRKFQSTFLVIGGMLFYEPIFRRAIQRLLGQLAADGITYVELRTAFKFEYRKTGQTKATPGRFDTFFKELGEELDKFKAKPEGKKFNGARIIWTSVRRMDNRAIADAMKECIAMKTKYPHLLCGYDFVAQEDMGRTLQDLVPMIFWFRKQCAEAGVDLPFFFHAGECLGDGDETDNNLFDAVLLGTRRIGHGYSLYKHPLLIDMVKEKKILVESCPISNEILRLSSSILSHSLPALLSRGVPVSLNNDDPAILGHGKNGLSHDFWQSYMAFENLGLEGLGTMAENSLKWCAIEDQKTADWTKSITDGYMGKGTKARLLREWRSEFEKWCQYIVMEFPLEADDDEDVDDGEDDSDEDDEDEDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YV67</accession>
    <name>A0A0D1YV67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MJ1316 RNA cyclic group end recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239402.1">
        <property type="nucleotide sequence ID" value="XM_016377832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YV67"/>
    <dbReference type="STRING" id="91928.A0A0D1YV67"/>
    <dbReference type="GeneID" id="27330563"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03480"/>
    <dbReference type="HOGENOM" id="CLU_128310_0_0_1"/>
    <dbReference type="OrthoDB" id="10263155at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042653">
        <property type="entry name" value="Leng9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46729">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46729:SF1">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MJ1316 RNA cyclic group end recognition" evidence="2">
        <location>
            <begin position="76"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="180" mass="21157" checksum="39A8808510CF4969" modified="2015-04-29" version="1">MATESVASVPSKSQLEDISRLRGIAEKHLHQIAEERLQEQFDDAKRNEELERYAKQRRRAKLRATSPAVSTPTSRMRSAQDVLERLKWDDSLDLSKYIIGYLERFNGIQEMPATRWISEPTEEEWIPQHRIRYFKQVDESGKQSIVWDRDNRIDKIFGASVNKEADNDDRWEDSSPQLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YY92</accession>
    <name>A0A0D1YY92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SNF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240472.1">
        <property type="nucleotide sequence ID" value="XM_016375196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YY92"/>
    <dbReference type="STRING" id="91928.A0A0D1YY92"/>
    <dbReference type="GeneID" id="27327914"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00831"/>
    <dbReference type="HOGENOM" id="CLU_070147_0_0_1"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000085">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW20256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="255" mass="27655" checksum="BA33A50184F842EE" modified="2015-04-29" version="1">MSTRRGVGLGAFTNRNVTAQSYAAHGSNLKSANAASLQTQLEVFQSLLHNFALEHATTIKSNPTFRAEFARMCNAIGVDPLAGSNIKGKKADSLWAKVLGHDVNDFYFSVAVRVVELCQSTRAENGGLLGLKECCESVAKGRAIGGGLQVSEDDIEQAVKSLEPLGSGFQILTIAGKRFVRSVPKEFNNDQSTVLEVLQLLGSVTVSLLTLNLGWERARAETVIQDLLADSLVWVDSQCREPEYWSPQGLIDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z9P4</accession>
    <name>A0A0D1Z9P4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_12040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847504">
        <property type="protein sequence ID" value="KIW09697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229913.1">
        <property type="nucleotide sequence ID" value="XM_016386347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z9P4"/>
    <dbReference type="STRING" id="91928.A0A0D1Z9P4"/>
    <dbReference type="GeneID" id="27339123"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12040"/>
    <dbReference type="HOGENOM" id="CLU_1540123_0_0_1"/>
    <dbReference type="OrthoDB" id="4145609at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW09697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="188" mass="20731" checksum="68EE8625B995C0CE" modified="2015-04-29" version="1">MDRDYALDDVNQIPKLLNRVEGDDSLTEQIDHLAHCAIASLFYFELSGMPSRRDGKFIGAGFLLCSIPGVDPAFKSLLTRLAAGRAQLYVNGQPMTCNWDDDTHRDENGNFSRRINYDTGDQISITIRMGRSTPSGAPISGLPSAVLDLASEQGLNACFGTSDHRKRKRVADDDVHAAKKKCRFHCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZD74</accession>
    <name>A0A0D1ZD74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_10231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231148.1">
        <property type="nucleotide sequence ID" value="XM_016384546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZD74"/>
    <dbReference type="STRING" id="91928.A0A0D1ZD74"/>
    <dbReference type="GeneID" id="27337314"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10231"/>
    <dbReference type="HOGENOM" id="CLU_029722_0_0_1"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Orp8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="52872" checksum="AEA637F1D7A70870" modified="2015-04-29" version="1">MTSTSNTPFATPGTSTPDTRPGTPSGQQPTPTSAPADNQLQDDSSKLRTFLSLLRKFIGVTDIANVRFSLPSQLLEPIPNLEYWHYLDRPETFASIGTSDSDVGRMLEVLRFWFTKDLKYVKGKPCKPYNSTLGEFFRCQWEVPEPAPSISQPSKAPPQPPADPSGQGSDKPVRISFLTEQTSHHPPVSAYWYDCPERGIFARGYDQISAKFTGTSVRVVPGMYNRGIFITLANRDNEEYQLIHPAASLGGLLRGSLYISVADTCSVTCPKTGLKCLLTYVEESWFGKAQNRVHGLIFRYDPNDDKYTRVKDVPEKDILVKIEGCWQERITYTIPKTAAVEETEGLEPTSDKQLLIDLQPLMPIPKVTPPYEEQLPHESRSFWKEVTDAIQEKRYSDATRIKQDLEQAQRDKAAKRKELNVEFKPRFFTTVTEPNGKPELTEYGKATLENMHKQTYRLEHIPEAGVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZE38</accession>
    <name>A0A0D1ZE38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231493.1">
        <property type="nucleotide sequence ID" value="XM_016384891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZE38"/>
    <dbReference type="GeneID" id="27337660"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10577"/>
    <dbReference type="HOGENOM" id="CLU_029564_0_0_1"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="347" mass="39243" checksum="FC822E05AFAAEE5B" modified="2015-04-29" version="1">MYVPNSKWTWAFSLIALTQACIVLAFECYAFAHFQIHLESTSTNLTASRTIPTFLTLYIFGFLYQLLLVWDALRMKNTIQVIGLVMYNGGLLIYGAVQISQIKDAVFQLSEDGSIQMEVWKDTKPFLIAIPAIIGVGTALLAGCAWKLYDEFAWTIYKRISADLRMKRRYLQYQIYIALLKFDFFFFLGFTVQFVVIVTQRRAEFALTIAAIPVTIIILLAAAWFVRRENLAGTIGVIILYFGGLAYFIFKMVRMYSPSHEGPYLPARKELTSFAVLTIISILLTITNACLCASNYNKGLKPYIYKSANADDEEKPIGSAYAQYATEMSSGSKYPPARPTANRMEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZFJ6</accession>
    <name>A0A0D1ZFJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231988.1">
        <property type="nucleotide sequence ID" value="XM_016383365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZFJ6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZFJ6"/>
    <dbReference type="GeneID" id="27336127"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09044"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="307" mass="33846" checksum="651633C33B06F995" modified="2015-04-29" version="1">MFFRPLQLHLKETHSLYQSQLSVALVPDIAAVNAFDEAVKGVDGIIHTASPFVLNARDFEEDLFRPAINGTLSVLQAAQRNNPSVARVVITSSFAAHLDPSKGSRPGHTYTDADWNPVTRKDAASGDGVVAYLASKTFAEQAAWEYVTNEKPEFTIATLSPPMVYGPLIHNVENMDNLNTSAGDIYRFINGSQQEVPETNFWAFADVRDVALAHVLAFEKPQAANQRYLICSSAYSYQQICDVIREKFPELRSLTPEGKAGEPLPSVYKLDTSKAVEQLGITFTPLEKTIVGMVNSLLKLQKKLSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZFY5</accession>
    <name>A0A0D1ZFY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_09165</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232108.1">
        <property type="nucleotide sequence ID" value="XM_016383485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZFY5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZFY5"/>
    <dbReference type="GeneID" id="27336248"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09165"/>
    <dbReference type="HOGENOM" id="CLU_003041_26_1_1"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="83"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="283"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="563"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="411"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="708"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="783"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="813"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW11892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="878" mass="99049" checksum="44C11C145D9C67B3" modified="2015-04-29" version="1">MAPLGKRKRRESGPRKEYQRPRQLKRKREEEDIESLSQRVADLDPRSAVPSDNFADLPLSQTTQDGLSSSHFKTLTTIQARTIPLALQGLDILGAAKTGSGKTLAFLVPVLENLYRKRWTEYDGLGALILSPTRELAIQIFEVLRKVGRNHTFSAGLVIGGKSLQEERERLARMNILVATPGRMLQHMDQTAELDIGNLQIVVLDEADRIMDMGFQTTIDALLEHLPPDRQTLMFSATQTKKVSDLARLSLKEPEFVSVHETAESATPSGLQQNYIVTPLPNKLDTLWSFIRANTKKKILVFLSSGKQVRFVYESFRHLQPGLPLMHLHGRQKQTARLDITTKYSNSKHACLFSTDVAARGLDFPSVDWVVQVDCPEDAETYIHRVGRTARFERDGRAVLFLDPSEEEGMLAALEKKKVALEKINVRVKKMQNTIRNQLQNMCFKDPELKYLGQKAFVSYARSVHIQKDKETFNLKKLDLEGFAASLGLPGAPRVKFVKGEDAKARKNMPRQLLAALEGSDTSGDEDEGDNKAKQKQKAVRTKYDRMFERQNQDVLAAHYTKLIEDDDDEDQDAARDPSSRAANNNEDDEDEPDFLSVKRRFVAGDEALGHDSSPSASESDTENEDPMGNGTRSNSKPGKKEIRTVKLSDKAEPLIIDSHRREKLLSSRKKLLKYKGHGAHLTFDSDSDTPKDRKAYRDESTFGPDAAQREKQEFLERERERAKEMDEVDKEIARQKKREKKEQRKQRARELREQERTGGAEEDDDGVQLVPYDEDQGKSVYDDEDYSSDGEEAEEANEERRFGQPQLGKAGVEAKKRPKKWFEDASDSEDDERAVKSGGAGAGKRKKNRNGAGLEVIDQPETLEDLEAMASGLLARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZG64</accession>
    <name>A0A0D1ZG64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232178.1">
        <property type="nucleotide sequence ID" value="XM_016383555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZG64"/>
    <dbReference type="STRING" id="91928.A0A0D1ZG64"/>
    <dbReference type="GeneID" id="27336319"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09236"/>
    <dbReference type="HOGENOM" id="CLU_010101_0_0_1"/>
    <dbReference type="OrthoDB" id="4152802at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
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        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
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        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
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        <location>
            <begin position="605"/>
            <end position="634"/>
        </location>
    </feature>
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        <location>
            <begin position="679"/>
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        </location>
    </feature>
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        <location>
            <begin position="779"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="888" mass="97782" checksum="5960BA7B0125B806" modified="2015-04-29" version="1">MGFWPFGGRKNARDTRPHLQRPHTFGAKEEKDLTVRSGSESAEERGNMARNQNARSPDDRPRRLSKQRLPKNVSRGQTAPVSGPASETWNGRRSSAIEPRAHQGQEGYSQDPTSPLSVGSEEFTALPQAPTLLARRGTYDPTLTRRKSSKRKAEDYAREREIRAMSSPEYRLKRPASYSGSGPLRRDTQNIPGDFNRRLQRPNSKVSLPLPEVIQDAEDFENQGSFKVGILAALTPRPTLTYVSNPRSSTGKQPARLKPSVQEAIEEEAPSSRKRIDELADDLDAGALRELMDRDRRRHERKKAADRERLQRKLQRKADRQREEELRGRPIAASSTGSADLGTEAEEQRGRRLRDRSAGSLEMDGTAAPRIDQERPVNPFKEDPLRGNDFSSSQKRPPNRIRNPFEDEKEVDIMQDPSTQDEDEGSVVPVRSPLRTISPLKTQVNQQPLQAATISPPTSPVHQPSDLHSLSQTSGLTRKITPDVLEQEPTLRRASDQSSQQQQISSWTNFFKRGTRRKPSAAKRGRSTPSEFSNTSRESFVRKQQPPPVVVPRTFRKSNSTGVPQRTMSRFREDLPEFPISPPDSRVQSPEAITSAQAIGGQHTVPPSHSGTQDAMSLATTSSNPAMEVQQLQSGERDASAAPVSGVVLSQSLASVDSEGSWLSGKPAKRMSGGVSHPLRQSVSSITPNAVPGSFETEEEELAHDEYYNRLTPAPAARRDSGGSVGRRASSNIIDLERERQHSPIPDVPPVPAVRGGDETWHAGLGRQATVVRQASRAKSREGLLKDYGAESSDGSRRPSLDGDDEASDGEMLEALIPGTELAGAPILRARSVEYKGHARQISAGSAKLLNIRRASSVSQASTAQRSPGLAPKKTMLENRSQSPPRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZH12</accession>
    <name>A0A0D1ZH12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232453.1">
        <property type="nucleotide sequence ID" value="XM_016383830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZH12"/>
    <dbReference type="GeneID" id="27336596"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09513"/>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF8">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="64262" checksum="527DF3422E5FBE3D" modified="2015-04-29" version="1">MVLDGFARTNGTAEPVVSTSGVVLLNQPLHTKRKLRLICIGAGLSGIAAAYKYQRDLENVEIIIYEKNDDVGGTWYENRYPGCACDIPAHGYTYSWEGNPNWSRFYVERPEIFAYYKSCAIKWNCMKYIKLQHRVVEARWSESEKGWHVKVENQEGTVIEDFCHVLLNCNGVLNNWKWPDIRGLHDFKGKLLHSARWDSDWDYTGKTVAVIGAGSSGIQIVPKMQKVCKSVVSFNRSPNWITPEFSQGLASDGRATVYTREEMDRFKTDKKYFLEYRKKVQNFGSATYPLYYKNSDMQKQVFAKYAELMRQRLNGNEELCEKLIPKFHVGCRRFTPGEGYLESLLEPNVTVVTCEIDKVTETGIDLIDGRHFDLDAIVCATGFDCSHRPPFPIIGRNGRNLSEYWKDEPLHYLSVAAPGFPNYFITGGPNSPIANGSLISGVETEIDYAFKCIVKMQTENVSSMEPTEEAMRDFIEYRNAIMEEMVWSSTCRSWFKNGKVDGPVIGPSVGSTWHFNEVLKEPRYEDYHLTYCTPNRFTYFGMGRTIREVEGADMATHLTEPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHS5</accession>
    <name>A0A0D1ZHS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_09729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3 7">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232668.1">
        <property type="nucleotide sequence ID" value="XM_016384045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHS5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZHS5"/>
    <dbReference type="GeneID" id="27336812"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09729"/>
    <dbReference type="HOGENOM" id="CLU_081350_0_0_1"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029764">
        <property type="entry name" value="RSM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR029764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="279" mass="32078" checksum="C032DADD449B2DCB" modified="2015-04-29" version="1">MGRLDLTAINVRKTVLQNIASGRITTTPIWTDVVRDVPPAQILIRQQPQKHRLTKVRTRTLPNGRIQQYAQVMEPKKPKSTKTQNLFTPRHLRYEEDELRKAFFNDHPWELARPRVVLETSGDQYKNADWSTGVQQPGIALSGESVVQRQLWLLENIPDITVPQAYDIARKEFYALRRSEEIRNRIAAEEARHMGARFGKSAIQVSMGIENDMYNDWDAWAHQMVNEQTQRLAAFSGTVMTSEEDALRDVKDEEERPAIGASVFAQQQKTDARSQRKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIN6</accession>
    <name>A0A0D1ZIN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232933.1">
        <property type="nucleotide sequence ID" value="XM_016384310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIN6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZIN6"/>
    <dbReference type="GeneID" id="27337078"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09995"/>
    <dbReference type="HOGENOM" id="CLU_008053_1_0_1"/>
    <dbReference type="OrthoDB" id="9997422at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="650" mass="72961" checksum="59344B138C0DD11C" modified="2015-04-29" version="1">MIPKNILRLCQSGVSVSAELAKNPALSAHEVVGQLFRQHIEDEEMAKKQALNGETEEDLDQALACGRWGTAKPSKLFLRIFHDVLCTLEKNPLTGVCSPSLMGSTGVCPLTIIAPIPDICRHMSNVIARAEEEVFLATNFWMHSESSMLITNSIRELNRKAVALNKRIVVKIIYDRGSLQQLINNHLVVEPKTYADPNGPIRLPHPDDIPNIDLEVINYHQPVFGTFHCKYMIADRRIAIIQSNNIQDNDNLEIMSQWEGPIVDSFYDMALISWHNAMRPPLPRLNRPAAGQPTPTFDSHSYASLFDQSGNLKEVYHSTETMPHNHENLRDLAKDGSEVNLPMHTSNDAHYDPDIKSEVLRATATMCPEHGERRIDAITRLLNTTIQTNTKASAPDIAPADAMTPFIPLPRHDPVPMAMVCREPCGKPGKGSLHTPQNEAFMSALRHAEQSVFIQTPNLNAEDLIPEIIKACRRGVHVEYWYCLGYNDAGELLPGQDGHNEMVAHRLYKELNEQYHRYLDIYAYVAKDQIHPIHNKFKKRSCHIKIMLIDGHIAIQGNGNQDTQSWYHSQETNIMFDSALIVGRWMEGLRQNENTHIYGKVEKGGLESGCWRDPQTGKQAEGAIGVDPGKFAWARGFIGAVQRVRGVGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJ37</accession>
    <name>A0A0D1ZJ37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233083.1">
        <property type="nucleotide sequence ID" value="XM_016382380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZJ37"/>
    <dbReference type="STRING" id="91928.A0A0D1ZJ37"/>
    <dbReference type="GeneID" id="27335137"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08054"/>
    <dbReference type="HOGENOM" id="CLU_053603_1_0_1"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="179"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW12867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="308" mass="35466" checksum="98678FDCC8AD87AC" modified="2015-04-29" version="1">MSERKVLTKYYPPDFDPTKIGRTPKHLRPTGPKTIPVRLMAPFSMKCTSCGEYIYKGRKFNARKETTDEKYLNITIYRFYIRCTRCSSEITFKTDPKNMDYTCERGAKRNFESWRDPESTELKETDEERLDRLEREEAEEAENAERNAMEELEEKMEESKREMQVADALDEIMQRNARIERGAKGSKEEEILVQSRDIEREQREAQEREDAEAARRAFESNKVAQARLEQATEAQIQNSKKTEEDTTPQPPPSFERVKKTKKPLVPGLVRKPQATTAAAAPPTTTTTTTTSSAKPIGLNLGDYDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJU2</accession>
    <name>A0A0D1ZJU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233293.1">
        <property type="nucleotide sequence ID" value="XM_016382590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZJU2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZJU2"/>
    <dbReference type="GeneID" id="27335347"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08264"/>
    <dbReference type="HOGENOM" id="CLU_048982_0_0_1"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="435" mass="46868" checksum="5C7C3C7EF4054053" modified="2015-04-29" version="1">MEHQTQPGGARIFSILNDNDCPSFVIRHHEPSPPSSEKTSPLLSPRPRLERPHLVRHAGYRRTSSFSSSTASTPPLVRQSSSESGSSMDSSPSPITPAYNYVDNTLLPYDPLLRQDMTGYVPSPSTITPFMEQQLMINPNMADPQYSGKSLAIPPIMPPQYPLVPGPVHPSLQLQPLAVPAPIPNGLAPPATSAPPSSTPSATSPTTTGSAPPKKNKYPCPYAQSHHCQSTFTTSGHAARHGKKHTGEKGVHCPICNKAFTRKDNMKQHERTHKGSQSGTTSDDSSRRSKAAMTRDAVKAKQIKKHDSMNSEASRRSSQIHSPLSEGTSLAPTAVETPVLSHEDTSLYLEPRQMLMPIQTIPESVSPNSLYPPLADDPLLGAPLLQPPLLSKGIGNGMVPNGLVPPTLIRGFSDLDTLAQAAESFDPYYQTSQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZKV3</accession>
    <name>A0A0D1ZKV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233668.1">
        <property type="nucleotide sequence ID" value="XM_016382965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZKV3"/>
    <dbReference type="GeneID" id="27335723"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08640"/>
    <dbReference type="HOGENOM" id="CLU_481485_0_0_1"/>
    <dbReference type="OrthoDB" id="4160225at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="570" mass="61490" checksum="05908E58AE168000" modified="2015-04-29" version="1">MTKLQKQPPPAYPGSGRSTSTTTTSTAPLQGAVPYENLPQSTQQPVPVMTAVTPSSYNDLPSTNPFSPNFTPPSAALNADQQSPFSPVSPLIETPSVQRRSEASIVAPTPQRPDANQRRSVDLRRLDGKPYSGSTPVERHAKPVRVARDMHDGALPPVYKRRDSDLVKPAEGAQGSACRHCGKKCAEGQECSHCGKRKASLPKANSTTPPVSQHTRTTSEGVNSHRSRISETTTAGPSSSPGSSPGRKSCCNKCGRYKRPGSIDASNPSHAHAATEPMPMASHPALRVHQAGLSVQPGMSGLRSSVYPQIDVIPPSTTSYKPTTQFPPSIYGDESPLVGRDVPPEAKPSRHSSLIRSLSRRLSRRDKKKEKATPPGSPLPSQQVAAGETQSGEQSAGRLINMISAAMQGPLAGTERDTQYSRLTPDEQPDRPTTPFSFVGGKDEEEVFEMVHVRDRESLSDSDSWKEGANEQITITRPDSGVIPQDTIDVIPRPKSAEPFSQHLAVPEAERPQITRFKSLRSGVSRMNSNISRSTSLKRLGSLKTAHHAWYRDDMAIEGAMGNEHAVPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZMC3</accession>
    <name>A0A0D1ZMC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234173.1">
        <property type="nucleotide sequence ID" value="XM_016381071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZMC3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZMC3"/>
    <dbReference type="GeneID" id="27333821"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06738"/>
    <dbReference type="HOGENOM" id="CLU_010236_4_2_1"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="249"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW13957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="637" mass="70395" checksum="D68873EB41D6B1C5" modified="2015-04-29" version="1">MVAQRNAAFAEESAEVEVLLASLGKTRDLTKKIAASLARLDASGQIVNEAIGPVYGNTKQLQVTSRNIDRVNEAIEKLRQPLDARGREENIIRQGPKSAGLPQYLAALKRVDKALTDLNSSGLRSNQQAISEFHNLLLTGVNQLNDLYRKMLQEDAKTIEPLHFITKQISFPTIAQEKAQTLGQISMAIASAGAHSAKLGQRDDDAAARMYAEIRGDYINSSLQNLSMASISTSKRRNADTAIYREGSSGVGAYAKALESMLLAESENTSRIFRNDGGRVFGLTCSKPLSTFARTLSDLNSFIKTRILTDCFLAYEILDLVTPLSYRLDSRTGQLRSQFADALRPLRETARSSFSDLITQTRRQAETISTLPPDGNTIPLVSETAKRLQTLANFDRPLLVLLSSIGDGNWKAPSTSAGLASQSSLNLELTPSAENPNLLSHYLLDVVDTLLNTLNTRSQTIHPKKSMQGIFQLNSAAVLARAVQSSPDLARYIGISPHNERLEKFRKRATELYMTSWREASMHLFDTIHTSGSRPISGQGPGQAIDSTSIVKSLNSKDKDKIKEKFKVFNTSFDELVVRHKGLHMENEVRSYISREITALIEPLYARFWDRYHEVDKGKGKVVKYSKGELSGMLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZMG0</accession>
    <name>A0A0D1ZMG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cystinosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_06763</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234198.1">
        <property type="nucleotide sequence ID" value="XM_016381096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZMG0"/>
    <dbReference type="GeneID" id="27333846"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06763"/>
    <dbReference type="HOGENOM" id="CLU_046327_0_1_1"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW13982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31630" checksum="B9E87CCEA3264AF2" modified="2015-04-29" version="1">MTRSSDGGWVTFGKALSSLLGWIYTLSWSASFYPQPWLNWKRKSTLGLAIDFPLLNVLGFLCYSISSCGFLYSATIRNQYAARHPASPEPTVQFNDMVFGAHAVVLVVLTYSQFYPWLWGFKVSSRQRAAKPVLGIVWGSVLAILAVVGLVIHHSGFQQQDPQDWAWIDVLYTLGYVKLICTFVKYIPQVIVNFERKSTVGWSILQILFDITGGVLSLIQLVIDSSFQGDWSGITGNPLKLGLSNISIMFDVIFIIQHFLLYPDQEDRMSEEDESERPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZNB1</accession>
    <name>A0A0D1ZNB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_07114</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234548.1">
        <property type="nucleotide sequence ID" value="XM_016381446.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1ZNB1"/>
    <dbReference type="GeneID" id="27334197"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07114"/>
    <dbReference type="HOGENOM" id="CLU_000135_0_0_1"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017148">
        <property type="entry name" value="VPS13_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037235">
        <property type="entry name" value="VPS13_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="7">
        <location>
            <begin position="1100"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="8">
        <location>
            <begin position="1948"/>
            <end position="2522"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="9">
        <location>
            <begin position="3046"/>
            <end position="3152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="838"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1390"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1554"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1713"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="846"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1721"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1733"/>
            <end position="1753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="3177" mass="355956" checksum="4C7E8165C26B0983" modified="2015-04-29" version="1">MLEGLVANLLNRFLGMYVKNFDPKQLNVGIWSGDVKLRNLELRREALDQLHLPINVVEGRLGELTISIPWSNLRGKPVRVNIEDVFLLSAPKSEDDYDAEEEEKRAVAVKLEKLESAELLKERNTEAMSPEEQQKNQSFTQSLVTAIVDNLQVSIKNIHIRYEDSIATPGHPFAVGVTLKEMSAVSTDSEWRPTFIQSTSDTTHKLAVLNSLAVYWNSDADLFGTGRGGDVGADAQEIDKQDLLRRFKEGIEDTGNSQYLLKPVSGRAGIEMDKTGRTDRPKLKARLLFQELGFILDEDQYRDALMLVDLMHYFIRHHQYKRVQPEKSPKDDPRAWLKFAGSAVLDKIHDRNRKWTWDYFKERRDMRLQYIDLFKKKKKDQKLTEQETKDLNDLEYKLSYEDLRFWRSLAHSQLRKENVGVKKPAPKQTWGQWMWGSKPAETDKDDDSAMTDEQRKELYNAIDWDEKKAIAESVDLPRETVKLQLETSLRTGSFTLKRDPHGQGTEVLKLVFDNFRAKALQRPDSLLADVALGGFRVYDGTTEGSLFPQIVKVKGVEDQPKDEQRSEDGDSLEGSQETDEKASNGENVEDSLFHLVLENHPLDESADTKIMLKLKSLEFIHNPKFVVEIAKFFKPPERHMESIGALLETAGATVEEIRQQTRAGLEFALEEHRTINANLDIQAPIFIIPESITEESTLCMILDAGHVSLNSELVDKDTMNDIRSKQKQQYTEQDFKQLEGLMYDKFHLKLESTQVLIGPGIEATRAELEASDDSKQMHIIDRISMGFLLENSIVPKAPDITKTRISGTLPVLHASLSDKKYKNLMRLLEVAVPKFDSAPDASGTDKVNEANRQEDNVRSKRKSVQLLETKDVPIIDPDSDSEDASTQVVAKAEAHEAPANIHQRNFEINFTVEKLQASLYKADPEGKKPDQLLVELVAEHFFFDFYLRPYDMVAEVLLRSVTVDDHIEEEPLPEFKQIISSKGFEAEEGKDLLNVKFVKVNPESPEFQSTYEGIATNLDVSVSTINVIVTRRTLLTLLDFVLTTFAGAPKQNQAQLDQGSDTSEVQDSPDTSPAKQQQDKIRIKAALTSIALILNNDGVRLATLSLNSGDVGIFLDAGTMQVKARLGSLSLVDDVNQGAPENSPLRRLIAIEGDDLADFKYQTFNSARSDYPGYDSGIFLRSGSIKVNFLEEPFRKIMEFGVKFGKMQAIFNAARQAAAEQATQVQESAQKMHFDIVIKTPIVVFPRAMVDDRPRDLLTAYLGEIYASNKFVGVQGQKGGPLVNKLSTGIRHIRLTTEFHYEDGQSQELEMIDQVDLDFKIRYLEHQAGLERPDLEIDGSMSPINLRASQAQFKFLMELSKTIPAAFATENESDEDIAEELPAETAKAIQNEEPSTEESAVGTYQGPELGSSDETWTKLNFVFKAPTISLELFLAEEEHPTENFDAASISKFALNETNVKLRMISDGAMEAELLVHSFTIRDSRKQETNKFRKIMSLINTDVQQQFMASVSITGGKERHMIVMLTIDSPRIIVALDYVFALQAFANAALQSDEPPPIADLDDSTDGGSLKSPSEERGDILAEDQGGTASESSSMTMSFRVNVVDAQVILIANPAISNTEAIVLGTKEVLVGKQNATTLQISKVGMFLCRMDKFETSRLRILDDFSVSMSMDSRSQGADSSLTSISIEVEPLVLRLSLRDILLAMQIVQKASSTMAQPKMQQDSEPKKIKDVKSSSTAASTKRKSVAGQTISTTKRSKRSKSISKPAAKQPPKSSVVMSREELIATVDGIRVILIGDLHELPLLDWSVKQFQVDVRDWSGAMAADTKIDTFINVYNFSKSAWEPLIEPWKLGFHMSKELHPEVLSMELYSHKNMELTITSATIALASKSFNFLSTDEDILSKPRVADAPYRIRNYTGFDLSVWADEKSDNAAAAKLSDGEEYAWRFEDATSMRESLTPEGNAGLVGVKLEGSGFESVNRIPVIREGETLYNLKPRKDGVQHRMLVEVKLGSDNVKYITFRSPLLVENRTQIPIEVGVFSPEQGDLLKIEKVAPGDAKPAPVGAAFVHSLLIRPDQGFGYGWSSDQLFWKDLLKKSTRTLTCAAEGRDESPPFFFQMHAAYNSKDPMTRIYPYMRIQISAPVEVQNLLPYDFKYRIYDKNTKKDWTNFLRKGGISPVHVVELSHLLLLSVELENTPFRQSDFAIINSNTQEEFRREKAVQLRDEHGAHLKLKLHYTNMKDSGGAFRVSIYSPYVLLNKTGLDMSVQSKAFFGSAKTAASQGARTSSGHGKALPMLYSYATDDRKNRSLLKIGDSTWSKPQSFDAIGSAYEVVLTSASGKSELHVGVSVTEGEGKYSLSKVVTIAPRFMLKNKIGEDIELREPGSSEVIKMANNDLVPIYFMRQCPEKQLCMCFPGVNNQWSSPFNLANVGMTHVKLAKHGQRQRLVRVEIILEDATLFLHFSIETKHWPFSMRNESDTEFLFFQANPNIAEDEEEDQGSGWKPIRYKLPPRSIMPYAWDYPASKNKELVLTARGRERYVKLMEIGNLIPIKLPPDGRGGPPKVIDVNIVADGPTQTLVLSNYKPSKSLYRQKTGMTNASQTSLNQGFEVKQIESELNFKAELRLAGIGVSLVNSNLKELMYLTWREIEFKYGESKLYQTLNATVKWIQIDNQLYGGIFPILLYPSVVPKTGKEMETHPIFHAMVTRVKDDSYGVLYIKYATLLLQQITVELDEDFIFAMLDFLKVPGASWAEEKEGKLCDEDLDIPEPTREQQGQDVYFELLHLQPIQLDLSFVRTEHINAEDNFVNSPLMFFVNVMTMSIGNVNDAPIKLNALLLENARVSVPALVANIQNHYTQEVLRQVHIILGSADFLGNPVGLFNSVSSGVADIFYEPYQGLVMTDRPQELGLGIAKGASSFVKKSVFGFSDSMAKFTGSVSKGLAAATMDKEFQDQRRMSKNRNRPKHALYGVTSGGNAFAASMASGIGGLARHPLEGAEKEGALGFVKGVGKGFLGLATKPAIGAFDLASNVAEGVRNTTTVFDAEGLDRVRLTRFIGMDGIVRPYSQREALGQFWLKTADDGKYFNEDYIAHLELEGRDMMVVITYDRILMIRTKKLRVEWDVRLTDIQTISKERTGMSIGLKGGANGPFIPVTDEGSRNWLYKQIAIAVNAFNDKYNAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZNC1</accession>
    <name>A0A0D1ZNC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234558.1">
        <property type="nucleotide sequence ID" value="XM_016381456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZNC1"/>
    <dbReference type="GeneID" id="27334207"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07124"/>
    <dbReference type="HOGENOM" id="CLU_700261_0_0_1"/>
    <dbReference type="OrthoDB" id="9925208at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="275"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="394" mass="45157" checksum="1EB2B8DA3C24E1C9" modified="2015-04-29" version="1">MPKAIAGSVEDDWIQLTIKGNGRGVVTMDFDKNAKLSELMFSFWELTCQPPHPAAFLYKGIKLRARDTPMMLEMKDNDIIEYRRIRRHPRLIQVDDMLLLIEAGQQFVRKMDPIVEWERFNKDEVAEYRATIHSIQLYFSQAQASLKALVENEAFPLDGDATRVMRKRQAQLANVLIRLFRVHHLVYNKGYQAKVHPLPFRTGAKCLLAVENLAALASVVRNLQYPDVWERVPLSIPGLLKENPEPVKPVEKRTGGRGVWTQEIPQLRQEQHGECLVCHEPCTSTTNTRRVFRKNGVATCTDCCGKAVHPRCLARWFAYERLSTDHGDTGTCPACRHVFPPQVAMLIMYMAIAHLGLALDASPKFRAWLARLPKQGAGSYLDVYRDHSHWFWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPC7</accession>
    <name>A0A0D1ZPC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234878.1">
        <property type="nucleotide sequence ID" value="XM_016381776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPC7"/>
    <dbReference type="GeneID" id="27334529"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07446"/>
    <dbReference type="HOGENOM" id="CLU_032923_1_0_1"/>
    <dbReference type="OrthoDB" id="5068804at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="376" mass="41134" checksum="348439B75FBA91F6" modified="2015-04-29" version="1">MADPLSVSAGLLAVITAAIQSSKALYDTVRSFQNHRRAVVCLLDELAALNQVLQSLQSLVVSNASAFTSLKLPLERCSQACSDFEGLLIKCSKHSGGARTSFRDWARLKYMGNDVNGFTNMIAGYKSTICIALADANLHSTSVTLKVLNEYKDLVQSTTQDLEDHLKDIDAKLQSHASDAEQASETMQLDIQRIKNEKGNVEMCLQFCNEVLSHINEMHFPPIVGQGKATERSSPVLQARDFTRAETITLSGLRVCSDALSETIKHLHSERDSSSLENDTAVEDPGAGVQTLEGEFKSAKRLLEICNGAAGRASEKRVHVVEDMRVGHDGQQLFVSTLGDLFDIKGVSAGDRAIQFVGSVSDRTLQQYFTTQTQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZS23</accession>
    <name>A0A0D1ZS23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235798.1">
        <property type="nucleotide sequence ID" value="XM_016379971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZS23"/>
    <dbReference type="STRING" id="91928.A0A0D1ZS23"/>
    <dbReference type="GeneID" id="27332713"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05630"/>
    <dbReference type="HOGENOM" id="CLU_034747_0_0_1"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38053" checksum="CFB7A1C0B8E2BD9A" modified="2015-04-29" version="1">MPLIEELPVSGGTRISHGWAYVPDTGATVTAAQPSSRKRGRDGNIASAASNAQAAHKLSAKQEKAIQQRLNDLGKENHREIHIAIPKRETAAGTAARAKSTPNVRRILGYSRTFQHYLADEEAGVNVYGAAAAIAAGASGGASASTAASSKNTDARKRTETKTSAQKRTSSVKETRKAGSAAPPPTTKGKRGGRTRGNAATNAVEGDGDIEMIDAPPSPAANVKKETTTEVQQNVQQQGKKTETQQQAIYDPALDKDPLLKTRDVPKPPTERVMQALLAEPMLSYNAARAKPLQGADNPEFEIRTGSSVLMAKPQRWFCSVCGYWGKVRCRHGCGERVCGLLECWRGHEGVCALAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZSB4</accession>
    <name>A0A0D1ZSB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_05762</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235928.1">
        <property type="nucleotide sequence ID" value="XM_016380101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZSB4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZSB4"/>
    <dbReference type="GeneID" id="27332845"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05762"/>
    <dbReference type="HOGENOM" id="CLU_002125_2_0_1"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="13">
        <location>
            <begin position="236"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="461"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="650"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="687"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1026"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1026"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1072"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1098"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1147"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1170"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW15712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1235" mass="137044" checksum="9C27C5EAA91030B5" modified="2015-04-29" version="1">MAAQQPQSGKPWSGNNKIPTVNQFIANLDRDKANRDKNIDEQRRNLGASSEITPHKNEQQKKEGKTVTDPVTGKDIVIADVGKDYMKRAENPVLSVPNANLGKPTPVATDPSQKNPEYKEKQDITAPPDPIAEGSTSDVPIHGEKTNILFHPTPSVSYEPMFEVLEKRAGGLCIAILLSVVFLGKMFGGSLKGLVPLGMCLASGVWLWMKEVVRSGREVEWSSEQTRGETATANLLPESVEWMNTFLSVVWGLINPEMFAAVADTLEDVMQASVPAVINNVRVAEIDQGNNPIRILSLRALPDSRVQDLKQSIHEENKKTKDPQEAAADEEGGDYYNLEIAFAYHAKPTGQSASSRARNMHMNLVFYLGIKGLIGVPLPIFVELQELVGTVRLRLQMTPEPPFAKSLTFTLMGVPHVQAGCIPMVKRGVNILNLPLISNFVNYAIGAAASMYVAPKSMQIDLKAILQGDDITKDVQALGVMWIRIHRAIGLSKQDRRGSKYGGSDPYINLSFSKYGKPMYCTRVITDDLNPVWEETAALLVTPDLVKANEQLSVELWDSDRNSADDMVGKVELSIQKMIQHPGKMYPQISKLAGVADGSEMPGELHWEVGYFGKPKFRPALRTDGKDKNLPDKLKNDAQFQDEKGTLDTEEADAVAHTPPDPLWPSGVLSVVVHQIVNLELENIKGSDGNRKGKEFEPAKPFGEGTDEESNKLPTSYCTILFNDTLVYRTRAKAVSSKPIFNAGTERFMRDWRSGIVTVTVRDQRNREHDPILGVVPLRLSEILTTSSQVTRWYPLDGGIGFGRIRISLLFRSVETRLPPNMLGWDVGTFEFLSSQIIAKGWDHNTKLKLRTGGSVGKIPRERCHKTEAGDGVFFDVSPENNHHVRLPVKHRYRSPVIFEFHVAGKRGAAAYASIWLQNLVDNEEAPIDIPIWKTKNGNRLCQNYITEENVKAFMDKGLEDLEEVGRLQFRGRFKAGMDESHRDFIVDNDTRETFETWECCLAEGVRQRVVEAEVPDNIREMHEASLTEGRDVLKQQTSEHEKHKWLSKSGEDWSGAFSHDPRAYTNKKHEKIAEPGKDDPPHDPYAPSDDEEHDQVSYDSDGSESSSDLGITDASNAPEGGFHNNAQENIDGNAEGRANGRPSGETVATTDTNYTTMTEGSSGSVQPVSRRDSKWEKKASSRAEARKHRGLAQWTPARNVKFAKDEAKIGVSKLKRRLGMGGLAGREPGVETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZT72</accession>
    <name>A0A0D1ZT72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diacetyl reductase [(S)-acetoin forming]</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236188.1">
        <property type="nucleotide sequence ID" value="XM_016380361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZT72"/>
    <dbReference type="STRING" id="91928.A0A0D1ZT72"/>
    <dbReference type="GeneID" id="27333105"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06022"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="28342" checksum="5ABDB185AA811562" modified="2015-04-29" version="1">MVKRTAIVTGSSRGIGEAIVRRLAVEGYAVCVNDVSANKAGIDKLVSELNQAHGSGSAIGVVADVTSSSEVQALIKESVDKLGPLTVMVANAGIAQVAPALDISDEDVQRMFNVNFMGVWLCYTHAARQMIAQGPVPEGSTSGYKILGAASIVAFKPFPLLAHYSASKWAVRGFTQVFAMEMAKHKITVNAYAPGIVGTAMWDLIDEKLGAIEGRGKGESVKKYSSDLTALGRVSVPEDVGNPVGGFLCSKDSDFMTGQTIVIDGGIIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTS5</accession>
    <name>A0A0D1ZTS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236398.1">
        <property type="nucleotide sequence ID" value="XM_016380571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZTS5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZTS5"/>
    <dbReference type="GeneID" id="27333316"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06233"/>
    <dbReference type="HOGENOM" id="CLU_070611_0_0_1"/>
    <dbReference type="OrthoDB" id="4448936at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="335" mass="37466" checksum="470AF4C9D771CE06" modified="2015-04-29" version="1">MPLVFKATTLLSDVHLILRVHLLTEWFAYDSAISVGANTPGPTDKSLPSEKLSETSSHPDLATRLNGLVSEIWAHEQDGGIRGEQKRKLEQAMRDIELVLEDDLSGADDSETSTPQSGIPIEEDRQTASEQDLDAVRTSLAATVEAMRMRHQEQRHLHQLTVQKLEAVAQRCLDQEKQLREHAENMAILQHENHLLRQQNDRMHSELNHAHTESAKKEVAVNAMSSAVSGLEGWINASPTPTHSARRVVTRGRGRFRGRYYVDETPEPSPRIGQDGMPDAKALHEGVTAWLRGFRDVEEELRALKHSNPSPRKAGKSNFDFSDDEWGDFESAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWM6</accession>
    <name>A0A0D1ZWM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L2-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237293.1">
        <property type="nucleotide sequence ID" value="XM_016378616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWM6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZWM6"/>
    <dbReference type="GeneID" id="27331351"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04268"/>
    <dbReference type="HOGENOM" id="CLU_036235_0_3_1"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="254" mass="27422" checksum="27DF191266B8B514" modified="2015-04-29" version="1">MGRVIRNQRKGRGSIFTAHTRLNKAPAKFRTLDFSERHGYVRGIVKDIIHDPGRGAPLAKVEFRDPYSFKKRAETFIANEGLYTGQFIYAGKNASLSIGNVLPLGQVPEGTVVSNVEEKVGDRGALGRTSGNYVTVIGHNPDEGKTRVKLPSGAKKVILSSARGMIGIVAGGGRTDKPMLKASRAKHKFAVKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRYAAQGQKAGLIAARRTGLLRGTQKTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZY45</accession>
    <name>A0A0D1ZY45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KIW17542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016379081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZY45"/>
    <dbReference type="STRING" id="91928.A0A0D1ZY45"/>
    <dbReference type="GeneID" id="27331819"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04736"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_11_1"/>
    <dbReference type="OrthoDB" id="4109642at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="27683" checksum="17CE53E018C6243F" modified="2015-04-29" version="1">MTGRVVFLTGANGGIGYEITKQFLAQPVTKLALVVAIDLHVDRLRGLLPEHEGRLEVIAGDISDRATSEAGVAAAISRSGRLDSIILNAGIQGPVGSMLTVDVAAWKRVMDINFFALVHSIQVAAPHLHKTGGTIIMTTSGVSLGPFPEWSSYGSSKAAMNYINLCWQKEDPTVRSVCVRPGIVDTGMQTAVRTELKDDLPKSTYEWLKGVHDRGELLSPDVPAKTFVYFALKGIPDDMVSTIVDYNDGRVNFDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZY90</accession>
    <name>A0A0D1ZY90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237828.1">
        <property type="nucleotide sequence ID" value="XM_016379151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZY90"/>
    <dbReference type="STRING" id="91928.A0A0D1ZY90"/>
    <dbReference type="GeneID" id="27331890"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04807"/>
    <dbReference type="HOGENOM" id="CLU_006512_0_0_1"/>
    <dbReference type="OrthoDB" id="1883964at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="930"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
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        <location>
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            <end position="265"/>
        </location>
    </feature>
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        <location>
            <begin position="282"/>
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        </location>
    </feature>
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        <location>
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            <end position="313"/>
        </location>
    </feature>
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            <end position="330"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="525"/>
        </location>
    </feature>
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        <location>
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            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1251" mass="135481" checksum="962AAFCB805EBCF9" modified="2015-04-29" version="1">MNPNHSYNYSQSTPGPPQPPWQAPPRKSGWADPRFQPQPLLSPQNANYHGFGPPLPPPPDPSQQPPAQVDTSAWGVRYSQSSVSQSQDPKPPLPPRPPSATGRVSPQPGHTPAFGYQPQPSTQAQSQATSHPHGTSWGGPYLPGQATQGPTYPASAPVPPPPPPRPAAYEAEIQSFHNRVNTPQSEYSHRPPTHHYDPQQQNPWNTQNNPASVASYYPSAPAPHQAAGTNDGYLVSPIEASNTQWNQQAGSNAVQAIGSIQTSQPHVLGFGGPSDWEHYEPGMPPPEQTPTSPPPPAVGSPSQYSAPVSSPVGPAVPPAPQTPKPAPVHTPSPVEIGLASPVSRRGSHQQSPKYQVEWSQPSNTNRPSSASGHDAATSGRSDSLNSTGNIDSVIQAWTTPLRVKSGGEAFSRPESRISAASPEPSVDGRMTDPYADLAPEFKASLKRYATMLRKESAADSDEEKFEIFEAFVSKELRLRSLLYGVELSKPTKDVKKAANLVDIQAALPQSIQEPPNSARTASLDISAQPATTTTTTAAQPTVTRQPPPSDENKQSVLANVTVTSKPAASSLTHTGSEDDGEEAYSPGGRPKVGKASKATGPSPVSDSKSSASDNAVENEAYSPGGRPIITSLTKGSDKLSVSIPPQGKGRDHDSPGPISPSLNAPMVLEDYAMARPPSPGVNAPIIVQPEASRTSPSQPSAGQRPPSTPIKFEPPRPAYTPFRYSAATQAAPTKPFQPADQAYSSLRHSMVDSGRLLTQEASLIPPRPYSASGRKEHDEAFIGLIRNQSMAVRQKTPGPPDALKLGDNTVKSNTPVSRGLETSPLTRAQDPLKRAMIALRALVPEEGIVDSNSDPSVQDLKTKIEAVPDQFTFIHETVVEWDRTNRGVRRQQDAERRARQEESEAHIDALFNDNEIGYADIGDLEAEFKLAEAERRYRENQEELESFTAQVYTPVTERLQKEIQELNQAYATAMELLASNCEPVSRCLKARGGKAKMAEVMACVLTLFNKIEIRHRKLAEADVERERRRKHLELTVLYTNNDKDGMKKLEQEFAAAENAQVLHEARATDERANKLMDAFDRATVRGLGDNQMFIDDVLVKIQDLKQEITSRGQAVKEKLYEPSGARDTLSRIQDAVDLIMTDSRTLLALSNEADVLLNDADYGVSVAEARVSNAGKETYVNLAREKAKEDAKLVEEVNTRIGSVVKGPQHALDILRGMMDQIGADPEHQDRIKKALEAAKQRNAVNDPSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYL7</accession>
    <name>A0A0D1ZYL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1857 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_04957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237978.1">
        <property type="nucleotide sequence ID" value="XM_016379301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYL7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZYL7"/>
    <dbReference type="GeneID" id="27332040"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04957"/>
    <dbReference type="HOGENOM" id="CLU_111642_2_0_1"/>
    <dbReference type="OrthoDB" id="2320332at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015075">
        <property type="entry name" value="AtaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08982">
        <property type="entry name" value="AtaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW17762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18759" checksum="A7820272A19AFDFD" modified="2015-04-29" version="1">MSGTRSTPAPANYVAFSAPINPPGASPVLTYAQIWQGLLKKIRAAQDFVGAAIVSTDVISESTSEHGLPVTVREVVFREGGRRVQERCVAFEPMKVEFHQPDGSKVQNVISQDAGGNLYMTYTFEWLHYDLEGDDAALGAAREKEWKMAQLAVEKTIEVMREMAKDGRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZF7</accession>
    <name>A0A0D1ZZF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238283.1">
        <property type="nucleotide sequence ID" value="XM_016376713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZF7"/>
    <dbReference type="GeneID" id="27329437"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02354"/>
    <dbReference type="HOGENOM" id="CLU_1619029_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="164" mass="17827" checksum="825A8A6D0B7E1044" modified="2015-04-29" version="1">MADTPEGLTFIPPDTPLKKPELDTIGEVTAGRHNVDLGQARTADLDSDSDSDSDSDLESNDELTDDDDDAVLGKRNTGYGNKTFKDDEGSEIALQAITVTLSPDLSFAKMRDLRDRFVQKLQAVNISKASRLVNSKGDIIGRKGSVALKMAGIHLKPEISRYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZG0</accession>
    <name>A0A0D1ZZG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238293.1">
        <property type="nucleotide sequence ID" value="XM_016376723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZG0"/>
    <dbReference type="GeneID" id="27329447"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02364"/>
    <dbReference type="HOGENOM" id="CLU_062870_0_0_1"/>
    <dbReference type="OrthoDB" id="3360032at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022:SF1">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002248326" evidence="2">
        <location>
            <begin position="21"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="236" mass="26319" checksum="056B15021BE82554" modified="2015-04-29" version="1">MISASFIFLVVLTYSQTAYSNVEKVIFTSSLAEPYPTDASFANLLLVPLSEERPTVRTELDVSFPNSSARDGQVHWFFLEGLRPQQRYEVRICWPATQPTAFSLATFPVDAVLSDSSLLLSVSDYAYGRHEKLSAGDMESLQQRKTAVRPDTTILFLQILAAADYFSLNDTLMTAPPPVIVDIILDRYIWNVFPESLIPTALYLVLIAAFAWLFSGWMAKACTAPFIQLSAAKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3D3</accession>
    <name>A0A0D2A3D3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239618.1">
        <property type="nucleotide sequence ID" value="XM_016378048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3D3"/>
    <dbReference type="STRING" id="91928.A0A0D2A3D3"/>
    <dbReference type="GeneID" id="27330780"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03697"/>
    <dbReference type="HOGENOM" id="CLU_022380_0_0_1"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990431">
        <property type="term" value="P:priRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990432">
        <property type="term" value="P:siRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="610" mass="68717" checksum="C72AA7D038717435" modified="2015-04-29" version="1">MDITHATFSQELIKIIQHIAESRFVAFDLEFSGVAARRQGGASGKLSLQEYYHDLRSAAQIYQILQIGLTIVSEDTKKGRYVARPYNFHLSPLPAISENVFRRVWSYNSGAISFLLRHGFNMERPFSQGVHYLSRQEECEVREKLISDEKAKANMPNMVLKEEDSVLVDHIRQSINQWQSLPKETRESYLNIPTADAKDPIPSTLNRYQIRLTHQTVRNEWPKFKTQGMGHFVQITNPTAEQQESEKELREQMRERDIANAVGFRWLIEAITGGDISRLPHFYVSAGFPEGQVPEEIQGFLDKLQDSLRKRKGALVGHNCLTDLINLYRCFIGDLPDRVEDFSSKLHDLFPVILDTKYLAGIGGKRWADTSLQAVENDMSSTALPRITLPPGFDRYLHASNYHEAGFDSFVTAKLGLKLPAKLKREEKSLKALLQGPIETIEQEGSTQVRINQPDAAVQSENPGRGLTKGVVDVLKAPLTMASSILIGNDREKGQSSSNVPEDTSTLVASMMKDPPKMTHKFEDKKVASASQKSNIFEVLNDVPADTHVDEEDSVAQSAAAQRRIAEMVERGELLPPWDDDVQFWGLISNRLQANACEEGILDMLERQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AA00</accession>
    <name>A0A0D2AA00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241788.1">
        <property type="nucleotide sequence ID" value="XM_016376512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AA00"/>
    <dbReference type="STRING" id="91928.A0A0D2AA00"/>
    <dbReference type="GeneID" id="27329235"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02152"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="13"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW21572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="343" mass="36177" checksum="6152B642756437CA" modified="2015-04-29" version="1">MAPTNRAAFIPSKQSHPMQVGSAPYSSPGENEITIRTRAVAINPADHLLQKLGILITKYPAILGCDAAGDVVEVHPSLSSRFSTGDRVYGATAPLQNKDGLYAYSGFQEYVVMKMPSIAHIPARLDYKDAVVLPLGVWTAASCIFDENILGLAMPSAGREAGKGKTLIVWGASSSVGSCGVQMAALAGYDVVAVASAKNHDMVKSLGAKMAFDHNDATVVDDIVTFLKGKDVVGAYDAISKKATLDRVCEILDRCDATKKVVASVRPGAEQDATRGVKVTTNFASGKAEIGSAIWPWLERALEAGDMKCMPQPEVVGHGLEAVQTAVDLMGQGVSAKKLVLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASG2</accession>
    <name>A0A0D2ASG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_12101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847511">
        <property type="protein sequence ID" value="KIW09648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229864.1">
        <property type="nucleotide sequence ID" value="XM_016386408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASG2"/>
    <dbReference type="STRING" id="91928.A0A0D2ASG2"/>
    <dbReference type="GeneID" id="27339184"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12101"/>
    <dbReference type="HOGENOM" id="CLU_346822_0_0_1"/>
    <dbReference type="OrthoDB" id="4368043at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW09648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="814" mass="93782" checksum="8F94576BD95C21D0" modified="2015-04-29" version="1">MKAIFEGGVDPDQNRSNVCLHVESEEMGRIPCRVSYDIDGFIGFPLTLGALHNGFRWCPAQHMSLFIRSDLHIRRRVTFPGPGGEMLQRTLPLHHIPHLYLGSIDGLFQCALYVFFPRLTSPDRKFTFLPAETVQRFNERAMMPCFQDFIDHERLQRVPPTQQVAESKARARGLEQRQESHEKGLKTYLLSSLPSRGLSRAWEEIVARIDDETFGLTEFRDAFLLVDAKNLKADFKVAGSLYEAMDKYGTRLGQIFDFDLMDMMIHDIAREVYPVGITPNNRHVKHREVDATVLQWRTCCLRREHDRLRHKVFGGPAGRTSFYHPGFLRDTASMTIVPPRRSPARLGGWLYGQFYGVAKEIVDAGAVYPFSNERLLELAVDERVWLAHTKRKHGNTKQQQFFHDTYQESKRRVRRCYSDYADRSFANRVELRVQHGLFEGIKARAREDESSDRYSAILEESPSNTWAIGALQWSNFMLENYNKFTAALEMVAITSPRTGIPFERSKLIATLLRCVQRFSSCEPSRDAVLWYTTETAARGRVRGLGFKDTMARRGYGWFSPIIDWQHLSFAPEIASEVVRVSRDLSSWYMGSGRLLQDAHAALGLCLAFMTTSRVSQAHDEAMLLSVHICLREYRRDVLTAMKKELVQWDEADFDLDLVQFCHAGIQAALATEPHLVSGNKSKTSTPADLVEWLWGDSIKYNRKSFALKAFRIMRQKVEDALKEDWRPTWNQWTDLLQAEFLRHHWLIPYPDINGTLISTAKHTRARQWWSVIRPSGGTQWIWGRSKFTPGFPPPYPSTLSMDVSEITMLLQKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT21</accession>
    <name>A0A0D2AT21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_11974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230089.1">
        <property type="nucleotide sequence ID" value="XM_016386281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT21"/>
    <dbReference type="STRING" id="91928.A0A0D2AT21"/>
    <dbReference type="GeneID" id="27339057"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11974"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW09873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="443" mass="50278" checksum="62DF6569F21E3E14" modified="2015-04-29" version="1">MNRVRWQHRMLQEYGSPVRVGINELYFSDMKSWQDIYGQSSNPCPKEKVFYDMFTATGAVSLLNERNKAAHARLRRLVSHAFSLNALLQDEPMIHQKVKTLLEIVFIPTAEKNQPVDIFSKFMDHYLDITTYLSFGKSFDCVSGQGTLNHDDLDSFMVVVPTQAFFPQLRYVPMKAIQDGYRGLNRLIKFAEESVTEFHAKIEKNGDDYAKGTFLRNLVEAVDPETGSKLSFTELVENTILFLVAGSDTTAVTTIYTIWEIGKRPEVRKKLTDEIRTRFADPGHEPTYAETTELEYLNACIQETLRLWGPLSAGFPRVSPGKVIGDHFIPSGVQVATPAYATARDPAVFPNPTEYIPERWLNATPEMKNMSRPFSYGPRNCIGKHLADIGLQLTLARLYQLYDIEIDPSMTDTMMRQKDRGVCAPWDEKLVVRPSFVHPGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUL3</accession>
    <name>A0A0D2AUL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230634.1">
        <property type="nucleotide sequence ID" value="XM_016385690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUL3"/>
    <dbReference type="STRING" id="91928.A0A0D2AUL3"/>
    <dbReference type="GeneID" id="27338464"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11381"/>
    <dbReference type="HOGENOM" id="CLU_031477_2_0_1"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44253" checksum="E8F1D48E4DD4F967" modified="2015-04-29" version="1">MSYQYPIPATPRVISPSPTPSEASDRQDSYFAPVTRSAAKAQRQRSPQPEPIHEEKDGSGSDSSVEKRARTRSRSPILSAAVHMNGASSTGSKKRRMSGLPTKTPVKKSEPLTNGTIPVPQPNGHLSPYDRVKKSWREFSRSPSPLGLIPLHRHYRNLIHKHEIPRKLLHVSIGFFTLRFYVTGIQTTSITPWLLGALAIIAPTDVLRHHSERFNRFYIRVLGALMREAEVDGYNGVIWYLFGAYVALKFSPKDIGVVSILLLSWCDTAASTIGRLYGRYTIRLRRGKSLAGSLAAFLTGAIVAVFFWGYLAPRTGPFPDDPVEGFMFKDRLSLPNGVKELLGWQPSQGVIVGNAALAVMSVCTGIIASLSELVDLWGWDDNLTIPLLSSAGLWAFLKVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUN9</accession>
    <name>A0A0D2AUN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_11181</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230436.1">
        <property type="nucleotide sequence ID" value="XM_016385492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUN9"/>
    <dbReference type="STRING" id="91928.A0A0D2AUN9"/>
    <dbReference type="GeneID" id="27338264"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11181"/>
    <dbReference type="HOGENOM" id="CLU_031986_1_0_1"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="114"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW10220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="422" mass="44018" checksum="E0FA2FD5098E63FB" modified="2015-04-29" version="1">MGTTLDALNTAPSSLTQRRQAASNLPAFELPPPPISFAPGPLQKFPPLSGINTSHAGPAPVSVGQLLTPPSNPASESASSSAIQTGTTPNSGAAPVLPYAPSFFGGGTGTTPNAYHTGYTPQPWQNNGPLLPARSMFSPIQGQSLRSGTHSPSAGEASALPPPPYDLNPPYGAHLPLSSPGSTSLPAAAHHLVPSLQSGIRPPSQHSPISPNDNKPALFGSMTTTSQHQPSYVYSHPTTVSQAPRISPTLQQGALPSHSQAPFMRPPPPSYSLPAMPGPIMSNVHSPGTHMSMVGSMQPNMLPLSFNSGYAANPQAMYGQPRTNTPQQSPAHDRPFKCDQCPQSFNRNHDLKRHKRIHLAVKPFPCKHCDKSFSRKDALKRHILVKGCGSGSSAEAASKEDGTKSESGSDGVNDSPAAATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AW67</accession>
    <name>A0A0D2AW67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHRD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230951.1">
        <property type="nucleotide sequence ID" value="XM_016384349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AW67"/>
    <dbReference type="GeneID" id="27337117"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10034"/>
    <dbReference type="HOGENOM" id="CLU_063722_1_1_1"/>
    <dbReference type="OrthoDB" id="3554264at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010895">
        <property type="entry name" value="CHRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07452">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00754">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238657" description="CHRD domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CHRD" evidence="2">
        <location>
            <begin position="42"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="189" mass="19586" checksum="9416813AE513361F" modified="2015-04-29" version="1">MKAFTYASALLVALPALANASPVGAGGGGWAGWKDSPFHFTSTYNVIATPDQVINGTKSTPGEPGAKGYYNYGINSQLETICYNITLVGVTGDYRSPALTATHIHEAAEGSSGPPRIVFPNPLPISDDPSVVRRSVGCLVGPFKTGILSNGVDTGAGFTLAKLEANPAGFFTDSHTKKYVPGVVRGQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWW2</accession>
    <name>A0A0D2AWW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231409.1">
        <property type="nucleotide sequence ID" value="XM_016384807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AWW2"/>
    <dbReference type="GeneID" id="27337576"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10493"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_4_1"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF11">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="58843" checksum="4E2186257FCE9C06" modified="2015-04-29" version="1">MSDAQEVTIDDVELEAQGYEREMPRQFSLFSLMALSYALLATWNGFGSAMGIGLNEAGAAGTIYSLIIAAVLTGTIAVGMAELASAYPTAGAQYYWSFMVSSPEWAPFASYLSASVSTLGWWLGLGSVCQFIAAMILGMVKLCHDDYVVEDWHTWLCYVGVIWTACTLVIVGSRILPAFNSFMMYFSFVALIATFVTILACAAPNYQSGAWVFSTTTNATGWKSDGFAFVLAILNALYGFLGVDSGAHMCEEIPNPTVNVPKVIVYPVIIGFVSTLPFSIGCMYVITDLDAVLNTDTGLPLMELYYQATGSKAATVVLMSAFAVCMFGAACANITSSSRQMWAASRDNCYPFSKYWKQIHPKWHMPRNVVCLTGTLVSLYGLIFLGSSTVFSSMVGACIVFMTTSYVIPQGILAWRGRKKILPERPLNLGGWGLPVNVLACAWVVGIDVLFCFPPVMPVTKNNMNWISVVTVGLCSYIFIAWHVSQKKVFKGPRVDLPRLRRLREETRRHKTVVSIEGASIDEVPVERSPGKVSGTKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZZ3</accession>
    <name>A0A0D2AZZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232514.1">
        <property type="nucleotide sequence ID" value="XM_016383891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZZ3"/>
    <dbReference type="GeneID" id="27336658"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09575"/>
    <dbReference type="HOGENOM" id="CLU_396394_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="695" mass="76497" checksum="DE33140CB54BE251" modified="2015-04-29" version="1">MSAVTATEAHDAADKRAFNQAEAFTTSLAHVLRSVLRLVIAMPQPPYILSLLSLNLLCESIRVNSSVIAYFKDLGNLSNTFSQCAYSDKTYGPRRVLGAVETLLPEKKTIDLGDWSLETHGTSNFPRKAAAEVLSAIPGSQGFCLWPDGSLEVIMLPGRLVEWYRKPCLPCLAGIRIRLSQLQIAGPDDDRDTAAAERTRRLLIHRLSGPTATAATRPKKLGEVKSHRATPKRYRILRSPNIRKWRFRNKVNHLCKQIELSKKAPSHPILESESRPGITGVAFSSPRTLEIDTQPLREELTRGREISQLQRPKYRDATVKVVRSSENSRHNGGGSQTHISAAESEAEPVPAPAAPELNGAAGAKRTDSGTQEANGFVQGPRMGAISLASTPPEDVPLPPTPPPAESPEDAVEPSPSQEVMATRWIASPCNIRIGTSISTAGVKVRQANSTEQFVTISTHAAYEGCCKKPLPYCKPKSRKIFSRNANKPLPNLVGVLVQDASRQDVEVGKIFENTDVTFAADDSLVFPNEFPNNVSLVGPLSSTTRLAHRAGLVWSERINPDGVSLRILGDNEQAESFAVGTYFDSPLPVKHGKEKLELSARDIHRSLLYRRNGKPPQDAGKFRGAPVVLRDAEGKYKEVIGFEGFHFKPMHAQHENLRMDSKDVMQRIITGHVTTIYGAIKLTREFKRIWQIVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1A6</accession>
    <name>A0A0D2B1A6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232919.1">
        <property type="nucleotide sequence ID" value="XM_016384296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1A6"/>
    <dbReference type="STRING" id="91928.A0A0D2B1A6"/>
    <dbReference type="GeneID" id="27337064"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09981"/>
    <dbReference type="HOGENOM" id="CLU_014813_3_1_1"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="587" mass="63394" checksum="97B87CB99531DE04" modified="2015-04-29" version="1">MPHFQRFPSRRSVVYSKAGMVACTQPLAVEAGQRVLAIGGNAADAAVAAAAALAVTEPASTGIGGDMFALFFDARTRRVHAINGSGRSPRNSTLSRVRGDLNIPQGMLGRIPMRSAHAVTVPGAAAGWIDSVGSFGSNKLSMKNILGPAIQLCEEGFPVSDISSWLWKDAEDNLKSSHTDNSAVLKYDHSLSQLRAPKPGEVVFSPELSKTFQILVAEGKEGFYAGPIAEAIVKAVQSGGGYLELSDLTEHLRTSSEFTTPISGMFRGQRAFKQNMAFPEIWEHAPNGQGIVVLIALSLLEEFEKAGRIPQFRPEDHNTTPYLHALIESLSIAFADAHRWVSDPSHARVDARTLLSKSYLTERAKLFDPTKAGSHSYGRPLFSPIIESCDTVYLAVTDREGNAMSMVNSLYGHFGSCIVPTGYGFALQARGAAFHLGPENHPNVYQGGKRPFHTIIPAIITRSQGVRRDLAAVLGVMGGTMQPQGQLQVFMNLEVFMMNAQEALDAPRFCVDGEGADRVVFLEEGVSASVEEELTKMGHNIQRLGNWNRSTFGRGQVVKRQFDNLGGMPIYSAGSDPRGDGCAMPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1Q8</accession>
    <name>A0A0D2B1Q8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_09822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232761.1">
        <property type="nucleotide sequence ID" value="XM_016384138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1Q8"/>
    <dbReference type="GeneID" id="27336905"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09822"/>
    <dbReference type="HOGENOM" id="CLU_004495_0_3_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW12545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="59504" checksum="EEE5052F14A30E78" modified="2015-04-29" version="1">MADTEATGTVARSLSKDEGRLRELGYKQELKRDWTLMHNFGVSFSIISVITGITTLFEYGLTTGGPAVMSSGWLVVSFFTAFVGLGMAEIVSAIPSAGGPYFWAAILAPKKWAPFASWVTGWFNLLGQVAVTTGITFGCAGLISTLATVNGYEASAGKTLGIYAALLCSHGLVNSFGVHILRYLNNASIVLHSLGVFSFAVAVVAKAPHHQSAHFVFAKFYDGTGDPGWSVRASPEYVACIGILMSQYTITGFDASAHLSEETQNASWSAPWGVLMSIGCSAVFGWFLLLCLLFSIQDFDHTVDSDYGQPVLQILVDIFGKNGAIVLFTLVIVCVWHCGLFSLTSNSRMMFSFARDGGIPHFFHNVDARFKSPIRTIWLAAFLAFLLAIPSVGSSVAFAAATSIATIGLYISYGLPILIGMVNPQGFIHGPFNLRWFSRPVALIACGWIAFITIIFCLPELNPVDSQTLNYTPVAVGIIGFWCLASWFLWAHKWFKGPIRQIEAEVSGINVDDPAAMAEAEREGRIPEIEALESNKEASMLAAMKHNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2H2</accession>
    <name>A0A0D2B2H2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233319.1">
        <property type="nucleotide sequence ID" value="XM_016382616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2H2"/>
    <dbReference type="STRING" id="91928.A0A0D2B2H2"/>
    <dbReference type="GeneID" id="27335373"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08290"/>
    <dbReference type="HOGENOM" id="CLU_011409_2_2_1"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW13103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="58391" checksum="BC2A2EABA4B61392" modified="2015-04-29" version="1">MLTCLAGKRCTSTGRKCDGYEFPKETPGRSSSSSTSSPPSRSYPVAQYLFQPDSISKPVPGNTQERRIFHRFQYCTVPLLTGGSEAGFWSKLVLKVGLEETVVRNAIIALGTLHEDYQERSGRYSPQLIEDNSYRHALSLYGGALRQLNQRLNEPSKLNAKLAIVASILFACFEVLRRNNMAAVIHYQQGMRELFRQMNLPESDDTSLVASDKQATFREIPENEIDELLRVFARYDIQACTFSKERAEPLSTHITLPRVLPTDMTLSQVRYHLDNLLVSVYQLIKSDVRMYRYWDADSVPLEWRTRTQEAITTFDTWMAALEDFFTSNSHQLTNSDIKSLLGMRLQIKTAVIMLKVCIDCGPESVFDNFTDDFEDMVSKVEQMTAALGIQEAKPLEMELTPFTMELGIVHPLFFVACKCRDWDLRRRAIMQLKRAGKEGVWEGPIMAVLASRIMELEEEGLSFGEAVPETQRLHDIKKNVDYDNRQIFMEATKALDTTWNNFTILREVVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2I4</accession>
    <name>A0A0D2B2I4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233339.1">
        <property type="nucleotide sequence ID" value="XM_016382636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2I4"/>
    <dbReference type="STRING" id="91928.A0A0D2B2I4"/>
    <dbReference type="GeneID" id="27335393"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08310"/>
    <dbReference type="HOGENOM" id="CLU_031077_2_0_1"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="37209" checksum="66A45B66D696C222" modified="2015-04-29" version="1">MSSFFFSTPVDIDIVLDNADDRQTVDVKLDKNRREKAPLYLDGESVKGAVTIRPKDGKRLEHTGIKVQFVGLIEMFFDRGNHYEFLSLGQELAAPGELQHPQTFPFNFKNVEKQYESYNGINVKLRYFIRVTVSRRMADVIREKDIWVYTYRIPPETNSSIKMDVGIEDCLHIEFEYSKSKYHLKDVIVGRIYFLLVRLKIKHMELSIIRRETTGVAPNQYNESETLVRFEIMDGSPSRGETIPIRLFLGGFDLTPTFRDVNKKFSTRYYLSLVLIDEDARRYFKQSEIVLYRQAPELAPQLALDNPTIGGKLPDPAPPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2L4</accession>
    <name>A0A0D2B2L4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233379.1">
        <property type="nucleotide sequence ID" value="XM_016382676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2L4"/>
    <dbReference type="STRING" id="91928.A0A0D2B2L4"/>
    <dbReference type="GeneID" id="27335433"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08350"/>
    <dbReference type="HOGENOM" id="CLU_007774_0_0_1"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="78"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="910"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="549"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="822"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="937" mass="105454" checksum="E26E3F9FD1E1EA89" modified="2015-04-29" version="1">MTSMARPQTRETNRPVTREQIVDNTMVPSRTSSLHSRITQPLPSTLAKSNNRPTPKTLTHAYMVCGVGREPSQWVKAPAPSFGKIQHMKGAVGQFWLPEILGSSPRLESDNEIARALHSAMRACFPHDVEICTGRSQPHCVHHSFVLQQDSQHTLYGIALRVWSRADEKRAETIRDLRRKTEPDFRDVADETYWIPYCLSFLSRYPLYNLLGDYLRGMWIHWNKATNLFHAEEVSRILSFPAPRLNDLVRIDMKDYALCYQFPSSPTGFQNFAMWPLFSCLTIPNVVGLIEAAVSPTRRIILTSHHPAMLTIAAETIRFCVRVYEWSGLYVPVVHARNVSEMVQEPGPYILGITTECRSLFQPPKDALLVDLDRNLVITDHPPNVLTAGQRTKFINRLTQALNSDVEITGVPQHLKSAYGGGKLIPAGQIIVLRGEVESVQDPSWWNQDAIMAVMDHVCEKLGRNTGVKALFNGSMKKPLMTKISMRHMNEIVRERNQYSRDALEAWQDFINLKGRMDTELAKVAKRNNYLEQEVETWKLQFQKFQAFVESLNKELAELRVKIESHKRENRRLTGLIDQQKDDAARLTLRLSGTERQRDNALEALVLQQGIAEDLEKERSRNRKEIAALQHTNQTLQRQRDEAQRVVLHLRSLITGQTHHMEHIVRSIGSASELADYIHEGYEDEEEDYEENEAEDTVEELSDKLRNVTSRSSKRASRVVSADGQDVTPQMENKLLASSKRLSKRFSGLSMSDVADRHLRDKTDAIADIIRNISEQCAAAVEGLQLANEAAEVEGEEEDQDQGEHSESGISPSVSHSREDSGNLSPVEQLATDSRTGTGHLTPQSERSSIPPTPDLVHQRSSTALSMASTAPTNYTARESLNQHTRGLDRTKIVEDEDAERAHAAAVIGGGSLKGDDENIKQPASGRGAVLSRVIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6G2</accession>
    <name>A0A0D2B6G2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234501.1">
        <property type="nucleotide sequence ID" value="XM_016381399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6G2"/>
    <dbReference type="STRING" id="91928.A0A0D2B6G2"/>
    <dbReference type="GeneID" id="27334150"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07067"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF13">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="260" mass="28011" checksum="8D9A01961E2D4C4B" modified="2015-04-29" version="1">MTVKVALVTASSAGLGAAAAKGLARAGFDIVVNYNSNKTKADAIVTDILRTNSNDNSCACATEDPPRKALAVQADMSRREDIDRLVDTVVTTFGRLDCVVSNQGWTRMRQFDNLDDNIDEGDWDICYNMNVKSHLYLFHAARPHLAKVKGSFTSVASLAGVIPSGSSIPYSVTKAAQIHLIKALSKVAAPEVRVNSVSPGILLTDWGKKFPETKVEAAIQKSTLKRLAEIDDVVQQIVLFATKQSYTGQNVVIDAGWSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6P6</accession>
    <name>A0A0D2B6P6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RecQ-like DNA helicase BLM</fullName>
            <ecNumber evidence="17">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PV08_07322</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="17"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234754.1">
        <property type="nucleotide sequence ID" value="XM_016381652.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2B6P6"/>
    <dbReference type="GeneID" id="27334405"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07322"/>
    <dbReference type="HOGENOM" id="CLU_001103_16_4_1"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000537">
        <property type="entry name" value="Bloom syndrome RecQ-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="760"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="968"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="39"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="135"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="628"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1276"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1341"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1455"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1302"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1456"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1472"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1500"/>
            <end position="1513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KIW14538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1513" mass="170575" checksum="AF7547158DAE1D47" modified="2015-04-29" version="1">MTNNNLSHCLAWLLQHPHSFDHLDHISVVANTAVAQYDEPQDTSNDEMARLQFPPQPQPRSKLILQPSQSNALPTPDPSRASEERKPSPRRVRRTFETPSARLLSSRPRTPVGTFEETKDVLDIDEIDLTEEITSSSFGEFGPPTRLWKESSASRVEPPSKKKGRKRKSDEYRSDLLSPSSNRNPSKRVQKALKSCAISQSGSSPRRPFDKENNLQRGTPSRPHASTIPAAVEEEEDEFPDAGFSEDLQFYDAIDDDLNEAPAQPPQPGLRHERPCEEVADSDGDDQDFVPLNRQRHAFLDTPSIKDQQESSHLSYSVEPTRGIPRSSQPHVSLKVSQTSPRSFLQTSKCESSQQSKSKPETAFKSSGSSVGQNKDLTEDETRIINSFVKSGATLCQSLLERLQQSHRSVKRAILDEICDNGGPPSREKQDTLKDIEYKISATGQLLDEHGILKKALDQQNELMKQRYDLEEANHLIDFDDPTDALMQICNNIRRIKLDIDTRQHLILNLLEKAGVSMTSEPGPLPTSHGARLSPQRALAGKSVLVASTQKAARYISPLKTYENAQDLAHLSTQSIRQTPVSQRAVIIDNSCESRHQNHPQSRSPQPSILLPKVTQHPAMLKTVPRVPESPRQVQATSYEDAEEFDQGYSRTMASPDPDHAVSDDEFGCDFSDEELYKVAEEFDQNLPTARSVSPSCRGRMALGEVSENIRRVSPQKGTIRNDNVPHANLMQHPWSKDVASALKKRFHLHGFRHNQLEAINATLSGKDAFVLMPTGGGKSLCYQLPSVVQSGRTRGVTVVVSPLLSLMQDQVDHLNKLRIQAVLVNGDSTKEARNYLLTTLKGPHPERFVQLLYITPEMFNKSQAMVRTLQDLHQRRKLARIVIDEAHCVSQWGHDFRPDYKALGEIRKQFQTVPVMALTATATENVKIDVMHNLGMEHAEVFTQSFNRPNLTYEVRPKGKGQAVLDGIAQIIDTSYKGQAGIVYCLSRKNCEAVAEQLRHSYGINAQHYHAGMSSEERIDIQKKWQAGTFLVIVATIAFGMGIDKPDVRFVIHHTIPKSLEGYYQETGRAGRDGKKSGCYLYYGYGDTTSLRRMIDQSDGSWEQKERQKQLLRNVVQFCENRSDCRRKQVLNYFNEHFDPAECKNGCDNCTSTSTFVTEDFSEHARHIVSLVNRVHRDNVTILHCVDVYRGAKLKKITELQHDQLDEFGLGSELIRGDVERIFNRLIWEDALEPFNQTNRSGFTTEYIRPGRNARVFADGRRPLKIQVLASPRNKVQAKISKSRKKPKGTGVTAAADDYPASTNVSSPVQPRSRSKLVQRGGMEESDDDFIVQSSEEASISANRRAKRTANADSRSAPITTDDDISALNEIHQHILEDFVERAKKDVQRIMIAKSMRRKPVTDRMLRQIGLNFPQNEQQLRQLTGLNPEMYQVFGPLLLRLSTTSFNNYEAMMRAQEDRPDDPNHQTVVEISDDDMDGDDDFNPSDFDMGEAESSHYFGRRDEVSQFNERSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7E2</accession>
    <name>A0A0D2B7E2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_07364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234796.1">
        <property type="nucleotide sequence ID" value="XM_016381694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7E2"/>
    <dbReference type="GeneID" id="27334447"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07364"/>
    <dbReference type="HOGENOM" id="CLU_012970_2_1_1"/>
    <dbReference type="OrthoDB" id="4088837at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="65601" checksum="AF5D0D3AA4E11547" modified="2015-04-29" version="1">MSFSDESQTTKGKTTTILPEDPKNPFHDNNTTSDAGPNKEVPPPGGEGGARRDSILLVGDKSPGVARIEAIGEVLTLTDRIFLFIGVFLVAYAYGLDGTVRYTFQTTATADMGEHSLLATINVLRAVIAAAAQPTGAKIADVFGRLELVCVSVFFYTLGTIVEAVATNVSTFAGGSVLYQIGYTLIILLVEVIIADITSLRARLFFSYIPALPFIINTWVSGDITEAVLASTTWKWGIGMWCIIYPVCALPLIITLFIVGRRARKAGVLDKYQSPFQQLGARKLTVSLFWSLDVVGIILLIAVFALILVPLTIAGGVSSKWREAHVIAPLVIGILCIPAFIFWELWAPHPLVPFDLLTDRAVWGALGIACTLNFAWYMQGDYLYTVLSVAFDFSVKAATRVSSLYSFTSVITGFVLGMIVYKVRRLKWFIVAGTCLFMVAFGLLIHYRGSPSSSGKSGVIGAQVLLGFAGGLFPYPAQASIQAATKHEHVAVITGLYLATYNIGSAFGGCVSGAIWTNVLPSTLEDRLAPLGNSTLAASTYANPFGVIAEYPVGTPERTAIIAAYQHAQRLLCITGICLAVLLIGFSLCLRNPKLGNEQSLPDAEENVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8G6</accession>
    <name>A0A0D2B8G6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235449.1">
        <property type="nucleotide sequence ID" value="XM_016379622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8G6"/>
    <dbReference type="STRING" id="91928.A0A0D2B8G6"/>
    <dbReference type="GeneID" id="27332361"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05278"/>
    <dbReference type="HOGENOM" id="CLU_2003946_0_0_1"/>
    <dbReference type="OrthoDB" id="4158382at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="124" mass="14908" checksum="725B60B9C7D75345" modified="2015-04-29" version="1">MDDNGDSERSYDCSDADHYYELKEERDEMEQENLRERKEKGRQRDIEKTEEEEVRVAYRSLNKAEKERKTIPARSLTGQRFRLFCGDHVDLFYSSFYVTKRVDFYHLDNTETPSPLAISRRELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8K3</accession>
    <name>A0A0D2B8K3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235201.1">
        <property type="nucleotide sequence ID" value="XM_016382099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8K3"/>
    <dbReference type="GeneID" id="27334855"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07772"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="54"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="542" mass="60051" checksum="5F8B4780FBE9F7D4" modified="2015-04-29" version="1">MAAHNSRDVVPGTIHLVDTDAADHSHRHDIVLNPRPSSDPEDPLNWSKTRKAIAITMAYIYILGIGMSTTVQYSILTNIGEETNISIGDINTGTGLMFLFAGWGCLIWQPIALTYGRRGVYILSSLIALGPMVWTVYTSSRSIWWAHRSLLGLIVAPVESLGEISVSDLFFAHERGNYMGIYTLLVFGSNAFAPFLAGFITDAMGWEAAIWFGTIVLGVCLVIIFFGLEETMYFRHTIEGVDEGAAVEVIKGTENLDEKSAALSTNAPIPQTASPPAEVSYSQKRTYLQKLQLFRLDTGRPSVKQMFIMMIRPLFMFFYFPNVVWAGFLYGASLCWYNVQNATMALILNAPPYNFSAQSVGISYLSLLIGCIVAWWWAGWAGDEIAIRLARRNRGIREPEHRLWLLLFSGTLATAGLILWGVGAAHQTHFMGLIIGLGMTSFGIVSGGSTALAYDVDCFKEIAGESVVLVIVIRNTMGFAMSYGITPWLVNTGTQNCFIAVAFLCLFCNFSFLFMTVWGKRLRRLSAKKYWEYVDTLIVAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAE7</accession>
    <name>A0A0D2BAE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylisocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235741.1">
        <property type="nucleotide sequence ID" value="XM_016379914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAE7"/>
    <dbReference type="STRING" id="91928.A0A0D2BAE7"/>
    <dbReference type="GeneID" id="27332654"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05571"/>
    <dbReference type="HOGENOM" id="CLU_027389_3_0_1"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF2">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="32853" checksum="2DDF672EFDFBE136" modified="2015-04-29" version="1">MASSTKIPLRPSPATQRLRDLLADPEHIVVAPGVYEGISARIALSLGFEALYMTGAGTSMSRLGYADLGLTTQHDMVSQAETIANISPSTPLIADADTGYGGPVAIARTVSKYARAGVAALHIEDQVQEKRCGHLLGKEIVAREVFYSRIRAAVNARRDLGLDILIVARTDSRQSYGFEEARNRLLRAAEIGADVVFPEALTSTSELAEMVRAMRRTPCLLNMVTKGVTPELSVDQAKELGFRIVIFPIAGFGGAIKGITESLATLKSTGREPEDLIGVKQAFELCGLNECIELDKRAGGKALAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAR5</accession>
    <name>A0A0D2BAR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L10-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235901.1">
        <property type="nucleotide sequence ID" value="XM_016380074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAR5"/>
    <dbReference type="STRING" id="91928.A0A0D2BAR5"/>
    <dbReference type="GeneID" id="27332818"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05735"/>
    <dbReference type="HOGENOM" id="CLU_084051_0_0_1"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="223" mass="25647" checksum="10B96809BBA0B274" modified="2015-04-29" version="1">MARRPARCYRYCKNKPYPKSRFNRGVPDPKIRIFDLGRKRANVDEFPLCVHMVSNEYEQLSSEALEAARICANKYLVKIAGKEGFHMRVRAHPFHVVRINKMLSCAGADRLQTGMRGAWGKPQGTVARVNIGQILLSVRTRDAHRATAIEALRRSMYKFPGRQKIIVSKNWGFTPLRREEYIKLKQEGRLLQDGAYVQFHRSRGAIEQNIKRFPGAYEVASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BB20</accession>
    <name>A0A0D2BB20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_05860</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236026.1">
        <property type="nucleotide sequence ID" value="XM_016380199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BB20"/>
    <dbReference type="STRING" id="91928.A0A0D2BB20"/>
    <dbReference type="GeneID" id="27332943"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05860"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000706">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="4"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW15810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="328" mass="36958" checksum="A33A80492BCFC718" modified="2015-04-29" version="1">MENYQKIEKIGEGTYGVVYKARDLSNGGRIVALKKIRLEAEDEGVPSTAIREISLLKEMNDPNIVRLFNIVHADGHKLYLVFEFLDCDLKKYMEALPVSDGGRGKALPEGSTMDMQRLGLGKDMVKKFMAQLVEGVRYCHSHRILHRDLKPQNLLIDREGNLKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGGRQYSTGVDMWSVGAIFAEMCTRKPLFPGDSEIDEIFKIFKLLGTPDENTWPGITSFPDFKTSFPKWRREPTSKFVPNLEPAGLELLDAMLEYDPAHRISAKAACNHPYFAAGSAAYSQRTNGVSRLNGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBB9</accession>
    <name>A0A0D2BBB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_05950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236116.1">
        <property type="nucleotide sequence ID" value="XM_016380289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBB9"/>
    <dbReference type="STRING" id="91928.A0A0D2BBB9"/>
    <dbReference type="GeneID" id="27333033"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05950"/>
    <dbReference type="HOGENOM" id="CLU_025694_2_0_1"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238946" description="Mannan endo-1,6-alpha-mannosidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW15900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="440" mass="48503" checksum="1B47AF44C0F8D5F5" modified="2015-04-29" version="1">MVMSLPLLLMMRILSWLSCWQVVVVVVAAAAQHDGIPLNISDDSSIRHAASVAAYSLQSLYNGNRTGGTLGKFPYPPYYWWLSGAAWDGMLHYWLFTGDESYNNVTWTALVSQISPTNNYLPVAEMFDEGNDDIAFWAFAAMFAAEHSFPDPPSPRYPSWLGICENVFNDFVTRWDKASDTCAGGLRWQVFPSSAGWDYKNSVSNGGFFQLAARLARYTGNETYLLWAERVWDWSERIGLVDAADLSVYDGAGIDGGLNCTRLDHTQWSYNIAVYLYGAAVMHNITVPAGTGAWQRRGVWTNRTEGLLSRAERVFFGDTYGGGSLTNASGIMVEQACELDWSCNVDQFSFKAYLARWMADTTVLAPQLKGRVGGMLKSSAKAAVKACTGVDAGEARVKCGAHWYLGEWDGSIGVGQSLSVLEVVQSLLVNETEAPEFGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBC0</accession>
    <name>A0A0D2BBC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236524.1">
        <property type="nucleotide sequence ID" value="XM_016380697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBC0"/>
    <dbReference type="STRING" id="91928.A0A0D2BBC0"/>
    <dbReference type="GeneID" id="27333442"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06359"/>
    <dbReference type="HOGENOM" id="CLU_139299_2_0_1"/>
    <dbReference type="OrthoDB" id="5015991at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="123" mass="14907" checksum="FBA1CF44154D81CD" modified="2015-04-29" version="1">MCYYARTDFSCRDWKWGNMKQRCPRQHRMGETCGAKLVDPDNVINVQDQCRICKEIEVKQRRMQKELDNIARWRREGDKFRASIEKAQREARMLQETIDELHSRRASVRYQLRNEARLPTMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEA3</accession>
    <name>A0A0D2BEA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_12008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847503">
        <property type="protein sequence ID" value="KIW09724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229940.1">
        <property type="nucleotide sequence ID" value="XM_016386315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEA3"/>
    <dbReference type="STRING" id="91928.A0A0D2BEA3"/>
    <dbReference type="GeneID" id="27339091"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12008"/>
    <dbReference type="HOGENOM" id="CLU_061239_0_0_1"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="8">
        <location>
            <begin position="143"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW09724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="321" mass="34227" checksum="071D7E3540541240" modified="2015-04-29" version="1">MVTPTTFPKVISRSQSSKGRTRKAAQLDKNTIVRFDDLSEEGKKAALEKSHRYNTEQSVPSPSQKSNPTQSETPRHSRLQSLGDRRPYIMAFFGLGFIVLAVLASLALAVDKDKDPSLVAKLRLANTNLDRLKLLPKDEDWVFDFTKQDKYTFSPGGVINANAATFPATVGLGLTLAVLNLGPCAMLPPHLHPRGANFVVAISGTTQTYMINENGARTVQATLRSGQMTIFPEGSIHTMMNVGCDNAQLISALNSDDTGTLNVANSFFSLPQNISGTIMGGGVNVSDIEGKVPDPGTGANSGPHECLAVCAARANGTRGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGC8</accession>
    <name>A0A0D2BGC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238224.1">
        <property type="nucleotide sequence ID" value="XM_016376654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGC8"/>
    <dbReference type="STRING" id="91928.A0A0D2BGC8"/>
    <dbReference type="GeneID" id="27329378"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02295"/>
    <dbReference type="HOGENOM" id="CLU_022730_0_1_1"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="475" mass="53186" checksum="7C3EBEBDA73DFE65" modified="2015-04-29" version="1">MKPLQLPVPNPIPSVWTAQPHALDNHGSKATLPTECDIVIIGSGFSGVATAYHILKCYNNEPSIVLLEARELCSGATGRNGGHIKPDTYYSTTKYETLYGAQQASALQKFESSQVLAVKQLVETEALDCDFHLTRAVDVYLDRDHARKTYEAYLKLRQSGSYDLRDVAYTGKEDAERISGVKGAQCCFSFTAAHLWPKRLVLGLLERLLRRPNFQAHAHTPAYRVSKTQDEAGFWTISTSRGDLKARKIIYATNGYTASLLPQYRRKIVPVRGVCSHIKTSKGANSPHLPNTYSLRFGGANYDYLIPRADGSIVVGGARQTFLHDRDLWFDSVRDDERMSRASDNYFQGYMQRHFRGWEDSEASTDRVWTGVMGYTSDFMPHIGPVPDIPGQYVIAGFSGRGMAYILLASRALARMVVEGIDYEQTGLPTMFKSTRERLSASESELEKEFKGVWGSDQTTMQEDKRVPPLLQARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGJ0</accession>
    <name>A0A0D2BGJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2,2-dialkylglycine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238319.1">
        <property type="nucleotide sequence ID" value="XM_016376749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGJ0"/>
    <dbReference type="STRING" id="91928.A0A0D2BGJ0"/>
    <dbReference type="GeneID" id="27329473"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02390"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_1"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="50391" checksum="D381D2ECB2E5513C" modified="2015-04-29" version="1">MAPMIEDSVSHGTTTASSNPVGKPTLYSNVDEEGLQAAASNCLANYGTKFEKDIVVGSRGLYVYTANGHKVLDWTSGQMSCLIGHGHPEIVSTIHDHAESLDHLFSGMLSPPVINLAKRLTSVLPHGLDKAFFLSTGGESNEAAIKMAKVYTGKFEIVGLGASWHGVTAQALGTQYHYGRKGQGPMMPGMHMLPPPNAYRSIFRNPDGSYDWETELNYGWDLIDRASCGSLAACIVECIQSSAGMHVLPPGYLKALKKHCEKRGMLLIVDEAQTGVGRCGDLFAIDHEGVVPDILTLSKTLGNGLPLSAVVTSSEIERVCTERDYCFYTTHVNDPLPAAVGDKILEIVVRDGLVEHSRTLGLRLQAGLQKLKDRYGCVGDVRGRGLMAGLEIVGDRETKAPALELASRIADKMYQLGLWANLSSHSSFGGVFRIAPPIVLTEKQLDEGLEIMENAFRTTEGTMPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BH41</accession>
    <name>A0A0D2BH41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230885.1">
        <property type="nucleotide sequence ID" value="XM_016385941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BH41"/>
    <dbReference type="STRING" id="91928.A0A0D2BH41"/>
    <dbReference type="GeneID" id="27338716"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11633"/>
    <dbReference type="HOGENOM" id="CLU_012358_2_1_1"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01298">
        <property type="entry name" value="ATZ_TRZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="76"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="493" mass="52930" checksum="9E70D78BFF7CCB02" modified="2015-04-29" version="1">MPLLDSTIETTKSAAATLFTNATIITVDAERTIWLDGAILVNGDRIEAIGKTNSLLENPRSQSHSECKIVDCQGKIIIPGLINTHAHLGQSLLRGLAEDVPLHTWLCDSIWPLEANYEGEDGYVASRLTIAEMLKSGTTCFLEALLTHSSGFENAARAVDEMGIRGCLGKLVKVEGESTKFGMTDPRDRDISGMSITAALAAHERFHGTSNGRLQVWMAAGTPRGSDESSHKAIGDACSAHGIGLTMHCAEAPKDLTIYRESYGCSPVEFCSRTNLVSRDKKTVLAHMVNLDLDRDLPLLRAAGTTVAHNASSNCKLASGIAAVPEMLDAEVNVSLGTDGAPCANTYDMIQEMRVAALVHKGSRRDAAAITAEQVLAMATINGARALGLEKDIGSLEVGKKADFVVVDTSGLHCAPFDSRQVLEGGVDPVTVIVFSCSGADVDKVVVDGDLLVDSGDLVKFDERKIREDAQRAVRRIRNKTDTVQNRLKRKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHA9</accession>
    <name>A0A0D2BHA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02276</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW17990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238206.1">
        <property type="nucleotide sequence ID" value="XM_016376636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHA9"/>
    <dbReference type="GeneID" id="27329359"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02276"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="4113256at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW17990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="519" mass="56448" checksum="AC65226EC39B9C94" modified="2015-04-29" version="1">MVDERLSRAGFAGQHQFNWRNLRLCILVSMGALAFGYGISIIGTTLGEPGFSLYMGLVDSTTGEPTHNAAGLIGAITGTFYAGSCCGLLLSAFVMDRWGRKAGVIYAAVVSIVGTVGVTAAQNVAMFIVFRFVCGLGINAFLGVTGVLTSEIAPPALRGFFVGMVGGGILVGYSIASLMGLACFYIHSPSAQWRLPLGLGLVFQVFMLCVLPWLPESPRWLLMVGRDVEAKAIIYDIHKSSKDHSQTFAEREFYQMERQIELDKRLKASFVEMFTRPSYRKRTIIALSFGFFNQSTGILVVGSYGTLIYKSLGFGARDVLCFQAGWIMTGIPFNFLGAWLSDRWGRKPMFILGLAGCAFSLALEAGIVATYVTPEKLIYPNQAALGVAVAALYLMMAFFGLTLDVVGTPFINEVFPNHLRSKGYSLTLAIMTCTTLIYTEVGPTALAHVGWKFYLLFICCCVVGCFWIYFTFPETKGVPLEEIAALFGDADDVAVYSANIETGIEMGGKTDVVHLEMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHK9</accession>
    <name>A0A0D2BHK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231070.1">
        <property type="nucleotide sequence ID" value="XM_016384468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHK9"/>
    <dbReference type="STRING" id="91928.A0A0D2BHK9"/>
    <dbReference type="GeneID" id="27337236"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10153"/>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="253" mass="28415" checksum="EB8E1389131C4103" modified="2015-04-29" version="1">MTSHPPGKCCYKGVKHEGTATGEFSTLGDFEIYTKYPENKSTEKGILLITDVIGHRFINANLIADQFAANGYFVMMPDLFYKDPIPLNRPGDFDIAKWIKGEYNEAKIAHTPPVVDPIIDSCLVEMRTKYNCKKIGAVGYCFGGKYVVRHLRPEAGKIDAGYTAHPSFVDADELRDIKGPLAISAAETDQIFPTEKRHETEAILKEVGQPYQINLYSGVEHGFAVRGDPKNRRALYAKENAFLQAVQWFEEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHQ7</accession>
    <name>A0A0D2BHQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231125.1">
        <property type="nucleotide sequence ID" value="XM_016384523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHQ7"/>
    <dbReference type="STRING" id="91928.A0A0D2BHQ7"/>
    <dbReference type="GeneID" id="27337291"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10208"/>
    <dbReference type="HOGENOM" id="CLU_109163_1_0_1"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW10909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="149" mass="16908" checksum="600014FB3C762E23" modified="2015-04-29" version="1">MPTRLTKTRKHRGHVSAGHGRVGKHRKHPGGRGLAGGQHHHRTNMDKYHPGYFGKVGMRHFHLTRNQYWKPTINLDKLWALLPEETRDEYVSGKKTDTAPVLDLLPLGYSKVLGKGRIPEIPIVVRARWFSKEAERKIKEAGGVVELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BI33</accession>
    <name>A0A0D2BI33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_02902</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238829.1">
        <property type="nucleotide sequence ID" value="XM_016377259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BI33"/>
    <dbReference type="STRING" id="91928.A0A0D2BI33"/>
    <dbReference type="GeneID" id="27329985"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02902"/>
    <dbReference type="HOGENOM" id="CLU_009020_4_1_1"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="137"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW18613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="539" mass="58906" checksum="A9721BC51BFE992F" modified="2015-04-29" version="1">MTLDDEHSDGSVNGRTKGSLEIQIPLLLSSTDDNSDDNGDPSIASNQPGRPTPQRQSSLSHPRPDGTPRTTNRVRFDLIEGQNVQHPEEWMEEEDYLESPSNSQHAPLLTDITPPAQSPFLSDSFQPEDYLPDARPKSGMRSAFMNMANSIIGAGIIGQPYAFKQAGLTVGVILLIGLTITVDWTIRLIVINSKLSGADSFQATMQHCFGSSGLVAISVAQWAFAFGGMIAFCIIVGDTIPHVLEALIPGLRDLPFLWLLTDRRAIIILFILGISWPLSLYRDIAKLAKASTLALMSMLIIIVTVVTQGPFVDPDLRGSVSGMLFVNDGFFQAVGVISFAFVCHHNSLLIYGSLKTPTLDRFATVTHYSTFISLVACLVMALAGFLTFGDRTKGNVLNNFPSQGHILIQIARLCFGLNMLTTLPLECFVCREVMNNYWFPEEPYQPHRHLIFSSALVVSAMGVSLITCDLGAVFELIGATSACALAYILPPLCYIKLSTRSWRTIPAVLCMMFGVAVMTVSLILAMKKIIKNEGEPQQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BI72</accession>
    <name>A0A0D2BI72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_10333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231250.1">
        <property type="nucleotide sequence ID" value="XM_016384648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BI72"/>
    <dbReference type="STRING" id="91928.A0A0D2BI72"/>
    <dbReference type="GeneID" id="27337416"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10333"/>
    <dbReference type="HOGENOM" id="CLU_001485_27_3_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.320">
        <property type="entry name" value="Photosystem II 12 kDa extrinsic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF9">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="2 3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="5">
        <location>
            <begin position="2"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="398"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="555"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="555"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW11034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="730" mass="80820" checksum="39BA0BCF09F10C35" modified="2015-04-29" version="1">MSVRVVARIRPLLKSELEKDQIVTSHAATDDGPTIVKIPNPKNFAEEFSFQFNSVYEQESTQQELFEAEVAPTIKHLFLGYDVTIFAYGSTGTGKTHTMRGGKSLGDRGMIPRMLSNIYRKSRALEKSTNGDTKAAVSMSYYEIYNDRVYDLFEPPDKRTPTGLPIREAEGGKTVVVGLTEVPCGSLKDFEVLYDKANANRSTGATKLNAHSSRSHAILCVKLTVTSPTETRVSVASAIDLAGSEDNRRTGNGKDRMVESASINKSLFVLAQCVEAIAKKQPRIPYRESKMTRILSLGQNNGFTVMILNLAPVKAYHLDTLSSLNFANRTKKIEVREVENDPIFKGPPRQVSGASLGGPTIQRQPLRPLTNSINVNLIATKDAAGKNEKPPKAFSVYSDRYRPSIPKPVTQKSPPLKRTADTSFTGSTRPAKASRPTPSFIRRGPEPANLTKASIESLVEQKVSEILAARALNAPDPLPTKTISEEVQRRLDSIEKRLEGQEGERAEGLSYLFMAKQHQARGEDGSALKMYELARPYFPDNQKLESKIERLKEKMARKREEVEEPPHKPEESVARDARTEDRNGQHHDDDDDESYHDDGDAESAYNDSDADDNGSTSRRAGRWRKPTKPKRKRISSPDPLAQQDGSTAILTPRTRYLIDVLNSRDVARIKSLSGLGAKRAEGIVDFLNGDGNDDDGREGAGTTLHSWTDLTRLRGIGKKTLETMREGVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIX3</accession>
    <name>A0A0D2BIX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238716.1">
        <property type="nucleotide sequence ID" value="XM_016377146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIX3"/>
    <dbReference type="STRING" id="91928.A0A0D2BIX3"/>
    <dbReference type="GeneID" id="27329871"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02788"/>
    <dbReference type="HOGENOM" id="CLU_038964_1_0_1"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF294">
        <property type="entry name" value="POTENTIAL PROTEIN LYSINE METHYLTRANSFERASE SET6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="16"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="357" mass="39365" checksum="1A5A9E7A1DC66723" modified="2015-04-29" version="1">MSQSPRITQNARPSSGYFEVRSTATSGRGVFALTDIPAGTTLLETSLIAASTIYKPYAKEVCAQCFAYNRGIVWKVRDNARNVVFCSDSCQEVWRATTPAPALVAREEVQKFLQRRQKLWNAEIEDFNKPAADQIDGAWAAAEEKATLIRAALSSTMPTKAQIKALRQAQSLHPDPDTLWFLLDAVTQSLRQTGILDLTADLAADPQPYINAEDLGFHVDAYLAMLAVVPGDVVFPHVDRSLLRTIQSRTTHNSFGLRSLDEGGSADDATGTAGSECFGFGVWPEASYWNHSCAPNLKKQRTGRTWTFSTNRHIKAGEELCISYLGGDERDMTTAARKEKLRRIWGFECACEKCAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ30</accession>
    <name>A0A0D2BJ30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239134.1">
        <property type="nucleotide sequence ID" value="XM_016377564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ30"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ30"/>
    <dbReference type="GeneID" id="27330290"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03207"/>
    <dbReference type="HOGENOM" id="CLU_002865_5_1_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF119">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="572"/>
            <end position="573"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="667" mass="74278" checksum="481A55F5A04B32B2" modified="2015-04-29" version="1">MTVPDEVDIIVCGGGSSGCVPAGRLANLDHNLQVLLIEAGESNLNNPWVYRPGIYPKNMKLDSKTATFYYSRPSEWLDGRRAVVPCAHILGGGSSINFMMYTRASASDYDDFKMKGWTTKELIPLMKKHETYQRACNNRDIHGFEGPIKVSFGNYTYPIMQDFLRAAESLGFPVTDDLQDLTTGHGAEHWLKWINRDTGRRSDAAHAYIHATRAKYQNLHLQCNTKVDRVVIENGTAVGVLTVPTKPVGGRDIPRRFFKARKLVIVSCGTLSSPLVLQRSGIGDPEKLRKAGVKPIVDLPGVGLNFQDHYLTFATYRATPETESFDDFARGVPEVQKAVFDEWNLKGTGPLATNGIEAGVKSRPTEEELEEMKSWPTPDFSPGGWESYFKNKPDKPVMHYSVIAGWFGDHMDMPPGKFFTMFHFLEYPFSRGFTHITSPDPYDAPDFDAGFMNDKRDMAPMVWGYIQSRETARRMRAYAGEVTAMHPQFAYDSPARARDLDLATRNAYAGPNHLTANIQHGSWTAPLEAGKTTEPNWLNSNCQEDRSEKLKYRPEDVAHIEKWVQRHCETTWHSLGTCSMGPKNGNSVVKHGVLDERLNVHGVKNLKVSDLSVCPDNVGCNTFSTALLIGEKCAVLSAEDLGYSGAALDMKIPTYHAPGESVGLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJN1</accession>
    <name>A0A0D2BJN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239021.1">
        <property type="nucleotide sequence ID" value="XM_016377451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJN1"/>
    <dbReference type="STRING" id="91928.A0A0D2BJN1"/>
    <dbReference type="GeneID" id="27330177"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03094"/>
    <dbReference type="HOGENOM" id="CLU_009397_8_0_1"/>
    <dbReference type="OrthoDB" id="3879658at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF5">
        <property type="entry name" value="ENDO-ARABINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239064" evidence="7">
        <location>
            <begin position="26"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="365" mass="40114" checksum="7584C62860961765" modified="2015-04-29" version="1">MLGTPRTAWVAFCLTTATLFQSAPAADVHGAAISTNFPDPGLAQAEDGIWYAFSTQNENINIQLASSTDFVHWTLHEGYDALPRLPAWARKPPYAHVWAPDVNQRPDGIWVMYFAALGASHPRKHCLGAATSPNVTGPYTPLESTLVCDLPAGGNIDPNLFQDPVNGQNYLVYKTDGNTIGHGGACGNTNMPVAPTPLHLQLMDSNDLVTPVGEPVYLFSNIGAFEEDGPNVERPCMIFQDSTYYLLYNAQCYAELTYRIDFVSCTVGVDTQTGVLGCDWRALKQEQQTWQNRTLLHTGSSVSGFTLYAPGSMDVGPDQHKVVFHGDINLEWFKKDRSPNVHRVRALYAAEIDFAQATLHVTKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKR3</accession>
    <name>A0A0D2BKR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239724.1">
        <property type="nucleotide sequence ID" value="XM_016374448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKR3"/>
    <dbReference type="STRING" id="91928.A0A0D2BKR3"/>
    <dbReference type="GeneID" id="27327163"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00080"/>
    <dbReference type="HOGENOM" id="CLU_009665_18_0_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="470"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="615" mass="67638" checksum="BD5C0301EC228365" modified="2015-04-29" version="1">MTKIIIIGGGISGLSVYLFLHKHLLSSPTSARCDVRIYDPHSITASNFPGLRKHASDPADVETGDTEQSDSSTSPTTIGGAVGISRNGLDVISRLDTDPLRNTTIKQTVIRGHPIQYWDINTARGFKLASIRTSSTKKRADPPGDRVSVRDGDRDTASEVPDMVMIARQVFVEILYDRFKQIAPTPKDTLQHKKVVDVVVGDEQTPNIVKFADGTQEEADLVIGADGLRSVLRRAMFASSQGNRTDVEGHEDRRWYHSWLERASFGLMKVQDNSPKCDYITPHYEGLVGLGGFVPSSILRSTGHRPGSMSIVFGPNGFFGYGYLTSHVDRSREEDSSSASDSEEAVREGPLAGWWSTFSSKDPYPFHTTADDAQNRRDDDSTNNRSFDPFRAVTSLVSRHSTWKNCSVSAIVRYIRQSHAQGYGNPRKSEATSGSVRDGAGIETDSRFGLLQTSYPTYTTPELPHWHVGGRAILIGDAAHALQPSSGQGASQALEDSEALALVLAHHFNLSSSSSSSSSASLSSPAASTGGGIRNTEQRRHSYPYKAVEKALVTFETIRKPRVHTIYDYSQRMSRMKSDMGFVMEWIMSSFNRSYNDVLIEYDLPSVVRETIDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKR6</accession>
    <name>A0A0D2BKR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232065.1">
        <property type="nucleotide sequence ID" value="XM_016383442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKR6"/>
    <dbReference type="GeneID" id="27336205"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09122"/>
    <dbReference type="HOGENOM" id="CLU_1348935_0_0_1"/>
    <dbReference type="OrthoDB" id="4159681at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="203" mass="22027" checksum="DEB8F2052F258CCB" modified="2015-04-29" version="1">MFFSSPTSTITPAMTSVAMSRSDSRDSTTSNSCYNYTSYAPTSAYSALLSASPTSSWPSSQGLVRSDSNASSTVTSHPSSVAMRRDSSNSSWLPSPYRSCMSSFGAEPSSYLSDDDLLCTPESLPIETIPAVTPPKKELTTEEQIAFLRDLQEKEAASQQQAGSRRKTVRFAGPSEEKSRRPSTLKRRQTNVRRGLSSLNGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKY3</accession>
    <name>A0A0D2BKY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239824.1">
        <property type="nucleotide sequence ID" value="XM_016374548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKY3"/>
    <dbReference type="GeneID" id="27327264"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00181"/>
    <dbReference type="HOGENOM" id="CLU_074608_0_0_1"/>
    <dbReference type="OrthoDB" id="4121009at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34794" checksum="5B649D3182068132" modified="2015-04-29" version="1">MPKKKKGTKSARAEPYKATVPARRRSERIAQAVPEDTQTATEGLASPGLLLTGLPLEIRLEIFGYFTGAPTEYDEQERQKIELTRRSLLLVSRQVNTEWTPLFFNTTTIMFKAGRTDRAGFPTPSKATRQEENELHAMRIAVNVSDELLKSISLPKLEFVKKLHWEHTIAQARLGWHGGGVGQIADDRGLVRLSHALKHMKASLPNLTEVIYSNSTGYHTESFSATNDPSGKEHDHEHEFRRIDAGGRHQELANRLVGERRSSVLRGFVVDKKVIFEPGRYLGTQHLLYAQGFQIIFKKARGANSNSNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLK4</accession>
    <name>A0A0D2BLK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_00403</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240044.1">
        <property type="nucleotide sequence ID" value="XM_016374768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLK4"/>
    <dbReference type="STRING" id="91928.A0A0D2BLK4"/>
    <dbReference type="GeneID" id="27327486"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00403"/>
    <dbReference type="HOGENOM" id="CLU_048602_0_0_1"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW19828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="353" mass="39293" checksum="1F34A06B9FA00A55" modified="2015-04-29" version="1">MGWFWADTPKSSPAVVAPSSASPPPSCPMHKPSESNAAPFPPRQDAPQSIPSSCPVSRDPKHHPLLKSQSQSSPSVTETQHTSSSTSSTLSKLNPLNFMPSLSNARPTDSPQSISLPLDRETSTIPRADNDENWEYPSPQQMYNAMLRKGYTDTPAEHVESMVAVHNFLNEGAWREIEDWERIFAPGLSHAWEICSRGEKGIAFERAKQEFLAARREALGLPPSQEEEQFKPKLVRFQGRPKEPSPKARMLGLMGMIMPEKFGGEPPFDRHDWYVARRNPDGTVTEVRYVIDYYSGGVQATGEPVFYLDIRPALDTPTAAVERAMRWGGDVWHRATGASVREAAKRDAENNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM80</accession>
    <name>A0A0D2BM80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239931.1">
        <property type="nucleotide sequence ID" value="XM_016374655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM80"/>
    <dbReference type="STRING" id="91928.A0A0D2BM80"/>
    <dbReference type="GeneID" id="27327372"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00289"/>
    <dbReference type="HOGENOM" id="CLU_131037_1_0_1"/>
    <dbReference type="OrthoDB" id="4136894at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042776">
        <property type="entry name" value="Ribosomal_mL53_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L44, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="111" mass="12316" checksum="35BEF35DCB19623C" modified="2015-04-29" version="1">MITTYITSLKTAFNPFQANSKVPRLFLNLLPAEAHKSIKISAKQFPRTSTAPATLELGLKDGKTLNYSWGTDAIKSTATTEQKVKRTSLQDIVEEVNRHARVLDRKAELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMH1</accession>
    <name>A0A0D2BMH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexaprenyl pyrophosphate synthase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240001.1">
        <property type="nucleotide sequence ID" value="XM_016374725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMH1"/>
    <dbReference type="STRING" id="91928.A0A0D2BMH1"/>
    <dbReference type="GeneID" id="27327443"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00360"/>
    <dbReference type="HOGENOM" id="CLU_014015_1_0_1"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="50808" checksum="9D8B1A8D04C3DED0" modified="2015-04-29" version="1">MRVRISPSSSALLQPSVPVRASTASLPAVCPWCSTRSHSSRARESRRHFSSSQQSPSAWAAAVSKIQSTVADVLPSSGSSNATSNVTIDPLKLVAKELKFLNKNIRQLLGSGHPVLATVAKYYTQSEGKHVRPLLVLLMARATAFAAKQPRYESQNLSRSTIDTPISSPSVLYDNNPDQAAASEPPSPLTSTSNETYAFPDDASILPSQRRLAEITELIHTASLLHDDVIDHSTTRRSAPSANTTFGNKMAVLAGDFMLGRASVALARLRDPEVVELLATVIANLVEGEFMQLKNTASDESNPRWNEQAITYYLQKTYLKSASLISKSCRAAALLGQCAPSVVEAAYQYGKNLGLAFQLVDDMLDYTISAGELGKPAGADLELGLATAPLLFAWKDRPELGQLVGRKFSKEGDVQRAREIVLQSDGLKQTRALAQEYADKAISSISFFPPGEAKDGLEEMCVKVMKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMK9</accession>
    <name>A0A0D2BMK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240036.1">
        <property type="nucleotide sequence ID" value="XM_016374760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMK9"/>
    <dbReference type="GeneID" id="27327478"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00395"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="510" mass="56727" checksum="9108D5EC3EC9DB26" modified="2015-04-29" version="1">MDDSQKAQLPDPVLIEDVQDPPSGKLTVVQAYDSYTPEFAAQTERKLIRKVDLRLLPLVIVMYVSNYLDRNSITQARLYGLQQDLNVKGATYNTAISIFSAGYIVMQLPSTLMMTKVRPSIFLPTCIIAWAILSGLTSATQNASGLLALRFCLGLVEAPFFPCAIYLLSCWYTKRELGFRMSLLVSGLLLSNSFAGLISAGILSGMDGVGHIATWRWLFILEGSATVILGLIGYLVLPDYPATTKWLSEEEKIVAQARLTKSIGSDDFLTEETASVRRGVVWAAKDYRVWLFSCLQMATTADISYSHFFPTLIKDLGFKSNTETLLLTSPPYLFAFFFVVAICYFADRKQRRSVFAIVSICIAICSCIVLIATNEQNQWIRYAISFPLTAGTFSVYATTYTWLSSTIPQPAIKRAAAIGIANSWANLASLYANYFWLDGFAPTYRISWVIVLAFQVLGLASMVALRLSLKRSNRKFEKLSQEVSPSDTSALARLDIDERRAVVGNFRYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP04</accession>
    <name>A0A0D2BP04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240476.1">
        <property type="nucleotide sequence ID" value="XM_016375200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP04"/>
    <dbReference type="STRING" id="91928.A0A0D2BP04"/>
    <dbReference type="GeneID" id="27327918"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00835"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF242">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="453" mass="50392" checksum="A3CC9B193135CAE6" modified="2015-04-29" version="1">MSGLDILVVGAGLGGLGAAIALRLAGHNVIVLESAAEIGEVGAGIQVLPNSSKVLRSWGVFDKIEPSRICTTDACNILDWKGNLISSMDFGPAEKDYGSPFYDLHRADLHKALFDRAIELGAEIHISSLVTDVRFDETNVAVVTTKAGKVWHADLVVGADGLHSRCRSFILGKQDRPRHTGDMAYRLLLDGDELRSDPDFKPFLEDRAVTYWYGPGAHIVTYALRQRKLLNMVLLVPDDMPEDGPSTLAGQVNEMQDLFKDWDPRVSKLLAKCKSVLRWRLSIWDPIDTWVHPSGCMVLLGDSVHATLPYLASGAGMSFEDGAVLGHCLKGITKSAVTERRKALSLYESCRIKRTNRIVEKGSIQQDINHYNDGPEQIDRDQKMKAFEKLEEQYRQGKPVEWGNLVRGEDPLVWRKFGAGEWLLSYLPEEDVEKRRQELDADSAKSTIEAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPB1</accession>
    <name>A0A0D2BPB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRL1 family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233140.1">
        <property type="nucleotide sequence ID" value="XM_016382437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPB1"/>
    <dbReference type="STRING" id="91928.A0A0D2BPB1"/>
    <dbReference type="GeneID" id="27335194"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08111"/>
    <dbReference type="HOGENOM" id="CLU_010316_1_0_1"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051730">
        <property type="term" value="F:GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001690">
        <property type="entry name" value="tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012387">
        <property type="entry name" value="Trl1_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019634">
        <property type="entry name" value="tRNA_lig_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="6">
        <location>
            <begin position="63"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="5">
        <location>
            <begin position="389"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="4">
        <location>
            <begin position="554"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR019634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019634-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW12924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="820" mass="92509" checksum="9297C337AF9B9283" modified="2015-04-29" version="1">MSQDPHEVAELVKTLEANKGKGRGGHKGFSCKKTTFSVDGSQYTVDSWRFNDWDYKRNDLPTYARGLFTTRRSDGTPEIAIRGYDKFFNVDEVPNTQWVNIENDTTGPYELSVKENGCIIFMSGLEDGTLLVCSKHSTGSRSDAALSHAKVGEKWVHRHLESVGKSPRDLALALRKMNVTAVAELCDDEFEEHVLEYPPEAAGLYLHGLNLNLPEFATLSGPEVHEFADAWGFKKAEYIILQSLDKVKEFLAKCAETGSWEGRDTEGFVVRCKLKSKGATYAPAWFFKYKFEEPYLMYRQWRECTKSVIAGKPPKIRKHKKITEEYLTYARRRLALDPSIGKLYNQNHGIIKMREGFLAEIGQKGSDIIAHEREQGADGGGDGQISPVVLVPIATIGCGKTTVATALVHLFGFGHVQNDNIEGKRDRSQRFAYAVTDSIARHHRVVIADRNNHQKREREQIINDISKVLPETRFVALHYVHEPKNQMLDKIRRVTRERVLERGDNHQTIRAGSKGPDEIISIMEGFLHRFQGCNPDSPPDNDFDEIINLDVTASSLENLETVITHLYNAFPGLLPDAMPGDKEMREAIEFAMQQQVEKKHDLDFNKSGPSSRGQKNTPPPQQPKMFTADQLVAKLEYFSVPVSVTQINSVLSKLFDSGDAEEARMYRMLKQSRRIQGEFHVTLIHRASASQHADMWQMYTETYRNAIANVDLREKERLAPNLGKARVRLERLVWDDRIMTFVVRIFPADEGKMWPSANAIAHITVGTSGAEVKPVESNQLLSRWEAGDSAAGVIHDREVPGAIVLEGAVKPVFQRNTFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPG0</accession>
    <name>A0A0D2BPG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241044.1">
        <property type="nucleotide sequence ID" value="XM_016375768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPG0"/>
    <dbReference type="GeneID" id="27328489"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01406"/>
    <dbReference type="HOGENOM" id="CLU_580017_0_0_1"/>
    <dbReference type="OrthoDB" id="4154938at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="559" mass="62874" checksum="88CFEF65E94AC4FF" modified="2015-04-29" version="1">MATLINYDLTTFKQAKPNKRRLQDLQHSEARSHAARVSYWRKRNLPLTKTPQQGFSDLDKGVSPGTSSTSDQDVQSLPGSTGDIFLENRHSASSGELTFVHEHGSASESPSCAVGRRKHTSSVSHRGELSVSSHHRTRSDGNTKANGRRIAKKVEESRVEHLAFTRNPDYLFFEPIDSLRDHQRGDVITALDQYLNKWAPGQKPGLRHQTKDNPLIREVFYSALQNIELFESIIALMTSFQAAGQNFENRLCNVSLYHKGRALAGIRSKLGSGLVDEAVMLSTVFLMIIDNVFAEYESYRAHLDGLRRMAMAMPRIDETRYAGVLWTFLSWAESNALLLFGDSIGSGASVDIMTATNGQPQRMPKMTPKTIAALTPGFRDIAARKQISAQLTSTLESTIRWTKCIDDQSACRTKNDEDFLARFDPRMNNARAMRLSSCHEILERAICKALYLYHANVLGWSCRCAVYQSTVLDLAAILQTNTLEDAGHQELWMWLALLTANAARRGKLEQVQNEILAKLATGAERYWSIGTVIEKFLVHSMLEREWKQCWELAMMVQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQP3</accession>
    <name>A0A0D2BQP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_01373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241011.1">
        <property type="nucleotide sequence ID" value="XM_016375735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQP3"/>
    <dbReference type="STRING" id="91928.A0A0D2BQP3"/>
    <dbReference type="GeneID" id="27328456"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01373"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="49"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW20795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="561" mass="61197" checksum="EBF91E7318F5B41A" modified="2015-04-29" version="1">MSSIDIEEQKGHPSKAGLDGFPGPGSDHGDETAHIRADKLARKLSARQVQMIAIGGTIGTGLFLGTGKSLATGGPASTLIAYAIVGAIVFVTMLSLGEMAAFVPVAGSFCTYAGRFVDDSLGFALTWNYWFNDAVSTAADIIALQLLLKFWTDNFPGWAISLIFLIVVIFLNLMSVRVYGEVEYWLSLLKVVTIIIFIIIGIVVNCGGNREHKYIGGKYWYIGDAPFVDGIGGFASVFVTASFAYGGTESIAVTAGETKNPAKNLPKVVRNVFWRILLFYILSILLIGLNVPYNYPNLSEKSTATSPFTIVFTEVGSHVAGSFINAVILTSVISAANHALFAGSRLMYTLAVDGYAPKFLGGLNRFQVPSIAVLSTSTISGLCFGASYIGAGQLWTWLQNIVGVSNQLSWICIGLASLRFRAGIKAQGLEHLLPFKNWTYPVGPILAVGLNTVLVLVQGWSCFSPSFSGVDFVSFYIEIPIMLVMIVFWKLVKRTRFVRLHEMDLVTDRYDLHPEYQAEHEALSETDQTASAKKRWVHALKEGEEGTWLGRLKTVGMWLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRY0</accession>
    <name>A0A0D2BRY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1680-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241391.1">
        <property type="nucleotide sequence ID" value="XM_016376115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRY0"/>
    <dbReference type="STRING" id="91928.A0A0D2BRY0"/>
    <dbReference type="GeneID" id="27328838"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01755"/>
    <dbReference type="HOGENOM" id="CLU_016354_1_0_1"/>
    <dbReference type="OrthoDB" id="5358475at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151:SF0">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="83516" checksum="6A8A4715D4B7907E" modified="2015-04-29" version="1">MTDPELSWKKWNVRSPKDDPQQPIREPGSYNTTLLPLKFEPLPLGQVKPLGWLKQQLDLMADGLPGHLHEFYRLVKDAPWLGGDQEYSWLNEAWPYSYNALVPLAWLTDDARLKHHILRVTDWVISHQHADGWLGPETELSRRNFWGRYPLFLGFMQLVEAEPELGETMILPAMHRFVRLMDRMLSDNHQGYVWKPGDQFDEQWGRSRAADMVMALQWLYERYPMDNEKEIHRCIVHMYEMAYDWAYWFNEDNYLKNDLDTYPVALTDSLFPYVHGVNAGQGLKWAAVMRRLVQDDALLNTTRNGVNWTFQYHGTPSGAVIGDEREAGLSPVRGTELCSVVETMFSLNYLYQAVGDRDFADKSELAAYNALPVMFMLHWWAHQYIAQTNQPISHRLDASPFWNVGPWGQTFGTEPNFPCCTVNMQGYSKWVPASFVKVGDDGLAHALLGPAHVSTTLNNRNKIRIKCDTNYPFANYLNYEIKARSAFKFSFRVPGWAVLNESNLWVDSGKAHRLDPDSATGLHTMVIPAGRTRIEVMFGAHLRVEQRANDTVSIYHGALLYALPIAGDYSYTRPSRYPGDSAPPRARDWTILPRDPWNLAIDISTLKFYEYPNRYAESLPHPIWHEERPPVSVSALACEIDWELKDGYAPNPPPRGQRNCTGRAFPVELRPYGSAKLHMAELPTVDLRPGSHDLWRPEREREEEEEEQQQQQQTLGREGYKMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BV93</accession>
    <name>A0A0D2BV93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leo1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016379568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BV93"/>
    <dbReference type="STRING" id="91928.A0A0D2BV93"/>
    <dbReference type="GeneID" id="27332307"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05224"/>
    <dbReference type="HOGENOM" id="CLU_030892_0_0_1"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54960" checksum="19433127672AF239" modified="2015-04-29" version="1">MSSDLESAHSNSQHDTLDHQDVFNGADASDDGDLFGDDDDEPETANEVNRKLDDSELDSGDDEGRNDRIAETVEGGEDSPREEKSLKLMNIDMSRVKPPQGEELYLLNVPEFLGVKHKNFNPATYDPPERPHDGRDPGADSTTKFSPFSTAASTVFWRRDPKNPNLLQSNSRLVRWSDGSMTLQIASSPKDHYRISTTALRQGWPKKPGSSQADYDPNKDTHNYLAAPQAAVGVDIQIIAPFDASMKVQPTGDIADESVLKLQQSLAAATQMHDPLSSFKIINKDPEKRKKEAEEFEKQKARNARKVENAQDRLLLRKDRVLHRSGLGRSGGLSIQGLEDDEGMPMARGTKSQARRRKTNRRGEIYSDDEDEDYPRGRGRQDEYDREDDFLAASDEEPEVYDDEGGGEEVDAEDEDDPDVDDLEIEGRETLMEGRTRGGNRDRDRHRSSTPKRVAQDDDHDDGDAPADEPRGSPQARKKRRVIDDDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BY71</accession>
    <name>A0A0D2BY71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236480.1">
        <property type="nucleotide sequence ID" value="XM_016380653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BY71"/>
    <dbReference type="STRING" id="91928.A0A0D2BY71"/>
    <dbReference type="GeneID" id="27333398"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06315"/>
    <dbReference type="HOGENOM" id="CLU_120557_0_0_1"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="206" mass="22319" checksum="59B2C84E8DFFFBF9" modified="2015-04-29" version="1">MSQPLAPRPSQGLDGSINPPNSLKPRKISTACGACKQRKTRCTGGNPCEACASRKSPCVYDATSDQRRKIANQRNVQELADTQVQLERHRQLLGGILAIVKAGDANANEDLARVIRSGVDLSQLAAHVRNECRANTSIQVAFDKIDFTIDGPMELPSPSQILGREISRGDSGTAFMSPIEKSESNSDVTMHSVDQHPDRSTEGREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C1M1</accession>
    <name>A0A0D2C1M1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_04743</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237765.1">
        <property type="nucleotide sequence ID" value="XM_016379088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C1M1"/>
    <dbReference type="GeneID" id="27331826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04743"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="64"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="509" mass="57215" checksum="4594A3A08DCCB25D" modified="2015-04-29" version="1">MAEKSGNTEFQIEDTGAGPDSNRMTKVDTLHGDEAVIVLEAYDGESTWTKEEERRLVRKIDLRLLPILIMTFGLTFYDKVQLAHAAIFGLTKDLDLLVGNRYSMSSSIFYLGYISGSYPAVLLAQRYPIQRVIFGITFVWGLCVISCAGAFNYQGLFAQRFFLGVLESGISPVWMMVVGGWYRKEEQTFRMGVWYSAASIMSLLAPIVNYGLGHINGSLAPWRYMFIVAGVITTLWAFVILFVLESDPIHAKSLNEREKFIAISRLRENNSGIRNRHFKAPQLWELLTSAHFWLVFFMAVTINVSNAVPTTFNPIIIKAMGFSGLNALLLTMPTGGVGLVTTLGTAFLMAKYSKHNLRTLVIAGEVSLMLLSCCLMWQLPHAAVGARLFFLYLLSFYPAAYSLIMNLSIANAAGYTKRALTSSGLFVGYCCGNLIGPFLFLEHERPLYHTAWTSITVLTAICVLLALTYRLLCLWENKKREDAGFTESFEHAYEDDVTDRKNPHFRYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C4M5</accession>
    <name>A0A0D2C4M5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238730.1">
        <property type="nucleotide sequence ID" value="XM_016377160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C4M5"/>
    <dbReference type="GeneID" id="27329885"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02802"/>
    <dbReference type="HOGENOM" id="CLU_033924_3_1_1"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF20">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="396" mass="42750" checksum="4D6F847A25C7B680" modified="2015-04-29" version="1">MPTKVQGFSIVLALGAVLYQFFVKDVLFRTIGLGRTVLPVSSFPYQCRRILGDPNIQACEDMWLDENSRTLYLACSDPAARREWMPNVHRLNVSGRALNDHVVAMDIDSPSTSGGYTYRVLHTPGFPGVNGDGRIHVVGITGVASSAESDAQLWLVNDRPSVDATTGDFLDQEVVGANATIDVFATKPGADSMEHIKTYADPQIATPNNIAVTKDGGFFFTNDHGPHKVGWGHRLSSILGTGDVSYCSGTGDCRQVASGFKFPNGLHLGRDGLLYVPSAVKGDVTVFKPGADGSVTKVHYVQLDYPIDNLSEDANGDIFAATMPKCLATLAAFNDPLNAPTAPATVWRIRRLNRDVPGTYEYQLDKIIEDAAGEKLPVMTTVIHDAKTGTLFMSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C5C1</accession>
    <name>A0A0D2C5C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239010.1">
        <property type="nucleotide sequence ID" value="XM_016377440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C5C1"/>
    <dbReference type="STRING" id="91928.A0A0D2C5C1"/>
    <dbReference type="GeneID" id="27330166"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03083"/>
    <dbReference type="HOGENOM" id="CLU_076417_0_1_1"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000003">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="242" mass="27295" checksum="0E5B3A63323F67C1" modified="2015-04-29" version="1">MYTAPSSRPLPYAPTPYSYTPTNTLSARINLDEEVKLADSAAERDLVDSLAEIYSIIRTIDGLEKAYIKDALPENEYSDMCSKLLKQYRSILNDESVSREFVDLDTFTRKWDIECPRAKERLRVGLTADEVLTVQKATPYVAAPTTTASGSLILAATENFITFLDALRLSMVSKSALHPLLSDVIQSVNKVTDQDFEHRGKIIQWLITLNQMKTSEELSEEQARDLAFDMEQAYNGFKSIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6A2</accession>
    <name>A0A0D2C6A2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-processing-splicing factor 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239285.1">
        <property type="nucleotide sequence ID" value="XM_016377715.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2C6A2"/>
    <dbReference type="GeneID" id="27330442"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03359"/>
    <dbReference type="HOGENOM" id="CLU_000380_3_0_1"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="2126"/>
            <end position="2257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="2358" mass="273815" checksum="D03CA9F764738033" modified="2015-04-29" version="1">MASIPPPPPPGWNAGAPPPPPPGMAPPPPGYRPPVDPRVAKFAQKKKEWLRSQRNRFSEKRKGGFVETQKADMPPEHLRKIVKDIGDVSQKKFSSDKRSYLGALKYMPHAVFKLLENMPMPWESAREVKVLYHVNGCLTLVNEIPRVIEPVFHAQWATMWVCMRREKSDRRHFKRMRFPPFDDEEPPLSWSENIEDVEPLEPIQMELDENEDGPVYEWFYDHRPLLDTPHVNGPSYKKWNLSLPQMATLYRLSHQLLSDVVDKNYFHMFDRESFFTAKALNVAIPGGPRFEPLYKDIDPNDEDFGEFNAIDRIIFRAPIRTEYRVAFPYLYNSLPRSVKLSWYSHPQVVYVRSEDPNLPAFYFDPVINPISSRSVAPKNITVSHEDEIFGPGNNEDDEFELPGNVEPFLADEELYNNETSSAIALWWAPFPFDRRSGRMVRAQDVPLVKQWFLEHCPPGQPVKVRVSYQKLLKSYVLNELHKKKPKAQNKQDLLKTLKQTKFFQQTTIDWVEAGLQVCRQGFNMLNLLIHRKNLTYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLMREILRLTKLIVDAQVQYRLGNIDAFQLADGILYAFNHVGQLTGMYRYKYKLMHQIRSCKDLKHLIYYRFNSGPVGKGPGCGFWAPSWRVWLFFMRGIIPLLERWLGNLLSRQFEGRHSKGVAKTVTKQRVESHFDLELRASVMADLMDMMPEGIRQNKVNTVLQHLSEAWRCWKSNIPWKVPGLPAPIENIILRYVKSKADWWISVAHYNRERIRRGATVDKTVAKKNLGRLTRLWLKAEQERQHNYLKDGPYVSSEEAVAIYTTTVHWLESRKFMPIPFPSVSYKHDTKILILALERLREAYSVKGRLNQSQREELALIEQAYDSPGTTLARIKRFLLTQRAFKEVGIDMNDNYSSINPVYDVEPIEKITDAYLDQYLWYQASERKLFPSWVKPSDSEVPPLLVYKWAQGINNLTNVWETADGECNVMIETQLSKVYEKIDLTLLNRLLRLIMDHNLADYITSKNNVQLNYKDMNHTNSYGLIRGLQFSGFVFQYYGLVIDLLLLGLQRASELAGPPNAPNDFLQFRDRETETRHPIRLYTRYIDKIWVFLRFSAEDSKDLIQRFLTEQPDPNFENVIGYKNKKCWPRDSRMRLMRHDVNLGRAVFWDLKNRLPRSITTIEWDDTFASVYSRDNPNLLFSMCGFEVRILPKIRNPNDEFPIKDSVWALSNNETKERTAYAFLQVTEEDIQKFNNRIRQILMSSGSTTFTKIANKWNTTLIALFTYYREAAVSTVNLLDTIVKCETKIQTRVKIGLNSKMPSRFPPAVFYTPKELGGLGMISGSHILIPTSDKRWFKQTDTGVTHYRAGMSHDEETLIPNIFRYVAPWQSEFIDSQRVWTEYSQKRLEAQQQNRRLTLEDLEDSFDRGLPRINTLFQKDRSTLSFDKGFRARTEFKQYQIMKSNPFWWTSQRHDGKLWNLNSYRTDVIQALGGVETILEHTLFKATAFPSWEGLFWERASGFEESMKYKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFLHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVFDQELEQLGIETVQKETIHPRKSYKMNSSCADILLFASHKWNVTRPSLLFDTKDQIEATTTNKMWIDVQLRYGDYDSHDIERYVRAKYLDYTTDSMSIYPSATGLMIGIDLAYNLYSAYGQYFPGLKALVQQAMAKIMKANPALYVLRERIRKGLQLYASESTQEFLNSQNYSELFSNQTQLFIDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQLIVTRKGLLDPLEVHLLDFPNISIRASELQLPFQAAMKVEKLADMILQAKEPQMVLFNLYDEWLKTISSYTAFSRLILLLRALHVNTDKTKLLLRPDKTVITQAHHIWPSLSDEDWVKVEVQLRDMILNDYGKKNNVNVQSLTNSEIRDIILGQEIAAPSMQRQQAAEIEKQQQDQQQLTAVTTKTQNVRGEEIIVTTTSQYEQQSFASKTEWRTRAIATTNLRNRSNNIYISSDDIHEAEDAYTYIMPKNTLKKFIAIADLRVQVAGYLYGSSPPDNDQVKEIRTIVMVPQVGSTREVQLPHQLPQHEYLKSMEPLGIIHTTSGNETSYMTPADVTQHARLMAQHPSWDKKTITLTVSFTPGSVSLSAWSLTPAGYTWGASNKDTQSDNPAGFSTSFGVKTQLLLSDKIRGYFLVPETEVWNYSFMGAGFSTVEKRPVYVKIDTPRRFYDDRHRPIHFSSFNELEDIWADREDVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8M8</accession>
    <name>A0A0D2C8M8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240115.1">
        <property type="nucleotide sequence ID" value="XM_016374839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C8M8"/>
    <dbReference type="GeneID" id="27327557"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00474"/>
    <dbReference type="HOGENOM" id="CLU_313529_0_0_1"/>
    <dbReference type="OrthoDB" id="4120501at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="934" mass="103705" checksum="C79A2D87A85F3F75" modified="2015-04-29" version="1">MPVPLHIPATASVWALSDTADKTVTMTRGLLEAMTSDDISPAALLTCGSFGSLLPVSPETRLKVEQLARRNHTCHALNFIKAQIGYKKDDSVEQLSRSDSGIRFLCLVATLCTLDHYDAADRLDSLLEATQRGFQIRPTIKQLQIMLNSMRTKMILSDFATSVAGFETMLRASLEGQGPLYYIGIAQIPTKESLQELVIAMNQLGRIADEDSIETIDVRLNSCYAPWTCAFIKWLLGAPPLVRTAQGRTLLRQEQASVTLTILSRLPGSNPHKSTGDGKSRIEVVPVQKLRCLRDIIFLEPTSEPRYAWQGLVSAQDWVDYQFSILYDKFPRLRKQGKLRKALGQALYFIVAKVPGRLVLCHDFDDFKHGISYYDGYVEDLFHPTAPKAFLNSEVRVRITNELVKGHITLVQDNNDESGALLPINLAQTLEAGCRKCQNPINGIIIQHPPCAVYDLLEWVGEVGSTLLTLTLFGPHREAFPMLKAGQMMNSASTTFHHRIFQPGRKQAIWSASFSELIMNGWQALMHGRCAYLSCPPMAIFQHAAKMMGHQNVSDSTVISSLWGQVLFPVFFEAPEFLSEGFLQMSAFPGKLRRGDMQFDFLLDSWSNRISTEGPSGAETMIVDFDLDLEGQSHEHVGRRRGCNRGGDDDDDDDDDEQMMDEAGLDPLEREEEVEDGDEISTEGPSDAETKVVDLDLDLDGQGHNHVNRSRGGSTGGDGADEQMVDEVGLDTPDDDDEFEDDDDDDDYDDKRDSADNGTENHRRDYAPPSTTDVNSGCTAGRPPVGMVPASFAGARRRRLVMSAEVMKWTISIRDAMLHGELRLQEDDDDGEMMIAWSLVGSLARARLSPICTHPYNNPAGPLAASFELVRDIDRLHGHGWRRRSLIVVGQSYAAQLKALQFQDIYRPVVVHVDGCIQCAMRLGLADRVGVVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C9U7</accession>
    <name>A0A0D2C9U7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240560.1">
        <property type="nucleotide sequence ID" value="XM_016375284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C9U7"/>
    <dbReference type="STRING" id="91928.A0A0D2C9U7"/>
    <dbReference type="GeneID" id="27328002"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00919"/>
    <dbReference type="HOGENOM" id="CLU_060775_0_0_1"/>
    <dbReference type="OrthoDB" id="5365739at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="394" mass="43284" checksum="DDFA3C7EFD3F892C" modified="2015-04-29" version="1">MDHLCTRCARLSLRVKPSSSAFLPPSALRRFSAGRSLLADDDSKTSNINASSSGPRILREKTGPKGTGSSQLVRGSGAPAQRGTLLRRTSPGSTTAARAGAASTPPGQRPSINRASTSGSRPSPPGPILRRTATPRDGTSTRPPFQRNGQRSSKPGNAPAGRGTGPRVDKRIQRRDQRKARKSAEDEDGDDDLAIEEKADHWVNTVIDPPPNPTEEITYTPGQNMAVKDLRADWPNTPLSGTGLTETVQQRIEWLAQRIPHGYQTPGQLAERYVKGYFTRFESEEEKAEVLKLAAEMAQKRADRVTERKNIEAKPHDMSFSDVVSRQAERQGLADTYVRGEYPTVQKQKMPFLDHVVENLNNNGTYQGTQTKQFMKTIRRLMVAGQPSQAPKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAJ8</accession>
    <name>A0A0D2CAJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240810.1">
        <property type="nucleotide sequence ID" value="XM_016375534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CAJ8"/>
    <dbReference type="STRING" id="91928.A0A0D2CAJ8"/>
    <dbReference type="GeneID" id="27328252"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01169"/>
    <dbReference type="HOGENOM" id="CLU_007263_2_0_1"/>
    <dbReference type="OrthoDB" id="5591786at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="842" mass="94025" checksum="A3C2A0565DA1A0AB" modified="2015-04-29" version="1">MEHDLRSFKSVNIGLTCLETGSSRFTRDGIYRPPPVAFWRNNLTALSQRYNLYFVALRDAFAVYRPEFPFQRLHWLPSLVIPPELANPSAQGYIDPHHPHNINHIMVDDLGSEEILLLSTDSGNLTAYFTKAIDEAIRKDPYRFSTNARSDCVGVRAFFTQWVYESAWGLSIHSKARMIAVSANTPNHVPSDDPCSKITVFAFALTEHGSGYPILQIDAHANSQLDVSDLGLQQDWEEWDCRRPDSGPPPRNRNYKITLGGLEGHNDNVPSISFVNTDDDPDGRWLLSTDIRGEMKMWQIWRGLCLRTWSFAEKRMRGGFQSRREGGWIVAALDSRAFRSAWTMEQFCGHTKAPQYYGHVGESYDLTNIVRLRTPGISLAHPHAQGFSPADAPVEEEEVQEQTYDGWSDLDDSGDEQANANSGPIAQDVLGAGHPMPPTVSISPLLPQESEATESGILNNLDIDVDVQASDADGSEELSEHDADSGMLLLFDHEQYDDDVEDDEMQYGSSSEDQEEQSYSSSRRSTPSLSSLAQRNSEALEQQPGDTDTDSSSFMEHHHLAATAIQGAKSTSRQTRGIATRKDILQIPTLHCTASHLRLLMAPQASSPHVFCANILKQALPEYIEMTNHVHLDRINMVQQIPELGIVIVATQIGRCAICTTTRNEKTGTLGLRVDWVLPTTKQEARHLRPAMPLLGIAASPIQGRFRGEEHKSRPAVEMSVEWGKDAVVDGVTTTFDPESAAVVEDGVEEVTCPISAREQGKHGKMPECPTRFDPSTSNHTPQHAAWTKPEAIEPWMSTESSRRYRLMLTYLDMSVLTYEISRGVEREDLLLRETSTLEDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAL4</accession>
    <name>A0A0D2CAL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240825.1">
        <property type="nucleotide sequence ID" value="XM_016375549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CAL4"/>
    <dbReference type="GeneID" id="27328267"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01184"/>
    <dbReference type="HOGENOM" id="CLU_839468_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="331" mass="36989" checksum="59A4BAE0AEC29587" modified="2015-04-29" version="1">MPILAEVDRAISAAIEAYQFIQRYRRADKEIQELGSDILALTAVLDSIATVCETTPDSKCLDALRLPLITCSLNIKTLKDRLPDSAKERNGELKSPLPFLSAKFAREGKTGLDSLRRSLLECKAILKLALSNTQLRFQNSLDLNSAEMRQAQDEVRPKLRGLEPRIAARDADSDAQIAGYDGRDEPRPNEDEEAGSGHALKKYRLQLRERPENLNSPGGPVNDQTSNTRQYSGNSQGMLARASTNPQRRQPVSRGYSDSSESVPRTPTRTQHQHSDAETYSGSSRGQPDSSQRGIIDGSSTHYRRLSTEESLANDLRDRRRERHPRYNGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CC66</accession>
    <name>A0A0D2CC66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241280.1">
        <property type="nucleotide sequence ID" value="XM_016376004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CC66"/>
    <dbReference type="STRING" id="91928.A0A0D2CC66"/>
    <dbReference type="GeneID" id="27328726"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01643"/>
    <dbReference type="HOGENOM" id="CLU_003254_0_0_1"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="3">
        <location>
            <begin position="356"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="299"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1146"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1185"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1208" mass="135170" checksum="55D3B6A547425B48" modified="2015-04-29" version="1">MEIDSSAPNGAEESRRKSGRVTRRPELFSQEHQQSNPVLNGSSKRKRPADNEGADLDEDDQEEDSEESDADESEDEPDEEELKERRRVQRSKVATKPAAKRAKRADSSGTTLAMRPAKGARAAGGKAAKAQTARSRPSQAHLQGLYAEVFGKGRSPEDAASSWFQSVQSDSVTGIRDLINFVLQCIGCDSRIESQDVEDLDSVPTKLGDVLQEYEAQKSPDYPLISKQKQYAGFQTVLEEFFKAIIKALHASSLFYEQPEVYDNIHVWIATMSGANYKSFRHTATIISLSMSTALCEVAKELQETMASLKTQMDAEKKKRSVNKARVQTIEASQKETEQKLEAIDAQLRDAFDTVYVHRYRDIEEKIRAPCVAALGNWIVLYRKMFLEGQFLRYLGWVLNDTSSPTRLEDVKQLKILFKNKKNIAALRAFTDRFRPRLVEMGARDADISVRVEAIELLDRLRDAELLEPDNIDTIGRLIFDSEPRIRRAVAKFFVSNIEDLYGLSTEEFDEAQYHAALPDDDDVEEYTVPTRSWIKFKCLGSILAGYDNDEESLDGKADRSLPLDLAVDSRYTLATQAIYPHMKELHHWESLAGYLLYDHSSISASDEGEDMNIQVQQAYQLSPGEDIILLDVLNASVKQYLSSILEPPTNRRANATKDQIREKQESAAQSLTQILPQLLSKFGATPQAASSILRIEQLLDIGLINDLQSGEATYSAILDDITKQFTSHSDKKVLAAASVALRNARSFEQSKEVVDSKVQEIWAESVTMITDLLRGKDVEKRGTLDKQSLAAMVNSMTRLTELAGVYDCSAPMETKLPVPGGRKQKGKSDQSMDSLLSLLLRLLRRGEPDEDTTWVFNELEDQLCTALVELFSRYFRWKMVALKNAIATNNTTLLSTSNLTGLAMTRTTFVDNLEAVISLRTPLDSVRCAAIVNILELFALFTTIRNMHPEKGELDETIARNLRSLVTVVPSEIVKEVMTTHERMERNFAKRTKRKIETGREKTNRAGARADEDDEDIEKPPEDSDEEEEPESDLDDEDEEDEAAAGRGGKRAKRQAALLAEQGLCELTSKIIFAIVGGAIKDDSVKRRVLLNRTKLGKNYAALVAYLDDKKQPRAKGKKVAVPAGPKTAQQQQNQKKAAVSAEMVLDDDDIEDSVMDEEEEQHRRDLAEDDLDGQDARDHGEAHDDDVDDDDGVPGGEVEEDDVMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y4T2</accession>
    <name>A0A0D1Y4T2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230152.1">
        <property type="nucleotide sequence ID" value="XM_016386020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y4T2"/>
    <dbReference type="STRING" id="91928.A0A0D1Y4T2"/>
    <dbReference type="GeneID" id="27338795"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11712"/>
    <dbReference type="HOGENOM" id="CLU_059575_0_0_1"/>
    <dbReference type="OrthoDB" id="4121018at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002246653" evidence="1">
        <location>
            <begin position="20"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="332" mass="36264" checksum="FA75EC70B8AF68C8" modified="2015-04-29" version="1">MVTLTRGLILVASFGAALADAWQQTTTTALTTVTPCPSPAQWKTPAPITVTAQYQPVSTCSALDEVCVKNKCFTKYSYSTWNYVSTTIPCPFAAPSSTISTITATDQSVLVSRTSTTITNTQITSTVTKKWKRPFTHIVTVSAYTTVVKEWSAPYNQLGSLAIPGYGGSGICTDCKGDNGQKRQSLDVIECFESRNKPTICREYKEVWIYNPRAIFSHTASAVCSSRTSVPSAGTYVFEFPQKAPPTTIEIPVQKVTHTWHGGVIVSTNAATTAVFPGRDWTATVTRHCARPTVIEFDIIITKVIVYVVPPFVFPDGPTKTDIYFGTMVYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8B8</accession>
    <name>A0A0D1Y8B8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231452.1">
        <property type="nucleotide sequence ID" value="XM_016384850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y8B8"/>
    <dbReference type="STRING" id="91928.A0A0D1Y8B8"/>
    <dbReference type="GeneID" id="27337619"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10536"/>
    <dbReference type="HOGENOM" id="CLU_024934_9_2_1"/>
    <dbReference type="OrthoDB" id="3031538at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF11">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="447" mass="50697" checksum="53BD4824B5481B6A" modified="2015-04-29" version="1">MNASTATGVQSHKGDAAISRKRKIHRKSRLGCRNCKLRRIKCDEQRPMCEKCVSFGVTCNYNALVPDLQPSANVTHTLANDQTSDERLVSTCFSANRHMLSMVNMYLNVDIESDAALQRDLTSSDMDRLNRFQSRTITTMGTKSTARHYRKEMIHLAFNNRYLMHLVQSMTALHDRFLAGKAIAKQTPDENYHMAQGLRGVQAKLSHPLKAEDRDALFVSASLIGVITFFYIEAESMGDVWPLADGDLSWVSLSDGKRAIWRATNPLRADSVWRPIAEFYERDFMSGQQVTPAQVLSPFDHLCSERDDSIDALTNPYHKTAKYLISLLGLEMNDATWIRFLAFICHVDPPFKQLLEAKDPWALLMLAYWFMKICRGAWWASTRAVVQGQAICLYLERHHADDQDLQKAIPLAKKELESAQKEGWAGLEDVLLFGPEYVQHVKPAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YA54</accession>
    <name>A0A0D1YA54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232047.1">
        <property type="nucleotide sequence ID" value="XM_016383424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YA54"/>
    <dbReference type="STRING" id="91928.A0A0D1YA54"/>
    <dbReference type="GeneID" id="27336187"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09104"/>
    <dbReference type="HOGENOM" id="CLU_010194_8_0_1"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="302" mass="32216" checksum="FCE95DC18CCB6FE5" modified="2015-04-29" version="1">MENLPPDFWATSGAYTPHIYRDQYPSIDPASSKLSQAGKTIIITGASAGIGRRGIVPAFAKAGPKALVLVARSLASLEATEAVVREINPSIKVLLVPTSISDEAAVTSLYETVRTTLGHADVLVNNAGSNTEVALIGDSTPAKWWADFETNVRGTYLMTRGFLQLLGPEQKGTVITLNTGLATAVVPSWSSYSISKIASLQLVDYLAAEYSNVSAVSIQPGVVDTDMVNESFKRFAQDTPELVGGTCVWLATDAARFLSGRFVSANWSVDDLQAQKDHIVSSSDLKVAYQGTFGLDKIRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YAY8</accession>
    <name>A0A0D1YAY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232287.1">
        <property type="nucleotide sequence ID" value="XM_016383664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YAY8"/>
    <dbReference type="STRING" id="91928.A0A0D1YAY8"/>
    <dbReference type="GeneID" id="27336428"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09345"/>
    <dbReference type="HOGENOM" id="CLU_018776_0_0_1"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="663"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="800" mass="88495" checksum="CE2F144229367EE7" modified="2015-04-29" version="1">MSARTRRSGRERKVNPRYANDGWDKDTLRILRASSESSGSSPDDDQGSENAEIVEQDDEGSFEEDEGASSASDVRSQFSDVQDPNEDEDNMSLASDDQTMETPRLQTNRGRSGTRDGRGGVGASTTTPTHSRGLARLEPKGAKGLVYRHIFGPELDDLEEVLAARDTWLLGRDVTLPSRKTLSVTFQRADQARRDKQSDPSKEPKQHLHPPRLPESVVDLILNQQLLKPIEPDELYERYLHRHKPSHSVVLGPFGRQQLYTLDYNLPMDFGWAWPKVSDAGRDQTSQTSQRYHEGWLVNAGEKINCLAWAPQQQDAQYLAVATRCTSHQRQLAGGNENMRPAFHPSPPYPSSIQIWAFPTKPTSAPGLRTIAMNLKPKLCTVIGTEYGNIRAMKWCPSTQNPPSTFSTGAAFIGILAILCTDGSVHVLAIPSQLPTPITLKAERSGLTFSPPGGTVFTTLTFATSTDLVIGAADGTVHLFDLSDPTGLDPPRSYTSPQIHSTYITSLSAASPVHLTPFIATASSAGDMALTDLRSPTQDKVTVTRACFPSRDIYFAPFTRSFITGLDRVGSTRMDTHSAAFLACHHVRQFHSSLRLAKLPDHSGTATALSGSPHHPCILVGNAKGQVHATNYLRKILPYRRTEPGKRVMAFLQKLCEYDWRPAETGRRDDDDDDDTDVETHHLHHRQRQSRTAAADADARQHATRDKPEQEIDLFHGHDVRPGVSRFHEGFKPERINLAYVPDTKKKGPSKDTWAAETIFEEEQAVTVLEWNPNESCAGMAAVGWASGMVRVQDLAHDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YBX4</accession>
    <name>A0A0D1YBX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232642.1">
        <property type="nucleotide sequence ID" value="XM_016384019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YBX4"/>
    <dbReference type="GeneID" id="27336786"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09703"/>
    <dbReference type="HOGENOM" id="CLU_527858_0_0_1"/>
    <dbReference type="OrthoDB" id="2247093at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="541" mass="57917" checksum="834A538DA05500B7" modified="2015-04-29" version="1">MSQTSPTDRASNTSFALPGTQTAASQAAGPNADSSRPSTASFARTEAYSNLDGPVHGRQGADINSGFESRRPSADSSVQTPSRAFGVHSILNPQTEPEGQPLAAATSSQSHAGFPQGPPEESPRVRKRTDLRSSAQEHSQSGSARVGRRVLTPKSPAVRAASLGARRNPTFHSTIQPLQPFSGSTGRNYTAESGPYRTSEIPPLPSLAIATGPNLPSIAPLEPGTQTRSAPAPGNSPRGLESVVTHTADRALPGQPTYSRIEQPSPLFRYGPGQPLSQPSPAHRGFPPSGPGGYGHETHLHGPHEGYQAGQTSMNLTLDTDQGPLVLPVELDLQQASRVADEKRKRNAGASARFRARRKEKEKEASQTISGLQQEMRDLIEERDFYLSERDHFRELAARHGANPQLLQRPPSPRQRRLAATAAAASAGPAPTSGASSEPQFGSEDSYREYHDRESSSQRRRTGDYQPIFVAASTQSPSQPGYSGFPPQPPMPLPPPPTTTSSSYAASRSLPPGPAAPSITRSRSYDPFHRDPYDRTWPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YC62</accession>
    <name>A0A0D1YC62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232707.1">
        <property type="nucleotide sequence ID" value="XM_016384084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YC62"/>
    <dbReference type="STRING" id="91928.A0A0D1YC62"/>
    <dbReference type="GeneID" id="27336851"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09768"/>
    <dbReference type="HOGENOM" id="CLU_008964_7_3_1"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF149">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="36"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="610"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="79966" checksum="F31D7BD947296F1E" modified="2015-04-29" version="1">MADTDLRMPDVQLQTPQHEELLNIIDTLRSLGIGRYVDLPQIIVCGDQSSGKSSALEAISGLRFPTKDNLCTRFATELILRRAPVASVTVTIIPAPDCPEEIAKVLSFFKPPSNSIDEFAKIVLAAEEAMGLNGSNKVFSKDVLRVELCGPTQPHLTLVDLPGIFWAGDKSQSDDDATLVRSLVESYMKKTRSIVLAVISAKSDLAMQVITKLAREIDPQGLRTMGIITKPDLLHADSDSETAFVKLAKNENIQFKLGWHVLKNRDYDTRHTTRAERDAAEEEFFDKRVWSSALMKSQLGVATLRPRLSRVLLAQILTELPGLVQDVGSELQNCKDRLAQLGEPRGTLGEQRLYLLKASHTFVDLMRSAVGGSYFDAFFGSSETSEGYNKRLRAVIQYKMAAFAEKMTKEGQDVQIVDEKIAAQFRGSSFKVISRDKYLEQVTERMRRNRGLELPGLFNPSIVGDLFYEQAKPWSSIVGDTAEELVNSVRTTVDLVLDRSADSVTKEGILRHIILPNMDPICDKLYSKVEEVLRPHVRGHPLTFNHYFTENLQKKRQKQTSASVMAKLRSFFGLRASVTDEQIIQPSFSLKNLVKTLVVESELDMEKFASIEALNAMQAYYKVALKSIVDSFGMYAVEDCLLQPLPEIFSPEIVFGLKDEVVTAIAGESQEIAAEREDLEKKLESLQRTMHTLARLKTLKSPGKDYSVPRKINRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YFC9</accession>
    <name>A0A0D1YFC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234012.1">
        <property type="nucleotide sequence ID" value="XM_016383309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YFC9"/>
    <dbReference type="GeneID" id="27336071"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08988"/>
    <dbReference type="HOGENOM" id="CLU_877268_0_0_1"/>
    <dbReference type="OrthoDB" id="4120620at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35512" checksum="485BC04783CEEE6E" modified="2015-04-29" version="1">MTSADLDAVTTTLDDAFAPGAIATYVYQFRDNYPSYHWRCYREGLAMEYDLPTKRQRCFNVIIPPDGNENEARSAAGWKVMERGEMGGLGMFGALLGLDKRVFSAMSTRDLRERRKQVRLSPHIHGHESDPAGLFGISEVELDCSLQLDMNITRTAHLLPQMHAAVQTYIENAYDRQLYLGILATHPDWDGHGFGAAQVQWGLKFAQAEERRLTLLQKKQVKMPVTLLATPAGYPLYKSLGFENVANVTFELLAPFPQSTTCGLGVTFEPLENRRKTYQEGMSHSCIDPAGSWTSLSCGNDTTDIGAENEYEFKRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YGM0</accession>
    <name>A0A0D1YGM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234357.1">
        <property type="nucleotide sequence ID" value="XM_016381255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YGM0"/>
    <dbReference type="STRING" id="91928.A0A0D1YGM0"/>
    <dbReference type="GeneID" id="27334005"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06922"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="467" mass="51235" checksum="F23E65D56383504E" modified="2015-04-29" version="1">MPSIKLHVGVCGGGMGGLAAAIAIARTGAQVTLLEAARELGEIGAGIQVFPNVSRLLIRWGVDELIGDNLITVDEANTWAADGTLLAHFDPKQGAKQSGFPHWLLVRRDHLHAGLTESARRHGVNLVVDSRVNKLEYTKESVKVTTTQGVHHEFNLLIGSDGIKSFIRQTLFPDVVPKAASTVAAFRGILSYGEVFAKVPDARQFLRNTMDGLIGPNGYILLYPLSAGRELNVVTLFQMDRVVRTPEDVDINEFRNLYKDWNPTARKILELVNYTQKWPLLVLPPMKTWSNDHKNIVLLGDAAHAMQNHMAQGAATAMEDGAFLGTVIGDVVRGNISLTEAIELYEKQRIPRVWVKQQASFVSGAINMAVGEDAARRNRASAPEVKAWGCNVVQPSNELPPTYKSWQMYCTPASVPGILYYDAEGDADNAVCEYLQKKTAVDEVTLVSKGLWEKWWGVIDNNGLEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YH10</accession>
    <name>A0A0D1YH10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234477.1">
        <property type="nucleotide sequence ID" value="XM_016381375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YH10"/>
    <dbReference type="STRING" id="91928.A0A0D1YH10"/>
    <dbReference type="GeneID" id="27334126"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07043"/>
    <dbReference type="HOGENOM" id="CLU_655523_0_0_1"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="136"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="136"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="412" mass="45878" checksum="F6EDA0E068EA7FB6" modified="2015-04-29" version="1">MENSDPFTVDPSGQSKHDLDSIWLMAKATFASNNNQITIPTVVAEELSGKDLQELKKRFSAHFGNVDTIVFIDDTAKVFRICSVSDVAMSTPPAGAPASLESVSSSTRQPGSAQVDHTKTSAIAPKLRLPRRNARVPRPPNAFILYRKKHHALLKAVQPDLPNNDISIILGKQWKQESEGVKNYFKTMAEIIKVQHAKANPGYQYTPRKPSEKKRRMTARKRARLNAANTDSDSVSISDHEMTDVPDSPENGVSATEPTVVLNFLTDETDNLHAPVTHDQSAESSQYNSLGLVEHDEYSDDMTLKVPSGHKFAEMDYDSLIHSLYKSMKSMERGGLRHEITCSTPDEASYVIRDANTVVDWAGFEADRKLIEDTIAANADESAERLGTETFANAAEHEAFKEEFDQLLWMWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YHJ5</accession>
    <name>A0A0D1YHJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234612.1">
        <property type="nucleotide sequence ID" value="XM_016381510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YHJ5"/>
    <dbReference type="GeneID" id="27334261"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07178"/>
    <dbReference type="HOGENOM" id="CLU_393291_0_0_1"/>
    <dbReference type="OrthoDB" id="4161538at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="673" mass="77410" checksum="D0080EC28E773D35" modified="2015-04-29" version="1">MSVSDERSYFTRIEGAIMADAAAKVEAECARAVERSLPNFIMSMEKASVDCGLLVDGAISNSDLAERVIEANRVYGGTKKLIPLDIKHIRPTLSRSSTAGGYYNYRIHCMPMQKVVPAFIVQNPIAPEYVAVIPHWYLDRDWPPRSKPTKFHTYHSLDIALVGPYYTAFPPEWVPFVMPLDRLHDALQSLQNYATGVGGANWKNPYSGVEFDHCPRPRLEPVRLTLPQDGIASDHDDILAIHRALEKYSQSYQVRLPRTKPGAGDFYIERCDKRRLIVELKRDEVKHMDNGDIHIQYIKQRRVRKKSFLDPLSQWNLLFVLTKTPSRLFVFARDELPEDWFQLDPRQTAEAVLQHGYLNLTDHEVQWNRGTERAVQTLEKFLDRYICRADSTSTQPRSQGKVLTPELRRNLLGHLPEEEDHPPAGTLTGANKISQNPSRRWSRRLWEARQMRWLVGECEKRHFGLVYVLGHAHPSGTHLFVPIPLDTMSKRPDLHELSPDTPVLFLNFAPLDEMAWRVPTDHRRPNCYLKATHGSTPSMFVLCGVEEAVDTYQHGRYLVPSTTLASEQQIEHHENIILNGMSNMGKQTPVYLSHGEMIDTYRLSEDDVVPRLRRVSEEFQNERHLYMGRPLTAAGVTVDLEAFITNLRTVNQQWIRYLSRDIDERLIKLEAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YI19</accession>
    <name>A0A0D1YI19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234772.1">
        <property type="nucleotide sequence ID" value="XM_016381670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YI19"/>
    <dbReference type="STRING" id="91928.A0A0D1YI19"/>
    <dbReference type="GeneID" id="27334423"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07340"/>
    <dbReference type="HOGENOM" id="CLU_011409_12_1_1"/>
    <dbReference type="OrthoDB" id="3145928at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="555" mass="63275" checksum="C8DAD52EF58F1544" modified="2015-04-29" version="1">MPLETEHRRPRRRARHEKSNNGCSTCKIRRIKCDETTPQCRRCTASGRECSGPLTRQFRFVEDPVMDRTPSPVFQLEVSLLSPRRSEPERRAFQFFEQDTVLHMPGTIDENFVGSLLPCLAHTYDFIWDTIVSVSYLIKYVPYLALTTVDSAGLTKVINKEHRQALSYYHRAILSVRQMAEIGPIDECIVVLSYIQFAGVEFRQRNVKVGHYLFKKACSILSRSLASRTLRHDSPAHRAIHQVVTPFIFRKAVVIATLGDVPTPESAAEDEISRILLAKSPELQQARVELYSLVSDCYELVRIADFIPNIEDGNSDKAYYMSHWQSSLDGLRAWKAKMIASGSPKPCTDTECIYSYLMIYCNICYISVATCLSISQMIFDKYTDGFAEIIHHAKVFLGYCVESPNVQLLLQFDPGIVPLLYFCATKCRDPMLRREALCLMSQALRQERENHWALIEPERVVETLIAVEEDEKRPLDSVAPSSSSLQTFSSQTPLKRALPPDGRRYTHASAVLRQAPGGRLRLAVELVRFETGIRGQRKSITDYAWLDDPYDKIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIN3</accession>
    <name>A0A0D1YIN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235012.1">
        <property type="nucleotide sequence ID" value="XM_016381910.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1YIN3"/>
    <dbReference type="GeneID" id="27334664"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07581"/>
    <dbReference type="HOGENOM" id="CLU_000595_0_0_1"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="8">
        <location>
            <begin position="511"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1329"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1422"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1357"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1451" mass="162481" checksum="6CFEF6CD456A3450" modified="2015-04-29" version="1">MPWKPLPLAYAVARYPFQPSASPTELPLQIGDQLYVIEQGGKDGAWCRGYLVAPPTLLSALTPAGRTAADARVFSGIFPKCCIEIREQLGSGISAVAQPGEPKPQAPVPMLKIGDDSPTSSTEPLVDEISSCLREWYILHLPDLVLRREYRVLDQMSEITSRLDYARRELLNDVLTAQERLQVRSDAVWDLVRGNKMLSGEVIVRDATQHGRLLTSDDSAIEMTKLQAIMSVLESPPSEKSRATSLHHCLLDVISVVGSDLESASLNLALYRKDSDGNLESFSETYSSIASAKMKTLFSDLSKRDIGDGGEIFLTVKVTISEPPRKAKRRAPERPPSRNGTLLGQRQLSLNRRRSSMMFGKKKYAEKPQPGINGRATPQTNARAQTPSIAEEEDGSAPAQGPPVPRTVAVGVLDVSTLMREGKPHEETITMWSVSPRDDEKRREADPKIVQLLNSHGRSLVVSPYISSVALRLTPYTAPDADTMVRNNPTSMHLVTKTQKIGFSEAPSRPRSDIYLRLNKAIITQGAHLSHPELNVTPIKAHSMQNLQLTMEVRDSSGRRIEHCIYPSSNGAAVTALRTNAVELDSAWDQTLCLRIPTDKVPDSHLIISIADAPEFPFALAWMPLWDKHAFVSDGKHSLILHAYDKITSSVVQGRGAYLSLHWNHATYKTVHEGSYANIASLEVSTLLCSTEYSQDRTLVSLIKWKHQTSVQLLDILQKLTFVQEIEIVKQLQDVLDALFGVLVHKSGESKFEDLIFNDIVWVLGIVHDRRYNLGPLVEQYTESHFRSPYAASCLIRSFTRLLQSVSDPQSARDMRALFKVGRTFMKIVITSYQQRRFGSQTNEKGDEKHSNFKQDMQAILFGLQMMMRSETAALVGSKTLLVREFHTWLPELLPAFSKEEVIRTSIDFIDSCEDATGKLVLYRLILILNYTKLDRIWTEDRDKKMLVKNCVRWLSPYWTQNDLSDDWHEQVRLSCSIVAELTRFPTHYLHEFVPKLISAYEAIARQPSTRRRSLSFLFPDSYPFVSKATDCEDSFDETLLELSATVATIAKLKAPLSPKMHGQELSNYVLSTLSMLRSLLQHNACPSTWLSLHIYHHSSALTILNYLSNLLISQYLPSPEEAENPDQADSFNLKMSLWKSFLDTLLMLVSSPALALELFPEQKRRAVWKISGDVRQSGADLLRNCWESLGWEASADDQRRYNIRKLGGYQVQYVPSLVAPTITLCLSMHEGLRRVAVEILQTMIVNEWALSDGESLELIETEVIGALNSIIKAKPVSANEAMSRKIFIAELLDLFSTIANQPDDALWTAIEDLVATIDELIDLLTTTEADEEVDDHPRDMSNGHARGQSGDSQNSEAKELARARRSIDGLTPTSPAQGRDKEYGVHALECYKQLAEEYERNGDYKRLAKTYRAIARIHEARAASRAGPGGPINGRQAYGEHDADGEEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKB2</accession>
    <name>A0A0D1YKB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05462</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235632.1">
        <property type="nucleotide sequence ID" value="XM_016379805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKB2"/>
    <dbReference type="STRING" id="91928.A0A0D1YKB2"/>
    <dbReference type="GeneID" id="27332545"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05462"/>
    <dbReference type="HOGENOM" id="CLU_000604_57_7_1"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001305">
        <property type="entry name" value="ABCG transporter ABC superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF98">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="43"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW15416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="400" mass="43962" checksum="2CA92ADD3A3F953C" modified="2015-04-29" version="1">MSQQDTTPHSGDSSNAVDTGLDLEKGRGLGRHLTNTVVTSFSWEAVNVTVKDRKSGLPLKILDSNHGSVKGGSVLALMGPSGSGKTTLLNVLAHRTSTMKGDFEGNIMINGQVTNQQSIRKVSSYVEQEDAMIGILTTQETVDFAARLSLQGTMSKKERVARVNELIESFGLQRQRGTIVGTPLRKGLSGGQKRRLSVASQLVTSPRILFLDEPTSGLDSAASFEVMNYIKKIAKEYNIICIASIHQPSTTTFDLFDQLMLLSEGRMCYFGALAGIHAYFNRINRPIPVHINPAEFLLDLVNGDFSQARNNDSSHNELKYIQDSWSSSTECRKAINECSSISATETSLSKLQSSHHNVLALSWILLHRNFIKSYRDFIAYGTRVAMYFGLAIMMGMPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKG5</accession>
    <name>A0A0D1YKG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235682.1">
        <property type="nucleotide sequence ID" value="XM_016379855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKG5"/>
    <dbReference type="STRING" id="91928.A0A0D1YKG5"/>
    <dbReference type="GeneID" id="27332595"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05512"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_4_1"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="54807" checksum="3F5CDC585C9E27FB" modified="2015-04-29" version="1">MALGWPVVGLVEVSLAVFLSIWWAAYRTNFSRISNLSEAPGSFPFVGHLLSLGGRLGVNDANVFSRWSGELASGIYQIKLGYQRTVIVSSWAATEELFVFKNRSILDRVQQHGFSDYIGLDISGSSLTSDVKKCRAAAFGALGKPMWPGYYKLIEPESVKIITRIYESGRNGQVPLETYPWLRQMMFNLALHMTYGIQEGDFDDEELSNRLLNSLSVITECRGSTAEYRHYVPLLRAWWPLSKSKLIAAAEQRNACAQVLHEQYRLKAEQEQAPDCLLSSLSAERLTPDELFGTCMSIVQAAPDTVSSSTYQCMAWLCSAQGQDKAFREEKAPLLFSLYKETLRFYATSAFNMRRTSKDVTVGHAAAAAVLPKGVGVTMNIRGVNHDPEHYGPDALTFNPERFLNDTSPLPHLTFGTGSCICPAYMIANRIIYSTLLRLILAFRLKQVQGTRLPSLGRLDFSDVMGLIAVPRVFDCAFTARDAAWLKTKLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YLZ0</accession>
    <name>A0A0D1YLZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_06052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236217.1">
        <property type="nucleotide sequence ID" value="XM_016380390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YLZ0"/>
    <dbReference type="STRING" id="91928.A0A0D1YLZ0"/>
    <dbReference type="GeneID" id="27333135"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06052"/>
    <dbReference type="HOGENOM" id="CLU_1643724_0_0_1"/>
    <dbReference type="OrthoDB" id="4119926at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="161" mass="17891" checksum="3CBF116D92EE072B" modified="2015-04-29" version="1">MKGQFFFRPDGPCRTPAQPILYCDIESECLERYRPGGYHPVNVGDTVSVGEFKYSKDLLRFRQNNMMVSAIRASLLTPFSTMAPMADIDARPGSQITESFPRRIVEPATFPISDVAGQVHATLIDFEQAFLRTDQSLAHVPYPVDFQSSRDAAGIDMGPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMI9</accession>
    <name>A0A0D1YMI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_06307</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236472.1">
        <property type="nucleotide sequence ID" value="XM_016380645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMI9"/>
    <dbReference type="STRING" id="91928.A0A0D1YMI9"/>
    <dbReference type="GeneID" id="27333390"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06307"/>
    <dbReference type="HOGENOM" id="CLU_003041_13_0_1"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="199"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="462"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="77"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="651"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW16256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="732" mass="80657" checksum="20CFC9B6667F941E" modified="2015-04-29" version="1">MSKRKVAPGEQAARKKQKLPEPTKQGTVKSSTVRGDSLKWKEVSLPGRLEDAEGFFGLEEIDDVEVVRDESTNAVMFRPKSQEAVLEDANEDIDGEEWGGFDDESQTQPLSEEVKSVPVSANTKTPKQTDPSNKTQTQKPKQQATDVQPGLGFDVLEETTDDLKTDVSAWKGLELHPTTLSQLARMGFAKPTPIQETAIPAIKQGHDVIGKAVTGSGKTLAFGLPIFENWLSTAAATSNAPKKPKDSILALILAPTRELALQLHKHLNELCMGLENHPSVTAVTGGLSIIKQQRQLGYADIVVATPGRLWEVMNDTSAHHDPDVFMDRLKAIKYLVVDEADRLLSEGHFKEVENILDALDREVVDEEATERQAVKGSQKSQRQTLVFSATFHKGLQQKLTAKVKPGKRMSDQLLNNQQSMEYLLRKLSFREAKPTFIDVNPETQMATALSESIVECAAMKKDLYLYALLMQNATAKTLVFTNSISAVRRLVTFLQTLKQPAVGLHSTMPQKSRLRSLEKFAAQRTVLVATDVAARGLDIKGIQLIIHYHVPRTADMYVHRSGRTARAENSGRSILLCSPDEVAGVTRLIAEVHKSDKAPDVVDLDGRLVKRLADRVDLAHKISDATIAKEKTNSKDEWLRTAAEELGVEYDSEEFESQGQKGRRGRGGGKAKKEKEKAATGKDQISQWRAALQDLLDKRVNLGVSERYLAGGRVDVDALLSGKADGAFLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YND4</accession>
    <name>A0A0D1YND4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236792.1">
        <property type="nucleotide sequence ID" value="XM_016378115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YND4"/>
    <dbReference type="STRING" id="91928.A0A0D1YND4"/>
    <dbReference type="GeneID" id="27330847"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03764"/>
    <dbReference type="HOGENOM" id="CLU_035244_1_0_1"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="351" mass="38589" checksum="7FF6F0611ABF635E" modified="2015-04-29" version="1">MTDSIAPEDPQEKPVTVEEESPVPADGRKRAKVKRHCGRFWWIYTIIFIVVVLVVVLPIVYVAYPHKAQSAINKSTLLVTSQALLNPAPDHFDLDLNSIFLSNSSLHAKLDPFLADLCLEDSEIPFAQLSIPAIEAANGTHEHVSQTVQIKNKDQFYDYARTQLASEEYTVYLKGKGGLKYGGLPKTTVKYNDKIVLKGLNGLEGFNVTDFNLIMTAHPDNYNSNGTVLIPNPSVTTYEMGNMTMDMYVGNVSIGNSTLENVVLRPGNNSIPLLALTNQTAVGLLLFTNYKSGIFPIEIVNRGVVSNGQHLPYYEQPLQAKNLTVKLNVIDVLERAGLAQALGINTTSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPD2</accession>
    <name>A0A0D1YPD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xanthine/uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_04197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237222.1">
        <property type="nucleotide sequence ID" value="XM_016378545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPD2"/>
    <dbReference type="STRING" id="91928.A0A0D1YPD2"/>
    <dbReference type="GeneID" id="27331280"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04197"/>
    <dbReference type="HOGENOM" id="CLU_024508_3_2_1"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="61180" checksum="33C713C048BA4773" modified="2015-04-29" version="1">MGFNEWIHNANLAVARSFVGKRFRLDGSGHARERKGTYFFTEIRAGLATFFAMAYIISVNATIVSQSGGTCVCPPDSPDLCDSDPEYMLCVAGVQRDLVTATAAISALTTFCMGLFANMPIALAPGMGLNAYFAYTVVGYHGSGLVPYQVAVTAVFVEGFVFVGLTVLGLRQWLARAIPASIKLATGVGIGLYLTLIGLTYSAGIGAVVGAQATPLELAGCKPEFRDEAGMCPTADRMRNPTMWIGIFCGGFLTVMLMMFRVKGAIIFGILLVVTFHPIEKILVVQEWDISGYGGQFGLAFITFLYVDILDCTGTLYSMARFAGAIDEKTQDFEGSAVAYLVDAFGISIGALFGTPPVTAYIESGAGISEGGGTGLTAMTTGLCFFISIFFAPIFASIPPYATGCVLIIVGSLMAKAAKDINWRYIGDSIPAFLTIAIMPFTYSIAYGLIAGIISYMVINTLVWIIEKASGGRIKPADKEYKDPWTYKIEGGVLPPWVTRAARGKKDFWRPYEDVEHNTGAAPAGGAPGMTLEGKEGGSTSIGAAETMAAAGAPERGGFGHKGSSTTSGSEEGEKVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPN5</accession>
    <name>A0A0D1YPN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237387.1">
        <property type="nucleotide sequence ID" value="XM_016378710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPN5"/>
    <dbReference type="STRING" id="91928.A0A0D1YPN5"/>
    <dbReference type="GeneID" id="27331445"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04362"/>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000624">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19304" checksum="B0A828B03D31730B" modified="2015-04-29" version="1">MGGLVSKYLSNLIWGKKAIRILILGLDNAGKTTLLYRLKIGEVVTTIPTVGFNVESVQYGSLNFDVWDLGGQTSIRPYWRSYYANTAAVIFVIDSTDIERLEIAADELRSMLNEDELRDAALLVFANKQDQPGAQGAGEISEALKLSELRDRNWSIVACSVIDGKGITEGMDWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPR8</accession>
    <name>A0A0D1YPR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237427.1">
        <property type="nucleotide sequence ID" value="XM_016378750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPR8"/>
    <dbReference type="GeneID" id="27331485"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04402"/>
    <dbReference type="HOGENOM" id="CLU_033551_0_0_1"/>
    <dbReference type="OrthoDB" id="5552418at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="394" mass="43460" checksum="2C5CB229B8304E46" modified="2015-04-29" version="1">MDGNDRRRTQYGQPYQTPTQPRPLPGQPMGPPSSDRYGQATGPARSDAGSSAITPRPYVPSYPGYAFHEQQYGTSQMQGSSPMQGVQMQYSPAYIQEASRQGSITPSPSQQQQQQQQQHQYGQYGQGTMLPPVGGQSMYDNISYQQRQALEVMASQFAVPQYMPPSDQAALAGVGPSPSQYLTTQAEQSVYGNVPVTRAPVLPTYPSRQMDFPEATQHQQQPSESGAARDSKQEALQEGLRDYRQQIRSVFDSIISGRVNEASEKVLAATRWLASSVDALGLHHDDESNHLERIQLWTELNLCWEALGQKQKEVTEEALRTTRLSGDMLSSEKITSLIDELISMCDQLEQYGLVDFEMGIWEEQIIHIFTVCLDLLPGGGTGSGGDRQQAGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YS00</accession>
    <name>A0A0D1YS00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW17996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238212.1">
        <property type="nucleotide sequence ID" value="XM_016376642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YS00"/>
    <dbReference type="STRING" id="91928.A0A0D1YS00"/>
    <dbReference type="GeneID" id="27329365"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02282"/>
    <dbReference type="HOGENOM" id="CLU_010194_13_0_1"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF33">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="281" mass="30325" checksum="20028C4827353626" modified="2015-04-29" version="1">MSKVALVTGGSSGIGLALTKHLLTKAWNVVIADITPPQEDAGLPTERTLYVRTDVSSFNEQARLFSKAFKWHGKLDFAALNAGIDDRDDIFGTIDPSTAPTKPDMSTFDVNLSAVYFGIKLFAHYAAQNPVPGGKIVATSSAAGLYPNPGIPQYTAAKHGVIGLVRSLAPAAACHNITINAVCPALVVTNLDPSLSQRFPERLRTEMSVVMKAFDELTDESLGYTGQAIEACAEGLYCREVGEPEAPSMKELQHSQTGREWMESLVQKNIQRVLRTPGKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSP9</accession>
    <name>A0A0D1YSP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_02584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238512.1">
        <property type="nucleotide sequence ID" value="XM_016376942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YSP9"/>
    <dbReference type="STRING" id="91928.A0A0D1YSP9"/>
    <dbReference type="GeneID" id="27329667"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02584"/>
    <dbReference type="HOGENOM" id="CLU_019048_3_0_1"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="131"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="484"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW18296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="544" mass="60599" checksum="68CBF80C903CA6D6" modified="2015-04-29" version="1">MTTTMTETPELRHGAHHRSLSPLKGTRESTSRERFPSFDDALPKFTFNPGAPVVAESPLEVTTGPLSNPEIKWPTRRESQRLRNGRSPVIHGHRPRRSLSDAINNFRARRGSVSENAQELAEALRAPVSYKLIALCIVWYMTSALTNTSSKSILNAFPKPATLTIVQFASVSFWCLVLTGLSSTFPSLKRSVPALRNGLRKPSWEVLATAFPLSIFQLLGHLLSSYATSKIPVSLVHTIKGLSPLFTVLAYRIVFRIRYKRATYLSLVPLTLGVMMACSTDFSSNFWGISAALVAALVFVSQNIFSKKLFTEASRAEADGQTHLPRKLDKLNLLCYCSVGAFLLSAPVWIYTEGFELIEELWKDGFIGLSTKRNALDHGGLMLEFIFNGVSHFFQNIMAFVLLSMLSPVSYSVASLIKRVWVIVLAVVWFRSSTTSMQAVGILLTCVGLYLYDRTSMEDAAERRTKSDHFRHKTALLPVTEVNTPGLQLSNPMDLNHRSEMSDSHPKRDDSRGRTHESPFASGWLPPGTKQESTWEAAERNAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSY1</accession>
    <name>A0A0D1YSY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238617.1">
        <property type="nucleotide sequence ID" value="XM_016377047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YSY1"/>
    <dbReference type="STRING" id="91928.A0A0D1YSY1"/>
    <dbReference type="GeneID" id="27329772"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02689"/>
    <dbReference type="HOGENOM" id="CLU_005619_1_0_1"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="816"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="757"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1088" mass="121038" checksum="39B6CCD99897A449" modified="2015-04-29" version="1">MRTLDIYDHVALKDDSRLCGTITRTNGDPGDLHMENELIIGHSTVSPDALNEFVTTSVPPVGHVFVRWAAEIHGGSLVDENDLILLSRSFQIGDVVKQDASGMTGTVIDVDENYTLEPIASCDVQVFKLLSLEPEIPSCTPACASRPPHPFFHPNPHALICNVPSREIKTAQDVVKGEYLTCNNWIGLVDDVEYLVVIGLENKSIVAVAGFHGIHRPIPDHGKPLITLPEFDGFRKPDFVVAKQGWSTMIPVGSLRPGEMVVADRSRLREGRWIRGSYDPKSSGHGVVLDVRARDVAMEWISNNKGGERSSSTAPIPRYEQMIYHNVDHFQDPASLIPNKNVTVYDFPKMPGKAPTVALNSRSPPEHQPDTRRVFPGQDFIVGAHVKFRDPTGAAVKYQGIDEDNSHGRLVKVVSRNFPDWDFNEFIVVNMTQKATVLWQDGSTTTSDSLNLQDHGLFEPELQPADIVLMREEMRQRPVGIRDGRNLKTSDFNEVALFERPHDLIPLKVGVIQIVEPRERVATVRWYQKPKIELWASGSILAPGSHFGPIGDTVTDVSLYEILSFPALNWRKKDMCILANSEEIMRRRQAYEAGQGVDAGRPRHTTSLRGAIERELAPLAPLPARTPATRARPIDAGPQDVDWVGQVVANGLDGSLTVRLGAAQNCRDVQTDPDGIIAVIDERDGVFDDGDMMDVDSSDEYDFGFDDWSDDSYVEPISESVEYEGGERLDHDEGDENWVSEEDDYFTDAEMEVRDAEDVQMNEPNSPPAGEETLNHPPHAPLSSVIPLEPPPQFLLLDEEPPSDQFGLHSPPSSLALLKRISKEHKILASSLPKGEIYVRTYESRLDLLRCLIIGPRDTPYENAPFLVDLHLPERFPESPPTAHFHSWTSGMGRINPNLYEEGKICLSLLGTWSGKHETESWSEKATILQVLVSLQGLVLVRNPFYNEAGFEGLENDAKYIHDAEQYSEKAFVIARRFVKHALLRPPKGVADILAWLYLPQNSEKPSERLLGTIVNQGKLLIERSESARARNDESLLDSQGGKDDATKVFLRPLSRGGVVMLRRVIEELQAELDKLKSLDGGAGEAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YT41</accession>
    <name>A0A0D1YT41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02744</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238672.1">
        <property type="nucleotide sequence ID" value="XM_016377102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YT41"/>
    <dbReference type="GeneID" id="27329827"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02744"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="8"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="495" mass="54135" checksum="7A3EF9B7FB935947" modified="2015-04-29" version="1">MRKYNLYCSIFATTGSLIYGYDSGIISTTLGQKAFPAYFNYPSDNLTGAIVSTYSGGQGIGNLAGGYLGDKLGRKKTIWLASTLALIGAILQTAAVNIPMFLVGRILAGFAIGLVYAVASIYNAEIAPPKIRGVMVAMQTLLIAGGYALSNWVGVFGSFARGNASWRIPLGVQCVPAIVLIVGLYWLPESPRWLLQNGREAEAHAVVKRLHGDEGGDSTFADREFNQMKQQIDYEREVTIRSWTQLFIKPSNRRRLILGILLQVFLQTTGVNVVNYYQTQIFGSIGIEGRNVLWVSAGFGMVGVISTAICLTYIDKTGRKKPLAWVSVGLTIDMILLMVFSKYYANSDNKVGQGFTIAWIFIFSFIFSLGYNPIQLVYIAEIFPTALRSRATAICAFMGTGTGLLFNQLSPKAFAHIGWRYYAVFVVCDAIAALSFFTIFPETKGKTLEEIAEVFGDDVAFTEYVGAPGDAVVQKQSGLGEADADQIEHHNIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVG1</accession>
    <name>A0A0D1YVG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239502.1">
        <property type="nucleotide sequence ID" value="XM_016377932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVG1"/>
    <dbReference type="STRING" id="91928.A0A0D1YVG1"/>
    <dbReference type="GeneID" id="27330663"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03580"/>
    <dbReference type="HOGENOM" id="CLU_015737_0_0_1"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="121"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="382" mass="42196" checksum="49EC649DB942B90A" modified="2015-04-29" version="1">MPWRRLQNLQAVRGLVTPPPCYGERHQCLPRGFLQVRHESSTSKPAGTPEPYPSSYSSSSPPSSAPSSSSSQHHSGSRATEDNASPSSREEKAIDPRLPELGRLIQDDYAAFKTHYSTPRYPIVLAHGLLGFDEWRVAGPYLPSIHYWRGIKDAFARNGIECITTTVPRTGSIETRAAALSSQITQHARGRSVNIVAHSMGGLDARYLISRLCPLTFRVRSLTTVATPHRGSSAADMLFRDIGPDLLPRLYAVLDRLHVDSGAFAQLTTAYVNDHFNRVVPNDPDVQYFSFGATASPHLLSVFRLSHDLMELVEGPNDGLVSVRSSRWGEYMGTLDGVTHLDLINWTNRIKRLAARLGIVTERFNAVAFYLGVADMLAKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZZ7</accession>
    <name>A0A0D1YZZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_01470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241107.1">
        <property type="nucleotide sequence ID" value="XM_016375831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZZ7"/>
    <dbReference type="STRING" id="91928.A0A0D1YZZ7"/>
    <dbReference type="GeneID" id="27328553"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01470"/>
    <dbReference type="HOGENOM" id="CLU_080796_0_0_1"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW20891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="203" mass="23964" checksum="BCF78E56B9A6C37F" modified="2015-04-29" version="1">MGALKYVEELHKKKQSDVLRFLLRVRCWELRQLKVIHRASRPSRPDKARRLGYKAKQGYVIYRVRVRRGGRKRPVPKGATYGKPTNQGVNQLKYQRSLKSTAEERVGRRCANLRVLNSYWVNQDSTYKYYEVILVDPQHKAIRKDPRINWIVNPVHKHRESRGLTATGKKSRGLGKGHGYNKTTAGRRKTWKRLNTLSLWRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0Z8</accession>
    <name>A0A0D1Z0Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241547.1">
        <property type="nucleotide sequence ID" value="XM_016376271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0Z8"/>
    <dbReference type="GeneID" id="27328994"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01911"/>
    <dbReference type="HOGENOM" id="CLU_2849706_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="65" mass="7018" checksum="8D6080C1C9315D7A" modified="2015-04-29" version="1">MSSGETDTSQTPQTSSESEKSQQQQQQPQATSTESSETSTMAKLPADVVKTSISKVDEIILRISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z1S7</accession>
    <name>A0A0D1Z1S7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241822.1">
        <property type="nucleotide sequence ID" value="XM_016376546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z1S7"/>
    <dbReference type="STRING" id="91928.A0A0D1Z1S7"/>
    <dbReference type="GeneID" id="27329269"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02186"/>
    <dbReference type="HOGENOM" id="CLU_042555_4_1_1"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000045">
        <property type="entry name" value="Glutamine amidotransferase DUG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="413" mass="45338" checksum="DA1F082F4AA2E601" modified="2015-04-29" version="1">MCRFMVYKGSEPIILSKLITEPSHSILTQSYDSRLRLDSRRPVNGDGFGVGWYTEPELGPDPCIFTSTLPAWNCVNLERIAPKTASRLVFAHVRATTEGSLAENNCHPFQHNTLMWMHNGNIGAWKYVKRPLADSLSDKWFLGVKGGTDSEWAFALFLDTLEKDGVDPSSEPKDGFDTKLLRRAMKKTIAKINAFVKAVPAEHQLDDVETRSLLNFAVTDGHSVIVTRYVSSKTDAAASLYYSSGTAWVEGKTKGQFRMERRDKASDVVLVASEPLTFERHNWLSVPTNTIVAICKQTVYVRPIKDEFYDPDPSTERSTGFARSKGLVSKAPGGGTITPSTIPGTPVPRNEVETAGGGFIVKDDLDRVRSNMEDFSLRTGSGGLLPNDHISACQARRVGMKGAVPNGPIPAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAG6</accession>
    <name>A0A0D1ZAG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230198.1">
        <property type="nucleotide sequence ID" value="XM_016386066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAG6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAG6"/>
    <dbReference type="GeneID" id="27338841"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11758"/>
    <dbReference type="HOGENOM" id="CLU_407086_0_0_1"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="75208" checksum="2F920F42D7D6CFD1" modified="2015-04-29" version="1">MAEGRPSSQGRRDIVTDRGRGSTSAEPDDESESGASSAPKYRRVNRHGTRAVTASDQSSRFLFVDSSSAGQRPRSDQRAINAHIQQSAYRNRRQAARQQRGSDAANVGRHRGSTQLQPRRIEPSPSVEHHRASPLTSPTRQEPSDSRLPTPTSTISPTPSPGLATNARAVADVDQDLISRLRYYSNVRGSEVRQAVEAQREDDRRASSEHRQPAPLQEDRALAENVSVRSMLTQILQRLDAASVGQPLHGPPISALRNSVLDPFSTSSIMVTPSMDAVLRHFSDVMIPSVFPTRQQAEIQTRWAFEKASQEPLVLYSLLAISSAERDARLGQLRSGSQETTFTEEDLKNRPVPDFVSYKVNAVKLANETMKSIETAAKASTIFAMMCLLSIEVITGNQKEIFAHVSGLQKLIAWRGGYHGIPPHATELILSTSYMCAAMTRTLPASPPTSTLASLPPNLIEDINRNLADDTRQMGTGILTPEVDTILDWRISQAFRDMTEVVRYREYYHEKQMQPGEEEVDYINAKSYQFRYAVLSAPFEPRAPTSDKEEACRLALLIFWFTNYQMSQPDSALNRTLTTQLKSALQVSDLKGLWGPYHELLAWVLLLGAFISAGQRERPWFVLNLAKVCKVLRLQGWTDVRSVLVKYFYLDRIYAKGMQASWEEAAMIAETME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAK7</accession>
    <name>A0A0D1ZAK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230223.1">
        <property type="nucleotide sequence ID" value="XM_016386091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAK7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAK7"/>
    <dbReference type="GeneID" id="27338866"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11783"/>
    <dbReference type="HOGENOM" id="CLU_027207_0_0_1"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22699">
        <property type="entry name" value="FHA_PLM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="108"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="496" mass="54262" checksum="64832D020CEE8BD0" modified="2015-04-29" version="1">MAPSTTLSETTDSHTPAAKRPAMSLLPAFEPLSSSPALPRPLKRSREIFEPATYPTPVPTSSTHILSSSPSRIPNAGVDPARPSSTLSERTPLGTVPSIQLSVEGKVTRMGRSSASCNYQLSANRLISRVHVEACYKGASSRLERERVEITCTGWNGIKIHCKGRVYEVKKGETFSSDVRDAEIMVDVHDSRVVIQWPPKQRLGAISSDEEDEEASPTKRQRVMLRHSTPPSPSPLQTRRQPVSPVSPSPAVQALLPSSPPLGTSRILETVEIYEDPEPAQETNNTVDAAQVSQATQALTESVQNPTINQTAVSSISEDFSDNDEENDPIIHSFGPFGANLLPRMASFTAGDSPTPADSNKSSRSSHTEPLHPNPGPAVIKKELPKVDIRGHIINQLAFSRLSSTPWSIILSHLPSEAGSLSINEIKQAVRETPCIGEVAREGKDAAGKPLESELYYIPDLDEDEKRREAVVNDLRKPGLRACRKQHKQYFWRKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZB05</accession>
    <name>A0A0D1ZB05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial resolvase Ydc2 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230413.1">
        <property type="nucleotide sequence ID" value="XM_016385469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZB05"/>
    <dbReference type="STRING" id="91928.A0A0D1ZB05"/>
    <dbReference type="GeneID" id="27338241"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11158"/>
    <dbReference type="HOGENOM" id="CLU_042191_0_0_1"/>
    <dbReference type="OrthoDB" id="5552842at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16963">
        <property type="entry name" value="CCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial resolvase Ydc2 catalytic" evidence="1">
        <location>
            <begin position="56"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="325" mass="36397" checksum="6DC7EB885DD6647F" modified="2015-04-29" version="1">MPGQKHWLEALTLEKLHRLAVTIGSPCSGTKAIRVDGIRNAVKNRQRYNEGQLSLLSIDMGIRNLAYAHFIATKAQAAKPTLQAWNRLSVSKPAEGFTNGSPPSDGVQQGDMRAATSPLLDSTIKESFEPDEFARHSYILIKHMLQTYKPDVVLIERQRFRSGGRAAVPEWTIRVGVFEGMLYAVLRTLVERDKLKLDVQPMLPTRVNRYWLEGPDSTVGPSKKRATGREVKSAKIDIVGRILEDRSQASKVDVSTALRPFAQQFVSVWKKEVRGKKGHGNEISKLDDLADCFLQGLAWIHWQNNRQRLDSSGADAVDPESGWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZB24</accession>
    <name>A0A0D1ZB24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_11178</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230433.1">
        <property type="nucleotide sequence ID" value="XM_016385489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZB24"/>
    <dbReference type="STRING" id="91928.A0A0D1ZB24"/>
    <dbReference type="GeneID" id="27338261"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11178"/>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF41">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252655" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW10217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="456" mass="49370" checksum="478A330D0C024E3F" modified="2015-04-29" version="1">MKPFRRRSAESSLAVAILLCIQQIQAITLDLQNPDSIKAASKIVADEMVSYYTGYRPGDVPGNLPAPYYWWEAGAMFGALIDYWYFTGDDTHNAITTQAMLHQVGPQNDFMPPNQTKTEGNDDQSFWGMAALSAAEDNFPNPSADQPQWLALAQAVFNTQAARWDTSSCGGGLKWQIFSFNGGYNYKNTISNGCFFNMGARLAVYTNNQTYADWADRMWNWCSAIGLMDDQYFFYDGSDDLLNCTKLDHLQWTYNAGTFLVGAANMYNYTDGSPVWEARINGIISGITKIFLKDNVIYEQACEPVGTCNIDQRSFKAYLARWIAATIVRAPFTYDQLKPILEASAQAAAASCTGGDGGASCGLQWTTGAFDGSTGVGEQMSALEVIQSNLISVSAGPVTEGSGGTSKGDPSAGTTSDIGPGDLHAEPLTTADRAGAAILTVLICLVIIGGAWWMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZDM9</accession>
    <name>A0A0D1ZDM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10391</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231308.1">
        <property type="nucleotide sequence ID" value="XM_016384706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZDM9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZDM9"/>
    <dbReference type="GeneID" id="27337474"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10391"/>
    <dbReference type="HOGENOM" id="CLU_126658_1_0_1"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="158" mass="18083" checksum="189B6CACA6117DC1" modified="2015-04-29" version="1">MSKEDGAESRIKSRTSSTEPEDNSNAGEPGSGSRKNSKVTKPRLTEDQRNFNHKDAENKRRTAIRERFIELSRMVPGTLGQEKSEQVMLSKTADYLREMMEEQRNLEALADSRGIHIDDAGRLKDEDYGGPRWKQPNMEQYEASKQRKGGSNEYEEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIV0</accession>
    <name>A0A0D1ZIV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="5 20">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PV08_07979</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of Ku70 and Ku80.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the ku80 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5 20"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233008.1">
        <property type="nucleotide sequence ID" value="XM_016382305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIV0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZIV0"/>
    <dbReference type="GeneID" id="27335062"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07979"/>
    <dbReference type="HOGENOM" id="CLU_010975_1_1_1"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000073">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016570">
        <property type="entry name" value="Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16 20" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="VWFA" evidence="21">
        <location>
            <begin position="6"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR016570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KIW12792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="699" mass="79142" checksum="77B2D2E2423FE7D0" modified="2015-04-29" version="1">MAEKEATVYLIDVSRSMSKKHSGRSQTDLDWALQYVWDKITNAVFTGRKTLMIGVIGLGTDGTNNDMASQDDSYKHISVLQPISQILMPELRTLPKLLKPSKTDDRDVLSGIIIAVDMMMKHCKHLKYKKRIVVITNATGHIDADDVESTAEQFKNHDIELVLLGIDFDDPEYGTKEEDKSATKAENERTLQKLVDLSGGMFGTMQEAIDQLSRPDIKPIRATPTYRGQLRLGDPEHYDTALSIDVERYFKVQTRRPPTASSFAVRENVADDDQGLQSVHSIYKYAAKLENGETKELSREELAKGYEYGRTAVAIMESEQNITKLETSMGYDILGFIPMEHVERYMLLDNSNVIVAQRGNDKAALALSSLVHALFELGSVAVGRLVKKDMQDPILTLLSPLVDADLECLVENVLPFAEDVRSYRFPPLDKVLTVSGKELTEHRNLPNQKLMMSMSDFVDNMTLMNEDEEMMAMEDTFSPVLHRVEGAIKFRAIHGSDKFPEEPEMFKTYRQQPEELQERSKKALSKLIEAADVKKVQQRAKGRRRYRDAEKPISGLDVSELLRKEKRDHISPDNAIPEFTQMIETADDEGYIATIVQQMATILTDWIRTSYGERNYGKVAEGLGTVRQWMQELEMPDLYNNMIQDLKEKILSKQLGGDRALMWFQVRKNKLGLISTDDCSSSQITVEAARSFLDPKSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZLN2</accession>
    <name>A0A0D1ZLN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233963.1">
        <property type="nucleotide sequence ID" value="XM_016383260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZLN2"/>
    <dbReference type="GeneID" id="27336021"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08938"/>
    <dbReference type="HOGENOM" id="CLU_085117_0_0_1"/>
    <dbReference type="OrthoDB" id="4159272at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31800" checksum="C1955FA3E3BC7D2F" modified="2015-04-29" version="1">MLLWSPMAYKYRAVRPLDRSAIANLALSFQTTLSDYLFLDRLVDSGVMPSPWTGLNERKLLLCIIDQKNTFKWQHIAQSMGPQFSAEACRFHTKLTARMPYQWTPERERRMLLVAIASANLKPSADTWTKVSQLLGGGLTPSAVSQKYYKLRNEFAKLPDGGQPPSSSPTSTSTSSSTPSTPTKRKVSDSDGSEEEEEPKKPTPPSKRARKTKREALDGVPFSNSSGSFTSGIREEDMAAKVMTMTPGNMFEQQQPYNMHEQFFIPVNMPAEEDNARGVNNGFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZW53</accession>
    <name>A0A0D1ZW53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237133.1">
        <property type="nucleotide sequence ID" value="XM_016378456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZW53"/>
    <dbReference type="STRING" id="91928.A0A0D1ZW53"/>
    <dbReference type="GeneID" id="27331190"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04107"/>
    <dbReference type="HOGENOM" id="CLU_000288_144_6_1"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF4">
        <property type="entry name" value="SERINE HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="21"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="604" mass="66726" checksum="FCA963DC7840DFBA" modified="2015-04-29" version="1">MEHDNNLRRKDTTKGPPLRILSLDGGGVRGYSMLVILQELMHRVYVESEGKPPSREATPKPCDYFDLIVGTGTGGLIAIMLGRLRLDLETCMSVYVRMTKRVFETDKTIAGIPYKHTLFKASKLEEAIRECVRDHTVFEDEGNDGTAEGGREFGDLSSPISTAGAIPPRRSMSIRSNNSMSMSSPSGVRNSIISPTFNGWGNPNASLYDGRENRTKTAVTAVFKDTPKNGSSVLLRSYDSRKEPPPEVNCTIWQAGRATCATGLAFKPIQIGQSVFIDDGAGQYNPAVTALDETLSEWPAREIGVFVSVGTGKRPENSGVPEHEWWEDFLGGSMGMFAEARRRLIAKIEACEVTHQQMIKTELPKRGVPREVYYRFNATSSVGSVGMNEWAAVSTIQTNTRKYLRQDDTQRLLGDAALKMGKIEIMKRRYERGDTHTRGSSWSYRQKPQPPAPPVAPAHPGAIELPAQDASSYTPTQHPRIPGMPPYPNDEYASSQDKFSLLPGDTNSSRVSGDLPYRGARDEKNVYQPPPVSSLPAHNYNPSEPPPRPPKTPIDDHAFPVRQRTSPMATGRTNGVPRPPYPLDYDAGPPPMVSKLRKPEYIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZXQ0</accession>
    <name>A0A0D1ZXQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237648.1">
        <property type="nucleotide sequence ID" value="XM_016378971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZXQ0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZXQ0"/>
    <dbReference type="GeneID" id="27331709"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04626"/>
    <dbReference type="HOGENOM" id="CLU_008871_0_1_1"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF17">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="5">
        <location>
            <begin position="485"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="4">
        <location>
            <begin position="622"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="6">
        <location>
            <begin position="771"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="824" mass="91662" checksum="74A5209E2BE702F0" modified="2015-04-29" version="1">MSPKEPPLILPVEHGSHSTPSRPMMTPTTEPALEERLFHPDASIVLIGIRASGKRSLGFIAATALGRRFVTEDHYFQSFNGLSRQEYLRIHGSEQFHRQDIATSKRMLEENRYGCVIDCGLGSLTSSLQDYLRLLCQTNPVVFILRDMDRIQALLNLDDRSAKLLENGNSTHRKCSNYEYFNLEDDSMARSTELDDADRASPNYSFKLRHAQADFSSFVRLITGTRAQQSSNDSPFSLAVPIEQRTYTHALEVKLSTYMDGQIDFAALESAGDITEIYVDVWNSTAMRSLSKLVGMARRALDLPILLSVTTTLADASSNTYLDILRHGFRLGVEYLSVNLELDDHTLAHIKAMKGYTKLVATYTPKTPTKQGWKDRIWRTMLDRAAAEGFTMIRFLNVPKSRLDNDSLIWFLEETRNIQPKPIISAFNIGGLGRTSQILNPTLTSVTHPSLPRPQLPQFQPLLSSKEITGALFDIHVFDSLKFYVLGANVSGSLSPAMHNAAYAFHGLRHSCMTKNITSWQDAEELAKDDSLCGLSIVQPYKVKIFSHLSLCSGHARAIGAVNTIVPLRADTSGNVPAVEIQAQERNRAGVIKGWYGENTDFRGIMTCVNRSLSPRNAIQPKSTALVVGAGGMARAAVYAMLQLGCKNIFMYNRTLSNTRVVANHFNDWARSQVKANGSGLTPSNPVKVLDSTSEEWPSGFFPPTIVVSCVTHELLDGRPGADFELPESWMQSPSGGVILEMAYMTKETPLVKQMKSFRELTGRPWVIVGGIDALIEQALVQFETLTGRKAPKRYMAKAAWDTIHQNTSYLVDGQQYFSDRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZY82</accession>
    <name>A0A0D1ZY82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237818.1">
        <property type="nucleotide sequence ID" value="XM_016379141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZY82"/>
    <dbReference type="STRING" id="91928.A0A0D1ZY82"/>
    <dbReference type="GeneID" id="27331880"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04797"/>
    <dbReference type="HOGENOM" id="CLU_152057_2_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9197" checksum="D5F3B323C8284CC3" modified="2015-04-29" version="1">MPSETTDIKQFLEIARRKDAKGARLMKSSKSKDIKMKIRCKRYLYTLILKDSDKADKIKQSLPPSKSPSSLGRILCPVASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3U7</accession>
    <name>A0A0D2A3U7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239723.1">
        <property type="nucleotide sequence ID" value="XM_016374447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3U7"/>
    <dbReference type="STRING" id="91928.A0A0D2A3U7"/>
    <dbReference type="GeneID" id="27327162"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00079"/>
    <dbReference type="HOGENOM" id="CLU_037457_0_0_1"/>
    <dbReference type="OrthoDB" id="3254104at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="317" mass="34533" checksum="B42A48189119B523" modified="2015-04-29" version="1">MFNTHKTDQNASSTIAADEPTHAGSFPVKRAETLPSSSMPTSSSWDPDSPVPTTSKIKPSRAATMREHTGASIKSKTDTSKAKPKRANTTTSSGGGSSGKRPAPLARVPSTPTRYMEMLLHLDEIPRLYNILSSLGTWIILAGFLVVPGTFTTFKESKAFQEADGDDSNEVAHAIVHSIANIGLLWLSGSFCVAGTVLCLWLWWVWRYNYVWLVNKIFMPITLNSVAGLITTLVNVYTAQQGVWSVTAKITAIVTGSCVGVGGGLFSVYNFCLLRRVQKSHERELGLDSDQRHADETLVEKVKRKAHEPPLQPGSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5P2</accession>
    <name>A0A0D2A5P2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_00657</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240298.1">
        <property type="nucleotide sequence ID" value="XM_016375022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5P2"/>
    <dbReference type="STRING" id="91928.A0A0D2A5P2"/>
    <dbReference type="GeneID" id="27327740"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00657"/>
    <dbReference type="HOGENOM" id="CLU_024513_1_1_1"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000017">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor 30 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="203"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW20082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="245" mass="27554" checksum="75DDFB1B236593DC" modified="2015-04-29" version="1">MASVVAESTPAAPESSSKTTNPSTTPTYNFSFTPFLRSNGIAALASKVPVCPDYAATGHCPRGRRCADRHPTPSQPPQHHYGRQNDNYVCKHWLKGLCKKGDACDYLHEYNLRKMSECQFYNQNGYCQNGDECLYVHVKEGSKLPLCEDYNKGFCDKGPSCGKRHVRRRLCEFYMAGFCPDGPNCKFGVHLKSGGSAVDNSVGEVQKRDRVTDLDRREEDSRKDFGWKGGRGKGGRWRNKRERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8K2</accession>
    <name>A0A0D2A8K2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBL3-like ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241313.1">
        <property type="nucleotide sequence ID" value="XM_016376037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8K2"/>
    <dbReference type="STRING" id="91928.A0A0D2A8K2"/>
    <dbReference type="GeneID" id="27328759"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01676"/>
    <dbReference type="HOGENOM" id="CLU_055856_0_0_1"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="168"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="264" mass="28948" checksum="A18E2F57C92069CC" modified="2015-04-29" version="1">MSSANTAAEQFQQGESRTSAQDIPQQPRTQKETTTSTPVEMSSLPKTNPPTTEAEPSSSSQQDTASSEPFMTGPVRTDTHTAISQSLHPPPPLPPSAVVDSPALTRTHTTAIGPSSDSPVVPAKDIEVTGPVLVVTLLLTSGARHPFRLDNKYLIKRNVEVAENDPFNLSVYKLKELILREWREEWEAKPSSPNYIRLISMGKMLDDKASLKDYKFGTESPNVLHMTIKPQDYIEDEDAKGGKSSMAGNRETETRSPGCRCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A905</accession>
    <name>A0A0D2A905_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01852</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241488.1">
        <property type="nucleotide sequence ID" value="XM_016376212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A905"/>
    <dbReference type="STRING" id="91928.A0A0D2A905"/>
    <dbReference type="GeneID" id="27328935"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01852"/>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_1"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="265" mass="28918" checksum="DED238BA2BDE7572" modified="2015-04-29" version="1">MARQPNLYSYPTVDNLAAHLRSYILTCQKAAFQRHDAFKIAVSGGSLAATLAKALLVADSNEDPESSPQFSKWEVFFADERAVPLDSEDSNYGLLKKDLLDKIPSEQGTPTVHTINVEYLDDTQELADQYQEALMSSFASKDSVKTPIFDLILLGCGPDGHTCSLFPGHQLLRESDAWVAPIEDSPKPPPRRITLTLPVVTHAHKIAFVATGGGKKEILKKILEADDEGRSLPCGLVNEAGGEKVTWFTDHAAVEGVSFPRRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A9Y5</accession>
    <name>A0A0D2A9Y5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_02132</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241768.1">
        <property type="nucleotide sequence ID" value="XM_016376492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A9Y5"/>
    <dbReference type="STRING" id="91928.A0A0D2A9Y5"/>
    <dbReference type="GeneID" id="27329215"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02132"/>
    <dbReference type="HOGENOM" id="CLU_002794_3_1_1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="17"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="477"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="746"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW21552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1082" mass="119672" checksum="9F383184AC720B0D" modified="2015-04-29" version="1">MPAIPPSQLISLQSNPQNIRNICILAHVDHGKTSLTDSLIATNGIISPKMAGKVRYLDSRPDEQIRGITMESSAISLYFSMMRRAQEDASPKKEEYLINLIDSPGHIDFSSEVSTASRLCDAAVVLVDAVEGVCSQTVTVLRQVWIEKLRPLLVINKIDRLVTELKMSPAEAYSHLERVLEGVNAVIGGFFAGERMEEDLLWREKLDQKRAAKEQQKQDALSETATESDLDQQFEERDDEDLYFAPEKNNVIFASAIDGWAFTVRQFASIYEKKLGIKRSILEKVLWGDFYLDPKTKKVLGQKHLKGRNLKPIFVQLVLDPIWQVYNATVGVNGERGDPALLEKITKSLSIKLPPHIAKSRDPKTILQAVFASWLPLSTALLVSVIEYLPSPPSAQATRMPELIEDLVSTRYIDDKVKESMIGFSTEATAPVVAYVSKMVAIPESELPSKRRKLGAALTADEARELARRKRAEIAKAQAEAEGNSSVDGVTNGLSNAGIGEEDEDELTPEQPEDPEHLIGFARLFSGSLSVGDEVYVLPPKFNPAFPHASPEPKKVPITALYLLMGRSLEPLETVPAGVVFGIEGLEGHILKTGTLCSQLEGGVNLAGVSTLSQPIVRVALEPTNPMDLNKMIRGLRLLEKSDPCAVYEQMESGEHVILTAGELHLERCLKDLRERFARCDIQPGEPIVPYRETIVKAEEMEPPKTKNPRGTALAVTASKTVTVRLRVRPLPRSVTEFLIKHGPSLRRLYAEKQAQEDGVEAEKDEVADLGNETGNERSILSLQEFRTQLQAVFDEVKEEKEVWAKVIPRICAFGPRRVGPNLLIDATGTNTCKRFLLELGELKESGGNGTRNGHGEGSVDTTSSTHDFSDTIAYAFQLATAQGPLCREPTQGVAVFLEEVVYQPVDDTDASTESGRLTGELITSVRESIRSGFLDWSPRILLAMYSCTIQATPDVLGKVYSVLTRRRGSILSESLLEGTPYFTIEATLPVAESFGFSEEIRKRTSGLAQPMLQFIGFEMIDDVDPFWVPRSEEELEDLGVHGERENVAKKYVDGVRRRKGLLVRAARGGRDAEKQKTLKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AU19</accession>
    <name>A0A0D2AU19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230181.1">
        <property type="nucleotide sequence ID" value="XM_016386049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AU19"/>
    <dbReference type="GeneID" id="27338824"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11741"/>
    <dbReference type="HOGENOM" id="CLU_1142611_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="243" mass="27833" checksum="649C912BDFF60C41" modified="2015-04-29" version="1">MAHRGHRWVPYRTMRPERSDNNGTVFNAGQPYQTQHYMDEESHFSPGPSSQQGRLSDDQYINWHHEAILGMQEPRNDYLADRESLRYDERSPHHYELLLARERDRAQQLEIMLLRRELEDQRQQQQMRGAMSISVTSMLPVNIITTHHTDLKSNIAVLPWVAKAVAAAVTIVAAIIADVDVDVDVDITSDADTDTAVDQDVDLDHKVAMDMSMSKRAVEPGTKDGWPTQSSSTRQRDRRCQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AU57</accession>
    <name>A0A0D2AU57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230499.1">
        <property type="nucleotide sequence ID" value="XM_016385555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AU57"/>
    <dbReference type="STRING" id="91928.A0A0D2AU57"/>
    <dbReference type="GeneID" id="27338328"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11245"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="258" mass="28325" checksum="F2444ADCA4701520" modified="2015-04-29" version="1">MSATSTMNTILIVGGTSGIGESFARRFHSMGKKVIITGRRAERLQALKSELPGLETYIMDNTDIASLPAHVQTFTTQHPDIDTVWVNSGIQYTFDFKTTTSVEDDAKINREIATNVTAPMILARHFVPFLLKRPDQGTFMITSSGLAFVPMGIFPIYCPTKAFVHHFMVGLRQRLTGTHVNVIEIAPPYVETDLDAAHKQPDLPPPMPLAEYTDKTFEILNGKPAKEIKEAAVGFAAMGAEAWRGAFGGFLEHMKLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWI3</accession>
    <name>A0A0D2AWI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10347</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231264.1">
        <property type="nucleotide sequence ID" value="XM_016384662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AWI3"/>
    <dbReference type="STRING" id="91928.A0A0D2AWI3"/>
    <dbReference type="GeneID" id="27337430"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10347"/>
    <dbReference type="HOGENOM" id="CLU_115536_0_0_1"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW11048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="130" mass="14595" checksum="DE92F06DA99C4750" modified="2015-04-29" version="1">MSSPITCHVLNTLSGTPAAGLKATLTLLQKNSLYASAETFSAVTNDDGRVKEWEASSSTGRTLMEVMDWFGPGERIPWSIKFEVGPWYESQGVESFWPEVEVKFYVKKGERHYHVPVLVGPWTYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXE0</accession>
    <name>A0A0D2AXE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_10384</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231301.1">
        <property type="nucleotide sequence ID" value="XM_016384699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXE0"/>
    <dbReference type="STRING" id="91928.A0A0D2AXE0"/>
    <dbReference type="MEROPS" id="M16.003"/>
    <dbReference type="GeneID" id="27337467"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10384"/>
    <dbReference type="HOGENOM" id="CLU_009902_4_2_1"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="50"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="202"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW11085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="478" mass="53166" checksum="F743349600CDE821" modified="2015-04-29" version="1">MASQRLALNFQRSLRSRQALNAIKSPLRRYANPVTPTRTESTTLSNGLTIATEHSPWAQTSTVGVWIDAGSRAETDKTNGTAHFLEHLAFKGTNRRSQHQLELEIENMGGHLNAYTSRENTVYYAKSFNSDVPKTVDILSDILQNSKLESAAVERERDVILREQEEVDKQLEEVVFDHLHATAYMNQPLGRTILGPRENIETISRQDLVDYIGTNYTADRMVLVGAGGVPHEELVKLAEKHFSGLKSAPPTSYAAEIAAEQKRTPEFIGSEVRIRDDTIPTAHIAIAVEGVSWKDDDYFTALVTQAIVGNWDRAMGNSPYLGGKLSTFVHANNLANSFMSFSTSYSDTGLWGIYLVSENKTALDDLVHFTLREWSRLSFNVSEAETERAKAQLKASILLSLDGTTAVAEDIGRQIITTGRRMDPAEIERVIGSITEKDVMRFAQKKLWDQDVAVSAVGSIEGLLDYNRIRNDMSRNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXH1</accession>
    <name>A0A0D2AXH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_10440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231356.1">
        <property type="nucleotide sequence ID" value="XM_016384754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXH1"/>
    <dbReference type="GeneID" id="27337523"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10440"/>
    <dbReference type="HOGENOM" id="CLU_1741824_0_0_1"/>
    <dbReference type="OrthoDB" id="3923202at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="145" mass="15218" checksum="C48363BA53BC9908" modified="2015-04-29" version="1">MAEVCPIVGTTNTVLPPKHPEFDLSAPGLVCPVTKATTDHHHNLSKHPGIFNNSDDLSNASSCPALSKIVSRPEQQAMDEAICPVVGTVSSVLPPDHPSTANAKEGDVCPVTNATLGHHKGKVHEHPSLQAVSKEAVCPVVHKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXU5</accession>
    <name>A0A0D2AXU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_10793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231709.1">
        <property type="nucleotide sequence ID" value="XM_016385107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXU5"/>
    <dbReference type="STRING" id="91928.A0A0D2AXU5"/>
    <dbReference type="GeneID" id="27337876"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10793"/>
    <dbReference type="HOGENOM" id="CLU_488311_0_0_1"/>
    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="37"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="612" mass="65693" checksum="797EF608E527A82D" modified="2015-04-29" version="1">MASTTQPGYVILHVRDLHSDGPFPQRRVILTSPDWFVKIGRGNMTSDEGLIPSLSNTTFDSRVMSRNHAIFSANPETKEIFVTDVGSMHGTHLAGRRLKTEEPAKLSPQDIITLGADVSRGPSFYKPVKVSVDWTWYENDDESLNDNPASTQPTRNSFSAEYSDEDAYGSDVDPRELNNFQEHTGLEQEVVVAENALGEKRADTVDEDEEEDAAVNAVEDSFCFPRVEVTASLSRTFSVPDSDSSDVNSYVSSSEDSNIDSPTSSPVNAAQVVEGKEVAPQYIDMGADIPAQTAQADYEPTATPGFSKTDPADVIMWSSGCLDAIRDGRENDANSGCPLPTEADPLGPRPIRSALEELPKTTRLDTLALPQDRVHAHRAPSPSDAAMAKSSTSEMPRAPPFVQSSATTHETFPADYPETRSISAWAGHNSVLYDFHTGPPTGCVKETPPWHREWAGSSPCTALTLPPLDPNRVLAVAEPVPASAGNHVLKPEQSHKRKADHLSSDNLSVHTADEFLHLWETAKPDPDLVNDAGAEAREESPSSSPLADIPVQSTEIDDQPARKKVKTGVVSVTEPRGNGTSDAVKLVVAAIAGVAIGAVGTVIGLAALPPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZM1</accession>
    <name>A0A0D2AZM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_09173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232116.1">
        <property type="nucleotide sequence ID" value="XM_016383493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZM1"/>
    <dbReference type="GeneID" id="27336256"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09173"/>
    <dbReference type="HOGENOM" id="CLU_021993_0_0_1"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="71"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="490" mass="53080" checksum="1E0E6370A19F60EA" modified="2015-04-29" version="1">MQTINSGPGGNSSTAIIELPTTSHLRIDTEKAATTATPPAPTIPNAPFSSPQTDNKPQLQKWNSPRINVWRCAGTFWSFMILGASDAAYGALIPYLEDWYNVNYTIISLVFLSPLVGYILSALLNNHIHMVYGQRGVACIMSMSHLLGFVAICLHPPYPVLVVIYILLGFGNGLGDSGWNAWIGDMADANEVLGFLHGFYGLGAALSPLIATSVVTKAGWKWYEFYYLMVGGSAIEVIILVGTFWKADAHAFRAQRSMAGEAQPTISADATSQSLHEQSTWKKLNPFGKREEGKSRTLEAVKNKATILASIFLLAYVGAEVSIGGWIVSFMLRVRKGSPFASGMTSTGFWLGITVGRFVLGFVTGRLFKSEKWAVTTYVTCSVVLQLLFWLIPNFYVSAVMIGFIGFFLGPMFPAAVVVLTKLLPKRLHVAAVGFACAFGASGGTWMPFAVGAIANKAGVKVLQPIILAALVLCLVVWLLIPRLPKQRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZW7</accession>
    <name>A0A0D2AZW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232186.1">
        <property type="nucleotide sequence ID" value="XM_016383563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZW7"/>
    <dbReference type="STRING" id="91928.A0A0D2AZW7"/>
    <dbReference type="GeneID" id="27336327"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09244"/>
    <dbReference type="HOGENOM" id="CLU_010194_12_1_1"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="32408" checksum="E3A53113153C6497" modified="2015-04-29" version="1">MAADIGKIEAGKLFNVNGLVAVITGGGSGLGRMMARALAANGAAKVFIIGRREASLKETADSVPGGIIIPLVGDVMSKPSLQQCVDKVKAEVDAIDVLVANSGISGPSVKTVDSNRQPIGIDQVIQNMWAPEHEDVNSTYGVNVTGVHFTIAAFLPLLDAANKKRPQPPTEENFKPRPQIITTSSIGGYGRYPLGNLSYGPSKAAVRHMSKQLSTVLVSYDIRVNVIAPGLYLSEMTEDMYKSLGSFESHNVEGTFPKEMIPATRSGDEQDMAGVILWLCSRAGAYINGCTVVTDGGRLGILPSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0C0</accession>
    <name>A0A0D2B0C0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232619.1">
        <property type="nucleotide sequence ID" value="XM_016383996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0C0"/>
    <dbReference type="STRING" id="91928.A0A0D2B0C0"/>
    <dbReference type="GeneID" id="27336763"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09680"/>
    <dbReference type="HOGENOM" id="CLU_476510_0_0_1"/>
    <dbReference type="OrthoDB" id="3800389at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="62748" checksum="35AD33F33E8C3928" modified="2015-04-29" version="1">MDGGTVSAAAVSSATNAVLRVSQIIYELIAVGEQARDLLAATKHVAKSLDTTRHLRRCKSMHLEATEKEWIDSIMVDASKTLNNVATLVESVRVDMQTKHGKIGLVNRGLFVFRDSPKIPTQLTQLSIASQSLNTALTILSQREGQPSPSMLHHPKLDHRRSTASLISSPKQPPNYEESEFLNRRRRSSNTSSLLSPVQSPNEEPLSTPGGASVILEDEDTVLRSNQTAERQAQFRPHPAPPQIDNEKIVISTEHQGNPLNRGFNATPYYSSWENDSSHPDTTRHSNTVWSGHQGHSQADGYVYKAYNPWLEQLGSRSRRPSHNADQNSETFNSHSRAWPQACDEPFFLPQHDRTSSYEKINSGARSSLLDLSPGNNIPHLPGQSGLNISFPLTPPGNNPGGPVLQKVCSRTSVSMSSPLSQVPESEPCSATSAASSSCSPTAQPQLLTPYPLPGQGIRMPTQYDERHSHHESHSPYSIHNSPGTASTTVINKDFMPLSTYESESGSRRSARSSLDYFSQGTSGETGGLDMTKGLARDGSISQPSQEQRSSVHFTRTRSRKYAWLQHHAGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0J4</accession>
    <name>A0A0D2B0J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232451.1">
        <property type="nucleotide sequence ID" value="XM_016383828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0J4"/>
    <dbReference type="STRING" id="91928.A0A0D2B0J4"/>
    <dbReference type="GeneID" id="27336594"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09511"/>
    <dbReference type="HOGENOM" id="CLU_010194_13_3_1"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF31">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="304" mass="32986" checksum="D29D228AC6249AF9" modified="2015-04-29" version="1">MAFSAYTNKPVDTSVRVDITTLGDKSVVITGGASGFGENHARAFAAAGAFVTIGDINEDKGRKLVAELGRNAQFIKVDANSWEDQLHMFKQGVANSPAKSIDIVVINAGIAGPDEIFAMEDPAAEPTKPTLAMLNLNLIASIYTFKLAQHYLRLHPVGPARDRCIIIKGSIAAYLDQPGSFLYQTSKFGLRGLVSCARRTSWAEGIRVNSIGPWYTKTSLMKPHIVDILISKGVEFADIADCTTAVLRVACDKTIHGSRSLAVLPRSLAPNGYIDTELDDFEKEPWKPLQRVMLEASIRAVPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B186</accession>
    <name>A0A0D2B186_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_09956</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232894.1">
        <property type="nucleotide sequence ID" value="XM_016384271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B186"/>
    <dbReference type="STRING" id="91928.A0A0D2B186"/>
    <dbReference type="GeneID" id="27337039"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09956"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW12678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="548" mass="63315" checksum="3B29B10F8B35800B" modified="2015-04-29" version="1">MSHFETSRFFLAAFAAGVSVHLAVFRVGEWDLWAVHILRFFGALYCMALLGLQYYYVENTFLESFRIASMLSTFFGVGLFGSMLLYRGFFHRLCRFPGPFLARFSNFYPTYLSCKNIQLCDEVRALHRQYGDIVRLGPTELSINNVDAVQKMHSSQSRCVKGPWYNVLNPFQSLQMVRNKAEHSQRRRVWDRGFSVKALQDYESRVVRYTDQLMDQLKKSEGKPIDMATWFNFYSFDVMGDLAWGKSFHMLRDGIKHYFMLCLHADMMNIGLFSHLLWLFPIFKATPILNRTHKRFRKWVRDQVAERKRTTPDRPDVFSWILEDYEKNQTPTFQDELNLEGDASLIAIAGSDTTAASLTCMFFELAMHPEYASMIQKELEEALTSSAEPDAVALRKLSFLNAVIDETLRLHPPVPSGVQRMTPPEGMTIADVYIPGDTIVQIPSYTLSRDERYFEQPEEFLPERWTTRPELVKDERAFVPFSTGRYSCVGKQLGLVEIRQVAYEILRRYNVALAPGQTPSAFLKGILDTFTLQLPSLNLVFSPRQKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B296</accession>
    <name>A0A0D2B296_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232956.1">
        <property type="nucleotide sequence ID" value="XM_016382253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B296"/>
    <dbReference type="GeneID" id="27335009"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07926"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="503" mass="54798" checksum="3CCA055C32AEF1A7" modified="2015-04-29" version="1">MVGGGRFLELMRSFEITGLAKQLMGKRFAVFRRRKSPLEVQSSQPESTTDVGQVVGSIVAAYINEPFGRKVSLTVTAVISIVGVIIELTSAIGSSRYSQFVVGKTIASIAMGMALNIVPMYLSETSTAAARGFSVNMYQNLILVGAITASGVVYGTSQLQTAACYLIPIGLQLIAPTFLILLTPLLPESPRWLATKGRTGPAIKAADRLFKTKTNNFEAADYVHKIHLSIEQDRANQEATGWMDLARGPNLRRLLIAVGIQCIQQAQGVTYILNYITFYLGYAGITNVFPYIISAFCTNYLGVLTGYYLPDRFGRRVLVICTSLVCAVALVIMSGIMAGTSGGASGTVIVVLLFIWMLSLGAQSPLIWIITAESAPTRNREKVIATAVFFGFGTALLTASVSPFIADPGYGNLGGKIGFLWAGFSFLSIVWVYFVLPEMKALSLEQLDFLFNNHVPTRKFSKYVFTDLVLAVHEKDVHETTIGNEDSQNQNKNALEETVELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2P9</accession>
    <name>A0A0D2B2P9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233106.1">
        <property type="nucleotide sequence ID" value="XM_016382403.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2B2P9"/>
    <dbReference type="GeneID" id="27335160"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08077"/>
    <dbReference type="HOGENOM" id="CLU_001428_1_1_1"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24965">
        <property type="entry name" value="TRS130_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="920"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="5">
        <location>
            <begin position="1254"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="519"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1406" mass="157120" checksum="11ED5E64FB5E655E" modified="2015-04-29" version="1">MDGSDSPASSKVIIQCIDPHNLYDSLEPRLSQRSPLRNLHWKSPTRPLRSIPALNITLSREDQSAGTASNVRRHQIPGLRETPYVKLYLLRCDDRETYKEKARKEVRQWVKSQISAADGKSNKNQEDHDAFEWLIVHVVLANTPAASQPRSSKHISLETTESTDSVNSKSKWSGKSSSTIFDRLRADFNSGSKSPINRVAQVRLLNSHDKGTPLSPADLEEQWQELIDSIKACILRSFDARVAQYESDIREKDGQRSLPGWNFCTFFILKEGLAKGFESVGLLEDALAVYDELSLGLDNLVKEQFRTGDNEDSGALLTVSKESKALLRAALEVEDSSSSNDISKQMLDLQDILTVDREQFPFDAERKNYQSLILTNDVSALDLRIYLFARQMELLLRQARAEASDNTPGSKSSVNLNILADLAERANEFINLAARSLRMELYGAWGGHEGLSADELFTQRAVTGNIVSTFEWRAVMQIMSKVLPSLELDVEYGTGWLSLDSVELFRIMDKSSTHIQEARNRSKRMSLAVDSRSPSRERSQGPHHKRISVIPEEATTRQVVFSRPGAERLAVWISRLVIMARRAVSNLEAVQPWLVEMKRAALHYDLNINKNMTNGMARRSSIFKAEDQKQATDKSASMAGLDSNTLTAAASSKSTFLELFAMLSVLAYRVVADTSSHSTAQQVLIDLVELEYAQGNYGRTARYLHSILGPLPKTTYKPSDGHLLRIYADCLRHLDKPTEYARCLIAYLHCGLYGGSTGKPSATQAASYVDQLFQTLPKIDVTTLPMSTLFMIPRVSKAITHVASQDGFALRISLQPLSPMTVPLISEVKLRLSSQAIEPRFISLTLSESAAIEEVGTELFLSTTVMAQGWYMPSELEVNIGKLRLLHHFRSTQHDEGFPVEDSPLEQAVVVPVLVYPGEQSMNVDIVHAPVVHLAETRKLLVNLMPGHNSVSQCRLRLKTATAGLRLNIHEAKAHGKGQTLQSLRTAREGDALMMFIDDLKPYSKSSVEIPYSLETQTEPSVVIRVEANYQTNKGTFELYDTASVNVILPVTVNVQDIFRDTCMYSRFTISPSTLVPLRLVRCELERNQAYHSVNSGDFDQPEMVFPKQPASWTTRLVPSTPTAIGVTQKLTLCVDFQAVDELILSSLEDNFISELSKTRHHGTARLLAGHLRNRVRTSWTEQDLEVAALTEEVEIWSMEDMDWQSVLCALDSQTRREVELWLQDWHAQTKPIKLLVDKAQTRQLKLYVDIAPHPLLITACLDIHCAKPESPTAIVGQPMLADLVMRLSNAREDEVTAQFEVSNSDSWLVGGRRKGHMQLSSKASRTRVVLVPQHIGHALLPTITVKCRKQKKGSGGEEVWTEVVSDVHNPMHGRCIEIIPSIRSTTVEVFGDTPTDGSGRLLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4H1</accession>
    <name>A0A0D2B4H1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spo7-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234059.1">
        <property type="nucleotide sequence ID" value="XM_016380957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4H1"/>
    <dbReference type="STRING" id="91928.A0A0D2B4H1"/>
    <dbReference type="GeneID" id="27333706"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06623"/>
    <dbReference type="HOGENOM" id="CLU_032659_1_0_1"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="58780" checksum="2A277C721F106EF3" modified="2015-04-29" version="1">MSSEKTLNQLVKGAPTADVKPPPTHPLPHLDSTADPTLATLPSSPPQIYLNLLILETSLRAQYLHLVSRRRLNTFFLLLLALWNIGFTYALFLRPREDGTGLGGSVYWMVETTQKLALITGVVTVLLVYATGQWDRGIRWPRKWLGTTNRGLRGFNLRVVIIRDRFWREMLGHMSFLMPYGLWRGESGGSGDWHLVEHEDGTTAEEDLAPGGDGIMLLLLPKSFSPEFRENWESYRTEYWEKENERRVHLRKKLNLQRRVRAKDEGGWKWWTGAWRLASAPHRHHARNHHDLEKHPHAGHPTARHGSVTASIGGGTGTGPGRRRPGNALDSDSYSGAASRGTRSRQSSRSSTPHLDFSESTVGAGGGPLLSERVRRGSSVSSTASARRKQQQQQHRSGSTTTGTGAGAGGTERRDSAGLSPLTSHSALAMATTAAASTAPVEHDEREERRRRRREREAARERKAARERGEEEQQEQHDANNSAASSPPTTPRIGTFNHPGTSTSTSTSTSTSVINNSSTSKVKSEHGLGLVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4W5</accession>
    <name>A0A0D2B4W5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NAD+ kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234164.1">
        <property type="nucleotide sequence ID" value="XM_016381062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4W5"/>
    <dbReference type="STRING" id="91928.A0A0D2B4W5"/>
    <dbReference type="GeneID" id="27333812"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06729"/>
    <dbReference type="HOGENOM" id="CLU_008831_7_1_1"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="601"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="71706" checksum="3F50C8324A83B418" modified="2015-04-29" version="1">MTNATVVDAAPCSTLSSPTTSEATSISNFSPPTPALDNPDQALHHGMASPDPKVSVGDSILHLYAHHLGSLHADDETHAVHSITGRDTAADDETVLNTVLNLANNRPSHFVRPSYLAHHPSAPVPKPLSLPKPLITHRKNTKSIDIPRQTIMKALASRGPATGPTTAPLGGSPFTNINNGRDAEEQSLAAAGLSPCTTATLSAMQPSAFSGCSPTSTSFLRSPCFFHQRFDGIVDVQKVLDEIAEDDYSHSRLMQTAIGVREVSKQLQRKPLKRAVRNVMIVTKARDNSLVYLTRDLAEWLLSTPRYGSDVGVNVYVDAKLQHSKRFDAPGLLKKEPRFEQMLNYWTPDLCWSSPEMFDLVLTLGGDGTVLFTSWLFQRVVPPVLSFSLGSLGFLTNFEFDKYREHLDRVMGDSGMRVNLRMRFTCTVWRADRSPGAEKGAVEEGEQFEVLNELVIDRGPSAYVSNLELYGDDELLTIVQADGCIFSTPTGSTAYSLSAGGSLIHPSIPAILLTPICPHTLSFRPMVLSDTLLLRIAVPNKSRSSAYCSFDGKGRVELKRGDYVTLEASQYPFPTVMTGTNEWVESVQRALRWNVRGAVQKGWEEGDDEENDQVEEKWDIDMDPSAAGGTDSGIGPSEDGDHVASPLPRQMSLLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4Z1</accession>
    <name>A0A0D2B4Z1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7066 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233981.1">
        <property type="nucleotide sequence ID" value="XM_016383278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4Z1"/>
    <dbReference type="GeneID" id="27336039"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08956"/>
    <dbReference type="HOGENOM" id="CLU_383108_0_0_1"/>
    <dbReference type="OrthoDB" id="4145020at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055494">
        <property type="entry name" value="DUF7066"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23217">
        <property type="entry name" value="DUF7066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238901" description="DUF7066 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7066" evidence="3">
        <location>
            <begin position="236"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="722" mass="79359" checksum="622BB6681E1A59FB" modified="2015-04-29" version="1">MKINWNSIDALSQLLFAVYAALGEEEFEGRYDAIARFYAPEGAVEAIAKDIKKFFAKEFNKKTAVQKAKNDKHPPTGRRNQRSSKQPGQSPPFSFDEEDPSISTGREDEAHPDHSPSTSAKRPLAINLLPNREEPGNWGVLSESPAPQYIPNTSHSVQQVALESRPEPPRVNAVSYDGGTSSQAPARHSRISMQTPDGTNKRPSLVVESATLKGDQSASLPAPNSTGPFSEVELFTYTTKGGDCRCGLCLTQLPTELELYLHERQSHEHLLNLTNPDKVRKAREHLAEVRGFAFAPSQSTIIPRQQISINGLLNPVASAAARRLETLDVTNNQASSQAQVHHQNSAFQTSHTRNDFLDTIEVRRRPASTPSAPTVADGAVDAETPDLRRRRRRRPPSPPSSPQRMQPADKGKQRTDRLSPPNTREDTELRAANPHRGPHASHVVDADSSPPVRHHSFPPPPPPPPPGRRIPLPNTPATTYTPVGAMSPMSSAQITLSPGSSVALLQTDMSSPNPQFQTPAPGVRKLEPITPDTWPPSVVTHQDPGRPGYTDKSVNSSIGTPRFIRPELAQILRSTVEVVMQEAGDVQLDTVISAVLKGISTSDPTCGRHMIPLAGPSRGYRENPPWNEGHVPLENTRRYNSEYRSTENPAAHDAEPRGYERLDSLTVSGGRGHGRSDGRFNGEGGGKLNGRAYDDREDSQRTRKRARRREDEDIQEYIMIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5T7</accession>
    <name>A0A0D2B5T7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234221.1">
        <property type="nucleotide sequence ID" value="XM_016381119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5T7"/>
    <dbReference type="STRING" id="91928.A0A0D2B5T7"/>
    <dbReference type="GeneID" id="27333869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06786"/>
    <dbReference type="HOGENOM" id="CLU_046738_1_1_1"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="41380" checksum="4CE5EF2FE75C9756" modified="2015-04-29" version="1">MTNVFGVQIFFIIFRECLEAVIIVSVLLSFLKQCLGQPHQDPVIYKRLKRQVWAGSLGGILIALIIGGAFIGVFYGLGHNLWAESEDLWEGIFYLIASLIITVMGLAILRINKTKEKWRVKIAQALVAKKHHKDAASRLGEWSRRYAMFILPFITTLREGLEAVVFVGGVSLGLPATAFPIPVITGILAGLLVGFLIYRGGNYMTIQYFLIASTCVLYLIAAGMFSKSIWSLQFYKFAQQVGGDVAESGNGPGSYNIKQTVWHVNCCSPEIDHGWDIFNAILGWQNTATYGSVISYNIYWLFIIVCICFMLYEERTGYLPGQKAFLNFLSKVPGFRSYAGRKLTASKQDAAAIIKQVQADNFTHGVQGPLAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5Y4</accession>
    <name>A0A0D2B5Y4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234291.1">
        <property type="nucleotide sequence ID" value="XM_016381189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5Y4"/>
    <dbReference type="STRING" id="91928.A0A0D2B5Y4"/>
    <dbReference type="GeneID" id="27333939"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06856"/>
    <dbReference type="HOGENOM" id="CLU_011172_0_0_1"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="714"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="729"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="791" mass="88406" checksum="F50F4B92A52F394F" modified="2015-04-29" version="1">MAIIDYNQRASSFSMVALEDRFEVIKEIGDGSFGSVHLARVRANGANVARRNTMVAIKTMKKTFESFSPCLELREVIFLRTLPTHAHLVPALDIFLDPYSKKLHICMEYMDGNLYQLMKARDHKCLDARSVKSILYQILSGLEHIHCHHFFHRDIKPENILVSSSAPHDSQSSFSRYSSLVTPPSTPPTYSIKIADFGLARETHSRSPYTTYVSTRWYRAPEVLLRAGEYSAPVDIWAIGAMAVEIATLKPLFPGGNEVDQVWRVCEIMGSPGNWYTKSGTRVGGGEWREGTKLAQKLGFSFPKMAPHAMETILQPPQWPLAFSNFVTWCLMWDPKNRPTSRQAMEHDFFTDAVDPLRPKSSSRLLGRKHSDLSFRSKDTAETPTITSKPSWFRRSLIARESAPAVPQHNPESKVVQQQEPESVVSRLRPQANKRATWTNGTNPIGAAPMPILPSIRPISPLPNAVTAQASSAFTSQTESKPSSKATEEKSKKIGRQLSLNSHGNHYADIHRQEAERALNANSGLVSPPSGQKESFFSHLRKRARRFSGRHGLASPSGDDVEANAANVPWSNRSSLMVDSVIPETNQDFSDLDKILQNVRYSLDREEAEAASRSHSNSKNNQGSLKRTHSVPRSEGRRSSENPTPNATNLTTRARRPPVQANQYETPEEADELLDEALRSANRAVRRLDQNTNTKEQPQRQVLAQKDYHRQSLPHISSNPTLQGAYLTPSPSAKRNGVQFNATPAQPLNITKKRNDNEHVNSLWPTPPYEENEWGAAAANSIFAAGSSIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6V6</accession>
    <name>A0A0D2B6V6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endonuclease</fullName>
            <ecNumber evidence="17">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_07193</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="17"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234626.1">
        <property type="nucleotide sequence ID" value="XM_016381524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6V6"/>
    <dbReference type="STRING" id="91928.A0A0D2B6V6"/>
    <dbReference type="GeneID" id="27334276"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07193"/>
    <dbReference type="HOGENOM" id="CLU_055174_0_2_1"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000004">
        <property type="entry name" value="Nuclease 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="19">
        <location>
            <begin position="101"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="18">
        <location>
            <begin position="102"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW14410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="354" mass="38563" checksum="9CD4D6471D98FCB9" modified="2015-04-29" version="1">MSKTTLAIVAATSAAAGASLSALIFSRPSKSPPTPLPPSPAKDASLAPVVPVPAPPAPVAVPNPIPVIAPTQSALPAVVSPVDPAGILRYGFPGPIADTLSTPSHLSSFNRFTRNPHWVAEHFTAQSLLLNNGSRRNSVFYEDLSVPPMFRAKLTDYARSGYDRGHQVPAADAKWSQAAMDSTFVLSNMCPQVGEGFNRDYWAHFEEFCRNLTKRYPSVRVVTGPLYLPKKDEKDGKWKVSYEMIGNPPNVAVPTHFYKVIFGEEAANDPVGRVALGAFVLPNAVIPNTKSLKDFEVPLEAVERASGLMFAEKLPSDRRKQLCREVTCEIIVREFDKARQQTRPPLPQPGGARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7J7</accession>
    <name>A0A0D2B7J7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234871.1">
        <property type="nucleotide sequence ID" value="XM_016381769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7J7"/>
    <dbReference type="STRING" id="91928.A0A0D2B7J7"/>
    <dbReference type="GeneID" id="27334522"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07439"/>
    <dbReference type="HOGENOM" id="CLU_1482011_0_0_1"/>
    <dbReference type="OrthoDB" id="4121246at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="182" mass="20682" checksum="9A59CFF5084AE6FC" modified="2015-04-29" version="1">MTGWLWLGDRRLLSALYSRPFQFTQSPIQYPTSYEDPNTGVYHAQLTGDQKGNLQHLFNREDEPMVLIGSYVITSCGLNLQHRCHHVAFLDPPPSKATGEQAVARVHRVGQAEIVDAITFSTNKTFNDRQFLNNIRKAMPGLLASLNKRLFGRNITSAAFEDEEFVPDVGEWVKWQGVIIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B964</accession>
    <name>A0A0D2B964_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_05489</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235659.1">
        <property type="nucleotide sequence ID" value="XM_016379832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B964"/>
    <dbReference type="STRING" id="91928.A0A0D2B964"/>
    <dbReference type="GeneID" id="27332572"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05489"/>
    <dbReference type="HOGENOM" id="CLU_063339_1_0_1"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="72"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW15443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="214" mass="22937" checksum="CE57018469D3CDBC" modified="2015-04-29" version="1">MTPSEDTHTSHGASRSEPHASSTTSQLSSAQTLSELKAKIKAGLKQYPDFPKKGILFEDIFPLFSSHSLHQDLIRAYELQIFESFGPANKPDVIVGLDARGFLFGPTLALKFGAAFVPVRKAGKLPGRLETATYEKEYGTDTFAIQADAIQPGQKVLIVDDLIATGGSASAAGTLVNKCGGTLIGYIFIIELTFLGGRNKLNAPVYTLTESQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9F8</accession>
    <name>A0A0D2B9F8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05611</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235779.1">
        <property type="nucleotide sequence ID" value="XM_016379952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9F8"/>
    <dbReference type="STRING" id="91928.A0A0D2B9F8"/>
    <dbReference type="GeneID" id="27332694"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05611"/>
    <dbReference type="HOGENOM" id="CLU_024775_1_0_1"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="43"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW15563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="435" mass="46818" checksum="2AD1D86829F4399F" modified="2015-04-29" version="1">MEQTISKSRSVLLLLARRLPRDSSAVRRTFSTSRSNDADFTHAVIGGGVVGLAIARQLAQRTGTSTILIERHGSVGTETSSRNSEVIHAGIYYGPSSLKTRLCIRGKNLLYDLCETKSIPYRRTKKWIIAQDERQMQHLTDLHAFTKSIDVPTSFLSRREIQDREPDVRADAGVLESPTTGIVDSHALMSYLEGDLDSLGGDQVLHTVVTGVEAVRSGGGPSADDPGNGITSYEIRTRSRDGAGGEDTITAECVVNAAGLGAIAVNNMLLPPERHRTAYFAKGTYFSYSASRPRVKTLLYPAPVPGLGGLGTHLTLDMGGRARFGPDVEWVDDPTDLTPNPARLADAVKVIQTYLPSVDVGAIDLDYCGIRPKLSPGSSGTYGKDGKGFEDFIICEEHGFPGFVNLLGIESPGLTSALAIAERVEDILYGEKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAB3</accession>
    <name>A0A0D2BAB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_05541</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235711.1">
        <property type="nucleotide sequence ID" value="XM_016379884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAB3"/>
    <dbReference type="STRING" id="91928.A0A0D2BAB3"/>
    <dbReference type="GeneID" id="27332624"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05541"/>
    <dbReference type="HOGENOM" id="CLU_010365_3_1_1"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF24">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="308"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW15495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="607" mass="67736" checksum="7532511B51F10AF2" modified="2015-04-29" version="1">MASTTASAAYVSAGNGTQGSSQYQNAGAQEHLAHLNKILAWNYLWALLGVAGVAFVYATFRRIDTHVRHLASMNRPAALRYFSKPSSTLSLIKSHLLYAPLLHHRRAGELKVSKRISFGTVPTRLQAVFIFLLLATNVFACVWNIPWPAPELQVLPVLRDRFGSLSVVNLIPIVVLSTVKNPLIWLLDISYDTFNLLHRWLGRISILQGIAHVICYLIAKVKTAGWAGVGKSVQAKFIYSGLIAAIAFTVILLQSPKVLRGLSYEFFLHFHIVLVILMCVFLWIHLDVKTLPQRHQLLGFIILWAVFRAWRFATLLYRSFGSSVCKAKVEAMPGGAVKLHITSPRPWQYRPGQSLFLTIPSVGLWTAHPFSVAWSGSEETISRSDSTRTFNEKAPIVQRKEVEVDARGDRTMSLVIKKHRGLTRKLWDRAGKAEGHLTVNAYIEGPYGHEQSLSSYGTVMLFAGGVGITHQLPYVRELVEGYSHGTVAAQRVTLVWVIRTADCLDWIRPWMHEVLNMEGRREVLKILVYVTQEGLTQSVRSPSETVRMSRGRPDVLSLMAQEVEQKMGCVGVSVCAGGGLADEVRRSSRVLLGQGANLDFMEETFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAF5</accession>
    <name>A0A0D2BAF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235756.1">
        <property type="nucleotide sequence ID" value="XM_016379929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAF5"/>
    <dbReference type="GeneID" id="27332671"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05588"/>
    <dbReference type="HOGENOM" id="CLU_1315433_0_0_1"/>
    <dbReference type="OrthoDB" id="4502894at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="209" mass="23358" checksum="21D95B061E44494F" modified="2015-04-29" version="1">MAQNHRGRSLLHRPLSDPGTFEGTIIHFGVDIYPRNIHWVISPRSDIDSMAHIRSFRGLPSSLIALGVVRYLLLSQALWYFIGSAVVLGAALGLFLHFAMRAVVLMFKLDKKPKVDPAPPTGHDAISYRKAREEKKRKQLEEQQRLAVQAKLIASQPLLQDAVREARKMPLSSTPIGPLSPNISVSNRHGLLQQTILEHSDEDDDSSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAL4</accession>
    <name>A0A0D2BAL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235836.1">
        <property type="nucleotide sequence ID" value="XM_016380009.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BAL4"/>
    <dbReference type="GeneID" id="27332751"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05668"/>
    <dbReference type="HOGENOM" id="CLU_001011_1_0_1"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26523">
        <property type="entry name" value="Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="4">
        <location>
            <begin position="293"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="3">
        <location>
            <begin position="633"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="5">
        <location>
            <begin position="861"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1538" mass="170701" checksum="4BB1E5B923991237" modified="2015-04-29" version="1">MDVVSRALEAPIPLSIAILSDLGKGALRQALRQADQVPQLQTLWKGLILTVRDPQVLDKHITAACNALCVFINASAASPCAELRCFTISREVWLDAFQCAHKAFDDGMTKPAFQVLETLCDMLKEMSDTEVDSIMTIAVPPLVEIVLLCSPRSGLKKACLMLAGFVRKTQVHDYLERFVEKTTTSYALAWKERLVEHHITVMDLSEIGNGSMPSLLLALIFASIDVNTRSTAIKTCSALCSRGPARPGRPSLHDLVESVIGLYLERNHEALGDFAQNILPVVLDDKHRFAAFARLHARDSCESEARLALFLSTLRAGVSKSLLTEGETLSIFNSAFPEDRHSTEQDPYRWFSHIFKLSSSEIQILTYGLLTASAAANSIVPEGALNCISLGLRYLHDDADAHERGEIMSVTKRLLRRIQAGCSALLKQKQNGSVSEADVVVASYRRFTSSYYHFLRAELSSGVSYPRHILALQSLQCLLDSRLEIGTFSSDSELMTYLCNLILDPFEDVRQASTALLHCLASETPEVLSLAINPGLLHGVESLVVQTGRSDHADGMGRLWAIRSHLNRILQSQQNSAETALLRCITQLEAQLSIEGSLQPGSIYPLHGYLLGLSFQLRGFEANDKQATKFDAARILRVCSQVWDQVRSQLCVDSPERTSDLADDDGTQGPKDMLAYSWRALRDSSLVLQSLLLASGPDKDLYSAIGSLCMDQLMSLRHRGAFSTVANTFLLCCETVRTSTEAGVRGLLQEWYRIALAQIDEQADRLTRRSAGLPAMITALLSPSDMVVFSSAIADLTTIAKQTAEKTASDIGEPRLPQVHALNILKDIMTTSRFAAVVVHFLSSIIELAAFCLTSKIWAIRNCGLMLLRACINRIDSSNVFENADTIYSTELVFRETSSSIAVRMLQSAHQIPHAAANDTIDPTELVFAALDLLGHAKITASKSAEIDVVIARELSNPAWAVRDHAAFLMSHRLSPLGTGHAVHKLFEATATLSCENGIHGRLLCCRYIMEAGTNSLNINELGILLELLAKDFAPSSTATAWSPYVNAAWLDILNDASVLIWNRKWPSRMLCVHHFPDEVQALQSRISVHSPFLTQRLLLYKVFCYMFSDITPSQIETRKGLVCQFADDPEALRVFLETVHTKISGRPTPTLINLLVSLISENYSALMGQPEVLERAFACLESCLASDLKPDLSLLMPLLDNIKLQELATSRGLWTTALKLEAHMLRCFKSEHMADSASMKRTQLWLDAVGYASKDYLEFPSRLSAAVALSTYIGHVKSTMENSYEKRLWPRLLVLLYDLLNDDDEEVRAEAVTAANMLSLQHMPIISNLGLCPLAIREALIEELCQESVRSHYPIEAILNRYLRIGRDVQGDLEDDHSLHLFEHSVSSRLTEIVRSKNDLFAEERQNLYVDDVRELDIWSYVLCQYSFHLLPSRRLQLVLRWACEGLDQIANMMGRVGPSSTNLTLSHPLGVTYDHDFLVVFVQVVNLAGALLHCRLNAIPGNELHEKLEHIHQSCRDTYGNPVATEAVNRALENSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCY3</accession>
    <name>A0A0D2BCY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PV08_04018</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 16"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237044.1">
        <property type="nucleotide sequence ID" value="XM_016378367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCY3"/>
    <dbReference type="STRING" id="91928.A0A0D2BCY3"/>
    <dbReference type="GeneID" id="27331101"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04018"/>
    <dbReference type="HOGENOM" id="CLU_045153_0_0_1"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="229"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KIW16828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="320" mass="36181" checksum="F12532ADD60D5302" modified="2015-04-29" version="1">MADIGDASGYDDSNRAFLQAFLARSVLTLTTAQPILAALLTYRDGREVQPQDVTVEDLNSYIADSNQRLSPLDLEIRSTFHQKTRERIYALVNTTSDPLTQLATTYSADEIVYLKKLLDAMFDGPNNRGKKEAMCLSGIEALQVGRSQGNRRATQDGDGGTTQTNTSAFVLKDTEAMLAKLVDEGWLEKSRSGFYGLSARALMELKGWLVDTYNDEDEDGERKEKIKFCHACKEIITVGQRCPRRECRCRLHDICTQNFFRMQRSQTCPICKTDWDGQHYVGEKAITMSESYQMSRRKSGHRRPAEAERQRDADEDDEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCZ9</accession>
    <name>A0A0D2BCZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236696.1">
        <property type="nucleotide sequence ID" value="XM_016380869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCZ9"/>
    <dbReference type="STRING" id="91928.A0A0D2BCZ9"/>
    <dbReference type="GeneID" id="27333617"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06534"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="483" mass="50612" checksum="BA1B7E8E53061EEC" modified="2015-04-29" version="1">MSFQTNLFINNEYVPSSSGETLTIYSPNDDTVVTDKVQVASEADVDRAVAAAKKAFPSWSSTPGVQRAKLMLKFADLLEANAEKLGKLESICMGQPVTLAKGFVAGACATWRYYAGLAGKIAGESYPPEGDGSYKIVAYEPLGVCAGISAWNGTHVLAAWKMAPALAAGNTFLFKSSEKSPLGAAAYGELIKEAGFPPGVINIVTGAAPVGAVMASHMDIAKIAFTGSAAGGRAVQIAAAKSNMKHVSLELGGKSPALIFDDANLDNAVAHNATGFLRNSGQVCFASSRVLVQEGIAPKFIEAVKKAFDDAAKKMGNPALADTAFGPLADKKQFERVMGFLVDGKKDGIEVLTGGGRLGDKGTFVQPTVLLNPDVKSRVFTDEIFGPVIAVRTFKTEEEAIALANDTTYGLGSSVFTSDIPRALRVASKIEAGNVGINQAYKTSPQTPFGGVKQSGYGREGGYEGLRGYLHSKTITINMEVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEI5</accession>
    <name>A0A0D2BEI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_04176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237201.1">
        <property type="nucleotide sequence ID" value="XM_016378524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEI5"/>
    <dbReference type="GeneID" id="27331259"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04176"/>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000107">
        <property type="entry name" value="Mitochondrial dicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="116"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="211"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW16985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33363" checksum="61DA0D9B470C42DC" modified="2015-04-29" version="1">MSINTADEWKAAATLQYPFWFGGSASSMAAMVTHPLDLVKVRLQTRTPNAPKTMRGTFTFILRNQGLPGLYAGISAALLRQSTYSTVRFGVYEDLKTRYAASPTPSNPRPNLPMTTLIALSSLAGLLGGIAGNPGDVLNVRMQSDASKPAELRKNYKNALAGLIHMIREEGLSSIWRGVGPNSARAVLASASQLASYDYFKSICLSLNMLDNLTTHFCASLAAGFVTTTVCSPVDVVKSRIMSSIGSQLPILQMIRDAGRKEGLLWIFRGWVPSFIRLGPQTVFTMAFFEQHKKWYRQWKGCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BER7</accession>
    <name>A0A0D2BER7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237311.1">
        <property type="nucleotide sequence ID" value="XM_016378634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BER7"/>
    <dbReference type="STRING" id="91928.A0A0D2BER7"/>
    <dbReference type="GeneID" id="27331369"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04286"/>
    <dbReference type="HOGENOM" id="CLU_090139_1_0_1"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="151" mass="16865" checksum="9882BD31E072198E" modified="2015-04-29" version="1">MGRLHSKGKGISASAIPYSRSVPTWFKSTPETVVENICKLARKGATPSQIGVVLRDSHGVAQVKVVTGNKILRILKSNGLAPEVPEDLYMLIKKAVAVRKHLERNRKDKDSKFRLILIESRIHRLSRYYKTVGVLQPNWKYESATASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BG95</accession>
    <name>A0A0D2BG95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_02269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW17983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238199.1">
        <property type="nucleotide sequence ID" value="XM_016376629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BG95"/>
    <dbReference type="GeneID" id="27329352"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02269"/>
    <dbReference type="HOGENOM" id="CLU_028200_25_4_1"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="48"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="424" mass="47336" checksum="AEB8BA586C03FC10" modified="2015-04-29" version="1">MTISLHLPPEVLATWPTPNYINPPTRGPGLEVVSILFSIVGLAVVATRIYSRLLITRAPGWDDFLIVVGLAFSIAASVMTTIGNKLYFSGRHIWDVPPSTFTPLRLNVWITEWLVVLAGTAIKISVLLFYRRLSVKFPRGFLIATWVGIVYMILYVLAFTLTLLLICRPTDSYWNSFTPNWAATHKFHCADQSVSIPSAVGLSVLGDFYTTILPLLLIYRLKLPLKQKLALYSLFALGFLACIFGVIRLVLLNKLLNDTFDFTWLLWEMWIWSVVELYVAIFAASAPALKPFLQRFLSISTNGIARISRQLHVDKGLPVPTFRFGSHSLSNMTGSSEADVESVGGANIGGERGVRGRGFWRDQGHRIIHHFHKRPSQGHQITSAHVTEQNSASAFHRPSSKPENWSSKVTTLDKPLPLPPTSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGH5</accession>
    <name>A0A0D2BGH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230655.1">
        <property type="nucleotide sequence ID" value="XM_016385711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGH5"/>
    <dbReference type="STRING" id="91928.A0A0D2BGH5"/>
    <dbReference type="GeneID" id="27338486"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11403"/>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF24">
        <property type="entry name" value="HYPOTHETICAL FRUCTOSYL AMINE:OXYGEN OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="439" mass="49226" checksum="3E0D64702A0EA4CA" modified="2015-04-29" version="1">MSQLSHDSSILVIGGGTWGCATALQLARQGYKNVTVLDAHPIPSPISAGNDVNKIMEEGIPSEDDDEESYVWNRLFQLATEAWKSDPVYSPFYHATGFVMAASSPEAGKHVDSYIKSCKSPIRRLDTPEAFRATMPPGILTGDFPNWKGFIRPEGAGWVFARGALEAAYNEACRLGVRFVTGESKGNVERLVYSDSDVLGALTSDGVEHRADRTILCAGANSDRIFDFEKQLRPTAWTLAHIQMTEDERVQWRDLPVLFNVERGFFMEPTTRTGELKFVDEHPGYCNFIHDHSINAERSVPLARQQIPVDAEARARRFLRETVPQIADRPFTFARVCWDADTPDRVFLIDQHPKYSRLLVAVGGSGMGFMTMPAVGIQVVNALEGQMEPQLKKAFRWRPEMAVGRDWRDTQDRFGADGEVMDLQQVKGWTNVDNSRQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGU2</accession>
    <name>A0A0D2BGU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238061.1">
        <property type="nucleotide sequence ID" value="XM_016379384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGU2"/>
    <dbReference type="STRING" id="91928.A0A0D2BGU2"/>
    <dbReference type="GeneID" id="27332123"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05040"/>
    <dbReference type="HOGENOM" id="CLU_580071_0_0_1"/>
    <dbReference type="OrthoDB" id="5207033at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="471" mass="53840" checksum="65418AF142B0AA3A" modified="2015-04-29" version="1">MAYRNGRSRYRSEVEAEAASRSIALSDLSQDLDGRKAIVFLEWKKGDAIAAATVPQINSSIPELYPGFDKITEVFDVPDTFLEERLHHGAYSFGSARQGHLQRIWSHFLLKYIGTVDFLDADYESSLWSKSSFLLSWDTRTGFSSLDDSASSPTASGLQMAQVTLICFGAFQDLKHQFDSLRFSNSWEVVLQDPHLLLTYIYDSWYKRVDKTVWFANGRGRGIEEASHSVSVIPKSKKADMNQQAVRETSDKVLTKEESKVNLEHLYRITQTVIYLREGLDATIASLSLAAEHCRKSPRQKDSHLLRDNVLSQLQYRREMLRSTRLRLISLHERLKNINEISYHLVARRDSYAAQRISEHMKKESSRMAVIAFIGILFLPTSLVASVFGAVHDQNYTMQKAFAKFGYLVGAAVPLTLLTVFLYRLFGETESRPMAERSDNGRNEGFELRSFRRRMWGRRTVSHMAEDGDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIT8</accession>
    <name>A0A0D2BIT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_03137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239064.1">
        <property type="nucleotide sequence ID" value="XM_016377494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIT8"/>
    <dbReference type="GeneID" id="27330220"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03137"/>
    <dbReference type="HOGENOM" id="CLU_032067_2_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56131" checksum="FF4D2FF57D4FB76B" modified="2015-04-29" version="1">MNGSLHPSKEQAFWDVIIIGAGISGVNAAYRLQTELPKYTYTILEARPRMGGTWDLFRYPGIRSDSDLITFGFAWNPWDKKNPIADGPSILQYMKESASQYGIDRHIQYETSVASASWSSEDALWTLSVSVNGQTTFVSTRFLIFGAGYYDYHTPLAATIPGLENFKGQTIHPQFWPENLDYSGRRVVVIGSGATAVTLVPELAQRAASTTMLQRSPTYIVSLPNKVRTRPWWSRLMPRFLFTKLRRLFWIVRGRFVYNWCMKYPEKARALFAKGTIRQLPQSIPYDPHFKPSYSPWEQRLCVCPDGDFYTALREGRANVETDTIEGVVEDGIVLTSGKKLDCDMIVTATGLKLQFAGGVRIEVDGEPVEIHQKYWWNGAMIQDIPNAAFVMGYPNASWTLGADATAQFVCRFLKALERKKQRAAAPYLEDAGSLKPTPSLALTSTYVRLGSGSLPKASLDAPWVGRRSYFEDVFWAKYGNLTKGLKFISTAATEKKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK86</accession>
    <name>A0A0D2BK86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_10996</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231910.1">
        <property type="nucleotide sequence ID" value="XM_016385308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK86"/>
    <dbReference type="GeneID" id="27338079"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10996"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="519" mass="57175" checksum="C366B3A578D3E2FD" modified="2015-04-29" version="1">MNTAPTFLGLRGQPLIYAVTFTSSIGFLLFGYDLGFMGGLTTSEKFLKVFGNPNSALLGFIVASYEVGALFGALFQFAMGDRYGRKTNGLAGAVVVIIGAILQASTTELGQFLVGRIIGGFGLGCMTTVIPVYLTECATRTNRGRMMAMQLSNLIIGLILANWLDYGMADYSSSFSWRFPCAFQIVFCVIVCCLMPFLPESPRYLFRSGQVERGTTSLAALRGTTREDESVQLEIKEIQYILEVESEEVGSWSDCFKDGGMYGWQRVLVAFSANFFQQLSGVNVISSLGPYVFQNSIGMSSRDALLVSGGLQVYYFLSSLIPWYTTNNVGRRKLFMIGSAGMGTCMLLSAIFVGVGSKGLGYAAAVVLYIFHTFFTLGWQSNMWIYPSEILPLKLRLRGGALSVVSQWLFTFVVVQITPPMITDIGYKAYIPFACVNFFTIPCVYFFYPETLQLPLEAVDLLFTGRPGEARPSYMQAVRNSTKKEFKDEIMATLIERADQDGEEAGIKLGPVHQETAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLB4</accession>
    <name>A0A0D2BLB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239586.1">
        <property type="nucleotide sequence ID" value="XM_016378016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLB4"/>
    <dbReference type="GeneID" id="27330748"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03665"/>
    <dbReference type="HOGENOM" id="CLU_039650_0_0_1"/>
    <dbReference type="OrthoDB" id="4109707at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39248" checksum="733B6B0ABC55A9D1" modified="2015-04-29" version="1">MGNKIDQVDVSSGIFVAGVNLWSVMLEVDNREARLVEAVVAASFLATYGQMSVGWNNWRNASTILCNAVTADIEALTPDRRVLTAVPAYALVSYIFLIDTLQATHCGLAANISTKELFIKLPGSDHQFCAIYHSLLQGNQIPQDVHNEEDALLLLTALLSDVVYAQRCLQLMSSTTSGLLVHGCLMPRSPFTPLSAASEFSRLNEAMTAGLSRWERIFENHVGKDILALQCFCKLQLICPDTWKLPQMAGYGETQSEGECLRPSERFEVSDKAAALAWQVLNCCHHLPSESKLAVWLPVIVFLCALTIWQKLRTEPSHYGSLRVLDLFSKEIAGYHWPCSIEMVRTLERLMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLR4</accession>
    <name>A0A0D2BLR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232330.1">
        <property type="nucleotide sequence ID" value="XM_016383707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLR4"/>
    <dbReference type="STRING" id="91928.A0A0D2BLR4"/>
    <dbReference type="GeneID" id="27336471"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09388"/>
    <dbReference type="HOGENOM" id="CLU_005723_0_0_1"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000354">
        <property type="entry name" value="UBA domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="235"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="886" mass="96470" checksum="3D09A71A668E62DC" modified="2015-04-29" version="1">MDDIAGLKWTSTPANGQPRTTSNYNAFSTFKPTPPNSGRATPLDASSATQPRAKSTTPVSDSFANLVSFGPGANKNLSLVEQQKRQAETRLEQQQKTTQSIHDQYAGGDDQFWNNLGSGRGTPVVDGPNVASRNLPNNTRNDNNDEEDDLFAAFNKPAPRQNQPLATSSNDNVKNNEEDDPFELLNSASRRTDTATTATSADDDDVLGLLGEPASVHLKADRLPREEDSHAEDIHPQEKAIAELVDMGFPADKARLALETTETGTDVQAAVGYLLNQAHAEARQKSLGRDSHQPDHDREGRLKNGQADQESSQRRTRRDDGSGSRSRPHGRPGASDKDFEQMAAEFGTNFLKTAGSLWKQSTKRVQQAVQDFNADGESSSQPRWMREAERPHRIDHQQHPRYVGSGMTDPSRRVPDGQKPSDVTDEALMLESDRPAPPPRPTVSSRTDRWLDPSADSSRDHSPAIPHRLRESLPQKQPAFLRQQTPSPAATSRAALNRATADEQAAQAYVSSARRRRAPASEQPVDPASEPDLLDGNFKATSEPQPAPRTAARASPPARSQPQPHRQTGMAVRPPPPSRTIPAVSAISLQASHSHREKGNEHFKRGDYSSAHTSYTTSISHLPDSHPLLIVLLTNRALTALKIGEPKTAISDADRAMTVIGNSKGENETINMATGNGQDNKPMRDYYGKALMRKAEALEQMEKWSDAALVWREAVEGGHGGATSIQGRMRAEKAARPQPPKAPPKPKAMSRPSPMPAKAASAPPAAAVNRLRAANLAAEKADDEKFRLSDSVDARIQAWKGGKADNLRALLGSLDNVLWEGSGWKKISMADLVLPGKVKIQYMKGIAKVHPDKIPTDATTEQRMIAGAVFSALNEAWDKFKTENGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM94</accession>
    <name>A0A0D2BM94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239941.1">
        <property type="nucleotide sequence ID" value="XM_016374665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM94"/>
    <dbReference type="GeneID" id="27327382"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00299"/>
    <dbReference type="HOGENOM" id="CLU_400627_0_0_1"/>
    <dbReference type="OrthoDB" id="4121314at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="687" mass="77353" checksum="EC37B9D59DD1A5F6" modified="2015-04-29" version="1">MTPKTSADANKPAQDCSTTPAGRVTAVEVSNPPERMPGKSTGKSVQTRRMQHGVEAQSSRSRKIKFPLTLEKSHEKIQVLSDQLELKRTEITKLKDAKKRSQEQKTALSDKLKAEKEKRQKIGDDLQKLQHERFENAVSHELPPIPDEEVHAYLSEIFINTKILSKQWAVGKWDQIDEKRQSEIFMEFESRFGKPLCSDRMKDVIRKGEIPPHIIVNAAINAALCNETFSRPFGWLRGSSSKLENGAGEVFLAWLIETATADSHGSNHIVQAKILRAIDMPFAVDHWSEGTRCSPAIRRLRGEYIESTCSTIVQLCRPFLKSLGDITESRRRTELLDIVRECHILSSSLTLQYSRVKILFWNELQDRCFATDHKDLEPHRGMKLKECDDDDEGRDPKECGIDGSPIDLAVSPLVIRIGDTGGLDQTIRQNIKKAVVWVLDPGKVPVTTPKPTTNQADGEAINHHPMSSETTPLYALQSPNSEREQIQMHGQTAQNRLAEEIRPPTPVADCQFIGRSLTAGASDDKFSQQEPHLQSNTHNTQPGHGHDGHPVIKREQTDDLVLLSSGVENSQVPSKSKKLFTEPGRMPTNSPQQDRKKRNRQSHPEKRQRRGARTFEDCSSNESADRDDSGDYEPGAPWQNLNPPKRPRTSSKGQTRGPGEDTVQQRGYEEEDTGTKDRSYKQKLRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNB5</accession>
    <name>A0A0D2BNB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240644.1">
        <property type="nucleotide sequence ID" value="XM_016375368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNB5"/>
    <dbReference type="GeneID" id="27328086"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01003"/>
    <dbReference type="HOGENOM" id="CLU_024934_5_1_1"/>
    <dbReference type="OrthoDB" id="5295362at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="53679" checksum="2DC58943C988B8A7" modified="2015-04-29" version="1">MGVVVVVTVPSPLREVHTRRSQCWCDEISPICANCARRELQCSFLTDNDETTPGNGASQSPAAQGPPPRPRSNPASSTLRAQPPTNHLQTAAPPGLLPATSATVLDPQIQARHMLELELMHHYSTSTYMSFFGLRDHVATVNAWQRFVPREALKYDFLMYGLLAFTALHIAKLTRPADDKLDESTAMDTDADADADADADTDTDGVGGGGSGGGGGEATFSAPSSFYFQKALEYQNEAFRSFRSVLDHVTQDNCNAAFAFSVLTTLLVIAVPGFEDGSEKEDGTSNKTMQAVFTMFEFLKGLSSIVAASGEWFHKGPWAHVLAHFQEFQEGHWELSDPDCLQVLRRLSSLNEELNDPADPAEGSKFRVNKCAIDNLERCFAKYHVPAVVRGGGGGDDVAGVGGGERDVAYKGHILGWLTMAGSDFVTSLHRGDSLALLIFLHWAVLLKNLESFWWSHNSAKALVAEVASMLHPRGSEWEHRTMWAREKVGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNT4</accession>
    <name>A0A0D2BNT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240769.1">
        <property type="nucleotide sequence ID" value="XM_016375493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNT4"/>
    <dbReference type="STRING" id="91928.A0A0D2BNT4"/>
    <dbReference type="GeneID" id="27328211"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01128"/>
    <dbReference type="HOGENOM" id="CLU_076384_0_0_1"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="199" mass="22102" checksum="FE80A55698A3D40D" modified="2015-04-29" version="1">MANPLLSVNSSSPGFEPTHQTWDAVDFSLFESFTDYGNLSLSPAHGQPSTGPDNSQQPTSKARRRAQNRASQRAFRERKDRHVKGLEYQLETLNEKHQDLLTSYSKQADNIARLYNRITDLQDQIRKAKVTNDHGVVSQSTNSNPTPDCFDAFTFGGNPGSMFFSADEFNSDEIGQEDSLTPKASGSAGLPLFEDLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNZ1</accession>
    <name>A0A0D2BNZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_00825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240466.1">
        <property type="nucleotide sequence ID" value="XM_016375190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNZ1"/>
    <dbReference type="STRING" id="91928.A0A0D2BNZ1"/>
    <dbReference type="GeneID" id="27327908"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00825"/>
    <dbReference type="HOGENOM" id="CLU_014304_1_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF105">
        <property type="entry name" value="ATPASE EXPRESSION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="703"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="794"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="813"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="851" mass="95784" checksum="738387624C886DC6" modified="2015-04-29" version="1">MFTCSACLLRAFQSLSVDTSTCANPRFPVRAAAIFRRNHATLQSVQQGHHRRLLTKTLRAEKRIKGPSWRAEPAVARAASRDAEARRNNRLRLMNNHGKTEVQQSARRELQYLSDPLKLAQTVADKLRDSKFDAALNLVRESDKGVGISRVNIDNTVSWNHLIDWLMQQRRPKDAWKIYNEMKKRGHKPDAHTYTIMLRGYRENYKQTGVVEDAIKVYNSIGAANSAVKPTIIHTNAVLNVCARALFIDSMWVIAGKLPEQGPGAPDHITFTTILNTIHSEVRHRAVKLGASSPDGDYDPQPIFEEAVNDARKLWVDIVSRWRRGLLHLDEQLVCAMGRVLLLSSEPKAYEDVVNLVQQTMGIPRYAGDGTSDKEIEDRRMLTAGAIDELEEVAPSSTDITPRTAQSMPIANIDSSIYAAPGKNTLSMLLEATTALRQIGAGKYYWQLLTSPKGPYKLEADRANIISYMRLLRVSRASQATLDLLLQPRPADVQQQLMSRGTFIIAMSTCYRDKKNPNVFSIANRIIKLMEDSVEAKASEDENQGIWLKFAPSVLEKYLQLALATTKGLHGEPLAKTKEGDLDFERDPSKNNTFVALEKLKPEVTNIMRLIKSHVTELERLQDVKARTKSVQTLLDKRRITPYSVMESMGPMVDFLRTVIGAYDKILRVNERLEDDGMGPLDSSIIEECWSKKRRLAAFLGKVESMTDQSPTGGTAAKPPSRTSSEDEDGDDDGSVVDGTSNRRLDDHYGQRARTLKSIKAARSKVEKKREERNLSRIQKRELAKEERIRAQFPQSVLRPTQDRGPPRKKKFELKGSQRDGTEEKNYKGWGSGFQDLVKSTGKGDVVDLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP36</accession>
    <name>A0A0D2BP36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233085.1">
        <property type="nucleotide sequence ID" value="XM_016382382.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BP36"/>
    <dbReference type="GeneID" id="27335139"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08056"/>
    <dbReference type="HOGENOM" id="CLU_000129_1_0_1"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="6">
        <location>
            <begin position="2626"/>
            <end position="3181"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="3431"/>
            <end position="3763"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="7">
        <location>
            <begin position="3775"/>
            <end position="3807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2003"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3193"/>
            <end position="3261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2003"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3193"/>
            <end position="3208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="3209"/>
            <end position="3225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3249"/>
            <end position="3261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3807" mass="433997" checksum="7329575CB37A646A" modified="2015-04-29" version="1">MDASQKIDHYAARLSDPKTGKSSSQSHLSTDLRDSIETLCSPPALFTKFLSKLWPVFKKILEGKPDFNPFSFEHILRNQILEILYRLQHGPPEVEPYALDMVDTLMELVRVENEDNAVLCLKTIMDLERHQQQATASKVQPFLDLIQEMFEMMDQVVRDTFDSPAPHSQGSSSTPIPPGQNLQSPRPGSPATTVSDPGAEKREQHPLVKGMQSFKVLSECPIIVVSIFQAHRNSVPANVKKFVPSIKGILLLQAKPQERAHAEAAANKTIFTGVSREIKNRNAFGDFITAQVKTMSFLAYLLRVYANQLTDFLPSLPAIVVRLLKDCPREKSGARKELLVAIRHIINFNYRKVFLNKIDELLDERILIGNGLTVYETMRPLAYSMLADLIHHVRDSLDRNQIRKTIEVYTKNLHDNFPGTSFQTMSAKLLLNMAESITKLENKEDARYFLIMILDAIGDKFAAMNYQYNNAVKLSKQYIEKAKDTQPESYMDDKNEVPDWDEVDIFNATPIKTSNPRDRGAEPVVDNKFLFKNLVNGLKNMFYQLKTCNPPGLNVDQASVPMNWAEVSFGYNAEETRVITKLFHEGARVFRYYSAEAPTPDLQYSSPVDFMASHSMAQMTREEKELLESFGTVFHCIDPATFHEVFQAEIPYLHDLMFEHTALLHLPQFFLASEATSPAFAGMVLQYLMDKLPEVGSSDIVRSSILLRMFKLSFMAVTLFSTHNEQVLLPHITKIITQCVQLSVTAEKPIHYFILLRSLFRSIGGGRFELLYKEILPLLEMLLETFNHLLQGARDPHDRDLYVELTLTVPARLSHLLPHLNHLMRPLVVALRAGPDLVGQGLRTLELCVDNLTADYLDPIMAPIMDELMAALFEHLQPQPYQHFHSHTTMRILGKLGGRNRKFLNHPHELAYRRYTDDEPSFDIRLIETSRDRAFPLDTGVDLAIRRLSDTAKNPSKKSVDLYYKQQSFKLIVNQVKLLIGFDNLPDDFAALLRLQANDLVSRRFSTYADMLADNELGKSVQKRREQEESLKKLLKACFAATTIPDLKSQAESFITNVSRHFTIVELGQALCDAGRKTKEFDVNSGEGAVHLSTRTLADVICHCLASDNVTIREAAEASLLVIVDTARTIFGSEERAARLPFFSHLISTFCHRCREVEWFTKAGATLSIQLVITKLALGNAFLHSKQLEIIRALLFVIKDTPQEFPASTRITAQETLEFILRKVCVGQTREMLVNEKSTIHALSVTFSVELSHMNKHARETAQRAFSTMAEVVGVDVHELIAPVKERLLQPIFNKPLRALPFLSQTGFIDAITYCLGLGHDFVPLNDQLNRLMMESLALADADAEILHPKPDEYNNAQLIVNLRVSCLKLLSLAMSLPDFATGPQNTSRARIITVFFKLLYSKSPEIIDAANAGLEKVLVQTAKLPKDLLQNGLRPILMNLQDSKRLTVAGLEGLARLLTLLTNYFKVEIGARLLEHMKVIAEEQLLQKVSFGLIEQNPQMKIVTAIFNIFHLLPSAATSFMADLVDSVLDLESKLRRTVASPFRQPLILYLDKYPQETWAFFSSRLQEEKYGRFFGQILASDLSANLRKFVMTESEALTKAAFETEEGQDGNTAAINGIYVIHSICSFDAAKDWLREQPQLRAKVLSAGRELEGQLRADTLQPQQRLRVEQTGDRVMDILTSYLSSAPEDLDFMMEVFSASAQGEIKTPLKLTQYLFGSVITDDSTQRRFNVIDRCLEVYAQKGISQKVKTFLLHNVVNPIMARDLQNTRRENNQAGSLSDAKLFSLISDRLWKPLALDSEDSSQPGIDHSRMEALQLSAFILKYHKDAVSEDRKDIIKYTWGHIKLEDVINKYAAYVLICYFIRAYDTPPRIAVQVYNQLLKAHQNEGKALVTQALEVLAPVLPVRMGANAPGDNRAPHWARLPRKILNEETGNLQQVQSIFNFIVRQPDLFYESREFFIPTIVQMLHKIAPPPNPSNENKKLALSLIGLIHQWESRRISEGSSVQSNAELTPSRKRDSSGTPNLAPPSTAERPEYLIPIELRTLVVKYMITFITSLLERYPVPAAELKAKTMQKAQQQPLPNEMCKKAVQLLRDLLAPNLWADVDVGLYEKLLDPILSGEKADKADEKQLTCMINTLQVMRILLGTKTDEWIVNHMEKIQNLLEKPLKMDDPEIQDCLHFVTDDDKTLPLVRRVLEAIPKQRNEDEDTMELDSNPTDFPTRYSKVLIGEALSSGNYTSAINNLWTLSVVRPAEVDDHIAGAMKALQQKLAKDHINAYIIPPGPPPPGWRMGEPLMDPYEFALGVDLIKKTIDILSSRMGELNEQRRPFLSVLASLVEKSFNVEMCGKVLDMVEKWVFNSSEPWPTLKEKTAVLHKMLIFEKWQNQTLLERFLELVIKIYEDPTVTRTELTVRLEHAFLIGTRATDVDMRNRFMNIFNRALSRTASYRLNYVLTLQNWDTLADSFWLKQASHLIMGSVEMSMPARLHPEDIRVCPLSSLFSPSLVNPEQGKDDLLIEDSLEALVLAQRRFNQDIQEVKVRDLLDPITQLQHTDDNVAYDVWVKLFPLCWSALNRDERLDLEKGMVTLLTREYHQRQLNLRPNVVQALLEGAVRAKPRFKVPPHVLKFLSRTYDAWYTALVSLEESTVDPLIDTPQVRESNLDALIEVYAGLQEDDLFYGTWRRRCKFMETNAALSYEQHGMWEKAQQLWEAAQVKARTGVVPFSQGEYYLWEDHWMICAQKLQQWDILGEFAKHENFSDLLLESAWRNYEAWAGDENRNQLDSMIKSVSDAPTPRRTFFQAFMALLRYNSKQVSRAEFQHVCDEAIQLSIRKWHQLPRRLTGAHIPILQNFQQLVELHDASVICDSLMSTNERNLDNKSQEVKLLLQAWRDRLPNIWDDINAWQDLVTWRQHVFQLVNSTYLPLLPQGGNNVGNNSYAFRGYHETAWIINKFAHVARKHQMPDVCINQLGKIYTLPNIEIQEAFLKLREQAKCHYQNKSELNNGLDVINNTNLNYFGAQQKAEFYTLKGMFLAKLQHAEEANEAFGVALYYDLRLPKAWAEWGQYSDRKFKENPSLIEAASNAVSCYLEAAGLYKSAKSRKMLSRVLWLLSLDDEEGHIAKAFEDFKGETPVWYWTTFVPQLLGSLEHKEARLAKSVLVKIAKAFPQALFYNLRATREEFLTKKKQFEAQKRQQKAIQDKLEKSENGSRPGTANGETATQESASPKPKQEPNGDAQASGAVNGVAEAETKEEPKKPWDHTDEIMAGLKTAFPLLALSMETMTDQLSKHFKCPPDEDAHRLIVALLNDGLAYISRAPITYAEGAKLPPSTEANIARFVTSVLPAHIRKSFEADFVQTKPTMYEYIHKLRRWRDKFEQKLDHRQQWAALEAYSHHLSEFKFLKFDDSVEVPGQYQQHKDKNTDFVRIERFMPTVELVRGNSICHRRLTIRGHDGSLHPFAVQHPTGGKVRREERIVQLFRIFNQTLAKRKESRRRNLYFHLPIFVPIAPYIRLVQDDASYVTLQSVYEDYVRKAPGMSRDDPMLFLLEKSRTIAEQQKTQPRTHDQVAVMKTEIFNTIQERWVPNTIALRYFQDIYPSFADLWLFRRQFAYQFAATTFMTYIMHMSARYPMKFSISRSTGDIWASDLLPNLNSARAYFYNPEAVPFRLSPNIQTLMGPLAVEGIFTASLMAIARCLAEQDQGYEMEQQLSIFVRDEMYNWAAGRSNSSNDTKMEGQHLRELVAQNAEFIVRRALALSKTQGTVGAAGGEGAGVTGVLPACQNVVDLVSRATDPMKLSSMDGLWMPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPD6</accession>
    <name>A0A0D2BPD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240596.1">
        <property type="nucleotide sequence ID" value="XM_016375320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPD6"/>
    <dbReference type="GeneID" id="27328038"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00955"/>
    <dbReference type="HOGENOM" id="CLU_094667_0_0_1"/>
    <dbReference type="OrthoDB" id="4223044at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="177" mass="20603" checksum="D7E47A635F70CF78" modified="2015-04-29" version="1">MLLRRTDTDATSAARDANGQQKVNNQMADSQRPLTCMFYFFASQMKRNIQRADEDLVQRGKLPDEPIHRLDTMIARLRMHAAYSPHITKFETYPVEIPDAAPTWLKRPPRPSPEEVHDTVMLMKFRNKGAREEWIATKEWQEFMTKTEGEQVFRRMPHVRCASSLRGLMDPVDILTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPI0</accession>
    <name>A0A0D2BPI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233200.1">
        <property type="nucleotide sequence ID" value="XM_016382497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPI0"/>
    <dbReference type="STRING" id="91928.A0A0D2BPI0"/>
    <dbReference type="GeneID" id="27335254"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08171"/>
    <dbReference type="HOGENOM" id="CLU_025946_1_0_1"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000929">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="533" mass="58220" checksum="1E0B318624F9A4C4" modified="2015-04-29" version="1">MLTESFIAATLTANPPVAHGSAALRDVGIFLHEFQPHRGFRHGYKKSSSRSGCVAISSSHIFAAQADKAVVNIYSRERGNQEATVPFPERIHSLAYADGAEILVLGTEGGKLILWEIATGRSITSSASHLQAVSSICITPNNEYILSGSADTTIHVWSLLKLVSFVQPAGTYASDEPSHLPIQTFSAHRATVSAIACGHSRINTNFAVSASSDKTCYVWHIDSCQVIRTLLLPSSAISVTIDPADRAIYFGCDDGQIQSFDIYQRKDQIHASRTHSSEFPPIQLLPKDSWLAPSSDIGATNCLTLSYDGTSLLSGHRNGAIISWDCGKHRITNEVANLGQPITSLRMLKPEGLPRRNTPSYIISNIVKPNLDLAASKDNGSCGIPAKYNIQVKLNTAKSAQSDGQINQAILGHGFPQDLFDDALRSLTAGNQGTTASSLDSSELGKVERLEDEVSRLKEQLKVLHNVEKKRKERNLAKLKRQDELDLEKRKVYFEAKKKGQDGDFAIKQFEERRGLLEVTSDGDHSDVQMDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR25</accession>
    <name>A0A0D2BR25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_02028</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241664.1">
        <property type="nucleotide sequence ID" value="XM_016376388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR25"/>
    <dbReference type="STRING" id="91928.A0A0D2BR25"/>
    <dbReference type="GeneID" id="27329111"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02028"/>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW21448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="459" mass="49424" checksum="E1174847C8CB5166" modified="2015-04-29" version="1">MWLTTLLFPAAAAAITLDINSRSSIASAAGTAAYNMMTYYTGNQTGQVPGDLPGSLSCNPNVAGTYCWWEAGAMWGSLINYWQYTNDSTYNSVVSEALQFQRGPENNFNPPNQSRSMGVDDQVFWAFSALDAVESNFPEASDGQPSWLSLAQAVYNFQTSLWDTSTCGGGFHWQVYSFNSGYNLKITIANGGNFQLSARLAYITGNSSYADWANKVWDWMASSELFETSGGMLYIWDSTDSDNNCTSADHYVWTYNYGTVLAGAAYMYNYTNGSSVWESRVQQILNSTFSLFFPSEYGGNIMSEIECEPHLNCDQDQKSFKAYLSRWLAVTAVLVPSTASQIMPKLQGSATGAAGQCSGGGNVCGEQWYLTTYDGYTGVGEEMSAMSVFGANLINSNMAPLTLRTGATSKSDPSAGGSATGGPASLVEKPITTAGRAGAGILTVIFCVISIGGAWWLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BS53</accession>
    <name>A0A0D2BS53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_06810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234245.1">
        <property type="nucleotide sequence ID" value="XM_016381143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BS53"/>
    <dbReference type="GeneID" id="27333893"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06810"/>
    <dbReference type="HOGENOM" id="CLU_086407_2_1_1"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="GRPB DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822:SF1">
        <property type="entry name" value="GRPB FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26071" checksum="449E7CB25A66950C" modified="2015-04-29" version="1">MHFHDNDGHVGCYVPGGTGEGSPRISNAAPLPVVKVVEYDPSWPSKFQEISQKLEHYLSISGVEYTSIEHVGSTAVPGLAAKPNIDIIIEVPNAEQAAKAKEALIHEPSPEEHYKCWGDGGIKGRISMKLHNRNELPDQSVYIINQEDPEGRLVVQCHRALRDTLRLPQHEALRAEYGRLKVHLATSSIDGVDYGQKKNPLIRRILQTAGWADEEIDKKEALDYRIPGDDDLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BUX7</accession>
    <name>A0A0D2BUX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerol-3-phosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235215.1">
        <property type="nucleotide sequence ID" value="XM_016382113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BUX7"/>
    <dbReference type="STRING" id="91928.A0A0D2BUX7"/>
    <dbReference type="GeneID" id="27334869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07786"/>
    <dbReference type="HOGENOM" id="CLU_045011_13_4_1"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26029" checksum="9F7111B072AEF158" modified="2015-04-29" version="1">MGSVEEHSFSGPPQVLSAGGLLFDFDGTIIDSTEAVVKHWHKEAAAMGVDPEVILATSHGRRSIDTFMEFDPSKANWEYVNRQEGLIPKLFGKDAVEIPGARKLLDSLEAVNAPWAVVTSGTSALLNGWIEVLKIAHPRCLVVAEDVENGKPDPSCYLLGRQRLGLPENSPMIVFEDAPAGVRAGKAAGFKVIGLATTHRISQLQEAGADWIVEDLKSVTLKGLEPDGNVQIEITNTLVQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZD7</accession>
    <name>A0A0D2BZD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236900.1">
        <property type="nucleotide sequence ID" value="XM_016378223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZD7"/>
    <dbReference type="STRING" id="91928.A0A0D2BZD7"/>
    <dbReference type="GeneID" id="27330955"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03872"/>
    <dbReference type="HOGENOM" id="CLU_008451_0_0_1"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="691" mass="77733" checksum="CB3EC32923468567" modified="2015-04-29" version="1">MDAGAVVISWHQAFEEHRIPTTRAIEKQLRANASRDKEKLRGLVGGCYREFLATAEAIVALEEKAQVAEQHISSISHNCRPPEYDLARRQLPTEKVTLAQFRLLQRCYTTSVTCLQNLDTLKCSKLTLLSRLLLRSLDNENSLSSSLEHMRRKVGALRQRLLRQVNVILVNPTSTIPVLVDAVCSYCLVTDASSSKALDHLHDRRLDKLRLQLDGTSERSAICEALRYQLASLQAFKTLTGHSVSEAMNMLQRKAILADPAVRELESLDLDRTWPLLPEEIQTFVPYFQRTSSTSEEAHAKLEAWSKESSGILEKAVNEHLAQFTDPAEVLELRRELFTLLLPVYFSTPAGKDIGKCIRKSLNDHMSAICQDHGSRLNKIAEELVSASQSSTLGSSLWSPQTVQTHSDRGGLKMIRRLKARHLGLNKSLSNATKALDDWIAGIHVAKDQINELSKTRWRDMIEEPDEDQEDEATLEIRMLGKDDPDYYNKSLQESAQNAVSEYESRLAAAASEAVSQPKDLSRVVYVVRAIRISAAVLSRTFEDETQESKLDEKMHDLHKVIADEVVRQLSEASRDTNRRSKRDINQLPDGMPSPKAFMALRRLCRVMADIGGTDLWTIPAVALVKKAVAAEIFDPEWKGNYLETDFDETFLRAALQDVADVTKSKATETEKTKSAIEYWSRTKLLFGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0H7</accession>
    <name>A0A0D2C0H7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237355.1">
        <property type="nucleotide sequence ID" value="XM_016378678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0H7"/>
    <dbReference type="GeneID" id="27331413"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04330"/>
    <dbReference type="HOGENOM" id="CLU_030884_0_0_1"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="52286" checksum="074031040AE009A4" modified="2015-04-29" version="1">MAFKIPGLPPVRLHSPYWQNVIIGILVGLTAGLYVALNLLGAGGGRPNAAQTVQVVNATLCAVWFFSASFGGTVLNKIGPAITASLGVLGYIIYVGSLWYFDQTGKEGFPIFAGVAIGISAGLIFVTMGYIAMSYSEEQDRGKYITVSINLQAVGAIVGGIIPLLINRNSTEAAGVPPAVYIVFIVVMAMGMIGAFALMPPDKIVRDDGTKVGVVQARTFVEELKANLEIFRDWKLLIMIPAFLPAECFLVYGGSVNAYHNNLRTRCLLSFISVVLQLPAGWGLQWILDNKKMKRRTRAFIGLAVVGIPLTGAWIWEIIRTRNYDRSSPPEHPMDWTDDGFVAIFFLFMMNWVFSSLWQYIILYFLGTLTNSPRKSANYAGVFRGILGAGEAICFGVDSIAVPYMKEAAVIFAFYTTGVLVFAYLAAFHIRETEYFNGEDDVVIPKHVLEEHELDSSSIAGEKVPIEDQTVTIGDNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C210</accession>
    <name>A0A0D2C210_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237905.1">
        <property type="nucleotide sequence ID" value="XM_016379228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C210"/>
    <dbReference type="STRING" id="91928.A0A0D2C210"/>
    <dbReference type="GeneID" id="27331967"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04884"/>
    <dbReference type="HOGENOM" id="CLU_031618_3_1_1"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000033">
        <property type="entry name" value="Thiosulfate sulfurtransferase TUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="85"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="217"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="344" mass="38774" checksum="A0704C6273D0B0D9" modified="2015-04-29" version="1">MVTSILARPLWRQQAPLLRVGTLHQKSFIFQRQPFSSYFVTPKEVNEALSKNAPTAISTDPKVVPICAAWFMPNDPEKRTGLEVFKKKRIPTARFFDIDEIKDKESEYPHMLPTCDEFADAMSKLGVRKHDELVIYDTEELGLFSAPRVAWTMRVFGHPKVHVLNNFRLWVKEGYPVETGPPQVPNITKYPVPSYNTDMVVKFAEMKTIGYDYGKEGAEEIQILDARSKGRWEGTDPEPRPGLKSGHMPGSTSLPFNELLDPETKALLPKEELIKIFEAKDIDSKKPIITSCGTGVTAAIIEAALKEADFGTENDRRLYDGSWTEWALRVSPTSGLIQSSKTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C290</accession>
    <name>A0A0D2C290_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237990.1">
        <property type="nucleotide sequence ID" value="XM_016379313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C290"/>
    <dbReference type="STRING" id="91928.A0A0D2C290"/>
    <dbReference type="GeneID" id="27332052"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04969"/>
    <dbReference type="HOGENOM" id="CLU_032690_3_0_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="186"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="298" mass="33273" checksum="3512EE4E059C0EC4" modified="2015-04-29" version="1">MAGVESLDFESHIDLRQIGPDTYTNVHPPWLFHITQTVPGPLMMAEAAAAAYKTVAEGFRIDSLQVNFMLAPKADQPLVYKVQRLSQGRRFVARLIHIEQDGKICVTITASFVSGASWTGRAMTHAESMKTVDRVTDITLDDFEDDHSPIGPFMKFQRLPHLPQEASDPTATIAPVVAKVDPPMKAPAGSPLHMLGIIYLSDYHVMDCPLRIHDISLGLFPLNDHTRTRQPTMMKISTSLNHTIHFHVHEGFRADELVYVETTTPWARDGRAVIHSRIFSHKGLLIATCVQEVSPILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6P9</accession>
    <name>A0A0D2C6P9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239475.1">
        <property type="nucleotide sequence ID" value="XM_016377905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6P9"/>
    <dbReference type="GeneID" id="27330636"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03553"/>
    <dbReference type="HOGENOM" id="CLU_1377986_0_0_1"/>
    <dbReference type="OrthoDB" id="4117656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="205" mass="22714" checksum="43140330C787E6A5" modified="2015-04-29" version="1">MKRTAERPTDRSSKRSSIHDEHEWIIRGYRPDLANAPQSPDEDPLGEIAYHRAFTRISAQTPGRVPNPSFFPNSPTALQFMKWKDQILFSPKPAGDRTPTQKPTPVSQAPTTLPGNLPSPGYSEDPPKAYRSLSEDQARTGDSGSSTQGAVIKTQPRSPPPPVRLRIDQTRPQPHHQPAPMTNILPPIMEPRINAAPPGPDKVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C7F9</accession>
    <name>A0A0D2C7F9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Msb2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239695.1">
        <property type="nucleotide sequence ID" value="XM_016374419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C7F9"/>
    <dbReference type="STRING" id="91928.A0A0D2C7F9"/>
    <dbReference type="GeneID" id="27327134"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00051"/>
    <dbReference type="HOGENOM" id="CLU_008998_1_0_1"/>
    <dbReference type="OrthoDB" id="3366093at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250430" description="Msb2" evidence="3">
        <location>
            <begin position="19"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="69797" checksum="ECC8F0432755F376" modified="2015-04-29" version="1">MKISSITVFSAILAGALAQGVPASDPRRTDLKPRYYFPRVVKREVLGLNSTTSSDSTSTSTSSGGEDALSDAFSGLNSIISSDSTSSVLASTTADSATTAPGPAITGTGPVSFPASTTDSSDSTASATSSDPTITSSSSASGITLGLGSIITTSTDSATATSTDSTLESASSILSLASSLESVASTAASSDQASISSALSSAASVASSIASDITSTATSDSSDSSTTPTGTPTDGGVSTTPSTTATDGPTIGTGSTTPTTTPTTTTDGGISTTPTTPPPDSTTPPPDSSSTTPPPDSTTPPPTDNNNSTTPITSTPPPTDVSTTPLPTTTPSSEPGNSTTTPDVVPTTTPSETTPTETPTLAPTSTPIVNTTSIPPLTTSVPLTNTLKPTGTDSATALTPESSILSATFVTPTTKSSSSSAAVIPTSLPGFIQPPGGANTAPANTTLIQIGFDYGLNYAFVVSSQTAIQQIFSYLPPGLGHGMDQDASDVVMQYLQPYNTLDSLDYITTLAMAYIPSDHVNTLSVNLLNPNSELYNNPNPSIATLMSMIDSSIPLLPGSAMQSGGTPINSANGAASTTDSNGSNGAAPGSSDSGGSGSVRPSSVGIAVGAVAGAAVYGAAMFLVARRYKKKKSGHQRSSSVQSGQGRGGEQSNLMVAGGRGSYGTRFGGRTSQNSDRSGSNRSGRTYISPPVMAENSLGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8G9</accession>
    <name>A0A0D2C8G9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aminomethyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_00424</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240065.1">
        <property type="nucleotide sequence ID" value="XM_016374789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C8G9"/>
    <dbReference type="STRING" id="91928.A0A0D2C8G9"/>
    <dbReference type="GeneID" id="27327507"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00424"/>
    <dbReference type="HOGENOM" id="CLU_007884_10_0_1"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="9">
        <location>
            <begin position="94"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="10">
        <location>
            <begin position="414"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW19849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="502" mass="54421" checksum="5D3A79D070B37AF7" modified="2015-04-29" version="1">MPPPRALRQLQTAVSQAGRNIPRRSLRELSTLLTRPTSSPPSPASGPAPASQHLNVPSGARSPLSNVSRHCVTSRPAARFASSSSSTPLKHTPLYTLHESLGAKMVPYANFAMPVEYPDQSHRDSHLWTRSHASLFDVSHMVQHKLSGELAEEFLMTITPTAINEIKKHHSSLSVLLNKSGGIVDDTVITRIGKDSFYFVTNAGCRDTDLPFIQAEMDAFLKSKSAVSPSNNASDKITWHILDHHALLALQGPEAVSVLQALVFNDPEDETLDTSLDTLYFGTSRWLQLTLPESGMNTPSLLISRTGYTGEDGFEISIPPESGDATELATSIAKALTADSSKVRWAGLGARDSLRLEAGMCLYGHDLNDRITPPEAALGWVVGKSRRAESPTPPFNGHEVINKQLASPKTMAERRVGFTLEKGPAAREGAEVVDLENGNAVIGHITSGCPSPSLDGQNIAMGYIKNGFHKKGTKVGIKIRKNVKKAEVAKMPFVENKFYRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8P9</accession>
    <name>A0A0D2C8P9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OsmC-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240135.1">
        <property type="nucleotide sequence ID" value="XM_016374859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C8P9"/>
    <dbReference type="GeneID" id="27327577"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00494"/>
    <dbReference type="HOGENOM" id="CLU_100936_0_0_1"/>
    <dbReference type="OrthoDB" id="4139202at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052924">
        <property type="entry name" value="OsmC/Ohr_hydroprdx_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368:SF1">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="22222" checksum="3A7BF9AF8CE6CBB1" modified="2015-04-29" version="1">MADAVIAAANTLRAKQKPLKDKYRSDPSSALVTLSSSGDLDPTSTSLTCSLSAGQAARKVAGLHKAAGGEGFDATGELCSGDMLLESLVACFGVTVRAVATSLGIPINRGAVTVEGDLDFRGTMGIKDPDGNAVPVGFKDIRLIVQLDVDDEHKSKVDKLIEISERYCVVLHTIRNGVNVATRLEAALDAGTGNDSRTRGADIPASEEVLKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CBK4</accession>
    <name>A0A0D2CBK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241120.1">
        <property type="nucleotide sequence ID" value="XM_016375844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CBK4"/>
    <dbReference type="STRING" id="91928.A0A0D2CBK4"/>
    <dbReference type="GeneID" id="27328566"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01483"/>
    <dbReference type="HOGENOM" id="CLU_048904_1_1_1"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41735" checksum="BEC9ED03F377D5B3" modified="2015-04-29" version="1">MPADSLLDICIRACAKRRAFLPSVGDLPYELVRPILAKIESPEHLHQIEQASPQIVGEDAELWLNFIKRDIPDWHLKPHQPANPKNWYKVYRKLQADNQRSRAQTEEDLKAAFANIQSEKERNTTIIAKRQHLPLQTPSRKAVIHWNYISGKTGSKGAHKMTLMEKIRKETRNARISKMKRPTHELQKRATTVKTAPLAFVEDVKRKAEAARPLPPPQSPPTRGAAATTTPTRMSARPTAPRTSRPPMHAPKPKVQPLHQSYDLTADREARLRALKLGGPRPTPPTPASAPTVQQRAPGGGGLTANFLEDSDDEDDRRVQQPRRGLKANHDDRRPPSTNAVADRPPQGQTLKRKQPPSMFMSTSKRVARPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CC56</accession>
    <name>A0A0D2CC56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="13">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 13">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_01628</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241265.1">
        <property type="nucleotide sequence ID" value="XM_016375989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CC56"/>
    <dbReference type="STRING" id="91928.A0A0D2CC56"/>
    <dbReference type="GeneID" id="27328711"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01628"/>
    <dbReference type="HOGENOM" id="CLU_076902_2_1_1"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="25"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW21049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="103" mass="11616" checksum="E9FE4D0CD15F9E19" modified="2015-04-29" version="1">MADASKIHEYEVSLLEAHELSTGPLSILMTATRTHTQVLISCRNNRKLLARVKAFDRHCNMVLENVKEMWTEKGKGGSKGVNKDRFISKMFLRGDSVILVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCI6</accession>
    <name>A0A0D2CCI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241430.1">
        <property type="nucleotide sequence ID" value="XM_016376154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCI6"/>
    <dbReference type="STRING" id="91928.A0A0D2CCI6"/>
    <dbReference type="GeneID" id="27328877"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01794"/>
    <dbReference type="HOGENOM" id="CLU_471747_0_0_1"/>
    <dbReference type="OrthoDB" id="3734019at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="474"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="563" mass="62306" checksum="87B7B686CD29C7AA" modified="2015-04-29" version="1">MPSIRALSRRFTTGDIDNSDERPLTPPPPYVSDDEEICHAKDSKENPSDGLERDLSSLDIKFDSIPDLSLTNPAASRRDDSGPSTSSSGLSKRQMAKNYFLDFCYFPNDYDQRLAKYPDTQLKKQEAVKTRICYSSMCSIISGTAFAVPSHGASAGICVWAARRWYVAAKKLKFIKAELVNRGIELRPFLHRDWIIPASVAITCLAVGMGVDFGLAGAVPLGHAEHTLSGGGQIQPDSGTATQGLQHAGNVTVAHAADPALQTGTGSHIQSALHLQHGAEPAGALEWHQSLHEKIQSAAQNWGSGFRDQIESLFGSTHHAISSGFTPDQTYEGAAAWIAGAESAQLVEKQIMALLSMQVVQQVCERLDYESILPRYNHNIKCNSLPWATDIICSRCETNVSKGKFYHCLECRKPKDNQACTTTPTTLCIRCYESGRTCPGDDTHNFYAFPRAKFASYSQDTPYQKHQPRGQAPTGQATCSDCHARIDKGAFYHCSKCKGGTFDLCDECFELGEHCLDNGHVLVKFYAWKYIRHVDKTRKALWRCANERCVRPDRKNEFFFSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y4A3</accession>
    <name>A0A0D1Y4A3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230002.1">
        <property type="nucleotide sequence ID" value="XM_016386194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y4A3"/>
    <dbReference type="STRING" id="91928.A0A0D1Y4A3"/>
    <dbReference type="GeneID" id="27338969"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11886"/>
    <dbReference type="HOGENOM" id="CLU_007957_0_0_1"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="3">
        <location>
            <begin position="499"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="735"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="925"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW09786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="955" mass="103804" checksum="5DFB42C71DF94CF5" modified="2015-04-29" version="1">MTSGTPDSSFKLSGSSKKSIFERQKAEAEAKKAREKAETAAVLEDFVKSFEDDGNPNTFTTKRGGFGGGLPSSTFGPGPGKRHFTSSGLKSGPGSLGPAPSLPKSGPGSLGPSPSYGRKRHYDDYSGGRERDQDRGRDRDRRDRMFSYGDRDRDRGRDNTIDPAFSGEEDESKDVEEMKAAAKPTLHLSSLPPGTSTAVIKGLFAASPLNVDNVRILPKASGSLHERNSLSAIVTLAAETPATDIDTVISHLQNQYLGFGFNLSISRHLSSAALSGSHLLNAPPTNINNLPFGARPIPQHTSLSRAPPPNQGPGRFAPPASYTSSTPYGSRPNVPPTQVTVQIPNDLKQIRLINKTIEALLTYGPEFEALLMSRPEIQRDEQWAWLWKSGSTGGVYYRWRLWEILTNAKSRKRRQRAGFVTRAQGDTIFEGQSVWVPPEETLKFEYTTKVEEFVSDEDYNSSDEEDAEESTLARRYHDHQKVGGNAPENATDTDGTGYLNPLAKTKLVHLLSRLPDSNAKLRRGDVARITGFAIEHAGAGADEVAALITLNVVKPFCHTVTRPDTLSSGPASNDGYDDQNPDDNIPSLNPAPSADAVPITGGGGGGTTASGAPGEAELSKTGDDVGVQTSKVQDMTPSSLVGLYVISDILSSSASSGVRHAWRYRSLFETQLRVQGVFPTLGRAARDLNWGKLKADKWRRSVQSVFSLWEGWCVFPSAAHEHFVQGFLNPPLTAKEEEQQRRQQEAERVEKDRAEKAEKDRATKWKSVSVGVGVDDGGGGRDRDGDIDMDMDTAMAKGTTSMDGRPMDDTDEDSDNDNDGIVVVQPDEDLDGVPMLDSSDDEENIVVDQQLQKEGEEEGKDTVMHDHDHDQGQELSEARDTPRAETGTGSKNANANANANANAREQQQQQLNPQGKAKGVLPHNPTATSFPQLPQTSQTGRRVRPRAADFDDMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y560</accession>
    <name>A0A0D1Y560_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230262.1">
        <property type="nucleotide sequence ID" value="XM_016386130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y560"/>
    <dbReference type="GeneID" id="27338905"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11822"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF5">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
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            <begin position="48"/>
            <end position="459"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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    <sequence length="490" mass="53648" checksum="5F024E74C85BD15B" modified="2015-04-29" version="1">MSSDEKPMSELPIHIEKGAKLEPDSVEVTDQGNLAIEKALNRKYDFRILPCLFLLYFFSFMDRASIGNASIAGLNVDLKLRGQSYSVALALFFVCYMIVDIPAGLLFKIIGPRAFLCISIFCFGTCTICLGFVKNASQLYAIRCLLGLFEGGLTPCISIYMGMFYSPTNIQRRLAFYYCAAPLSGAVGGLLASGLGKINVGSYRAWPWIFFVEGTISILVGALCFFILPNMPGQSRFLTEEEREVARVRSGKISNTVDVNHEKEKFSWKAVKQGFQDWNAVLLAIISVGTYCNVYAYSLFSPAIIKGFGYSTIRSQLLSVPPYVFGAICVFATSFASDHLRVRGPFVMGPCCVEVIGWIIQMTCNGVGVRYFGLFLIAGSIYPAINSTSSWLIGNLQPHYVRATGISFAVAMGTIGGIISTFTYANAKGDVANGVELAMAVLVIALTGLLMWINRAENKLRARGGRDYRLNQGQSAEQLGSRHPAYVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y5H7</accession>
    <name>A0A0D1Y5H7_9EURO</name>
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                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
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    </dbReference>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000053328"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7G8</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
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                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="27337238"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10155"/>
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    <dbReference type="OrthoDB" id="10440602at2759"/>
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    </dbReference>
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        <location>
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            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
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        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
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        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="166" mass="17889" checksum="07A2EB466E8B4420" modified="2015-04-29" version="1">MALRVHLVLLSVLFFAITTTVFSAVVPVVPATSDDTDQASLNRLLNPPPTVDSLQCKASTQRMRCYGGPLVTIQVCASQCSCEGGRISCSRFSHCDDSSMDTFCGSLCSCGLAPGVKSGSGVKKDIISHRYSTTRKSYPDDDDDLENDDELPVTGRGKRVASYLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8K7</accession>
    <name>A0A0D1Y8K7_9EURO</name>
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                <person name="de Hoog S."/>
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                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
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                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="27337714"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10631"/>
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    <dbReference type="OrthoDB" id="5416037at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
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    </dbReference>
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        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="250"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="480" mass="54253" checksum="ED4CC227E5004EFE" modified="2015-04-29" version="1">MFVSVRDQGHRRRSHTFGVSKAARSSKLSLLSAITTSSHGSNDSARTITQESYRKSTSVSGKRRRSSHTRGPLKSRDRKASTVKTKPGQPEKEKTMSRESVDVFAFLVQDEEQNPTSLQDEVARPIQDKYQTHEESDTESVSRSQHSDSGISMGESIICRPHTDSLVEGHLPSLPEESQETAESRLQLANGSTDERRLRFQWPAVPRATHKPYYNKAGSRTPSPENIRRHMPFVREDVPPPPKEASLSGYDLVAHKLMHEELPPVFRRFQKSNYRMLLQLQDEISEMEDDLAALDLKDSRRRLKVDGSTSPASRRLSWEWTQSDLQSHRLEVLGRLYIKLEQYYQALLSAQKVQRLSASPTQPDLERFRTWMREKNPLSAPESKFLDHEDDLICLTSNSTSSSATGSNIGFVPACIVSTSLLPLFCFKIVTGVLSRLIILVVLLAVELGSLEKLDRSKVGQHQQWIFACFGVLLLVALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8S1</accession>
    <name>A0A0D1Y8S1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231602.1">
        <property type="nucleotide sequence ID" value="XM_016385000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y8S1"/>
    <dbReference type="STRING" id="91928.A0A0D1Y8S1"/>
    <dbReference type="GeneID" id="27337769"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10686"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF6">
        <property type="entry name" value="VIC POTASSIUM ION CHANNEL, BETA SUBUNIT (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="342" mass="38557" checksum="61678C71CD483C30" modified="2015-04-29" version="1">MEYRYLGHTGLQVSVLSLGSWITYGGHVDEEEAFRAFKTAYDAGINFFDTAENYSAGRAEIVLGKAIKKFGWKQNDLVISTKVYFGLNNSAHPERPLNNNGLSRKHILEGFALSLQRLDLPYVDIVYAHRPDRNTPIEEIVRAFNYLINTGKVFYWGTSEWSATEIADAWGVASRLGLIGPVVEQPQYNLLVRTKVEEEFRWLYEKYGLGLTVFSPLKQGILTGKYNGQDSPPPDSRLSQAKDKYTVAYSKTFGNETWKLELEQVEKLKPIAKKLDSSLAQLSLAWVLKNPNVSSVITGASRPEQIQENLQAVELSSRLTPEILKDIDQTLGNSFDGPPRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y9B2</accession>
    <name>A0A0D1Y9B2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_10857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231772.1">
        <property type="nucleotide sequence ID" value="XM_016385170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y9B2"/>
    <dbReference type="STRING" id="91928.A0A0D1Y9B2"/>
    <dbReference type="GeneID" id="27337940"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10857"/>
    <dbReference type="HOGENOM" id="CLU_004390_0_0_1"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="9">
        <location>
            <begin position="42"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="799"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="896"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="961"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="922"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="971"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="990"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1053"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1184" mass="135572" checksum="3A69C2410F4A0431" modified="2015-04-29" version="1">MNENMEEGNPFTKAQTVHPEVRAYVYSLVNALGGSSTDDDGRYVLGDDALACLRDLKRWLKFYDEKNNRLDVARCLAEAHLVGGDLIPILASWPEDGKDNKLKARVALACLELLVPLTWPLETGGEMTSNHHRHTPYLQQAQVLYKAGVLGCDTSSILRQVVRIGLPSIAIARADRTARDEGILKLMLYFFRNLAVIQQLPNLPSQGLDSEVSRSATIEAFRDQDVFALLLTICSNMGEDFNLQDVIVLDIIFNLIKGVDPKRLWMTEQERKGHGITELGAALALEDSQTRDAKRHQWSRHGRFGTMIWVKREDQKMSAVSGQDNLKNDQQAFFNMDKSKKWNKPQQKRKDIEHTIHDFDHTARLTDSAAEKLRNFVEEFLDSGFNPFFTHLRKAIEREAERLAEVNYRQFFYSVAWFLDAERNRRAREKKENKLDKVRTDFEDESYSLVAAVLNQETFIMLNRFMQLSLDNKEAQDLNASMRCFTQILLTVQEMAQSPIEEDQEIADNIQNRIFYEETTHDRIVRILREYKDQGFGYLDACTELSHVFLRMLERYSKENVDLQIRSRRRAKKRHKEVQRQAAQPGADPSAEDEESENEDIADVVQVAKERKFDFHRFAAKFSTQASVNTFVALTAFYKDLGTEQLKRAHRFFYRVAFKQDMGILLYRVDIIALFYKMMNGPDGLESKHPMFKEWSEFTKQLFRKMFKKIDQRPELIIELLFSKISSTLHYLEFGQEKQTISATRAPPELEIRPAQGRGVQEQIGIVVTVLLKDGKDELIQWTKHVLGKAHDERHAWEAEAEARKGAPTEVAEEQPGPPSEKDNIGQPPGITIQAASEDIKTAMFKNARLRLLMTLVGFERLGDEDVLGATWIVPSSVSSHDLAESKKAIQHYEQTPWQAENAHEDAEDMIRRKPKARKSNEDEEDAPRDAFIDDSEGDEEFLFPDNPRKKRSKDILKELKARRKRKRGSDDDDNVDELDEEAAARRRAAREAAARERRLKIKSEAYIRDSDDESDAERDRLFFEREEELRKKTAEDHIRKQAAYVNEQSTKSKGKGKRKGTKPALPQTQETTQESDDDILMGGRDDEPNETASSQPQGRSDTEAESEEETPFSSQSSATVRDVRHQKSVLREMSQPRVASRGASGKNGGGGLDDGSDGDEDIVPIVRQQRVRGGFVIDSDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDF6</accession>
    <name>A0A0D1YDF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233212.1">
        <property type="nucleotide sequence ID" value="XM_016382509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDF6"/>
    <dbReference type="STRING" id="91928.A0A0D1YDF6"/>
    <dbReference type="GeneID" id="27335266"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08183"/>
    <dbReference type="HOGENOM" id="CLU_002639_5_1_1"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="203"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="704" mass="78690" checksum="601BDDC347AF8C2C" modified="2015-04-29" version="1">MLCGHCCQLVQQIELVKPGAQVFREATTEEFEESLNRNCYLCTRLRIQLGDAKWKHLFSHLSRQNSIAFDKSLSAADGFSLVRLGCKLTPFDGHDRDGTTIGGKSYSYGYLQVTIAPWARSSPHLPVQIGVRNATCTSDAKVLDLVRHWLETCLCSSLHTTCPGQNRQTSFHPTRLIDIGSGHGDRGHWRLMNPKAERLSAPYITLSHRWGNETLKLNRDTQESMIRGLPILDLPGAYQNAIRVARRLGIRYLWIDSICIRQDTPEDIQHEAEGMAEIFGNALCNISALSGRQDGLFCSRNDEVVSSDSVVIQSQDYGLSGSYIINDLQLWRGELVHTPLTTRGWVLQEELLAPRTVYFGARQVLWDCPGFRACETYPTMQPKRPLSMSMDIDKHCYFLHDEELGPIASVLEAAQSSMDHASVSSSPHDDRSVLFQVWTSLVAHYSLRNLTFPDDKLLAIAGISKLFGRIMRDRFLAGLWHNHFLDGLLWYIRPKTRTYAPLRYRAPSWSWASKDGYVMHAEAASNSWSVARTLSVECTTADGSAFGVVTSAVLHLQAPCLELCVDRSGKWTTSQAPGLLVRLDSTEDVSARGNAIGAIIRTSAYRIVDAETDAARKVVLAVHGIILTECVDSVTGHATGTFRRVGYFAVEDRRRSTLAPNWLPRGCNLFRDIGGSASASSMQQEEQVFPFDEQRQFLSDFNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJL9</accession>
    <name>A0A0D1YJL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="9" type="ORF">PV08_05221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235392.1">
        <property type="nucleotide sequence ID" value="XM_016379565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJL9"/>
    <dbReference type="STRING" id="91928.A0A0D1YJL9"/>
    <dbReference type="GeneID" id="27332304"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05221"/>
    <dbReference type="HOGENOM" id="CLU_006033_4_0_1"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW15176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="235" mass="26307" checksum="B20072FDFBA9E2BC" modified="2015-04-29" version="1">MTDERNDHLVQSDDPDHPANLIPTLCKQFYTLGWVTGTGGGTSIRKDEHVFIAPSGVQKELMKPENIFVLSYPTPKYPPSARQYIRKPLDLKPSACTPLFLAAFERGAGCCIHTHSQWAVLVTLLVEKMSGPAACFEISNIEQIKGIPKGPGKGMLGFHDTMKIPIIENTPFEEDLTEHLEKAMEQYPDAYAVLVRRHGIYVWGDNVAKAKTQCESLDYLFQLAVEMHKLGLPWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YK67</accession>
    <name>A0A0D1YK67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235592.1">
        <property type="nucleotide sequence ID" value="XM_016379765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YK67"/>
    <dbReference type="GeneID" id="27332505"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05422"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="87"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="563"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW15376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="652" mass="72250" checksum="368B522BECAA6BE6" modified="2015-04-29" version="1">MNYTDPEAAARPRQSVEEYALADLPLLADELARNHDELDELDAFDGETGDDVPAARRFQRPSKNRSPSEPSLTVREAIRAYPAAIFWSFAVSMCIIMEGYDAILIVNFFAFPQFQRKYGEFVGVTEQTQTGYQVAPAWMAAVGNASGFGAFLGTFLNGYLVSIFGQKRVLLGALVLLSCFIFLTFFAPNIQTLLVGQLLCGFPWAIFATTAPAYSSEILPMSLRVFGTSWVNMCFIIGQLISAGVLRACLERDDEWAFRIPFSVQWIWPAFLIPLLCFAPESPWHLVRQNRLAEAEASLRRLQRASYSRVDVTQTLADIIHTNRLEEKLSVGTSYWDCFRGFELRRTEIACVCFAGQVLSGLSFAYNASYFFEQVGLSASTSYSLNIVGTALALLGTLVNWFYFTPRMGRRTLYLLGMSVMAGELFLIGALNAWTHRGFVAVTQAGLTLVWTFTYQVSVGQLGWSFPAEVGSTRLRQKTVCLARNAYYVVAVASGVLQPYFLNPEALNLRGYAGFIWGSTAVLTWLWAYYRLPETRDRTYEQLDVLFAKRVSARDFARTRVVVDDDDDDDDGGGGGGGVTMAGQFRGAAESPSGGRTPPSVEGAFSSQRNSSGTDVERHSAGTRRRSSRDGEVVVGPEEEEEEVQLLGRGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YP19</accession>
    <name>A0A0D1YP19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237112.1">
        <property type="nucleotide sequence ID" value="XM_016378435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YP19"/>
    <dbReference type="GeneID" id="27331169"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04086"/>
    <dbReference type="HOGENOM" id="CLU_028818_2_0_1"/>
    <dbReference type="OrthoDB" id="5086080at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF7">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="49069" checksum="C75CEF839736930A" modified="2015-04-29" version="1">MACDDGTPAPECDSRHGTGSRRGDSNLSRRERKRASDRMSQQATRARTKAYIAHLESTTQRLTEALAGEGTAALSKRLSEQHDQIETLKKALARIAMVANAANNGCNANDSESFLRAEVESRSLRDTILSNRCETILPSTEASVVDSKCGCFPSDTLAPANAFAQQESLLQMYSLPDLLCGNQDRDYFSILNQALETIENNHARHLFSGPEVDDDTCIRAILHGWDAARSRNPFDVGWQLLELLDEGLFCRSGSVERMAILRVMRAMLMTKINPRLTPERRPPAYMNPRLAYRRPSQFLLLMKYSHLQLQVSHVRLIDYFTWPEVRDYLIISGITYAPESLAAQFAADIGLKWPYTLRDTCTYRPSTGRYTFSHEFTAVCDDLESWYMKSPSIPSHLPISPDKFTTGSEEDWCEPLCEQWNMPLKDFPETSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRK2</accession>
    <name>A0A0D1YRK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238097.1">
        <property type="nucleotide sequence ID" value="XM_016379420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRK2"/>
    <dbReference type="GeneID" id="27332159"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05076"/>
    <dbReference type="HOGENOM" id="CLU_2941715_0_0_1"/>
    <dbReference type="OrthoDB" id="4154892at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="60" mass="6584" checksum="848236C1C66C7406" modified="2015-04-29" version="1">MPDLYQLFAGFAGLVTIASLWNLWGGELFPAERDPKGGPFVYPSVFQAPYVPGPVHAYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YS37</accession>
    <name>A0A0D1YS37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02308</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238237.1">
        <property type="nucleotide sequence ID" value="XM_016376667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YS37"/>
    <dbReference type="STRING" id="91928.A0A0D1YS37"/>
    <dbReference type="GeneID" id="27329391"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02308"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="460" mass="51571" checksum="FA52334C6A4D13BE" modified="2015-04-29" version="1">MSSFNYGFDVQAMAAAQAMNSFDAQFGIYAKKTHKWKLQPYFLSLLNSCHAPAQIAGVYVGSVISNRYGRRMCVFVMSIYALFSSAIIFSSHTKAQILAGRTIHYCYLGMELAVVPTTLAELSPPRFRSSMVGLYWLSIKLGGLIISVIANRTSQVNTNWAWRIPFSLFFIVPTIVASLIWFLPESPRWLVLRDRHDEAAKSLRRLRKPETSDAQLMAELDELETAVAQQPHKGKFMEVFRGTHLRRTMIACMVNFFQQASGQSFSSQYGTLFVKGLGGVDPFTINMVNNAMNVIGIVICLLLSDRFGRRPMIHISGVLQVGALLTMGALGVHAHPRLSERRGIVAMLLVFSFGYSVGWAPLTYLIAAEVPSPQLREHTLRLAYTIKLVTEWTVSFTYPYLEDDQYAGLGSKLGFIYGSFAALAVICGYFFVPETRDLALEEIDWQFSNDVPTRKIRSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YS71</accession>
    <name>A0A0D1YS71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PV08_02363</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238292.1">
        <property type="nucleotide sequence ID" value="XM_016376722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YS71"/>
    <dbReference type="STRING" id="91928.A0A0D1YS71"/>
    <dbReference type="GeneID" id="27329446"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02363"/>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="17">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="18">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KIW18076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="451" mass="50251" checksum="6B58BF6426E016C0" modified="2015-04-29" version="1">MREVISLNVGQAGCQIANSCWELYCLEHGIQPDGYLTEERKAADPDQGFSTFFSETGNGKYVPRTIYCDLEPNVVDEVRTGAYRSLFHPEQMITGKEDASNNYARGHYTVGKELIDQVLDKVRRVADNCSGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKCKLEFCVYPAPQVATSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGIERPNLENLNRLIAQVVSSITASLRFDGSLNVDLAEFQTNLVPYPRIHFPLVAYAPVISAAKAQHEANSVQEISMSCFEPNNQMVKCDPRNGKYMATCLLYRGDVVPNDVHQAVATLKTKRTIQFVDWCPTGFKIGICYQPPQMVPNGDLAKVNRAVCMLSNTTAIAEAWSALSHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVASDSIEEGEGSELLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YTP5</accession>
    <name>A0A0D1YTP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238827.1">
        <property type="nucleotide sequence ID" value="XM_016377257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YTP5"/>
    <dbReference type="STRING" id="91928.A0A0D1YTP5"/>
    <dbReference type="GeneID" id="27329983"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02900"/>
    <dbReference type="HOGENOM" id="CLU_860620_0_0_1"/>
    <dbReference type="OrthoDB" id="4161676at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="323" mass="31898" checksum="EEF1538EEBDB40E8" modified="2015-04-29" version="1">MEAAKSAISNLMGYNKDEDATTGTGTTAGTTAHTTHHAGDNTFGKGSLGQVSGSTYVLLSAPAHHATTTGTNAETDYGTNTSATTGTYTDEGTGATSGASAGSSTGPSAGHSTGHSTGHSTGHSTGPSSTRAATGASSAGSSTDTDHGHKSGVHLHNPLHHHKSHDKSDESLESSRSHAQSPSQGRDPAVVGDDDPARKLTGTAAPGSHSAVFGLTPSGEKVTDTRPGTGIVKPASELGKSKSGNEHSSTSAGAGDTSSRAPAGGKELSEQMHNPRDQGPKGLERTDPVTSLGASDSDKPGAGGVGLHQGTGDVRPGERGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUI3</accession>
    <name>A0A0D1YUI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239132.1">
        <property type="nucleotide sequence ID" value="XM_016377562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUI3"/>
    <dbReference type="GeneID" id="27330288"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03205"/>
    <dbReference type="HOGENOM" id="CLU_470120_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="580" mass="61944" checksum="C3EE4736F47D2C15" modified="2015-04-29" version="1">MSSTASRRVAQGTADDVLVPARVVVDVELVPGRVVVDVELVPAPVVVDVELAPAPVVVDVELVPAPVVVVLEAEVGFVGHVGSLRRTLTGPPKLSHTPLSSPAARAAVTCSGVRERPTSWLLPINTEAMFEFSERSVGTRERRSLTVHSRPPRRGQLYVATEFAVINAEFKQTLMLRLQIGVADVVDELVDEDVLVTVVRVVDPGAMVLDELDVVLADDEVVAVTVVRLDDGAALLLDGLDVVLADDEDVPVTVVRLELVPLEVLVITDEVLLVGGAFGHVGSRIVTLTGPPRASQIPFNSPALIAAETAAGAILSPRTSLSPIKTVATSGLQIGLADVVVLVPPDDVRELDVELKVVLLARVDDGELEGELDEDDEDEDDEDEDENDEDENDEDENDEDENDEEEDAAEDADIEDVAELDEELPDDAELADDTELENDAEVDDEAELAGDTVLADVSEVVYELAVDEAMLVEEPIPVDEEVSVLIGKTVLVDELVVEDDNSVDVEDARVVLDGLSVVSRDVVVSPEDVVVPPEDVVVSPEDEVEENPAVDDTVVEVAGTSLVLDTELSELETLEADAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUZ1</accession>
    <name>A0A0D1YUZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239302.1">
        <property type="nucleotide sequence ID" value="XM_016377732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUZ1"/>
    <dbReference type="STRING" id="91928.A0A0D1YUZ1"/>
    <dbReference type="GeneID" id="27330461"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03378"/>
    <dbReference type="HOGENOM" id="CLU_021766_1_0_1"/>
    <dbReference type="OrthoDB" id="4104179at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF2">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002247283" description="Glycosyl hydrolase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="62148" checksum="A68B4C47B98A48A4" modified="2015-04-29" version="1">MRPSLVVFAFLEIFRLVEPRSVERYTYAAVVDSPVETPGQIGLVADEREDVPTKSWKNDLPSTLQDMLDALEVMQDTYFDLFSGTWPSAIDWTSAVMGTQVSATLGSIVSSLDASATSTCADMLVMQNIIDRYFAQTSVFYFGENAFGLRNQAYDDMLWVVLGWLENLKFAEMYSLKHWDFLRHNNGWHGLQFIPMAAHRARIFYDLAASGWDESLCGGGMIWSPYLTPYKNAITNELFAAASIGMYLYFPGDNNTSPYVAQGSEGSAQPHDPVYLENAIKSYKWLMESQMRSPAGMYQDGFHVTGWHRYPNGTINPGTGKCDELNRMVYTYNQGVVLSASRGLWLATGARSYLDDGHALVESVIRATGWPNNDSAWSGLGRSGVLEEFCDHGGYCSQNGQTFKGIFFHHLSEFCRPVWAQEESFLAARIASGDFDRDVYDYHLARCAAYDKWVAHNAQAALATRNTNGHFGMWWTFGPPDEEAMEVIRETTVLVDDADDHLNPKPQDWSDQPVTTADCNDRGRGRTVETQSGGLAVLRAKWNWDVYFREIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVN0</accession>
    <name>A0A0D1YVN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239562.1">
        <property type="nucleotide sequence ID" value="XM_016377992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVN0"/>
    <dbReference type="GeneID" id="27330724"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03641"/>
    <dbReference type="HOGENOM" id="CLU_1161147_0_0_1"/>
    <dbReference type="OrthoDB" id="10621487at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="239" mass="26152" checksum="220343E1258089FF" modified="2015-04-29" version="1">MVDQGSTPNIKKRRTNAAQPPLGQRQGQNPASRQRQQDGGISQQDTLGGAQAVSLPTQPRPVQHPLGGTFAGPAGRWRQYTPREVDAYHGLLALRYGPMVEFPRSENPNLTVNPSLTMSSLPGLVVGSDNTSENQPAGSKDNRTVAVANMRPPPAGAANHQPQTGSLKRTQRDSDNETQDSGNGRKRPRPPPKRYSCYLCEYTALGVTYVSRHLQNKHDVASDQIDQVRIRASEVQCLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZW0</accession>
    <name>A0A0D1YZW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_01434</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241072.1">
        <property type="nucleotide sequence ID" value="XM_016375796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZW0"/>
    <dbReference type="STRING" id="91928.A0A0D1YZW0"/>
    <dbReference type="GeneID" id="27328517"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01434"/>
    <dbReference type="HOGENOM" id="CLU_008110_2_1_1"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW20856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="626" mass="70234" checksum="60D1271516F41A6E" modified="2015-04-29" version="1">MSSPANAHRPRKKRKQPPLTRSATITDIVRFTAEDNVVAPEFPLVAFLWPARGTTSQWILLPLILMIVGLFRWSVGLWGHSGYQQPPMHGDFEAQRHWMEITTHLPVSQWYFYDLQYWGLDYPPLTAYHSWLCGKIGSLFNREWFALDASRGIESQDLKVFMRATVIASEYLIYVPALIIFIRRFSRAQGVGTTASSIALVAILMQPATILIDHGHFQYNTVMLGFVVASLSSIYASRPLWACIFFVAALGFKQMALYYSPVIFAYLLGSCFTPSIRPGRLVLIALITILAFAVLFAPLLLGSLYDSYYTTIPSGSLPAPPLLADHKVPTDPNTPLEMILLQLGQVVHRMFPFARGLFEDKVANFWCFANTFYKLRKLEGVVELSRLSAVATLASILGPMLVIGAIPKKSLLPYALAASAWGFFLFSFQVHEKSVLLPLLPMTLLLGGKQGLSKEYRAWIGWANMLGMWTMYPLLKRDGLRTPYVVVTLLWAYLLGLPPTSVNAYHDPDRPNVPGRPLAPDELRAPTKILHFQTYIVMAFWHLLAAFASPPEDKPDLWVVVNSCIGAVAFGICYLWCFWKLICESGLIDAYFAETQESAETRASSSPSPPSPSRERRSATPQKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZC25</accession>
    <name>A0A0D1ZC25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230748.1">
        <property type="nucleotide sequence ID" value="XM_016385804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZC25"/>
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    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="509" mass="57562" checksum="D1CF3123A9DA68F0" modified="2015-04-29" version="1">MGKPRLIILIRHAQSEGNRDKRIHQTTPDHKVGLTSEGHTQALEAGQKLRALLRNDDTLHFFISPYRRTRETTEGILNGLCSNDPVPSPFQRSHIKVYEEPRLREQDFGNFQPGTDEVERLWRERAEYGHFFYRIPNGESGADVYDRVSSFNGSLWRRFSEDNMASVAILVTHGLCSRVFLMAWYHYSVEFFEDLRNINHCEFLVMKLAPNGRYVLQNNLRRWSDLRRERAARKSISQSQSPVTVESIPVRRWTSNRAVAHDPSGATLGHGTNSQLPRPSRKNTADMFRDDREDVEDKNQHQHQSQQGQRRDSVSRARTRSQSQSKNQSQSQSRVRSTSSTLRTSLNNLSLETSTTKKAGLRAYLGRDGGGSRSGAASPFGTDDESDGTPQSEVKVKGGFGKDHHDHSQGHNRSNSHGQSGHVQQTPKFSSSSLARALRGDFDLDGNGGGHVRSFDDRTAVADPLGDQPSDAEVEEADLEMGTKRLEELEMEQIIEEERNERSHRGSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZE12</accession>
    <name>A0A0D1ZE12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231468.1">
        <property type="nucleotide sequence ID" value="XM_016384866.1"/>
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    <dbReference type="GeneID" id="27337635"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10552"/>
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    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055449">
        <property type="entry name" value="Iec3-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032742">
        <property type="entry name" value="Iec3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24244">
        <property type="entry name" value="Iec3-like_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14612">
        <property type="entry name" value="Ino80_Iec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit 3 N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="INO80 complex subunit 3-like middle region" evidence="4">
        <location>
            <begin position="154"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="345" mass="38448" checksum="FD6F3E579C6F5BF8" modified="2015-04-29" version="1">MSASGAPDTPPAPEQASPPDGTAASRKSYRRKYRKIMVTFEEKMRESTSLFKEEQRIQDISQRLAEQTDQLLQLLTELNACPQVPPRLRYDLESSPNHDPAAAPGLDVKTEDEGHLALRKARSQLQTGEIDLTRYREVEHSLLKSEAFAPKRSYVKLVAETHLPRPREKVKSGSEAAAGGFLSVGQEELYLDSLDAFLEGTATHPRSHAANGLGTRNAEKTTEREREMQLRNPVSVYNWLRKHQPQVFLQDNEAAAEKAARPAGSRSSARKSASKDVVKLEQDLYDDDGIASEVASSARGKRKRDDDGGYRPKGGNSRGTKRRKDPKEDSSGRNKRVKKLSMDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZEX0</accession>
    <name>A0A0D1ZEX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit SPC34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein SPC34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_10797</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231713.1">
        <property type="nucleotide sequence ID" value="XM_016385111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZEX0"/>
    <dbReference type="GeneID" id="27337880"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10797"/>
    <dbReference type="HOGENOM" id="CLU_064328_0_0_1"/>
    <dbReference type="OrthoDB" id="10016597at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013966">
        <property type="entry name" value="Spc34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08657">
        <property type="entry name" value="DASH_Spc34"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW11497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="234" mass="26373" checksum="19B17FCDA79C6DCC" modified="2015-04-29" version="1">MALLANHLEQITLSSKSIAGLEFLPPKIFTNAILGDYEITTLIRDTESHERALFTLDPHAVGRSRRSNATQQHANSAGLNGLFPTVQSTRQSVVTRLLGDDILQEIRQSSKKRDGVNVEVLLQGAERLCEVYAVGGAPEKIRALRNRYEDVATSISTLEEKVSQQQALLERRNRSFEVEHEELESADPHTDYSMPLTEQDFQNEEDEIKELEARKKALEYRVSGMERDLGGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZGK7</accession>
    <name>A0A0D1ZGK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232323.1">
        <property type="nucleotide sequence ID" value="XM_016383700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZGK7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZGK7"/>
    <dbReference type="GeneID" id="27336464"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09381"/>
    <dbReference type="HOGENOM" id="CLU_022730_3_0_1"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF129">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="323"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="599" mass="62120" checksum="1736025369E7D376" modified="2015-04-29" version="1">MGDAGPCSPTLLTGPAGLPSANPTKAFWQTSHPNPVAKHRSTPGLPATADIVVIGTGISGTFATHEILTTAAAAAGQALNVVVLEARTTCSAATGRNGGHCQPLVHAERPAIIDFEMRNYAHIRDLVKLHDVPCDFRQIPGVLGFWNKTYFDEAKAALQGSLVTAEHRKLVEVVEAPEELQNLRLTGGVVGAIVQTVAASLSPYKLMIWLWGEMIKEYERSEGGGGRWEGGGGWGGGGEWQGGRGGRGGWGGGGDWRGGGEWRGGRGGGGGSWEGGGGFGGGGEWDDGEGGGGRWGGGGGGGGQWRGGGEWGGETSKVTLNLQTETPVASIQEVQGGHGWTVKTSRGEVHAKQVILATNAYTSHLMPEFEALISPVQAQMSALLPPQGSPFRERLIPMSYGMMGVEGQDRVMSDYLVQNPILDEDAGGVVGRGGHLMFGGGRAQARGNGVGVSDDDYVDPDAEAYLRSLPEHLNLEAEEEAGGAPQTTTGTGTSKSGLLDIAASWTGIIGSSADGHPWVGGVPGRDGLFVAAGYSGHGMTNAGLCGRHVAQLALKSLKGEDWKALQAHGVELAEQGKGGVPREYVITQERIDAARGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHP2</accession>
    <name>A0A0D1ZHP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thymocyte nuclear protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_09704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232643.1">
        <property type="nucleotide sequence ID" value="XM_016384020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHP2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZHP2"/>
    <dbReference type="GeneID" id="27336787"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09704"/>
    <dbReference type="HOGENOM" id="CLU_041799_0_0_1"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000003">
        <property type="entry name" value="Thymocyte nuclear protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="6">
        <location>
            <begin position="203"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW12427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="434" mass="46553" checksum="A5CB36BEF8C6C8C5" modified="2015-04-29" version="1">MAPKKRKAASRASTPAKKVRIGETSDIPDISPVGRPRRTSVGVPQYNFTRPKSSVAKQTPSQARTSEVDVKPKRRGRPPKSSPPVASPEPVTTENIAGPEQKKRGRPAKGATHASTNGTQLEQKNKPTSASLTAAAPKTSLVKKQGARVGRPRGPKTGGTPKAASPSSSESEEVLDGTPVVGDAVLATATVEEDIQDVDQDVQYWLMKAEPESRIEKGVDVKFSIDDLAAKTEPEGWDGVRNAVARNNMRAMRKGDLAFFYHSNCPNPGIAGVMRIVAEHTTDQSAFDPAHPYYDPKSDEAKPKWELVHVEFVKKFDKFISLKDLKTFSQQGGVLANMQMLKQSRLSVSSVAPAEWRFILGLAGEKPSLGHVQGEAKDGYESDVDGEGEETAAEGVGNKTFDTSLEGDMQPDLSSPVNGANGAAHEHDVITTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZMM9</accession>
    <name>A0A0D1ZMM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234278.1">
        <property type="nucleotide sequence ID" value="XM_016381176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZMM9"/>
    <dbReference type="GeneID" id="27333926"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06843"/>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="70857" checksum="DD8B386E1F71B2A1" modified="2015-04-29" version="1">MAPSTVANGYGGMHLPADGSTTDAELSRRVERPQVVNNPAPDDVRILEQLYGTRKKMRVVMLGAGMSGLNFFKFAEEKLKNVEIVCYEKNRDVGGTWYENRYPGCACDIPSVAYQFPWRPVPWSKYYSQSGEIWEYIKMVERENNFIEKYVKLQHRIVSLSWGEDDDGATGPGAPRWTVRVQDVVSGREFDDHADFVVDGGGVLNKWKWPDNIPGLQDFKGTLLHSAQYDERIDLTGKRVALIGAGSSAVQILPNIYDQVDRVYTWVRTKIWITAGFAQNFAGKDGANFAYNEEQRKMFENEDEYLAYRKMIEGELNQRFGFIINGTSAQKAAREFSEKEMRTKLKDRPELLEKIMPDDFFVGCRRPTPGNGYLECLAGPKTTAYTTQLGQITEKGFIDPDGNEQEVDVIICATGFDTSYKPRFPLVVNGVNKSEQWKDNPHPHVPSYLSLAYAGVPNYILFGGAYCPSAHGSFFPIIAAYVNYTIQVIEKMQIENIRSIQPKEKVVEHFMKHADTFLKRTAWTGPCSSWFKGGKKDGKPAIYPGSRLHFLRLLEKPRWEDFDVEYDQEEDMWSFMGNGFHVCEQDGSDITWYLGELKQEVDQDKVRRVMDGTKGIEIGIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQK5</accession>
    <name>A0A0D1ZQK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PEP-CTERM system TPR-repeat lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235268.1">
        <property type="nucleotide sequence ID" value="XM_016382166.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1ZQK5"/>
    <dbReference type="GeneID" id="27334922"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07839"/>
    <dbReference type="HOGENOM" id="CLU_001688_2_0_1"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="708"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="965"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1402" mass="155932" checksum="E5EA18A3BC7237D2" modified="2015-04-29" version="1">MASKVLLKAIKASLDSGHFEKAAAQAEDVLSQDNKNHTALLFLGFAREKLNDLDAAEKAIRKAADLKPQDPQAYKGLITLFEKQGSSKVDAYHDVAFKLADIYAQQEDRAQCQNVIDKYELFAKKHGTRAQYRRALELILPTSSLYSALEGRVMQPSLTYQRILESAEAEEKEWINTQIGERRTRLGARIDQVTKQVKAEAIDKFHVEDIYAALIDWTRDDDARHDLEQKLFKRMYDNLHVVPEQKKPQQRDKVLTMANGMVIVKQPFNLAWRVALEWVDAEELEDWDVHIFREYVGFFPEDGLSKILGGFLNSDFSPFPQPPVDPSEESEKPETLNGADLLILLNEGLEDCPDSLLAHRIMAYVYLRFEDWEGTVNVARKAQSLVKDAQHLFALELQNTLDGVNLILAKALIEYQSPRYHPEAKSLFEEILKRKPKLTAALLGIGLIFEEDEDYPQAVQFLQQASERDPHNVRVKLEFAWCRAQNGEIEDGLRDLQHILSDIEEERHQDLLVKSIVLYRIAWCQWHLNPSAKARKDKSGPYKYLISSVKANPSYAPAYTLLGTYFQDYGKSKQRARVALQKAFELSTSELDAAHRLAKAFADDAEWDLVELVAQRVVASGKAKPAPGSKKRAYSWPFAALGVVQMNKQQYFQAIVSFQAALRINATDYYSWVGLGESYHNAGRHIAATRAFAKAQSLDHGLPADETWFAEYMLANVQREMGLYDEAILAYKAVLNLKPDEFGVLIALLQTLSESACAKVGLGMFGEAVKLAASAIEVATDIAQRNTDSFNLWKSVGDACSVLGQVKLYGDSANLRSIISLLRLSLGNDLEILADLDKVDLDATTTNDHQTQSSLSDSFLHTAILAHKRAVHASSTDQHAQAVAWYNLGWAEFETYTISAAPTELRGKKHRRFLKAAIKCFKRAIELEASNSEFWNALGVVTLNLSPQVSQHAFVRSLHLNDHSARTWTNLGVLYIVHGDNQLANEAFTRAQSEDPEYADAWIGQGLLALLFGSMGEARGLFTHAFDIADSSRLPAQRHYAISAFDYLLKDPSRSQEVDHLLQPLFAMRQYHVQQPSDLITSHLMALLAERAGDCESTSKVLQDICDAVEAEFEKSESTEYLVKFAQAKADLSRAQLAGGDFSGAVSSAETALDLSGEADDFGPAYSELRQKWRLSAQVTSGLAHSHLGNTEQSIKMFQEALREGKDEPDIVCMLAQVLWAKGGEAEKEAAQSQLFNVVENNPKHVQAVCLLAVMGLLDDDEAVLEAVEEELKAVRLTDDVGVLDKIRVSKVLAGVVGCKQKAQQDGEEAQVATIADALDGIMLAPGQPQGWLELSQAVQDEDAGVYAGEMAVLNASRQVPPGGKLEADDLALAYQGTGQVDDVLRAKMLAPWRTEMDVTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZU11</accession>
    <name>A0A0D1ZU11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236503.1">
        <property type="nucleotide sequence ID" value="XM_016380676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZU11"/>
    <dbReference type="STRING" id="91928.A0A0D1ZU11"/>
    <dbReference type="GeneID" id="27333421"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06338"/>
    <dbReference type="HOGENOM" id="CLU_006926_5_1_1"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="164"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="534" mass="60436" checksum="F4CC87910C382766" modified="2015-04-29" version="1">MHPGLEISIETEVSRPPALTESKRPIKIRLPPYNHSIYLIQCAEAAIGHDQHYFRRRQLRARARQMYEDPESTRSKDHGWLCYWLAALALGELYKDNGGTTGPDSSLETGHVSSDATKEPPGAEYYHQSVAFLQQVAENPDLQYIETLCLLTMYAFSMDKVNTAYMYNGIALRAALSLGLHRNLLDFPSERSNLSVAELEYQRRVFWTVYYQDLLTTATTGRPWGILDDEITIEYADSSRLVGDSLQDFFDSDESNAHLEVMRLRGQAYSSLYGYAGTAINPYSHISLFNFDLGNLLSQQHLDKMDEFHQGLIAWQKDLLPKLKLIRNWDGSLINLNRVNASLHLIYHQTILVLLRPALVNIHNDRFDARSKGLASVIDLFPGSKSILQAFYTACLESARETATILEWLHYHGILSIHAYFDASYAFTAAIVLYMTQQMHAFAYPGLDPFSFTDDDQSALDTILRILHFQSSAGNIPARDFEKRLRLLENNLSALETELANHVCLDELNFEIDSLNPAMPALAGHTEAPLYVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZUB2</accession>
    <name>A0A0D1ZUB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236588.1">
        <property type="nucleotide sequence ID" value="XM_016380761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZUB2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZUB2"/>
    <dbReference type="GeneID" id="27333506"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06423"/>
    <dbReference type="HOGENOM" id="CLU_012153_6_3_1"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04733">
        <property type="entry name" value="OYE_like_2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF5">
        <property type="entry name" value="NADH:FLAVIN OXIDOREDUCTASE_NADH OXIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="101"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="438" mass="48377" checksum="9CB66E488E08B505" modified="2015-04-29" version="1">MSRRVASETSDPSLLAQPLHFEFSGKVAPNRFMKASMTERLSSWDPENFEARGIPGAEIHRVYERWGAGGLGHILTGNIMLEYDQLEAAGNLIIPPGAPFEGDRFDGFRKLATLAKKHGSLITGQVCHPGREVDERIQKHPVSASDIQLEGKVLGMQFAKPHSASPQEIKTIVEEFTHSAIYLAKAGFDGIELHAAHGYLLGQFLSLTTNRRTDEYGGSLRNRARIILEIAAAIRSRLGSGSGFILGIKVNSVEFQSGGFTVEEARELCAMLENAEFDFVELSGGTYQSMAFHHQRESTKKREAFFMEFADMIVPTLTKTKTYITGGFKTVGGMTKALETVDGVGLARALCQEFDLARNILEGRVTGVIQPLVDQDDFFLTNVIAGSQMRQVAKGQEPMDMSKPENVPTFMQALAEWSRKNEEDKLTMSLYGYVDLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZ00</accession>
    <name>A0A0D1ZZ00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_05082</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238103.1">
        <property type="nucleotide sequence ID" value="XM_016379426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZ00"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZ00"/>
    <dbReference type="GeneID" id="27332165"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05082"/>
    <dbReference type="HOGENOM" id="CLU_049413_3_4_1"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="250" mass="27995" checksum="A192A576082EEC3A" modified="2015-04-29" version="1">MTAKAPYILAPTADDSSSERPATLIFLHGYGDDAEGLPLGLAQQFQFYKRMPYLKWILPNADHNHEAMARAWYIPKSLPNVMKPPIPGHEEDDEASPDDEPGILKSADIIDELVEQELKSGTPAERILVGGFSQGCAVSLVWSLVGRFRHDVGGLVCLSGYLPLKDRIKALQQDRPAASPEGIDKRKWFYVHGTKDMLIPKRLYLQGKEELSRLVGQERIEEHLYEGMGHSMNAAELRDMLGFFERVIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZT2</accession>
    <name>A0A0D1ZZT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238463.1">
        <property type="nucleotide sequence ID" value="XM_016376893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZT2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZT2"/>
    <dbReference type="GeneID" id="27329618"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02535"/>
    <dbReference type="HOGENOM" id="CLU_002865_5_1_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="372"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="18"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="479"/>
            <end position="480"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="60062" checksum="BEF0CA55CEE9EBA4" modified="2015-04-29" version="1">MDENIPLIADVVVAGGGTTGLIVAARLAKADPHLSIVVLESGINIRDNPSIVNPAVYISNILPGSKTATFYKSKCSESLAGRELVIPTGGCLGGGSAINFMVYSRPQMIDFDDWRSEGWSGKDMVPFLKTYESFQDEAPEIDKSLHGYGGEFSISPGTNAQTIFQEDYFQACRQIGLPQVPDVQDLKTSNAVGRWNMWIDQKTGRRQDVAHQLLYPLLDTHETVLRVFTQVSVVRVLFNEQKRAVGVEYVRVGPGAPAISSVVRATKLVVLAGGTFGTPGRLTLESALEQKEAQPSRYVLGWNGLDCVGKIRPSTGDEDLLGPELRELWESDYRLRPTRPLMLMSSLAAFVGDHSGVPTGQHFSLGPYTPYPYSRGSIHITGQTVLDPPDFECGFLNHPADVQKLVWGYKKQREIARRMTHYRGALEIGHPVFPEKSKAGFDFVDNQDRERGIYAPIEYSAEDDQAIELFIRQNVSTAWHSMGTCAMKNKGEGGVLDPRLNVFGVQGLKVVDLSICPSNVSANTYATALAVGHKAASIIAEELGVPYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZW1</accession>
    <name>A0A0D1ZZW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238488.1">
        <property type="nucleotide sequence ID" value="XM_016376918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZW1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZW1"/>
    <dbReference type="GeneID" id="27329643"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02560"/>
    <dbReference type="HOGENOM" id="CLU_074897_1_0_1"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25931" checksum="3C76567F4F3E6627" modified="2015-04-29" version="1">MDWFWRSKSPKAHEASEPNSSSLSQASASIAAPALPSVAEPVKSALSREEQANQEFLELVRELQAQTEPTSEKSLEGTKSARSVHTTPVEVDISPDSLYPTEISCRSSFDYAMFCQSFGGQFVNIYRYGSFRSCSNHWDDFWLCMRTRNWDAKDRAAAIQDHYRKKAMKWRTGPSSEDVWDVRTEPVKDAFQGNLDELEAAIAAWKKANPTALDPWERPQPPAFNSQTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A396</accession>
    <name>A0A0D2A396_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239588.1">
        <property type="nucleotide sequence ID" value="XM_016378018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A396"/>
    <dbReference type="STRING" id="91928.A0A0D2A396"/>
    <dbReference type="GeneID" id="27330750"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03667"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60571" checksum="A72FFA9EDF219977" modified="2015-04-29" version="1">MALYVSQASAALAVAIVLYVLLFVGRRGRNFPDGPPTLPIIGNLHQLPKHKVYLQFTEWAKQYGGMYTLKLGPTTAVVLSDRRIVKQVLDKRSAISSERPANEISQHIITEGDHLLWMNNTPAWRLMRKLIHQDLTEKMCENDHHKIQQAESVQMLHDMLESPDDWMSHLKRFSNSVITSIVYGIRSPSIDSTYITRLNELLEKWARINEFGATPPVDIFPFLKLIPERFLGNWVTRATVVHDEMHSLYNKLRETVEKRREAVGPMSTVVDRLLDQQEKTGLTTHQITLLSGVTTKGGSDTSASVLSSFMQAMVTNPHVVQKAQAEIDAVIGDDRVPNWSDYGDLPYVAAIVKESHRWRPVAPLSVPHALSEDEWVDGKLIPKGATIFLNVWGLHHDEAKFPNHDTFDPDHYKGRTLLASEYANSADYENRDHYGYGNGRRLCPGIHLADRNLFHAISKILWAFNIEKATDSKTGKPIEPDTSMVTGYREGLTACVHEFPIKLTVRSQAKKQTIIKEHDDAKANVFPEYEKTAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4U9</accession>
    <name>A0A0D2A4U9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_00427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240068.1">
        <property type="nucleotide sequence ID" value="XM_016374792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4U9"/>
    <dbReference type="STRING" id="91928.A0A0D2A4U9"/>
    <dbReference type="GeneID" id="27327510"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00427"/>
    <dbReference type="HOGENOM" id="CLU_098404_2_0_1"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW19852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="181" mass="20101" checksum="50F58268FE17E69C" modified="2015-04-29" version="1">MEHTQPKWVIELNNGPPPKSKIASSLPDPPGYSSRSTSGKQKAQVSARKAPTPEETETLKLKKAWEIALGPAKQIPMQAIMGYMSGNSLQIFSIMMVWMLFKNPIQAISQTNMAFSKLESEGTRSQMLGVKAVYVLMQCLLLGLGIYKVNSMGLLPTTTSDWLAWEFERQPLERAYFAFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8W2</accession>
    <name>A0A0D2A8W2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241438.1">
        <property type="nucleotide sequence ID" value="XM_016376162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8W2"/>
    <dbReference type="STRING" id="91928.A0A0D2A8W2"/>
    <dbReference type="GeneID" id="27328885"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01802"/>
    <dbReference type="HOGENOM" id="CLU_051118_2_0_1"/>
    <dbReference type="OrthoDB" id="3533814at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="4"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="292" mass="33822" checksum="AB827369B980372F" modified="2015-04-29" version="1">MEGYDTLSAAFSCYPEFAIYRRFSIHRHRNLMLLEAELLQKEEQLLTFIQDDRESDDPKRKSFAVNFDALLNDSSPLGSRQRELMKEFRELQKEYDEGLLRARLIANLPPVRKTNLRVLEDEVLRDTPDKNLFFKNAVEAFPWTQEDMEYDMTSLLDTEGGTDILTRWLTWIITEPYHKLFGKKEVISDRFPKNWRPLRPIKLSRYRDEHIARLVTVVATILAPILPTVGAFCLYFINDELLRLCIIVLLSFLFSSAVAVVGMPRRIDSFIATATFSAVLIVFVSPNASCVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A9Q7</accession>
    <name>A0A0D2A9Q7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241693.1">
        <property type="nucleotide sequence ID" value="XM_016376417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A9Q7"/>
    <dbReference type="STRING" id="91928.A0A0D2A9Q7"/>
    <dbReference type="GeneID" id="27329140"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02057"/>
    <dbReference type="HOGENOM" id="CLU_006937_8_1_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="574" mass="63975" checksum="5A0C0FF9E98F36AA" modified="2015-04-29" version="1">MANSLDVLIVGAGFGGIYQLYRLRQQGLKAKVIEMASDVGGTWYHNRYPGAMSDTESFVYRYSWDKEDLLTYPWSHYYVKQPEVLKYLEHVVERHDLRRDMQFNTELLSADWDEASKTWRVELSTGETVHPRYLVTALGLLSKANYPDIPGLDTFKGVKCHTAAWPRDLHLSGKRVGVIGCGSTGVQVITDIAPKVSSLISFQRHPQYSVPSGDGPVAPGYRERVNENYDEIFKQVKNSIVGFGFVESTVPFSAVPSPEEREAIFERLWNQGNGFKFMFDGFCDIATNKEANEAACAFIRKKIAQIVRDPEKARKLQPHDYYARRPLCDGGYFERFNLPHVDVVQLQETPITRVTPTGIETTAGSYDLDVIVFATGFDAIEGNYNRIRIRGRGGLTLRDYWAPNGPTAYLGVSVPNFPNLLMITGPQGPFTNLPPAIEAHVDMISGLIARTEESRQKQQQQTTGGGAGGEAPVIESLPEAEQGWLDECERMAEGSLFKETASWIFGQNVPGKKYALRFYFGGLKSYYETMQKVIDNDYAGFKPISVPADTPKQAASSSGVPGEVQGQEEISAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATZ3</accession>
    <name>A0A0D2ATZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Catalase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_11721</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230161.1">
        <property type="nucleotide sequence ID" value="XM_016386029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATZ3"/>
    <dbReference type="STRING" id="91928.A0A0D2ATZ3"/>
    <dbReference type="GeneID" id="27338804"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11721"/>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_1"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="10">
        <location>
            <begin position="9"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW09945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="519" mass="58073" checksum="61DEC9B4E446ED4D" modified="2015-04-29" version="1">MASSQPYYTLAEGVPLPRNGTVQQLSTGSGGGHVLLTSTQLIENLAHFSRERIPERTVHAKASAARGYYEVTDDVSDITDADFLTGIGKKCEVLMRISTVGPERGSADTVRDFRGFAVKFKTNEGNQDFVFNNQPVFFIRDPVKFPSVNRSHKRHPTTNASNADMFWDFHVNNQESIHALMFLFGDRGLPSSVRHVNGYSGNTYMFTKDDGASYVYVRVTLKTNQGIHYYTNAEGAKIAGTEPDKHILDLQDAIKAGDFPSWDVYVQVIRPEDVEKAPVNIFDMTKVWPKKLYPLRKMGRVTLDTNPKNWFAEVEQAAFSPSNMVPGIGPSPDPMLQARMFAYPDAARYRLGVNYQFLPTNAAISKVYCPIERDGLMNFTLNYGGDPNYIGTQLKPNRFTVRTSSQPKSEVEALSTRPKTKTADQVQVALPVSAFTEVTEKDFEQPIALWKIMGTQDGAQDRFINNLAGHVSGVEAKWIRQAVYEMFSKVDKELGKKVEEVTEAKIAGDHAHIHKTAWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AU31</accession>
    <name>A0A0D2AU31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_11215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230469.1">
        <property type="nucleotide sequence ID" value="XM_016385525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AU31"/>
    <dbReference type="STRING" id="91928.A0A0D2AU31"/>
    <dbReference type="GeneID" id="27338298"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11215"/>
    <dbReference type="HOGENOM" id="CLU_012062_9_0_1"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001113">
        <property type="entry name" value="RNP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="36"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="212"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW10253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="328" mass="34843" checksum="9783ACFF6750BB06" modified="2015-04-29" version="1">MSSAVDNLAENLKNASIEDTSAANNEAVLASAAEGRRLYIGNLAYATTEAELKQFFAGYDVESTSIPVNPRTNRPVGYAFVDLKTAEEAEKAIENLSGKDILERKVSVQLARKPDQTSGEGATSGAEGGERKRSAGRGRGGRGRGRGGRAPRSARSTENAGAEATDLAENPLPLTDVTADANKGESTDPKQTRAPRPPKQRGPPEDGIPSTTKVMVANLPYDLSEEKLKELFAAYEPSSAKIALRPIPRFMVKKLQARGEPRKGRGFGFVTLASEEMQKKAVDEMNGKQIEGREIAVKVAIDSPGKEDGAEITGENGTNGTTEEVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUC8</accession>
    <name>A0A0D2AUC8_9EURO</name>
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            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016386154.1"/>
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    <dbReference type="STRING" id="91928.A0A0D2AUC8"/>
    <dbReference type="GeneID" id="27338929"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11846"/>
    <dbReference type="HOGENOM" id="CLU_1156401_0_0_1"/>
    <dbReference type="OrthoDB" id="4482343at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF13489">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27319" checksum="E86E3676767454FD" modified="2015-04-29" version="1">MDVVCATVSSCSSASLKLSSGFPSPIDDGAQDDHLARHLLFQEVLQNRTFCAPVNLENGKVLDLYTRTGKLAVDIADENPSCSVTGVDESLMHDEWVPSNLVFEIADIENEDWTWKDRFRLVIYRGPGGFTKNLSRLLRRCFESLEDQGYVEFQLLALDPQSHREGPRSEESKIRDLHRRLSEGLSATGRELNVHHELPRQLQKIGFHNIEHKKFAVPLGKWPKDPRLVILFIEENRKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVS6</accession>
    <name>A0A0D2AVS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_10147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016384462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVS6"/>
    <dbReference type="GeneID" id="27337230"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10147"/>
    <dbReference type="HOGENOM" id="CLU_060128_0_0_1"/>
    <dbReference type="OrthoDB" id="2334691at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35839" checksum="A0FBBFC8DA369373" modified="2015-04-29" version="1">MSSLISTTLIPPKFLQPAFLTGSIPFRVSRAHPSVSYTLYIPPHAYNPDPSRSASDDPVYSLPRLPLVVSVHGTGRRAEGCRDSFKEFADKHHVAILAPLFPAGITSAIDLDSYKLLRTAQNFNSDQILLSIIDDEIAAVWPGISTSTFSLVGFSGGGQFALRMLYIHPERLQAVSVGAPGRPTFLDTSESWPNGIRDVQDVFGPGAKVDIDAIRAVPAIQLLVGSEDDFIHGGEEFMAFIAQFRASLSTSKGGSSHRSVAADPQLSPMREGRLTGLTKLRDSWKELGIVSRFEIVPGVAHESQKVISTVLDFLLPQIETFKNQLQEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVV7</accession>
    <name>A0A0D2AVV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C4-dicarboxylate transporter/malic acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230771.1">
        <property type="nucleotide sequence ID" value="XM_016385827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVV7"/>
    <dbReference type="STRING" id="91928.A0A0D2AVV7"/>
    <dbReference type="GeneID" id="27338602"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11519"/>
    <dbReference type="HOGENOM" id="CLU_030057_2_0_1"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47125" checksum="DB1704E8775324FD" modified="2015-04-29" version="1">MIHIVTKNRGSEASNSNDDMVNIKDNPNVPTSEQGFARLKHLTWAWFTLPMATGGLALLVAPDNQPHSFTGLITIGKIIFIFDIVVFSLIVAGITYRFSRWRGTLKSSLAHPTESLFFGTSFLSLASIISCLAHYAIPSCGEWLVTAYRVLFWTYFAITYVIAVCAYLVLFTNPRLRIQDMTPAWDLPMFPFMLCGTIASAGIPTQPARYAMPMLFGGLTAQGLGMLVSMGMYASYVRRMIMYGLPSPASRPAMFIAVGPPSFTALAITELARHYPAAAGYDYFGPDVYTVQIVQVLAVMVAVFVWSLSFWFFCLALVSCVAAKGRYHFHLNWWAFVFPNTGFTLATISIGRSLKSQAVQWVGSAMTICLCLTYLFVAYHHVRAVWRKEVLYLGKDEDNYHPEKMAKVESRGEDPERCGCVSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWR8</accession>
    <name>A0A0D2AWR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenical resistance protein ArsH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231359.1">
        <property type="nucleotide sequence ID" value="XM_016384757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AWR8"/>
    <dbReference type="STRING" id="91928.A0A0D2AWR8"/>
    <dbReference type="GeneID" id="27337526"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10443"/>
    <dbReference type="HOGENOM" id="CLU_055322_0_0_1"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014063">
        <property type="entry name" value="Arsenate-R_ArsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590:SF1">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="115"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="321" mass="36816" checksum="A8B51933443506EC" modified="2015-04-29" version="1">MKMAVDAEHQHPPFCAEVQNQRIPPIPSKPEQPLTNGDLNNTASVRITSKPERHPDFAYRFLSISADMDEPTIRSKYRPFLLPDTVQLQDWISRLELATVTELVYNDLRVTGERIKVLILYGSLRQREDNLSYSKLLAFEVARILWRLGCDVRVYNPQGSPVKDDDQHNHPKVQELRDLSRWSDGHFWVSPEQHGNLTAVFKNQIDWIPLSTGSVRPTQGRTLGLAMVSGGSQSFNTVNSLRVLGRWMRMFTIPNQSSVPQAYTLFTDKDEDEGGSRLMPGGNRDRLFDCAEEFVKYTVIMRPHFALFSDRFSEREPLVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AX34</accession>
    <name>A0A0D2AX34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_10274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231191.1">
        <property type="nucleotide sequence ID" value="XM_016384589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AX34"/>
    <dbReference type="STRING" id="91928.A0A0D2AX34"/>
    <dbReference type="GeneID" id="27337357"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10274"/>
    <dbReference type="HOGENOM" id="CLU_767334_0_0_1"/>
    <dbReference type="OrthoDB" id="4160919at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238739" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="37969" checksum="3B7E8FD68D43E6E1" modified="2015-04-29" version="1">MSTHTRMVLWALVLVLSISFSNASPSVPVATDPVVTTTTVTTVVPSLVTIYSVVPATGDPNLVSTITTTINGQETTVISSGGVVAGSSTSTIVSTLTVTTTEVVVSTIGYSTVFGPDPEPATTPASTPATVSNPTAPTTPIGVTPATSLSLGTSTTLPTGIVSSSGAGITNTASDIVQVTSSTSSSASTAAATAPGSSASPASSSSSSSSSSSSSSSSSSLSTGAKAGIGVGVVIGVIGIVIISFFLGQRYSRRRRDEANSRALAESDSPDQEKDVFLAGRPYEETNPYHTAGESTTGNNQFSTTTTTTATTEAGSPSPGMKFEDVSSPAMSSYRSHNDEISALPQVKDEDDMYVGVPSYMSGSKRWSMKEYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXV6</accession>
    <name>A0A0D2AXV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231496.1">
        <property type="nucleotide sequence ID" value="XM_016384894.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2AXV6"/>
    <dbReference type="GeneID" id="27337663"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10580"/>
    <dbReference type="HOGENOM" id="CLU_001976_0_0_1"/>
    <dbReference type="OrthoDB" id="5408934at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056416">
        <property type="entry name" value="DH_2_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056222">
        <property type="entry name" value="PH_23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056223">
        <property type="entry name" value="PH_24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36721:SF15">
        <property type="entry name" value="EN_SPM-LIKE TRANSPOSON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36721">
        <property type="entry name" value="PROLINE-RICH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24340">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24344">
        <property type="entry name" value="PH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24345">
        <property type="entry name" value="PH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBL homology" evidence="2">
        <location>
            <begin position="537"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="748"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1367"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1415"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1585"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1674"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1591"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1674"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1698"/>
            <end position="1707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1821" mass="199646" checksum="0988EE55C75599E8" modified="2015-04-29" version="1">MRPAVPAKASHKVYSTQRTEVLGSPQSPNVASDRAFNNHDHGSVQDRIRQWQAQGAASAVDPDALSVRSTPRSECASFDSRPKSDYGDLDTPRLGRMKEKTEEQPRTERSSSAPRKRIISDGHWRAKRDAKDSKNPRVTARGRVETKRYDLSYTSNQEQQNGQPRPHRKYSFEKSPDLHQNSPANDGIRVIPNPSAQLNTSNQGSLAVPDAASYNQDESPRGLGIQPRLSRQFDATSDISADVNESRQRDRPQSKYVATLGRAPVAPSEGLRSKKAGLLGKTRDMFSKSDSTIPVSNRIPSIEAWLDEQPDPFMDEAPTDELPPVEMPAPLRRRTRKKKSSLDNTKVPDPNHIWDSVQSPDAPLSSEPRSTLEPENDRPRHSPRSDQDSTPKRRRRQIREKDDPDGSPTSLRRAGARVRRRRDTPDKRSISSFEGTKASQPENERLSDSQQILSAAESVGQAALFTKQHELPPLPPEEPDADDGPIPPQLATSSNPESRLKRRLTTHEDLMSVLSMPRARRSRRSARRARSKRMAEESASAHQILASLVSDEQRYSRELRTLVDGVIPVLLQSVLSKTDAAVAAGLFSSALNSQHDMSYTKPIIDMGIALERLKSLHGRIPLQTVESFLSWAQTAQKAYREYLQAWRLGFQDVVVNLAPLDNAPMDQDLTRDEVGDLVDNEGKKVDVAYLLKRPLLRVKALSRALVQIRDQSDRPLAAQVADSFTDLTAFARRRHQEEQARLEDEAAANIDATRTRDIRTMAPTANIAVDKTRRVKARDFFNLTLYHSSGQRMDCGIELIYRDNARGDAPGGDVLICEVDDTGKWLLFPPVQWGSISARRGEDEFDLVIMIRGRAGLGKEWQELLALKTDDKEAVTEWMSMLGSNPLPPRLNRAPSFAKRHQPPKDLSVHQALSEISSGSRTETQSISQGSEPSNVEVPIGEPSVSGARTEASRHVNTERITSERPSLRLNLGGGLASKPRPVQYQTQAPLASRHSVPSMLSSDRSTISDKSIKTVETASFHGPITTKADYVPEPSQVTRMADPLIPVRLPNDALRSPSQKDGIRESQAAERHEGRIYDSPFPGTNQVPRDLKQSLSSPVKNSSSNSPSRDTTPIVTAQGMQPQRPVYARAPSSTPSKDLPSVPRLRPQSQADIGPAGSPLTEPLKTGQFLPENKPKRGPMQDKSTTRSQIFTEDVPVPPPTAQVREGRPSPTIKSPALSPSPSATPRTMDKPQSQLRENHPPELKTTPASSEKAPRRRTSSPLKHEYAPSTSSDSSSDYDTESVSDSSETSEDFSTEQQDKATPLISINPTERRPSKQTYPPSSMPLAIRSHPPSSMQSTGTRTLAPSDSASQGPYRRVPSSNVVPADKKKRAAALICSWSDKGAWEMIHPDECSIVITPGLIEAFEMSAEHSNPGVSSLDKSLPGTTTPTQQPLVGFELTPLVMLRKGAALDIQIRSPPTPNSRIRTSSNIMFRSSNLQACEALYSMINWARCNNPTYIELERARPHQPSVTFNVNSSDQTRSRASSWFSFGSAKKSSYRASSAPTPASIDVSVESSGTMASAFSALRRFSAKPAFNINRSSVVRRDTGTTGPSLYSSSSGTRTGTGSGSSTPAPSQVGFVPGKDGPNVPATSADAANGGGMVNNMKIRLYMRKGQHWENMGGARLSVLPAPASVPAAEQDSSRSVSVAPSPPATPAHAHSRSPSTVEPGSARRGPRLPSSNHTPHRVHGNGREKRVLIVRNKAPDVVLLDAVLGESCFERIMQTGIAVKVWKEDEVIGHTGGVMMGRETVYMLQFASNKEAGWVFGLCGSYRYGFTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXW9</accession>
    <name>A0A0D2AXW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosylmethionine tRNA ribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_10809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231724.1">
        <property type="nucleotide sequence ID" value="XM_016385122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXW9"/>
    <dbReference type="GeneID" id="27337892"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10809"/>
    <dbReference type="HOGENOM" id="CLU_136716_0_0_1"/>
    <dbReference type="OrthoDB" id="2563170at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021660">
        <property type="entry name" value="DUF3253"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11625">
        <property type="entry name" value="DUF3253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12314" checksum="ED40AE96C7018403" modified="2015-04-29" version="1">MVEIDADSSAKGEEAPFDLSLVFSRHVARREHPKTLCPSEIARSLSRADLARLGVSEWRDLMPRLREMAFEARDKGEIQVLQKGEVVPPDLGMDKVKGPIRIRKAVLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZ30</accession>
    <name>A0A0D2AZ30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231946.1">
        <property type="nucleotide sequence ID" value="XM_016385344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZ30"/>
    <dbReference type="STRING" id="91928.A0A0D2AZ30"/>
    <dbReference type="GeneID" id="27338115"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11032"/>
    <dbReference type="HOGENOM" id="CLU_022944_0_0_1"/>
    <dbReference type="OrthoDB" id="3344043at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="587"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="723" mass="78327" checksum="B2AE8F7AA078DBD7" modified="2015-04-29" version="1">MESTLESPSRLPLLPEKSPTTPATSNDTDSLLRSPISPKAQKAFMKGAMTSLVWGACAPCIPIMIVTCMLLKPILSHRIKDSLVFVPTSDQATTGNEALDALKGIQSFQSSGGSKAYYLHHNEWTNPAVLHMIASWSAKILPFVTGTSMALVAFFAGHHFIWTTQNNSKKLPSPHQVSILIGLLNGGGTQPLIDTIKYRMHHDEHLVQPLPIAFWSLSFIVVMTFAIGAIDSWFGATTTALNIALVTPSANTSHSFGRSLISDCISESWQQHSCPSNAQATCAYPCSISTWNASSGQEREGVKNAQQAAQTLMFRSKNTTVLNTTLNGASYFFLGDVDGNAKLDFSATAVAVSTQCQMVTPNCTVRPDLGPGFTCGSYNAPSFSYSGAVGFAPSAVTSPSDMAMVGIQFFNDTEWNQPVGFGDNTTDLFAVKNPIYFLTWSKGFPPMNTHASDGFSAMRNGRYYQYDDTGDAVYILDCSTSIYDAEYYWVNGTVASIEIKALKSGYYGAALSAPFSTYTALAHLSLQDAAALAAYQTDPQNLTALYSSYFSRAAIGLTSGFSVAVANERESNRTNSYLATRVPLVPLYTLIALKAVYAAFALGLALLAVFLANPSQSQEAKERLTIHGLAAGFFEPKKQHERAVRNVQDLFEEHRDPEPSDDTKRIGMVRTQQGGWQWVTLARKTADTFGIPEMVNIAADEAAGRQDGIGRMAQGLRLVNEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZC2</accession>
    <name>A0A0D2AZC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_09088</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232031.1">
        <property type="nucleotide sequence ID" value="XM_016383408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZC2"/>
    <dbReference type="STRING" id="91928.A0A0D2AZC2"/>
    <dbReference type="GeneID" id="27336171"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09088"/>
    <dbReference type="HOGENOM" id="CLU_003041_26_2_1"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="181"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="408"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="461"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="760"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="461"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW11815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="841" mass="91346" checksum="E0BDA23CA1F4AC86" modified="2015-04-29" version="1">MADDGMFLNFTVGEPVSAQAQKFTGGSWRHRLKVKRWAQRGGGPRDSNDPNKVPLHPRRQTKEQAEDFGDSRPTKRRRDNDYTPGAAQGVGNVQKSYDPRHSKGPREVISSLFSYNPKSVSATGKEQEKVTEEEPTVPSNAPLVDGIDTFTSLGLSPTVAAHLLTKMNLKNPTAIQKAAISQMVKEDSDAFIQSETGSGKTLAYLLPIVQRIITMAESQKGAGHASQDPSVHRDSGLFAIILAPTRELCKQISVVLERLLGCAHYIVAGTVIGGEKKKSEKARLRKGLNILVATPGRLVDHLDNTKVLDVSTVRWLVLDEGDRLMDLGFEEDITKIVKTLDERKRTSSRLGLPSQRTTVLCSATLKMNVQKLGEISLKDAVLIKGESTDDDPDREDEGTGSAFLAPAQLKQSYLVTAAKLRLVTLTALLKRTFARKGSVMKAIIFVSCADSVEFHYKVLTRSSSENSSTTDNATSTTTSKPPTPPASTSSDSDSDGDSDTETKPKKNKTRSTKQTPKLPTIDPSADAISPSPILSTPANPITVYKLHGSLPQATRTAIVRHFGSTTAPSLLIATDVASRGLDLPNLDLVIEYDPAFSSDDHLHRIGRTARLGRDGRAVVFLLPGKEEGYVDILHKSYKPSSDADTSRNVTHQAAEDVLKKGFSPLSGILPTKKASQTSSSSTGKDAQSTAAAGNWDTIATNFQLEVERWILSAQHNKDLAKRAFQSHIRAYATHVAAERKYFDIKELHLGHLAKAFGLRDPPGRVNVVGQRGGAQSKKRGRPSETGGPSSGDGDNDGRRKQKAADIDEVDDTDDAARKMREKIRKNRALMMGKGADEFNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0C1</accession>
    <name>A0A0D2B0C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_09435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232376.1">
        <property type="nucleotide sequence ID" value="XM_016383753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0C1"/>
    <dbReference type="STRING" id="91928.A0A0D2B0C1"/>
    <dbReference type="GeneID" id="27336518"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09435"/>
    <dbReference type="HOGENOM" id="CLU_029507_2_2_1"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="171" mass="19293" checksum="4FB5B48D1295276C" modified="2015-04-29" version="1">MASATTFFDFTPKDKRDQEYPLAQHKGKVILAVNTASKCGFTPQFAGLESLWKKISEKYPDQFVIIGFPCNQFGGQDPGSNDQIQEFCQVNYGVTFPVLGKTNVNGDHAEPVFEWMKSEKPGLLGLKRVKWNFEKFLIGRDGKVVQRWGSMTKPDSIEKDIIHEIEKSKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B190</accession>
    <name>A0A0D2B190_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232899.1">
        <property type="nucleotide sequence ID" value="XM_016384276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B190"/>
    <dbReference type="GeneID" id="27337044"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09961"/>
    <dbReference type="HOGENOM" id="CLU_000960_25_2_1"/>
    <dbReference type="OrthoDB" id="2587356at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="566" mass="60346" checksum="5063543C1E4F45E5" modified="2015-04-29" version="1">MANPSKGTPTKSVEPEAFIAHEEKVSIEPSAHNDSGNDFQAYETRNIDMRTVLGLLALAITYECCLFSFVLPAVILLIINQDIGPSNNIAWVATSWTLASAVVMTVAGRCSDIFGRRNFFLFGNVLGVIGCTIACRAMNVSVLILGSSILGLSGGLQQLAFAAANEIVPKRNRGQTMAMMTLVSLPGSAFGAPIAYRIISVTSWRWTYYVALIVNGIALVLILVFYWPPNFLGLHPEGKSRRRQFSELDFMGLLLFGGGLTVFLVGIGFGGNPYPWTSAVVLCPTIIGFLSVFVGFPAWEVYSPDKITKLCPPRLMRNVRAVVVPLAVSFVSGMALISLGILWPQQIARLFTTVPKTIGWYGLANQGSATVGLMLAGQTFASLRRTRWQFIFIVTMMAVFLGLNATVNQYTPARAVVFVGLASAMIGATNCLSILIVQLGSCDEDIGVATGLVNSTRMVGGAVGVAIYSSLLANRIASTWARDIGRALLEAGLPASSLASFLSGLQLGDVTNVPGTTPSIIEAGVNAQKGVFVNAFRLIYCVTVAFGGLAIIGALFVANVDDKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1N0</accession>
    <name>A0A0D2B1N0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232736.1">
        <property type="nucleotide sequence ID" value="XM_016384113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1N0"/>
    <dbReference type="STRING" id="91928.A0A0D2B1N0"/>
    <dbReference type="GeneID" id="27336880"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09797"/>
    <dbReference type="HOGENOM" id="CLU_460807_0_0_1"/>
    <dbReference type="OrthoDB" id="3945550at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="66552" checksum="E62E7A84C8F1261F" modified="2015-04-29" version="1">MPSAGILGLEVEILADIFQIVNDASPRTTSAIAQVNKTFSFAVQLVRYRRETLHWDQDRSKFVDGFGRPLEQLLSPDRLRGLRHLTIAKSRAVEEFEDVTDSPATRLLIELLRASNNLKSLTYKTGNYPPSDLIRALQKKHPWADLKVYIDASKAPEPNETDPQDVCLAKSRLTELTMEIPASVRRPNHYQVQFEYMANAAKQLKSASLTMFNISAIRMRNWQAGSDGSTGSYGNTSLRHLSLDGWPLSGGTLEYWSQFVDLSRLETLSFTRGPLHTSYFTKAADMLRGLRSVNLNLSPFTCNEETADAAERYIATCSPLSTLSLWSWMGKVNLDTILTHHGSTLQDLQLHIREEEIIPEGPPQPLEVEKLRNIRMSCPKLSRFTVDVKRLSKDPVLDDYREIFDEIKLFNLEYLQIYFDSGLVYMVNLETRTDVDDDEEGDGDDSIGEDDDEDIDGLDVAQVAHEMPSPYGCGGLMDSNNLKTTDPTEHFPALHPPVSTEKISPFVHQTWKYVFGDRTMGDRVLDVKFGEWERKTPIGHYRFDGRPQKDLRVWCHAEPHPRDDKKGQSEVVLKCCQGHHLTKFSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2C0</accession>
    <name>A0A0D2B2C0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly protein COX19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233224.1">
        <property type="nucleotide sequence ID" value="XM_016382521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2C0"/>
    <dbReference type="STRING" id="91928.A0A0D2B2C0"/>
    <dbReference type="GeneID" id="27335278"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08195"/>
    <dbReference type="HOGENOM" id="CLU_141947_3_1_1"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11811" checksum="8D078AD570BFF7B8" modified="2015-04-29" version="1">MSGFGSPGGGAVSVKPTPPERGSFPLDHDAECKHLISSYLRCLRRQNPPGRNNEECRILAKGYLNCRMEKGLMAKDEWSNLGLTFDETAGDGKQNNLDEQTSPGSKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2N8</accession>
    <name>A0A0D2B2N8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233096.1">
        <property type="nucleotide sequence ID" value="XM_016382393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2N8"/>
    <dbReference type="STRING" id="91928.A0A0D2B2N8"/>
    <dbReference type="GeneID" id="27335150"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08067"/>
    <dbReference type="HOGENOM" id="CLU_469313_0_0_1"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="584" mass="67071" checksum="2E00F13E59745134" modified="2015-04-29" version="1">MASADPAPVDHDRKGKASKRSSNSYTSEEWRKHRPLITRLYFEEGRTLKDVAEYLKREFAFTPTERMYKSRLHTWGLDKKKKEHEMLDLVRQGLQQKGDDRDKVFLVRGRQVTLADALHYFNRKGIKDPSSLLEPQADAPGELSSPEEAEAKTPLSFNDEMVEPPLDTSDYEFTRSPMELDSNDKSIMPLAISPSDVAEKRLASLQQALNISHLHPMPPFRTLAVEATVVQPPNLTPADQRLLDTLFKNMQKHYMNLFTARNLSIGNTTGTWTATSDDALADRFYYSMYHGYSFLWNGQRDRAFDNFYKAFALVEGLLKDDHVGFMIYIFDLIIRHDGTGYEEPLLMLLQHLADLAKATPESEEHPIYLIANYMYHSTTSRAWLAEATLRRLLDFFQDSIGYFHPETIALLQTFATGLMNRKRYAEAAVRFQQLVDAFETTMNKTCYEVCYALRSTSEAYFHMEQYEKSLQALKAALERAECLPRPEEREIYVRCLRAMAEICSKIGRRDEAVETMRHVVDICRDAFGPEHPFSNRARMHLKSMAKGEDTSEAAIPPMVYRLGRGGSAAKYIWISRTSPTRLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3U4</accession>
    <name>A0A0D2B3U4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233566.1">
        <property type="nucleotide sequence ID" value="XM_016382863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3U4"/>
    <dbReference type="STRING" id="91928.A0A0D2B3U4"/>
    <dbReference type="GeneID" id="27335621"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08538"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36099" checksum="EC5FF84422393F40" modified="2015-04-29" version="1">MVHEILPQNPLKDEKRVQTEPLFGQLNGAKDVLSSEGATKKMQHTGLYLSQVERDSLGERPHRGLASTIAIVTGAGARGYSIGIGRAAAIMLAEAGANVICVDKDHESAQRTVEMIQYLHLEGRAVAWTADITNERQCQEVVDFTLREFGRVDILVNNVGIHGAKGTAETVDLAYWDSAMQVNVKSMIAMSKYAIPAMKQEKPGHYGKVRGRIINIASVNGIRGGSPDILYPTSKGAIVNMTRAMAAHHGPSGITVNCVCPGAVYTPMVGGFEGGTMNVEIRKSRAQRSLLGTEGNGWDVGAAIRFLASEEARWITGVVLPVDAGATAAVGFGHNMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B411</accession>
    <name>A0A0D2B411_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UTP23 sensor motif region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233894.1">
        <property type="nucleotide sequence ID" value="XM_016383191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B411"/>
    <dbReference type="STRING" id="91928.A0A0D2B411"/>
    <dbReference type="GeneID" id="27335952"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08869"/>
    <dbReference type="HOGENOM" id="CLU_053567_1_0_1"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="8">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="306" mass="34899" checksum="BA52D2D148CD0641" modified="2015-04-29" version="1">MRAKRSKKYRKIMSNYAMTFSFREPYQVLLDSNFLRTCHTFHMPLQKYLNNTLHGESKLFITRCTLAKIMADFERTRPEGSRQKRPDFLPPPTEVPLRYCKHKNNEGEDLGEVDEARCLLDLLAGQPHGNEQPKNKQHYILATADVDDKDRRRKGFIDVRERARMIPGVPIVYVKRSVMILEELSGTSEGVKRRGEKEKFAEGLVGLDRKRKRGGGEDSEDELDELAQQLENESAGVKSRGAKRAKGPNPLSVKKKKTKTTLERSGNDGHEEGGGQTKRRRRKHGGKKDQEGHEEPDGKTVETSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8Z2</accession>
    <name>A0A0D2B8Z2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235599.1">
        <property type="nucleotide sequence ID" value="XM_016379772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8Z2"/>
    <dbReference type="STRING" id="91928.A0A0D2B8Z2"/>
    <dbReference type="GeneID" id="27332512"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05429"/>
    <dbReference type="HOGENOM" id="CLU_022730_0_1_1"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="486" mass="52350" checksum="B5A70AE7779A126B" modified="2015-04-29" version="1">MSSYWLSRHGLTTTDPDDLSDFRSTPGLPQDQVDVAIIGSGFSGTAVAWHLLCGGGNDGGGTRTAATASAAPLPSSSSSPSVLILEARKACSGATGRNGGHVKPDLYFNAPLYSSIHGVRVAEELTRFETRQVFDLKKLVEEEEIDCDFELTRAIDVYTDQRVAGPVVEAWKRMKSQGYEFPPDLHFVPGENGKAEQVSGVKGALCAFSFTAASVWPFKMVMGLLKKVLARGANLQTNTPVTSIERDGNGKGWILRTDRGIVKAKKVVVTTNAYTSALLPEFGGKITPARGVACRIAVPESHSSGNKAQPPPPHLNNTYSIRFGPQEYDYLITRTDGSIVVGGAKQKVLLDDAYWRNNTDDSALIPGAKEYFDGYMQRTFRGWEGTAAEVTDIWTGVMGYSADLLPWVGPVPGRDGVFVSAGFTGHGMPRILGCAEALAGLVSGEVKGMEGTSVPKPYWVTGERLSEKRDMSREYMAGGRPKESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAG8</accession>
    <name>A0A0D2BAG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236184.1">
        <property type="nucleotide sequence ID" value="XM_016380357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAG8"/>
    <dbReference type="GeneID" id="27333101"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06018"/>
    <dbReference type="HOGENOM" id="CLU_014529_0_0_1"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238997" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="37"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="806" mass="83310" checksum="71BE59A8DBFFA044" modified="2015-04-29" version="1">MKSLISLPFLGLLAMQPVTSVAYWRMACSVSQTARVDPILNPGGVASHVHKFAGGNNVDENSTFDSLRQSTCSSCEVQKDTSAYWTPQLYFAHSNGVVEEVPNYGMTVYYVGKWRGDQSNTKPFPPGFKMISGDSTARSYDETTLTYMNTRPVADRVSFRCINAANDIPETHYINDTNCVNGLRAQINFQSCWDGSNLYLEESAHVAYLSNIDSGSCPPSHPVSIPGLFFEVLYFTNNIDQSGGGEFVFSNGDTTGFGFHADFMNGWDMDVLDNAVENCLYTDVDFGVVSACPVLAESDTQNFSRVCPEEPSVLTEAVKGKLDGLPGCNPITSGPESAPEEVCAVGVVTPVNSTTPAQPSNVISSTTTSADAATSTSTVATPTPTSTTLLSTTLQTSASIGYSSSNSSPLSESASTMLTVSTVTSNSVDPATSSSLMSATASTSPNGPLSSSTATTQFSDGIPTQNPTSSSASTAAFTSGGFSVPTTAALDVSTTQGTSQQGDVTTASSTPATVSSAPDRETTTVTVTDFVTVTVTINGVPVETTSPVTLTVTGNGPTETGSILTVTENTFTTFFSGGFGGAPAQGGPLSSPGVSQAINGMYTITGSTFTTFTFGRPSGGPHGAGFYNRHGSSGEAVNTAPVNTAPVNTAPVNTAPANAVTATPDDGGSMLTITGSTYTTFESVAISTTLEEGTSTTTLFSTTTIFVTVTPTSTTTLETAVASAIATTSSTTVAVSSTLSSLNTTVDRGIPISSASDLVPTTFITRADPNTGDPTSTTQTALTLSTALTNATFFTIRGREVMLTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAZ0</accession>
    <name>A0A0D2BAZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_05825</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235991.1">
        <property type="nucleotide sequence ID" value="XM_016380164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAZ0"/>
    <dbReference type="STRING" id="91928.A0A0D2BAZ0"/>
    <dbReference type="GeneID" id="27332908"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05825"/>
    <dbReference type="HOGENOM" id="CLU_021971_1_0_1"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="401"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="323"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW15775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="621" mass="69834" checksum="E2B79BFB74F7F2A3" modified="2015-04-29" version="1">MGSKNFARGGNRGGGRGRHGKKGDMGRTEWAKTKGDKRQRNDDEQASKRQRVDDGKPELPIYATKFSDEVLAAEERRPKKKVAVLIGYAGTGYRGMQFTHDHKTIEGDLFKAFVAAGAISKANADDPKKSSFVRCARTDKGVHAAGNVISLKLIVEDEDIVKKINDNLVPQIRVWGYERTINSFSAYQMVDSRIYEYLIPTHSFLPPHPSSFLGRALEEWAQKKDDVENYRQRQEEVAGYWEKVDKEIIEPILAEYDDDVRSILQKALWMKTGDPDDPTSDEQVPADLGDIYHESEGKDGHRIELGSSAENGTLSEQILEVGDANKSKGVSGHSKTADEATANEASEKAETADGVDAAKATGKPSRSAILQDAMKRLRQAYITAKRAYRIPKARLDRIQDALNYYKGTRNYHNFTVQKTYDDASAKRVIKSFIVNPEPILINGTEWLSMKVHGQSFMMHQIRKMVAMVALVVRCGCDPSRINDSLGPDNISIPKAPSLGLLLERPVFDSYNRRATSEMSKEAIDFDKYKTEMDAFKQKHIYERMYEDEENMNVFGNFFNHVDNFPIETFMFVTSGGIEATKVPIRHDEKIDREEQALVETDIGDGDSDVDENVRDNHGDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAZ6</accession>
    <name>A0A0D2BAZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235996.1">
        <property type="nucleotide sequence ID" value="XM_016380169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAZ6"/>
    <dbReference type="STRING" id="91928.A0A0D2BAZ6"/>
    <dbReference type="GeneID" id="27332913"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05830"/>
    <dbReference type="HOGENOM" id="CLU_054590_2_5_1"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="143" mass="15720" checksum="889AF84E71752D26" modified="2015-04-29" version="1">MASHPPGACCYQGIKHEGQPVGSISTLGDFEIYTSAPADKSTEHGVLFLTDVIGHRFVNAELVADQFAANGHFVMMPDLFYGDAVPLNRSDAFDTQKWRQGEYNASKRAHLPSDVDPVVEACITEMRTKYQCKIKQLASSRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BB46</accession>
    <name>A0A0D2BB46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236449.1">
        <property type="nucleotide sequence ID" value="XM_016380622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BB46"/>
    <dbReference type="STRING" id="91928.A0A0D2BB46"/>
    <dbReference type="GeneID" id="27333367"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06284"/>
    <dbReference type="HOGENOM" id="CLU_035744_1_0_1"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="514" mass="55804" checksum="517EB901A9D65236" modified="2015-04-29" version="1">MEEAKTLIRTAVRTFFHQPRQILIVDALMLHSVLGMDDLSVLLSAQPKDIRSLMTPLRNARLVQTHSRVEVRVGSQRGSPREYYYCPFHPAIDAIKYRIAKLRKKVEALYQQDETKRKDWRCPRCKAEYDELAILDKVGADGFYCDRCGSTLVQNERAAAEDRGHHEKIRRVNDQLKRFDDMILKIDRKDVPENDFQSAWERKKDVPRERGGKEQGQYVEIKRGDARNLKKGPEMVKVENLAINLTSGAEHDREEAERKEERKRLLAKQNQLPAWHTSSAIGPAPSSNGAAVKVESGTGTPESGTADMVLPKKEEDDEDDKKNLNIITDGAAATTTAAANSTLQDEVAAYMAEMERERLEAEKRAKEEDEEDDGDEDDDDDLEFEDVDVVGGVGGSGSGSGSGLGGGSIVGTPAGTGVDNPRPVNGVKREFDDESGPSSDANTPVSFGGGGGAAAGDGGRGDHNKRVKFENGMASAAAAAAAAAVKVEGGGVGVDGNGDGNADSDEDEDFEDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCG6</accession>
    <name>A0A0D2BCG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236536.1">
        <property type="nucleotide sequence ID" value="XM_016380709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCG6"/>
    <dbReference type="GeneID" id="27333454"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06371"/>
    <dbReference type="HOGENOM" id="CLU_088295_0_0_1"/>
    <dbReference type="OrthoDB" id="5689at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="91"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="275" mass="30600" checksum="2FBC10DE51E09BF5" modified="2015-04-29" version="1">MDRNNGQNDCWQDTTTPTVPAFASYTSTLVAHPSISIRVVQPSEIVTRPRVLDEITDVINAVYLHASDGLWATNSARTSLEEVKSFIETGEMIVAVKSDDSEGNDEDDGEDDDPTNVEERRRRQRQKTKRENPAVIVGAVRLGFRSAHVADFGMLAVLDEYKGLGIGNALLSFIEAVALEKGARRIQLEILVPQKWKHPSKEFLKGWYARKGYAFLEKDDIGRRHPKLVDQLVAECDFVVYEKTLLGREEEAGGNIDGAPPRCISELKLVSSTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCW6</accession>
    <name>A0A0D2BCW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear fusion protein KAR5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_06509</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KAR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236671.1">
        <property type="nucleotide sequence ID" value="XM_016380844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCW6"/>
    <dbReference type="STRING" id="91928.A0A0D2BCW6"/>
    <dbReference type="GeneID" id="27333592"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06509"/>
    <dbReference type="HOGENOM" id="CLU_444833_0_0_1"/>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04163">
        <property type="entry name" value="Tht1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249714" description="Nuclear fusion protein KAR5" evidence="13">
        <location>
            <begin position="30"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW16455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="68953" checksum="9295084C1F3E88AB" modified="2015-04-29" version="1">MSVARGLCRLRPTHFIFLMCLFFSQLCQGKSFLGADLTWTAVRKERNDLQPDLTDLLASRDMDQDPVFERAMHVIDNLATQTTCQQTAAAQLLITCKASGKSSNAKAVNHELLERSKTAYAVRVAVCETGEGRATIPPACRPVLDIPRRLQGEIDVVNAKTLASCLEGLMLEHYYWTSYSNSRQDANILCQASTLEATRLDALLSYQKLAELLPEFREVLESTRSRWLGFLKQQEQEAQKLADTQQKNHADLKTQHEEHAKSFRQVMNNAKEDLNAVSQQLRQYVVETGSGLGHTHETLSHVLSDFTMLRDLVAEVTSAAGKTSAEIAAIHAEEMHNVRDIALATTESLNKLLSTEATQGINALLQQFSIGLDAISSSQIKQLARLDEQLRLSDDLAEAQRMNIALGQEMYDTSSVLSSQLHTASAAATDVSSRIDKVNEALTRVEEASSVLSALFSFLALPTHMMQQLHLRLLILFSMPAIILFFWKPRKYPYSVMASYVFLESLISIYAQYENVISGSVRRLSIRSQDATTWAFSHAGQHYTLLFSAFGILLVMSCYAILVACCKKARHSRKQLLVESSHGNEDFQQLYVGYRLRGNKQLSSRSADRFRRAATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BD87</accession>
    <name>A0A0D2BD87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04108</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237134.1">
        <property type="nucleotide sequence ID" value="XM_016378457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BD87"/>
    <dbReference type="STRING" id="91928.A0A0D2BD87"/>
    <dbReference type="GeneID" id="27331191"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04108"/>
    <dbReference type="HOGENOM" id="CLU_009020_1_1_1"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="35"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW16918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="532" mass="57630" checksum="CA5091DD5F1FC984" modified="2015-04-29" version="1">MPGLTASHASHSGTRRHGHTPPPRTKRDLGGTPGNASWLSSVVNLLNTIVGAGVLAMPLAMSHMGILLGTIVIIWAGVTAGFGLYLQARCAKYLERGSASFFALSQITYPNAAVIFDGAIAIKCFGVGVSYLIIIGDLMPGVVRGFADESSLSPFMFDRHFWITAFMLVVIPFSFLRRLDSLKYTSVVALVSIGYLVILVVYHFAAHDTLPNGHYETPLRVFKWAGVVPTLSSFPVIVFAYTCHQNMFSILNEIADNSHFRTTSVLCASNGTAGFIYLLVAITGYLSFGNEIGGNIVAQYAPAVSTTIGQAMIVVLVMFSYPLQVHPCRASLDAVLKWRPSDKLKAKLRSASATPRSVDSSPPRDVPLLPVAKKRNTEMSETRFAAITTVIIICSYIVAMTVSNLSAVLAYVGSTGSTSISFILPGLFYYKISSPDSPLHQRLLKEEDDYDYADSDAANSDDEDDHDGVGGEEHQSLLANSGLLSLSGVSLLKRTKNLRRNLLRRLSLALAIYGLVVMITCLIMNTFFLATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEP2</accession>
    <name>A0A0D2BEP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_04241</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237266.1">
        <property type="nucleotide sequence ID" value="XM_016378589.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BEP2"/>
    <dbReference type="GeneID" id="27331324"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04241"/>
    <dbReference type="HOGENOM" id="CLU_001721_0_0_1"/>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000552">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000004">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="877"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1110"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1379"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="348"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW17050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1610" mass="179530" checksum="EB598E645F34179B" modified="2015-04-29" version="1">MDNIRDPNIYIRRPSGTSRQYAVPAESNAYRHARNNSTNLSYAEHEIVRQRKTPYGKLSEQDTAALDKTIQVPPIKHLLLSSSPEFQTNTPSYSSRWATSNHVSRSNAAAGIDLGRDGRQERQHKSHGNSQSYSYRPALEFSVGLDSMLNQTLPLYPTQRYYLQPGSNIPTVLPATLQSQFGPTASAGQEYYGPYWPDGTYNPYRPAAIRDSRFFPPAPTERFPLEHFQHPRTFQQTTHVPLARNSGYMQTVQAPLLGMPLTTVESPAAKWNAVQNAYQNAQYPFPQQYSPPEHLMTDPITASRPLLSSIVPGPSSERIAFRDRTFAWANKVYTDLLETIRWTVKDQRASGGSTSDSRPVQKPAIFPKPPRRSGSHFHETSLDRISTNPSTPKFYPHYNNEHSMPEIPSRPQTAIYRPQQAQAGAANQHLSASTNGSNTHYQPRDRIPEVRQPGQSLADGFTRPPSFESANSALRTMELLCHEADTPWVDGMLLAGCLAYGLGNYGKAEEWYQAVLKQEPGHIEAMSNLAATCHALHRREDALKYWSDAVSLRPSYFEAVEHLIGLLCASHRAREAVSVIEYVESTLRLPPDDSHTWSELSDAESDSKSHTSSIATVASYDHAHHDFDFDLSQAFGSGSETLMPGFGSSGFAIPGVDNGRILALIHAKGNMLYALGNNHGAAAAFEDAVLISTGHRKQGIKGLINNILRACLRNIRDPEYVRSKLEGKEPILLAPEHAEATARNMFPPDGDLPGLEHITPAFAVQAAVSTTSNSLLSLAKIYQDGMSNATDIGTLKSPSTREILALYYLSLSLQRSPSTANNVGILLAGVQQSVHPAHLAESHFSQISSIPGVSAGSGISLALMYYNYGLNIDQKHAHLFTNLGSLLKDIGQLGAAIKMYERAVSCDGSFDIALANLANAVKDQGRVADAIVYYKRAVGANPDFAEAVCGLATALNSVCSWQGRGGICARDKLRDRLHVDDNGMKHAPYRPYGWINRVVEIVEKQLKDGEHWGCGTLTSSVIDSLSAQLSLHKLSSHDNVREQTINTLRQALRSWSGQKWEGSRIVRLVERAIRYIGWQWYQDRYVKRKEYSARKYSRPLLPSTLSPPSAPTVLPFHTFTAPLSAKQIRQISQRNALRISMCTLRSAWLPATVFPPPAPPDPCLNVGYVSSDFNNHPLAHLMQSVFGLHNPSKVRAFCYATTASDGSVHRQQIEREAPVFRDASSWSVERLVHQIVKDNVHILVNLNGYTRGARNEVFAARPAPIHMSFMGFAGTLGAEWCDYVFADSISVPPDTLSPWRRNVDIEDRLRPDALVEDMEDWVYSENVIFARDTFFCVDHKQSAPDVSKGPPNFKDSLKRETAWEEEQETRWKLRKELFPTLSNTAVILGNFNQLYKIDPATFESWLQILKMVPNAILWLLRFPDLGEQNLLKYAREWADADVASRVIFTDVAAKGAHITRASVVDLFLDTPECNAHTTAADVVWSGTPIVTWGKWKYKMCSRMAGSIVASALPAGRAGEDARRELLVQSEKDYVDTAIELARGLKYPSHESGGQKIGRGKGRLMDYRRMLWEGRWSSRLFDTQRWVRDLEVAYWSAWEKWEKGEGGDIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BG37</accession>
    <name>A0A0D2BG37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_04749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237771.1">
        <property type="nucleotide sequence ID" value="XM_016379094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BG37"/>
    <dbReference type="STRING" id="91928.A0A0D2BG37"/>
    <dbReference type="GeneID" id="27331832"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04749"/>
    <dbReference type="HOGENOM" id="CLU_035117_6_1_1"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF81">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="9"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="183"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW17555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="329" mass="35075" checksum="4538207AD64EE32D" modified="2015-04-29" version="1">MDLSKISGLGFVGLGAMGLPMAGHLAAKLPEDVQMFVFDINQASVDQLHSEYSKRVVKCSSAKEVADKSEIIMTMLPEGKHVRLVYMEGGDGTICSSDVAGKLLLDCSTIDTASSLAVKEYINKKFPTTSFYDAPVSGGVVGAQKGTIAFFLGCDGADPNMPHLTTLLKMMGKDVIPCGGPSKGLAAKLSNNYLSGTIAIAVSEAMDMGMRSGLDPRVLHKVFAAGTAQNTISDRFCPVPGVYPEAPSSKGYTNGFKVQLMRKDYNLALEMAKRVGSKNVLGEAGLATYDGASNDPRCRDLDSRVVYRYLGGREDWQQDADEATASKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BH44</accession>
    <name>A0A0D2BH44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230890.1">
        <property type="nucleotide sequence ID" value="XM_016385946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BH44"/>
    <dbReference type="GeneID" id="27338721"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11638"/>
    <dbReference type="HOGENOM" id="CLU_082451_0_0_1"/>
    <dbReference type="OrthoDB" id="3596006at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28185" checksum="DC2B07369477A740" modified="2015-04-29" version="1">MAVIWGLDLRDLQWGKFKSSYMFGNKDYHLRRTKFVVYQIAMICCVVSESIGTAALTDYVKQQSRIERLHSSASVHNDDFVGIASYNIFVGIAVATIFGAAFFFDLFFPERYEPRNIRWAWRISALVVTLMTFADAIALTVIVATGNAWISANSEDAAEIARKALNPPLRYRDNGRAIASVVFIWLGLVGTIASCIILWLYYHHLDTYGPKSHTARMRDEIDRSILKAERVNSDTTAREQAYKYSSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIA9</accession>
    <name>A0A0D2BIA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238914.1">
        <property type="nucleotide sequence ID" value="XM_016377344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIA9"/>
    <dbReference type="GeneID" id="27330070"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02987"/>
    <dbReference type="HOGENOM" id="CLU_642499_0_0_1"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50728" checksum="5C99ACC281EF47CE" modified="2015-04-29" version="1">MQGRRRTPVTAASGGSQNSPKPTTTAPSLSAYRFATYDDLQHNSLPRLAFEMDEYSHGMVKYLFTNWIPSLYPQKLATVHHHRLFEMVYTDSITCAIFLTYGFSQSAFELVEINCQQKSLTSGDGSRKRYLFRSKEACLRMMREMFTTSWPMSARRLFFASVSLSGCAFIVNNPEEGRMHLQGAVNIAEAIGGFRNLGELELEASLLWDVHLASLTGQKPVISGIEVSHIAQTLLPQVPEWLVDSGLRFSALFEPSLSSDDKSDVCGALRGLFYAAELINADSTQSEDRINETLIIRTLVAGHQLSRCAPTTNSTDVAPEHNICTLESLRLAGMLAIFTTHLKATRKIHLFEKVSRDLEVLLRRSDVETCWRQYPEIMMWIFFAGAHGSPNVYRTQWFIQNISRGAHSLGIDDWHQARMVLRKFPYIVKEFDKPFEDMWNSSQPGFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIG9</accession>
    <name>A0A0D2BIG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP40 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238606.1">
        <property type="nucleotide sequence ID" value="XM_016377036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIG9"/>
    <dbReference type="STRING" id="91928.A0A0D2BIG9"/>
    <dbReference type="GeneID" id="27329761"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02678"/>
    <dbReference type="HOGENOM" id="CLU_069847_0_0_1"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="246" mass="26334" checksum="29B17EA3EC1C92DC" modified="2015-04-29" version="1">MATTQIVLPGDIIPATQLPTSQKRKIGRGLKQDAATHEYMATVGGLLEIDFRRKAAQVSTPSARYVPKPGDLVIAQVRGSSVDFFHVHINAHSPPAVLPQLAFEGATKKTRPNLKPNDLVYAKVVSAQKNMEVELSCVNPSTGKAEPDGLGPLTGGGMVFDVSPGLAERLIKKIAVVALDDLGARLPGGFEIAVGCNGKVWVECAEAGVRGTCAVGRCLREMDELELTEKDQRKLVNRIIADFERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIM5</accession>
    <name>A0A0D2BIM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Caib baif family enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231435.1">
        <property type="nucleotide sequence ID" value="XM_016384833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIM5"/>
    <dbReference type="STRING" id="91928.A0A0D2BIM5"/>
    <dbReference type="GeneID" id="27337602"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10519"/>
    <dbReference type="HOGENOM" id="CLU_028036_1_0_1"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025496">
        <property type="entry name" value="DUF4387"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14330">
        <property type="entry name" value="DUF4387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="65"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="244"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4387" evidence="2">
        <location>
            <begin position="508"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="68219" checksum="B20803A467FD0E1D" modified="2015-04-29" version="1">MGSLAQSDFTILTPCAILGYGFRSDHFWLGVDKYRPSAIIVDAGSTDGGPYKLGLNKMTCGRESYIRDLRPMLQACYYRKVKVLISSAGGDGSNAHVAEMLEIIREIATTEKFTFKVATITTDLDHETIKAKLKKAQIHPCGPVPDLTINDIDNAIEIVGQMGAEPFLSALQNDPDIILSGRSYDPAPFAAFCLHQGVDPGVAWYLGKIMECGAFCALPKGRIMVGRVRQSSFDLTPVSPFERCTPVSVAAHTLYEKTRPDRLPGPGGVLNLDRVHYEALEDGRTVRVSGARFEPSVTYQVKLEGVEKLGHRTIFIGGIRDPILISQIDEFLETARAYTRKLFPELDRDPSCQLKFQVYGKNAVMGPLEPNNHQAPAAVPYEVGILGEVVAPTQEKSHAVANNVRASILHMPYRNQMATAGNFASPLSPHEQDAGAVFRWNVYHLMDLQRGEELALFPVTHLTIAGSGSVVSEPESTHYSAEELEEFVKGRPEPVLPKAVPSDEAVRMMDIAKIVRSKNAGPFELTLDIMFDSWEAYQRVKEANVLTNDVICKLYRVQDDDILTNMYFDPAMAWKTTIRRPWEQGSIGERDTLGTQQYAPLLYIMVPPRDKTQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIQ5</accession>
    <name>A0A0D2BIQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231460.1">
        <property type="nucleotide sequence ID" value="XM_016384858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIQ5"/>
    <dbReference type="GeneID" id="27337627"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10544"/>
    <dbReference type="HOGENOM" id="CLU_028412_0_0_1"/>
    <dbReference type="OrthoDB" id="3516776at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="557" mass="61575" checksum="24E6CDBD86306B69" modified="2015-04-29" version="1">MAVGWIDLPQGWRLQDVQAVLNVVIATLSAIAIFVCARWCWQSSFPKIGQRSVPLKDLLTIGTLGEALDVVMLLRWRSLSIQNSKLLGQCVVVVFFSVVALVSGPIARYSSRHSFKLNPLEISGSVAWRFHDCIISAPVTWNATFTSLDRARFPHDQLLDFVPDTTVDWRYRAEEWNSSWSFDCLPTHETAIDLEDVGNCTSNMPDEIPGLQRIISTEMFNTSNGEMGWWHGDYREDNVLKDVLMLIAAVKTTEIDDTSDQVHEIALELAAVHMHNVNVKPEDEDSACDFGTGPVQSASYTKIQCVVRRLPGRMDDEYAAFPDGMVPSCLAQAAVQNYQARFISESVNGKPPGIVAPEDLVRFTQVWMATKDTQNLLTVARSISVQVGIVQLSAAFLAFVLLVFVLIVLGLAAYAYGYLRHRRVFKSRPQSKIDWMIETIDETRGGHGGDEDGQPTPNLQSDETKTGRAEASSAEKRRSLFENAIYHLDREVCAQRNPDCVARSGANEADESPEGLLGEGDSVRPTTTKTTPNAEKPSDSLDTRVSTEVVGAPIVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJS7</accession>
    <name>A0A0D2BJS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory factor Sgt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231735.1">
        <property type="nucleotide sequence ID" value="XM_016385133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJS7"/>
    <dbReference type="STRING" id="91928.A0A0D2BJS7"/>
    <dbReference type="GeneID" id="27337903"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10820"/>
    <dbReference type="HOGENOM" id="CLU_006241_2_0_1"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="71781" checksum="C371C1B5CD8CCD8A" modified="2015-04-29" version="1">MPPTEEDIAWFRSTFHPIPKPALPDDTIEYSLYILSPSESENDSETRVRLRDVQKQATDLQRQYLKDYIWQRQGFSLELNKEDGLSLLRGRTEYGDSVEDEWVVVWLLRELTRKFNDLWVKVTDNDGEFLLIEASGTLPAWLEPEVAENRVWINNGQLKIVKPAANARSSRRTDEKLTLGQARDVLLREPKRIMHSASIEEEAFFRLRNYPAQIAENMHNAVITVPRKIAFLLHQKPAYVSPAVEAFYLRDPIALKPLQKKENHDSMVFPPEDAVTVSVRFPRVAYAQLKSQDFAAPAVFAGFMPSRTESKAFAQAETGMKVTCGFEMLVTDSQYQDRPAVREMKMLLDDLESGDESLPSDDEIKQWDKREDDEKWLDIDFNDLEKELDGQKGKKPGFGDKAAQENLQRIVKQFEDFLNDDKTGPDAEGLFGDDSDDDDLMDDDDDDEEGEDKEASFGEDEFTKIMQEMMGMPPEVMKEIMSGKLPADAHDPAARAKLRRPDEVPGRRVEEVVDDSDEDESEDMQAFMKQMERELRGSGALELGSAQAKQPAIKARGKDVKKPGQAVEDELSSDDDIDNEIDIDLARNLLESLRAQGGTAGPGSNLMSMMGFDRLHDDDDDDDDEVVAGPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK87</accession>
    <name>A0A0D2BK87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239191.1">
        <property type="nucleotide sequence ID" value="XM_016377621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK87"/>
    <dbReference type="STRING" id="91928.A0A0D2BK87"/>
    <dbReference type="GeneID" id="27330347"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03264"/>
    <dbReference type="HOGENOM" id="CLU_098428_1_1_1"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="130" mass="14765" checksum="C5E04B8A481C5D65" modified="2015-04-29" version="1">MVKTSVLNDALKSINNAEKAGKRQVLIRPSSKVIIKFLSVMQKHGYIGEFEEVDDHRSGKIVIQLNGRLNKTGVISPRYNVQLRDLEKWVVKLLPSRQFGYIVLTTSAGIMDHEEARRKHVAGKVIGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK98</accession>
    <name>A0A0D2BK98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239201.1">
        <property type="nucleotide sequence ID" value="XM_016377631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK98"/>
    <dbReference type="STRING" id="91928.A0A0D2BK98"/>
    <dbReference type="GeneID" id="27330357"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03274"/>
    <dbReference type="HOGENOM" id="CLU_061230_2_1_1"/>
    <dbReference type="OrthoDB" id="3928002at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF1">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239167" evidence="1">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="210" mass="24090" checksum="48D2D0203EAE6738" modified="2015-04-29" version="1">MVIGLLILTSIPTVTGVAQAISAQKTRDERQKDERRMKKFHIDVHCEVESSRTREIRDKRLVLRDDRVWIGPTEALNPCPEGYVAECFYIEYPDNERVPIPIGLVSQVRDDPPLLNWLYVDKDTMELKYGNKSASIDHHVGPWDWTEDEQGITFDETEDFTAVEDPRTHKWQIYCDMDNDGLSRFVPIGRQKIHVGLMRTLIPGASVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKD5</accession>
    <name>A0A0D2BKD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231965.1">
        <property type="nucleotide sequence ID" value="XM_016383342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKD5"/>
    <dbReference type="GeneID" id="27336104"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09021"/>
    <dbReference type="HOGENOM" id="CLU_894388_0_0_1"/>
    <dbReference type="OrthoDB" id="10681405at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239172" evidence="1">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="311" mass="33539" checksum="73ABA0798CE41B2D" modified="2015-04-29" version="1">MRLSPSSAVLLFAIFVSASPPSETTSPDLIVPEHGVHANASTATTAAAGPETTPPPEDDLVLQQLNKRDSSDTCGVISTTTLTCAESKGPCVWDPTPGGPFGCCPINEAGHADSSCIFEVKCIDFADYYLDSSTEPPDQATLVCFDNELSTYVDDNPYDVAFAAAGSSVVENHIEMPKYKDMMAENMPGTLSDYDDTDSIPLFAINDDQRAAAIEPFDYFLSEVLELLDSSAMLPRQAEDSDTTIEMEKELTRTQLKAMLFQMIALNPDRCSVARQIRAYTGRVNVTTTTLNIAAGPLGPSFTTVFDKHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKM9</accession>
    <name>A0A0D2BKM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="19">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PV08_00060</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="19"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239704.1">
        <property type="nucleotide sequence ID" value="XM_016374428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKM9"/>
    <dbReference type="STRING" id="91928.A0A0D2BKM9"/>
    <dbReference type="GeneID" id="27327143"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00060"/>
    <dbReference type="HOGENOM" id="CLU_011312_1_0_1"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000001">
        <property type="entry name" value="DNA repair helicase (Rad3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.20:FF:000001">
        <property type="entry name" value="DNA repair helicase rad15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="23">
        <location>
            <begin position="7"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="248"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KIW19488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="816" mass="92912" checksum="D0E35420DCFAC85B" modified="2015-04-29" version="1">MKFFIDDLPVLFPYPRIYPEQYAYMCDIKRTLDAGGHCVLEMPSGTGKTVSLLSLIVAYQQHYPEHRKLIYCSRTMSEIEKALAELKALMKYRSEQLGYVEDFRGLGLTSRKNLCLHPSVKREKSGAVVDARCRSLTAGFVKEKKERGEDVELCIYHENLDLLEPHNLLPPGVFTLDDLLKYGEDHKQCPYFSSRRMMSFCNVIIYSYHYLLDPKIAERVSKELSKDCIVVFDEAHNIDNVCIESLSIDLTEDSLRKATRGANNLERKIEEMKASDEEKLQSEYQKLVEGLREADEARAEDAFMANPTLPDDLLKEAVPGNIRRAEHFVAFLKRFIEYLKTRMKVLYVIQETPPSFLSHLKELTFIERKPLRFCAERLTSLVRTLELTNIEDYQPLQEVATFATLVATYETGFLLILEPFETEQATVPNPILHFACLDASIAIKPVFERFSSVIVTSGTISPLEMYPKMLNFTTVTQESYPMSLARRSFLPMIVTRGSDQQAITSGFQSRSDPGVVRNYGALLFEFAKITPDGIVVFFPSYLYMEMIISMWQGMGILDQIWTYKLLLVETPDAQETSLALETYRTACENGKGAILLCVARGKVSEGIDFDHHYGRTVLCLGAPFQYTESRILKARLEFLRENYRIKEQDFLSFDAMRHAAQCLGRVLRGKDDYGIMVLADRRFQKKRSQLPRWIAEEILDGQTGLSTDAAVGMAKKFLRSIAQPLLPGQKAADGTTKGKDSWTLRELEAFQREQGLKRGQGDEGREGPHFHDYMHSEVNNPTAAQNGTNGHASGLDEFDEEIADEELLMAERMEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKP0</accession>
    <name>A0A0D2BKP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450 alkane hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_03442</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239366.1">
        <property type="nucleotide sequence ID" value="XM_016377796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKP0"/>
    <dbReference type="STRING" id="91928.A0A0D2BKP0"/>
    <dbReference type="GeneID" id="27330525"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03442"/>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49846" checksum="8066C8ACAB0039DE" modified="2015-04-29" version="1">MGVKFFPKTVILLLFTLVAITCLILTIEPENIKTVLSVRFHDYSIHYRLEPFRPLLGEGIFSADGEHWPASRALIRPSFTRDQVADLRELEKLVGDLLALLPRDGMTIVDLQELFFRYTIDSATSFLFGQSVGSLKKAYEETEFAEAFHYAQEAVLTRATTGPLNLFYRDRKADECNRICRNFAQQFVDDAVQAVPFKQGAEDTVNAQPDTDTKHQKHIFSHELASRTSDKQRILDELMNVLLAGRDTTACLLSNLFFVLARSPVIWQKLRAEISVLQGRPPTYNELRALKYVRNCVNECNSPSHPPVPRNERMAMRDTVLPLGGGKDGLSPAFVPKGTVVSWNVYAMHRRTSIYGADAEAFRPERWEDGKLRPHWGFLPFSGGPRVCIGQQYALTEASYVLVRMVQNLAAIETADPHPWEESLTLTLCSRNGVKVRLFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLI4</accession>
    <name>A0A0D2BLI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_09298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232240.1">
        <property type="nucleotide sequence ID" value="XM_016383617.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BLI4"/>
    <dbReference type="GeneID" id="27336381"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09298"/>
    <dbReference type="HOGENOM" id="CLU_000604_57_4_1"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF119">
        <property type="entry name" value="ROA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1079"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1121"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1159"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1187"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1272"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="71"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="704"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW12024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1315" mass="145846" checksum="6E540DAF0A5BBAD9" modified="2015-04-29" version="1">MGKQSISHERDLRNQCLGASSRSPSTSVELLANFQNELSGYQTVDVRVRHLSVTVEAVAPSPLSSLDALRARINGSKKTPTSIKKILDDVSADFPSRSLTAIVGASGSGKTMLLNVISGRMKAHKFRQSGTVTYKSSTNNCCGKVDAAYVLQQDVLLPTLTVRETLQLAADLRLSTTKTKAERCTMVETVIAELGLQTCANTKIGDPAHNKGCSGGERRRTSIGIQLLADQPILILDEPTTGLDAASAIQVVQTLSRLARKGKTIIMTIHQPRSEIWRLVDNIVLLSRGSPVYSGSVKQCLPHFERMGYKLPSFFNPFDFIVDLAAIDIQSVELEKNSSIRVDQLLKAWASESASYHEKISQSFTNKSLHSNRATSYRDLFDELAHETMVLTRRTFIVTYRDRLGLFASIIEATSMGMISGWVFYHLGGDLSGIKSRQGALYTASAVQSYLVLVFETYRLSVDIEIYDRERIEGTSRPVTFVLSRRLSRILVEDIPVPILFSLIFYFMAGFRPQARQFFTFLVIQTITHLASINLASICVAINRQFMVASLLANLSFTLQTFACGYFINTHSLAVWLRWTKWISYIFYAFSALCTNEFRGHMYDCPYSGEASNQACKEYWGEYILEALNVPSDWLWRPIVVLVGFTALFFGLSILLLQLITIEVKLARSRQSEVSCGEDHERSTRTTDAPTSINITLDGFGIDLETRRLFKAMSRKQICAPITTNFESGSLNVIMGPSGSGKSTCLNTIAQRPQSSPVSRYLSCGTIRLNGAIATDSVLRSICSYVPQDDTGLLPSLTVRETLYFAAQLRLPHFVSHEQKLQRAESILLRLGLKECADTLVGNEFMKGVSGGEKRRVSIGIQILTDPKVLLLDEPTSGLDAFTADSIIKVLQSLADEGRTVILSIHQPRSDTFRQFGKLLLLTHSGDVAYAGGVPNILPHFSEIGYTCPDATNPADFIMDLVSDESFCCHQQQEGILLSSIKADERPLATSRVTESPSGPTTFSREGRLSLPAEIGAYKRSQLPFSRAFPILLRRGMINLKRQPELLIGRVTQIMGLGIVLAAFVAPLQNDYYAVQSRVGYILTMSSMMFVGMLNSIAMYPTERDIYYHEDRDNTYTVEAFFCYYSFVEFLFELLGSLLYAVLTVFAVGLPRTASQFFLMTYSALCVVSCGESFGILFLTMFSHTGLAVSVMTVMMAISVSLAGVLSISLDRFLTVVSYVSPVKWQVGALLSYTLRGTTFTCSDQQRLGNGTCPIQTGDQVLQLYKLDVSTLQYALILGAIAIGYRLLAYLGLKTRRVDWTRCMRMELPGRKNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLI5</accession>
    <name>A0A0D2BLI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239646.1">
        <property type="nucleotide sequence ID" value="XM_016374370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLI5"/>
    <dbReference type="STRING" id="91928.A0A0D2BLI5"/>
    <dbReference type="GeneID" id="27327085"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00002"/>
    <dbReference type="HOGENOM" id="CLU_1030715_0_0_1"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="270" mass="29470" checksum="CDB35779A7EECEEA" modified="2015-04-29" version="1">MQRADCTYPAVRRLRGAGKKERHGKADQMIPLMQSSLSTATCEPLCIKSTEFGKDLFIAKLPAFLAPHSFKYNLETVQAALDKARSRDEYTSILPDNIVRYLIEASFEEISLPRSVVASRLELTALFDQQRRECPKDPGSNPAIWVLINATIALAVRAKTVDSPALRLSDIASAYHRNATKALGQVLLAAPSVVSVRALLAMAVATRVETGQLAALILTNSAKLVLQAILSQPKSGASDDLSTLKLLHDAVNRWGQENIKHKDPNTCEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLL6</accession>
    <name>A0A0D2BLL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00413</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240054.1">
        <property type="nucleotide sequence ID" value="XM_016374778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLL6"/>
    <dbReference type="STRING" id="91928.A0A0D2BLL6"/>
    <dbReference type="GeneID" id="27327496"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00413"/>
    <dbReference type="HOGENOM" id="CLU_014245_1_0_1"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF12">
        <property type="entry name" value="RFEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="279"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="960" mass="105750" checksum="C62C6454BDC14CA8" modified="2015-04-29" version="1">MATTYGMPPYQNNTHLPPINYSQLPPAGQNYMQQQYRNDLPRYTSAPSTAPVPSPAPDNRYASQMNPQGSMSGLPPTSMLPSPHQQPQQPPQQQPPQQHQGYPQQPPPRQNYPQPLAPAPPRPNIDALGQGYPQPDNRGQPWTGAESMPGMTSDVGRDPTRTHVVGSQGRRGILPSAPGRPPVMANGVNGSTKSNAVPQKDADGKFPCPNCTKTYLHAKHLKRHMLRHTGDRPYMCVLCNDTFSRSDILKRHFQKCSVRRGNPTGASHLSNPAAHLKKSQQAAAKAAAAAGQNNSPANASTPTSGVMANPPYTTATMPSTSAPTTTASAPGMAYGMGANGQGDMQRQGQAMQAGAAPGGMDPNGHASWQMHDARGNQLMYQSTSTNPNHYGMQPGGGDDKRNVMPGAHHMGDEWNHMFPPGGNEGYMNPMFGGYDQSQGDVKKEYESHEGGSNGYYIPSTSLGADGTLGPPLWNLHAYQQDLLQAKVNALLTFVFPGGIQESLQEQQNNLNLQAYLTVDAIQHFLDLFPNFQGHFPWLHIPTFDFLTAYDGLALVIICTGAVYSDRISQDQVRVLMQRVKEGVERTSSILKNLEHGIPYSQFSASGIEYQELLALTILQTLVVWHGGPDERALARAESKRIMYLVRTFDLLTLAGPDDPIGYSYLHSLQPGDEADPSRWDWRSWVEQEKRSRLMFSVFLWDAAMCMYFNVPPQFSSAEIKLPLPCDDAAWEAQDAETCAQALGLRGPAAQSRINVTGSHRLKQLEMHHAMSALHSTSVLMHPRTTNIYSKFILIHALHSEIWQVQRQRSFGSPGASPSSNSSLEQTTNMYNSLNMALARWKQSWDADLPIQYPASDGYSEAPKRIGFCRDGVHFYWLARAFLQPDRLHDWQLPPDTRLQQALQGLKQAREWGRTDGARRGEEPGSVAYIDENYAAASEVLDMRGLFRPLAMISDEPAAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLV8</accession>
    <name>A0A0D2BLV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239756.1">
        <property type="nucleotide sequence ID" value="XM_016374480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLV8"/>
    <dbReference type="GeneID" id="27327195"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00112"/>
    <dbReference type="HOGENOM" id="CLU_010480_0_1_1"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF14">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="427"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="810"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="866"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="901"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="953" mass="106410" checksum="7C6389C7B715F509" modified="2015-04-29" version="1">MSQKGHHGFSREGFQPLTHKTSRDMNNPNDITIDIPMTRVTTNNSATGARKQGLSPSRADQNTDSSDELDEKAGRLDHFHKGPEGRRRRYKDQGLENKTREDGTLNAVGRFYKKIYNASVITRYFIYVAPLALAIAIPIIVGATAAPNARIGGVKIVWFFSWIEVLWVSLWISKLLARFLPYLFQFFSGVVSSGTRKYALVLTALEIPLSLVGWAIISLSTFVPIMTLNPDQRARGETGLKDWESVVKNILFACWFSSLLFLAEKFLIQLLSISYHRKTFDDRIKESKHNIHLITLLYDASRKMFPMYCREFLEEDYLINDTLDLAEASKRTSFLGGHKRSGSATPMRLIQNVARVGDKVTSAFGNVAQEITGKKVFNPTSSHSVVVQALERKHSAEALAKRIWMSCVLEGKDALGIEDLIDVLGSDHEDEAHEAFDALDVDGNGDISLDEMILRITEFGRQRQSIASSMHDVDQAIHVLDNLLCTVVFVGVIFIFVAWLNKSFTTTLATAGTTLLSLSFVFAVTAQEVLGSCIFLFVKHPFDVGDRVDISDNQYVVERMSLLYTVFRRIKDQKRTQVPNIVLNAQWIDNVSRSKAMREQISIFVSFDTTFEDIDLLKKEMTNFVRDKDNARDFQPDLDIEVLDVADQSKMELRVEIRHKSNWANESVRAARRSKFMCALTLALRKIPIYGPGGGGPAAGDKANPTYSVAITDEVAAKNKEEFDEAKDKARLVPLKSLHREQSNLKKTDSDGKDYLGMSTGVEATEAAAVDHLTRREVAVDPAEPLDEHQELVLNKQRTQDVEEIKNLLKRESTTGRRRAARHSGLSVQDSNDPSMLGSRTIPNFAGPSPQVPVDGFQPERVSYFEDTNQPMTHPTASQSDWTNVAPLNYGQQPYRPSGPPASASPAASAPNSSRFVAGNAFSQQLHSPPQVSRVPVPGMPELKKNLTQSPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN01</accession>
    <name>A0A0D2BN01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_00893</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240534.1">
        <property type="nucleotide sequence ID" value="XM_016375258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN01"/>
    <dbReference type="STRING" id="91928.A0A0D2BN01"/>
    <dbReference type="GeneID" id="27327976"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00893"/>
    <dbReference type="HOGENOM" id="CLU_036204_2_0_1"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="11">
        <location>
            <begin position="78"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW20318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="460" mass="50204" checksum="27527DD3D8F13AED" modified="2015-04-29" version="1">MATDTTTQAAIDDIFNFDSTDDEDPFKDTNQTSRVNRDDKSTSDPSHKRKADNDDGSDADLGINKEVKVNKKRKPIAKLDEARLLSAPGIPKLRALARSGKFSKKLRLKGKGHEFSDVARLLNYYQLWLDNLYPRAKFADGLQLVEKVGHSKRMRIMRKEWIDEGKPGYARKWGQKDDQDQDQDQAVSDLFGGNNSAENSSTPSADATAVHGETGGDSLFIPDSRSGNEMPPEDNLPDDDELEALLAEQDTASTVASKATAPAKPTVDADSEGEDDLDALLAEQESRRPVHPSNPPAAKTNKSPFDDDDDVEGMDEDDDLDALLAEQEARYQSTSRLRGPSLETSSKPPQHDEVDAEDDLDALLAEQEARQKTPRAEKAAGNSIDRTDNLPVTRDGVNEDNAGGEEMFSSSPVRTTQHSRAGAGETSSARTAAQPEEARTQEDTEDLEAGDMFSSSPVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN41</accession>
    <name>A0A0D2BN41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240186.1">
        <property type="nucleotide sequence ID" value="XM_016374910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN41"/>
    <dbReference type="STRING" id="91928.A0A0D2BN41"/>
    <dbReference type="GeneID" id="27327628"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00545"/>
    <dbReference type="HOGENOM" id="CLU_2038095_0_0_1"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="121" mass="13353" checksum="A730B46D27A24950" modified="2015-04-29" version="1">MASLGVVIAQISRIQKALDDEAEHNDATARRASGKPQACICQLSAILILLVGAWRFLQHQEDILRGLTKFYFGGVYLTGVVVLLARLLSLLFTQIVHKGIQQYYIVIQLLSSMSAETPVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN43</accession>
    <name>A0A0D2BN43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_00933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240574.1">
        <property type="nucleotide sequence ID" value="XM_016375298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN43"/>
    <dbReference type="STRING" id="91928.A0A0D2BN43"/>
    <dbReference type="GeneID" id="27328016"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00933"/>
    <dbReference type="HOGENOM" id="CLU_006937_8_1_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW20358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="60938" checksum="60514B0F45826E37" modified="2015-04-29" version="1">MSSKPKEVDAVVVGGGFGGIRLVHLLLHKLHFQNVVAIEKGSELGGTWYWNQYPGAQTDTESWVYRFSDDRDPPKWDTRYLKAEDLQVQIVDTARKSDVLKNYIFDNEVVSAHYDAASNRWLVATDKGLEFAATYFLTALGILTNPYVPDFPGRESFKGVSFHSARWPKGLDVRGKRVAVIGTGPSGSQITAAIHPLVKNITVFQQRAQYIVPVNDRPVSEEEKKDIYANYNGIWDTVFNSLFAMGFAESQRSALAVSEAERNEVYERIWNKGGGFRFFFETFNDLGTDVDANETAAAFVRGKIAEIVKDPETARLLQPKGHYGGRPLCTQGYYEAFNEPNVSLVDISSNPIAAVTPTGLELRDGRSLDDFDVIVYATGFDGVDGAYHNIDITGRDGLKLTDAWKDGANALYGVSVSGFPNFFTVTGPGGPFANMLPSIELQGDFIVSLIDEVDSRKNKIREDGDHDNNKGRAGGRGGTVEADGQAQKEWAATVQAISRATVFDKVKSWIQNDNVEGKKKYSAFFLAGLQSYIAKLTEEKESRYPSFVFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ55</accession>
    <name>A0A0D2BQ55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233475.1">
        <property type="nucleotide sequence ID" value="XM_016382772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ55"/>
    <dbReference type="GeneID" id="27335529"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08446"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF49">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="246"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW13259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="753" mass="80565" checksum="230949796A0FA0E5" modified="2015-04-29" version="1">MTSFITVYQRKSNDGWLKETVHDVLHITPSLHGSSPTHVANAEGDGRNLAAPEDEDAGSFVTARSHSPEQRSSGFQHERTRSFSCFPSAATPNRTVREAGSPSNDSRPPRTPSQAHHMPVCSPSAQQGSRNFRFPRLTASSNSNHRSPPAGHAPTRFLRFGRKRGSIAEKTVEIQASVKAASTIDKALEITDPRDRRLSTVSEFSHFDSHPAVQPLGAQQALDEAACSDDENDLTQYPGLLRLALIVVGICLSVFVISLDRSIITTAIPDITSRFHSSADIGWYGSAYLLTACAFQPLYGRIYVSFATKSSYLIALAVFELGSLVSAISPSSNSLIIGRAIQGLGSAGLLTGAFVVGTHSVRLRYRPILFGAVGILYGVGALCGPLLGGTFADTIGWRWCFWVNLPIGGVTFVTVFLCFKNNSLQVKKSARRSFKSRLLELDIIGNIILLGGTTMLILALQFSEQRYSWSSARCVGLLCGFGATLLIFIAWVLYRGDAALIPPRIVRQRTVAASCVAGFLIYGALLLHSYYLPIWFQAIKGTSAIHSGVNMIPYMVANALFSLLAGIFVSKNGLFAPPAVVGCAIGTVGSGLLATIGPSTPSSRWIGFEVLISAGLGMAIQQGFSAVQALLDVEDVPIGTAAVVASQSFGGAIFVSVGNTLLQNHLLNKKNAASIPGVNIRAALELGATEFRRTVPVKDLPALISLYNDSLRIAFIAAVPLCGAAFICCLCMEWKRLGTAKGAVKDETNNEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQF7</accession>
    <name>A0A0D2BQF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240936.1">
        <property type="nucleotide sequence ID" value="XM_016375660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQF7"/>
    <dbReference type="GeneID" id="27328380"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01297"/>
    <dbReference type="HOGENOM" id="CLU_1065731_0_0_1"/>
    <dbReference type="OrthoDB" id="4117972at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="258" mass="29410" checksum="69B4ABC774FFDB3F" modified="2015-04-29" version="1">MIPWNQFTSSQQDPDWRIELNEHNLLFYVNKGPSQLRRVLDSPMLESAQERQFVLSQLGLPNVNFETEHAGRMGYAIQLFSKHFITHETDESFCPSSPHYEDLTDFRSAFSYAEPTPSLPMSDLLEGLPSPSSPTPTVKSLRSAKSPMSVESLMNPEISPPSERKRKYSDERFPPIDADDDPEGLEALETPASLKQTFKYARTAKIGNAPTARLRRDTRMRRPNLDRGHSKFKYMDGGRHQNDLRGSSSLLDWSQYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQJ5</accession>
    <name>A0A0D2BQJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241474.1">
        <property type="nucleotide sequence ID" value="XM_016376198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQJ5"/>
    <dbReference type="STRING" id="91928.A0A0D2BQJ5"/>
    <dbReference type="GeneID" id="27328921"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01838"/>
    <dbReference type="HOGENOM" id="CLU_094649_0_0_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="203" mass="21561" checksum="E75B0CAD7A511B2E" modified="2015-04-29" version="1">MEKPNTNSLADSFTSPIFSSLAVGVGTGAVGIAYGGVAGTILSTPNPLLYPTYSGLQWFCAGTTFFYCRSILLADPKTRQQPLHVVAASGLSGFGAGAVAGTFLRRTAVIPGGVMLGVLAATSQTVLNMNGGSFELNFNEIPLRLQRGIANLMPMQSLSDKEYEELLTSKLLKIEAQISLLDDQIADLREASQQQNSSRRPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQX4</accession>
    <name>A0A0D2BQX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233780.1">
        <property type="nucleotide sequence ID" value="XM_016383077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQX4"/>
    <dbReference type="GeneID" id="27335835"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08752"/>
    <dbReference type="HOGENOM" id="CLU_107714_1_0_1"/>
    <dbReference type="OrthoDB" id="3468019at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00531">
        <property type="entry name" value="NTF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16767" checksum="58343EFDD0D481D0" modified="2015-04-29" version="1">MGYNTAETEWPSSIELSEAKKDFLDKYFNLLDTNTPTAGAEVADLYTDDGYIMGHAGPVRGHAEIQKSRDNGWSVIKTRCHKLIRVYAFDSSATDLLIIGSAVQGLANGKSVSGEWAARICLDQGAEDSVKIKSHQVWADFGGVLKAIQEALGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR45</accession>
    <name>A0A0D2BR45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233915.1">
        <property type="nucleotide sequence ID" value="XM_016383212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR45"/>
    <dbReference type="STRING" id="91928.A0A0D2BR45"/>
    <dbReference type="GeneID" id="27335973"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08890"/>
    <dbReference type="HOGENOM" id="CLU_044758_0_0_1"/>
    <dbReference type="OrthoDB" id="4218123at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="285" mass="31679" checksum="170F5EE6F79507E7" modified="2015-04-29" version="1">MPTDALFSRFAMLREHGTLTPVDEALRSKFTSPALRQIYLRFGPSTLLNCTFCHADDTFSYLLYHYSINILLPHIFHIFCLGLATSETVSGYESSRWRGQALLCALALAAVDIAVTTTYSPVVSPSIPAPGGIFWVASTLRYLALCLFDAVVAFLIYASATGRFLLFSAPSAADPELARRRMEEAVTKANLSLQLSQTNLRAYTIARNATVRNTTLKASDDDYWRRVVSVEESQGLGDDRGVFEDEEVQAAISRAYGSGSMNVEQMRKEADVYVKNVTRWLDTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BT71</accession>
    <name>A0A0D2BT71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241821.1">
        <property type="nucleotide sequence ID" value="XM_016376545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BT71"/>
    <dbReference type="STRING" id="91928.A0A0D2BT71"/>
    <dbReference type="GeneID" id="27329268"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02185"/>
    <dbReference type="HOGENOM" id="CLU_030267_1_0_1"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="443" mass="48631" checksum="B8BA83482B80B6D7" modified="2015-04-29" version="1">MEPVRQSERSISDPGTKLQRNDSTPNEPRRGKRKVRRTAGAVTQSTSSSEVAQTISLDHCNAQYAAQIYDEPAMIGSNRGSFESSERPTPFPKIEDELSAQEKEQKEGSKPKRLRDGHKRSTSGSVLSRFAFLRTNSDQQDKSDSVDRDGSDTITHAHGRGAMAEAQAQTKRKRKGSLRKTVLGKGRDRKNSDKKSPLSSTPDSATLTKTTTRSPGDAEAPALLTPRASQEPSSSPASPDSPPWSFRTLSRVSIPSIRSSIASIEPASSATSITSPTMPTDASTDDEELVLPPRMSALRKMPSSTSSSFGDSYFPIQDPVRRMFASRTRSPLATQPQSIAGTPPEEEGWDYSETAFWGYVILVVTWIVFVVGMGSCFDIWSWAWDVGETPYAPPELEDDPTLPIVGYYPALLVLTCVMAWVWVVVAWVGMKYFRHADFKGDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BTN9</accession>
    <name>A0A0D2BTN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234815.1">
        <property type="nucleotide sequence ID" value="XM_016381713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BTN9"/>
    <dbReference type="STRING" id="91928.A0A0D2BTN9"/>
    <dbReference type="GeneID" id="27334466"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07383"/>
    <dbReference type="HOGENOM" id="CLU_005679_13_6_1"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="96"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="525" mass="59622" checksum="49BFA0C3CDB6945E" modified="2015-04-29" version="1">MSRIVSEMEEQGIPLLNGSDHNGTSSKTSFEAEQRGIPDTTNGGYEHATPQSISLPSQSKKTWLSSWSIDPWAVVPRYVQPGGRKKYEQRRSPTSYLDALRGYAAVFVYIYHFWDLPEPSFFHWPLIRVPWVGGAGMVAVFFVISGYVLSYRLVKLIRMQESARLLDSLASSIFRRYLRLYLSTAFATHLSAWCIYFGWLLGPFTDLRLSSLPAQLWAWFQDTIATSNPFANIEGWIHDGVFFPHYLGQMWTIPVEYRGSIIIFVFCAAACKMTTRCRMVFAWIIIALSYYWRVAYVVEFVFGTFLAELSLVLHPERHGLQNPSLAPAFASANTNATTATNDTINEKHNQRNGSGEIPPPSPRALTRVTSYLLLAIGLFLLGQPDPPALGSTGPWPWQYLYRVIPSWYGDAAYTFWPSIAACCSVLAIDLNPTLQRPFEWSFSQYIGDLSFGMYAMHVILLYSVYQQTILVWQVTYLGDSTLAFLPGALAITLLLIWVADYFARVDKIIVHFGRWLQAKSFVKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BTV9</accession>
    <name>A0A0D2BTV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphogluconate dehydrogenase NAD-binding putative C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234915.1">
        <property type="nucleotide sequence ID" value="XM_016381813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BTV9"/>
    <dbReference type="STRING" id="91928.A0A0D2BTV9"/>
    <dbReference type="GeneID" id="27334566"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07483"/>
    <dbReference type="HOGENOM" id="CLU_052530_0_1_1"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="2">
        <location>
            <begin position="245"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="39990" checksum="3255B90D6081D75F" modified="2015-04-29" version="1">MATSSASPKPNVGILSIGDMGVGIARLLRHHHYKVYTVGAGRSQHTLNRIKSAQIKALDSDEALVAESDIILSIVPPRDAVATAQRAHQACNAHAAIKRRQERTGIARKLTFIDLNAISPRTTKSIGALFSSPQLPSSPGVQGITRSFSFHRSDSEPELPPIEIDFFDGGIIGGPPSLREDQTWKRPSIVLSGPRLSEVLPSEFTELLNVRVVGNTIGPASALKACFASLSKGMIALSILSFTTAHQAGVLPALEEHLKEFNPGALAAAKSGLTGMPPKAYRWVDEMRQINETFMEEGGFGKDVLGETHGVFDGIAEVYKLIADDTVLGEERVESRKRGTEVSDVVECIGEGIKAKKRKIAGEDWRRNWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BV76</accession>
    <name>A0A0D2BV76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_05199</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235370.1">
        <property type="nucleotide sequence ID" value="XM_016379543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BV76"/>
    <dbReference type="STRING" id="91928.A0A0D2BV76"/>
    <dbReference type="GeneID" id="27332282"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05199"/>
    <dbReference type="HOGENOM" id="CLU_104368_2_0_1"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW15154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="153" mass="17085" checksum="2AC29FEBFF98D700" modified="2015-04-29" version="1">MPSNLPYAADAESPLKPAELQVLRAQYEKEGDYVGVQTKFNYAWGLIKSNQRSEQQLGVQLLSDIFKTTPERRRECLYYLALGNYKLGNYAEARRYNDLLLEKEPGNLQASSLRQLIDDKVSKEGLMGIAIVGGVAVAAGILGSMIMRGSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVJ6</accession>
    <name>A0A0D2BVJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235525.1">
        <property type="nucleotide sequence ID" value="XM_016379698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVJ6"/>
    <dbReference type="STRING" id="91928.A0A0D2BVJ6"/>
    <dbReference type="GeneID" id="27332437"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05354"/>
    <dbReference type="HOGENOM" id="CLU_002639_5_3_1"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="62"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="531" mass="59932" checksum="3CB5760D43CC206A" modified="2015-04-29" version="1">MDASVVAKVKEWIGHCLTTHLACRALVPRQVRYPTRLLDVRAWHQTGILNIIQVPKGFDSDYVALSYCWGKKDDWWIQYVEASQQGGWEIEGDKMPQTYQDAVAACIALGYSYLWVDCLCIKQGDMDDWLTESAKMSDVYTNAILVISASDAVSCGAGFLQDRPPLQRDGAVMHILDDDGTVGLARLCPPNTDFQTLVGDGPVAQRAWCLQERQLAPRVLHICQAEVFFECVRCRRYESEKIPGAEFDTSDESGYHFNIPDRNFHSEAKGKPPGNVVDVLSWFVIVQDYANRSLFDAGDKLIAIAGLARRAHDIIKGDYLAGIWRKYVHFGLAWMVENTAIATRAPESPYRAPSWSWASMDGPVTWKDLGHDMIAKSDYVKTAMDIMDTTVRLAASDPFGAVLHAELIVSGQLRTASSDMLLHNEVLHYQIWERESRYWPPSIRGWYLEDEKRPWKNEERICLNIMTREVFGNSEELVHTVLLLEIAQGPNSDGAHGDGLDNIKTYKRVGYGEIMAADFFDDCPAQRLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BX62</accession>
    <name>A0A0D2BX62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236105.1">
        <property type="nucleotide sequence ID" value="XM_016380278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BX62"/>
    <dbReference type="STRING" id="91928.A0A0D2BX62"/>
    <dbReference type="GeneID" id="27333022"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05939"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="492" mass="53113" checksum="0279107C0C680204" modified="2015-04-29" version="1">MAEVSLEGLNNHIIRVPTGLFIDNEFVPATGNATLDLENPATAQHLATVSCAQEQDIDRAVQSSQKAFVSWKSALPSTRRQLLSKLADLLERDASDVSTLESLDAGILYNDSTRLNIPQALENLRYFSGWADKVDGMALAIPEGMAYTRREPYGVCAAIVPWNSPLMITIWKLAPCIAAGNTLIIKTPELCPLYGQKLAELVREAGFPPGVINIVCGLGPVAGQRLAEHPVVRKISFTGSPAVGRQILATSARTNLKKVTLELGGKGPSLVFDDADFENALFWTTIGITANNGQICVAGSRIYVQDTIYDKFVQEFSRRSREAVHGDPLLATTTKGPIISARQRDNVLSFVDQGRQAGAKLLHGGEKLPGAGHFIANTAFSDVPQDASIMQQEIFGPFASISSFKTEEEAIAKANDTSYGLSAAVFTSNLDRAFKVTEAIEAGQVTVNIWGTVNANTPFGGVKESGFGRDMGKEALDEWTVPKVVKWYIQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXC0</accession>
    <name>A0A0D2BXC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236150.1">
        <property type="nucleotide sequence ID" value="XM_016380323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BXC0"/>
    <dbReference type="STRING" id="91928.A0A0D2BXC0"/>
    <dbReference type="GeneID" id="27333067"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05984"/>
    <dbReference type="HOGENOM" id="CLU_021434_2_1_1"/>
    <dbReference type="OrthoDB" id="205108at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF10">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="388" mass="44469" checksum="E8F823317D2B2027" modified="2015-04-29" version="1">MQFAIPPRKTSQPPLHARTNTAASAAYGRRKQLQLLGYVVLGLLTFYLTLRFCLWRGTEDAEDGSAAIEGRQDVVLVTVFDSKTMSEDYMKIVKLNREDYAARHGYKTFYTNVSGYSTLVDPAPSSWTVIPALRHALTDHRSSDWFWQLSPDALITNPSLSLESHILQPLDSLMLKDLPVVPPDSVIHTFSHLKPSRTHLILSQDMDNLAHTSFLLRNTPFTPSTPDNWAQYFLDAWFDPLYRAYSFQKAENHALEHIVQWHPTILAKLVLIEQRRFNSYNYATPPVRDGDGNLRTHDSMWQEGDFVVNLKGCRESDKRDCEEELRHYFAMWEKEVEKLDGKRPEHDIGPAKPKPQPKEEQPKPQPKEERPKPQPKEGQPQAEPAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BYB0</accession>
    <name>A0A0D2BYB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236520.1">
        <property type="nucleotide sequence ID" value="XM_016380693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BYB0"/>
    <dbReference type="STRING" id="91928.A0A0D2BYB0"/>
    <dbReference type="GeneID" id="27333438"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06355"/>
    <dbReference type="HOGENOM" id="CLU_602745_0_0_1"/>
    <dbReference type="OrthoDB" id="4161551at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239334" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="48943" checksum="36FCE34E85BE637B" modified="2015-04-29" version="1">MRSTLVSSAVVVGLATFISTSAAKPYVAADELDSLEPFPWADWADWSDWGDDSDGDDIITSTKVSTTSTKVYTTSVIPTPSVDHRTDPTCPYANTQPFGSRQSDCVSYDYVCGQTYDDSDDFLDYSIGTLSPEECANQCDELNSDHPGRCVGVVFDLEMDTDNCKFLTSTSVPQTDDHVVALIRHYTPGCHATSTMKSTTVVTTTWIAPFESSTTAAYTTTTGETAIEFTTTTFKWTRTPTSTPADETTTSSTVAETSTKVAETSTTSAETWATTMRWSTTMEDTSTTPTISMTSTTVVVGAVTTSSEYPTTSSPARETTSTTTWESTTTSETTTTSEGTPSESSTTSERSTSETETWTTTGTWSTETTTSATSSESTTTVPLSTTLSSATETSRPTSTLIQSTTSSSCRATTIYVTPEPRAAIVTTVTATEYHTKIKKVCGMPSVNRHRWHWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C1Q4</accession>
    <name>A0A0D2C1Q4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CAF1B/HIR1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04779</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237800.1">
        <property type="nucleotide sequence ID" value="XM_016379123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C1Q4"/>
    <dbReference type="STRING" id="91928.A0A0D2C1Q4"/>
    <dbReference type="GeneID" id="27331862"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04779"/>
    <dbReference type="HOGENOM" id="CLU_010127_3_1_1"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000461">
        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="309"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="203"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="431"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="563"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="646"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="665"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="726" mass="77019" checksum="9478259D0C9C85DF" modified="2015-04-29" version="1">MKAGPLLITWHNDNQPIYSVHFDPRGKGRLATAGNDNNVRLWSIEASGEERKVTYLSTLTRHTQPVNVVRFCPKGEMLASAGDDGNVLLWVPSESAITTLSEEHADDKETWRIKHMCRTSSGAEIYDLAWSPDGQYFITGGVDNTARIFNAHTGAMIRQIAEHNHFVQGVAWDPLNEFVATQSSDRSVHIYALKLKDGTPTLSTHGKFNKMDLPARRISSNSPAPVELSHRASNASANNLSIASPAPSNPGTPLATPLPMDPPMITSSRRSSFGSSPSFRRSASPAPSLPLPAVRPEISSPSLSAAMGLAVKNTNIYHNETLTSFFRRLSFSPDGSLLFTPAGHYKQAFPGAGDPVKPTEDISNTVYIYTRAGFNKPPIAHLPGHKKPSVAVKCSPVLYTLRSATKPTNHITIDTSSASEEIPLLPEAITAPTPTSIMEPPSLSTATSAPESMSAPSPKPATDTDSSSSSVFALPYRMVYAVATQDAVFVYDTQQLTPICVVSNLHYATFSDLTWSNDGLTLLMSSTDGYCSTLAFSPGELGQVYTGPHPTYNHPVVSTSIPLPTSSAGSTPMPTPTATASPSLTKASPVQGPLSHQSPAPFVLRPGSPARSNSQSSIATMASIQTTSLQNNPTPTMGHVPLVTATNSGPPVAIPPMSTPPQTPASAHGGHHSATSSISGSVLGKRDVSATSESEKEENKTKKRRIAPTLVGPSGSSEASKEDGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C1V2</accession>
    <name>A0A0D2C1V2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237845.1">
        <property type="nucleotide sequence ID" value="XM_016379168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C1V2"/>
    <dbReference type="STRING" id="91928.A0A0D2C1V2"/>
    <dbReference type="GeneID" id="27331907"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04824"/>
    <dbReference type="HOGENOM" id="CLU_103791_1_0_1"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="18"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="157" mass="18457" checksum="62718194F0EC4062" modified="2015-04-29" version="1">MALNNYIDAENAPNYEDMEKQFAVKAVQQMTVYWSLLEKIPGSKLRLTRLDDQILEHFKSEFPEFDPAEEIDEDKMKSKEGKERWRKFAMAYEKGDNKIDDFNFGTMLRKSPKTEYGEKETIFAVRMQFYAIEIARNRAGLNDWIYESAQKDAGNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3C2</accession>
    <name>A0A0D2C3C2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238325.1">
        <property type="nucleotide sequence ID" value="XM_016376755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3C2"/>
    <dbReference type="STRING" id="91928.A0A0D2C3C2"/>
    <dbReference type="GeneID" id="27329479"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02396"/>
    <dbReference type="HOGENOM" id="CLU_021599_2_1_1"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60238" checksum="6D37F58AC6D29462" modified="2015-04-29" version="1">MTDIWCNVDSVIVRNPSAANVQSHGGCASERLSIDNDVFYGVVRNDQRLHYESSRSPAATHEERVLNTVQMSPATVYRRQILATYINATVPFDFLQPHDLPWLRLFYHIENWPVCLEYAVLAVGLAALGRKAGDSSMVSSSTRYYVHGLRGLRMALTRPELAAQDGVLAAGMLLASYEIVEGPEPSSRVAYIYHHQGCGRLIKFRGPEAHSSGTGHAIFRTYRIEGLLAALQPPHDTFLLERDWLSIPWSGSPKLWLDRVMDLLGSAPAIFRQVQTFQQNMSQVGDLVPTARRVLRQCLELERRMDEFFKGFSNGKTRPFYWPMLSRLKIPDASSVCYEFSDLTTAKILMFYWATLTMLRSGISSLGDMLRSVSRGGGAGVVVDVRGGAEGNQIQDPNPNPDRHPHRHRQRRTSFDLERDDDIVERSRRTTATTTITITTPDPPRRDLDVLVGREHGSHATVDVRTPARNVLQSVEYCLQRDMLGLGPVIAVAPVMMVLETLDRRGGNEFHTECEWARHILRIISTDRLCGLRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C7T2</accession>
    <name>A0A0D2C7T2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239850.1">
        <property type="nucleotide sequence ID" value="XM_016374574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C7T2"/>
    <dbReference type="STRING" id="91928.A0A0D2C7T2"/>
    <dbReference type="GeneID" id="27327290"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00207"/>
    <dbReference type="HOGENOM" id="CLU_003115_0_0_1"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="675"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="505"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="717"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="735"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="805" mass="86666" checksum="51EFFF0B085739DE" modified="2015-04-29" version="1">MAGLSVGDTVLVPGDMHGTVKFIGRVDGKKGIFAGVQLATEYAPRGKNSGDVDGRFYFKTAIPGSGIFLPVEKAVKKTMGLGVRASPGPGTPTRLSSFNQGGRTPGTGIAKPNFSQSIGPGVRAGAASPALKPPVRRESLPRPSSPLRKTATPTGKALATPKTRPSGIGMGLGKSTNGGTGYRPGTGRPTTTFSQNLRHSTTTPSVESGTSPSLGPESSFDEGSGEGQNTPTPTPHANRGVDVEQYEKKIRELNEELSVARRQLRDQGANFAEMESSFNELQKLLPNLEASKRNGEEDDDDLPRDVAELREIVREKNDKIKMLTAEFDINRADFRSTIDTLEMASTETERVYEKRVDELLEEVRNLQDRSEDVESVAQQLKQLEELVQELEEGLEDARRGEAEARGEVEFLRGEVERSRSELRRERERLKTEEQLNGYSAGDVEDLKAQLSAKDDEIRGLKAIIQSLNETHDKSPKMNGSKPNGLSTRKEKPSDDADGEENRLSLRQQIRDLEMLLQQKSAHEEELANEVKHLRNSVALSKFPMPGSAFGLHTSVRSLPGGHSRGNSEDMDRKHLSTGTTGSQRTVVLGRSSAPQGNVHDWQDVNRRSASPLKHDQMDDAVTDISSSSAPLWCEICEEGGHDILTCSNMFGPGKSSNSQGSLGKRSGKDVVREGLRRSGDQSQILSGADSDRPAPLVSRKANNNATTSTAGASIVTSPPPTGTLPPPPSLPLPHALEDDKPPTPPAKDDTPASSAPVPASAIEGTGIQAGMLAGRTSGVIDPEKWCALCERDGHDSVDCPLEDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAR9</accession>
    <name>A0A0D2CAR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240890.1">
        <property type="nucleotide sequence ID" value="XM_016375614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CAR9"/>
    <dbReference type="STRING" id="91928.A0A0D2CAR9"/>
    <dbReference type="GeneID" id="27328334"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01251"/>
    <dbReference type="HOGENOM" id="CLU_046871_3_0_1"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="139"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="263" mass="28714" checksum="18E3B5A9483F54A0" modified="2015-04-29" version="1">MEASDPKMSAANNKRKRLPGDQGLGRDAKAQNTNGDHQDYAALLQGLDAVSGADDSTRTAQAALAAPMNSSAYPEPPSFEGAAALSSAFDENSPPAMPTMGNMNNMGNNIGGLPHNNIHGGRGSQSEKPAVGSAEWHQQRKDNHKEVERRRREVINEGIENIAKIVPCTEKNKGAILQRTHEYIIALQTKEAQFETERATFDVALKELTNRLDRMKESARAAWAESNKWQQRARDAGLHFDDYDEANLTGFEEDDVAAADVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CB17</accession>
    <name>A0A0D2CB17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_01342</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240980.1">
        <property type="nucleotide sequence ID" value="XM_016375704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CB17"/>
    <dbReference type="STRING" id="91928.A0A0D2CB17"/>
    <dbReference type="GeneID" id="27328425"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01342"/>
    <dbReference type="HOGENOM" id="CLU_010510_0_1_1"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="215"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="323"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="890"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="907"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW20764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1005" mass="110628" checksum="C731E11DA5D13C90" modified="2015-04-29" version="1">MPRVSSQSGGRPSRQAVVMNMAREKSKASPIKLALNDDRGEKVARLQSRQALQEIHMNEIRAAASPVRKINQHRNRDRRDTSGSRAMSESPRTPRTSDAHLRKKVALHRRQSQQNHGQHANSPRTDTLTPMKRVPILANFEEWMKMATDNKINAANSWNFALIDYFHDMSLLKEGDGVNFQKASCTLDGCVKIYTSRVDSVATETGRLLSGLADGAEGKKRNKDDGADDDDDEGEEGEDGEGEDGEGKKKSKKKTTRSHEATLAPGFASFQGKKLELEFAVDPLFKKASADFDEGGAKGLLLNHLSIDSDGRIVFDSSDDAGDATLVADKDKSQHHGDGDQEDGADAAVAQATKAAAETDEAEMEDPTPTPEAEEQDEEIDLGALAAKFFPDLGVLDSQDVCPSMKSFTLGDPSGELNIPFLKAPDDWREQKKGSTTPAPPTLDGNINLSDQTGIFLDGTNAMGFDDDDDDGGLLGGFDVADNVGFGEGGEAWAKDAAIEAQTRVVQAGEMDDNLLEGDNNAYALSLQHKYQEDAEHESIMAYFDKAFNSRAKGKMAFMTLENWRMQKIQKAAQAENAPTTRQRKEKEPFEIDFLGPMSESLKELLEAPAVLNSQISLPKGQWKTKGRNLLDKDDEVVDPRKLMRLWTKPKCRVGRRKGKMGVIDEGFGARNRLAIIHGQQGDVDEDEEDEGRKGDYDADFFADDDQMPFFDGPLPIDDEDDGLGVGDLDVGDEGQAFMDAREMLSPPPPDGQHQRQNDGFMGMMEDGAVLKQEPQEGAETQDPQAQHNGLDLLPGSFGSQLVTQAGRRLRPEYVNYARTAKKVDVRRLKENMWKGMSEKLALMRIDVFEKPTSVQQEHAQQRQQQVSEATANGVVDEDVDMMDVDVDMDEHETSQDQDQLQGELQRQVDDADATRGDEGVGGGGAGQVGEADDALKFTELIQDLRGVYPEQQMKDISTSYCFICLLHLANEKGLVLEGEVDGERAMQEIRVMRDKSVGEGYEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y4Q1</accession>
    <name>A0A0D1Y4Q1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230122.1">
        <property type="nucleotide sequence ID" value="XM_016385990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y4Q1"/>
    <dbReference type="STRING" id="91928.A0A0D1Y4Q1"/>
    <dbReference type="GeneID" id="27338765"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11682"/>
    <dbReference type="HOGENOM" id="CLU_012494_6_2_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF557">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C1039.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="116"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="364" mass="40566" checksum="B3AB0ACF5AF794DE" modified="2015-04-29" version="1">MTISSIPQTNGGPTTEKYENGALPNAIHPDFLPRLDEDFVQYYNKYFAWKPPTHEINVREIRSNPTKYNSPWERDYTGSSHIQDMQLLSHDGYEFKVRCYHPDAVKFGDGPYPLHVNFHGGGFVFGGLKGDAELCKLIQENVGVLVLDVDYRLMPEHTFGDGHEDAWAVVRWLRDHSQDINGDRDSISVGGISAGGAIAAVIQQLARDEDIPLKLAFLAVPTTQSFGDLTSPLKSPYPSIAENALAPCLNWARLAYFRDVAFPRDPRALEAIAALPEFYRSPINGNMKGLCPTFVATAELDPLRDEGEAYAEKLVEAGVKVTVRRYTGVPHPFMHMTPIQKAALYAEDYCEAVRSAHRKVDVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y625</accession>
    <name>A0A0D1Y625_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230567.1">
        <property type="nucleotide sequence ID" value="XM_016385623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y625"/>
    <dbReference type="STRING" id="91928.A0A0D1Y625"/>
    <dbReference type="GeneID" id="27338396"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11313"/>
    <dbReference type="HOGENOM" id="CLU_826396_0_0_1"/>
    <dbReference type="OrthoDB" id="4154548at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="33863" checksum="445A8B0458B156C5" modified="2015-04-29" version="1">MPTATTDTDGTAASPTSAATDTDKPNAVVLYPTGQPTVNNIDTVEVAYDTIWENASLTLFCDIDEADNKWSLANISLLQPSGKSAISPIQAGMQIPQFPVSCGILIYDESNRGDSTTGGGFTMTSTTGIVSTYGLSMTTARDMSKMTTGTKNSAATDTNVSSHSTIDSSITKDTAAVSSSTATNTDVLGAADSSSSPSSPSHSTGLGAGARAGLAIGIILGAIALSAALFFFFRLRRRIARVENMVKGGGTASTEKVLASSSPPLPPALAPQIAKPAPLPTFTARSNSPAALTPGAGGGDGNGSNNNTRNSEEWRQFFGNASNPRSHTSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y822</accession>
    <name>A0A0D1Y822_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231312.1">
        <property type="nucleotide sequence ID" value="XM_016384710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y822"/>
    <dbReference type="STRING" id="91928.A0A0D1Y822"/>
    <dbReference type="GeneID" id="27337478"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10395"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_2_1"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="134" mass="14385" checksum="F7C6C9CBF085A634" modified="2015-04-29" version="1">MAPKQPVNSDKGLKSPLFSQAIVHNGTVYCSGNVGIDPVTSKMVEGSVADRTKQIFENIKNVLEEAGSSLQNILKMNIYLVDMGDYAAVNTVYLDTIPDPKPARTCVCVKELPGKTDVEIECIALLNDAAGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y862</accession>
    <name>A0A0D1Y862_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10466</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231382.1">
        <property type="nucleotide sequence ID" value="XM_016384780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y862"/>
    <dbReference type="STRING" id="91928.A0A0D1Y862"/>
    <dbReference type="GeneID" id="27337549"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10466"/>
    <dbReference type="HOGENOM" id="CLU_013260_0_0_1"/>
    <dbReference type="OrthoDB" id="3014581at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW11166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="720" mass="80653" checksum="7E59F1490614608B" modified="2015-04-29" version="1">MPPEVSTPSANPLKRPRQDPVSCQFCRSKKLKCDRQQPCSNCTTRGLPCNGQAQPRRENGSPSAEIDNLSILARLKRLEDIVMGSPKQDPAIPTDPLSGLPSRPSSTFACLSPPSEYEEAVHNLEEAGTRETHWPTLGASDIEFQILGTKEMASTPGVTQGVTSKRPNYQMPVKCVMLPPKEEADMLLEYYVKHVDDLQHVVFVSHLRTLMEKFYANLHQRLSIAYGQLALLLTVFASSAAMFSHVSCNKVAQFPPSSAAHASLVWANSALQVMGCPRRTAAGGLEEVQAAILMAFLLYHVEGFSARSRRLLAGALSTARDMGLHKLDATSGPSSNSLRAADPVDLEIQRRVWWHVVSTDWLLGLCGGPQEGTYFIHPRQFRVNLPLNINDSDLVYGRPLVGRPSSEPTTMSYYIQRIKLADICRSVIDVMPLFSVSVTSIDYQQIIELDGKFEAFLNDLPTFFKVDEKSRRESEAITRKNSYIKVQRYSLGMVARTRRCKLHQPFLIRRSVESHYTYSREISLTSARCVIQLRRMAEEEFDSTALAHAKMTGVVYHVFMATIVLVMDLCFNRSEGDDDKRKAEVTEACTILEEAAGQSSLAREFLDSLMDILRKHKVHLHPIHPEAASKTKIKQTPSQNAPSFAVPQAEVLHNFFPAQDTGRNYMSDFDSIWEDYIQLGPNMDMPEWDNLFADLDSRFTDSETVRRAPDLSHNVPGNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YBB4</accession>
    <name>A0A0D1YBB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232437.1">
        <property type="nucleotide sequence ID" value="XM_016383814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YBB4"/>
    <dbReference type="GeneID" id="27336580"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09497"/>
    <dbReference type="HOGENOM" id="CLU_1525173_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="176" mass="19531" checksum="212C0D4D9F0083E9" modified="2015-04-29" version="1">MAGQHRSLELRSRRLRESNDGVLYNADDGHPFDIPSPDTILQTPERSPSPEETAHEPMPDTPSDTSVTETSKPQDKPEEPEMDPRNSSSKKPQPAPRSTTSSSREQQRPSQSPQRADRANDRTSEERSTASLAGVLANRGEALPLTMFSGLVDASPELDKKRESELTWVEEEPQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJG1</accession>
    <name>A0A0D1YJG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)H dehydrogenase (quinone) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235317.1">
        <property type="nucleotide sequence ID" value="XM_016382215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJG1"/>
    <dbReference type="STRING" id="91928.A0A0D1YJG1"/>
    <dbReference type="GeneID" id="27334971"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07888"/>
    <dbReference type="HOGENOM" id="CLU_058643_2_1_1"/>
    <dbReference type="OrthoDB" id="26889at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051545">
        <property type="entry name" value="NAD(P)H_dehydrogenase_qn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204">
        <property type="entry name" value="NAD P H OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204:SF34">
        <property type="entry name" value="NAD(P)H DEHYDROGENASE [QUINONE] 1 ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like fold" evidence="3">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="266" mass="29833" checksum="14448B09CE250CF3" modified="2015-04-29" version="1">MRVLVVLAHPEPQSLNVALSKVIAEELQTGGHEVQVSDLYAMGWKSNIDRADFPTFPKDKPLAIAKASQLAYTAAHLTEDVMAEQKKLLWADTVILQFPLWWFSMPAILKGYVDRVWSCGFAYGVGEHSDKRYGDRYGEGVFAGKRAMLVVTAGGWESHYSARGINGPIDDLLWPINHGILYYPGFTVLPAFVAFRVDRYDKAAFDATADRLRERIRTLSATDPIPFRPQNMGDYEIPAMVLRDDIQSEGQEGFKLHQAPSSEKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJU9</accession>
    <name>A0A0D1YJU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235472.1">
        <property type="nucleotide sequence ID" value="XM_016379645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJU9"/>
    <dbReference type="STRING" id="91928.A0A0D1YJU9"/>
    <dbReference type="GeneID" id="27332384"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05301"/>
    <dbReference type="HOGENOM" id="CLU_030130_6_2_1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF2">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="375" mass="40960" checksum="85AD18BC13069C97" modified="2015-04-29" version="1">MALPRFKAAACHLASVFGSARQTTDKTIGFMRKAAQNSAQLVVFPESSIPGFPYWSSIIAPATGHDFFRYMAEESVYVDGEEIKAIQQAALQSRIVISLGFSEKVRYSSATLFNSNLIIGDDGQILVHHRKLMPTFFEKLTWSPGDGHGLRVADTRLGKIGALICGENTNPLARYALMAQGEQVHISSWPAIWPTRLPLDGEPTPATGNYDNVNANTIRAAAHCFEAKCFGIQSAGVLDHASIQGIAQMTSDPRRTTKILSTYPQATTQFLDPNGHLIKSRIVWPSSDVQDEGLCLQNEEGVLIADIDLNKCVEGKQYHDVVGGYQRLDVFNLQVNRNRHEPVVFASGKKTEHDPPETASCSGSKSTKDSGGIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKH0</accession>
    <name>A0A0D1YKH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235687.1">
        <property type="nucleotide sequence ID" value="XM_016379860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKH0"/>
    <dbReference type="GeneID" id="27332600"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05517"/>
    <dbReference type="HOGENOM" id="CLU_030730_1_0_1"/>
    <dbReference type="OrthoDB" id="4121291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="396" mass="44434" checksum="095E6E6DE92AA9E1" modified="2015-04-29" version="1">MLGWKPPPGHLSPHRLCDEIRYETPEPTFSPSPPSASLSKDFACEGDESMPPRSYQTRRRTIISDSEPDSVSGVSRHRVHENNHQSDPHVEIKSLRGRARVARGASSSTCATPGSRHTRVSQPTDATSYKSPGFLRTPHTPEPRSGSRDRRRLSSREQSVTVSACSDTREEQEEANYDVAAFQAELYSSRSLRKRTVQQTNPYKFDKYQHTISRRTGQSPDPEDVEEAVNEEIEMTQARLSSKKQSKASNAGTKRKRKTPALKRNGKRRHLEPTLSTTDEESRVTSFDPAKVTLKVWLDGFPAASAPTTLLACGDVDRLFDFIVESWGWSVEGASIRYAIISFPWLDEESNILLRPGMRDSFTRMVSEVEKAECWKSGGNEAACEIKITVFMESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YP73</accession>
    <name>A0A0D1YP73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-fructofuranosidase</fullName>
            <ecNumber evidence="2">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="2"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237172.1">
        <property type="nucleotide sequence ID" value="XM_016378495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YP73"/>
    <dbReference type="STRING" id="91928.A0A0D1YP73"/>
    <dbReference type="GeneID" id="27331230"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04147"/>
    <dbReference type="HOGENOM" id="CLU_042071_0_0_1"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08995">
        <property type="entry name" value="GH32_EcAec43-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="29"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="489" mass="54596" checksum="6A7E14F2D8A75811" modified="2015-04-29" version="1">MSQPKVAVSMNPLHVRDPEVDGPQGDAIPFFYDGKYHLFYLEAPALKYDQPDRGRTPWRHIVSDNLVDWHDLGIALPLGTGDDPDVDGIWTGSIIAVDGVLHVFYTGGRRAASIPQTICHATSTDGVVFKKSPSNPIHFPRSDWFEQRDWRDPFVFWNKEHKQYWMLVTARAREGPLGRRGVIALSTSDDLVTWTTVREPFYAPGSTYSMECPEVFRLGGKWRLVFSRFTEHAATVYREAEDLSGPWRTPKYPAFDGAHWYAAKSLEDAQGRRIAFGWVHDRRGFTEGGEWLWGGDMCLPREIFVGEDDRLCVRMPSEVDDQFMSERPLLIRQASGSTTAEWEANVAGGFSVAQIETGALPCALTRLSVEADIQDLAGGVGLALYSNPGLTEGLLLFFDASTGAVSLGGPTGGQEDDRLPVPAVTNRIRGRSHGKLQIDLYLRGDVLEIFVDRQVALSYRQYFDRPFTAKPYVEDGVVTFTAKLATRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSB7</accession>
    <name>A0A0D1YSB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238352.1">
        <property type="nucleotide sequence ID" value="XM_016376782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YSB7"/>
    <dbReference type="STRING" id="91928.A0A0D1YSB7"/>
    <dbReference type="GeneID" id="27329507"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02424"/>
    <dbReference type="HOGENOM" id="CLU_025521_1_1_1"/>
    <dbReference type="OrthoDB" id="5396681at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="2">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="399" mass="45262" checksum="8C702819373E0F02" modified="2015-04-29" version="1">MASTQTCSLQITKRMLVRIFTHHQVPMQHMNLLFLFGRENRMTGGRYDSFWGQVAFGQPMPGLEAPDLGRSGKHYEISFNLKGISSDITDPKTFTPEFPHNGAICNVAIYHKLDIIHGTSIWIITKPGGGLSRYTGAEASGSGGDDTRMFTTPAECYISSLEVHITLARWAGESWWAYFQDLETLIEDRTGPAVLADSKETYTAADLKLLQAYLEKASEAVAVLHTNLRILQPLVMFYNKLLGHNQFSLAQDVRQATEDFTYQLQDIKCDFEGQVSRGMHLTAFVRARKELILELMQAHTSDRTMQLSQTSVRESFFMRIVTVVTLLYLPATFVSTLFSREIIRYEENSDEMSSRFSYAAFWRWIQIGLPLTTFTLVATIVAFRRSLRSRRGGPRGYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YU38</accession>
    <name>A0A0D1YU38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238992.1">
        <property type="nucleotide sequence ID" value="XM_016377422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YU38"/>
    <dbReference type="GeneID" id="27330148"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03065"/>
    <dbReference type="HOGENOM" id="CLU_013985_6_2_1"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050276">
        <property type="entry name" value="MshD_Acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43617">
        <property type="entry name" value="L-AMINO ACID N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="205" mass="23048" checksum="8C4A26C5C71E089D" modified="2015-04-29" version="1">MPSFSIQALPRASQDDQDIEFASRLKQLRLKTLQEDPGSWISTYKDEVDQPQDFWLSRLRDPRAIHLVIVRLEASKSEVEDTTEVLSQGDWVGLVVIITPEVHQEDNVSQYGEPSSELLMAAVSVRAEYRGLGLGGRLVEKAIETSRTFAEKRKMTSPSLTAYVRSGNDLALKLYQKLGFKVIQTDYQGEKGGLLYTSTVVRVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUD5</accession>
    <name>A0A0D1YUD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239082.1">
        <property type="nucleotide sequence ID" value="XM_016377512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUD5"/>
    <dbReference type="STRING" id="91928.A0A0D1YUD5"/>
    <dbReference type="GeneID" id="27330238"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03155"/>
    <dbReference type="HOGENOM" id="CLU_036234_1_1_1"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12293">
        <property type="entry name" value="dRRM_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12950">
        <property type="entry name" value="RRP7_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="183"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33448" checksum="7C9B346A36124B52" modified="2015-04-29" version="1">MGPPREVGGCVALPLKLPSVEGLPENVLHYLYVKPHDPKISDDDAQRSLFLVNIPISTTTQALRHLFTTQLEGGRVEAVHFSETVPGKSAAGPMSSRKRKRMTAEELEAGLDAYSLPKAFDSEIHQTGSTAIVVFVDRASMQLALKGAKRAAKSGAALEWNSSTTRGVPRLGMTRYSHHKHLQYPSRKELLRSVNGFMTAYAQMEEARSRENARKRQEPDEDGFITVTRASRGAVRSDEAKALAERQKEKNKGLEDFYRFQMREKRKEEHAEMLKKFEEDKRKVEEMRQRRAKPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUU5</accession>
    <name>A0A0D1YUU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Purine-cytosine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_03306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239232.1">
        <property type="nucleotide sequence ID" value="XM_016377662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUU5"/>
    <dbReference type="STRING" id="91928.A0A0D1YUU5"/>
    <dbReference type="GeneID" id="27330389"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03306"/>
    <dbReference type="HOGENOM" id="CLU_026016_2_2_1"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11484">
        <property type="entry name" value="SLC-NCS1sbd_CobB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="56976" checksum="B03ABA43E64F39A9" modified="2015-04-29" version="1">MAVSYEKSGYDLEYQPEQIPTGGKHRSVVAPDASGAVHGESFVAGDTLYAKLQRLAGRFGVEQRGIERVPEDERTDKSTLKVGTMWLAANMVVSSFAIGVLAVPVFALGFVDSFLAILFFNLLGILPVCFFSTFGPKFGMRQMILSRFWFGYYGVKVIAIFNCLACLGWSSVNVIVGSQLIHAVNPDVPGYAGIIIIAACTFLVTLFGYKVVHMYEMISWVPCFIIFLIVLGEFAHHGSFENLPMGSGAGETGSILSFGASVFGFATGWSSYASDYTCYQPVTTSRLKVFIYVFIGLFFPLMFTEALGLAIATATVNDPAFASAYEANAVGGLLHQVLVPPLGGFGKFCLIILALSIVGNNCPNIYSLTFSLQILTHYAQKVPRFLWTFVGTLVYVAIAIPGYSHFEDVLEDFMLIIGYWLAIYTAISLPEHFLFKKGFKGYTPEHYDQPKCLPPSFAALGAFCFGIVGAVMGMAQVWYIGPIGKLIGTGYGGDIGFELAFGFAASTYLVFRTFEIRYFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYA7</accession>
    <name>A0A0D1YYA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240487.1">
        <property type="nucleotide sequence ID" value="XM_016375211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYA7"/>
    <dbReference type="GeneID" id="27327929"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00846"/>
    <dbReference type="HOGENOM" id="CLU_1475182_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW20271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="183" mass="20546" checksum="1C4F29A098E3E078" modified="2015-04-29" version="1">MPVPPHSTAVNTFTVYGSICDYWTTPDQEWILYYRLHVYCDYVGQGTKIAASVTVNNHVFSTEQIGIKDVNKIYTSPPFKSNKTADQLNFQTHKSISGGPDMGTCQCQLTKTATRSAFGTPINDWVNKMTCTKISPYLRVRSVMVREGGHPTYSGYITTPATVQTKKTLDWNDPPVAYPDWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYE9</accession>
    <name>A0A0D1YYE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00891</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016375256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYE9"/>
    <dbReference type="STRING" id="91928.A0A0D1YYE9"/>
    <dbReference type="GeneID" id="27327974"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00891"/>
    <dbReference type="HOGENOM" id="CLU_016834_2_1_1"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252268" description="Glucosidase 2 subunit beta" evidence="7">
        <location>
            <begin position="26"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="8">
        <location>
            <begin position="455"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="179"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="591" mass="65349" checksum="4D52F0408DF7E26A" modified="2015-04-29" version="1">MILRTQILLLSPLFGLSAWAAETRASESSRPRGVGPEFAKFYKKSSTDTFTCISNPSITIPFSRVNDDFCDCPDGSDEPGTAACSYLSPLSPPQYHPGPGTAAGSLNTTLALPGFYCKNKGHVPSYIRFESVNDGKCDYDLCCDGSDEWAHVGGLKCEDRCKEIGKEHKKTEEVKQKALKAALKRKSSLIAEAERLRKEVEDRIGTLETQLQAQQLRVKDAGDMLKDVERREKLRIVRGDATGKGSGKLGVLVGLSQNRINELRSQLEKTKVQRDAMLGRVAELEGLLSALKDEHNPNFNDEGVKRAVRGWEDYAARETDDGWTEAEDRDLAAVLQEDTESNGINWAEFENEPSEPESDVAALYKFSSYLPDGIRIWLDDTLTSLRKILVENGVLPDNSDPASQAAESKAVQDAKKALSDAERDVRNTENDVKRHREDLEKDYGPDNGIFRALKDTCISRDSGEYEYELCFLGQTKQKSRKGGSQTGMGNFVGFDWDYVDESVGADGKGLGTGERLVMKYENGQHCWNGPSRSTRVILACAEKDEIWKVSESEKCVYRMEVGTAAVCEPPSSGNKSKPSTSEEAEGKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZB3</accession>
    <name>A0A0D1YZB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240852.1">
        <property type="nucleotide sequence ID" value="XM_016375576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZB3"/>
    <dbReference type="STRING" id="91928.A0A0D1YZB3"/>
    <dbReference type="GeneID" id="27328295"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01212"/>
    <dbReference type="HOGENOM" id="CLU_032862_1_0_1"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="97"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="294"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="459" mass="50743" checksum="DA1E38D1E5364071" modified="2015-04-29" version="1">MASPRVLHLPRAQSLARACARTALAPPGSASLRPFHSTTPLGTDGVFKALTEMRVRKPWIEALRERREAKKNPVSTPEETVKPDLTPKRMSDSYVSVVLPLSKDPWMLDTYANYTGQIRTGTLLMDLDALAGVVAYKHTGEGVTTVTAAVDRITIKNPIREICDLQLSGQVSFATGRSSMEVTLQIAKAPEEGQKVAPEDVFMTCAFTMVALDPNTRKPLNIAPLQVTTPAEKALFAKGEENYKRKKALKSSHILAKAPDAEESSLIHKMWTDSLAYADTHNPKNQPQNVLAMSKTQIHSTQIMQPQMRNRHNFMIFGGFLLKTTFELAFTCAAAFSHTRPRFINLDPSTFEEPVPVGSVLYVAAGVSYTEADPSGGTRIQVMVRTHVRPVEHQDKERKSTGTFFYTFYTPADVSVLPQTYSEFMGWVAGRRRAQNLAATLAADPHQLLTNSQTEPLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0K7</accession>
    <name>A0A0D1Z0K7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241357.1">
        <property type="nucleotide sequence ID" value="XM_016376081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0K7"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0K7"/>
    <dbReference type="GeneID" id="27328804"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01721"/>
    <dbReference type="HOGENOM" id="CLU_035730_5_0_1"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000018">
        <property type="entry name" value="SCP-like extracellular protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237463" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="155"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="317" mass="32544" checksum="0857760CD9DD93E3" modified="2015-04-29" version="1">MKLSIAALAATCATLTAASPLDKRALTTTVVWETVTVTVTGFPPAETETSTVTPAAAAATTTDASAWSAWSSNDDWSTDSGDGWKGGWGGGWGSGWGGESTSSAASAVVTFTESEPPSSPTPPPSSAPAPTSSEAPPSSSISSSSPPISTSVSSDYQQGILDSHNIHRRNSSVPDLTWSDNMASIAAQIAASCVYAHDTSTGGGGYGQNIGAGAAPSDVPGMITNEMYNNEINWYPLPYGVEPDMTNFEKWGHYSQIVWKSTTSVGCATQYCPNGLANTGGGVSPYFTVCNYSPPGNFGGEYAANVLQPLGEPTVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZBD2</accession>
    <name>A0A0D1ZBD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_11309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230563.1">
        <property type="nucleotide sequence ID" value="XM_016385619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZBD2"/>
    <dbReference type="GeneID" id="27338392"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11309"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF252">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="56"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW10347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="447" mass="48074" checksum="769ADCDD9203DC0A" modified="2015-04-29" version="1">MAIEGVDTVRQYVGRDIADQTASPGRDKVEVEISQQPGPASSSEFTPPNGGLEAWLLVVALFLIFANTWGTTSTFGAFQAYYIRELLSTESTSTISWIGSVQAFLVVFVGVFAGPLFDMGLIRPMVFGGSFLTVFGMFMTSISRSYYQVFLAQGFCIGLGSGLTYVPTLAIVSKYFTTRRPIAIGAGAVGSSVGGVVFPIMFRKLQPQIGFGWTVRSLAFINLAFAIAACIILGRHAGQTRQARSLIDIAAFRSTVFVQWFLALFLLYLAYYVPLFFIVSYSRYGLGTGEDFAFYMLAVVNGSSILGRTVPYLLGQKVKPLYTLLFASLLGVILLFSWIAVHSRAAFVVWCVLWGFVAGVLVTAPTSTVAHPLLSPSLDVVGTRLGMTWSAASIGTVIGAPIAGVLVDVSTGNFLHGQVFGGAAMAAGAAFLIWPLISIERYDRKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZCE3</accession>
    <name>A0A0D1ZCE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gti1/Pac2 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230923.1">
        <property type="nucleotide sequence ID" value="XM_016385979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZCE3"/>
    <dbReference type="GeneID" id="27338754"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11671"/>
    <dbReference type="HOGENOM" id="CLU_1102800_0_0_1"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28782" checksum="72B80CD5B7128CCD" modified="2015-04-29" version="1">MSLECEYNVQPFYVGFVETRDDAVILIGACVRGQLRVVRRRPTLSERPVVAQSGHVFVYEEEASGIRRWTDARHWSPSRVLGEFLIYGERNQSHPVSTANQPWLGEAESDNRQQALYGPLVKSFHIALGTLVKKTIKVPDQDHSGTMWHVVSYYRPADVFRGQFQTPSTNQDFNLSPWYQPRDSVVPSGTSFGGDEMSESIVSPAMPFWEYSCATEHHHQPSWFMFKMTGDETSLMLLLHRGFPISTVEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZEM4</accession>
    <name>A0A0D1ZEM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_10717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231633.1">
        <property type="nucleotide sequence ID" value="XM_016385031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZEM4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZEM4"/>
    <dbReference type="GeneID" id="27337800"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10717"/>
    <dbReference type="HOGENOM" id="CLU_080764_1_0_1"/>
    <dbReference type="OrthoDB" id="5397701at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="221" mass="24083" checksum="76686A69CAB0EA9B" modified="2015-04-29" version="1">MNPGQTARALLRHAARPVLQLRASSTLSNNRHIYALKDPQNPSSHVLSFLSTEPPTPSLAIGSTTKLPPTPASFTENPRFLSILQAVMAEYAHADPFVQSQAAVMMSSSGASFLQASRRQQTGSFGASDQGGYGGAGRGGWVHVYDQRRVPDFGRIPDPEDIFGSIEVDGNGEFVDGHGRYEPSGTYRVVTNDGILGLSDFMRERLMQRLKLHEAAERNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZFH5</accession>
    <name>A0A0D1ZFH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231968.1">
        <property type="nucleotide sequence ID" value="XM_016383345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZFH5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZFH5"/>
    <dbReference type="GeneID" id="27336107"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09024"/>
    <dbReference type="HOGENOM" id="CLU_015590_2_1_1"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="3">
        <location>
            <begin position="316"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="574" mass="64882" checksum="8CD6410CBBF4ECFC" modified="2015-04-29" version="1">MSAEMEQNMIIERDVPIRMDDGIELRADIFKPAHSDRFPVLISLSPYGKGFEWKKGWASSWQSFWAKHPNALTGSTHSHLIWECVDPEVWTALGYAIVRIDSRGAGRSPGVLDVFGPREVEDFYHAIEWAGTQPWSNGNVGIAGISYLAMNQWLVASLQPPHLKAMIAWEGSADYYRDTARHGGILSNGFLRAWYDKQVILLQHGNPKGPEDPWLGTRSTGPLNLSEEELKKNRMDAVDVPLQMEWDGEWYRKRSPVWSKVTVPFVSAANWGGMGLHQRGNFAAFEEAASTEKWLEIHSGKHEEGFYLDYALELQKKFFDHYLKGVSNGWEKEKRVRMKIRRPFTEDFQERRADVWPLPQVKWTQLFLSAATTALLWEPASKDGQATFDALGAPLIFQSQPLAQETEITGPLAAKLFISSTTTDVDLFLTFQAFSPSGEEVEFQGSHDPHTPLAQGWLRASHRKLDPDRSKPHRPFHTHDEQWPLEPGKVTEVQIEIWQTNIVLPAGYTLALQIGGHDFERGKPVIIGERVNDGVGPFRHTHPVDRPTDKFGGKTTIHTGGEHDSHLLLPLVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHQ6</accession>
    <name>A0A0D1ZHQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232653.1">
        <property type="nucleotide sequence ID" value="XM_016384030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHQ6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZHQ6"/>
    <dbReference type="GeneID" id="27336797"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09714"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="34770" checksum="49C9B2C4CA83B42C" modified="2015-04-29" version="1">MGGFFTQLFPGKPAFTETDVPSLAGKVFIVTGGNSGVGLELVKILYSKGGMIYIAGRSPSRIATEIEAIRATPTATPGTLKSLHLDLNDLATVPSCVAAFLAQESRLDVLWNNAAISQASFVTTAQGFEAHMGTNCVAPFLLTKLLLPVMLKTAQAASKGSVRVVFASSGIIEMTGPPGGVSLDELAPGNYAKDKNHNYSASKAGNWFLASEFDKRLRKDGIVCVAQSPGTLRTKAWDNAPWVMRAMMAPFMHEPKMGAYTELWAGLSPAVKLEDGGKLALPWGRWHEGPKKHLLESLKTEKEGGTGVAGKFFDWCEEQTRSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHX0</accession>
    <name>A0A0D1ZHX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_09764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232703.1">
        <property type="nucleotide sequence ID" value="XM_016384080.1"/>
    </dbReference>
    <dbReference type="GeneID" id="27336847"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09764"/>
    <dbReference type="HOGENOM" id="CLU_257464_0_0_1"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000202">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="975"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="681"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="694"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1354" mass="152847" checksum="2187F9671E092B6C" modified="2015-04-29" version="1">MARRTFGRNDTDGMAGDRYLASEESTHQSTIHQPDWNMDTPDNSILRAGSFEPRRLEIDIDSQSWVHRGMPQHNFAPVDDFTGRCSHADARGDSSRNTLSPCVTRNDPKAVLSCSERLNANEQFPSHKGYGLTLPCGPAKPDESPPSNYSYSRSKRVASSSHAIASPIVPRSPPKVGNFSCLSYSAFLEDDATLLPEPETRPISQEQLVNEVKGIYAGLVMVEKKCVEICQQQSQTTNKLSDEQWQALIALHRTLLHEHHDFFLASQHPTASLALRRLPTKYAMPARMWRHGIHSFLELLRPRLPPSLEHMLSFVYLAYQMMGLLMESVPAFHETWIECLGDLARYRMAIEEADIRDRERWSNTARMWYNRAADHSPTTGRIQHHLAVLARPNIVRQLFYYSKALISDIPFVNARDSIMLLFSSFLDKHEKQLFYNFKTLPSTFPCVNTRDLTTLLASTSFQALSPASQSYIQKSTAAYTKFDKPLTSDSMMLLIESLVLNSDVHVIKSWKVWGPDPGLIASIPDFGSEENLRSKGSRVYSNKLQTPTSKRCEVITELNTMMENVSHPRFRKHNTINLEDFRQATLPGTAQTHHTSMSTDEVTSHILPGWSTTRSIVADKVGDRNILPYMHMLLAYLLNSYISSILSFLADPLSQSGQLLESIALIWTFGSYNQVKKNKVPFQEPDIGDDRPENLSTPLSASDAATDQVSGPPRPASHVETPISAAPLEDRTRDDLVRRLQTLENLFSTSHLEQLEAFHSTPPLQRLKDGRALLNKTRVYGRSHWTSTVCEFKWTTLRLFLTESHVEEKSDNEEVKALKSEMRAMLQKCKVLARSSKVARPSRCFSCPELTNLARLPRDTSDLMANLYLSKFETSFRILHVPSFLAEYDQYWTNPSAAPADLKLKVQLVIAIGSSISHKRSASAEIRSMASHWIYAAQNWLAGPLEKDRFSISGLQVHCLLILARQILCVAGDLIWVSMGTLLRTAMQMGLHRDPDNFPKMCILQAEIRRRLWATILEYIVQSSLDSGMPPLITFEDFDTTAPANIDDEEINEHTKVLPQHPRSQVTATSAQLVLLDSCRSRMKAVRCMNGLGSKLLYDEVLALSADISNACQVSLAYTSKLKSAPFSQNMNDLLLRRFLLPLHRLFANKANTNPLFYFSKKTCLDCVMAFLSSDLDEDFSQILRSGGGFLKGGILYMFFALGIEVVQEFQEEGIKNAQPHRQWLINALDKAIELAVDRLRLGETNVKMHLMLNMIQAQIQPSDNPTELSLRLGRKGLEALQTSYNILQANAAPSHECSVNETDMTFFDTGQDTSMSLDYRFDDLLMNTDMMDGMFENCAAQLWPQDQGYCPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIG6</accession>
    <name>A0A0D1ZIG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232873.1">
        <property type="nucleotide sequence ID" value="XM_016384250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIG6"/>
    <dbReference type="GeneID" id="27337018"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09935"/>
    <dbReference type="HOGENOM" id="CLU_071883_2_0_1"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="256" mass="28200" checksum="AF009EC1EDD1EC23" modified="2015-04-29" version="1">MLVAPGSRSVMDKGSSNSEGFRPWLYKAMRLRADNDLRSQTYLQQMPKSFADIGPAKGYIEALETRLKETERLLWRMLSAASANVEILAESFNAELDHRIPASLCVSTLSTTDEKKSAIAYWEQYPLQTPEDVILWKQDLDSQSGMAALGSRNVVDNSLFERLEVASPSDPSPFEGSFPSADPSPVQDIAHEAGEDVASQGGVPFTPEPRSFHPSAPSQTSQNVGDALRQPSTRSHRSSTAAKFGLSQEFEDTFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZLK5</accession>
    <name>A0A0D1ZLK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233933.1">
        <property type="nucleotide sequence ID" value="XM_016383230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZLK5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZLK5"/>
    <dbReference type="GeneID" id="27335991"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08908"/>
    <dbReference type="HOGENOM" id="CLU_539675_0_0_1"/>
    <dbReference type="OrthoDB" id="5419235at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="538" mass="59015" checksum="B69E47BC75B55BBC" modified="2015-04-29" version="1">MTGNNGLAGGLWVARATKPELLSRRSPVWRKTVLRITQWSRDSLRQSSAPNAYSGNGDLLIFRRSPLLSSLGKIESVTHPRLLNSQLSPHPPQSTRPPGPVNKRDFVVASRAPDSSPTATINALDFTSFTTANQQPWRLSTQAPSTASSQNSIQHSFNQDFQLFDVPETSQVLPIASRAQATLSIVPNNSRPLQTRHLSIGNRVSPIQSSQSQFSGNTNHRSFSSPSLHKRLSAQHLRQLAHSQSLSHSRPPVPLFNAPAPNSHRQSRPTVTIPQGTKHPDPLWRAAQRLTSPGFMSSAFDQMYLPGGDLLASQDDFFNIGANYSAQTEFNATSGTVSPSELFRDDYTMSAPPSTAFPNFSTPESGYLESPAMPSSGLNTSPLEDGLLDGQLNYSELEAMAPLFPKDEFDQFAQQSVPTAEQLKASFESVKAKPAKRSEPVAPMVRQKSSPGRPPSQPLIHGRKLSDTVGINKSKSRKILPEITIDSEDDKETAKRKKNTAAARKSRQRKQEHTELLTTEIQRLRAMVLRLGGDPDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZLT2</accession>
    <name>A0A0D1ZLT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234018.1">
        <property type="nucleotide sequence ID" value="XM_016383315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZLT2"/>
    <dbReference type="GeneID" id="27336077"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08994"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF156">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="57620" checksum="7F14C5113E042993" modified="2015-04-29" version="1">MAPSNSIGLRQQRSSTGLETAARRDGDDEVVAIEGLDISTLPPSRRLSNRGKARVIAGNALLQLPIWGFPMTYGLFQDFYTSSWPLSGSPSGTGVIGTTSNGIIYLSMPFLFAALSQRWAHLRRRVSYLGIALAALSFVLSSLSTRSWHLVATQGVLAALGSALLYSPTTLSLGESFTIDSRALAYGVIYSSKSIVGSTCPFLLRGLLDAYGFRNTMRIWMAIITCTSMVAMFLLPRDPLIQQSHHCHRHTRTRTFSRHRAEQQGQQQEEAEEEEEDRSRASPAHHQPRRTAWHFLSYRTFYIYIVATMLQSSGYGIPQTYVNSYAHSQARLSATSSTLLLTLFNVPGILSSSFFGYLSDNRFYPLSATTTTALSSVTSALSVWLLWGLAPARGGSMTILSLFSVMFGFFANGYSATFGGVCKQLECEAIERNQALDAGVVFGMLNGARGLGYVIGGVAGVSLLKVGGKKLGGDDGHGHGSGLGRAAYGTEYGPLIIFTGLTIIFGGWSVAWKLFNKRVFKLLFRCFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZS57</accession>
    <name>A0A0D1ZS57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235848.1">
        <property type="nucleotide sequence ID" value="XM_016380021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZS57"/>
    <dbReference type="STRING" id="91928.A0A0D1ZS57"/>
    <dbReference type="GeneID" id="27332763"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05680"/>
    <dbReference type="HOGENOM" id="CLU_028123_2_1_1"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3110.10">
        <property type="entry name" value="protoporphyrinogen ix oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.20">
        <property type="entry name" value="Protoporphyrinogen oxidase, mitochondrial, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="511" mass="56992" checksum="535E749A8198B805" modified="2015-04-29" version="1">MGKKVAIVGSGCSGIAALWALNTSTDHEVHLFEAESRLGGHTNTVTFEAPNGATVDVDTGFIVMNSATYPNFIRFLNEVGVSTKKTEMTFGVSRDQGSFEWAGTSIGSIFAQSKNLFSPGMWRMIFDIIRFNEFAIDLLHAESESENDIADKMEAGSKNKPVAEETIGDYLDRENYSQEFRDDYLIPMTAAVWSTSPDKCSLEFPAVTLVRFMYNHHLLSTVARRPDWMTIPGGSKQYLDAVLQGFDKTRINVECKVTALETVDDKVVLTANGRDQEFDHVILATHGDQALEIVKSGATQEEVGILSGFQTSRNVAVLHSDLALMPKRRVAWSAWNYITESPFPPTNSQNISKVCLTYWMNLLQHIPDDKYGPVLVTLNPLNMPDPRLAQGIWEYSHPLYNATAIKSQKLLPRIQNIRNISYCGAWTKYGFHEDGFSSGLSVAVNHLGARLPFQFVDSTFSRGARPIMTWKNHIARSLILSVQIVMLLFGKAYTTLAAILDRRIASRRKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWS7</accession>
    <name>A0A0D1ZWS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237353.1">
        <property type="nucleotide sequence ID" value="XM_016378676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWS7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZWS7"/>
    <dbReference type="GeneID" id="27331411"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04328"/>
    <dbReference type="HOGENOM" id="CLU_029940_1_0_1"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="31"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="304" mass="34667" checksum="57E8FBA7DF66E7B6" modified="2015-04-29" version="1">MGKKRVLVGYGIDVDAVSGWINTRDGSPANPTDVSRGVFGATVGIDRLLNLWDKYGIKTTWFVPAHSIESFPEQLSKVKDAGHEIGLHGYTHEFVSTLSEQQQKDVLTKSVQVLTDFTGKKPRGWTAPAWSTSRQTIKLLEEFGIEYDHSFMHHDSQLYYCPDGSEEWTETDVAKSATEWMKPMSAIKPSAVVEVPANWHLDDWPPFQLNLKQPSTHGYVDTYVIERLWKDQFSFLYREYDTFVFPMSIHPQVSGKPQVVLMHERIIEWINQHEGVEWMTMEDMVKEFKEGRLGGAEVKGGKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3K4</accession>
    <name>A0A0D2A3K4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239678.1">
        <property type="nucleotide sequence ID" value="XM_016374402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3K4"/>
    <dbReference type="STRING" id="91928.A0A0D2A3K4"/>
    <dbReference type="GeneID" id="27327117"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00034"/>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000048">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="169" mass="19206" checksum="98E9B858D98290F8" modified="2015-04-29" version="1">MSPSSAAATLLQRQLKQMKSDKDIPGISCGLADDNIFEWEVMLMINDDCKYYGGGFFRARMSFPQEYPLMPPKLKFETPIFHPNVYPSGEVCISILHPPEEDKYGYESVAERWSPVQSPETILISVISMLSSPNDESPANVDAAKLWREDPKAFRRKCQRIVRESLGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4I6</accession>
    <name>A0A0D2A4I6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239968.1">
        <property type="nucleotide sequence ID" value="XM_016374692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4I6"/>
    <dbReference type="STRING" id="91928.A0A0D2A4I6"/>
    <dbReference type="GeneID" id="27327409"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00326"/>
    <dbReference type="HOGENOM" id="CLU_125087_0_0_1"/>
    <dbReference type="OrthoDB" id="5418922at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="208" mass="22698" checksum="FC01BC0BF7A7CA63" modified="2015-04-29" version="1">MPKSNSTIAAPLREALFECFRSITRLVRPSLRRQLVLVGGAASIAHSSVLVTEDVDVVGPPSALIEIWEGVSTGARNFQFESDGKIVFDAPLQDIRIRVNLIEIGKGCVERIIVAEPFFEGSVASMSDLLRLRAVTVVDRGSDGEVEDFRWLLSRVASRGQILPELDKEELECIRGAAESCLGRLDRLVLGAVLGVNNFPLAYHLIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT82</accession>
    <name>A0A0D2AT82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_12019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847503">
        <property type="protein sequence ID" value="KIW09735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229951.1">
        <property type="nucleotide sequence ID" value="XM_016386326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT82"/>
    <dbReference type="GeneID" id="27339102"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12019"/>
    <dbReference type="HOGENOM" id="CLU_2096897_0_0_1"/>
    <dbReference type="OrthoDB" id="4122726at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="126" mass="15141" checksum="34CADA1B603FAEA6" modified="2015-04-29" version="1">MKIHLEWHDVVKGNRVPGRRFNGDNRQEIAEIRRKTQEYESRRRERADNRLKGHMDEHQRQLYEAETLFDLQTKQLSKMAVVQNKEIDLDPEEKAAQRKEWDELIQPSEAILEEIRQEIFSNTGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATZ7</accession>
    <name>A0A0D2ATZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230434.1">
        <property type="nucleotide sequence ID" value="XM_016385490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATZ7"/>
    <dbReference type="GeneID" id="27338262"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11179"/>
    <dbReference type="HOGENOM" id="CLU_126094_0_0_1"/>
    <dbReference type="OrthoDB" id="59229at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="141" mass="15283" checksum="BCF48BB68CD2350C" modified="2015-04-29" version="1">MFRMSKTLDVITLFHKPSISASVRVQNLLKQASAQASQTATEDQATDHTAQNETVTRDPFEIEVTEAPPTPDQLKSIFEYLGGGVAGELVKGAASQSDALRKVKEDGNAFTRPVVVDWTRGKAVIGDKQSEILKLLKADGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVA4</accession>
    <name>A0A0D2AVA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230869.1">
        <property type="nucleotide sequence ID" value="XM_016385925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVA4"/>
    <dbReference type="STRING" id="91928.A0A0D2AVA4"/>
    <dbReference type="GeneID" id="27338700"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11617"/>
    <dbReference type="HOGENOM" id="CLU_037990_3_2_1"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="105"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="382" mass="43292" checksum="AA3BF7C029102C74" modified="2015-04-29" version="1">MPPPPPPSPRTSLASRRTGRSFNLYFYSVCGVGFILSTYLMYMYTSYRRAVAESQMLDLPQNADVSSRWMDLSRNFDDEVDFSEHFMLLGKRRRNLCRQAVGNVLEVSAGTGRNLQYYNLDPLRTPRDRRIKSLVLNDLSEIMVYQAQKKFEHMQDHTENIAKFRGDVRFVVGDASDRRLIARPDGGFDTIVQTMGVCSMANPVAFLRRLGELVRQPGERSTGVSLGAKALKEEEPQQRKIDYGAEEEAQESEKNTAEREPQSTVSDKGGKILLLEHGRSYYGFVNRFLDNNAKLHAHRYGCWNNKDIDQIIQDSGLVVESKRRYHLGTTYEYVLRPNPRQRAAEKEVTTANATSSSDAVAVTAAAAAPGSEQSKSAWWKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVL6</accession>
    <name>A0A0D2AVL6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230994.1">
        <property type="nucleotide sequence ID" value="XM_016384392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVL6"/>
    <dbReference type="STRING" id="91928.A0A0D2AVL6"/>
    <dbReference type="GeneID" id="27337160"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10077"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_7_1"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW10778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="316" mass="35043" checksum="B1B03C7ACA3E99FF" modified="2015-04-29" version="1">MAEQLIQRGTLEGHSGWVTSLATSLENPNMLLSASRDKSLIIWNLTRDESAYGYPKRSLHGHSHIVSDCVISSDGAYALSSSWDKTLRLWELSTGNTTRTFVGHTNDVLSVSFSADNRQIVSGSRDRTIKLWNTLGDCKFTITDKGHTDWVSCVRFSPNPQNPVIVSAGWDKLVKVWELASCRIQTDHIGHTGYINTVTISPDGSLCASGGKDGTTMLWDLNESKHLYSLQAGDEIHALVFSPNRYWLCAATTSSITIFDLEKKNKVDELKPDFVEKGKKSQEPYCVSLAWSADGQTLFSGYTDNKIRAWGVMSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVP1</accession>
    <name>A0A0D2AVP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_11449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230701.1">
        <property type="nucleotide sequence ID" value="XM_016385757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVP1"/>
    <dbReference type="STRING" id="91928.A0A0D2AVP1"/>
    <dbReference type="GeneID" id="27338532"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11449"/>
    <dbReference type="HOGENOM" id="CLU_009665_14_3_1"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF6">
        <property type="entry name" value="FAD_NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="34"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW10485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="575" mass="64256" checksum="1C811F76D01D8E7A" modified="2015-04-29" version="1">MLESVDTTNPGQRPNSFAGHEHDPYSLDISVLIVGVKSLVVERYPERLGAPKAHALSPRSLEICRQSRLDGAKIRQLGTQRRDAYWVNFVTNLSGQPIGALPYERMDAEVFQHTPEMIHNIPQPAFEQYMTDVLAKDSNVEIRRGISFVSLRQDSHAVSTTVEDRTTGHQFQIRSKYVIACDGARSKVRACLKIESDGEDSYETMMTIHFNANLRPIVGDRVGMLHWIFDPVASGFIIAYDLSGNLVLISNFDATKQPVESWNEDVCRQTVTSAIGKDISFDILSYRPWVLSRKVARSYRQGNVFLAGDAAHSFPPTGGLGLNSGLGDVHNLAYKIALVLNGEASERLLDSYEGERRHVAVVNSMQSVKNGRKIFGLLKTLGIGQDTAQARRNLYASLSDPDKKREIDEGIEEQREHFDNLELHIGYVYGDRSIPPHASKYVPKFTVGARLPHAWIRLLPQSQRTTPTLAPVDVSYIDEFSEEDIRLRQYSTLDLCDMDKFTLLGNLDVPGVKTFRPGRDFEVVGPGAGEWLDSSRLPEGGGLLVRPDQHILMVLDADTTAHDVQLVLKKYLCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVT1</accession>
    <name>A0A0D2AVT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016385782.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27338557"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11474"/>
    <dbReference type="HOGENOM" id="CLU_891463_0_0_1"/>
    <dbReference type="OrthoDB" id="4157279at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="359" mass="39594" checksum="F831809CDEBAB542" modified="2015-04-29" version="1">MEAVTEAHPDRKVKDAAVPSRATASLKVKRMASIPEEPNEMPKFRVEVKAKARQSESDSEPEDDPPCLGNCDLEAQGQSEQVLEYVAKIREAIVLQGLRVQCEEETLDEAESEVTKTELHEEKFRSGTTENKKRESGLFTMSAKTKDALNGLKAKRQSVFGDVEAMTRHAVSAFKVGSKESTPFETPNSDIARSKVRSAGTRISRALSARQGVTSMQDTTPLKPQTTRTAVVTAAPPSPDSRCEKDDDKETHLIQFDINSLSETDTDDGEDTALLSSQNLSSKPGIARSRSRSRSNAQSGKRYRLPTPYRYRSRESRHVEMSRRVRKGLGAARGVVADVKVAAKNVLSVYRKVGGWSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AW80</accession>
    <name>A0A0D2AW80_9EURO</name>
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        </submittedName>
    </protein>
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    <organism evidence="2 3">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="91928.A0A0D2AW80"/>
    <dbReference type="GeneID" id="27337137"/>
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    <dbReference type="HOGENOM" id="CLU_2606046_0_0_1"/>
    <dbReference type="OrthoDB" id="2137750at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019626">
        <property type="entry name" value="Stress-induced_KGG_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="79" mass="8885" checksum="85BE4E4F89E80D83" modified="2015-04-29" version="1">MSSKENNPGNFANRPKEEVKEIASKGGHSSAGGFASMDPDKQASSTVVTQSLQIQYANRDKARNRFRRWSGLEWEVRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWU9</accession>
    <name>A0A0D2AWU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
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    <dbReference type="STRING" id="91928.A0A0D2AWU9"/>
    <dbReference type="GeneID" id="27337561"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10478"/>
    <dbReference type="HOGENOM" id="CLU_048020_0_0_1"/>
    <dbReference type="OrthoDB" id="3533623at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="523" mass="58662" checksum="8DB8707AD6F8DA0D" modified="2015-04-29" version="1">MASPDMEKHSQGAAYPWVLEHLLAYPGTYEIPLRTMYTLNATTQNQPQSPPLPSKAVPGNAFPRKVSDAAEEQQNMTTMTAAAQLRANLMAHISQQPSQPTSLPPSFITSFVRRCFPPELDQVDFPQALTAMDYLKDLEVRRRREVVAAFDKLGIDQEDISHRDKLARKYPGVLRWVMDIEEKERKVEALYTQVYIGLRRWTLINELSLTPFNKANCIAMLNTLYPPVGLQNKHFVQPTAQLTSQVLASQSAMFFKYITAVEQKGTAVLGTLMDQNKQPGDATGWTHLRTTVDNYLRMANSVIDECYDITGRGCQSPTAASFSSIDLEDEGRRKVDSGISFTSTSSSNRNSGQSHVTRPSTSSSFSTGSRNHSRQVSKDKELPEKPLPPPKDDDPTVTQKPGGSTMERIARELRKIKSRKDIKDDARPRTAAVQPVGATSPTTEQYPAAPSRDRGLSFKRSLRRMRSNSGFTENTTIRPLSRNNEPTIQEVPAFDADEMKRRRQDWESQQTVRNQASHANMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AX46</accession>
    <name>A0A0D2AX46_9EURO</name>
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        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10284</name>
    </gene>
    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016384599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AX46"/>
    <dbReference type="STRING" id="91928.A0A0D2AX46"/>
    <dbReference type="GeneID" id="27337367"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10284"/>
    <dbReference type="HOGENOM" id="CLU_020336_4_0_1"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="40"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="287" mass="31465" checksum="EBF68F6EDB066E74" modified="2015-04-29" version="1">MSTYETAQTQYVSVKGVKHAYRLFGQSSGTPLFLHVHFRGNMDWWDPAFINPLAAARPILLVDNTGVGLSEGEVPTRFVDWATGILDVVNALGITKLDVLGFSMGGFVAQLMALQAPDLVRRLIVGGAGPSAGEGVVASDPKHFVEVASASTFDESHAGLKHTFFTQSEKKQALAEEWIQRMANARTNRAPLLGGQGLQNQIATVQRFFSGEHPEEGTYDRLDQIKIPVLVANGSNDLLVATENSIVLWKRLVNSDAQLHLYGDSGHGFLNEYHDQFSRLVNEFLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXA9</accession>
    <name>A0A0D2AXA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231241.1">
        <property type="nucleotide sequence ID" value="XM_016384639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXA9"/>
    <dbReference type="STRING" id="91928.A0A0D2AXA9"/>
    <dbReference type="GeneID" id="27337407"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10324"/>
    <dbReference type="HOGENOM" id="CLU_004471_6_3_1"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="475"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="707" mass="80203" checksum="BFB0B132FBC863C3" modified="2015-04-29" version="1">MSVNDYKKARGALSGDADEEADIKKIEMVDIIETEGRWGSRSTITLTADIHKARQDKDRFQEYALILRRLRDEDGKPLATRLEIQSPIIRAAIQEVLGEYPTINMESNPIIIERPYAPLYHYRKELREYAVHADRTKEEKDHMSTLIHFMDLYLRKAEKTNEKLLPSELTSHALLWTLYRPDDVVIARRDYFTEAYVIESCSVVEFPQDNEIKMRITLVCRSWDYNGARFGPVTKTINLRSFIGNKKIYDLDVYPIQYHREPDGQDIRRKLINRGLKWRNIVEVAHREYSAICWTDPLTQAEEVRQIEDLVPVHTSGRIILDYATHQQARPQLATLLARGSATKAVTKDAKDAIPANQGDDFLLKADDSSKPNKRERSEYDDRYLSHPNDATYKMTHSQALICPARIRGFSLTDKIWAFFLVDEVKDITWAEDSFKTLELEPSVKKTISALVHSHGKSNKAQDQTADDVISGKGKGLVFLLTGPPGLGKTLTAESIAENTHRPLYALTCGELGTDPVETDQILRRIFIRAKSWNAILLLDEADVFLAKRERNDLQRNAFVSIFLRLIEYYAGILFLTTNRLTEFDEAFQSRIHLTVHFKLLDDTMRAAIWKNLLSRFDPGPQWRTDALAKLGREYRINGREIKNLIRTAAALAEFEGVALDESHFRTVYKLNTTQYCDGLDVPVATGGGGGGGGGGGGGLVPGTGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXJ7</accession>
    <name>A0A0D2AXJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="13">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_10733</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="13"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231649.1">
        <property type="nucleotide sequence ID" value="XM_016385047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXJ7"/>
    <dbReference type="STRING" id="91928.A0A0D2AXJ7"/>
    <dbReference type="GeneID" id="27337816"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10733"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000157">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="359"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW11433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="416" mass="47423" checksum="AEDBDFD4B62EED17" modified="2015-04-29" version="1">MGDLSGRKVFKVFNQDFVVDERYTVTKELGQGAYGIVCAATNSQTGEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNITCLFDMDIPRPDNFNETYIYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSQDPEENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHYLGTPSEETLSRIGSPRAQEYVRNLPFMPKIPFQRLFPQANPDALDLLDRMLAFDPSSRISVEEALEHKYLHIWHDASDEPACPKTFDFSFEVVEDVQEMRKMILDEVMRFRHHVRHQPTQTPTGANINVPIPENPGQWAKGAEDPRPQEAGSFVGNDLEHELQAGSDSVMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYU3</accession>
    <name>A0A0D2AYU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MT-A70-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232099.1">
        <property type="nucleotide sequence ID" value="XM_016383476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYU3"/>
    <dbReference type="STRING" id="91928.A0A0D2AYU3"/>
    <dbReference type="GeneID" id="27336239"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09156"/>
    <dbReference type="HOGENOM" id="CLU_027091_4_0_1"/>
    <dbReference type="OrthoDB" id="61116at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32093" checksum="3A12D8B70869FDD4" modified="2015-04-29" version="1">MLPADREYPTQASLSFPAHSRTFVAGAGTDHMVPLLLSSTERRNGFPSLDMLHGVLVHNPSHGSAVLETIDNGHYFIPPRSTFICSTLQSGQSALSAWQHLASSNGFDLILMDPPWANRSVRHSGHYRSAEDQNCDPFGQAAQIVETSLSSQGLVAIWITNKASLRANVVQTLGAMGFCVDEEWIWIKVTAHGQPVTPLDGLWRRPYEVLLLFRKRHSDVNPRRRIIAAVPDLHSRKPCMKALLQDLLPPQPQVLELFARNLTAGWCSWGDEVLKFQHESHWVGPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZ46</accession>
    <name>A0A0D2AZ46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231961.1">
        <property type="nucleotide sequence ID" value="XM_016383338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZ46"/>
    <dbReference type="STRING" id="91928.A0A0D2AZ46"/>
    <dbReference type="GeneID" id="27336100"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09017"/>
    <dbReference type="HOGENOM" id="CLU_000680_30_3_1"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21167" checksum="5E959F107EBFA8BA" modified="2015-04-29" version="1">MGTLPTRRPRQNRGQQQVAPQTTMLLTKAKHTINQALQKDWEVLWTHGRHGRTLHRLGTKPDKKTLQLHQNLPRPISSVITQMRTDKIGLAAYLHSINKAETSRCSCNHGEQTVEHVLLKCRQWVTEREEMWAGGRRVLSLKGVLNDPKMVVRAAKMMLKTGLLGQFQHINAESLEASSQRQAKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZI7</accession>
    <name>A0A0D2AZI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_09397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232339.1">
        <property type="nucleotide sequence ID" value="XM_016383716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZI7"/>
    <dbReference type="STRING" id="91928.A0A0D2AZI7"/>
    <dbReference type="GeneID" id="27336480"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09397"/>
    <dbReference type="HOGENOM" id="CLU_016972_4_3_1"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254065" description="endo-1,3(4)-beta-glucanase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="8">
        <location>
            <begin position="28"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="460" mass="47705" checksum="26B2B16B3E45B91C" modified="2015-04-29" version="1">MHISLTTFTLFVSAATASYVIEDDYNSDSFAGMFDFFTDDDPTHGYVNYVDYNTASSSGLYKVQNGQVYMGVDSTNTASGRGRNSVRIASKNTYQHGLVILDLAHMPAGACGTWPAFWMLGADWPNNGEIDIIEGVSAQTANNMAVHTSDGCTISNTGGFSGTLETDNCYVGAADQATNAGCSIRSNDDQSFGAGFNSVGGGVFATEWTSEAISIWFFPRGAIPSDISSGSPDPSGWGLPQGQFQGACDIDEKVQNQQIVFDVTFCGDWAGSVWSTDATCSSQASTCQAFVQNNPSAFQDTYWLINSLKVYSDNGASPSQPPASSSLSVSTQQPTGTSSPSYTFPATTTFVTVTSGGVTTYTLPPTTYTLTSAPVETTQQQPTSVPTTAVPPPSGATTVYTTEIVTTAAPTPAPSSDNNNNGGGWSWGGNSGGGNRGGSGGGRWGGSGGGGGDWSGGWGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B132</accession>
    <name>A0A0D2B132_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232829.1">
        <property type="nucleotide sequence ID" value="XM_016384206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B132"/>
    <dbReference type="GeneID" id="27336974"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09891"/>
    <dbReference type="HOGENOM" id="CLU_052827_4_0_1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="120"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="215" mass="24300" checksum="D1913C96AA493D86" modified="2015-04-29" version="1">MDRSYLTMLRHIPVPQEDVDFFSSFPFVSPYLSKKSRYQPVPFLTRHKITPNDTSDLFFSKTINSHDTIPRMLALMRKEDLQHPTPQTTTSVDTPAQGPQDPYFVVFAQLESGVNGYRDTLHGGVLASLFDEALGLCVEGCRETGSPGKSWLLTASLEVNYRSAVTTPCIVLIKTWLERTEGRKWFLKAQLLDQDNSVKAEARTLYISSRNHASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1X4</accession>
    <name>A0A0D2B1X4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233124.1">
        <property type="nucleotide sequence ID" value="XM_016382421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1X4"/>
    <dbReference type="STRING" id="91928.A0A0D2B1X4"/>
    <dbReference type="GeneID" id="27335178"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08095"/>
    <dbReference type="HOGENOM" id="CLU_044876_3_2_1"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="306" mass="32653" checksum="DE83F10CFCD70F69" modified="2015-04-29" version="1">MSSTSSSKRIAVAGVGSLGLPVVLALLEAGHAVTILTRSASTKKEGIPAGANVEYAAVDYTSVESLKKALEGHYGVVSTLTTTSVGAQAPLIEASVQAGVSRFIPSEFGSDTTNPKAKALPVYGAKIATQEKIEEVAAKNPGWSYTAVINGAFFDWGVKFGFLGVDLKKHTATLYNGGDRRFSTTTLAGVAKAVVGIFSHPEETKNREIRVHETVITQKKIIDIAKRLDPAEWTYKAADTEELKNQSFEVLKSGKVEEIPGAMINFLASAIWGEGYGSEFVETENDLLGVPLLDEAEVEKVIAQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2G7</accession>
    <name>A0A0D2B2G7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07992</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233021.1">
        <property type="nucleotide sequence ID" value="XM_016382318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2G7"/>
    <dbReference type="STRING" id="91928.A0A0D2B2G7"/>
    <dbReference type="GeneID" id="27335075"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07992"/>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="440" mass="48840" checksum="A198D2DD4D7224BA" modified="2015-04-29" version="1">MAGDKSYLIVGAGVFGVSTAYHLIKKYPDASVTIIDRDAYDASSRVAASWDWNKVVRADYDDIVYCRLALEAQDVFQTEALWKPYFHQTGIYWMCRDDYARDVVDNYKKLGRRADLAAVPVDEARKLYGGLFEDADYTGVKEVLVNKTSGWAAAGDCLIAVTKEALKLGVKYVTGEVQTVLLGTDGQGQRRCTGVRTTQGDVLTASHVLLCTGAYTPKLLELSAASSGHEDLSAGKRIVAGGITTGMTTLADDETYARFASMPVGVQGYTAEQGPFIGSLPPTKDRELKWWGQTIFRNNREVLPGRVLSAPPPEPDYAQWKVSGRLKEDINHANHVFYGKNGAKWKMEKHRICWDAFTTSSDFIISPHAAAKGLYVATCGNFHGWKFFPVLGKYIVQMLEGTLSPELTEKWAWDRERPDPSGFADYPRWEMKELIGASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2H8</accession>
    <name>A0A0D2B2H8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">37S ribosomal protein S22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233329.1">
        <property type="nucleotide sequence ID" value="XM_016382626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2H8"/>
    <dbReference type="STRING" id="91928.A0A0D2B2H8"/>
    <dbReference type="GeneID" id="27335383"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08300"/>
    <dbReference type="HOGENOM" id="CLU_007075_1_1_1"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="862"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="959"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="983" mass="110415" checksum="CD795119970F32A4" modified="2015-04-29" version="1">MLSRSRPTGLCHPCRQDLQLLLERGFCGPPVALGNRHVPLSWRQIPKPRLQLRYFSEASKILHRSMAGSHETLRNVGDRFVDDDLSRAPTDTLNRLGNPVDQSIGDEDALAQDYRDLSLLTSPIGENASERVVLGTRDVLAELRNDGATLEEVVREARKKYGDTLPETALNGGELKIYKRLYGDPVSMSHEELLNEDDAVEVDGGPETWLYDQEGEVIEYQTSTNDPMTSEAMHGIRSSRPPRPAQEDLAFDDEGAMTSSLLTSPAERAMEVARSLNANVVDEIVEEEFFDDDSARMHPFTRLGKFSTSNGNVQLPQGEFVRPVNRLMSNFSNKHLKEICEKTFGGPGLPDSPLTPRSGRARAQISIPIDASQQSMGEMEANAFVTTVMPPTYAAVMSVLVETRKRLGSTWLNNLLAKEGGPRILDAGAGGAGIIAWRELVQAHWDAMHDSDRNPPPPPASKSVVLTGSDSLRHRAAALLENTTFVPRLPNYVHTRDIPTLEDDRPAQQRKQFDVVIATHSLFGLQEDYMKKQHVENLWSMTNREGGVLILIEKGVPRGFEAIAGARELLLERHIAVPEGKKTAYSDEHGSDETHIREPGMIVAPCTNHEKCPMYRVPGISQGRKDFCSFQQRYIRPNYLQRVLGARDRNHDDVDFSYISVMRGDDLRRRQIESWLGIEDGLSAPRHPDPKTMGEDYQTWMQLCQSGFEDINPNTALTHSNPFPDGKERSSLPATWNLPRLVFPPMKRRGHIIMDVCTPAGQIERWTVPRSFGKQAYRDARKSRWGDLWALGAKTRISRSLRLGGPDTKEAKRARNRNQRLKDQAEELMEKMEQEKMTEREEEEEFASVFEDDLIEDVEMPIARTTKSRKSKPSSSGSVETFSFDDINDGGMNHVRPPQSRVPSKVLSSESSEDRPKAIEDDDLSDDEWETLEQWEKELSAVQFQGGKSKRLRTYSKFAAPGHKTRATKDGKIRRAGGVALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2K6</accession>
    <name>A0A0D2B2K6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233061.1">
        <property type="nucleotide sequence ID" value="XM_016382358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2K6"/>
    <dbReference type="STRING" id="91928.A0A0D2B2K6"/>
    <dbReference type="GeneID" id="27335115"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08032"/>
    <dbReference type="HOGENOM" id="CLU_356021_0_0_1"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="244"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="788" mass="89627" checksum="B015F6570BE0229E" modified="2015-04-29" version="1">MQTDAGAATLSKPRGAMPLCPNCTKLPLDALRPRQLTPHGRPYASLENAFKEAEDACFRIGTLKEIEARSDRCSLCGLLWKAVVSWHPADPAHTHCKVYVSAVGTAYGYERYNGVGGTNTIRRAVQISRMRVTFQGSAKTRRSESSEAAQDFDFELHAGAEVVSPKRDSSILARYRPQSCDMALIRSWLTQCCQEHQSICDKPRLLSSVTISMKQGEPYQIRFIDVQRRCLVSAPSSELYCYRYVALSYVWGTNKQPLGLHRENSKALHQDGGIRNASRTVEDAMKVTRELGYRFLWCDVLCVTQDDASQKAADISHMYQIYTRADLTIIAAGEGTADQGLPGISYERTIQRSAQIQPDLWLYTATRQPLVTRSGIALSCPWSTRGWTLQEQVLSLRCLFFLEDQVIWRCQSCDRFEDLALERTSEEPLHLRLEWARTQPEGQTRKAHHSKPQHAANIFHIENPFMFEQNFAALAKAYATRTLSFNSDIENAFQGIMTGLAKDFHKGIPVKRFEEYLCWSRHDPRKQLLCRRNDCPVPSWSWMAWKGPISFTEVASTTFPAIVCYRRVAQQTDDPAHLITVQLHTVTQKRFSDLSGSGCHEDSDVRSYLTNGADREWRKLRDDPRLTLSISDIKDVEINLNHLLFYADVADRVEVRLVSSRQAGRHTWMESYEILDADNPRHPLLKFKELAGENSTFGTAESSGAADLATIQKPENERKDHSLFAVANLFRTTYNYSGGSESREYARDRVCVMRVSWHGRVARREGVHMINSKQWDPLPKRRELIILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2K7</accession>
    <name>A0A0D2B2K7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="6" type="ORF">PV08_08340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233369.1">
        <property type="nucleotide sequence ID" value="XM_016382666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2K7"/>
    <dbReference type="STRING" id="91928.A0A0D2B2K7"/>
    <dbReference type="GeneID" id="27335423"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08340"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_8_1"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW13153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="558" mass="61678" checksum="8B36426FE8E20222" modified="2015-04-29" version="1">MTESSPPELSLLKTLKHPSTGPSRSWQSLAHPDPSTPLLATASADKTVNIWNLRDYSLISTISGGHKRSVRAVSWKDYGSHAGKNKKPVVLGTGSFDANVGIWIWNDDRRWSRFRDNNGDSNNNTNNHEPSSRGGGQEAAMTEESGNEMDLTRDDGDDEEDEEWHFSTLLTGPDSEIKSIEFSPPHYAANLLATCSRDKSVWIWEEVEPEEWETIAVLSEHTGDVKCVSWCAGASRGNGRKTKRRKLENPSDGDVEMGNGSGHVNGVLAAHDNDNENENNVIGSRDILASGSYDDTIRLWRDVEEEGDWICVGVIEGHRGTVWDVKWEPFINYDTLDLVGISGQDRDTAVAEFEADWQPRIVSCSDDLSVRIWRRELSEAEKAKRADRRKTTSAPTGFASSRLPSVIRPMSSMEKWVEDTILPEVHVRSVYAVDWSRRTGLVVSCGGDGAIVVYKEVVDTEASATGTAADVVMNGTTAPAGSSGETAPQPYVVRKTKWIVVAVIEAAHDEFEINHVCWAERRDRDKRADGEEVIISTGDEGDVRVWTLPDALVQKDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2Z9</accession>
    <name>A0A0D2B2Z9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-T/Histone H4 histone fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233529.1">
        <property type="nucleotide sequence ID" value="XM_016382826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2Z9"/>
    <dbReference type="STRING" id="91928.A0A0D2B2Z9"/>
    <dbReference type="GeneID" id="27335584"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08501"/>
    <dbReference type="HOGENOM" id="CLU_497851_0_0_1"/>
    <dbReference type="OrthoDB" id="10071681at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF5">
        <property type="entry name" value="CENP-T_HISTONE H4 HISTONE FOLD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="6">
        <location>
            <begin position="374"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="482" mass="53628" checksum="00D0DF691CA7F6C4" modified="2015-04-29" version="1">MSSRKRPLAELFNSQTPARHAPSTPHALYALQQRSGAMTRSHRKRRALSEDLRPDSARGILRRLAKITAPLTRKTVPTPATARGKENRESDQAETTDDGLKRSRLFLDVDDSLDEIPQPTQEEEEDSELPVPPTPSILPGDDDDSDHQNHHDPSITFQSIDFAAAPQSHEDTDRRISRISAFGAHQQNDADDDDEHTILTEIGRRAISEEPTGRLSRYSFGSLRMSDFGSELEIRRESGFQDQTNAGKLVPPYAEIAFEDGSFDVGGETEHLNQLQKSPTPPAIEESTMNIPDLDQSFQFELVVDTDVAANSANRNPAIALAGTPPVRASNDITATEASPGLEEASLQLESSIEAPELSLAPQNRRKRVKMTRHGEMVPGLPASLMKRVAIDAQARLGNRKPKLGKDHMKALEQATEWFFEQIGEDLAAYSNHARRKKRVDRSDVLMLMQRQRVLQADGELHKAARELLPKEALGEFEENEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B392</accession>
    <name>A0A0D2B392_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233286.1">
        <property type="nucleotide sequence ID" value="XM_016382583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B392"/>
    <dbReference type="GeneID" id="27335340"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08257"/>
    <dbReference type="HOGENOM" id="CLU_052827_2_1_1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF7">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G10800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="102"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="207" mass="22824" checksum="A33E4404FF76F1DB" modified="2015-04-29" version="1">MGSMPSDSETLSIYEPPDDFSREIDEHIKNCALAVELRQNPDFIESRPHLKIPAEVRQHNLTAGTLAGPGMIVVPPYYFNERDGKSMVQIFYVGPDCSGHPGIVHGGFLATMLDEGLARCAFPAMPNKVGVTANLQINYLKPTMAGQFLVLRATTTKTEGRKAWAEGWIESLEVAEGEEPQKLVEASALFIEPKYANVLKSLYRVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3D9</accession>
    <name>A0A0D2B3D9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233629.1">
        <property type="nucleotide sequence ID" value="XM_016382926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3D9"/>
    <dbReference type="GeneID" id="27335684"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08601"/>
    <dbReference type="HOGENOM" id="CLU_2291407_0_0_1"/>
    <dbReference type="OrthoDB" id="4159415at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="97" mass="10576" checksum="E5CFB4F098EA01C3" modified="2015-04-29" version="1">MNAAAQVLTRRMATMGPRLTTPVRYSSSAITHSGKMSKQERGMMRGIFGACTLATATGVLYAAARSGGRQNARFAKKRNSLDSTKWFAEGTDNRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B418</accession>
    <name>A0A0D2B418_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233904.1">
        <property type="nucleotide sequence ID" value="XM_016383201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B418"/>
    <dbReference type="STRING" id="91928.A0A0D2B418"/>
    <dbReference type="GeneID" id="27335962"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08879"/>
    <dbReference type="HOGENOM" id="CLU_055491_7_0_1"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="137" mass="15101" checksum="9C1BD9571DFC412D" modified="2015-04-29" version="1">MSDTPISPTTGKPRSKIYDGQCHCGRVQFTMKHSPPIEDGPVTSCNCSICHTNGYLMVYPLETNITWISGKNDMTSYSFGPERIAHNFCSRCGTSVGGKSTDPNFFADNRAVNIRTLKNLDVPIDELKIRKVNGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4U3</accession>
    <name>A0A0D2B4U3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233941.1">
        <property type="nucleotide sequence ID" value="XM_016383238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4U3"/>
    <dbReference type="GeneID" id="27335999"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08916"/>
    <dbReference type="HOGENOM" id="CLU_005027_4_2_1"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF22">
        <property type="entry name" value="CAPSULE ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="321"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="638" mass="71927" checksum="4700846DBA604736" modified="2015-04-29" version="1">MANLLHDFYTGGNHCCGLIATSRSLPGFNMLRLSRLSFVVGAFVLVLLYESLTYFRPSVLGNQTLSDWYSSPAGGTSASSSPIALLIADADKAFDALVAKRSETLEDAANAYRQRRGRHPPPGFDRWFEYASRNDAVIVEEFFDQIYHDLEPFWSVSPHDMRAKARNLGMHVRVHQHKAEADTGWFWHVIWANMIDEVAHLLPDMVIPLNAMDEPRIMVPFEEINARLEKAREFRVLPHHDKVSDVVQGWSEAAEPGEPQSEIEWSQSAPLSFARAACDLNSPLRAEPNMLHRAMASKNDQPRPQSFMVGGFVGNWTLASDLCQDPSIGAYHGALTSPLTKSTSQELLPMFGGSKFAVNNDILIPAPMTWNGNENFESEDPHLWSSKSVKAIWRGTATGGRHDALNWPNFHRHRFVALTNGTKYSLADETTDRIFTPLQQRSSLAGLPSEIQKNLSKWLTKYNDVCFTDLFCDIHTEEGQCWYLSDEFEVGATMRLSDQYASKYLPDVDGNSFSGRYRSFLMSNSVPIKSTLYREWHDARLVAWKHFVPMNNRFTDYYAILAYFIGCDEDTCGAAGKFEGHDSQAEQIAKAGSEWAAKVLRKVDMQIYVARLLLEYGRLTDNRRNTLGWVADLKSAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5K1</accession>
    <name>A0A0D2B5K1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234176.1">
        <property type="nucleotide sequence ID" value="XM_016381074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5K1"/>
    <dbReference type="STRING" id="91928.A0A0D2B5K1"/>
    <dbReference type="GeneID" id="27333824"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06741"/>
    <dbReference type="HOGENOM" id="CLU_009858_1_0_1"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="91"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="811" mass="89818" checksum="7C2587BA4FBBF568" modified="2015-04-29" version="1">MAPTMTSVHHHRSTTKQEHKPYKSRHASKSALKDAAKGKVESHRAHKGQRKTPHQQVMSKLTRRNQAKQMRMNHKEKREGEEHIFQGTDGAAKHIAIVPLSNTINSYAAIKALNESVDISGPDVSSGTVPVKVDRFRRNLLYLPATFDLLNALDVCKLADWVVFVLDAEQTFGEVEDSFLRALEGQGITNVTAVVKDIEAKVPAAKRSRHLTDLKISIGRYFPASDKLSSLDSKSDCSNLVRSMCTASTRGIRWRDDRSWMLIENVNWGNIDDGADSAAVTLCGTIRGKGLNPDRLVHVPGWGDFQINVIREVPRQGQKRKANEMDADVPVNEWRPTADQDELAELAPEQAEMHDVASTAATTEHKGVLLDDHHYFSDDNSHIPAPPKKLPKGTSSYQAAWYLDDVSDSDSDMAEDDNDGDVAMDAAESLGPEDGIAITNGDAMTEGGQSEYPESEMHVDADEEEEARQLEEFRASRKTEAEDDLEFPDEIELHPDVLARERLAKYRGLKSLRTSEWNHAEDAAYEPFEYKRLLQVPDYKRSYKSALNESLAGGVLAGTKVEIELRHVPVSLASAPAPASMFALLRHEHKHAVVNLNFTLNSDFDGPLKSKDEVVVQIGHRRLIINPIFSAAGQTPNDVHKFDRFLHPGRTAIATFTGPLTWGSVPVLVFRREAAAAADDVAPALVDSSAPGAPGGVSREPGQLRLIGSATTLAPSSSRVVAKRLILTGHPFKIHKKLVTVRYMFFNREDVLWFAALPLWTKRGRQGFIKEPLGTHGYFKATFDGKINPLDAIGVSLYKRVWPRAARPLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B761</accession>
    <name>A0A0D2B761_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234989.1">
        <property type="nucleotide sequence ID" value="XM_016381887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B761"/>
    <dbReference type="STRING" id="91928.A0A0D2B761"/>
    <dbReference type="GeneID" id="27334641"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07558"/>
    <dbReference type="HOGENOM" id="CLU_027095_1_0_1"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="3">
        <location>
            <begin position="380"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="546" mass="61560" checksum="FB5E41002EB3AF7B" modified="2015-04-29" version="1">MVQQVFLPNGQIYTVTPVFGGFTFKSTHLDLHHSPIPPGWTVMVQTEDVVDDDDARKSRSSVNPERNVSNNTHEKQVVVHRFMQPTAQRDSLFISSISMPSSSDFRNTASPTRHIAMILWATLCWYFHKEPPNLHTTTEASALTPESGRPKLDWRIKIRKEGIFKGKNTLQKLERMGLIASEESCVGSEMDFRQADGWADTFVSRKSFWQIDARIFLYTMAPQQHSPFPGTSPHSSRPASPDRTALPDRGSPRTTDYMLPPPQPGLVDGISAGIASPGGPFNSGSHLPTFYPPPPLQFTFTNHIRHPIRPKPPRQGETFYSRYIPSLGQWLSFRVPTLSSKPCPHPHFSPLGPSLPSVMSSHGGSISLPTLPTLANFGDRSCDLDLLHKWMNEPRVNAAWSCAGPKESQKKFLIEGLESRHSFPVFGCWDGKPFGYFEIYWVKEDKLGRLLGGDVGNYTRGLHVLVGEQEFRGPHRVKVWLSALVHYCWLADQRTETVMLEPRVDNAKFINYLKEAGFYKQGEVSFPHKQSAVMKIDRESWEAPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8Q4</accession>
    <name>A0A0D2B8Q4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235231.1">
        <property type="nucleotide sequence ID" value="XM_016382129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8Q4"/>
    <dbReference type="GeneID" id="27334885"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07802"/>
    <dbReference type="HOGENOM" id="CLU_1120203_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW15015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="214" mass="24043" checksum="49834466D1B17CDF" modified="2015-04-29" version="1">MDYTAYASAADPNYQKSLTSRSQSKVKFSATFPHKYCSVNPRQPDGPFVLKFSIKAEGDRCIMINTVAPIVGLQSVIDRDILSGLPCIVVRELHCQGHPRNQPVFSLKLDVFYLDEYHRREELSPPDFNPKDFAILGPEGYEGEYILNQPFEFLQSRVACGIMSPGRSYHLDTGPLNATCYKCNDGSCPDHQPRIKTVPVELDSFTMPVFSLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8R6</accession>
    <name>A0A0D2B8R6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235544.1">
        <property type="nucleotide sequence ID" value="XM_016379717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8R6"/>
    <dbReference type="GeneID" id="27332457"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05374"/>
    <dbReference type="HOGENOM" id="CLU_518772_0_0_1"/>
    <dbReference type="OrthoDB" id="4159699at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55448" checksum="84C0E570CB54AF4E" modified="2015-04-29" version="1">METLGGVTAIFTIANEFHNVCKKLNRFIKNVKYGHKEVDMIAHEAEIFALLLQRFGKTMRTADSPEGGFLIDLDSNRITDKIVQASQDIGDKIRHLLKKSEPLRLDKPEYSQVKRWWVALKWSTWKEEWSQIHLFLVSTKVDAELLISMINLETLMNHIRALRTNDREVPEDLKQELEASKRAIKGLRNSVKKLQKRCQRLELRGEDRLVVQLNIGLAEATRGVVRNYIETHEEIKAILNTDTPPTSAQVSNMESAGSVSHAEEANFSQSRYARTENSFAVEHGSLRRSEISGIVDDESESDLDDMGWEDGSPVEEAVEHTDSSEEFGEVAEEGRAMSEATPDGEHIIHVYREPMPEEVIEEGRRVLEEPDVPEEPDVPQEPGVPEEPGTVPGTARGEETNPTASEVENGVSFKDFTYFEELPNNKPSEQWMQSALHGLHNGRRSRRRQRPKTPEMPPGDIVVDRNDGRGAQHEYRPPRRPRDPSTAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9M9</accession>
    <name>A0A0D2B9M9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Modifier of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NCT transcriptional regulatory complex subunit mot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_05391</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity. Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms the NCT transcriptional regulatory complex with nctA and nctB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235561.1">
        <property type="nucleotide sequence ID" value="XM_016379734.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2B9M9"/>
    <dbReference type="GeneID" id="27332474"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05391"/>
    <dbReference type="HOGENOM" id="CLU_000315_1_1_1"/>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000508">
        <property type="entry name" value="Probable helicase mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000445">
        <property type="entry name" value="Related to MOT1-transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="1326"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1671"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="179"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="711"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW15345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1900" mass="210222" checksum="BA7EBB166B1B21BC" modified="2015-04-29" version="1">MATSRLDRLVTLLDKGSTQLIRNTAAQQLADVQKQNPDNLFPLLGRVLPYLQSKSWDTRTAAAKALGGILENAEKFDPNSDDADPKSEAIKSEDSSIKLEDKGIEADDLLHLATLDIKMILNYGKKLLGSAGKEYEYSMANMTPAQRLAHQKQNLTARLGLGGEYIEEDLVNEHDFAAGSQAKRTSNPGLARVDTKSGATRPDDFGSASPLTALSPSESNGHALSEEAGLSKRQLNQLKRKNKSAAKAGASKMRVVDLSVRRTSEPNQTPVSATPHAVKLNGHDEANGDSTPDYFSIKREGPDDDTALISEFKGEEMSEKPLIQPDEEHARDWPFDVMCDFLSIDLFDPHWEIRHGAAMGLREVLRVHGKGAGRRYGKSRAQNDLANKRWLDDLACRLLCVLMLDRFGDYVSDTVVAPIRESIGQTLGALLTQLPDETAVAVYRFLQQMINQTDTGLKQPIWEVCHGGMIGLRYFVAVRKDLLLQEPDLIDGVVSAVVRGLAHPDDDVKSVSAATLVPIAGELTTMRPQSLGQLISVVWDCLLDMQDDLSASTGAVMDLLATLCSYEQVVDAMRSNAEEDPEQSFESLVPRLYFFLRHTITSVRMAVLKALATFLSLSNSGNMGWVGGRVTRLIFQNMLLERNEGVLWKSFEVWQALIAFMDRQGLENFLPSLEPHITAMVKATIQPIGQPRNPIPMDISLLIKPSGAPMAAIPSKHRRTSDSDQQPKKRRKLEKTESAPVQQPSHNTDGHMLHGDVELVGMEVMLRTRIACSRALGLLLGKQDQSTISAFWASLVPATSSENSSSRLFSAMVLEEVAKHETSKPLNTSAILADLQKVLDNDGSNWYADIVSSLQAARGQCQALISAFQNNAHVPRDRLPAIAVVCQGTTGAGPKAFSLEDAERIVTTDFDRLIKGLTPAQRVSGTQYLNDARANAKAAVDEARKIKDSREMAIKATVASVFIRLGEIPKKPGQLIKCMMDSIKGEEYEDLQARSASAVAGLIDFYTASPKRGPVDKLVSNLVKFTCVDTSETPEFPPNRSFEDVVLSLRKEEDRKDHPDAARFEQEAKEARIMRRGAKRALDELAQSYGAALLEKLPILQSLIEGPVRQLIGSADPATLTVDDEQGQSLIDALSALRTLLPTLDHALYAWVLSLSPLIGKAMRSRLSVIRYSAAKCFATLCSVIPVEGMTTLVQEILPNISNPLDLRDRQGITECVYHLISVMGDRILPYVIFLIVPVLGRMSDANNDIRLLATTSFATLVKLVPLEAGIPDPPGMPEALLQGRERERKFMSQMLDPKKVEPFQIPVAIKAELRSYQQDGVNWLAFLNKYNLHGVLCDDMGLGKTLQTLCIVASDHHIRAEEYAKTQAPDMRRLPSLIVCPPTLSGHWQQEIKQYAPFLKCVAYVGSPAERSSRRNLLEAADVVITSYDVCRNDSDVLTPITWNYCVLDEGHLIKNPKAKITQAVKKIVSNHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKVFQDRFAKPIAASRNAKSSSKEQEAGALAIEALHKQVLPFLLRRLKEEVLNDLPPKILQNYYCDLSDLQKRLFEDFFKKERKTVENSVGSSDKEAKQHIFQALQYMRKLCNSPALVVKEGNTQYDTIQKQLAASKSSLRDVAHAPKLSALRDLLVDCGIGVTSDSNEMSASNYVSPHRALIFCQMKEMLDMVQNEVLGKLLPSVQFLRLDGSVEATKRQNIVNQFNNDPSYDCLLLTTSVGGLGLNLTGADTVIFVEHDWNPQKDIQAMDRAHRIGQKKVVNVYRLITRGTLEEKILNLQRFKIDVASTVVNQQNAGLGSMETDQILDLFNLGETSENGPEGAASGKDEDMVDMATGEVKKKGEKGWLDDVGELWDERQYEEEFNLDSFVQNLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9Q2</accession>
    <name>A0A0D2B9Q2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235576.1">
        <property type="nucleotide sequence ID" value="XM_016379749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9Q2"/>
    <dbReference type="GeneID" id="27332489"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05406"/>
    <dbReference type="HOGENOM" id="CLU_419790_0_0_1"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238886" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="69528" checksum="CC3634A59047C329" modified="2015-04-29" version="1">MATHSLGVSIILMLYVSTLLNLVQAHPRDYLRHVHYQLPGTDMPTSTNNPPNLARDVTSNMPVLPCLNGPCATAIPPLEKLSCYAVNGTVFFNNATNYTLLCDVDFPAQNIYPFVLAGSFSECLEQCESFNRKNVSGTRCVGFVFAADRLHDADDCYLKSSLNEPIPATIHLVGATMATSTSACTKTPKSNSETRSMLSSSGSALTVKDFRVLGSSTNKPTTQYVSHVPATPEKLSSNVLIPGINVDLITKYPIAGDTGVWCEGNIPLNVNVADMKVVPHMSRDGGKGGTINGTHLFVFCDTASFQIDGTSNPLVGFVSSSVATDDGMKALYGQALDLVDHLGEWQDDVGRLRGFAPMTTGEESFNIALSGNGYRYAVWPESSLIPLNRSHALLYPALVYDVVNMKTQAAVFHDLGSTILLVSVDEKYGPTAQRLVPQLFKQDQVTFGTLGGLRSWGSSGVGGNDGVIYLFGETDHGVLVARTTPDEFTSLSSYTYWDGSAWSSNMPSPKSTATMIDVPVQDLDVFYVPALRSFVMIYLNTVADNTFYYRHLPLDLDVDENGDYQHIITSQWSEEGVLAKIDAPAEGYMYAGGMHAGYFGDDDITNGGWKMLITWTEHTGKDAASPESGYAHKSAYVELGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBZ1</accession>
    <name>A0A0D2BBZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236351.1">
        <property type="nucleotide sequence ID" value="XM_016380524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBZ1"/>
    <dbReference type="STRING" id="91928.A0A0D2BBZ1"/>
    <dbReference type="GeneID" id="27333269"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06186"/>
    <dbReference type="HOGENOM" id="CLU_007315_0_0_1"/>
    <dbReference type="OrthoDB" id="41200at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="158"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="522"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="857"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1074" mass="117104" checksum="E97ED1A4F1DFE73C" modified="2015-04-29" version="1">MSTMEEQPDPVKTPEDTLAGPIPITPVNPPTTQALTTTSAIDATLRFFANASNETLGACAVGLCASTYLVLGRVGLVLIGAVGGIVLHATWDSQQSEGPNSEKGEAARRKKELGIEVAHRLLDWRDKRKTGDKAEDISDDGEIDTVADAPTLDFSELPPETSKSLTSLADAVIRDYVNYWYTPLLPKEQSFPLICRQTLTSFIISFSRHLSRKRAADPFLDFLSNSTSIVIVFLSELSSALKASPSREAETAVKTYLQSQPDSNLANVLSRDQQDRKLTLVADDILHNFLDSKSYNCPPVKTFLRQILAGLVLESTIEACSKPEWINQWIVYLLEDGEPEILKEIDAGVEDMGEAMAKAPQDQKSPQSHKRRVSRAEEAMQEAMRQAQRLNEMIAEDEARRKRGLPPNEPEETSSVATTDAGMVTPTSSDSDRNRPKSLLDTSLVFDIDGNVVQSTLPSPNKSAPETPNRSTPVTPNKELSQFTDFAQLGENVLAPPQTVSSAPTPVEVMVAVPLTLQNASIAILDLGNGNEKAKLKQRPNNEYLLQIEPASHRYPGWMVTRRYADFERLHQTLTIIARISGVPEFGQIYSTLPAWKGETSAALLRSLEQYLSFCLKFEPLAETEVMKKFLDKETGLQKAPAQSKNVLVQGGAALENVGKNFINVLGQGGKGIAGGGKAVLGGVQGVFGAVATGVGGGPKRPRRPSRQPSRTDSPSTPNHQSTQEIVSGSSESLDLKGPPLPPRPRTDSVCTDQQSVPAPAPEPSPLREKNMDLPPPPSVIPDDYSPVTPFKPETPPTSPRPRQDTIVAKPVTPSPARIVEEPELEPEPEPEPEPEPEPEPAPERAPEPEPAPAPEPEPEPEPEPEPEQESVPEPELEPELTPEPAPEAEAPATPSLSQTPSRRPRQEDAPISGEETRICIELLFAVLTELYSLAGAWSLRLSLLGAAKTFLLRPNNPQLESIRVLLQEGVLETHFSDKGLAAHIDKLRKNTLPTPEEREKWPKELTAEEKEKLRVKARKLLVERGMPQALTSVMGAAASGEALGRVFDCLQFQHVARGLVFALMLQAIRATTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDA7</accession>
    <name>A0A0D2BDA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Initiation-specific alpha-1,6-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236791.1">
        <property type="nucleotide sequence ID" value="XM_016378114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDA7"/>
    <dbReference type="STRING" id="91928.A0A0D2BDA7"/>
    <dbReference type="GeneID" id="27330846"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03763"/>
    <dbReference type="HOGENOM" id="CLU_022381_2_2_1"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000004">
        <property type="entry name" value="Glycosyltransferase family 32 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44331" checksum="546195A35223C2D6" modified="2015-04-29" version="1">MQSATTPVLGGCLPKQIRRALPVCLVLVLLALVLMTAGSLGEFSAEVSYHASMASGRFPRKIWQTWKVDPLDFEERDLTTARTWIMKNPDHRYEVLTDQNDLYYVETYFGPAGFNRPDIVHTYKSLTARIVKADLLRYLVMYAEGGVYTDIDVEALKPIERFIPSRYNEKDVDMVIGIEIDQPEFHNHSILGGKCESFCQWTFMSKPRLPVMMRLINNILKWLNEVSRKQGVPISDIQLDFDEVISGTGPSAFTRAIMEEMAVRTGEAVHWDCFHNLGESKLVGGILVLTVEAFAAGQGHSDSGNHNAKTALVKHHYHASGWPTTHPRYTHPVYGEVERCNWDADCVREWDENKAAFDALSPEEQANQIAMKEAADAALLSAETGFPAEGQLTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEP8</accession>
    <name>A0A0D2BEP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">PV08_04251</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237276.1">
        <property type="nucleotide sequence ID" value="XM_016378599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEP8"/>
    <dbReference type="STRING" id="91928.A0A0D2BEP8"/>
    <dbReference type="GeneID" id="27331334"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04251"/>
    <dbReference type="HOGENOM" id="CLU_036911_0_0_1"/>
    <dbReference type="OrthoDB" id="2160599at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW17060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="305" mass="33902" checksum="EE53C3E7FE6A571D" modified="2015-04-29" version="1">MADDTDQHRDKRPRLDDDGNTDRIEGGAFPTATNHDRQDSMDVDVDEDRGGQVVKTPGGIAAGEMTALEQLQEDMGEPFLLCRSKVERQKPDPQQHLLALYGLGPLLRTVARTDPRTGEKINKLRKSYEGQIKSFGLAGRNKPVKGERNVEEDQPGPLRRMAGSSAWGLQPEEQWNAEHATPKIEVTPDFRAKLKQAMQMQPGTVRNNAYWEDILGFDKPKPNALPPQQKSHPPTPVHVSNGISRQPAQPTAEAKRQTRGKKRSYGDDSFVGYGEGFSDQEDGVDGDDYGGQRKRKKVMMTTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BET0</accession>
    <name>A0A0D2BET0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_04306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="8"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237331.1">
        <property type="nucleotide sequence ID" value="XM_016378654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BET0"/>
    <dbReference type="STRING" id="91928.A0A0D2BET0"/>
    <dbReference type="GeneID" id="27331389"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04306"/>
    <dbReference type="HOGENOM" id="CLU_044118_1_2_1"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000012">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="326" mass="34465" checksum="CD10B1CE1A074DD2" modified="2015-04-29" version="1">MSARSTTGGAGQGEDIDLVLLRDHLVSIALRAGRMITSARPSTSSSGTKKNSADLVTETDQAVEAFISSELRTLYPGFSFMGEETYQPGQTLGPEPTFVVDPIDGTTNFVHRFPYVSVSLGFAVDRVPSVGVVYNPFTGRLYTGVKGKGSFVFDVPAGAGAAGAGDLTAPPRPEQGTKLPTKELTALGGLDGCVVAVEFGSDRSGRNWKTKTDTWARLGRSKDDGGAMVHSARALGSAALNLCGVAEGVLDAYWEGGCWAWDVCAGWVILTEAGGLIVDGNPSGNFDIPVTHRKYLAVKAAKDGVGQKELVKEFWSHIEGDMVYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFD3</accession>
    <name>A0A0D2BFD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PRP1 splicing factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_11805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230245.1">
        <property type="nucleotide sequence ID" value="XM_016386113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFD3"/>
    <dbReference type="STRING" id="91928.A0A0D2BFD3"/>
    <dbReference type="GeneID" id="27338888"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11805"/>
    <dbReference type="HOGENOM" id="CLU_007010_0_0_1"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001164">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative (AFU_orthologue AFUA_2G06070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000304">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="708"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="843"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW10029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="945" mass="106214" checksum="E4DBC764290D808A" modified="2015-04-29" version="1">MASRRDFLSQQAPENYVAGLGRGATGFTTRSDLGPAREGPSAEQIQEALAKRAAQLGAAPPTAYGATGKKPEEPEDDDERFQDPDNETGLFAFGQYDRDDDEADRIYQEVEEKMERRRKAQREAREREEIEEYNRKNPKIAEQFADLKRPLATITDEEWANLPDPGDLTGKNRRSKQNLRQRFYAVPDSVLAGARDSTELQTTVEDDGADTAVSADTKDGTMTNFAAIGVARDKVLKARLDRAAQADAGTGTATAIDTKGYLTSLNTAEFKASELAVGDVKRVRVLLESVIKTNPKHAPGWIAIARLDELAGKIVSARKLIAQGCEQCPKSEDAWLENIRLNDNHNAKIIAANAIKNNERSTRLWIEAMKLESDPRAKKRVLRQAIDHIPQSVAIWKEAVNLEEDPEDAKLLLAKATEIIPLSVELWLALARLETPEAAQAVLNKARKAVPTSHEIWIAAARLQEQMGNAHKVNIMNRAVKALVKEGAMLKREEWIAEAEKCEEEGAVLTCGAIIRETLGYGLDEDDDRKEIFKDDAKASMGRDRFETARAIYAYALRIFPTSMSLWIEAADLERHHGTKEALWQVLEKAVEACPSSTKLWLQLAREQWYAGNVDDARRVLARAFNQNPKSEEIWLAAVKLEADAKQVDQARELLSTARQQASTERVWYKSAAYERQLGNIDVALDLVLQGLTSTVVDKKETRFPRSAKLWMIKGQIYEDKGMIPQAREAYSQGTRAAPKSVPLWLLAARLEVKAGIIIKARSVLDRARLQNPKNPELWVESIRIELNTKPPNIQQAKTLMSKALQECPKSGLLLSENIWTLQPRTQRKPLALEAIKAVDNDAILFVTIARIFWSERRLDKAMSWFEKAIVLDPDLGDTWAWYLKFLMQHGTEEKREDVINKCIATEPKHGEVWQRVRKDPKNAYLSTKEVLMEVTKKLEAKDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFU5</accession>
    <name>A0A0D2BFU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_04659</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237681.1">
        <property type="nucleotide sequence ID" value="XM_016379004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFU5"/>
    <dbReference type="STRING" id="91928.A0A0D2BFU5"/>
    <dbReference type="GeneID" id="27331742"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04659"/>
    <dbReference type="HOGENOM" id="CLU_076902_7_4_1"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000037">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="17">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW17465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="93" mass="10059" checksum="F37FDBB19AC612D7" modified="2015-04-29" version="1">MENHSAPAEPKDPASFLSSIIGVPVTVKLNSGLVYKGELQSVDGYMNIALEKCTEYVNGQLRRSYGDAFVRGNNGESPVVGHGMEQVFKNARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHA1</accession>
    <name>A0A0D2BHA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230945.1">
        <property type="nucleotide sequence ID" value="XM_016384343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHA1"/>
    <dbReference type="STRING" id="91928.A0A0D2BHA1"/>
    <dbReference type="GeneID" id="27337111"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10028"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="52"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="247" mass="25553" checksum="129F58D4BB938721" modified="2015-04-29" version="1">MCHKLAENVTFEQGALAEPLAVSLHAVNRSQAGGAGFGTLAGSNALVLGSGAIGILTATVLAISGVTNIVIADIDAARLQLATTLRGGKYRFKTFLLPRKAPTSTIEEGLTDAQELALNISRSAHLETGFDRVFECTGVPSCVQLGIFAATAGGKLILVGMGSATQTIPLGAAALREVDIIGVFRYANCYPTALALLASGNLDGVVEELVTHRVELADGEKAFRLAANQGRPGEDEGRVPIKVVITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHY1</accession>
    <name>A0A0D2BHY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238739.1">
        <property type="nucleotide sequence ID" value="XM_016377169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHY1"/>
    <dbReference type="STRING" id="91928.A0A0D2BHY1"/>
    <dbReference type="GeneID" id="27329894"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02811"/>
    <dbReference type="HOGENOM" id="CLU_103537_0_0_1"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43058:SF1">
        <property type="entry name" value="DUF427 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43058">
        <property type="entry name" value="SLR0655 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="163" mass="18567" checksum="74AF3F7312E9B744" modified="2015-04-29" version="1">MSARPKLIVQNFPRPPLLEQIPRHLLIRWNGHALADTRSSFWVLETTHPPTYYLPRDSISPTFKLSQAPGRASLCEWKGRATYWDVTNQSTGEIVKGKVWSYESPTPAFKDIKGFLSFYANDVPWECFVDDEKVTPQEGDYYGGWVTSELEGPMKGGPGTWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIR8</accession>
    <name>A0A0D2BIR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_10554</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231470.1">
        <property type="nucleotide sequence ID" value="XM_016384868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIR8"/>
    <dbReference type="STRING" id="91928.A0A0D2BIR8"/>
    <dbReference type="GeneID" id="27337637"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10554"/>
    <dbReference type="HOGENOM" id="CLU_018142_0_0_1"/>
    <dbReference type="OrthoDB" id="5413466at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01044">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="124"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="221"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW11254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="674" mass="72545" checksum="DAFD8B10B32FEDFC" modified="2015-04-29" version="1">MPALRRKDLLSRRRRRADEGEDDGSIAGDYDDSSSEDSAVSDGDDEAEAEGSESSGDEHEPTKSAAGRKAIITEQENQRSAVNIPQESDATSNGAFTTSAETQAMLHGLGRQQHPEEMEQVDFDDLHAGDDAASESAAAAPRATRNETPAQRSLREHQEYIQQRNTNPAFVPNRGKFFLHDDRTAASNGALSRPLFRGRGRGYASPMNAGRGFGINEPTDRPWAHDLHEGHELGPSPVPSQTQPVPGERTTRARNSPAAALPNRSFSFTTVLGNVSVQISFPGMEKKKIVSNVVKKHHTLLPQHRPPLRRDKPVRISIPDQQAKYVFPSTERSFIFIPRAMRPNQQNYHRGRGRGSFHGSRRPSVYGSVYTPSIAMSRKSSIGGSTMRDGIRSPADSVISRMGASGMEFARPIVRMPSGVPTPSVSRTGMPIVNGPMGLNTVPPNIPPPPFYGSHSTAIPMHQPRPQKTVSVADIESPAAYSVKAPQQQQDLPFHQQVPAHMAASQADERVPPAPQTLPGMAGTTPLSQIPEGAVFAQGFQPYPVMGGPGYFTTPYANGLLYYPGMGGNGSFSVPITGPAMAPSFIPGSQAHPVNYVHAPGPAEGGTGNNLMAHESNGMVYYYNPPAYPTDSQGGFQQYPSVAGNVMPMANGLPSQPLYYPGVSNGMFYPAQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ10</accession>
    <name>A0A0D2BJ10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_10639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231555.1">
        <property type="nucleotide sequence ID" value="XM_016384953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ10"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ10"/>
    <dbReference type="GeneID" id="27337722"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10639"/>
    <dbReference type="HOGENOM" id="CLU_076723_0_1_1"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000389">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="46"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW11339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="242" mass="27165" checksum="FBF9B2340F4B923C" modified="2015-04-29" version="1">MPQGLDKCKERPESIDNILNGLDRYNPETTTTFQEYVSQQCEEKFFDTYASLALLKLYQFNPQLLHPETVTNILVKALTVFPSPAFSLCLALLPPSTIPYQPGNTSIPTTDFTESIQKLTRLNTLLESAQYDAFWSTLESDDLYADLYADVAGFEDLVRIRIAGEVGKTFRQIDLSVLSSWLDLRGEALVKFAQTACGWKVNGQQVEIPSNAENEAKSEIKGERVGVDMFGRVFRRGYEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJB5</accession>
    <name>A0A0D2BJB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239204.1">
        <property type="nucleotide sequence ID" value="XM_016377634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJB5"/>
    <dbReference type="STRING" id="91928.A0A0D2BJB5"/>
    <dbReference type="GeneID" id="27330360"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03277"/>
    <dbReference type="HOGENOM" id="CLU_005053_2_1_1"/>
    <dbReference type="OrthoDB" id="5300331at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="372"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="843"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="894" mass="98967" checksum="014FA2083B23F7A2" modified="2015-04-29" version="1">MAKRISSIFSLSLTRDDKAYEQPHAHASHYLQSEPSANPGEGGPHKLHKHSPAASSDFSIENDLPPLMPPPFVSDEGVFRPPSSQRSGPDSRLGSRASSPASLTLVQSREESRSRPQTPVFPASPGTSAIHSAGPPSAVPSGRIKKKSWALTKPGGRNNGEGYAQAWIAGLRELIPYDLTPLMKGEKVPEAWSDQGDTLIYLYPPSSKKGPCFKVHSSLLMDSKTLVNLRFACPTSPVENDDDLQQLQLALAELTTTSQGIRPSSQASSTASRPSLNFSVPSANTFVNDQKHVYLPLGFDTDLSLPGTEPQGNDLELVVLYRNFFAFLAGGALVATPRQVTVFSIMMGISTILKRFSFTNSDGSTFGEVPTSSFARYCEELRLGDVRSSREKTIEAIVLGEQLRSWLLYNEGFTHAVGKLADIKAIKSPKFEKITSTTVARLERAQLELEQKLVNLTGKLNDFDFPSMFAGIANSQSSTEAKMIRFKEWKAAFLDLRKFTLSYYRRRYGSWPPKASSKKNNFEENGLNRVLLKELYKDFTDLYDILVDRTSPTTRTANMPPMADDAETSDLNETIQHAIRRVESEYDRATPPVLPPMPFDTPLLPQFSHSFNRTHVVISDKTALQSKKLRENEVNEVLLGSYNRTSINASPFIQEFFGYERRLGHGKVLDQIVDARCGQWLFLYAVLQALPLVVVDARNLKYTDGVEYFLCIAPRGRPWMKEDSSGFRSLSFVDKSGVAVDWTAEQIDQSVETIYARSHCWTAATAWVHAKEDEGQQVHLGRTSSPRILPLDPPIAPPQYLNPPESPYLSPYASPLLRPSSPTYSDVRSVSHDRSSVSLGLEPAHASASRSASRPTSTLSHQAIQFEADPNMTFDTILGTNESPQKTKGKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKG3</accession>
    <name>A0A0D2BKG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239256.1">
        <property type="nucleotide sequence ID" value="XM_016377686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKG3"/>
    <dbReference type="STRING" id="91928.A0A0D2BKG3"/>
    <dbReference type="GeneID" id="27330413"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03330"/>
    <dbReference type="HOGENOM" id="CLU_035914_0_0_1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239173" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="374" mass="41079" checksum="5E26DCB97B671E8D" modified="2015-04-29" version="1">MLRSLLPFVSASALLASVVSAIPVNTHHARSPSAEWDEWTCTADNIRTRVDFNNMAPADRKAYTDAVKCLMAQPSQLDQTLYPAATNRYMDYAVIHVNRTQHVHLDAFFLTWHRYFLWLYESDLQQTCGYTGAFPYWNFAETANDPHSYPIFDGSDYSMSGDGLYNNTGPIVLGAELTIPHGTGGGCVTTGPFANMIAPLKFIDPTALTTGTLPDDAFAYNPVCLMRDLNAYVSQTYTNSAQLVAAAHATNASNFEYLLNGVIGSSSLGIHSGAHFSVGGQMNSIHVSAQDPIWYPLHTMIDKVYTSWQINYPELADTLDGSTGTALNTPPSDVVTLDSIEPDWGYFQLGQIQVRDLISTTSGPFCYQYDTVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL02</accession>
    <name>A0A0D2BL02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_09187</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232130.1">
        <property type="nucleotide sequence ID" value="XM_016383507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL02"/>
    <dbReference type="STRING" id="91928.A0A0D2BL02"/>
    <dbReference type="GeneID" id="27336270"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09187"/>
    <dbReference type="HOGENOM" id="CLU_037994_1_0_1"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000041">
        <property type="entry name" value="37S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="237"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW11914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="400" mass="45427" checksum="1B6A19A6E5C83D03" modified="2015-04-29" version="1">MSVARSSECVFCLFSRPSRPASIARRRFHSSPIHQKRKPRFPSVKAAVNEIDLNKAGKDLLNPEANKDYTSQNYTPEQLAAIKVAQKLIDPEKLYRTTSNRKDPWRVKYYDDLAKIDPVVDKPVQHPWTNLDDNSRLKTDEEFEDDLVKLMHEIPSPRNEDDFDTALWDKFDKNLRLTVGKEEAERQPRTAMVPDLPNISPPPPKGNQARGKFDQESPALATLMHMTGLDRQALLQLRVKSVVQRTVANQTRLGKIRKTYWLSVAGNEQGMIGIGEAKGTEPGEALIQSQYRAIRNMKPIIRYENRTTYGDLSAKVSGTELELYARPPGFGLRCQKYIWEVCKVAGIHDLAARVTRSRNPMNTVKATVQALLGQKHPEDIARARGKKLVDVRKVYYAGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL30</accession>
    <name>A0A0D2BL30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_03599</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239521.1">
        <property type="nucleotide sequence ID" value="XM_016377951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL30"/>
    <dbReference type="STRING" id="91928.A0A0D2BL30"/>
    <dbReference type="GeneID" id="27330682"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03599"/>
    <dbReference type="HOGENOM" id="CLU_007818_2_0_1"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239097" description="chitinase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="171"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="404"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW19305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="548" mass="57893" checksum="3E8267486A7B96EC" modified="2015-04-29" version="1">MPCSRFFLIPILCLVNVYANLVLASGSEWNDDIAKRAHDPLNTIESKQEHHFAGLGPRDSAARSSYWKPLRLSQREPPSDFEAQLADVANQLTSSLNTLWALIQREYNIGPPVIASGSSHPTVYPITFANSHGSYPTPGPSSTPTAAASSSSSSSQQTPSGTYAFNPQASDLNIVYYSQTDLTKTVTLTQVCSDPSVDVVILAFITSLFGKGGYPSMNMASNCWAPSAAQQNAGATGLLDCVGDGFAVQISSCQSLGKKVLISMGGIYSNLQISSTDQATQAAQLLWNLFLGGTDAATAPLRPYGSVVLDGIDLDNENPSNAQYMPSLMAALRTLMATDSAKSYYLSAAPQCPQPDQSILVPGLLDVVDFFNVQFYNNPSCQLGSGQGFLDSLTSWSSSLLLPAVHGGPGPSSRPRSPPRRKRSRASLSTRRTQIPPASFGDAAPGASSNGGGGGDDDNDDNTGFMNINNGVTYPRLLVGTPAFGAAGTGYVTVAQYKDILEQVKALRLPNVAGAMFWDGAYEIRSGAPVDGAGTNKTYVQVVRDVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL84</accession>
    <name>A0A0D2BL84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232180.1">
        <property type="nucleotide sequence ID" value="XM_016383557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL84"/>
    <dbReference type="STRING" id="91928.A0A0D2BL84"/>
    <dbReference type="GeneID" id="27336321"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09238"/>
    <dbReference type="HOGENOM" id="CLU_004759_5_0_1"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000697">
        <property type="entry name" value="WD repeat protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="274"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="555"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="841"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="722"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="867"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="915" mass="100766" checksum="197BCCE42BF15C75" modified="2015-04-29" version="1">MSPVLGSLEGQAANAAQGMVLDPISRQILERTQSSNKLPSGQQSGVVPSKSTYADPGPSEDLYSGRMSSDPAPLRRVDSGASNKLTKDKKKGVSFLSRIMGGPKKRDVFDVREDTISEFADDRSPGVEAEVFSQPLGHIPKFPAPPRYIKVKTQHRKEKELDRLFLAQIALEAPKPKSRRRLSIDSKIHDITDNPTSPSTTLTSTGNSAIWAMEFSKDGKYLAAAGQDKKLRVWEVISSTEEREFEEKLAESGKDGNKIKLNAPVFKTKLAREYDGHTSSVLDLSWSKNNFLLSSSMDKTVRLYHVSRAECLCAFKHNDFVTSIQFHPRDDRFFLAGSLDSKLRLWSIPDKTVAFWAQVPDMVTAVAFTPDGKTAIAGCLNGLCILYDTEGLKAHSQIHVRSARGKNAKGSKITGIDTIALPRDNANTDVKLLITSNDSRIRMYNLKDRTLEVKFRGNENTCSQIHASFSDDGKYVICGSEDRKVYIWPTSEHERPDNEKRPMEVFEAHSAIVTTALLAPERTRRLLAQSGDPLYDLCNPPPVTLFSRADSVISSRAPTNNSSDEKNPIFENRLSGSPKRAPESPAFLARHSHPGGQIIVTADYTGQIKVFRQDCAFQKRKHESWDAGSSFSRKMLGRSASVNTRTSGTSSTHRNSFVMGSKTQSTDRILSWRNSVSATAGGNPPSASLVEIRGSMSSERSRSASPKKLISHRLSLRKASPPTKNGILSPTSPTFHSPLNQMQNGPSIAVTSPTASSHTQKTPDYEKHFSPTDFQPIRTNPSPSDLPHNDPLLLMDQQSFLAWDIRNTLLPMAKHIPRTPGVLGPDGNPLSRAESYVSQLSSEIAASDQEAHSAGASVDGDNERARNNRKSRSRRRSSASSEGELRCRNCRGKAFKVTMGQKGQTFRCKKCGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLE6</accession>
    <name>A0A0D2BLE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate carboxypeptidase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239611.1">
        <property type="nucleotide sequence ID" value="XM_016378041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLE6"/>
    <dbReference type="STRING" id="91928.A0A0D2BLE6"/>
    <dbReference type="GeneID" id="27330773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03690"/>
    <dbReference type="HOGENOM" id="CLU_005688_2_0_1"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="191"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="384"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="635"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="84847" checksum="852D26EF181C8596" modified="2015-04-29" version="1">MDEQTPLISSVRVERRTRRYHHSVIRRFCTVALSSILIVIVICFFLPFALLPRGHDSLTAYLPWSRLFPKAWPQSTGITYSELQALLLETPNEDKVRAWSKYYTAGPHLAGKNLSQAIWTREKWEEFGVKSDIVAYDVYINYPVSHRLALLQGDKVEYECSLEEDIIDEDPSTALQDRIPTFHGYSASGNVTAPYVYVNFGTYQDFEDLLAANISLAGKIALAKYGKIFRGLKVKRAQELGMIGVVMYSDPQEDGEITEENGYKPYPEGPARNPSSVQRGSTQYLSTLPGDPTTPGYPSKPGVPRVDPNGSTPKIPSLPISYADALPLLKALNGYGPNASSFSDAWHGGGLGYKGVDYYIGPSPSDLTLNLVNEQEYVTTPLWNVIGVINGTVPDEVIVLGNHRDAWIAGGAGDPNSGSAALNEVIRSFGEALKAGWKPFRTIVFASWDGEEYGLVGSTEWVEEYLPWLSSSTVAYLNVDVGSRGKHFDAAASPLLNKLIYNVTDTIPSPNQTVKGQSVGDTWSGKIRTMGSGSDFTAFQDFAGIPSLDLGFGSGPKDAVYHYHSNYDSFHWMDKYGDKDWHYHVAVTKIWALLAAQLAESAVLPLSAKDYAQGLGNYLEDVKERSKKSLISSSFSFQHLDKATAKLHHAASHFDAYTTQLKDRLGEDIPWWKWWKKVRLYYEVRRVNAKYKLLERQFLFPGGLDDRSWFKHVVFAPGRWTGYAGATYPGLVESFEDNNTTNAERWSEIIVDRLHAATSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLL9</accession>
    <name>A0A0D2BLL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Magnesium and cobalt transporter CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239676.1">
        <property type="nucleotide sequence ID" value="XM_016374400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLL9"/>
    <dbReference type="STRING" id="91928.A0A0D2BLL9"/>
    <dbReference type="GeneID" id="27327115"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00032"/>
    <dbReference type="HOGENOM" id="CLU_041307_4_1_1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46837" checksum="B830A3B190946308" modified="2015-04-29" version="1">MSVYHDGTHHGAFKDLLDHSGAPTMSTDEYKIAVLDVALSSTGEFSRSSLGFTTTSTLVKGQAPALRVIFAPLDYPDSGTASTLLTLFEHFSIPTTFLYERVQSVTHSFGHEELDNGAFRSWFHFLCKAIEPKHDNILWLRSAYFLRRDEHGLLTLICFGASNPLVQRLESLPKSVWDIVLTNPFNLFNTILADLHRQVDEQLWTLNRYHAIDSTVATSDFDQNWVELHYIAKNIIHIKEAVDAVLRTISHIVRAQSEGGVAGTAETRKTNLALHYSESLFESVDLRAISMEKRMQNVINLSFNLVAQKDSSRIKTESSSMHTIALTTLIFLPISTVASIFGSAFFDFNGGNTEDMSLSRHFWVFWVISVPLTVAVLTVWIYFHPSNVWRWPGLKRTRKFDRDAYQMLDLTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLT9</accession>
    <name>A0A0D2BLT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232360.1">
        <property type="nucleotide sequence ID" value="XM_016383737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLT9"/>
    <dbReference type="STRING" id="91928.A0A0D2BLT9"/>
    <dbReference type="GeneID" id="27336502"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09419"/>
    <dbReference type="HOGENOM" id="CLU_004184_7_4_1"/>
    <dbReference type="OrthoDB" id="4161734at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="46"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="605" mass="68063" checksum="FD84B22D9B97CEDD" modified="2015-04-29" version="1">MPPTLALKPISSDRFRLLTANLNEKTGRLSFKTEVHSLAGNLVPPYVPISYTWFGPPTPDDTTVDSADGVIPQSFPDQVIVDDTSVDVTRNLANALRRVVQREWPLRAKQLGLKRRLRLWCDYLCIDQTNSTEKGEQVQNMTKIFGSASKVVAWLGTPPDDEEASCAMQLLSRLTATYKENVASGKGWAADIYKKHHDIWPSHSDWSLKAWRGLEALFKARYWSRGWMLQEITAENGTTFLWGDHHFGTDEFSMVVTMITELQNFPQFTDIIQIDRFCVGNIYLLMTRRKGPDQEESFELLRLLSLLRSAECTDARDKVYAISGLAKDVEIIPRYDRYNESGVDLFLNTAVSIIDVMHVQEALSYVFVPYTEQQRRICQPPIPSSWVPDWRLRTHCQKFTGGDFYTAGGPRWSCKASVAGDELQILGFRLDTVASLSVTYETEDPTYSVIQQWREILPRNGVYKLTGEEMESVFVTTVVADCILTNSVSSRGARADFEFLERARETMDPDMTSQRARMQAALGICLGRRLCVTRAGMVALVPAATEIGDSVCVLQGCGRCHVLRLEPDGVKGSYVGETYCHGMMDGKGTAQAYAESRKPVSFRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMB5</accession>
    <name>A0A0D2BMB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_09606</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232545.1">
        <property type="nucleotide sequence ID" value="XM_016383922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMB5"/>
    <dbReference type="STRING" id="91928.A0A0D2BMB5"/>
    <dbReference type="GeneID" id="27336689"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09606"/>
    <dbReference type="HOGENOM" id="CLU_026582_1_0_1"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW12329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="359" mass="41249" checksum="39318B2AC6897489" modified="2015-04-29" version="1">MSNKASKSKSKSSKSREPYYAVSPQWKDVTPIPLIDGPPGQKDPGPALATIAYSPRYSEAMSYLRAIMAVNEFSRRALDLTEDIIGMNPAHYTVWLYRAKTLKVLWELEGTSVEDGVKVELEWLDGISQRALKNYQIWHHRQLLLSLVPAMPDAEPEFLAHILSFDSKNYHVWTYRAWLCRRFPDPLLNTEMELDALDALISEDVRNNSAWNHRYFVVFGAEELRVIEEQGGNRKDVLANGSLVVDEDVVEREINYTKDRIAWAPQNPSPWNYLKGVAKRAAIPIGEFQVYCESFVGGRKADLMGDQVRSSHAIDWLAEIYKEHGDLQRSKACLDALGQKWDPIRRKYWEYRARQMGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMX5</accession>
    <name>A0A0D2BMX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240514.1">
        <property type="nucleotide sequence ID" value="XM_016375238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMX5"/>
    <dbReference type="STRING" id="91928.A0A0D2BMX5"/>
    <dbReference type="GeneID" id="27327956"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00873"/>
    <dbReference type="HOGENOM" id="CLU_038384_0_0_1"/>
    <dbReference type="OrthoDB" id="4838853at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="302" mass="34342" checksum="518775B272194175" modified="2015-04-29" version="1">MVRPLGLKSEKFKSLAHGDRRRRLDAPPPLPFDLRDHKISISIFVFLALAECCFLPIGLYYGLIYGSNLRMGLIFAIITSLFGFVSGYEFGLRSWRIMRYGDDFRPLYGSQYFRGFDATQYVLLTPFTVMTIILIIFSIPHNPSVKALSLPMPVGMINLGLMFIVNGVAAQRRWRLMHFRLSSHVRNTVCPPLTFVFMEDICAVDGRGGKKYRKAALARYNASPQFRTLLMEVLWFWSISAVVIGAALATVIWFVSDHVAWSLGWGVPSLWALVGTWLTILWVQRGLRIEKATWTPVQANQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN15</accession>
    <name>A0A0D2BN15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_00525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240166.1">
        <property type="nucleotide sequence ID" value="XM_016374890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN15"/>
    <dbReference type="STRING" id="91928.A0A0D2BN15"/>
    <dbReference type="GeneID" id="27327608"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00525"/>
    <dbReference type="HOGENOM" id="CLU_023643_1_1_1"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW19950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="411" mass="45247" checksum="9F58E855A8E01753" modified="2015-04-29" version="1">MSRPLMRIPYTQPLPPPLIIPPSAATKQGAITALHHFLTSSGAATSENGQVQDKTVLLTGAGISVASGLADYRGQNGTYTQNKNYRPIYFHEFVASHEARKRYWARSFLGWRGLHRSSPNATHFAIRDLGRLGLVDSVITQNVDSFHRLAHPALHTVELHGYLRSLVCLSCRTLTDRDAFQARLAELNPAWAAFLQELLASGALDTEDPVERRKRGFRTNPDGDADVPGAPYTTFRYPACPSCLKRPPILSDGSKGHVDVDRDGAWVPSPRPTGTNGVGVLKPNVIMFGESIPAAVKTEAEAAIDAAGKILVVGSSLATYSAWRLVKHAHERGMGIGILNMGGVRKEELFFGEDRHHGGDGVQNSLSTSRRELVRASLPAEDILPAVVELVQEHRRRQHHHHHHHHHHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNZ8</accession>
    <name>A0A0D2BNZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="9">HIBADH</shortName>
            <ecNumber evidence="3 9">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_08026</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3 9"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233055.1">
        <property type="nucleotide sequence ID" value="XM_016382352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNZ8"/>
    <dbReference type="STRING" id="91928.A0A0D2BNZ8"/>
    <dbReference type="GeneID" id="27335109"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08026"/>
    <dbReference type="HOGENOM" id="CLU_035117_6_1_1"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="10">
        <location>
            <begin position="35"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="11">
        <location>
            <begin position="206"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW12839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="336" mass="35407" checksum="32C677AEEF8435FD" modified="2015-04-29" version="1">MSAILVSTAFKRTTSRLSSATRHFSCSASRDASWGFIGLGAMGYPMAKNLRAKMPQGDTLTVFDVNQASLDRFTQEAVPAGVTIAKSPREVVENADTIVSALPEPRHVKGVFEEVLASALPAAPTQSSRLFVDCSTIDPTTSRAVAKLVQDKAGAKFVDAPMSGGVVGASAGTLTFMVGAEKEDMPKVTEVLLLMGRKVWHMGPQGTGLSGKLANNYALAINNIACAEAMNLGLKWGIEGKALADLLNSATGRSWPSEINNPVPGVIETAPASKDYAGGFGVSLMNKDLRLAISAASEAGAKLVLAQTAKEVYDETEKAHKGKDFSVVYRWLGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPW6</accession>
    <name>A0A0D2BPW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Box C/D snoRNA protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Zinc finger HIT domain-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_08351</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233380.1">
        <property type="nucleotide sequence ID" value="XM_016382677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPW6"/>
    <dbReference type="STRING" id="91928.A0A0D2BPW6"/>
    <dbReference type="GeneID" id="27335434"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08351"/>
    <dbReference type="HOGENOM" id="CLU_025524_5_1_1"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000001">
        <property type="entry name" value="box C/D snoRNA protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="15">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="189"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW13164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="458" mass="50263" checksum="A9AA0253FCC5A900" modified="2015-04-29" version="1">MQADGSNAVLTDLCAICHTNPIKYTCPRCGIHTCSLPCVKRHKAWAQCSGIRNPAAYRKRAELATPSSIDQDFNFITSVERSLQRADETAHDKGIDLAPSGVGRNGPDIKRKFDAEVEERGIRLIRAPAGLSRNKQNKSHWAGGQNKCILWTTEWLFHDGQKKINNVRETRTVAQAFLEVFGRRTLGRKRKRDVAETNGAPASQCETAATQQNLEAEDSAKVEPEDTTTTITPGLPGAMGDLGHYESADDDGTIYGDEEHPANASGSLEVNMPQSQVILTEPGNDPSRAQGHPALKESLDTKAILTDNTGCQPATVEKLSPAGGDSLTQNCYLELPSTSTGPNDNISQLLSHLHFYLLRPNTAKFKCLIPIAQTSTLKDVLRDRTLLEFPTFYVREEPPESLPEPFISEEKYTQLYGSQMDVSLPAYSAPGNDDSHPQPLTDIDEQKVLEVLQQDLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQX6</accession>
    <name>A0A0D2BQX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233785.1">
        <property type="nucleotide sequence ID" value="XM_016383082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQX6"/>
    <dbReference type="STRING" id="91928.A0A0D2BQX6"/>
    <dbReference type="GeneID" id="27335840"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08757"/>
    <dbReference type="HOGENOM" id="CLU_007383_12_0_1"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="154"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="350" mass="38719" checksum="5B9312DCBEBD14F1" modified="2015-04-29" version="1">MSTTTKILLTGATGYIGGEILANLLKSKYDSLKASAITCVVRGDKAEALKDLGVKIIQFNTLDETEILADAAAEHDGKYNAPIDRMDRLLIEINSRLAKRKKNTGRDVHYIHTSGTSNVADRPVTKQYLESGYPLSDKEDIFSYLKKRDEDVPYAQRTSDVVVTEVGLEYGVKTYIMMMPCIYGIGAHPLHEFCHVPILIRSGLKLGKVPVVGDGSAIWDHVHVEDMASCYELILHRILTQQDVPSGKDGIYFVENGEHTWQEIGQRVADAGVAIGALETNELRSLDLAEAKDILGRGWGLIAEIGWASNSRTRGHKARALGWTPQKGEDVWKSHFTADWEAILKSNSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRM9</accession>
    <name>A0A0D2BRM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein END3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein end3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Endocytosis protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PV08_06675</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234110.1">
        <property type="nucleotide sequence ID" value="XM_016381008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRM9"/>
    <dbReference type="STRING" id="91928.A0A0D2BRM9"/>
    <dbReference type="GeneID" id="27333758"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06675"/>
    <dbReference type="HOGENOM" id="CLU_040829_0_0_1"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000339">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="23">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="23">
        <location>
            <begin position="144"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="368"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KIW13894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="410" mass="46889" checksum="66DEA0C2A05ED888" modified="2015-04-29" version="1">MSTKRIEKWEIDRYWEIFSSLVTPPATPSSHLTNAAAAAVLRNSHLRDDQLERVWDLADVDGDGELDFEEFCVAMRLIFDLVNGEYQDVPKSLPDWLVPESKAHLVAANRALSGAPSAQFERIEDDEDDAGLKDGFDWYMTPGDKRKYEEIYSANKNRRGEISFESLHSLYSSLDVPDTDVRSAWNLVNTSGRDTISKDACLAFLHILNFRHEGYRIPRTVPPSLRASFEGNKIDYQIDSMRNRPNKYDEDTSTGRKAKFGDAYLSRIGGRGGSAYQPKGTDFSDVVEDEDLEKVRLLRELRELESQHDAAIAASARRRKQREENGSRQPGKTNWTLVKREAQQLLEYKQRQYVDLNSDKANQSGNDLKRLRDDLALVAEQIAGLESHLRKRESELDSIRREIENEKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSZ0</accession>
    <name>A0A0D2BSZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241726.1">
        <property type="nucleotide sequence ID" value="XM_016376450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSZ0"/>
    <dbReference type="STRING" id="91928.A0A0D2BSZ0"/>
    <dbReference type="GeneID" id="27329173"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02090"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_11_1"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="209"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33418" checksum="E57733C6611D3623" modified="2015-04-29" version="1">MAKFNERLVWERFLSTSLSPVTVFMAVPTIWVKMIGYFDQHFKNEPAKAARAEDSAARLRLAISGSAALPAPVRNAWAQIANGYLLLERYGTTETGITYSERLTPNGRVLGSVGWPLPGVQTRLVTAEGQDVTKVPDVTGEIQIKSDGLMKEYWGRPGAAEQSMTADGWWRTGDLALVKAEHGNATFIQGRASVDIIKSGGYKISGLDIETAMLQLPYVQEVAVVGVPDHAWGEAVAAICVPVEGRHADLTIANIREDLRSQLAAYKLPQRLCVIKEMPRNAMGKVQKKALREQCFPRSREAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BTC9</accession>
    <name>A0A0D2BTC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_02250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241886.1">
        <property type="nucleotide sequence ID" value="XM_016376610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BTC9"/>
    <dbReference type="STRING" id="91928.A0A0D2BTC9"/>
    <dbReference type="GeneID" id="27329333"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02250"/>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="116"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="608"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW21670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="631" mass="70093" checksum="F30EA50C8B4C14FE" modified="2015-04-29" version="1">MAEKHSSEKVEYASHDEARQTSPTGLMPIEILRENSTARLVNPLAGIAKDDLMLQVERFATDKGLLDILPLLQKGAYVAQAAIPLAEIEELDPDELEGLQHEIKHRWTHPFALYATVFVCSIGAAVQGWDQTGSNGANLTFPVEFGIGSGSSRDNWLIGLVNAAPYISSAFLGCWLSDPFNSLLGRRRATFVAAIFCILTPIGGALSQSWHQLLVTRLLMGFGMGLKAATIPMYAAENSPAIIRGALVMGWQMWTAFGIFLGFAANLAVYKVGKIAWRLQIGSAFIPAVPLALFIYFCPESPRWLMKKNRYRKAFESLCRLRKHRIQAARDLYYVHAQLLIEREMAAASTYIVRLRELVTVPRNRRSFIAALVVFMGQQFCGMNIIAFYSSTVFVEAGASEHTALLTSLGYGIVNFVFAIPAIFLIDRCGRRSLLLSTFPHMAWTMLAAGFCFYIPESSKAHVGMIALFVYAFTALYSVGQGPVAFVYSAEAFPLSHREIGNSWAVSATFALSSALSLTFPLMLSKFTPPPGAFGFYAGMNSFVLILIFLFVPDTSGYTLEELDYVFAVPTRQFVNYQVKKVLPWALRRYLFFRRGEDLEPLCRFERSDQQGSQGQMERRVETDSKISGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BUP3</accession>
    <name>A0A0D2BUP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhnB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235165.1">
        <property type="nucleotide sequence ID" value="XM_016382063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BUP3"/>
    <dbReference type="STRING" id="91928.A0A0D2BUP3"/>
    <dbReference type="GeneID" id="27334819"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07736"/>
    <dbReference type="HOGENOM" id="CLU_046006_22_1_1"/>
    <dbReference type="OrthoDB" id="10255422at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33990:SF2">
        <property type="entry name" value="PHNB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33990">
        <property type="entry name" value="PROTEIN YJDN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhnB-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="177" mass="19726" checksum="E1AF20582058058D" modified="2015-04-29" version="1">MSAPSKDSKIVNCLFFASQAEEAAKFYTSIFPNSSIDEIVHFPEASTKMHGQPAGSVMLVVFSLNGQCFTALNSRPAEVNFTEAVSFQVTCDDQEEVDHYWDKLSEGGDETVQMCGWLKDKYGVSWQVVPKDLMKLMLGATPENRWKAMQAFGKMRKIVLRDVLDAVEGKNEKAAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BV68</accession>
    <name>A0A0D2BV68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235360.1">
        <property type="nucleotide sequence ID" value="XM_016379533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BV68"/>
    <dbReference type="STRING" id="91928.A0A0D2BV68"/>
    <dbReference type="GeneID" id="27332272"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05189"/>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="274" mass="32131" checksum="4E8614C51933EBDD" modified="2015-04-29" version="1">MRLLEALTNGEFRLTETFPDNEISLYAILSHRWESDDQEVTYEDMIKGQGRDKAGYDKIKFCGEQATRDGLQYFWVDSCCIDKSNGGEYQKAIRSIFHWYRRASRCYVYLSDVFVSPYDSNDIQRWESDFRNSKWFTRGWTLQELLAPRSVEFFSRNGVRLGDKGSLQQQIQQKTGIDIQALQGARLTQFSIEERFAWMERWKTTLEEDKAYSLLGIFDVSISIHYGEGMANAFRRLEDEINKQTRCIQDLLSSIWPRLPLRANDGANIRIGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXE1</accession>
    <name>A0A0D2BXE1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Negative regulator of the PHO system</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_05999</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with a number of cyclins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236165.1">
        <property type="nucleotide sequence ID" value="XM_016380338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BXE1"/>
    <dbReference type="STRING" id="91928.A0A0D2BXE1"/>
    <dbReference type="GeneID" id="27333082"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05999"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000410">
        <property type="entry name" value="Probable PHO85-cyclin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="9"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW15949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="338" mass="38101" checksum="8F4DBD12DC0808C9" modified="2015-04-29" version="1">MDRRHPSSFQQLEKLGEGTYATVYKGRNRQTGELVALKEIHLDSEEGTPSTAIREISLMKELKHENIVTLYDVIHTENKLMLVFEYMDKDLKKYMDARPENRGQLDPPTIKGFMRDLLRGTAFCHENRVLHRDLKPQNLLINTKGQLKLADFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSAGCIMAEMYTGRPLFPGTTNEDQLQKIFRLMGTPSERTWPGISQLPEYKSNFPSFATQSLGILLPQIDPLGLDLLSKLLQLRPENRISAQDALRHPWFQDLPDFAGQGRTHASATMRQPSQLAHQGGGIGGYGTQPGMVAQGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0U9</accession>
    <name>A0A0D2C0U9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237525.1">
        <property type="nucleotide sequence ID" value="XM_016378848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0U9"/>
    <dbReference type="STRING" id="91928.A0A0D2C0U9"/>
    <dbReference type="GeneID" id="27331584"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04501"/>
    <dbReference type="HOGENOM" id="CLU_003477_0_0_1"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="875" mass="99576" checksum="676BCEDA6D7F57E6" modified="2015-04-29" version="1">MLPLPVRQHAGAKYRNHRRIHAIALAGTPVLSDVASPFHSPVRSRWVGRASIGRSRHQSRSLTVSRPWLEAHKPAPKTRATHDAVVLSSSALLRAAKYRTLATLLQKRGRTLVPQGASISDVSFEDVLNVVEAEESIGSNHSKVAKRLREVFPGRSLEEVMGELELLEDGQLRKSSAGQKLAFDERTKNTLINLGLVDEGRNDRTQQPADHDSTAVPAPSKKPLSVRAPTAQPTIRRLAGAGRVRPFLSSRTSSKVSDSKSEPRQETELFENQQEIDLEGFDFKPLDVERSQVPQLSHDLSRVLFNPGVYQLQDPRSRVWNFDPYLGKLMPVSEFNYDALNQYITSSQDQTLRDVALQHDKRYIGSTSSMSGVLAHFHFLLSRWRELTLDHLSRGFRDDGYQFTKIQRGPSAIFLKYKDGVYAVDADKEYDSANILMSLGRSMEKLLTNDKDVFETYRKTRGEDEANQAQPSEPEAYHYSELGSFLIRSQLDAYDPRLPGTGMFDLKTRAVAAVRMMVRKHEQGVGYQIKQRFGTWESYEREYYDMMRSAFLKYSLQVRMGRMDGIFVAYHNTERLFGFQYIPLSEMDLALHGQTDATLGDREFRHSIKLLTEIFNAATERFPEQSLRFHFETREATQAHAPYMYIFAEPVTDEEIVDIQNSNREEIEAFEQRIFNPEKFQKERNTKEEDLEAEDNDLETAVDNTSQATSAEAVTPGTPNRQSNAADVDFLESLMGVDLPAVKTPVPEKPAPSSKVDVTADKPLLGWKLNITNLVNKLPVDRPQDLKPSDSWSVRYSLTPMKDASSRRNYVLCKNRRKSVLQAPQDEDTSVQYYIQRLVSMSKEGAKWRRKLDEFDAQREKIVLYGDRISGEKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C2E6</accession>
    <name>A0A0D2C2E6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238035.1">
        <property type="nucleotide sequence ID" value="XM_016379358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C2E6"/>
    <dbReference type="STRING" id="91928.A0A0D2C2E6"/>
    <dbReference type="GeneID" id="27332097"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05014"/>
    <dbReference type="HOGENOM" id="CLU_771601_0_0_1"/>
    <dbReference type="OrthoDB" id="4121110at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="364" mass="44040" checksum="9D6BF6C9C80A3AAD" modified="2015-04-29" version="1">MSHNDDYAPRSRRDHSRYDQDPGTRYPDDDYPDTRKSGTHRPRYEQSPPPYASDATRRREDIDPRDIEPRDADKKKHRDYPSERDGDMKKAPKSNTAEPRRHSPRNDDDDGDSATRRHRDPDAGYGRSRGYRAPLPRHESHANDGDDLKARSAKPRRRDDYDDFDPAPPRRAQTYREPDRKRRDDAYDEPPRRRYRSPDDRDRHSDPDRSSARHRRDDDRYDDRRYRSGAGGHSRRDDGYASDRDHKRSDRDKGKDRYYRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRRHYDSRDRSRDRDGRSKKKGFSFDDIGGLVEQGQKHYKTVAPLVTSIAKMYLDNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C360</accession>
    <name>A0A0D2C360_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Haloacid dehalogenase, type II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238225.1">
        <property type="nucleotide sequence ID" value="XM_016376655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C360"/>
    <dbReference type="STRING" id="91928.A0A0D2C360"/>
    <dbReference type="GeneID" id="27329379"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02296"/>
    <dbReference type="HOGENOM" id="CLU_045011_2_0_1"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27890" checksum="A809C495A5144E9A" modified="2015-04-29" version="1">MPTQQKHVVFDVVGTCVSFDAYYNTIDSVIGDKLRRHTITAKHFGFTWQTVAELEFTFLSISERYRPYKEVMRAMFYRSLWLAGVSDPQSFATDEQREKCIEGYSALELRPGCRECFQVLRDAGFTVWCFTTGDAKRVRGYFERAGVEMPLENFVTCDTGGVAKPALAAYRSVLNQLGSESERWFAAAHMWDVSAAVKAGFTGAYCTVYELDPCMDIFEDEMQVVEDSLPDMAKAIVAASARGIACLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C5D9</accession>
    <name>A0A0D2C5D9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Het-C-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239025.1">
        <property type="nucleotide sequence ID" value="XM_016377455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C5D9"/>
    <dbReference type="STRING" id="91928.A0A0D2C5D9"/>
    <dbReference type="GeneID" id="27330181"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03098"/>
    <dbReference type="HOGENOM" id="CLU_010063_1_0_1"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF11">
        <property type="entry name" value="TINC (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239461" description="Het-C-domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="979" mass="108491" checksum="DFCB74D03D4C817C" modified="2015-04-29" version="1">MALSSSHIVLLCAIGVVLLARPAHAFGAGNIGSTSKIEGQNWRHGDLEDTLLTIVAARAMGGKKFGKLDVKRVYFGNWLRDYSQAVDVGTVKYVSAEAIRILLWVLGFMSFGYGSGEFEVTTQRLGCYRPEEHIDNPKDYADNEDARQYDRRLRGPVDERRELAINPETGLKNYIASEGMGIDTSAGLVRHLFGRSIELGRQYARTKNKKDLYEALRLLGTGSHCLEDYAAHSNYVELALIELGERDVFPHVGRRTQIELREARHPVYPVVTGTFGGVDFLHSVCGEFDDKTTQSEIEELEGTMQQYQGMNNDDSVLQDLLNKVPSGIFGGKDEAGKANELKQNAVNHQMQNARISPREPEEWTQYLADVQKQIYPIIEWHDEIMQSITETIEKIPILPDLIENIQDEINKFVFSLLAPYVVPIINQVKNELNTGSNEIIQSSLDKQHIVFNDDCSSDPTHSMLSKDHFSNILNEPAGKVARQTIQWVVPQIVAAWDDDRIDVDRTLTRIINGVLHHPALRDYGQDGAGDGRRLMFRVVEEWWQGKDEREKDDFREKLSREGVESGKNHKEGVHDHGHGSNRPLGMANLNYNNGGSSGLAGGALGALGSAMGNASDSRPSNEAADTFGKMAGEAVGGGVLGSLVGGLASNIGGGILGGGLNKGEETYQSESYGQDGSYTQTTTQVGHSQSGDRYGQAQYSRTTAPHGQREEYSRFEQRQSGNHWQSEVRHEEHTSDGGYREETRRYDNDGDRPSHGRHHGQEQSYGRRHDDDGEERFSSGYGSSGRDTYGQQERRQEYGRRDDDDTGYGSRRDNESSEYSSRRNDDEYGSTTSYGRQERQSEYSSSGYGRQEETSYGSGGYGSRREESDDMPGGFGGRREEQSYGSSGYGRQTEYGKSGGYGGGRREDNYGSSDVPGGFGQQSESGYGGGREFESEGRGYGGNSGEYGGEGYRRQRRYGENEDEGEGEGGYGGYGSSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6A4</accession>
    <name>A0A0D2C6A4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239290.1">
        <property type="nucleotide sequence ID" value="XM_016377720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6A4"/>
    <dbReference type="GeneID" id="27330447"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03364"/>
    <dbReference type="HOGENOM" id="CLU_028818_2_1_1"/>
    <dbReference type="OrthoDB" id="5086080at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF7">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="64489" checksum="16FEDD64675D2C89" modified="2015-04-29" version="1">MTTKTATTAIAQRSATNDSAESSEKGVSSRRLKKREIDRRCQRQARERTKSRIAHLEGLVEEFRRQDATGQVALLMKQLQEAEAERNLMAKTLKDIQKALDLRRPPASHEEPVFLDEDDKQKPSIESLSDDTPLNFKTESEEDVQVSVVSSFDRTNFTPSPNTNDKPPGTLLAPPIVQLSCDNPGPKNQALVQCKSSENDGQQLPLWTDHWARPRKSCTCHTFSKPVPGQPVVWRGNYWVYANQVLSQRFGWPKDITPASAEVSDDVPVRALLEGWDSVAKRGPLHPSWQILRQIDENLFCTCPDTERLAVMRAMHALIQFHTESTSQLFQRLPPWYMRRPSQSIAHSYAIDYYAWPGLRERFIFGEHNYCQNEFWRLFCKSLRILWPYEFRDCYTREVETGLYKINPMFDQRLGDIKCWTMGPDIFQRYPELYSDMPTFNQIPQQVPTRASRQENNTITHPRSRRAATSSTDEQDKAIKLPSAPTHYVPMQHNYAHVQQPNGSGYIQSGVNSNHSNPNPHAYNLSDITPIMALDAFAFGAISEVDFAAVFHPEASEGYPTVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CB46</accession>
    <name>A0A0D2CB46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA damage-responsive protein 48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241005.1">
        <property type="nucleotide sequence ID" value="XM_016375729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CB46"/>
    <dbReference type="STRING" id="91928.A0A0D2CB46"/>
    <dbReference type="GeneID" id="27328450"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01367"/>
    <dbReference type="HOGENOM" id="CLU_100306_0_0_1"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12052" checksum="0683E4C21AF5EDF2" modified="2015-04-29" version="1">MDQLKGALNSFTGGDNQQQGQGQGQQGQNQGDGGFLGGLGDKLNSAAGGGRESEKNEDALDKGIDFVQERFLGQGPQDNESAIEQAKDEQISDFIRNQYKSATGNDFPVKDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CBM7</accession>
    <name>A0A0D2CBM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methylenetetrahydrofolate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="12">1.5.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_01498</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.15" evidence="12"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241135.1">
        <property type="nucleotide sequence ID" value="XM_016375859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CBM7"/>
    <dbReference type="STRING" id="91928.A0A0D2CBM7"/>
    <dbReference type="GeneID" id="27328581"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01498"/>
    <dbReference type="HOGENOM" id="CLU_031413_0_0_1"/>
    <dbReference type="OrthoDB" id="41403at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01079">
        <property type="entry name" value="NAD_bind_m-THF_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000255">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000012">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035812">
        <property type="entry name" value="m-THF_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="15">
        <location>
            <begin position="14"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="16">
        <location>
            <begin position="147"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW20919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="335" mass="36861" checksum="6D5B8555E997BA05" modified="2015-04-29" version="1">MSKDETTSCKTILAGTIAKGLLSEVQAGLSKLGRKPHLLGILANADPAAKVYADWTEKTCNDNGFAYTLKSVAKDDVEETIMAANNDDAVDGIIVYYPIFNNRQDQYLQQIVDVSKDVEGLSHQYIFNMYQNIRFLDESQAIKSVLPCTPLAVIKILEFLHIYNTILPYGNRLFGRTICVVNRSEVVGRPLAALLANDGASVYSVDVTGVQLFTRGEGIRKRKHEVHEKEGWTLETCAPLCDVVITGVPGDKFKFPCHLLKEGAVCINFSSEKNFPVEVKQKASIYVPAIGKVTIVVLLRNLLRIVQNKQARLAQSHTTTVDGTQTEGGVDKATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCN7</accession>
    <name>A0A0D2CCN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_01844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241480.1">
        <property type="nucleotide sequence ID" value="XM_016376204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCN7"/>
    <dbReference type="STRING" id="91928.A0A0D2CCN7"/>
    <dbReference type="GeneID" id="27328927"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01844"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW21264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="61688" checksum="4C716BF7FBE2802D" modified="2015-04-29" version="1">MERMTLFSPHIILGLVVVVGYLAYLAFTTGRRPKDFPPGPPTIPILGNIHQMPTRDAPLQFEKWAREYGPVYSLMLGTKTMIVLSSDEAVKELLDRRSGFYSDRQEMYIGQKLCSGDNRMLMMGYGPRWRGFRKMCHALLNIQAAKSYVPYQTLENKQMLYEFLHKPNDFIKHIRRYSNALTTTMVYGWRTPTYEDPKMMQLFEGFSKFAAINQTGASALFEFFPILRRIPDFLSPTKRLAKELHRHERELYLGHWLNAKAAVKNGTIPPCFCVGMAEAQKADGFSDDQAAYIGGTLLEAGSDTTSSTLVGFVLAMLLYPETQKKAQAEIDQLVGDRLPTMEDEPHLQYVRGVIKESLRWAPTTPLGGVPHAVTKDDEYMGYRIPKGAGVVNNAWAIHMDPKRHPDPRKFDPMRYAEDTQSLSDSATNPDGTKRDQFTFGAGRRICQGIHVAERSLFLAVSRILWAFNIEPAKDDAGDPIIPDQEKFTQGFVCMPEPFPASIKPRSQAKAKLVDKEWFDAEREFLDPDTKQWLKTPPGVLGSDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CDQ2</accession>
    <name>A0A0D2CDQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241890.1">
        <property type="nucleotide sequence ID" value="XM_016376614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CDQ2"/>
    <dbReference type="GeneID" id="27329337"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02254"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW21674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="531" mass="57987" checksum="275C33EB7CA786BD" modified="2015-04-29" version="1">MAQIPGLQSRGGESKKFIGTGKSLTVWISVATSTVLVFYGYDQGVFGNVIVSHDFLKMASLYTLGSLFGAVSTIWTGDILGRPNTILAGSGIITIGAILQASAYGVPQMIVGRIIVGLGTGMNTATAGVWQSETSKPQSRGKLVMIHMAQCISGFSLSNWLTLGISFAPGSVAWRFPLAFQIVFAVILCCICPWLPDSPRLLIRKGQKDEALEVLAALEGEGATRYSDSVQLQYDIIKDVLDREHVNTYSWWTLLRGRGPAGVLRRMALGAGMQAMNQISGINATSYYTTYIFINALGFSEVRARILAAAGSVNYLIFALLSYLPIERYGRRRVFMTSSAVCSACFVAITIALYLSDSGKKSSFNMGVVAVAFFFVFWSAFGAGALGVPWLYASEINALEMRAKGASVAMSTNWIVNYAVVQVTTDGINNLHWRFWIIWAVLCASFVPITYLFYPETANRSLEDIDRFFETEPKAVICNNQLATQLKRPSEFEEADRVVQRHMAREGGACVEKSQVEQVDEVANAHLEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7G4</accession>
    <name>A0A0D1Y7G4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231067.1">
        <property type="nucleotide sequence ID" value="XM_016384465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7G4"/>
    <dbReference type="GeneID" id="27337233"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10150"/>
    <dbReference type="HOGENOM" id="CLU_1090023_0_0_1"/>
    <dbReference type="OrthoDB" id="10620880at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002236887" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30522" checksum="1C7E2655795D5383" modified="2015-04-29" version="1">MYFYSSPRRPQWTMLTFTLAVGTLLGAAAGAAVSVPPDAQSVRHCSRLCLNQERCEFIFRGRGRSAASALCGAIPERCADVPGCEQFLVQGVSPQREEQDQQDQRRQHYPSKIVKDAKSVRVPSHQEADDDAREEEDEEEEASKETTRDWSQTQPGQSCASICDAYWFCVRRDPWAEEICGSIPRQCKHEPECRGMQVNDSRGGDSKSTAKDYYTSREEMEDNVRNSHGHETPDRKNMRRPGWITAQLGNKYGGQEDEEEGIHDLEVSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7Z8</accession>
    <name>A0A0D1Y7Z8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231262.1">
        <property type="nucleotide sequence ID" value="XM_016384660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7Z8"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7Z8"/>
    <dbReference type="GeneID" id="27337428"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10345"/>
    <dbReference type="HOGENOM" id="CLU_006937_8_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="63218" checksum="4D9D901059862F3A" modified="2015-04-29" version="1">MPQIKTELREYGRRRAQTGPYADNLEVDALVVGGGFGGVFCFYELRKAGFNTVIYEAGNDLGGTWRWNCYPGAMVDSEIPEYQLSIPETYKDWTWPSNYPTYEDLRAYFDHCDKVLDIKSHTAFDSVVVDAQFQTGEGRWHVKTADGRTAKAKYLVVAAGFAAKRYIPDEFIGIDKFQGICHHSSFWPDLNIDVSNKKCCVIGTGASGVQITQKWGPIAGHLKVFQRTPNLAVPMRKRALTAQEQNDQKSMYPELFSLREKCFGGFLYTFSEKGTFEDTPAEREAFYRKLWTDGGFRFWLGNYKDYLFDPKANREAYNFWAKNVRYRVGDPRTRDLVAPLDPPHPFGVKRPCLELNYYEQFNRENVELVDIKNNPISQFTEKGIRLKDGTEHEFDVICIATGFDIVTGGMTAMGLRNINGNLLQDEWKKAAYTYLGTTISGYPNMFHLYGPQGPTLLSNGPTTVEVQGRWIVDAIKQVERQGLKYINPKAEAQAEYKKKINALSDISLFPTTKSTYMGGSKPDKAFEQTNWAGGIPAYHAEIRATLPDFVGFEKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y806</accession>
    <name>A0A0D1Y806_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231277.1">
        <property type="nucleotide sequence ID" value="XM_016384675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y806"/>
    <dbReference type="STRING" id="91928.A0A0D1Y806"/>
    <dbReference type="GeneID" id="27337443"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10360"/>
    <dbReference type="HOGENOM" id="CLU_017272_0_0_1"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="186"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="849" mass="95250" checksum="326E00FDE0E65098" modified="2015-04-29" version="1">MEHEVAYDFKDEGHFWTVLDETISRECDSHGTIDDTLRSYLTLIGAFRERLHASDYELSRCAYKLQESDLFTNHADYIRRQFVQCLIEDDEPHVLLLSTLFLIADAQSHERTYELLSEEGAFPRLVDLMASPKRHGHEEIHRSLMELLYEMSRIQRIKTSDLAHIDDDFIKMLFEIIEQVSDDVNDPYHYPTIRVLLVLNEQFMVAAHDPAGSQTGVPLTNKVIKVLSAHGSAYKTFGENIILLLNREDETSLQLLTLKLLYLLFTTPPTYEYFYTNDLRVLVDILIRNLLDLPEEASSLRHTYLRVLYPLLEHTQLQFPPYYKREEIRKMLQVLGGGQLREHGPGQDDQHHWGHFEAVDETTKRLVKRCEGVSWLTDPETEPPVQAESPTSDVASDLSSPASPIKGHPPALPAPRKLKKRNSSKASTLTIGHYLTPHLESARQSSLSMIEVAAQREKPGVMTPSRNPTLKNNLRAAIMHKKDKPPPPPQARRSGSSRPKLTENSTEIEVMKASSTEEAPVSKPEVPNHHHHHHHHHIPHPPLPHLRHHPTPPVPGVEQGNEKEKILKSPVPPPIPSHHKGHFSPKKPPPAPKSRRWRKTYDHSNATREPGKFNASLPSIVTTSTAGNEVIEQSPFSPSLPHEEKTLSPTSLDSAIGKEKMGVKEALELARAQAVDDVTGTLEQVELKDESKDQVEDNPNPAELPEAEAGSGKAEESDRRQASGDTLDPEMSRTRSDDDLDLPFHDAKQSLPQSPLRVSPSPSPGPQNLDSTFLSVSATNALPHQRAVLTPPGQEPSRGVPGPQYALERSPFLTDEEEEEEEEEDAGEVADGSDDEGTVDENTHHDGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y9J2</accession>
    <name>A0A0D1Y9J2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_10958</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231872.1">
        <property type="nucleotide sequence ID" value="XM_016385270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y9J2"/>
    <dbReference type="STRING" id="91928.A0A0D1Y9J2"/>
    <dbReference type="GeneID" id="27338041"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10958"/>
    <dbReference type="HOGENOM" id="CLU_003291_4_2_1"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW11656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="544" mass="58284" checksum="3EFEBE031FFBC927" modified="2015-04-29" version="1">MAQEWKLKDLTTLDLKDLDKVEVEVEGIEGGKVLLVKVGDQISALNANCTHYGAPLKNGVLTPEGRLTCPWHGACFNTKTGDVEDSPAPLALNKFNVVEKDGGVYISGKETDIKGGKRPVNVKTTPSTPERVVIVGGGSGTFGTILKLREHGFQGHVTVITGEGLPIDRTKLSKALITDASQIYLQPEQWYKDGSIEFYPDTVTSVDFDSREVKTKTGKAFPYTKLILATGGTPRTLPLPGFKELSNIFLLRQVSDTQAIMNAVGDGNKKIVIIGSSFIGMEVANALAKNNSVSIVGMESAPMERVMGAEVGKIFQRMLEKNGGKFYLNAGVDSAVPASNLANAVGLSSVRAVKLKDGAELEADLVILGIGVKPATEYLENNASIKLEKDGSVAVDQNFAVKGLSDVYAIGDIATYPYNGPGASDTPVRIEHWNVAQNMGRTVGQLIARPGSKPKPFIPIFWSALGSQLRYCGSTSNGWDDVVIKGEPENGKFAAYYCKGDAVVAVASMMMDPVMVKSAELMRHNKMPSKKEIQGGEDVLQASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YB82</accession>
    <name>A0A0D1YB82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="19">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PV08_09462</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="19"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232402.1">
        <property type="nucleotide sequence ID" value="XM_016383779.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1YB82"/>
    <dbReference type="GeneID" id="27336545"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09462"/>
    <dbReference type="HOGENOM" id="CLU_000556_0_1_1"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000015">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="21">
        <location>
            <begin position="1516"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KIW12186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="2235" mass="254900" checksum="6BC2976520C5702C" modified="2015-04-29" version="1">MPVRKPNRYGSNVRFSKPSSRPQRTKTIDAASLRDTEATSQDEKFQAIRLANSIDESMGFLRYDSGKRRVGWLYNMHSTVIEDPKVSGGRAGVDFYFIGEDDENFKATVEYDPYFLVAVKRGREAEVEEWCKRMFEGLVKSVARVTKEDLNMPNHLLGYKRTFLRLNFANVNDLLAVRKSVLPIAEKNKEKVNAMDTYAEVASATAGFDVYDEEQLNETTANGIAEASDFIVDIREYDVPYHVRVTIDEDIRLGKWYTVEAKHGTVKLTCLEDRLQRADPVVLAFDIETTKLPLKFPDSVIDQIMMISYMIDGQGFLITNREIVSEDIADFDYTPKEEYEGPFMIFNEPNERAVIERFFSHIKEARPNVIATYNGDFFDWPFVEARASVLGIDMYAEIGFRKNSEDIYQSDYCAHLDCFAWVNRDSYLPQGSRGLKAVTVAKLGYDPDELDPELMTPYASEHPQILAEYSVSDAVATYYLYMKYVHPFIFSLCTILPLNPDDTLRKGTGTLCEMLLMVQAYQKNIVLPNKHKEPREAFWEGHLLESETYVGGHVESIEAGVFRADIPVNFAIEPAAIDELLRDLDAALKFCITVEEKKNLDDVTNYDEVRAQIADKLNSLKTTPLRNERPLIYHLDVASMYPNIMTTNRLQPDSMISESDCAACDFNRPGKTCDRRLPWAWRGEFLPTKRDEYNMIRRAMVNETFPGKHPKSMRRTFQELSLDEQAAAVRKRLQEYSKKIYHKIHDSKTIEREAIICQRENPFYVDTVRDFRDRRYDFKGKQKVWKGKTEALKSSGASATEIEEAKKMIVLFDSLQLAHKVILNSFYGYVMRKGSRWYSLEMAGVTCLTGAHIIQMARELVERIGRPLELDTDGIWCMLPATFPENVVFTLKNGKKMAVSYPCVMLNHLVHASYTNHQYQTLIDPTTFKYETHSDNSIFFEVDGPYKAMILPTSKEEDKNLKKRYAVFNHDGSLAELKGFEVKRRGELKLIKIFQTQIFKFFLEGTTLAETYAAVARVANRWLDVLHQHGDTLADEELIDLICENKSMTKTLEEYGAQKSTSITTAKRLAEFLGEQMIKDKGLNCKYIISARPRNTPVTERAIPVAIFSADENVKRFFLRKWLKEDPGDMDPRTVIDWDYYLERLGSVIQKLITIPAALQKIRNPVPRVAHPEWLQKRITAKDDKFKQKKMSDLFEKKPLAERSVNLLDHRLPPTGDIEDALDAGFKTPVQLTKQSKRKSPDNINQAVIDPYADLPTDAPTADEDYSGWLQHQKQKWKIQKQARDRRRQLFGEKPNSATDSISSFFRNQAEMLFINTWQILQLRQGESPGEVKTFVLIGNKIHPLAIKVHRTLYLNLKGEELPNVEIPGCEVEKVNHALPNGHPSVHLFQLSMSEDTYLREAESVSLLCNHPSVEGVYERQLPLFMRAMLKLGNMCSFDESQKGVLGKGLEQGFDLSSLLRSNSHSTYLENLGAFGYVYFYHITSGERSVFALFSTSRSEAHIIILSRTRDAQLPNATKIYAEQYRQKTAEEALVDSVFEYQPSLHFKMSQVTTRRKAHLEIGEILKKWRSEESKPTMILMQSTSSTQLAHDVRIVRDYPILSLPAEHADADLPPLGWQAHAFKQLISHYLNAAGWLAHLTELARYGDVPLCNLEKDDPRFLIDLAYARRLKRSNVVLWWSEQPRPDHAGHERDDILGPLTEVVEMPSINNPGAYTSVCVDVSVQNLAINTLLTSSIINDLEGSADSVAFNPAADDEPSGSGIARSNGGFAQAALEVLRDMVKSWWTEACQGNRLADVMVQHLVRWVEAPASCLYDRHLHYYVQMMSKKAMQQLITDFRRVGSHVVFASPTRLLLQTSKQEVENAYAYSQYILKSIKQKPLFHFLGLEVKDYWDVLVWYDAYNYGGKGTSAITEQTTPSNLETVVHWQLSQFLPVSLQPVFEDWVITFIEVMQNLKRPPIESGGSSSTPRATQLPSAFISLTEDPTSTEVTTVLQDDFSKPLKKQVTALIRRQREELLHPELASDWSFPNLPGGTLESTDARHPRDPVLELVKSLMQIVSLSKPLQLEARLLRKELLTLFDVREFGQEARFENPSASLRFDNLVCDTCTMTRDLDLCRDEDVLPDEQDGANRPWTCLACHSEFSKIALEETLIARVQASLLSWQVQDLKCKKCGVLQGDDAVFSDHCACGGEWVGVMDRREIRNKVNVLERVSSAYGLRMLAGVVEGVKGMCLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YBM0</accession>
    <name>A0A0D1YBM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232557.1">
        <property type="nucleotide sequence ID" value="XM_016383934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YBM0"/>
    <dbReference type="GeneID" id="27336701"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09618"/>
    <dbReference type="HOGENOM" id="CLU_093209_0_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="2">
        <location>
            <begin position="22"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="211" mass="23626" checksum="1F8D09B3F117A4C9" modified="2015-04-29" version="1">MTGQRSGMPSQTRLVRSLFHDLSGTWHLSRKLQSGHPSEPSGRCEGKATFTQTQPSPVLDADGKLQLADAELLYHEEGEFEMDLPSVGQNANVPKFPFSRKYIWRLKESDDEVTMSIWFTKPGTNLVDYLFHTVDIVREDDEGDDPKSPVVLEGSGGHLCVDDYYSSFYTFTLSSEGTATSLSSWTMTHEVCGPKKDQVIKTAFTRPLQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCM3</accession>
    <name>A0A0D1YCM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232897.1">
        <property type="nucleotide sequence ID" value="XM_016384274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCM3"/>
    <dbReference type="STRING" id="91928.A0A0D1YCM3"/>
    <dbReference type="GeneID" id="27337042"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09959"/>
    <dbReference type="HOGENOM" id="CLU_035614_3_0_1"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="18"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="388" mass="42869" checksum="88B8E083DB8DF79D" modified="2015-04-29" version="1">MAEVQGTMDPVFQKLRDSFQENLRSGDELGAAINININGKDIVDIWGGYASEDRSRRWTPDTITNVYSSTKTVAAIAVLIAHERGLLSVDDPVADYWPEFAENGKDKILIRHIMAHSSGLSGWESPITIEEVCDVPYSTARLAKQAPWWEPGSGSGYHATTQGHLLGEIIRRATGKPMKQFVAEEVARPLQADFQIGAAEEDWPRIAPVVSPPPPPFDVDSLDQKSIIYKSFFNPRTAASFSQKPLWRHADMSAVNGHGTAKGLNRILRTVTLSGTPYDDAKLLSPTTVEQIFRTQSDSMDRVLGMPLRFGIGFGIGGGLSEKTFDYLPHEKMCFWGGWGGSFAICDLHRGVTFTYIMNKMGAGIMGNDRSIDYARIAWQILRDEGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YFB9</accession>
    <name>A0A0D1YFB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234002.1">
        <property type="nucleotide sequence ID" value="XM_016383299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YFB9"/>
    <dbReference type="STRING" id="91928.A0A0D1YFB9"/>
    <dbReference type="ESTHER" id="9euro-a0a0d1yfb9">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="27336060"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08977"/>
    <dbReference type="HOGENOM" id="CLU_006586_10_5_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112332" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="45"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="575" mass="62884" checksum="7E7B7C1BF79DAE9F" modified="2015-04-29" version="1">MAKSNTHMSATLLLVFLSLGLSQSQSLPKVDLGYQIHQAISYNSEYQYYNFSNIRYAQAPVGDLRFAAPVAPQGRNEAVQNGSVGAICPQAQASWVPMAYQYAAAVLANRSSSFNITQAEEVIAQTPFDELPVGSPRLGELPPRDPREREDCLFLDVMVPRSVFERAANKSANGAPVLIWIFGGGYVTGSKYDFDPRGMLEAATKDDGEGLIYVAMNYRVGAFGWLGGPTLEAAGGTPNAGFFDQRLAMQWVQDHIHLFGGDPNRVTIQGESAGGKCCSVVNHLLAFGGEKKPPFQRAIANSAGIIQSYSNQVVENVTQSFLSLLNVTTIEAARHAPSRDIIMANARQELASAYGLFLYNPVPDGVFMRQLPSLALLSGHFAKNISVFYSYTQNEGLLFVPPSLQKEEDVTPWLRTVYPTIVDAVATHIQTVLYPPVYDGSQPYLNLPQRIALIIREMAVSCNADFLRQAYLTRTYTYRFDVGPSLHGSDQAYVSWDGRAGTNASQSFFAPLARQVQSYFVNFIQTGNPNAQGLPPFPIEGANSSANRLTASGFLTQPDPEKNPRCAWWAKALAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YFJ0</accession>
    <name>A0A0D1YFJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234052.1">
        <property type="nucleotide sequence ID" value="XM_016380950.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1YFJ0"/>
    <dbReference type="GeneID" id="27333699"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06616"/>
    <dbReference type="HOGENOM" id="CLU_003548_0_0_1"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF195">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="565"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="690"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1495"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="589"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="937"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="625"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1828" mass="205656" checksum="91686661DA5F7EA2" modified="2015-04-29" version="1">MELPKPPVPVPEFVDYVNRYPKSQAGVAEAVKPFKAFESKLREVYAQHPDNPAATANYLVPVFDSAPLTIRARDTGQEPSTEQEKYLLPLTDELRRKHESPATVQSLKEFKTNFNVFSESSLVDLDWSNVVVAGSAVVTSLLPVDAPHNESKRALRSYYHEDLAPASDVDIFLYGLNEEQAIDKIKQIEAKIRDSILAETTTIRTKNAITIVSEYPTRHVQIVLRLYKSISEILTGFDVDCSCVAYDGEQVWASPRALAAFMTQINTIDLTRRSPSYENRLSKYSHRGFEVFWPAIDRPRIGPTIFERSFTRVQGLARLLVLEKLPHPNDRDTYLAQRREERGRPPLPRQKRYRHELPGNIKDAQPDDVAEWVEGDEVSNYHTVGIPYGPRYNAKKIEKLLFTKDLLLNAEWNRPKDRETKLHRHPAFFGSVNDVIHDCCGFCPQPTTDADLAAYEEETKVYISGNLTFLKDDPGRQAIGSFNPITDDDWTEMAYVGNTTRLCQAIVDHDLEAVRDWFSSPDVVDVNRRDHTGRTPLHLATLCSTPEIVQCLIEHGARLVSRLYNGMTALHIAAHRGNVQMVKHILKKSATNEEEESQKEEARKEQRRATASGALDKEASKPENESADSFESDEDVDEMEDEDEDEDEDEAFTEESFVKIRGGEEVPDAMAADDKDEPDVFDIDVLAWDSPLSPLHLAILAGHTDVIDLLIDEYGADALLPVKILDSYDRKSARAAILTIVLALELPLQKANETIKTLISHGASPVQADNNHITAIHFAVDHAKASILETLQNADDTAFSNACNFLAVSGWYSSPSIKAPITTAICTRKVEVVQTLLNAGVRPHIDLESFAQAFKRGIKGHVTDDPEQIKTIYQQHVEQPIVLALNMEMIDLVSQLVDMGEDVNTLPTSAHQYLANAHWRGEPKSLLDLVRDRAKSLESSLHPGPEATLEEPKSLGSDERYLSSGQGTYQYWTAYHDLREAKLVEKYQREEYQHQLVSSSIPAENGTQEKHAAIRDTLLKLSKLEQKLISKGAKPFHELHNVEVSDVNLRRNLYAYNPEPRFKNVPYETKISFRVADLTPEKHAKYLMLFEAAWSGDSDTVRSLCLEGSRPLSVAVSDLRSFSPFSIAVLRGHLELATLIVEIATAQYQPDKKSDQYHYTVQAIDDDEDSDYSERESSEDSREVKVLAQLVNDTFTIDDVVALAENVKSKISPETLVKWNCNVDRALAEDADEAKVSEAFGTYRRPTVWMRGNRSAQSWSWFHEAFDSIQNTRRHSLVRYAIFTNDLVLLKFLIKTGTAIAIRKEDEENLKIMNIDQGDFELAVRLGRLEMISEMIRTTGYGLPLQKMFQTSGVKVDEKPQYYQGLTVHGKKRQDWADASRKGGHYRKTESSDLGIPLLVAAFEGNLEATEYFLSDAPLHRYLEFADSFRGDKHIRALAQAKGGLQGSLTAWLGTRSGLALHLAILSVPNKDGSQPTLDYLLKKMPESLELRSANGSTPLHVAFQPNRYYAAKKLIAAGANQATRDENGRNILHSLLDTFDFDKPALLQSVLGMLDRGLVGSLLLERCTGTDPGGLTPISLYLKRINTPTGWEESVKLILSYSQGKDLEKMDGAGDYPLHSLVRRGSLELVKFLVEYSPSLLHWENATGMTPLDVAMAKYLGSLIEHPPNIVNSTSWSVASVPAMDFAAKRGRDQNDDEEGVDNYSDRSTDWQVYRLVESLVAKHPAKRKLVGLHDANEVAKRLAAQQQKKNAEMRRREKLGMNAGSGRGYSYRYQYQNQESTTGPEDEVSLNLVKARRFIPWDEMAWRINEAGEKGIEYEYTRKMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YGJ7</accession>
    <name>A0A0D1YGJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234332.1">
        <property type="nucleotide sequence ID" value="XM_016381230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YGJ7"/>
    <dbReference type="STRING" id="91928.A0A0D1YGJ7"/>
    <dbReference type="GeneID" id="27333980"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06897"/>
    <dbReference type="HOGENOM" id="CLU_027534_0_1_1"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037350-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW14116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="504" mass="55588" checksum="3816E77C874A1FA1" modified="2015-04-29" version="1">MPAPDDIYRRDVDFTALALQYPDFAKRLKFNRQLDFSDPESVRQLTKALLHRDFNLVIDLPEDRLCPPVPNRFNYILFIQRLLDTTSPDFHEGFDPDRQVIGLDIGTGSSAIYPLLACRQRPRWLFLFTEIDGKNQRYALKNTATNNLQTRIKQLDTDASGDQLIPSTEIERFDRIDILMTNPPFYESESSMLESARSKSRPANSSCTGAPVEMITPGGEVAFVARLVDESKRPASRSRIQWSSAMLGKLSSVGCIVDHLRGQGCTNYAVTEFVQGQKTRRWCVAWSWLGLRPSNAVARGVGGGGFGAGGGSGVEKKYLPPPTEMLVDLPGGDLVGAETRMIAEIGKLDVLWKYSPARRVGILMSREGDVWSRKARRKKLLKDRDQEMKDTTCTPGDPDEDDDDYDDDEEPEPALVVRLCLSSSMSSSSSSLSSSSSSSGSGLGSTTTTSTSQSTRTAGTNTTATTAAVRQNSTSLHIRHLQGSDSVLFESFCGWVKRKLLNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YH16</accession>
    <name>A0A0D1YH16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234482.1">
        <property type="nucleotide sequence ID" value="XM_016381380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YH16"/>
    <dbReference type="STRING" id="91928.A0A0D1YH16"/>
    <dbReference type="GeneID" id="27334131"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07048"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OrthoDB" id="4114637at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF1">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="26"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="366" mass="38751" checksum="01B15B46598342DA" modified="2015-04-29" version="1">MPKEEEAVIEMEIPKEGWAAVVKNEGADFFVATEKVPVPFIGSTEVLIKLNVTGLCLTDVHFMMNDWAFPKMSDMGVSCAGHEGAGVIVKIGESVKSCKVGERAAYGPIHSTCSLCDSCKSGRETYCPQAVYTGGTVDGTYKQYCAVPEQFVHLIPEGVSDYVAGPAMCSAGTMYASLRESGLRAGDWAVFPGGGGGTGIQGVQLACAMGIRPVVVDTGKSRQSLSLSHGAECFVDFVTEPDPVKKVLEVTNGGAHGVFVCAVQAYPVSLNYLGSRIGGIVMCVGLPPKGRYHIDADPTQLCLNNQSIKGTLSSSRKDIAATMDFAKRGKINLEPVVVGVSKFNEAVQRLKNGQVAGRIVVDFNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YHE7</accession>
    <name>A0A0D1YHE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">O-methylsterigmatocystin oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234577.1">
        <property type="nucleotide sequence ID" value="XM_016381475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YHE7"/>
    <dbReference type="STRING" id="91928.A0A0D1YHE7"/>
    <dbReference type="GeneID" id="27334226"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07143"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="61112" checksum="CE1E74728C59AFC0" modified="2015-04-29" version="1">MAFAAAFFGVCLVFILVYSALQRKKPPKSLRLVPGPRGLPILGNLHQLPPYPQQSLQRWAREYGDMFQIRMGWENWIFLNDPAVVKELLDKQSAVTSGRAPSPVASDIISGGKRFLFMSYTPEWRKLRTIVHKLLTPKASALFKPSQELEARQLIYDIHEDQARNDQESFYMHCRRYSTSVIMTSTYGRRVPQWDCEDVREVYTVMNEFSEHAAPGAYLAEMIPPLAKIPVPLQWWRGRALKCYHRQLNIWWKYWTTLKQQIADKTAPECFVKQYVATEYEKEGIDEEQSAFLAGSMIEAGSETTSSALNSAIKYLAAFPGAQARAHEEITRVVGDSRSPGFDDEDNLPFLRATVKEVLRIRPVTNIGTPHYTTADIVYKDFFIPKNTVLSINQYAIHFDQRRYDEPEKFKPERYLDHPLKAGAYIAHPDPYARDHFGFGAGRRGCPGLHLAENSLFITLAKILWAFEIKPALGPDGKEEVVDVSDAAYEDGSNTVPRKYKVRFVMRNEKREMVLKEEWDETLRALKSPSSVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YK39</accession>
    <name>A0A0D1YK39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235567.1">
        <property type="nucleotide sequence ID" value="XM_016379740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YK39"/>
    <dbReference type="STRING" id="91928.A0A0D1YK39"/>
    <dbReference type="GeneID" id="27332480"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05397"/>
    <dbReference type="HOGENOM" id="CLU_014280_1_1_1"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000557">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="436"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="533"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="660"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="660"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="705" mass="78963" checksum="72E97EEEA4383BED" modified="2015-04-29" version="1">MAQRDEREGLSPSPANILDIFTGDEDDDDDIDSFHPTEEQSTDASQQDEDDSDADFADAHESLNGIEIVLETGDDDDYEDEDGEQTETENTGLAAHGLLTTADIRGLLNASAPLRQLILSRYRLLGPNGRDLFGDDDDDDYEPGYGGFSARRRRRGRPKPAPDRFPKVPSDAGRALMNSGIYGSKDSHIDTLRKRKQTISERLLWRRLGLDARSSMRKQNRLIAQNSVPASSVADKIIHYDSRAYSGQFSDDGNFFFSCTQNFKVRMYDTSNPYEWKYYKTVDYPFGQWTITDATLSPDNKWLAYSSIRHTVCLAPTDPTDHSEHTLLDFTNFAPGAGLGRSTYGYMGRHGFGIWSLRFSGDGREIVAGTSDHSVVVYDIERRQSTVRLTNHEDDVNAVCFGDKSSPHILYSGSDDQTLRVWDRRSMADGRPAGIFVGHTEGLTYVDSKGDGRYVLSNGKDQMMKLWDLRRMISPNDFQNIAMHNYTTNFDYRFSPYDEDDYVPNPHDCSVVTFRGHSVLKTLIRCHFSPPGSSNSRYVYSGSEDGKVYIWNMDGTRKATIDVFAATKFARSRTDGGDGYGYELHGHHNSVWKTCVRDASWSPTAPVLAATSWNGWGMATGTVSLHCWNDGAEDDEAKPAMGSNYNARLDPREDFDAAARKARNVDKYTRSRAEGRGLRSSVVRPHRYGEDDDDDDEGGGGGGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMD2</accession>
    <name>A0A0D1YMD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236397.1">
        <property type="nucleotide sequence ID" value="XM_016380570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMD2"/>
    <dbReference type="STRING" id="91928.A0A0D1YMD2"/>
    <dbReference type="GeneID" id="27333315"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06232"/>
    <dbReference type="HOGENOM" id="CLU_018409_1_0_1"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="324"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="686" mass="74113" checksum="A810F6EBB2E79187" modified="2015-04-29" version="1">METDSASTFNAKPPPLNSDQLNYLIWRYLQESGYADAAVKLQRDWKVDAENLSFAKNIKGHALVHLVQKGLRYHHLSLTIDENGRPSKQLNPTMFFFGPESNEPPPELREESIPAPSPAPSSSTARKGGRESVPNGLTENVAHSAPKRSRKPAPGSERNGSVARKPSGTTQPTGPDVDMVNGHPASIADARSPSATEGGPDESGTLANGDRMELDEESLIADNQHHDANTEPVAPLIHTLTNGASIGVQVAPAKVANLTPSTTYLSTQENGSMAITKPLTRVAWRAADSNVMTAIGDDFCGIWNLSNPPFGPKHQPPFQELMESSDSTIVSAVAWEPNGEMLAIATYSNQAGQIHLFDGQELALMETLPASQRAITSLRWQSQGLRLLGIAPYESESSDSPQHAGSSILLWDLSRSPNFTGPLSVSVPEVLVDMDCALLDGNGVVCATGQRAVYLCHAFTDLVLQQKWSSDAAENESWTFVRCAWHESSVATLVAASAETGSIWLPVQNLIKKSAHEAAITGLEIRPRLGSATPSLKQDFATSSMDGTIKVWRWDQESNYIMSICKLIIGYASPVMALSYSPDGFCLAGASYDTIRIWNAEHAYNHMATWKGEAETWGGGRLRDDDMVSLGGASSINGETIQANTDHSLSWDVDSKKLAFGLGAQVRLYPICFIPRSSSDTPRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMF7</accession>
    <name>A0A0D1YMF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_06267</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236432.1">
        <property type="nucleotide sequence ID" value="XM_016380605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMF7"/>
    <dbReference type="STRING" id="91928.A0A0D1YMF7"/>
    <dbReference type="GeneID" id="27333350"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06267"/>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000003">
        <property type="entry name" value="Elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW16216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="822" mass="90906" checksum="42621336DB8C693F" modified="2015-04-29" version="1">MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAITLYAHLPDEEDLKDIPQKVDGNEFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVIINKVDRALLELQVSKEDLYQSFLRTIESVNVIIATYFDKALGDCQVYPEKGTIAFGSGLHGWAFTVRQFAIRYAKKFGVDKSKMMERLWGDNYFNPKTKKWTKTGTHEGKTLERAFNQFILDPIFKIFDAFMKGKTDDLVALCGKLDIKITNEEKELPGKGLLKAAMRKFLPAADALLEMMVIHLPSPVTAQKYRAETLYEGPSDDPACIAIRDCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVRSGMKVRIQGPNYVPGKKDDLFIKAIQRTVLMMGRTVEPIDDMPAGNIIGLVGIDQFLLKSGTLTTSETAHNLKVMKFSVSPVVRRSVEVKNANDLPKLVEGLKRLSKSDPCVLTLITESGEHVVAGAGELHLEICLKDLEEDHAGVPLKISDPVVSYRETVGGKSSMTALSKSPNKHNRLYVIAEPLSEEVSKEIEDGRINPRDDFKARARILADDHGWDVTDARKIWAFGPDTTGPNLLVDQTKAVQYLNEIKDSFVSGFQWATREGPIAEEPMRSIRFNVMDVTLHADAIHRGGGQIIPTARRVLYAATLLAEPALQEPVFLVEIQVPEQAMGGIYGVLTRRRGHVFSEEQRVGTPLFTVKAYLPVAESFGFNADLRAATGGQAFPQMVFDHWQILPGGSPLDANTMPGKIVESTRTRKGLKPQVPGYDNYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNI6</accession>
    <name>A0A0D1YNI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rpr2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_03839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236867.1">
        <property type="nucleotide sequence ID" value="XM_016378190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNI6"/>
    <dbReference type="STRING" id="91928.A0A0D1YNI6"/>
    <dbReference type="GeneID" id="27330922"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03839"/>
    <dbReference type="HOGENOM" id="CLU_079140_1_1_1"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17189" checksum="4FB7EF38A1F80EA5" modified="2015-04-29" version="1">MAKAQASKKDGSNVPQKHLYSRLSFLHQAATLLTKAEGHPRTSHHEQSHLSDSSAKDTGSAEQGLPESTRLLSHLRGVSRKSQIRIAPELKHAICKRCDCLLIPGRTSTEIIKNDSRNGNKTWADVLEVRCNKCGTTKRFPVGAIRQKERPTEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQZ0</accession>
    <name>A0A0D1YQZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237862.1">
        <property type="nucleotide sequence ID" value="XM_016379185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YQZ0"/>
    <dbReference type="STRING" id="91928.A0A0D1YQZ0"/>
    <dbReference type="GeneID" id="27331924"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04841"/>
    <dbReference type="HOGENOM" id="CLU_012103_1_0_1"/>
    <dbReference type="OrthoDB" id="2555519at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="672" mass="72177" checksum="BCBEF53B4A2DB302" modified="2015-04-29" version="1">MPLDKQTKANSSKPLTPTLSSNFRNVKTPLTPRLPGSTSSSPALSSRKEPFVRARSPGKVDQTATPLNNNVTPRSGARKSRFGTESPSTPVPVRESNNGFQGTPSQRPEAPRALRSHTQGLGISSPRLTASTPSLPKVGPPVVTVHRRVSGAKSMVDNNKDNSSKFFHADEAKSAVGSSRFDEGSRFSPARAQFFVGSSAYPSNMPSQVPQESPKNDLDEKFFRANDVHQLPAAKPPTPVLAATVQGLDTRHAANAISPPQSPKRSYKMSQPSSPRKIQLGPTPSPPGPLHTPIERPNSTAGGAVANTIDSPLVHRKSISASSATMTIENRTEGIRTQPPQPLDLGIMPGLSPRISGNNTLSPEALSPRSFSLASSNTIPTSVTSDTDGSEVVKPTSRPVSTGDMAIDQVTSPVQPQHDAASNARRERKVLDLEISNSSLLAINKTLERELRKQNGELRRYRRLSRSGRLSLATVRTASGQSAFSLDTVAEDGVEAEQMSELEDESDFDDMDDEDDSLISDGSGSLTNASARSRQRAKDEKRLMQDLSRHQQLLAESQQLSSTIKRCTTMTEELIRAGNKALDYRVGIGDVKLGGRVLNDEELDERGFATGSEEPEARQGLLSPGLAKAKLEETPFRTDEALPTLGTAQSGIASLEEVTALLESFSPVLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWN2</accession>
    <name>A0A0D1YWN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239927.1">
        <property type="nucleotide sequence ID" value="XM_016374651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWN2"/>
    <dbReference type="STRING" id="91928.A0A0D1YWN2"/>
    <dbReference type="GeneID" id="27327368"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00285"/>
    <dbReference type="HOGENOM" id="CLU_024238_0_0_1"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000193">
        <property type="entry name" value="Ab-hydrolase associated lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="261"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="712" mass="81935" checksum="0937C42ECF372111" modified="2015-04-29" version="1">MSQTQLRTRAHATVDYEHQAEKLSLDSGYNAHDDEAHGVAVQASFITPLDPVIETNDGNRLPSVPVQEAHKINILKARAEGRTHRPQAPRPRGLSRFDVRNVEENDVNRDELLRDDRASETSRLDEALPPSHTHPLFPPLPLYGPPTFLRNLQCVTFRITSFFLSTAFLLVVVLGAVFTTLPHLLNKTWLRLTFRDRHRERPFAEEEKRRAGLRREQDKEWAARKRRRVSDSSPRDNPLDQGKGRYAPLEGGPDKLVCDVGYYARRVGLDAEDFRVQTEDGFILTLWHLYDPNEYRPSPDTHRRSKSPKIFPEQKSSHQHVLTQFNDGERRYPVLLIHGLLQSAGAYCANDDDSLAFLLCKSGYDVWLGNNRCGFEPEHSLLPYKDPRMWAWNIRQMGVMDLPALISRVLEETGFEKLGLVCHSQGTTETFVALAKEQRPDIGDKISVFCALAPAVYAGPLIDKMYLKFMRVISPRMFRMFFGIHSFIPLMMTMHQVLPGRIYGFMGYLVFSFLFNWSDTRWDRGLRDRFFQFSPVYVSAESMRWWLGRECFTKQRCILATRELGQQEDVEDQSEEERREDAMSNAADRGRTAWYDKHVPPFALWVAGSDDLVDGRRLLRRFERGREPHVDVVHSKVIEEYEHLDVLWAMDAAEQVGKEVREVLWKTMPEDARGTCRKILGVNETSVVCVGQASERQEKATFCDSQVVEGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXW6</accession>
    <name>A0A0D1YXW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240337.1">
        <property type="nucleotide sequence ID" value="XM_016375061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXW6"/>
    <dbReference type="STRING" id="91928.A0A0D1YXW6"/>
    <dbReference type="GeneID" id="27327779"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00696"/>
    <dbReference type="HOGENOM" id="CLU_000288_2_10_1"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14131">
        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000377">
        <property type="entry name" value="Checkpoint protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="488"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="840" mass="92740" checksum="31BDAB0119AB3615" modified="2015-04-29" version="1">MAAYMSPIPAALAVTSSNPRRSQYRSTTRSAVNRAQPLPLSMASETNPRLSRNMTGDSSDDEDLAPIKLSAEAQAILGEDEPQLDAEKENLEPEPRVIRTTSTSRRRSKISPLEMLKASSPPQQRDGSPAPRVVRVTSSVRPAPAATLGRDGSFMYRIQDRSTALTNPETNDSETPGPRIRRVRVSGGNRLSRSPPTRPDTGDPQSGPAGTEPQSASRSNSPSNGYIHSSPDEENAMPPSTVARPRRGEDNGAQSTMRVRRIGGALLNRPVRRGMVRRASEEDEMPLDNQDQERAGTPEMEVGRRVREPLLADLPDDMLALQGSPKQIKVTDMSPRTASPEPMKQPSPKLSSARPESRHQLLPTPRSQEVARSSSKSSSSRRDPIFKIPPLPSTASGPGQENEPPPTFRRTKPSPAVLEIHEDRPKSEKKQLDHVSPSRQPLAAKSHNTPHRPAPAPPPKMSILDAATSNAGSRNKRSVHYVLNGKTYRRLDCIGRGGSSRVFRIMAENYKIFALKRVNLEDADMAAIAGYKGEIDLLKRLENVDRVIRLYDYEINEEKGVLNVMMELGESDFNKMLNEQLKSENARLDITFTRHYWKEMLECVAAVHKYDIVHSDLKPANFLLVKGQLKLIDFGIANAIADDTVNVHRENQIGTPNYMSPESLVAQHAPAGYGGVGKILKLGKPSDVWSLGCILYQMTYGQPPFAHITKQFERIMSIPNPKVEIAFPGTGIGGAVVPFGLIKTLKRCLTREQSLRPTVEELLSDGDPFLNPVAISPDMLGRVIGNVVGYCRRREESMRARGEINAPEGVSCLPKDEEMKGWPLAFYEKLRQAQEEGTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYL7</accession>
    <name>A0A0D1YYL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_00956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240597.1">
        <property type="nucleotide sequence ID" value="XM_016375321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYL7"/>
    <dbReference type="STRING" id="91928.A0A0D1YYL7"/>
    <dbReference type="GeneID" id="27328039"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00956"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_1"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05917">
        <property type="entry name" value="FACL_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="74"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="528"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="629" mass="69015" checksum="127270E54B3D461F" modified="2015-04-29" version="1">MQPLFRPRRAIWQRRRSLIAALPLPLSDQPHSFPIPASVAVSIPAARRHLLTTSRTRGPSQPPLLEETVGDNFARIVSAHGDRHAVVSRHQRKRLTYNELDLNSNVLARGLQSLGVKKGDRVCVSLGNNLEFATITYALFKLGAILVPLNPAFTAAQMISAFNHLSATHLVIGTETNLPFKPPRSNVPILEAIVPDLTAATLASEAIPSLKNIILVDNSSGRVDAAEFRATRPWSSISQDTDTRPPTPDAPLSNREVVNIQFTSGTTSMPKAACLSHRSILNNGQQIGDRMLLTPDDVVCCPPPLFHCFGCILGYMATATHGSSIVFPTEAFDPLAALKAVQEEKATALYGVPTMFLSQLELIDDGVIANEGFQYLRTGIAAGSSIPAELMKKLHRVLNLTELTICYGMTETSPVSAMTTTDDPIEKRINTVGRLLPHVEAKVVDPFNHDRVLGIGERGELAVSGYLVMKEYWDQPEKTAEVMKADAEGKVWMHTGDEASMDEEGYVSITGRIKDLIIRGGENIHPLEVENCLFAHPKIAEVSVVGLPDQKYGEIVTAFVVRRHHLPSGESPITADEVRAWVKDRMSHHLVPKYVFFVDDYPKTASGKIQKFKLRELGVKLLEKGEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZR7</accession>
    <name>A0A0D1YZR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_01394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241032.1">
        <property type="nucleotide sequence ID" value="XM_016375756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZR7"/>
    <dbReference type="STRING" id="91928.A0A0D1YZR7"/>
    <dbReference type="GeneID" id="27328477"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01394"/>
    <dbReference type="HOGENOM" id="CLU_003824_1_0_1"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="10">
        <location>
            <begin position="704"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="5"/>
            <end position="6"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="50"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW20816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="918" mass="103256" checksum="3BC615C4477C8E20" modified="2015-04-29" version="1">MSSMRGLVQFIADLRNARARELEEKRINKELANIRQKFKSEKLDGYQKKKYVCKLLYIYIQGYNVDFGHLEAVNLISATKYSEKQIGYLAVTLFLHEQHELLHLVVNSIRKDLLDHNELNNCLALHAVANVGGREMGEALSADVHRLLISPTSKSFVKKKAALTLLRLYRKYPGILQAEWAERIISLMDDPDMGVVLSVTSLVMALIQDHPEAYKGSYIKAAQRLRKIVVDGDISPDYLYYKVPCPWIQVKFLKLLQYYSPSEDSHVRDIIRESLQAVLAAATETPKNVQQNNAQNAVLFEAINLLIHLDTEHQLMMQISSKLGRFIQSRETNVRYLGLDAMTHFAARSDTLDPIKRHQSIIIGSLRDRDISVRRKGLDLLYSMCDTTNAQPIVNELLKYLQSADYSLREEMTLKIAILTEKYATDAQWYIDISLRLLAMAGDHVSDEVWQRVVQIVTNNEELQPYAAQHIFEYLRTDNAHDTLVKIGGYILGEFGHLIADNKGCSPIEQLMVLQTKMISAPDATRALLLSTFVKFVNLFPEIKPQLLQMFQFYSHSPDSELQQRACEYLAIATMPTDDLLRTICDEMPPFSERASILLQRLHKKSVGISERRTWLVGGKDANADKQEVLLAQQTGLKRTFTTIVNGGAKSNTNGTAPKNVTNGTGTASKDLEGLDMNGHAGDAPVTNLADAAHLSPDWEIGYEQMYFANEGVLYEDPQIQVGMRAEYRGHLGVIKLYYTNKASFAIGSFTTTLDNKSAPALKIDTKSLPDSNVGADSQVQQTIVCTSIAPFSESPTIRISYLAGALQGYTLKLPILAHRFMDPSELSAEDFFKRWRQIGGGALEAQSTFGLRTPATEMSDKFTRETVLGFRWRILDNVDPNPKNIVGCAVLQLEKGKTGCLLRLEPNQQQKVCLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z053</accession>
    <name>A0A0D1Z053_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241152.1">
        <property type="nucleotide sequence ID" value="XM_016375876.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1Z053"/>
    <dbReference type="GeneID" id="27328598"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01515"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_5_1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000050">
        <property type="entry name" value="Related to histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000099">
        <property type="entry name" value="Sensory box sensor histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="544"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="748"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1052"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1193"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1269"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1426"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1195"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1278"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1465" mass="161419" checksum="C947E1A796E7770D" modified="2015-04-29" version="1">MVGRDHGGATQVPWDSHGKEGPLQTLDGDTTTTRVFDGTATQKGRGVDTDESHIEVSQLPQSTEVALAALSTLPTPLLVLSSLKTVILANSAAGRLLGVEQDGGDTNVTDILRGQTLSQIGIDMVSEGIPIWVSWEKFLDNLADGFEATSRQNSSPGELLPGLPSRADAPTGSPDARRAQPPLRSRTKKRPDTVVDVTMSSPKSAQHHRRHPDKTAQGRRQAVRASCRMIISIWSLEGQQFFTMTFTSLPSSHRHHHHNKLHAQAQSVHRKPSSNSAESSQSSQSQTPTSSASGPSSNANTPSENSSTGMTFPPNTTLAQCDPSSALTDFQKVLKMKNAMLNAVEMPLVAMWKDESVVIPNLAARRLLSIDADPTSDDSYDFLSRFRPWSPDFSHELSENNNPIIALCRSQLPFTNWQIGMINKRTEKKSIFDVSGHPVFDESTGEFLAGLIAFKDVTSYTDKLASQAAEQEDWFRLICDMLPVICWTTRPDGYNDYFSKRWYDYTGLQKADTEGFDWHAPFHPDDKVEAFRLWKNSLETGQKFEVQYRCRKKDGEWRWMLGNALPLRDHTTGLIVKWFGSLTDIQDIIDAKVAQQEARQNLVDVLRHSQMSVWIVDHRETVTFWEGDFMTGHDGASEIVGKPIDQAFRRYVNQNSITEFREAIRRILRGRSDLEICETELRSRWFRSKLIPLKGSGEGRGENTISGVIGIGSEVTQLRRKELENINLLANEAAAKEASKMKSSFLANMSHEIRTPIAGVLGMSELLLDTTLDEEQSEFAQNIQRSANSLLTVINDILDFSKIESGRLDVEEVRFSLSVVLQDVTKMLSYAARRKGLDFSSDIDLGPEERLVLLGDPGRIRQILMNLLTNSIKFTSDGYVKMSTHIIDETADTATVEFCVEDSGIGIEEEVKKRLFKPFSQADSSTARRFGGTGLGLTICKNLVELMHGKITLDSNLDAGTKATFTIPFKKVEYSANSSTDLLDVALIPERLQSELSLSLTGSSRDESRALSHASSATKMKLPLSLSAHARSGTDPGIAEESTEDIDRRKFHILIVEDNPVNQQIALRFIRALNFSASAVWNGKEALEYLLKATSPNLTPEQAEDYPIPSLIFMDVQMPVLDGYHATHLLRRHAPFTTIPAIGRIPIVAMTASAIQGDREKCERAGMDDYMAKPVKRSALEKTIIKWILSGRANGDNQTRPSENRVGSTKPVFTGASTDHSSTCSEHDIIAMELFAQCIPQPEAVEAASANTADVARARRSSISRVILESEIPGGESEGDRTRRRADAEDKARSLRDAKLLFATELGRSPANITPRVVLNNKELPNGTPHSPAIGDSFSRMALTEENVSLLNHTQDLDPSQVENDCSEIAVDDETYTMPEIPGPPPGLAATIDLAHPDTTTAAAVQSLLETADISPVVEVLPLTVASSGEDSPRRNRVDFGGLTADRRHLSDWSSSTAKPDSKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z1U3</accession>
    <name>A0A0D1Z1U3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241842.1">
        <property type="nucleotide sequence ID" value="XM_016376566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z1U3"/>
    <dbReference type="STRING" id="91928.A0A0D1Z1U3"/>
    <dbReference type="GeneID" id="27329289"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02206"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_2_1"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW21626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="309" mass="33648" checksum="02F03ABCCA160129" modified="2015-04-29" version="1">MAKRILVTGATGNQGGSVAKLLIKHPDQYVVRALTRHPSSPAARSLSDAGAEVVKGDLTDPSTLPAAFNGCWGAFVVTNFYDSSIQDDPASEEEQGKNAAKAALAAGVQCFVWSTLPSSLEISGGQVCCEIYEGKHRVDGFIRSIGLPAAFVYTGNFYENMILRGHVKKSQDGKGLEFRQPIIAENTRLHMLWVQRDLSAVVKAILDHWETKKAALLHQHLYAMDAIHTPSEVCATIERVAGVPTKYVILPKTGNESRDIMFNLYNKTGTYPGVTLPDPKVLGLGVKLHSLEQFLLEDLVPYLKTTGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z9K0</accession>
    <name>A0A0D1Z9K0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_12103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847512">
        <property type="protein sequence ID" value="KIW09647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229863.1">
        <property type="nucleotide sequence ID" value="XM_016386410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z9K0"/>
    <dbReference type="STRING" id="91928.A0A0D1Z9K0"/>
    <dbReference type="GeneID" id="27339186"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12103"/>
    <dbReference type="HOGENOM" id="CLU_997594_0_0_1"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="102"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="279" mass="31652" checksum="C27E1A9804949F3C" modified="2015-04-29" version="1">MDWRTVLAINDCLSTLVLSKTAYVNNLRRFLSAPAEADNELPRINTIRTYLRVLNRSGSSEATELFSRDETFRRLQMGLATEEQDQVNRQLQTYLAIFRWRCPFDILHTWQFDGVNADLAVRARQTFCPGQTIKGLEGRLVEAPEEAVEQQRQADMVSSIVESERFGQTFFMTSLARFVNHACDPNAKLVVRSRRYVDVVAIKEITLGEEVTVHYGSGYFGSDNQECLCRICKAPSRSSRPVPCSHCGWEGEDVECSSAPCSFCVRHFSIYGNPWPATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z9Q4</accession>
    <name>A0A0D1Z9Q4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_12050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847504">
        <property type="protein sequence ID" value="KIW09707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229923.1">
        <property type="nucleotide sequence ID" value="XM_016386357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z9Q4"/>
    <dbReference type="STRING" id="91928.A0A0D1Z9Q4"/>
    <dbReference type="GeneID" id="27339133"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12050"/>
    <dbReference type="HOGENOM" id="CLU_937003_0_0_1"/>
    <dbReference type="OrthoDB" id="3268967at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW09707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="297" mass="33485" checksum="BC7F4B43789DF83A" modified="2015-04-29" version="1">MEDNLDEISAQGSVAYRPQGKRIRVIQQFVETILEDDTASEPPRQPSEQDEEVHLYDFIGAVGIQKDRRGKKSVRYHVKWKGYGIKAMTWEPEGHIFEGDLLKLWSKYGRIHVRKQKGRQRLRHSMRQIHQCPSTEAHETNVRETDQVDHVTPSRSPEAVEAPCEQNFERDGGCDGLLLSKEPNAPAESDGADARGVSRCTSPPLSHHSPAPSQQGFDRLGDAHQHTLEIIPQLEVLETSQGLLNEEVTPSSQSDIHEINHTERIDPASVVSDVSVHYASISHDKKKSEMRRTSPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZD68</accession>
    <name>A0A0D1ZD68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_10226</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231143.1">
        <property type="nucleotide sequence ID" value="XM_016384541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZD68"/>
    <dbReference type="STRING" id="91928.A0A0D1ZD68"/>
    <dbReference type="GeneID" id="27337309"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10226"/>
    <dbReference type="HOGENOM" id="CLU_001867_1_0_1"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000272">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="111"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1069"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="851"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="935"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="880"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="961"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW10927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1258" mass="140969" checksum="E1B50C66D23E0F30" modified="2015-04-29" version="1">MDDQVEFDINESLKLYLSDSAKIPTPEASSELLDCENDPDSLTSDLVNNALDPVIDAIAENPEALGRSVIFDTLLFLLKYAFSHPYYHMKALRDSSAKRVQSRQSSVLSTQSLSKILHLIVSGLATTADVANHDIENDEQDTITQHKRLLEMYAFLLQWAISGVEAKALEKSNSAPPRRGGKGAKSKSAAKDDVWDSAGQVQGAMDVMCRVMKLKLNRIFQTTSDRDTFVNLFTRSVYLIMESEARVKTTPVRMFCFKVLCVAVKHHGHALGAQTSIVQNLTYFEHLSEPMAEFLHILAEQYDYHQLSAEILRELAAKEFSQNDTKGPKSVSTFIIKLSELEPRLVIKEMGLLAKFLDSESYTLRCAVIEVCGNLLADLSKQEEKSETTKIQINAFFDTLEQRFLDTAPFCRVKAMQVFTKICDLEQKFPKRRQHAAELAMQSLQDKSSNVRRNAIKLLRKLVASHPFSVMHGGQLSRKDWVERLEAVESQLEALQPPPEEAGVAQMANGEERVDNELLDDATQNPDAQADEPEEMIEEERIEAARKAAEEAATSEVLGKLQLTRKYYLEALRFIDVIHDSSDFAVQLLSSPNKTEVIDVMDFFVTIDAFKIETARQGIRRMLRLIWTKGNSDEGKGIQTHLIENYKGLFFDAPDMFTANDSANFVARNMISLTFGATPAELTSLEQLLATMFKAGHISELVVSKLWQVYGVNKEISKSQRRGAIIVLGMIALANPEVVIREIDTMLRIGLGHLGRQDFVLAKFTCVALRRMIPVAKKAQEKTASAGLSRMSNNHEVLRMLASILLTTSPSKDWYGMAEQAISAIYVLSDHPDVLCSEVLRQKTRLVFQQTKTMSSLSRTPSPEPPQEVEAMDVDEAEEGDNKPGPEEPEASKEGQEKPSLALSQLFFTVGHIAIKQIVHLELCELDFKRRKHEQEKNKSMASNTLPDKSAGPTPARRKKTAAEEVLAEKQKEEEKDELDMIGGTTEDDFTEAIAHIRERELLYGQNSLLANFGPLVTEICANNAAYKDRELQAQATLCLAKLMCVSSDYCEKNLPLLITILERSTDPIVRSNAVIALGDMAVCFNHLIDENTDFLYRRLNDGDESVKRTCLMTLTFLILAGQVKVKGQLGEMAKCLEDGDKKIADLARMFFTELATKDNAVYNQFVDMFSVLTQDGPLEGGVMEEEAVKRILKFLCGFIEKDKHAKNLADKLAARLGRCVNKRQWDDTAYALSLLQHKNEEINKKLAEGYRVVESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZLX7</accession>
    <name>A0A0D1ZLX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234063.1">
        <property type="nucleotide sequence ID" value="XM_016380961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZLX7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZLX7"/>
    <dbReference type="GeneID" id="27333710"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06627"/>
    <dbReference type="HOGENOM" id="CLU_001866_0_0_1"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="91"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="790"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="988"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="801"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="826"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1018"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1133" mass="125565" checksum="FFF573C840D26B0D" modified="2015-04-29" version="1">MVDTVDARLLQCRLGVTGGNRTVKSVYGDKSWVEDLDIVNELGAHTGCVNALSWSRSGSLLASGSDDTYLNIWDYNPASDYKPFTLNTSVHTGHHANIFSVKFMPHSGDRTVVSCAGDSEVRVFDLEYAGAARSGSTASSFSTSTRSRRFNNFFRNARWLNEANTNARVYRSHADRVKRIITESSPHLFMTCSEDGEVRQWDLRQPSSAYPSPRGGRAYGDVPPPLISYKKYGLDLNTISCAASQPQYIALGGAHLHCFLHDRRMLGRDLEAEQGRPASRNPIAGTYEDESMAEATRCVKRFAPNNKRKMGLNDHGHITACKISDANPNEMVASWSGDYVYSFDIVKSPDAREAGDKADKAFQAARLRNRSEGNRKRTRANVSSTSLAEAASPSRRLRRVPDDSLEEGRTALLARYTDGNSELIPIPHEESARNVEPASSNELLLTEAQRVAEQVARSVVQLRKTLFDFSAILSQQTAASVENSSDLTPHTASFTTALGQCAALLPQMDEIIRTWSYPVNPSEDDVTFQNTLRYNRLATWRFVQGTGCLARTLGGTLQSLSLGPDVRLSQFHVIRPPAHEGKNISKDSQFCYDFLKAILLWIDGGQEAVLDAFKRPGHVSSDSRRFPLDDDDTVNDYIPKLESFLLELAEDDVPVVDIDTNRFERDDTRLIFPSQVSAVQTFIGALTNVKLQLNQGMSAPSEGTDGTTRIMDKGAAARFWGVKVGRSLLMRAGEGINFDFVNRVFGGLRFHIVPDSGHERSQEDVDPDEADRIVESLDVITGLDVAAHQLASGSSAGSPETVRDTTEESERSDVEMRTFPTVHVEDADEDEEGDEDEDEDDNPDDQSDSDERDSDDDDDEGEYAVNPVMYHRRVGGGFRQRATVNLHVPYSSHSRIYKGHCNTRTVKDVNFYGLNDEYVVSGSDDGHFFIWDRKTCKIMNILKGDGEVVNVVQGHPYEPMLAVSGIDSTVKIFGLGGDSRERYNAAQGIDVANPGGGEHSSLRFGGRRRRRRRMGYGGDDEDSGDDDDDEENGTSANGGLASRRAMQHEYTITSQNDAARRQGAGETFVTVGYHRVLAVRFFGSEIADFCWLPRRSPCSLDLLWLCNEVSSTRFKDKGSVAKVELSWWMTTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZN00</accession>
    <name>A0A0D1ZN00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234428.1">
        <property type="nucleotide sequence ID" value="XM_016381326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZN00"/>
    <dbReference type="GeneID" id="27334076"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06993"/>
    <dbReference type="HOGENOM" id="CLU_450570_0_0_1"/>
    <dbReference type="OrthoDB" id="4161573at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="606" mass="67791" checksum="665F2ACD614DC2E0" modified="2015-04-29" version="1">MALQRADQQSIVYSPAHTKAQMSAPANFDQFDPSKIKPRKIKKSGEWGPRGPQESRYGIYWYNRRNDNEPMVWAELPSYPKFDEPIPATASLEEICEKYPNHVRGSYLEAFLQWRWSATDMWKYFTDHAKAELHTMGIARCRAAHNRCNFLFKRLAAHVRRMSIQKFRALCEAPKLRPALKDGRAKYGKSILQQKVLGDLGEPNWQPPFGVGQSHGLLEQNESVHSNMPTKSCAADVTPEVEKRTDPDPELEIFSKIMGLSFMEQISHCATIIKADPLCATHSNEQRRRWALSMLDIPVNAATETFLQYKAIWTCPAYLSWVEKKIEAVMERRKANDPLTTDARLPLTEKVLNPEVRQWIVDRKRATSQILEERHTISTILKSHAKHVGACPELSPDRHHRGLVIRVINQVLLAVGEIPTTWPGKDIPDGNAVEQVFEPTWTLPEQLAAALASQSAVLAADAEGNLYGDDEVTSSLTATGDTGFAYPEIPVDPDLTHQLRCGGGPGQFCGLLPSQLVEIVDPEHRTDPSIQDWTAITPDMWTAANVSGNVSTDFIGTSPTETMQPSGLAFFGFDEQGETTELPPSPEGLAILETDPEWLRVLVRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZP11</accession>
    <name>A0A0D1ZP11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_07291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234723.1">
        <property type="nucleotide sequence ID" value="XM_016381621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZP11"/>
    <dbReference type="GeneID" id="27334374"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07291"/>
    <dbReference type="HOGENOM" id="CLU_032067_2_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW14507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55177" checksum="C54525521A96DD9E" modified="2015-04-29" version="1">MLAVQGSAGGYDTFDVAIVGAGISGINTAYRIQSGLPGTRYTIFEARDSTGGTWDFFKYPGLRSDSDLFTFGFSWRPWLDTNPIATAPSILSYLKASAVTEGIEKHVQLNTRVQSAKWSTKTQVWTLTVASGTVTRRVHAKFLVLGTGYYDYEKALEANIPNLDTFTGRVVHPQFWPSDLDCTDKSVVCVGSGATAVTLVPVLASQSASVTMLQRSPSYVVSLPNPRSASLLLRWLPRRLSYTLNRLYFMIMPMVFYYFCRMFPKTSRNMIRDNAAKQLPENYPVDPHFTPRYNPFDQRVCFAPDGDFYAAIHSGRAAVVTDSIETVVEDGLILKSGGKVSADIIITATGLKLQLGGGIKLTVDGTPVKFGDKFTWHHAMLQDVPNAVLIMGYTMASWTLGADATAFLLCRLLKGMRKHGLSSIVPRMPDTETPKAHPLMDLTSTYVQAATKDLPKTGEFGPWRRRANYFKDYLRVNYGDVSQGLEFWQGDGPVTGVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQN2</accession>
    <name>A0A0D1ZQN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_07879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235308.1">
        <property type="nucleotide sequence ID" value="XM_016382206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQN2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZQN2"/>
    <dbReference type="GeneID" id="27334962"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07879"/>
    <dbReference type="HOGENOM" id="CLU_003925_0_0_1"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12296">
        <property type="entry name" value="RRM1_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12299">
        <property type="entry name" value="RRM4_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000588">
        <property type="entry name" value="Pre-mRNA splicing factor (Prp24), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034397">
        <property type="entry name" value="Prp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="838"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="910"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="1120"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="783"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1071"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1195"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="798"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1195"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1210"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1243"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1265"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1277" mass="143369" checksum="C8D6CA6CDE2D15E9" modified="2015-04-29" version="1">MDINSLLSPSETPRSTSLTPSVESVKSPFKHVQRTHTGSSSQPAASSPLSRAILPPSSIPAHVRSPSQQPSHSSPLISPVPTATLSGHFSRSSSSQNIETLADLVSHSHPSKSTPPISSSHDSTDSQKSSASIFPRLTSAGTASNHRASFDIAMVETPQQAMRVDYSETSLPIESQQRLAELVAYVQETPSMYDAHKEIIKILHQGFVDHIYPSSSPNARRDPRTYELLSELRQARENFDKLFAVGEEQWLDWLQDESILAQTAEERVNVVDKCRRAVEEEYGSAPLWITYGDWVLHCYRWALDSPTDAEGEDGEAERLVGREVFDWKLVLDIWDKAIHSTKHDMAHSHEVWDKYMTVRFGDVGQKLSPADAAAALELFQARLRVPHAMWEQTFQSFSSFISANLPAEYESVMSTTLKESSMAKELFAERDTYESALRQAQANADQALEYSTFDQYIVFERAEQEKVAKKRNTKGRRNVKIVENTEFDMVSALYSRAVLRFPAVVAIWEAHFDYLVERSKSDLLPLLARATKHCPWSGALWKQYLLTSENAEVDFDETEKIKHKATSTGLLDAAGIEQALIIYDAWCGYLLRRTKRMEATEEDADVAEMGIRSSIEAVQSLASKQGASPDFDSSFRLQRKHVEFLKSQGRFDNARALFDETVAEFGKCYKFWLTFYEFELQKSVQMAFIQHKGEERLSTLWSAPFAVGVLKQGLQHPGLDEPQHLIDALLNHCEDYEDADELQHALGLARKVQKEVLERKRLESLQAESIAISSRKAEMQVASRTEDVANGLHIGKRKREDDIQDTDNKKRNTTADEVQQSVEDTLGQEDLKRDREHASILVRNLPDNVHETKIRQFFDSCGVVKHVKYLEDENSAVVEFEDADAATFALSRDGREFEGAELSVVLNTGSTLYITNYPATADEAFIRNLLRPYGEIISVRFPSLQKNKRRRFCYAEFKLPSEARAATELDGKEIDGLRIVVKVSNPAARHARIETNDDGRKIFVGQLPFKAKADDINKLFSPFGKLENIRVPQDPNARNRIRGVAFLTFATADQARAALAMHDQEFMGRRITVSQMEEKGRSSKQGSRISKSPSAQAGGADRANASAKRDISSIEDRKQRTVAITDVPDTVNESRIKAMAEKCGPVRKVVLKTNHQGALIEFEEIADAGRAMIELDGREIDPGRRIRVTTESDMLRQRAEHKEEQFAKRSVTNRPTNTPAQGPVRRPAQPGGRKGGHLGQRSAFLTQTDPKNEPATATSAPNGKRTNDDFRNMLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZR08</accession>
    <name>A0A0D1ZR08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_05297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235468.1">
        <property type="nucleotide sequence ID" value="XM_016379641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZR08"/>
    <dbReference type="GeneID" id="27332380"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05297"/>
    <dbReference type="HOGENOM" id="CLU_1294414_0_0_1"/>
    <dbReference type="OrthoDB" id="4161609at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW15252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="213" mass="23927" checksum="6A5E08EEB43B1845" modified="2015-04-29" version="1">MATFDFGRLDSSRYCINDPRGVRDFQVMVEDFINIAKVNPDVFNDKIGEIKEFCLIITDGDAWPLAQLVVPEFRVSQNHWVEDGTSPMHIILQSVKHKLPQPLSDSESSSPFRRGHWTDMLPAGLLYAPTRGRGVPPTIFEEPESDQEACQKNIDATCKVDLARASASLTGFLGPHNAEVKPGNHLQSMVTTLTSPTRRPKNVLRRKHSLWYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZR65</accession>
    <name>A0A0D1ZR65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235518.1">
        <property type="nucleotide sequence ID" value="XM_016379691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZR65"/>
    <dbReference type="GeneID" id="27332430"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05347"/>
    <dbReference type="HOGENOM" id="CLU_043557_0_0_1"/>
    <dbReference type="OrthoDB" id="3938221at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037738">
        <property type="entry name" value="Ecm13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826:SF1">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="490" mass="52888" checksum="1B5CCE309C92A654" modified="2015-04-29" version="1">MATAMTMHMPSSRTRPKPPARVNTSTTYTLAHTAQCKLRLAAKRTDRDLRFILGHAFTLDNLMLRIVEIENRQAKSAFAEGVGKKSREVSDAEDHFDCSLANTKTATAPSTKEHHDDGDFDCSLGNPDTAATTKEKHEDSDFDCSLAHPDTAPTTQEQHDDGDFDCSLAHPDTAATAKGQHDGDHDDDGEFDCTKAPPPEHDDDHKVSQRSSALGGGGDEASAPAGGRRISFQDNNARPSKNGYGYGHESGGSRSPRKGRRSPSPQPQHLVFPAGLSDDSDDGTSSDDYEDPELMAYDCEAAPPVPEEKKAIKRAKQAGSKKARDAYVDEEDAALELADDELDTNNNTDVDEDADSRLADNVKGARFGLGDDGEYDDDGDDDDDGMPGLTRFQSASARPPRMIEDVEGDDDDDDDDHIGPDSPPQLPADVDVREIIAGERDEELTDLYEKVRRCACHGNRDNVGGKAEGIWDVPVEKTGGKVLAVVAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZS69</accession>
    <name>A0A0D1ZS69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235863.1">
        <property type="nucleotide sequence ID" value="XM_016380036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZS69"/>
    <dbReference type="STRING" id="91928.A0A0D1ZS69"/>
    <dbReference type="GeneID" id="27332779"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05696"/>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF24">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="107"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="371" mass="39946" checksum="B5ACABA2DC8EFEE3" modified="2015-04-29" version="1">MGKLSQESKADLYEPDPNWTAFAEKNGYLSPDASSNDSFVLNVEGDRAAAAVSEAEFSKARPLSSFGYSWILSNVTVRDGASISVKISYPTSVSQEGATPTKLPVLFVTHGGGWVQGTHVSAESSTLWPLYDHFKLLIVSVEYRLAPEHSFPVWMDDSWDVLEQLLSHPATFLSSAAAAAAAAGSGDTAAALKNVQPDLDRVILVGSSAGGGTSAYLSQACRDRGLPIYGVVLNYPLVCDYRHLPDDCRLSYEQGTTNAALSSGEMRALWHLLIPSATAGTDLKASPLLGNLKGLGKHLVFVAGHDPLRDEALKYAEILEREGCDVQLFIYPGVPHGFTDAWELDASKRFAEDFRRGLSGWLGHDKVPGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZT48</accession>
    <name>A0A0D1ZT48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236173.1">
        <property type="nucleotide sequence ID" value="XM_016380346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZT48"/>
    <dbReference type="STRING" id="91928.A0A0D1ZT48"/>
    <dbReference type="GeneID" id="27333090"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06007"/>
    <dbReference type="HOGENOM" id="CLU_019101_1_0_1"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
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    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF166">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="26"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="321" mass="36438" checksum="D99A213289ADBEA3" modified="2015-04-29" version="1">MQITSNEARYGGWVCAGLSLAILIVRIVTARIRQGAFEISTVLCIIAMAMIGGRLAANQYILSYGTANDALHSKSHYFDSHNIDRIKTGSVLALIVRLLDTTFYWLQISLLLLFYSRIFEVRPRWITISIRTCWLAIALSYVAVVLATFLECRPFRLYWQIKPDPGRCVRAYIQVLTQAISNIVLDLMLLAISSPLVLVRNRSLSEKFRLGLLYCLGFFCIVVTGVRIGYIFAEASYQPVRSFWASVQILVSTFVANVPTIYGCIKLIRRRRSEQTARRGSRPEIWLQVQASNESNTSSVVPLFNRRSDGSFEKGWLRFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTE9</accession>
    <name>A0A0D1ZTE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016380421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZTE9"/>
    <dbReference type="GeneID" id="27333166"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06083"/>
    <dbReference type="HOGENOM" id="CLU_028344_0_0_1"/>
    <dbReference type="OrthoDB" id="4120541at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="659" mass="73039" checksum="78712C3F6C503266" modified="2015-04-29" version="1">MAPNLRDTDLFLSVKVDSHHKFTQPIIRTPSTASPCSDMSANTAKAATPDSSFKDPTKKLRHKRRFTIGGAGQRSGTVPHSPVPAIEKKQVAQDEIVHSRPAVTTSRTSSSRRSIPHTSLFKDDHERQLSRTPKQLQPDITDGARLSPKPTPVVVTDSPCSRSSRSKSPKALYPPSSWKRVEPLTFNLAEQTRFETPLISPSTDHAIASPRRPSLGRARHTEPVSAATAVSDVWTEIAGLSPQPPRRTLSARSHLPKQPMPAAQPLPTNQNIPADGKSILSQRFPSVTGVSEARPTPTVQNTRPRYIRSRRRSNPVAPPSQEHNLPAPEIAYADTFHYTNCEHTSPPMSRPLNTQPILVPYQHGLLAFPPFHIRDFLESQPTVTPSIYIIEGACSICDLAYRRKAESDILARYTTRSENLLLQLSLLQEDLDVKSPTALDLPERKNTATPFPTSSSRRNTTSPEPSTTSSITPENIQAILHMEEQAENLIKQRDLEVTAIWRGYTERWGPATVAIHHANDRIIRGRGRAQSASSASTFPEMDNISSLTSNFDNSTDRTSTMTSTVSTRTTQTNYTNAVLSSTTPRRTSLSRRTSRSDSIGPQDRYSDGTRIVNVPSSVDGVKRDGRMLVDWIRPDRTESGLRVRSRSHSQTRSTSRVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYL0</accession>
    <name>A0A0D1ZYL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237968.1">
        <property type="nucleotide sequence ID" value="XM_016379291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYL0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZYL0"/>
    <dbReference type="GeneID" id="27332030"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04947"/>
    <dbReference type="HOGENOM" id="CLU_073129_3_0_1"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF21">
        <property type="entry name" value="DNAJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="233" mass="25934" checksum="31B8A8ECA84B554C" modified="2015-04-29" version="1">MSSLPDYYAILEVPSSATADDIKRAYKKAALKWHPDRVPVDSPERPKRTKRFQAINDAYYTLSDVTRRRDYDDARRFHTTYADVEEEEEVDEDIPRTRRTNAGANTWSNFFSNFGRSGNQEEQFSNDQFESAFAEMMGEAAMADGEQQDAGAGQPKPGTFWAMLGGLSGATLGFIFANFAGAIPGAAAGWKFGRLRDEKKQPVYTTFQQLPQADKAKLLSELASRLFASALGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZS2</accession>
    <name>A0A0D1ZZS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238453.1">
        <property type="nucleotide sequence ID" value="XM_016376883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZS2"/>
    <dbReference type="GeneID" id="27329608"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02525"/>
    <dbReference type="HOGENOM" id="CLU_097061_0_0_1"/>
    <dbReference type="OrthoDB" id="3850374at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="1">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="108" mass="12559" checksum="8F9F8CAF32E45472" modified="2015-04-29" version="1">MIYELRIYTTVPGRLPNLLARFENHTLKIWEKHGIRQLGFWTTLVGPDSNDLTYMLAWESLAEREQKWNAFLNDPEWIKARIESEKDGAISAKMSNSFLVPTKFSASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A326</accession>
    <name>A0A0D2A326_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239533.1">
        <property type="nucleotide sequence ID" value="XM_016377963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A326"/>
    <dbReference type="STRING" id="91928.A0A0D2A326"/>
    <dbReference type="GeneID" id="27330694"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03611"/>
    <dbReference type="HOGENOM" id="CLU_167122_2_0_1"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="88" mass="9911" checksum="6F1A14809DB9945D" modified="2015-04-29" version="1">MENEKGEIVDLYVPRKCSATNRIIKAKDHASVQISVGKVDENGRYTGENHVYALCGFVRSRAESDDSLNRLAQRDGFLKNVWSAQPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4C6</accession>
    <name>A0A0D2A4C6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239918.1">
        <property type="nucleotide sequence ID" value="XM_016374642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4C6"/>
    <dbReference type="STRING" id="91928.A0A0D2A4C6"/>
    <dbReference type="GeneID" id="27327359"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00276"/>
    <dbReference type="HOGENOM" id="CLU_030742_2_2_1"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000203">
        <property type="entry name" value="Related to sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="50"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="460" mass="50463" checksum="2B935F0588B78724" modified="2015-04-29" version="1">MFNGRVVSAARTNVGRCTAKANKRQDVSSTIKRRNLASVAPVNSASRSHKVVVIGGGSGGVAVSHQLLRTGKFAPHDIAVVEPAAWHHFQPGWTLVGGGLKDKRDLRSPMKELFDPKLNFYNESVKGFSPGENFITLANGDKLSYEQLVVAPGIKIDYASIKGLPEALEDRSSSVSTIYGYETCDKVFDTIQRLKKGNAIFTQPAGVIKCAGAPQKILWLAVDFWKRAGLYDPANAANSPIQATFATGLPVMFGVPKYNAKLDEMRKELSVEGLFKHDLKSIDGDKATFAHVETGEQVSRKFDLLHAVPKMGPHDFVKNSGLTNEAGYVDVDDATLQQKKYPNVWSCGDASSLPTSKTLAAITSQVPVLVKNLVGAMEGRKPEETYDGYTSCPLLTEYGKVMLAEFKYGGEPKETFGNLLGIDQATPRRAFYHLKKDFFPWIYYEAHVKGTWQGPKGWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5A9</accession>
    <name>A0A0D2A5A9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_00537</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240178.1">
        <property type="nucleotide sequence ID" value="XM_016374902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5A9"/>
    <dbReference type="STRING" id="91928.A0A0D2A5A9"/>
    <dbReference type="GeneID" id="27327620"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00537"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW19962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="57903" checksum="02CB148DEA64590F" modified="2015-04-29" version="1">MPLFPFPSLTSCVLLATASVVAYTLILIVYRLVFHPLRKFPGPVFAAATYWYEFYYDLIAGPFPGQGVYNIERLHRRYGPIVRISPDELSVSDPDWFDVLYKSGRRNKWAKNSKANGSPGSIASTIPHQLHKARRAPLAPFFSKRGVDNLESVVRQKVDQLTHGIEEGYMKRGKILPVGVAFTALTLDVISDYCFGQSWRCLFAEDFAPEWKRVMTNLFEPVPIVKQFPILVQIMDALPLKVIKKLDPDMGLFHGAKRDVQRQVERVIAEYEDRAATPRTIFHTVLDSSLPAEEKTVQRITDEAYVMVVAGGETTAKTLTNVMFHLLANPEWLARVRDEVDSVMPDREVLPHYGVFEQLPYLSACIKETLRISAPVTNRVQVLDAEHELVYNEWVIPKETPVSMSVVAVHMDSRIFKDPYTFDPSRFLGEQAKISNAYYMPFHRGSRNCLGMNLAYAEIYLGTAAMVRRFNLELYDTVRERDVDTVRDCFVGMAVPGSKGVQLRVVGKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A751</accession>
    <name>A0A0D2A751_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240808.1">
        <property type="nucleotide sequence ID" value="XM_016375532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A751"/>
    <dbReference type="STRING" id="91928.A0A0D2A751"/>
    <dbReference type="GeneID" id="27328250"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01167"/>
    <dbReference type="HOGENOM" id="CLU_040671_0_0_1"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="42799" checksum="D5CB033BC76F0FCA" modified="2015-04-29" version="1">MANGAVVPIPPPQFPTHNAPRVWLLTSGDSPIAISVARQVLDHGDYVVSGIIQADFEDESVRSKEFKNFLSEVVQTNGWKDRLKIVPLDIRHVGQCQAAIAEAVHVFKKIDILFCCTSEAVIGTVEELSANPRTLTMVRDQFEKNFFGPMNIIKAVIPHMRSMMNGHIIVLGGITGHLGTPGLSMYCASGWALEGFCDSIAYEIAPFNIKLTILQASVEIGILTNKITSAPPMKEYSREFGHTAPMFRGILDGLLNRLPGIRSQYPPPPESEIQSPSSEAERQSGPYLLSRNEVFSLYPPLSHAHTEKLVAETVHALTAIGGHENPPARHIVGVEGVASVKEKLKTVSEELEEFVDTSASADMVKPGPGYGRASSVADVDFKDLEGSVFDASMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A799</accession>
    <name>A0A0D2A799_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="9">GAT</shortName>
                <ecNumber evidence="9">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">Ornithine acetyltransferase</fullName>
                <shortName evidence="9">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="9">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="9">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">N-acetylglutamate synthase</fullName>
                <shortName evidence="9">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="9">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_01224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="9"/>
    <dbReference type="EC" id="2.3.1.1" evidence="9"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240863.1">
        <property type="nucleotide sequence ID" value="XM_016375587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A799"/>
    <dbReference type="STRING" id="91928.A0A0D2A799"/>
    <dbReference type="GeneID" id="27328307"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01224"/>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_1"/>
    <dbReference type="OrthoDB" id="2017946at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023356239" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023356240" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="9">
        <location>
            <begin position="236"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="9">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="9">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="9">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW20647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="470" mass="49287" checksum="6E207B63C1BE2AA8" modified="2015-04-29" version="1">MASHSPARSMMRTFIRNYSAPVDSSIPANKVKYVPTSGTYPKGFRVSGTYVGVKASNTSKPDLAFITSDTPASAAAVFTTNKFQAAPVQISKSVLQARGGANLRGIIINSGCANAVTGKGGMDDAQAMSDTATAQFQQGAQPEDNLGSTSLVMSTGVIGQRLPIKKILAGIPTAYSNLDNDHNAWLTTAKAICTTDTFPKLLSTTFTLPSTAHKGTRYTLAGMTKGAGMIHPNMATLLGILCTDAPVSPGAAQSLLTDAVNKSFNSISIDGDTSTNDTVALLANGAASPSPDTPAIADDASNEDYAAMSSVLTSFAQRLSQLVVRDGEGATKFVQVTVRHAPSHADAKAIASTIARSPLVKTALYGKDANWGRILCAIGYTPGISPDAVVPSKTNVSFVPAETSKSKDEGVLDLLVNGEPEAVDEDRAARLLEDEDLEIVVDLGTGDEEAKYWFCDFSHEYVTINGDYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A9H7</accession>
    <name>A0A0D2A9H7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241633.1">
        <property type="nucleotide sequence ID" value="XM_016376357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A9H7"/>
    <dbReference type="STRING" id="91928.A0A0D2A9H7"/>
    <dbReference type="GeneID" id="27329080"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01997"/>
    <dbReference type="HOGENOM" id="CLU_074873_0_0_1"/>
    <dbReference type="OrthoDB" id="5597489at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="217"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="286" mass="30733" checksum="3887743831DAF38B" modified="2015-04-29" version="1">MNRKQRRNNKASTNHGGDSSFSITSADDIPLARPPDTRRTTRDGGSGAGASSGTARTKTLFEIAAERQAQLLGGQSGIENSKPIDPKNIVQVKIGQDGQIVRADGQPSTTSQPSSSLLTRFFGAPDDDDDSHTRSETPWFDTILLATSLSTVHFTLDVLTVHQYAQELLFRPIFARAVFTAFPTLAMVIALFRGLLFPSSLTQNTPPAVKRGISTLRQVACVLIANVAGCYLVALTNDKGYYAVMKDAPGVGTIWVWAVLELGLMGALAGVGGPAVYAWWNEYGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AA08</accession>
    <name>A0A0D2AA08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_02162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241798.1">
        <property type="nucleotide sequence ID" value="XM_016376522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AA08"/>
    <dbReference type="GeneID" id="27329245"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02162"/>
    <dbReference type="HOGENOM" id="CLU_000960_25_3_1"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW21582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="564" mass="59806" checksum="19D5570BDDEAE2F1" modified="2015-04-29" version="1">MESPPDQKSEVMHKEEEAQISSKHQGITGVDDESAQVVKNDDSDGHVNWTWKQIIATVSLCGVYVGSLTYIAADLGSASAGWIPVANSLALAAVCPFCGYLQDMFGKRNISILGSSLILLGVILTATTKSFAQAVAGMTLAGGGAAIGELTALAGVAELVPVKKRGIYLACVTFFIAPFFPYVLYSQLLSAHATWKWGMWITLIYNGIFFVGVLLFYFPDSRILRKGRLSRLEIAKRIDYIGAFLSITGIILFLVALQSGGSSRPWVSAYVLCMLFIGAALIAAFVVWEWKGAKYPMVPRDLFAGQRVVAIALAVAFVSGMNFYSMINFAPLTYSTVFDPDPIQVGVKGLGYSIAITVGASVMNAALTILKGHNREILLVSCVLMTAFTGSMAAVKPDNPGLAVALATVAGFGIGGVIVPSATIAMTACPDSLIATATALTLTIRFVGGSIGYSIYYNVFTEKLTSKLPTTVGAYAVQAGLPESSVAEFVASFLTAPATAANVTGVTPAILQAATVGSRWGYADALRYVWYVSIPFGVLSVVGCFLIGDISRFMTNRIAVQIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AU95</accession>
    <name>A0A0D2AU95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230226.1">
        <property type="nucleotide sequence ID" value="XM_016386094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AU95"/>
    <dbReference type="GeneID" id="27338869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11786"/>
    <dbReference type="HOGENOM" id="CLU_1704253_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="156" mass="16730" checksum="CD133A06477625F7" modified="2015-04-29" version="1">MAQQNTSNLKVILSKPPDWQTCADCKRAKAKCEPAADPQSCLRCQSKARPCIRSSNPHGGTTQSNRRNRKKRSDRVEGPPVEAGGSRVAAGPGQASQALSPASTDTNIQSNDTHENIPIDPRLLEADQENQNKDRDKGKGKAKAVDGDEGEGEDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AV92</accession>
    <name>A0A0D2AV92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230854.1">
        <property type="nucleotide sequence ID" value="XM_016385910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AV92"/>
    <dbReference type="STRING" id="91928.A0A0D2AV92"/>
    <dbReference type="GeneID" id="27338685"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11602"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_1"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF22">
        <property type="entry name" value="ENDORIBONUCLEASE FAMILY PROTEIN BRT1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="129" mass="13944" checksum="1CE7BEBA7C85953C" modified="2015-04-29" version="1">MSRTPVTTENAPKALPGIYSQAIVANGFVYCSGCVPMDPKTMQLIDGDIQAHTHQCIKNLGAVLEAAGSSLEHVVEVNVFLANMDDFAKMNEVYTTYWGDVKPARTCVAVKTLPLNTDVEIKCVGVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVN2</accession>
    <name>A0A0D2AVN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230696.1">
        <property type="nucleotide sequence ID" value="XM_016385752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVN2"/>
    <dbReference type="STRING" id="91928.A0A0D2AVN2"/>
    <dbReference type="GeneID" id="27338527"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11444"/>
    <dbReference type="HOGENOM" id="CLU_001490_2_0_1"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF445">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="377"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="3">
        <location>
            <begin position="765"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1060" mass="119079" checksum="8B22A0D9D234874B" modified="2015-04-29" version="1">MATIKARRDYLAWTEEPLNHHVHTLRAAPRPPLRFTSELYDDPAGPGLRHDNDRADYREIQILPTPDEILAVDCPVYMPKKDLRHKHHLPNGPGRHLDCLFRQMRCDRTESVRDIAYTAAQQAFLQVDPYGRPQPISHEQILCETLSGHRFFLYHDIKIEELLAHENKGLLVRASYHCPSFMKGQRMYGSGRFAEGMLVALLQLDLITNELSVSFLEVKFSQSTFSMDKAGGDGERAAVQMSFLPTSTREDVLQLSRHVLGLSTETQLALVEFPKVLFAGFYNCLKRLQEMGETDFAFQTYIAPTITPEDATSRMKQNIPSGAIPVVNCPPPAYARNADFEYDLSAVLSSTNRTKSMSVEELLRPSSIDVLRRETSLDEGQAIAFRDALVNELALTQGPPGCGKTFLGVQLTKALLSSRPTNKPILLVCLTNHALDSFLQDLLDAGVTGLLRVGSGSKEKWTQSINLQTLKRKSRFGHRSSEATILRTRKKEVFGDVDVMCKGTWISPFPFAPQIPRFTDIHQAISSKLNTGKVPWQYVEYILYEKYPSIHAQLSTNAPSAYAKSFAFEHWCGGGDLDTIRDLHVELARRLNEVLRERDRSSTKDSHTILQEVSQFIKQQTEHSGDSSIWNLPYSERQVLLGQWESEVDTERLASKLTDLHFEYKELNASAMELSCEKDIKIMGGCNVIGMTTTACATRWKQLASVGIEITIGEEAAEVMEAHTLCSLLPTVQHAILIGDPLQLRPETEQQMLALETQIGMDYRLDESLLERLMLPKDPSTFAVASCHLNIQRRMHPKIANIARIIYPYLKNHESTLDNPPTFGLVHRMYWWDHRIPELEADHLKSHVNPYEVEMVAGLVTYLLRGGAYDLGDIAVLTPYSGQLAKLHDRLSVTCNVWLSENDHQLLFDEELVGLAPERRAAKDKVSMSDMLRIATVDNFQGEEAKVVILSTVRSGGSAGFLNSINRINVACSRARDGFYIIGNTQTLSQVPLWRQVISAFDGKVVRTQNTVTLSSSLLTFSWSPSVLPCAANAWTVAMIAIRHATRHASTNVWPVKTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWX1</accession>
    <name>A0A0D2AWX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_10503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231419.1">
        <property type="nucleotide sequence ID" value="XM_016384817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AWX1"/>
    <dbReference type="STRING" id="91928.A0A0D2AWX1"/>
    <dbReference type="GeneID" id="27337586"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10503"/>
    <dbReference type="HOGENOM" id="CLU_028414_1_1_1"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="504" mass="55158" checksum="3FCDBCC9FE18901B" modified="2015-04-29" version="1">MNRPPSVPDARGTEQTAYTRNGSDSVDALSSGLATSDGGFVYSSNHLTATAPATPSNTEASSTPDNSFSSSRQQLSLMQSAQAPSRSGLDLTVPISVDPLSFMASNNRHLLQYFMHNASQALATHSLVHREVCEVIIPMAVANPALLHATLALAAIHLNSFMSNSDHRPRDEGSDVVAHLTTTSIAHLRRELQQPVGGSPGPQLATIRTLFLCEAISGSPTLSTWRSHFLGAKALFSSMERQKDIREFQKDASLPFLRRWYNITEALVALTPEGLEEDMQGSLGPRSLGDPSDTPICIDAYTGCTDDLAKALREIGALAWERRRATRPPNQPSKLSEADFLRKADGLEILINRMIIRDRSGTAISNVPEPHGLSLKQFEEFLLCNEAYQHTALIHIHRQIRLLSSDSSLVQDCVKRIIDCVSRIKPAATLSPLTLLTTPLFTAGCEARGSDRTKITLLLKEMYNHLHLPNMKQALEVLEDFWLASADGKTSWESFSSTLTLSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AX58</accession>
    <name>A0A0D2AX58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Branched-chain amino acid aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_10598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231514.1">
        <property type="nucleotide sequence ID" value="XM_016384912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AX58"/>
    <dbReference type="STRING" id="91928.A0A0D2AX58"/>
    <dbReference type="GeneID" id="27337681"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10598"/>
    <dbReference type="HOGENOM" id="CLU_020844_4_1_1"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000002">
        <property type="entry name" value="D-alanine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38001" checksum="5ED2DF63AB075838" modified="2015-04-29" version="1">MATMEKVFAAYNARKAALETTFETNRFARGIAWVEGELVPLSEARIPLIDQGFMHSDLTYDVPSVWDGRFFRLDDHLTRLETSCTKMRLRFPIPRDEIRRVLVQMVAKSGIRDAFVELIVTRGLKAVREAKQGEVLQNNLYLFLQPYVWVMEPEMQLTGGTAIVARTVRRVPPGAIDPTIKNLQWGDLVRGIFEARDRGADYPFLTDGDSHFTEGSGFNVLFVKNGVIYTPDRGCLEGVTRKSVIDAARMLGIEVRVEIVPVSLAYEADEVFMSTTAGGIMPITRLDGEAINGGELGPVTSKIWDKYWAMHYDDTYSFRIDYEKGMQAEAVNGFANGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXC5</accession>
    <name>A0A0D2AXC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231589.1">
        <property type="nucleotide sequence ID" value="XM_016384987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXC5"/>
    <dbReference type="STRING" id="91928.A0A0D2AXC5"/>
    <dbReference type="GeneID" id="27337756"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10673"/>
    <dbReference type="HOGENOM" id="CLU_048612_1_1_1"/>
    <dbReference type="OrthoDB" id="4106209at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="311" mass="35250" checksum="1397E6050DF1F042" modified="2015-04-29" version="1">MRKPSIPDLIYQRTFPKPKQGDPGSFFAHIHRHIVSEIRVEVQTFFGTIDTLEAQYPGLDYTYPPHRRRLSRHPWHRRLFRVIDELGLTDDEVLSLCQWEGTRAAKERYEREAQTEVKSTTGADVEAAPQGSGPRAIWEDWSRPRSSRTSSDNDTVTELEEREHKDGSPAVRHGSNEPPDDNVMGLVRDAMQARMEARSSGTPLIINQVWEQWLKEALERHEMDVDSVLTAIQSLDFEMISPVVEEDAAVGLTPATTPPLSPSQPTHAGQTRSYDDLHTMVDELQNNNTRLAEDNAAMALFLSRSQTEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYF8</accession>
    <name>A0A0D2AYF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231646.1">
        <property type="nucleotide sequence ID" value="XM_016385044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYF8"/>
    <dbReference type="GeneID" id="27337813"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10730"/>
    <dbReference type="HOGENOM" id="CLU_008455_8_5_1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010509">
        <property type="term" value="P:intracellular polyamine homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="114"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="569" mass="63249" checksum="53A4F9738E29C6B6" modified="2015-04-29" version="1">MARDSPEKISALPQTSVNPSTNEDNEKEAGEKHEVPSDVRSMNSTHSAAPSEQSTIGDSQDIEIADDVLQRTITPKSPLVKVPRSKRRGLFSRFALVAEVTQPFDYKDSTKWFITFIVAVAAAAAPLGSAIILPTLDDVAKDLNSTPTITNLSVALYMLSMAIFPLWWSMFSEVFGRRSIYIVSFALFVLFAVISAESQSIGMLVAMRMLSGGAAASVQAVGAGTIADIWESRERGRAMGTFYLGPLCGPLVAPIVGGVLGQHWNWRATQWALVIYGVLIWVFVFFALPETLKAQKEVVDEAENETSDQPGASLSRTSTREIVQQSSKKYLKVLKMLLVDPLRVILYIRFMPVLLTVYYSAITFGSLYVLNISVQYTFERPPYEFSTIIIGLLYIPNSLGYMLASMFGGRWMDSIMKREALKARRIDENGKLVFRPEDRMRENAWLGALLYPVALIWYGWTAEKGVLWIVPMLANFFYGVGSMLIFAMSTTMLTEFMPRRSSSGVALNNFCRNILSCVGAIVGAPIISGIGNGWLFTILGIWTLSGASVIWAMKRFGPRWREKMDRELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYT7</accession>
    <name>A0A0D2AYT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231801.1">
        <property type="nucleotide sequence ID" value="XM_016385199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYT7"/>
    <dbReference type="STRING" id="91928.A0A0D2AYT7"/>
    <dbReference type="GeneID" id="27337969"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10886"/>
    <dbReference type="HOGENOM" id="CLU_061239_0_0_1"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238715" description="Cupin type-1 domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="7">
        <location>
            <begin position="59"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="245" mass="26267" checksum="782E8906BEFCAEC5" modified="2015-04-29" version="1">MMFMSALIGLTPLIGSLVGKPEVVVAVDTTSDPDLVAKLKSAATMLDRLDMLSDEQLVYNFSSNPKYSWHPGSVSNANAATWPILSTVGVTVAQLNLGPCAMLAPHHHRANNLVVAVSGTTNTYMYQENGARMVEQTLTPGMMTIFPRASVHTMYNTGCENNQLYSFLDDADASTTNLGQAFFMMPKDIGMTVMPFIELSNGNWTATGQAMPQVGTGSQAGFESCLEKCGLSTSSYATNNRVVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZG1</accession>
    <name>A0A0D2AZG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232289.1">
        <property type="nucleotide sequence ID" value="XM_016383666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZG1"/>
    <dbReference type="STRING" id="91928.A0A0D2AZG1"/>
    <dbReference type="GeneID" id="27336430"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09347"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29570" checksum="0724BA9F5E31BF4E" modified="2015-04-29" version="1">MDEAAFDTSLGFEGSHVLVTGSSGAIGSVVVRAFLSAGAFVTAFDITETRNGVAHERLHFQKVDITDELGLEQAMEEARKKFGVISTCIAVAGLDLSYLPHVSLVDMPLADWKRIMNVNVDGTFLTCRAWLRALREHATPETKNISAVIFGSEAGRFGVADCAPYATSKAAIQYGLVKSLARDAVNINSKCRINAVAPGPVDTAQFRKECEESENLLWREAEATVALRRSVAIEAVARACLFLASDNYAGNVTGQLLPVDCGKSGALFWLPGGKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZK1</accession>
    <name>A0A0D2AZK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09418</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232359.1">
        <property type="nucleotide sequence ID" value="XM_016383736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZK1"/>
    <dbReference type="STRING" id="91928.A0A0D2AZK1"/>
    <dbReference type="GeneID" id="27336501"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09418"/>
    <dbReference type="HOGENOM" id="CLU_064330_0_2_1"/>
    <dbReference type="OrthoDB" id="4120871at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF71">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="367" mass="40996" checksum="13BF7C76B1D9C864" modified="2015-04-29" version="1">MDRSQDNARELWDWEKNQIRVSTPDPEELKEWQRNLPFKVEDVFDFNSGLREGDVAEPRPPPPPKCDQLDEIEKAASEGDLSTIQRLFDQLRGTSAGDYWIPRQTSSLFRAVRNRHTAVVEYLLSQGSSPTVELAKIAAEHNDTAVLEWFLKHGWDINEQLGWCDPPVLGSVVENAYLVTWLLSHGADPNARCVLDITPLSYAVHSAPFDVIKTLFAHGGSIHNGQLLHFAAGRKLPARLDVVTYLVDQGAPINEVMYHHDQPSTDLQSGAGLGTPVHRAAADGHLDVVRYLVEKGANLTILDSRGKSVLHRAEFYKRQEVVDFLRHILAESSNPPASTHSMGEPVTSRQANTGKLHLHPREKASRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1X5</accession>
    <name>A0A0D2B1X5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_09878</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232816.1">
        <property type="nucleotide sequence ID" value="XM_016384193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1X5"/>
    <dbReference type="GeneID" id="27336961"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09878"/>
    <dbReference type="HOGENOM" id="CLU_000445_33_4_1"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="29"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="455"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW12600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="495" mass="53342" checksum="08A58D1349F96B58" modified="2015-04-29" version="1">MPGRPNIPVRRWDADTLVAPDWLNNGDNAWQLTAATLVGLQSVPGLMVMYAGLVKKKWAINSAFMVLYAFAAVLICWVVWAYKASFGKKMLPFVGVPGPAVEMNYELKQAYLPAAGLSAAYPMSTMVYFQFVFAAITLVLIAGAGLARMNFLAWMVFVPLWLTLSYTVGAFSIWGGGFLYTMGVLDYSGGYVIHVSSGTAGFVMAYWVGPRHPRDRTDFHPNNVLLALVGVGLLWLGWNGFNGGDPYTASPDAGAAVLNTNVCTAMSMLSWTLMDLVFFKKPAVIGAVQGIITGLVAITPAAGFVGGWGAIIIGLCSGIIPWLSMNILGKQKWFLEFSDDVVGDFHTHLVGGVLGGFLTGLFATSEGTAAFALAPNGGAIDGYGRQVWVQIVGFLFVIGWNIFWTSAICLFIKYVLRIPLRYSEEQLLIGDGEVHGELPYAFFHDGRHDYDAKYGQPDPERAAGILEGMEASREGTSEEGSSGQAAIASKADKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2B5</accession>
    <name>A0A0D2B2B5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_08190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233219.1">
        <property type="nucleotide sequence ID" value="XM_016382516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2B5"/>
    <dbReference type="STRING" id="91928.A0A0D2B2B5"/>
    <dbReference type="GeneID" id="27335273"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08190"/>
    <dbReference type="HOGENOM" id="CLU_028981_0_1_1"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="255"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW13003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="505" mass="57094" checksum="69BBE071F0CA51A7" modified="2015-04-29" version="1">MSDDDDFMQDSDAEQYDFEYEDDDDLSGSGDVDIENKYYNAKQLKADAPEEAVTEFLGVPDLEEEKGDWGFKGLKQAIKLEFALGRYEDAIKHYKQLLTYVKSAVTRNYSEKSINNMLDYIEKVASGTDQSAYRCMEEFYSLTLDTFQATNNERLALKTNVKLAKLYLDKKDYASLTNKVREIHKACQREDGTDDPGKGTYSLEAYALEIQMYAEMKNNKRLKSLYQKALTVRSAVPHPKVQGIIRECGGKMHMSEENWKEAQSDFFESFKNYDEAGSMQRIQVLKYLVLTTMLMQSDINPFDSQETKPYKNDPRISAMTDLVDAYQRDDIHRYESILKENQDLLADPFIAENIDEVSRNMRSKAVLKLIAPYTRFTLQFISKHIKIPVSEVQDILGVLIVDKRLRAKINQANGTVEVMTSTEDTVHLDKLSDWTSAVDHLWSSLLNEGEGFRSEEAHGSGSFGGLMAYPMGMESGNAIPSRGAGHRGRGARGGRGGGKALVPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4C3</accession>
    <name>A0A0D2B4C3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_08688</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233716.1">
        <property type="nucleotide sequence ID" value="XM_016383013.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2B4C3"/>
    <dbReference type="GeneID" id="27335771"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08688"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001010">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
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    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="622"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="797"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1212"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1241"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1282"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1320"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1347"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1472"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="186"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="871"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="479"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="830"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW13500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1498" mass="168037" checksum="F4163EA40716F098" modified="2015-04-29" version="1">MADAISRVLSLNKPAQQHGFSANDHVQENGPASAWTSDAHMASEMRPVDREKRPEKSRTSTDSYGLQRTASGVDVERAQKEFAELNRELSSISRRMSRSQSRPSMAKGKDLEKAVSSSDYTSDQGFDLEATLRGNREAEGAAGIKSKYIGVVWDNLSVRGIGGVKTFVKVFPDAFVDFFNVPGTIMSILGYGKKGREFNILKDFRGVAKPGEMVLVLGRPGSGCTTFLKVIANQRFGYTGIDGEVLYGPFNSSTFAKLYRGEAVYNQEDDIHHPTLTVGQTLGFALDTKTPGKRPLGMSKAEFKDRVIHLLLKMFNIEHTINTIVGNQFMRGVSGGERKRVSIAEMMVTGATVCAWDNSTRGLDASTALDYAKSLRIMTNIYKTTTFVSLYQASENIYKQFDKVMVIDQGRQVFFGPANEARGYFEGLGFLEKPRQTTPDYLTGCTDEFEREYKPGRSSEDVPSTPDALVSAFNESVYAEKLSKEMTAYRESIREEKQIYDDFEAAHREAKRKHTPKNSVYSVPFYMQIWALMQRQFLIKWQDKFSLVVSWITSIVIAIVVGTVWLDQPKTSAGAFTRGGVLFIALLFNAFQAFSELASTMLGRPIVNKHRAYTFHRPGALWLAQILVDLCFASVQIFVFSVIVYFMTGLVRTPGAFFTFVLIILSGYLSMTLLFRTIGCLCPDFDYAIKFAAVTITLFVITSGYIIQYQSQQVWLRWIFYINALGLGFAAMMMNEFERLTMRCTAESLIPSGPDYNNIDHQVCTLPGSVAGSNEVSGTAYVKTGFQYDPKDLWRNWGIIVVLCAFFLFTNVVLGETVKYGAGGRTVTFFTKENKERKELNQKLQERKKRRQTKQDANDSSELNITSKAILTWENLTYDVPTPSGQLRLLRDVFGYVRPGQLTALMGASGAGKTTLLDVLAARKNIGVIGGDILVDGQKPGISFQRGTSYAEQLDVHESTQTVREALRFSADLRQPYEVPREQKYAYVEEILCLLELENLADAIIGSPESGLSVEERKRVTIGVELAAKPQLLLFLDEPTSGLDSQSAFNIVRFLRKLAAAGQAILCTIHQPNSALFENFDRLLLLQRGGETVYFGDIGKDAHVLLEYFHKYGADCPPDANPAEWMLDAIGAGIAPRIGDKDWGEIWRESEELATTKSEIIEMKARRQREAASEDRLDEKEYASPLWHQIKVVSWRTHLAFWRAPNYGFTRLFNHVAIAILSGLAFLQLDDSRSSLQYRVFVIFQVTVIPALILAQVEPMYDFSRLIFYRESAAKAYKQFPFAFAMVCAEMPYSILCAVFFFIPIYYLPGFNTSSSRAGYQFFIVLVTELFSVTAGQMIAALTPSSFISSLINPFVVIIFALFCGVTIPKPQIPGFWRAWLYQLDPFTRLVSGMVTTELHGLPVVCKPHELNSFPAPPGQDCGSYMKDFFDAGGAGYLVSNVTDVCQYCAYKVGDQFYEPLQLNFDHRWRDFGIYAAFIGSNLILLFLGSRYLNFNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4G1</accession>
    <name>A0A0D2B4G1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233771.1">
        <property type="nucleotide sequence ID" value="XM_016383068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4G1"/>
    <dbReference type="STRING" id="91928.A0A0D2B4G1"/>
    <dbReference type="GeneID" id="27335826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08743"/>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="101"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="366" mass="40744" checksum="ABCC3FE29A353ADC" modified="2015-04-29" version="1">MPRTPPPTTVPEILATSEIDPSFAKALETSPQSPALDCTITSLKQSSIARLPSIQQSLVDTRPVDVSETTHFIKLRDDFPARIILCHLTSAITDTTPRPLILLFHGGGHCVGYPELELPLARQLAQTHSAIVVSASYRLAPEFPFPFSICDAWETLEFVASEARKANSAVFPRCTDPRVGFLVGGSSAGASLAASLAHLARDHSLRPKLTGHFLFAGTYISDQHVPAKYQERYLSWTQNQDAPILSKAMIRLLQDACKPDFDSKLYMSFDQHHPYDAGTGSVRHGHMGLPPVYFQVCGLDPLRDDSLIYERVLRLECEVPTRLDLYPGFAHCWWTVYPDLEMSRERMKDAVEGVGWLLGTETRDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4N3</accession>
    <name>A0A0D2B4N3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233871.1">
        <property type="nucleotide sequence ID" value="XM_016383168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4N3"/>
    <dbReference type="STRING" id="91928.A0A0D2B4N3"/>
    <dbReference type="GeneID" id="27335929"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08846"/>
    <dbReference type="HOGENOM" id="CLU_009665_6_3_1"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="334"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="481" mass="51812" checksum="B813F4DD8C6D7442" modified="2015-04-29" version="1">MGPAVSGRSSMLKESPIAIVGGGLAGLTLSIGLSHNNIPHKIYESALAFSEIGAGIALGPNSVKALELIDSAIGEGFKKCVTYNEGVDADDNGNGTGPRSSEWMDIRIGMKDSFNTLITTVSHKGSKAPGRACFHRAKFLDELIKLIPADTAQFGKSLTAIKGDEGREGNLILHFADGTTTSASAVIACDGIKSRVRQSYILADDPDQPAAHPQFANEYAYRGLYTREQFVSLTQGQLTPGKGTLFCGNDGYIVMYPVEKGRFMNMVAVKRVSPSSGVGGQPFMAPKAGDTNWVQPVDKATMLGDFADWGESIQALLSQIQRPERWALFDHLPAPTYVKGKVVILGDAAHASTPHQGQGAGMAFEDSLILSGVLSKVLGPDPEIPTETRASDSSIDAKIEACFRAYDTVRRPRTQEVCRTSREMGEMIEFTLPGIGRDLTKMKSNLDKRMDWIWDLDLQAEVQRAVDIAEGILRGTEAESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B654</accession>
    <name>A0A0D2B654_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234396.1">
        <property type="nucleotide sequence ID" value="XM_016381294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B654"/>
    <dbReference type="STRING" id="91928.A0A0D2B654"/>
    <dbReference type="GeneID" id="27334044"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06961"/>
    <dbReference type="HOGENOM" id="CLU_044860_1_0_1"/>
    <dbReference type="OrthoDB" id="3485856at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="313" mass="35157" checksum="AA2B28081085B75F" modified="2015-04-29" version="1">MDSQQGSTLRQSHAEICPADHTDLSGDSSNSLLAHGERCGTVDQPSFPNIAASGDAEQQYQFELQEVARYLRSSPYNDQRPEFFLPAEQFQQFEEELERRRGFAGARPKYDYSYATGTLTLRMPSHMHEALVADLNQSLIGFLLEARKNKETPVSSFAKSIFPMASADVRYPSKDGTDDVLRQPDFEFRTVEHPEYPVLIAQEYIEQTEGHIRTVIAIDLNYPKGKGAQLLVWRAKFGEDGKFEGIACDSMEIRSKDGAKNPNSQARLVISLQDFTFGQGKDEDVGLQSVTVTLLADDLYSVLERMEQLLEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6X0</accession>
    <name>A0A0D2B6X0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234884.1">
        <property type="nucleotide sequence ID" value="XM_016381782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6X0"/>
    <dbReference type="STRING" id="91928.A0A0D2B6X0"/>
    <dbReference type="GeneID" id="27334535"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07452"/>
    <dbReference type="HOGENOM" id="CLU_003938_0_0_1"/>
    <dbReference type="OrthoDB" id="5579281at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029217">
        <property type="entry name" value="Spo7_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15407">
        <property type="entry name" value="Spo7_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01316">
        <property type="entry name" value="Spo7_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="593"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1067" mass="121265" checksum="086A2D01A19E65C5" modified="2015-04-29" version="1">MPAGSLTTTQDLDGLDPESYTARRLKHASPEHLHLTSRKFFIGPIPEGWLNSNRKSWYKRRLELSTYSSKRASFHASADTGPHNRTLTGLDGPSTAARISFSFPQPEDVHDEASSAGEEAGTEIPEEEEVLETANLEPVATNEVPIGPDNEPQTQNNIASSKAIPVPIDRGLDGTRDQSGHKSATSPGPTSFSTAKENMSAISDRDPSLIDERRSRHDTDQEETDGQGSLRISSVGTSSRTPLIQPQTGIPGSQSLRQHEPSPLKDDISYQLKRSTTGVRFKVAEGVQQGRRRIESKAERAIDRVADHRLRRNTLKEGTIVKMERMLVRCDSTMQPLPEDFDENESQKIEMRLLEKWREYMVVTRKSKKQDADDFRLQLYKTRVIPEIDTESTKKKPAHEIRLDPKTTRINLYSSLDKTVVIWHAYKKGTRIFVMRPSSTAHSVEWYTFLRDALGWRRPNVLHINVPDLDVTLKLERPFEGLEKAGADATDEETALSQTVEAEKAVAGTIIAKCLDMLKRDPEWSSVLKVWSESAHMGLAWKRYDRLEWVSGANEQKMYGSMAMQRSHDLELRPKQHYPTCTHGRKGKLHEEPSPIEGFLVRLTSQKGVHQRFGKAFFKRLYFSTHDQFLVFNRPAKATPPHPPRLATIGGQNIPSSQEIIDKTPLMFEVEPYKLKDAAVSWLASRDRLSIESHDRDALEEARRNVANLLESDGFVNLCYVKKVRTIKWGASPADDTLDIGSDSDVDFHQEVSDTRAEDGTTKQIDDDRVFEILLDNGLVIRLQAYSKQTRDEWISRLKKLVKYWKLRVAAEMDTYKSIRRANLEELNIDEELEAIIGQFAKKWEVSRSQTSPELYNMCGFSVCRSITMAGPLYLKTKRRAAFHRSQVILTGGKLLIYQASLRKRTGQEIRHIHQEKQQVVDLRDCYVYSGLIVEDDLLYQNKTFDANHPGIATLPRVYLEDGWTSADVDVMTCFVVWQNRRKGWFRTAAVAQDNKSSSDGQGDGGRTRATLRRVGQLGVPGRGMVFKCRSRAERDRWVLSVSCEIERLVEQEVEELGDEGEFRFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9K2</accession>
    <name>A0A0D2B9K2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_05681</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235849.1">
        <property type="nucleotide sequence ID" value="XM_016380022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9K2"/>
    <dbReference type="STRING" id="91928.A0A0D2B9K2"/>
    <dbReference type="GeneID" id="27332764"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05681"/>
    <dbReference type="HOGENOM" id="CLU_075474_0_0_1"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="131"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW15633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="229" mass="25974" checksum="F5CECD6D4F1EB3BB" modified="2015-04-29" version="1">MSNPLDTDAGSELFSTYEAELKLVEADITQKLDQIPELSGEQRKAAIRGAERAIEEAKELLDQMTLEKSNIPTSARSKVNTRFRNHQSDVDSLTRKLKSLADSDRKQLFGDRYTDDPEAGPRDLQLEQRQQLLSGTERLGRSSNRLRESQRIALETEQIGASTLADLHQQRNVIEHTHQNLLQSEGYVDRSVKTLRGMARRMATNRMITIAIITILVLLIIGVIYSKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAQ3</accession>
    <name>A0A0D2BAQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235886.1">
        <property type="nucleotide sequence ID" value="XM_016380059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAQ3"/>
    <dbReference type="STRING" id="91928.A0A0D2BAQ3"/>
    <dbReference type="GeneID" id="27332802"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05719"/>
    <dbReference type="HOGENOM" id="CLU_018404_0_0_1"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW15670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="695" mass="78175" checksum="20981A0150EB44C6" modified="2015-04-29" version="1">MRPPPDATSCSRRVLSCARCRKRKVKCDRRLPVCSRCEAAKATCTGVSTVDSEAQVPRSLVQFLESQIAQWEIELQAQKDNGLVTGYDNLESQGDNSENLPAREEDGFHRENGDPLAILSQAAETFEETRVVETTGDLESSIIRSSEFRSMVGATMPTDPALTDLVSRVRMGLTPSAVLPIITVQSPEPRRVPVPVSSEEDWLDVATLATLPEHVVQTLVRKYIRHVFPLSPVISQEEVNESLETVLVTMRELRNKSTSKRVRPSFPFLAIYLVLAISSTLGCAKTQHESRCLAFSEVLFHEGISHLTTSLQYPNDLASLQATLLILQYAEINPKCANIWIMNGAAMRCCLELGLHREPVRPITLDRKTIELRRRLFWAAYCMDRTISPALQRPLYIPDALINARLPESPRNNAEEREMSKPAVLDWVSYCRIQSEVSEVHFQGKILDCDWESWVIEAENKLMRWYRDNLSSDEVVEFAYAQGLVRIHRPSPRRSMPSTESLVTAFEAASRAARHNREPILNGFLRKPWLAAHNTAETAMVAVFCLRHAFDEISQRYSASEIFDKTKVFTSNLLALAAHGWPEISQFAATFERLLAPLINGIMMKTSTALLMYPSSLEAELDQFLLPGPSRKETFFGNGFPNIMELSGFEGGLGEDMNWDEAFLETLAATTDPYNWEDVALGHDEVMNDFMGQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BB34</accession>
    <name>A0A0D2BB34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236434.1">
        <property type="nucleotide sequence ID" value="XM_016380607.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BB34"/>
    <dbReference type="GeneID" id="27333352"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06269"/>
    <dbReference type="HOGENOM" id="CLU_000126_1_0_1"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056779">
        <property type="entry name" value="Csf1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25038">
        <property type="entry name" value="Csf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="153"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 C-terminal region" evidence="4">
        <location>
            <begin position="2507"/>
            <end position="3237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3238" mass="362310" checksum="C31186B9ABC39141" modified="2015-04-29" version="1">MSDLDNLVGQPINRDTSFNWYATSPMTWFIEIATCACLALFFLFYFNRLIATLVSYGLRAWTWHKYRVWIDIQALQLSFLAGRIFFKGIRYHGENETILIQNGYVTWRYWQRTARQVDLTGSDHGDDDLLKEKEACDSDDSEKSEPLADQELGRSQKADTADARIAINVTGLEWFVYNRTPVYEAIVNDTTASGSYDLDEKCHVNGHWQGAFHAKIRRRKHAKGRQSEVGLDSDSSTGPPTEKTDGIVTRDELNVPLSHINTDITVDTDADLPATQVSSFYPFLLRFLPVKVEVSKGAITLGNATTRAIVVSTFTTARGHIDAAAAGPFDIFRQVFDFSIEQPKVEMRPNPDFRASQLTTAERIISAAESEAGRRRWWQLDLGIRRRLARAMRRVRHLLPGLRSSRGSLRTNTSIDNEKNKHYIYEAFPEQDRSWHGLGRYMDEDERDDHEGWAHVDYARFSQILESPNVHLNFYWDIPGQVTAEHVASSREAHFQDINLSTPPAYGLDLTVQGGTVNYGPWADRLRLELQSAFFPNPYRSPVPSSALKVGNTRQNTVMTIRVDLEDEVSLRVPTRERSKDWQWRGRAHAVREAAAIRKQRERRHFRFRRPQKSKLGPELRPFGWLTVSAGKDSTVRYDMDMIPNAQGYRNQLRLDLKDTKATSSVNHALLWRCRSQKVSCDLSNPLVWNSLHTWVFNIENNAMEMFLLRDHMFLLTDIISDFTDGQKPDYMTFVPYLYQLHLQFPDLKLYLNANDYNIIDNPCDLDENSFLVLGFQLLDGHVDIPMQYFSPRQSSVKFLAEGHNAFLDLSTPVWHTLHTLAEDKTMATLKRLDLDGSYNYYPQISPKLTDSLFMTITGSSPKFYLHGYLIRYFMNVKENYFGEDLHFRTLEEYQDILAGNAVRTPRPATKKENDLDVILTVRADNSSILLPANIYSRRENVRADVLLVEADMRFTNYYMDLQVNSSPLEASLETIRKVESGPSEDITNCQLFIDGAHIYGHRLFGAPPTEPAYVCNWDIDVGETTGEVDAKFVQVLINAISSFIYTLDDYDNALPKLFTTKVHDVTFLRAAVAGLRIWLVGGGAAFLLESDGADISLSDWANANFAQRVQANIPRVLLAAVDHASAIRHHGRESKAVETIACFETALRIGSLDKSDNLSQTRALQQQHVKYHDQRSHRAQWILGAQRNYPPNHKIPEWARDPPATPLPMMPEPVVETEAPDISAINDQVHRTQAMNRKPSFLSTASSLHNYPAGSTTLANRSGRDPKPSLSQTLDPQHPSTMLQGDSQEQIAESVKNSPFREDVHPALPFAGPWLPPYFTLRDVKPDKKNMPKVSRSELTKAASLMATFNNEDLPKSDEFEGVPHNGVVLLIDKGLTGFCSPALFLCIGGLIQELNNGHAINHLDKIQVTLMEKILESQSHDDKGHVVDFAVHVPFAHVRLLNSLQNAAQATSCSDDQYDVKLLGTQAMYRSLHPHLDFRQSGTSVPSQSAYASIEKLTVSARDDLFADRPATQAEVSLSNFGFWLYLKEQIDFKCQLSNFGVFLWAEQLTSMAGLIQRTVSMIDRIAEAFIGLDQSRMSRHLIFHLTQAGSSISEPIFLTKPSYVLRSADKHVRLTDSWKIMSRLRYIFATLEKEKGPKSMSSCDCQDLELKGPALQRVLTSFEQWRGWDYRRDTVPIMSTLFENQRPETALKHPGGLAAQGEIIIGKIEVILDPGPRQSDFTVLGLDFNVVVSPVTALPGLEERSEKVILQAYLADASLHLNWALVELARQIIDLGSPLAVLPTRVSSSSKDGPDRSHTRRQFTVVVGSDVAAIYLTTLNLKLKWASEGFRSAVSFDSGGELPSVHSWTIAANSALTKFRAHSHTLMTWKLRAPKMYGSVWPRQSTDSQESILVVQVCAASRRYRFQLKEDVSKLLGVIDRVVLDEAAAVYDLLEMTSKTSNSELKKTSRPLAASMELRTALFLDDYRLTFAIVPTLRYTIAGHVARTSILPRKHGSLEFNFDIKEHEHLFEGPDDDSKSKSSILKMPPINGRVSIAQTSSIMSIGARVTIEQINLETSGIRACFEALNQPGVIQQLLNTRRAVQDVQNSVKHVTDGRSKLQRAASTETTLLLRYAVHGTLAGIKVHMSAPTVRENQTYRADMELKLEATTLFVHNHTNHPDTIHEQPQFIMNSQGVGIGIYRATDHAKSNVGKCTVGIKASGKTEPAGKIGKVHVYRAWSDGIAIELYEDTATLAVDIAGFIHDRIKSIQLAESPESIQRLRKMTTAGITDRLKPKEQIEAALEAVSTNESLSSTLYDSTYAVNLDNIQVRWNLTRSSFLSPTRELQDLVFSIRKVDLQTRQEGTARLSILDTQLQIVPQSQSSQPTLRTANSALLPEVVFGSAYLSTKQDRRFAFQAKGKAVDIRLATDFVVPAHALQKSLAHASKELRNSKTLYETSLQTAQSGKIETSSGKHLASLLVDADFAGAVVHISPWAEVRHRDSAFSFLKGGKRSRAGRYGQAVQGENASSARLQSPGVALKVEYKDNGSGDPYLSTEVKVAASTNTLYPTVVPLILEISSSIKEIMDESNNDGSGTKPGDISTRLSEETINNANPTAILGRCKLNAGLYIQRQEFSLSCQPIARVAATTRFADIFIRINTVSTPDQGRFFAILTTFNKLETSVQHVYSRESTANFEVDSIVLSLMNSKHVSATTGISAVLNVSPMKTDINAKQLQDFLLFREIWYPAELRGSSKPSASVATAQDQHVYAMQRYQEISARGTLPWHAIVSMQEIKLAVDFGQGLGKSVFTISKLWASSKKNNDSEQNLCIGFDRVGIDSSGKMSGFVELDNMRLRTSIRWPEDSSRRVRAPLVQASISFEHFRVKAAFEYQPFAVADISFFEFLMYNVRQGQGFDSDRLVGIVDGGKVQVFVTTSTAAQAFALVEAFERLIQEKQEAYETSLQDLDKFLRRRSNFPSSSWTAPTPDPQLKGHPPPKRTFALHTDVVVGLREVDIGCFPNTFFDDRLLKAEATEVQARFAVATTDGKTHSGLGMTLGELRVALSSVNRTTTKALSEVSVPDVIDRATSSRGGTIVKVPRLVSSMETWQVPDSNTIEYIFRSTFEGKVDVGWNYARISFIRDMWQTHSRALAQRLGKPLPPSAIKVTAEPQGDGEGGQEKITAVVNVPQSKFTYVALEPPIIDTPQLRDMGEATPPLEWIGLHRDRLPEATHSIAIVSLSEIAREVEDAYARILGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBW4</accession>
    <name>A0A0D2BBW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236694.1">
        <property type="nucleotide sequence ID" value="XM_016380867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBW4"/>
    <dbReference type="STRING" id="91928.A0A0D2BBW4"/>
    <dbReference type="GeneID" id="27333615"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06532"/>
    <dbReference type="HOGENOM" id="CLU_084522_3_0_1"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014500">
        <property type="entry name" value="UCP019307_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019307">
        <property type="entry name" value="UCP019307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="175" mass="19005" checksum="615BA8DE3CD929D1" modified="2015-04-29" version="1">MAITPLNALRVSSHQIPAYKGIPNTSIQGKPLMIYHAVFPSASAPQIKAHLRAVGVVSPQWEYSMFAETHFHSTTHEVLSIASGSAKCCFGGEKNEGRLEPVLEKGDVVIVPAGVGHRLLEDYGGFQMVGSYPTGKSWDMCYGREGEEGKVRAIKDLGWFEKDPIYGDDGPSLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDY3</accession>
    <name>A0A0D2BDY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04364</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237389.1">
        <property type="nucleotide sequence ID" value="XM_016378712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDY3"/>
    <dbReference type="STRING" id="91928.A0A0D2BDY3"/>
    <dbReference type="MEROPS" id="M03.009"/>
    <dbReference type="GeneID" id="27331447"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04364"/>
    <dbReference type="HOGENOM" id="CLU_001805_1_1_1"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.40:FF:000001">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="11">
        <location>
            <begin position="217"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="723" mass="82372" checksum="5EFD20194E9258F0" modified="2015-04-29" version="1">MASPKFRKPPQAPPSFTATPESVVKDTKEMLAQSKKVTDDIVAQIAEKDATFQNVLLPMAHDENLQTLKAHILGFYQSVSTDQALRDASTEAEKLMDDYSIEAAMREDVFKLVDAALKKADKLDPESQRLLQKEHKGFVRNGLNIPAGPKRDRFKEIKKRLSQLGIAFSKNLNEEKGGLWFTAEELDGVPEDVLSILKKEGDKYWLTFKYPDLFPTLKYATNSETRKKVFVANENKCNQNVPLFQEAILLRDEAARLLGYPNHAAFRIEDKMAKTPKTVDDFLGDLRQRLSQGGLDEIETLKKMKKADLESRGEQFDGRYYLWDHRFYDRMMEEKDYQLDQQLISEYFPLQTTIRGMLEIFEQLFGLVFVEVVGKDRDSISPSGKGDDIVWHEEVQVFSVWDDEGEGGGFVGYLYLDLFPRNGKYGHAANFNLQPGFLHTNGTRRYPATALVCNFSKPTAKKPSLLKHEEVTTLFHELGHGIHDLVSRTTYSRFHGTNTVRDFVEAPSQMLENWCWTPSQLRALSRHYSTLSPEYYDSWKEAAGSNSARPEERIPDDLIQKLIKTKNLNGALFNLRQLHFGIFDMTIHEPRDHASIESMDISETYNALRKDISKIDGPEVLGEGNKWGNGQATFGHLMGGYDAGYYGYLSSLVYSTDMFYSVFRKDPMDPKEGRRYRHTVLEKGGSQDEMTTLIEFLGREPKTDPFYEELGLTKGTQSGAGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEZ2</accession>
    <name>A0A0D2BEZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237416.1">
        <property type="nucleotide sequence ID" value="XM_016378739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEZ2"/>
    <dbReference type="GeneID" id="27331474"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04391"/>
    <dbReference type="HOGENOM" id="CLU_038504_0_0_1"/>
    <dbReference type="OrthoDB" id="5593235at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="406" mass="47366" checksum="C08EBB30E1B9304C" modified="2015-04-29" version="1">MAISRLYSDGKYSRRRWIVGILAFLTFAVLVISFTHYRRNYYGEMSFPTSHIETEFTKDLRVKEFIKPEGVKVVGLVFFGRKNRVEILRCFLERNLVDNGGWLDEIHWVKNTDKQDDLAYLDEILASSPRYKKIELEGVGFVGYGYAWSHLEPGHLYIKIDDDVVWLADDTIPRIVTMKIAHPEYLLVSANVINSPLMGWVHYHMGAMHPYLPEFDVYDPPLLDAVRSTDRKPWHYSKYPYWNGPDDYFFDIHQDPPYNGHRWLRLQNDTAIHRTPVSEIEYKTWGTGLKSWAIAAQEHYSFLENLANDQLDRYKMGKAWLTDYKRLSINFIAVWADDVLNNLPMDTVDEEWLTINLPKKLGRSVAVETDALAVHFTFGTQGKVGQTDLLPRYHDYALENACARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF99</accession>
    <name>A0A0D2BF99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_04863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237884.1">
        <property type="nucleotide sequence ID" value="XM_016379207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BF99"/>
    <dbReference type="STRING" id="91928.A0A0D2BF99"/>
    <dbReference type="GeneID" id="27331946"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04863"/>
    <dbReference type="HOGENOM" id="CLU_025144_1_1_1"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW17668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="449" mass="50112" checksum="23DC42C3A8A41DC1" modified="2015-04-29" version="1">MRTTLRLAASAVHPLRPSLSLPTLRCIKPIHHTNTLRTITGIHHGPTTPSRATATRTTKSQCFSTCQLSGLRRRIPRDQDGSSIYEFATPSPTKPNLTSRDTKLTCAYFDKDGTLLSEHKQLTKSKIAEQFELRHRDLRDIDLRSESVTRILIRPATILLQFFDLCMIIQADEALLVNLHDSQNGNEGASSGSSSSSSTTAMYSDFERRMSAKETADLPELPYELRAVEAALVAVLSIIREELVQAKQDAEESARKLNLESGFAAVGLDLLFEHSRQLGKIEQKARLVRDTIRGVLDTDEDLAAMYLSDRKAGRVHEIYDHQEAEYMLEAYHTAADALVESASAAMDVMRKKENTFRSSLDVQRNQIMFLEAKVAIHTLGVAAGTLIAGLFGMNLINYFEDAPYAFPIMTGACVVISSLFSMKGMRSIWRIQKLKGIQGQMIPSRHRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFU4</accession>
    <name>A0A0D2BFU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_11206</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230460.1">
        <property type="nucleotide sequence ID" value="XM_016385516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFU4"/>
    <dbReference type="STRING" id="91928.A0A0D2BFU4"/>
    <dbReference type="GeneID" id="27338289"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11206"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_20_1"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW10244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="396" mass="45093" checksum="8808D2059838AAC2" modified="2015-04-29" version="1">MSQNRPGGVFSGLRMGEVVREKVQDGLTGETREMQYTQCKIVGNGSFGVVFQTKLTPSGEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVELKAFYYSNGERKDEVYLNLVLEYVPETVYRASRYFNKMKTTMPILEVKLYIYQLFRSLAYIHSQGICHRDIKPQNLLLDPSTGVLKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTTKIADVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTRDQIRTMNPNYMEHKFPQIKPHPFNKVFRKASPDAIELISALLEYTPTQRLSAIDAMVQPFFDELRDPNTRLPDSRHAGGASRELPPLFDFSRHELSIAPHLNNKLVPAHARSLLASRGLDVDNFTPLTKDEMMARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BH63</accession>
    <name>A0A0D2BH63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_02621</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238549.1">
        <property type="nucleotide sequence ID" value="XM_016376979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BH63"/>
    <dbReference type="STRING" id="91928.A0A0D2BH63"/>
    <dbReference type="GeneID" id="27329704"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02621"/>
    <dbReference type="HOGENOM" id="CLU_032441_5_0_1"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW18333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="461" mass="50740" checksum="DF28A46E8AF3F9BF" modified="2015-04-29" version="1">MGRSTEFVTGHHDRVTVLHTNFNGTRILTASIDHRIKVWQRDPKTGERTLIDTFTAHDADIRDAKFLHPTLGSHIASIGNDLKFHLWSEDVSQAPNSGRRFRRTSTVPSTPRVPFVSMDLKTIDNIYTTLALIDRQGLLSIYEPTSPDDLKDWTLVDTFNVCGSSPPARGDETSFKVRFDPNPTPLAYMNSLSDDRSQLSLVVSVLNEFKIYRSVVPSGDSSSISGANDGASHRVMFFEAARSRRHPSLIRDVAWAPFSVRGTDRIVTACKDGTVRIFELSVTQAPDRSLTAAATTTNTATDVAAQGPVQNASTRRQQQQLLQQQQQQQQQQQQQQQQQQYHQSSLTTGLTGRNPGASTSALAPSSASIASWAARTGHAFPFQTNVQSSTALDDAHTDAWSVSFDGQGQVLMSSGSDGITKFWRKSVQDGRWLVFAGQEVLETDADTEGDDTDDGHDDDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHH3</accession>
    <name>A0A0D2BHH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_02327</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238256.1">
        <property type="nucleotide sequence ID" value="XM_016376686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHH3"/>
    <dbReference type="STRING" id="91928.A0A0D2BHH3"/>
    <dbReference type="GeneID" id="27329410"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02327"/>
    <dbReference type="HOGENOM" id="CLU_009074_2_1_1"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="10">
        <location>
            <begin position="106"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="9">
        <location>
            <begin position="409"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW18040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="750" mass="86392" checksum="68499E81E4D8AC79" modified="2015-04-29" version="1">MARTLRSAQKPIPTNGSIRAANGHANGTPKEHSQHTGGETLDRSRWRLRAEGGRHTWHYLKSEKDVQEWPQTVADKYYLGLPTNLPDLPPASKPSESIDNCLTFYSKLQLPPGHWACEYGGPLFLLPGIVICWYVTGTPIPAEYEVEIRNYLFARQNKDGGWGLHVEGHSSVFGTAMNYTLLRILGASEEDPRLIKARGKLHQLGGAVNGPHWAKFWLSVLGITQWSIVNPVPPELWLLPDWVPFAPWRWWIHMRQVFLPMSYIWSKRYTMPENDLIRSLRQEVFTQPYETIDFGSHRNSIAPEDNYHPKSWLLKLLMSILVWIWIPLLRTKSLIDKAESWVWRLVQYEDHNTDYADLAPVNAPMNTLVCFIYEGPESYSFKRHLYRLEEYLWVNKEGMLANGTNGVQVWDTSFTIQACVEAGLAQSPKWKPMLTKALSYLESEQIRDEVKDREICYRQSRKGAWPFSTKLQGYTVSDCTSEALRVVLLLQNAHGYKPLLDDRRIKDAVDVLLTMQNKHTGGFASYEIQRGSEYMELLNAAEVFGRIMVEYDYPECTTAVVTVLSLFQKYYPEYRTEEIRRIKETACQYIRRAQRDDGSWYGSWGICFTYAAMFALESLSSVGELYSNSARVKKACEFLLSHRMADGAWGESYRASELKVWVDHPDKSQVVQTCWAVIALMYAGYPDKEPIRQALRVVVGRQQSNGEWLQESIEGVFNCSCMITYPNYKFYFPVKALGMYKARWGDDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJP4</accession>
    <name>A0A0D2BJP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carbonic anhydrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239349.1">
        <property type="nucleotide sequence ID" value="XM_016377779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJP4"/>
    <dbReference type="STRING" id="91928.A0A0D2BJP4"/>
    <dbReference type="GeneID" id="27330508"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03425"/>
    <dbReference type="HOGENOM" id="CLU_084253_4_0_1"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="14844" checksum="EF1B9C1B1EBC9A5B" modified="2015-04-29" version="1">MVSKPLAEMLARNLSKFAPTYQAPPGLMQLATKIRASGEGVVVLSCSDPRLNPYQILGLDSSLPATMVRNAGGRAFDAIRTLSVLQTIGRPGTIVVMHHTDCGMSHFHDADVKRALLEINPDAGELIQSMEFGEIKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJR2</accession>
    <name>A0A0D2BJR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP-binding protein ypt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239051.1">
        <property type="nucleotide sequence ID" value="XM_016377481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJR2"/>
    <dbReference type="STRING" id="91928.A0A0D2BJR2"/>
    <dbReference type="GeneID" id="27330207"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03124"/>
    <dbReference type="HOGENOM" id="CLU_041217_6_0_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37650" checksum="FC6B4EE0D9CC8045" modified="2015-04-29" version="1">MARPRRPSASSDMSSIPDQNQELGSMYDYLAKVVLLGPSGTGKSCILHRFVKNEWRVLSSQTIGVEFSSKIVKCGTAPNRRRIKLQLWDTAGTERFRSVSRSYYRGAAGAILVYDVASLASFNALPTFLSDARALASPQLTVILAANKSDLADTSRTQPQPMNGSAATLPGQQQQQQDHTPSASSASSRQSYFPSDSGGTPTGTTRSRADSLLNTSNKWTATTSTEGREVPSELAARWASQVRIPVTMEVSALTGENVEELFSRLARMILTKIELGEIDPDDPASGIQYGDGGGWDGDAGSSARSGAAGDDSTLRKRRKRPAGRNGILTNLGEWEDVFRRPPSRGGGRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMH8</accession>
    <name>A0A0D2BMH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PV08_00365</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 18"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240006.1">
        <property type="nucleotide sequence ID" value="XM_016374730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMH8"/>
    <dbReference type="STRING" id="91928.A0A0D2BMH8"/>
    <dbReference type="GeneID" id="27327448"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00365"/>
    <dbReference type="HOGENOM" id="CLU_029960_0_0_1"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000009">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 18" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="19">
        <location>
            <begin position="8"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="20">
        <location>
            <begin position="217"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="14">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="193"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="348"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="353"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KIW19790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="402" mass="46107" checksum="1898A47AEFA65CD0" modified="2015-04-29" version="1">MPDKILDDISHRRYNLLRGSWILVSPHRTKRPWQGQQESPGVIDLPSYDPQCYLCPRNKRASGDTNPDYQDTFVFVNDYSAVKEEQRDYASPDVQGSLSSLLLKAEPVKGKCYVLTFSARHNITLADMSPAEILQIVKTWTEIYTSHISPNSPLAAIAKPTHLPPSNRHAHVGTPKEQYRWMQIFENKGAAMGCSNPHPHGQIWTTTTLPEEPSLELEQLRKYHREQGGSHMLVDYARLEREKDERVVFQNETFLVVCPWWATWPFETMILPVKHLRSLIDLSETEQMDLAEAIAETTRRYDNLFETSFPYSMGIHQAPLDGTKEEIECSSLHLHFYPPLLRSATVRKFLVGYEMMAEPQRDITPEQATARLRACGGELYRKHLQAQGEKVENPPVEEKAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMR2</accession>
    <name>A0A0D2BMR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016375173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMR2"/>
    <dbReference type="GeneID" id="27327891"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00808"/>
    <dbReference type="HOGENOM" id="CLU_053392_1_0_1"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="419" mass="45908" checksum="6FC6CF232D67D6C8" modified="2015-04-29" version="1">MPKTSSGEKAKFRAPSPPESRPNNDTITDSGSTHTQPRPPSPQDLPPSYDVINPPIPSISITPTSAVSSNDIPSFLARSQNPLDAISRLASVDLTRYCGVSQAKLSASQDTLTTTKPELSTMQYVLMRFLNEQASLPPKPLMRIQGSHTTSTGTTQIDFDLTLNLMSLLDIDHRVSADDTGGSNTTATAATAPSTRLHVEPFESSTPTGSSSPFKRSSRGNQPAMTPLEQWAKKFTDEKTENKSFSLHRQIANFPAAILEGMVRTLLAATRYRGKVTVEFPVQFAKVVVQRESGNWFANMLRLYPTKKYEVVQTVWDVASTGNPGPGPGTGPGDIAGTNSTTTTAAAAAATSSTQKHQQHHQMDRAGLVAQEWWREWQYAIWNAVIKRRTGWVTIEDWIEAKMGVKLPQPSREWGVESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNM0</accession>
    <name>A0A0D2BNM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_10007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232945.1">
        <property type="nucleotide sequence ID" value="XM_016384322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNM0"/>
    <dbReference type="STRING" id="91928.A0A0D2BNM0"/>
    <dbReference type="GeneID" id="27337090"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10007"/>
    <dbReference type="HOGENOM" id="CLU_1896224_0_0_1"/>
    <dbReference type="OrthoDB" id="4369586at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="134" mass="15927" checksum="71347CF29B3721C6" modified="2015-04-29" version="1">MYQGLVNKAIEIDNWLYELGLKKKGYYGKTGGVYYKGKRTNYQFYGDSMDLDVIERGRSSRLKGKFQCKGLSNKKRERRKKENLCYNYRNPRYKANEYGTKPVRLHIIEVGIEEEKADTLIKKELKRLRLESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPM5</accession>
    <name>A0A0D2BPM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233240.1">
        <property type="nucleotide sequence ID" value="XM_016382537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPM5"/>
    <dbReference type="STRING" id="91928.A0A0D2BPM5"/>
    <dbReference type="GeneID" id="27335294"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08211"/>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="370" mass="40513" checksum="9EB6F7E84E3DE8C5" modified="2015-04-29" version="1">MAPMTRRRALLDYTPHDMMTEYYAQRASVAGTLLISEATSVSPRSAAMPHTPGIWTAEHIAAWKAITDAVHARQSYIFVQLWMCGRAARPGAVKRGAEVVSASTVPIGAEYPTPRSLSETEIQECIGEFRQAGINAIRAGFDGVEVHGANGYLVDQFTQSVSNVRGDQWGGSVQNRARFGIAVAKALADAIGPERVGYRVSPWSHHHGMGMEDPIEQFTYLVQNLSALNLAYLHVIESRVQGNADVIGTESIDFLIKAWDNGNPIILAGGYNATTSREAVDKWRPLGKNMAVAFGRSFVSNPDLPLRIQQQLPIAAHRRDMFYEVLNPDGYINYPTIKPESQLATSGADIKQPLVETVQISSDAHNDIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ49</accession>
    <name>A0A0D2BQ49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233470.1">
        <property type="nucleotide sequence ID" value="XM_016382767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ49"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ49"/>
    <dbReference type="GeneID" id="27335524"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08441"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_5_1"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="57"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="500"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="594" mass="65673" checksum="8FE9263F9A84F489" modified="2015-04-29" version="1">MSIPKSRLANLVGHFLPSSSTPSQGLPIDNLVIDNRKVGSPSWYNHHTLSPCFFLPRAAAIEPNAEAIYHRTANNKILRRSYIEFADRARGFAYYIKKKGYKRVGILATNTPAFLEAIFGIGAAGAINVAINYRLKKDDIAYIFDHADVDAILVDAEFVGLLDDYKQKHPTVPVIIDTDTDAIEGQLCGPFDEAVLEGLQYDQEQGAYGWDQLESQAPDEFSVNALAYTSGTTARPKGVEYTHRGCYLGALGNVVESGLSYHDGERCKYLWTLPMFHAMGWTFPWAVTAARGTHYCLRKIDYPEIWRLLRDEGITHYCAAPTVNTLLCADSNAAPLPKPVRVTVAASPPTAHLFEQMTSLNLQPVHVYGMTETYGPITKGYIMPEWHQYPNVKDKYAKMARQGHGFITSLPCRVIKTEVPPGTVVDVEKNGQEIGEIVFIGNICARGYYKDEAATRKLFQDGVLHSGDLAVWHEDGAIQILDRAKDIIISGGENISSVALESLLVTHPDILECGVAAVSDSHWGERPKAFITVKSGSNTTGEDVIQWSRNHPGISKFMVPREVEIVPELPKTSTGKIRKNILRDWAKGAKRGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQP4</accession>
    <name>A0A0D2BQP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233670.1">
        <property type="nucleotide sequence ID" value="XM_016382967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQP4"/>
    <dbReference type="STRING" id="91928.A0A0D2BQP4"/>
    <dbReference type="GeneID" id="27335725"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08642"/>
    <dbReference type="HOGENOM" id="CLU_028540_1_1_1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="594"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="72256" checksum="0697C878F6BC6EE8" modified="2015-04-29" version="1">MSVTVCTSSAPGLATQRRNLAGKRTNSLGWAKADCHTCAEKGRTCDRRRPKCSACLDDGGTCGGYIQALNWERGTVRLGKSKFKAAASVTRRAPSEETSSPQSQSQPQPKLPQPSAFVFVDQTHSSEKPRKKPRKNSKSRISIPTPPDRSARSSISSNWSSVNPTSPSTSWSLTKSTTPLSATYESHEVLLPLSPRLSRPPVEDALAFYHARFSKTTLTWDVPVNPWQAALPQIHDEVPCVLYAAIALAQRQQAHLSHQAEGLGVLSLKAKALSIFATHFNDLSFESAISTTLLLIALDYAESGVSNWAIHLRGALNVLESSGGIRVAESRQNLRSQIAMLLWYDVAAAMLSRCSPIFPRRYLESLMLWQRETEWSMIGLNGLPDGMFLDMYDLAMTAAHPDAISAEVITAFEARITGALVGDEENSLLNAMSQVWKLGLLLYCQRVLVPFVHDNYDVNFGFDFDSSTTKSAFTTIDPDSSSSSSSSSSSSPFRVTASSDDGGPRHLAIEILSIVAELPPDSNFQKQCLLPIILAAVEVPSRDLRYRKVAIDYCVRWKERTGIWIFDSALEFMSGVWSRNDSEVQEVQIFQTRREALNSGPGEDDNDNDNDHDDDDNDDDDYHVRNRNRNTSAGMAVPWTEIYPRGVEYGFLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQX8</accession>
    <name>A0A0D2BQX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233790.1">
        <property type="nucleotide sequence ID" value="XM_016383087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQX8"/>
    <dbReference type="STRING" id="91928.A0A0D2BQX8"/>
    <dbReference type="GeneID" id="27335846"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08763"/>
    <dbReference type="HOGENOM" id="CLU_002220_2_0_1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="565"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="884"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1032"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="884"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1032"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1217" mass="133079" checksum="65DD9B2E225BE536" modified="2015-04-29" version="1">MEPTYFTCDLGQAVLHQHGKEYETVTELVDYKARKEQKLPAVGFFSSSHKSERWAPHILSFEEVQRGSVVVADALSTKLRSGSKQTIALLCPSSPEFLFTWLAIIRWGHAALLIAPQCSPSAIAHLCRSCEVKCLIYDEVYKDLAEKASAESAKSEGLPIDATALPFAEEDVLDIIARTPSRPPKPAEGIQRSDIAYLHHTSGTSTGIPEPIPQSHQGAVGVLPSLDGTEHASFSTTPLYHGGVADLFRAWTSNALIWLFPGKDLPITAANVCRCLDTALCAASKGVPPVKYFSSVPYILQMMSEDEAGLKYLQRMDIVGVGGAALPPEVGDKLVGANVNLISRFGSAECGFLMSSYREFQKDKEWQYLRVRPGQGYLKFEPQEDGLSELVIQAGWPHMAKHNREDGSYATADLFAAHPTIPDAWRYHSRADSQLTLVTGKKFDPAPLEDAIRASLPLVDNVLIFGNGQPHPGALIFRSEDAALLTDDDFIRTIAPVVEKLNRVGQSHARLPRNMLVPMLYDQKGLEKSSKGTILRSRAEERYASNISKAYSAAPADKTSNVSDDDIPRTVRKIVTDIASDRTVIDPEFLNDRTDLFAYGIDSIGCIQIRHGLSRLIPDGSALPLTVVEDQGTISRLSALILRIRRGGEAYDKIDKADTASEEHALMLDLAKRYSTFEDNATSPISSPSSFGSTTTTATTSEQKGLQILLTGPTGSLGSHILHQLLSNHRVSHIHLLVRGSTAQASRERVLKAFSSRLLPIPADFTARTTIWQCALSDNLLGLSQSDYTTLASQVDVILHLAWSVNFLLPLRSFAATHLAGLRNLINFSLSSPRLYPPRLIFCSSVASVSAYHQNQSCSSCPDSTDQDHTDKVHMDIRTNINTHIDTNTNTNTNTTTDADTFHSRSTRPKSAINVPELPVSNTPSASGPTGYARSKWVAEAICAAAHTHTRLNSRISISRVGQLSGATDTGVWSKTEAYPLMLSSSKVTGVLPDLGDWEVLNWLPVDLAARAFVEDALSTLTVGETDTNLITTTTTTTTSSTTAPTSTSTTTPPPPPPPTGPHSQPNEKGDEDGGKITHESLQPPRLPVSVPIPVHHVLNPYTDTGMHNWSNLLACLSRHDNFKVVSVGEWLDALSSLHERPGETSLHPALKLLGFWKGVYGSRHQHSPAQMVDNSETALRFDMDKTYVRMPCLREQQPGLDDEYMVKTWRWIKANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQX9</accession>
    <name>A0A0D2BQX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin-nucleotide-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_01988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241624.1">
        <property type="nucleotide sequence ID" value="XM_016376348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQX9"/>
    <dbReference type="STRING" id="91928.A0A0D2BQX9"/>
    <dbReference type="GeneID" id="27329071"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01988"/>
    <dbReference type="HOGENOM" id="CLU_067890_0_0_1"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW21408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30035" checksum="B6298CD3698612F9" modified="2015-04-29" version="1">MGRSRTLEYPKTAINKVNRYNVRETYDLEAIHTIINESTYVNVSFNTPDPSNPFPVTLPMIGVAASFDHPSSSLGEPLDIYVHGYVSARLMNLSRKPGGAAADSEPEGLPVTISATKVDGLILSLTPYTHDLNYRSAMLYGYATVVTSPEEKLWAMEAVTNTVVADRWRHTRVPPVSAEMSATSILKVKVVGGSGKIRVGGPRDEKKDTDQAQLVDSIWTGVIPVYEHFADPVPGRDNKVDAVPDHVVKYAKEMRERNQRYAMDVINDTSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRA7</accession>
    <name>A0A0D2BRA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234010.1">
        <property type="nucleotide sequence ID" value="XM_016383307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRA7"/>
    <dbReference type="STRING" id="91928.A0A0D2BRA7"/>
    <dbReference type="GeneID" id="27336069"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08986"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_6_1"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF29">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="372" mass="41118" checksum="E95E6C47A3B0A329" modified="2015-04-29" version="1">MSPTDKKKTIVVVGATGRQGGSVARTFLSSPVSSHWRVRCVTRNPSSEAARGLASLGADLVQADLSSLPSLVSAFSSAHAIYVNTDFWEVYRGALSSGKTTDAQASQLAYDTEIARGKNAALAASQIPGLERYVYSAFGSMKVASGGKYARCYHFEAKAVVVSYIASELPALNSRTSYIYASAYCDNALLYPHKVPLGTPWILWLVTKLPFLLQLMPPPRAKKLEQTEDGGGAGRGGWYQYLMTLPGRMSTSMPTFIPHISTGGYVRCLVEDESPGTKLLAVDWWLTMEEGLRTWERVTNRKAHFLQMPVSLLCRITGIREEVMEGAAFLAEFPYMCEVTEWIEPKHLKNPPPVAMSWEEYLRSRDIKELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BS34</accession>
    <name>A0A0D2BS34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-ascorbate oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_06785</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
            <orientation evidence="7">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234220.1">
        <property type="nucleotide sequence ID" value="XM_016381118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BS34"/>
    <dbReference type="STRING" id="91928.A0A0D2BS34"/>
    <dbReference type="GeneID" id="27333868"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06785"/>
    <dbReference type="HOGENOM" id="CLU_006504_7_3_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239290" description="L-ascorbate oxidase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="157"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="366"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW14004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="70965" checksum="D037F381FC33B19C" modified="2015-04-29" version="1">MAKLAQMLLLTLGLLLLSGWATAKTVTYDFNVSWVNANPDGMLEKKVVGINGQWPLPIIEVDKGDRLVVNMYNGLGDKNTSIHWHGMFQTNTSDMDGPSMVTQCPIPPGYSFTYNFTVNQNGTYWYHCHTDFCYPDGYRQALIVHDKDAFFNDQYDEELTITLGDWYHGFVEDIRFLSLYNPTGAEPVPNSFLLNDTQNSSIAVKPDTTYLIRLVNIGAFVSQYFYIEEHTFRVVEIDGVYTDPTEADLLYLSPAQRYSFLLTTKNTTDKNFPIVTVADSNLLDVIRPDLQLNNTNWLEYDAAAPHPEAVMQVETSADLYPLDDMTLIPHDKMDLLPEPDHEIFLDVIMANLRNGFGYAFLNNITYTKPKVPTLYTVMSAGDLATNELVYGEYTHTMVLKHNDVVQIVLNNQDGGAHPFHLHGHHFQAIERFPTYGEHFFDFADGDPVPYDPSNHTAFRSIPARRDTFVLPPNGYYVIRFVADNPGVWMFHCHIDWHLEQGLAMTFVEAPDVIQQTHKIPQQHYDVCQAAGIPITGNAAAHTEDFLDLDGQPEQVGPIASGFTARGIVALVFSCISAFLGMAFITIYGLSEPKVLHKDISTDDDVTHESVPAGDAEPKVAAAAATGTATGNGAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSB9</accession>
    <name>A0A0D2BSB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane proteolipid 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241546.1">
        <property type="nucleotide sequence ID" value="XM_016376270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSB9"/>
    <dbReference type="STRING" id="91928.A0A0D2BSB9"/>
    <dbReference type="GeneID" id="27328993"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01910"/>
    <dbReference type="HOGENOM" id="CLU_107649_0_0_1"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF57">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18468" checksum="36AB0EA00854E645" modified="2015-04-29" version="1">MSCGDIFLGLLAVLFPPIAVWIKSGICSCDSLINILLCMLGYIPGLIHAWYIIARNPERDYDYEPLDAEGGRVTYYYIRHEPWRRDYGTQEQRGHGRQAPPPPPPPPPKPQNRPAPAPPAPAQSASANGEGSSRPAPQVEGPSVGAGGDGPEAPPSYSEVVRGDNKIQSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BTW4</accession>
    <name>A0A0D2BTW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_07488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234920.1">
        <property type="nucleotide sequence ID" value="XM_016381818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BTW4"/>
    <dbReference type="STRING" id="91928.A0A0D2BTW4"/>
    <dbReference type="GeneID" id="27334571"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07488"/>
    <dbReference type="HOGENOM" id="CLU_007207_0_7_1"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000009">
        <property type="entry name" value="Fe-containing alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="73"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="295"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW14704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="493" mass="53244" checksum="F20EE3D7DC558614" modified="2015-04-29" version="1">MSFSPAIRVARSAAQRSTSLLRAIQYGHPPNCPCHSNPNFHHAPSVFGEAKRRLATPIDYSRTKEYAFEMAASSIRFGPGCTKEVGMDMKNLGAKRVCVVTDANVSKLNAMKQVIEGLNAEGIEFTVYDKCRVEPKDSSVKDAIAFAKPYQPDAFLAVGGGSVIDTAKLMNLYTCYPEADFLDFVNAPLGKGLPITKKLKPLVAVPTTAGTGSETTGTAIFDLVEKRAKTGVAHRNLKPTLGICDPLNTRTMPSAVHASSGLDVLCHSLESWTAIPYHERSPRPTNPINRPAYQGANPISDIFSLKALQSTVKYLPRATKDPEDYEAQSEMLLAATLAGVGFGNAGVHLCHGMSYPISGQNPGYKHSGYQIDTPIIPHGVSVAVTAPAVFKFTGPSNPDRHLAAAECFGKDISNAKKESAGEILSEALAEFLIKLGDQPRGLKPLGFTKESIDDLVEGTLPQKRVLMLAPSLSEEINQEREQLRGLFEEALEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BV89</accession>
    <name>A0A0D2BV89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235390.1">
        <property type="nucleotide sequence ID" value="XM_016379563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BV89"/>
    <dbReference type="STRING" id="91928.A0A0D2BV89"/>
    <dbReference type="GeneID" id="27332302"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05219"/>
    <dbReference type="HOGENOM" id="CLU_004190_1_1_1"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="18"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="841"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1016" mass="112866" checksum="EB90C6B3BF312549" modified="2015-04-29" version="1">MLKAFTAQPIIELKQRDKSRIESILSHSDQLLVGLNTGSLRIYRVKNPPPDHDEDNSSESSSAAAHTDDRPYTLKSSELLREYEKFSKYKIEQLAIFREANILLSLSNGLVSIHDLGTFELQEQLTSTKGATLFAATSNIVKDTTTGVPTLVSKLAVAVKRRLLLWSWHDGELDGDAVEIALSHSIKSLTWASGTKIVAGLTTHYILLHTDSRDIITIVGPGSIGGGPGQEASRLGGPMSYIGMGGMLPTPLATGLGNNEMLLARDINTHFIDRDGEPIGRRQIPWRSPPQAVGYSYPYLLALQEASKGSLEVRNPETLTLLQTIDLPGAVLLQVPNPNISLAHQGKGFLVASERTVWRMQGLNYDSQIDSLIDSGALDEAISLSEMIEETLIKNKAARLREAKMQKAQRLFDEKKFRDALDLFGEVSAPPERVIRLYPPLIAGELAQPNGKTGSLDSPKDDCTNLKSTKSESIASPLKKSKTTTSEADKESIRSARTVDHASNDALSEKELKNAVRELQAFLADVRRRLQRFFNPDQTIRTLSEVQGSMQAEDIQRVTNHLLGITTLDDDGFAQKLLGVATLVDTTLFRAHMYATPSLAGSLFRIKNFCDPDVVMAKLEETERYNDLIEFLYGKGLHRQALERLQKFGKAEHTEDIDPQLHGPGRTVSYLQNLGPSFIDLILEFARWPLETEPQAAMEIFVADTENAESLPRHRVLAFLESIDKGLARAYLEHVVDELNDLTPDLHQRLVALYLEVLATAQSTNQQEILDRLLTLLKTSDQYSPAKTLGLIPRDQALFYEPRAIVFYKMGNHRQALEIYVFKLHDPARAEEYCNQVHLEETINDASKPPSRRRSTTDPVDEQPSVYHILLNLYLNPPKGEKAMWGPAIELMARHGPRLPASSTLEMIPEDLFVKELEFYFRGRMRNANTVLNDSMISAGLRKAEAVRVQAALLLGEGGHTGGRGRKVRIDEDRVCGVCHKRLGGSVISAFPDNSVVHLGCAVRKHTELAGKGQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVI6</accession>
    <name>A0A0D2BVI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235515.1">
        <property type="nucleotide sequence ID" value="XM_016379688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVI6"/>
    <dbReference type="STRING" id="91928.A0A0D2BVI6"/>
    <dbReference type="GeneID" id="27332427"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05344"/>
    <dbReference type="HOGENOM" id="CLU_042059_1_0_1"/>
    <dbReference type="OrthoDB" id="5394254at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="419" mass="43983" checksum="6222AB5B31F88B2D" modified="2015-04-29" version="1">MFDDFLALTTTLIHSGHEQPPTDSASSDSATDSMPPRSRHSKSASVASSSDATTAVKGSDSVNGDMLPPANTTKTAARKRRASRSTASPPTSPVVVIPATKKLDSPPASHEQHQYAKFAGVAILSIFLEAGLQTAASTVGVGDLKAISKIADAWPEIIGLLAWKILKLGIYWTAGFDAYDVASLTLLISTPETILLGLFYDIHPTTLVASTLSSIVANSVPYFLFRSLSPSHNPNTAPKTTLRNRPILTDPYTTVATSLLATAIFAVLLEASFATFLPSWLITHFSGLRSLEKAHLGAGGLPILLLALIPAGVASMEYLFAPSTAAASTVPATPEFDPTTAGFAGHVYHNAWGWYSPRQKSLISRAGLLAYLIVAETIVLLWGTLKGIEFTGAAGYAGIWGVGVVLVGAALDWVGGPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVL6</accession>
    <name>A0A0D2BVL6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235545.1">
        <property type="nucleotide sequence ID" value="XM_016379718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVL6"/>
    <dbReference type="GeneID" id="27332458"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05375"/>
    <dbReference type="HOGENOM" id="CLU_2413282_0_0_1"/>
    <dbReference type="OrthoDB" id="10411855at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254792" evidence="1">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="92" mass="10087" checksum="1EC006B3D2AA6B8C" modified="2015-04-29" version="1">MTVFLYPTLVLLLLLVASSMALPPRQQHYLTTQDNTPTWANEASPASIHHNIHPDEALPVAEAALSVATDFDQTIDLPSAPTSSLPLLQRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXP8</accession>
    <name>A0A0D2BXP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236235.1">
        <property type="nucleotide sequence ID" value="XM_016380408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BXP8"/>
    <dbReference type="STRING" id="91928.A0A0D2BXP8"/>
    <dbReference type="GeneID" id="27333153"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06070"/>
    <dbReference type="HOGENOM" id="CLU_005382_2_1_1"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042935">
        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="432" mass="48172" checksum="E2483773A4C8CC1C" modified="2015-04-29" version="1">MRPSPENIASLVLSKFDTLPQKCKPRSQPDGRREWTPLSAIVLARSGRDPELTCVSLATGTKCLPSSAMVKCQGMVLHDSHAEILALRGLNCWLLSEAKEVLSDPSYRSPFLEFDLSGPSNAARDQPSSPMPPLKLQQDISIHFFTTEAPCGDASMEILIKSMGPGETEPWPVEDTALKTLQGRGHFSLLGYVRRKPARADADQSHSKSCTDKLTVKQFTSVLSFPTDLFIQRTENAYIRTLIVYRDQYDSTGYERAFGRSGRLSNVCSLDHPFRIDPLPEDFPRFMYDRANTDSDHECKAKVTNISALWIRCAGTAAATAADVVEVLMNGVKSGFKQWDQRPTKASIVSRYKLWQLAHSMLPFIRDEEELHRPHHQAWADGLSQSLSAETYAAAKSTILRADRITLKNGTTDALGNWENNDGDYSWNCTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BYP6</accession>
    <name>A0A0D2BYP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06486</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236650.1">
        <property type="nucleotide sequence ID" value="XM_016380823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BYP6"/>
    <dbReference type="STRING" id="91928.A0A0D2BYP6"/>
    <dbReference type="GeneID" id="27333569"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06486"/>
    <dbReference type="HOGENOM" id="CLU_049413_2_1_1"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="359" mass="39720" checksum="851D684FC2642959" modified="2015-04-29" version="1">MATPKRTTGKMGHPEPLVVLPSATHTFSIILLHGRGSNGPRFGLEFLESRTSGGQTLQELFPSVKFIFPTAKKRRSTVLKRVKINQWFDNYSLDDPTERQDLQYEGLTETTQFLHQLIEEEGTTLQGGVNNVIVGGLSQGGAMALIASLSFAAEDHHDSSFSKQVEAASKDAATASTTSSYRGSSLGGFIGMSGWLPFARDIVSAALPNNPDGNDDEYDDHSDPFVRTSSDSHTVLSEETRAPRGPDAEDSISNRLLRAANFARDLVDLEPLQGRVMQDEQKVEMTPREERPNSMPYFLGHGVLDEKVSVHLGTQIRDVLLQLGRDVTWKQYDDLGHWYKTPDELDNIANFLQEKVGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BYS6</accession>
    <name>A0A0D2BYS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236675.1">
        <property type="nucleotide sequence ID" value="XM_016380848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BYS6"/>
    <dbReference type="GeneID" id="27333596"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06513"/>
    <dbReference type="HOGENOM" id="CLU_1415180_0_0_1"/>
    <dbReference type="OrthoDB" id="5150159at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="192" mass="21318" checksum="51BD3E2FC2D6B0D9" modified="2015-04-29" version="1">MEGNTLIRVSHHSADWYSNDVFDATAEELCAIEYICSFFPVWRAEPEISSEEMSDAGGSSGDGAREPGRSSTTTTNTTTTTKKCIWLVNEMKEPVLRMSNLHPLYDLLMFRTDDEPGDEPGGDDDGSTPDLSGEVDLSNPQYSPERMRQMILTVRGDGDLERDSRAWWSCRGNPPANARLVRCHGPPAESDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZX9</accession>
    <name>A0A0D2BZX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartokinase</fullName>
            <ecNumber evidence="7">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_04099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237125.1">
        <property type="nucleotide sequence ID" value="XM_016378448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZX9"/>
    <dbReference type="STRING" id="91928.A0A0D2BZX9"/>
    <dbReference type="GeneID" id="27331182"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04099"/>
    <dbReference type="HOGENOM" id="CLU_009116_6_4_1"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000029">
        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000033">
        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="468"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW16909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="532" mass="58132" checksum="E904634378D3633D" modified="2015-04-29" version="1">MTSDIVSNGVDCPTPLTAATPLTDRATSPNPSSTNVLKFGGTSVGKFPLDIVNVVKSSSVDNNVAIVCSARSSNTKAAGTTNRLLRAAAEAEHHREFKHLIEEVRQDHIETAEFYINSDKICSRLKAEIEEECSLVVRILEAAQTLGETSPRSRDKVMSTGEKLSCRFMTALLQDQGVDAEYLDLADVIDFTVPHSLDQHFYDNVARRLGGRLHNMTGKVPVITGYFGAIPRGLLTTVGRGYTDLCAALVAVGIKAKELQIWKEVDGIFTADPRKVPTAKLIPQISPAEAAELTFYGSEVIHPSTMDQVIRARIPIRIKNVMNPRGGGTVIYPDTPTELESGLAGHDPTLFRSRSSTLLSEQGKPKRPTAVTMKHKILVMNIHSNKRSLSHGFFAGIFATLDKWRLSVDVISTSEVNMSMALHSEAPLYTGGGHDEYRIVDQDLRGAIEELQRYGTVDIIPEMAIVSLVGKQMKNMVGIAGRMFSTLGENNVNIEMISQGASEINISCVIAERDADRALNILHTNLFTFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0F8</accession>
    <name>A0A0D2C0F8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237320.1">
        <property type="nucleotide sequence ID" value="XM_016378643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0F8"/>
    <dbReference type="STRING" id="91928.A0A0D2C0F8"/>
    <dbReference type="GeneID" id="27331378"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04295"/>
    <dbReference type="HOGENOM" id="CLU_073511_0_1_1"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="193" mass="21149" checksum="A3E39D4A4E9ACCC4" modified="2015-04-29" version="1">MSAEVAEHPSGPPARQVVYCGVCSLPPEYCEFGGTVKKCEEWLHKNHPDMHQKLYSAEALSANLSALSVEAQKRAEKDAAKKTAKAAAAEQREAERKAEAVVLIKRVERNKRKYVTVVSGLEDHGLDLKKVAKELGKKFATGSSVTKTASGGEEITVQGDVSDDLYDWLTEKYPDIPEDNIDMKDETKKKGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C4C6</accession>
    <name>A0A0D2C4C6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238660.1">
        <property type="nucleotide sequence ID" value="XM_016377090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C4C6"/>
    <dbReference type="GeneID" id="27329815"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02732"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF27">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="41"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="525" mass="56807" checksum="FED2EC4EAA65A3D8" modified="2015-04-29" version="1">MTPTKPEIVAFQQTEFASTPPQGREIIEHPKGWANWRVLLNGIIIGLSVGLFGYDNSFAAPLVALPLFITKYQGAGIAFTARNLDLVITVPLVGAALGTFVATPLMRYLGRKKAFLVAYFLLCVPGSFLQLFAPDLGALVVGRFWNYVGVSVLTTTAPLYLSELVPPHVRARSVGFCIAGSSATGIIGTTVVWATARLTDSRQYKVPLAIQVALPAAFGLLTLLADESPSWYIQHDQLEAARSTLMRLRNNKVDLVEAELTLIQAAMSASTARQAGVRFWDILKPEHLKRTLTAGALLPLSQVGGQILVLTYSTVLLVQSGVANPFEITIIISCLTFLGTIVGPVLVDSAGRRPVALIGFSILFILDMTAGGLGAAGLTTKSQRLGLAAVFIIFAFFNAVSFQSLSYLLPTEVSTAALREPTVSWAVFWSYATAIITTFAVPQITAPDAGNLGVKTAFIFGGCVFLTAIWSYFYLPETKARTVAEIDEMYRISLPMRKWRKHQCQVLNEAALGLPQDETGRDTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6Y1</accession>
    <name>A0A0D2C6Y1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD hydrolase, family IA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239550.1">
        <property type="nucleotide sequence ID" value="XM_016377980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6Y1"/>
    <dbReference type="STRING" id="91928.A0A0D2C6Y1"/>
    <dbReference type="GeneID" id="27330711"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03628"/>
    <dbReference type="HOGENOM" id="CLU_045011_14_1_1"/>
    <dbReference type="OrthoDB" id="2107174at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050155">
        <property type="entry name" value="HAD-like_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434:SF1">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27434" checksum="1FBAFA6BEF222F69" modified="2015-04-29" version="1">MPKVKYVLLDCDNTLVLSERLAFEACADLTNELLAKYDIPDRYSVDSLLEDFVGQNFRGMLVGLQKKHDFQMPPEELEEYVKRELGEVIKKLSAKATPCPGVPEELERLHKAGYPMAVVSTSAKPRVVASLEKVGIDHYFPNAHVYSAATSLNPPSSKPDPKIYLYACEQLGVKPEECITVEDSKSGATAAMRAGIPLVGYVGVYGIEEGKEKMEQMAKLLKEQCNAAAIMYDWKEFPEILKKLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8F6</accession>
    <name>A0A0D2C8F6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_00414</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240055.1">
        <property type="nucleotide sequence ID" value="XM_016374779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C8F6"/>
    <dbReference type="GeneID" id="27327497"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00414"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000254">
        <property type="entry name" value="MAL31p Maltose permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF49">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="112"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW19839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="615" mass="68152" checksum="14C89B7B971DF0F2" modified="2015-04-29" version="1">MTDANNNGHRPGFSRESGASTDKAHPSEFLEFVTLGDPTLQHLERLKTQQEQESNQQTQVNVTNSNDELFSGLFHAIPDLRRLSTDARAATKAEHTMTFLRGCRLYPKAIMWSVLLSMTIVMEGYDGALINSFYAFPVFRKSYGTPTNHKPDDPNSKPDYQISPAWQTGLTNAAVSGEILGLMFNGFLTDKFGYHKTMVGSLIAMSLFVFLAFFAVNIEMLLVAQIFCGFPWGVFQTLSTTYAAEVMPMTLRAYLTSSVNMCWLIGQLLAASVIRALVHNTSEWSYRLPFGLQWAFAVPILIGVLFAPESPWWCVRHEKIDEAKKSLLRLTTKGTDPDFNADETIAMMQQTNAVEKYLNGGGVSYLDCFKGTDLRRTEICCVVWCTQALGGGAMTGYAAYFYEQAGFNTANSFNLAVGMYAGAICAGILSWVGMRKIGRRTLYIGGLAVSLVLLIVTGIVGTLPETNTTSWTLGSMLIALTIVYDFTIGPVCYVLVAEVPSTRLRVKTVVLARVAYNIASIVINILTPRMLNPSAWDWKGKSCFVYAGTALGCLVWCWFRLPEPFGLTYMELDILFEKKAAARKFKEFQANLAGTGYFSLTQAGTRSDSVWRGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C9Y6</accession>
    <name>A0A0D2C9Y6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240595.1">
        <property type="nucleotide sequence ID" value="XM_016375319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C9Y6"/>
    <dbReference type="STRING" id="91928.A0A0D2C9Y6"/>
    <dbReference type="GeneID" id="27328037"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00954"/>
    <dbReference type="HOGENOM" id="CLU_076914_0_0_1"/>
    <dbReference type="OrthoDB" id="333176at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="128"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="212" mass="24635" checksum="FAB1ED7F3F209EE8" modified="2015-04-29" version="1">MPRFTEGTGIPIRNVQDVLGAPKAPLVPDHIRVKNRRKRYLDTHPEYFGPQLELADPLLYDRLVRRFQTPAEREAEGRQKGYSGILEADIYRSEAKLDALRHPDPNSMFTYKRGLNGEILAEERDEVPANKEDGYARWRWEMETRFMRGGDDDFDYSTVDDNPEYDDRAIEEQDAEDRYFDAQEPEFLVESNEENSQSPGKVLQGETGIQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAY2</accession>
    <name>A0A0D2CAY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240950.1">
        <property type="nucleotide sequence ID" value="XM_016375674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CAY2"/>
    <dbReference type="STRING" id="91928.A0A0D2CAY2"/>
    <dbReference type="GeneID" id="27328395"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01312"/>
    <dbReference type="HOGENOM" id="CLU_138649_2_0_1"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13211" checksum="36D9C4C93CEF8F2F" modified="2015-04-29" version="1">MFARSLPRLAARSSQTILSATSRPTTTTTRIAPLVLATRTPLRLASTHSAGHDDHHGAAATGGDHGAHHGGGHDDHFDPPAGWLWGERPGEKYEKEGWEGLAWVFVGCWVVAIAAYTMKEDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CBS6</accession>
    <name>A0A0D2CBS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_01538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241175.1">
        <property type="nucleotide sequence ID" value="XM_016375899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CBS6"/>
    <dbReference type="STRING" id="91928.A0A0D2CBS6"/>
    <dbReference type="GeneID" id="27328621"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01538"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW20959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="552" mass="60585" checksum="2FE1E168E2C7437B" modified="2015-04-29" version="1">MSRQGSLRLSVTDDVNRIEAPVTWKAYLMCAFASFGGIFFGYDSGYINGVNGSDIFIRKVEGPDATALSSSHQSLIVSILSAGTFFGALIAGDLADMIGRKWTVILGCLIYMIGVVIQMITGAGDALAAIVTGRVIAGIGVGFESAIVILYMSEICPRKVRGALVAGYQFCITIGLLLASIVVYATEGRNDTGSYRIPIAIQFAWAIILAGGLMTLPDSPRYFVKKGRLEDATISLSKLRGQPRDSEYIQVELAEIVANEEYERHIIPDSGWFSSWANCFKGSLWEAKSNLRRTILGTSLQMMQQWTGVNFIFYYSTPFLQSTGAIDNTFLISLIFTLVNVCSTPLSFWTVERFGRRTILFWGALGMLICQFIVAIVGVTVGFNHTHPDPSDPDVSLADNISAVNAQIAFIAIFIFFFASTWGPGAWIVIGEIFPLPIRSRGVALSTASNWLWNTIIAVITPYMVGEEHGNLKSSVFFIWGGLCTAAFVYTYFFVPETKGLSLEQVDKMFEETTPRTSAKWKPSKTFAGRVARDGVLEKDVVDQVERRGSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCX7</accession>
    <name>A0A0D2CCX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_01939</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241575.1">
        <property type="nucleotide sequence ID" value="XM_016376299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCX7"/>
    <dbReference type="STRING" id="91928.A0A0D2CCX7"/>
    <dbReference type="GeneID" id="27329022"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01939"/>
    <dbReference type="HOGENOM" id="CLU_324916_0_0_1"/>
    <dbReference type="OrthoDB" id="4139337at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00306">
        <property type="entry name" value="Peptidases_S8_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="804"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="10">
        <location>
            <begin position="328"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="588"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW21359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="888" mass="99049" checksum="C52ED3C85B77D1CE" modified="2015-04-29" version="1">MIDGAEVDDLEDDFGDDGWQFVDLLAGDAGEMAEEALRRAAESGNEHKAYDNIINSIKLLGLSAVIGTSSSEQRSKAVSAMDNAVIETLKSGSKTARHVATRFKKFTQRLTVDPGSRSNQAAIQRITEITNYLSERDASYDDATQARERHDRQKFRERFEIEEYPDSVTAALHGTFYSDTYLPCTCQEDDKGLCLSKRYICALRLDGYTRVPGDDNHFFFDSVIAKTDDDSYEWTPIQFQLPRRTRSVVVHVGRPASSADIENDLSSSQASPGTLEDFCKIFTWGIRCFRICVTQDHKSNLICCSIERSFHNIFPQNAKPMRLSSALQQDELSARHKIFLAFAISKAFWQYYGSDWMKVEWNLETIQLLRTKNAESDAPYLNVKILEEELTQHDHNPKGASGKIPALHPWPSILNLGLLLVQLGSVTSEKTDLITIPGRLTEIKKNNYICISCCKEISADDSWPTIDIPGRDRLRYRRIVEECFPTHSAIPKALFKDGLDAEGSRLALKENIVRPLFELLQDMMDPDETPFLPPHGVQADPVTVLQGGNGLPRLVNSPSDIAADWLFGTTNSWLHSHISTQIAKYQRPKIAIIDTGFDGNARFVDRKLKLRLNLHSTAGGNHNWRDFWEAKAEPQDDDGHGTAMLSIVHRIAPFADVCVARIAGEDKDLKTNPGKTSNNLAEAILWAVKEQKADIVSLSLGWEQEQRVDKNRAISNAISEALAHCNQNLLIFAAASNRGGSKRELFPASHGSVFSIRGTNTKGKHEDFNPSLPSRGGEVFGALGLDVPTENRGRSPPYQTNRTGTSVATAVAAGLAAIILGYINIHDHKKGRWDNVRIHQGYQNLLYKLSTEPDGRKHFITLDNHSKEYEQADLDAALSSASNLKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y598</accession>
    <name>A0A0D1Y598_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230312.1">
        <property type="nucleotide sequence ID" value="XM_016385368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y598"/>
    <dbReference type="GeneID" id="27338139"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11056"/>
    <dbReference type="HOGENOM" id="CLU_141137_1_0_1"/>
    <dbReference type="OrthoDB" id="5201563at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="120" mass="13706" checksum="F71DF91D2F747478" modified="2015-04-29" version="1">MSVTTTENQVSYSIAQTLREYDVHHSNQEAEDAPLETPTNLPTSRNPTNWPTSHRRVPPYRPVNRNLDLSVRGTANAVEAAFVFTMLHGVWINAAASQFWRKTGGRINDKYFRYKIGGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y840</accession>
    <name>A0A0D1Y840_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Grh/CP2 DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10431</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231347.1">
        <property type="nucleotide sequence ID" value="XM_016384745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y840"/>
    <dbReference type="STRING" id="91928.A0A0D1Y840"/>
    <dbReference type="GeneID" id="27337514"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10431"/>
    <dbReference type="HOGENOM" id="CLU_012196_1_0_1"/>
    <dbReference type="OrthoDB" id="7680836at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="7">
        <location>
            <begin position="211"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="750" mass="83715" checksum="52EC98FC86260205" modified="2015-04-29" version="1">MSPTLLSSDHEEDVTTDTDYFSRGFDTQPEAKEQDATPKPFADNWRFTPSIMDPNSFAFSAFANQPPGYYTPTPGGFGTLYHPQAGDLHTPGMGMNTPLSMPHSIHSLHAQDPMMHLQHFNPHLLHQPHVFHDPFHQQAPVHVPPPQQPQAFAPQQFLQHQDSGYVAMDDTPQKTTPTQLEMGGQRQLSRGRSIQQSMPGMVGMTSLPMGEQFRFHTTLNAPTAMVRHADEIPITYLNKGQAYTMSIWDQTPPMTQLPGNTPFQYRTYVRVSFEDEQQRARPGSCWQLWKEGRGSNEAHQRGGRLLAVEYVEPELGDDELRKAQVQLEKASFDGFAVTWFPDSVNGGPDCNISLRFNFLSTDFSHSKGVKGIPVRLCAKTELLSPTGTGNEPEVCFSKVKLFRDHGAERKLSNDVAHVKKTIEKLKQQIAQAEAGLVNSGKRRRSGSVAKPSGSRPGKVVKHKRTWSVDSESEGLKFSAEEDLQMKLVSMQDMFSSTRPISVLFLRGDAEDDPDLHPVKLPGDDPDMKEIVRTTTWESRPSVSDSPTSNAGSPSTSSASQATPKKKFSQLQHSAIQEEGESEAENRPTTSTSRLIKIPKTEPDSASKKDLFAVDVDSSYHPPIEKPIRPVACFYVRQKDAAKEYYRAVYLMERTVKALIHGIAEKFNIDAYRVTQVTHINSRGLHIIVDEDVVRELAEGQDMVVEFTPGQPDSSQKQEFVARSSTEVMVDGDIGPTDTSILDPLEMWLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y9K4</accession>
    <name>A0A0D1Y9K4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231882.1">
        <property type="nucleotide sequence ID" value="XM_016385280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y9K4"/>
    <dbReference type="GeneID" id="27338051"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10968"/>
    <dbReference type="HOGENOM" id="CLU_1835229_0_0_1"/>
    <dbReference type="OrthoDB" id="4160180at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="155" mass="16751" checksum="6ECE55B1624BB8CF" modified="2015-04-29" version="1">MSLPTNKPSLFSRLAHSSSSSLRSDSSSSTTSTISSTPSGCRDYQRARYAKDGKGFDFTSTYPYSTNGQGVDETLATAVAPSFPLGCRDFKLRYAKDGKGHDFRATYTSAETASVDTVPLVDTVSSVPVPGDFKLRYAKDGKGHDFAVSYPYDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCQ3</accession>
    <name>A0A0D1YCQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232937.1">
        <property type="nucleotide sequence ID" value="XM_016384314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCQ3"/>
    <dbReference type="STRING" id="91928.A0A0D1YCQ3"/>
    <dbReference type="GeneID" id="27337082"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09999"/>
    <dbReference type="HOGENOM" id="CLU_024934_5_1_1"/>
    <dbReference type="OrthoDB" id="5295362at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002236858" evidence="1">
        <location>
            <begin position="18"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="294" mass="32887" checksum="46AE2723030979C4" modified="2015-04-29" version="1">MALHFDFLLDGIFAVTAFEIAATYNDGNYIYAALEYQTSSISAFRRHLDNPLPETIEPMLAFSLMFMVLTLASSQARLNNASSCLPNTDSTTYFSGNGILESTVTHFALLQGVSAIVERKPEYVTNSPCINRLKPFKELPSTAVDPEIESTLSKIGDCNEARITSTVNELYEHRVSQISLWETCKNALSMLRECFAKCADESHSGYTLGWLNMAGDEFIKAVIAEDTTALLLLMYWGVLCQKFGHQVWWARSYGGLLVDELVRSKLADITDDETKGLVTLAQERVRQYRLRGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YD23</accession>
    <name>A0A0D1YD23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233077.1">
        <property type="nucleotide sequence ID" value="XM_016382374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YD23"/>
    <dbReference type="STRING" id="91928.A0A0D1YD23"/>
    <dbReference type="GeneID" id="27335131"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08048"/>
    <dbReference type="HOGENOM" id="CLU_002517_0_0_1"/>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1275" mass="136292" checksum="E6DD0E4844370305" modified="2015-04-29" version="1">MAQQSAQDVVNQSQSAGDNLSSSDAPATTSTPDIKVSGDEIGVGEVAPKENGTHTLANLKMDDLEDASGRSDTDTSRADGSVTGDKPAESKPLKKFTAKPVSFAKYSVPKVVAANAAAKGMDKVTLPTLSASSLTSSSRPRLVAKTTSALQTQGKSYKSATPDPMQVWNKNRVTPQPSTKHLTDEELKQQYGIHLTSRIQADGEGKEAKWADIDDDEDDWAPETIEWNDGTKSTLTPIEVLPQAKQKSATTSDADEKPKPAAPPKPPAPHFTSSVGPNATVLKLGASAERQHAQKVANLQTKTQSEKTSNGSSKSTPAVAPAKSPWAALPPVDKVSPIAINPQPVPPPQGRFSSQNYAQPPTGLTAPSPATEISADDFNRAWRDAIPGPPRELFVPTSGRYEAVPEGRRRMSRNDQGFRAPAVLQRPSQTDPHAPAEPSAAFQTHRTSTDQARRRASSTVSGGSGSFGRRMSFKSGETPTSVFGPSKSDVESLVRPSSKDGPSSQTQVPAYQSRGATDQMPAGSAPPSDADLEVQRAQQKALMKENIERAKRRKIEEEQRLEAEKRERIRQKLASLGPDPKLTKKHAEEKTVEDAGTGKESKKAAEESAASAVHATTHSPPKPPQPLASGEPQQYGMMKVHPLDSVKKLGGSLSRQQDSQKLPVRVKLDSAGLEESKQETSQMPSPVVNGVRSVPELRKSSGQEPVASSEPSPKLPKPSSSGNDARSGWGDLRSDHRSPQGANLWGISSKSALGNGTFDHGLAGYAPQDLSRTSSSVQGWMNGRTPHTGRSPQAQYVNHAAPESRSFSYQPLASPDQGPLAADSEADSLFPTTKPAPIAPPHSQQAHGPGAVHSLQNPPKPHAIDAWANFHQVAGQQERAENERLQRELVARREEELRTGVRQGPQYTFNETWKQVHVGDQAGQRHVANIAESAVPASNLFGAVGTIPGTDMGSRMMSGPGGRGSRFFPQPIGVPPQDRRAFTYSHPEPPRSPSPPPAEEYSSFHPAFDGDLRSPKVHFPPAKAVVKLPPVMPPTPPSPTPVQPADVSHTPLTWAARVSAPPQSFRSASTPIVQNPSWQERFNGLLGKKSSPVPEPVHFASAALAIAPSSREPLDVQHVLVPAASVSMPVDADSGIPVTEVSIATKDVESEDDLFEDREPGSLPIIELPTGAPPIQWAPSFASRIAPAPVDPVSRHPFMVNNLREWHGPSKQQYALIRLPGQTKPIRKDIPVKSAPPSSGGKSQHRNGGNSGASHVGKRSRNRDGPRVRQASKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YES0</accession>
    <name>A0A0D1YES0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233762.1">
        <property type="nucleotide sequence ID" value="XM_016383059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YES0"/>
    <dbReference type="GeneID" id="27335817"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08734"/>
    <dbReference type="HOGENOM" id="CLU_265820_0_0_1"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF13">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="106"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1250" mass="140403" checksum="ED914F4C3D6B7309" modified="2015-04-29" version="1">MASNHQDRHPTFHTPSFDSNRESTGSSRGENGEWERASTIDGDNDATTNKPEENVPEAAHVGTTLREKEERSAGSEPETFDKIEITEDDCMSELGYSWPEWKKWTVLTVIFLVQLSMNFNTSLYSNGLGGISEEYGVSAQAARCGAMIFLVMYAFGCELWAPWSEEFGRWPILQLSLTLVNIWQLPVALAPNFGSLMVGRALGGLSSAGGSVTLGMIADLWDADNQQYAVAYVVFSSVFGSVLGPIIGGFVEQYLAWRWAIWIQLIFGGFVQAAHFFLVPETRTTILMDRIAKKRRKATGENIWGPNELEPFRDRFSVREVLITWMRPFKMFLTEPIVLTLSLLSGFSDALIFMFIQSFALVYGQWHFSAWQTGLAFLPLGIGYLLAWISFIPAIKRNIKERERNPGNEKAQYESRLWWLLWTAPCLPIGLFGFAWTIQGPPIHWIGSMIFSAIVGIANYAIYMATIDYMICAYGPYSASATGGNGWARDFLAGVLTIPATPFFENIGGRYHLNYAATILACIATLLVVAVYAIYWWGPELRKRSPFAQSLAEARVDNDGRRLSYLRSYSGTSGSRRASRPNSIQQAKVPIPRTIRPIRRSHGAAPAIQSPVHTHNLTPGSSVGNEVGGRLESGLRVSQSNIGYQVHDASAKRPSTINTAGLAELTVEELHTYNNLLSLEKDHDLATSPPPFAGTGISLSTSEKIAWQIHLASALPPRSHCDLFIAYFFESINWIYQAIHAPSFRQKYESLWEYPVKDVDLVWIALLYVLISLTALYIDPKACESVGYDASDIRNNGHLWFRLSRQALHAGEYDSRPCLTQIQVFIQSQSYWYATKAVEALNSAMGQAVRCAQAIHLDKDRDPATNLTSELRHRLWWDLCCSDTYQSLCLDRQPLIQAHLSDVPLPQNCEDCDITSTMINCRPLEEPTVMTVHVLRAGLFKVLSKLYANNASASTSYEEVCAIDQEILTIVDQFPWYLKTHRDQGRFTVISPTLPPVYDHIQWQHHLIHNSICVQRIRMYRPFLRSPFHNDCWSKCIEAVEGAFAVYHAIRNANPVRFQRSQKMVAQSYQIFCSAVSIAVFLLVERPALPSRMQSDIEVVIQDLQRIVQNHSSIPMAVAGRVVLTKILDAYNLSSRQQQGLNHEETVSNSNWHTLIPEIYAHMGGQAKTKTYLDRCAVSHIVNRESSMSGSYSPLNLQSKTTSKAGVITATEPTYMTNDSNSFDADFATSFGFDLHFDVLSWGIEDFEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YGF7</accession>
    <name>A0A0D1YGF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stc1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234292.1">
        <property type="nucleotide sequence ID" value="XM_016381190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YGF7"/>
    <dbReference type="STRING" id="91928.A0A0D1YGF7"/>
    <dbReference type="GeneID" id="27333940"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06857"/>
    <dbReference type="HOGENOM" id="CLU_067851_0_0_1"/>
    <dbReference type="OrthoDB" id="3514033at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024630">
        <property type="entry name" value="Stc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12898">
        <property type="entry name" value="Stc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stc1" evidence="2">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="258" mass="28473" checksum="1FC69B21E157C27C" modified="2015-04-29" version="1">MALNADQSSLNNVDVGNIIECANCSRKLFRSRFSNNQFKKFQSEVLHARRGGPPAKLPRCHECTAGNVMELKCTSCGYTKAIDFFSGQQRRNPDEAKCINCQQEIQDRLPGLKESAEEEQIRLELRANRLDPLSGMSSIGSSLPSATGSIAPSQGGYQKSLTTDGRVRVPRQAQSEWGDSQLSRGSSSSAGSEFPGRWANSTSEYPAVISNRGFDRVGAYKPPVSERARHQLDREQIQKAQAELGTQEESDADEDWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YI16</accession>
    <name>A0A0D1YI16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_07335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234767.1">
        <property type="nucleotide sequence ID" value="XM_016381665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YI16"/>
    <dbReference type="STRING" id="91928.A0A0D1YI16"/>
    <dbReference type="GeneID" id="27334418"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07335"/>
    <dbReference type="HOGENOM" id="CLU_039478_1_1_1"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002236985" evidence="5">
        <location>
            <begin position="25"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW14551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="427" mass="46346" checksum="C165CE907E0C5E6F" modified="2015-04-29" version="1">MRFSSLSLSSCCFCLAALLPYSSASFYDNPEVEIRPETEIPLDELKAKWDSDWSFSGISTFAHLKHVKCLTTPYEPFDIGIIGAPFDTAVSYRPGARFGPRAIRAASARQISYRGFNHRAGMNPYQSWASVLDCGDIPITPFDNALALHQMTTAYTELISRRPLSYTNPPSHTHPKLISLGGDHSIALAALRALGKIHGRPIAVLHFDAHLDTWHPGAYPSVWANTPTQADFTHGTMFWVASEEGLIANGSSVHAGLRTRLSGNEWADYDNDERQGFLRIEADDIDAVGVSGIIELIMERMGTETPVYLSVDIDVIDPGLAPGTGTPEPGGWTTRELIAILRGIEGLNVVGADVVEVAPAYDGMGEATALAGAQVAYEILTSMVRRGLRERGEDVVLTKPGNAKILAKAKEKAEARAKANSKARDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIE3</accession>
    <name>A0A0D1YIE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bud22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234922.1">
        <property type="nucleotide sequence ID" value="XM_016381820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIE3"/>
    <dbReference type="STRING" id="91928.A0A0D1YIE3"/>
    <dbReference type="GeneID" id="27334573"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07490"/>
    <dbReference type="HOGENOM" id="CLU_029647_0_0_1"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="40"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="506" mass="55268" checksum="47F50850EBC88025" modified="2015-04-29" version="1">MGKRKREADEDQDHDDKVQVPDADPALSNQISRLKSSLSRGIKSLHSTLKLARGFERQKLGRRQKSATDNPHQLLRLREEVIVLKQLDLERTAKQYLVKQLVRSTRTKSHPAVVSLYGPDPHLEQPKSTAEGNVLGRLFNSAPVKQVLPGLLNGLFDVLGVSAPGGGKAEDGANDQRRRTGKKSNVGAEPEPGSGSGSGLSENERSLVFSGDEVDEVRDESDGSFNGFSDGKSGDVHSDDDDDEPERPDYISDVEMDRLLSEHQDRLASSSDDDEEDGDDDRDDLDLSTRHTDGTTRGRSSRDDIAVSLSPEPQLSSRSKNTKRVQKAASVAPTSTSTSFLPSLSLGGYYSGSESGDDGDNDRDYSDGPPSAKTRNNRRGQRARQKIAEKKFGKNAKHLAKQKDKQRGQDSRNAGWDAQRGAVTGKQHGRDRFRNGSGRGVGDGGGKGDGRRDQRDQDARGSRAAPLQPKKRDDQGSLHPSWEAAKKRKAQGESQPTFAGRKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIQ2</accession>
    <name>A0A0D1YIQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235032.1">
        <property type="nucleotide sequence ID" value="XM_016381930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIQ2"/>
    <dbReference type="GeneID" id="27334684"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07601"/>
    <dbReference type="HOGENOM" id="CLU_036005_0_0_1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="59"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="363" mass="41019" checksum="0CC88583110DAF38" modified="2015-04-29" version="1">MIAPLGELKAQSKEPLYPKYLPHYDPLEKVEEVGPFEHVDPGHRADPKMPNLLQNATSITELSPHCGTELLGVQLTELTTEGLDELALLTAQRGCVVFRDQTYTDAGFGEQAKIASHFGPLHKHGWMPHPQDGPVEFVIVYDSKDDLRIRKSWARKSPIQFHVDQSPERQPPGLTFFCMLESPDGSGGDTIISNTGRAFERLSPSFRKRLEGLMAVHTTANPIMREIRDNGNNSVLRRPITRSIHPVVTIHPVTKQKGLFVNSSYTQSIVGWDEEESDYMLKFLFDHINRGQDFSCRVRYEPGTVVVWDQRITQHSQTLDYAAGDRRHAFRLTPLANVPIPSKIEEDDGECQKDEARVMLNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YLF5</accession>
    <name>A0A0D1YLF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_05916</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236082.1">
        <property type="nucleotide sequence ID" value="XM_016380255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YLF5"/>
    <dbReference type="STRING" id="91928.A0A0D1YLF5"/>
    <dbReference type="GeneID" id="27332999"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05916"/>
    <dbReference type="HOGENOM" id="CLU_016734_1_2_1"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="390"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW15866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="739" mass="79464" checksum="B91B6D3AAA8FB690" modified="2015-04-29" version="1">MAEGIKATFAQCKKENRPALVGYFTAGYPTKEECPDIMLGLQAGGVDVIELGLPFTDPIADGPTIQKSNTVALANGVTVTSCLEFVREARRRGLKIPVLFMGYYNPLLRYGEDRMLKDCKEAGVNGFIMVDLPPEEAVRFRNNCKTVGLSYVPLIAPATSEKRMQLLCKIADSFIYVVSRMGVTGATGTLNTKLPELLERVHQYSGGVPAAVGFGVSTRDHFLSVAKIAEGVVIGSQIVLELGKAKEGERANAVREYCSQITGRKVGEFNTTNGLTREVGIVETMDAAKEPNATTNGLNGHQVQVDKVITDADIPSEPGLADQLDALNSATNGTTPNPDAIPAQFGQFGGQFVPESLMDCLAELEDGFEKARNDPEFWKEFRSYYPYMGRPSSLHLANRLTEKVGGAQIYLKREDLNHTGSHKINNALGQILLARRLGKTRIIAETGAGQHGVATATVCAKFGLECVVYMGAEDVRRQALNVFRMKLLGAKVVAVEAGSRTLRDAVNEALRAWVVDLDSTHYIIGSAIGPHPFPTIVRTFQSVIGQETKEQMQELTGKLPDAVIACVGGGSNAVGMFYPFSKDPSVKLIGVEAGGEGVETGKHSATLSGGSVGVLHGVRTYVLQNEHGQISDTHSISAGLDYPGVGPELSSWKEASRAKFINATDPQALIGFRTLSETEGIIPALESSHAVYGAMEVAKTMKKDETIVICLSGRGDKDVQEVADELPRLGPGIGWDLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPW9</accession>
    <name>A0A0D1YPW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04467</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237492.1">
        <property type="nucleotide sequence ID" value="XM_016378815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPW9"/>
    <dbReference type="STRING" id="91928.A0A0D1YPW9"/>
    <dbReference type="GeneID" id="27331550"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04467"/>
    <dbReference type="HOGENOM" id="CLU_050888_0_0_1"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="327" mass="38048" checksum="28095B9A8CA22571" modified="2015-04-29" version="1">MSSDEIVWQVINQQFCSFKLKLNTKEQTFCRNEYNLTGFCNRQSCPLANSRYATVRPDPETGALCLFIKSPERAHLPSKWWEKIRLPNNYEKALAQIDDKLVYWPKFYVHKCKQRLTRLTQVAIRERRIAKEEERLGEKLVPRLAPKVRRREETRERKAESAAKVERAIERELIERLRSGAYGDRPINVEEGVWKKVLRGLERAEKGEEEDDEEEEEEVEVEGEAEVEYVSGMEESDAEEEAMEDFDDWFGGESPDEDEFSDEDDDDEDSDDDDDDVSEDNEDDGAGLGKKRKRAAPPPSAKKQPKKRGKVEIEYETELPQKQSVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUM5</accession>
    <name>A0A0D1YUM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NCS1 nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239167.1">
        <property type="nucleotide sequence ID" value="XM_016377597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUM5"/>
    <dbReference type="GeneID" id="27330323"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03240"/>
    <dbReference type="HOGENOM" id="CLU_021555_2_0_1"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF1">
        <property type="entry name" value="URIDINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW18951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="61716" checksum="A67883D54F4808F5" modified="2015-04-29" version="1">MGSVSFFSRLVKRIETKEYRNAEAENRHQWLDNNDLRPVPIADRTFGWKSYFWFWLSANATPASFYGVSAALAAGLSVWEALACQLGGQIMIATVFVFNGRAGAAYHIPYPTIARASFGVWGAYWPVVNRVVMTLVWTGVNAVQGGQCAYVMLHSLFPSIARIPDVFPDGASALNSGGMIGFFLFWILTTSLLHIKIPNLRPYMYTKLGIFFICSICLLGWALAEAGGIGPVARQGSTIHGSTKSWTVARYVFIYCANGATYATNASDFLRYAKKPKDAFWPQLIGFPLSTFLVGIIGNLIVSSSVITFGELIWNPIDFMDALLEKHYNSATRAGIFFLALGFLYASIISSIFENSIPAGNDLAALWPRFITIRRGFYIAAIISYAMCPWYILGSASSFVAWLASYQIFLSSITGVMLCHYFIVSRGYLKISDMFTPAHSGLYYYSRGWNYRAYVAYLVGIVPNFYGFLGVFGVSVTLPATRMYYFAYPMGLALSFGTYWALNKLNPPICSNMGQMFREVGSEAEDAVIESEVVAAAVDLRTSKGGMGLDASEKDAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVT6</accession>
    <name>A0A0D1YVT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenosine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239607.1">
        <property type="nucleotide sequence ID" value="XM_016378037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVT6"/>
    <dbReference type="STRING" id="91928.A0A0D1YVT6"/>
    <dbReference type="GeneID" id="27330769"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03686"/>
    <dbReference type="HOGENOM" id="CLU_039228_7_0_1"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF7">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="371" mass="42421" checksum="F1FB4D8E64FC404B" modified="2015-04-29" version="1">MAADEKFMPLEERKALRAELAAGDDYPFMLALPKVELHLHIEGTLVPELRWKIAQRNKMTLINPRSSQPYESVEQLAANYETFTFFESYYEGFKVLLTKQDYFDLAMNYFERAAAMNVRYVEVFFDPQGHTQRGVSWDTFMSGFKEASTKAEQELGVRSAWIMCILRDESPESAMEHYEAALDYRDMIIALGLDSVSYKLPPSLFENVWSRARADGYFKLTAHCDNGAEEDVWDHIRETACQVGGYGADRIDHGVDAADDAALIKIIKERGLGLTLCPCAYLRHYPVEAMYSKIALLYKEGVKFSIGSDDPAYMDDNWQVNNMLVVKHKCGLSDEDMVVVCKNAVDMCWSTAEVKKAISEEIDQVWEKYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVY3</accession>
    <name>A0A0D1YVY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Opsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239647.1">
        <property type="nucleotide sequence ID" value="XM_016374371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVY3"/>
    <dbReference type="GeneID" id="27327086"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00003"/>
    <dbReference type="HOGENOM" id="CLU_054785_2_0_1"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31891" checksum="376FD0C114A2B169" modified="2015-04-29" version="1">MSASGNPGTDVHSITELRQYLPDSGTNFLWGITGVFLLVFLIVLIFCFTAPESDRVFHYLYVICLLVGAVTYFAQASNYGWVIVGSFDETSSQYSQSQLFFWAKYVYWTVAWPSVSLSLGLLSGLSWVTMLTNLAISWIWVICYLAGAFVEDNYKWGFFGFGTFSWLILTMSTLNEGREAAQRGGIQRDYLLLASWSSLIWVCYPVAYALSDASSTMDTMGGVIFFGILDVLMVPVMSLAFLTLGRGWNFQKLHLAVSAERYNQERNQLNDDSKTSGVGGLQSSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWB0</accession>
    <name>A0A0D1YWB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239762.1">
        <property type="nucleotide sequence ID" value="XM_016374486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWB0"/>
    <dbReference type="GeneID" id="27327201"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00118"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="565" mass="62210" checksum="256DD9CA1A616FA8" modified="2015-04-29" version="1">MDTATTCDSSEQLSRQSSSVEVEETPVPSPETLVTLDSIDDPLSAQNWPLRKKLWTALAYGLCCVSSTFASALLSPATGLISHRFGISDEVATFSTATLFLFGYVAGPFVWAPMSERLGRKIPMCLAMFGFVCFGAASATAKDYQTLCLSRFFQGAMGACPVAITIASFADMFNPFHRAYASTVFALTVFSGPMLASPVGGFTADNHSLGWHWCAWWGVLAGALSLLVALTCASETYLPYLLKQKAVELRHETGNWALHSRLEEIRLPPGELVKSLFKRPCLMMVQEPILMLVSVYTAFVYALLYTFLDAYSVVFVEGYHMNLGVGGLPFFGLVTGLALAAFANILQQRFYVTPRLKRNNGVMVPEWRMPIAMTGALAFPLGLFWFGWTGAYPHSIHWIVPTASGIVTGYGILIIFMSFFTYLVDVYKTNSASAFAAATIIRSGLAAAFPLFATQMFHNLKVQFATTLLALLAVLLAPVPVLFYFYGARIRARSRFALDESGLEVRRSEKVEEEDEEEKVGALRIPTRGSAVHSDRHLKRILSGEDNWMGSIRSVTREEMEIPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWS4</accession>
    <name>A0A0D1YWS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239977.1">
        <property type="nucleotide sequence ID" value="XM_016374701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWS4"/>
    <dbReference type="STRING" id="91928.A0A0D1YWS4"/>
    <dbReference type="GeneID" id="27327418"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00335"/>
    <dbReference type="HOGENOM" id="CLU_011409_12_1_1"/>
    <dbReference type="OrthoDB" id="3145928at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="61903" checksum="A4FB7C9F2C276908" modified="2015-04-29" version="1">MSKYEGGVLVTRSLVMGVYLASPVAKQFRFIQDRPNDPSSSTSILLPEISLVIPGHTEYERRAFNYFLNRAAPIFAGSSDTGFWKDLVPRLAQSHEFVWNMVVCISLLLEHVPYGSLTTVFDAVKPPVITNHQHRLALQFYNKAISDVRVLAERNEMDDSVALLSCVLFATVEFQQRHVKTGRALVERTCRILIQMLSKQRTSPTSLAVQQVVGPFVLRKAVLMATLGTVLPPEWIANVQSSSGLQMALSRLPALNEARLQFHGLVYQCYEVIRVAELVPEDDPTDPGFHRFVSTRTALLESLLNWKTIFHRDWGPSPDAEAEWMHSYISMYWAVCYVSLAGCASRLETTYDQYRGFFVDIVHHAECYLQMVAESPTYQQALSVDPGCMPPLYFCSMKCRDPVIRRRALELMRVAPQPANRWAFITPDRVVEKVILREEDRVELCTSAEMEGFKTVSWPPERRRYAHTSVFNRPWSGGRERLAVQLSRFAPVPNSKRTELVHEYIWLDESDDDLDLRKQIGRTMEGLTQTAHINSADLCEPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXT9</accession>
    <name>A0A0D1YXT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240302.1">
        <property type="nucleotide sequence ID" value="XM_016375026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXT9"/>
    <dbReference type="STRING" id="91928.A0A0D1YXT9"/>
    <dbReference type="GeneID" id="27327744"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00661"/>
    <dbReference type="HOGENOM" id="CLU_026939_1_0_1"/>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053247">
        <property type="entry name" value="GPCR_GPR1/git3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="57"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="497" mass="55074" checksum="7C5246662F5048C3" modified="2015-04-29" version="1">MASSSDLRGLCRPPFFAEVAFPETGGFVSGRFCMPLSGNYTCCLPCPTTDWTYADGFESRTEVANWVNVAAFVLTIYLILSFLVLPVKYTHRHYLSVCLSLAVIFMELAFIIPLAGKPEQCYNEITPNDMHSSGVCAISGAFLLFGGWAVIIWVFCRALALHLQICWEVVPGDKFFYGALAFGWLVPIIGLALTLSLSGVSFRFGDVCHINHKDALQDFWGPLLAFAALAMVLQFITMGYCIHVYIRSLLDDKATTTNSSQAPTYSGSVKTLSARQAFRRVKRVIELQWRGALLVLVIIGEVVFFSVVFVSMDNSTQVNKELITKAQPWLTCLVASQGDKNQCLSKAGELVQSEGVVMAVLIVLGLSGFWCLMFLGRWSMLQGWAELFRSHLKRKNEFVSADARRFSADPRTYEMLSGTGPQLNITSPDRVLSPAPRGGVMSPEPDSKQDYASGARAYVSPVTSYSYPRPPSQHKDWDPRETYARGEAGYDMKTFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YY17</accession>
    <name>A0A0D1YY17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00746</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240387.1">
        <property type="nucleotide sequence ID" value="XM_016375111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YY17"/>
    <dbReference type="GeneID" id="27327829"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00746"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF53">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="59"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="507" mass="56474" checksum="F8E91D1B2303EAD6" modified="2015-04-29" version="1">MASSGPIASVALPTTTLKASEFDHLELDPTKSEGSGISDEVDWTDEDETRIRRKIDRRIVPLVTVLYLLCFLDRANIGNARIQGMAVDLDLVGYRFNWALSVFYIVYLLVEVPSNILLKHVGPKLYIPMLVMGFGFVSMCTAFVKSFNTLCVARAFLGIFEGGTMPGIAFFLSTFYKRRELYFRIGIFISAASIAGAFGGLFATALARIPRWGTNSTPIHTWRNIFFFEGLLTMLVAGVAPFLMPSNPQTCMFLTERERHIAHERLIREHRADPHERVRLRHIRAAIFNINNNIAALGFFMINVTVQGLSIFLPTILKDLGWTSTKAQLYSVPPYVAACLVAIAIAYISDKTRRRGVYLALFTVPPIIGFSLLRWNTNPSIRYMAIYFITTGAFPGGPGFMSWGINNSAGPATRAVATAYIVSVGTGGGVLATWTYLVRDGPRYPIGHSINLGAQVIVLALATFGILYNLRENRVRAAGKRDHRLEGLTEQEKRELGHHHPEFRYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z035</accession>
    <name>A0A0D1Z035_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_01500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241137.1">
        <property type="nucleotide sequence ID" value="XM_016375861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z035"/>
    <dbReference type="STRING" id="91928.A0A0D1Z035"/>
    <dbReference type="GeneID" id="27328583"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01500"/>
    <dbReference type="HOGENOM" id="CLU_005943_1_0_1"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="8">
        <location>
            <begin position="42"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="7">
        <location>
            <begin position="550"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="957"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1050" mass="115951" checksum="F6A02AB502C3C47E" modified="2015-04-29" version="1">MALSDARDYVLVVENNKQEAAEIAKSAARKLESRETTLIEVVQSLGEYINDDDEKIRGRAVSFLVAVISSLPPKYLSRQQIQVLCQFLCDRIEDGGAINGLSELQSLDRFTNDMAQTVMRAIFEHFSDLQSLNQAGRYKVLQLVNELLEHHRKAIRDMGEESLTGIVDLVAGEKDPRNLMLIFSMLRVLMMEWDISKHVEVMFDSVYAYFPITFRPPPNDPYGITAQDLKDRLRDCLASTGALAPHTFPNMLDRLDSTSNTVKKDVLQTLVACSKHYDASTMSQYSITLWDAVKFEVLQAQEPELAAEALKVLGGIASCLSTAPTHNTSSSPLLQYLKPVNKECLEHLQEPASRQAKASGDIVKAVASASVQSFEIVIKAIGPFLFTLYQSAQGLVQQRAVLEVANQIFEASIEVYGSWTKPSQKNPEGRENPIGELKDKFVAVYSQALMGTVKEEVSFRLTAANGLLLVSKMNSMLADDEIGLFVQYFDDIVLNEESYGRDELKKKAVNALAEISQFKPGLISDITYPAFLARLPDSEEDVMTSDYNSVLEGLAEISIERELLRTLMRRLLTKLDSLFNSGGRASYPYTCAILATILYVLDRAVSAAKTDLSDYYERVVVNLSRTASQTTTGPLASEIVLDLLGRIINLIIRNSTAEQISRAAANVYLLYRGSLPSESPSSLLQPPSVALLSTWILAALPKSIQSPLLDKGRLPHVLENIIQFAMTTSNRAVTQSCLLQVALFVNKHFDSASLESVDELLARTLLALKDHPMDESNASDFNIRLSFFLTKALVLRLAPRTNFYLTNLVELLEQHQYPGEVSRKAAMGFVTILSPDDVLSKQNGAQIRLLAPQRVFQILVPLISDKFRNSQSPTEKENYLVALSGVLSNVPSEIVMPELPTLLPLLLQSLDLTDQMVKVATLETCAVVISNNPSALEESGHIPALVKRLIGVAASQKSDSGTKPAKAGATPGTQMNLPNTRRLATRCLTLMPKYITGGVSGANPLIGLKREVLYGLSRVLDDTKRDVRKEAVDARAAWLRNVDDINEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0M1</accession>
    <name>A0A0D1Z0M1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_01736</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241372.1">
        <property type="nucleotide sequence ID" value="XM_016376096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0M1"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0M1"/>
    <dbReference type="GeneID" id="27328819"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01736"/>
    <dbReference type="HOGENOM" id="CLU_007265_0_0_1"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="49"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW21156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="440" mass="48486" checksum="F5022FE482532182" modified="2015-04-29" version="1">MAFSRSVTSFLRTSRHVVTPARGVNPVNRVWGHDRFGARTYAAVFERNKPHVNIGTIGHVDHGKTTLTAAITKRQADKGLANFLEYGAIDKAPEERKRGITIATAHIEYQTDARHYSHVDCPGHADYIKNMITGAALMDGAVMVVAAGDGQMPQTREHLLLARQVGVQKIVVFVNKCDTVEDPEMLELVEMEMRELLAKYDFEGEETPIIFGSALCALEGTKPELGVQKIDELLNAVDTWIPTPVRDTEKPFMMSVEEVFSISGRGTVASGRVMRGVLKRDSEVEIIGGGDQVIKTKVTDIETFKKSCEESRAGDNSGLLLRGVKREDIRRGMVVAVPGTVKAVQEVLVSMYVLTEEEGGRKTGFSSAYRPQLYVRTADEAAELAWPEGTEDTSRMIMPGDNVEVVLKTNHPCVMEIGERFNLREGGRTVATGLVTRIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0Q9</accession>
    <name>A0A0D1Z0Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar pre-ribosomal-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241422.1">
        <property type="nucleotide sequence ID" value="XM_016376146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0Q9"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0Q9"/>
    <dbReference type="GeneID" id="27328869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01786"/>
    <dbReference type="HOGENOM" id="CLU_009575_0_0_1"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="1">
        <location>
            <begin position="93"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="3">
        <location>
            <begin position="621"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="2">
        <location>
            <begin position="882"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1153" mass="128693" checksum="2400E53C9444630E" modified="2015-04-29" version="1">MTSLDGGARKRRRLDDSIPANTTLITSASQLKSLFSFSKESSSDINKAVESFTQFLSSVSGDKKSGDGERQLKILKTYCDDQSSSSHDQVDFPDLLAIWSNASQSNDDAAFSAVLVALTQFFQAVSGNVDFREFGLSLCHSLLKRDQLRLFDRGLSSPRSKDHIISHCLQLLTEVISFDAGALASNVFGRRDLLYRCLDGILNQPKLGEQRLKAHAAAVEFLLANLKFLDATSKGELITQGKTLHAAFRTLPDQSPDIIIKTLHTLEKSVLGDASLSKQLKIRCFNSGNLSALSKLYDFDHFESEESTDRSLAVREALQHLLLQVCATPKGVMLPHTGWYPLGLNPDALRVDSDTIDLGLDSPYYSDDYADKVPVKNNSLATFIQTLRPEKDILQAQLIVSIFAAGPELIADYFTKKRRFLVPPADDPLWRGQFAFLFSVIQLPVPRNCGWHENPPASPPPLSVVIESILPRPFDRATVTKCLHSDEDVLVLSAARLLTVSLEKLDSVLTLFEQVHPGFRLWTQASSKLISLFIERVPQLQDAITGLQRLAKEKEQIRALVLECIATYHRVIPFLAAGIKFDIGPIFIQDLQRLETDDLDADTEEFLEEQLPRLLQIAEISPATKWFHKPNAETLSLMARVLKYCVSKPDNTFTKRAIPIIKPLLRIKGVLSRNTQSLEALLASLASTKKWQCGPTTYQFLDNCMTRTMQRPVKYLDQVEQEQRMASDSKEVSLVACCISEQWPFVVKRGDKKETKNIAEWIARLFSALDAAGENYRIMAVLKQAMLESARDNTKAREYLEAAFEKQRKKPATLPETLSEDVQVGTSELVADNRTPAPSQEVHTVDLLESCPPLPRIPTSISGLDRWTKPDFETEIQSGRLADLLRCLVNPEAEIRLQAFHTIQTVMHAVEQSAYPEKTQLYLLLGEVSETMRACGFGPTNTAPPSIVAELAAHLLPVIADPTSPYYRKTNRFLLLAPSWTTTRLLPYWLSATFLAEPEADDTDVGNQNAQALEIEHLLDLLVASLRTEVDLDLFRREHVFTRLMSHFLSSTCSKSARTKILHVLHRAACISGGSDTLITRTGAREWLAIAAEVRDHGGHGSTAGKVDLDIRSLVGAIAGEIEETCNRDVIERWEADRPLFRVEREKEKEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0U4</accession>
    <name>A0A0D1Z0U4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241472.1">
        <property type="nucleotide sequence ID" value="XM_016376196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0U4"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0U4"/>
    <dbReference type="GeneID" id="27328919"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01836"/>
    <dbReference type="HOGENOM" id="CLU_030044_0_1_1"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="420" mass="45994" checksum="A357A04596390281" modified="2015-04-29" version="1">MDRKPKGFGYVEFATLDGLKAALDLSGSNLAGRSVRISVAEPPKERQDTRDFSDWSRKGPLPDLPNTQRRVSERPGGFGGRNFDNSSDAGSERGPRRAFAEGDGKVRDFSNWERKGPLSPVSPAPTSLREGGRQGSKEGGFRRNSPAWGEGRSQDGSRPPRREYTERPPPERTPTASEMDNQWRARMRPDAPAKAPTPEASEPSSPAPAAAAVPATRPKLNLAKRTVSEAEPVTSPAPASDSKASPFGAARPVDTAAKEKEVEEKRQLAIRQRREADEKAKAEKAEERRLAKEKAEVEKSKESTSKDTNEAAAPKENGEENSQQPTPKYDILRRADSGTNDMVADDENEQGDDSRPVDDKAVKPKEVVQNPPSRANGSWRNKPVEGSTTAELEEEGWSTVSKPSKQRNNRRNYPPRAIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0Y7</accession>
    <name>A0A0D1Z0Y7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241532.1">
        <property type="nucleotide sequence ID" value="XM_016376256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0Y7"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0Y7"/>
    <dbReference type="GeneID" id="27328979"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01896"/>
    <dbReference type="HOGENOM" id="CLU_000288_126_2_1"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="689" mass="75083" checksum="1A06CFF0614FAD47" modified="2015-04-29" version="1">MAQATSHPLPPTPPPPIYSPPLRIGSPQIIEPVGERATGLPRSVSAQSKETGNPAISMSTVDERPPSASAAPTNLQIHPPETALSKSTDPMAPKRTLTPQPSQQQDPNRLSPTPQAMIRRRPVDGDSVTDHRRVSSENFMSKDGNIELTPFQKRSARHASTSALETEPPSGSFEPLRYHHQLTDPEMNSLDKRASQLTINTDGSGQLDGNRNSTYGRNLQRPDSGFSSTSDFRGRSLSPNLSPGRPVSRGSRSPDTRPVSYVDLLNVPYPQPAPSGAEHLFNLGLRNVVGTNANLLSTKKTLDMYLANVKKTNDSAVQYEFAVFMISAAQEQGLEADAQSEAATSEKSHQSVRNDMLKEAKHILQRLADRSYPFAQYYLADGYASGLFNNGKEDWDRAFPLFLAASKHGHAEAGYRTALCYEFGWGCRVDAAKAVQFYQHAASKNHPGAMLRLGRACLTGDMGLTKRYREGVRWLMRGAESADYQYNQAPYDLGCLHETGYGPDVFKDESYAAQLYTKAADLGHVDANYRLGQAYELGQLKCPQDPALSIHFYTGAAERGHAESQMALCAWYMVGVPNVLEKDEAEAYEWAKKAAAQGLPKAEYTVGYFTETGIGCRRDPLEANVWYVRAAEHGDERAKHRIAAIKAAGAGADPMTAAAAGKKGLLTDSKSSGNIGSNDGGKKKKFGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0Z5</accession>
    <name>A0A0D1Z0Z5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241542.1">
        <property type="nucleotide sequence ID" value="XM_016376266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0Z5"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0Z5"/>
    <dbReference type="GeneID" id="27328989"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01906"/>
    <dbReference type="HOGENOM" id="CLU_031409_1_0_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="232"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW21326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="415" mass="45675" checksum="017098F592329A4A" modified="2015-04-29" version="1">MATTTTSPISSPTASPTGSPGSGGNGPSSPLLFFVALGFGVVFTNLWIIVGVKYCFRYNQRNRQRMNGEDPDGVDLGAMPRQHRRRREKKLMSMDEVNEKFPLIKYKTWRSNRADEGLPTAGGINNASRPASIHNQPRESKDAKESTELAPTHTISTIEEEKPQDQHGTAEVVGEKSRADTRPATPTRPKSAQSTAAESPIQKVTSNYEDEDDEQIQTAVPAEQLPDPGDACAICIDTIEDDDDIRGLHCGHAFHASCVDPWLTSRRACCPLCKADYYVPKPRPEGPNGEGLNRTGTNSEIQPPPGTFTLAHNGRGARRPAMVIPGRFMSIVYHDRDRHGFPVVVRAERRGPQDQNQQRDMDRDFQRSNPPQSTSWRSRIPGFRILGRGRAAAPTQIAPAHSDTQPTPSQLEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z1S0</accession>
    <name>A0A0D1Z1S0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241812.1">
        <property type="nucleotide sequence ID" value="XM_016376536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z1S0"/>
    <dbReference type="STRING" id="91928.A0A0D1Z1S0"/>
    <dbReference type="GeneID" id="27329259"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02176"/>
    <dbReference type="HOGENOM" id="CLU_061288_5_1_1"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="205" mass="22780" checksum="EFC28144FC1A0FE4" modified="2015-04-29" version="1">MPQRKTPAKGKASASRGSTSASAPTKSRRSKLAKENEITAEEEFEIKEAWNLFRVDDVEEYEDEKEGVIPTSKVKDALRAQGLAPKSQTEMQEFIETLDPDSSGYVTYPHFLALCALQLKSKTDEAKDEEVQTAFDLFHPGQNPTNHEQVIRLQDLRIVAKTLKEDVSDDILKAMILEANGGQGIGKGVNIEDFRAVMTRAGVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAM2</accession>
    <name>A0A0D1ZAM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230258.1">
        <property type="nucleotide sequence ID" value="XM_016386126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAM2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAM2"/>
    <dbReference type="GeneID" id="27338901"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11818"/>
    <dbReference type="HOGENOM" id="CLU_010119_10_0_1"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="133"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="370" mass="42543" checksum="8FBF213CB7CA5562" modified="2015-04-29" version="1">MISKTLPEVDHFVPVEPTKEKLDYADLDILDFSLYNDTSAAKNALAEQVHQAMTSHGFFVIINHGISEENIERMVDIGHTILSRTPQEEKERLKADLKGKGEYPGFKPRGEWKTLGGTPDRIEQFNVVRDMTTHEQPKAFEPYREEVQEFIATVHKDILGKILRLFAISLEIRDEEFFVKAHSYDKHDESWFRWMEYYDLPAQGGADGKQLWLSGHQDLTSLSLLFSQPMATLQVRDYHDEAQWKFVPHIPGAIIVNAGEPMMWWTGNYYKAAVHRVVEPPADQRNHDRSSVFYFVVPNDEVVINTLLEESLLLRRHGVKKWFKDADAPTSSEWVHNRIKANLQKHVAANAGEGKTSVQKIGTVTTTWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZB79</accession>
    <name>A0A0D1ZB79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230498.1">
        <property type="nucleotide sequence ID" value="XM_016385554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZB79"/>
    <dbReference type="GeneID" id="27338327"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11244"/>
    <dbReference type="HOGENOM" id="CLU_034751_0_0_1"/>
    <dbReference type="OrthoDB" id="5372703at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="289"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="438" mass="49041" checksum="FB234697775E5403" modified="2015-04-29" version="1">MSNPPRESRPRRARKNRLQPQTGSGCRRSGRLQKKPPVSYAQNAQPNRTKRTHSVEPIVKSSTPPPSIHSLTEENLRLLNEQEMSKRKKTGEETMTNTKRTMTRSKSAPSTNGGYRIHRLKAVNILFDGTIPEHLQAAIDDIVRVKAPSEERRAVIRNAAERFYHSCRGISNDRSMEGDFVGVCRDALRDLLRPGIFIRQEAHWRCEFKPGISEGNPIFRVDEGTPAIKTPCPDITVGIGEETFLETLSSPGLGLSKTQARNFVRRLETEYDSVGPDGERLGLTILGSGRVFFPIVTVEAKAYLTGKQVSEAQNEAAVSGASALNFQLRLTEMAKSSAAEFDDKQYKCPLFFSICTEGPYHELWVHYTFVEEGQRMFDMKLVKICNVMLKETVEDFFFAVDGVLSWGAGAFRQSVVDRMRLVAIKKTLDKGGETNPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZE54</accession>
    <name>A0A0D1ZE54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231508.1">
        <property type="nucleotide sequence ID" value="XM_016384906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZE54"/>
    <dbReference type="GeneID" id="27337675"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10592"/>
    <dbReference type="HOGENOM" id="CLU_126083_0_0_1"/>
    <dbReference type="OrthoDB" id="4147798at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="129" mass="14941" checksum="063513BCA83ECC17" modified="2015-04-29" version="1">MAHKHNRRRIRPRNRNNILQLTWDITEYTPSSLQSSATYPSTFPRPTPTQPTQPALPLTLRNSGASLTSKNWHNRYVAWQNRDMAQKREAIKLEDEQIKLFGGEPGDDVALCYKMLEVFAGMKWIDTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZG14</accession>
    <name>A0A0D1ZG14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232133.1">
        <property type="nucleotide sequence ID" value="XM_016383510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZG14"/>
    <dbReference type="STRING" id="91928.A0A0D1ZG14"/>
    <dbReference type="GeneID" id="27336273"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09190"/>
    <dbReference type="HOGENOM" id="CLU_735651_0_0_1"/>
    <dbReference type="OrthoDB" id="4145134at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="102"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="381" mass="42602" checksum="25F668893C18187E" modified="2015-04-29" version="1">MPLSRSSSISLTLNLHGRRTSSSTKSSVSSPGLDFSTPFGSPTYRTTTLEPNHIIVEDEQMDDERWSRLAFSLGIPFRDSYCTSPVSQKFAQQVSSRPSVSSKEVIELFSPLLASIAKDHDLMKYRNHHQFNREGVPDEIPDVEEDVVWKMQLPTPKPAFTLGYAASAFTYDEVELQQGVVPSSRNKPTRLHKLSQPVPDVYWPFFVVEAQGESMNAARNACAGSAATCNNALMIFAGVAKQPQRYYRDTGFLWNLNKAARSFSLAINGKTACLNTHNSEGCLPHAMATIRTYRLDDEREVSALASRICSIMVWAEHCRLQAILDLLDDFAGRVKLAKKSMTRPEEPYNSVQLSESNAVSRTRNGAVKNVILERLPHWVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZI81</accession>
    <name>A0A0D1ZI81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232793.1">
        <property type="nucleotide sequence ID" value="XM_016384170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZI81"/>
    <dbReference type="STRING" id="91928.A0A0D1ZI81"/>
    <dbReference type="GeneID" id="27336938"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09855"/>
    <dbReference type="HOGENOM" id="CLU_040078_3_0_1"/>
    <dbReference type="OrthoDB" id="60204at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="179"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="328" mass="35829" checksum="9123F2065E0F5859" modified="2015-04-29" version="1">MSGPGVGYEYPSQAVSWLKRDVLLFAVSIGCTVDELHFIYELHPNFAVFPTYSIILPFKKTTQEVIDFYAAQESNPIPGIPKLDSRRVVDGQRLIQFLKPLPTTSEGRNFELRSKVLGVYDKGKPGTVVETEQTIVDKDTGEVYTRAIGSGFFVGQGGWGGPKGPATVNYPPPKGREGSPDKVSETQLTAESPHLYRLNGDYNPLHATPEPGQKMGFGGAIMHGLFSWNSAAHALLKELGGSDPANIKEYQARFAAPVKPGQKLVTKIWRTGDVKEGGWEEIRFVTEVDGKVVLSNGRALMKCVVDGGGAKNTTREPPPMFLTMFLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIS3</accession>
    <name>A0A0D1ZIS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450 oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_07943</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232973.1">
        <property type="nucleotide sequence ID" value="XM_016382270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIS3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZIS3"/>
    <dbReference type="GeneID" id="27335026"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07943"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF188">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW12757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="59454" checksum="E61141ED7662C216" modified="2015-04-29" version="1">MNLQHDGFSWSHLLRYLSWAAASFLVAQVALFLYRAFTSPLRSVPGPLLARFGRIYYFVRVSLGRWEREDIALHRRYGPVVRVGADLYSIDSPEVIKKVYGIGSKFPKSDWYDAWRHPDVNRLHLFPDRDMKRHAETRRRFQAMYSMSSLVSYEGYVDECAVIFRQKLNQFAETGETIDMAHWLQCYAFDVVGNITYSTRFGFMDEGKDVAGLMKALHDMLKYGTLVGVYASWHPLVFDIFSRLGLGGASGRNYLIQYVQDRLEQRKADNKANALQGISKGHATDAPMDFLEKLMIANQADPEKVTPGHVFLIGMGNIIAGSDTTAVSLSAILYNLLKYPNTMKKLRREIEEHCLNPEISFKESQSMPYLQAVMKEALRICPATGLPLWRVVPEGEGVEICGHYFPPGTTVGINTWCAHYNEDVFGPDAKEFRPERWLEAEKEGGERLKNMEAYYMPFGLGSRTCIGRHISTLEMSKLIPQIVRDFDFELIDPEGWDTENSWFIKPTNFRVQVKVRSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJS4</accession>
    <name>A0A0D1ZJS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233268.1">
        <property type="nucleotide sequence ID" value="XM_016382565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZJS4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZJS4"/>
    <dbReference type="GeneID" id="27335322"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08239"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="95"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="587" mass="64864" checksum="E4374CE4AC64DF46" modified="2015-04-29" version="1">MPSSSSRDYGYNEKGIVEGSMPPHVMDETPIARGVRSHADDGDEENFRRGSVNSAGRKHSVVASLKANYGIATPGDDASVKAGHDSTHRKLKPRHIQLIGIGGTIGTALYVQIGRGLLNGGPGSLFLAFTIWCSFILCVTNCMAEMVTYLPISSPFIRFAGRYVDEAFGVAAGYNFFIFEAMLVPFEIVACNVIIHFWSDIVPAGGIIAIVICCYALINLFAVQWYGESEFWLALGKVLLIVGLIIYTFIVMLGGNPLGDRFGFRYWNDPGSFTELYYGGSLGRFLGFLQCLIQASFTIAGPDYVSMAAGEAENPRHVLPRAFKAVFYRLTTFFMLGSLCVGILVPYNDEELSIAFSTGQPGAAASPYVVSMNRLRIKVLPHIVNAMVLGSAFSAGNSYVYCASRSLFGLALEGKAPKIFTRCTRNGVPIYCVALVLLLSLLSFLQVSSGSAVVLGWFVNLVTASQLINFSVMAFTFIKFKKALEAQGIDRNTLPYKSWWQPFSAYYALVGCFIMTFVGGYTVFLPGFWDVPTFFFSYTMIGVFPVLFLGWKFVKKTKWLKPEEVDLRKDMDEIEEYERNYTPKPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZL90</accession>
    <name>A0A0D1ZL90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor eIF4E3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233793.1">
        <property type="nucleotide sequence ID" value="XM_016383090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZL90"/>
    <dbReference type="STRING" id="91928.A0A0D1ZL90"/>
    <dbReference type="GeneID" id="27335849"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08766"/>
    <dbReference type="HOGENOM" id="CLU_043552_0_0_1"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000015">
        <property type="entry name" value="Translation initiation factor eIF4E3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37172" checksum="13422330FD5E9F12" modified="2015-04-29" version="1">MYADRRFSSGKLSLSMRDHEGKDGSRVDSPRSYTNRRFGDTSSHGKSNPFNALSPSATKSPSASASSAFGLGSGAFASFGSAKTPKTPGTGSGTGFDFTSRDKKEKETDTPAEASLAEKFTDGSAESDAQPGHQLRNAWNLFYRPPANKFSDYEKSTQKLATISTVESFWTIYSHLKRPSLLPTVSDYHIFKDGIRPVWEDEANKRGGKWIVRLKKGVADRYWEELLLAIVGDQFMEAGEEVCGAVLSVRSGEDVLSVWTKNDGGRNIKIRETIKRILGFPADTNIVWKSHDDSIAQRSALDEARQQKANAPQSHSGVERRRPTLHDDSDKSGGKAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZMW0</accession>
    <name>A0A0D1ZMW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-keto-steroid reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234378.1">
        <property type="nucleotide sequence ID" value="XM_016381276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZMW0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZMW0"/>
    <dbReference type="GeneID" id="27334026"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06943"/>
    <dbReference type="HOGENOM" id="CLU_029944_0_0_1"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="441"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="51920" checksum="94D34D9F3571C050" modified="2015-04-29" version="1">MSASTRYVLVTGANSGLGLGICCRLVDEFLTSPHTHGRLTIIFTTRSQRKGDETLATLQKHLSHHESYKHTADDRSLTFQPENVELTSLLSVRALSRKLLSSHIPHLDAIVLNAGIGGWSGLNWPLATWTVLTGIRQATTWPTFKLGLVGLVTKPQFPPPSRGQGTREEPVLGEVFCANTFGHYMLVHWLMPLLRACPSESPGKIIWTSSVEAMAHHYNPADHQGLATDAAYEHTKRLTDLLALTAAAAPPARTTSVEEYIMPSESFSLPRRLSSPQQSEPTFLLAHPGICTTTIISLYWIIHECYRLGIYLARWCGSPWANVTSYLGAASVTWLILASQAEIDTKAVEATGDRGGPCKWGSAVDRFGRSSIRVTDVEGWGINGTGKPFKNTWWGGSLGRKSGAVDATEEDVANFKAQGAEVWEKMETLRQDWEARIEDYESEKTRSQEGTGAGAGAGAGAGAGAGAGAGAGAGTAVGNGHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZMY2</accession>
    <name>A0A0D1ZMY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234403.1">
        <property type="nucleotide sequence ID" value="XM_016381301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZMY2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZMY2"/>
    <dbReference type="GeneID" id="27334051"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06968"/>
    <dbReference type="HOGENOM" id="CLU_540819_0_0_1"/>
    <dbReference type="OrthoDB" id="3595619at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="465" mass="51195" checksum="4A509B096EFF7EB5" modified="2015-04-29" version="1">MTLFDCFSSQKTGGAPGSHERPDGVEREMQIMYQQPHLVPPMKLTVFDELPPTPPPQVPSQLSQWVAQGKASLRWSLSVRKHTTRPPVSRPLPLMTTNQLPFRRTGPEFRPIELSIHSPDNRLSDLPRFDRLSFTESGEIKLPPRALLRTQSEHLVPSKISLSPAIVKPASMIEQRRLWSMRPQTSSTVISHSRPPSEHDALHSHPVSMVSLPGLPPPVHGADRLEHPSVAILTPMQEEFSPPATSVTIDGVSLGFPKDVDLQETLARRRHDVPQPEGAPAPIVPTALMRNFSKPTETDSPETYFHPNYHTQKRISHWLAHNTSASMDTTRSSTTTTSSFAEHRRRRAQFYQLSAAPPRDLSMVPVPQKPERTMTQSTVVSNAETDMLSSEYQNRTDTSMTTVESPGPIGLVKSISKTTETVANGVSDVLPSPADAEAVDGADDGRVVIEEIGGPLRSPGVGVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZNL0</accession>
    <name>A0A0D1ZNL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234638.1">
        <property type="nucleotide sequence ID" value="XM_016381536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZNL0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZNL0"/>
    <dbReference type="GeneID" id="27334288"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07205"/>
    <dbReference type="HOGENOM" id="CLU_000288_31_3_1"/>
    <dbReference type="OrthoDB" id="5338352at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="267" mass="29656" checksum="CB925C099E402595" modified="2015-04-29" version="1">MESPDRDHKTFMSAMRCLGTGPSGHVFAIDAHNIMKVTLETAPEYVGDEARRRLQLEKKIYERLGNHDRICEFKYAVDHGHVLEGFMQNLSGLLRLYAQAGRQPPLPLALKWSIQTADACAYIHSKGVIKANLNCHTLFMDNQGNIKLYDFTGSSIDGSMPLERPDPGFVRPGADATRADVQDNLFALGSIMYQITTGVEPSWNSNHSAPHHFHELSRLPLASVITKCWLGQYRSAAEVVKELNEVQDAEISLPKQCPASHVTGTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZNN9</accession>
    <name>A0A0D1ZNN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_07220</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234653.1">
        <property type="nucleotide sequence ID" value="XM_016381551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZNN9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZNN9"/>
    <dbReference type="GeneID" id="27334303"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07220"/>
    <dbReference type="HOGENOM" id="CLU_141397_3_2_1"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW14437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="64" mass="7443" checksum="4CE84A84C7A11160" modified="2015-04-29" version="1">MYSKLVQRCFDHCVNDFTTKSLISREESCVMKCVDKYMRSNERIGERFQEQNAAMMQAGNIGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZP23</accession>
    <name>A0A0D1ZP23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_07306</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234738.1">
        <property type="nucleotide sequence ID" value="XM_016381636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZP23"/>
    <dbReference type="GeneID" id="27334389"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07306"/>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="43"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="144"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="244"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW14522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="336" mass="36486" checksum="3AFA26BF7A293005" modified="2015-04-29" version="1">MSSTANRVKDGARSAAAKVEEVASEAVHNPVQAKNDFLHTPVVRAALPFVNGGLSGMFATACIQPIDMVKVRLQLAGEGIRTGPKPTAFGVAKDIIAQGKALDLYTGLSAGLLRQAVYTTARLGFFDTFQNMMQARAEKNGTKIGFLERGAAGLTAGGLAAMVGNPADLALIRMQSDGLKPKEQRANYRSVFDALLRIAKTEGIGAWWAGAYPTVIRAMALNFGQLTFFAESKAQLKHHAPNWSEGTRTLSASAIAGFFASFFSLPFDFIKTRLQKQQRGPDGKLPYNGLFDCAKKVVRDEGWLRFYRGFPTYYVRIAPHAMITLIVADYLKLITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZR05</accession>
    <name>A0A0D1ZR05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05292</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235463.1">
        <property type="nucleotide sequence ID" value="XM_016379636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZR05"/>
    <dbReference type="STRING" id="91928.A0A0D1ZR05"/>
    <dbReference type="GeneID" id="27332375"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05292"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW15247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="59761" checksum="F641B7B22CC332F2" modified="2015-04-29" version="1">MDPVSTRYALYLVVFLFIFVLLYNFSSRTYNLPKGPPGLPFFGNIFDLGDGPVHFKLTKWASQYGDFFSYKIGRTPYIVLSSPEAINDLFVKRGQKYSSRPKASSQAKLITQEARIVNMPYGENWREHRRVIHSLLGMQTAKLFIPFQEYESRRTLKNLLEEPKEFWEEVSRFSGSITFSLLLSCRFEKPDAVIPQSIGKRMQLFFANIRPGAWLVDWIPILDYLPDALAPWRKQALAVRNQIMPFFLVFHEQMKERVKNGTAPDCFVTRLLTDKTKHFDEVEYSHLIAEMITAGTETTATTLQWFFKAAVLNPDAIVRAQDEIDKVVGADRLPSWEDQPKLPYTTALIQELHRWATATPMAFLHSTSEDDVYREKNIPKGAVIIANAYAIHQSPRYFPQPDKLIPERYLDPKDPRAKPELNLAGPHFAFSAGRRECPGRHVADASLFIMISRILWAFDIRPAKKLPGPGYSAAFPVFGPAPFECLIEPRSNAAAQIILEHAVINRPKDLEDDSIYDTLIGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZSE0</accession>
    <name>A0A0D1ZSE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cellular morphogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235963.1">
        <property type="nucleotide sequence ID" value="XM_016380136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZSE0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZSE0"/>
    <dbReference type="GeneID" id="27332880"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05797"/>
    <dbReference type="HOGENOM" id="CLU_005863_0_0_1"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237877" description="Cellular morphogenesis protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="4">
        <location>
            <begin position="218"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="5">
        <location>
            <begin position="377"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="3">
        <location>
            <begin position="889"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1216" mass="127256" checksum="898B1CFD725536BB" modified="2015-04-29" version="1">MHLLSRFGPRATAALLLLSTQGACQSVSSPNLDLDSLGQVTLAGNFDAIQVYSGQQGGLDSNGSQSVLSQLPGGAFKILSSTDASIEAVCPLVLQDGSLSGVVVGGNFTSIGGVAARSAAVLNTTTLEVNPLDGIQGTVSALYCDPDNGTVYLGGAFEAANSSNAIAWKDGNWSTLPFAGFDAPVASITKAPNGHIVFGGSFTGLGNVTTTNSLNNRSSQVINLGSASISSEGNSTQAGVGDPRNVVCPSNSSTADTTFLLADNTPGSWRADFGFGFQPTKLRLWNVDQDGRGTKTWRFTAHPINGIMNFTFIDPETGNREHCDASCPLALNTSQPFQDFEFVNLVGMNSFTINITDWYGDGGGLAGIEIFQGDIISYAIEGFNEPQCLTDGLRSQSTATGPWYATPSRQSVANYLTVVVGPTTVNSTSIVFEPEVQASGNYSVVVYTPGCQQDSSCSARAIVNISGTLTSDGGQTFSTLIYQTNDFDKYDQVYQGHIDASTSSFRPAITLTPSGLQNDQLIVASRVKFGFISSTGGLNGLFDYNPDSPFVSNDFSQSAINNAGTMLHPNAHMSALTTRDDTIYVGGQFSDDSFQNIMAFHNNNVTSLPGGGLNAAVSAMYSLDDFLYVGGNFTNTNQSSVDGLNNVAAYQHSKGAWAPLSAGLNGPVQAVVPMLLNVSGSNAETVIAFSGSFDQIQASGSTPSAPANGLAIWVPSQQAWLQNLDIQKQSLQGQLFAANFLPNNTWIGAGTIHSLGLAMSGAAGIRSASGEISLQQLPINIDSSSSQTTTRKRAITSSQNVDGVTSIAYYDGNGQNVTVFGGRFSATATNGSTIENLMFLNSSDNNSVSGPPAGLDSNSSIATLLVSGNLLFVGGRLSARFDDDNVQGLVLLDMTTADYRTIQPASLRGPNVLVNAIVSKTGTSAIYVGGSFDQTSQGLSCPSVCMYDTATNQWNTVGTELAGTVMSLFWTSSSTLLATGNLTVAGNQTSLASYNTKEQVWTATTPPGVPGVVTAFCPATDNADHMWIAGIANNGSTFLIELDGDNTRPVPNAFGSGTTIEGLTIMPLSKSHGSSQYLDDDQALLVSGQLNLTNFGTAAAALFNGTTMTPLILASKSNGDPGSIRQVFTYENNNLKSSRRFGHSKGIAVLVALCAALGTIFLIILIGIILNRIQRRRAGYKTVPSVPYADKNSNIHRVPPEALFGSMGNKPTVPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTT1</accession>
    <name>A0A0D1ZTT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236408.1">
        <property type="nucleotide sequence ID" value="XM_016380581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZTT1"/>
    <dbReference type="GeneID" id="27333326"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06243"/>
    <dbReference type="HOGENOM" id="CLU_076390_0_0_1"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22340" checksum="1F39736634CC0289" modified="2015-04-29" version="1">MGTKRSSDDRPVGADEPDNKKRKGFSVGPANLPDGTYRRKTQKIKRDLIQKAKVKKAYAKVKAQEEAANPVSSTHIEDEEAHDGPLDAEPASLELHPDRQAMVEAADSRDARDDQGHSSRNHPRQRRPKQSRFKKELELASQHRANIEAKQRARELRDKERRAMIKAKKPGKNGKIKLGRQGTVLLSRIQRMAAEGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZU40</accession>
    <name>A0A0D1ZU40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PV08_06363</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236528.1">
        <property type="nucleotide sequence ID" value="XM_016380701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZU40"/>
    <dbReference type="STRING" id="91928.A0A0D1ZU40"/>
    <dbReference type="GeneID" id="27333446"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06363"/>
    <dbReference type="HOGENOM" id="CLU_024516_1_1_1"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="21">
        <location>
            <begin position="62"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KIW16312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="556" mass="60936" checksum="19AA46FBC91D59DB" modified="2015-04-29" version="1">MADTPAQAQQAGHMSTEIATKKDEVSTVLNELDESKDLSRESSEPADSDGRPEASLTWKIVAILLVSAIGFGAHWSSGITGAMKSTLKKELHINNTQFALLEASEDFMVTALILFSGLVTDRIGGAGNYFPYQESLERALVVPGWLTGLVGAIMYGNVIYSLGSILIAAAAQVRSYRFMIAGRIIAAFGDIATQVAQYKIFSSWFPPSSGFASTLGLELGIGKIGSFVGKSSANVIAKNTGNFAWVFWVAVFMNLFTNFMTVVFYQFNKIATKRFASVSDPATGEKLTEKNKKFEIKKVLELPWIFWCIMIFSFFQTSTAIVFTQNATELVEQRFGTDSVTAGWYSSTVQYAGFFLVPIIGIFIDLFGNRVSLMVLCGTGTFLAMALVAYSNTTSGNAAAFGIFAFAYTFGPTVIIDGIRTSMWNQSVFGSAYAVKIAMNNSVNIIIRVVTGVIQDRDNNSYDKVSIFYSAWAAASAAVSIVLVILSLRSIDLRRLQWTRKQRIAKGAIINERNRRFHDEEGEKNRRISKMCFGSLIVLILGAWSAYFWGVATGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYK2</accession>
    <name>A0A0D1ZYK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237958.1">
        <property type="nucleotide sequence ID" value="XM_016379281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYK2"/>
    <dbReference type="GeneID" id="27332020"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04937"/>
    <dbReference type="HOGENOM" id="CLU_915370_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253202" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="32418" checksum="D83D64980815E6F2" modified="2015-04-29" version="1">MELPFLLSLTLMISSLTVLGQYGKWSDLPTCALGCLDRSTTTMEEYWPNGYLPVICGLSSPDHKAFKLALRSCFYESKAEGCNGTSGLTSLVDDTINLFCNLSSKDSTLFDSANLNGTMTTTRTSVTPDSSVLSAQWIPTLTADKDVSQDGTPVPPSPSDSSFATAAATPTADSVETSNLPSIAVSTRFRNLSSPPSTYTSRPPLPTLPGNELNSSTEVEVSTIYSTHVVTFSGSTSTSLTTSMYPESSLRTTTVVVTASSASVSSAGTASSGKMVMRSDMWYLFESFIGLVIYVTMRGEWYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYY2</accession>
    <name>A0A0D1ZYY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238088.1">
        <property type="nucleotide sequence ID" value="XM_016379411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYY2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZYY2"/>
    <dbReference type="GeneID" id="27332150"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05067"/>
    <dbReference type="HOGENOM" id="CLU_070631_2_1_1"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238113" description="Sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="9">
        <location>
            <begin position="75"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW17872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="219" mass="24116" checksum="F27D5C180465EDE7" modified="2015-04-29" version="1">MPRGPPPFLVLIAAVSLFVWYVVWTAGPPRDMTAFSYSDKIQEKIKPKLSQHFAPMADDTEVVIHGEHVMGKLGNETLKAELGRAAWKVLHTTMARFPDKPTQDEQDALKNYLFLFARLYPCGECAEHFQKILKKYPPQTSSRSSAAAWACFVHNLVNERKGKPIFDCANIGDFYDCGCGDDEKDAISAAGAKSSSVAAGKPSRHESVEIEVEGPTRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0D1</accession>
    <name>A0A0D2A0D1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_02730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238658.1">
        <property type="nucleotide sequence ID" value="XM_016377088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0D1"/>
    <dbReference type="STRING" id="91928.A0A0D2A0D1"/>
    <dbReference type="GeneID" id="27329813"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02730"/>
    <dbReference type="HOGENOM" id="CLU_045845_0_0_1"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52556" checksum="95E92092F1632FF5" modified="2015-04-29" version="1">MWTYGNFDTVMATPELCEDFNYEGSSNPPAVDQSAFASSSTSQMPLGDDYNIGGIAWDPASKPDVYDGLLPEMMSPSPITLDSNEDEEVLRDIQQFFDKAWFIFPLLSYESIRSQLNTRPASKANPQFRCLLLTIRLANATVEHRMTSAHSATLLGLIRRIEICRHDYDFAEPPTLDDVVTSTVLFVAYNIMEKHVRAFLFLDEAISLLEEVNPVGEAEFLRKQLIQQVLYNTEAASVAIYAHGRRGRRMKKPVKLIDKLPTSSSTDGSVTQFDRLAFQLLNKLSQIHLANDAEELQTTNTNHLEGDLKTLFDVSLQQHQFCRIQAADVAVTHQWQLSQKAVLGRARGLPVSRPSLQEVEDLGLTAMAWVCSLKEGELRIVGLGKLAGLARAIHTIAGNNCCDYAIAGLVGAVMKEDHDHQFTSELAEVIMPRLSVPLPIEGPLQNDYANNRLRAHQYPADGQIWPLNDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0F0</accession>
    <name>A0A0D2A0F0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238673.1">
        <property type="nucleotide sequence ID" value="XM_016377103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0F0"/>
    <dbReference type="GeneID" id="27329828"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02745"/>
    <dbReference type="HOGENOM" id="CLU_036824_1_0_1"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="171"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="586" mass="65096" checksum="789908E1D3AA7CAD" modified="2015-04-29" version="1">MRWATPSLLILPGIQLRTIIPVRNAKSRSQKSNSVCEYRKVADPPPTKLESEITTIKDRLGNIEHLLAAQKRPAAIHRDVDSLLSPHATSTSTPAPIVALLEGAQSQSPCLSDSPGFPVMVIRNKSFMHLVGVEIDLAAHLAKLERLAGSKTVGENGRHFLLQQSRAINALNAFFEEIHPWYPILDSQYQVVYAAVMDGDLKPSSESCLALIVAALGSLSSHDVRGKHTMYADMALSMLARIIADCSVLAVEALVYIAVYYCCLCSPLEAFEYNAIASLKAQSLLTVNRCSVSEADSEALRRAFWAILLIESELCVQLELIDTGVWNLDESTMLPKLRDSWSTSPQLPFYAQPDGDHTANLEDIDAYFLAEIAMRRISHRAPSAIRGTSRGELVYAPIVASELNYQLDEWYHHLPSSLKFHRGHQAEMRDHRGLVLFLRTQYYSCMTSIYWPAVYKVIQTGRREDNLHLGCQKFFDAYYDFLLSATVCLQHCTVNKWTLLASIFAFTMAAARAMKEPALADAVPPRLFASLTHAVSSLASSVHCGPSLSYMHNLLKEHLTGLVGFSPEQSSQTSRSTPLMQRPDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7R1</accession>
    <name>A0A0D2A7R1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241043.1">
        <property type="nucleotide sequence ID" value="XM_016375767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A7R1"/>
    <dbReference type="STRING" id="91928.A0A0D2A7R1"/>
    <dbReference type="GeneID" id="27328488"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01405"/>
    <dbReference type="HOGENOM" id="CLU_002392_2_1_1"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="925"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="925"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="990" mass="109147" checksum="8D93684DDF9A1EB9" modified="2015-04-29" version="1">MDIHRCRFVQYPADPIHALAFSHPSNTKEKTPSDLRLALGRGNGDIEIFDPRDGRWVQEAIFKGSKDSIIEQLAWTQDLVLEDEAESPKYSRGPLRLFSTSGANTITEWDIATGSPRRQTEANFGDIWCFAVQPQIENPEKIKGLEGGAHSQLIAAGCANGTIVLFSTEDDDLRYLRPLLTPPVKKPRVVSITWRDRTTVVAGYEDSTIRVIDLRTRTTIRHMSLGKPVDGEHTVVWAVKCLPDGTIISGDSTGELKIWDAKNFSLVQRLKSHTHDIVDLATNVDGNVIFSFGVDRRTVSYRPALTPTGGKKTRWAEISHQRYHRHDVKCAATFESKGLSVLISGGMDCKPVVVPIRKLQTESHRKLSPLPQRCLISASTSARMFVSWWNCEIVVYRVRAQGNLSENIDFDDTTGSSYEILAKLIVQGDEKIQDAQLSPDGQFIIAATLNSVKLFQLRQTHAGGKPCVRTRTIDFPPAVVRLGAKRAGFSPDGKWIYTIRKDNTVALNKLVPPDGSTGRPTINPKTVKLYRASRRSVHSALGGYLQTINHVAMSGDSRVLAVSDVSGAIDAWVLEGHEDLDYIEDNKPGSSSDSSSDSSDDDDDDEDDSPVIHAQKWIRNPSGSQLPQLDSSILALTFRPSPHPSLSAAADGNRGLHATRSTAHPVAHELPTSNEMLVAVTAKHQLVEFDVVSCRLSDWSRRNPSRFLPQAFKSLSPPIVGCFWDCTDRANKGERLWLYGSNWLFMLDVSQDLPQDKGVKAEKICTLGKYNVLDPVLSHLQHRQDGKRQHGVMSEMLGNGGNAHKKQKRTTGGVGRPLSAQQRTSGIGRAMLKYTGPSIEGDDVDVIDLDADLNADGDMDVDDDGDDADALALMRRGEYGDERLESGDTNNAIETTVHKTRRPHWKTYEYSDILGIGVLGPVSSASGADSGAVNAVHGHETENGSGHGPVEKKTERTEENLEVVIVERDVYDMIRESPYGRIDTGQDWDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7U1</accession>
    <name>A0A0D2A7U1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241073.1">
        <property type="nucleotide sequence ID" value="XM_016375797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A7U1"/>
    <dbReference type="STRING" id="91928.A0A0D2A7U1"/>
    <dbReference type="GeneID" id="27328518"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01435"/>
    <dbReference type="HOGENOM" id="CLU_026791_2_0_1"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01503">
        <property type="entry name" value="TREACLE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="235"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="337"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="413"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="485" mass="51287" checksum="178774A5A836E92D" modified="2015-04-29" version="1">MSKSTKSKSAPAAKESKSDVLSKVKGAAVTKPAQTGKSKSKEIAKKVAAKEEKRSKKVPVKEPTPESSSEEEEEDSSESEESDSEESESEVETKPTKKANGVKVAPKDASSDEESSEESDSEESASDESESEAEAPKTNGAAKAAVKAAESSDDSDESSEEEAAPKTNGTKPAEAESEDSDEDSEEDSDESSEDESDEEEEVEKKPAKRKAEDTDSPVAKKTKVETTDADTSKGSNLFVGNLSWNVDEEWLRSEFESFGELSGVRIMTDRQTGRSKGFGYVEFVNAADAAKAQGEKHGADLDGRALNVDFANARPDNGQKQDNRRKSYGDQVSEPSDTLFLGNLSFDCTQEDVTDAFAPHGTVLGIRLPTDRETGAPKGFGYVTFASVEEAQAALEAMQGGYIKSRPVRLDYSQPRQQNDSPARGGFGGRGGGRGGFGGRGGRGGGRGDFGGRGGRGGRGGARGGRGGSYNRGGFGDFSGTKVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7Y1</accession>
    <name>A0A0D2A7Y1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241108.1">
        <property type="nucleotide sequence ID" value="XM_016375832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A7Y1"/>
    <dbReference type="STRING" id="91928.A0A0D2A7Y1"/>
    <dbReference type="GeneID" id="27328554"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01471"/>
    <dbReference type="HOGENOM" id="CLU_1042188_0_0_1"/>
    <dbReference type="OrthoDB" id="4143634at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="267" mass="29101" checksum="2C711660E8EE5C6A" modified="2015-04-29" version="1">MLNARKNTPNADDKKVGFASPAFPPGDEIYEAGESVHNASGDLAIDTERMGKICKKLKEPDLWPKRFAQIIKEQQNNITKKIKEMTAQDLALQEEFDRGFLPLIQEALGGAGASNEASNLATQPIHVAYLGAEGQPYCEAMITLMKQADALIFALDQLSARTPPPSRLSDINMSFEQDKAAAVATIEAGRRVAETAVEDLLADRLQEVRSSTGLTAEEENRGKILLSKGVTSDTPILEPMGWGNVSRDAERALRKLCFAGDIHAKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8N3</accession>
    <name>A0A0D2A8N3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241348.1">
        <property type="nucleotide sequence ID" value="XM_016376072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8N3"/>
    <dbReference type="STRING" id="91928.A0A0D2A8N3"/>
    <dbReference type="GeneID" id="27328795"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01712"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OrthoDB" id="4160219at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="58"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="594" mass="62946" checksum="2F62496FF79C645B" modified="2015-04-29" version="1">MSSNHDPERRPLLSSSNGNATSPGSGSGRGSDPRPINGVDSGVAKEKSNLSRTRGALICLSVWILIFILTNNVSLITTIQSPIAIALKASTEVSWFTSAYLIAVTSITPVAGRLCAIFTPRVYLLASIVVQACGLLITSQARTLGSFLVGRAITGIGSAAVTPVAFILVTELTSPRRRGLFFGCINTGYTSGVACGAIIAGALEPLVGWRAVFWLQIPFALCAALVAFWSIPATPHSPPTSTSPGQESSNTSRPQSEYEKDDSLGKKLSQIDYFGVITIIAAVVLLLYSLSSPSIQITPIVLSLASLVLFVLVEANWAKQPIVPVSVLKSRGNILTGVATIGVMTARWGVLFFTPTYVLTLRGWSQASAGLTLIPTNLGFGSGGLLAGWLHIRRTGSFYMSVLVSFVLFALSMFAVSWISTPSSNIYLYIVVLFFNGFLVGTLLNYSLAHVLHLTVPATHIIVIPLNAMFRSLSGSFGSSISGGLFLRTLVTTLRDEFARRGVTGKEGLIKQLAGTPILVQRLTGVEREVALVGYETGLKTVYLAGGCLAVVMLVVQACVGWTAPDIDKEDDGGNGREGRMGGDVLTPVVSRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASL3</accession>
    <name>A0A0D2ASL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_12051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847504">
        <property type="protein sequence ID" value="KIW09708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229924.1">
        <property type="nucleotide sequence ID" value="XM_016386358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASL3"/>
    <dbReference type="GeneID" id="27339134"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12051"/>
    <dbReference type="HOGENOM" id="CLU_019095_0_2_1"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253887" description="DUF7492 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="2">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="259" mass="27990" checksum="F3CA095633BDF929" modified="2015-04-29" version="1">MTLLAGIGLLLCSLTLVNCHTWIEQLSLVDQDGQPVGDPGFIRGYVPRTTPGFVDGDNTYLLPQAPALTFQDSDLMCKLTQTQGNQSGGSVLMAPQGSSVLLRYLENGHITQPDVPPNKPTSGQVSVYATTQARDDDKFTAIHGQWTADKTGGDQRGLLLTSTPFDDGRCFQFDPTGHSEIATTRSNTFGPGPSITEAPNRWCGTTIELNDETGIPFANGTLLTLYWVWDWPTIVPGNPGTPPAILNETYTSCMEVEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AU09</accession>
    <name>A0A0D2AU09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230171.1">
        <property type="nucleotide sequence ID" value="XM_016386039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AU09"/>
    <dbReference type="GeneID" id="27338814"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11731"/>
    <dbReference type="HOGENOM" id="CLU_963228_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="289" mass="32529" checksum="9BF5A16ABAF0A32D" modified="2015-04-29" version="1">MDDENIADVLGTCKQRLDALLDVLTQLLSSFDKDEDDPFFAPTILGAGAHVEALKISIDRQETLSLRLADTKQALAATQQALAVAEQARTATSHRNRELNEELDRGREELDRVQENLSATMTELARSRLDLAKSNGELNRTAQVSSDKGEGEFPADTQTTGEVWQQRIAELEQRNSELKHEVKNKTEAEREAKESLMASQRKHEQETSKLRETIRRLEQEKSTTLSGSTHEQTDKQMENQLESNPDRSEPTTWDTRASVNLTQISGISLQTAIPSRLPILSRKRTRIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AX14</accession>
    <name>A0A0D2AX14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231464.1">
        <property type="nucleotide sequence ID" value="XM_016384862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AX14"/>
    <dbReference type="STRING" id="91928.A0A0D2AX14"/>
    <dbReference type="GeneID" id="27337631"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10548"/>
    <dbReference type="HOGENOM" id="CLU_011075_0_0_1"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="65"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="719" mass="80122" checksum="D1A5F6A127E321CC" modified="2015-04-29" version="1">MPIPSQVDIFEPQPPDEQLSTTSSVPGHQRHDWNFQHHPDGSYAEVPPRGIPSKKRKRKVPTLQPDKWEPYKARILELHVNNGLPLSEVQRLIEAETGFGANLRQYRTRISQWGYDKNVKPNEMSAIVRKQQHRSLNEPGKAPLRFKIRGNVVEKPKVDRWMQRHGVPQDSLYAPSPEAATPSALSCWTMSESGSPAPSPSSFPGSVPPTQLPSPTDMAPVHHQIPLGPFSTEVINPSRNSFMSQRPPQLLENYKTSTDMSCSVGKWTNQVEAQDGLLTRIHSEQSGLQTSPGITSGVLYKGVRADWTVQRSSPTDNGNWTMDGISDERNDSPTTTDGSETECSNLRPQPPASSARSASALEFVVRAHLYPTPGEDLLCRFDDQICSITCHRERPPEISASLLWSSALRWPALFRGIAAISEFNDSREGTHLRSFAFSQLKLSIHMLFSKVDDMHLEAALATSLVMAQCDGWCGCPGMCSEHIDLPGRRRWPNTAMNMQKQRVREGARGPRPLEFCCSSHVYLDVIRSLIPFRVGKVGYTEILPVNQSDRARFAVDPLMGCTATLFPLISATAALVQLVECRHRYAWPFPGRRPYGNSSSIISLAQDLKNQLEEWSVPFAPDVFQHPEDSDCRIYHSIQMAEAARHATLLNLHQAVPEVPGEPSMVMAGEVLGRLLDAMPESIRTSFREIFPLLAAGALIDAEDIEWLSKRASNHHIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYK0</accession>
    <name>A0A0D2AYK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231681.1">
        <property type="nucleotide sequence ID" value="XM_016385079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYK0"/>
    <dbReference type="STRING" id="91928.A0A0D2AYK0"/>
    <dbReference type="GeneID" id="27337848"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10765"/>
    <dbReference type="HOGENOM" id="CLU_025711_4_3_1"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="240" mass="26030" checksum="573AB6BC678F0850" modified="2015-04-29" version="1">MAGDKILVLGGTGPAGVCVLRELAHRGLPMIVYARSPSKIPSDLASDVLVEVIKGDMNDREALSTAVAKSKAIISLLGPNSMRQPKNTEYADYYRTTISLMEKHGVRRLFALGTTAIYQPEDHSSVSRFLMARLIKLLAGGAYHNFLAIQELFERDQVARDIDWTVFRVGNLSGSAEAEDWKTERGNGAAYAGPVAGSGWTNGITRSTLAKWLVDGVENGAQEWIHQMPAVSELAGDKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYN2</accession>
    <name>A0A0D2AYN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endoplasmic reticulum vesicle protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_10795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231711.1">
        <property type="nucleotide sequence ID" value="XM_016385109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYN2"/>
    <dbReference type="STRING" id="91928.A0A0D2AYN2"/>
    <dbReference type="GeneID" id="27337878"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10795"/>
    <dbReference type="HOGENOM" id="CLU_066963_3_0_1"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249288" evidence="9">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="35"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW11495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="215" mass="24398" checksum="AD17D3E4119A5FA3" modified="2015-04-29" version="1">MKSFLDLAVLLWLLPFSYALKFELPAHSGHSAKNERCIRNFVTKDTLVVVTAIVSGSRGDGQMVNMHIKDAVGNDYGRPKDVAGEKRMAFTSLADTAFDVCFENTLVGRSHVQNPSRHVELDIDIGADARDWSAIQASEKLKPVETELRRIEETVNEIVQELEYLRLREQKLRDTNESTNERVKWFALGTMGMLVGLGAWQVVYLRAYFRSKHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B062</accession>
    <name>A0A0D2B062_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232291.1">
        <property type="nucleotide sequence ID" value="XM_016383668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B062"/>
    <dbReference type="STRING" id="91928.A0A0D2B062"/>
    <dbReference type="GeneID" id="27336432"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09349"/>
    <dbReference type="HOGENOM" id="CLU_029501_2_0_1"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="51"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="249" mass="28169" checksum="8DC8558687B32025" modified="2015-04-29" version="1">MAVQTGQLDYEDKHVHRVYEEIASHFSATRYKPWPVVDWFLRGLPVGSVGLDIGCGNGKYLTVNKDVFVIASDRHAQSPFSRVKDMSDCSTRSKALVDIASQHQPHNALVADTLNLPHPDSRFDFAISIAVIHHLSTKERRIEAISRILQTLKPPSENADSGQALIFVWALEQKSSRRGWDKGDNQDVLVPWVLKPDHGADSESPKTYHRYYHLYHEGELEDDAKTAGARIVKSGYDRDNWWVIIGRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0W2</accession>
    <name>A0A0D2B0W2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232729.1">
        <property type="nucleotide sequence ID" value="XM_016384106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0W2"/>
    <dbReference type="STRING" id="91928.A0A0D2B0W2"/>
    <dbReference type="GeneID" id="27336873"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09790"/>
    <dbReference type="HOGENOM" id="CLU_025462_2_0_1"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="405" mass="46648" checksum="08D1F307D7665826" modified="2015-04-29" version="1">MPDHLPHIMKPSFRWHWRSWEDIKAASTFTLTNYTNFILLIIFVALALRQIRSQQAAIKKSSHEKRFLKADDFPPVEEQQDFDWKTTKPLQYRPFKPKYHLTMALEKLNPTELLVMDDTYADRMAYRRRIIAENGKHVVNVNDDARIRPAVVELYVFLMGTYLPLRFPQVFKLHETEYEQGKTYMLENTVTGSLFPAKPSATTSTTSLLEILGRTVDEDFLFLVPEQGGGDDDPKYVFEAYVLVCPSGFDPTEKIGKRLAAIHTPVPGYSSKLEASMDRFFSKIEVGQYVRRVNWAITTNTDLYSPGHGTNHAHEGDEIEELDEVDIDKTFMRCERQTLHRLPKSKALVFAFHTYLYPIEQIKKEGGGEDLANAIDGLKMGNVPAMHFYKRGAVWGEAVKRYLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B314</accession>
    <name>A0A0D2B314_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233539.1">
        <property type="nucleotide sequence ID" value="XM_016382836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B314"/>
    <dbReference type="STRING" id="91928.A0A0D2B314"/>
    <dbReference type="GeneID" id="27335594"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08511"/>
    <dbReference type="HOGENOM" id="CLU_694446_0_0_1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46072" checksum="5B8F0F7167CCEAD8" modified="2015-04-29" version="1">MFATFKVSKTDIGATKAICLWDDDEEQDPSSYESEAATAISPSPYRAHVPGTPLTFIGLKLPAYTEQTRRGPIPNPTIKATHLDFLVHTFDVIQGLSWADPEYSLVSLGFQDAIHNPCLMYAFAACGAAVLAKGDSRWEAVCLAHHTRSIELVSTALRSNLVLTACDSTWLLAAINALHIFETLRTYDSQPNTFHLTAAVELCTKQIEDGRALTIFQHKVLGEVIFQLVIATMLHDVINWIFRLSYLRLRVPLSGSHLSEARTIVASLERWQPSSPILGSGEDGVRIPAEVISTAGIYRCACLIYAHKLVDCTLSSSDAIIAVYVRSGVDLLANIHASNPRDTSVTIWAVFIIALATGTTEDRIICRRALQYLLSTFGIGCIRGILDLLSYALEDDSTSHYGTAGLDVLFRDDLLGQIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3B8</accession>
    <name>A0A0D2B3B8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08302</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233331.1">
        <property type="nucleotide sequence ID" value="XM_016382628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3B8"/>
    <dbReference type="STRING" id="91928.A0A0D2B3B8"/>
    <dbReference type="GeneID" id="27335385"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08302"/>
    <dbReference type="HOGENOM" id="CLU_045401_1_2_1"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00300">
        <property type="entry name" value="LDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
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            <begin position="16"/>
            <end position="158"/>
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            <begin position="161"/>
            <end position="321"/>
        </location>
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        <location>
            <position position="191"/>
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        <location>
            <begin position="21"/>
            <end position="26"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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            <position position="46"/>
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        <ligand>
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            <begin position="134"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KIW13115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="326" mass="34525" checksum="B622C3E98A4BFAB5" modified="2015-04-29" version="1">MDPPPMDPEVPTSRSRIAILGAGSVGSAIALCLILNPVASEVLLVDPNTAQRDAQVKDLEDATTYHGAVGGGGVRIRAGTHKEAGQCDIVVISAGAKQRHGETRTALLGRNLAILKSATNDMKPFSKHTVVLLVANPVDVLTYFCQKFSGLPQQQVIGSGTFLDTARLRGILAVKLGVDASSVHAYVLGEHGESQMVAWSCATVGAMPLDQCLPPGTDLDRKAIALEAKDKAAKIIEAKGATAYGIGALSAAICKSILFDQRIVRPISHWIEDLGCCLSLPVVLGRKGIVRSLSIPLNKEEQDLLIRSADTLKQLIAEAEDSQQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3F3</accession>
    <name>A0A0D2B3F3_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PV08_08611</name>
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        <name type="scientific">Exophiala spinifera</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
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                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016382936.1"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
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        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="197" mass="21745" checksum="0D7260D09BCE1CEB" modified="2015-04-29" version="1">MSTSAATSGELVSHSHNNNDNSNSNSNRQTGNENNGGGGSSSSNNNNNHGEMGQVGGAVGAGSNHPRLVGPYDTRPPPPTTQHPPQPGGLVFNRGSTRAPALYTSTIRTIVPHVAIRQGHNVADRPYAYECEVCRRRNRKVQDFHRHMRQLEGREGFRLVRPVPQVEMTWYGVDDAGYRYRGPLLRLGQEPLSRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D2B642_9EURO</name>
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        <recommendedName>
            <fullName evidence="7">SEC7 domain-containing protein</fullName>
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                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
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                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CBS 89968</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053328">
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    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="4">
        <location>
            <begin position="489"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="775"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1306"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1341"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="960"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
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        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
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        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
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        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
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        <location>
            <begin position="1065"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1187"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1234"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1345"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1367"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW14165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1380" mass="152590" checksum="8BA78D967BCB3A95" modified="2015-04-29" version="1">MSLRTLLSRPVTAAPHRRHSSIIDDASQEGGLVEGRIRADSMQRLSLGFTRSHEETLNPFMAYEPDPTLSRKEPEQHNGLSAAPSALPKSVSTPTTMTSTLKDQSEQEQGVKIDLEDLPLPKPQRLSVLGFRHASDPQLFTRFRKDEHGVTPSNEPAPPKIITTAPTTQEFDEPAKRPKRKLFLRAPSSFRKGMASKHDVQESLREDDHEDGDKVQSTSSKAGMLRENTSFERLPRRKTDVNPMAPPPYGDETSSSLAIPVTRLSDSSRSDDSSGSHHVYAKTTTTHTISTTTTFFKLKRRKKNKGHLFPLPERFTASDSGRTSASYGREDSTSERKSLSPSRKSTTAVRFEAQSSRQDSAHQSPTHSAVAFTNAPFGSPGPAIIRQDSAAWSTHSGHSTPSVTLGPPRTNGRGRSSTMTSLGRSADKFLDTVPQPGSARTSTSTTGRRSFGDLLNLPHRLRQNSAPPVRNSAGNSPGTPGSKSNSLHIPREEHERVYPKREDGDTPASYLEKLEAAVPRGAMATALCKAADEFSRTCLRKYMRGFSYFGESIDMAIRKMLMEVELPKETQQIDRLLAGFADRYYECNPGIFVSTDEAAFIAFSILLLHSDTHNKNNKRKMQKQDYVKNTQQGPVQISSDILDCFYDNICYTPFIHFEDEVAINTHRLATAPKFKKTLIKTKSTESLRGPVDPYTLILDNKLDSLRPPLKDVMDTEDCYSSTGTAGGPEHVDVHKAFVNSAVLQIVSARSRPDAFLSQATITNPVDAQVGLVSFKVAKVGLLWRKDVKKKKAKRPWQEWGAILTDSKLYFFKDVGWVKKLMGQYDAHAKTGSKSGPLIFKPPLSSFEPDALMSMDDAVALIDSSYKRHKNAFTFIKHGGFEEVFLANSEVEMHDWVGKLNYAATFRTAGVRMRGPVSTNYEGRHLLRNDSDFSSKSGETRHKDKKQDVQAAAWEIMFYRRQLINEKISDFDERLAAAQKELDNLLRNARHLLILLPIQQKTREQLVLAAGRMSAKLKWTRVEVWRTKTHRDTLWKDLEHEGVTAFPAPRTPSSLTPQRATPAKTGLSNLGRSATETSHPTLSPISATSSRPSNLADRVKNSENGSIHTAPSTIDLTTEANLNPSSTDLGLTKSESTHDSKSLIHQISITSSHSRDKEQSAKRTEDTEEQVLRDAGLVGVEGAVLQNKRPDTSESERDRVGTITAPAEGAKNSGVRRSLHRSLREAGHLREGIHHHSPSIHRHKKGRDSGSSIAPTDDGTLSLGSEPGELKRGAGSFILHGKKASVITMSSEWQSMSREDRMKLRTAGQETEGAKDSYLAPDNDGDDAIETASSLMRALDDRYGSPISSRRPSIATSTEQFVDAETGETGHQDQRGARGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B664</accession>
    <name>A0A0D2B664_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234406.1">
        <property type="nucleotide sequence ID" value="XM_016381304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B664"/>
    <dbReference type="GeneID" id="27334054"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06971"/>
    <dbReference type="HOGENOM" id="CLU_066708_0_1_1"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="102"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="317" mass="35876" checksum="C3DAB724B2FCA5CD" modified="2015-04-29" version="1">MASLKGQRTKSPTYSHLLYLSETDRQIFTTPSSSSLRSSRSVHSYQTDTTAASASTRATSRMSIQAPRFADDHYPLITTIYPETVPESVPKDHAALWCARQMAQIHNTMIRALNSAWNHAVTIQPSTQEAEDFLFFNQQICSTLEHHHRAEDEHFFPTLEAMLGRPGGVEKIAKAHESFAEGLAIYQKYVFLTKASEYNGVTLRHIIEAFAPDLIQHLHDEISMLVALHVLDSKSVMKVWKSSEQLPATKYSDICVLGPWILGCQDKSFTIDGHKADFPEMPWIVELVAKGWFGRRHAGAWKFCPSDLNGRRRQLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6S7</accession>
    <name>A0A0D2B6S7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_07377</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234809.1">
        <property type="nucleotide sequence ID" value="XM_016381707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6S7"/>
    <dbReference type="STRING" id="91928.A0A0D2B6S7"/>
    <dbReference type="GeneID" id="27334460"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07377"/>
    <dbReference type="HOGENOM" id="CLU_017814_6_2_1"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="4" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="9">
        <location>
            <begin position="146"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="10">
        <location>
            <begin position="402"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW14593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="514" mass="56699" checksum="BD6F42B32CC10023" modified="2015-04-29" version="1">MKSLVPQYDSLSDVYPDLSAQDDTALSVRRRFLKLTNTFQQEFGHKPSFVARSPGRVNIIGEHIDYSMYSVLPAGIGSDVLIAVRVLPKAQDSLFSIKMANGDMQKYPRREITIGQSGLVEIDSDQHSWTNYILAGLRGSLPYLRGRLGSSFTPNDMEILVDGNIPPGGGQSSSAAFICASILSVMGANNYSISRDDLLELAVVSERAVGVFSGGMDQAASIFAERDCLIHCNFFPKFSTERISFPDSGCVFLIAQSFVTSEKAVTAPVHYNLRVLECTLAAVVLAKICDINLEKDESPLGYCLRNLQEQIMKKSGQASDSPETQLSSMIDIVNARLTMTSYTREEIAYLLQIPTEELDRRYISQVNVRAEFFKLRQRALHVLEEARRVDRFRNTLTNCGDLNRERLLYLGELMNQTQASCKTLYECSCPEIDQICSISRSSGAYGARLTGAGWGGGTVHIVPQDKVSAVINALRTEYYLKKVPGLSQEKLRTAISIFKPGQGSSLIGISALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAG5</accession>
    <name>A0A0D2BAG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_05603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235771.1">
        <property type="nucleotide sequence ID" value="XM_016379944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAG5"/>
    <dbReference type="STRING" id="91928.A0A0D2BAG5"/>
    <dbReference type="GeneID" id="27332686"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05603"/>
    <dbReference type="HOGENOM" id="CLU_124026_0_0_1"/>
    <dbReference type="OrthoDB" id="2663223at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW15555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="19184" checksum="09C97738DBC95145" modified="2015-04-29" version="1">MSELNPESQRTKPITITLSKSSDWDNWFLAIKVYAKQQGIWEYVDPEVLDPPVLKYPSIPDIYDANSGAVPSGTLDERQKLSIRFVERQWEHDCKKYEEKTKAIKALGSQIIGSLLIDLMQFLEGDHSPHVILLRLKRRFAPVERSRELDILTRWKNISKTPKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAY5</accession>
    <name>A0A0D2BAY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_06199</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236364.1">
        <property type="nucleotide sequence ID" value="XM_016380537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAY5"/>
    <dbReference type="STRING" id="91928.A0A0D2BAY5"/>
    <dbReference type="GeneID" id="27333282"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06199"/>
    <dbReference type="HOGENOM" id="CLU_015166_5_0_1"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="116"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="220"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW16148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="325" mass="35600" checksum="F498FCABFFE88CA6" modified="2015-04-29" version="1">MSAKSVKGEHGKKPASAAVNLIAGGGAGMMEALVCHPLDTIKVRMQLSRRGRVPGQKKRGFIATGRDIVKRETAFGLYKGLGAVLTGIVPKMAIRFTSYEWYKQLLADKDGIVTSRATFLAGLSAGVTEAVAVVTPMEVVKIRMQAQYHSLSDPLDVPKYRSAPHALLTVVREEGLGALYRGVSLTALRQGTNQAVNFTAYTEFKEILQRWQPEYQGQNLPSYQTTVIGLISGAMGPFSNAPIDTIKTRLQKTPAEPGQTAVSRIVAISRDMFKQEGFRAFYKGITPRVMRVAPGQAVTFTVYEFLKSHIEDSNWLKLGTGKYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBF4</accession>
    <name>A0A0D2BBF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236141.1">
        <property type="nucleotide sequence ID" value="XM_016380314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBF4"/>
    <dbReference type="STRING" id="91928.A0A0D2BBF4"/>
    <dbReference type="GeneID" id="27333058"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05975"/>
    <dbReference type="HOGENOM" id="CLU_026803_0_0_1"/>
    <dbReference type="OrthoDB" id="425936at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957">
        <property type="entry name" value="BLR7070 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957:SF1">
        <property type="entry name" value="PHYTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239016" description="Phytase-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="2">
        <location>
            <begin position="86"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="520" mass="55963" checksum="69D393150EEE1C29" modified="2015-04-29" version="1">MTLKAVLLSILAARFAFASPAPPAGTAVNTTTCNGQTYVYQQLAGYGFTPSDARDKFGDTAGGIGSSAAIDRNSWTVDKDGVYSGILWALPDRGWNTEGTLNFQPRVHKFHITFRPNYRATAQNPSPPNLNLDYLDTIRFTDPFGQPLTGLDADVHGPYLSFPGTPDLPSATYVGDGFGLNGTGGRRVSLDSEGLVLAGDGSFWISDEYGPYIYHFSAAGQMISAIRPPEALIPRRNGTDSFSADSPPRYNQDILTIPAENPTGRQNNQGLEGLTVSPDGKTLYALMQSALDQDGGLKKANRRNTRFLQYDISTATSPVLKAEYVVPLPRFSNNTKVAAQSEVHFISPTQFLVLARDSGAGHGQDSSSSVYRHVDVFDISNATNVANRFDCASCAVASNSSGTLDPAIVPATYCSWLDFNVNGQLNRFGLHNGGDQDAGLLNEKWESIALVPVNPSGPEDCNKPDGAKADGEYFLFSLSDNDFITQNGFMDGGKLPYADESGYDLDNQVLVFRVKIPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BC03</accession>
    <name>A0A0D2BC03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236366.1">
        <property type="nucleotide sequence ID" value="XM_016380539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BC03"/>
    <dbReference type="STRING" id="91928.A0A0D2BC03"/>
    <dbReference type="GeneID" id="27333284"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06201"/>
    <dbReference type="HOGENOM" id="CLU_042688_2_0_1"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34780" checksum="66F4BB11334B6B32" modified="2015-04-29" version="1">MASAAVQQPGGHSTSFEPLTTQLKGTSAAQTEKHHVRTSLNYYKDPGDGSPPPPSYVGKPETYERPYEPLDVTIHDIRGEEGGYTLDKNGFQIFRRESVEKDFVDDEQIKAQYYPETEQLLKDATGASRIFIFDHTIRRAPKDGRAAGASPAAINLRGPVNRVHIDQSYSAAKNRVPHHLPEDAERLLTTRYQIINVWRPIKKILKDPLAVADAHSVPDSDLIGVGLIYPDRRGETYTVRPNPEHKWYYRYGQAPEETLLIKCFDSKLDGRARRVPHTAFVNPETVNESSRESIEVRALVFYEDQPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEJ4</accession>
    <name>A0A0D2BEJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetoacetate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237206.1">
        <property type="nucleotide sequence ID" value="XM_016378529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEJ4"/>
    <dbReference type="STRING" id="91928.A0A0D2BEJ4"/>
    <dbReference type="GeneID" id="27331264"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04181"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF4">
        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="125"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="683" mass="76481" checksum="229EA7EF0E834AB3" modified="2015-04-29" version="1">MSSAPSKPPPEIVWRPSHNGTAPMDRYRQHVNRKYGLELSNTRELQRWSVTQPHEFWIDLYGYLNIVPPLPGSTRKAYDDTIPMSKNPPFFHGHLLNYAENALFGNPDSDVVALIGIRDDQDVYDDKAAETLTWGQFREKVRQTASALRRSGIKQGDRVGALVANSNWAVVLFHAAASIGAIFTCISPELGVEGCLSRLQQVTPQVVFVDSHTIYKGKAVSTDEKLRAILQRLNYRLQVFIVPILPHKYMASVPSMEDFLSRSSASDELTFTRVPFNHPLMICYSSGTTGAPKCIVHQHGWLMQVKKISTLHNSLGPGKMVMVYSSTSWVVFYAFCGHLTSGSTLVVYNGSPLYPDAKQLLRICEKFRVNFLGTSPRNLLEIEMLRTTVPRRDYDLSALEMVYTTGAPLSLEQYRWFYRSFPPRAQICNTSGGTDTASSLLIGDPCGPIYAGELQIYALGMDVDILDPASGVSIAETGEAGEMVIRRPFPSMPCCFWGDTDNKIYHDAYFSRFPDLDVWAQHDWLSQNPATGGYVMHGRSDGVLNPSGVRFGSGEIYAIVEAQPFTEYISNTLCVGRRRAQDTDEHVFLFVMMKPGFSLTNEMRARIKTAIRNALSPRHVPRFVLEVPDIPITINGKKVEIAVKKVISGARDVKPSSTVQNPETISWFRRFKDLESEPTDSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF34</accession>
    <name>A0A0D2BF34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prenyltransferase alpha-alpha toroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_04773</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237794.1">
        <property type="nucleotide sequence ID" value="XM_016379117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BF34"/>
    <dbReference type="STRING" id="91928.A0A0D2BF34"/>
    <dbReference type="GeneID" id="27331856"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04773"/>
    <dbReference type="HOGENOM" id="CLU_028946_2_0_1"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="8">
        <location>
            <begin position="9"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="406" mass="45053" checksum="A5F8BA0C2426F8DC" modified="2015-04-29" version="1">MPVDPNLRLDIDRHVKYWKRCAQLLPEQYTAGESNRMSFGFFIVAALDLLDAIETATTPEERHSWIEWIYACQVPFTGGFRGFTGTNLGSMRTLHNWHWDSANLPNTYFALATLVILGDDLSRVKRKECVAWVRSLQRENGSFGEFLGEDDAVEGGDDPRLCMCALGTLSILQGTEQGVGDSPIDTVKLKEYISNCQSHDGGIAQQPLLEAHSGLNYCGIATISFLGLLQSPRVSAYDVSSQAGLDIEACIKWMIDRQTTWIEEDEEEDEDDVAAPRFTDQDKSSSATAAEAIQSLEQKTIAGFCGRCGKMADTCYCFWNAGALAILQRQELVDIEALRCYLLEKVAHLIGGFAKAPGELPDLLHSYTGLAALAIYREPGLKELDPTFCFSRQSVGKLKNVAWRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFM1</accession>
    <name>A0A0D2BFM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230375.1">
        <property type="nucleotide sequence ID" value="XM_016385431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFM1"/>
    <dbReference type="GeneID" id="27338203"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11120"/>
    <dbReference type="HOGENOM" id="CLU_156018_0_0_1"/>
    <dbReference type="OrthoDB" id="5394455at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="104" mass="11218" checksum="40AFE1DF9B4175E8" modified="2015-04-29" version="1">MQVAAFLSDLKSLSICSHEAAIAVVVPENVGQRAQTPARPNTGFISSTTEPLPLGLANDQELTRANELVSLHHNVKVKYLETGPDPELEQAAAMVDRVIQDLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFR5</accession>
    <name>A0A0D2BFR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Nucleus and/or cytoplasm.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230425.1">
        <property type="nucleotide sequence ID" value="XM_016385481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFR5"/>
    <dbReference type="STRING" id="91928.A0A0D2BFR5"/>
    <dbReference type="GeneID" id="27338253"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11170"/>
    <dbReference type="HOGENOM" id="CLU_007630_1_1_1"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="6">
        <location>
            <begin position="224"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="871"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="968"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="968"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="993"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1026" mass="114006" checksum="17784E79AC1BB54B" modified="2015-04-29" version="1">MADSDQEHFSPSATAEEAGLGGATDAAEAESAVQPSTSELPVDNLSDPILSPTQSTLHPLSMKPISQVSSQAATPNMAESMSPVPPQSQSKPRIVGGFEVDDDEEDEEEAGQDDKDDADFYDPAVGLDFDAPTPAAPSNPLDRTSQSPEQENGITPVPVQATGSLTDISSSTLPPSGDAPRAATATPTQTVPATPAPVQPSPPRSYVNGTVSAALPKSRLAHDVIGILEDRIKDDPRGDTAAYLELIDELKSRNKQDDVRRIYEQYLTVFPLAAEQWCAYVKWEEEHDRLRAMETLFNRSLLEVLDVQLWTLYINYIRRRNSMQSGDVTRSYNIINESFSFALKTIGMDMSSGPLWQDYITFLKSGPGIIGGTGWQDAAKVDTLREAYQKAIAVPTAATTVLWKEYDAFETGLSKINGRKYLQEKSPVYMTARTAYTQLQNLTKDLKRTSRPRLPPAAGYDGHTEYLHQVHLWRQWIEWEKEDNLVIKDEDLALYRNRILFTYKQALMALQFWPEMWYDAVEFCFANGLENDGIKLLNQGITANVESPLLAFKLADRIESSTQNDEAADPGARERMKKIREPYDRVLDALYDLIKKVAAREALEIQRTEAAATTNGDTDGAEEDEINAANVTARKAVVDGQIELIRKTAQAQTDMLSRTISHVWIALMRATRRVQGKGLPGEKGPSGFRTVFGEARKRGKLTSEFYVESARIEWQCYRDPAGTKILDRGMKLFPEDEYLPLQYVKHLFEINDVTNARAVFETTVKRLLAHDDTVYTAKAKPLFAYLHDYESKYGELAQVQSLEERMRKLFPEDPDLKLFSSRYSTATFDTISVHPVISPTQTREPQTSVVPSIEMPDVVNSPIQKVIDSITTNSPKRPYPEDFEDVGPRKMARGESPLKGAAGRRINQQQQRQTNAPAGMPAFPVPPPLPPQITYLLSVLPKASTYVDARLDATKMVELIRDIHLPPPAAVTGQQPPPQPVSAAGWQSYPQHQPSPMPPQGFMPPPGVSQAPYGSGEWIKPLLMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGF2</accession>
    <name>A0A0D2BGF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cdc23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238264.1">
        <property type="nucleotide sequence ID" value="XM_016376694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGF2"/>
    <dbReference type="STRING" id="91928.A0A0D2BGF2"/>
    <dbReference type="GeneID" id="27329418"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02335"/>
    <dbReference type="HOGENOM" id="CLU_018320_2_0_1"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="22"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="400"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="434"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="502"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="608"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="662"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="675"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="775" mass="85855" checksum="448FFEDBDF876EA9" modified="2015-04-29" version="1">MSQHRHESFGSIGEVDADIVSELRDRLTEATIKCSERCLYQSAKWAAELLNSLAEDHDHHDDDSQMRDTNNVQSSYRIFSTSYDDPDEAMLEAKEAPKYLLAKAFFDTKEFDRCAAVFLPPAIPAGGLAIFEKTKGRTPISTPSRYKTKGKQADTTTPNPYPRLSQKSLFLALYARYLSGEKHKEEETEQVLGPADGGQTVNRELPSLARGLEAYFRSRDAVDPTLKRSQGWLEYLYGVVLAKSRQETLAHQWLLRSVRLNPYHWGAWEELVSLLASGDELSTEQTTPSLLPSNIMSIMYQAVASVELFSTTDQSRTVSYLQTLLSYFPTSTFLLTQLATLHYHAKEYDTAASIFQDLLVTHPHRLDGLDHYSNILYVMADRARLAFLAHLATSVDKFRPETCCVVGNYYSLCSQHEKAVLYFRRALTLDRNFLAAWTLMGHEYVELKNTHAAIESYRRAVDVNRKDYRAWYGLGQAYEVLDMGFYALFYYQRAAGLRPYDPKMWQAVGSCYAKMDRLDQAIQAFKRALVAGTYVDDAGGSTQSSFTAAAKGSKGHAQAQAQAQPRKLLDPDTLYQIALLCERKAGPSGDAEAAKYMELCVAQETGGSVKGVSQADKVSGKRARKNEERRARAMASASASSSALFAGGQRHYGTGATTEATAAAADDGTGAGRDDDTEILSSSDDEPDEENPDDAAAADDDDDAEANQDGFGTGTTATTSKARLWLARRCVRIGDLDRAERLAEELCMDGYEVEEAKGLVREVRGRRGGMLGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHG4</accession>
    <name>A0A0D2BHG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238624.1">
        <property type="nucleotide sequence ID" value="XM_016377054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHG4"/>
    <dbReference type="STRING" id="91928.A0A0D2BHG4"/>
    <dbReference type="GeneID" id="27329779"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02696"/>
    <dbReference type="HOGENOM" id="CLU_027514_1_0_1"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="536" mass="61140" checksum="4D239686AA2748DB" modified="2015-04-29" version="1">MFQQHPLDANGKLLRRFYEPLTLLRVMDPTRGAQRPDLTSDRGLDEQSKLWRNFLDQLAFVCDSEKRGDTVAAIAAQRSFEHPIFSLASNSKSRSEARGHLCWVLAALGQIHTNEKPRLQVEDEIRTRCIDFSHQRIQTYSRWLIQAIQTATNMMDEVSNAEDAFILKEFQQLETLISTPHRQCSHAHTLRRCRLMEILSIRHVAHAHRGVWSDLRHYLGRLGSWSKAVQILVLGAVTFPQRIENAQVEIIGTNGPADLPNKLHSTDLVGVVRRMVPIDQIVVFEQLNQALSEANAVAEVEDRFRQEYAQIKPRPHAELLILEHFYRNGLDFVTDDRYIGCSKPSCYCCHIYMQCHPGRFAPRPCHGNLWINWAPPYPLPIPDPHAVTTKGTARPQKHHTFKMLQDMLIYIRRDLQEQILSRRPERARLPDSTTGMSSVVLDLDALLGSARNASQPHNGHNSNNLDDHGVSVLVSRDSERRSAGNRTSQEVPSTNEPEQSTEQDQKGFPEGQYEHFTDSDASEIIVFRGRKKVNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHU2</accession>
    <name>A0A0D2BHU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_02493</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238421.1">
        <property type="nucleotide sequence ID" value="XM_016376851.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BHU2"/>
    <dbReference type="GeneID" id="27329576"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02493"/>
    <dbReference type="HOGENOM" id="CLU_000991_0_0_1"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15518">
        <property type="entry name" value="PHD_Ecm5p_Lid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15543">
        <property type="entry name" value="PHD_RSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000010">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000014">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="13">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="12">
        <location>
            <begin position="140"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="459"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="14">
        <location>
            <begin position="600"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="243"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="383"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="998"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1476"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1188"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1500"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1539"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1725"/>
            <end position="1735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW18205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1757" mass="197056" checksum="E9461E58BC7DCD9F" modified="2015-04-29" version="1">MVAPPSTGGVAPATATAKPSSATRMNGVGPNIATPAFPYSARHAQPLDMRTVERKGDPASRDPPARSRQYGLLEAPTYRPTEAEFRDPMEYIRSIAPNASKFGICKIIPPDSWNPDFAVDTERFHFRTRRQEINLVEGGNRTNLNYLDQLAKYHKQYGQHLNRFPSVDKRPLDLFKLKKAVEVRGGFERVCKDKKWAEIGRDLGYSGKIMSSLSTSLKNSYQRWLHPYEEYLKWAKPGVQQQLENEQGGSYSPAVLAHQSPVSHPPPSQSAPPAMNMREPSQPRHSSANGPMHPVPTPIQQQQPSIVPAAPAPQPRPVSSSGFTAVNSGFPAVNAPSGFTAVNTLPPPIVKSEVNGTPPPPPNHTSSFMSVNGPTISAVPLAAHLHNGGSNPLKRTMSHDSLTGESGSEAMHGDEDGPNGRRSKRPKKDGMPTIPGNHVPAMRPSTPQVRSKSTPRRHGERCEKCGKSDHKESIILCDSCDLGYHMQCAEPPLTQAPSEWHCPKCLVGTNDYGFEEGSIYSLKQFQEKANNFKENYFAARMPFDPVTNTQRRPTEDDVEREFWRLVEDLTEQVEVEYGADIHSTTHGSGFPTIEKQPLNPYSKDPWNLNVMPFLEDSLFRHIKGDISGMTVPWLYVGMCFSTFCWHNEDHYAYSANYQHFGATKTWYGIPGSHAGRFEDAMRKAVPELFETQPDLLFQLVTILPPNQLRKAGVDVYACDQRAGQFVITFPQAYHAGFNHGFNFNEAVNFAPADWEPFGESGVRRLQEFRRQPCFSHDELLFTAALSDTTIKTAKWLGPALERTRDRELHERAYFINIHKTRLPHDECAFDSLATEPPKACGLTVKIDNSDLEEDEYQCCYCKAFSYLSQFRCHRSGKISCLLHPLKADCCGDSDEERLKGTNHSLVLRYTNQELSNIVQKVVDKAHVPELWEAKLDALLAEEARPSLKALHTLLSEGEKIPAPLNGLDDLAEFVRRCDQWVDEANLYLTRKQQNRRKNEKAWRRSSLRTGKGDEKDNEPQLTLDRMKELIDDGEQLGFSTPQLESLQEKVTLIDEWRANAKRILSGMNQAGLEELEGLLEEGRGFSAAMPELTSLEKIYARTQWLEESRQLQKDITSKTLDECRSLLERITELDILPQAPEAAFVNDMVKQGEFWEHKAKELMAAEDVHYPQLESLHSQVHLQMFPVNKEVLDKMDQILAKNREAKRQIITLVERSHDPDLRKRPLYAHVRDVVKGFEELNGKPHGAADLEKELRRHEDWMRRGKKLFGKANAPLHILEQHMKFVEEKNNFCFDLNDTFRPPVEPASREATPADDRGRGQLGEDEKPVFCICRQPEAGLMIECEICHDWYHAKCLKLARGKVKECEMFTCPVCDWRVKIPRDAARPKLEDLQGWQDEIADLPFQPEEEELLKRIIDKAQAFRDFLSQYTNGNAICRTIEEMPEMLFYLRKIEGAEVLLAYETNLFRQELHKWQPIAPEPPPILAQSLSTRKPRPTKQQKLMKELGVEKPEDLPPHLRTKTYVRRKTQESFMTGPLLPKPSTQSPSAPGSAASPGHSQSAGNAETPGTGQRQGSAGASGAGGTIEPGFIAGPASYNNFGGDRPESFPPNSPSPMFSPTGERPPQGMKDPMMPTFAGGASSRDARNHDPSFPMFQPNTGLDADDDLRNGLANASPRGTQSGRDGSPGEYDTMFMDITNQEGDGSNDAVPSLEHETSHASEALDMIRTASNDSGNNNAELEDGDNVSKHFDDFLTSGEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIN9</accession>
    <name>A0A0D2BIN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238656.1">
        <property type="nucleotide sequence ID" value="XM_016377086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIN9"/>
    <dbReference type="STRING" id="91928.A0A0D2BIN9"/>
    <dbReference type="GeneID" id="27329811"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02728"/>
    <dbReference type="HOGENOM" id="CLU_018354_9_1_1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW18440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="471" mass="52812" checksum="22CC72FB09D18406" modified="2015-04-29" version="1">MGSTQESLPIIWRHETSEAEYEQATVGRVFNMRRPTRRPLAVVHAANESHIVTAVKLAIQQKCRVAVRSGGHSWAAWSVREDSILIDLGNYHHIELDEANHTVCVSPSTTGKTLNGLLKEKGLMFAGGHCPDVGLGGFLLQGGMGWNCKNWGWACEQLFAIDAVNSQGELVHCNTTENSDLFWCARGAGPGFPAVVTKFYLHVRPAPTHMLSTVLFYPLSKYHEVMEWVIKTSKGYDKDTEIVSVAATPPAELGITQPCITPLFVTFKNSEEEAKAALKIANETRPAGALHELINHPTNLAEQYKNQAEANPENHRYCAENAYISNDADVPAVLERAFTTLPTSKAFSLWYAMYPCSRRQLPDMALSMATDHYFALYTVWEDASDDARCRKWVKDIMTDVERHSDGSYLGDSDFQIRRTKFWKSENGTRLMELRRKLDPTGLICGYLDEDDRSGTDGLPNQQEWRELHSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKV9</accession>
    <name>A0A0D2BKV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Biotin-[acetyl-CoA-carboxylase] ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239784.1">
        <property type="nucleotide sequence ID" value="XM_016374508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKV9"/>
    <dbReference type="STRING" id="91928.A0A0D2BKV9"/>
    <dbReference type="GeneID" id="27327224"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00141"/>
    <dbReference type="HOGENOM" id="CLU_006150_1_1_1"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03144">
        <property type="entry name" value="GATase1_ScBLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="427"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="742" mass="82154" checksum="3EBE7AD3EDE45B0F" modified="2015-04-29" version="1">MATKRMNVLVYSGALTQEAWRANENLMLSGNGSTVESVRHCLYTLRRLLSPNYAVIPVTGDMIIKEPWTATCAALVFPGGADQGYCNTLNGEGNRRIRQFVERGGNYIGFCAGGYYGSSRCEFEVGDKLMEVIGDRELQFFPGIARGCAFPGFVYHSEKGARAADLKVDKTVMSAGTVPKVFKSYYNGGCVFVDAPKFKSQGVEVLASYTEHVAVDSGEGSAAVVYCKVGQGAALLTGPHPEFVFLGKPADDWSLTKPRFASANLESKPDVPGFSDVIKTLAADEKHRMDFVKACLTKLGLTVSDDQNVPSLSYMHLSSYTPSDTTQLLASLQHLIEKDEEQQDFLRDDNDTFHIIKPSAWETKDLAEALPLQVDNKRSANELDGSSDRIVDYNTVTKHIIVHDNSQPESKSTPYFNHRAFYANLEHYQSQFPSTSTFGAHLLYGEVVTSTNTLLEKNTKLLRNLPQGFTATATVQVAGRGRGSNVWVSPPGSLMFSTVIRHPMTKMQAAPVVFVQYLAAMAIVQGIKSYDGVRYKDMPIKLKWPNDIFALDLAKAEENGGDRNENYTKIGGILVNSHYNSKEYIAVCGIGLNTANAAPTISLNQLIQFLPRKVEPFTLEKLLARILTVFDDLYARFLVTGFDETMEKIYYEHWLHMDQIVTLEAEGGQRARIKGITRDYGLLIAEELGWEDRETGRRWTLQSDANSFDFFKGLVKVCGPCCGEPNLQLSPRTKALIVFAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL92</accession>
    <name>A0A0D2BL92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1746 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239944.1">
        <property type="nucleotide sequence ID" value="XM_016374668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL92"/>
    <dbReference type="GeneID" id="27327385"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00302"/>
    <dbReference type="HOGENOM" id="CLU_1081960_0_0_1"/>
    <dbReference type="OrthoDB" id="5428737at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038967">
        <property type="entry name" value="Dsc4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013715">
        <property type="entry name" value="DUF1746"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08508">
        <property type="entry name" value="DUF1746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1746" evidence="2">
        <location>
            <begin position="30"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="257" mass="28009" checksum="CE58D1D255A1EFF7" modified="2015-04-29" version="1">MNNDSALNSERSLRVGDSKNDYLRSLLRTLDAVIFLQIGITYLSDNLTLLLILRAISQVVHVQYRPTGLQLAPAVFVSVVCIVTHLLWTQSGTKHTHGGLIIDFVGELPPSKWRLLLLDVVVLALQLVMLVVGHQKQLALGHAQPQPDTPPPQDIEAEEEGRLVSNVQERQTGGEEEGIELQSLLPNGAEREHSSSNPLTKTATQEADLIVLDMKTALTALFRKPLQPSSHAVEDPAMRAGLANVLSRVAAAHARAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLH2</accession>
    <name>A0A0D2BLH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239636.1">
        <property type="nucleotide sequence ID" value="XM_016378066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLH2"/>
    <dbReference type="STRING" id="91928.A0A0D2BLH2"/>
    <dbReference type="GeneID" id="27330798"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03715"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="247" mass="26271" checksum="5062A7D96E2A9EB1" modified="2015-04-29" version="1">MEFKSLRGKIIGVTGGASGIGLAIVRKLLAVEAKVAVADLSPQPEELANNPNVIYTKVNVTSRQEVHSWVEKIVEKFGRLDGMCANAGICPVENGVASDDVYRRIIEVCVTGVWNTGTEAYRQFQRQKGGGVLVNTASAAGLKGYRNMAVYSTAKHAVVGFTRCWSLDWAPEGIRVNAIAPGFTESPMTDAVIKDFPQVAEHMIAAIPLGRMGKAEELADSALFLLGDSASNITGSILVCDGGMLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLW7</accession>
    <name>A0A0D2BLW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232400.1">
        <property type="nucleotide sequence ID" value="XM_016383777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLW7"/>
    <dbReference type="GeneID" id="27336543"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09460"/>
    <dbReference type="HOGENOM" id="CLU_042177_1_0_1"/>
    <dbReference type="OrthoDB" id="5391950at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="233" mass="25610" checksum="FE5445869139EA7D" modified="2015-04-29" version="1">MTSASASPKRKRGQETHLETRVILSQQLFAHDVDEEDTGSPRTKVARKFDGLEIDNDLFTLQHNHTSSSPRPCQTAQLSATSADATSGRSIDAKSMMPTQPPSTSSPAVAGNAQSISAASLATKSRSGSPPLAGELSDQFWHDSEITGHDPDPDDPDDDLYGINGVGFRPTAAIAWSRSRRRKQQLEEYKNREAREARQQRSERRKRGISDSEDVPSLDNSPRKSVRVHFEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMM0</accession>
    <name>A0A0D2BMM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240046.1">
        <property type="nucleotide sequence ID" value="XM_016374770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMM0"/>
    <dbReference type="STRING" id="91928.A0A0D2BMM0"/>
    <dbReference type="GeneID" id="27327488"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00405"/>
    <dbReference type="HOGENOM" id="CLU_029210_2_0_1"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="248"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="467" mass="54157" checksum="3E3B2D5F17DBFE8D" modified="2015-04-29" version="1">MSYQNGNTIDEDDQLEEELVQDYREQIQYNDGEDIERTDSLSGPADIRAQLEAAAAPLEYQASLETKFASYDNYCSLFHYILNSDGPVDIEQPSYFWAWDVIDEFIYQFESFCRYRNRVARTAPNEEEAQVLRENPNTWGCYSVLNVLYSLIQRSQINEQLAAQKRNEDPNTVAGEYGSRPLYRMLGYFSIIGLLRVHCLLGDFSLALKTLDDIEMNKKAMFARVMAAHLNTYYYVGFSYMMLRRYADAVRMFSHILVYVSRTKNFQKGNQQFDAIAKKTEQMYALIAICVSFAPTRLDDTIHTALREKYGEKFARLQRGGTESLPVYKELFQSACPKFITPTPPDFDNPSLNIDPVEHHTDIFMDEVMNTLFNPTVKSYLKLYTTMDLKKLSSFLEVEPEKLRSWLLVNKQRSRQTRWTEGGLLDGETVNGSELDYAIEGDLIHISEAKQGRRLVDWYLRNLARSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMR1</accession>
    <name>A0A0D2BMR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_09706</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232645.1">
        <property type="nucleotide sequence ID" value="XM_016384022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMR1"/>
    <dbReference type="STRING" id="91928.A0A0D2BMR1"/>
    <dbReference type="GeneID" id="27336789"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09706"/>
    <dbReference type="HOGENOM" id="CLU_008024_1_2_1"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="158"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="324"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW12429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="642" mass="69827" checksum="346BD653D1FBC9FE" modified="2015-04-29" version="1">MPGSQSTASPLKTEVPLGPGGPGSPAPPITPATPDSSTTIPPQSVPKLPPSPAQVQTAPPTSSSTVSPPEPTPPPPPPKPAAPAPRRFRRLRALLYLLLFGGLAYGGAVVYALRNDNFHDFFTEYIPYGEEAVLYFEERSFQKRFPHAKHNIHRINRSEREAVDGKTTTIPQRSGLSWRPVKDEPKGSDLTQKGKHNSAVDANKPSTPSQTGPVSVTSSEKVNAVETAKATASASGEKSPGSTVPSPAPPSPKSDPRPPAIPPVTQISPLTVGNADEPVVQELVKIVNDMITVVNSDSPDAANKYSAPMTKAKESLEAVASKIHEVREAERKAAEERVAQAHKEFEEGAQQLLKRIETAQAEDEARFREEFEAERRRIAQLYEERLKHEVQRSTELTEQRLRNELVEQAIEMKRDFVSQIKSLVESEREGRLSKLSDLSTNVEDLTQLTSNWNGVIDANLATQKLQVAVDAVRSALAQSAASEARPKAFVREMAALKLAAEGDPVVDAAIASINPAAYQKGIPSQPQLIDRFRRVANEVRKASLLPEDAGVASHAASFVLSKVMFKKHGQPTGSDVESILTRTETLLEEGDLDSAAREMNSLQGWAKVLSKDWLGDVRKVLEVKQALDVIETEARLQCLRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN61</accession>
    <name>A0A0D2BN61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240594.1">
        <property type="nucleotide sequence ID" value="XM_016375318.1"/>
    </dbReference>
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    <dbReference type="STRING" id="91928.A0A0D2BN61"/>
    <dbReference type="GeneID" id="27328036"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00953"/>
    <dbReference type="HOGENOM" id="CLU_019419_1_1_1"/>
    <dbReference type="OrthoDB" id="2351940at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
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    </dbReference>
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        <location>
            <begin position="43"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
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            <begin position="364"/>
            <end position="510"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
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        <location>
            <begin position="97"/>
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        </location>
    </feature>
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        <location>
            <begin position="111"/>
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            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
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            <begin position="368"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KIW20378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="558" mass="62821" checksum="B84B6380D8ABD1A6" modified="2015-04-29" version="1">MSDHDDNPWSDISTRLQNLRNLLSSERHLFTDHQRAFEAIDEEMGHQIAANQPSTRERRRRDIESHMQEEESHSMSEDLSQTGNPSSLVRSRRRAFRPSERLQRYQRERLGQSSRTLPSETSISPSTQPNHDRGDRLRAKRRKLDDGTYEDEPRTFRYGHKGQVVPGLLRMEIASCDGGEYSDPRVSINSYPQHVLVDDASVYCTKTSRCNLLLKHVGGMPFTLTKIVIKAPRAGFDAPIQKGLIFVSMNEDNLLEKASRYDLLYGPENHRYISLRDVTRPSREYMNSARSPLRSVDRSRYLEDPIGQYAAPATDGSRNGGGLTDSSDGEEEAEEAAGPASPRPWQDDEYSLRSYVDRYRPLRAMNIPDDESESSESESWDDPERAGWRRQHADEDTPNREARVPALLQGDDLHENDESFSERDGGSVNDGTASRRRRLGRRPVDTSAADAFQSEPVSPANEPLSPSGNLPGDSTAKSSRFEPEASSSVGSSNTVTPQAQFNISRSKSRASVKFDPPLSGRYILVKLWAQTTNNNIDVQAILPCGYGGPRFFPSNDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BND8</accession>
    <name>A0A0D2BND8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016384237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BND8"/>
    <dbReference type="GeneID" id="27337005"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09922"/>
    <dbReference type="HOGENOM" id="CLU_1652167_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="160" mass="18197" checksum="CF101A7A0BDC8F2F" modified="2015-04-29" version="1">MNRVRWMYWARGWWSPEKEAVTALTHGSGEDEACHLAPRVVLWRIVTRRRPGTAKRPSSNLRESTKFLPSDTGSNTNLHTVPWSTARLYGIAANFIRGTMVPENERRFDTDSFTVLGQARVKSHTATALPKQFVACEIQDPNLVIPNYRSQISIPIYGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP26</accession>
    <name>A0A0D2BP26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <ecNumber evidence="5">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_00855</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="5"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240496.1">
        <property type="nucleotide sequence ID" value="XM_016375220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP26"/>
    <dbReference type="STRING" id="91928.A0A0D2BP26"/>
    <dbReference type="GeneID" id="27327938"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00855"/>
    <dbReference type="HOGENOM" id="CLU_013640_4_0_1"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000242">
        <property type="entry name" value="Dihydroorotate reductase PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="15">
        <location>
            <begin position="126"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="15">
        <location>
            <begin position="554"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="436"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW20280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="616" mass="66973" checksum="A609D08F3790143B" modified="2015-04-29" version="1">MKLPTSRVFFRPPPGRVIARPTFAKPQFTAHSIRRHNSTAQTGSTGGSRLLNFVYGSTLVLGLGIIFVYVTDTRASVHRYVVIPALRWIYPDPEEAHHAANQVLRSLWDFGLHPRERGDPDKVGDLEVEVFGRIIRNPIATSAGIDKHADIPDPLFASGPAIVEIGGTTPLPQPGNDKPRVFRLTSQQAIINRYGLNSEGADHVAMRLRDRVRKFAYRLGLGHDAAAEHAVLDGIAGVPPGSLTPGKLLAINIAKNKTTPEDDVDAVTKDYVYCVNTLGPYADILVVNVSSPNTPGLRSLQQGDKLQKILTGVVDAARLVDRKTRPAVMVKVSPDEDSDAQIAGICDAVWAAGVDGVIVGNTTNLRPAPIPHLGNLSPLEEQHLLETGGFSGPHLFDKTLSLVKRYRKLLEQKPVELEPVPQPPSALQAEAAKIKNELASESGPKEDSTPDTVTTSVDTGVIPPTPVAEEMSSEKQPLFKLPQERFYDKPQEDQDSLEGVNSAPVDSPGEQQSQTERLRAIQAAIERLPPRDQRDALENLEEPIHLASNDEPKVIFATGGITNGKQALDVLNAGASVAMVYTALVYGGVGTVSRIKDEMRTEMRRQAEERRSKSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP62</accession>
    <name>A0A0D2BP62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233105.1">
        <property type="nucleotide sequence ID" value="XM_016382402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP62"/>
    <dbReference type="STRING" id="91928.A0A0D2BP62"/>
    <dbReference type="GeneID" id="27335159"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08076"/>
    <dbReference type="HOGENOM" id="CLU_045150_0_0_1"/>
    <dbReference type="OrthoDB" id="5413281at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="160"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="282" mass="29848" checksum="F4AB76AE84127919" modified="2015-04-29" version="1">MTSIFDSLGSLCQSSPSHPQSLHGSSTLNPLHALSEQDNQRARSLFLTLHVLFPHELLPALDLLDRGLVTRLITLEAPEVCATGIIDSHFVSEPTESSSGPSGSASAPLSAGHQTLEGQEPNHFRDEVFYIQSSSASSSSSAAATSHHRKQTSSGAAPFYEVRLDSWNCTCPAFSVSAFHSLMMKGHYETKTEAEPVPAGPPHRWTNNQGKGESKSSTWRFGGVAVDTASTSSPRPPSCKHILAAVLAKAAPGLFAHGVTSRTVSRDESVGWGAGWGEFGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPM9</accession>
    <name>A0A0D2BPM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid metabolism enzyme regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241129.1">
        <property type="nucleotide sequence ID" value="XM_016375853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPM9"/>
    <dbReference type="STRING" id="91928.A0A0D2BPM9"/>
    <dbReference type="GeneID" id="27328575"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01492"/>
    <dbReference type="HOGENOM" id="CLU_010147_0_0_1"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="86799" checksum="120E61CE3D19DD9B" modified="2015-04-29" version="1">MSDRPAENAPPLGNGIVESSKTSREGSPVRPSRSISAIPQLSPSRKSSQEFSPTRGTATSTVPSAAAVQRALSAQRPILQPGREGVAEGSRLSERTQRQSTPSWSASPRVKSPPPNPNKSTTRASIKRSESEPTPSNTSLKRLAAVAHPDQGVVMQVPENTETLFQPSVPLRAPGRGPSAGGSALETVAESSVPSTPSIGPVQDIIDNKIDVPALDKQVEPHPDSTATKDGEGSGGDAPSKTGTAKADNGQGSRAASNSRPASDLAKRSFTSLTGPKPKTTTEPPRTMTVETETVTSIPQLLGPDRGVSGRDGNGSVRTKPSTETIRPKKEKKRSSRKPASLHAGTVTSKADLFEARVASAVDEADTSDSDETFVYESNPPDSRPSRHHSRTPSATSLASQEQYGGRSKHGLRNGSHAIAGKKSMKFSNSTYNNHLDGEAGLEGRGSQRNTSTTPRHHHISRHGRPHHTSILDTDSPFTQASKASSPRASVTNLSRNSRPNSPRLANGRFVGPPRKSDPYDISDDAADDERAPLIGSVRINRTRYSRRPHSASFRHLDYSDTYDRGYCSRHGGCIFLVFVVALICVGITTFVTALNRPLSDVSIKHIQNVLASEQELMLDLNVEATNPNLFAITVSELDINLFAESAYVNSGPEWRKEQGHLRFVNRRSPSSSELMWPPWHTDDGVDEGTDPIDDPEPGTQKMLLGRILEFDSPLVFDSSPIRHSRTSSVGEIRLAKPGNKTEEGGSARWEKVLHHQFDLIVRGVIKYQLPLSSKTRSAKVGSRIKVLPNDDSGDEPDDSPQPTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPV2</accession>
    <name>A0A0D2BPV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233365.1">
        <property type="nucleotide sequence ID" value="XM_016382662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPV2"/>
    <dbReference type="STRING" id="91928.A0A0D2BPV2"/>
    <dbReference type="GeneID" id="27335419"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08336"/>
    <dbReference type="HOGENOM" id="CLU_022728_1_1_1"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="594" mass="63878" checksum="03598D65BCF674FE" modified="2015-04-29" version="1">MISQKASSSPSSSTWVDQALPIPGLLLTSTVAFTLLGLKVNEWRGSERFAEFITNDRTTVAIAIQIVSHVLGLIQVQVLCTVIKSSFTASTASRTFSLNAFQFVHAASIPRVSFSLPWSLSMPLITLVLLSFFPSALWSGAITPILSEKVTSQPSMIPSFQTTNLSALWEGNSSTSTSGSGSLGQWLTADGLFSYDPSALRNLILNSASDASTTNSSGHLHQKLDKTGFLYLNRSYGVGAATGLIDVAGTSSPQWVSYFEPGFYSNVSCIYNASSAYRIDKLDTPSGWTLNVYQAAGSYPTGDSTGGWVYVGYSAMDIFSWGVIYKNKTRRSYVSLTTAANESQDAWSFSGFNNIQCQIDFEARNYSVQVNHTNSVISVTPKEGLQWPSYADAVIDEVTTWLWVFSYVDSSFGGSYLGRTLRLNVNQLQNATGDFSSDTTLRGVSDYLSSCVDNILVALSSARLVAANATLPVEASVGVPAVTFGETEYIGSILALNIFVCLLYAAEALRTRFWRNMPQLDLMDLTSVVLAAWKGGIGLVSGGTEDDVFGVDTAAKDIRVTLDGSKGGIPCMVPLSASQIIVNGKESVLAKSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPV6</accession>
    <name>A0A0D2BPV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233370.1">
        <property type="nucleotide sequence ID" value="XM_016382667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPV6"/>
    <dbReference type="STRING" id="91928.A0A0D2BPV6"/>
    <dbReference type="GeneID" id="27335424"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08341"/>
    <dbReference type="HOGENOM" id="CLU_025462_3_0_1"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="58982" checksum="9B83CE8823C7A17E" modified="2015-04-29" version="1">MSSVVGEHALLWIGLALCASVVTFLSLNQRQRDVIIQRLQLRGRRASSASTPPRSLSPDKKDPSNAPPKSTEYVNTFPPSIREGLEEATAKLPPAQREAMGDLFFDEKTWHKSILGFDEDFRTADPSKYVFTGVKIQEIRALGDFPDYSTLSGVPLPEPYLEHDIDKALPRPYRPFRWAYHQTMSLTKLEPNWWLELENTYRTRIAQRKKLYAEHGEAVLQWLPGSELACKELMEMCLQFLCARYPQYFTLHEDKRTFENKILKTTQDVKAKHPLLVLLDNVPEDFAITLRNPETGYYHFRAGMICSALGWNVGTKIGMQLAQIHAPIPDYKEKMQFSMDRFFTKMPANKPIQRGSWGLEVDQPLYMPPGDPHEKYRDFQMPDLDLERIHLRVDWQTLRRLPLSGGIVFNFKALFTPLTEFRDEAYVPSLVLKVLREGKENLMKYKNTWHVEHKVLPALEEYEAEQMANGLVEKDWPVHTLDDSPYFPGWREKWGARQGWIPKDMSPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BU01</accession>
    <name>A0A0D2BU01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234970.1">
        <property type="nucleotide sequence ID" value="XM_016381868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BU01"/>
    <dbReference type="GeneID" id="27334621"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07538"/>
    <dbReference type="HOGENOM" id="CLU_021421_0_0_1"/>
    <dbReference type="OrthoDB" id="4160615at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="477" mass="52861" checksum="112A51BF4EAC3B4C" modified="2015-04-29" version="1">MEHSLSGRIEAGGSSDGTVVATPGAAGVDDNVDQEVRDTLAETPYEEATADETTDFPPLPDLGNIEARHLRRTSNHEARTLERQGLLYTDLYRQLQLRPERYLEFYTGVLWPLRYNHLEEVQRGTPAGHRALTNRLLRRYGDTIWPATSTTGSGWLIDDAELNEGEVRLKYVKPPSRAGASTVPENGPFFTIFDAFWARMRNAIFTIRTQSGGRPRTSSNRNDDPAAAAAALDQTIMFLTREETRASLDHIQARLLEVLQESDPQIFAEEWVEMFGRLQVIESDLPMAPAVVAMVNGTTDEGPPPAMSNEPFISQGNPVRDPQSTVPPTIIPSVMSVWITTVYVPPDMTAGAIDGAIDGAAAAAARSSRPIVWLDAPVRERDMRHFVGGVNARVVAPPSKIKGYMLSYGWSDVCRIIWTGPFSSAERDDQGEETKMETETETALLEQGWTQLRSDLETASRDRVNIWRMKVVVIALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BU79</accession>
    <name>A0A0D2BU79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dipeptidyl-peptidase IV</fullName>
            <ecNumber evidence="5">3.4.14.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_07619</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="5"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235050.1">
        <property type="nucleotide sequence ID" value="XM_016381948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BU79"/>
    <dbReference type="STRING" id="91928.A0A0D2BU79"/>
    <dbReference type="GeneID" id="27334702"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07619"/>
    <dbReference type="HOGENOM" id="CLU_006105_0_1_1"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="19">
        <location>
            <begin position="228"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="18">
        <location>
            <begin position="685"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW14834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="909" mass="102841" checksum="2816C78474F6D1E4" modified="2015-04-29" version="1">MTRSAMGLVEEGERLIKEGHEWEGTSRREDGDRSRSSEESVTTVSTTSLVLENLNSVYATKEAEEPVKYRDNDSDPELPKFTDKNYTDGNRMSKGLRKAIWVVSIIAIVGWAFALFIFLSTARYKHASTMAYDHETPTKSSGKKVSLDQVLSGQWQPRYARIEWTAGPDGEDGLLLEANQPDKPFVVVEDIRSQTSASSNAAKDKTLVESGWFNVNGEQMWTDNFWVSPDHKHVLLMSKREKVYRHSFLGVYFILDVETQAVQPLDPAYPDTKIQLTQWSPNSDSVVFTRDNNLYLRALSSAKVTQITDDGGPEYFYGIPDWAYEEEVFGTNTATWWARDGQYVAFLRTNETMVPEYPVQYFLSRPSGKRPIEGLENYPEVKEIKYPKAGAPNPVVDMLFYDVAKQQIFTIDIEGGFPDDDRIIFNIVWADNGKVLVSESNRISDRVRVVLADVTSRTGQTVRTVDLKDVDGGWFEPTQFTKYVPADLANGRPEDGYVDVVISDYGTHLAYFSPLNSSSPIMLTQGDWEVDGGPAGVDLKNNLVYFVAAKEAPSERHVYSVKLDGTDMTSLVPSNETAYWASSFSSGAGYVLLTYQGPSIPYQKVISTPANTENIEQKLEDNKALAKMASEHELPHQIFQNVSIDDYTLSLVERRPPHFDSSKKYPVLFYLYGGPGSQMVNRRFHVDFQSYVASSLGYIVVTLDGRGTGFIGRKARTIVRNELGKYEAHDQIAAAKMWAAKDYVDASRMAIWGWSYGGFMTLKVLETDAGETFKYGMSVAPVTDWRFYDSIYTERYMRMPQDNPDGYDRTAISNVTAISQNVRFLIMHGVADDNVHMQNTLTLLDKFDLAGIENYDVHFFPDSDHSIYFHNANHVVYDKLSKWLISAFNGLWYETNDPKPMAEEFQEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BUM1</accession>
    <name>A0A0D2BUM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_07721</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235150.1">
        <property type="nucleotide sequence ID" value="XM_016382048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BUM1"/>
    <dbReference type="STRING" id="91928.A0A0D2BUM1"/>
    <dbReference type="GeneID" id="27334804"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07721"/>
    <dbReference type="HOGENOM" id="CLU_015166_16_2_1"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="121"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="222"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW14934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32946" checksum="7323FB84526DC6B8" modified="2015-04-29" version="1">MADGVEAIEAKEAIEAENASWVRTVKDLSAGAAGGVAQVLLGQPFDIVKVRLQTTSTYPSAAACASSILQKEGPLAFYKGTLTPLIGIGACVSVQFGAFHYARRAFEEQNLKRNPSASTELSYGQYYAAGAFAGLTNSVLSGPIEHVRIRLQTQPHGADRLYSGPLDCIKKLSAHEGVLRGLFRGQAVTLWREAQAYGVWFLTFEYLMAQDMKRNNVKRSDISSPKVAFYGGLAGEALWIASYPFDVVKSKMQSDGFGKDQKFKTMRDCFSQTWRAEGMRGFWKGIGPTLARAMPVSAGTFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BW10</accession>
    <name>A0A0D2BW10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_05490</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235660.1">
        <property type="nucleotide sequence ID" value="XM_016379833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BW10"/>
    <dbReference type="STRING" id="91928.A0A0D2BW10"/>
    <dbReference type="GeneID" id="27332573"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05490"/>
    <dbReference type="HOGENOM" id="CLU_003041_3_1_1"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="288"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="489"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="723"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="638"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="725"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW15444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="793" mass="88067" checksum="B058A94126578F15" modified="2015-04-29" version="1">MVRSREEDEFVLTLSDNDDAASIESESDAAAPNLKRKRNEVKNGGKSKRQKTQGKAKQPLASSPPESESDEDHGVDDGAIDSEFEFDVAANPVQEELEEFDGWGEGSKVNGRGSQKGVDIDELIARRSVKKQQKPKADSVGEAESTSEEEDETEEDEDDIQIPDFEDDELVADDTFGAGAVSEDDEQSSSTDDESGDDASDNDSVASPVAHPDDLASDHEDSDAESQASADAEEQAKRAAFFAPEEKVKQADLKSVSSFQQFSLSRPILRGLASLSFTAPTPIQTRAVPVALQGLDVVGSAVTGSGKTAAFLLPILERLLYRPRKVPTTRVAILMPTRELAVQCYNVATALARFTDITFAQVVGGFSLREQENILKKRPDVVIATPGRFIDHMRNSPSFTVENIEILVLDEADRMLETGFEDELNEILKTIPKSRQTMLFSATMTDSVDKLVRVGMNRPVRLSVDAKKSTTAGLTQEFVRLRPGRENMRLATLCVLCKNAFTERVIVFFRQKKEAHRVRIIFGLLGIKAGELHGSMTQDQRINAVNAFREGRTTHLLATDLASRGLDIKNVMTVVNYEAPQTHEIYVHRVGRTARAGRSGRSCTIAAEPDRKVVKAAVKSAREQGAKVVSRIMDVKEVDAMRSQIEEMEKDIEDILREEKEERQLAQTEAEITRGENRIKHEAEIMARPKRTWFESEKDKLDAKKRGLLELNGPNGVVKVKTERKKLSNKDKKKLDLHRERVDGKMWKKGKGSEEAAIRERRERKKKNKGGGVGGKTAAGKVKNKNKNMKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWE0</accession>
    <name>A0A0D2BWE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">sterol 22-desaturase</fullName>
            <ecNumber evidence="6">1.14.19.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05612</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.41" evidence="6"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235780.1">
        <property type="nucleotide sequence ID" value="XM_016379953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWE0"/>
    <dbReference type="STRING" id="91928.A0A0D2BWE0"/>
    <dbReference type="GeneID" id="27332695"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05612"/>
    <dbReference type="HOGENOM" id="CLU_023517_0_0_1"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW15564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="533" mass="60849" checksum="F498762837D990EA" modified="2015-04-29" version="1">MDIVANRTAFTSPLADAQLKIQAADASGFVGRIVAQLNVWTVLFTILALLIAYDQCSYQYQKYGIVGPAWKLPFMGPFLESMRPEFKKYKQKWESGDLSCVSVFHKFVVIGASRDTARKIFNSPAFLKPTVVDIAPKLLRPTNWVFLDGREHVDYRKGLNGLFTRQALEAYLPGQEEVYSRYFKIFVNESKENNMKPKAWMPILRELMTAVSCRTFVGHYMSDQVVKKIAEDYYLITASLELVNFPFIIPYTKTWYGKKACDMVMDEFAKCAAKSKVRMAAGGSITCTMDAWIKQMQDSAKYRERIARGETVDSSEKPAQVLREFSDMEISQTMFTMLFASQDATSSACTWLFQIMADRPEILAKVREENLALRGGDRNKPFDMDMLESMVWTRAVVKETLRYRPPVIFVPYVAKKDFPMTENYTIKKGSMVIPALWPATHDPEAYPDPDNFVPERWITGDADKQVKNWLVFGTGPHHCLGQTYAQLNLMAMIGKASILLDWVHEPTAISEDIEVFATIFPQDHCRLTFTERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0H4</accession>
    <name>A0A0D2C0H4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Choloylglycine hydrolase/NAAA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237350.1">
        <property type="nucleotide sequence ID" value="XM_016378673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0H4"/>
    <dbReference type="GeneID" id="27331408"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04325"/>
    <dbReference type="HOGENOM" id="CLU_045206_0_1_1"/>
    <dbReference type="OrthoDB" id="63199at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01902">
        <property type="entry name" value="Ntn_CGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052193">
        <property type="entry name" value="Peptidase_C59"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35527">
        <property type="entry name" value="CHOLOYLGLYCINE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35527:SF2">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239425" description="Choloylglycine hydrolase/NAAA C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Choloylglycine hydrolase/NAAA C-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="357" mass="38917" checksum="A384450F76D043B9" modified="2015-04-29" version="1">MFASIFTLCLPLLGNLITHASACSRVTYNSGPGDNNRIIVGRSMDWFVATNASIWAFPPGMNRSGNAGPNSLNWTSKYGSVVTAMYYAATVDGINSEGLTGNFLYLSDSDYGARNDAVPGLSVGAWLQYFLDNYATVDEAAKDLYTPEGRQKFQIVTTEIIPGTPSVGHVSLADASGDNLILEYLDGVLTVHHGKQYTVLTNQPPYDQQLAINAYWLPIGNDSLPGTRRPADRFARLSYYNNVTASANDQEESIAVTASMIRAVSVPFSPSLPGQPNVASTLWRTYSDTRALRYYWESSLAPMFFWINLGSMNLTSNAPVRMLALQNVDPETRVGNMDNDFVDSAPFEFLTSAGGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C254</accession>
    <name>A0A0D2C254_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine-protein kinase SSN3</fullName>
            <ecNumber evidence="6">2.7.11.22</ecNumber>
            <ecNumber evidence="5">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Cyclin-dependent kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Serine/threonine-protein kinase ssn3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">PV08_04934</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="6"/>
    <dbReference type="EC" id="2.7.11.23" evidence="5"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237955.1">
        <property type="nucleotide sequence ID" value="XM_016379278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C254"/>
    <dbReference type="STRING" id="91928.A0A0D2C254"/>
    <dbReference type="GeneID" id="27332017"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04934"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="56"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="438"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KIW17739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="471" mass="53122" checksum="FBDA9F4476A95C84" modified="2015-04-29" version="1">MVSRLDSLKSRSASTTPDSELQLEVLLIHVAESSRGLDKKQSGNNYTSRVKVSQKYSIIGFISSGTYGRVYKAMERNPRSGTSTPDGAAPTKELFAIKKFKPEKEGDNVQYTGLSQSAIREMSLCTELSHPNLIHLAEIILEDKCVYMVFEYCEHDLLQIIHHHTQPTRRPIPATMIKSILFQLLNGLYYLHQNWVIHRDLKPANIMVTSSGHVRIGDLGLARLFHKPLSSLYSGDKVVVTIWYRSPDLLLGARHYTPAIDMWAVGCIFAELLSLRPIFKGEETKMDSKKTVPFQRNQMAKIVEILGMPRREHWKGLVDMPEYPQLQSLVVSRGGMPGSLYQSSQGSINRQSNAGSGLENWYTNCLRHASYPSDKSPGQKGFQLLSELFEYDPDKRLTAEQALHHEYFRSTDEGPNKGKIWVSNNCFEGLNEVYPHRRVSTESNDINTSSLPGTKRGGLPDDTLLPAAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8S4</accession>
    <name>A0A0D2C8S4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240160.1">
        <property type="nucleotide sequence ID" value="XM_016374884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C8S4"/>
    <dbReference type="GeneID" id="27327602"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00519"/>
    <dbReference type="HOGENOM" id="CLU_078321_0_0_1"/>
    <dbReference type="OrthoDB" id="5409186at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250456" evidence="2">
        <location>
            <begin position="20"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="314" mass="30725" checksum="9EDDB81C01F17FD5" modified="2015-04-29" version="1">MLFTKAALCLSSLVVLVSAQEPDAASLKGLDVGRTRTPTSTNRLMTRSLDKRCTGSCTECFGAGYTLCPGSSIFCYLPGDEYYGLDSCSSGDTGTGSDSATSTAAASPSSSTSTSTSGGTDICSQVGATCVSCFGSGYMECSDGYHCYNPNDPDYDTCPDDTTGGSDGGSGGTTDSSCAAKWGAGNIACGSTGCYNPDEGEICCEDGYYCAAGTTCSSTVGKCCAAGSTSSGCSGSDGSGLLSSASSFTTTSDFPLTSSSTAGLFGAVASATTTAAGAATTSSVLVDSDPGSGAHAVNVGKGFLVVAGVGALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C988</accession>
    <name>A0A0D2C988_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240355.1">
        <property type="nucleotide sequence ID" value="XM_016375079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C988"/>
    <dbReference type="GeneID" id="27327797"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00714"/>
    <dbReference type="HOGENOM" id="CLU_030082_0_0_1"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="508" mass="56281" checksum="D49FF3CCAAE4DEC7" modified="2015-04-29" version="1">MSSAQDADLMDIDIDMDLDLDDHGPALDEELDLEEGEEPSFVPSGARVQDTSALIPAIYTEDPALEPQWNKVHIRGVDEMHTNDILGFVHDHFSEVGDNVHIQWIDDTSANICFKDNEMAKRAQLAFVATPITEDQLVNAPFELRAAKPLASRPASMLVVRVAQQGDRKKKNARDASRYYLLHPDQDPTERMRRGFAESRAEAGDYRRRRFDDREMYRRRRDNNDDDGKEFTANMYDDAPATDTEAAGRGRDLFSRVSKGRRRSASPSRRTRNSDEIDISDSEDDTRTRRRGYRDRNDRNPRSNAGKELFGSASAPPKGGGGLHSDRIELFPNKGPDTDAQMSIEPNTASSSRPATDPANSRANAAAAKRLKADLLSAAQTSPRSNHRRSHAMDAKNEEDLAQRFARKSISIDSTKSFKNGGLANAGIELFPSANSNGGGLSIKGSAGGDGGFSIKGSGGLSIKGRAEAKELFPNQYQRESGRNEGKELFDQPVREKRVRRRAGDLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAH1</accession>
    <name>A0A0D2CAH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240775.1">
        <property type="nucleotide sequence ID" value="XM_016375499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CAH1"/>
    <dbReference type="STRING" id="91928.A0A0D2CAH1"/>
    <dbReference type="GeneID" id="27328217"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01134"/>
    <dbReference type="HOGENOM" id="CLU_093897_0_0_1"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="149" mass="16152" checksum="8BC8E5D24C707721" modified="2015-04-29" version="1">MGAGQSKDESTKHVFTSDTPIQFSQELIDSLQASSETNSTRAKTLELHIAQRVAAELEKIKQHESSALEEARKKIAAASAGTGSAESSPSDHSLLQIPSISPKDLLESGEEKDRKAQTSAKVQQEIEKLKQTLSQRKILKELPGEVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCF2</accession>
    <name>A0A0D2CCF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase SUV3, mitochondrial</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_01759</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241395.1">
        <property type="nucleotide sequence ID" value="XM_016376119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCF2"/>
    <dbReference type="STRING" id="91928.A0A0D2CCF2"/>
    <dbReference type="GeneID" id="27328842"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01759"/>
    <dbReference type="HOGENOM" id="CLU_010647_1_3_1"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001549">
        <property type="entry name" value="SUV3p ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="374"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="724"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="726"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW21179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="778" mass="86697" checksum="1E64E1B8ED8FEF4F" modified="2015-04-29" version="1">MLTRSTRPSQCVFCSFRALVPDVPKPAYNIHRGFRTSNAQCRNGSKPSKPAKPSRPSRPSRPGTKFRPSFNSGYASGRFQLRDGNAEDLGSHQWLEKRVRKALVELKEDLTSTEASPESNLSQMEALDPGGIHWESYTKRLVEILQSPGQALTEQEERLFTDIGKAQSTSQKNLQTNLHFGFIDFVLTENVKNGTMSNHVLTDLRYPTEWYTAARQIQRNVHLHIGPTNSGKTYNALKRLDEQRNGFYAGPLRLLAHEVYSRFKAKGAKCDLVTGDDIRREEDSDVALYASTVEMVDVSKKVDVAVIDEIQMIASPDRGWAWTRAFLGANAKEVHLCGEARALPLIRELCAATGDTLEVHEYKRLNPLKVMTKSLGGDLKNLRKGDCIVTFSVMNIHALKRQIELDTGRHCAIVYGSLPPETRAAQAALFNDPDNDYDYLVASDAIGMGLNLSVKRIIFHGVSRWNGTHHEQLSVSQIKQIGGRAGRYRSAHQDVHNTKSKAGPEANVGLVTTLNDEDLPLVRQAMNTQEVPLKFAGLLPPGDFMEDLASRLPKGTPFEYILRRVTGSAAMHKRFKMCSIRDQSYIARHIEQVRGLSITDRIVFSAAPCSRGSSRLEAVAHALARVIAEKREVDIMDIPEINLEVLEEPISGDRAYLEALEDLHKGLVLFLWLSYRFIANLKDRDVAFYAKSMVEDKINTCLVEFSANPELRKRVLAYKKRMKVPSTPTDGTAMPASTSQLDVGEPEDEQPSRWVLGPSQTDFGDDPKGASTIAATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y453</accession>
    <name>A0A0D1Y453_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_12020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847503">
        <property type="protein sequence ID" value="KIW09736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229952.1">
        <property type="nucleotide sequence ID" value="XM_016386327.1"/>
    </dbReference>
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    <dbReference type="STRING" id="91928.A0A0D1Y453"/>
    <dbReference type="GeneID" id="27339103"/>
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    <dbReference type="HOGENOM" id="CLU_683408_0_0_1"/>
    <dbReference type="OrthoDB" id="4362013at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW09736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="406" mass="44818" checksum="2934BA5F2D6AE4F0" modified="2015-04-29" version="1">MPTTRRTPAIPTTPRRPPSGRARKPSAKATQLIAENDSDLETISVVADGDETLFPPRKGHQETTLEALVKTISELKETIASQGKALRDIQDELKQVKSQNTELQNAVRSLESKLERATTSPTALRSWASVANEGSATQTPAGPTAPANSRQPKKEPQCLRISTKANRTEDEVNGDTLTRNLPIGRAIGLIRQALLKTDKTKEVEVVGVNTTRTGYVVRCKDEQAAATAKTHTEWLQELGNNTKLVKPRYPVVIHRFPTDGIVLPDNEHEFIRQLMEENEMQAKNAQIDEATWLIAKGKPIGYHATLGVWFDTEAAAQEAITHGLVYGQRHMGVSAYDPEKKKCYNCREPGHFQKDCPKPKRCHLCNGDHERRHCPSNEGGRSGNRQAPEHLSIGEESGLTQANGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8F0</accession>
    <name>A0A0D1Y8F0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase PSR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231487.1">
        <property type="nucleotide sequence ID" value="XM_016384885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y8F0"/>
    <dbReference type="STRING" id="91928.A0A0D1Y8F0"/>
    <dbReference type="GeneID" id="27337654"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10571"/>
    <dbReference type="HOGENOM" id="CLU_020262_2_0_1"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="385"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="559" mass="60184" checksum="A6B6199507C00719" modified="2015-04-29" version="1">MSGSAATQPSSGASAQDPNPTDSSTAPPAASSHETQDNETMTDKVNQQPSLVTIPSRTSSHIKSTEKNPTAPAPSTATNDTPSFPRRASKRSLLSRSRNNSRSSRRSAKASRADDASKEPVPPLPQSPASKTSQKARGGFLAILNCCIPHEPPGDNKSDDPEVAAKKIKIQPPPQRTVSRPQDEVEVAENEKPIAGKPSTDQSVIPGRAVEGENPAISEKQAAEGSRPRISRELAYHEKAPLPSETTAIAVRASGGKSGFGSEGAASQQNIKTSTVSAPEKTSNPDVNIIAATPIEPEHPRKGPEADSADASDVDMDEAPPAVPEVDPEPVDEPIQPAELQPQVPLPPPPPLSKRQEQVSPNDIPPVPDAALEKQTWLLPPAKAPLKGRKCLILDLDETLVHSSFKILNQADFTIPVEIEGQYHNVYVIKRPGVDQFMKRVGELYEVVVFTASVSKYGDPLLDQLDIHKVVHHRLFRESCCNHQGNYVKDLSQVGRDLKDTIIIDNSPTSYIFHPQHAVPISSWFSDAHDNELLDLIPVLEDLAGPQVQDVSLVLDVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y939</accession>
    <name>A0A0D1Y939_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoketolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231697.1">
        <property type="nucleotide sequence ID" value="XM_016385095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y939"/>
    <dbReference type="STRING" id="91928.A0A0D1Y939"/>
    <dbReference type="GeneID" id="27337864"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10781"/>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_1"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02011">
        <property type="entry name" value="TPP_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003617">
        <property type="entry name" value="PRK05261.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003619">
        <property type="entry name" value="PRK05261.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF0">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="608"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="90951" checksum="B6D0261FFAE023B4" modified="2015-04-29" version="1">MAPVAETDVSIESISPYGKARSTVKENPLSDEELKLTDDYMRASLYLCLGMLYLRHNPLLKEPLKVGDLKARLLGHWGSDAGQIFAYVHMNRLIKKYGLDALFISGPGHGAPAVISQSYLEGVYSEVYPDKSEDEEGMRKFFKQFSFPGGIGSHATPETPGSLHEGGELGYAISHAFGVVFDHPDLIAVTMVGDGESETGPLATSWHSTKFLNPITDGAVLPILHLNGYKINNPTILARVSHKELESLFYGYGWTPYFVEGSDPESMHQAMAATLEKCVLEIRAYQKKARESGKAFRPFWPMIILRSPKGWTGPRTVDGHYLEGFWRSHQIPLPKVASSQKDLKLLEDWMKSYTPEKYFTEDGKLIPELKKLAPEGNARMSANPVANGGLIKKPLRLPDFRGYKIDVKHGGTANAPSMSNMAVFLRDVIAKNQTNFRLFGPDETESNKLGGVYEAGKKVWMGEYFEEDADGGNLAPEGRVMEMLSEHTCEGWLEGYVLSGRHGLLNSYEPFIHIIDSMVNQHCKWIEKCLEVEWRAKVASLNILLTATVWRQDHNGFTHQDPGFLDVVANKSPEVVRIYLPPDGNCLLSCMDHCLRSSNYVNVIVADKQDHLQYLDMEAAIEHCTKGAGIWDWASNDQGQEPDVVMASCGDVPTHESLAATALLREYIPDLKIRFVNVVDLFKLIPNGDHPHGLTDTEFSAIFTDNKPVIFNFHSYPWLIHRLTFNRKGSHNLQVHGYNEKGNIDTPLELAIRNKTDRFSLAMEALDKIPGLGNKGSSAREKLLNEQIKCRNLAFHEGIDPEYIRNWVWPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDP0</accession>
    <name>A0A0D1YDP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_08328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233357.1">
        <property type="nucleotide sequence ID" value="XM_016382654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDP0"/>
    <dbReference type="STRING" id="91928.A0A0D1YDP0"/>
    <dbReference type="GeneID" id="27335411"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08328"/>
    <dbReference type="HOGENOM" id="CLU_012970_1_0_1"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000302">
        <property type="entry name" value="MFS siderochrome iron transporter MirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF50">
        <property type="entry name" value="MFS SIDEROCHROME IRON TRANSPORTER MIRB (AFU_ORTHOLOGUE AFUA_3G03640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW13141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="66150" checksum="0DC6BA58D5A5FE98" modified="2015-04-29" version="1">MRITDSLKNRLGKAGELSHDPSNADVNMADVDRHEITEQPKGDVETSSVQKPQEEAPAEDAQAGVQAMEATSMVWTKRSLIAVFICIWTVYLLNAFQSSTIGNFAPYVTSDWDSHSLLTVIGVVSSSMTAAVFIPLAKALDVWGRAEGYLTMVVFCELGLILMAVSHNLATYCAANVFYSVGFTGLIYSIDVVTADATALKNRALAYAFTSSPYMISAFAGSYASDKMLADIGWSWGYATYAFITPVICAPLYFLLRYNLNKAKRQGLLKERAASGRTLAQSVWYYTLEFDVLGIFLFASGLVIFLLPFNIATTAPDGWATGYIIAMIILGFFLLVAFGLYEVFFSPVPFMKFKFLSDRTLMGACVLQLAYQISYYCWASYFTSFLQVVNYLTVAEAGYVNNTFNVVSGFLLFGVGFGIRKTGYFKWLLWIAVPMYILAQGLMIYFRNPDPYVGYLVMTQVFISVGGAVFIICCQLAVLAAVDHQHVAAALAMLNVTGTTGGSIGYTISGTIWTNTFEKALKMYLPADALPDLDTIYGDFDTQLSYPRGSPTRHGIQRAYAYAQTRMLAAGTGFMVLAFVGVFMMRNINVSKIKQTKGNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNL1</accession>
    <name>A0A0D1YNL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236902.1">
        <property type="nucleotide sequence ID" value="XM_016378225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNL1"/>
    <dbReference type="STRING" id="91928.A0A0D1YNL1"/>
    <dbReference type="GeneID" id="27330957"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03874"/>
    <dbReference type="HOGENOM" id="CLU_009665_14_0_1"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF8">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="23"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="611" mass="68844" checksum="DE0A3C35BC022DF4" modified="2015-04-29" version="1">MPHSTVVNGVSDGTQHTSPTVIETPLLIVGAGPAGAALACFLSHPPYSMTGIMIAAAPTTSDTPRAHITNPAALECLRDIGLEKQCLSQAVEGDCMTHTRWCHDMTGEEYGRIYSWGNDPKRRGEYDSATPCHHVDLPQTVFEPIVVQRAAAEGWDVRFKTSLLSFEKEADGKILSRVRDDLTKIEYLIRSDYLFGCDGARSQVIRELKIPMIKKPGQGLALNVLVKVDLSDFVEARKGNLHWVFQPDQEYPDFAWSGLIRMVRPWNEWMFILFPKPGAEWKEPTMEQYTQRCKEIVGRDDLPVEVLGVSKWYINEIVAEYYSEGNVFCLGDAVHRHPPFNGLGSNTCVQDAFNLAWKIKYVSQGFASPSILDSYSTERQPVGLGVVTRANQGIRDHVPVWKEMGLMEDTVEKRMAILNSLKDATPEARERRKRVNAAIEGTSHEFHGIGVEMNHRYESSAVYLEDEIKAGREKPEWPEDPILQHKASTYPGHRLPHAWLNKTMPDKEHTSTLDLAGHGSFCLITGIGGDKWIEAAKKVGTELGLDINAYSIGWGQEWVDVYRDWEQRREIEEDGCLLVRPDRFIAWRSMEMASDSEGKLREVLKKVLGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNV7</accession>
    <name>A0A0D1YNV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_04001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237027.1">
        <property type="nucleotide sequence ID" value="XM_016378350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNV7"/>
    <dbReference type="GeneID" id="27331084"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04001"/>
    <dbReference type="HOGENOM" id="CLU_940205_0_0_1"/>
    <dbReference type="OrthoDB" id="10304598at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="293" mass="33415" checksum="714E2DEE8BEB87E9" modified="2015-04-29" version="1">MESPEQTSTSAAQTRLAEKYQMSKIALLAMLWEQVREPSHIGALASHLERICLDTTWHPAARFPGIHKFCCNNYDPRFGVDDARRVLREIDSKLSGFSEVYNAADMHILHDILTFATVPFRPEHVLGLAIYGCAEIRHREPSRELVDFGTLANDLVVTVRSIVDTRGPDECRYIAGNQHTSLHILTQEVSRHMPYHADMRELCGFLEEIDDAGCQGMFQKAFSKFGQAVFAGVGFIALAGMMDQLCLGPQVEGRPRLEKIFKEEQRATYERDQEARRLYLQAHRDFVRRFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRG6</accession>
    <name>A0A0D1YRG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238067.1">
        <property type="nucleotide sequence ID" value="XM_016379390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRG6"/>
    <dbReference type="STRING" id="91928.A0A0D1YRG6"/>
    <dbReference type="GeneID" id="27332129"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05046"/>
    <dbReference type="HOGENOM" id="CLU_014019_1_0_1"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="66001" checksum="447E4C03CC05A0E7" modified="2015-04-29" version="1">MGMPGGVRPIVLVSGDVSAVIPKPAAQSISSPFKTSQAETVGIPVLGLMGVEEVHGVGPTGLFRLHQLDCAWKTPEPAAHQARHENAPQSGVGNRASALSATPLDSLGADATNASINSPTQPEPAPVPDRNSRLEDVFDFASFLWSRPTSPFLSELQINHQALDAGGTGHLRTAVSGSMRDQAATQLPFTNDSQVSDAAQLREHFAHSDAPPIIAQIETRSGWTLMRDHFLSMTRSSLMVHYAVSAFASLQLRRGREQGGSSVSYYYDLSETEIAGSVLEHGNKIDILGANVNHVLTALFLLTYIDLVTNKTACAHTQLRRAHRIVSDLDPETLEWPERRLISWYRLLDARAVTAGGEGLFLRDGSDSPEFGRNTPPSNEDAEAVVADMLSKPLQEFFQKTQLFMGRITQIDLWHRSRGTVEDETEVMTIAAQIQKDNHALYRHRPPILDLAVAGSLQAPLLASSLATELTRSARVALANYHASFIHLHRVAYRHLPRTTDVINAMVMIKQTIRHLEAAQTSAESLPVNMLWPLLMWGAEEDCPEERTCILSSIRKMSNNISNASITADVLQSVIERQDACGQRVDIRTVMHEIYNSCFAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVS4</accession>
    <name>A0A0D1YVS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239597.1">
        <property type="nucleotide sequence ID" value="XM_016378027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVS4"/>
    <dbReference type="GeneID" id="27330759"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03676"/>
    <dbReference type="HOGENOM" id="CLU_1510504_0_0_1"/>
    <dbReference type="OrthoDB" id="4109707at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21257" checksum="7E35661094F6AB4F" modified="2015-04-29" version="1">MSRLDPSATLTPAVLRNPYAPMSSISHYSRLSSHLANALARWEQYFQQQVGSDIRALYYFTNVSLMCPNLWELPQLAGYGTDDHLGQQAANSKFNIPDKAIDLAWLVLDNCDKASKSPEYKTSIWLPIILFMSSLVVWKKLHSQPAAELRYGTLRVLSMFKSELAKLPWPCCSEMIPRMTKEDRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZS1</accession>
    <name>A0A0D1YZS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_01399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241037.1">
        <property type="nucleotide sequence ID" value="XM_016375761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZS1"/>
    <dbReference type="STRING" id="91928.A0A0D1YZS1"/>
    <dbReference type="GeneID" id="27328482"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01399"/>
    <dbReference type="HOGENOM" id="CLU_006632_1_2_1"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="267"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="567"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW20821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="633" mass="71307" checksum="E18838323DC70EA0" modified="2015-04-29" version="1">MTSLTRPERPCDYCRRVKQKCIPAPGDSCALCQGRRCTFIEAPPKKKRKQSNQVTDEAEAVSVSPDALRESPQDYSRLPGASLLKHTLGHQHFRTNCYIGSTSFPSRVLLDLTRVQQHDSYRASQSSLDIRRVGENGYFVILPDKDDIIAEQLDLLDKIEAVISPHGPALVDLYFRIVHPSFPILHKDVFLEKHSRSYRELTPACLAAVYMLALNWWSYSIDLADLAKPDITELEKLVSSLMAFDRAAKVSDIQAGLLFLQRPGHDSWRLTAQLVATAEEVGLHRDCSDWQIPEWEKGVRKRVAWALFIQDKWGALVHGRPSHIKADNWEVPPLVLDDFPENVDEDHAEQGSSEVERGILIFMHMSSLTQILSNIIDALFTVQAAMNYPTTVDLLQAVKPLQLQLKSWYTGLPSVLDLGTTQPRKLSATGQLYLAYLAAEVTLHRAIIESDVRRPLEPDLRQITRGAAVMRLRSVIDFLKRLKPEHMQGFWHFASGPSLAIIGTFSLVLLATSTDTIESKDIFSLIAEFRWLLNINSSSADFTKTAIDLLRTNAGLLARFRPRQSTGAKQFGFRDTISRSHEQEQPKRGSGATQSPSEGRASQTDVNDFLSPGIDMSADQNWFYNFEDFELHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0P2</accession>
    <name>A0A0D1Z0P2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241397.1">
        <property type="nucleotide sequence ID" value="XM_016376121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0P2"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0P2"/>
    <dbReference type="GeneID" id="27328844"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01761"/>
    <dbReference type="HOGENOM" id="CLU_009210_1_0_1"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="82723" checksum="6231EF78CEC3EB2C" modified="2015-04-29" version="1">MATSIIDIQRNVILDTIRATSGRDWKVLVLDDQSSRLVYNVTKEDDILNANITNIERIEDRRQTLTDTDAIYLLSPLPHIVECLKADLSRKRYRRAHLIWTSQLPRHLSEEIFRSETRARSIIENRSLNIDFFPREANLITFREPWSFHVLYHPACDALVKNHLDALTQKIVSICVSLGEYPMIRFYKPRDSERHPADVLCYHLASFVQAALDNYARDERNEFPPQTQSTRPRAVLLITARSMDLVSPFVHELTYQAMAMDLLPIRDDEDKITYRNVIRRGQPDQEEKDVEITDKDNLWVSHRHMHMKDLLIELSDAFRKFQANNPQFADTDGQPASINTIKDMLAGLPEFQEGKEAFSLHIDMAERCAKIFADHKLLDVVSVEQSLSTGLDEDQKKPKNLADQLVKLLDDDSIIHEDRVRLLILYILYRHGILRGDIEKLRCHGQLSPVDGEIIYNLITLGARVEKQLKDTTGPPAPLFPPRLKEASISPEEVSLSRFEPALRYMLEDQCQGTLDQTVFPPVKPHLNDPNSQGMGAQTSLRNAGKPTWAQTRSQSNKPRQRIIVFVAGGATYSEARACYEVSRMAGKEVFLATTHMITPKNFLRQVSLLSSGRKQLDLPLDRTQPKLPAWMSEPPPQAQQPRPPGAGVNGSGMRSTTDAMARLNVSGGPRPEKPRPDNGIRPGVGTSPSRPQQPGSAPAPYQNPLAPGRDSASHGKLKKDKKHLGLFKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0W0</accession>
    <name>A0A0D1Z0W0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241492.1">
        <property type="nucleotide sequence ID" value="XM_016376216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0W0"/>
    <dbReference type="GeneID" id="27328939"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01856"/>
    <dbReference type="HOGENOM" id="CLU_010731_0_0_1"/>
    <dbReference type="OrthoDB" id="4149643at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="944" mass="104312" checksum="CE14FE9AF5C6CB3C" modified="2015-04-29" version="1">MVLATVSTLPPASAGLDPSETDPDKIESFEGIVNGTERTVSFFQSGPDSPTDNSTSDLPTAISHSKVANPREHIILEGQSTQPDGKLQRCSPLFTMERSEIGIGMDLNAANTGDGPSRIRQDLQQGRFEIPPLKNQNFDFNAPPTGTHQSPSTPRQLYLSPLRRRFDMSHLLPDRNLPFNLQIMEHVKSWAELGTRIEDDTRRKEVLDHVFEVLQKAWFEALRLGYDPGTPIPESGKRRQRMSVAPTLVKSQHNLHLPPPIARPRQRKDVEPSKLPIFVSGSYKNSQLWGVTAGELEQAGVSENRVRERAIADLSSGDELLQEVLEDLDTEEISKTDWLRTEEVTPLNPLGRNILLYTLFEVQMSRRSLDHLQSLYAQFTTKQQKANTQKRIDEEMKRHNLFLALALEVTDHPGTSSSGSPESEHEGESHLDKQFPDSGVGYSAAGDPLIEAVEKVVALASTPELGQLVCSMSVVLPEHVLDTANTANTDTLSDKERARCALREILQDIQSIQALSSDAEDTAANSKRHLYLQTEIAELEKNVSNNKKLLADLLPGLKDSLPRVDEESHVPVDIEMGGLQDNAEHSLSGEAATRSEPNSGTSLETTSSAGAPTSVQDLEDVDADLMEHPQLGQAKHDHATIVEPCPSALTRTGSSEQNTSSAIPDSSLEAQPVERYSRVPSQGHEESAHVVQERALGQSLVVRMLVCKGFDPTEFTSEKVFEHGGFSYRYTRASSLSERRAMDEYLDSYIRRHRKSPTHGHYDALCHPADPERRTVVHGIWNNKSGGKADGSEWFYDGDGDCQPPAVEYNHKRSAVKSRAEAETASGEEGASDVVEGRPGTLPEREPPRLVNKNFKNVLKIKLKTRPDANIGKRRQMQNNKRRSRAGPLPASPLSRSMTASTTRPPKRARSASAGRRRSKRHAGKQATSTEVDGNTDDEYVPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z118</accession>
    <name>A0A0D1Z118_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sulfite reductase [NADPH] subunit beta</fullName>
            <ecNumber evidence="6">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PV08_01936</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Alpha(2)-beta(2). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="6"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241572.1">
        <property type="nucleotide sequence ID" value="XM_016376296.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1Z118"/>
    <dbReference type="GeneID" id="27329019"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01936"/>
    <dbReference type="HOGENOM" id="CLU_001975_1_0_1"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000085">
        <property type="entry name" value="Sulfite reductase [NADPH] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000051">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.480.20:FF:000012">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01540">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011786">
        <property type="entry name" value="CysI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="807"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00063391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KIW21356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1551" mass="170798" checksum="CD31A37E9A388107" modified="2015-04-29" version="1">MGSVSSPAEAVARIAYLASDVVLSVQPSLSTDSEFSHHLGRFAAANAKSFVSKTVPEIIPVRQNADPLLSAFTPLKAGKLVAATAPSSILLSAVPHLYKLAQYPFVLHVALASPQPDFSEISSIRQCGFSFLQSETLQESQDIALTAHALAIKSGKGVIHFYDPSNSAEDSPISVESRDLVQTLLETGAGARASHSGSEEQTLYASSGRLATVTDLGLPTVPATQTGAASRDLLSHVAAASSTNGTTDVSSSTSSRRDSSAESSVASSVATTVETPVIRPVSATDIFTYVSDIWAVISQATGRSYSAVEYSGPPDAEAALFIFGSTGVFVDVLDSDDVPADLTNVGLITARLYRPWLGSAVLLDSIPRSIKKIAVLEQIRRKTTRWGPSFLDLLSSLSPGAGGQSNISLVQYRLGHIDAATALQALRGIFQNLAPPTTPRKHSRRRGHSQGNFVSIQNLSIGNEVQPTIDSFVPEQPQLENAYLKILDQLFGNRLYIANQLKQKNAGVSATLAASPEYGFGSLLARIERREQFVKEAQQAARSNEFITESPKQWLSRWALNANDSAKANEYASEVLARLANDGSSLSTRLLDNKSFFFKESQWLIGSDAWAYDLGNSGVHHVLASGANVNMLIIDSEPYSERAQADSNRRKKDIGLYAMNFGNAYVASVAVYSSYTQVLQAMIEAEKYDGPSVVLAYLPYNKENDSPLTVLQETKKAVDLGYWPLYRWDPSNEVKGEPSFSLDSERIKRELEDFLRRDNQLTQVMNRHPQFAANLSESYGSEVRKLQKRKAKDAYEQMLEGLYGAPLTILFASDNGNAESLAKRLGNRGKARGLKTMVLAMDDYPLEDLPNEENVVLITSTAGQGEFPQNGRAFWEGIKDAADLDLSNVHFSVFSLGDSHYWPRKEDRIFYNKPGKDLDSRIQFLGGKVLTAIGLGDDQDPDGYQTGYQEWEPRLWQALDVANVEGLPEEPPPLTNEDIKIASNYLRGTIAEGLADTSTGAISASDQQLTKFHGTYMQDDRDLRDERKAQGLEPAYSFMIRCRLPGGVATPSQWLQMDAIASAHGNETMKLTTRQTFQFHGVIKSKLRPAMRAINRALMTTIAACGDINRNVMCSSLPTMSEYHREVHAVSKKISDHLLPSTTAYHEIWLKDDATGEKTQVAGDAVQDFEPLYGPTYLPRKFKITIAIPPHNDTDVYAHDVGLIAIRTKDNQHLEGFNILAGGGMGVTHNNKKTYPRTGYMMGYVPADKAHLVCEKIMLVQRDNGDRKNRKHARLKYTMDDMGNEVFKSKVQELLDPLGIKFETPRPFKFDSNVDTFGWQRDEKGLNHFTFFIENGRIEDTADFPMRSGLVEIAKVHEGEFRLTGNQHLILSNVTDEAKPKIAALMKKYKLDNTQFSALRLSSSACVAFPTCGLAMAESERYLPELITKLEGCLEENGLSQDSIVMRMTGCPNGCARPWLAEAAFVGKAYGAYNMYLGGGYHGQRLNKLYRSSIKEDEILEIMKGLLSRWAKERNQGEHFGDWTIRAGVINETTEGKYFHENTAEVESDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z126</accession>
    <name>A0A0D1Z126_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241582.1">
        <property type="nucleotide sequence ID" value="XM_016376306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z126"/>
    <dbReference type="STRING" id="91928.A0A0D1Z126"/>
    <dbReference type="GeneID" id="27329029"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01946"/>
    <dbReference type="HOGENOM" id="CLU_352671_0_0_1"/>
    <dbReference type="OrthoDB" id="4158700at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="797" mass="91175" checksum="B66D8DA87C87F8D0" modified="2015-04-29" version="1">MATAESSQSGHFKSNADSTVWRLPGIDKDSFYAAALYLHAAAENLETKPFWEASDAFPDERNFLDHLANCFARSKLQDARDHVSATAMVRNKERKTITVYIAKNRSDKQYSPPPSGGKETAIRNENEEFAARLMQWFTSLASQHATSGQLHNDKSHVRSDIFRSMCKSSESRLEYYIARIGDADVELLGTTAELDLVGKSRDGWRKVVPLVERCSQYKDEESQLLNLEAEKAELLAAYARDAGNIRRDADFLALVHEVEAPTLENSVKLKGLAQVVKWINYLGRVFSAFDYFPRFCGSEARQGYVFDYVLLASQEDDWYGTAYMQKMQSWTGNLDLAQERRIPIVVNGRASWEISSVQNIMDSVVHESGNKARVHCEMQLLMYFSQTGVEQCLNYFGCSKKSCWLCWQMIRHNSKHSVRGTHRKLYPRWAFPFNFDPSQPAIAEGLTNAYSEMMATIRDLVINQKPVRSMAPYPQSSALITPPRRSGKRHDPLQDSESGIFSSNPVAVEGKRPVAEVPALLLPGTGRIRQVRQLKVHAYKTDVNDVNSLLYTKSLLFQDQGVTLAFQLANLPASFDMVSSFEDFRQRCWLPTTFKEVKLERINENLGDIRTHPDRKTKLVQTVYALWYRSASSLPANPILLELYRSGQGKDPQKFPWRGDVIIHSVQPQKRQYPSALSTDSSDIDAESCLRTLERYFCGIGADLAVRQEASDTDFAESRYSILEIAKESKEMNRMMVEWSKEMNRMMVEWSKEMNRMMVEWSKERENSMVELSKKTENRMVEVYHRALEKLEAMTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAH3</accession>
    <name>A0A0D1ZAH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230203.1">
        <property type="nucleotide sequence ID" value="XM_016386071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAH3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAH3"/>
    <dbReference type="GeneID" id="27338846"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11763"/>
    <dbReference type="HOGENOM" id="CLU_002173_5_1_1"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000004">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="842"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="711"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW09987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1203" mass="134603" checksum="4D1DF91183358FA3" modified="2015-04-29" version="1">MALPSSHQKGRSVPRNIQTNLTPNEGRQSATDLNRPLPPPPASASIETYEIPSLRRKPVPGQLEPESSKPSHNRSFSHPFPSIFGSKRSEKKHSARGEPEGMSSGGKDTRQEDNKQKSATAEGSAHRGERQPVTGKCMTCDSTVRWPQGLKVFRCTTCLTINDLEFNPEGGATDGANGPGLPRRPSTLSLERTRSLLDRCVKEYLERLLKPNIEHEQAVELQSHSLVEESFLLAGTSPEGALYGELHDELDSPPPSPGPAMKPRSPSESTLTAFKSKSNGQPPFVQGHSSDPFSSSVPTQARPPESKGHDAKSNTPGTTNDIFRMVENYIATSFVGCASLNNSFLTPRPPQESKARTGSSTHQRRQMSEPLSAPHFESDVYLSDLDAKTLLLGDVAENGSWWLGAPGGRTDSTHHRDRSPDKFRGSSSSRNPRINWLELSEWYRCIIYAGEGWEHSWSEMKSHAEGKVQQYCQSLPFESLQRDIIESRIHLHRCLLKMTENLLKRPRQPLKHPEDCRFLLILLSNPLLTPQRLEAGKISSTPLSHPPTSAKPNDDRARGSPARRIPSSGRRPGSLGHHSGIIKRILGLLANSSNEIHQCLVSWFAKYSDGHFQRTVELVGSFVTYRLSRHQKRPVHEAVNPTAGLVPSFSGSGMQHASQIHAALGGRPSSTTGGDNEGKPKLSLYGEDWQVRAAARVMALLFQANIGHAARKKDAHNTHDQRHHSPGQNARHQANRHGQIVPISNFYNTMLDYADLVADFETWETSKSKFTFCQYPFFLSIYAKIHILEHDARRQMELKAKEAFFDSILSRKAVSQYLVLKVRRECLVEDSLRNVSEVVGSGGSEIKKGLRIDFQGEEGVDAGGLRKEWFLLLVREIFDPNHGLFVYDDDSHFCYFNPYCFESSEQFFLVGVLLGLAIYNSTILDIAFPPFVFKKMLASAPLTGDKISSTPRVGHSYTLEDLAEFRPALARGLRQLLEFDGDVEETFCRDFVVEMERYGEIIQVPLCPGGEKRPVTNANRRDFVDMYIHYLLDTSVTRQYEPFKRGFFTVCGGNALSLFRPEEIELLIRGSDEPLDIASLRAVATYEGWPKNEGPPDKQPQVIWFWDFFGRASPGDQRKILTFITGSDRIPAMGATNLIIRIQLLRTKDEVDGLGRAPRTSVERFPIARTCFNTLSLYRYSSRQKLEQKLWTAVTESEGFGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAL3</accession>
    <name>A0A0D1ZAL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230238.1">
        <property type="nucleotide sequence ID" value="XM_016386106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAL3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAL3"/>
    <dbReference type="GeneID" id="27338881"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11798"/>
    <dbReference type="HOGENOM" id="CLU_040908_3_2_1"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237549" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="31"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="319" mass="34689" checksum="E1CBAF59651CDD43" modified="2015-04-29" version="1">MRSSTPSFWFLFLSVHLTLGASVNSTSKRGLIYISTSHSSDDDSIFIQSGSPLSWYYNYSPWPTDTLSGELEFVPMVHGASNAQQDVGTVKTHSNASHVLSFNEPDISSSDGGTNTSPRDAAKAYLDFLAPLREEPYNLKVSLPSTSGSASGLTWLSNFNKTCHSLNSTHGCPFDFIATHFYGPFSGLTSWLGNLHTLYPEAKIWLTEFAIPDTSDTEALAMMNESLPYLDGLDYLERYSWFGSFRSDDANEWTGDGVSMLDDHGKLTSLGAQYLGGQANGFKEGQGQNKEDNGGGAMRDRYSLALMIAGVGVSIVLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZFQ3</accession>
    <name>A0A0D1ZFQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232043.1">
        <property type="nucleotide sequence ID" value="XM_016383420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZFQ3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZFQ3"/>
    <dbReference type="GeneID" id="27336183"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09100"/>
    <dbReference type="HOGENOM" id="CLU_016053_1_0_1"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF461">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="151"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="613" mass="67583" checksum="9F58CDB93A952887" modified="2015-04-29" version="1">MSITMKAGQLGLSTDAPELQELQDGNLRQMSVDGNHPGLRQRLWGLAARMDPTVTFEEYMFWAKIEREMEADEQKKYVETVKNDGKLGGFKAYFLGAPKNVVTEVTPEVDPAAPTEKNGEAGKDLVLNPIAPSQTHDFDAEWRRAARALRTSGWVTVFYLVTTDILGWGQTPYVFANAGYNAAIGVFVLFGVAALCSALMIWQVFLGLDSSRFPVLSFGDPFFRLFGPKTRNMINIMQAFQMFCTVAVIVQGNAQIMSQVNGGHICYIVIALISVFIGIASCGLRALKEVGFLANFAVWINIVSFIIILVCAPKYGPDPTYALQTTLLKVAEPVKTFWGVPPPQYQQQTTDLFAAQFNGIDSIVYAYSGALLFIAFLSEMRHPMDFWKGALLAQIFIMVVYVIFGAVVYTYIGQYAVSTISQVVKPYSVQVASNILALVTGFLAVFMYFNVGMKVVYLHICEEMLHMPPIHTKKGYLFWLILGPMYWVVAWVFSMSVPNFAGITGLIGGLFSLNFTYSIPAIMWVAFVIQKGAVLPGEGFDPYTGETTRHDHGLKRWVRGVRKTWWYSIPGILFACGGLASSGMGSWAAIQGLKQIFGPGGTIQTSWGCAGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJP8</accession>
    <name>A0A0D1ZJP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233223.1">
        <property type="nucleotide sequence ID" value="XM_016382520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZJP8"/>
    <dbReference type="GeneID" id="27335277"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08194"/>
    <dbReference type="HOGENOM" id="CLU_020820_0_0_1"/>
    <dbReference type="OrthoDB" id="3596604at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="586"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="724" mass="80697" checksum="4445A583968128DD" modified="2015-04-29" version="1">MATNQVPVYSALPSNDEDQTQNHELDHVEPTTAPVVQSHPSEERSEPLLVSTTPGDDSPHESPNGSVHQRNTEDSVTQPLSSRPTVAGAATSPPQRLKADRRHSSFSTLKERIRGSLTPSLHNLLEKDSSGEGTSREYRRKTQRNRLLRLTVGEWLNTVILCVMYFGILYAYSQSTAISVPQRRIFNALTTGVSLLLGVNLAASLRSYAKLLRWRILAACYRPLETFDLVMGCDSLLNVFKLVYKAKNHRYKYLPSRTQIFCVLWLLVHLAVTVLVGIIGLNYNLDTSPYKVLFRKGAVNILDLDSLWGGTDDSTYLSDLYEIHLKGLAGINGDEYSLSDLDDDFSYVTWEYDGYPPNYFGDGAGRTVWYFQDLNGDDLSEVAISTRHIQTQANCTGFNVTEGQYGNLSYVVFNDGDKEVNRSLPAVPGYGSLMTVAHMNSTCGERCTNVEGFQALSDLWSISEAVYFTCTNTVGHPVDPKVKLSSNYSVSDQVARMLAGAIGWDKMTPTRQKDGTLVQYQIYQNITTVGFNGWVDQPDADTMGDIISSFTTGLIATLDASQDPDYRENVDDGRQPIPAQVLQVTWRYAGTILAIIPFIHCCTLVTVILWANKAIIKDDSHLAISKVYHTFLNQLGEQGCLLRGDQIVQVLANPDVAYGWRESNEHDGAMHVDVFQKGRDQPRAEKPFVEGWYDGNSRIPLVNGFGNAMGLSRRYRDFDAADYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQ90</accession>
    <name>A0A0D1ZQ90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235163.1">
        <property type="nucleotide sequence ID" value="XM_016382061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQ90"/>
    <dbReference type="STRING" id="91928.A0A0D1ZQ90"/>
    <dbReference type="GeneID" id="27334817"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07734"/>
    <dbReference type="HOGENOM" id="CLU_009539_2_1_1"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000046">
        <property type="entry name" value="dnaJ homolog subfamily C member 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="212"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="62013" checksum="1DD5F3025208AACA" modified="2015-04-29" version="1">MGQRQSTDNATQEEQPPAKADYYDLLGVERTATDDEIKKAYRRKALELHPDRNYGNVEAATALFAEIQSAYEVLSDPQERAWYDSHRDILLRGDAAAGADATDFSYNIRMTSAEEVLKLMMKFNGRLDFTDAPSGFYGGLNDFFKQLAKEEDIACQWEGQDYMDYPEFGLKDDDYEDTVRPFYASWNGFATRKSYSWKDQYRLSDAPDRRIRRMMEKENRKLREEAIQEYNEAVRSLVAFVRKRDPRVQNNQKSEAERQKALREATAAQAARSKAARLAKMEEMDTAAIPEWARSRPSHDELEGGFSSESEVEEHAYDCVVCDKTFKSEAQYMSHEKSKKHIKMLKQLQKEMRAEGRALDLEVENSAPEVEVEVPGEGEARPLDATDEPVDLNVDGEDFSDGVAEQSDVDAATQVKGTSGGSEETEDDSDDDYAARSDIEQRIAGGSVSGTSSKIAGISLEDTPPETSEMETATQRQPKMGKAKQKKARKAAQKAADPTDKVGSMLQCAVCQAEFPSKNKLFDHINKEKHVAYKTELNQAKGSKSTRGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQT9</accession>
    <name>A0A0D1ZQT9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235383.1">
        <property type="nucleotide sequence ID" value="XM_016379556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQT9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZQT9"/>
    <dbReference type="GeneID" id="27332295"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05212"/>
    <dbReference type="HOGENOM" id="CLU_007207_0_2_1"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF107">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="42"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="208"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="405" mass="43515" checksum="B16E7D13870E77A8" modified="2015-04-29" version="1">MALKNQLVVQPFSEDQPAPLLSYGLPYHEACRFHVDSTWTCKRVYLLLSASLTKNSDVRKRMQKALGSKIVGERVGMKPHTLWSEVLEVVKDMRSREADCIISLGAGSLTDAIKLIAWAEANGVHDENDLSKLADRDSPGYASLTPPTIKTIAVPTSLSGGEYTSFAGATNDRTFKKVLFAPPVQNPGLVVLDPEVAATTPSRLFLGSGVRAIDHCVETMCSLNSNEKGDQTAIHGLRLLVPALLAYHKEPSNLAAIHDAQLGAAEAMKTGVYVPDKGGSHAIGHMLGPLGVAHGETSCILLPAVCRYNAVKGANTQQQERLATVLLQISEVQSLVSGSQKDLASIIEALVQALGLPRTLKQVGISRDVFGTLAENTLSDMWAKTNPVPLVQKEQVLDILEMVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZSW2</accession>
    <name>A0A0D1ZSW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236108.1">
        <property type="nucleotide sequence ID" value="XM_016380281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZSW2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZSW2"/>
    <dbReference type="GeneID" id="27333025"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05942"/>
    <dbReference type="HOGENOM" id="CLU_011226_14_0_1"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="111"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30787" checksum="EF1A3D708ED4BC1D" modified="2015-04-29" version="1">MTTTTTSSSTSSAQEQQKALITLYTTQTPNGIKISIALEELGLQYEVHKHDFVTRTQKEPWYLAINPNGRIPAITDTLATGEQINVWESGSILKYLVEQYDPEYKLWYKPGTKENYELFNWLFFQIGGLGPMQGQMTHFKRHVVEPIPYAIERYTNETRRLYTVLEKQLGSSGSGYILSKFTVVDICFWAMAAASGWAGIDLDEFPNVGKWYGRLLDRPGVQRGMNVPEPHPVQALMDDKTGEKAKQFEEYSRSWVLLGMKRDAEALNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWQ2</accession>
    <name>A0A0D1ZWQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237323.1">
        <property type="nucleotide sequence ID" value="XM_016378646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWQ2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZWQ2"/>
    <dbReference type="GeneID" id="27331381"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04298"/>
    <dbReference type="HOGENOM" id="CLU_065618_1_2_1"/>
    <dbReference type="OrthoDB" id="2260257at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238036" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="32"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="233" mass="22391" checksum="8AA9BEFBDBEBB1D8" modified="2015-04-29" version="1">MRFLSTAVAALCATVVAAQNNAISIPAGQSTLDVTAGQPLTIQWTDPSSGTVTIKLQQDPITPDGGITLASGVPASDGTATLDIPPADEVNSHLYTIEIIDDTDTTNINFSPNFGIQGATGTGVASASTASSTGTASTGSATGSSTASASNSTSTDSSSTSTESSAATTSGSSSSSSSESAAASTTSSSGSSATSSSASPSETTTAPDSNSGATGLKVQSGFLAMVVGAIAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZY44</accession>
    <name>A0A0D1ZY44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237753.1">
        <property type="nucleotide sequence ID" value="XM_016379076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZY44"/>
    <dbReference type="STRING" id="91928.A0A0D1ZY44"/>
    <dbReference type="GeneID" id="27331814"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04731"/>
    <dbReference type="HOGENOM" id="CLU_020336_7_0_1"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="321" mass="36576" checksum="6EA5EB109651E343" modified="2015-04-29" version="1">MPTFKVSRGFEYSYIIRRPVSAPKGWLLFLHGYPSIAHEWHYQLDHFHNAGYGVIAPDLLGSGHTSRPAEVEAYLYKDMAKDVVEILDHEAIDRVFAVGHDVGSLLLARLAVYFPERVEKLGFVAVGYRPPGAPVSVDRMNEMTAKVIGYPAFGYQVFFTRNPDAEVILNQHKESLLSLQYAQDPSLWKDHMCPVGAVEEWVLADRQAAWGEFLTEEDHRVRREETADELGGLPTLAWYKAAAWNLNYEVEKDLAEEAKYLHQPTIYITCANDYIAVPRAQLPQMTPWVPNLEVKELDTGHWAFLQRPEVVNEALEAFFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5K7</accession>
    <name>A0A0D2A5K7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_00602</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240243.1">
        <property type="nucleotide sequence ID" value="XM_016374967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5K7"/>
    <dbReference type="STRING" id="91928.A0A0D2A5K7"/>
    <dbReference type="GeneID" id="27327685"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00602"/>
    <dbReference type="HOGENOM" id="CLU_037430_0_0_1"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="39"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="358"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW20027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="441" mass="47757" checksum="7AAEBACA4E1CD660" modified="2015-04-29" version="1">MYKLGRRSLGPALKAVRDAPVRSSIQQRRNLSIHEYLSARLLKSYGIGVPDGEVAKTPQEAEAIAKKISGDDMVIKAQVLAGGRGKGTFDNGLKGGVRVIYSPTEAKMFAEQMIGHKLITKQTGARGRICNSVYICERKFARREFYLAILMDRATQSPVIVASSQGGMDIETVAKETPDAIVTTPVDINTGVTDEMARNIATQLGFSEQCIEDAKNTIQNLYKVFMEKDATQIEINPLSETSDHQVLAMDAKLGFDDNAEFRQKEVFSWRDTTQEDADEVKAAESGLNFIKLDGDIGCLVNGAGLAMATMDIIKLNGGSPANFLDVGGGATPEAIKEAFELITSDPKVTAIFVNIFGGIVRCDAIASGLIHVVQQMNLRLPIVCRLQGTNMEKAAELVNNSGLKIFSITDLQDAAAKAVDFSKIVKMARDIDVGVEFTLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5Y1</accession>
    <name>A0A0D2A5Y1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240408.1">
        <property type="nucleotide sequence ID" value="XM_016375132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5Y1"/>
    <dbReference type="STRING" id="91928.A0A0D2A5Y1"/>
    <dbReference type="GeneID" id="27327850"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00767"/>
    <dbReference type="HOGENOM" id="CLU_012494_3_2_1"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="162"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="322"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="506" mass="57994" checksum="00E4C4296561E6A5" modified="2015-04-29" version="1">MSPSHSPPRPEEHSSTESYDMTEAKDFARSKSPDRLRVPKSHSVTFSNIAEFQSASNVDPPETMLAETFTLEPFSRRPRSMSHHLSSKDIPSRKALTLRARFWRFLMTLGMHFHDWAPPRAPRPSFKHEIPTDTIPIELYFYLPPRYHGMLDHEPDFRFPAVINFHGGGFCLGDARDDRYWARVVMEYTNAIFISVNYRRAPEHPFPIPVDDCVEAILYVAEHAVELHIDQSNIALSGFSAGANLAFSAPFRLSYHRNLIATTHDADSRPTTAQTVSTMGSMVHDDSDTEANDHDHDHDLHDHETYNFVTPVQSTSNLVQHRTRTPLQIRSIVAWYPLLDWTMSRSRKIRESRNPKKCLPKTFTDLFDFSYLPPPDVVGDHCSPYASPGLAHDHMIHECLPQDIQMWLCEWDMLLREGQVFADRLERLGKNIDSKLIPRVPHGWDKSPNPFRDQKAVDFLYTKSAINLNKVFQNKDGLGPGNSMSSLHPTDSIIERQPRRSIVLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5Z5</accession>
    <name>A0A0D2A5Z5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocation protein sec66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240423.1">
        <property type="nucleotide sequence ID" value="XM_016375147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5Z5"/>
    <dbReference type="STRING" id="91928.A0A0D2A5Z5"/>
    <dbReference type="GeneID" id="27327865"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00782"/>
    <dbReference type="HOGENOM" id="CLU_066294_0_0_1"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27145" checksum="5A657FF27EC2925A" modified="2015-04-29" version="1">MQFLSLLIPIAYLGILIGSLATFSHLYRQRQIKSKLRLAPYFPPHSARNVYLSLLHLQDSSDVKVPESVLRAALLARAVEDWQRIQEIRTRKPALAQLLQRGVVGDEIFQRLQRAETEIELEAKDVMNEANALAPNWGNYIFQTANEMVLNKILRDKLDSVKATLPAEQEAWAAQRERSRRELEGEEAQGQPQPTEISSSEKEKPLKAGSSDDDGVMVETPATEVTAGTGVSTGKSKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A810</accession>
    <name>A0A0D2A810_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_01496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241133.1">
        <property type="nucleotide sequence ID" value="XM_016375857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A810"/>
    <dbReference type="STRING" id="91928.A0A0D2A810"/>
    <dbReference type="GeneID" id="27328579"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01496"/>
    <dbReference type="HOGENOM" id="CLU_2061511_0_0_1"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW20917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13577" checksum="665B63A8FB13BE69" modified="2015-04-29" version="1">MAVALVQGKERIYLKHFYDRIAQNQAAFTPDVVDFYVMQFSQPDALRCAFLTYRAFEIGAEHNRRGREESRKVKIKNMVLSGKDSFLAPHAASMAKEFYEDVKVGLVSDSGHYLAEENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT54</accession>
    <name>A0A0D2AT54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_12043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847504">
        <property type="protein sequence ID" value="KIW09700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229916.1">
        <property type="nucleotide sequence ID" value="XM_016386350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT54"/>
    <dbReference type="GeneID" id="27339126"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12043"/>
    <dbReference type="HOGENOM" id="CLU_2003945_0_0_1"/>
    <dbReference type="OrthoDB" id="10299747at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW09700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="124" mass="14507" checksum="0D3667156562CF7C" modified="2015-04-29" version="1">MLTDIQGPEAYVRCVEQNLQTLSAAVDGCRNAVHLMHEELLSSTERNHQCHYMNMSLLQQRDELAKEVNHLRNNTSEDTSAELEIRQLNKMIDILQKRIFEPERIRDDQYKVRNVLKATQVTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AV62</accession>
    <name>A0A0D2AV62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rhoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_11562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230814.1">
        <property type="nucleotide sequence ID" value="XM_016385870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AV62"/>
    <dbReference type="STRING" id="91928.A0A0D2AV62"/>
    <dbReference type="GeneID" id="27338645"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11562"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW10598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="193" mass="21571" checksum="B1191158C8382F27" modified="2015-04-29" version="1">MAEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAIDSPDSLDNVQEKWISEVLHFCQGLPIILVGCKCDLRHDPKTIEELAKTSQKPVTPEQGEEVRKKIGAYKYLECSAKTNQGVREVFESATRAALLTRGRGKSKKCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AV98</accession>
    <name>A0A0D2AV98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_11352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230606.1">
        <property type="nucleotide sequence ID" value="XM_016385662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AV98"/>
    <dbReference type="GeneID" id="27338435"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11352"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="30"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW10390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="529" mass="58969" checksum="57958D8B703444DE" modified="2015-04-29" version="1">MGKDYFEVAGRKFPAVTWYRDPALRRTYIILMFVVLTSATNGYDGSMMNGLQTLQPWKDHFGNPSKGRLGILNAIMAAGSISAIPFVPYAADILGRRMGILVGCIIMLVGVVLQSIGSNYDMFLGARFLIGFGVAIAHGASPLLITELVHPQHRAIFTTIYNTTWYAGSIVAAWLTYGTDHINNNWAWRVPTIVQAAPSLIQVCFIWFVPESPRWYIAHGKEEKGLAILGNVHANGNIHDEMVQVEFVEIRDTIRLEKELESNGWIELIKTKGNRRRLIILLSAGLFSQWSGNGLVSYYITKVLDQIGYTDTLTQNLINGVLQIFNLFIAVLSCFYVDKIGRRKLFIFSTTGMLITFICWTICSARFAITGAKAAANAVVGFIYIYYFFYNWAWSGMLVGYTVEILPYNLRAKGMTVMFLMVDAALFFNQYVNPIALGNIGWKYYIVYCVWLAVELAVVYFFYVETRNTPLEEIAKHFDGDDAILAGGAATHKGLALATEMGLEATVMHATDEKRGGAEVEHVASRGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVQ6</accession>
    <name>A0A0D2AVQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">L-ascorbate oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231039.1">
        <property type="nucleotide sequence ID" value="XM_016384437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVQ6"/>
    <dbReference type="STRING" id="91928.A0A0D2AVQ6"/>
    <dbReference type="GeneID" id="27337205"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10122"/>
    <dbReference type="HOGENOM" id="CLU_006504_3_0_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249206" description="L-ascorbate oxidase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="258"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="385"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="656"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW10823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="90840" checksum="87C4FA99A14A2934" modified="2015-04-29" version="1">MRILGVSGFLALGLSANALAENWNDWTSPCTTSTAMTTSSSRTVDPISQSATKTFHVEKVSPATATVTKTETTTVWKATTTVYHSTIFIGPGFCATTTVTVDGSGRPFPPLNPASTQAASQTGSYAVDPVAGSPATSTFVVDPVNTDAGSQGPVTRTYTSIVETTIGTDGEVFTWTGEPPSSIATQAAPTYTNFPNGSWPEPGSPASNVSAPNGPITGGSQCNTAADRSVWCNGLSINDDTSVKDVSTGNTCSYDFTITNTTIDFDGSGPKLAFAINGQVPGPLIECNWGDLLVVTVHNQLTANSTSIHWHGLWQRGTNDQDGVPGITECGLAPGTSRTYTMQLNQYGTGWYHAHTMTQYADGIRGPMVIHGPATSNYDIDMGTVMIDDTFADTAAQQNERNSHIGPSGTQNYLLNGKNTMPDLSAGQHALWKVQSGKKHLFRLINSAAQNVWSVHFDDHTMTVIAIDYVPIVPYETEWLNIGIGQRYDVIVEMNQPKAGYFLRAVTQTGCPSSSVNTGLGAANGILLYDDVDPILPTSTYGDKTLADFASCLDEPIASLVPFVKKSAGSSSAFAASVSTLPAGNVARIAASDGGSVFRWYINSNAIHVNYSQPTLETLYENGYGVGGNGSSSNTNATTATTNGTSSSVSPSDLISNSITLTAKNTWVYFVIQNQFFAAHPMHLHGHDFSILGQGSTAWTADLASTLNFDNPPRRDTAMLIGSEGPTKASGYTVIGFETDNPGAWLMHCHIVWHVDGGLALQWIERPDDIKPYAASDEFQSECDSLTDWQRSNPLGIPSSWQSGLRKRVYLDDAAGGVVRRRSESSPRDFLASSFRRRIGDGFKLRHGHGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWJ0</accession>
    <name>A0A0D2AWJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231274.1">
        <property type="nucleotide sequence ID" value="XM_016384672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AWJ0"/>
    <dbReference type="GeneID" id="27337440"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10357"/>
    <dbReference type="HOGENOM" id="CLU_007091_3_0_1"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW11058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="738" mass="81654" checksum="6F0770A27B10EE8F" modified="2015-04-29" version="1">MVSSSVNGGDDVQPNPRKRRRPPISCQECRRRKVKCNRAEPCGHCVLSKKQCHYGLGSAQDRRIVHDRAPSGRIVNDRTFVPYATPTQATASAIGPSPASDATRLSGHVLAAQPPVEHSCGIARCAYSGETTNVTPDNVTNVPPGARMSLNKSRLFGKSHWTNSTLDFQRTAAVLDTESGNAPENESLARLKWEIGSLLQKCKLRSNKIKSCQLSRCRFYAQANLSVAKDIADEMVHLYTTRFESVFRILHVPSFWNEYELYWSEPLVARTVLKLKIQLVTAIGIAIRQAPIDVPDVYTMARQWLYAAQEWLSGPMKKNRISIESLQLQCLLILARQALAIGGDIVWISMGTVVRTAMQMGLHRDPKHFKKMGILEGEIRRRLWATILELNIQAALDAGVPPTISSNDFDTEAPSDINDKDIDEETLALQEHAATAPTDSSLQRFLLQSLGARLEVARRMNDITSAMPEMSYDELVTLTTSITNACRNCSTHILRTISPDIAAFHSNFADLLLRRFILHLHRPLAGRARSDALYYFSRKMSLDAALAILDPLPKNAEFMHLVLLGSGMFKNRMIHASLAVALELLLDVQEQVLVVSSQEPSGYRKMLMEALREGLRQSAERIRLGETNVKLHMKLAMAMRQVEVTGGENSSSSTTQLAQSAKESLESSYATIVRRAADEGDVDVEDRGNGGGSLEDFEPDGFDPEVFSIGSGFNLDDLFLIPADLDMTIDGTAAPTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWM5</accession>
    <name>A0A0D2AWM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231309.1">
        <property type="nucleotide sequence ID" value="XM_016384707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AWM5"/>
    <dbReference type="STRING" id="91928.A0A0D2AWM5"/>
    <dbReference type="GeneID" id="27337475"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10392"/>
    <dbReference type="HOGENOM" id="CLU_290027_0_0_1"/>
    <dbReference type="OrthoDB" id="5407305at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="933"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1056" mass="113684" checksum="4DCB9567EBF42531" modified="2015-04-29" version="1">MPIRDVAERPPSPVFSQPQSVSARSSEQKGRKKDWVGSASKRLRLPKLREKRSLSQVQEASMPSKESAQKPIVGPAKSRVATPVAAQLTQKSTLERPGPTKQSSSPTDKPLPSLPVATVDYKSPVRRSLIDCSERPLRRSVSPPDGGPPKEEEWPSIQPSTGTTVPIPEPCKAPAKPSLGESIIDGLRSLNLQDNEDEKEKGYPAVEFANSAVERKKESKSHSSGRQMHTSLGILDNDSDRPLSSSQLPKPRDSMLQTLSRHTDNPVIRQTKTSAMRLQNAMGKRTWSSGEKSVATEDALPSIQQPSTLLGKPRHIDGRGPNPTRSASKGRHAVTVRGSPYIIPTRVPLRANAASPANQQEMTHDDHSMMVSGGLENSISHGLDHVGRKEESTAKDVSRQSSLPVPSRIKGERASPGTEGVSPHGQPSLDDTSKPTECPGTQGSSGAASTNSSSPRVAGQSPPVADSCIDLRDALSSPVPPLDHTVRSADISNSTTRGYDSYGGFRIKHLGNGLLEGPTLRINDSASRILLGSDEKASDPVAPSARSSVILRRKRSAPEIGQRKDTKTSSRPTSAIFDRPLSFIARNIADRTSEIRALGDDEVRQLIGDCDSPSQPQSAELPGRESVYVHDSRPSSLIIKYVKRDSWESPRNPAPVQCDWPGKDFAEFNLCASPDRSPPKLTSASFYEKGDPSKSKSSIYTDAEPPKTGSASIKSITSRPSTIALRAPPSREIAPFLFQDTKNGEKKGKESIGKVSVRLEVSGGADSGDSTTTYPPRVSSRRPKPPPIIVSPPQNAGPTVSIKPRASNGREVDPDFLKKPRNVKTFSQSVSPHTDSTKARRVARKLGYTPTSSSKKVISNLRGLFHKRSVESETTNDDGTGSIRQSLMPNPLRINPSDCGAAASDNTNSAPRNLIRNPFISPTTPFTATVQPSPYPGISGVSAQQRDNAKASGSADTTPPLPSPAETLANATTLTHSLLDLAHIETDLQRKSHLIQMSKCMVEVVGAARDAEKAMEKAKMEAARAEVSWLKVQKTMAEMVEHVVKVDALSRKQGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AY21</accession>
    <name>A0A0D2AY21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231814.1">
        <property type="nucleotide sequence ID" value="XM_016385212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AY21"/>
    <dbReference type="STRING" id="91928.A0A0D2AY21"/>
    <dbReference type="GeneID" id="27337982"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10899"/>
    <dbReference type="HOGENOM" id="CLU_064759_0_0_1"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="292" mass="30949" checksum="8EA3CC71B834BAF6" modified="2015-04-29" version="1">MSFFKKLKDELKEMLNDDDDKDKQKQQGGHGGPPESAAPPGQYQQQRDFSQAPNQYPPNQPGPPGQYSYNAPPPPNAGYPPPQNPPLPPGWISQFDHSSQRWYYVYQPTGQTQWELPGPAPGVPPSAPAPGFQQSYGQAMPSVPYMQGHNEHSREYYAGSAQPAKKGSGMGGMVAAGLGGAAVGALVGHALGDSDSDNEGHAAATGYGAAAPAGYGAPPGPPPPAAEPPLEFNPELSSSQRSSLQEAREDLEEARAEVAEDSSPSSSDIEDLREAEEEYASEVESAHEELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AY22</accession>
    <name>A0A0D2AY22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231551.1">
        <property type="nucleotide sequence ID" value="XM_016384949.1"/>
    </dbReference>
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    <dbReference type="STRING" id="91928.A0A0D2AY22"/>
    <dbReference type="GeneID" id="27337718"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10635"/>
    <dbReference type="HOGENOM" id="CLU_010733_0_0_1"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1066" mass="120941" checksum="DFAF0AF51D45FE14" modified="2015-04-29" version="1">MTSAQYALVPVTQTFGRRLLSTTCSALRQPPAANLSRRRVIHRRGICHSPATAFSPLSIPQHPSRGESREASSRGPKQGFTAPTSSISLSDEPFHEWPGIQELRAQPDSEYGLRSDEGEAYAATEVDLDAENGEKDKQNFLRKRLDSFISIFMPSRARQKIDLSYKNPIEWEQNLRKLESPATLEFRSSTPLRRLLLEYLLHVEPYIGGSLSQSSPNVDSRLDHALETVFTEENITILNTIGYSVTDVVSWAWIFTSRSIEVAVQKYVTLATTQRVAKSGQIPKFILLQILRAPQVNAFALKQLIESIVAELHLCKAAKRYPGWGWTTRVCLVVRLLRHARQVAPESFKDISMIVEHLFSDFYKINGRSVEAAELKRLSHVFNRFLTLISVSSSRTFSSYLVKQNAQLSLVRLMVGFKPQIPLTREGYRALITVQLQHPKTEQERAWAETKSLSWPPWRRINSGIEQDLQYPGKESRAMKLLRRMNQAGYSHGAWEKSAAILAGWDTDKSPTIQTRANLRLPRQAWKIKKQNIDALDSSSHEAAEIWAARVQATRTKREAWACFLSYERNTELSKRRYQPYFAMCHKLLASTATFDSVLGSRHLAGDIKEVFEEPVSPRDVTYVDREVPSLSEFYNDMLQVGIVPGGRLLGDLLDQAPDIEAGFAYIQDSRWDEVTKDVLRHAENYTPMIIRDTLGRVPHLCLAAFVHLLSRHGFDSAPDFAVMSEKYNEHTGQWMEAKRFVNPLTYAIVLLRVGECKNTLVWNAFVRGAWASVRNNNVKVRDGFLTHLDKRHMDHQIWDFLRNQFNPEQTDLEIHPDLESFRLMAGILIFMIKEANHGRMRVDSTEIGSLAKATFLRAVYGRNFPRFLPSRSESVLRLPEPSDLQLVVRLLVSVSDTEGLVAVVEWINSHAESYGSKVNAGDEIITRDKTTVSLRCVLCIVRLFLEGCPATADAEQLHHFGTPLTVPAYVIQKAKNACGRLKWPSDQEIEMFLSRESEWMKRVAKAVKRPRNERLTNADVPQQSRHQAEDQTWDARQEGGGVRAGGAGGDLDHTNTSVPIRKHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZF3</accession>
    <name>A0A0D2AZF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232269.1">
        <property type="nucleotide sequence ID" value="XM_016383646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZF3"/>
    <dbReference type="STRING" id="91928.A0A0D2AZF3"/>
    <dbReference type="GeneID" id="27336410"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09327"/>
    <dbReference type="HOGENOM" id="CLU_013987_1_1_1"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="150"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="633" mass="72054" checksum="97599BFFDA4A4342" modified="2015-04-29" version="1">MRCSKEIPCSNCMKRGIASECHREPVLLTKQKRLNNPASNERQFYHDRPTSPVTANHLNTAERVSTPTSTDSPDAVTHSSPRDHRRDPGSETFGVLESLAWGRYSNTPQSTNSRRPARYGTSEDCPNLLPLQQEDAILAFHKNEIAWMHNVIHMPTFMAEWAERRQQPRDRWTAMDALYFALMATGLYYMSSDQHGQIGIRAGFKLSEKLYRKAVMILDLVDFMAEHSVYSLQAICTFLPCAYGFGDYKRALVLLSAATNIAQCMQLHRIDSANKSSVISATDETLQQEIKRRIWCFLVIQDTYLIAAKKTYNIILEHCTTSLPAHIEEPTSTSTSERLEVIPLEIVTQNSYILLHYHLSRVFRTLHSRTGPAPTERPSLDRLYQRVLEADEQLTEFMELAPSWVKQDQSNGDDPDANLPSLSSRMANSQRKTFQIAFLHMRSKIHQPFYCRAFTDKRFYYSKATCLDSARTLLKIFAEADQALPAMWTMTSHVVCACLTIGIHLLFPQHSTRISGSWERSTMEAADRALVNSCMTILAQSERPCSVAKRGVKMLAHLFSQQQQQIPPNMIIDRERVESILQENETSSSEEEEEEDQERLSISAFGHELDEVVGGFELFTNSHGYCLEDFAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0A2</accession>
    <name>A0A0D2B0A2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232604.1">
        <property type="nucleotide sequence ID" value="XM_016383981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0A2"/>
    <dbReference type="STRING" id="91928.A0A0D2B0A2"/>
    <dbReference type="GeneID" id="27336748"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09665"/>
    <dbReference type="HOGENOM" id="CLU_017748_1_0_1"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="244"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="491" mass="54965" checksum="AA77E9F62D362F6F" modified="2015-04-29" version="1">MGSFPPTPTSTQRDVARPNVQTYDNTEDWHAFPSPPPSPLFDRELPVVPTNGSGMITSDSSIGNDKSAPAPETAKKNIRSQRRKVTYVSRHFTTDGSSVDSSRTERQLNHALKKVSTAIDDIRKIVRVETCTLASSPGSLASHTGSRIYYGVNIDELSSDSDLTDVPDDIGPDPFISTTNENSTSEVLSKPTKPPRRPTKSPYFPHPHKHRPTFLSTLPFPPLSHATFGLMQERLAHDPFRLLIATIFLNKTPGERAMPVFYELMSRYPTPLALSNAEVSDITSLIYVLGFQNQRARKCVAMARAWVDRPPERGKRYRKLHYPARGDGKDVGVDEAIGDEDARVAWEISHLPGLGPYSHDSWRMFCRDQLRGLSTGWNGEGSVNKDHAHADSQEEPHSFEPEWKRVVPLDKELRAWLTWMWMKEGWVWNKETGQRQRASDDLMAIANGGGIVVEEKDSDHLIVKSVGEEHVTDLQGLKKVERTVGDFLPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1M5</accession>
    <name>A0A0D2B1M5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-histone chromosomal protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_09792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232731.1">
        <property type="nucleotide sequence ID" value="XM_016384108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1M5"/>
    <dbReference type="STRING" id="91928.A0A0D2B1M5"/>
    <dbReference type="GeneID" id="27336875"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09792"/>
    <dbReference type="HOGENOM" id="CLU_082854_10_1_1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="102" mass="11483" checksum="16EBF35737CCED29" modified="2015-04-29" version="1">MPKAAAKSKTKATRGDKKKKDPNAPKRGLSAYMFFANEQRENVREENPGISFGQVGKVLGDKWKALSEKQREPYEKKAAADKKRYEDEKAKYNAGGSDEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1T3</accession>
    <name>A0A0D2B1T3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232781.1">
        <property type="nucleotide sequence ID" value="XM_016384158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1T3"/>
    <dbReference type="STRING" id="91928.A0A0D2B1T3"/>
    <dbReference type="GeneID" id="27336925"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09842"/>
    <dbReference type="HOGENOM" id="CLU_150777_0_0_1"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="110" mass="12538" checksum="C8793B33EFC5BBD1" modified="2015-04-29" version="1">MASASRGRLLELAKLQCSIFSTTFNPNQQRLGNKILRARLRGPALASYYPRRSTTVEDMLNEFKRFDLEGSNEDEDARLENIQLAKLRGKGAPKKKRTAEESRLKKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B270</accession>
    <name>A0A0D2B270_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232921.1">
        <property type="nucleotide sequence ID" value="XM_016384298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B270"/>
    <dbReference type="STRING" id="91928.A0A0D2B270"/>
    <dbReference type="GeneID" id="27337066"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09983"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="344" mass="38194" checksum="5C9EA24A72B1E256" modified="2015-04-29" version="1">MPALSHRGGTVLVTGATGFVGVWIVKKLLESGYQVKCAVRNDSKAQHLKNLFASHLEQLQLTPVGDISDEGVFDEAVKNVSAIIHTASPVHMRANDPEDIINPAVRGTLGILESALRYGSQLERIVLTSSCAAICSQSETNITLSELDWNDPSVQECREKGREALPLSKYSASKVLAEKAAWQFYERHKPEIAWDLTVLNPPWIFGPTLHEVPDFTAINPSWKLWFRAVTQGAEAQLTRPGHGWVDVRDVAEAHVRSLEVATAGGERIIICASQFVWQDWIVVAASMKNLRDHYKIANPVQGTISRAILFDSSKQKEILAIDFHKMEDVVRDSLENFHARGWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2Y0</accession>
    <name>A0A0D2B2Y0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233181.1">
        <property type="nucleotide sequence ID" value="XM_016382478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2Y0"/>
    <dbReference type="STRING" id="91928.A0A0D2B2Y0"/>
    <dbReference type="GeneID" id="27335235"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08152"/>
    <dbReference type="HOGENOM" id="CLU_021043_1_0_1"/>
    <dbReference type="OrthoDB" id="2688021at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="570" mass="63502" checksum="1470FEA736F5BFB8" modified="2015-04-29" version="1">MPFAAFRWLDRRKQSLSSETTEEGCRVLAERGVPRSNEHSESEEDSEGRLASSKGDALPLEVIEPGTWTLRVCILGLATMWLTGLATIIYGSIVEASSKGTFQHWGPSFIHKRAIGPLTQLAIAFWITLLTDIAGLVHSTSLRFSLLARRKLTFNSNLRLFTSCPDSPVHSWPINIIWAWSLISSYACGSMVIVESVYDYSNSGEVGFHTYDIVSGYALIFLGFGLLGQALIASWALMVCKFPSWSTNPIKTAKICRDLGWLRPLTQRTMLSVHDAQSLEPHDSPSLPKVRQGSLLRAHSNVRPALIFVWVVTALSFLWFIAVTLAYQLGGSSIGPSWGTFSRSYTNDWSLIPDWHDVTAFIAISTSLGQSSYTFGPWFLCKYLLTCVFLGGITMDLHVVELLVQCSRDESLWRQTASARGLDRNRDGALEIAFRSWETIALFVFKTAVNWVFSMAFGPYWEGIEMRIPQICYTAISLFWLSLLATYLALWKPKGPQPATFGHLPTLVDLIDVWPGRGSNERSENAVDGGAKADHLPLFWGDKGTRDNGFRRAGTDHAPLQPIVMTALYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3E2</accession>
    <name>A0A0D2B3E2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial GTPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_08342</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Mitochondrial GTPase involved in assembly of the large ribosomal subunit. Plays a role in expression of the mitochondrial translational machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233371.1">
        <property type="nucleotide sequence ID" value="XM_016382668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3E2"/>
    <dbReference type="STRING" id="91928.A0A0D2B3E2"/>
    <dbReference type="GeneID" id="27335425"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08342"/>
    <dbReference type="HOGENOM" id="CLU_011106_0_1_1"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="5">
        <location>
            <begin position="134"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="141"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW13155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="338" mass="37327" checksum="86B5B02565D7FF85" modified="2015-04-29" version="1">MEAFVPRQVYPHLSSIPRSYYLGHHAAGLSKMKSLVSQIDLVIECRDYRTPIVSRNPLFEANLGERPRLIVYTKQDLGSNSTSADRKRENIIRKWDAPSTSLFTDIKSRSTISKVLDFARAHANHSTSLFGTRLMVVGMPNVGKSSLLNALRNVSLGKKKAARTGDQPGVTRKIGTSVKIIEGDEGREGVYVLDTPGVFVPYVPDAESMLKLALCGSVKDTIIPPTTIADYLLFHLNLNDPTLYGMFAAPTNDIFVVLEALARKQGRLKKGGLPDFESSALQFVQRWRSGQMGRFILDTVTEDALTKRLDMLTSYGGSLHQARKAAKQLRKEAYLGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5Z5</accession>
    <name>A0A0D2B5Z5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_07115</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234549.1">
        <property type="nucleotide sequence ID" value="XM_016381447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5Z5"/>
    <dbReference type="STRING" id="91928.A0A0D2B5Z5"/>
    <dbReference type="GeneID" id="27334198"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07115"/>
    <dbReference type="HOGENOM" id="CLU_154847_2_0_1"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW14333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="94" mass="10640" checksum="36727B68EF9C34A2" modified="2015-04-29" version="1">MTVIESVKDAIGLGGDAAPASREAMSEARLPLQYRDSCANLLIPLNKCRHENAWMPWKCEHERHSYEKCQYEEFKKRVAKMEALRAAKSAEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B640</accession>
    <name>A0A0D2B640_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF3429 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234376.1">
        <property type="nucleotide sequence ID" value="XM_016381274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B640"/>
    <dbReference type="STRING" id="91928.A0A0D2B640"/>
    <dbReference type="GeneID" id="27334024"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06941"/>
    <dbReference type="HOGENOM" id="CLU_045137_0_0_1"/>
    <dbReference type="OrthoDB" id="194289at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="37881" checksum="9BC18787D9A1F4A9" modified="2015-04-29" version="1">MSATMFRTTAVRSIPRSFQAPAPRANVYNNILRASLRTSARPAKSARVLSLTVARPFHTSLVKYEMKGADKAAAWGSSAKQFEENLGKEVLKPTPQAVSASSSTRAVASETTADHDDDVDMMEGIRADFKTIKETFSLEEVPRQALYVGMAGVLPYLATSLSTVYLSFDIQYAATHGQGFLLSGETAETLLHIIEPIQLGYGASIISFLGAIHWGLEWAGFGGYKGYPRYSMGIVATAVAWPTLLLPAEVGLIAQFLAFTFLYYNDARAAHNGWAPKWYGTYRFVLTFVVGASIVASLIGRGQIADLVTRPPGPADRMRELRQKQLAELGPEPEGDEEEEGEDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B666</accession>
    <name>A0A0D2B666_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_07165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234599.1">
        <property type="nucleotide sequence ID" value="XM_016381497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B666"/>
    <dbReference type="STRING" id="91928.A0A0D2B666"/>
    <dbReference type="GeneID" id="27334248"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07165"/>
    <dbReference type="HOGENOM" id="CLU_055491_3_0_1"/>
    <dbReference type="OrthoDB" id="4112487at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW14383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="143" mass="15462" checksum="1751DCD9C30E08D2" modified="2015-04-29" version="1">MSQKPSSPPTTVTGSCLCQAVKYTVSGSPRGTVLCHCSNCQKTTGSAFANNLRVLKSKLTILSGEDKIKCHKDSNTKSGIELSRYFCGDCGSPVYLTNPEFQGLVVLYTGCIDTDAKHERPRGEMFGENTRKWFAGVEGASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6G8</accession>
    <name>A0A0D2B6G8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">beta-glucosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_07072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 10"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234506.1">
        <property type="nucleotide sequence ID" value="XM_016381404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6G8"/>
    <dbReference type="STRING" id="91928.A0A0D2B6G8"/>
    <dbReference type="GeneID" id="27334155"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07072"/>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="426"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW14290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="868" mass="95073" checksum="F9D9C66BFA2FCCFD" modified="2015-04-29" version="1">MAADQTKSSDDIDYLLSQLTDAEKVSLLSGADDWHTVGIERLGIGALKVTDGPAGARGQLMVDGPQSAFLPAPVLQAATWCRSDLKAVGRLLCREMKTKSAQILAAPTICCARNPLGGRNFEAFSEDPFLSGALAIEYVAGLQQTGEVVATAKHLVANEQETERFTVDSVIDEQTLREIYLRPFESLIKSSSPPGCVMTAYNLVNGQHMDEHAYILRDILRTEWKFDGLVMSDWGGTNSTVASVLAGCDLEMPGPPVQRGHKLLAALESNPSTEFQNAVGGSCRRLLTLAKKMNLLGLTASQVKDSRNRPERSATSKADLQSLREIVANGHVLLKNSAGTLPLSPSRLPGKKVAFVGPNAKSCTAGGGGSASMNPQYQSQPLQAFQEQVSQLKLDVEIHHAQGAYSSKWLPLASSHQWSANPTPDHASDMLRVDFYAGLDFSGPIIETQYRNNSSIDLTDSSPACLRESGKPYCFRVTTYVTPDTSGCHQFSLASVGNSRLIVDGQLLVDNYEWTEPGEAFYAFSSAEKCASVVMTQGKIYPIILEAATKESDTLMEDDAENTAHVWSKQASVRLGYLEELSDNMVSEAVELANACDYTVVVVGLSDEWESEGYDRRSLSLPGNQNELIETMLEHTVHPENVIVVNQSGSPVEMPWATRAHTILQSWYGGQEAGYALADVLLGLISPSGRLPVTWPKRYSDLPFEKSKESWPGVEGRVHYKERTGVGYRWYLRNGVEPQWWFGHGLSYTSFSTRVSQSRECADQSWEILAEVENTGSAGGRHVVQIYSWPCGDEHQKELRSFEKTEVLAPHARSEVRLQVKLRDMAYWREGRWTVAAGDYVLGIGESAGAVDIVAATLSVPITLTWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6N7</accession>
    <name>A0A0D2B6N7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234734.1">
        <property type="nucleotide sequence ID" value="XM_016381632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6N7"/>
    <dbReference type="GeneID" id="27334385"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07302"/>
    <dbReference type="HOGENOM" id="CLU_169116_0_0_1"/>
    <dbReference type="OrthoDB" id="10042947at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="116" mass="12176" checksum="035C627EA0AA16B7" modified="2015-04-29" version="1">MAINAAGIVMGAQGLFLLGNGVYLLAFPDRPASDPNGPFYNTPVSVIRAFSTTSFSIGAFYLQAVYQRNRSVTALSVVGRAMAVGVFGFMCGEGAWRKVAAFEGAMGVLLALSLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6T2</accession>
    <name>A0A0D2B6T2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234819.1">
        <property type="nucleotide sequence ID" value="XM_016381717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6T2"/>
    <dbReference type="GeneID" id="27334470"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07387"/>
    <dbReference type="HOGENOM" id="CLU_084522_0_0_1"/>
    <dbReference type="OrthoDB" id="2446447at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="65"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="217" mass="23504" checksum="39B61CE523BF6DDB" modified="2015-04-29" version="1">MVEVKRYNLPPTALIPNSPQPLLHYPGFLSVESGNDAATKIYDLFSSNGWKTQWIFRYGQTQTSHYHSMAHECMVVLTGTATIRFGVADTDSDLEKSTYGDGREEGGVEVSAGPGDVFILPAGTAHKTFNASPLTEFKLLTPGDGHSVAAEDVREALANIDLSGFTMIGAYPQDGGEWDFAKGGENAGNYEQVWSVPKPDKDPVLGDSEEGICGQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B836</accession>
    <name>A0A0D2B836_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235244.1">
        <property type="nucleotide sequence ID" value="XM_016382142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B836"/>
    <dbReference type="STRING" id="91928.A0A0D2B836"/>
    <dbReference type="GeneID" id="27334898"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07815"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF6">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="19"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW15028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="365" mass="39336" checksum="C1DAEAE03DED7096" modified="2015-04-29" version="1">MSQVDIPIKQTAALVLKQGGPVVFDDDYPVPRPGTDEVLVKVLYTGVCQSDLHTKAGTATGADGQPITNIKLPHVGGHEGVGRVVGFGPNVSPRDDLQLGTLVGIRFASRVCHQCEYCTSGREQHCTNATNHLHHEDGSFQQYCVLDTKYLTLLPQDVDPKVVGPTLCAGVTAYKARRHQAVVNARLKEGEWLTVIGAGGGLGHFAVQYGLCLGAKVLGVDAGDDKRRFVEDLGARFLDFSKCKDLAQEVLKITGGGTHATVVTSGHPRAFRRLADMTRVGGSLCMVGIPPGEVHLDIPIATIVIKGLRIQGNLVGSLKETLEAVELVRDGKVKPRVQIRPFRELPEVYHMLEKGDIPGRIVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8D6</accession>
    <name>A0A0D2B8D6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235404.1">
        <property type="nucleotide sequence ID" value="XM_016379577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8D6"/>
    <dbReference type="STRING" id="91928.A0A0D2B8D6"/>
    <dbReference type="GeneID" id="27332316"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05233"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="237" mass="25075" checksum="489343E7DBF844C5" modified="2015-04-29" version="1">MAGLSSLPNVTCLELDVTSQSSIDNAVATVRETAGGRLDGLVNNAGAAIMGPAIDTDMLQARRLFDVNYWGMVAMTKAFAEMLIAAQGAVVNIGSISGVLNAPFTSMYAASKSATLTYSETLRLEFAPFKVKVLTVVAGVVKSHIGDNTHVSIPQESLYRDAKEALDERVKNAGASVQVTAERFAEQLVRAVELGQSGQIWIGGSAGTVKMMRNLLPASILDRLVSQGTGLEKVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8T3</accession>
    <name>A0A0D2B8T3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_05384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235554.1">
        <property type="nucleotide sequence ID" value="XM_016379727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8T3"/>
    <dbReference type="GeneID" id="27332467"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05384"/>
    <dbReference type="HOGENOM" id="CLU_460786_0_0_1"/>
    <dbReference type="OrthoDB" id="4111629at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW15338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="599" mass="68522" checksum="1BBA87CDAAADC168" modified="2015-04-29" version="1">MLALKSMRVPSLTTEHATTFQELPSEIVDLIANELYDGGFGLADGLLAFSLVSRQFRRSALPFLFSSVTHVVRDRLDQQEHGALRRFLSHPHLLRHVKDLHIARPADIHGFVPSLDAVSARCLAEDHKSADVQVIQNSLPLMTRLHRIRMDCSAATALEILKLLPIDHLYEIILDHIYTSSHWPTLIEANTELATFARKHRLALGAYGLPPPQRTTNSQATYDAIARAAAVDLHMAWLLKDDRKAQGSAPAHNACIQETPSWTELRLLIRRACGTTTYSIRDLDLTLVPWTNLRRLSILWEYAMPMNQFIFDVAPKLGNLEALRLRADHQRLYHPACKYDVPTTGLYADTPTVPAFEIDYTQMKRLRELEIDGICNHVPIQALLGPKLRCLRLHREDTLWSVYSPESQRSPSDIIAATKICPDLERLELDIGYIENLWHPTAIPGVDVDVEQYSFLNAISRFRHLRHLRLFPPFVPKDSPRFSRSVPHCVPVSDDQAIRVFEHLRTECPSLQILSIAAIPSFVMIDTMCWVVRRRGEKTVLTTKHRERNYQHRQIWVGQRRISSEIKRFTAPPSYLPDPEGWMLTRDDSYEGGRRSLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B908</accession>
    <name>A0A0D2B908_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235609.1">
        <property type="nucleotide sequence ID" value="XM_016379782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B908"/>
    <dbReference type="STRING" id="91928.A0A0D2B908"/>
    <dbReference type="GeneID" id="27332522"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05439"/>
    <dbReference type="HOGENOM" id="CLU_005733_1_0_1"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF18">
        <property type="entry name" value="NICOTINATE CATABOLISM CLUSTER-SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="396"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW15393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="935" mass="104233" checksum="0C4C8F1EA8A59F1B" modified="2015-04-29" version="1">MQFTFQETRSSRPPADRHMARHRQKDEEAGGEGLGVIESRKKLWRDADGKIVSKRPAQGEACRASAKKQATDGSYPSHAGSTITTEGCNPQTMIHAEPLSPPKSMLSAESLDHFSHQLPELPADRDFIDHTAGPDMFDFLANSSWGSHTSTSLGITGEMPLDDMFNPDTASSFNMPFTTMNNYNWLFDLSDSTRISLPASQNYNTMPEVQGSTQGSQMEALQYQPTSQQAPDLFRNGNRAFSSSSAEEIFRQPALQQTSSSSPAAAIQGTEMFQFSSPQVQNSGATTTSSLGPVEPHISGNPTPELDFSPQTTTSPDSMQTQAAHPVNMASHIPNSLFNIHTLPPSPPRRSMPTMDDVSRNEILDILVAAKPKTPEGSEISRDHPLLSLSSMQNYLDLFFSRFNVAYPLLHQATFDPSQTEPLLLLAVLLLGATYSEKAIHRLAVCIHDVLRAQIFQHSAFSSTPELWMLQTILLVECFGKSRAGQKQHDMAHLFHGLLINLIRRSDCQSVRQPNFGEGSGDLESDWRRAIDVELRKRLAFLCFLWDTQHAVLFSQSLCMSSFELRTTLPCNQTTWEASSAEEWWKYARKEPQISYLSVLKAYMNPDLGIQIPQLNALSRLLVLHGLMSVQWDMKRRDQTSLGMDKLNGSSSSSDQPKWQDRLSQSYDAWKADFDTYCMNMTLSLGDNTTRKAEFTRFSTATVAIYHAAHITLNVEILDLQIYAGARHIIGRPVTRADYDRSRRIIKEWAKPGGSTPAAKAAWHAAHLLRDGIMNLDNWDVNNAFHYPWCLYLSTLTCWAFHFANTTDKSGQQNGGGGGGGESGRDRNQHQHHHNYASLTTTTPTPSKDSHLDNIADDGIVWHAKAEMNALVSSMASVMPEHLWRALGKYSTSGLTAVMAKHLSNIRWAVVHEGMKVLRGLVPERSINEYETFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9R4</accession>
    <name>A0A0D2B9R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_05773</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235939.1">
        <property type="nucleotide sequence ID" value="XM_016380112.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2B9R4"/>
    <dbReference type="GeneID" id="27332856"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05773"/>
    <dbReference type="HOGENOM" id="CLU_000772_0_0_1"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032372">
        <property type="entry name" value="Blm10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16547">
        <property type="entry name" value="BLM10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 N-terminal" evidence="14">
        <location>
            <begin position="508"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="13">
        <location>
            <begin position="868"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="15">
        <location>
            <begin position="1859"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="12">
        <location>
            <begin position="2374"/>
            <end position="2462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="499"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1414"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2345"/>
            <end position="2366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1725"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1428"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2356"/>
            <end position="2366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW15723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="2462" mass="276669" checksum="E1004AA6641702C8" modified="2015-04-29" version="1">MQTGSLLQYGCSHPITTLTGVFLAWKSILLLVVVTSPGLGYDTSTSLLSAGLKQNVTGLASDTPNNIPTLWLNFVRWDAIYFTQMAQHGHVFEQEWAFGIGISSAIGWTSRILERFMDIDYSTSSMVAGVCLSHIAHWLAVVQVWAIGSHLSGEGSKPSQQQSQWPIPFLAGLMHILSPAGVFLSTPNTESLFACLSFSGFLTFLWATAYFNQAKVLRGCVSMVAAGVAFGLATIVRSNGILAGIPFLIEAATIGLAALFQVPSLPRLLRLASVVVGGLLVATGMVIPQFLAYQEYCAGRSPGQQRREWCEWTVPSIFTFVQSHYWNVGPFRYWTLSNLPLFLLAAPTLWILTQSAIEALQKPETIRGGYPLLASTNGRQQRLVASLALPQPLLAVLAFTSYHVQIITRISSGYPLWYVWLAAKTRGENAKHASVIIRWMMVYALVQAGLYASFPSAPGPRRNASRSSACSTAHSPSTPSSPTPWPCTLVSWDIRRTKPGSSLGKHGSEISRATSPAGAANMENGSPEGEDLVKRNRPRTYPYFETLPYPIEDEATRQENLSKILDQLYIALQSSDFTPGAVHWTKELRSWMSLKFDPTKAQRVKLVKLYFELALAPGIEPGVSERFASMFMLLTKRKHYLRPLKDLTLDWRPLYRELKVFVLPSESGLMQTTSLKRNIKTLTKITSFAQLYFDPEDIPAMLEEMLPHFTMSSAEGAFVVIGLLNMLLPTAPPPPNRQDLVPQQFLPTFFHLWSLVNRSRTTDVAFLDLFSRMARDTLPCSHIDFSEFGIFTAEQSTLMTTAILRLLEIPVGQSTSPYSALVDLSAGMGILLDRDSRKHPVSHHIARWFVMSLSPACLEKKTSVLSLLENLIQAIETFFHPSNSGSWTRTLAQLVFYLADFFVMRWNRERNGEMEVPKERRLNEPLRKRFVLCLREVIFMGIYAKSGTAMSYSLSTLQALAFLEPDLVLPGALQRIYPSMQGLVEVHRTVSSLRSLQILARTMVRTKGYRCHITALLGLALPGIDANDLEKTLYTLSFFGIVCYNIPFEDLSKDRTDIQGNMLAMEWITGEMERMEQEGASVELNYADLDENMEEMILASSTAGFSEFVSSFLGRVFTLLENLPDAARIRSGSPEENIVNTLPAAFQPLLASLSPELFDLALNKIVDFVANHVIHQSRDAMAFICNCLCKVNPEKALAKFVPVLISAIRTEIDENGAGTTRNAAADVLPRDRGLVWNISMLSMCVVHVGSAVLKYKQELFDIAIYMQQKCKGTSTVHVSNYIHHLLLNLTVTFTADHALYEPERLQDGIKPHLWGLAEPPATIKPKWHVPCKEEIEFAVELFQNQVETSLKHLRGLIQGTSSIKRDGSGKEWSDEVSRNLVLLRLLLAGISALFDSNGVNEGLKTTAAGIDAENSLSETNGHALDMSDRDDESDDTSGGDSYLDSTDETSLKPSFQYPCGQVLKPGDDLYRALHSLRQDIGRVLHEVHEFLTREGEDDVSSFAPLYTAYRSWFVDVGLERSAHVLDRVTRLLHADEHPYKVSGVRKDYPRSILVRRANVYHTQRVRHNATPRPRSELDEQLLLDLAQSSVSLYTEVRRNAQSAGESALKVIFGARLFVIPPLLASFQQAVKINNFPRIKGGLFALLFGSLAKTVGRHWKYTPDVIRTFIEASTADKPSIQKLCSGGLYQIMEYGRPGHRMAIIDRAFVDPFAPEEDVEDKIQKKKKFILTKRANIERKKAELAEELIQLARLSHWKKATRVATIVMSLGLRFDHIASDSMIDLITRGTIDPHPGLRGLYSQGLVALFTMTDVRAVCNHDYANYIQALQEFPAKVKVDTHAEDPAWTDGYLKAFSQPEADVYIDHDYPGWLVWSKTMPGYKANVKDDIIYDDLEYRKRGIIGKLLDREWFVTFFKYLKQEPRDQSADKFRMASAAMLTYAFELVIRDGLAVATFEDIKEETLKVFEDGSDKHQHRATAEILAGLVTSVMDNSIERRTMVWEFAFPIIQRVFSDGLTPENSGYWTTFLHMIMQARDPRRAWPLVEWLTNFRLDMGSNAAFKESSKIHLLHQVIMDAGWHFQLDAPITEDFFAHIDHPYKGVREAMAHTLATITRTRYHESFKDVQDLINAQKAAGSIGVQPYVPTKEFDDRMLEIFERLEKWRHERAPGQQTPSPYTSGSKTVLLWLDSMLSSYECTQLLKYFPDLFTEQFLHMMDVKEDPELQSLAYHVFRHLPNIPHHMGEDAKLIASLIRIGRTSPSWHQRLRVMINMQIIFFRRLFLLSEASKQKLFDCVADMLEDSQHEVRAGAATTLSGMIRCSPLDLRERMIISLRDRFTQMLIDNPLPKKPKGQLAGLSSARTSGTNTPTPEAQRLVITRHAAVLGLGALIQAFPYSSPPPPWMPDVLVTLSQKAANDPATVGNSVKSIISDFKKTRQDTWHIDVKAFKPEQIDDLSGVLWKSYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBK4</accession>
    <name>A0A0D2BBK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236609.1">
        <property type="nucleotide sequence ID" value="XM_016380782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBK4"/>
    <dbReference type="STRING" id="91928.A0A0D2BBK4"/>
    <dbReference type="GeneID" id="27333528"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06445"/>
    <dbReference type="HOGENOM" id="CLU_047598_3_0_1"/>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="295" mass="33388" checksum="2A81A825AF9A6F00" modified="2015-04-29" version="1">MSFNVRSSSILLNTLRCGPQPQKVYFPSVLSFKSPISSVSTALHRCQSVSFVFAPSHNGHVSKRRRLSSSCRATASLDIGHIEEPGSGRGSIFGGENSEESGSGMSSATETRGEVVRLQGELGRMSLQDKSESQHQVSPNAGDQNSGGKRRIGLRDSAEPRKQKSEPWKTQKDALKKKFGEAGWNPRKKLSPDTMEGIRALHEQDPERYSTPLLAEHFKVSPEAIRRILKSKWRPSEKEMEKKRERWAKRHDRIWDQQAELGLRPQRRKERAQEDPDEFEEKLRAKEMLDNARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BC06</accession>
    <name>A0A0D2BC06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236371.1">
        <property type="nucleotide sequence ID" value="XM_016380544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BC06"/>
    <dbReference type="STRING" id="91928.A0A0D2BC06"/>
    <dbReference type="GeneID" id="27333289"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06206"/>
    <dbReference type="HOGENOM" id="CLU_032013_1_0_1"/>
    <dbReference type="OrthoDB" id="3335528at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.20">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="42193" checksum="5FBF9E1C815B65E3" modified="2015-04-29" version="1">MDDLQMTAHHGCLEICFHLSFIILLYLLVSNASSLPPHTNHPLRYEKYYTNCSQPDQKLSNYHTTRATMGSSFHINRTQNHLKWSKTVPPALTVDSGATVSFDTIDGSGGQITQTSTSADVYNFKVEFADPVFGPIYVNGAEPGDALEIEVLDLETADWGWTAVVPKFGLLSDEFPDAQLKIWELSKFEDRPYALFKEGIRIPTRPFLGEMGVAPGADGEFSTIPPLDTGGNIDCRHLTVGSKLFLPVQTPGALFSCGDGHAAQGDGEICGSAIETPMRATLRFTVRKNHDWVASPHYFSPPLVAIPGFEDRGCYAALGIDSDLYEATRKAVRGIINYLTRTKDLTRVEAYMLASVAVDLKLAEVVDMPNFAVSASLPLNIFHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BC26</accession>
    <name>A0A0D2BC26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236396.1">
        <property type="nucleotide sequence ID" value="XM_016380569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BC26"/>
    <dbReference type="STRING" id="91928.A0A0D2BC26"/>
    <dbReference type="GeneID" id="27333314"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06231"/>
    <dbReference type="HOGENOM" id="CLU_043563_1_0_1"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="39729" checksum="FA45538CAF931F21" modified="2015-04-29" version="1">MPFRANLPPVTRALLAATVALSLLYNIARWRLLQASLDPTTGDEDTASRRVVPYLALVPSQCIRYPWTFLSAAFVEQNVFTLILQGGTLFFGGKYLERAWGTKGFVYVILLASIIPYLLAAPTYLLWASVTGSSDRALTPLNGGITLQAAFLVAFKQLVPEHTVSIYKGMIKMRVKHFPTVFLGVNTISGLILGTDTALILSWYGLITTWTYLRFYKWQPNLSSTSPETGGLRGDASETFAFATFFPDVVQPPIAALCNRIFSLLCSLKLCTPFSDEDIATGNEQAAARGEAGLPSFSRQSRGVRGMSKREEAERRRALALKALDERLNAASSRATAQQATTGTPNLAQGQEILGQTDYRPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BC91</accession>
    <name>A0A0D2BC91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236794.1">
        <property type="nucleotide sequence ID" value="XM_016378117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BC91"/>
    <dbReference type="STRING" id="91928.A0A0D2BC91"/>
    <dbReference type="GeneID" id="27330849"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03766"/>
    <dbReference type="HOGENOM" id="CLU_1610771_0_0_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18590" checksum="DCABB1C507C3A74F" modified="2015-04-29" version="1">MRTSEKVILLYLQARLWSGKKFFGSLGPSVTRVSGCRVNKGPCESAEIEAERYVAQRTSIPVPKVYHTYQVDGRFYVEMEYVKGDTLQALWASGALSPDEKKALVMQVAGYIDQLRMLKPPHKEIVASADLGRCLDYRVGYRPLGPFTSNEEFHPFLRGYIHSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDQ2</accession>
    <name>A0A0D2BDQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236966.1">
        <property type="nucleotide sequence ID" value="XM_016378289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDQ2"/>
    <dbReference type="GeneID" id="27331022"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03939"/>
    <dbReference type="HOGENOM" id="CLU_097609_0_0_1"/>
    <dbReference type="OrthoDB" id="4151907at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="249" mass="28540" checksum="7ED242CF5CAD56FA" modified="2015-04-29" version="1">MAPSGRDYKFLDKDGDDYYHHQHRRDQPYSRFANPPLTCRPKLFCCPVAESSQHHLPRSFVNPGRHLMNQQLRTFLECADDDDYTFHKCEVSHMVEVTTRALCNDLATLPRGVQAQEQWNRLASPLCKSAVDNITPPLECEDSKMSIDQETVPYSTYQSMSTRCFITQNSSNSWQVPPHSRQYRDNHPDPNNGRIGAEKYIEIPPLRTVPYTSESASGNGGGAREWIPSCSILMWCSKHNTFYEVHILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE32</accession>
    <name>A0A0D2BE32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxidoreductase NAD-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237454.1">
        <property type="nucleotide sequence ID" value="XM_016378777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE32"/>
    <dbReference type="STRING" id="91928.A0A0D2BE32"/>
    <dbReference type="GeneID" id="27331512"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04429"/>
    <dbReference type="HOGENOM" id="CLU_003827_7_1_1"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052128">
        <property type="entry name" value="Oxidoreductase_NAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505:SF1">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="311" mass="34591" checksum="0FE63CCAABA9EA08" modified="2015-04-29" version="1">MATVKDSIPHIIRTAEDPRQQGVWTARLSKIEQVNSKIRLLNLSLPREGPPLRHMPGQYIDLYIPNVDVVGGFTITSPPQAASSQHQPNPHIELAIQASPSNPPAAYLWRPVPEILDSTVTFRVGGTFAYPPLSLDRDECANIDRVVFVAGGVGINPIMSMISAMDEVGTKSRLGGMVSAVRVLYTARREHGPNSSSHSGGQAEEEVLFEKRLADVARKWSNHEQVDYRYTFFETSRKGSADAQGTVAGNITYRHRRIRHDDLFQALGPEATRANTVAYVCGLPTMTDEFVELLKKAKGMDEKRVQCEKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE82</accession>
    <name>A0A0D2BE82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab proteins geranylgeranyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237514.1">
        <property type="nucleotide sequence ID" value="XM_016378837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE82"/>
    <dbReference type="STRING" id="91928.A0A0D2BE82"/>
    <dbReference type="GeneID" id="27331572"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04489"/>
    <dbReference type="HOGENOM" id="CLU_021695_3_1_1"/>
    <dbReference type="OrthoDB" id="1923006at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017230">
        <property type="entry name" value="Mrs6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037514">
        <property type="entry name" value="Rab_ger_ger_transf_A_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="505" mass="55102" checksum="EA6E75213E31D635" modified="2015-04-29" version="1">MEFLSDEIWDVIIAGTSIPQSLLALSLSRSGKKVLHLDRRTYYGGRDAALSLQDAERWVEDLEKFPNSIFKDASISKPDSEDAGPSALKSSRSYTLSLNPQIIYAQSKILPTLVSSRIHTQLEFLAVGSWWVHRAGSLHKIPSTREDVFNDESLSMKDKRGLMKFLRYVLQDDVELDTTLEDDTSLSLQSALDTKFKVPASLQAPLLALALSPVPASQIPFNVALLRIRRHMRSMGYFGPGFGAVIAKYGGNSEMSQVACRAGAVGGGVYLLGHELTSLTLVDQDFSGKALLEGTLSDSTNVKARSVAGSPEDLPTTDQATQPGQSKEEFLRSINVVDHSFRNLFPQTSDNGPVPAAAIVLVDEGDNTGSEKSPVYLQIHSEDTGECPPGQCIIYASVRVEADKTSSKHRLESAIQSFLETENASGTLLWSLSYVFSGVSAVANETPTLLRPSPSIMLFPPASQDIAFPDNVLDIVKGAWQSITAPQTDDSSFLRFEEREPEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEH0</accession>
    <name>A0A0D2BEH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7626 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230010.1">
        <property type="nucleotide sequence ID" value="XM_016386202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEH0"/>
    <dbReference type="GeneID" id="27338977"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11894"/>
    <dbReference type="HOGENOM" id="CLU_882876_0_0_1"/>
    <dbReference type="OrthoDB" id="5321209at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056043">
        <property type="entry name" value="DUF7626"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24625">
        <property type="entry name" value="DUF7626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7626" evidence="2">
        <location>
            <begin position="131"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="315" mass="35616" checksum="F44BC2314586FCEB" modified="2015-04-29" version="1">MNLGAQAVIPMRPTLKPANYPRKRDMPAVVTKQSKYPLPYFAHQQLDTAYFPRDIGLPVGRPKVENGENAVWDDDDSDNGADLESDAGEASHPSKTRRKPDFIGNDFKASDVKNMKIRGGRPAIAKKVSADLDSDDELIVRMKEARFLEKDIAQALVDQGRIAYNPKTIGTRWRRIKAKLQKRQDDLLDADLTDWHDGDDDILLQAVIKADAEVDRLKAEIDGRKWRMVADSMKNMKPVVNFSQNACRSRYDALMAGNAKPTPESIPNPTPEILERIQSRLDKEARLARDQQQPNGQQQTNIAGNAWSSRQRHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEZ9</accession>
    <name>A0A0D2BEZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04717</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237739.1">
        <property type="nucleotide sequence ID" value="XM_016379062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEZ9"/>
    <dbReference type="GeneID" id="27331800"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04717"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000489">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="108"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="606" mass="64981" checksum="CAF6572D53306047" modified="2015-04-29" version="1">MGLLNKEPASTGSDPAEHVTSGATTVVPSQNVSNVDLEKELPVETTVAEKSHTSSQKRMDAEKRQTVTGSASSTGDVELQNEKAHEDGEPPFGDEEAVYPAGLKLALITLALCLSVFLVALDNTIIATAIPKITDHFRSLGDVGWYGSAYLLTTCALQLFFGKMYTFFSIKYVYLTAIVIFEVGSAVCGAAPTSNALIVGRAIAGIGSAGIFSGALVIIAYTVPLVKRPIYTGVIGAMYGIASIAGPLLGGAFTDGPGWRWCFYINLPLGAVTLIVIFFFFQSPHRKAEAAVSWKERVNQLDLGGTAVFIVDIVVCLLALQWGGSTYPWSNWRIILCLVLFGILTIVFIAIQFFMKDNATVPFGLISQRSVAAASWFAFTLGAAFFLLIYWVPIWFQAIKGASAFKSGIDSLPMVLALVIATFISGALTTVVGYYWPFYWLSAIFSAIGAGLLTTFDVNTGHEKWIGYQVIYGLGVGFGMQQALMTVQAVLPLDKVPTATALVMFMQTFGGALFVSVAQNVFNNRLIAELPKYAPGVNPQIVVHTGATSLKDQIPARLLEGVQHAYNISLTNTWYISVAMAALSILGAVFVEWKSVKGMKPGAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF45</accession>
    <name>A0A0D2BF45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial distribution and morphology protein 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04788</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237809.1">
        <property type="nucleotide sequence ID" value="XM_016379132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BF45"/>
    <dbReference type="STRING" id="91928.A0A0D2BF45"/>
    <dbReference type="GeneID" id="27331871"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04788"/>
    <dbReference type="HOGENOM" id="CLU_016236_1_0_1"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="80440" checksum="647CA53D9B5F9A96" modified="2015-04-29" version="1">MTDVFVRGIRDVSKFPALATRTTRVTQRLATSSLYRSFRYHTPRRIAVLESPSNSYVTKAAKGLRGSGLLASQAGRLPVGTPVSGAKSSPISYSFQAPASTLGLHLAGRSADPWPQTRLARILKRGFHQSQRRTQKPASRREGIEQEAKNKTSKPEVSQEQSTSRPETGQSQSHHEHFYDRIHMPQFHRPTKEELLAAATGFWSRLKVRFKWLTIKSTRPFNVDEIVGFISWIALGHVIWIVVGTTTFVSLAILAINTVFAQETLAGWIGNYLTKSSGLHVVFESAIVPKWSDGVITFKNVFVSRRPGKSNSRVTKGSPEAAAQASSAEDPVPPEEQNYTQFDITIGEVNVTLSFSKWWNSKGPLQNVEIKHIRGVVDRTHVFWTDEQIDPKSYRHEHNPGDFEIESFKIEDLLVTVLQPEGFRPFPVSIYNADLPRLRKQWLFYDFLGANSMTGEFDRSLFTIHPRQTHSYTGATLQHSDDPSNEPWRKQSRIRIDAMNIDHLNRGAVGPLSWIHEGNVDIVADVMIPNDFEESVMKVMTDFYERMEEALTSRKHVDLISPRDDADSVASDDGGGVLSASTEPKAVREEDKRYLVMDLRIHLNDVRAVVPLFTRDLSYINNALIRPIVAYINSRRTFIPINCRVVKRLSDFDGSWTVFDSGLMDDLSAEVYDAFARDVTDEQARLRRFKKVGLWSLQLAVQAIFLGMAGNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGM7</accession>
    <name>A0A0D2BGM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238001.1">
        <property type="nucleotide sequence ID" value="XM_016379324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGM7"/>
    <dbReference type="STRING" id="91928.A0A0D2BGM7"/>
    <dbReference type="GeneID" id="27332063"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04980"/>
    <dbReference type="HOGENOM" id="CLU_025396_0_0_1"/>
    <dbReference type="OrthoDB" id="4226666at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF5">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="78037" checksum="42C6F1B5705DB901" modified="2015-04-29" version="1">MGRRRRQSGHRQAQLPFLRVEPKPVGVSSTPATFAHRPRQRYSSIPPEELQPGAPQHRYNEATAPSSPVSSRSAHSHGSLGHSVSTSYTSYLADARHLSPDPPTPTNSTISTYNSAHHATNGSGRPRQYQSFMSSGTSDPDVQMTDVLGIDVRFSSAETQQYVGSQPQYVSDRGFSPTTHQRYPHMAGPWAPLPFRHEDLYMGEEGAGPVREEVVPEDAQTQSSREKRGGRTRPLSPSARKEASDVRRVGACLRCTIMREKCDLQTSCHTCLTKERRKFPKTCIRAHADWERLKSIIFPLELTSSLRRDKLFRYMSKGAFTLSPRQPFKIPLDLGVGTPLQVMVQEFHALTTEIEHTYRIKEDGSGNKIYCQHQVWSPPINVFFKNGEYMRPVQSLKHQINTIFENVLGDEKGWINWTMEYFPSKEENFQTDILGWIGKYYRKDIHEHGILKTGLSLLWYEHLLLRSFEIPPEARPMLEKHLESCRPAELSEKAEIAPETINRFLKGVILPMAEDAARSVLETLHEKMFKMAVNLDLSKARTDIALCLAFILLIFLGRTQHALVLLASTSAKESDGMYSLSDAKAKIQEMEDSVTEYLLSFHKYTLSRKSSRSAKVSSGGGEERSAFEMHARDFDLVGRFRGEVGVEYAGIKPEDLDVGPLNYKTFRHMNVRRLCWKLFQNFDVDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGN6</accession>
    <name>A0A0D2BGN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230695.1">
        <property type="nucleotide sequence ID" value="XM_016385751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGN6"/>
    <dbReference type="STRING" id="91928.A0A0D2BGN6"/>
    <dbReference type="GeneID" id="27338526"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11443"/>
    <dbReference type="HOGENOM" id="CLU_033346_0_0_1"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="347"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="580" mass="62145" checksum="3022A3D5B36377AD" modified="2015-04-29" version="1">MATPPENPDSTSNFKIEDGNVADNNPHPLISGTSQATASSSVPVTSGFDNPNTLEGTIIVQHAASSQHSSNASHFVVSEAGASGPRRGSSPNILPHGHTIPPSLDWGTSNGEGTGDINSNDQTVYKLDKDELHTDSDPDFRHSRGSFAALPPSGAMPSFAHTTDSVANNADGTNTSINRPTTSGVSEEIYNDSSTRKSKQYVLSDGSVVSGKGLGRGRPGVKRGPRTTKDKSHEGIPLAAPDTSTGGLEQPSKKRKSADGNTMNARSTTADSATTQSRESSEEYNPTGHTRSGRQTQKPVNLTNENTASASPSKPSRAGFNHTPTPSASAKTHPKIKRRIYRGREQFALCEHCLRGHGPPGNVIVFCDACNKCWHQRCHDPQISKQTVSDAKAEWYCTECDRILHGKKAKKINTKTKVAPVPPVVPPTPVYAGTRVGGRFLLPDQKLAYLHTLSKENLISLLMHASDLAPDLPIFQTLVTPAQPSTVPQAQFTSTYVTPVTDTPTSRDADGGDAVDEGYDGYYDEHAALYPKPGNGIRLPPEREDLHMLLEGKDSKTFSHWVRGMPGNDYSGSGNVMNRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BH07</accession>
    <name>A0A0D2BH07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238499.1">
        <property type="nucleotide sequence ID" value="XM_016376929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BH07"/>
    <dbReference type="GeneID" id="27329654"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02571"/>
    <dbReference type="HOGENOM" id="CLU_813899_0_0_1"/>
    <dbReference type="OrthoDB" id="4120991at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="341" mass="37755" checksum="F33719738AABEF16" modified="2015-04-29" version="1">MSSSEPPAQHGLESRLETLRKAYADLQEENVKLQKKNDMLVHEVSTLREFCLQNGLAPKWENDKSNETDDADDDDDDDEEEEEEEEEEEEDHLTLAVPSTPPSTPTHHYPPQRPRARDPRLVELGVTFQIIPANGTGETEHTTHSFQLNAAECSSIRQFCQRVAHAIPEECTGKAELTGAPQSDSASEPESGPEPMSVPDGKAEPEAEASRAPPPPPPPPPPSSSSSSGEQEEVISPEFSAQIKSTFYPPLSATRFYPDLSRATIKLEEDGHVAEFTVTPTTLDKVTPWPELQYHAWYERNIVRGRGDKAEYMVNVKMRECGSGSQKTQCVGRGSRPPESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHQ3</accession>
    <name>A0A0D2BHQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spermatogenesis-associated protein 20-like TRX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238371.1">
        <property type="nucleotide sequence ID" value="XM_016376801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHQ3"/>
    <dbReference type="STRING" id="91928.A0A0D2BHQ3"/>
    <dbReference type="GeneID" id="27329526"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02443"/>
    <dbReference type="HOGENOM" id="CLU_014051_1_1_1"/>
    <dbReference type="OrthoDB" id="1923667at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="2">
        <location>
            <begin position="11"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="771" mass="84668" checksum="90B64EAA3CDE8C8A" modified="2015-04-29" version="1">MVEGNAGLHLQNALAESPSPYLRAHKDNPVAWQEWSDATLALAKQHQRLIFLSIGYHACHWCHVMEHESFSSPEIADLLNEFFIPIKLDRETRPDLDDIYMSYVTATTGSGGWPLNVFLTPDLKPVFGGTYWPGPSPSSSVKQATPAGDDAPVTIIDILHKMRDVWTNQREKCIQSSIDITNQLRAFAAEGIHSQTNTQSQGNESDTAEPLEIDLLDDALEHFISRYDSVHGGFSASVTAPKFPTPSNLTFLLRIGAAIAQPSTHTRFGFFSPVPGILGTPSCTKAASMSLHTLLAMSRSGLRDQLGYGFHRYSVTPDWNLPHFEKMMCDNAQLLGCYCDAWALGRDPEILGTIYNLVEYFTNSDSPIVAPQGGWYASEDADSNPSLPKLANGVPASEDKKEGAYYVWTYKELQAILGERDAAIVARHFGVKLDGNVPAEHDIHDEFLTQNVLHIEATPSVLAKEFGVPEEEIVQIIKSGRTKLLEHRKSKREHPSIDTKILASWNGLAIAALSRAANTLATIDKTRARACQEAAEKAATFIRREMYDESTGRLSRTPDSQAAFVDDYAYLILGLLSLYDLTLAQPYLDWAIQLQKYVDGHFASTTGGYFQAEASAEQIIRLKPGTDNSLPSPNGIICTNLLYLASYCQSASPSTATTADGHNYLGKAKGILDAFAVEIIQHPFLFVSLLACVVMQEVGAKTLIAPMTTRDSELRRLKGWGRTVVKGLVPEVMICTREGVCRPLKQSDLEDVDDEPDEGVVGASVDTTSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BI13</accession>
    <name>A0A0D2BI13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_02871</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Integral membrane transporter that imports quinic acid to be catabolized as a carbon source.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238799.1">
        <property type="nucleotide sequence ID" value="XM_016377229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BI13"/>
    <dbReference type="GeneID" id="27329954"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02871"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="26"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW18583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="536" mass="58949" checksum="4FA04F32357ABCB2" modified="2015-04-29" version="1">MRNPFAANEDRSDAPREIFGYRIYLLALSATWASSMYGYDSAFIGGTLALPSFKHSYGLDTVGKTELLDLSSNIVSTFQGGAFFGAIFGFFLSEKFGRKPIIMVSGVVFSLGAVLQLIGKIGLLYAGRALTGLGIGASATIIPIYISECSPASIRGRMVGFFEIMLQIALVFGFWVNYGVNKNISATNPAQWRIPVGIQLIPAGLLLCFMPFMIESPRWLLSKNKMEQARKSLSWVRNLPQDHEYLDRELTEMAAGVNHELELTGVGMGKSQMLREIIRPGIRNRVILSVLLMLLQNLTGINAVNYYSPIIFKAIGISGTSVGLLATGVYGLVKMVTTVIFMVFIVDTVGRRISLLVGSVGAAFAMFYLGIYSKVSGSFNHTPPRDAGANGAIAMVYIYAVFYGFSWNGIPWIISSEILPTRVRTLGMMCAVCMQWLAQFMVVYSLPHMVASITYGIFFFFGACTVVAMVFAYLFVPETKGVSLEDMDLLFDKDSSVWAKNSYKKYKELKEAGLNATTIHAAQVKETTQVVELEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIA0</accession>
    <name>A0A0D2BIA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231295.1">
        <property type="nucleotide sequence ID" value="XM_016384693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIA0"/>
    <dbReference type="STRING" id="91928.A0A0D2BIA0"/>
    <dbReference type="GeneID" id="27337461"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10378"/>
    <dbReference type="HOGENOM" id="CLU_027981_0_0_1"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF416">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE GODZILLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="315"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="510" mass="57017" checksum="E1DCF83047090C78" modified="2015-04-29" version="1">MQEDELYTKNRLTSWKRTYGLQLRASGLVRTLSQNNPNNYGTIEGLLYVPDLPPSDPCDNATRALIPSNVTTRAQIPGQKYPLIALAPWTQTACVESYLAAMASDNVRGGIFFHPGNESEQPPPVSDPSWSLNDGGNWKGENPYPVYAIPGMLGAFLLDELAQYSGNLSSSPYGKELEDLYDSHDVVRLVARIDVSVTGGIPSLWVFLIIVLAVLLAVVLVTSVIMHWVQRKQRRQLQQRVARGEVDLEALGIKRLNVPQEILDKMPQWIYISSNNDSNGETGLNESVASAEKNSTDTTISAKAVREAPFSQTTCPICLDDFVHDETTVRELPCNHIYHPECIDPFLRENSSLCPLCKKTVLPAGYCPVQVTNIMVRRERLLRRTRQRDAEDNLAVNGSRLPGVTAINRTMRQFSNPLTASRHQHGSAAGEHTTGAEMQAPPQRQQTQVDDEMPAEIRAQGTSARRAWRRERLARQQAREYGQQADQARVVDESRPLWRRIVGRVFPSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJZ5</accession>
    <name>A0A0D2BJZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239459.1">
        <property type="nucleotide sequence ID" value="XM_016377889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJZ5"/>
    <dbReference type="STRING" id="91928.A0A0D2BJZ5"/>
    <dbReference type="GeneID" id="27330620"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03537"/>
    <dbReference type="HOGENOM" id="CLU_010194_13_0_1"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF33">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="331" mass="36451" checksum="E5C887C044953AD0" modified="2015-04-29" version="1">MKAKSTHPLWFIRQTCVSGCSGIGLGLVKHLLSKSDEEWRVVVADLRPEAYEKVKSELDPARHKFIETDVASWDSQLSMVKEAFSWSGVGRIDFFAANAGTTEGEHLLDPTKDDLDADPTMPSMRCTQVNQVAVFYGLKMFLHYARVTNRALKAGGAGSGEQQQVKVPYNPKFVITSSCSALYPFPIAVQYAATKASLVSLVRSIGKNLLASDNVAVNCIMPAYVDTGLTPSEVTALWPPEWVTPLSTMNRAYDELISDDGTVAQDGKSDGRDGSVKAGKCVECVVDRLYYRRGVDFADESQRFCIEESFRPDGVWMRGMMEMVRKGAYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKK2</accession>
    <name>A0A0D2BKK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239679.1">
        <property type="nucleotide sequence ID" value="XM_016374403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKK2"/>
    <dbReference type="STRING" id="91928.A0A0D2BKK2"/>
    <dbReference type="GeneID" id="27327118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00035"/>
    <dbReference type="HOGENOM" id="CLU_042529_4_2_1"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009668">
        <property type="entry name" value="PRK13189.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF9">
        <property type="entry name" value="PEROXIREDOXIN PRX1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="49"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="263" mass="29302" checksum="B7B1F3E8D622AC7F" modified="2015-04-29" version="1">MASTYSRSLFRAFAPALRAQRAHGSRPRCAPFANSFRGYAAAAGEQPRLRLGVTAPNFQAKTTQGEIDFHKYIDGSWAILFSHPADFTPVCTTELGAFAKMRNEFEKRGVKMIGLSANDLNSHDAWIKDINDISNTNLQFPIIADADRKVAFLYDMVDQQDLTNIDEKGIAFTIRSVFIIDPQKKIRLVMLYPASVGRNSAEVLRVIDSLQTGDKKGVATPIDWQVGQDVIVPPTVSTEDAKKKFADVREVRPYLRFTSGQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKL5</accession>
    <name>A0A0D2BKL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_09087</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232030.1">
        <property type="nucleotide sequence ID" value="XM_016383407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKL5"/>
    <dbReference type="STRING" id="91928.A0A0D2BKL5"/>
    <dbReference type="GeneID" id="27336170"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09087"/>
    <dbReference type="HOGENOM" id="CLU_047148_1_2_1"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW11814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="391" mass="43522" checksum="B2C8217E3B355133" modified="2015-04-29" version="1">MELPPVLQASKRALLARPAVSRVLLYSRQPCLRLHAPITRWNSTKADVSTPFPVFRDVPPLRQVRKKMFREGKEVGFVATMGALHEGHLSLVKHALQENTDVFVSIFVNPTQFAAHEDLDSYPKTWEDDLQKLKQIQDEHAASAGPNSGSKIRGIFAPTVKVMYPTLPPSSDIAGHGSFVTITPLGNQLEGSSRPIFFRGVATVCTKLFNIIQADRVYFGQKDIQQSVVIKRMVKDFHIPTEVRVIPTSREADGLAMSSRNVYLGERRREDAVVLSKALFAARDLYNSGELSGKKIRDAAYEVFAQESMLRRKDGKLGGSCQIEIDYIALSEPQNMAMIPDFAKVDPSQGAILSAAVYVQPVDEPRTEKEVGQRVVRLIDNVILEPREKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL82</accession>
    <name>A0A0D2BL82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239934.1">
        <property type="nucleotide sequence ID" value="XM_016374658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL82"/>
    <dbReference type="GeneID" id="27327375"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00292"/>
    <dbReference type="HOGENOM" id="CLU_419218_0_0_1"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="617" mass="69303" checksum="BC2460B1D31ADC86" modified="2015-04-29" version="1">MSSSDVASLAGTWVGAGVALMALITIIGPILVWRASLTKRHKALAAIGRNNNRYLSDGIPFWPGIRFFRVLRMPQTAVLRNFTDEEWGDFDLGKLKTPPESPATWVQFGACLEAYGLRMKYTKDSAMHDGHFALPVHRSYLFNFLVLGRYREKELKKRPHTLGERRMSLRLSLSRSNTQSLRPSWSLHGMTGTLLFETKSTHNPTLSGKVQFTQSLENCETKIPRDKLSRLSILLLVYGCLHLASGRYICCIIGQYDHPQVSPDSDSESDSGPRFRVASIQRRLTMSTYGSETQRKADKVLEKLKIAVYILQPVPLEEGDFPLGVESCSMEVYVLHPVESTPVLQEKLLELAGMTFVPPVEPYVRVYTDDKGRSSRSRLNSSELTEWNLAFLKRESAQLFAFALLTMPWSPRNYVLSKGDNKSLVGVLLSEAGASCVRLLLRLKNNAGSLSMELAKKTKLLAAIDKALSSKFDVPDLCDLDERLASLQHDVVELPLMVGVLVLTNEEYRELIYQSTRHLDKTAKSPDVETEFDLDTGNVTVSGPFGVKHVFVVDLAELTQHLPDHVPSQRRIFRIDHATILLAAVKAHLRSLLFSECIDGSDIQRVMNYEEDVYLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLE2</accession>
    <name>A0A0D2BLE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_03685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239606.1">
        <property type="nucleotide sequence ID" value="XM_016378036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLE2"/>
    <dbReference type="STRING" id="91928.A0A0D2BLE2"/>
    <dbReference type="GeneID" id="27330768"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03685"/>
    <dbReference type="HOGENOM" id="CLU_397414_0_0_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF804">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="211"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW19390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="693" mass="77980" checksum="C55ACDB0DDB78EDB" modified="2015-04-29" version="1">MYGQTSIPDVPGYVSFRAGHRIQSRKILTGDEAKPTFDAIPSIDASQIFSEDFQERKRLAEQIGKAAQDVGFFYLINPPVSGAKMDAAFAALARFFALPEDVKMKYHVNNSPAFKGFNPVNPDEKRAGFGSARETFSLGRDYTDPEQHSIKVAPPGTVSLNQWPDADLPEFRRDIYAYFTEVYAFAAKLVQIFSLALGLEETALDEFFKFPFTDITINHYPPQAGDDTYRQVLFPHADYGAFTLLAQKEVSGLEVLNANAIWVKAPVVEHAFVVNTGSYFELISGGRWKSTVHRVCARANTDRTSLPFFFSPSPNTTIYPMVALEDNDLEDQLTYDLSGIPYLGSKPEQSPYLLYVRPLTNHVPPLRYAVAAAAACHVAIRFQNDSLKARSREWQLKAMELMRQRLTSKALTADFGTVLTILMMAQNDMCTGDCAEFDTHLPAARAFVDEHGQNLPDRGYCEQRLAWLDIIRSTTSDHFLTFTSPDLKKVFSRYRSASGHAREWGHEAFACPIDLLEYIVDVTVLYKIQPRGQLFSQAAIEKASLFLERVRGWTPRPGYYSEQMGHVVRAWHAGVQLYVIRLFRLHQHGCGEGDAAIQTTELVETVLAQAKAVKTPSAWSHASIWPLFQAALWFEEAEHLERRQWLLDYFQMIMRTSGCNQLDVAASTLKTIWKSGEYYDSVTAGNITGSLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM70</accession>
    <name>A0A0D2BM70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_00274</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239916.1">
        <property type="nucleotide sequence ID" value="XM_016374640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM70"/>
    <dbReference type="STRING" id="91928.A0A0D2BM70"/>
    <dbReference type="GeneID" id="27327357"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00274"/>
    <dbReference type="HOGENOM" id="CLU_002976_2_1_1"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239206" description="P/Homo B domain-containing protein" evidence="18">
        <location>
            <begin position="20"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="491"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="654"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="789"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW19700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="857" mass="93711" checksum="10D0E8E85086AED8" modified="2015-04-29" version="1">MRLPSWLSLLILASQTVASQRDYERNDYFAVHLSPAADIREVARLFGVKHEGQIGELSDHHTFSCPKGSCPDFEASLNELKLRKKRRKRGETGLHERNSWRQLSAELGGILWAEQQYLRHRHVKRIPPPGPLVPRQETAGDGTDAEKQEAIQRLDSIAEALDISDPIFKEQWHLFNPVQLGHDLNVTGVWLDGITGNGTISAVIDDGLDMDSNDLKDNYYAEGSYDFNDKGPDPKPRLFDDKHGTRCAGEIAAVKNNVCGVGMAYDSKVAGLRILSKPISDEDEATAINYHYQENDIYSCSWGPPDDGATMEAPGILIQRAMVNGIQSGRGGLGSVFVFAAGNGAASEDNCNFDGYTNSIYSITVGGIDRAGNHPYYSEACSAQLVVTYSSGHNDAIHTTDVGVDKCYTGHGGTSAAGPLVVGTVALALSVRPDLSWRDIQYLCVETAIPIHVEDGSWQDTTIGKKFSHTYGYGKVDAYRFVEAAKSFVPVKAQAWYHSPWLSVQHKIPEGDQGLAASFDVTQEMLNEANLERLEHVTVTMNVEHGRRGDLSADLISPGGVVSHLAVTRRPDVAASGYDDWTFMSVAHWGESGIGKWTVIVKDTHENEFNGTFVDWRLNLWGESINELTQGLHPLPDEHDDDHETASAIVSTTSVLAAPPPTSLPAKPTNHIDRPTKPKPGDDSDTTATVSSISAVSTTDAFSTTSKVSDPATTTTGAVEATHTYSDSFLPSFFPTFGVSKRTQIWIYGSIGLIIVFCAGLGVYFVLQRRKRLRNNPRDAYEFEMVGDADEDEQQGVNARRTRTGKGRARRGGELYDAFAGESDDDDLFSDEDAYQDTPSNDTSPGSRGDSPAEREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMH9</accession>
    <name>A0A0D2BMH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232590.1">
        <property type="nucleotide sequence ID" value="XM_016383967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMH9"/>
    <dbReference type="GeneID" id="27336734"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09651"/>
    <dbReference type="HOGENOM" id="CLU_1124554_0_0_1"/>
    <dbReference type="OrthoDB" id="10365927at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="247" mass="28353" checksum="1DE83DD40D5DFE3E" modified="2015-04-29" version="1">MLAALSTLRNPLRAVMGCTQDDKGTVGGADSQDETSIHHQPGLSHSQSAATSSNAGETSQNPIDLEGYEIIERPTPTAGSSRPSGRRSRSERVIRSPGALKSVLQQRFFIHRLKSNIIRQQKEMERRLLRYVYTRDPLAFTLFENAAWNWVTGIKAIRPYSKQYNNARVNQLKGWAERLRSSAEKRNEQLSTTFLTTELQHLDLQKMGNHFAELRHMVQFTQELERIMQSWVFEESMELFREWTDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMJ8</accession>
    <name>A0A0D2BMJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240374.1">
        <property type="nucleotide sequence ID" value="XM_016375098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMJ8"/>
    <dbReference type="STRING" id="91928.A0A0D2BMJ8"/>
    <dbReference type="GeneID" id="27327816"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00733"/>
    <dbReference type="HOGENOM" id="CLU_013985_7_1_1"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000058">
        <property type="entry name" value="N-acetyltransferase (Nat5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="189" mass="22003" checksum="F36D81C5AB894B1F" modified="2015-04-29" version="1">MPIIRRVQPSDLLHLNLCNLDPYTENYDLNFYLTYLMRWPSLFQCIEEHGQIVGYIIGKVETSPAQLQGTPHYLPWHGHITALSIAPQYRRFGYGKLLSESLEKACNQQNAWFVDLFVRKSNTNAIKMYESMGYSTFRTVVRYYADDPTGVSQDGEDALDMRKPLDRDKDRIHVRENGESFKVDPEDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMK5</accession>
    <name>A0A0D2BMK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240384.1">
        <property type="nucleotide sequence ID" value="XM_016375108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMK5"/>
    <dbReference type="STRING" id="91928.A0A0D2BMK5"/>
    <dbReference type="GeneID" id="27327826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00743"/>
    <dbReference type="HOGENOM" id="CLU_092550_0_0_1"/>
    <dbReference type="OrthoDB" id="5427070at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="230" mass="25924" checksum="724CEF0DF50F3CB5" modified="2015-04-29" version="1">MVMDYLFPRSIPGNIASTEAAPPVQAEVTTTTTSTIDSNKMAGSGFLNFTQTVLIPIFIAAALYLVVFHALLPLYRRHRARYSQYLPLQSTSLTSHLPDALQPSSVRDRMTGAFMRLFLPSTWAFRTRFRRRDSVVSADGDLFDVESGEAMVGFDVQERDQRRHGMERQVSNMAAATRTANQLQDAAMDSDQRLNRELEEGFRDDSEDEGEREAAREVVVGRRSQSARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNC2</accession>
    <name>A0A0D2BNC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232840.1">
        <property type="nucleotide sequence ID" value="XM_016384217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNC2"/>
    <dbReference type="STRING" id="91928.A0A0D2BNC2"/>
    <dbReference type="GeneID" id="27336985"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09902"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="184"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="322" mass="35661" checksum="7F5A948329538AE5" modified="2015-04-29" version="1">MAISYEPSPAFIIPTVDLTAYLNDPGSPEADQIVDRIRSACATSGFFQITGHGVSRSLQERAFAAAKKLFALPDDVKRTLTGVPGRGYEVLGSQVLEEGKKPDLKEGYFVGREIPGNKAPFRRFQEANIWPDPTLLPESDFKDPLLEYHEKLSELSFHVTSILFRGLSLSQFDTSLFADFCKDPIATVRLLHYPPHPPLADPNLVGAGAHTDFGALTLLLQDGHSGLQVLKRTPDQQDQWIDVPPQKDAYVVNIGDFLESWTGGAYKSNVHRVINTSGTDRYSIPFFWDGNADCVIKPLDGSTGKEYTVEEHMLSRYAKSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNK2</accession>
    <name>A0A0D2BNK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240326.1">
        <property type="nucleotide sequence ID" value="XM_016375050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNK2"/>
    <dbReference type="STRING" id="91928.A0A0D2BNK2"/>
    <dbReference type="GeneID" id="27327768"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00685"/>
    <dbReference type="HOGENOM" id="CLU_070703_0_0_1"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="233" mass="26770" checksum="06B6358AAD6E073A" modified="2015-04-29" version="1">MGSDSPEDFWLFGYGSLIWKPPPHFDQRIPGYIQGYVRRFWQLVLNNFPSEDHRGTPEAPGRVVTLIEKSFWETLDDPQRHTEKDHVWGVAYHIIPSKVREVQEYLDIREINGYSIQYTPFHPADSNLPDIHCLVYIGMPDNPQFLGALHPQDIAETINSSIGPSGENREYLLHLEKALESLSTNSHDEHITDLARRVRALAPPVRLSQLQGSTYALKRVSSTEEQEEIEKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPJ4</accession>
    <name>A0A0D2BPJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053328">
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    </dbReference>
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        <property type="term" value="P:intracellular potassium ion homeostasis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF2">
        <property type="entry name" value="CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="25"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="480" mass="53305" checksum="EA8BC7995471903E" modified="2015-04-29" version="1">MAWPEIEPSRSHLTYLLLSFFLIFYALFSELIRNRLHLSEPPLATLTGIIFGPRGLTVLNPFEWGWEDNITQELTRVVTGVQCFAVGVQLPAGYVKRHWRSIGLLLGPNMIAGWLVATIAIRFILNAAWNTAFITAACLTPTDPVLSASVIGEARFSQRVPRRIRHLLTSESGCNDGTAFPFLYAALYATVANSSGKAVRLWVTNLLLWQCGVGIVVGVVLGFVANKALRFSEARGFVQESTLFVFYFLMAILCIGVGSTLGLDDFLVCFSAGTTFCWDGWFWTRTAKMKLPDILDLMLNSTMFVYLGSLIPWRLYRHNLAAWRMGCCTLVILIFRRLPAIVALRRWTPDIRTWHEALFVGHFGPIGVGALFLAIEARARLETGTSEPLPHPPSNAPHQESLGTVWPVVSFVVLCSIMVHGFSPLVMSLAIHFSRDPEERAPLLGAEEERLFGMASNEDENPAGQRTLVEVSEEDSAEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPM3</accession>
    <name>A0A0D2BPM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240691.1">
        <property type="nucleotide sequence ID" value="XM_016375415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPM3"/>
    <dbReference type="STRING" id="91928.A0A0D2BPM3"/>
    <dbReference type="GeneID" id="27328133"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01050"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_8_1"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="95"/>
        </location>
    </feature>
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        </location>
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            <end position="163"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="369"/>
        </location>
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            <end position="411"/>
        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="473"/>
        </location>
    </feature>
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        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="74"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="518" mass="57022" checksum="8DD904A7309EBF79" modified="2015-04-29" version="1">MGPSTSEKQSNTHLESIEQDGAATIVQIEANPGGEAAMDVDKNVKVASDGHTVLVPQPSEDPHDPLNWPSWRKHAILLSTGFFAFSMDFPVGAGISCVFLQSSEFGMTPVAINRANNYSVLLVGFGGFLLMPLVTSWGRVPLSFWSIVAGTFFTLGCALAQTWETYLAMKCLQAFALSTGLIAGLAFITDMFCLHERARKIGIWTAMWMLAPYLAPMLANFIVTRTGNWRNVFWLIFAMNALCILLVLAFFDETWYQRDVPMEEQPTRGPRLFRVVGIWQLTHKKYFPNLWAGYRRLLAVFLCPVVLLVSVSTGITVMWVIGINQSSALLLSTPRTQGGYGFSKDALSYMYFAPIIGILVGGVVGRFVIDLASNRYVRRHNGVYAPEARIPPVYFATFFMVPGLVLLGQALAHRLSWVAIAAGWILYVVGGIMSTVATTAYLVDSYATASAEISIILNFARLIGGFTISYCQVDWGTKVGYNNSFGTQAGIVVFSTLIMAGLHIYGRKLRSVDGLINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR07</accession>
    <name>A0A0D2BR07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016383142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR07"/>
    <dbReference type="STRING" id="91928.A0A0D2BR07"/>
    <dbReference type="GeneID" id="27335903"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08820"/>
    <dbReference type="HOGENOM" id="CLU_052528_0_0_1"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="118"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="303" mass="34795" checksum="B151CC6F462EE38D" modified="2015-04-29" version="1">MIGHALLRWKAAGPVLLLIFVFSVLLLLRDVGPLPSIAVDFDSGPQDQPEPVATTGSGPTPSPTSPPDPDRNKYFHEPGMSDLTRHYDSRYFKEVVTEEERQETLTHLIQSYFDTFQKLGVETWIAHGTLLGWYWNGKILPWDWDLDTQVSDHGLRTLAETHNGTTHRYPPSNGRPERRYLLDVNSWSWQREHGDGANIIDARYISMDTGLFVDITGLTELEPDTKPGIVMCKNNHEYKMEDIWPLRVSVFEDVRVKIPRHYEAILADEYSQEALVRTEFNGHVFDPKVKEWVRVDDNSTVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRU6</accession>
    <name>A0A0D2BRU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thiamine thiazole synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Thiazole biosynthetic enzyme</fullName>
            <ecNumber evidence="6">2.4.2.60</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:55708"/>
            <dbReference type="Rhea" id="RHEA-COMP:14264"/>
            <dbReference type="Rhea" id="RHEA-COMP:14265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">During the catalytic reaction, a sulfide is transferred from Cys-225 to a reaction intermediate, generating a dehydroalanine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the THI4 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.60" evidence="6"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241346.1">
        <property type="nucleotide sequence ID" value="XM_016376070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRU6"/>
    <dbReference type="STRING" id="91928.A0A0D2BRU6"/>
    <dbReference type="GeneID" id="27328793"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01710"/>
    <dbReference type="HOGENOM" id="CLU_053727_0_0_1"/>
    <dbReference type="OrthoDB" id="410463at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160205">
        <property type="term" value="F:cysteine-dependent adenosine diphosphate thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03158">
        <property type="entry name" value="THI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027495">
        <property type="entry name" value="Sti35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00292">
        <property type="entry name" value="sulfide-dependent adenosine diphosphate thiazole synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422:SF3">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01946">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="304"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Cys)" evidence="6">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="337" mass="35837" checksum="BD287C88BB3B7C00" modified="2015-04-29" version="1">MSPPIATFNEFDDGYKAAGEVNKKSLDGSVKKLAVLNGAADVQGTTKLLDDFGGKWDGFRFAPIRESQVSRAMTRRYFADLDRYAESDVVIVGAGSCGLSTAYTLAKARPDLKIAIIEASVSPGGGCWLGGQLFSAMVLRKPADAFLDDIGVPFEDEGNYVVVKHAALFMSTLMSKVLAMPNVKLFNATCVEDLVTRTSADGGIRVVGVVTNWTLVTLHHDNHSCMDPNTINAPLVISTTGHDGPFGAFCAKRLVSMKAVEKLGGMRALDMNSAEDAIVKGTREVSPGLIMGGMELSELDGANRMGPTFGAMVLSGVKAAEEALKVFETRRAECAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRW8</accession>
    <name>A0A0D2BRW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241376.1">
        <property type="nucleotide sequence ID" value="XM_016376100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRW8"/>
    <dbReference type="STRING" id="91928.A0A0D2BRW8"/>
    <dbReference type="GeneID" id="27328823"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01740"/>
    <dbReference type="HOGENOM" id="CLU_019101_0_2_1"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="23"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="342" mass="38065" checksum="6518FAF8974AC4DF" modified="2015-04-29" version="1">MANEFNTEAFTLLAIGVLIVAIRTASRLSVVGLKALWLDDYLMLFATVIYGLETGAAYIVGAWWLGLANNGMTDEQRRTLDPNSQEYRYRINGSKTQLIGWSLYTLLLWTLKLCMIIFYHRLTEALEYMKIRIRIGYGVVIVTYLVTELSILLGCHPFHKNWQIFPNPGNHCQPAISKIDLYVTVVLNVLSDAYLLSIPIPLLWKADVPMAKKLSLIFIFSGAVFVMAAGILRVALIIADPVGGAQAAGSWAVRETFVAVVVCNLPLVYQGGRRLTKAATASGLFSRSSASRTGCSKSSEETALELSARRDSVRRKEFDARQKEMQQEFLASEAPWRFSAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRX1</accession>
    <name>A0A0D2BRX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_01745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241381.1">
        <property type="nucleotide sequence ID" value="XM_016376105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRX1"/>
    <dbReference type="STRING" id="91928.A0A0D2BRX1"/>
    <dbReference type="GeneID" id="27328828"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01745"/>
    <dbReference type="HOGENOM" id="CLU_035836_0_0_1"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1180:FF:000001">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="416" mass="47119" checksum="7137610F49DA5653" modified="2015-04-29" version="1">MAPSRAPSALLLQSLRSLAVENSACGTAVRTLSTTSPARQDAEVQRTSFYQNPDPATVFVPRLERKLMKAGHPPIGSRRRRAALAQSPGIPFDQLPYQCFQEARKILIEDRAEKLKKIETERARIARLEAADPATFRGGEAYKQKRLKSMRAELEELKILADINDPNVKRRFEDGKGDMNKPIYRYLAERKWREYPRKILVQRITQMNVVPDVIPQCDPILDVKIAFGRKAVPPGEFVRSDISENPCQLTLQTFERGEKLVSIAVVDADVPNLENDSFDSRCHFLASNVPISVTEPLVDLGKLSADNQVLLPWLPPHAQKGSPYHRLSIVIWQQKDNIPIDLEVAKSKIQREDFSARGFMSRHLLTPIGASLFRTQWDETMAGVMQRAGLEGADVELKRKKVEPLPYKRRNPPSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSR1</accession>
    <name>A0A0D2BSR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_07101</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234535.1">
        <property type="nucleotide sequence ID" value="XM_016381433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSR1"/>
    <dbReference type="STRING" id="91928.A0A0D2BSR1"/>
    <dbReference type="GeneID" id="27334184"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07101"/>
    <dbReference type="HOGENOM" id="CLU_023861_5_1_1"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000065">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="291"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW14319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="425" mass="48326" checksum="CA3828D9CAE2BED9" modified="2015-04-29" version="1">MSWKPSEKLMSTISHYASFPPTSVSLRQMVQFGEKPSTGTLFRASQFLSEELPVRLAHRVEELDRLPDGLNDMSSIQKVRNWYAQSFEEITTMPRPELDADTRNRLLNPPKKASNRLSVTTRNPSLRYDDNGNGKSSLNSRRYYAATDDGQEWPPGLAEYNRKFARTLDLIKRRHDPVVTTVAQGINEWKRKQQRTQIDSSIQSFLDRFYMSRIGIRMLIGQHIALTEQQTHRHPNYVGIICTKTNVKELAEEAIENARFVCEDHYGLFDAPKVQLFCNPNLNFMYVPGHLSHMLFETLKNSLRAVVETHGADKEEFPVTKVIVAEGKEDITIKISDEGGGIPRSAIPLVWTYMYTTVDTTPELDPGFNASDFKAPMAGFGYGLPISRLYARYFGGDLKLISMEGYGTDVYLHLNRLSSSSEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BT15</accession>
    <name>A0A0D2BT15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241756.1">
        <property type="nucleotide sequence ID" value="XM_016376480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BT15"/>
    <dbReference type="STRING" id="91928.A0A0D2BT15"/>
    <dbReference type="GeneID" id="27329203"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02120"/>
    <dbReference type="HOGENOM" id="CLU_010194_4_3_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="66"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="313" mass="33754" checksum="26A1DCDAE266EAD4" modified="2015-04-29" version="1">MSDKPQQGPPTAYPSTSLKKQDQEGSKGLDAKLEPGANWTQLEFWDDEGTSPYLKDYEGRGLLKDKAVLITGGDSGIGRSVAILMAREGADITIVYLEEEEPDAKWTKSQIEKAGRQCQLLALDITSEDNCRKAIDAHLSKFGKLSVLVNNAAMQEICEDHSQIDLGVVERTFRTNVLSMFAMTKFALPHMKRGCSIVNSCSVAAYMGNPKLVDYSSTKGAISTFTRSLAQQLAPKGIRVNAVAPGIIWTPLQPATKGNPPEAMDSLGVSEAPLQRPGMPIEVATAYVFLASPLASYFTGEVIHGTGGIEMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BTH1</accession>
    <name>A0A0D2BTH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234730.1">
        <property type="nucleotide sequence ID" value="XM_016381628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BTH1"/>
    <dbReference type="STRING" id="91928.A0A0D2BTH1"/>
    <dbReference type="GeneID" id="27334381"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07298"/>
    <dbReference type="HOGENOM" id="CLU_010119_10_0_1"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="35"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="209"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="41920" checksum="96017E303D6A9B9C" modified="2015-04-29" version="1">MATQTITDSTPHSIPKWIQVTETKHELAWADLVTLDLNKFDQEGGKQALAAQLFDAVNRIGFFYITNFGLSQDEVDRQFSLCKQVFELPTDEKLQYRADLENGGYNGYKPLGTREVRPGIRDNTEIYNIPKFTPHYARAHPPVITQHRAEIERFARHIHFEIVRKLLVLFAIVLELPEDFFLANHRYDENSDCHFRYMKYHRRTPEQNAELDNVWVKGHTDFGSLTLLFRQPVAALQIRTPEGEWRYVKPYPESITVNVADALQFLTNGFLKSSIHRVVAPPPDQADIDRHGVLYFVRPEDDTKLVPIESPVLRRLGYDEGPLDQATVGLTAGEWVRARVAKNVSRQGKDEETIIKGVKAKYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BU93</accession>
    <name>A0A0D2BU93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_07634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235065.1">
        <property type="nucleotide sequence ID" value="XM_016381963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BU93"/>
    <dbReference type="STRING" id="91928.A0A0D2BU93"/>
    <dbReference type="GeneID" id="27334717"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07634"/>
    <dbReference type="HOGENOM" id="CLU_009665_14_2_1"/>
    <dbReference type="OrthoDB" id="2096480at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004780">
        <property type="entry name" value="PRK06126.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF21">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW14849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="618" mass="67392" checksum="87193B3E495DB2E7" modified="2015-04-29" version="1">MSSTGGPIHHETPVLVVGAGPAGLIAALQLATNGQKCMLVERNRTTTSWPKMDITNVRSMELLKRLSVDQGLRNVGVPQQYSFDVLFSTSIAEGGKLLAKWDLPSPDEWRRRIREQNDGSMPREPYQRCSQAIFEAWLKPQIEANPLIETHFGWTFKTLEESPDGVRCSVLDLDGQEHVIDAKYVIGCDGAGSKVRAAIGSQLVGGAVPGASYLVHFKSRDLSKLHRQGQFWHIFFTSGATIISQDENDTWTIHVPVPIGTDAKTLDPKEAIFTGLGGELGRLEIEVDEILVTSVWRPNIFLANKYTSDHGRIFISGDAAHQNIPTGGYGMNTAVGDSFDIGWKVAAVLAGYGGEHLLRSYEPERRPVAARNIERSGVHMGLHQEIQTWSSQAPGVITSQTPEGEALRSKVAAKYEAQDGENKDLGLELGYRYTTSPVVVGEDARDEPTWNFRHYVPSTFPGVRAPHVFLKDGETSIFDLFGTGPEYTLVDFTAGGSYGSVFAAAAAEAHVPLKVVRLPDEAHVRRIWERDAVLVRPDDHVAWRAAEGDGVAADPELAKEVLAVAVGQKQSASSLRLKDATAAEVAYAKPSHLNGEAFTGTTGVQKHEEVQSLAAFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXB2</accession>
    <name>A0A0D2BXB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236145.1">
        <property type="nucleotide sequence ID" value="XM_016380318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BXB2"/>
    <dbReference type="STRING" id="91928.A0A0D2BXB2"/>
    <dbReference type="GeneID" id="27333062"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05979"/>
    <dbReference type="HOGENOM" id="CLU_008401_0_0_1"/>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099070">
        <property type="term" value="C:static microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000282">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048492">
        <property type="entry name" value="Stu2_CTS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21042">
        <property type="entry name" value="Stu2_CTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="276"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="505"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="738"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="793"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="853"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="885"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="919" mass="99453" checksum="CB4860E726D359FA" modified="2015-04-29" version="1">MADQEEDYSKLPLPDRFTHKIWKVRKEGYEAAAKAFQLSPDESDPAFRPFLQDPGLWKSAAGDSNVAAQQEGLAALCAFLKYGGQQAAVKSRNYTLQSIYEKGLSSTRPQAKTSALEALLLYIELDKSDPVIEELLPALSHKQPKVIAATLNAITAIFHNYGVKIIEPKPVLKALPKVFGHADKNVRAEAQNLTVELYRWLKEAMKAIFWGELKPVQQQDLEKLFEKVKGEPAPKQERLTRSQQAAQASAPAASGGDFAEDDGGVEEEEVEVDAFDLAEPVDVHSKIPANFHEMIGSTKWKERKEVLDALFDSLNTPRIKEAPFDELIRALAKCMKDANIAVVTVAANCVERLALGLKKGFARYRSSIMSPMMERLKEKKQSVSDALGAALDAVFASTSLSDCLEEILGFLANKNPNVKAETIKFLSRCLRNTRDVPSKAEQKLIADAATKLLTESNEGIRSGGAEILGILMKIIGERAMTPYLDGLDDIRKAKIKEFFDTAEVKAKEKPKAAPAPPKSAPAAGRKPALGAKKPVAKKPATAAAPPAEDSTPLQPKPTAKALPKPGGLARPGLAQPSGLKLGGLKKPGTGSLPSGVASPSRRVISPPMSTDDEDVAAPSPSKFGMGRGGLAGRPLSRPAAAPLSPPSAPPALTGLSAIERAELEELRAEKERLTALNDSLRSSNAKLTAEISELQNQNAQLIEDHTRDVLQIKAKETQLVRARGEVDVLKAEVESVRKESERYKREVSRLGRESIGREREDLMRGRVDEGPNFGIESGGIYEDSTVHRYPANGNVSRPTSSTLQRTGSTASSQSSRAPTSKPRPQSGYTLSPSEEKENGGLDPMAARRKMSPPVNTMANGSGRSSPQRPTFASREASETGSIGSREPRAEENWKRAAEVTSQLKARIEAMKARQGLARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BY40</accession>
    <name>A0A0D2BY40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_06280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236445.1">
        <property type="nucleotide sequence ID" value="XM_016380618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BY40"/>
    <dbReference type="GeneID" id="27333363"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06280"/>
    <dbReference type="HOGENOM" id="CLU_2333620_0_0_1"/>
    <dbReference type="OrthoDB" id="10625692at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="98" mass="11352" checksum="ADE0E520FFD70D28" modified="2015-04-29" version="1">MAAAARVIPPKLSRLPSYNLDKSARKELTYDDWKAAQDLRAMVSPTKFTLWRDHHRHRMSQHEQYKENSKALVPTLQEMLETRLSSACDCHACSTRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BYF6</accession>
    <name>A0A0D2BYF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236570.1">
        <property type="nucleotide sequence ID" value="XM_016380743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BYF6"/>
    <dbReference type="STRING" id="91928.A0A0D2BYF6"/>
    <dbReference type="GeneID" id="27333488"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06405"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF9">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="71"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="223"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="546" mass="60486" checksum="2649C6AC40ECB00E" modified="2015-04-29" version="1">MGWEEIAADKRKRIDESIPKEWRVEVKDQNGSFMDLPASSGLLTADELEITNSSAVDLVSKLAAGKLKSVDVTLAFCKRAALAHQALNLALEFFPDMALAQAKELDKYYEENKKPVGPLHGLPISLKDQLRVKGLETSMGYVAWLGKFDEEDSVLTALLRKAGAVFYIKTSVPQSLMVCETVNNIIGRTLNPRNKNWSCGGSSGGEGANIGFRGGIIGVGTDIGGSIRVPSAFNFLYGIRPSHGRMPYAKMANSMEGQETVHSVVGPLAHSVPDLKLFVTSVLQEEPWKYDSKVIPMPWRQAEEDIIHTKISSGGLTLGFYNCDGNVLPHPPILRGVDMVVSALKNKGHTVVPWKPYKHDFGVDLINKIYASDGGFDIFSDLKKSGEPAIPNFQDLINPSLPKIDMNEAWDVQRQKWAYQSEYLEQWRLREVELGREIDAFIAPITPTAAIRHNQFKYYGYASAINLLDWTSVVVPVTFADKEKDKKLTDFEPLSDIDRIVQAEYDPEAYHGAPVAVQIVGRRLSEERTLAIAQEIGKLLGNEITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C232</accession>
    <name>A0A0D2C232_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_04909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237930.1">
        <property type="nucleotide sequence ID" value="XM_016379253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C232"/>
    <dbReference type="STRING" id="91928.A0A0D2C232"/>
    <dbReference type="GeneID" id="27331992"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04909"/>
    <dbReference type="HOGENOM" id="CLU_015365_0_0_1"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="698" mass="78473" checksum="5ECEBE05FDD793CF" modified="2015-04-29" version="1">MHDDKRGESSKRPPPRLPVIAPKDDRSSSASSSRSGQLGPTIPPRARLPPRSRTGCWTCRTRKVKCDERRPECGQCSRLGHTCDYSPRLSFRDDTPRVRERMQDITVVTNTIWDSNSPARTDTSAGSVPVDDLPPFAALMTDEEREKKAEHSSPGTYNVVVNQDSFQHLPEYNDESAIKREPAVPLRRASIAATHVSLSGRDIAVEGVPLAGDPNVVVLPRFEDIARRNTFSSSKDLHSQLSPLAKQRFIKEEESDEIAIVDEPMSIMEDGFDSEGQRYSRQFRYVVWKQLVPAELDQMDGMERSSVELLETAARVFPPLRHAMMALAALSLASTESNSRLDALQHYQQALPALQSVLRGPDDLSSDGAFLTHFLLLVYEIAAAEADSSRLWSQHLSTLLRIALLRRDVFGGERYPFVIWWICNIDLDALFSGAGGGEFVGYMLQHDSIPGPSFHLHPLGMDGSSIVYSGELESLPTILQLDYEVTILAVRLAMLAHEFRHDTTFASADYLHRVQAVQIRQSRIYELQESLRQLWLNPAVAMIGQIGNGLPERSIRLYEHAAALYRACILFSHTSMWPGQRLDTSPDYDTEIAVASNQILQMTMKAHAEDRYHCRYLVFPVFMAGYCSTDGGQRMQALDLIRAMEKNSIGRNTSVTRRALATVYEKQNERFMNTGQSLDVDWMQVMTEKELLVINFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C4U5</accession>
    <name>A0A0D2C4U5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238820.1">
        <property type="nucleotide sequence ID" value="XM_016377250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C4U5"/>
    <dbReference type="GeneID" id="27329976"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02893"/>
    <dbReference type="HOGENOM" id="CLU_436159_0_0_1"/>
    <dbReference type="OrthoDB" id="4157239at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="774" mass="84630" checksum="9D6881376C1CDAA5" modified="2015-04-29" version="1">MGRGGKNSRARRSARATQQFFSQGLPDGSALSSVEGESSSTNIPPPAPPSSPIQSRSENTRPKASPETESLPKEYTSLVPSPFPASKLRFITDHLWQPAEKTLIPFFRENETTGIKYLYSQIAYLYAFKLPDQKKLSWQFDPEITRGLAEDVVKTPALDKWFKTNGAVSTGLKVEDIVITTQPGINEYQAILLICQWLVRRAVVHGDRSNIVSASPTILIGLIDFTYRTKHAARSSSADPQFKAVWDWFHNDRTARMGNKQNVMVPDALDYPHVHESDHEGGAAEGEIIETHFRDCFEYLMDDSSDDGSDPGEGPSTTHHTTSSPLDKGKGKAVERCPTTSSTQTHVAGTVTKSVGHVDDVLTTTTSTTTTGDKKKKKRRDNHKRKDKKKKNNPNKKNKKNKKNNKKGKGKAKATDLDEDEAEHEQEQEQDAASVDDDTANVHTSDDEVSLPYYSAKEGDDREENSDDDEDEDERVEEQEMILHENFDTGDDQVNDQEVPAVDDDGEEAYDAGDEVDDDDDDDGDDEVTQKVNDHGKGRAIDQNEQQEDGDGGHDNDNDEFWTEEDQREFDAWFDAKFQAPWDRIMSRLASLPSPSSVVGNTTATNDNVVVGDNNVVVGGPSSTTAASRRRRAAPLEGIDAGLDRSRPASSVAANENLQRHLLAVLERARAGGMSRGARRALLAREHQRILASETLAAARGTQPLRPTATRATEAAAAETRRELARFPRFNLGSAPGWLGELERMQIGGLRGGRGGGGGVGGAGAGAGVGGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6V9</accession>
    <name>A0A0D2C6V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239530.1">
        <property type="nucleotide sequence ID" value="XM_016377960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6V9"/>
    <dbReference type="GeneID" id="27330691"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03608"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="78"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="522" mass="56836" checksum="E2A0F07FA698D3AD" modified="2015-04-29" version="1">MAPPPTSGPLPENTGGHTMELDKGKATGVTEDAASCQEGQLELQAMAARPRPATLDRFNDAELGLLSQKLVRKIDLFILPTIGILYILNYIDRQNLAAAKLQGITKDLNMTTEQFATSISILFVGYLPFQIPSNLLITKISRPGMYICVAVVIWGSISAATAAVNSYGQLLAVRVILGVVEAVFFPGAIYFLSAWYTKRELGKRIAGLYIAQQVGNAFGGLFAAGIGKLDGTHGIAGWRWLFIIEGSATVGIGVICACLMPEFPHNSRILSQPERDLAVWRIESEAGAAEGTEKESVARGFAKALSDPKLLLLIFCNMLSQAQGSIANYFPTLINSLGYGSTDSLLLTAPPYVLAGFVYYGITFWSDRKNTVYPIILCCISIAVCMYIIPMATTNVGARYFSMMLLPFSSVGPQILLYKTINLHLARPISKRAAASALVNAIGGTSNIWASYLYYSAPHFYAAFATLMGCAFVFAATLTFYRYLILRENKRLDSGNPQQIAKAMKGGVTQEMVDLGWRYEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C7A5</accession>
    <name>A0A0D2C7A5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239655.1">
        <property type="nucleotide sequence ID" value="XM_016374379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C7A5"/>
    <dbReference type="STRING" id="91928.A0A0D2C7A5"/>
    <dbReference type="GeneID" id="27327094"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00011"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_11_1"/>
    <dbReference type="OrthoDB" id="4109642at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27238" checksum="CE079F5D03A29BAB" modified="2015-04-29" version="1">MADQVVIVTGAGNGIGLSMIQLLMKSAKVSHVVAVDLNIDKLKAIQKEHPEKVSLVTGDVSKTSTSIEAVETAVKQGGHLNSLILNAAMVRPTGYLPKLVVNDWRKAFDVNFFSQLDMMQQAWPHLLESEGNVMMTSTRVSQEPTDSWTCYATTKAALNYLCSCLPLEEPKIKYVAITPGAVDTDSQTASRLDGKIKNFSPKMRKFLNEIYSSNKLLKPEQPASAFVKLVETGIPDKFTGKTIYWGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C7L6</accession>
    <name>A0A0D2C7L6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239735.1">
        <property type="nucleotide sequence ID" value="XM_016374459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C7L6"/>
    <dbReference type="STRING" id="91928.A0A0D2C7L6"/>
    <dbReference type="GeneID" id="27327174"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00091"/>
    <dbReference type="HOGENOM" id="CLU_031138_1_0_1"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="502" mass="53487" checksum="2E0B7E741170E287" modified="2015-04-29" version="1">MASLFTARRKPKRIVRDEPEAQADDVEEDTGPVVRRPTGNAPRTKSKLRMSFNPGGEEDEASQRGTTATGGGGGSSGGDEAARSTRPPRLGLSSAAHSLLLNRSEGQDRHDDRARNLKEGDSNSSRPTYSKAYLDELRNSTPSTPRDLSSARASPSLDLVDPSASNTAAALDLESKFGKTTLLSSSSSYIPSAAEIREKKERRARLAKEQAANAGSGDNAGTGAAGADFISLEDYDSDGEFKPRRMQVGMYSAAAAAREKDTRLVHDDEDMAEGFDEFVDDPGRVTLSRKGQREQTLREREAMRALIDEAEGASDDDSAAGGGEEAGGQDLSDSDSDYERHAHYETAQTHRGMDGLGAAHAAHTRQANRPRQPRDTTAIPKLSAGLARLRDMVSRLEFETARIHKRRADIARERSEIKLSQDHIQTSLEEAGKELERVTREHLGSGPGPGSGPGTGHAQGPDRAQQTTTASTDTTTAAAAATHNGSLSTAERGLETLGGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C961</accession>
    <name>A0A0D2C961_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 10">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_00669</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 10"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240310.1">
        <property type="nucleotide sequence ID" value="XM_016375034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C961"/>
    <dbReference type="STRING" id="91928.A0A0D2C961"/>
    <dbReference type="GeneID" id="27327752"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00669"/>
    <dbReference type="HOGENOM" id="CLU_013325_13_1_1"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="11">
        <location>
            <begin position="352"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW20094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="436" mass="48052" checksum="19B6FBAB7F2BB9B6" modified="2015-04-29" version="1">MAVPISSLLTNGAPTTARDRWTYLDNVLSTTSPYAGEEFVPGNETVNALETSRVLVIGAGGLGCEILKNLALSGFKDIHVIDMDTIDVSNLNRQFLFRQSDVGKSKAEVAASFVERRVPGVKITPYNGKIQDKDEEYYMQFKLVICGLDSIEARRWINATLVDMVDMENPESLKPLIDGGTEGFKGQARVILPSLTSCIECQLSMHAPRAAVPLCTLATIPRQPQHCIEWAHIIAWEEQRKGESLDTDDPEHISWLYQTALARANEFNIPGVTYSMTQGVVKNIIPAIASTNAIIAAACCNEALKIATSCAPFLENYMMYTGDSNDAGLYTYTFAAEKKDDCPVCGNIAQNMTVDPEITLEEFLASLAERAEAQLKKPSLRTEAKTLYVQAPKSLEEQTRPNLEKKMKELVSDGEEVGVSDLAFQISFKFKLVFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C9B4</accession>
    <name>A0A0D2C9B4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240390.1">
        <property type="nucleotide sequence ID" value="XM_016375114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C9B4"/>
    <dbReference type="GeneID" id="27327832"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00749"/>
    <dbReference type="HOGENOM" id="CLU_553209_0_0_1"/>
    <dbReference type="OrthoDB" id="3641178at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="402" mass="45459" checksum="5BA2F3387BAE16FA" modified="2015-04-29" version="1">MGQIAHDFSNSKPQLLDSAQECFKAALSCLPVPYASAEGGSYDQLEITPSVVSDSPTSSKLRSPYVSPSPSVVESLSAQSKLINGLSYRIPSALACESARSLSISLQTTPTFQREDEKEKEKESGHGDFAAPKTPIGHKHRLCQSLSFTHSLQDDLVPSPLFNRNQKRAQIYSSRPELSRRPLPPLPFGHSTTFAVEGSRVVQVPQWGMRKSAVQTLIAKYEDTTPLTQTPSPRRITQNNTSVCSPVTPRFRRIRDAFSPDPRNDSLEAYLSSADLTRYSLGISDFRTQLRKHISSLEVEVRRVRDLQAQRMARKAQRKHRHTSFWTFQPANRLVPTLIPSDTEKKGGLDDPVTAARKERIERLRREGWNVRKEKYGFKGVEWYEAFRCRVEKEIAEYERAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCX3</accession>
    <name>A0A0D2CCX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit Rpc5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241570.1">
        <property type="nucleotide sequence ID" value="XM_016376294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCX3"/>
    <dbReference type="STRING" id="91928.A0A0D2CCX3"/>
    <dbReference type="GeneID" id="27329017"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01934"/>
    <dbReference type="HOGENOM" id="CLU_045565_1_0_1"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="45630" checksum="E6BC828F3B934C41" modified="2015-04-29" version="1">MDDEDDPVVASYDVLLTDPAKKDSSKLFILQYPAHRRRDRPYNATYGQTPTSLRLKPDTGFVEVDIPLRITEHYNADAARKFGKAMYESRTMSAGGSHGLGGGFSTGPSDPRMRDAPMHDHNAFDSGILTTQTLGGKVVTPSSRDPIYLVGSFHENQLHLTHVDAVVQMRPQLHHIDADDELAQKKLQSNASIARQKPGLETPAAKVESKPIEVKIKNDKEDAKDRSLNENARLLRDIQVDKWEKHDWVGEEDDEAATKFDQYLHSHTYSRESLVELKSSLTNGKWLDNMSAPREEGRKGLLGKVRGRERERARRRKAEEEKRQRQREAPGSTRGQSGAMLDMSSESDLTTPEASESEVEDETAEARTQEIDTIAIKEEPSVSTASMATSSSTPKKRGRPRKAQNAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y4U4</accession>
    <name>A0A0D1Y4U4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11722</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230162.1">
        <property type="nucleotide sequence ID" value="XM_016386030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y4U4"/>
    <dbReference type="STRING" id="91928.A0A0D1Y4U4"/>
    <dbReference type="GeneID" id="27338805"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11722"/>
    <dbReference type="HOGENOM" id="CLU_030575_0_0_1"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02110">
        <property type="entry name" value="SO_family_Moco_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF6">
        <property type="entry name" value="SULFITE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="195"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="402"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW09946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="65891" checksum="A7C0335FE2342E57" modified="2015-04-29" version="1">MAPAHPKSTFIRPLPGEALPIHNRPDEWKIEQGLSGGKLPILDQSGPETRIIPPQKWPDIIKDEEAIKAVGDPNKLFTRELEGWKGYVEWEEFPEKKEKARRILAAQNFPPNPEFQMGPIPDSNPVLPGTHWKMWHHAVGGELMDVPEDSWATVLREKHPEMLHLLQFPYNGEPPKRLVTDKAVTPNSLHFVRNHGGIPLIDKDKFFFTLDGLVANPRSFTLDDIMDESKFPRIKKLVTMQCSGTRRIEQISLYAGQGDEVPQAPWAEGAIGTAEYVGISLKKVIKACGGLLEGAKHIEFYGAETYFKDNDVMNYVVSVPWSKVKANEVLLCWEMNGEPLPAIHGFPLRVMVLGYIGARSVKWLYRIKAIENPSLAPVQSKEYLYFNQQVGKYNQKPTDGIQIQEMPVSSAIMSPWTKQVVIHNGKIHCKGWAYSGGGRWPERIELSADGGFSWYAVPNTNLSEKHKWTWRTWQFDLPCDVEGWVEIVCRCWDNSLNTQPLTVRAAWNWGLHVTSSAHRISVYSVNKSHARTREKLQQFVDMNSPIAPLTWPEEFPTQSWEEYKQFWKENDPRDVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y5K6</accession>
    <name>A0A0D1Y5K6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_11172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230427.1">
        <property type="nucleotide sequence ID" value="XM_016385483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y5K6"/>
    <dbReference type="STRING" id="91928.A0A0D1Y5K6"/>
    <dbReference type="GeneID" id="27338255"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11172"/>
    <dbReference type="HOGENOM" id="CLU_004544_4_3_1"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="257"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="543"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="847"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW10211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="900" mass="101209" checksum="79ABD30C965C627C" modified="2015-04-29" version="1">MSDRKSVPYVPYFRNVTAPGTDYEKKYALPTEFTKRPGYNNTGKAIQLAVNAYQVAQYPTAKVYQYDVTIGNGTEKRAVQRKVWNSKARKNATGPPMLYDGNRLAWSLRDHSEIRLMVDLDVEEGRPTRDGRNTFRLHIKKTREVDISLIQQYLHGRVQFGQDVAECINFMDHLLREGPNSNPQFLTIRRSLFKRQGQRADLGGSVEVWRGVYQSMRLAEGQKLIINLDVANTCFWRPGGLLATIITRWGMQNPSVVTAKLAPRGNGTPEESLDHITVRKGIKGVMVIAQYKGNPFPNKEWKIHTLSMHNAHQEQLDWKDPVTKQPTGEKLTVAQYFQRKYNVALQYPNLPLVEMTKKGVKYPMELLQVLPGSRYNVKLDEVQTANMIKFAVSPPHTRLQAINEGKAWLDWAGDSYLKNYGLRINPEPIKTNARVLPAPGVKFANKTQQPGTKGRWDLRGCRFLNRNPQELVSWGIGFFPGRFKPDKPALEKFALDFTRAYRDHGGQVANQPPVIMPLKADVGEAVNGLYQATGNKFQRRPQLLIFLLQDKQAFHYLRIKKSMDCRFGIVSQCMQIQQVLKGNPQYYSNVLMKVNAKLGGSTAQSVSHPTSGFKGFNKPTMIIGADVSHASPGSEQASMAAITVSFDRFAGRYAAACQTNGRRVEMITENNWRSMLKPLVREWMSQVGGGAIPSQVYYIRDGVSEGQFIQVLRTEVPHIKAVLTECNNNKDWTGTLTVVIAGKRHHVRAFPGKDASDPKGNPLPGCLIERDVTSPNEFDFYLYSHIALQGTSRPTHYSVIYDDANHSPNALQNMIYEHCYQYMRSTTSVSLHPAAYYAHLASNRAKAHEDVPAHRGPQGGAGYKMKTPSGSSQPSDTEVAPLLPLFTGAGSSILWSMWYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y5V5</accession>
    <name>A0A0D1Y5V5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_11253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230507.1">
        <property type="nucleotide sequence ID" value="XM_016385563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y5V5"/>
    <dbReference type="STRING" id="91928.A0A0D1Y5V5"/>
    <dbReference type="GeneID" id="27338336"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11253"/>
    <dbReference type="HOGENOM" id="CLU_412211_0_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="477"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW10291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="666" mass="73934" checksum="3B2D398055DD6A79" modified="2015-04-29" version="1">MSTAGGRGDALAVLEKDVPYDTGALGGNLANPGTWRGVTLSPPGTVFCDGSFPGLQLGSFVKAAVDRQHEQEALAGQLDVEVKRIKRIVRRLDSRLVLILAVLYVWAFIDRGKPANFFVGYILIDAPATFIVRKIGALVWLPTIVVCSCNAKDWKVWEFSFHGLFNNTALYAFAYFLPVILQKSLHYPTSKAQLFTFPPYAVAAQWILFCAWICDRLKVRGLMLVLNSSLYMIGVCITAFCENPHARYGGVFIGVMGITGNASNPWAYAHNNVGKLVANQIGGSNSDSRLVGQAERALCAVIIAGNIFQAKDAPAYRTALIIYIAFQSFNILLVVNNSVDFARAHKKDKQRGVDHRRNARFLDLAFTSDLPQEAFNDNAHIHHDSRGPIGRVEPETSFSRFGSPLPALHFETREQASRGSGQAELNANCRPVWKISGHHYRQIVTNIQKFDQVMPKGFSMPSRHTMFRFLEGAIKGYYEHLPNLHVLTFSPVQATPELILSMCAIGVLFRFEAHRCPMMFHAAKAIAFEQIKIQEQARLAARASLQPQIPLSMSLGLNNTQRPSELKLADIGDKVMDPDVQTLQALIALLCLGAWGSQPELVKEAIALQSVAAPMVRGDGFSRLRVTSSPCAGMSEWHRWVLQESRKRTKLMTYCNWSPLPTTYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YBJ1</accession>
    <name>A0A0D1YBJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232522.1">
        <property type="nucleotide sequence ID" value="XM_016383899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YBJ1"/>
    <dbReference type="GeneID" id="27336666"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09583"/>
    <dbReference type="HOGENOM" id="CLU_085773_0_0_1"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257:SF1">
        <property type="entry name" value="DUF1330 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002236841" evidence="2">
        <location>
            <begin position="19"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="300" mass="31452" checksum="6F50524658A2010A" modified="2015-04-29" version="1">MPLATLHLISLAPTATISSFVGSLKSTAVQPLTISKVIRWIITPTKIEADTLLRPSRPWDVLLIVLGSDALPETLASQIACHWSAVAGIPSRLTKDFASTNDGVLHPPPSSVPPLTGALDTPRLGASSQTLEMSSELLGWIRSFKDTKAGSSPLSMLNLLAFKPGLKDSYLQYGKAFAESIGSRRGGNAKLVGNIVSSAGSSSSSSSSSSSTAAAATTTKTTTTTTTTTKGAGHQKGWDEFALASYPSILHFADMLASEDYQAVNLKYRVPALEDTLILCTSEIEIETVTARGGKGASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YFR4</accession>
    <name>A0A0D1YFR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234107.1">
        <property type="nucleotide sequence ID" value="XM_016381005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YFR4"/>
    <dbReference type="STRING" id="91928.A0A0D1YFR4"/>
    <dbReference type="GeneID" id="27333755"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06672"/>
    <dbReference type="HOGENOM" id="CLU_015634_1_0_1"/>
    <dbReference type="OrthoDB" id="5359231at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="89579" checksum="6C2EEF7730104AD8" modified="2015-04-29" version="1">MSSLSQFPFDILYQVAGQLDVVSYDSLSKASRSLHDCLRDEHTARISVHASVLFSPWSQLALSANKGSFRTTIDRVSLCNNAFQTASPYSASVLGHATSFSYHGGIVCYTTSSHLRILDFNHRPTSEKVFAHAFFRNFLASSKQGAVKVELETFRTLQLKGCADNVAILTCHLGIYGLHLFAVNISEDFYESSPGTTNIRRSRIVLSTPLISNKKLFVRHNSRYIIWGTHSAAGNEGHHEWLLYRHDLATPNVVSKEPLQLSGFSGGEVGSTACFTIFEDHFYAVTNQASFETEEVDWTSYYHVVKFRLDSENPDVVPRMVWRRQHLEGPINDAWTDLGFQIDHRTGELLIVECRKEWVDGGSRCVRTYYSQPMKRAVLLDAEAIPRAPPDDPLRRTLDEKNNSHYEDSHVRIERYMHSEYAKYGAGEDARDRKKEYIRAKTKWNGYDFNRQCFVDLVSDDVTDEGSWRPRERLRLRIVSRKEISPLVLDQEAYVHGTENEDLTTGQRQNGDLKYRVRPRVKGKDGVALTDGEEKFTSSEIVLWPSDAMEVPRGLDDVLCPGGKAGDVTAVLGYEGIVYLAGPADWTKGGERALVFVCFDPTFGFDGMKRVDGSVAVPRARGGDDVAGGREQEARGSKERDKKKRRTSESVVSSAAILDGDTGGDVKERMTAHGLVQRTNKRIKSEEGGTVHETEAEVATAHKTTVTEADADAGLRRSDLSPYQSAPRVTTTTTTAAATCPTPLGGLGAGPSSTTSAPSARTPDASRDDKASVNSVKTTKPKVSSTAGRSTWREKAAHVSIGKGFWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YGK7</accession>
    <name>A0A0D1YGK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234347.1">
        <property type="nucleotide sequence ID" value="XM_016381245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YGK7"/>
    <dbReference type="STRING" id="91928.A0A0D1YGK7"/>
    <dbReference type="GeneID" id="27333995"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06912"/>
    <dbReference type="HOGENOM" id="CLU_046574_1_0_1"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="16"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="372" mass="41501" checksum="E4373D574608AA79" modified="2015-04-29" version="1">MSSVIVQPINASDPGLGALVQNIDPAHMSEEDFTVLHNALYTHNVLCIKSQGKLTPKDQAELTRRFDPAALSYGHGRTIDAKRSVLHPDLKTIPHQPEVQVIGNGFVPEYEGLKNITLRHPHHRTFHKTVIPNAQDLDYTRFYRWHIDAALYGQLNPPLVTSLLAVKVPGGRRQTVLYDDGTDDVLDVPLGTTAFVSGYKMFDNLTLEQKDFALTSKVEYAPHPYVWISTTKSRSDGLGMVSEGKEVPIDELPPIENETDTQILPMVWKNPVTGRFALQIHPSVVRKIHLKDGTVIDDLAKVREIVHSMQRPAIAPKYVYAHDWEEGDLVLFNNHGVLHTVVGAFAEDEVRLFRQCNLAASRPPLGPIISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YHA6</accession>
    <name>A0A0D1YHA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234547.1">
        <property type="nucleotide sequence ID" value="XM_016381445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YHA6"/>
    <dbReference type="GeneID" id="27334196"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07113"/>
    <dbReference type="HOGENOM" id="CLU_1315263_0_0_1"/>
    <dbReference type="OrthoDB" id="4143071at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="211" mass="23994" checksum="49D6C2270F082631" modified="2015-04-29" version="1">MAKTIDNACADEPSALPFKTGGPLARNQEYLIFYFLTVSSWGLQIASACLGSLYGAQSHYFIATVSPFFATHWMAFLQTCWLMATAPRNTVADRVSYLNLACRFQRLCAPTALIGMITWAVGYRFRGKASSQAYWIIWLVVWIMETVICIMNVYNNINWESDLLYQIAPDYPQGNYWLGILGIRSICRTKYRNPKDDGFEMTDGATLREEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YI81</accession>
    <name>A0A0D1YI81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234862.1">
        <property type="nucleotide sequence ID" value="XM_016381760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YI81"/>
    <dbReference type="STRING" id="91928.A0A0D1YI81"/>
    <dbReference type="GeneID" id="27334513"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07430"/>
    <dbReference type="HOGENOM" id="CLU_033575_0_1_1"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="43716" checksum="871A0711464DF34A" modified="2015-04-29" version="1">MAAISYSADPTLYLYTSLTAGSSHIITATSRLETILKANKIPFRAVDCATDEKARMLWGRRSKGRKLPGLVKFGTIVGDLEQIEEWNEYGELQDQIAGFSEFGGPVPTPAPAPTPATLAPEPTTRSANSSGPPSRASSETRHISIAEPKGKDSAASEGAASKPAETPLNIAMRQLGAEAAAKAGQKKAAALQAAKVPTKTPDTTEKIPVPATTKLSVDAAAEDPETVGEVTAAKTPALLAAEGAKRTSIDKIAESEGGASSTSSSDAEGHSTEAQIVEQRRKSSITKLKSRLSESTPADQAETVVVDSSPAPKSETAVPESEVSADPPVETPKQHRGSDIGEASVEEIKEIEKETSIPEAAEEEKDKSGAVATSTNSTEKEKEQVVTSTDETEEQVTKGTDPQDSRAKDADKAGVSVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKP0</accession>
    <name>A0A0D1YKP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235762.1">
        <property type="nucleotide sequence ID" value="XM_016379935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKP0"/>
    <dbReference type="STRING" id="91928.A0A0D1YKP0"/>
    <dbReference type="GeneID" id="27332677"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05594"/>
    <dbReference type="HOGENOM" id="CLU_120565_0_0_1"/>
    <dbReference type="OrthoDB" id="2819018at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046580">
        <property type="entry name" value="DUF6640"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20345">
        <property type="entry name" value="DUF6640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="179" mass="19699" checksum="FADA827516FE96F8" modified="2015-04-29" version="1">MPAPITPGRVCLSLVAGVLGPGCFVADWSRTHVFNPRWPPHAKFHNGQTMAMGASLALGTLYYTWRVPGRHLHLHLKAGREGALLRDNDDGSTTDTDVDTKRELEKESIRIATLLGSLYFVTALAAWFFPGSLAVDPEFGTGFPQFPMFSGLLILAWVGGWLELTRLEGLDTKHGKKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNW6</accession>
    <name>A0A0D1YNW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237037.1">
        <property type="nucleotide sequence ID" value="XM_016378360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNW6"/>
    <dbReference type="STRING" id="91928.A0A0D1YNW6"/>
    <dbReference type="GeneID" id="27331094"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04011"/>
    <dbReference type="HOGENOM" id="CLU_008523_12_3_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="472" mass="53165" checksum="D5C019294F5A90CF" modified="2015-04-29" version="1">MNVSEFFVESLPDVPQSFMTELYSGIIPLNMSDDSRGMFFIFQPRVGPPVKEITIWFNGGPGCSSLEGFLQENGRIQWSWGQYSPTINPYSWVNLTNMLWVEYPIGVGFSPGEPTATDEEEPALEFVEFFKNFQTIFGISNYSIYVTGESYAGRYVPYVANAMLDQNDTTHFNVSGALVYDPCIGSWPTGNAVSVYPWIEKYNNIMGFNDSYVSMLADMDKKCGYAQYRQDYMHFPPNGTQPITYLNTTADPDCDLWDSVYYTAYSVNPCFNVYEPNLQCPLLSDPLGFPTDLIYSYPGLPPYFNRTDVKKAMHAPVDVDWELCTGPVFVAEDGGPEDENDLSADPIQKVLPRVIEATNRVLVSNGDLDLEVLTNGTLLAIQNMTWNGNLGFQAEPSKPISIHIPDIQYQEVFVSSGFEGVDGPSQGIMGIQHYERGLMWAQTYLSGHMQPQFQPRSTYRHLQWVLGRIDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPQ1</accession>
    <name>A0A0D1YPQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237407.1">
        <property type="nucleotide sequence ID" value="XM_016378730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPQ1"/>
    <dbReference type="STRING" id="91928.A0A0D1YPQ1"/>
    <dbReference type="GeneID" id="27331465"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04382"/>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35311" checksum="1BB96306373E9883" modified="2015-04-29" version="1">MSNNCTELSVECPAELSVYGYLPSVPANAFFLGFFALFGLLNLGLGIRYKTWSYMVALCLGCLTEAIGYVGRIIMHSNPFADSGFITQICCLIIAPAFNSAAIYLTLKHVALCFGPQYSFIKPRFYTYIFICADFLSLLLQAIGGAMASTADTQDQQDLGDNLMMAGIAWQVAALTFFAVTAIVYVLRVKRGMRHTPLSAEAAATLKDTKFRLFALGVVTAWFTIFIRCVYRIVEMAGGWRNDIMQNETGFIVLEGVMIVIATACQTIFHPGFCFPRLSSKWSSEWSQVPTTKTSQDVSMEDLRPGNTAYRSPGYDGSANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YR94</accession>
    <name>A0A0D1YR94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_04971</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237992.1">
        <property type="nucleotide sequence ID" value="XM_016379315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YR94"/>
    <dbReference type="GeneID" id="27332054"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04971"/>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="84"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW17776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="523" mass="58788" checksum="DA8C3BEF70346C30" modified="2015-04-29" version="1">MSKATADLGPGPVPGLESKGSLETTVVADKDSNTDSVPSQDERLVDVPKSKARRVLRTIQRYTWDDPDRPKHEKWFIFKLDVFLLSIACLGYFSKNLDQSNINNAYVSGMKESLHMEGNELTYAGNVFTAGYVVSQLPAVILASKVRPSYFIPVMEILWSVFTFCSSAVKTPSQLYAMRFLIALCEGTYFPTMVYIIGSWYTKRERGKRMTIFYSTASLAGMFSGYLQAGAYKGLDGRLGHQGWQWLYIICGIISLPIGVMAFFFIPDFPETTRAFYITKDEAAWARERLVADGMKPLGAAAWNRTKIFKIMAQWQFWVLPVGYFLVQASFPIYQPVYALWLKATHHTIYQINVWPTGQYAVAVVVQIAAGIITDSPLLRGKRWQAIIAMQTPTVFACIVLAVWDVSEGLRFAAYYLSYSAAGVPGIYYAWYSDLIPHDHEMRGFLIACSNMFSYIQSIWWTDTVWRTTLGPRFHAAFIGAASIGVALMVLSILLRILEKRDGKIREKRALAEVGVVEGQISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSM9</accession>
    <name>A0A0D1YSM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238492.1">
        <property type="nucleotide sequence ID" value="XM_016376922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YSM9"/>
    <dbReference type="STRING" id="91928.A0A0D1YSM9"/>
    <dbReference type="GeneID" id="27329647"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02564"/>
    <dbReference type="HOGENOM" id="CLU_000134_20_0_1"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188:SF29">
        <property type="entry name" value="GH09064P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="225" mass="23017" checksum="12F54B9AC26CF664" modified="2015-04-29" version="1">MPSANAAAPPLPTPTPDELDDLIYFSRVGDLDSLKEVVTNLCATHSCPPSVIVASAIDVDEDGLGSQSSLLHYPAANGNLEIVKYILGLLTPSDALGSSVGATTADKSAPSLVNHKNVNGNTPLHWAGMNGHLEVVKALVGAGADPGIANAAGRDAVFESEISAKEGASECAEWMLKECEGLEKGVGVGHEEGEAAQEDVDSMGQEEASTSENGTAHTATAEKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YV04</accession>
    <name>A0A0D1YV04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239322.1">
        <property type="nucleotide sequence ID" value="XM_016377752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YV04"/>
    <dbReference type="STRING" id="91928.A0A0D1YV04"/>
    <dbReference type="GeneID" id="27330481"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03398"/>
    <dbReference type="HOGENOM" id="CLU_721678_0_0_1"/>
    <dbReference type="OrthoDB" id="4356615at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="402" mass="42728" checksum="614461F447730ECC" modified="2015-04-29" version="1">MDGDEAPAHGDSNDNTDHNNNNNNPGKASKRDRFKGALSRTKSKFKKHDNKSEAEINDEVNDFLAGGRTSTSSWTSGKDTLRPGTITTTQGYSSSLETSPADQAASPRPSTSDSASISRHSPRKITVPKIDVSNSQRWPAAQPLSPQGPAEGAAGFLRPEYHGRSQSASSLTKRKGRARGLSVTFIDDPPTVIGEGGDDAPTPPLEISKAKARARSVSPMSPRVRQRPAGASRPTAAGGAGAYEYPRPPAAPASSPSSQHEPPDVLRPRGLQRVQTGLSPSAATASLGLDKEFEMTLQIGNQANPPGREVASNSPEIIAPRPVRPVQPPPLVVERPDTSVSVVHEAQSSSSSSSGRADDFREGDVLRMHHDPNIPTIEENTPASGSSREVSPVKQRQYQNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YV53</accession>
    <name>A0A0D1YV53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239387.1">
        <property type="nucleotide sequence ID" value="XM_016377817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YV53"/>
    <dbReference type="GeneID" id="27330547"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03464"/>
    <dbReference type="HOGENOM" id="CLU_1713284_0_0_1"/>
    <dbReference type="OrthoDB" id="4161609at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="158" mass="18021" checksum="111F330854E80FC4" modified="2015-04-29" version="1">MAASFGYSRLDPILYDLSHAAGARQFQKMAREFMAVVRITPDMDAEHLVNFSKIVDNADGWALASNVVPEFRLPQDTDTDENTALHLILRTMRHKRPRVNMYDGSSRAEEAEKELLRKEHRAIIDYVETCGLGIERATPEEVAAANELYERVVNMLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YY86</accession>
    <name>A0A0D1YY86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240467.1">
        <property type="nucleotide sequence ID" value="XM_016375191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YY86"/>
    <dbReference type="STRING" id="91928.A0A0D1YY86"/>
    <dbReference type="GeneID" id="27327909"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00826"/>
    <dbReference type="HOGENOM" id="CLU_024840_0_0_1"/>
    <dbReference type="OrthoDB" id="5595109at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="576" mass="62732" checksum="B2944BC6965EFBB5" modified="2015-04-29" version="1">MRHGASRLPRVLRLNKPLTTIHPAPPRHVPLERPGPSAHTLSAQRWSSSASESKPEPVGHEDHLPTPQPPEANPAASPTLSVRQWSTPLAKTIAQAIEVTGPVSIASYMRQCLTNPDGGYYTSTREDADQFGTAGDFITSPEISQMFGELVGIWFMTEWMAQGRPLQGVQFIEMGPGRGTLMSDILRTIGQFSTFAKSVSAVWLVEAGEGLRIKQKDVLCGQDAEMKEVRDRTGKNVWWEATSKQGIPVRWVEDVVLLPDQTETDDQTIPFIIAHEFFDALPIHAFESVAPKPEEEQEAQSRLLSEAGQPVPKPSTASKLPQWRELLVAPTKPKFDLSSSQATSGADAPTPARKTQPEPDFQLTLAKASTPSSLVIPERPRYRHLKNQVSSRVEVSPESSRYVQEFARRIGGAAAADARSKGGKPSGAALIIDYGPLETVPVDSLRAIRKHKIVSPFVYAGEADISADVDFVALAHAALEASPGVEVHGPVEQGFWLGQLGIKHRAEKLIAELGKTTKGELPPDELERKKFELETGWKRLVEAGPKGMGKAYKVMTIVPENGGRRRPVGFGGGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0J4</accession>
    <name>A0A0D1Z0J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241342.1">
        <property type="nucleotide sequence ID" value="XM_016376066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0J4"/>
    <dbReference type="GeneID" id="27328789"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01706"/>
    <dbReference type="HOGENOM" id="CLU_066669_0_0_1"/>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="316" mass="34431" checksum="7DFCE335589E123C" modified="2015-04-29" version="1">MPATTRSKSKQSHLEDLGVKEPKSKNAKDKQQLPQSKTSRSKAPDSKKRTSSPSPSESKSRSKKRKSSSSSTTSAASSSSPPSSKKSRQGQRGDKSSGSSPDTARNKNNNTAKDEDTGNDKDKEEDTIPINRSPVLQLWSACVAHHLYPQFPWTTDLAIGAAISTLCAIAKGKSIGTIEPREKTHDEEAEQSAERRAAEAGADREIQVMGFRLYVKGEDVLVQGKPRRGNEDLLKRKFGPGNYERAKKAMDDAIATWTTTATTGGGGQGGKRNDDELNSKAFHMYEEFRPSVQSGQSGWGKKGVLKLNRVREVVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZB61</accession>
    <name>A0A0D1ZB61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230478.1">
        <property type="nucleotide sequence ID" value="XM_016385534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZB61"/>
    <dbReference type="STRING" id="91928.A0A0D1ZB61"/>
    <dbReference type="GeneID" id="27338307"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11224"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF804">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="204"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="349" mass="39751" checksum="A8BCCA0885FAC1D5" modified="2015-04-29" version="1">MSVVETQTEAQSPLVIRLQNGQTLHVESNEAVDADEIPIIDVAGIYSDKLEDRQAVADQVREAAHRIGFFYVVNHGFDHTLTEGVFEQARRFFSLPMEKKMEVDTNLLPNEYLGYHSMASYNRNGRKHNDLSEAFNLAYASDQDPENPDNDRGSSIWPTDLPGFREGLYAYHTPMLQFARKMAQIFALALHLPENYFDKWTRLPEAGLRIIHYPEQEASVDDQNGIGAHTDFECFTIVNQDMSGGLEVLGKSGRWIRAKPVPGSFVVNIADCFMRQTNDYFVSTVHRVINKSGRERYSIPFFFGMDRDMVMEPIPSCISEENPAKYPVITAGEYYLWRAKKAKQADDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZB92</accession>
    <name>A0A0D1ZB92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_11264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230518.1">
        <property type="nucleotide sequence ID" value="XM_016385574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZB92"/>
    <dbReference type="STRING" id="91928.A0A0D1ZB92"/>
    <dbReference type="GeneID" id="27338347"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11264"/>
    <dbReference type="HOGENOM" id="CLU_099502_0_0_1"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW10302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="176" mass="19828" checksum="7A6B2CB603348EDD" modified="2015-04-29" version="1">MSARFGLRFAQNSARQTSSFTTRTPFQFRNTIFRRWQGTATNPAVDAAPQQSLLQRLWTSEVGIKTVHFWAPVMKWGVVLAGATDFLRPAEKLSLTQNLALMATGSIWTRWCFIIRPQNMLLAAVNFCLFIVGTIQCTRIFLYNQSVKGTQGAIEQMEKDVVAPVKKLEAAVEQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZBT7</accession>
    <name>A0A0D1ZBT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230668.1">
        <property type="nucleotide sequence ID" value="XM_016385724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZBT7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZBT7"/>
    <dbReference type="GeneID" id="27338499"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11416"/>
    <dbReference type="HOGENOM" id="CLU_801671_0_0_1"/>
    <dbReference type="OrthoDB" id="4142615at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40704" checksum="9DCF13FDD88455BB" modified="2015-04-29" version="1">MPQPVNVDKTRTCRYWALGPACPNIDAFGTITCSYAHWDTGRLASHHQQRGTCIPWKYYGYCGRGVGCWYEHRDTGVDGLFQGTIDLNGIELEIADAASKAGFDTFNHEALFDLIWAVKRVALKTSAAQLAPPFLPRTSIYPDRYRPRRFGKKSRKKSKTKAFRQPPNLNVELKFHPVKPLMRKRPHTDVKEEDLIDFTAASDTVRRPLQPTSHRVSVKRQKILKHESMPKGGLQPTSTMKPPSSAYSISTGASREPQATLASSQTAIPNPGFEVAPPLAPETEITNQLNQVKAKLDDARMNMNHCQSAMKELFDVHCHRFDNNQIMASLQKLSDCMNKIYDGSKAGAGEIEAVVDLVNGRELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZBU2</accession>
    <name>A0A0D1ZBU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230673.1">
        <property type="nucleotide sequence ID" value="XM_016385729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZBU2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZBU2"/>
    <dbReference type="GeneID" id="27338504"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11421"/>
    <dbReference type="HOGENOM" id="CLU_067237_2_0_1"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="216" mass="24558" checksum="7A11C3A073285758" modified="2015-04-29" version="1">MADSKSAYGKSAASDTDFRRTWDRSEYEAKAKKDQEERKEEAKARYEAKLEGKKWHKQVDMSSLDATSARGSRLDVASMVGKSTLVPAGAGVGKRGKGAGFYCEACDLTYKDNVQYIEHLNSKQHLINTGQSGEVKRATLQDVHERLEMLKARKRQQEEEDKRLGEVDIQARIKKAEELDAAEREEKRRKRNEKRRKGGNGIKQEDQWEGRLGIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZDV8</accession>
    <name>A0A0D1ZDV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231408.1">
        <property type="nucleotide sequence ID" value="XM_016384806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZDV8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZDV8"/>
    <dbReference type="GeneID" id="27337575"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10492"/>
    <dbReference type="HOGENOM" id="CLU_047725_0_1_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36683" checksum="AB6D1D46188054D3" modified="2015-04-29" version="1">MAPAVLIGELSDTAADGFSKADTTSKPLKSSKSPLPEVMELDSASATVEDVVAALKVAGGVIVRNFLRSEEVNRILEDVNPYLEADKPWDGDFFPPETRRAFGMMGKSRTFATSIVGSPLWLGVTDALLTSHSKYNWVGDNNEESISAPQVHNTIVFRIGPGARAQALHRDDGPHYPDHRAVPEHVLGRDSGIGLFVAGTKATKANGATRFIPGSHLWDYREGPPREDQIVQPELNPGDAFMMLSGCFHGGSANTTEDEYRILLSTFSTRGWLRQEENQYLSNSIESIKDLPPALQERMGYGLSRPFLGWVELKSPMLLLHPESSKHQKDLWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZDY6</accession>
    <name>A0A0D1ZDY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoglycerate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231438.1">
        <property type="nucleotide sequence ID" value="XM_016384836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZDY6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZDY6"/>
    <dbReference type="GeneID" id="27337605"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10522"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF264">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="54"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="118"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="36409" checksum="5AD5F6210F9BB784" modified="2015-04-29" version="1">MAPAAVTPPLSPSSEVKPTVYFLDSFDSTATARAESFFRCIHPSDPGHASWRDNAKYLLVRGSYVTADDIAQAPLLRAIGKQGVGIDKIDVAACTAKGIKVFNTPGVNARAVAELVVALTTGLARQIRPVSLKLHEGQVVRKEQCSGLILHKSTIGIIGMGNIGKTVAKIFKGGYESDIVAYDPYMPEGAWEDLPHKRVRNLEDLLAISDVVTIHVPLTSETKDLIGLEQMRTMKPNALLINTARGGIVNEKDLVQALNAGYIWGAGLDCHEQEPPTRERYEELWQHPNVISLPHVGAATAQTQRETALAAVERLWAYVQQVEDIEPEMFEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZE03</accession>
    <name>A0A0D1ZE03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetylglucosaminyl transferase component Gpi1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231458.1">
        <property type="nucleotide sequence ID" value="XM_016384856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZE03"/>
    <dbReference type="STRING" id="91928.A0A0D1ZE03"/>
    <dbReference type="GeneID" id="27337625"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10542"/>
    <dbReference type="HOGENOM" id="CLU_007914_2_0_1"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="78421" checksum="2BA47616EFABF5F9" modified="2015-04-29" version="1">MGTLFRNSPYPVVRIFQLCDRTNMHVLGTLNYPDLPDRFEPSKICAFTVPGGKRPYIYCPPDSGLSVQIVLFDPPNPTQMQYVSLEPISLALGRTAQRPRWLADEVEIQEEQEKDRVEHLVAKLRFHTVVRHAPTRKETALTSILRQINCAQEVADLLQKNTPLVGPRRKRSLSVSERVVESAQSLYAFAAWSLWTLFMTYAFPTLLYLFKIALIGHRILAEGVLQVLEWPLPLKRLHLPESRQSIHGVFALKDISACCQQVHLRLQQFSYYPTQYSLLRRRHATWSSFPTTNSDYIRFYNSLWLVANDVIIGIALGSFLSDNAAATAQFIGAVLNEYTVEGLKRVIRWLMSYPGGLKLNTELAAFMGDLFLWVIEYWSSTIVMLILPRLPMIVYFIAFSSFAGASMPIAILSDLLSLTTIHIYSFYVASARIFNWQLTIIVSLFHLFRGKKRNVLRNRIDNCDYDLDQLLLGTILFTLLFFLLPTVMVFYLTFALARMAIISLKATLDTCLACLNHFPLFALMLRIKDSKRLPGGVHFELLNAEQSQPPRQNGTEHPESTSRDHAEYDDDEALATSVAYIRLSSTPLSLRQIFEQYFQLGARIRQHYLSPKVVFRLCSGRFVPPLGRSEMYGLQYSALPRERATISEVWKNLRESESAPVNGTVAKSLNRQASLDTLGRAMSRQWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZKK3</accession>
    <name>A0A0D1ZKK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233573.1">
        <property type="nucleotide sequence ID" value="XM_016382870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZKK3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZKK3"/>
    <dbReference type="GeneID" id="27335628"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08545"/>
    <dbReference type="HOGENOM" id="CLU_008511_0_1_1"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="248"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="584"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW13357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="659" mass="73445" checksum="AFA414E48BC481B7" modified="2015-04-29" version="1">MWLQSASQPGNYKSAKTAVGLQPQMQMLAGTDDGLASQISPQLRSSTNTVMDENDTSEDAIDGPSSNIAFLRHISEAFAQASGQRQVTKATLNPSNPTGDWVCVTHAQGDISGNTFNPSEDGINIYALPSETRTRVLIDEYFQKTGQLLPIIHEASFRETFIEMKRSNFTATRRTWLGLVNIILALGCTLIVDGDDTAKERIAESDMYCQRANRLCEREPRKSISLELVQYLLLMGQYLQGTQKSVQAWTVHYLAISTAFQLGLHSPRTNAGFPPVEGEVRKRVWFGCILLDRTLSMTFGRPCIISKKHVRLELPSANIQIMGQTPESAAIQHMDARYFQATIKLNNILYEVLDTCYEQNIGPAETHADAQILSMTLKGDQQLDEWRSQIVPALGLRILHTPLVSQDLGNFELKDKIVERFNLVLSLRFHNLRILNHRRILEKFLNSTKGVNDVEANMIRQVYVSSIETCLESSINIVAIVHHVVLSHGWHRDLLGAWNYSLFYTFNAGLVLIAALLVAAKGSDTERVQTLPSWKYLDNAMMYVNMAVEALQNLDRGNRVVQGIVDYLSHLAMACSSLLSKPGTTHNDRNVDQHGPHAATGNSLSPQQAPQAGASYRAFSQLPEVFNIESNLSGFMLDTDVDSFFRLSDPDSLDLNGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZKW0</accession>
    <name>A0A0D1ZKW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233673.1">
        <property type="nucleotide sequence ID" value="XM_016382970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZKW0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZKW0"/>
    <dbReference type="GeneID" id="27335728"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08645"/>
    <dbReference type="HOGENOM" id="CLU_047725_0_1_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44920" checksum="E43977635FED7A03" modified="2015-04-29" version="1">MAPSAVEIAVPVAKTIDSTDSRKEADELKSPASPLPEVKIFDAASATVEDLVDAITVAGGVVIRNVLSQDELANLERDIRPELEKDTAWGDGDFFPAETRRAFGLVTKSKTFADRIFGHPLWTGVTDALLTSTLKHNWIGDKNELSVSRPQLNNTIVFSINPGARDQALHRDDAIHHIYHPAAAKHEIGRDAGVGFFVAGKRTTKRNGATRFIPGSHLWDYAAGPPEETQTFYAELEPGDGFMVLSGCFHGGSANKTDQPDENGEIHPEERLVYSTFMTRGWLRQEENQYLINPVEKVRELPEWMQEKVGYGLSRPFLGWVNLKSAMEWLHPNRGRRTGDLCDEYCPNCDNHFVIDAVTPKAALKVESEDTRMDARMLKDERVRQPEQRTIFDVREAAEKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZLD7</accession>
    <name>A0A0D1ZLD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_08823</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233848.1">
        <property type="nucleotide sequence ID" value="XM_016383145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZLD7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZLD7"/>
    <dbReference type="GeneID" id="27335906"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08823"/>
    <dbReference type="HOGENOM" id="CLU_008635_5_1_1"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="25"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="476"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW13632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="592" mass="66091" checksum="E03A910037BB96CD" modified="2015-04-29" version="1">MPTLVITNFNIVCSVLGGFITVFGLVSYLLKERFYLSEALISLVAGIIFSPHATNWIRPLDYADGVVENLDTITLYFTRLVLGVQLVLAGVQLPSRYLYTEWRSLFLLLGPGMTLMWLSGSLLIWAMVPHLSFLHALAVAACVTPTDPVLSNSIVKGKFADKNIPKPLQKIIIAESGANDGLGYPFLFLALYLIKYTQMGGAGHPNPGGAAKAMGYWFGETWGYTILLSVVYGIAVGWLAKELLHYAEEKKFVDRESFLVFAITLALFITGTCGLIGSDDVLACFVAGNVFTWDDWFRLETADDSLQPTIDMLLNISVFIWFGAVCPWAEFRTNDVIPLYRLVFLGILILLFRRVPMVFAMHKKIREIEEVQQAAFVGFFGPIGVSAIFYLYISLEFLNTVTVDGEVREDAARLQEVMRVVIWFLAICSIVVHGLSVPLGKLGYHFPRTISQALSSDREDDDYDLRFRRAQQFNQTLNIRRRKKNTTGDSASKQQQPQQPPSPAVFSLSRPQKGSSELGDSEARSNNPPEPHRPIHFPDEPSERQQSPATSDRRIQFSRNTPSDGMSTPSSLRRDVGERGQDIRDGHDRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZS27</accession>
    <name>A0A0D1ZS27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235803.1">
        <property type="nucleotide sequence ID" value="XM_016379976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZS27"/>
    <dbReference type="GeneID" id="27332718"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05635"/>
    <dbReference type="HOGENOM" id="CLU_046731_0_0_1"/>
    <dbReference type="OrthoDB" id="5366256at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="34871" checksum="1B138CDAD6EFB60E" modified="2015-04-29" version="1">MATQVISAPPAHHLPQQFGYDSDMMSSYHQLESFPSAHGSYTSEHSRQPLLMVSPPNASSDIPFRRRSSHSPRSGLVAPVSHNRTPIRHNRGSVMNDRSHTRGDMIMSYAAEENTLYPSQSLPSTVGIRSQSGPSMAQMYGMSAYPMSPPLASFGHQGGYFGSQLQSNVGQPESGEFPLTQGEGEIQNFYTVGRTSSQGSAMSLPNAESPNAMYLTRTQGHQSLPSVGVTMQPFPPVPSTLESSPAESEIMPSRPKPQCWDHGCNGRQFSTFSNLLRHQREKSGSATKAICPHCGTEFTRTTARNGHMSGGKCKGKPTPGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTQ4</accession>
    <name>A0A0D1ZTQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_06203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236368.1">
        <property type="nucleotide sequence ID" value="XM_016380541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZTQ4"/>
    <dbReference type="GeneID" id="27333286"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06203"/>
    <dbReference type="HOGENOM" id="CLU_062358_0_0_1"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046312">
        <property type="entry name" value="DUF6454"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20055">
        <property type="entry name" value="DUF6454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="353" mass="38394" checksum="235F36A625843AB0" modified="2015-04-29" version="1">MKAFPYSAIAAVLSASSTFVGGLAANVTIYQPSVAFVPTPLPAPGPASNFEAIIEQFNLLGRTTAWNLVKKIKFEGDTGEPEGMVNLGEERYILGGGQWTNKTVSYGKNVIINGTDRTPGSGYAHLTVYDGQGKRIADATLTEPGAIEYHIGGIEYDGEKIWATIAQYRPNTTATIVSVDPTTLEDQNVFHYADHLGGIVHDTQKLELSTLNWGARNASVWDLKTAPGAACPYPAFSQPKSVARNPTYFVDYQDCKFLGYSQVYAGRPTMMCSGVATYSNNVTVGGIAIVDTETMVPYSEVPVTLVSDLGTPITQNPFDVALVNGRMRLYFLPDQRNSTLYVYEAEEESPYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWD4</accession>
    <name>A0A0D1ZWD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_04168</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237193.1">
        <property type="nucleotide sequence ID" value="XM_016378516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWD4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZWD4"/>
    <dbReference type="GeneID" id="27331251"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04168"/>
    <dbReference type="HOGENOM" id="CLU_014629_3_1_1"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="16">
        <location>
            <begin position="30"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="17">
        <location>
            <begin position="295"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="15">
        <location>
            <begin position="507"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW16977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="709" mass="79907" checksum="18109F15FD80DFE7" modified="2015-04-29" version="1">MADFTADLQPADVQAPSILARERAASSIHVDELARHLLWRNDFLDRQKKILTILEAMPIFSKKNQLNISRPDRFHLALARAKTLRRLSLKYGWDRDDFLMAEYLIDEMHPFALHWGMFATSLREQCNDKQRAYWLPKVDNWDIIGCYGQTELGHGSNVRGIECQAKWDPQTKEFIIHSPTITASKWWNGALGRTANHAIVVAQLMLPTPGASSDKYKSYGPHQFILQIRDMKTHKPLNGIVIGDIGPKYGYPGMDNGYMLFNNFRVPHSALLSKHSGVDPQHGTYIKPKNPALVYGTMTFIRAQIIMHARLVLARAVTIAVRYLSIRHQFSDRDSGTGVPEEAVLNYPTVQIRVLPLLATTFALHYTGETMFKLYWGTRQQIETGDTSSLAEMHAASSGLKSLCTTLAADGIETCRRAMGGHGFGGGSGMINLNNEYLSKPTVEGDNWMITQQTASYLIKRMQRAVEEPNLEPTDFVDAHFQEYVKCTESCRTEGNHSDLTKDSIALVDAFKQRVSFLAYKVYRERVVEKKSWTGLMISLHKLSRAHSESLLVSNFHEAVFTKTPHPPLNEATVSVLQTLFRLFALFTLDASASEFLVSKALTIETIPDVSLAIQELLTQVRPDAVRLVDAWSIPDFVLESALGSYDGDVYNRLFYKAHKENPLNRVTFNPDWKTEEVVMGEGEENARRRLEALVLGVTVDETSAKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZXH5</accession>
    <name>A0A0D1ZXH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Probable beta-glucosidase E</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Beta-D-glucoside glucohydrolase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Cellobiase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Gentiobiase E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PV08_04571</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237593.1">
        <property type="nucleotide sequence ID" value="XM_016378916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZXH5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZXH5"/>
    <dbReference type="GeneID" id="27331654"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04571"/>
    <dbReference type="HOGENOM" id="CLU_004542_2_0_1"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF20">
        <property type="entry name" value="BETA-GLUCOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="23">
        <location>
            <begin position="858"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KIW17377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="945" mass="102095" checksum="3AFA5EA992F478F1" modified="2015-04-29" version="1">MSPVKPRYQPLQNNDSGARLGDGDLSDEDVKPHSRSDGHLLDPAGASTGKSSRYSSKSVSSRICGGRKLTKTYIAISVLVVAVFTSVIGGGGYWIYSTGQINGQSPPWYPTPRGGTLPSWKDSYEKARKLVDRMSLVEKVNITTGTGWSMDLCVGNTAPAINAGFPGLCLQDGPLGIRFTDHATSFPAGLTVGATFNRDLMRRRGAAHARQAKLKGVNILLGPSMGPLGRNPAGGRVWEGFGSDPVLQGVAASETIRGIQSQGVIATAKHFVGNEQEHFRKSFEWGLPEALSSNIDDRTLHELYAWPFAESIRAGVASVMCSYQMVNNSYACANSKLMNGILKDEMGFQGFVQSDWLAQRSGVASALAGLDMSMPGDGLYWQNGKALFGDQLTIAVLNGSVPMSRLNDMVLRVVAAWYQLGQDLWPPALPNFSSWTDDKYGLLHHGSSTTQPKVVVNQFIETEDDESRNIARQVAIEGTVLLKNEDSLLPLSPRLEELGTSGKRKVAIVGEDAGPGKGANYCEDRACNQGTLAVGWGSGATEFTYLVDPLSALNASFDKSAVDITVSLTNSVSSRLQTTLGEQDLCIVFGNADSGEGHRIWASQRADRNDLEMQKGAGTLIKNVAEACGGPVIVVIHSVGPVLVEGVADLPSVKAILFANLPGQESGNALADVLFGRADASGRLPYTLGKSLDDYGPGAPVLYYPNAIIPQVDFKEGLFIDYRHFDKHNIEPRYPFGHGLSYTTFQFADLKVTSLKAKSPRPSPKPESLAPPAMNEEIPEAESAIFPPGFSKLKKFIYPYISSTGQVRKGNYPYPDGYELKRQPSQAGGGEGGNPALFEEYVSVQVKLENIGPRKGKEVVQIYVTFPPSIQEPSTGELVETPVKVLRNFTKVELEAGDSQVVNLTLTRKDLSYWSVVQQNWIMPDGTFKILVGRSSQDLPLQGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZXK3</accession>
    <name>A0A0D1ZXK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NOL1/NOP2/Sun domain family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_04596</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15836"/>
            <dbReference type="Rhea" id="RHEA-COMP:15837"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237618.1">
        <property type="nucleotide sequence ID" value="XM_016378941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZXK3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZXK3"/>
    <dbReference type="GeneID" id="27331679"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04596"/>
    <dbReference type="HOGENOM" id="CLU_041061_2_0_1"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF3">
        <property type="entry name" value="5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="13">
        <location>
            <begin position="80"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="361"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW17402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="455" mass="51215" checksum="0FF92A24B3008D85" modified="2015-04-29" version="1">MGKPTQKEKARYQLLRQKLLDTYRGHFDDILSKPPTAAVDQTQHRWETLYPALLKPTRHAVLLNTFHGEPYFQHPGEAPTNPRLGGSLDERLRNFDLKSSGEVSPLELLEDAGRWLPPSCPLQLYHLPQQQTDSSKEYLLPPPLKNLHGLKNYYCLDFASVFPVLALDVHPGHTILDMTAAPGGKTLSLLNHLRSSLVPTTDTTASASTIKTRLHVNEIDFQRRKRLRVVLDEYVPANLLPSTSSTNSIVQITGKDATEASSFRAETYDRILLDAPCSSERHVLHQLHKQESASNLHKDLLNWSPSSSEKIAKSLQLKMLTNAVQALKFGGTVVYSTCSLSPHENDDVIENVVRLVDKQNRKRTKDALRRREADRESGDDSNIEKDGAEDVPHPPTKPAQTPLPELWTLEIDHASWSIGEPTKHGWMILPDQQDNAGWGPIYFCKITKKRKKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZ42</accession>
    <name>A0A0D1ZZ42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238143.1">
        <property type="nucleotide sequence ID" value="XM_016379466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZ42"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZ42"/>
    <dbReference type="GeneID" id="27332205"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05122"/>
    <dbReference type="HOGENOM" id="CLU_048587_2_0_1"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="327" mass="35881" checksum="E74515F1861E38D6" modified="2015-04-29" version="1">MPAHGNYTTEKVRYPSHGETIGAVLFRPNGVAKPPGIVLTGPYSFIKEQAPYQYGTRLADEGYAALIFDPRTVGESTGTPRRLENPKMKNEDAVAGLDYLVSRGDVDTSRLFVVGICQGGPQSLDIASYDDRVKAAASVTGYYRDHETDIYMVSVGCVAWKPGVDISTLKMPTSEQGEALLKARLERARKARELYDTTGEVVYQPLVDPTAADPDTGALAGLPGPTVWAWYGPWTLKGFENRYAVMSDLDHFSYTTVPGVAKLNKPALLIHGDNCMNPPAAKRHFESIPAVNKKLIWNNDISHFQHYDQPDVVDRNVGDIAKFFAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A2Q5</accession>
    <name>A0A0D2A2Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_03521</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239443.1">
        <property type="nucleotide sequence ID" value="XM_016377873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A2Q5"/>
    <dbReference type="STRING" id="91928.A0A0D2A2Q5"/>
    <dbReference type="GeneID" id="27330604"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03521"/>
    <dbReference type="HOGENOM" id="CLU_019326_1_0_1"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000060">
        <property type="entry name" value="Putative metallocarboxypeptidase ecm14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238127" description="Inactive metallocarboxypeptidase ECM14" evidence="18">
        <location>
            <begin position="20"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="19">
        <location>
            <begin position="197"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW19227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="574" mass="66063" checksum="A9F745D8B2CD0271" modified="2015-04-29" version="1">MASLRLILLLVVFIAFVNCLPPTQCHSSLRPKTSYPAKERPGGLYRRFRDSIIEKIWNIRGRNGEEECYNTELAPRIPARFHIRYGDDAVLRFQIRTEDEAKALSKVIRMLYIDVWDATDDWVDVRIQKAVLPSFIGLLPSSLHHAYKPLIHDLPRAVYDTYPSSPYSLETPLLSSLTALNRGRTHVGTPQDLFFQDYQPLSVIYPWLRLMASMYPTHAELISIGQSPEERDIPALRIGAKTQPGDEHDVRHTLLIVGGAHAREWIGVSTVAYIAYNLITRYGHPHFPAVTKLLDHFDLVFVPVLNPDGYEYTWTTDRFWRKNRQSTHLPFCPGIDLDRSFRFEWDGHDLDNACSDDYPGPAPLAAKEAQLLTDWARGQMEDRNVSFVSYLDFHSYSQEILYPYTYTCDIDPPNLEDLEEVALGLAKSFRLTNGHYYDVERACSGSTTYRDKVDKIRVQVDPQGGSALDFFYHDLDVKLAFQIKLRDTGTYGFLLPKSQIVPTGEEAYEAVMALGRWLLGNHGIESLDPETVWGVETEAATTKDGQDQSENNEYEDYEEDDEWWQDLRKRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A474</accession>
    <name>A0A0D2A474_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="8" type="ORF">PV08_00221</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239863.1">
        <property type="nucleotide sequence ID" value="XM_016374587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A474"/>
    <dbReference type="STRING" id="91928.A0A0D2A474"/>
    <dbReference type="GeneID" id="27327304"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00221"/>
    <dbReference type="HOGENOM" id="CLU_042432_3_1_1"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="196"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="364" mass="40807" checksum="0573DC734C4EE734" modified="2015-04-29" version="1">MSTRPAVCRLGTQFACCHPVKALSLPRRPFFGRAHPERWRSRRGGGATTPPFLRNHSTTHHSPPTSSSSSSSSSVSPNEVNHFSRLASTWWDPHGPSRLLHLMNPHRHDFIKACLSPTTTTPSDQQYTYLDIGCGGGIFASSAARLPSTRSVTAIDPTPLVIEVAKSNQRSDPALSPPKLTYLNCAIEDLPRYTESEDEEGEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYDFITVFEVLEHIPDPSSFLDIASAHLKPGGWLIGSTISRSTTAWLTTKVIAEAPLVGVVPAGTHDWNQYINPDELRGYFDSRAGVWTDFRTQGVVYVPALGWKNVNGSEEFGNYFFGVKKRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5V2</accession>
    <name>A0A0D2A5V2_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PV08_00732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240373.1">
        <property type="nucleotide sequence ID" value="XM_016375097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5V2"/>
    <dbReference type="STRING" id="91928.A0A0D2A5V2"/>
    <dbReference type="GeneID" id="27327815"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00732"/>
    <dbReference type="HOGENOM" id="CLU_047851_1_0_1"/>
    <dbReference type="OrthoDB" id="5427526at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="455" mass="50356" checksum="D68E7E70ABD664F1" modified="2015-04-29" version="1">MTVTSPPASPSTPSRKRRSLRLSSVDSLQETISTSPYTSGTTNGTAYSRRSSRTSQTSYQPRSPMTPRPISAKSSRPPSFSIQRRESRTSIRSTRSIEQQEENGLGNLADELGQAWDDEEEGGSNFLEGLREGDVEQDHSLHGLQSPYAINDMHDFGFGMVVQSPHPAQYDGASPALQVPSSQAIDLRPPTHPKRGHQRHESAYDGSDYGPESDADGAEEEEEATLPPILRKRIHDIQKLTRMCANPEDAVSEGGGTVKRTIQGLKDLGPQGNVEYGVTRLITAYTSMASHRTNKTRDLFTQSHSLIYGGMAHLPEEMVDVLLEEITTLMSTLPFLRPQNPLISLQILASQTDELSQTLRSLTDLLQESRLAASAATRKLKSVRDMVEDMNVEDELVENSIMLIQAGDWDRRCRTRQAAKTCQEVCEGFADRWGLTMDVDLTAKRRPLQEVSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A6H7</accession>
    <name>A0A0D2A6H7_9EURO</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
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        <name evidence="5" type="ORF">PV08_00957</name>
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        <name type="scientific">Exophiala spinifera</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016375322.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27328040"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00957"/>
    <dbReference type="HOGENOM" id="CLU_045495_2_1_1"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="328" mass="39403" checksum="B422F638C90BB1C2" modified="2015-04-29" version="1">MNAIRQTQALNKRELENATPPSASWHADYRDTAYIYIGGLNLDLTEGDVVTIFSQFGNPTHLNLIRDKETGKSKGFAFLKYEDQRSCDLAVDNLTGADILGRLIRVDHTRYKKRDDEDEDTYRIGRLEAEAEADVNGNGKRGSDDTEDDDERGSRHRRKKHRPALREEQELEQMLAITQDGDAGEEDPMREYLIREKREEVERAKERQRSKKDKHRHRRRDSGDEDEKRRHRHRHRDEDEDRTKDEHKRRRHGDEEDDAAEERRHRRRHRHRDEEDHGRDRSERTRHSERDTDRDHGESKKSHRDRDEKREDRGWRRRRSDSRDRNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7C7</accession>
    <name>A0A0D2A7C7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240893.1">
        <property type="nucleotide sequence ID" value="XM_016375617.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2A7C7"/>
    <dbReference type="GeneID" id="27328337"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01254"/>
    <dbReference type="HOGENOM" id="CLU_001744_1_0_1"/>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="27"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1502"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1736"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1756" mass="196261" checksum="0766A6CE419D0C7B" modified="2015-04-29" version="1">MDFDALRAQTLRSGADEEAVTVNTRALIDKVLARYSGEWTVLRELLQNAADASATKITIKFETLPSSTVPLPTDSSPSSLLKHTVQNHTLKRLVVTNNGLPFSENDWNRLKRIAEGNPDETKIGAFGVGFYSTFADCENPFVSSGKEAMAFFWKNNSLFTRRLQLPDSEKSGDTNFVLDYRDTTSPVPPLLPLAQFLANSLTFVGLEHIELWIDNWNILSLTKKTSPSYDIAIPRDIEPKTREGFMKVAKVCKEIAQIDGQWMGIIGWKVAKDSTRTADRDSAPSFRKFFSRLAGAIAEEQQPESRPETPSHTEVLASKVSATVFLNVNTATIKTFTGQKFNEELERATKKPPPKFTKLAILTAPYIPDESLTKASAAGDVFGTVLPSRGGKIFIGFPTHQTTGLSAHISAPSVIPTVERESIDLNARYVRTWNMEMLRVAGIVCRIAWSCEMHEIKEKTMREANGRSKIRLEEVSPFLDEAITIFKNFTFRDSTPSGQIGQLLEDAFWTCSKQASIKVVSTCGVLPTHDVRVAPKDMSFMEGIPTLPEKLATEAKVLVSKLIDFGLITEVTVSDIKTALESSPLTAVQVSEFLSWLTKQASRGQLDSNTIKSLLSVAVVNNDDDAGGRSPFLQLGEMKHFLNPSRTPVHLPLPPTVMPHKFTKSMSKDELESLGWEELQLVPWMRWLVAQSGNRQVLTEAQDITTSADFSSQVLPLLSKHWDSLSQSSKTSLVELLAKHTVIPTKFGMKKPGDSYFPNVKLFDDLPTIQKLPNVKEKLLVALGVRKTVELGVVFERLLSMDPKSAKSENTKQPPWSHIDLISYLASVRDDIPKADIQRLRTTPICPKHARDNDAEEHIKRYRISDLFEPRVELRELGLPTLAWQGVYRSNSLEGKFLSSLGLRTTPSVEELVAIMAAAGKMDSQNLDLRDRALAYFLSHHHAHGYGAYNYLSITSPFLPLENKPNNLATPSQCFANPDAARLGFDVLKRDWIPHASKFGIRLNPPMDICINVLAKQPPTNYSDARSIFKYFAGRLGELDGNHIARLQDLQFVPVFAKNREHSAPKTHASPRSVFLGESDVFSEIFNYVDFGDEANSFLVRCHSKLEPTKVEIAQILVKEPARISATFRNVEKYLALLRSMADSSKDLKKNRDLWAEMKRAPFLLASKELPVSQPSEKKPSIGLDDAEPLDEEEAQGIREFQLCSAQDAIIIDDYLNYNLFKTNILAAPQEESLEDFYYMLGSPLLSSLVEEAARHGPRAPDQKSAEKLQKLILERSTLFLHEQPRETIKHDARWLEKNLSVQLVSSISLRRSLKGRNISHTEKRTAVITLVDRQYTLWITGAKPDLYQVSQALVHILLNRPKLHMAITLEMLLRTELLELRARGFNVNRILKQKAAEQRLAESRRQRELEEQQKRIEEEEKAWRASQERATHEESQRKQLPGGFPDSPDSRSLTHNPEVATHTLSTDDSQRRHGRNLFSNLSRQLGLSNNRHIQSMLGQDANEDPRAVAGSDGVREPPPPYHYDQRGGQAGPQQSITAPHQLRENLLNAVKKSRAHSSSDIFSPGETNVLTEKKSYCDERPAHDLTFVADIKHGIQMYLSPSSVDNSSAFLQRHSTGLTAFANLLKGVAEVFSLDPRTINIFFEPSGKTIGFNRNGSIFCNYRYYCDLHEKSAVAVGADGYAEAFVYWWVTLCHELAHNLVGDHSSEHSYYTEGFVAQYFGRVVGAIAQQQAQSASSGPASGPASGPASGPLVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASV3</accession>
    <name>A0A0D2ASV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_11909</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230024.1">
        <property type="nucleotide sequence ID" value="XM_016386216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASV3"/>
    <dbReference type="STRING" id="91928.A0A0D2ASV3"/>
    <dbReference type="GeneID" id="27338992"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11909"/>
    <dbReference type="HOGENOM" id="CLU_066963_4_0_1"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238659" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW09808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="202" mass="23068" checksum="5A22395370DE15DD" modified="2015-04-29" version="1">MRLAAIAAFAGLIGVSLAHNIQLKAHTRECFHEELHKDDKMTVTFQVGDREFGGSGNLDIDFYITDPAGNYETQMTTVSSGDYSFDARMDGRYIYCFSNEHWSANSKEVSFNVHGIVYVPESDAPADPLEREVRQLSELLAQVKDEQTYIVVRERTHRNTAESTNARVKWWSLFQLGVLIGEGVFQVWWLKRFFEVNGRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT70</accession>
    <name>A0A0D2AT70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_12004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847503">
        <property type="protein sequence ID" value="KIW09720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229936.1">
        <property type="nucleotide sequence ID" value="XM_016386311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT70"/>
    <dbReference type="GeneID" id="27339087"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12004"/>
    <dbReference type="HOGENOM" id="CLU_019095_0_2_1"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238562" description="DUF7492 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="2">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="259" mass="27986" checksum="4E5BACB58BBDF92A" modified="2015-04-29" version="1">MTLLAGIGLLLCSLTLVNCHTWIEQLSLVDQDGQPVGDPGFIRGYVPRTTPGFVDGDNTYLLPQAPALTFQDSDLMCKLTQTQGNQSGGSVLMAPQGSSVLLRYLENGHITQPDVPPNKPTPGQVSVYATTQARDDDKFTAIHGQWTADKTGGDQRGLLLTSTPFDDGRCFQFDPTGHSEIATTRSNTFGPGPSITEAPNRWCGTTIELNDETGIPFANGTLLTLYWVWDWPSIVPGNPGTPPAILNETYTSCMEVEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT81</accession>
    <name>A0A0D2AT81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230139.1">
        <property type="nucleotide sequence ID" value="XM_016386007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT81"/>
    <dbReference type="GeneID" id="27338782"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11699"/>
    <dbReference type="HOGENOM" id="CLU_028818_2_1_1"/>
    <dbReference type="OrthoDB" id="5086080at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF7">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="55107" checksum="7C24FE9BCC7E9612" modified="2015-04-29" version="1">MSRSRTTKSKLTDAQLQRKRECDREAQKQIRLKTKTRIAHLENLVATLQQSDGTRSQVSDLVRQVTKGHEEITRLREALRAIGKQVEGSLRSSSRDSTQLVGEDPGSRPYTSNDEEVFPDFVDSLEQQKSTDGSPTNTDDPSQPEDAQREGCKSARINNTTAHAESINAHVDSTDTLELSIVNMVAGTDESITSLHLDLSTPEMPLDTLTSAESSLASLPISEMAAQITQDKSLDGRLWYLAGTLLNLILAVEDKERTPDEYNDDIPIRAVLHGWPAVAARYTLDLGWQWIRQLDEKMYSSLGVPERLSVMRLMRIQYQVQAHPDTMSSVTVPSFMVPRPAQAHIQHDPLIEHWVWPGLREQLLFNPFMCATNRFMDNFRESLHFLWPFDPTDAYCRNSLTGMYSFSTMFLDRSSDLRSHCLSKKFLDLFPQLKPDIPSFDVSLWNQNLLLTTTLDSAISWQSKPLTPEEDSDDLLPLELYLDSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATN6</accession>
    <name>A0A0D2ATN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230091.1">
        <property type="nucleotide sequence ID" value="XM_016386283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATN6"/>
    <dbReference type="STRING" id="91928.A0A0D2ATN6"/>
    <dbReference type="GeneID" id="27339059"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11976"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW09875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="494" mass="53092" checksum="55357C2A3AF7ED6F" modified="2015-04-29" version="1">MVTNAANDAASMKAYKPRYIEEKLFINGEFVPSISGRKFDVYNPTTEELAASVYEANADDVDLAVQAAQNAFPAWSALSAADRIGYLDRLADAIEANADELAYLEAITMGKPYIDDFSIKLSVRNLRYFSGKALDVVGDSSLNTRDFVNITLRQPYGVCGGITPWNVPLLMLINKLGPALATGNTLVLKSSEKSPLSSLVVGRLAQEIGLPKGVLNILSGYGRPCGEAIAKHMSIRKLSFTGSVAAGRAIKKAAAESNLKKVTLELGGKSPLIIFGDADLAKAVPAATASILLNSGQSCVASSRIYVHESVSTEFMELMKKAMAELLPAGDPLLPGSRRGPQVDKAQFDRVVSFLDYARDNQLEIPVGGGRQGTTGYFVEATMIANAPENSRVMKEEIFGPVVCVNTFADEAEALQRANDTEFGLYASVFTKDISRALRVAKVLEAGSVGINCSSPTMAVDMPFGGWKQSGDGRELSKYCNDYWTELKSVYIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AU01</accession>
    <name>A0A0D2AU01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_11184</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230439.1">
        <property type="nucleotide sequence ID" value="XM_016385495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AU01"/>
    <dbReference type="STRING" id="91928.A0A0D2AU01"/>
    <dbReference type="GeneID" id="27338267"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11184"/>
    <dbReference type="HOGENOM" id="CLU_015739_0_0_1"/>
    <dbReference type="OrthoDB" id="3341590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015328">
        <property type="entry name" value="DUF1965"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09248">
        <property type="entry name" value="DUF1965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238619" description="Amine oxidase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1965" evidence="12">
        <location>
            <begin position="263"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="11">
        <location>
            <begin position="338"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW10223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="789" mass="87891" checksum="8E791195DB3311C8" modified="2015-04-29" version="1">MKGSFLTAVLVGLTALTAPIAAAPDPRLSRRGRSGDTGLPLQPLERRLLHARDSCPAPVDIPTTAPKDSPFVPLSQAEIDSVVEWLLSPSQGLNLTNTSSPTLSLSDNYIWRVDVFKPNKTDVLAYLDGNATAVPRYALVALIQGGLDEPIVAEYTVGPLPISEDTVIRSSDWVYNGVNGAKVLWSAGWVDSVRQAAIDDLVNATVSPIADLTVDLLDMAFYGAGDPRTNMTYFASNPSSTDGSKSIFWSPFRRLGIEPWDQPSDLYIQFDVTGTDASLWKALKVVYNLQVYSSVQAFYEAWKSGQVTKTPPPTTNIEFLYKNKTGPTRELEDRLAPTIVAPEGNRFKIDRPNQYVEYLGWTFYIRFDYEVGVQFFDVKFKGERILYELSLQDAIAQYAGHNPFQAGTAYMDRFYGIGSSAIRMIPGYDCPYHATYLDGTYSPGVESHTENSTICIFETDTGTPITRHNDPTWAQATKGSKLVVRMIATVGNYDYLWDYGFYVDGTLSVDAHASGYIQGNYYRPDDEGQWGPRVEQTLAGTLHTHVMNFKADFDLIDEKNTFVKTEIVVENITQPWFEELGEFEMMRYNITEVQTEDDGLIYHGPNGQTMFTVVNKDQKNKWGEPRGYRIIPGLSNVHLASRNSPFFRKNAQFAKQPIAVSHQHDTEPASSATLNQNVPEAPLVEFWNFFDGEPLVQEDLVTWVNLGMHHYTRAEDIPNTMMSEAHSSILFAPQNWGNTEGTKDLSNAVMFYAEGEDNQIVIDQNGVLPPPCLALGPEDSLQGVFEVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVZ4</accession>
    <name>A0A0D2AVZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230836.1">
        <property type="nucleotide sequence ID" value="XM_016385892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVZ4"/>
    <dbReference type="STRING" id="91928.A0A0D2AVZ4"/>
    <dbReference type="GeneID" id="27338667"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11584"/>
    <dbReference type="HOGENOM" id="CLU_023620_2_1_1"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="116"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="506" mass="52193" checksum="B62CC0469D7C1A3C" modified="2015-04-29" version="1">MTRRQVTLQPNSSSSSTSSTTCAGASTDSRNASYSPFTEDHASPTPLAMRTTIPPQPSDKSRVQLISTSVLIPGRGKPRHDMTVVVRDALIHAIHPTSALPAFLQHHSLPATHVPVLLPGLWDCHTHFLGTKSLNLSEVVSTHAAVAGARLARNARDILLSGFTSVRDLGGYAIELSKAISESSLPGPNIYSAASAISQTSGHGDLFDLPVDVAHSRLSTTCPNAGSYPLLLADGADACRMAVRLVTRRGAKCVKVFASGGVLSILDDPLHAQYSAGELEAIVDEAARAGLAVAAHCHGKAGILAALRAGCHTIEHGTYLDAECVEVMLAKGAVLVPTRTVVKVGVDHPELMSPESYVKMLETAKYHRAAYRLAVRSGVKIALGTDLGISVPVDNPLALGRSGGELSYAVTDGGMTPLQAIEAATAMGPETLGHLGAAPKSGQIREGYDADLIALCANPLDDIAGDGGGGGGGGGGGGGGGGGMELFKDPQNVTHVWKGGVCYKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXB2</accession>
    <name>A0A0D2AXB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GID complex catalytic subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_10663</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RMD5/GID2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231579.1">
        <property type="nucleotide sequence ID" value="XM_016384977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXB2"/>
    <dbReference type="STRING" id="91928.A0A0D2AXB2"/>
    <dbReference type="GeneID" id="27337746"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10663"/>
    <dbReference type="HOGENOM" id="CLU_020227_0_0_1"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="13">
        <location>
            <begin position="165"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="14">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="12">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW11363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="410" mass="46515" checksum="C24A34B2625492E8" modified="2015-04-29" version="1">MDTIQKEHDKVRNNSKQSQTLQNVDDIIKQLQSAREAIAEDPNSRQITLAKLQNPVKASFDGIFTGLKDTHGLHNKYTRALDKVFKEKVPSSDIDALSSQPTLIKRSIYLHLLREGLFDVASTFHAEALERQNQQHETAAKLGLDVSMEHPLGLDKSSEENMQEQFSNMYRIVKELKDNHNLQPAIQWARANAAALEARGSNLEFELCRLHFVSLFLEDQDKDPHGIDGPMRALQYAQAEFQSFRGRYLVEIQQLIGAIPFYSNLEESPYQLRFDNSTAWDDVATSFTREFCSLLELSADSPLYIAATAGAIALPTLMKLQTIQKQKRTEWTSQNELPVETPLPPSYRFHSIFVCPVSKEQTTDQNPPMMLPCCHVIAQESLQKLSKGSKLKCPYCPIESHPKDAIRVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2G2</accession>
    <name>A0A0D2B2G2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233304.1">
        <property type="nucleotide sequence ID" value="XM_016382601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2G2"/>
    <dbReference type="STRING" id="91928.A0A0D2B2G2"/>
    <dbReference type="GeneID" id="27335358"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08275"/>
    <dbReference type="HOGENOM" id="CLU_010001_1_0_1"/>
    <dbReference type="OrthoDB" id="3429912at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="595"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="74139" checksum="9CFB13E803CD0C5B" modified="2015-04-29" version="1">MLLPVRLKTSKPHALSADEANKRTGLEKAIFQVEQALKRSRDGSTGLALDVEADLRQLISAPQTAPLRRHSTSNAHSANGVSPNAHEVSPANMGEKPDELALNNADNPLQLLAMASVLPGQSPSTNMSTSPAGTLAHQTSVESDLADADLQQFFGSLMSNLDNTPELDPIELGLVTSEEADTLFAFFYERLSHTRWGLDPTLHTSAFVRSRSAFLFTSILAASALFLPKAEALSKRLSHHRSHLVRTVIYNKYRSVEIVLAFMVNIPWMTPAKHWADDETCKYLSAALTLALDLSLNKIVVPSPTIRPAGFLDRMAKADCIDATKALQIDGFPNVDPSSAWGRRLLRTRERVYLALFVLDRGVCLARGRPYAVPIGPLVESCDTWHISDIADRWDGSVISAAVLRRDLVGLIAGVREFCDGSQGINGGSTAVKFLKDKIDRFFEQWFAVWSRQITQGDGQLPPYVEILASHTKLSTYCNVVNHPTASNDVKQFFRAAGLASAMNVMRAAVQGENRLKSMPNNTVIMVSFAACFALALGATALGSRAMLAPNARSLIEETTQVLERIGSTPKHRNGLSVLFARHIRRILQSSLLHPAEGNPGNTMAGSEQAMHQDNPNVEYSSSSNAPVNLPNASSEPYVFDMTDDQILEAINNASASQDLFQLDETMFVDWLDWPNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2K5</accession>
    <name>A0A0D2B2K5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233364.1">
        <property type="nucleotide sequence ID" value="XM_016382661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2K5"/>
    <dbReference type="STRING" id="91928.A0A0D2B2K5"/>
    <dbReference type="GeneID" id="27335418"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08335"/>
    <dbReference type="HOGENOM" id="CLU_018012_0_1_1"/>
    <dbReference type="OrthoDB" id="4148736at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306:SF8">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="64354" checksum="BEE2F3EECE19E9C4" modified="2015-04-29" version="1">MAEKTLDSEREEGTVGIGVTWPIATPIPLLESVWRPFLSASSSSPGSYQIYKTVAMVLIIAVLLHRVVLRKQTKKYHLFPGWAALEIAVVSHLTTRGGLGRRIYTAIRRRGGGSLYGLTWTHQVLVNLPDADVDRIMAQSHHTLSAEPVQYTLFTRVFGATDSPVLKAKLEDSWRDLLGPVERMFLDDAAATAALEKGGGVFQKAAGFVSFSSNPKRMRRWELSADVRVVKPDSPGRPGAVEANLQSLARDFGACIAIPLLYGQDFLARYPGLLDGFWNFDNDLFPLLAVGVPTWLPIKVVRDGLAARSRLLKETEALYRRIDQYQQGQQVDFGADLTDISRVALDRNRNANTQSLLFWLLVYVYSTPGLCARIREEMEPYVDIAVTASTGDGNRSEITSVDASGLCRDCVLLKACVFETCRMANEATSIRYVARPFTINETDGAVTTTASATRAHKLERGMFVSVPHSLGQRDPSVYVDPDKFNPDRFLEVDQRDSNGTLVARYGRLKPWGSGAAMCKGRTFAEKQIMLAAAAIIGLWDISPAGDGGDWEVPDMMPGTGVKKPKNDVRVVITPRHSGPRLHCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B363</accession>
    <name>A0A0D2B363_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation machinery-associated protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMA20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233236.1">
        <property type="nucleotide sequence ID" value="XM_016382533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B363"/>
    <dbReference type="STRING" id="91928.A0A0D2B363"/>
    <dbReference type="GeneID" id="27335290"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08207"/>
    <dbReference type="HOGENOM" id="CLU_090468_0_1_1"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="90"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="181" mass="19890" checksum="CAB8DD7F4AD701A2" modified="2015-04-29" version="1">MFKKDLSAGAKSKVKSSVQRGIRAKVLETYPKLEPHIEEIMPKKSQLDLVKLPDRVSLYVLDDRPLFYQHMDDPIIPHLKIVHQYPHAFKTIGIDRGAIRFVLSGATLMVPGLTSPGGRLPDADEEAKAGDIVAIAAEGKTEICLIGQLEMGTEEMKKAKKGVAMAAGHYLGDGLWKMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B448</accession>
    <name>A0A0D2B448_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233949.1">
        <property type="nucleotide sequence ID" value="XM_016383246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B448"/>
    <dbReference type="STRING" id="91928.A0A0D2B448"/>
    <dbReference type="GeneID" id="27336007"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08924"/>
    <dbReference type="HOGENOM" id="CLU_110345_1_0_1"/>
    <dbReference type="OrthoDB" id="4776947at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249455" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="16678" checksum="4731C8139ABF4349" modified="2015-04-29" version="1">MKASLVLPTLLALFGTRTLAATPPGCLLSAVNTQDNPTDLSSICGDEATEVQSAINSLCSGSTNKSAAQSAFIATCSAAGSSVAPFTATATATATTTNGPSSSGSFVYTTVISGSTVVTSGASAPTDSSATTTGSSASSTNAEGASATGNAASDPRQVGSFAAAVIAIAGVVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B583</accession>
    <name>A0A0D2B583_9EURO</name>
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        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234254.1">
        <property type="nucleotide sequence ID" value="XM_016381152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B583"/>
    <dbReference type="STRING" id="91928.A0A0D2B583"/>
    <dbReference type="GeneID" id="27333902"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06819"/>
    <dbReference type="HOGENOM" id="CLU_012062_0_0_1"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12330">
        <property type="entry name" value="RRM2_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="117"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW14038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="478" mass="52693" checksum="556B7809BA4AF3F0" modified="2015-04-29" version="1">MFIGGLNWETTDQSLHDYFSQFGEVQECTVMRDSATGRSRGFGFLTFKDPKTVNTVMVKEHFLDGKIVRFIPKSPKGGQEKPGSPCQKIPPKDRRLRSPFQIDPKRAIPRDEQEKTAKIFVGGVSQDATEEDFESFFAQFGRVVDATLMMDKDTGRPRGFGFVTFDSDTAVEKCLEYQPLEILGKPIEVKRAQPRGKMGEDDDFSRRGRGKFGRDDRFGGNDGNNASQPSQSAAPNMMGNNSGMTPQMMAQYWQRMQQYFAMMQQQMVTNMMGNMGNMGNMGMNQMNPQMMQQMMQMQKMQGGNSPNSQNSNMNMQGMTPQMMQQMMQMQQQQQQGGMNPMQMGGGNRPPMGPSSMGAGGQRGSFSAQEQLAFEQQKYEHQSNRRGGGGYPQGPRNQNFQGGGPQSWEGMYDDVPQPDAGRNSAGPVRGHTPKPPKGPAGGGVGQPSAPANAPTGPKNPGKPGGGFRGGRGRYHPYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5I8</accession>
    <name>A0A0D2B5I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234404.1">
        <property type="nucleotide sequence ID" value="XM_016381302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5I8"/>
    <dbReference type="STRING" id="91928.A0A0D2B5I8"/>
    <dbReference type="GeneID" id="27334052"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06969"/>
    <dbReference type="HOGENOM" id="CLU_013199_0_0_1"/>
    <dbReference type="OrthoDB" id="5333304at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="796" mass="88930" checksum="8FC6E9D6F4F931C2" modified="2015-04-29" version="1">MSASAAPLLNGAIPGPMGAFNEASEFQKILRIRDQVFSGDHPRLTVPAHSIRLSSSQTPSTVSQSLLNVPPPLPSSVSPNRLAGISSRQEETTKANGVASNVSEFDPILLTKSDDLVRAEIQLKRQRLERTLKEQFEQKRQDARRKPAPSEAKPDFDLPAVLAKVLKTPKSPTTKDEGEASDSFDANSLYSSRAPDSTPEGPNSGDESDDVQADEPPRPPAVSAVMGEPLPQDDERPASTNVQPVPQPIAATSAIEVDDEEEEGEYSPPEATAFPVAKIASSQPMPDDRDPRGRPLRRYSETEDNGRRPLSPSEANMRIVRNQITSPVAPVPSRVSPLAVAKDPPFLQNGRQKQSQIGRPGSPPSPDESQGNIPPRKRRKLERRAEKRARQNGGYAPHVKEENISPPPFHDVQPLGSGRLRPIGADRPIVIEEDPMQDAHYMPPPERYVDSPARPIHRQVEQLMPLSEPRAMSRASLRPMREDQDLRRVASMHNMRAEGPREYTDPYYESPARTRAVSYARAGTPAAYESPRYQREPLEEYDRPHQEVRVVRTPAPVYREIYDDAEPYRYTAEPMPPPRMVERIVVDSYGRRFREIIEERPPAFSRAVSVRRNDVEPSYDGYRNTRAGSVFVEPPPERNFSTADMPPPPPSYRRGGETLRSSVAAAPPSREFAEPGSLPRSASVMMNHSPRHAMYPDERPGFREPIRMGSVRPPAMRYEEAPAAQLMARSQSVRPGIREGSYFPHDRPPVSHEYATSEQSRYHAPESDPRHYDAQGREIIPMDGPMDMRPRGVDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B629</accession>
    <name>A0A0D2B629_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234361.1">
        <property type="nucleotide sequence ID" value="XM_016381259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B629"/>
    <dbReference type="STRING" id="91928.A0A0D2B629"/>
    <dbReference type="GeneID" id="27334009"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06926"/>
    <dbReference type="HOGENOM" id="CLU_003953_5_2_1"/>
    <dbReference type="OrthoDB" id="5135333at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="220"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="876" mass="100083" checksum="5BF4982AB5D243D4" modified="2015-04-29" version="1">MQKLLSSLRRHRNRKVDSSRTSKWFHLRRQRPDPPTPLTTFISPPSVITSIWSEWAQELDSPDPNLCTRCAGLKLTAAHFRLSAEEVKETANPSNIDDPITIDTREWQHIDAAKNCGLCQMIKRAVELSRLEWQSSESPNTCEIKLTLLPGHPAKTHNVRRLEIAVHYDWTSSHDISLLPVESHRCRHEETPQFRRIRDQIIVIDLEDQCLVVLPPNARYIALSYVWGQVEQPKTSKDNMESFLVILDAMEFVKMLGERYLWLDTLCIIQDDADFKEKLLNSMHTVYENAYLTLFAATGADSNAGLPGVQPSSRGALQLVTNISDGLKLVLPISYQRIKRSTWATRAWTYQEYFFAKRRLLFVDGQVVYQCNTGEWAGSRMGWEPPVLHKAVGLSVDYWTRFDFNRYVETYLDRNLSFEEDILSAFTGIIKEAEEKQLKICWGLIEKYMGLDMLWMPCKWLVRRPGFPSWCWAGWKGAVICYRESKWSTEETWLHRTSWIDWYIYRNALGKFQLLSSGYAPQQETVIAQEEELRRRLDERYQETLRTEREHDKDIVGQSGPERQTAPETGALASLLWRLCQSNSGNNAASSSREPPWPMYSCKPTINEQTLLFRTLTAYVSISSLNPRGQMSLPPRDDRLLLPSAPTLHLYAPDGTHIGAAWSHTQEFFETVRKYDKDITTLDPSAGAPRLKIEVALMAGPVEGDWRSRSERHTTWEYMLELAKAGLNLGMVSARYDKRLSYERVIAETYINMVSDRGAFVEGVERHLAASFWDELEMVIQSMHLENLYPQHCEETLRPVIDGLKTEKGGMRSKEGQKFVKVMLVGPLGDGEMVSSSGSGSSSSTGGVKERVGIGEIRDDAIGLIQGLAVRDVTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B728</accession>
    <name>A0A0D2B728_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_07527</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234959.1">
        <property type="nucleotide sequence ID" value="XM_016381857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B728"/>
    <dbReference type="STRING" id="91928.A0A0D2B728"/>
    <dbReference type="GeneID" id="27334610"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07527"/>
    <dbReference type="HOGENOM" id="CLU_089407_0_0_1"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW14743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="282" mass="31110" checksum="7704A745F8EA8CFD" modified="2015-04-29" version="1">MAFQARAFQQACRLRSQPATSMMRLENPQANANTNATTSILTTSRPYTSQHTRTRSRPQTRSPPLALSLSLPGQARRHTRRASSSASSSSSSSTTPRRSITVTSDDGRYNWSDLSTSEKAARGTQQTFNFLLVAAGLVGTVTISYLLYQELLSPDSSAIQFNAAVSRIKSSPECRALLGPSREITAFGEPTANKWARARPLAHSTETDRYGTTHFRMHFNVAGPEGEGVVTVHMTKPRGGDRLEYQLLSLTVKGHETVYLENKEAERNVKSKVGKMFGVQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9H4</accession>
    <name>A0A0D2B9H4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235804.1">
        <property type="nucleotide sequence ID" value="XM_016379977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9H4"/>
    <dbReference type="STRING" id="91928.A0A0D2B9H4"/>
    <dbReference type="GeneID" id="27332719"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05636"/>
    <dbReference type="HOGENOM" id="CLU_007899_0_0_1"/>
    <dbReference type="OrthoDB" id="3199516at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="43"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="875" mass="98244" checksum="1C33863FE17F259A" modified="2015-04-29" version="1">MESSLEGDEGSQKMKRAGHHTLLAKHLQGKKPEWDAISSQKQPLRLLDLPVDILQAILRELTHTNDLTSLALTHSALHALVIPHIYSRFDIVWPDANATFENRMGVDALTYGLATLVMTQDVFGEAPYQQQPLYQCQQCGHHNHPSPSNPSGPRKIRRGNYFAQYTKKFSLGNGPSDWVQEYLITKEGGKMLGTLVALAVGRMRNLEAFIWDMPTGVLRDVWLALASLGNRDDGQECRLDRIWVRWHDNQDQGPLASPPLPGAGPGVHVSNLPSILAGTANALFQIPPYPRVEFPTFSILPPLRSLSVLDIDELPYAEEMSVLIERSLDKMEELRVGMAPHAQYDIWARPTDNRAPVLQPLMSSPSDQTPRPGGILGILVHRFCDPFVQDRSKEFTSGHETQEYLIPEVDESQNPEYGEEGKDDSVDQSQAEDVEHLGALLLAQNLQDEELEPAAKATTCPGQLHVPKQNHLRKVSESFNDPHQEERSFRKLRLNTLELERIYLSITVLSKAIDWSRLRTLTLLGCRNHEQIWKALRKQFTPTSRRRVSSTGFRTSGNSSSKVADETASSSLEPAPSDYPLGLKRLHTDTVSPSLIAFIKDTLAPDSLEWLFLQANPTYKSQVSIDMIYRGAIRRHRGSLRKLLIDSTLRTEDPDPPDTWRRWVLNRELITCITSGKMKLRELSMSIDYKDWHHFLRRLPNATTLRSLHISHIAEHVNGTVHSRDAALQVLDIVALRPELELCYLGIQTHCYEILEYASTRKGPVFTGLNGSGSGGHSGEDLDTDQDAGPAGGDAHSAQQGHHHSHRFSQDDDDDDGDMDDTSDFEVVSDSDEAMTDEEGAQGADSNMPKPTWRLREILFYDDKISIFKARHGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9Z5</accession>
    <name>A0A0D2B9Z5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235651.1">
        <property type="nucleotide sequence ID" value="XM_016379824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9Z5"/>
    <dbReference type="STRING" id="91928.A0A0D2B9Z5"/>
    <dbReference type="GeneID" id="27332564"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05481"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_2_1"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="115" mass="12047" checksum="14D78D7DD3EA04C7" modified="2015-04-29" version="1">MSGVAAGPYSQAIKAAGLVFAAGQIPADSTGKLVSGSIAEKTEQCCKNLKAILEAAGSGIPKVVKVGVFLSDMKHFPEMNGEYEKWFSHKPARTCVAARELPKGVDVEIEAIAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBQ7</accession>
    <name>A0A0D2BBQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236659.1">
        <property type="nucleotide sequence ID" value="XM_016380832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBQ7"/>
    <dbReference type="STRING" id="91928.A0A0D2BBQ7"/>
    <dbReference type="GeneID" id="27333579"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06496"/>
    <dbReference type="HOGENOM" id="CLU_297352_0_0_1"/>
    <dbReference type="OrthoDB" id="5389734at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1010" mass="109568" checksum="387834B497CE60C2" modified="2015-04-29" version="1">MSIDKADHGGETLVRPPTHPVPQLQKPFEESMVESVDDLADHELPMDAMTRRTVLLEGKSYERVIAGRWRQKQGEKYHPLWKLIAQMSFGMHLLAKSMAISEEEVMRILQSHVDDIDGFLERTTEDFDLAQSDIHERIRCLKLPLSHGEVFDRMLEDRTFRASILDGNEKIEHVISRTKRATKDALKDVQKGFDATNVLEKYLSKLNSTWKRDSSEHEAVLVAMLGNAEGWRRAFLELHLQGNKLIGSLKKLAEVVAEMERRAAIVSRNLVVSVFVLDFKPCADKQEARAQKSRHISFQKKSHTLSQMGSIASQKPLPTEPGRHHGSKNSSHSTQLSGLSSRPDSRHDSSRGATSHSSLGPGSRPSTASKRPVKHELHNQSLIGANSTNESLAAKDDDIRRSLNGYVKQAGDIHPIELPADVPENVLRQAPVSIKNRLSMTLGLKPKDYSDHRISSIYYPRALGDLLKTRPMSGLLLTPQSMSAKGTAVHAVSSPAAMSYAETDYYSSHERSPSIGVVTPDNSSGKETNFNKASPRATRSSTLGSVAASASVTRRSSIPNLAFTSHSAVMAMADPPSELPAESPREESIAPSEVRKLSQSQPSSLGEPGPEFTDGATNRTRSASDPVLLVDTSVVSISVVPASAEEETFAAAGQQAQNSTSQEEESSNNRTEAETATAVSDTPDQADVAHTPAHLSDNDMEKIGADGQVVPLATAPEEAEGSQRQFVAELEAAVPRSSVVPIHKDIGPAELEAAPQQTFRLPPRPTATTKNPEKEVPRASIHNLEDFFKLPSAMTLEPGTKTKNFGSVNFQEPIGPLKLELAKRDGKIVPVRVSDRTVNDTAESASNLRLMTVADIIETMSHTPPGSPIHARSNSWASTNSAQRLSHRSSQSLGPPAQARPPPAPGGRSMVDPDFASAGQFDGERKQRKKSTIGGKSGWKTFFSGGGAAAVERPSISIAASTTVSDAPIRPRPSSEAVPRAPYMLAAAGKEVPWFKGTIKRKSRKGNSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBT5</accession>
    <name>A0A0D2BBT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236281.1">
        <property type="nucleotide sequence ID" value="XM_016380454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBT5"/>
    <dbReference type="STRING" id="91928.A0A0D2BBT5"/>
    <dbReference type="GeneID" id="27333199"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06116"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_4_1"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="65"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="403" mass="44158" checksum="2D335A156F25663F" modified="2015-04-29" version="1">MALLPTFELPKYIRETEDRVKYGLGGSATPYMSIADLISLSSDPDTTAKNLDVRSLKLGGGMGLGSPGVRAAIANLYKGISPDQVMTAVGTTGANAMVFTTLLSSGDHVISLFPTYGQLSGQPKGFPCEVSSWNLDISDGWKLHVDQLEALIRPNTKMIVLNNPNNPTGTYLDADTQKQILDVARKHDIIVMVDEIFRPLYHEDDNGNIAGSPSFVEHDDHYTGRGVVVTSSMSKVWGLTGARIGWIVTKDQEILSKILDVKFYAFTSTSDIDEVVAAEALSDRCRPNILKKHLGNARANLPLLDAFVKKNSDMVSWTKPTAAATAFIRLSWKGTPIDDVEFCKALLDEEGVLLSPGSLCFGEDRQKELLGFVRCHFTFQPEKMAPALEAWDRFLQKTRASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BC64</accession>
    <name>A0A0D2BC64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236764.1">
        <property type="nucleotide sequence ID" value="XM_016378087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BC64"/>
    <dbReference type="STRING" id="91928.A0A0D2BC64"/>
    <dbReference type="GeneID" id="27330819"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03736"/>
    <dbReference type="HOGENOM" id="CLU_007884_0_1_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="456" mass="50681" checksum="75365228F3A85165" modified="2015-04-29" version="1">MRDNKPTPGEILIIGGGVFGISTAVALLERPQYRNTRINIVDTSSELPNQSAASWDTSRMLRADYAEAAYTKLVSEARKQWTNSDSNAWGGEGRYYDAPLLLTAQPGVLGHVDGYLERSLENLQKLAETRDFAFMPEDVKELADEDAIRAASGPIPGVSGNVGYINRNCGWVDARGCLRFLYQKLRHASKGKCKIHYGTTVCKLLYEGIAGSSINPARCIGAKTTNGSRIHADLTILAAGAWSPSLVDMQGRAEATGQILGYLTLTEEEQASLNNMPIYFNMSTGMFMFPAHNHELKLGRHGFGYQNPTPVILEGKRKLISTPISHLPVPTEAEDALRDFLVELFPHWRNKELSKTKLCWYCDTPNGDFLIDYHPDYKGLFLATGDSGHGVKVLPVIGEKIADSIEGKLDHTLQELWRWREDITAVFQGTSDGTRGGRRGMVFQEEWQKSKIRQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDX4</accession>
    <name>A0A0D2BDX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237379.1">
        <property type="nucleotide sequence ID" value="XM_016378702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDX4"/>
    <dbReference type="STRING" id="91928.A0A0D2BDX4"/>
    <dbReference type="GeneID" id="27331437"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04354"/>
    <dbReference type="HOGENOM" id="CLU_014001_4_1_1"/>
    <dbReference type="OrthoDB" id="30289at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF3">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="121"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="559" mass="61813" checksum="2A77F4CFC599A8FB" modified="2015-04-29" version="1">MSQLYRTLTGQSHQSHRSDHSTQAQSTVTRTTTTDPLTGTLNHLTAAQEERLVEFKKELQVGGWWTPDGVNGKPSHDDATLLRYLRARKFDVKGAIGQFTDTEKWLKDQRVDELYNHFDVETYEKARLMYPQWTGHRDKRGIPIYVYVIKGLDGKNVSKYQKESQTYKDSLPYHKNLPTPAKLIPLFALYQNLLNFVLPLVCTLERPNPEVPVTNSTNIVDISGVGLTQFWNLKNHMQDASILATAHYPETLDRIFIIGAPSFFPTVWGWVKRWFDPVTVSKIFILGKNDIKPTLSKFMETKDFPKRYGGDLDWEWGQLPHLDDETRAALEKDGNKGWVRGPCQWLDGKRVVVGSEHGKLRTPDEEVEKKRPVAYAADYTELPVHAGKGLSHVSTLTAKSGTNGTAEPHREAEAEAAAATGGTTAAALIESKTETKEPEQPSTTGQPAEQPTTNGTPESSPSQPQPGPVPAHAAAMTQAIADKLSGESVSIIPATANGVATKGDNTGHGEVIVASDPAKGLTIEAERLALTDQNGHRGDEKEKEIERPPMERFVTAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE07</accession>
    <name>A0A0D2BE07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237419.1">
        <property type="nucleotide sequence ID" value="XM_016378742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE07"/>
    <dbReference type="STRING" id="91928.A0A0D2BE07"/>
    <dbReference type="GeneID" id="27331477"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04394"/>
    <dbReference type="HOGENOM" id="CLU_112958_0_1_1"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="145" mass="16682" checksum="DF263EB92DA73BBB" modified="2015-04-29" version="1">MGRVRTKTVKKSAKVIIERYYPKLTLDFETNKRICDEIAIIPSKRLRNKIAGYTTHLMKRIQRGPVRGISFKLQEEERERKDQYVPEISALDFTQNTESGQLDVDSDTKDLLKSMGFDSIPVNVVPVVQQQQQERGGRRVFGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE40</accession>
    <name>A0A0D2BE40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237464.1">
        <property type="nucleotide sequence ID" value="XM_016378787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE40"/>
    <dbReference type="GeneID" id="27331522"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04439"/>
    <dbReference type="HOGENOM" id="CLU_082453_1_0_1"/>
    <dbReference type="OrthoDB" id="4932428at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="197" mass="22428" checksum="FD596C5A57226DE6" modified="2015-04-29" version="1">MSRQTSGSAGRSQHYQLVSPGTPADPRTMSQVSPGFVFNNKDQLIESLRTHRVNTITELRRIEKIFAYLDSAEVTEPMTTAWAHYVNSNNLLNELRGLTRRYPFSSECLDEAKSMVVRDPNSVRSWNYCWLVLVKMERENLVTKHARALASKASTWGGRRPSAAEFDRLVSACVAEWTQALRQMLRHWDKPPSTTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEB3</accession>
    <name>A0A0D2BEB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_04120</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237146.1">
        <property type="nucleotide sequence ID" value="XM_016378469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEB3"/>
    <dbReference type="STRING" id="91928.A0A0D2BEB3"/>
    <dbReference type="GeneID" id="27331203"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04120"/>
    <dbReference type="HOGENOM" id="CLU_145518_1_0_1"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW16930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9844" checksum="98DA86EB42C82F65" modified="2015-04-29" version="1">MAPPTNPTGFNMKTFTDAATSPQWRAKDPWAKNEAWRYTGPFTRWNRFKGAFPGFGIAVVAFTGYVIFEQLFLKDSHGHAEAHGEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEH5</accession>
    <name>A0A0D2BEH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237604.1">
        <property type="nucleotide sequence ID" value="XM_016378927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEH5"/>
    <dbReference type="STRING" id="91928.A0A0D2BEH5"/>
    <dbReference type="GeneID" id="27331665"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04582"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="375" mass="39500" checksum="AE3814DAD403A25D" modified="2015-04-29" version="1">MAGPPPSSALDSAGPDAAAATAAANKDKIVLVTGINGYIAGHIGLQLLQKGYTVRGTSRSSTAHAHLLSGAFEGYESQYEHVVVPDITAAGAFDSAVRGVHAIIHTASPVDFSLTTLEAFYGPAVGGNLSILDSALAHASSTLKSFVVTSSVAAVVDRWKQPPGHAYTEADWNTSGEAVARETFSPGVAYGASKAAAERAVWDWTSAHKPPFAVAAINPSVVTGPPASFPKTPEALNETLLPVWRIWSGDKTVPAQIGSAGYIDVRDVARLHVWAMEHPARSDGQRYLVANGKAPPQAAADLLRERFPDRDIVVGNPGEGYTPDYAFVDGEPSMVSTKALDALGVDGFISYDRSILDTVDAFEKQWPGHAKNFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF98</accession>
    <name>A0A0D2BF98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237511.1">
        <property type="nucleotide sequence ID" value="XM_016378834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BF98"/>
    <dbReference type="STRING" id="91928.A0A0D2BF98"/>
    <dbReference type="GeneID" id="27331569"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04486"/>
    <dbReference type="HOGENOM" id="CLU_003431_1_0_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF2">
        <property type="entry name" value="HELICASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1089" mass="121562" checksum="A2344CAF67D1E098" modified="2015-04-29" version="1">MTLLSRKSSSDSTGKGNDARGRTRASSTERDQGSSKSSLLRRLSKSISRSDEGPKKTDEHSETAQHHEAKTSQKQPSTDAKQKVIEPKVDELKPKTTALDVRVEPVESHPHHSVHAVSPRSPPSKPTSATDNHDLPIQDSDMVSHTATKQEHSKKLKGLTKDDVEHLFNGAPHFILEKGTRGRFFPQAFFPWNNDLEVGDLQDRRYLKHESFAFCTLHAHLPIPDEVGWVPGMPFPMKKAGLETGKRPLFELGIYERPNMLAQDGREPGTVGLRYFLERPVADGVQDSKIREHTKDVEVDLAMSDTTATEAFKMLALSRDNEEMNAKVGKHAPVQDRLKIINGGPPAWRNVGVRPITMQCLVGRMEVLDGWRDRTISAGWRATVLDQVKSLELHEHLFGELLFPPRKLPDASKWHDKEAMKVQIEALVKVLATPGAWLDLSDPEARLRFGKIINSRTTHFDPTTGTMIINPERKWLLIQLLLSLELVVRLDAALRLGIAMHAEKFEISSEEIHHFNKLRTLKVDWDLVLARRYMDFCHVKRNEHKETLIKTESGTHKLDRHSSFFSGLRHSLGLDDRAESEPDVCDVAILPRDPQIIVDGVFRFATNIGWPRALDVQSRISQKLNQGTQEERERFLLEAFFCSNEAHHAQHESTQNIVPPLNHFNLNLHAASPDTIGGWLSHSWFSGLILPGHSICDILMATLLENDTDPATLEALGTMNLPFRSCGFVLGGSSWWSKSSIVSRVLAPLRGSKESMGWTYLPNFVPFVEATSEPVLNRWLKIKSYPVPTQRERPRIFDGDRLATESTPLGVGKGGIMGAEFSMVTDHIFDYDSHAEVVVNEVSLHLSNTNATSVSADHALSAWTQFDLTITRAGGTKEAKKVRYGLDRAVYFVTAHPCRLPHGHATLKAGSGDDDHDPQHPQHKPAEHIPAHPLHKTYKFVTKSLEEVVQTPHLEPPASGVSSAEVWIVDARHPLGDDERETWSQLQSLFARSRNQNQGQNQAENKGSSEDKSSNHGSASSKSLVSSLSDWCGPGVEQIRNKDVLVRAWCAQKGRNAIIARVGRTCLSCAVREAKALEIGVVVRVGIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFI1</accession>
    <name>A0A0D2BFI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230315.1">
        <property type="nucleotide sequence ID" value="XM_016385371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFI1"/>
    <dbReference type="STRING" id="91928.A0A0D2BFI1"/>
    <dbReference type="GeneID" id="27338142"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11059"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_9_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF96">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239077" description="Cytochrome P450" evidence="3">
        <location>
            <begin position="25"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24039" checksum="D61AF06EFABC6DB9" modified="2015-04-29" version="1">MNTETKLLIMGVVLLLVLVRVLSAIRASSNGPLNKIPGPTIARWTNLRLKWAIITGQRIFYVHELHQRYGPFVRISPTEIAVSDVESFTQIHRIGSGFHKSRWYLDLVDFPRPTLFSMNDPAAHAARRRLLARGFSKSSLRQRWESVVNDRILLTMRKIGEESTAEGHADVLKWFTFMATDISSHLMFGNSQDMVNLGKAGDFLSSFTPERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGG8</accession>
    <name>A0A0D2BGG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="15" type="ORF">PV08_04930</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237951.1">
        <property type="nucleotide sequence ID" value="XM_016379274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGG8"/>
    <dbReference type="STRING" id="91928.A0A0D2BGG8"/>
    <dbReference type="GeneID" id="27332013"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04930"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="391"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="796"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW17735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="815" mass="91065" checksum="EC792EBCBA920034" modified="2015-04-29" version="1">MALLQHKALADYAKQLDAFESFLKKFETSKTSSDAAAEAIDSLHLDGDHTSDEYDFMDDITDDSNSRRRPKRKYMEMLQEVADRERQNILVELDDLQEFEDSLPGDISLRLVESVTNNTKHYVDLFSEAVDKVIPKASKDISFKDDVLDIIMAQRAKRNETVAAANEADSDAALPVSTFPPELTRRYTLNFKPLTSSASERAKKTLAVRQVRGEHLGHLITVRGITTRVSDVKPSIRIQAYTCDRCGCEIFQPITSKNFTPLQLCPSDECKANDSKGQLFPSTRASKFLPFQEVKIQEMADQVPVGHIPRTLTVHCNGSLARQLNPGDVVDIDGIFLPTPYTGFRAIRAGLLTDTYLEAQNITQHKKAYQDLKMDPRIIRRIESFKATGHMYEYLARSIAPEIYGHLDVKKALLLLLIGGVTKTMGDGMRIRGDINICLMGDPGVAKSQLLKYITKVAPRGVYTTGRGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMDDGDRTAIHEVMEQQTISISKAGITTTLNARTSILAAANPLYGRYNPRISPVDNINLPAALLSRFDVLFLILDTPSREADEELANHVCYVHMHNSHPEREGEGVVFAPHEVRQYIAQARTFRPNVPKSVSDYMVGAYVRMRQQQKREEGSKKQFTHTSPRTLLGVLRLSQALARLRFSEEVVNEDVDEALRLIEVSKASLYHDQRAQGDQTVSSRIYDLIRGMRESGAASVSRGARGELNMRRVTELILAKGFTQDQLTRTVEEYELLDVWQLANNGARLVWIEAGDSDDEDDDDENMDDGDHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGM2</accession>
    <name>A0A0D2BGM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
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            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016385741.1"/>
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    <dbReference type="OrthoDB" id="5398515at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
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    </dbReference>
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        </location>
    </feature>
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        <location>
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        </location>
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            <end position="430"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
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        </location>
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        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
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            <begin position="330"/>
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            <begin position="343"/>
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        </location>
    </feature>
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            <begin position="354"/>
            <end position="366"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="430" mass="47384" checksum="7C4434961D8EF436" modified="2015-04-29" version="1">MAATPPAQIATTPETPLTPLHGAAYERFDSRRPTRSSARIASREHRSTFDASRRSPGDASLTTPKRSKKLTATSPGLHSPQSTPRPRSTRRVQVLSPPSPTVLPSSSSKHQSSRSNLQALASSSTMISDGMLPTPVKTPKKKQVSEVNGTARALFQDPAHAADGVADVEPNPRRNRKNKRYNGYSLESFSVEGEGSQGQIQIFTDSRDRVPQLDKSVSNPFVESTVDDETVSSRKIAGTAKRRKVSAEARKMDSQVKEALKKDEGMVYVFRGKKVYRRFNDDDDEEEEINPEDLEDLGLLEHTPKGTKIKPIRTLTRRSIKPTRLFQTEQEERARELEKVEEALTDIEETADVNDDHLLSGEESPTKRTRSLRSAAKGSPRSEDGINGTSRKKGSPFDTWPRVKSTAGTVSSSSTKGRKRAAAEAIDDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHY0</accession>
    <name>A0A0D2BHY0_9EURO</name>
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        </submittedName>
    </protein>
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    </gene>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
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                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
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                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
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        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
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    </dbReference>
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        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="179" mass="19532" checksum="784DFBE47B41AB23" modified="2015-04-29" version="1">MPGSGSSTPSPRSSRWSFLSSRSFALHAIPISYALAYPPHVYVLGTLMKASSSNYAFTNMVPRVNLERLGPSLPKATTDMLWRARGCHLNTLEGFPLFAAAMLAGTYTSLPTRDLNICAAEYLAARVVYNVLYMTVRSEAASYLRTAVYFYSVGIPFYVLWKAGQKAAGAIAQEKGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BI96</accession>
    <name>A0A0D2BI96_9EURO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016384688.1"/>
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    <dbReference type="GeneID" id="27337456"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="121"/>
            <end position="350"/>
        </location>
    </feature>
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            <begin position="121"/>
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            <begin position="234"/>
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        </location>
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        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="418" mass="47329" checksum="603CDB150F19621C" modified="2015-04-29" version="1">MCLYNFFPCISHDAQALHKTLFEEINASFAVQAFRCKWYHCANLRFNGGSKLCPYLIIRHQTKKPPIEELSRTYRAVLENEVLDHGCGKCWDTVRKKGWVQSVHTQMANNLNMMPVAWAETHSDREEEQSSHYEQSSAEEGCESLVTESEGESKGKRKRRCSEVSIPPPPWNKKSKKVCMSDVGASPSGSSETDSEQESDEDEEEEGSEDGKVESDLDQEDKDYIRACQESLESFERENNRRGKGKGKEKEIIQVSTRDDGDDGDGDDDEAADPDLQRALQASLEEQEAPKNKNFWRHRPDVDRHMRFGSGGESSSSKKDVAVAPQQPLITPPNSQKSPSNSEEDTRPNQSYGFDVVALLKEKVAWQKEKAALISENARLLQTNMAHVERGIELERRNRELEELCFPTDDHTDAAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIA1</accession>
    <name>A0A0D2BIA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016377339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIA1"/>
    <dbReference type="STRING" id="91928.A0A0D2BIA1"/>
    <dbReference type="GeneID" id="27330065"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02982"/>
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    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60465" checksum="12A952973EB6D47A" modified="2015-04-29" version="1">MDIDHVRDEKSNTGSVPHNNKHEARVMNASEDPILQPSSPNTKKTMDFSDEKPTVSTAENVNHGDADGDSHNAAVDIDKRRYDPTLAPRYTQEEEDAVIRKLDWHLMPLIFVLYSLSVLDRSNLGNARIAGMEDDIDLSGNRYDWLGTAFYISYILSQWTQVGWKAFPPHRWVAFAVFGWGTVSTLQAACSSWAGVMVCRVLLAIFEASFGPGVPGYLSYFYPREKLGLRTGIFLSGSAAANAYGSALAYGIAQAKGSIGPWRILFIVEGVPTCLLAIVAWFWLPDSPHDVRFLSEREKEIAIDLSLRQPGDRTGRKGLQWKQVLGGLVDYRSYLPPLMYFGCNVCFASLPLFVPTIISEMGAFSRIQSNGLSAPPYVFCFVAICSSAWFSDRIRYRGPFVVVPALLAATGYVVLGTTTGVAPRYFGLFLAVLIFVSVAMVLTWVGNTHATETKRFVALAILSTGGQCGPVLGTNVFPKSEGPYYRKGMWVSCGACLLVVVTACMQMALLARENKRRDAKYGTDRETVHLQEPDEYGNDKHFRYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ05</accession>
    <name>A0A0D2BJ05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238756.1">
        <property type="nucleotide sequence ID" value="XM_016377186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ05"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ05"/>
    <dbReference type="GeneID" id="27329911"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02828"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW18540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="459" mass="51523" checksum="8ACCAEA0D7B6602D" modified="2015-04-29" version="1">MPPLHVGIVGGGLGGMATACAVAKAGLKVTVLEQAEEVKEIGAGIQMTPNVSRFLIRWGVDQVLGNSLVEFDELNLRKKDGTLIGHLKVKDTVRRQFGFPWWTVHRMHLLWGFAEVAESEGVETVLGTRIEKIDWTSSEKVKVTSTTGKQWEFDLVIGADGVNSAIRKNIMPEVKPKPPNGNCAYRATVPYDQIRQDPVSKELVKKVTMEVWMAPKSYIISYPMSAATIFNMVLSHHVDHLVEQTEDIDMEVDFRQRYADYDPRIKRVVDMVPEARRWPLLVTGPLKSWSTPQKNVVLLGDAAHSMVNHMAQGAATAIEDGAFLAKTLSKVVDGKLSLAEAIKIYEDTRMDKVAAKQRVSYLNGFMWQIPEGELTEARNKAMSAELRDEFAKYSSNLWKDPDTTSAVYGYDAERDADMAIDAYITKSQFNGDVTQHEVDKYIGWWWPAGRKNELQYSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ58</accession>
    <name>A0A0D2BJ58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231600.1">
        <property type="nucleotide sequence ID" value="XM_016384998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ58"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ58"/>
    <dbReference type="GeneID" id="27337767"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10684"/>
    <dbReference type="HOGENOM" id="CLU_044153_2_0_1"/>
    <dbReference type="OrthoDB" id="4150551at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF21">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="70"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="379" mass="42376" checksum="C27805193D5F9EAC" modified="2015-04-29" version="1">MGSLGEFNEYRGGRDSEASVLGPDSPLEVFEIPSSRNVHGNSFPLGIRPKPGYEFHTIDEAVLAIETLSKKGAFNKLLRNHGALLLRGLPTKTAADFAKAVKAFRLPQQHREIGLAGKRTSVNDTVKTANEEPPDVKFYYHSEYGRSAHFPGVLFFFSEIVPQQGGQTPLLSSLELYDRLKAELPDFLHNLTTKGIIGRQYFPAKEDPEAEHIGWNWKDSYGFDIQEGDSQEVQRAKVERVLKNNLQADAQWQDNGALHVLQRLPAIRRVESTGKPSFFNGFAGVYGRARDTNGLEPPYKGSDNKYHLPTTYGDGSPIPTAYLDRLLEISDDIGFLVPWEAGDIAMIDNYTVQHARSPWVGKRSLLVSLWDGVEKFVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJU2</accession>
    <name>A0A0D2BJU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239404.1">
        <property type="nucleotide sequence ID" value="XM_016377834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJU2"/>
    <dbReference type="GeneID" id="27330565"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03482"/>
    <dbReference type="HOGENOM" id="CLU_374690_0_0_1"/>
    <dbReference type="OrthoDB" id="4121297at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="743" mass="83029" checksum="7E1B3B18A13A254A" modified="2015-04-29" version="1">MAPKKAAKKPSVAADNAVTPTQRRDRLDAFVRRLSPHVVDNNILEFYLRSNDWDLETAHAEYIQDRTNHLELLRGRGDRDADDAEAQGLFNASMVIWNDNPEQERRDAAYAFNERVRRTTLNTQQLSRTEASLWLNINHWDVGLALRNLTSVAGNADGIRQMLGRRYDRMRTPLAAPKTERKKQGQDKTAEKIAEDKRQEQRDERLAEFINITGRPDWYSLLTFLADRDYDLVQAVQDWYTDGVPPFSGTTKRENGGMRDGPDGKRLPKPRPQDCVPRSTMPKKKQVNIPNDDDDSSSSSSSSSSGSDESEGEDNFGDDLDRFLSDSDAGSSTGSSPAPSSSTPSKQQRERVQGFIIDDYADAAKASAPNPHRYLLEYIAKGKYHSNVFEKRASHWWPDRGQADPGANSGRVVFDWDLQKHVNGLNAWWRQNRSRVADEKKRAASQKWSQEENDFLYALNLELLDQLKQKHPTKTEDQLVPLVVPTKTKEEWAKRINEKFVGRLMPGSTEPRRPRESAALMTQRGRCPAIIEKFKVPKDKVYAASAKRAEEKRAEKGKAKDTKKQDEGKTQQSQTQSQKGKGKGKAVDADGDSAMSGVESLSSSSSGGETARPPASRSPTPPESTPSRSERSTSPVDLEALQAAAMSIVNDANGRVTERLANAGINPQDSGFAETLRDGLIEEIEDLFADGGMDPMLRDSARAFIETQYQQTVNQPSRKRTASPDSSSDDGQPGPSRDPKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKI3</accession>
    <name>A0A0D2BKI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L34-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239286.1">
        <property type="nucleotide sequence ID" value="XM_016377716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKI3"/>
    <dbReference type="STRING" id="91928.A0A0D2BKI3"/>
    <dbReference type="GeneID" id="27330443"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03360"/>
    <dbReference type="HOGENOM" id="CLU_118652_1_1_1"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="116" mass="13146" checksum="181A2FB756605839" modified="2015-04-29" version="1">MAGVRLQYRRRNPYNTTSNNVRVIKTPGGKLRLLHIKKRGTAPKCGDCGIKLPGVPALRPREYATTSRPKKTVQRAYGGSRCANCVRDRIVRAFLIEEQKIVKKVLKETQEKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLH6</accession>
    <name>A0A0D2BLH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240019.1">
        <property type="nucleotide sequence ID" value="XM_016374743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLH6"/>
    <dbReference type="GeneID" id="27327461"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00378"/>
    <dbReference type="HOGENOM" id="CLU_069195_0_0_1"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28711" checksum="27E6604D9E92F5AE" modified="2015-04-29" version="1">MASTTITTSPDKAFLDKFISLLSRSYLTTPLTTAFITEIDGTPATADPAEVITPQRLSQHFTLGITAAARSNVALIQSGDFAAAALWEPPDFCGIPPSQARRNPGPILQEWRSTARELKAKYLSLPDQGPHSWDQPAAPSQSSGAPSEDPYPADFNKDVDFETRPFYHLAMLARDPDLDPKESFAAAKACMDYYVRKAKEEGVPIYLETASEASKKEYEDLGFRVCEEVVIGKGRVNAKGWPQEGGEGVKTWAMIWDEHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNL2</accession>
    <name>A0A0D2BNL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240704.1">
        <property type="nucleotide sequence ID" value="XM_016375428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNL2"/>
    <dbReference type="STRING" id="91928.A0A0D2BNL2"/>
    <dbReference type="GeneID" id="27328146"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01063"/>
    <dbReference type="HOGENOM" id="CLU_009665_2_2_1"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="434" mass="48233" checksum="33D2739583EBE0AF" modified="2015-04-29" version="1">MTASDKPWTIIVGAGPSGLLLGLMLAKQGVSVHILEASSELDDSPRAAYYGPPAAYVLRRAGVIDEIRAEGFDPSVTSWRKLDGTVLAGLDNSYLHDYPDRIACLPLAQLDRLLYRHAVVQPTLKISFEHKVVDIGQDADKAWVDVETPGGQKRLEATYVVGCDGASSVVRRCLYGKEFPGYTWDKQIVATNVAYPFEKYGYDDANFFIHPEHWHMVARLTKNEDGSGWWRVSYGEINGLSREELIARQPMKFEAMLPGHPKPGDYELAAISPYKIHQRIVDKMRVGRFVLAADAAHLNNPFGGLGLTGGLTDIGGLYDCLIGIYEGNADESILDKYSEMRRQRFKTVTDPISTENIKRLYDQDPDKALDNDDFLKLLKSMENDREKQVEFMKGPMALSYDFTQHYKTSEGTTTETKNGVVSSVVQIPAVGADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNR2</accession>
    <name>A0A0D2BNR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_00750</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240391.1">
        <property type="nucleotide sequence ID" value="XM_016375115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNR2"/>
    <dbReference type="STRING" id="91928.A0A0D2BNR2"/>
    <dbReference type="GeneID" id="27327833"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00750"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="335"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW20175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="411" mass="45937" checksum="E8566793C54C4EDC" modified="2015-04-29" version="1">MLNKLQGQPDSYEKKSQYRLGKTLGAGTYGIVREAECGGDKVAVKIILKKSVKGNEQMVYDELKMLQTLSHPHIVKFVDWFESRDKFYIVTQLATGGELFDRICDKGKFTEKDASQTIKQVLEAVDYLHGKNIVHRDLKPENLLYLTRDPSSQLVLADFGIAKTLDSPGAVLTSMAGSFGYAAPEVMLKQGHGKAVDMWSLGVITYTLLCGYSPFRSENLADLVEECKSGRIIFHERYWKDVSKDAKDFIMSLLQPDPTRRSNSSEALKHIWLTGETASEHDLLPEIRSYLAKMKLKRGIELVKLANRIDALKIQEEEPADSSDANDIPANAQNAAGLAVKNQTRGVSPGRGLSTNEAPEKRTLSKAAKSAIFKEVVLAKVREMKDKEKTDKLVAEVTKEHERRKSFTGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP00</accession>
    <name>A0A0D2BP00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240849.1">
        <property type="nucleotide sequence ID" value="XM_016375573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP00"/>
    <dbReference type="STRING" id="91928.A0A0D2BP00"/>
    <dbReference type="GeneID" id="27328292"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01209"/>
    <dbReference type="HOGENOM" id="CLU_005049_1_1_1"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="81"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="617" mass="68540" checksum="5B1CE56AD2E343AC" modified="2015-04-29" version="1">MSRPPPNARSSVASGLAPPVPGPGYPTSAHGSAVFAHPPPPPPMSVAPTSRPPSRFEPPPLSSTLGPMPGTLERPLQGPRKRLIVTCDGTWLDADNGILRNGTKQPPSNVSRIGWAIKDTSRDGIPQIVNYQAGVGTSGGAASRAVGGATGMGLKENMREAYTYIAINWRPGDEIFLIGFSRGAFTARSVGGMIGDLGLLTRAGMPSFNEIFEDWEHRMDQRYVSRFPDTPFPNKGPFNKDYVHELVRRGLTTVNVPIKAVCCWDTVGSLGIPRIGWLESLGLQARGLHKYDFYDTRLSPCVENAFQALALDERRGPFAPAVWEKRDADRTNLVQCWFPGVHSNVGGGYDDQQLANITLAWMMSKLEPFLDFRPDFLMAQWDENKAYYKSTGQKTRWWGWGEIYNSLTGLYSLAGAKTRTPGAYYRVDPDGRTTEKRLRNTNEYIHASVRARLGLQGPGVQDRGVYDPPALRDWTFDTEHVPSNGGDGLMVVWTDRGGKGGKKAGQDKIPEARLTETELVLLRQSPRVYDYVTDLRPPNVKHEKRRSRRQDASQANGGGGMSPPLVGAVPSRRRNRMSAPPEGYPPMDTDDERTRRKQRDGRDPDRQRRRKSRRYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP53</accession>
    <name>A0A0D2BP53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240919.1">
        <property type="nucleotide sequence ID" value="XM_016375643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP53"/>
    <dbReference type="STRING" id="91928.A0A0D2BP53"/>
    <dbReference type="GeneID" id="27328363"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01280"/>
    <dbReference type="HOGENOM" id="CLU_010595_1_2_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38539" checksum="A8DFA074221C8551" modified="2015-04-29" version="1">MNEGDYPESAGDGFISAEDASVGSQDDTDSAFSDDAQSRLSSSLRSSVYNYRYENGRTYHGFRDGEYPIPNDEEEQDRLDLLHHLFKMILGGNLFITQLPPSPQRILDIGTGTGIWAVECADLFPSASVIGTDLSPIQPAWVPPNLQFYVDDAESDWVFDDVGEFDFIHARALCGGIADWPKLYAQAYRNLSPGGWLEIQDHECWLNSDDGGMARAPACTQWIHEVDRASTMFGKKLNIAHQHRQWMIDAGFQDVREVVHKIPIGPWPKDPKLKELGKLMRVQMTQSVPSFMLAYFVRILGYSREYTEVVMAQVKREFRDPTLHLYLRWHFVSGKKPEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPC4</accession>
    <name>A0A0D2BPC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241004.1">
        <property type="nucleotide sequence ID" value="XM_016375728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPC4"/>
    <dbReference type="STRING" id="91928.A0A0D2BPC4"/>
    <dbReference type="GeneID" id="27328449"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01366"/>
    <dbReference type="HOGENOM" id="CLU_1204779_0_0_1"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25526" checksum="11CCAA926C5C9F0D" modified="2015-04-29" version="1">MKQCNNITPINITNKGTYIDRERRRWITQFNIPMRDTFPDGFPMGTPTLNVQRFLTALNMTRPEYLVPALDAVYAAFWNPSASSSTRTRANASSGTTTTTTTTTTTTDDETKTEAEALKVWEPRVLADLLKRNKVVPASVVDECLSKMATGAVKAELSAKTQQAFEDGAFGLPWFQCEDVSGHKEGFWGFDHIGQVVRFLDLKKRDRNDDDDDVDGTVNGAPGGELKPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ35</accession>
    <name>A0A0D2BQ35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233460.1">
        <property type="nucleotide sequence ID" value="XM_016382757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ35"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ35"/>
    <dbReference type="GeneID" id="27335514"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08431"/>
    <dbReference type="HOGENOM" id="CLU_033860_2_0_1"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="269"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="501" mass="57825" checksum="820B01724603FCF1" modified="2015-04-29" version="1">MSDGALFKPDKDFSKDADTILPEAESLAKKDLQKGIDKILGLEKQARQASDLATTSRCLVAIVTLCKEAGDWSQMNEQVLLLSKKHGQLKQAITNMVQVVMGFLDDTPNMDTKLSVIETLRTVTEGKIFVEVERARITRILSNIKKEQGDIKAACDILCELQVETFGSMTRREKTEFILEQVALCIQNGDWTQATILSRKISTRYFARKPKKTPEQLEKEKKAAEEREKKRKAGEDIPPEEKEDDVTDLKLRYYEQQITLAKHEEKYLEVCKHYRQVLNTESVENNPEQLRAVLQRVIWFVLLAPYDNEQSDLLHRVYQDSRNSEVPKDAALLKQFTIHELMRWPMVEKQYGEHLCSTDVFSKTPDSSDPKAHTRYEALRHRVIEHNVRVVAKYYTRITFPRLTELLDLSEEETEKYISDLVTKKTVYARIDRPARVVSFEVKRGPDEVLDEWSGSMKGLLGLLERVGHLIQREEMMARIQPKEEVSKKESGKKVQEKVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQU5</accession>
    <name>A0A0D2BQU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_01958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241594.1">
        <property type="nucleotide sequence ID" value="XM_016376318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQU5"/>
    <dbReference type="STRING" id="91928.A0A0D2BQU5"/>
    <dbReference type="GeneID" id="27329041"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01958"/>
    <dbReference type="HOGENOM" id="CLU_003016_0_0_1"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="277"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1065" mass="120772" checksum="A9135818A9DDBC9F" modified="2015-04-29" version="1">MESFKEFVANQVAPEGTVSDGNKTGQPPADEATPDTKETNLEQHEVDGVGDPTPVIKVNSEDSESPAEAVPQMYPLLSNNPPDSPPLAPGKRDEEDDDDDLDISKSFNRTTSPAPSLKRNKGATVGKVGEEGVTRMHKFTLHETANYYYIVGSDLLDTAFRILKIDRTSETGELNITEDDIVYTKKETQQILSAIDEGNRATGGLKMKTSFWGLLGFIRFTAQYYMIYVTKRSQVAMIGGHYIYQIDKTDMTPLVTAASTRIKTDRHLEEARFVSILGNLDLTRSYYFSYSYDVTRTLQHNITRERQALFDGLAEPLKHDHNDMFVWNHHLLQPAKQVLKNPFDWCLSIVHGYVDQSALSIYWGRVVYVTIIARRSRFFAGARFLKRGANDLGYVANDVETEQIVSEMLTTSFHAPGPTLFANDKYTSYVQHRGSIPLYWTQDNTGVSPKPDIHLNVVDPFFSAAALHFDNLFKRYGTPIYVLNLVKSRERTPRESKLLKEYTIAVNYLNQFLPEDKQILYHAWDMSRASKSRDGDVIASLEAIAEDILPKTGFFQNGNDEKTGLKLQSGVARTNCIDCLDRTNAAQFVIAKKALGYQLQALGVIEDTSVEYDSDAINLFTHMWHDHGDTIAVQYGGSHLVNTMATYRKINQWTSHSRDMVESFKRYYNNSFMDAQRQEAYNLFLGNYVFAHDKPMLWDLTTDYYLHHSDPRSMFGKRRPSYRQWYTSEYLVSPSIPPSLWPRNLRDRPLGYFDDYWVEYYRPLAITSFKKLFSFKMHSNLRYIPINSTSSGKYDFSPFKVRTGNESDGEGHEKNAARKGVKIVAPSDDAASVAGTESVASSMPHHATLEPAPKPKPNALGPWLDAQQQLHNTLHRRQYTGIIKEPSFEVQSPSVPKIPKLPTATTSDLTNSSLLQPTKAELALQSFTSLITRSLDPQVRQEGEYQRYVRHPSNIPLVVSSDIDYSSAPLEFLEYLSKTTSDPADHKVLRHYDDDRGAVSLTMDERAEASLDEYTEYIASGAVENPLTVLHEDGEKKRYKAYRKWLKGKSLFKQRPVVGDDVDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR31</accession>
    <name>A0A0D2BR31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tho complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241121.1">
        <property type="nucleotide sequence ID" value="XM_016375845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR31"/>
    <dbReference type="STRING" id="91928.A0A0D2BR31"/>
    <dbReference type="GeneID" id="27328567"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01484"/>
    <dbReference type="HOGENOM" id="CLU_049078_1_0_1"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="100"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35483" checksum="9D2E4BC6CB14D95A" modified="2015-04-29" version="1">MATFTLLDQAEEDKLHASRLLGIEERPFKRLTKRLLAPTTPIHAFLARKSDGSEEPQENVAGETAAQHEQFLKDIQRFREDVILDFAAFESSIARIQFLRAANERERERYVAEKAKIERTAEEVRDNTSTLRVQLDEAQKTLAIRKTYDVLADKITKNAALKPRDEQHVNVEKLKAEIEELEREGQEHLQAWVERREQLEKVVSEGMKLRRIIRDEKEPEKDEDGADQEHEGDRDDDENMLGVGRREGMSNAGTPRPGDPLTPLIDPRGSNVMTPTTLPEGSGRTPRPVDEDVDMEAGPVAGEARIGDDMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR70</accession>
    <name>A0A0D2BR70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233955.1">
        <property type="nucleotide sequence ID" value="XM_016383252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR70"/>
    <dbReference type="STRING" id="91928.A0A0D2BR70"/>
    <dbReference type="GeneID" id="27336013"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08930"/>
    <dbReference type="HOGENOM" id="CLU_021711_3_0_1"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000001">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="450" mass="49663" checksum="3D5839164ED23A53" modified="2015-04-29" version="1">MTLWGQDTVRDVAESVGIINLNKDVNQALCRDVEYRISQVLQEALKFMKHARRTVLWSQDIAQALRVLDLEPLYGYETTRPLKYGEASLGPGQPLFYVEDEEMDFEKLINAPLPKVPREVSFTAHWLAVEGVQPSIPQNPTSNEGRNLELLPKGPNANPALAAMAGSDNTATKPQVKHILSKELQLYFEKVCASILDETQPEYRTAGLASLKEDPGLHQLVPYFVQFVAEKVTHNLKDLFVLTQMMLVTEALTRNEKLNLTPYVASMVPPVLTCLIGRSLGSGIGSLDHYDLRDLAASLLGHLCNKYSKHSHNLKPRLARSCLKTFLDPTKPLGSHYGAILGLKAIGGAEVVRQLIVPNLKAYGELLEEDINTEGMKKPEAEKVMNAILNALGTLIDDDVPTMNGHSEQAMNNMRTKLVEKVGSVVGNRIADSGHTRLAKAVLDDTFIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR90</accession>
    <name>A0A0D2BR90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241749.1">
        <property type="nucleotide sequence ID" value="XM_016376473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR90"/>
    <dbReference type="STRING" id="91928.A0A0D2BR90"/>
    <dbReference type="GeneID" id="27329196"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02113"/>
    <dbReference type="HOGENOM" id="CLU_312157_0_0_1"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="144"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="947" mass="106878" checksum="F03B34FAF7EBC158" modified="2015-04-29" version="1">MAAAHLKTQILQAKIHPIGVPWSAFMPEGSLSAILDIQTVTEALADPTFSIPPHKLDDAAIIVVEQGMKVFSILLELNCEKYLSACIENNCLDSSLTIAETILADILSPEVAPHFYRLQFQYKAYTLQRSTFHRNLQEMHVLPYVKQKRIGGGGYSTVYEVEIHPAHQNLVPPSKISGVVRAVRKELDPDAQDKSTEAELLFVLRSLRHPNIVELLTYYTQHGVTNLLFLPADSDLHCLLQSPSRPEHFQSDFAFFNAMRGLVSGLSYLHSFRPRPEQSSAPNQATMHGYHNDIKPRNILVRGPDFILADFGTAKLKDALEETSTSWKNTTYEYGGPECRDPKTWLHGRVSRANDVWSFSCVSAEVAVYMVRGKDGVLQFREARVHDGEYGPQRCFHDGVSLSPGTDSYLRSIADADTFSCMGELLQLLGKAFQSKPESRPKAEGMEVGFSRITIRSVLEALKRAIEDDLKTVGLVGRGVFLARLSLEYNRLTSTAKFTRIHRTFTPPFSAFIGGPQFEKPEDDQDFRLNTIQQAVDDLLKPLSDHTRLSIDQTFCVLAAHSRPARSLQEISAFDFATPEVSDVDAVAAMKYMSLLLQRQKSASSDSPRLQSSLLRKDPKPTDLSLRPEIYYYTYGHQEGEEWKTLVEKVPYWVKKIPDSCGPEFPKAIESMFRRVSDLVEVLRTHPRPSGLRVLDCLGSCHDADRKCFQLVFALPVTETLPIRLNKLFQHGSSRLLAAGHRMKLMLAKTLVTCVQSIHTIGWVHKSISSLNVLLFPAAERRFETIDFSAPYLVGFGSSRKSKGDEYTQGPVLNDSIAEYLHPDYRLKRSIAKRAHDYYSVGLLLLEIGLWYSLSNIYDNTEFRQHSPDELREEYIRLCHRRLEDAMGKPYQQAVLSCLLFDSSESDDGEGDVEVEQVQRDQLDFQKHVADPLNKCFEYCEALGIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRM4</accession>
    <name>A0A0D2BRM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241246.1">
        <property type="nucleotide sequence ID" value="XM_016375970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRM4"/>
    <dbReference type="STRING" id="91928.A0A0D2BRM4"/>
    <dbReference type="GeneID" id="27328692"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01609"/>
    <dbReference type="HOGENOM" id="CLU_063930_0_0_1"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="119"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="264" mass="30358" checksum="8F80668FB6FDBBAD" modified="2015-04-29" version="1">MALASSATIPMLDATLVHEKPESIVDQDIPTTRNHDGVRIVAPHEYKEAAACLAEAFRFDNIVRYAVDTPDREHMSDEERFELHRTTMEYVTYAHCLNGLVLTAGEHYDCVALWLPPGKNIDDWLTIVRSGMWRLRYKLSKEGKIRFFDEFLPLLHDTKQEVLGERDDQSWYLNYVGTKPEARGKGYARKVIEYVSKLADDRGLPCYLESSHDINIIIYGKLGFELRKQIYLTRACGKELRLDVMVREPATYEKNGDPVVSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BS11</accession>
    <name>A0A0D2BS11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_01795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241431.1">
        <property type="nucleotide sequence ID" value="XM_016376155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BS11"/>
    <dbReference type="STRING" id="91928.A0A0D2BS11"/>
    <dbReference type="GeneID" id="27328878"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01795"/>
    <dbReference type="HOGENOM" id="CLU_855224_0_0_1"/>
    <dbReference type="OrthoDB" id="2394218at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW21215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="332" mass="37049" checksum="2502D82D9F0DF1CB" modified="2015-04-29" version="1">MTSDWSQLRQIRRWPGQNSSLEKVPTELIYNGNTVQLWGAECKTLATQDERIRTKRLFKNAMSARDVGAASHGHEVENARRYFKDFLTHVHAHIEASLAKQINDFKRLRIEYVFSVPTTWNRDADTLNEVKQTIRGVVGKTQYRRGIIGMSEAAASAVETGQDRFKKGDVVLVCDTGGGTADVNIFKFVSSEKEAARIKPLTYDEGAPAGAASIDQAALDYIISKMRSIEKLDKDSAIWALEAVQAGFSNIKHDYGRSKREGYYLLPVPGMSGSQPPSEDFELGGKGSQEICFKIHPKLLEEWFNSAVNDILAIIDSQLEALAREHKGEKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSP5</accession>
    <name>A0A0D2BSP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241661.1">
        <property type="nucleotide sequence ID" value="XM_016376385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSP5"/>
    <dbReference type="STRING" id="91928.A0A0D2BSP5"/>
    <dbReference type="GeneID" id="27329108"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02025"/>
    <dbReference type="HOGENOM" id="CLU_022379_0_0_1"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="154"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="521" mass="59550" checksum="447DD7A3C6A898AD" modified="2015-04-29" version="1">MAPPMPNPTKRMTANPAKPVARYRPGKPVAEQESSDEEEVSEEEKPQQPQRKPPARPPPVRRPVAPAREESEEEDEDEEGFVTEEEDEGLGLGPGQGPGTKLTQQTKSDSTLRRPAPRLSQAKAASDEESEDDSEEGSSDGEESSEEEEEESSSSEDEAPQRKFKRPTFIRKTDRQTSTLTKTQSTAADPPTSSAGAADADAARRLAQADLLIKDKLERDALARAAGKKSWDDDDDILPESMVDDTDGLDPEAEHAAWKVRELRRLKRDREALVAREKEIEEIERRRNLTAEEREREDREFLEKQREERDGGRHDAAFLARYHHKGAFFQGDEAAEILKRRDVMGARFEDEVSDKSLLPEYMRIRDMTKLGKKGRTRYKDLKGEDTGRFGDEVKRWKGSTGAGPRTEGDFDTRGLDERFLPDDQRRGGGERGGRDRTGPTGANASAVGERRDRDKDKDRYRSRSRSRERRKRSYSKSRSRSRSPRRRRRDSPSPDRHRDRVRDRERDRDGTSRREEEVRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BT95</accession>
    <name>A0A0D2BT95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016376570.1"/>
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    <dbReference type="STRING" id="91928.A0A0D2BT95"/>
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    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
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            <begin position="16"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="419" mass="45680" checksum="3706F775C36A687E" modified="2015-04-29" version="1">MPSNESIASIVKQIPYKVLILGGSYAGLGAALNLQDLCSGRKARFAAQAPDTSRFGKIPVEITVVDEKDGYFHLISTPLAHASSEFAPRAWTKFRDLPALKNIRFIQGTAENVDCSKRHAVILDAETKSPVTLEYDYLVAATGLRRVWPVVPQAKSRESYLSEAAEHIEAVRKAKNGVAVIGGGAVGIEMAAEIKLVMPDQKVTLIHSRDKLCSSEPLPDEFKDRCLATLHEAGVETIMGQRVLGVETFQSEEGDAISELTLADNSTLRAGYVIHAISRSIPSTTYLPASARDNEGYVKVTPRLHLTSDMPNALNHFAIGDIAKWSGIKRCGAAMHMGQYAAQNIHQLMLVEQEGIKPEFLELQEIPPMIGIAIGKQAVAYWPADGVTYGESVQEMCFGNDLGYTICWNHMQLGDECPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BUT9</accession>
    <name>A0A0D2BUT9_9EURO</name>
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        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
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                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KIW14984.1"/>
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        <property type="nucleotide sequence ID" value="XM_016382098.1"/>
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    <dbReference type="GeneID" id="27334854"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07771"/>
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    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="350"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
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        <location>
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            <end position="437"/>
        </location>
    </feature>
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        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="60"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="495" mass="55078" checksum="2C17E7A53DF76110" modified="2015-04-29" version="1">MSDSPKDPSTEKPIETIHLEKGDDASLTSSKAEGLEPQGEEPDWSPEEESALVKKLDFRVFPMLCTVFGLSLLDRTNISTAYIAGLAEDLDLHIGSRYSIALLVFFVGYAIFELPSNWIIRRLGAQLWLSFLIISWGLVVLCTGFVQSWKTLTVCRALLGIFEAGLFPGAVYIIGSWYRQYETARRVSLFYMASLLASGFGPILAYALSLIRVGNGDFRRGWRWIFIIEGIFTVVAGLVAPLFLVEFPERAKWLTPRQKHIASARLVTDKKSKEYVHPTLKESMKMLLDWKLLIYSLQYFVCASSVYSLAYFKPIILRQGMGFSYAMSQVLASPPYVFAIIMSLIMAWVSDKYRTRWTVLCAQSFTAVVGLLIVLYAEAPGVRYFGLYLAIFGTQANVPGTLSYGQSNTAEIRKKGVVAAAMISVGAAGGICGSTIFKSSDAPRYIPGMWATIAMQLAYSVSTFGLSMYLKRQNRLADEGKRPALENVEGFRYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXN1</accession>
    <name>A0A0D2BXN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LPXTG-motif cell wall anchor domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016380398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BXN1"/>
    <dbReference type="STRING" id="91928.A0A0D2BXN1"/>
    <dbReference type="GeneID" id="27333143"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06060"/>
    <dbReference type="HOGENOM" id="CLU_012620_0_0_1"/>
    <dbReference type="OrthoDB" id="5369729at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16009.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="938" mass="101367" checksum="69AC41171019E3D7" modified="2015-04-29" version="1">MENTSTTTVASPPLSCRAFTSPPCISNHSLRDDAHHDLCLRVSDASSFRRHTPHPSTVCIIAPAVSHDLTCMRPPLRKKPKLTATPTTTANSGDSLQNSDVSRSGMLKPVGLQKTTSVPSFNLHPLDYDDPNDCRPSTSSAAQPAIALHRIHSSSNHRSLSQKRPPASHSSYPVETICGPPPSYSTQQTRSQDKIRAVDRQLGPQPTSITTRDTPSHNINEQPHEPKKYLAQSSLVTRVPIASSSAESVSDEINTQDTSDRDTPITPDDLGSLVGATERSTMAESFVSAEQDLSEQRLKPSPIDEDSKGSSSDERKSEDLFLNIAKTDASRSSQVHSNIDKRRSRISLPFFSNARPTTGYKSSPIQDRFDTSSLSGRSEALKYYSKRASLGQHVPGALSRAYTEDTLRPDSLASPQDTRGIQDGDLSRRTLSRRYSNANTSVTGEPFSRHLQRPSTARNSRLVSDSGFLDRSKVPDHNATESTISTTAPSTVWDELDDLKSRIRKLELTGKLPPSSAAAMTTSERPKTATTAATTLSSSPKPKPGAAPLQSAIEGIPSNVHPTLHEALGKAKSALSSELYQKLQATAQDALQLSIMMTPEGYTGTGSTIGASAVSERQVRRRTESMCRSLTELAIAILAENKQAPTPGTRPSSRDTYAPSSLGLRSRRYSNEPNDRPPVSARVQSRLESRRTSIPLGATLSPQGATPEHTYQTPPTALPQVPATSSSRLGSTSNSLRSRRTPGQTDGITADEEASPSVRPVSRAMTEVSTYRNLARDRAAYSREYTAQHPMPQHARPRSRETSNPMRSAMPSNVSSSLISRRKHASPASLVGTPDGNPTTPKDQWGRITIVPAAMSSPIEVTPESQVTLRPSNSRRSLGFASRISSVSSRLRAAKAERSASIRETPDSEALRNIAPSGPELDNMALERHNSGHSVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXS2</accession>
    <name>A0A0D2BXS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_06110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236275.1">
        <property type="nucleotide sequence ID" value="XM_016380448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BXS2"/>
    <dbReference type="STRING" id="91928.A0A0D2BXS2"/>
    <dbReference type="GeneID" id="27333193"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06110"/>
    <dbReference type="HOGENOM" id="CLU_616816_0_0_1"/>
    <dbReference type="OrthoDB" id="2359117at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039198">
        <property type="entry name" value="Srl3/Whi5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246:SF1">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW16059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="414" mass="44346" checksum="8E55E7D51836C2A9" modified="2015-04-29" version="1">MLDPHPLTLAPPDAVSTNLPRRSEDSNTSQQLPLNISSSDVSSTVALPTVPDREDDETPPTSTTSSQLGSQETRSIESQENKESTEDHAAVEAVREHRLLTNSQSPPPHSLSGAKRTASGEVKRSSVNGLADVVGQSKDLGHALTTSSVPNGNISELSQQLRTRLKYAMIKVQNGWQTRSLDEVESLASQSPRSTVSGFPNSPRPRGPLSPRTVMSRSYGRESSESDSSDSTLESRGLVTLNSPQISSRRALAPPVDIVPSSRRRPTPNGSYQNPISARRASTSSRVPTSHRTPSQNAAMEADAVETLLFMASPNNSGYNPSLSQDSTIRSIPSFAASQLTSPLRTQFSQTSMTSPKKVAFPNGRPAYDKAAIIDRMLNDISDDSDEELQRAFELAEKSKASAPAAAASPTVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXZ2</accession>
    <name>A0A0D2BXZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236380.1">
        <property type="nucleotide sequence ID" value="XM_016380553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BXZ2"/>
    <dbReference type="STRING" id="91928.A0A0D2BXZ2"/>
    <dbReference type="GeneID" id="27333298"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06215"/>
    <dbReference type="HOGENOM" id="CLU_002229_1_0_1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053210">
        <property type="entry name" value="ANKRD12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056485">
        <property type="entry name" value="ARM_KRIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056015">
        <property type="entry name" value="DUF7593"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149:SF14">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24521">
        <property type="entry name" value="Ank_KRIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24513">
        <property type="entry name" value="DUF7593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="406"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="KRIT1 ARM-repeats" evidence="4">
        <location>
            <begin position="516"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7593" evidence="3">
        <location>
            <begin position="1063"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1016"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="949"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1270" mass="141733" checksum="2C30BB30DF8197D9" modified="2015-04-29" version="1">MSESVGPDVAKEVSPDKAVDHSTANGASSHSASTPPKPEELISSKAESAAPVPTVDQTMADSPDAEADGDSEAETLIQSPEKQRTTAGSTADNASVAGSVRHTAAKGEQSSNGASATEGDSKSRKRKRSVDDARDELAFSVSSRQSSPLSSLLHPHSEADNDSDVSSHIASTRIKPSRKKREKRSADPDDAEEKPVENQIRRRRPSDILPKQRTKNNSSGVDPGSSERRETRSATYPRHSSQERSPSPPPPPHRKEHRRGVSTQFTLGDVERKKRGRPPAIQTKRSGSADHRRRSVSSDESDSPRRVRPALHKFISTDHENMSPAKTAGPMVRKLKDRNGRTHLARAANNNDLEVAKQKLAERPEDLNEADNAGNTPLQIAALSGFTEIVKFLLENGCEVDTLNIDRDTPLIDAIENGHVDVVRLLLEYGANPRRGNAKGEEPYELVDKNDENYDEIRALIAKAKDKPVRRVSNEHTEVSRDGHSSRAASAASPRDSPPINGPRSPPTYSSSRRRKTGRSESTRNDLLWQANTQENLTRLAGKGDVQGVGNILNILQKAETESLIAAAKAGHEEVLQYLLAIGDAEPDPDPVKGLKLGHNTPMLAAIGRGHPEVVKLLVELDGFDPTRKLLKGKTYHEIAAERKGEQWQKEYDILKDAYDKAVGGKLRKTTSPRATRDNEKHRSRLARRSHSPPANKQRTSSSPTLTHKLNPNKSPQSSSKDGDRDRTSTDVLERRKNAALRKERSDVAVSSDQDQTVSGPSKGHMKRRSQSDAQSAFLDVEGTHRRRRLVTGKEHRRRKSAITEHSSDDDGSTIPGKTETQPTALKRTRESLTPDQDRAQGESAGSIVKKRRTVVDSSPEASRPDCLTQSSRDVQPSIEDKRSTPREGRRHDHLSPKSLGTEKNQKSAGEVLEQEYAPIAPPARPSPHGNDIKMEEVDVKPTVAELQAQREEEARKAEEARKAEEARHAEEARKAAEAKRLEEERIAAEKAEEERRVAEENERRRRAEEEAAVAQRKLEEEAAQKKREEEERQERIKRELEERQRRQEEYIRQQRLEYERRRREALPIVLSMTALMIDNNDPVVRSDAWLRKFLPLFTVKTSQLTSESVPVTTDDLWVPNFQVAGLLATKDLNLRNYTSLEKRPVTQNQRLCLWKVSRNMLSFEYDATAYNTTIQQAKEKEEEERPKFLNMEELFWVKYSDFEDQLFRHPHLAALLPLKKQAISVRIPHGQLPATPGPFANGISPFQAKLTNGITSHLPPSPYGNGYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C1L4</accession>
    <name>A0A0D2C1L4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237760.1">
        <property type="nucleotide sequence ID" value="XM_016379083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C1L4"/>
    <dbReference type="STRING" id="91928.A0A0D2C1L4"/>
    <dbReference type="ESTHER" id="9euro-a0a0d2c1l4">
        <property type="family name" value="BD-FAE"/>
    </dbReference>
    <dbReference type="GeneID" id="27331821"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04738"/>
    <dbReference type="HOGENOM" id="CLU_012494_8_1_1"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="51"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="312" mass="33842" checksum="61A34B7E9F9EB7FD" modified="2015-04-29" version="1">MDQLPPFGKAIGLVIPPTNGVYAPLLAKNASAILSANKTTFAYGADPRQQLDLYTPSQSEDVTDKSSPRPLLVFVYGGGFANGDKSSEAKPLVYQNLGYFFSEKTGLETIIIDYRLIKHGAKFPSGGEDVDAALQWIAQKYGGQKRDVYLFGNSAGGINVATWLFEPLFQKSRQSLFAGVDGVKVSGAILLGALFDFRQSSPPLRQALTGYFGEELDQSSTVALLDRIEPTGELSSGPWPRFLIVDSELDPDDIIKADQDVLRRLKDVPNLDVGYVQIKGHNHISPPLALGTSIAAEEEWGYNLASWVKGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3X9</accession>
    <name>A0A0D2C3X9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238560.1">
        <property type="nucleotide sequence ID" value="XM_016376990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3X9"/>
    <dbReference type="STRING" id="91928.A0A0D2C3X9"/>
    <dbReference type="GeneID" id="27329715"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02632"/>
    <dbReference type="HOGENOM" id="CLU_027816_3_1_1"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF697">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="51"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="456" mass="49471" checksum="0F3B489248F877FA" modified="2015-04-29" version="1">MATPSTYERKVAEDVIEAPRPADDYEPEQKMDILEAREIFHDENEGVKFRTVSWQRAAIIFLKIQFAMSILAVPGALATLGAVGGALSIVGWEVLNTYTAVVLGDFRNRHPECHTLADMCGHIWGRMGKELVSLQILVAQVLITAAGIVSCSTAFNALSEHGACTVVFSFVSAVLITMFSSVRTFSRLGWLTWMGFTTFFIAVFIFVVAVTQQDRPAAAPPTGDFNLGANIFISGSGSSMYLPVISEMKKPRDYRKAAIVAGILVGAMYLTFSLVIYRYCGIWLATPAFGSAGTLFKKISYGIALPGLVIGVGIYQHVAAKLIFVRILRNSSHLQANTVVHWSTWLGSNLILGILGFIIAEAVPILNYLLGLAGSLCFAPFSLIFPAMLWMYDFKGYRSGSTVQKLSYGAHIMIVLVGLFMVVGGTYGVAVSIRDAFDNGLISKVFDCADNSGTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C4W6</accession>
    <name>A0A0D2C4W6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238845.1">
        <property type="nucleotide sequence ID" value="XM_016377275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C4W6"/>
    <dbReference type="STRING" id="91928.A0A0D2C4W6"/>
    <dbReference type="GeneID" id="27330001"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02918"/>
    <dbReference type="HOGENOM" id="CLU_002057_0_0_1"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239451" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1031" mass="110503" checksum="B52AA558B7AF4EB6" modified="2015-04-29" version="1">MLLLHALFHAGLWALVTPVSAQLPYNPTRIIPTKNGDLAYIFTPQSSSSSQFSLYSINVSHGFNSTSTKDTLTENLPFLSGTASEAFIAIPDEEGITVLAGDCNNSTQEIGLWRLETKDGETNSTWLHYPLSTNDTSVRLRYLSAGFSFSPTDSSDDVSLYVFGGMCPKTSTPNSADWVSDATYSNTMLTLAPSSGSSSISPYQLSLTGARAPPIAEAGLTITPLTPVFSNTSDTSVSQQQNVVLLGGHTQTAFINMSQLAIFSLPQESWAFVGASQPQDGTTVEPRSGHSAVLTSDGSRILVVGGWVGDVSTPAQPQLVVLEVGQGYGGEGNWEWTAPSASSSPFSAESGVYGHGAALLPGDVMVIYGGYSIGKSSTRRRDGVVGDILFLNITTMSWSSTYTNPYPSGSPTAVAGSSASSSGLRPAEKAGLGAGLGLGIAAAAGVAIVWLLYSRKLQKKRAIREKELREQALGSRSRFQTPSPPPDHDLDAPNFRSASWGALQEKHIESSGNPYPWAPVNAPGEPGRLEIPRDEDGNYAKLAERTGVLMEVPSPTRGLRRSLSNRVSMSFGPFNQHPPTGVPDSMFRIDEEDEGSQSGSSRRIKGLHGNLDGNSIKSDPFKDPTTAVEDPAARRKKEVEGWVEDWQSAAESFSVSRSTSQAYSRTHSNLSSFPPLTTGGDVSRQGSPEKSDRTGSNLSESSAFTSSSIQRSMTGTISRNVSQRSVSAGYALFAGAAAAMSRFGGGRGAQNETTNNGGLSRAPSNRSVSLNTDSNGRPNARDNADKYAFARGNPWAPVPLGESQGLLKTRGQPQDNRSYRTLPESTLADRYANASSLSGTTRRAMNLLGSMRRVFTGTGNVDVHERVGALEARSTQSSPTKRPEIIDLAPSRALSVGASSFWRGKRGAKDWDEDLPARGEAGPSSTHRKPLPGQAVDENDEELGDEDDDWDVETAVQKRVVQVMFTVPKEKLRVVNADALSLLSSNRSEADHEEDRERENIKRMSSVREGDNEDYEPDDSTTQMKGKEREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6T6</accession>
    <name>A0A0D2C6T6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_03588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239510.1">
        <property type="nucleotide sequence ID" value="XM_016377940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6T6"/>
    <dbReference type="STRING" id="91928.A0A0D2C6T6"/>
    <dbReference type="GeneID" id="27330671"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03588"/>
    <dbReference type="HOGENOM" id="CLU_102236_1_1_1"/>
    <dbReference type="OrthoDB" id="2163284at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW19294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="83" mass="9544" checksum="A36FA11AAFF0C04D" modified="2015-04-29" version="1">MSPRRNSEDIERLERGVRESLKEQARNLQSSLAALAEKIDEVKSDHDKLENENRFLQDYIGGLTRTMSRDNLGRSGSVRKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C971</accession>
    <name>A0A0D2C971_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240325.1">
        <property type="nucleotide sequence ID" value="XM_016375049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C971"/>
    <dbReference type="STRING" id="91928.A0A0D2C971"/>
    <dbReference type="GeneID" id="27327767"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00684"/>
    <dbReference type="HOGENOM" id="CLU_051357_0_1_1"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="315" mass="35947" checksum="73594EF4748E7772" modified="2015-04-29" version="1">MAYNKAFNPDALPAHAEPEQAAQALSQLQGNRKPSPSARYPNQAQPQQNDPRPPPNGRYQSPASHNPLQRPPPAQNYPQPRPSNDQSYVDNQYSRLQSPPPQSYGYGRGQNQQRYEDPQYSWKGAEQYPGRGGGIPDLGSRSPYDFFRDANESQTGNMTSAELGKALVNSDGTRFDSTTISSLMRMFTTSSSNSRDDLTLTFDEFKSMWEFLAAWRRLFEQFDVDHSGRVSRDEFSRAMTAFGYRLSPPFITMLYNTFNDRSPAKHQGMSFDLFVQACISLKRMTDVFKKYDDDRDGYVTLSFEEFLTEVLRLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAR4</accession>
    <name>A0A0D2CAR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_01246</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240885.1">
        <property type="nucleotide sequence ID" value="XM_016375609.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2CAR4"/>
    <dbReference type="GeneID" id="27328329"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01246"/>
    <dbReference type="HOGENOM" id="CLU_000459_2_0_1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001152">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="2058"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1862"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2097"/>
            <end position="2242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1465"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1868"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1888"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1930"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1948"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1987"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2097"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2121"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2134"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2169"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="2196"/>
            <end position="2212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW20669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="2242" mass="249618" checksum="8617305203E669B8" modified="2015-04-29" version="1">MAEFITTLQELQQLPDGLHLLCPRQSDEDFDRYEDEHDCEGEGGRPVDPARKARFQETKIRRKKFISSLQLLAYDGTESEQYQAYIWDTVDAALARCDICIREYYIAKVDFLATLREEYEEEDIKNFFSIINRRDVQRVTRGLDSADQTLQNLPGPKRVTSALTPKDLHALYEALVCEVFLRDENLLKEHFDSPFKTIQSRKPLKMREILPAATRFLFDTNPVRLAWASSIWKRLDRVVKDIEFDWAIKDFLQEKVQYAVEPSDTTRLWSALKLIVSKLDHRMITYKLFDLQPNLCTTALNHLSRRSSAVPFIVQTLEDILDKAPDAFWQAMGSISSQTIVEQIFASPNFNRHLQESVRPSPETDGKSHVTSDPRIDNDVLSWISAFMESLKPANRPAAAQTIVAQLFERINDISLVVPARLICFETAVSVLLKTVISFTTNQDDQKTIERLVLSDTLNLVGYRLDELLNPKDPALAEAMRAVKPQLRGDILNLTKNAVALECQCLKADFEMISTKVNLRKGSSSYTPELWTAIIDNLRDDDPSLSSAALLGTMALPGLEQFRIREGSPDVQERKSFNAIFDKITGMLGKLLERISEFSPDHLDRLFRAQDTSMSLIAALFSPHQSTYEAAIELIKNISGESGRKEALAHLISAFLGVTIYGICWTFRRIANYKTFASVPRMLKTGMEILEILCNLTDGQLRRAKISSRDASAIQSYWSYQWIALRVVYSQTEKWSLELHNKELMVEVCRDAMQYAQALFDQYDLFSSVITKAKPDKAKEIHRLLLDSDDPSVGSPLGTLDAMSKWLRLRDEYLAETLVSLITNMLYRLKGHDALNAENEGLIYIQEVTTKQSIKTILTSSQKAILVRALENYWGRQIVKPVVKKQATLNIKGWTESAAVARSDASASESRDVDADEFGDDDIADEDLVEIASKTLGTQKASITSKDKNQIKNLLIRQQPVKPKATKPSTVDLAAKKAQEAKAFIENRKREEAARKLRDKEAALKLRGKIGVGKQTAGQGSGLSGLGVVGKDHTVGSSGIMVSSDSESDTDSDEELFGKLPITQGTTVRNQAGLRKPLSTGPVRKVKQVRSQRDIRARLAPDLTELHRTILSWDFFADTDLPPNSQKNDYTLVTDTFRTPQDYQSTFEPLLILEGWQSFRAAREDGTFKPFEVKVANSLIVDQFVEINSQVSMAEGKDLGISTSDVVLLSRSNQPDRDASEPHCLARVKEITRKKGEVQIVYRVSASANPLRPYLNDQALVYGVQILSLTPLEREYGALMALQYYDLCEEIIRAKPSPILDYTEEDLEPLKKTYNVNLAQAKAIKSALDNDAFTLIQGPPGSGKTKTICGLVGAMLTGSIKKPDTSGQRLNTATGRPVGAPASAKKILVCAPSNAAVDELVMRLKKGVTLRDGTHERLSVVRLGRTDAINTNVKDVTLEELVNAKLGTAAPKDPRDDIHSVMMKHKAISEELNALRNRINDQRGRGQPVPSSEEQLMDALKREKNGLSSKIDDMRERQNTASRDMDLNRKRIQQEILDSANVLCATLSGSGHEIFQGLNIEFETVIIDEAAQSIELSALIPLKYGCSKCILVGDPKQLPPTVLSRAAAKFQYEQSLFARMENNHRKDVHLLDTQYRMHPEISLFPSKTFYDSRLKDGAGMAKLRHRPWHNSEVFAPYRFFDVQGMSQAATKGHSLINVAELNVAMQLYDRLLNDVPKYNFSGKIGIITPYKGQLKELKLRFKQRYGEDITSRVDFNTTDAFQGRESEIIIFSCVRASTKGIGFLNDIRRMNVGLTRAMCSLWVLGNSQALMQGEFWKALITDAKGRNLYTQGDITSLLRRPVLTDAMMEADVEMMDVDEPTSAIEPESDNHHHSTMDLDRPEVETAQPVISRQNSDARNSNSKGPSPAITKQPDSRPGSSSVQPTPLPSRPSSRLSSDSPMSTSSKPDAGRLDPSRPESKRELIKSNTTGSNKAPPAQVRPEAYSDSKLSYSEQSRPGTHGPSGGGNGLNDLANCAICGSYDHYSFNCDNEVAKAAALGNCHRCHRPGHNYTGCTAPRCITCGEVGHASESCMAPIRHRLTKAQQVEVHKQEVRFGIARDKARERRAERQLGEHGAKIPTVKSTLPSANGQASDAKRKRDESTESSDRGKVKRRDKAAAGKVPAHNPGVPNNNSAPNTFSRPPPTGPSAGVVGLSRPPPTGSAELPPRPPTGPGGRPVTMNNGQPMVRKKRANANDMFVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCT7</accession>
    <name>A0A0D2CCT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241530.1">
        <property type="nucleotide sequence ID" value="XM_016376254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCT7"/>
    <dbReference type="STRING" id="91928.A0A0D2CCT7"/>
    <dbReference type="GeneID" id="27328977"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01894"/>
    <dbReference type="HOGENOM" id="CLU_009665_6_4_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="310"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="502" mass="55241" checksum="0EDC60BC9F3398A2" modified="2015-04-29" version="1">MPTEIKVLIAGAGIAGLASAIALRRLDTADVRFDIQLFDKATELREIGASIALSPNGLRTLERLGVDNALGDDVGFRGPSARPMIYHHWKTNEVVSADEFVDVPDRKHQTARFHRAHLHSALLAHVPGETIHLGKVVESAAVDDRGDDADGVTLLFKDGTSAKGDVLVGADGLRSKVRRAFVPEHTLHYTGRTWIRSTFDASLVDDIADLPSDSAHWWGPRYTFFASRLGKNMYTTVGNFDPDDFPAEREGGGGRQDKSVRWDQEGDVAFFRHLYRDWNPVVKALADATPHVRLYPNLAGEPLESWVFAKRVTLVGDAAHTHGGAHAAGGSLALDDAWALYRSLEHVLKATAVEQLKPKGGDDGGSGGGAGSKPKSLGASQLERAFTLYDKTRRPHTTRLVLSVLAAAEGNATTPGTDEQLRQKMINRPNMTWLTEHDVEATFARVLETENRQEREEKKNDHEYHDQVEKETKEHHVQVEEDGVAFDDIKDAIMDVPVVMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y4I9</accession>
    <name>A0A0D1Y4I9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_11957</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Vacuole membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230072.1">
        <property type="nucleotide sequence ID" value="XM_016386264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y4I9"/>
    <dbReference type="STRING" id="91928.A0A0D1Y4I9"/>
    <dbReference type="GeneID" id="27339040"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11957"/>
    <dbReference type="HOGENOM" id="CLU_017518_2_1_1"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW09856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="553" mass="61003" checksum="7791FA311E8981B6" modified="2015-04-29" version="1">MDDHITAQQEEAHPTKLAFTSIAAPAPDTSGESALAPSDLQYYDLDTNGPAATKKEVFSYYAYYAGNNGIGSFQYSNLLFQNLIYQAGFNPNVLPLGSSSCDVDPTAPCHVFWNGGTKSYSSVVLIASGLTFLCQGLVFIGVGSLADYGNWNPWVVRTFSVICWAFEFGFLGVRRAYQWRTAMALYILSAITFWASYVFFNAIFPKLSHDLPEVRTAHDEMLEGKISGEVYEHKCSMARSKIMNMSYGWNNVGFTVCGALSLAALAGIGANDSTAQNNWGYSVSVAVCTGFWIVLAIPWFLWEKKRPGPPLPAGDNYLTFGFKQTWFAAKQVWTLKQTFFYMVAFFLLADGISTIITLVSIAQTKVVAFSATQNTYLIMVQGGSCVVGVFGAYYVQRLFNLRTKTMLQACNIGCVLVALWGMIGIWTTKIGFHNLWEFWFFNAQYGFTMGAQFSYGQAFMAELVPRGREYMFFSLLGIVSKGSAWIGPIVSSAIVDVNGNAWTPFPFVAALCLVPTIGIFFVSESKSRLECAEYLAKEATGLRKLDITAAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y6F9</accession>
    <name>A0A0D1Y6F9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230677.1">
        <property type="nucleotide sequence ID" value="XM_016385733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y6F9"/>
    <dbReference type="STRING" id="91928.A0A0D1Y6F9"/>
    <dbReference type="GeneID" id="27338508"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11425"/>
    <dbReference type="HOGENOM" id="CLU_026929_4_0_1"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="455" mass="50163" checksum="8787AFA557DCE5D5" modified="2015-04-29" version="1">MLLGPGPPTPMQTDFKPHDYPSYHKPPPTRTYSPPESPRTLSSFFEDSRMNNTHRGLPLPAALSLPPPDRGHATAPPAPLAHLPAPPSQWTGQDDSMRSWLHAKAEEDRRKQEEERTRQEGLRLDQRRIEQTMLRESLQGGIPPPMVPLIFAGIGGGNLPAHTLEWAQQYLASLSIQNQQQQQQIQAQQQQLQQQQQLQQQQQISPDVHRDSRMIPPNPYGSIPPPQPQQSLVSTQPGQAPSHGRNSLSGPQGATSSLSRLNTTEFVPTSATVQGNRQSIHQLQHPQTGSSEQSSTPGLFFHHWTPPSHSSGGQPPTTSGKSTQGSPFSQPPASHLRSDYQHSPKKRKVAAGHTGPAPTSDPSLPMSSRSSREREFSPGHRHRSDRHSRQNSDASMRDHDLGGRHVPRPSSRQQRRDEAGGAAPGPRRQLTNSSTSGSSDDHPRSVYEGYKSETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y803</accession>
    <name>A0A0D1Y803_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_10355</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231272.1">
        <property type="nucleotide sequence ID" value="XM_016384670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y803"/>
    <dbReference type="STRING" id="91928.A0A0D1Y803"/>
    <dbReference type="GeneID" id="27337438"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10355"/>
    <dbReference type="HOGENOM" id="CLU_015166_3_1_1"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000029">
        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="122"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="213"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW11056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="320" mass="34960" checksum="3934E453AFB6FC03" modified="2015-04-29" version="1">MTASSSPDAVPGEEFDYEALPPNYGLSHNMLAGAFAGIAEHTVMYPVDLMKTRMQVVNPSAGGLYTGLSHAVSTIYRLEGLRTLWRGVTSVIVGAGPAHAVYFGTYEVIKEMAGGNRADGKHHPAAAALSGACATIASDALMNPFDVIKQRMQVHGSSYRSITHCARSVFRAEGLSAFYISYPTTLCMTVPFTATQFMAYESLSKIMNPRKEYDPITHCVAGGLAGAFAAGITTPLDVIKTLLQTRGLSQQDEIRNVRGIWNAASIIKKEYGWSGFMRGWRPRIISTMPSTAICWSSYEMAKAYFRRTLREEHEAHISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y868</accession>
    <name>A0A0D1Y868_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231392.1">
        <property type="nucleotide sequence ID" value="XM_016384790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y868"/>
    <dbReference type="GeneID" id="27337559"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10476"/>
    <dbReference type="HOGENOM" id="CLU_274179_0_0_1"/>
    <dbReference type="OrthoDB" id="5343018at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="247"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="983"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1134" mass="125994" checksum="1D769CCBEDF571A4" modified="2015-04-29" version="1">MDDAAHAHPRSPAATLVRPRSTTALGLYEQQTNHTSPLSVPHNRQQRLLNTRHARFSAQTLSMNGISIPFPRLGKPTEIENPYYTTPRMAKRQDAAEAAERSQDMSSVSPRSSILNEITNSSGYRERSAQRRAPIPVFQDNPSTNSVDSGKQHTPSIYQDPPSEFQTPSVTGSRSTPESTAMGLREVSVNLHRTSPRKDSPSFRSIRSGSHRRSSHAKPRFNSEEYIDHIENELQMVKDAMYSPTTNTSWKEKLKKAKDENERLKKEMDVMRTSFELELQDTVERAAATELQLKRKIKDLEDEVALKQALIQDLEIDREEKRADQTTFEVLRARLDRVEEEKASLAATNLDMMKRNEVLTQLLALSPTKAQHHFELPTPRRRSARPMSMIIPRAPSSPPARTPMSRPQSVVISPALPIADYFPFNAGSSPDAASAFGTTGASPKVPDDTGSVRSESSTSCPRLTNSHSRHMTNVSQVSSSSESTPHSDVRPSLPVRQPSKRRPRRFMPGSTQLKPLLLSTFTADNGNMPSTSPMTSPKRMLPSSLPCGPSDVPRKHHATDSRSTTGDFIGTSSPISPISETVGQPGPSFQSLDEVFDEHEERSRSEAINEALAKLTQGSDGAEYNTPVKTSDIEMTVKVPASGTSKSCPRVDSWLLRTSISTSEGEDSAYEADVDGGDNPMTSVLAGDSDRPNIAARRHLGHDVDIPRPLFSTQYDMPLGPTHSPSYYDESPLNPRQRHKSILGNKDRISGSFKAREKALKRASMPERTKQSLTTDPIIIEREVIDNTDRERHLPKRVRNTARPRHPLELLKQRNIGSRTLAAMTIRTVYATLTRYTSYIRSFRKDPLALARRVIANAWRVNWGTFGKLSWWVLGLFLGHRSIGYEESEWDWEQYDGESIAIKHCENTAVTVDTDAKPDELVASSDTPNGTACGNDPTCEANESLAKSTGSGWGQSLYLWGKFSVAIMLAVGGAIVKGPAEMLRETEDQKRSRQRGTEDDDQSQRPGTQQSEEETIGQSSGQDDQAQTRAFASGLEPRPPEHNIRRRRSHSSPTPAARDFRHEPSCTESCGVSGLTQPLELDTVDQPSALDHCQYLHDETPQPSRNNRLTVFLDAVMEQDNSDDMQILQLADPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y874</accession>
    <name>A0A0D1Y874_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10486</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231402.1">
        <property type="nucleotide sequence ID" value="XM_016384800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y874"/>
    <dbReference type="STRING" id="91928.A0A0D1Y874"/>
    <dbReference type="GeneID" id="27337569"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10486"/>
    <dbReference type="HOGENOM" id="CLU_023417_3_0_1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="516" mass="58877" checksum="BE8B9516CC8B2CEB" modified="2015-04-29" version="1">MTKAKLRTKIGCLTCRKRKLKCDESRPCCLNCTFSRRLCVWPTPAELYDRRNRRRSEDGVPKSATGGDNDVNDVQNSSNLLQPGDCYNLDSTWLIVSSPQPRTSISSECDNSLLCYYTDSFLSVILLPTTKPSDYDSFRSYTLMLALECQSVKHAVMSSSAANKYMLTGEDHFRRLSLEHYAQAVKEVNHALANIDYSRESWADPLLISVAYLYIHAFWGPDADKDAAKHVLGMQQLFKLRYTGNTSPVCVDRPFDRIMVESALYHSFLLAMRNPFALDFHIDSFFLSKTLDLLEFEVYVDPAESAKSPVIGAPPSIYRLTLEISRMFNSGSLDDAEEFTRIRSTMDYWEQLLDSEASIFRDSEFGDAVELYILAASLLLDWISELPHGAGPITLTALSMLGRSTTVALDGKPRHRWQVARALSVLRRPDTKHYWTWCFLSSWPLLVFGYAVEDVESMDLVKEVLNESRHCIGYAEMERIERELEGVWKIRLQENCHREFLPDAMSLQGQKIYALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YAG5</accession>
    <name>A0A0D1YAG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232142.1">
        <property type="nucleotide sequence ID" value="XM_016383519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YAG5"/>
    <dbReference type="STRING" id="91928.A0A0D1YAG5"/>
    <dbReference type="GeneID" id="27336282"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09199"/>
    <dbReference type="HOGENOM" id="CLU_092544_0_0_1"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23032" checksum="6941E16BA06F3B0B" modified="2015-04-29" version="1">MVEKVYVTYNEIHKLCQTSAPRILEEFQPNLMIAIGGGGYVPARILRSFLKQPGAPNIPIQAIGLSLYEQLSDAGPVEAPGTKVTRTQWLDLSSLEMSNLIGKNVLIVDEVDDTRTTLEYAVKELEKDVELARQQQGRTEKTKFSIFVLHNKDKVKKGQLPEDMINENRYLAAVTVPDVWICYPWEATDIDEHDELAAKFGNGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YAK5</accession>
    <name>A0A0D1YAK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232177.1">
        <property type="nucleotide sequence ID" value="XM_016383554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YAK5"/>
    <dbReference type="STRING" id="91928.A0A0D1YAK5"/>
    <dbReference type="GeneID" id="27336318"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09235"/>
    <dbReference type="HOGENOM" id="CLU_662277_0_0_1"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="29"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="415" mass="46078" checksum="EEF45C7576FC1181" modified="2015-04-29" version="1">MADHAFSTQLPSMVRKPKAVWPGLVKMGMYQKQIAGDGNCLFASLSDQLYGTPAKHPEIRASIIDHMRTFRPLFEHYVHKDDVQQRRTLRSAKSAVRQESEDAFEEYLSLMSRPGTYGGEPELVAFCQVFDQDVTVHLPRIQNFNRDSISYTNEHRENSSMGAPLHICYGGDEVTRAHYDSARSRDGSTPRSRDSPLLRPQDPPGNSISGTLSSSPVSSLTSRAIRNSRAELSSELIQDFLQKSKKESENNLIQLNEKYRARSPSVTSSQRSSSSKRSLDDDGEPIRSSKRADRRKSTRKRGDIAVTIPDPDDELSPRIPVESPGPDTPLSTQDTDVSSDAPLQEPPTATTLKAIPIILDGDHLNNNHVSHATKQSTTQQGRTSIHVLSKRAQPAESSNPRMISVAERPKSTLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YAU4</accession>
    <name>A0A0D1YAU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_09285</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232227.1">
        <property type="nucleotide sequence ID" value="XM_016383604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YAU4"/>
    <dbReference type="STRING" id="91928.A0A0D1YAU4"/>
    <dbReference type="GeneID" id="27336368"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09285"/>
    <dbReference type="HOGENOM" id="CLU_016218_3_0_1"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="490"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW12011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="580" mass="61844" checksum="31D479DD40F70628" modified="2015-04-29" version="1">MSTQTPASPTSAAIAPLNPTAASFSMPSQNEGTLANGIVSPSPSSNGAIDRSKDSKRSKASRPDAAARTTTEQNIAEAGAGVKLTGAELKKQKAAEKAARRAEKVAQKGSEAQAQNTSNSSVKAESHQRRPSTTKRESDTGSTHHKRTLSSSGGKGLPLRPGQQQNQQQTSTASNEKLKHSEAKRVSMFSHLYPKEKRATLASAGREIHPAVLSLGLQLRDYVICGGNARCVATLLAFKKVIQTYTTPPGVALSRHLLTHLNHQIAYLRNARPLSMSQGNSIRWLKNLISTQPVDATDSEAKKSLCSEIDRFIRERITLADEVIAREAGSRIDNGEVILTYGKSSVVEKTLIAAHRAGKDFRVIVVDSRPMFEGRNLARSLVRAGLKVQYSLLNALSDVVDQGSGVVTKCFLGASAMLGNGALQARAGSAMVAMMVKECSRNRSRNVPVIVLCETVKFTAKAALDSVIMNEVGDADALIEVHQSNVLSSAAAKKQDQNSAKSGGRKGATKDKDDEDEDKAAGSTKGLEGWKDQQGLYLLNLMYDVTPAEYIDAVVCELGSLPPMAVPVVNGVHGDDQALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YB67</accession>
    <name>A0A0D1YB67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232387.1">
        <property type="nucleotide sequence ID" value="XM_016383764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YB67"/>
    <dbReference type="STRING" id="91928.A0A0D1YB67"/>
    <dbReference type="GeneID" id="27336529"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09446"/>
    <dbReference type="HOGENOM" id="CLU_015980_0_0_1"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="426"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="663" mass="71643" checksum="E8D3D03C3E94CE99" modified="2015-04-29" version="1">MDRPPSRSRAPLSLEALIDEENREVLAAMDRSKRSASPLPKVAHARTATPPPPIRSMLDVDDFTPRHGSIAGIGVGITSPRRSSRLDPADPSTYTSPHSSKPNSPVLSKAVPVSTRQRGSSDADRPTGLPKIQPDDKRDFEQNYQFDIASIPSSAALRSPAEGKRPREGSSPSMAAAMSGDFSNLYVAKPKGAGNQTSTAAHHSRSASSPTMSSRSDLLSPPSPRGHLLLDPRNSAESQASNKSDSFSTVNDDSEGPSGRVPRDGPIEEDAVESSDEEVDSSDEDETTRGRPERRPNSTEDPQIIAQALSKDKENESTATPPVKSLLEPSISITSPSGESMSEQKPEHKPEQKPEQKPEPYAPSTTSVEDEDEDWAAIQKAKRLAINISPVDSSVANRDCRVILRGDWLGCKKKAEAGRRSSRLYLVCSDLSVEASYAMEWVVGTMLRDGDTILAMHAIEDESAGKASEEQRDALTAEGARAGQETADVMETLTRQTTQGGGISAGLSAKNKYIPATEAESLSGSVDARKTSKKQMERLRAVDSVIENFLKLVRKTPLEVRCTVEVIHCKSPKHLILGAIDALEPTLCVVGTRGRSSLKGVLLGSFSNYLVTKSSVPVMVARRRLKKPRSDVKISSTKIRLSNNLSATHIPTKRRSLTQARID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YBF7</accession>
    <name>A0A0D1YBF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino-acid N-acetyltransferase subunit Mak10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_09542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232482.1">
        <property type="nucleotide sequence ID" value="XM_016383859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YBF7"/>
    <dbReference type="STRING" id="91928.A0A0D1YBF7"/>
    <dbReference type="GeneID" id="27336625"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09542"/>
    <dbReference type="HOGENOM" id="CLU_011757_0_0_1"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="5">
        <location>
            <begin position="30"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="6">
        <location>
            <begin position="329"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="669"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW12266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="88551" checksum="0322F4DFBE9F8BDA" modified="2015-04-29" version="1">MVQPQIVHPNVQVNDITRQFRQAVSTLRPGGLVKDEHFTLFEAVSALEIGDPKMDSGSVAFDPDSEAEYDFSTTHSPEEIIWLMDELFCREVAWHKGHPLSQTLFTSLHIERLLWPEPKRLTDARFFPEGSSAAPSSSLLENVLRPFCLGMIKACDLVLEMVMNSHYYEEEDFATQIFNTPLLHIFQTDEILSELQGAELFLKQSDLDGDMRKALLVRIRARSSFLGLFQESSTSERPTASHINRCISLLNEIEATTDLGRPVTAEAFTPKTQRKLASSVPPRPMVAIARAISFPFFRQLVSDISAAFHLLDISFSADLLVAYHHFMTQENQPAVYVRSLVQAFLYLDNSVLGHSTSKEFVLQDMRTLVFPVHPLTCSTPSEIFTDEQFDTKTQFDMFVERTAESYLNLFRAFCLNRPRVRRTMCHAVLEWDQIQLEAEDLDGLIQTTFDEQAIPYAESGDDQPTFSFSLSSWVYHYKLIQLRTIVQMGFELSIYAPHEFKLMYWYLSFLCTTHMSHLERISHFVSSSLSTTARPSQHRQRQQQQQQHNRQRQQETIQKTLRHLYRLFTWLKATDSLAKSLHRVFVILDRQKLLAKPAFPYSSDTLRYEVRMRPFRHLSIPQPITDDVARQASSLDGLSDEEILEQAAAMNQISRRAWEEVLKNSWHLDPLRPSQQRDRDKGTDTGMDVKSPPAPQPQQEAQVVEHEWTRDVKNSMKSCIGTGIALSALTKALKDGRGTIDPAKIKLELPVMGDRERWHFAWVVPRIRAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YBX8</accession>
    <name>A0A0D1YBX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_09708</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232647.1">
        <property type="nucleotide sequence ID" value="XM_016384024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YBX8"/>
    <dbReference type="STRING" id="91928.A0A0D1YBX8"/>
    <dbReference type="GeneID" id="27336791"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09708"/>
    <dbReference type="HOGENOM" id="CLU_076902_1_1_1"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="93"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW12431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="227" mass="22262" checksum="6AAFA884F7C0E66D" modified="2015-04-29" version="1">MSNKQGKMQNLINYRMRVTMKDGRQMTGQMLAFDKHMNLVLADTEEFRKVKRKQNRSGAPPAPGSAAAAAVEAEEKRTLGLVILRGTNIVSCSVEGPPPSDPSARLGQSAPGGAPSALQAGVGISKPAGRGLPVGLGGPAAGIGGPPPPGGFGFPPGGFPGGAPPPGFGGRGGPGAPGGPPPGFGGPPPGFGGPPGGPPAGFQPPPGFQGGPPPQGRGFPPPGFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YH57</accession>
    <name>A0A0D1YH57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234512.1">
        <property type="nucleotide sequence ID" value="XM_016381410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YH57"/>
    <dbReference type="GeneID" id="27334161"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07078"/>
    <dbReference type="HOGENOM" id="CLU_036005_0_1_1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="66"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="374" mass="42254" checksum="94C32753CC2F4684" modified="2015-04-29" version="1">MAHLQARNHVSPDSGFPITIHPAFNPKIKAHTPPEPLRDEVFPDKDRASFADPEKKALFSVAKRVDLTESIGTVLENVQLSQLNDAQLDELALLVTERGVVFFRDQDLTTDQQVKLFEHYGTLDRHPAQKEQQHVIIKGSREDHREILTYTPWPSGDFHADTSFEINPPSYSLLRMEEHPDVGGDTAWVSQYGLYDALSKALRSFLDGLHAVHTSRLQYDTILDLWGVGPNRPPIDTHHPAVRTHPVSGLKALNVNPGFVTGFAELKKKESDKLLEFLEYHIHSADDHYVRWKWAVGSVAMWDNRCTLHRVIPGTYEGPRKGIRTTVFGEKPYFDPASESRNERALRLKTLATDGIARNDKGKEPKWDGADVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIZ1</accession>
    <name>A0A0D1YIZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235122.1">
        <property type="nucleotide sequence ID" value="XM_016382020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIZ1"/>
    <dbReference type="GeneID" id="27334774"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07691"/>
    <dbReference type="HOGENOM" id="CLU_099905_0_0_1"/>
    <dbReference type="OrthoDB" id="4725912at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="226" mass="25186" checksum="CF52A24CED54C35D" modified="2015-04-29" version="1">MEYKHDIPQSSENTSLPASLQVDFSWKKGRSIITDKANPSAPIYNVHYGVIKSPSLTFKSADDKEVIGTGTLHAVSINAKYEVHGRAGTLKALARLKTRYTHLSYAYSDDPETPVAMNWTSSCGLKNWDFICLDEAQDPVAKFSINVWALRKFGQFEFLGEKASNSVALRDELVVTGFTLFYLMYLRTNNIFSLVGAAIAKPGPIDIEKEKEKQKQKEQGEAADVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJI6</accession>
    <name>A0A0D1YJI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_05181</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235352.1">
        <property type="nucleotide sequence ID" value="XM_016379525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJI6"/>
    <dbReference type="STRING" id="91928.A0A0D1YJI6"/>
    <dbReference type="GeneID" id="27332264"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05181"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF4">
        <property type="entry name" value="D-XYLULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="10">
        <location>
            <begin position="79"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="9">
        <location>
            <begin position="231"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW15136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="46274" checksum="AFE35B49F5608DFE" modified="2015-04-29" version="1">MSPSAVVTDPQRITNGYSIVPGKPVDANQIKAISTELESSVSNDTTTAHRYGHYKNPSLYVTPSHEIRMEESSIQPPSPTEVLIHVRATGICGSDVHLWHRGAIGPLRVDHAHVLGHEASGVVLEIGTAVNHLKPGDRIAIEPQVPCHTCFLCTSGKYNLCESVRFLGVCNGGTIRRFMTHEARYCHKIPDGMTFVQGALLEPLSVNLHAIRQCEGSISVGKPVLICGAGPIGLIALASVRASGAWPIVITDIEEARLDFARKFVPGVKTYLVQPSKTPLACAEDIRLMFGCTGSRDVEKGILEVNEYSAPATVLECTGIESSVITAAYACRRAGIVMVIGVGRSLMDKLPFMHLSLAETQLRFMNRYNDTWPAGINALSNSQVLNLDGLVTHKFPLERATEAMKLCADPSQTSIKVMIVDDQEIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YK73</accession>
    <name>A0A0D1YK73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235597.1">
        <property type="nucleotide sequence ID" value="XM_016379770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YK73"/>
    <dbReference type="GeneID" id="27332510"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05427"/>
    <dbReference type="HOGENOM" id="CLU_022947_0_0_1"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="120"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="728" mass="80225" checksum="FD7CB1AD218372FC" modified="2015-04-29" version="1">MSSLHSALKALAPCDWSDIPQDPDELDPFLADLFSQAQTVIESIPIPDPEPSHRHRAQTTGSIASSASEIRPSSARSPPPPSEYAALQKEWGKPIKLSAKENPLGISVYKASSKDGKGSWFARRSVHEGLGFSRFKRGFEREFPTSLAVQGAPGEGNIRGIGADQKVEEIGVPNRGKVEVYRLSAQFPGPTTPRDFVTLLVTSSKALKQHDDSHELPPRHYMIISKPCNHPETQPGNGFIRGQYESVEFIREIPRKLKTSTSSTDLSHLGRHEESLEKEVSKQSAEKHQTSDHLHDNQHLQVDTHGSLGRDLSPGRKRGATVSAALSSSPTPHSNQQYDPEDHPVEWIMVTRSDPGGSVPRFMVERGTPGSICADALKFLDWACQREEADDFLDNSPSRPHGHRKESFASWEANGTLAGVREHEEASTPKAEAVDSERLLPSSSGLVATVAETLKHNTPQVVKDHIPNFPPLTSPASEATPAESQHSQSNEDQDNDDASSTVSTLSFASADSHLTSHVTSDEDPSISSKSLSENTTESQLVSQHDKELAKLAERKAALDSKFAQQREKLSSQASKHHEKEHEAVQKAHVKHAKELKKHEEKYEKEVAKLEQKKKKQAKKLAEKQRKQSEKDEKVRLTRERDEARAEVEILKKEQEIFTRQIGELQKENTALMAHIGKLESGLTPDGGGGGGLSPLRLRALTVGHENRNRSSSILNRLKNKSESGNEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YL74</accession>
    <name>A0A0D1YL74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236012.1">
        <property type="nucleotide sequence ID" value="XM_016380185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YL74"/>
    <dbReference type="STRING" id="91928.A0A0D1YL74"/>
    <dbReference type="GeneID" id="27332929"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05846"/>
    <dbReference type="HOGENOM" id="CLU_021768_6_0_1"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="421" mass="48962" checksum="3C1A8BD59EA1CFBD" modified="2015-04-29" version="1">MKTLSAGNEVPDDLDYTDPTRKYKNLEFLEHRNMWFFARHFDGPDRELCWSCGWNTRNQKYSFYGSRVRVMHTRANTGIWALGTRWILRDEPNDRYLGNNYMTLKFLHEQPGSKDSIPTPQEVRSLSKPGDPIYLTLESRVPGDTLMEVWPSLSREEKASYSRQLTDILRKMRQFTAPRPQRVDGSQLNDNILGVCLMSRPGNCFKIPYSVDEWLDGLGPDLRIGLTRVHNTLDPAVIEEKFQALKAGFPSCEPYVFTHGDLNLSNIIVKDGKIQGIVDWEHAGYYPWWAERRATDRIPNDDAYELFDPVWEELMPDIDRKKWVELVYHKLFPAEQAWGHCDHGHPGVDTVWWRPSFCECHPVQGEFRAHHWGMPLSCEVNQLNAGQQALLDRYRRKDPWAQEHDEKDARTLPAGEGDDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YLH2</accession>
    <name>A0A0D1YLH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin prenyltransferase PAD1, mitochondrial</fullName>
            <ecNumber evidence="6">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PAD1</name>
        <name evidence="8" type="ORF">PV08_05931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dimethylallyl phosphate + FMNH2 = prenylated FMNH2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="6"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236097.1">
        <property type="nucleotide sequence ID" value="XM_016380270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YLH2"/>
    <dbReference type="STRING" id="91928.A0A0D1YLH2"/>
    <dbReference type="GeneID" id="27333014"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05931"/>
    <dbReference type="HOGENOM" id="CLU_074522_3_0_1"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000001">
        <property type="entry name" value="Flavin prenyltransferase UbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004685">
        <property type="entry name" value="PRK06029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="7">
        <location>
            <begin position="81"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="166"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="271" mass="30179" checksum="53A5945E4BD8E579" modified="2015-04-29" version="1">MFKIDALKSFVRANAHFAIQATFTKRYMRCSSVKQQLHDFKVQGKGEISSLKAQLSYEAAVALPTPEVIDEAVSLMPPRPKRIVMGITGATGAIYAIRMLEMMRRLNIETHLVISKWAMATLKYETDLSESHIRSLATASYTAKDLSAPIASGSFQHDGMVIVPCSMKTLAAIRIGFCDDLISRAGDVSLKEGRKLLLVVRETPLSDIHLDNMLTLRRAGATIFPPVPAFYTQPKDLDDLVNQSVGRMFDALGIFVDSFHRWNGFERQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMP8</accession>
    <name>A0A0D1YMP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236537.1">
        <property type="nucleotide sequence ID" value="XM_016380710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMP8"/>
    <dbReference type="GeneID" id="27333455"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06372"/>
    <dbReference type="HOGENOM" id="CLU_674445_0_0_1"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="2">
        <location>
            <begin position="90"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="408" mass="46575" checksum="53487002940F2829" modified="2015-04-29" version="1">MSGGAFESTTQDFRPSQDRRYQPGTDDSIPGKPELKVINAEVVKSFIEDKANQAKQRHEWLRFKWLPKTVESLARFTFNIRDLVAPLTSLNPECAVVLGCLMVISKTIVLKQEKLEAVSEIFARLVQVTDSLDLCNVSVSSSPDKIRLQLAKVYIAILELVALVTEYCAIGRTSKIVDALTANTKYDFRKGLQEVESAWETLRFLMQAASSVLQIDTYDLLQDQAKKVNYVASELLIMQSQIASLRLSIDTLQLDQRRMHMLQIRQHNSVLINTLLPLYVTMDKEIQLWKGRQFRTSPKDHWEVNGVLDYLKAWNCLPHASILAIFGPTRGRDSWVTEFALDTIQAFQVQNELVTFIMCDRSEVNQYVPATLIKILICQILEQRPTLILEEPDLFLLHNFQSAVELNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNT2</accession>
    <name>A0A0D1YNT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236992.1">
        <property type="nucleotide sequence ID" value="XM_016378315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNT2"/>
    <dbReference type="STRING" id="91928.A0A0D1YNT2"/>
    <dbReference type="GeneID" id="27331049"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03966"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05198">
        <property type="entry name" value="formate_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="28"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="122"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39137" checksum="8ECA703194D9FFAD" modified="2015-04-29" version="1">MGSTSASQSATVKIVALEAQFGPIPEFDDFNGKYEITIYDVTPRNDVKVLNERIGDADVAIITTMPMTAATLAPEVTPNLRAIMVMAAGTDHIDLEYCRKRGIRVLNSPRANTTTVAEHAVALYFAVRRCVVQTHVRTVQDQWPKHRTLLSSLRDKDNRLPLGLKDEVAGIIGYGGVGKHIAKLCSALGMSVMIADRKANSTQKHHASPPASTNGSEVTRASFADVLAKCTAIFVAVPRLPTTLDMISATELATMNGRAVLINVSRGGIVNEADLVSALRCRQIAGAATDVFLTEPASTENSVLLKALAEEDVKKDEEKLPLVVTPHTAWYSEVTMENLVEDVRTNVVGWSRGVLPPENLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YR42</accession>
    <name>A0A0D1YR42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237942.1">
        <property type="nucleotide sequence ID" value="XM_016379265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YR42"/>
    <dbReference type="STRING" id="91928.A0A0D1YR42"/>
    <dbReference type="GeneID" id="27332004"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04921"/>
    <dbReference type="HOGENOM" id="CLU_006598_1_0_1"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000601">
        <property type="entry name" value="DNA repair protein Rad7, protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056451">
        <property type="entry name" value="Znf_Tbcl_Rhp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23550">
        <property type="entry name" value="zf_Tbcl_Rhp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair protein rhp7 treble clef" evidence="2">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="308"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="621" mass="69520" checksum="39222578A2E8239E" modified="2015-04-29" version="1">MPILNPQLTRPRANRRNNNPAANRIRGPQSALTDFLASHNISAAQIHNDYQRRVQEAERQAQQDAQNARNSTDNKENEDEEDEEDVVERQKRKRKEEKALLKIKQSKEFKRRKHEQDEDFRQDDDELARSMLAKSKPLPGQLDNCEICGKRFTVTPYSGTGPDGGLLCGKCSKELKDEKKKEAKAAKKKTPVSRGRRRQTESDRMMGDVKPGAKSLLDICVRHVANVAHDIDEFGDMPQYLLDRLSQIFSKQRVITPRVLELFLRPDVDRINVYDCGKLETDDFQKIFAFMPNLETVNLRFAGQLKDGVIKYMADKCKKIRHLQLGATNLVSDDAWIELFRSLGPQLESLKLSELNDSLRDDTVKELVKNCPNLKRLKLRSCSYVTEESIDAFCALAKLEHLTLAVAQDTSADTLVKLVSSLGPHLRTLCLEDFSELDDAVLDAIKSNCVKLSKLRIRGSSLCTDAAFAGLFDNNCPFPPLVYADFADNRDIDSMNPEGPQDNPVGFGSLALTALMNHSGPRLKTIDLKSCRHISHAALLEAFDGLKKYPAITDIDLSFVTQVDEVVLVGIFKSCPSLAKLAVFACFNARQAVIPSGIAVIGLPNAQDNIVREGDVQMILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRB2</accession>
    <name>A0A0D1YRB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04991</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238012.1">
        <property type="nucleotide sequence ID" value="XM_016379335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRB2"/>
    <dbReference type="STRING" id="91928.A0A0D1YRB2"/>
    <dbReference type="GeneID" id="27332074"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04991"/>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_1"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="83"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="513" mass="55390" checksum="75478D206EBCFD30" modified="2015-04-29" version="1">MATNGDLPSDDEFSQPGTPPGDENDVEEIEETNQPPKSALKKGTTASIPEPQVTRPPLPEQPDPANLDISKLTPLSPEIIARQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLGYANAKIYKCDNPECPRPTCYKSFKSEKEVDPPCERDGCGGTYRLLRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNEACPQPQTSEHLAAIEIMKLSHIIILQNKVDLMREEGAQQHYESILKFIKGTVADGSPIIPISAQLKYNIDAINEYLVTKIPVPVRNFQAAPHMIVIRSFDVNKPGAEIEDLKGGVAGGSILTGVLKLGDEIEIRPGIITKDATGQTVCRPIMSRVVSLFAEHNDLKFAVPGGLIGVGTRVDPTLCRADRLVGHVLGLRGNLPEIYMELEVNYFLLRRLLGVKTADGKQAKVAKLAKNEVLMVNIGSTATGAKVMGVKADAAKLTLTNPACTAIGEKIALSRRIEKHWRLIGWANIVAGNTIEPEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRV4</accession>
    <name>A0A0D1YRV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238177.1">
        <property type="nucleotide sequence ID" value="XM_016379500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRV4"/>
    <dbReference type="STRING" id="91928.A0A0D1YRV4"/>
    <dbReference type="GeneID" id="27332239"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05156"/>
    <dbReference type="HOGENOM" id="CLU_096750_0_0_1"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33930">
        <property type="entry name" value="ALKYL HYDROPEROXIDE REDUCTASE AHPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33930:SF2">
        <property type="entry name" value="BLR3452 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="166"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="264" mass="29557" checksum="0E86B858D9F69309" modified="2015-04-29" version="1">MSQSTSDDRVSALKCRFEDQRGIWSPAWESVAKLNPGYLEGYLKIQWASQHRNRLPPKIQELCYIAVASSVTHMYLPAVEAHILAALRTGATSEEIFEVLGLSYLLGVHTVTMGFPILQELVEELSIPADTVTPEQQELKEIIKSRFIATRGFWPETFKPLLDLDPEFFEQYTDFSSFSPRSKVLEPKYRELIITAIDAATTHLYSRGTKIHMRNALKMGITPAEVLEMLEITSLMGIDGVVNSAPLLAKARELVPKDGSSLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUU1</accession>
    <name>A0A0D1YUU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239222.1">
        <property type="nucleotide sequence ID" value="XM_016377652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUU1"/>
    <dbReference type="STRING" id="91928.A0A0D1YUU1"/>
    <dbReference type="GeneID" id="27330379"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03296"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30362" checksum="979FDB969F50A72F" modified="2015-04-29" version="1">MPDKTILITGCSKGGLGHALAVECQRRGMTVFATARTLSKMSDLKNLPNTTLLSLDVTSPTSVADAVDKITTATGGKLDYLLNNSGQNIILPALDLDIDEGKKMFDVNFWGVLRMIQAFAPLLIEAKGTVVNIGSIVAYLHTPYTAVYNASKAAVHMLSDTLRLELAPLNVKILTVVTGSVKTQIHQNSPRLSLPQTSRYLAVSSHLEKRWNDEIDYDPSSPEDLARKVVGDVLGGSTGKIWRGRHASETRWVRFFMPLPLQDMILTNGTDLDKVGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUY3</accession>
    <name>A0A0D1YUY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Forkhead box protein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_03361</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239287.1">
        <property type="nucleotide sequence ID" value="XM_016377717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUY3"/>
    <dbReference type="STRING" id="91928.A0A0D1YUY3"/>
    <dbReference type="GeneID" id="27330444"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03361"/>
    <dbReference type="HOGENOM" id="CLU_054972_0_0_1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767:SF2">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="14">
        <location>
            <begin position="167"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="12">
        <location>
            <begin position="167"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW19071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="405" mass="45936" checksum="80CD791B877D47DE" modified="2015-04-29" version="1">MEDDTLHCNYENYDSFDLDLPIDVKRSLSISSLPSLACDTLQAEVHQDHSFYDGNLIDQPTDGFGVRPDQLLHSRTQIQLSDLELAPTLTNLEAYPSHVHGHQGNTTGNADVDVYRYSSEIMESPFSSYQYYDESDSKSAWSIASDVNYSQPPAFLEEGEPFDDKPYAMLIYEALKQAPGHRMMLKDIYDWFRYNTTKPQESGSKGWQNSIRHNLSMNKAFENDRDSARGGSRKTNSVWVLTEDAIKNGVQSTTRYRKAGGGKRHNGHRVPAIQRQRSGAKGGRATSRAARQRRQEIPYVTSTPLTCSPATQYSDLSDYRSFDCYDYDLQSAARSWPVTVGDHQQTLPVDLVRCLSDSPPNTMQFDHQPSRLCQSHSEENLRIHSILLRPSLDQSMHESAQIHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWF8</accession>
    <name>A0A0D1YWF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239842.1">
        <property type="nucleotide sequence ID" value="XM_016374566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWF8"/>
    <dbReference type="STRING" id="91928.A0A0D1YWF8"/>
    <dbReference type="GeneID" id="27327282"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00199"/>
    <dbReference type="HOGENOM" id="CLU_028458_5_0_1"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="237" mass="26094" checksum="475BD1C7C142E7F0" modified="2015-04-29" version="1">MASIKANCRKVVCIGRNYADHITELNSARPAQPFFFLKPPSSILLPNKGPVIRPRGVNLHHEVELGLVIGETPSPEGLKNLQASDSKMLSYIKSYFLGIDLTARNVQDEAKKKGLPWSIAKGFDTFLPISHEIPFDRIPNPHDVVLWLSVNGTIKQKDNSNLMLFDIPRMMSDISKVMTLEEGDIILTGTPKGVGPLVGGDVVKCGLEADGREVVEARIEVQVVDDTTEGAYEFKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXB8</accession>
    <name>A0A0D1YXB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_00496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240137.1">
        <property type="nucleotide sequence ID" value="XM_016374861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXB8"/>
    <dbReference type="STRING" id="91928.A0A0D1YXB8"/>
    <dbReference type="GeneID" id="27327579"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00496"/>
    <dbReference type="HOGENOM" id="CLU_014033_2_0_1"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000868">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="567" mass="61251" checksum="F79F4E18E7000B6D" modified="2015-04-29" version="1">MDEDSLRDFLPTSFGGGVGGFDAQAQLEQARRKVPEAQKAKARSAAGSDSDSEDSDDSEDDDEYPISHEIVFKTHDRPVTTITVDPSGSRMITGSTDCKIKLHDFASMTPNTLRAFKSLDPTATKTSANSESHPVHAVKFNPTSPGQVLVVSATTQAKILSRDGETITEFVKGDMYLRDMNMTKGHISEITGGTWHPFLPHLCVTAGTDSTIRIWDVNVRTKQKDVIVHKSKLAGAAGRSRMTAVAWGSQVGSDNSLLVGTALDGSLSMWGGEGPYHRPSAEISNAHTSNTWTSGIDISADGRLVVTRGGDDTIKLWDTRKFKQPVNTTSHASTSSQYPTSGIMFAPNSSSIITGSETGDLYILNPATLKPEVVTAVTPGSPLISVLWHDKLNQIVTGSANAETHVLFNPKISTKGAVMVMSKAPKRRHVDDDPSLTTDLSQGISGDAIVNPGTSSEGIQGSTFSSRHPTIGLTASGKSRDPRRPHMPVSTPFARSQPDEKHIKERIPLSSMREEDPREALLKYADKAQNDPMFTKAWGKTQPKTIYADLSDDEDGEDGPQKKKQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXV2</accession>
    <name>A0A0D1YXV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisomal targeting signal receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_00676</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240317.1">
        <property type="nucleotide sequence ID" value="XM_016375041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXV2"/>
    <dbReference type="STRING" id="91928.A0A0D1YXV2"/>
    <dbReference type="GeneID" id="27327759"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00676"/>
    <dbReference type="HOGENOM" id="CLU_013516_3_0_1"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000218">
        <property type="entry name" value="Peroxisomal targeting signal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="9 15" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="198"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW20101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="644" mass="71084" checksum="352BC08D1D4999D3" modified="2015-04-29" version="1">MSFLGGAECSTAGNPLTQFTKHVQSDNSLQRDRLVGRGPGGLEEGMRSRMAPNGSDQMMNEFMHQPGQLPQPFAMEQLRQDLPNLQSMTRRSPSPGWAAEFDPGEQARMEAAFANSKMAQAPQRPGAFSPQEFGRFQQSSPHRTASPVTQAPSLYRPLGMGYMNGGMGMGMNYGAQYMQHQPDQTTDKGKGRMVELDDANWEAQFKELETQQDSLSEQANQAMEQELEEIDRSVAAPIDTFEDFENVWHGIQAEHSSRQMSDEAADFETAFSSEDYAAWDQFDSTMGLGTHNPFEREPMLGDYMFEQQNPYLENQSASRTAFEQGLEILEAHGNLSLAALAFEAAVQQDPNHVDAWVLLGAAQAQNEKEAPAIRALEKALQLDPNNLDALMGLAVSYTNEGYDSTAYRTLERWLTVKYPGVHPPENLSDASEVGFTDRAILHERVADLFIKAAQLSPSGAQMDPDVQVGLGVLFYGNEDFEKAVDCFRSALESTEMGLANSNAQIHLLWNRLGATLANSGRSEDAISAYCKALEVNPNFVRARYNLGVSCINIGCYPEAAGHLLGALNLHRVVSEQGMDKAREILGDGDGGIGDAELERMIQQNESTNLYDTLRRAFTGMGRRDLTEKVGAGMNLDQFRGEFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z1N9</accession>
    <name>A0A0D1Z1N9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241772.1">
        <property type="nucleotide sequence ID" value="XM_016376496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z1N9"/>
    <dbReference type="STRING" id="91928.A0A0D1Z1N9"/>
    <dbReference type="GeneID" id="27329219"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02136"/>
    <dbReference type="HOGENOM" id="CLU_000288_138_13_1"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="603" mass="68636" checksum="7E79E28AF954732D" modified="2015-04-29" version="1">MRLLNCRTLQLEWFADDSIPEYAILSHRWDKGEVEFKDMRHLSKARRKEGFAKVRNSAKRAFKKHEVEYIWIDTCCINKDSSAELSEAINSMYAWYKNSTVCLVYLSDVPGDEPITSNSRFGGSVWFTRGWTLQELIAPERVEFYRSDWSSCGTKQDLQKVVACITRIPESVLGDGNLEQYSVAQRMSWASDRETTRVEDVAYSLIGIFDVNMPMIYGEGKKAFMRLQEEIIKRSSDQSIFAWTNARNKPTLLAPSPAYFKDCDDVSYGSHFASSGHLNPYALTNTGLEIHLALLAWSLDVYVGLLGCSRMPKRAKKGRRMSIGIFLFYSDSGRYYRTTFEGLRSISFEDSEMRAFLSGGQVIHGRTVLIHPTIVRNFNCLYGFRIKQGIPNGFWQVASAKANLLAHHWDAESGEVSIDEGTAGTVAVIFFDGLFDSFGQTTFMQLAFDDYFNPCCLIGRCDRDQFNSFRFAIGQSDMLRAYPRRPSPRSPGDREKFPKASWAKEEDGWAVAIGNWKTKKVDVSGRGMCHAYKLTTRTQLFPPKFDLLKTAFPGVYIAFDRFWRSGLKTPRSWQFIYHFPDAPVDAGNHRLVHSSSTPALLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZB46</accession>
    <name>A0A0D1ZB46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional repressor Tup1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_11209</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230463.1">
        <property type="nucleotide sequence ID" value="XM_016385519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZB46"/>
    <dbReference type="STRING" id="91928.A0A0D1ZB46"/>
    <dbReference type="GeneID" id="27338292"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11209"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_23_1"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000111">
        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF728">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR TUP11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="439"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="484"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="539"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="581"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW10247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="624" mass="68000" checksum="526CF21CD7670F48" modified="2015-04-29" version="1">MFNATQHRGNPNLGPAPPGPPNHRLNEIFDNLRAEFENQSRSSEQVENQVAQQIQEMELIRNKVYQLEQNQLKMKQDYEAEIRILRHELEMRGGSQVQSHIGGPPQHSGPPAQAPPSLGHGQGGLFSGIMANQGQGGPGLAPPPEQAAPQQHPLQPPPPAGQPQGPPQGPNAFPGYQQPPALNGYGPQGQPPTNSPGLGKNRNMTTRGGPGPATPQQHPGQPQPMPYQNDPRASPQIPRPTPPGSDMQLGPRHQMAGQGQYPNVGNVLADLNPDELPDHLKRMGANGEWHAVFNPNVPRVLDITLLHNLVHESVVCCVRFSNDGKYIATGCNRSAQIFDARDGRKVCELLDENVQDKDGDLYIRSVCFSPDGKLLATGAEDKKIRVWDIESKRIRTIFDGHEQDIYSLDFSRTGRLIASGSGDKTVRLWDIESNQQVMVLSIEDGVTTVAMSPDGRFVAAGSLDKSVRVWDCSSGYLIERLEGPQGHKDSVYSVAFSPSGRELVSGSLDKTIKMWELSAQRGIIPSASNGKDGKCIRTFEGHKDYVLSVCLTPGGEWVMSGSKDRGVQFWDPNTGNAQMMLQGHKNSVISVAPCPTGHLFATGSGDMKARIWQYTTWRGAHQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZGH1</accession>
    <name>A0A0D1ZGH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_09336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232278.1">
        <property type="nucleotide sequence ID" value="XM_016383655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZGH1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZGH1"/>
    <dbReference type="GeneID" id="27336419"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09336"/>
    <dbReference type="HOGENOM" id="CLU_062674_0_1_1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075:SF1">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="114"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW12062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="360" mass="40656" checksum="7AF50AE190545550" modified="2015-04-29" version="1">MFRSIVARPTVLRPSIVLPSSIPIRRHLHLAPPFLLEDYIPRYHLISSVDASRKRSAAYAHLRRCNLCPRLCDVNRFETTGHCLIGAEKVKVGTIAPHFGEEPCLQGHHGSGSVFFSGCNMRCVFCQNHDISHQKVGFDLTPDELAEWMVKLQEVGNVHNINFVTPEHVVPQVALAILAAREMGLRVPIVYNTSAFDSLQSLELMDGLVDIYLPDFKVWHNETSKRLLKADGYADVAKESIKEMYRQVGDLCFTGDGIAKKGLLVRHLVMPGKEEEGVRIMQWLAEALGKDVFVNIMEQYYPTAHVGQERRGAKTNKDEKRYSEINRHVNKDEIGIVQKAAREAGLWRFAEPARHGGWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZGH9</accession>
    <name>A0A0D1ZGH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_09346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232288.1">
        <property type="nucleotide sequence ID" value="XM_016383665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZGH9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZGH9"/>
    <dbReference type="GeneID" id="27336429"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09346"/>
    <dbReference type="HOGENOM" id="CLU_065428_0_0_1"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002247824" description="Cytochrome b561 domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="41"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW12072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="296" mass="31982" checksum="34F153C2FBF3DCA5" modified="2015-04-29" version="1">MSFTRTLLSTALLLTTARADWSGFGGRNGNGGYPWSNGDDDGGDGGSSSSGSSTFGQGSVFSSAGQFDRATHILIAHAVLASLVWVLFIPSLAILLRLNIKNPIVLRIHAVGQVLSYVLYIAAAGMGIWLAEQFKDFGVWDDPHPRMGLAVLALAFFQPVFGYIHHRIYKKRALKVEAGQPTKAPGRTPAGRAHLWLGRILIVLGIVTGGLGIKLASESPLQTDSQSRTAKIAYAVVAAVMFALYLFFVVAFEIRRARQVGQDRQTRADAAARKETGALPTYDESEESVGRSTRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZLQ1</accession>
    <name>A0A0D1ZLQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233983.1">
        <property type="nucleotide sequence ID" value="XM_016383280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZLQ1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZLQ1"/>
    <dbReference type="GeneID" id="27336041"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08958"/>
    <dbReference type="HOGENOM" id="CLU_094004_4_0_1"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="152" mass="16934" checksum="29AACD749E72E7E4" modified="2015-04-29" version="1">MPVSGLSVNPECVSAFNELKLGRGGPKYIIYKISDDQKEIVVDEIGKESDYDTFREKLISKKEKTGKDRPSYAIYDVEFELEGGEGKRSKIAFITYINQDATGVKSRMVYASSRETLKNALNGIAMNWQANDPGELEWADLLKEASKGKGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZP92</accession>
    <name>A0A0D1ZP92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_07406</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234838.1">
        <property type="nucleotide sequence ID" value="XM_016381736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZP92"/>
    <dbReference type="STRING" id="91928.A0A0D1ZP92"/>
    <dbReference type="GeneID" id="27334489"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07406"/>
    <dbReference type="HOGENOM" id="CLU_055657_0_0_1"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000026">
        <property type="entry name" value="Gamma-cysteine synthetase regulatory subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="11">
        <location>
            <begin position="69"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW14622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="305" mass="33942" checksum="E9FDF42C4F544D01" modified="2015-04-29" version="1">MSSGQSIVRRPLFSKSNIELINSLRSNFASFQHNHSSETTDQTLDYKQWTTEENDILYVPSWRPTPLTEPRESYDVTVKLFFLPGIPSTRRCKHTEEAIDLVLKELGIENIDLLIVSYPGVTFDADDEEEVSADEDESARSDESEGLDAQIKTWQVLESLHEKGVISQLGVSEFSSERLDKFLPEVKVRPTVDQINVKDCCVVPKSLIMYAKENKIELLTHADCMDILPPGTTRELLGPSKDGAGILAACPDAGADEPGLKGDIEPQWVVKYTAVVKNRGVVENKGYFAVAQLGNCIEQKPDEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPR4</accession>
    <name>A0A0D1ZPR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_07592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235023.1">
        <property type="nucleotide sequence ID" value="XM_016381921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPR4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZPR4"/>
    <dbReference type="GeneID" id="27334675"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07592"/>
    <dbReference type="HOGENOM" id="CLU_069858_2_0_1"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW14807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="222" mass="24812" checksum="9293C4A44D16D110" modified="2015-04-29" version="1">MHLRVRVLHQGAGARVCAACTKAEHQLPSGSTLKRCGRCQKATYCSKECQTSHWPQHKNECPRRGPTAAAAAAAGSNGGNGNAPHPRLVDYFRSLDSETKTYQMLIDTFRLRCEDDYTWGQHNHGIYGGDPPLPVFRDFLARARAAGMLPAWWNQEKQTACERVATTDDHFNIAYSVEKSDIQDHYSDPMMPMMLRMVAENVYGGGYGLGQRPMPENYVCQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZR84</accession>
    <name>A0A0D1ZR84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235538.1">
        <property type="nucleotide sequence ID" value="XM_016379711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZR84"/>
    <dbReference type="STRING" id="91928.A0A0D1ZR84"/>
    <dbReference type="GeneID" id="27332450"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05367"/>
    <dbReference type="HOGENOM" id="CLU_013866_3_0_1"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="580" mass="64633" checksum="89EFA99895C77455" modified="2015-04-29" version="1">MRELQEAKVRTGCFAVHAARSCDAHAFCGSRFRHNLLTICRHQCPGYRDLFDALHKDETPIVAQTKKPPKKTPKIEAAHSPSTTNEELDLHEIMTASSASPIPTGPVMILIEPSRDAQAECLSYFFSNYVNIPRDPSTNIFIEHILPLYLNAPVNSALVQSVHAVAINVTQMWVSRNMDSYLARETYASAVSLLKTALADPVESKSDDTLAAVFLLDFYDSLNKRFVGFIDNGTHQQGAVALLRHRGKENFKTPTSQRLLTALRSRHISFAMQAGQKVALNEDLLAEETAVLPSAKLDLINAELADLHVVAAEGAQAMNMTLVEFYETILRKALAIDKKLQAWREALPKSWLPVAVPSSELHPSIRAAGVYGDTVDVYSSLTVSHVNNASRSSHVGALRLMALCKQELEALGVDVDPRLDSHLKSRTQEITDRFCASLPYHLGNRTTLRFPHEHSEYPHVPEELRKLANYVDPFGNPVEMTQEDHIRAAAAIGGWFVMTPLIGFLKSPVLRWPHNKPGPLVRTLRPGQLDWIRGQMHRLQKIYGLPTIPMAFSSPSPDIRLPSPAQTVYPTILNRQIWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZRR6</accession>
    <name>A0A0D1ZRR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235673.1">
        <property type="nucleotide sequence ID" value="XM_016379846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZRR6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZRR6"/>
    <dbReference type="GeneID" id="27332586"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05503"/>
    <dbReference type="HOGENOM" id="CLU_101888_0_0_1"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="193" mass="19991" checksum="8E880CDE7E5D4283" modified="2015-04-29" version="1">MANVNWRTINVDAYDPESALNFPMTTLLPANLPAPSTSAESAQIGQQVRQLLRAGDSLGALQSALETAPFAGDESAKQVHLTTVLEVLQGIRQSDVSKLLAEMLGQPGGTALGDTLMKYIYKGMASGAGGSGSGGKGVSPQATGSGFSQIQSRNFGEGGGGQVMSVLLSWHEKLTEVVGVGGIVRVMSDRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZRY2</accession>
    <name>A0A0D1ZRY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05563</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Also plays a role in mitophagy and regulation of filamentous growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235733.1">
        <property type="nucleotide sequence ID" value="XM_016379906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZRY2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZRY2"/>
    <dbReference type="GeneID" id="27332646"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05563"/>
    <dbReference type="HOGENOM" id="CLU_027589_1_0_1"/>
    <dbReference type="OrthoDB" id="21072at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2570:FF:000001">
        <property type="entry name" value="Autophagy-related protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="416"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW15517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="504" mass="53469" checksum="033F157E12FAFA13" modified="2015-04-29" version="1">MAQIEHHFTVFIRLPFNRGDFIDPPPVAWSATKESALWNIISRQSKGNEIDWRSLSEQFEVSQSFLLQQAAWLYERQLSQVRAQMRRVGGRQSATPSPVPGSVSASMVGGQAMKRAGSGGSRVPSRLSTQAAGSPIATGGDSVPGTPGAKVRTFLPFRSASNQGAGPSQPRVPPGSSRPISRQSFKDDPLTHTSHSRRGSMQHQVVRSPVPQRTPQPQSSDSEDEMTQSRIAARRPNPSAIHRRALSQRQSQRISSEQAQQAAAASDDDNDDDEDDEPSFLPFATPNSNTNTNEAKPSGASSSQQDPSATLRGNLHVHTPGSPATTGRPNVIRRITSERVSSPTIEPPTPIAPARKQDTASSTSSLSSPTNMSREPSSMAAPQPPPPASGQQQSQSTATNNPRLGNPLSPPHRALLQSSPRRGPGSDTSPSMGSSFSDLDDASVTQSALEEALLSGMGNTTMTMPGGGVAGRVSGISQALRSRYFEARGEGQRGGGGNNGVSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZRZ1</accession>
    <name>A0A0D1ZRZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MMM1</name>
        <name evidence="12" type="ORF">PV08_05580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235748.1">
        <property type="nucleotide sequence ID" value="XM_016379921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZRZ1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZRZ1"/>
    <dbReference type="GeneID" id="27332663"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05580"/>
    <dbReference type="HOGENOM" id="CLU_032730_1_0_1"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="32"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="111"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="348"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW15532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="427" mass="47308" checksum="C09BACD02B00B640" modified="2015-04-29" version="1">MSSDLTFTQGLILGQVSVALFIAAFIKFFIFGEPPPPPSRSTTRTPKHVRTPSLHSVASSKTAVSQSLRNKASSNVLRPVPNNATDIASILRKTYYHIPNRPHKNSHSTHQPESLDWFNVLLAQTIAQYRQTAYNLREGTGSTPTILASLEEAINNPDKRPSYIDKIKITEISMGEEFPIFSNVRVISIDDDGSSSTGGRLQALMDVDLSDDNLTLAIETALILNYPKPFSAVLPVALAVSVVRFSGTLSISFVPATQDDPDDGNSKKNGSTGKPKTNLAFSFLPDYRLDLSVRSLIGSRTRLQDVPKIAQLVEARAQAWFEERVVEPRVQVVPLPGLWPRMGKVRVREGQDDDRPSTQDEHRPASFVERRDPRPTDDFPSQEETERIFEGLRRRTGRDRSNSQVFEHDEDSAAPQSAPTMPGALPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZV15</accession>
    <name>A0A0D1ZV15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236763.1">
        <property type="nucleotide sequence ID" value="XM_016378086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZV15"/>
    <dbReference type="STRING" id="91928.A0A0D1ZV15"/>
    <dbReference type="GeneID" id="27330818"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03735"/>
    <dbReference type="HOGENOM" id="CLU_007383_12_0_1"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="350" mass="38540" checksum="2097BE11BF1074C5" modified="2015-04-29" version="1">MSESTPRILVTGATGYIGGSVLSEILQSPAVEAGSVSALVRRPDQAEVLLAHGVTPVLFKHLDDLETMEKVARDFDVVINCANGFHASSAVALITGLSKRKEKTGKQVHFIHTSGTSNLGDYRISGKYKENRIFTDKDHIFAYEKYREDMETYPQRTTDIAVVETGLATSVRTYIIMSPTIYGFGSGWFNTISIQIPALIRTAIEKGHAEVVAAGNAKWNSVHIADLALLYEILLRGVLEGRKLAYGSQGIYFSETGEHSWLDLAEGVAKAGFELGVLEAPAPVSITLQQSAQQWGKGSLQYGELGWASSSRTRAVMSREIGWKPTKGRRDFEENFSEEFQLIFNRSKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWV9</accession>
    <name>A0A0D1ZWV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04368</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237393.1">
        <property type="nucleotide sequence ID" value="XM_016378716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWV9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZWV9"/>
    <dbReference type="GeneID" id="27331451"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04368"/>
    <dbReference type="HOGENOM" id="CLU_072439_6_0_1"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="151" mass="16282" checksum="9690A14C92944449" modified="2015-04-29" version="1">MPPKKRVERPANENISLGPQVREGELVFGVARIFASFNDTFVHVTDLSGRETICRVTGGMKVKADRDESSPYAAMLAAQDVAQRCKELGINALHIKIRATGGNGTKTPGPGAQSALRALARSGMKIGRIEDVTPTPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYG8</accession>
    <name>A0A0D1ZYG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_04897</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237918.1">
        <property type="nucleotide sequence ID" value="XM_016379241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYG8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZYG8"/>
    <dbReference type="GeneID" id="27331980"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04897"/>
    <dbReference type="HOGENOM" id="CLU_015857_2_1_1"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF15">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="13">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW17702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="402" mass="44494" checksum="C13EFA7E4B455BC7" modified="2015-04-29" version="1">MDQAAEQPRKCPGLNCENDASTLQCPKCKEMGVDSFFCSQDCFKRSWAEHKTLHKSTNPLRNFLVPSVVSKVDPESGHFNPFPTYPFTGSLRPVYPLSPKREIPKSIPHPEWSQDGIPRYPYVRKNNIQVLDEKGIAGMRKVCRLAREVLDIAAAAAKPGVTTDQIDEIVHNACIERKSYPSPLNYNHFPKSVCTSPNEVICHGIPDQRVLQDGDILNIDVTLYHEGYHGDLNETYYIGDKAKADPDNVRLVETTRQCLEKAIEHVKPGVKIADFGDIIEKHAKSQRLSVVKTYCGHGINSLFHCAPNVPHYAKNKAVGKCKAGMTFTIEPMICLGQHKDKTWPDDWTAVTSDGSRSAQFEHTMLVTDDGVEVLTARLPNSPGGAIPMPSPNGEAAHTNGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYS8</accession>
    <name>A0A0D1ZYS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238038.1">
        <property type="nucleotide sequence ID" value="XM_016379361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYS8"/>
    <dbReference type="GeneID" id="27332100"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05017"/>
    <dbReference type="HOGENOM" id="CLU_023417_3_0_1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="474" mass="54367" checksum="9B1A50FC6293B400" modified="2015-04-29" version="1">MGCRRRNRKKKCDEARPECLRCKTLGLRCEWPTAGDLVDRRCASTRTRRSVSPQEHLEPKTAGLEVTSAHRALLDPRISLFSASTTHQVLKQDLKPVISRHFMDIYYGLLILPNCHPEYYWGWIKEIQELMVQHESLQYSVLANAASHIHFIDDSSTMQELALTYYSQALRGLSELLVKASQVENHNGLLMTVMLLYLHGCLGRGTYTDIPRHVDAAIRILTLRLLESPKGISRPFDRLAVESVLYQIFLATTGSWSNPTEIEDRFDTKFWTQAEQLLSRSTLFPDRSISYNSPVLGIPFALFKLALSIKTLYQNPVGPDTQTLEEYKAELEYWECALLCDRDVDAIGGDEEPNCAPQIYKDAAFLYILNASMLLEQLMQGHHAPGPPRAHDVESWQVGKAREILKLHRNDGHWARCYIGNWPIYTLGFFMSTPEDIDLVRNELRRRWNCMQFGQIGRFATDLENTWAKRGYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYZ0</accession>
    <name>A0A0D1ZYZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238093.1">
        <property type="nucleotide sequence ID" value="XM_016379416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYZ0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZYZ0"/>
    <dbReference type="GeneID" id="27332155"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05072"/>
    <dbReference type="HOGENOM" id="CLU_103849_2_4_1"/>
    <dbReference type="OrthoDB" id="525520at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="10199" checksum="0616DDD1F85C4A96" modified="2015-04-29" version="1">MSKFYLHDTIRVGELSQNQVLDLTAHLDSMKIENHLRRQINQDIQRLRDTGTYRGRRHAMNLPVRGQNTRSQIKNARFFNRVERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZ36</accession>
    <name>A0A0D1ZZ36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_05117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238138.1">
        <property type="nucleotide sequence ID" value="XM_016379461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZ36"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZ36"/>
    <dbReference type="GeneID" id="27332200"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05117"/>
    <dbReference type="HOGENOM" id="CLU_096872_1_1_1"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW17922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="165" mass="18505" checksum="80881BC9B91403C2" modified="2015-04-29" version="1">MAPKFEQAFKLRAFLSKEDFLSLGPVKGGPHRYIATVTHGTLEGSGLKAHLIHGGGDWLLLDTSRGVAHLDIRAQARSEAGEYFYLHYPGILKVDEATHLVMQWSPEAKTTRSEDHYFITTPVFETSSQDFKWMEENVFVGHGHWVIPGDGTQAVEYEIYKVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZ96</accession>
    <name>A0A0D1ZZ96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW17987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238203.1">
        <property type="nucleotide sequence ID" value="XM_016376633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZ96"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZ96"/>
    <dbReference type="GeneID" id="27329356"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02273"/>
    <dbReference type="HOGENOM" id="CLU_657383_0_0_1"/>
    <dbReference type="OrthoDB" id="5295335at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="353" mass="39939" checksum="79A0AFF46EFADD06" modified="2015-04-29" version="1">MPMTGPLHGAALETLDTFRSNGLYLGLRRGVMLGSTFLRDTEAKNRRILSVATIEEEKECRNGIWIRVLREAKYVDRKAGTLQRDSETTAVDNRPPYRAMQLVHHLKLKYADNAEGTGATVVSEGSVSWRAILGIFVSELSSIAIAITAAVAKPFKTWWLAVYLCVPLLLKLISLLVSVRRTTIHQEKIPAASSSAPKDDLYEILDGNHSFGLIESPEITLRQFFRHYGHPIRDSGVAGRRDRAREVHSMALVYLFVLYFPAGLISSLWMPSNVQLLWLSFQVYMILVMHIVRICGWEHCGQTEGRIARLLQGNRKVFLQAKKPAKYGVIVTFGDYRPSQCCRSEERSEENYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZM7</accession>
    <name>A0A0D1ZZM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238393.1">
        <property type="nucleotide sequence ID" value="XM_016376823.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1ZZM7"/>
    <dbReference type="GeneID" id="27329548"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02465"/>
    <dbReference type="HOGENOM" id="CLU_252769_0_0_1"/>
    <dbReference type="OrthoDB" id="10582316at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1157"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1189"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1281"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1281"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1313"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1356"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1382"/>
            <end position="1400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1445" mass="158492" checksum="54E24BAC24AE73AA" modified="2015-04-29" version="1">MDLSTRGHGSPGQDSRTDDERTEDDYSSLSSLGISPVVSPRRLQRPMPAGRRDRNPTSPVSSTAGSDSGRERVAAIAQASPVLVRNIDSIAGIRSSSAELSTSANTQAICEAERSQGQDTVRHVSESISPTSNSIPLEIPADPLFVARDDYKSAIEGYEADIPEVEWQPTRSGNASPLDEHIQAGDTISALEAQIQNPGEIDREVGVASQTMPASAQQEPSGEIKRTTSTDQKKLLQKLKKVENERDQISEQMEALLSDNARLCNEVNDLTTAGHRNLHASRIRDHDLRLAVEAAEKARTEKDRSEESMLRLLEQLRKVKLENSKLEAALKGSSDEISRLKVQPEAKENESQQFNQAEGSPPTPPNKLEADATKIIPWMEKAWEQQSRIYPLLTHFHSQHLLRLHDNIWKQRMPQSMLPFPAQFENLGDLISIPSEAYASTRHSMASETAFHVPNRKDSRSMVQLPPNGTARTRSGHVCDPFRQQLQSYQREQATRTWTQAPRNAENATVGKLQQPLRMADIIAADLSKPPSRIPRLMPKNRIDKHISTSMSPPMSSSKAYLSPQPQIRLEVRSPTRLKGEDELPTAATVGKGEPSLSFQKPEDFSGAQARPSLTEDVNALQGILQSQTEGTGDREFHPSMFPSKALVSSPLRTDLEASRRTPTNHASGITHGGTSSAVELPRSLGLKQRFSCPQASARSRSLPINRLEARDVEASYSSHKGIEAPIKSVAKQTTTSDNVAENATGDEQQPVIPGEFGGFEKDKSATSHRQTLPLGQSNASPSELRHRRPYSWDGAVHRLSSTTVTMSRSNFKPLQASDGIARAYEETLIPGTVVDYGRVVKEIHKSFSSDSVEASHMTGEAVYHDINGTRDDDLPPTFSLAGVSSHSRLDNVYSDDLKAYQNQKLKHDLEYRPQVGWLSKNKAAHTLLTFMMSSLDLFSDKLESTPTQLFETVFESGAASLGISDICLEPDLFNVDLGYDHHFELASIGKGESPREDTISDSDALHCTRSHDDMSERYFEAFVNYSTHLDPDSVDAAPTSLDNEGRFVSESPINHCNTSAPEPETEEDPLQFRTSQPHDKTVAKALSIVRTDESETLTQPESHSDHDSLFPSPLRPRAVSGTGIFSLHISESESAQAYSPMTSEDPSDTHDRRPTYFLLAFFLAYIFLGIAFLLFACIAPLAISLPGFFTATLVWVLAAVRTLTAMVTCGQQSMSTGSSLYSTLSVLLPSPNTGVVQEGTLTVLKLVTSSVPTPVPGHGQGQESIRAWFPWTPFEKDFVPVPASASGPAAEESITESHSPSPRERDDPPTSTPSISGPPVSSPSRPSSSSSSTSPSRIESVTKSNHTAGKALHKSPSVASSSSSSTTSTPRRTTTTTASCCRERALQRQHDGHRRDKTPSTRLNHVRAFHGPQYLDFAPSVRRFIDIVSFDLAVMMMKREETSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0W5</accession>
    <name>A0A0D2A0W5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238828.1">
        <property type="nucleotide sequence ID" value="XM_016377258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0W5"/>
    <dbReference type="STRING" id="91928.A0A0D2A0W5"/>
    <dbReference type="GeneID" id="27329984"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02901"/>
    <dbReference type="HOGENOM" id="CLU_042812_0_0_1"/>
    <dbReference type="OrthoDB" id="4161694at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238158" evidence="2">
        <location>
            <begin position="21"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="496" mass="48904" checksum="D6D70B888D4EF4A6" modified="2015-04-29" version="1">MHLRAITLLVASLTLAQAQARPDGMLYRRQYGNDTTSSDITTTIATPAAIDAALSTSSVATTTTADTGVGLTSSTTSTTTTTSLSTSTSAVAATTTADLASYTTTAAADDAVVTATTTTTSSSIDTANDVVASTTTTTTTTATATTNTTTTTTTATPTTAVAADNTTSIDVATSSSTSSSTTTSVRGKKKKTTSSLATSTTATAVVTSNSTTSTSSTDEVEGISTSSSGTTTSTSTAEMENVSSPSTSSSVTAEVTTPPAEGAVVAAKTTDSANIPADMTQTSSEAVEVSTTVEDKTFTMTIGSGPSASVVTTTIRQTKTFYVTSVVYATITKPSPTGANVGAGGVGASQNQAVGVTPTAGDGTTTITMVSTTTETVTVVPATTGVAADAGGACGVSYVTVTETIQSTVTVTAEPTLSKPSVANQAQETSPSASISASTSASTSASTTTTTSSSTSTTGAPYTFGNGTESHNLNLASSGFMTVSRFARETATGFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A2A5</accession>
    <name>A0A0D2A2A5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239263.1">
        <property type="nucleotide sequence ID" value="XM_016377693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A2A5"/>
    <dbReference type="STRING" id="91928.A0A0D2A2A5"/>
    <dbReference type="GeneID" id="27330420"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03337"/>
    <dbReference type="HOGENOM" id="CLU_002512_0_1_1"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056625">
        <property type="entry name" value="SH3_CYT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056624">
        <property type="entry name" value="WH_CYT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23214">
        <property type="entry name" value="SH3_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23216">
        <property type="entry name" value="WHD_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="570"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1084" mass="121873" checksum="108AD274805E070F" modified="2015-04-29" version="1">MWTNTSHVRSSIPRRLPYICQECRSQLLCRLTASARWRSYNIAHTRTEVCTSKNKRRQYHVHTSRRSPGQPGQSAPASTVYDHELLLDVARPGPPHAQSPKSVVRDHLRTWAIQNKKQKAEDAEVQYAQGQRLDTLPNSLFIEETTSDEDTLDQGLDEFDESVEAAETTSLIEPGDLVYIYSKHTGARGQWAIYLDAVLQNQHRLFLADGRWVAEPAVDTRCAPVCKSFASEEELRYIKKHLPVKHLDMRTDGIDEIPVVRSFAGDIPHDDGAALMQRVATLVDSVLDFRRSNIDILDSLYERIAHPEAYRTLTYVEIYAELFNTSSDNVPFEAEMAIYLQTKKTSTLMRAYSAGSTTARVSIIPRKAAASFDQVCAWAREYQEAAAEAALGKNVSSLLARNPLTKFIEKARGLILQSRDLRSPTTIGSLGPSSIKPATGRNVEAKESGVVFSEDDIKVLEFLWDCYARCPRPLHRNKNHSIGSLILRAIGAYPKLRLERKIGSLLLQELGVMAPWFETTDQHTAMPLAKRRGAEEIDTAFAESESMCEELGLSQNASHALLHDSLGHLREDLGAMSVFIVDSANTVVKDDGYSLEPHPDLPNTYWIHVHIAHPSAFFDPDHIFAKRARAVTRSYYTPTTVQQMLPGPLTESMSLDAGKPTTTISTLITESGEVLDIHVRPTRIHNTITMTHDEERALLGKPKSTRISYMVVGQPPRLNMLGPKYPTDDELQHLASHQPTLQKLEELAIARIKARRREVSEYIDLEILRPSLRTTIDYVEDYDPGRLFKSYHYVGDPAITVAHPHDLEISRTTDNEHIWPLTAMLMQLACESAGKWFGDRDIPAYFAGSSPQPGVSLSMLKNTGVFDLDRRLPRYINSASPIPHVYLDVASYVQCTSPLRRYTDLCVWWQADAYLRAVANGIIEPGESASKIELPFKRSDIEASFSDMARFQRAEVTLARVPMYTWAVRALFRAFHFKEVKLPEVWDVVVVNRETPSTGVREDDTGIRGWLHPFRIPMWLLKSPEGWEKSVRPGSFMPVKLELVDLSAGIVYCKPVGAPSGTPYHSEPLRIAPDGLSLPEENSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8U3</accession>
    <name>A0A0D2A8U3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241418.1">
        <property type="nucleotide sequence ID" value="XM_016376142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8U3"/>
    <dbReference type="STRING" id="91928.A0A0D2A8U3"/>
    <dbReference type="GeneID" id="27328865"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01782"/>
    <dbReference type="HOGENOM" id="CLU_117348_0_0_1"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="143" mass="16877" checksum="E508403445754051" modified="2015-04-29" version="1">MGSVVIPHLPSAWHVDQAILSEDERLVVIRFGRDWDPDCMRQDETLFKIAERVKNFAVIYVCDIDQVPDFNQMYELYDPVTLMFFFRNKHMMCDFGTGNNNKLNWVLEDKQELIDILETIYKGAKKGRGLVVSPKDYSTRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASW2</accession>
    <name>A0A0D2ASW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230034.1">
        <property type="nucleotide sequence ID" value="XM_016386226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASW2"/>
    <dbReference type="STRING" id="91928.A0A0D2ASW2"/>
    <dbReference type="GeneID" id="27339002"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11919"/>
    <dbReference type="HOGENOM" id="CLU_000288_125_15_1"/>
    <dbReference type="OrthoDB" id="4121059at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW09818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="283" mass="31967" checksum="795846B518609EB2" modified="2015-04-29" version="1">MYDSLTWAKPAALGTNKGIAAKLRAVQGRFLRLVASAADETISMHPLVQESVRYWLQHQGEKEASVEHAVKVLAASFPTGEYSNWPVCQNLFPHAQATLRHQGTGVIMRESRGRLQYHVSWFLWLSWQYTGALQHVSKSYHIRAALYGDENTEFLDILELMAAVLQSRGNYEDTETMHRQALAGREKELGENHPDTLTSVNNLAVVLQDQGKYEEAEEMYRRALTGYEEELGVDHPDTFSSVHNLAYLLHARQYFQQAMDLYQCAVAGFNRVLGPDHPTTAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUT7</accession>
    <name>A0A0D2AUT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230491.1">
        <property type="nucleotide sequence ID" value="XM_016385547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUT7"/>
    <dbReference type="STRING" id="91928.A0A0D2AUT7"/>
    <dbReference type="GeneID" id="27338320"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11237"/>
    <dbReference type="HOGENOM" id="CLU_014758_0_0_1"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="644" mass="74376" checksum="EB22AB389BDB8F68" modified="2015-04-29" version="1">MFGGNVWGAIAPASEALLDKERSPPPKPTPLEFPGYVPPRSDNPLDRSHLRSLCKDLASVRRPWDVKDSQLAQFNIQLDQNVSLSDMVPDGKFKSRPFLYDSELESMLKELEVENEDAYREIIRLPPLSGRQKPRLAYSRGFFTSLEDMCRYWDDSKDEYYEVEAADQESPNAETFKTPLAAKETDTPNAEKPKTKAPSEGNKAATAGTSSETALAESNTLPNIDVVGIPHRPKMKQVYRGLRIGNGQQMSPGTRVAAVRNLLKMAIHKFQCRDYDINPREKFRIRNINLPSTFLHFCVAKMPSDPKLARARIVEGPLMGVHSRIEVRFRPRDGSTDPANDSVGEKYDLFREVSGLLMLAKQRAREGQTQSKEPNQDHWWATRHRWGGGPTRWGQLACEVFEDDDPSWSPEERLLQLDKRTKVEEERKRTDVLATATDLNNLKPEDLISANASSENERPKKKKKGDDDSKDKAEYKDGRRLMFTAPIRRKWYQEWTRVRPNSPTWDEKFIYRRIGMADPEQGWDDVYMLSAANHHVCMVKLSVHENYLQWLETGETKRQASKSERQDQVLYMTRSRWFDLLDIEQRKELLTGIWRVLSWLNRDEVPEAELEKMIALRRQQQHHQQREEEEPQAFGNDGDHPMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUX0</accession>
    <name>A0A0D2AUX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_11462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230714.1">
        <property type="nucleotide sequence ID" value="XM_016385770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUX0"/>
    <dbReference type="STRING" id="91928.A0A0D2AUX0"/>
    <dbReference type="GeneID" id="27338545"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11462"/>
    <dbReference type="HOGENOM" id="CLU_007426_5_0_1"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="266"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW10498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="636" mass="70600" checksum="C5C28946D82946C0" modified="2015-04-29" version="1">MGQAARDRVKQLEEQVVMLKGALNDAKKTMRKNAPVTNLSPTTSVYQGISDTEAFGEPDEALPAAAGHIEWSSSSVTYVGNAHWRALLESIPGLEHMIGDGLQTSKNARQATKPQMPGPLSGIVPLVDRAEILAALPPRDTVDILLQEAFVNTDNERMIVHVPTFRKEYLQFWNDPDSTSIIWIGALFSLMCLSIQYQQFSSDEARRLQVATSDPQQLITTFHMRSTQCLLLGNYLEGPPYTVETLLLHLLADYLSGDHTEPSSATYALWGLIVRIALKSGYHRDGSHFPGMSAFQAETRRRVWLMILQWDIYLTSQQGLPRTVVRSQYDTAEPHNLEDEDFDSNTVELPPERPLSARTTARYHADKTRLLSVSNSINELCNALRPAPLNEVLKLDDLLTETYESVAPLWGMNGNNPSSQKGYLHGSFCNVKGMFLGVVYSRSQIALHHRYLVAGRTMPQYARSRKTCIEAALTMLQHQWRLYLETQVGGPLCRNGWKFLSLLVPDFLFATAFLCTELAQDLSEDGALPPTANDPLDTKARVFYSLSSAYIVWLQSRNYDSSRAVQTVVAVMKALLTMAQEAGFGGLGANGGPSFASSRSLLQPQCSTAPAPVSPDTEHSRPETPVTYHSITHFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVS7</accession>
    <name>A0A0D2AVS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230721.1">
        <property type="nucleotide sequence ID" value="XM_016385777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVS7"/>
    <dbReference type="STRING" id="91928.A0A0D2AVS7"/>
    <dbReference type="GeneID" id="27338552"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11469"/>
    <dbReference type="HOGENOM" id="CLU_028036_1_0_1"/>
    <dbReference type="OrthoDB" id="4113541at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025496">
        <property type="entry name" value="DUF4387"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14330">
        <property type="entry name" value="DUF4387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="36"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4387" evidence="2">
        <location>
            <begin position="511"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="614" mass="66978" checksum="8BF819118C64DA37" modified="2015-04-29" version="1">MSPGKIRDELRIFTPVGQFGQGWNAGIFWDTVESGVDAIIADAGSTDSGPGRLALGKTAASPAGYKRDLGELVKACHTHGVRCLIGSAGGSGSSELVDMNTRIIREIVEENGYRPMKVISIYAEIPKDVVRQKFKDGLISPCGQGVPALKEDDIDSAVRIVAQMGLEPYVKAMNENPDFDIIIGGRSYDPAPYAAFCIHHGFNDLGINYAMGKIMECGAQCAVPKTREGLAIVRHDSFDLIPLQPGARCTPTSVAAHLLYEKSRPDILQGPGGELHTRDMTYEQIDERTVRVRGPKFVPQTAGEYTVKLEAARVNGYQASFVGAFRDPILISQLDTWIPAVKETVKGRMSGNYEYETKIITYGINGVMGALEPNKTLPHEVCVVVQCKAPTMEQAMEVANRTKMGLTHAPYPGQLATAGNFAWPITPCETPIGPVPEFCIYHLIHKADPVGLFPFKVEEYKGSNTYVHTPREKVALQADAAVAIIKAPGKTTGQPKKYYLLPQPAEGTCYLGDVASVLRSKIAGPYEVTFDIMFPDDDTYNKVKASNLLSGPTVAKLYNIPESDIIAALWWDPARAFKATIPRYRASAGFEETDTHGSQQHAPLLYLTLPWGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AX40</accession>
    <name>A0A0D2AX40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231494.1">
        <property type="nucleotide sequence ID" value="XM_016384892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AX40"/>
    <dbReference type="GeneID" id="27337661"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10578"/>
    <dbReference type="HOGENOM" id="CLU_019366_3_0_1"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052121">
        <property type="entry name" value="F-box_SCF_Substrate_Recog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550:SF1">
        <property type="entry name" value="F-BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="570" mass="63215" checksum="F69F038D5565D499" modified="2015-04-29" version="1">MCSLLDLAPEVLHHIFTHVHPTDLSPLSMTCRYFNQVIQNDELLWKHHYLCLFDLPPEDGTTSWKTRTTQLVTAIKILEADDESTAALQEVLEATLKLIEVSVSQSPKNTDFLANHFKKAANLSAFLCKSSLFPRAAPGKWTAAPTAALRQLSARLHVLGGMNLEDPWPRIDGHTCIHIAASHDSSAEDDADDDDSSDSEDDNTNANTGTDNNNNENDTNNNNNNNNEDDYNDIDDIDDDDANDDDGTDGGEYPEVVSPAAASAGGDASTPSTSTSTTFSPQPIRYAHPYARSQVYDLRRYTQANKWGPFMDDGSGRIDWEKVQAIMIVIGFNYRMYAERRGASSSSHSGVLRPWDEAFFGIATNSYVSSPLSGKLRPSLHPDLDAVDPYGVTGTWMRIVCFLDFNDLYAFNFESGRLDPTQDREPLTTREAFRLIRLQLHVTAVDAPNPDLGDGDMPVVHFQGTSRSTFMAWDPNANSRIRGTVRKTASGAIRWTTFSIFHGEERWRSEGVQIGGIRSARGILGNWFDKDYDIHGPAGPTAFWKISDEMVEEAHHNPPPMVQIFLNGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AX62</accession>
    <name>A0A0D2AX62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231519.1">
        <property type="nucleotide sequence ID" value="XM_016384917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AX62"/>
    <dbReference type="GeneID" id="27337686"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10603"/>
    <dbReference type="HOGENOM" id="CLU_963230_0_0_1"/>
    <dbReference type="OrthoDB" id="3560543at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="289" mass="33285" checksum="5CE83D271D3A9254" modified="2015-04-29" version="1">MASRYCKALAEHGRPDNKRSDIVETYLQQIEDVQLGRRKFSAEYLESRELLEYWDLVQAMYREFFNDHPSYTEVGGGKLNELEIFEKDVEQLTTTLLAAVNSGSLNHDGRVTIRRRWSILDRLMQEHYSRTNTKRTSLSWSDIASQFREARSPNESKELNVDWTSTCMWLTFTATVIVALPTFALAFQYSPHARGSTLDADFWFLLQSCSMQFLGFLTVGIPMWKGKLLSVHVWYWTWGFIGLAMSCTLAAPFIYCKLRTEWSAFLVIVAGTIQAFVTLQITLIANHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXR0</accession>
    <name>A0A0D2AXR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_10540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231456.1">
        <property type="nucleotide sequence ID" value="XM_016384854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXR0"/>
    <dbReference type="GeneID" id="27337623"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10540"/>
    <dbReference type="HOGENOM" id="CLU_011220_0_1_1"/>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="191"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="470" mass="52586" checksum="C2250A33B500F101" modified="2015-04-29" version="1">MRPTSVRPTLALGSQYVCSSCRRPGYDAVRQPGFRPLHASPIFQRPRRREFFSSNPSLLSQSAQLRDEPKEDSANIQAQKRKTARSAGTKTSLRRIGLEAQRSKAGNLARSSGKSQEDIGTPKLVTAYAVADTFDLTKVVDILRSKGYEPDPLGTGLFPQVVHVQIPISSIYRSTNPAAVDLSSTEVGDAFIFPSGTLVTWALPEGFTSYFATRTLLPAAENPHKEPIETEDLDYIEDPTRKDSLIRGETIILGTKQNNSGSADMTSDLSREYQYQSVDTVLTKIAFSSGFARSTKLAVLETNLSTYLTSTADIPALLSKGSRLPFKLSRGFILRKTGQLLLLRAQLNLYSELTDSLPDIFWDSRHELNLENYYDQVGRALDVGIRIKVLNEKMDYAAEIATVLRERLSEKHGLFLEWMIIVLIAVEVGFEVLRLWKEGFWEEVWEESRGRSRASKKHESDRILEEAADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1C8</accession>
    <name>A0A0D2B1C8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232671.1">
        <property type="nucleotide sequence ID" value="XM_016384048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1C8"/>
    <dbReference type="STRING" id="91928.A0A0D2B1C8"/>
    <dbReference type="GeneID" id="27336815"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09732"/>
    <dbReference type="HOGENOM" id="CLU_019845_6_2_1"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF25">
        <property type="entry name" value="NAD(P)H DEHYDROGENASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249361" description="FAD/NAD(P)-binding domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="5"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="382" mass="40838" checksum="237D45C6154B479C" modified="2015-04-29" version="1">MSTHQIVIIGASFAGLTAAQGLLKTVIPSLGGKDKYKVVQIAPSEDFYWKIGAPRVIANPKSLPLEKALLPIAPYFNSYGPEQYEFVKAYVTSIDTATKTVHTSTSAAIHYDSLIIASGTNFNTPLWTVTDGPEALKAALDEVHRKIPEAKTILIAGGGAAGVETAGEFGETYGKTKEITILSGTTGLLPRLQNKKIGADAQSRLEKFGVKVVNDNVKVVEHTKEDGKDVLKLSNGETKTVDIYIDATGDKPNSKFVPQEWLNDRNQVKVDPHTLRLDVPGVTGVYGFGPVASYSDGAAIDISFAKGAFLETLRSDLSGATPGPRTKKIYKKMTSDMQIVPIGSQGGVGVLFGYKAPSFLVKMAKAKDYMIGRAVQTLDGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B676</accession>
    <name>A0A0D2B676_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234416.1">
        <property type="nucleotide sequence ID" value="XM_016381314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B676"/>
    <dbReference type="GeneID" id="27334064"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06981"/>
    <dbReference type="HOGENOM" id="CLU_744008_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="271"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="372" mass="40611" checksum="9F618855FB485250" modified="2015-04-29" version="1">MEQSNVQHHNAGQNSLDSKSREDFPATQNPIAARHSYILPLYPQQSRDTFISMSQPPVAPIDRNTSLQATYPGHDQFYGTPALAAQAQGLPYYPIHAHPSNRVGHPGHTYGAHEFSPTQVGLLNHGISPLPSVTGQQFCNPSVSGQGHHPSSLLQAHPPNQFFQPVQVGPADQANNAVQSSSPPNATRQPSQDGLTHLVGPEAMACAPAQLSSPHHVQPPMQIDHVNASIPGGLRRAPPLGNQASDQGQILKDCAEQIEELAQREATERQQKRLNHAGTERKYREKINNLINALFHALLGTGRASKLKVFHYDTDKKGTTKGWSRSKKCDVFHDAIAYIRQAESDIADLMAENESLRARLSAYEIVRQPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6D8</accession>
    <name>A0A0D2B6D8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_07216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234649.1">
        <property type="nucleotide sequence ID" value="XM_016381547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6D8"/>
    <dbReference type="STRING" id="91928.A0A0D2B6D8"/>
    <dbReference type="GeneID" id="27334299"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07216"/>
    <dbReference type="HOGENOM" id="CLU_005922_0_0_1"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000125">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF23">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="424"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="747"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW14433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1107" mass="124537" checksum="794193C20EFF57DE" modified="2015-04-29" version="1">MAAYASSPSFGSQTTAASASSIPSTRASWSDTRDTTPGSASERVFAHIKDIIYDATTSIEPDDSLGHYLTEVETSLATARSSVDFRRPDVAYKNYLRAYEIAVQRIPRHRDYGFWDNNPSWSSKYKATLRKINDLSDQMAQVREAIEDNNRRYGTQQRSVLRKPVYSTDFGVPSTMSPGAGRPSSSGKPNGPDARQTDSPRPAELPDALRIDRARPSNKPPKPESLQGRPLSEQSNDLSQRFARLRGPGSSQEAGHILSMPNPSDFQPGAGTAPRPQSYSPYATPKANGVSSHRINGPRDMPGIGSVPSIPPKVPLTTNMVMPKPPSPTYSPITTTPIAPHVNGGRLPTEGGRPPNERKQTYYNQSQNSSTTSLHIQRTRDEILSPYRPTTPNGINSAIFLKSSSSEIPHRPSIDAPTLLEYMKKYNVLLVDIRERVLFDDGHIMSSSIICIEPISLKEGVSAEELEDRLVLAPDMEQTHFSRRNEFDIVVYYDQDTSDISYLKGPPSMTRAPALRALYDTLYEFNDTKPLKDGRPPALLAGGLDAWIDLMGAQSLARSKTAAMLGTIQRRRAVGPGRPIARQRLVSANSRYEVRNRRLRDHKFLDESEQEAWRQQAMQEEVAPAEKSELASDEEYPTGDEEPPAESPFVPDYETFLRRFPSIKQQESMIMPARRALPSHPTAYLHQPVAPVPQVPTRPPPAIPRPSYSGQADINAPQPSLARVTSASRPPLYSSATSVRGKRLPKTGLTNFGVTCYMNSTLQCLSATIPLSAFFNDRMYEAYVQRNWKGSNGIMPKLYANLIQAVWQGDNEVIKPSTFRNFCGRMNREWVIDRQQDAKEFFDFIVDCLHEDLNVNWERTPLRPLTTAEEMQRERMEIARASPIEWKRYEHRDHSFLSSLFAGQHASRLRCLTCKRTSTTYEAFYSISIEIPRSGAGHIYDCLNSYCREEKLSELWRCPYCKGEREATKQIILTRLPQFLVIHFKRFAASKHEKAKKIHTPIEFPLYGLSMDDFVIPRPPSVPDAEGQVDMATTPPYSYDAYGVLRHLGNSGDGGHYISIVKDQGRGCWRKFDDERHIDLDPNKLSPRDRLQNSEAYIVFYQRAQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6U8</accession>
    <name>A0A0D2B6U8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234844.1">
        <property type="nucleotide sequence ID" value="XM_016381742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6U8"/>
    <dbReference type="STRING" id="91928.A0A0D2B6U8"/>
    <dbReference type="GeneID" id="27334495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07412"/>
    <dbReference type="HOGENOM" id="CLU_030125_1_0_1"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF0">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="4"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="417" mass="46496" checksum="B6E946D153CB1AC3" modified="2015-04-29" version="1">MPTALVTGATGITGRAITNKLLSSPEWTSITTLSRSQSSHSSNPKIHHATLDLQSSAESMASSLSGISAEYIFFCAYLARDDEAEAAKVNGAMLQNFIDALRHTGSIKSLKRLILVNGLKQYGVHLGRTKQPMHESDPRLRGDPWPENFYYTQQDILARAAREDLKSVGWTWVVTFPQDVIGVAKGNFMNLATAIGLYASVMATLPRGELAFPGSKENYLAFNCWTSAKTHAEFCAWAALEPKAGDEAFNVINGDTESWQNLWPKMAGRYGAKVPANMFPGEKYDGFEATRQELPTPMPLAVYAEAIGLKDEFEGKHSVIHQQIDTTKWAQRPDVVEAWEKLRDRFGLQQDTWDKATWTFVTFLFGRNYSCVASMSKARKLGWTGYQDTWDAFEETFEELEKEGILPKPKAGELRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7C1</accession>
    <name>A0A0D2B7C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234761.1">
        <property type="nucleotide sequence ID" value="XM_016381659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7C1"/>
    <dbReference type="STRING" id="91928.A0A0D2B7C1"/>
    <dbReference type="GeneID" id="27334412"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07329"/>
    <dbReference type="HOGENOM" id="CLU_007426_4_1_1"/>
    <dbReference type="OrthoDB" id="5431381at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="686"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="704"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="772"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="954" mass="105297" checksum="E5458FEE55D7408E" modified="2015-04-29" version="1">MATEFSALTGKFRANLEFSTSGGINKRNRQPLSCAPCRSKKLKCNRGHPCETCIRKGDVESCTYGKAGLVPSKPDFSSTSGANGANNNRGKAQERLRHLEQLVMQIVDKGGRPSQPRPNQSTIRSDATATVSTNASIAREGQFHIETADESRYMGSTHWSAILQNIQELKSALHVSPGSEETHVSVSSSGGGEGGSSQPDDGVEDTTTFDRDPPELEEEEGEEEETLFAAPSGTTLSHIISTCLPRREQVDRRLSTYFNSTYMVIPFIHTWEFQRQYEAFWAADPVDTSPFWLSILFSICCMSATLSEAMGLEPRTPDGQRSARATFLSASRQCLRLGGLTRLKRFSIEAFALYTQCVYIQTLDPSGETALIWAVLVRQAYRAGYHRDSSHFASSFSVFDGEMRRRVWAMLRQFDLMLSFQLGLPNQIPPGSWDTQDPRNLLDADFNVSTTELPPSRPENEATQILYFIVKSRLMTSFGKVTAHALSFRDASQADVMALDREVRAVHATVPDILRIRPMSQSFADPAYLVMVRLNCEFLFQKSLCVLHRKYMTVTDPVTGEDRYPESIAACVDAAVAIARRMLDMHKEFKPGGQLHDARWMLSSFTMNDFYLASIVLCLAVSIWKKRHPGGNIETDDADPRMRDVWVLLRSAFNITVELSPTSREAKRVADVLRVVLDGVGPATNRSNYLDSTLDQNQSRREQPSVSAGSDPATTQKVSGDRCRFLSTDHSRKEPVVGEWPRLHHHQQGRQGRQQDVFVDVHEFNLTPLSLNESVSRQQRQHQQGTKSADDWQLDCNPVTHGFPFQLPFQTPTVSGRTASQGNGSGTGMSGAGGYAAMGTTGDSGGGGVSSSASNGTDTFMTTATAMSTTTDTNADSSADMDTNANADTNPYMNTATTTATATASMNPMNVTLDMDMDIDWAFLDQWMAIGGGAGGDQQQQQQQDWMNSDFRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B845</accession>
    <name>A0A0D2B845_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_07640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235071.1">
        <property type="nucleotide sequence ID" value="XM_016381969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B845"/>
    <dbReference type="STRING" id="91928.A0A0D2B845"/>
    <dbReference type="GeneID" id="27334723"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07640"/>
    <dbReference type="HOGENOM" id="CLU_069491_1_0_1"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20446">
        <property type="entry name" value="Tudor_SpSPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="104"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW14855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="292" mass="31786" checksum="55E369E7CE6E3774" modified="2015-04-29" version="1">MSSAELAAFENELKEYSLQLETVQSSLQDDPDNTELQSLKSELEEVISLTEAAIAELKPASVPAHSAKPSPPPVKEKWSKENHPAYQAGYRKPDVEEEPHTPTTFAVNDNVMARWKSGDGGYYAARITSITGSSSDPVYIVTFKSYGNTETLKSRDIKPLSNEAKKRKADGISGSSTPVPAPPNPSVISAAASVDPTLAQQAKREPSKVSDGPVRPAKIPRKVKANKELEAGKTKWQDFAAKSKAGKFTKKESMFRTGQGVNARVGFTGSGHEMRKDPTRTRHIYQQGNSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8U7</accession>
    <name>A0A0D2B8U7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235291.1">
        <property type="nucleotide sequence ID" value="XM_016382189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8U7"/>
    <dbReference type="STRING" id="91928.A0A0D2B8U7"/>
    <dbReference type="GeneID" id="27334945"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07862"/>
    <dbReference type="HOGENOM" id="CLU_009455_0_0_1"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="187"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="780" mass="89446" checksum="F6F2AC12D02C4A53" modified="2015-04-29" version="1">MSVVTMLQPASRASTSTNSSFEPVTRQNTFSSHDGARSLRQSKRVSMTALYASMSAKDKDLEISDDLARAQRTLRDLKAKISSQSKKNFVLEKDVRYLDSRIALLIQNRMALEEQNEVASHLDDAVDLQEGSFPNDEKTQRYGNLFFMLQSEPKHIAHLCRLVTMAEIDSLLQTVMFTIFGNQYESREEHLLLTMFQSVLTHQFETTPEYSSLLRQNTPVSRMMTTYTRRGPGQSFLKEVLAEKINSLTELNDVDLEINPLKVYEAMVKQIEEDTGVLPDDLPRSVTAEFAAENVQVQAIITPRLKMLTDIAEGFLSAIIDCLEDTPYGIRWICKQIRNLSRRKYPDAQDQAICTLIGGFFFLRFINPAIVTPKSYMLIERVPEDKPKRTLTYIAKMLQNLANKPSYAKEPYMAKLQPFIQRNKDRCNKFMLDLCEVQDFYESLEMDNYVALSKRDLELNISLNEVYATHALLEKHSTELAKDPSSHLGVLLQELGQAPPQVPRKENRTVTLPLYSRWETSFDDFTHSLDITQEEIFFMEAKSTFVQIIRSIPQATAVIRRPLRLDRVAEAAGTLKNDAIMVRKGIRCMELLTQLSELGVIDRADDYAVLRDEVEQELAHLGSLKEKCLEETAKLDDVYKTIREHNAYLLSQLETYKNYLHNVRSQSEGTRRGKTEKVKELGPYKFSHAQLEKDGVIASSNVPENRRGNIFFMFRSPLAGTFVISLHYKGRARGLLELDLKLDDLLEMQKDGQEELDLEYVQFDVSKVLTLLNKRFARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8Y2</accession>
    <name>A0A0D2B8Y2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235331.1">
        <property type="nucleotide sequence ID" value="XM_016382229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8Y2"/>
    <dbReference type="STRING" id="91928.A0A0D2B8Y2"/>
    <dbReference type="GeneID" id="27334985"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07902"/>
    <dbReference type="HOGENOM" id="CLU_019313_1_0_1"/>
    <dbReference type="OrthoDB" id="4116575at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="584" mass="66263" checksum="65C6C6D21B3954DE" modified="2015-04-29" version="1">MHASTKSWNGCWTCRVRHKKCDETFPQCQTCSSLLITCYYTEEKPEWMDNGERQQDMVNRLKLEVKEKASMRRAMGYIREAEERQNNDSRGSQYLLPHRGPNNNARITSQQQSQAPAETPPKPQPRKVWPGCDAGFMSYYLDFFFPFLFPFYRPHMLEGGRSWLLEFLNEAEGMQQSAMAFSSYLFTIVLDASEAGHEFCININWDKMLAEMSNTFTGLKNEVALLGETSMDSPAELSRAVRILGVITHLQRFEIATSGFANCKMHLDAAVQAFKTILGADVANSHLDVGSRFFQIMAHLGPSPWPKPYLSYQITSPEQVAFRFFASLLVADDIIASTSLGEEPRLYHYHAQLMADEPENQSAVDLEVITGCQNGVMQQIGEISFLAAWKRRQRRQDDAMALELARRGASIKDRLEGRLELLERATEPVSRVPSGITRLFAGWQQEPTFPAMQSRHITQIWAHAALIYDLVTINGSLDPTNPDICAHIVKIMQIIDQKLTPPELLRMVAWPFCVAGCLAKPEQQSWFRRKGRDLEPPGLFVTVRKALEIMESTWVRMEAQEYSSLGNTNMASCFAATGEIIFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9C4</accession>
    <name>A0A0D2B9C4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235476.1">
        <property type="nucleotide sequence ID" value="XM_016379649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9C4"/>
    <dbReference type="STRING" id="91928.A0A0D2B9C4"/>
    <dbReference type="GeneID" id="27332388"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05305"/>
    <dbReference type="HOGENOM" id="CLU_027499_0_0_1"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="489" mass="54992" checksum="AD27ABF42289F982" modified="2015-04-29" version="1">MDDLDLPPIPQSAIIAAQTPPRPRQSLLLARKRTRAEVYDDEPTLTTSSDPALFSSDEQAPGAENYTDRRRKKRTFKGSWWDRHPAREGLRKSARQKREFTRNFDSGIFMGSQDESGEDHDLLSSDSFTLEDELMRDQSREHERGHHMTRQQRPFRLWAQESSPDQRHRAEGRVRTTTDSISPKTKILPKVKPLEPMSEAHREVCEIVHQCLDMGKEDVDLSGRSLDSLPEEITSLQTLAKQDEIVPGMLDTGTDLEPQLRVYLANNLFTTFPAPILELKNLRLLSLRNNCLTSIPPGIRDLVNLTTLNIAGNQLNELPWEIVGLARSHKLTRLIAAGNPWRQQRPLTLGQENTSDGLSNMLSQPVGERGRKSAAPSGGVPSLSETVLRQLARLDPKQKIDFRGLMPNGTSDMVLDKLDLLKTQPNRQCGYCGRLMVMAASENLEWVALWPGSPVLPFRRLECADGCEKNSRSGPEGKSDSTMEPIEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BA20</accession>
    <name>A0A0D2BA20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">PV08_05893</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236059.1">
        <property type="nucleotide sequence ID" value="XM_016380232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BA20"/>
    <dbReference type="STRING" id="91928.A0A0D2BA20"/>
    <dbReference type="GeneID" id="27332976"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05893"/>
    <dbReference type="HOGENOM" id="CLU_036502_1_0_1"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="338"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="505"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW15843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="634" mass="68862" checksum="862720402E48C7A5" modified="2015-04-29" version="1">MAFNFNWSPLSTDAGFLPRAQELLTNALNRADPKPAIIVDDIVVNELNLGDVPPELEILEIGDLAEDRFRGTFKMMYKGNAYLTLKTKVQANPLNTYLRTRSAFASPQPLAADTGLTIPLQITLSEFRLTGFIILVFSRQKGLTLVFRNDPLESLRVSSTFDSIPFVANFLQKEIETQLRGLLMDELPAIIHRLSLRLWVPEQQAQEERELGTLQPTKDEVVVDPLASPPQDPVDSTGAVLTPAEIASLSLDSSVETQSLFSRKNLIRLATLTDSHRTLSLFTPSIRDAVFRAWTGPLERGEMSPSHPHTRSPTPALSRSHSYAGSLSTATTYTFDSTHTRPTLQTMNSASHGLGMGGGRHGQGHRRRRKKRVVDLRAHPETGEPESVTESGSSNIDTESVSESTSATAPSVFSAPAATTSFDSPRGLGIITPPTSPVVARKPGLPQSLHHRSNNSGTRSVSEGIPGLSVAAQIDERRLGVEATPKSSDPNATIRVRNNRRIIPTIATTSNVDDDETPRASLYIPPPQKEGQVPPPLSFQQSTTASPAIPAGPSTEKSGLQEAGSGSGPSLTPLPNFLQFVADPSNAGSIAERAWMMKMAAELARRYEDERLKGSFGPMSPREEERLPPPAYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAA7</accession>
    <name>A0A0D2BAA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236139.1">
        <property type="nucleotide sequence ID" value="XM_016380312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAA7"/>
    <dbReference type="GeneID" id="27333056"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05973"/>
    <dbReference type="HOGENOM" id="CLU_026673_29_1_1"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="56"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="351" mass="37778" checksum="4F4B33528E0C0EDC" modified="2015-04-29" version="1">MVSNKAFMYKAVPDGWPVAGKDLAIEEITFDESAPPPKGGFTTKNLYATYDPSQRGRMRDPSIKSYSPPMTPGKPVVAVQVIGKVLKSDNPKFPEGSIAILWAHPTESYSAVDETAAGKAEVITPRPGVPLTANLGPLGMTGMTAYGSLLEIGQPKKGDVILVSAAAGAVGQVVGQIAVRMGLHVIGSVGDDKKLDFIINQLGFTSGFNYKKENMADAVKRLAPDGLDIYYDNVGGELLDIAMTNMKDFGRIVACGTISTYNNGSTSTPYGLKNYSSVVRKRLRYQGFLVFDPNIARWRAERDENISKWIADGSFKSIDHITTGMDNAIDGFLGMLEGKNLGKSILKIADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE72</accession>
    <name>A0A0D2BE72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AttH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237111.1">
        <property type="nucleotide sequence ID" value="XM_016378434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE72"/>
    <dbReference type="STRING" id="91928.A0A0D2BE72"/>
    <dbReference type="GeneID" id="27331168"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04085"/>
    <dbReference type="HOGENOM" id="CLU_051719_1_0_1"/>
    <dbReference type="OrthoDB" id="5344254at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057722">
        <property type="entry name" value="AsqO/PenF-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056402">
        <property type="entry name" value="DA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25581">
        <property type="entry name" value="AsqO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24137">
        <property type="entry name" value="DA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239055" description="AttH domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase N-terminal" evidence="2">
        <location>
            <begin position="57"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="AsqO/PenF-like C-terminal" evidence="3">
        <location>
            <begin position="240"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="39065" checksum="E975742B7B387981" modified="2015-04-29" version="1">MRSLFFRVASAILALAGMTTAQCPAESMTFSPILYAGASQVQFTSCASGADSPRVFPINATTFDWWYFDAVSDDGEQALTVIFFTSSALGFSFDLLNTVDPLNVYVFANTGSGNQPVSFPVAATSVTVDTVGNGASGNWVGSGIKFEGASDLSTYTVTFEHTLLNTGISGTFTLTTRGPGHYVCGPLEGGQPEEVLPHVGWVNVMPAASASVDVTILGTQMQFSGNGYHDKNWGDVPFITALNSWYWGHGTFGDYNVVFFDMIDPSNNEKVGGYVLKDGQVVGSTCTTGLQVRPVDAPYPPTLTGANPTQLTITMTLNDGSILNATVTELATQIDVGLYTRWIGTIEGTVNGVTSSGTALWEQFKTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFV1</accession>
    <name>A0A0D2BFV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_04664</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237686.1">
        <property type="nucleotide sequence ID" value="XM_016379009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFV1"/>
    <dbReference type="STRING" id="91928.A0A0D2BFV1"/>
    <dbReference type="GeneID" id="27331747"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04664"/>
    <dbReference type="HOGENOM" id="CLU_016848_2_1_1"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="89"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="215"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW17470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="584" mass="65742" checksum="E732D2EC191D2C13" modified="2015-04-29" version="1">MSKRKSEEPLENLLVEASPSNKRPRAEDVPEGVPESTSTIRNGANHERKPLSTNGGTSAVREEADENPESDSDTEDDRLPNAPLRQAAPTEGYCDLYLDTINRTLLDFDFEKLCSITLSNINVYACLVCGKYFQGRGPKSHAYFHALEVDHHVYINMETKKVYVLPEGYEVHNKSLDDIKYVVDPKFTEDEVRKLDKDPRVSTDLSNKKYRPGFIGMNNIKANDYLNVVVQALAHVAPIRNFFLLHQFPQTTPQLPVRFSALVRKIWNSKAFRSHVSPHELLQEIALRSSKKFTLTQQSDPVEFLSWFLNTLHLSLGGSKTKLLSSIIQRTFQGKLRVESQAITAKSDTTGDRLRFEDSSTITTNTTPFMILTLDLPPVPLFRDAVESKNIIPQVPLTTLLQKYNGINASERQAHRVRHRLLHPLPQYLLFHVKRFSVNKFVSERNPTIVTFGSPKGLDMSPYVEPNPALHPPGEPILYELAANIILDTTSVSTGGGEDSNAADAANLAAGADGQRVAWKVQLHDKAVAYAKRNDLPEWMEIQDLYVERAEAETLFTREGYLMVWERKKEKPKANGNAPGKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BG59</accession>
    <name>A0A0D2BG59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237811.1">
        <property type="nucleotide sequence ID" value="XM_016379134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BG59"/>
    <dbReference type="GeneID" id="27331873"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04790"/>
    <dbReference type="HOGENOM" id="CLU_683409_0_0_1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="403" mass="45283" checksum="4DE8BDF071E337F8" modified="2015-04-29" version="1">MPVTSLQDSDKDPDKNWDNDRISFVSQLNKAEPPGLTIIVGEYSWKAHARKLCSCSEFFKRIMLSHEGAINVTLTLHEETPILVGSLLRWLYTLHYYEPKDNDATQTDPLVPNLRHIMAQGRGAPTWDLSPMLDRQILEEPDSFHAQMYWLADRYQIHKLKEEAIAKFKYQLLLFPDDLVLNLKHLLGCPNESMAESAARGPSLTPVTIATPSMPVPSGGTVAGPVEICQVFNPSNALNGINGDTGLHLKSTAQPEESTTMNTALILNPTPEQERAIRRRTITLEDDTGLWYFLVARTSELLSQHINDTTFSTIMQGNPSFQWAVLQQAAIRHTTNQFTIQELRDEVQVLSDRIRVLDEDRISLLSYTSDQPTYFPITPPPRGRELPPCTGAASTPKARRSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGP6</accession>
    <name>A0A0D2BGP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED11</name>
        <name evidence="6" type="ORF">PV08_02461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238389.1">
        <property type="nucleotide sequence ID" value="XM_016376819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGP6"/>
    <dbReference type="STRING" id="91928.A0A0D2BGP6"/>
    <dbReference type="GeneID" id="27329544"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02461"/>
    <dbReference type="HOGENOM" id="CLU_094325_0_1_1"/>
    <dbReference type="OrthoDB" id="5418434at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="180" mass="19259" checksum="644B6E6092C426D3" modified="2015-04-29" version="1">MDLDVPASAEASSFSPADRIAELNEIDRSISTLLSAASEAIGILSNQPTSEAQATALQNPEAARAAFTTAADTYFSTLSSIEVRLRRQVYALEEANLILPGDERDSRRGRAFGGDSSLTKVGGGPLDPSWLNARASDKVGAGMKRELISRAREFVERADRGLQDPVTNNDTTQDADKEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGS7</accession>
    <name>A0A0D2BGS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238051.1">
        <property type="nucleotide sequence ID" value="XM_016379374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGS7"/>
    <dbReference type="STRING" id="91928.A0A0D2BGS7"/>
    <dbReference type="GeneID" id="27332113"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05030"/>
    <dbReference type="HOGENOM" id="CLU_045003_0_0_1"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112396" description="Peptide hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="121"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="385" mass="43710" checksum="88E1F57EBF4D51C1" modified="2015-04-29" version="1">MWRCSTRWLLTLVLSFLRVVAYTPLSDDTILNRLPLPDIADFDTRTGNILAPILIPRVPGTPGSAQVLQHFVDFFRTSLPDWTVTFQNSTSKTPTHGAKEVPFVNLIATRDPPWSRPGDVGRLTLVAHYDSKYKPDGFIGATDSAAPCAMLLHAVRAIDAALTKKWDSVQAQEDLDLDFAENKGIQVLLLDGEEAFQSWTATDSIYGARSLAEEWENTMHPATSIYKNYLDSIELFVLLDLLGSPEDLPIPSWQHSSHWSYVKMAEAEERLRDLGMFKSRSRRNWLLDKDKKETEMFNSYMMQDDHIPFIARGVQVLHLIPARFPSVWHTINDDADHLDIDVVKDWALLTTAFAAEYMELEGFFEAPPSRKVKRTNETVISKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHJ6</accession>
    <name>A0A0D2BHJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein END3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein end3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_02362</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238291.1">
        <property type="nucleotide sequence ID" value="XM_016376721.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BHJ6"/>
    <dbReference type="GeneID" id="27329445"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02362"/>
    <dbReference type="HOGENOM" id="CLU_002006_0_0_1"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="16">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="16">
        <location>
            <begin position="161"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="16">
        <location>
            <begin position="309"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="342"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="15">
        <location>
            <begin position="1382"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="100"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="380"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="487"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="703"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="526"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="704"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="806"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
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        <location>
            <begin position="929"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="961"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="977"/>
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    </feature>
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        <location>
            <begin position="1044"/>
            <end position="1055"/>
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    </feature>
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        <location>
            <begin position="1065"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1082"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1106"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1126"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1186"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1200"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1235"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1330"/>
            <end position="1366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW18075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1429" mass="151130" checksum="5CE0938D16F08E57" modified="2015-04-29" version="1">MLLRSRCVDKYSLGHPNLNLSAEEKRVYGQLLKDADPDGFGAVSGDVAVKFFERTKLPPDVLGQIWQIADTENRGFLTPAGFGVALRLIGHAQAGRVPSAQLAPQPAPLPRFDNAAGEQPQPAPPQPQPQPQSIPQQLTGTPTSPAAAAHPIRVPALGPDKVAEYSSLFEKSGAENGFLSGVVAKQIFERARLPNDVLGRIWALSDTQGRGSLDVTEFVIAMHLLTSYKSGQMRGVPSALPPGLYEAASRRTPVRMGSGSRPGSSALHGVPPQLPAFNARPQSPITRQQVSTPLSAQSTGEAWAITPADKARFDTIFASIDRQGSGYIDGEQAVEFFGNARLPEEVLAQIWDLADINSEGRLNKDEFAVAMYLIRQQRATRDGRGNLPPTLPPALVPPSMRKQQAPPPQPTAPSFENAPVTKPRSAADDLFGLDAFGPTPSVPTPAIPQVAQSTGGTDAGPFANPPSFAASLSPQHTSTTFKPFIPSSSFGQSIIPQSTGSPAPQAKSPPMPSDDLLGDADPEISSKLTSETSELGNLSNQVSTLSKQMTEVQGTRKQTEQEISTTSAQKRAFEGRLAQLRSLYEKEVQEVKALQEQLTVNKTEIKRLQQDMAMIDGTHQDLSTQHQQLRTQLESDQRENLALKERIRQTNQEVDQLKPQLDKLKSEARQTKGLVAINKKQLATNETERDRIKAEIAAAQQELEDAKREAEESARQVEASKREVEDAQREAEESARQVEASKKELEEARSVPTPSVKSPPPVASPAPSTNSNPFFRRTTETSFSPPISEEQPKDHSQNAFDSIFGPSFASAASPAPAVSFSSSSPPAGSTSAQPSETGESTPYRAPGEAPPPPESRQLTSASLPFRRPLEREDSISSSVKVAVPTSRLSPSDTPRALTPTTSTSSPSGAPQSHDDPFTTSAPDEEQESVRQTLPQPSSGDTAEDAFGKPSLGSFGIPGAFPSNSRSATPAEGTSSRTATAGAEIPAAATAAIAASVSSEDTAARDGTTGPALPSTERNFDDYFGGPVHQRTASQKAADFDSAFASIQQPQATNGAGDSAGKEFPDIQELDGDDDSSDYSDETPMKFDDDFTAKSPPKDTSNGGDIKAGKQREFEPGADAHRPSLPQAASTASSLPPPDAQTSPPTYGDVVPHDDPAHFPPEFKGLLPERQDPTLSPPTEGGSSNPGPLPSGEPPAYGPEAHARSPKESKASAPPPTVAAPFDFDSAFTGVGAAPVEDDNDEDEDAGSFTASKTAADFDPTFDSPPQARSSAAPHPTTYGAGTTNGAHQGGGENFSFSNGSPGGPGTGPNVASSHDWDALFAPLNTNTAFPATEPAGQEAAPPAVQPAEATSASATPASASLAAPASKPQRPQPGRALSTGTEHDDPILKRLTAMGWSREESLAALEQFDYNIDKVRSPWLVQPHRCDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHT5</accession>
    <name>A0A0D2BHT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238411.1">
        <property type="nucleotide sequence ID" value="XM_016376841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHT5"/>
    <dbReference type="GeneID" id="27329566"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02483"/>
    <dbReference type="HOGENOM" id="CLU_093936_1_2_1"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF2">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="5">
        <location>
            <begin position="10"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="216" mass="23942" checksum="83FFBDE08C414552" modified="2015-04-29" version="1">MANSDTHTAFFYGTLMAPGVLHRVIDGTHSPSESQASRLTIRPALLHSYTRHRVRNADYPAILPSPDVSTACVRGSLVTGLTSADLYRLDIFEGDQYVRRKVRVQVLKDVGLDEVAPTDSAHVLEEVEAETYVWDEGEATLEPKEWDFEEFKRDKMKAWMGMAQSEEVEVDGGFADVDRAVAEQEKALQGEGQNHDPMGGRGANGHITRQLEEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BI47</accession>
    <name>A0A0D2BI47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_02922</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238849.1">
        <property type="nucleotide sequence ID" value="XM_016377279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BI47"/>
    <dbReference type="STRING" id="91928.A0A0D2BI47"/>
    <dbReference type="GeneID" id="27330005"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02922"/>
    <dbReference type="HOGENOM" id="CLU_007727_0_3_1"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="36"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="430"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="508"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="546"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="639"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW18633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="678" mass="74494" checksum="E087C9710FD9F19E" modified="2015-04-29" version="1">MSFAPVDPPKLKGDSKKRVAYFYDSDVGNYAYVSGHPMKPHRIRLAHSLVMNYGLYKHMEIYRAKPATKYEMTQFHTDEYIDFLAKVTPDNMDSYAKEQQKYNVGDDCPVFDGLFEFCGISAGGSMEGAARLNRQKADIAINWAGGLHHAKKSEASGFCYVNDIVLGIIELLRFHKRVLYIDIDVHHGDGVEEAFYTTDRVMTASFHKYGEYFPGTGELRDIGVGLGKHYAVNFPLRDGIDDSSYKSIFEPVIRAIMEFYQPEAVVLQCGGDSLSGDRLGCFNLSMKGHANCVNFVKSFNLPTLIVGGGGYTMRNVARTWAFETGCIVGEPMHPNLPYNDYYEYYAPDYELDVRPSNMDNANSREYLEKILVQVLDNLKRTAHAPSVQMTDVPRESLGMNDDDEAALDDLDEDQTGDIRMSQRRADKYVEKNGELSDSDEEVVEDSNGRHTNRKRRIMQNYRHIMDVGNDSGLDTGSGVDTPQQDSSLPGDEMNVDENLNDEIREILGEGPVPANGSVVASKSPSPPAVDTADGDIEMGEADAEPATTNSTQPADEESTITVQPQTAHQSTPPESPPVQQPDHNAVNGDKAASATTKREGSAEETSAAEPLAASSDQPDATGGPIEETAVKQEVVGDDDVAKAQDEGRLEREAANAEGEARTEAAARAEMDAEPEAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIB9</accession>
    <name>A0A0D2BIB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238571.1">
        <property type="nucleotide sequence ID" value="XM_016377001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIB9"/>
    <dbReference type="STRING" id="91928.A0A0D2BIB9"/>
    <dbReference type="GeneID" id="27329726"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02643"/>
    <dbReference type="HOGENOM" id="CLU_030273_1_1_1"/>
    <dbReference type="OrthoDB" id="17395at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050032">
        <property type="term" value="F:L-rhamnonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03327">
        <property type="entry name" value="MR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000005">
        <property type="entry name" value="Putative L-rhamnonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023444">
        <property type="entry name" value="L-Rhamnon_dehydrat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011968">
        <property type="entry name" value="PRK15440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00006">
        <property type="entry name" value="rhamnonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="171"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="434" mass="48360" checksum="53898D76C4383C04" modified="2015-04-29" version="1">MPTGVKAFPTIKGVRTFVIEGVGSGGDYHNVEGGHWLIDNKISTPMSKWERYRKSRTSFGINVLGSFCVEIEATDGTTGFATGFGGPPACWLVQQHFERFLVGRDPRDVNDLYELMYKGSMFYGRKGLPVAVISVLDLALWDLLGKIRNEPVYKMIGGSTRDRLHFYCTGPEPAAAQQMGFSGAKVPLPYSPEEPDSLKKNIAFLKKHREDIGPDFPLRVDCWMSLNVQYTIELVSEAKRQDIRIDWWEEVLSPDDFDGFQLLKRAHPDTKFTTGEHEYSRYGFRKLLEGRNVDIIQPDVMWLGGLTELLKVSSMAAAYDVPVVPHASGPYSYHFVVSQHNSPFQEYLANSPDGKSVLPVFGDLFLNEPIPTQGYLDVSVLDKPGFGLELNPNARLVDATELLGMKPQRSLPPPSEEPEAERNGEGSVNGVSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK54</accession>
    <name>A0A0D2BK54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231870.1">
        <property type="nucleotide sequence ID" value="XM_016385268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK54"/>
    <dbReference type="STRING" id="91928.A0A0D2BK54"/>
    <dbReference type="GeneID" id="27338039"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10956"/>
    <dbReference type="HOGENOM" id="CLU_035914_0_0_1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254572" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="410" mass="44622" checksum="6F953EDBD343935B" modified="2015-04-29" version="1">MQLKHLVPAFLALYGAQAAPSSSPAEQLNAFAERDTAAASANSIYIPASTLQTDILAAKALVNLAIYQVTNPPKGSCNILNAAVRREWSTLSKQERLAYINAELCLMSKPSKDPSFAAGAKTRYDDFVAVHINQTLTIHGTANFLSWHRYFTWSFEQALRNECGYTGYQPYWNWGKYAFDPLNSPLFDGSDYSMSGNGAYAPHGCTEAITSDLNCIPPGSGGGCVTTGPFKNYVVNLGPVSPTLDVPGIINYSNPNPLAYNPRCLRRDISSWVSSNWTKDSDVYDLVTGYTDILSFQNRMQGDFPTGFYGVHTAGHFTTGGDPGGDLFASPGEPTFFLHHAQIDRTWWIWQNQDLKNRQNALAGGTSLLDPTGSPAGKLTDPIYLGSLASTVEIQDVMSTTGGPLCYIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL05</accession>
    <name>A0A0D2BL05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239854.1">
        <property type="nucleotide sequence ID" value="XM_016374578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL05"/>
    <dbReference type="STRING" id="91928.A0A0D2BL05"/>
    <dbReference type="GeneID" id="27327295"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00212"/>
    <dbReference type="HOGENOM" id="CLU_066898_2_0_1"/>
    <dbReference type="OrthoDB" id="3503208at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39502" checksum="180A579C67AC9064" modified="2015-04-29" version="1">MEQLLLRYVGTERHKRKVGTAGWEVVDELVDIPAIQAQRNPPSSKTAIRNPLVSSLQGRNRYGCYKGTQIPLNPGICHNVTKLSSLKTDHELRTSQIVTYEEYLPLRLALLEKEKQATRARDGLSAERRQLPLVEVATPYKFTAVDAAGDHKEVTLLDLFNGRPQLIVYHFMFDPDWDAGCSSCSLFADHIPPLEHLNSHSTSFAAVSRAPIEKIEGYKKRMGWTFPWVSSNGTSFNYDFHVTQDESVAPVQYNFKDKAQLEQRGQAFFARGEQPGHSVFVLGGDQSGIGEPGKAYHSYSAYARGGEHLIGTLGWLDMTPLGRLDGINGVPGLGYKRHDEYTDDDLKGIVAKIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLU5</accession>
    <name>A0A0D2BLU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232370.1">
        <property type="nucleotide sequence ID" value="XM_016383747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLU5"/>
    <dbReference type="STRING" id="91928.A0A0D2BLU5"/>
    <dbReference type="GeneID" id="27336512"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09429"/>
    <dbReference type="HOGENOM" id="CLU_021599_5_2_1"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42269" checksum="AA934DC8BCC00871" modified="2015-04-29" version="1">MPGCLPRECLECFATSYYGRRQGSDRIQRSGTKLYSQCLRKLNSCLRAPGSSMASETVMSIIILTICEYLVATSPTAWIEHMHGLAAYFRFKGLEIFRQPLILELFESTRFQMITAAVASRQATFLASDSWETEPWRIAGVAKNAVQFLIDLAAKIPALYVDFIQYLKTADPIMKEQMSVALEVNMAILFEKFQQWHHEWEKENDPVIQRVALSSEEQQYYGVSSKLAFVSIDHMFTEVHYLQSLIILLELWKTFRGAAVKLTPDAQDDQSCASEEIETARSAPLPSTTSLHMESHTAAQEICRIIINCLQPSGRLAYVVQFILAMRMALIVLRQEEGNLQVTWLEDCLQRSSEITHGWDIGKIAMQSYQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLW6</accession>
    <name>A0A0D2BLW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239776.1">
        <property type="nucleotide sequence ID" value="XM_016374500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLW6"/>
    <dbReference type="STRING" id="91928.A0A0D2BLW6"/>
    <dbReference type="GeneID" id="27327216"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00133"/>
    <dbReference type="HOGENOM" id="CLU_023205_7_0_1"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19164">
        <property type="entry name" value="AKR_ARA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000037">
        <property type="entry name" value="L-galactose dehydrogenase (L-GalDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044480">
        <property type="entry name" value="Ara2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="435" mass="47856" checksum="98E7DA06476A0B5B" modified="2015-04-29" version="1">MPRPQSPLSESLPPLIFGTATFNYQYNLDPYALGPTPLVQKALALGVRAFDTSPYYGPAEEILGAALDTDLVRKHYPRESYFILTKVGRIASDVFDYSPEWVRKSIQRSCKRLKTAYLDAVYCHDCEFVSPQEVLGAVRELRRIRDEEGTLKYVGISGYPVHVLCELAEMILRETGEPLDIVQSYANFTLQNTRLLTEGLQRLVNAGVDVVPNASPLGMGLLRRNGTPLGAMGNWHPAPDGLRQACIDAAKWADAQGEKLEVVAVRFALENWLREGAKAGALGNPLGSSEATYGHILDLPSEKLGVSVMGVSKVEELDETMRVWRSVLDGLADDPDAEPGTITPSDAVTDHEWSLWRRQNIRVLAKGIRTVIGQQWVDFTWPSPDPGFVNSLRMADAHVSQPPAPYENSPEVLMPTPPSEAADDGSDIPKMSCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMP9</accession>
    <name>A0A0D2BMP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GET1</name>
        <name evidence="12" type="ORF">PV08_00425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240066.1">
        <property type="nucleotide sequence ID" value="XM_016374790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMP9"/>
    <dbReference type="STRING" id="91928.A0A0D2BMP9"/>
    <dbReference type="GeneID" id="27327508"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00425"/>
    <dbReference type="HOGENOM" id="CLU_089418_1_0_1"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000006">
        <property type="entry name" value="Protein GET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239112" evidence="11">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW19850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="205" mass="23607" checksum="3C16A010FFB9BBB8" modified="2015-04-29" version="1">MLSLLVVVFLIQLVCHLVLTIGSKPINDLLWQIYCRLPLQSSRDMKEQLRLRREVVRLKREMNAVSAQDEFPKWAKIRRQHDKAMEEHDKKAAAVSSLKASFDTKATAIRWLCTSGLRFGLQFWHAKTPIFTYPRGWFPWYAEFLLGFPRCPYGGVSINVWSTACATVIALVWDVVIYVIQYIQETRTGLKAKRPVPVPAGEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN10</accession>
    <name>A0A0D2BN10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="12" type="ORF">PV08_00515</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240156.1">
        <property type="nucleotide sequence ID" value="XM_016374880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN10"/>
    <dbReference type="STRING" id="91928.A0A0D2BN10"/>
    <dbReference type="GeneID" id="27327598"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00515"/>
    <dbReference type="HOGENOM" id="CLU_022610_2_2_1"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="168"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="297"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="325"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW19940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="491" mass="55415" checksum="528BF638442E1AA6" modified="2015-04-29" version="1">MASLLRWLLPRFTSNFTIPGTPRKLKMNSADLPELFQPPVNRSMQTLDRSFFRKSVPLAAATVLDLKEITNVRKQLERSGDILRLSPIRPLRDDDQVPGAKCFLLSPHVDANAPETWSPILSQLVDNKSAMLRPFTLTLTYDDWTMHNILEAILPDVPEDEKETPAGFAQVGHVAHVNLRTPYLPYKHLIGQVLLDKNPNVTTVINKTFDVGTESVFRTFPYEVLAGPDDLDVVVHEAGCEFRFNFGKVYWNSRLGTEHARIFESFKEGEAVCDVMAGVGPFAVPAGKGKVFVRANDLNPDCYTSLSDAIKRNKVDEFVMASCDDGRKFIRKATMELAQTPRKVILKPKVKVSRKASVEERKAAEEAASKSARTLEEPTSFDHYVMNLPATAIEFLDAFKGVYHNRQTEFAPHTTRKLPFIHLYLFQAKLATEEEECREICERISQYIGTEVKSTDPELEMSVRYVRLVAPKKKMYCASFRIPAATAFAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQT0</accession>
    <name>A0A0D2BQT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caleosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241574.1">
        <property type="nucleotide sequence ID" value="XM_016376298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQT0"/>
    <dbReference type="STRING" id="91928.A0A0D2BQT0"/>
    <dbReference type="GeneID" id="27329021"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01938"/>
    <dbReference type="HOGENOM" id="CLU_062049_1_0_1"/>
    <dbReference type="OrthoDB" id="640742at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007736">
        <property type="entry name" value="Caleosin-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495:SF0">
        <property type="entry name" value="BINDING PROTEIN CALEOSIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495">
        <property type="entry name" value="PEROXYGENASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05042">
        <property type="entry name" value="Caleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28534" checksum="705A7C940141807B" modified="2015-04-29" version="1">MAIPPAASATDQHPTVRKRSTATTSDLNGEASRLSDGHEEPAQLTALQHHVLFWDRDNDGIIHPKDVYDGFRALGFNVLFSLGSLLIPIFFSYPTGLGHSWFPDPWLRIYVGSIHKAKHGSDTGIFDLDGHFHRDRFDEMFSRWDEDGCGGLSADQMWRMWKKNRCAADVAGWCFSFMELWTTWLLLQKNGRVWKDDLLACYDGSLFWKISEANADANKKKPWSQGYGVQDFFDGWLRGRTWRNWELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQW7</accession>
    <name>A0A0D2BQW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241614.1">
        <property type="nucleotide sequence ID" value="XM_016376338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQW7"/>
    <dbReference type="STRING" id="91928.A0A0D2BQW7"/>
    <dbReference type="GeneID" id="27329061"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01978"/>
    <dbReference type="HOGENOM" id="CLU_811425_0_0_1"/>
    <dbReference type="OrthoDB" id="4161764at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="55"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="342" mass="38100" checksum="781B153F3F1CC39B" modified="2015-04-29" version="1">MSSYSFQRSVLSSASNESPEEVRKEASPLSPMPFLVSRLYAPHYECVHFSPGAFRRQGTVLGQGATFSVEKHAVEEIGIGMLQNMELREQYAAKWPVVAIKRLRCNSHIPTRSFETIEKELILLMALRGHEHVVQMIGIGWETAPISGDYRLWPVLVTEFAESGSLAHLQSQDSKLPYLTKRRLCLHVAAGVKSLHQLHLIHGDLKSENVLVFGSTPNQFVAKLADFGYVPMDYSLTNAASGLSSHGKSTAAARLGTDQWNPPEPLDLGSKNHLEARDVYAWGLLVLRVMLDGRNPFGIPTTWERSAHGYQRRFSLLAGLEEELGDVEDDQKSETNSVQPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR68</accession>
    <name>A0A0D2BR68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241146.1">
        <property type="nucleotide sequence ID" value="XM_016375870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR68"/>
    <dbReference type="GeneID" id="27328592"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01509"/>
    <dbReference type="HOGENOM" id="CLU_028750_0_0_1"/>
    <dbReference type="OrthoDB" id="10659248at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="489" mass="50098" checksum="6A82DE1489411FDF" modified="2015-04-29" version="1">MAVNVTETAGVGSTRLLSFSSTAFDSSCHFLSGSSCLGPNAPLTSGEAPPWGNTSLVTSSSSASHSGRVFTVLTIDFTPPPESVVATVFVPESSEAASETSSSLNNATVSSSLSIMTIVTIAVGSNTGAVQTASLTRVSFSPTSSREVGPLNGSTILTVSPPTSSSTSADFNSSSTSSSWNSTLSSEVSGALTTGPSATGAGPSSNSSSNEAMTSSSAFWSNSTTASVSSLTTASGWLDWNMTAGILTALSQYNISFQATATSENGSVSLASPTITSSSWNISVTTTFPSTTNSTGLSPESNFTTSPTSTLRTTKSTLATESPAITASSNNSTTSWSSAAGSTSLSPNASTICDTNATVAFCASSNAPWLASETAAPTITTNSTNGTGWSMTSMEATTFTTSFVSASGSGSGDSGVNSTSATWHPLVQPHRAEGRPRRRWVKREEQRRRENNGPQGDDADGHHDGDPGQRKREGTSWVRAQMERMFLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSD0</accession>
    <name>A0A0D2BSD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234350.1">
        <property type="nucleotide sequence ID" value="XM_016381248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSD0"/>
    <dbReference type="STRING" id="91928.A0A0D2BSD0"/>
    <dbReference type="GeneID" id="27333998"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06915"/>
    <dbReference type="HOGENOM" id="CLU_019940_4_1_1"/>
    <dbReference type="OrthoDB" id="4392727at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="47651" checksum="F6010C5D146897A3" modified="2015-04-29" version="1">MDDRALLYFMVLFIFKYLRLIIQGVSYLRYQPIRIPENPNLAPTDVTVVIATLGKELKALSEGLQCHVRAGIQHISICTPPDTFDLVTTLSNGIIKRHDDIHIHVSQTPFANKREQLATAIARVPRVRKEAHKIIVFADDDIAFPENTFRWMLAAFERDKVGGVGTSQRVRRLAAGSVSERVINWIFADYIARRNFENLATLTIDGSISCLSGRLAGFRSDIVEDPKFLKGFVSETWNGQKLNADDDNYWTRHLLEKGWDINVQCHPECQVETVFRTSLPELWRFVRWQRSNPRSNWRSLRNFRNWRRYSWGTYSLYLSGFVNYGLPPDIMLWRLWLRIAPPDEKQWRWVAWFLIWWLFAKIAKRLPLFCENWRDVVFLPVAILWGWCHDFIKLYALMTVSQTGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BT23</accession>
    <name>A0A0D2BT23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_02130</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241766.1">
        <property type="nucleotide sequence ID" value="XM_016376490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BT23"/>
    <dbReference type="STRING" id="91928.A0A0D2BT23"/>
    <dbReference type="GeneID" id="27329213"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02130"/>
    <dbReference type="HOGENOM" id="CLU_001524_2_1_1"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08641">
        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000003">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000006">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
        <property type="entry name" value="POLG_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="696"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1066"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1135"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1158"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW21550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1171" mass="132190" checksum="29D0CE43215160B5" modified="2015-04-29" version="1">MLWPPAPAQCARGYIRTSQKFRLRQPYATRAAAILRRYYASDAVHRSPSSPLDQNNTLARPSRSRYNDIGVQQLSDYVHPQIFPAGATRPRADLVELSKDHLRRHELLGKNQDNAPSIGLDTPPIFGTTLDEHFTKLGMDASEPYLSYGKAFVRANTPERPRKWVIRSGWTKYNSDMTTEEVDAPDEMMLSFDVETMWKETPFAVMATAASPTAWYAWISPYLLGESDNPRQLIPLGDPSKPRIVVGHNIGYDRARVKEEYDLKQSKNFFIDTMSLHVAVNGMCSRQRPTWMKHKKNRDLRDKMAGDHNSLELQRMLENKTLSEEEEELWVGRSSINSLRDVAKFHCGVTIDKSQRDFFGELDREGIRERIDELLDYCAADVAITHKVFQKVFPNFLETCPHPVSFGALRHLSSVILPVDESWDRYLERAEGTYQQRLKDVEDRLIQLSEAALAVKDQPEVYTTDPWLNQLDWSGQEIKYKKTKKKGEAPVPVARQKKPGAPNWYRDLFTSNTSPLNLTVRTRIAPILLKLSWDGYPLIWSDKHGWTFRVPEKDVLKYELSNVVSCDMSEETNQTLKSDMKNVYFKLPHKDGPTARCVTPLAKGYQQYFEAGTLSSQFALAKEALEMNASCSYWISARDRITSQMVVREADRDPSLGGKTNQGFILPQIIPMGTITRRAVENTWLTASNAKANRVGSELKAMIKAPPGYCFVGADVDSQELWIASLVGDAQFQLHGGNAIGFMTLEGTKAAGTDLHSKTAKILGISRNDAKVFNYGRIYGAGLKFAAQLLRQFNPLLSEKETNEIASRLYKETKGTRTRRKAFGNGSFWRGGTESFVFNRLEEFAEQERPRTPILGAGITEALMRRFINQGSFMTSRINWAIQSSGVDYLHLLIISMDYLIRRFNLDARLAITVHDEIRYLVKHEDRYRAALALQISNLWTRAMFSQQMGIEDLPQSCAFFSAVDIDHVLRKEVDMDCVTPSHPEKIPHGESLDINQLLAKGSEAFLDPAVKPKTGPIDLDKYRYTPRASVMSTLNGTDGVDIAYIRAQITSDDKELKTIVKDAEKAEADSTSSANQSGHDEVKRTGSGTASAVPKTPAKAPRGRRPKPKVPIPPHAQPQRAMLMEVEDRWNLGYTKAFGNSGTGTTKAPWLADKKSSPWTYKSSQDGWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWM1</accession>
    <name>A0A0D2BWM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235900.1">
        <property type="nucleotide sequence ID" value="XM_016380073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWM1"/>
    <dbReference type="STRING" id="91928.A0A0D2BWM1"/>
    <dbReference type="GeneID" id="27332817"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05734"/>
    <dbReference type="HOGENOM" id="CLU_130502_0_1_1"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="108" mass="11491" checksum="580BABE8077B62DA" modified="2015-04-29" version="1">MAPKKAKKTSDSINSRLALVMKSGKVTLGYKSTLKCLRSGKAKLVIIAGNTPPLRKSELEYYSMLSKTNVHHFAGNNIELGTACGKLYRCSTMAVLDAGDSDILGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWS4</accession>
    <name>A0A0D2BWS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_05804</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235970.1">
        <property type="nucleotide sequence ID" value="XM_016380143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWS4"/>
    <dbReference type="STRING" id="91928.A0A0D2BWS4"/>
    <dbReference type="GeneID" id="27332887"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05804"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_8_1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001202">
        <property type="entry name" value="Translation elongation factor EF-1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="272"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="68"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW15754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="702" mass="76496" checksum="09148B875563CEAB" modified="2015-04-29" version="1">MSGNFDSWEDAAAQDEDLSRQTQNMNINANANTFRPGASSFQPGANSFQPGQQYQQNGYQNYGGYGQQQGYNQYPQYGQGYNTQYPQYQQQQQPQQGYNQGYSGQFTAYNQAPGSFQPRQGAPISIARRSDAQPAPAPQPAPQSQPAPAPAAEKAPTPKPAAAPPKAKVLSIGVPTAASASPKKPASPTAKEAPSKIEPKVDTKPEAGSKKIAAKAVEKTGEKVSGKTSPTPSSGKSSPTPGEPKKGRNAEEIAAEQTADVDASVLEEMYGKEHVNIIFIGHVDAGKSTLGGQVLIQTGMVDERTLDKYKRDAKDAGRETWYISWVLDLNKEERAKGKTVEVGRGFFETEKRRYTILDAPGHKTYVPNMLSGAAQADVAILVISARKGEFETGFEKGGQTQEHAMLIKTTGAKELVVAVNKMDDITVEWSKERYDEIVGKLKPYLKKRIGLDSTFMPISAQTGIGVKDRIPKDVAGWYKGPSLLEFLDGMAKIQRNLNAPFMMPVGAKYRDMGTMIEGRIEAGVIQKSANYVMMPNKEEVGIAALYGETEEEIPYAACGDQVRMRLRGIEEEDILPGFVLCSPKRLVHCVSEFEAQINIVELKSILSAGFNCVLHVHAATEEVTFAALLHKLEPKTGRKSKKPPAFAAKGQNIIARLQVTGSAGRICVERFEDYPQLGRFTLRDQGQTIAVGKITKLILDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXA4</accession>
    <name>A0A0D2BXA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236140.1">
        <property type="nucleotide sequence ID" value="XM_016380313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BXA4"/>
    <dbReference type="STRING" id="91928.A0A0D2BXA4"/>
    <dbReference type="GeneID" id="27333057"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05974"/>
    <dbReference type="HOGENOM" id="CLU_031811_0_1_1"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25542">
        <property type="entry name" value="zf-CCCH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="2">
        <location>
            <begin position="71"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Tandem CCCH zinc finger" evidence="4">
        <location>
            <begin position="422"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54173" checksum="A35FF32B040D916B" modified="2015-04-29" version="1">MAALPTHHDLLERLEDYRTFDESRQNEVAHLIQTCLRLNSETLVLQSDLDDERATRRGWKKRAEEAEAAIQRKFVVVLVDGDGYQFRKCFYDALSASGGSKAANELWMRVVDNLKAAPTSSGITSDCDVLVSVYANKIGLAKILVACEYINHISQIDQFFSSFTQSRSLFQFIDCGHGKERVDSKLRDTLRFYANNAQCQHIFLACSHDNGYIAELDKYRHDIVVMPKVILVHAAQTPSAVKAYSGLPFKHTRFDSVFEDTVLEAPARVEVPYFVPAPDPPSHDPRLPEQSNLDLTPTVSRSSYSSSNPTAPQGSTPLAPLPPNSKPSTQVSSPSSVSDMSKTKPNGTAVNGTGESKNGIPVNRFGQRIDLKIRPPTPADLDKFDNRISHRKLCNEHHLRDNCESYSCRYNHDPIDATMKNTLRYKARSIPCSSGAKCRRLNCFYGHQCPWGNNNCGNPKCAFIKAGLHDIKDLEIARCVAAQPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0S6</accession>
    <name>A0A0D2C0S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237500.1">
        <property type="nucleotide sequence ID" value="XM_016378823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0S6"/>
    <dbReference type="STRING" id="91928.A0A0D2C0S6"/>
    <dbReference type="GeneID" id="27331558"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04475"/>
    <dbReference type="HOGENOM" id="CLU_1282965_0_0_1"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21381" checksum="0569964C78D07D77" modified="2015-04-29" version="1">MAQTGKDNPHGPSIDAMLRGLTERPNVQSTLILSRKDGSIIRATGLDYPEKQTPSGADSSYRWRSSQQEPRSEASADGTNKPSAVEDTGSRPRPAEALAASVFQFVTSASFLGQTLGSTSRHVSGVEASLSAAGYSAAAQSPKSEVVDEESDIRDSEDEVQLLRLRIKHKEIIIFPDANYICCVVQRAGKAGNTSESRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3L9</accession>
    <name>A0A0D2C3L9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238455.1">
        <property type="nucleotide sequence ID" value="XM_016376885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3L9"/>
    <dbReference type="STRING" id="91928.A0A0D2C3L9"/>
    <dbReference type="GeneID" id="27329610"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02527"/>
    <dbReference type="HOGENOM" id="CLU_010194_13_1_1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF11">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="291" mass="31173" checksum="F73AFC6B73607EEB" modified="2015-04-29" version="1">MFAFFDIAEDEIHGLENKVIIITGGTSGIGFATAELFSSKGAVVIQADLNPPPRTLPGSHYIKTDVTSWTDLASLFRRVVDDHGKIDVAFANAGVSPKADYLQLASKDNGDLIEPTRLCLEINLVAVVNTVALALHYMQKQETGGSVIMTTSVAGYQPFGQADYTVSKHGVVGILRGIREHLYPKVPIRVNAVAPSWTATPIVSLPHAAFEKVGLGVQPPSKVALAVGLLVTDPTRHAQTIYSVNGRYKELEEEVMAATATAMGFHSVEMTEAGRFQDLVKEAEAGLSSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C535</accession>
    <name>A0A0D2C535_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238925.1">
        <property type="nucleotide sequence ID" value="XM_016377355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C535"/>
    <dbReference type="STRING" id="91928.A0A0D2C535"/>
    <dbReference type="GeneID" id="27330081"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02998"/>
    <dbReference type="HOGENOM" id="CLU_019574_0_0_1"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="815" mass="90516" checksum="F7368ACD4D41D951" modified="2015-04-29" version="1">MHQGMKEPQHINHRQKSQQYNPEKIAQLDQRFYRLQESVVPRQPYLLSVPSSVPYRHSSRFVNTWYEGTPFERHEEQLQYLSFFAHQGEHESLLKVEGGWADEQGHPIEDEVSPRTVPASGRNTPAEPGHRKKISLKDYKTKGKSPLTLQPRSQPLQSLKETEPPGASDAEGQNEVKPAQINAERVVIPQKTDIEQLDLRSKVAPLSIPGSSQSPARGQPENSPSPVKKRKLSPPFEASKPATHPPKGEATPSTMAMPTLLSPTLPPPEHETGLPQLLSPILPPTLAKALSNSPPFLGSPANGSHQRTDSVRSILAGVDLDNDPLPDKNKLAPTGGRVRSDSAHSARSSAPGTPSASKNLLGSKVLSKNGIRPGTPVLNGARASPGPRQRHTIILKYGKKNRKRVEALLKFQSRPKKESVKQERVGTPEIKPKREGIKQEEKDGGQTPDTKSTISVGDDVKVEKKRKAEESPGPAIKKLKSANLNAEDVKRPSTPVPTAGKSPLPSQTRTTFSTPKKDLKSSAMRRVESTDGVDVPTPSGDKGRVSTPVSSLKPSPQPNASSTREEERQQWSIVNNKYFAMGRSLKHEGTSMLSSSEANPKSIQVTKAVVLVVEALLCFIINTYARGRSRPGADPDWRSILPYHIFVYRQSRKYPHLHGLVMQLGAVCRQQIQKHDLDKLARDPLPDEYCSSAPTPSSDGNTKTNEDVEKYKKRYTQFRDDMIHNIRELQTAWLDGFRHLSPELLRREYPTTWSMRAKDATLRLQEKPSPSKLPKDFYLPMDANTTPLEAARFGLAFLTEWAGKEKIDWKTKIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C782</accession>
    <name>A0A0D2C782_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239635.1">
        <property type="nucleotide sequence ID" value="XM_016378065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C782"/>
    <dbReference type="STRING" id="91928.A0A0D2C782"/>
    <dbReference type="GeneID" id="27330797"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03714"/>
    <dbReference type="HOGENOM" id="CLU_006937_8_1_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="64459" checksum="F172F949D2C0F76A" modified="2015-04-29" version="1">MALPSQLDILVIGAGFGGLCALKHLRDEGYTIKVIDTASDVGGTWYWNRYPGAMSDSKSVIYRFSWDKDDLRNYPWSDHYLKQTEILQYFQHVATKHDLYKDIQFQTELTSAVYNGETGRWNVSLSTGETIDARYLVTALGVLSAPNYPKIPGLETFNGRIVHTSRWPADLDLSQTRVGVIGNGSTGVQVITGLAGHTKSLVSFQRHPQYSVPSGDGPVSSGYRQWVNDNYDAIFSRAKQSYVGMELFESNRPYDSVPPEEAEKIFEHLWQRGNGFSFYYGGFNDIGFNKVANEHACNFIRSKIDSIVQDPEKARKLKPNELHVRRPICDNGYYYAFNKPGVEIVHIGETPIVAVRKNGIETTAGFHELDVIVFATGFDAVDGNYNRIRIRGRAGKSLQEYWDARERGPSAYLGASVPEFPNLLMIGGPLGPFANYPPVVETYTELISGLLAEAERARRLPGSRPGSEGTIIEATKQAEDEWTIAAENVIDSSLFKEANSWLFGNNVEGKKRAIRFHFGGMGHFYNTVHRVINEGFAGFQPFLQNKSTTGHGADVKAIKTHVEDAEVNGISNTKVDIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8N4</accession>
    <name>A0A0D2C8N4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the VPS36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240120.1">
        <property type="nucleotide sequence ID" value="XM_016374844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C8N4"/>
    <dbReference type="STRING" id="91928.A0A0D2C8N4"/>
    <dbReference type="GeneID" id="27327562"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00479"/>
    <dbReference type="HOGENOM" id="CLU_015433_2_0_1"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000165">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000527">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031558">
        <property type="entry name" value="Vps36-NZF-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16988">
        <property type="entry name" value="Vps36-NZF-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="603" mass="65727" checksum="8A01D692424FD2C4" modified="2015-04-29" version="1">MFLKRPDLTAGSRPTLADDETLLMVQDGVGLYEGKYKIASCQKGHVYLTSHRAYYVDDADPRNNSWAIELKEVEKYEYQAGFLKSSAKVTLFPKPLKRGFGDSAAKPLQFQRLASASSPTSRSTSPFRSPAMSTTAEPLVVGTWVCPICSFSNPVPSNFDPTIATEAFPLPPCLACGIKPPFALVLKAAIAANAKRVPESRINTSHGAEAIASPTTHDDGNITDDVPCPRCTFRNHPGMRICELCSSPLPVPSSIQRVAFAESTNRSESPGPEIAGLTLEDEQHELLSVKFSFRTGGDRVFYDRLKNAMIQRKWLLQSAPPIPRAETRPMTPVDNASPASLPGPRTSAVGIAGLEQRGLETRRNNETVLGNAFGDLEALMASAKDIVALAEKFATETGSGLGLTGSLSDPLLSRSAAALGMVTTKDIVGDSSNTLYISELARNLAEYATDDRRGILRSQGGTMSLVDFWAMFNRSQNGVELVSPSDFHKAAEAWEKLGLPVKIRRFRSGLLAVQRRDASDEKTVKQLKDWLESLRVPEPEHIPAWDWSTFGFGVTAQQAAAKFGWSLGVAVEELEMAEEKGALCREEGVEGLKFWLNFLVQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8N9</accession>
    <name>A0A0D2C8N9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C45 hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240125.1">
        <property type="nucleotide sequence ID" value="XM_016374849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C8N9"/>
    <dbReference type="STRING" id="91928.A0A0D2C8N9"/>
    <dbReference type="GeneID" id="27327567"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00484"/>
    <dbReference type="HOGENOM" id="CLU_037787_1_0_1"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="106"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="340" mass="37357" checksum="1F0E33B671D79B3C" modified="2015-04-29" version="1">MKHVKCSGSPFEIGRQHGNSAKTEVHGSIAFYEAFFKERTKLSWPQVRDVARAFVPFLEMSYPDYLEEMKGVASGAAVDLESIIALNVRTEIAYGMLSDGCTAFAWKTSDESFIGQNWDWRIEQTPNIICLSIEQPPKPTIKMMTEGGLIGKIGLNSAGVGVTLNAIVALGVSYNKLPVHLALRRVLDSTSRQEAETALQQAGVAAASHITIADAATGACGLECSALDIVEMPMDPRGICTHSNHFVKEHKVQGSSFLPDSPFRLSRIQELLSGIEKPTMHNFTEMFKDEKNYPAAICRAVSEKSTIQTLFSIVMDLKQRTAKVKMGRPTEGGEVFELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C979</accession>
    <name>A0A0D2C979_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240340.1">
        <property type="nucleotide sequence ID" value="XM_016375064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C979"/>
    <dbReference type="STRING" id="91928.A0A0D2C979"/>
    <dbReference type="GeneID" id="27327782"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00699"/>
    <dbReference type="HOGENOM" id="CLU_009377_3_1_1"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="609"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="701" mass="78112" checksum="13366981CC434959" modified="2015-04-29" version="1">MADASQSDGDSNTFKIVPACDTCRARKIRCDRKTPCSSCQSSGASCHTSKRKPEKRQRVLISGRYEREIEKVNDRLARLETLLQAANSRQARLQPSPQSYAETLSTPRDKSGFEKEPDFAGDSSFVAHSKDATQAFERSLNLNVRGDVAAAVATLRTFLDNDGPSVAAGSDTALVQKPIQEAVLYPELAKLELPSMQVVLGVLRHAKTHPYQVFYEYPLLDVERLSDLCRKIYFPTDDYTIATFITVHVALYFLCNQMPKDTAKDLNFSSDELQQLADTCAHNAETAMRSMRLFMEASFETIEALLLAAMMTVEHSNLSLGWTLMTTASRMLQDAGYHRLPPYSVAPEATKKRIVFWLVYALERSLALCLGRSSNIQDCDITVERPKVPEELNGPFGLLYLGWIHLGELQGQIYEQLYCARAQKQSPEAKGHVARALAGRLFEMEAHFKIEIEGYPFAEAVSENLHSTRISLATLLTLIYRMIPPDPLPSGQPHHPLKFHDLAIKSAREAVIMHNDAWNVLRHRQRQEWYLFVVWTVQWSPFVPYIVVFGNAIADRNVEDLQLLKEVVDGLESIADMSPGAGKLYRSCQKFYQIASIYLAQVKADNNESQQGSSFDSSGSSARKVSQPAQAPAPAPAQTSISSLDASMSELPLFQQDWDEMLEGWQLRTDGGDTGDISAFFGQYLGGGAGNFAEPPTEPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CA07</accession>
    <name>A0A0D2CA07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240615.1">
        <property type="nucleotide sequence ID" value="XM_016375339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CA07"/>
    <dbReference type="STRING" id="91928.A0A0D2CA07"/>
    <dbReference type="GeneID" id="27328057"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00974"/>
    <dbReference type="HOGENOM" id="CLU_059021_3_4_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812">
        <property type="entry name" value="BLR2425 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="268" mass="29563" checksum="49DFFD7A49357F32" modified="2015-04-29" version="1">MFYEPGKTEHNLPHDPFKACVVPRPIGWISTVSPTNITTTTTTTTNNASSSSPSGTTPGTRPGPIANLAPYSQFNNLTFDPPYVMFSANQTPRSAQKDTVRNAEATGVFCWQLATYPLRDAVNKSAEYLPYGVDEFERAGLAKTWSRVLKTPVPMVRDSPVRFECEYYTTLRLPGNPPMGTVDVVIGKVVGIHIDEHVLTDGRIDINKTKPIARCGYYEYIMASDPFSMIIPGDPATLYGLEGSVKHHKEHREREAAEKSGVDQSSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAJ3</accession>
    <name>A0A0D2CAJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240805.1">
        <property type="nucleotide sequence ID" value="XM_016375529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CAJ3"/>
    <dbReference type="GeneID" id="27328247"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01164"/>
    <dbReference type="HOGENOM" id="CLU_162857_0_1_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="77" mass="8307" checksum="C35F824940050C3C" modified="2015-04-29" version="1">MSGKSGSNSFTPYTITNTGTNTQGNNWDTRTQPGGAAYHYSNTDGSYYYSNSDGSKYYNNGSGYSNYTPPSGNTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CC48</accession>
    <name>A0A0D2CC48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241250.1">
        <property type="nucleotide sequence ID" value="XM_016375974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CC48"/>
    <dbReference type="STRING" id="91928.A0A0D2CC48"/>
    <dbReference type="GeneID" id="27328696"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01613"/>
    <dbReference type="HOGENOM" id="CLU_122931_0_0_1"/>
    <dbReference type="OrthoDB" id="5419235at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="24912" checksum="151CC87266C906E1" modified="2015-04-29" version="1">MGAETPASPALDTSSAVAPETAARAEAGAEEADFVPGNLLSLSTTNFPDTFFMNPFAVSFPGDIPCYPEVSMTDSSTATTPSMTWSAIPKTAPPCPTQDASAVEATTCTRSLVNTPASLPTSSQNRPLAADAPRTSATPVYGSSLLLLSSSPSSSTTKVIKTTSNPPAVQGRQIHFVDMADKKGAQRIRNTMNSRKHRQNKLDKIRELEKKLAGLEEEKGKWRERAEGLGWKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y4K7</accession>
    <name>A0A0D1Y4K7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Schlafen group 3-like DNA/RNA helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230087.1">
        <property type="nucleotide sequence ID" value="XM_016386279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y4K7"/>
    <dbReference type="GeneID" id="27339055"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11972"/>
    <dbReference type="HOGENOM" id="CLU_874465_0_0_1"/>
    <dbReference type="OrthoDB" id="411123at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018647">
        <property type="entry name" value="SLFN_3-like_DNA/RNA_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09848">
        <property type="entry name" value="SLFN-g3_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Schlafen group 3-like DNA/RNA helicase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="318" mass="36333" checksum="CD5367C2BE652E71" modified="2015-04-29" version="1">MVLTPFEVAQADGQFDLLLVDETHRLNQRANQPSGVLNAKVRDITINLFGSDDTSKTQLDWIQAKSQHQIFLLDAAQSVRPADLPTEVLSMLAAEALESGRYFQLQTQMRVKAGSFFISYIRGILNPNRLLVPHVMPNFGDYDFRAFDNVEDMRDEIFRRDAEAGLSRLVAGYAWEWTKKDKNALDITIGQTRLKWNTTSTDWIASEKSLEEVGSIHTVQGYDLNYVGVIIGLDLRYSPEQQRLWVSRASYFDKKGKEQNRKLGRSYSDDDLLRFITQIYAVLLTRGIRGTYVYACDPDLRDYLKGFIPSSPHRHVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y5R1</accession>
    <name>A0A0D1Y5R1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear distribution protein RO10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230472.1">
        <property type="nucleotide sequence ID" value="XM_016385528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y5R1"/>
    <dbReference type="STRING" id="91928.A0A0D1Y5R1"/>
    <dbReference type="GeneID" id="27338301"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11218"/>
    <dbReference type="HOGENOM" id="CLU_091042_1_0_1"/>
    <dbReference type="OrthoDB" id="5403729at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24804" checksum="1D38868927FF8689" modified="2015-04-29" version="1">MAVDTKDPEAAARGTLALLETRLRHLEFLLKGTTNQDGIPEPATSPAQGKDTVWSRLDVLQASFERLKKHNGATSIMIRDVEHLSSAYPDLFASTETTTEVPKSQDLSTLASIVLAHATLFPETASRLSSLQTLQIPPAEHSSELLSLVPRLERCNQTEEELANEVRALRERSAHCLEWWIKVGVVGMGDLWEDWERRVGEVEKHLIRWERRAKEEQGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YB95</accession>
    <name>A0A0D1YB95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_09477</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232417.1">
        <property type="nucleotide sequence ID" value="XM_016383794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YB95"/>
    <dbReference type="STRING" id="91928.A0A0D1YB95"/>
    <dbReference type="GeneID" id="27336560"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09477"/>
    <dbReference type="HOGENOM" id="CLU_030898_1_0_1"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="531"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW12201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="565" mass="63163" checksum="5DCE7D8072A813CE" modified="2015-04-29" version="1">MFAETVALVCSGWYIFIACVCAIGYLNLFIHYRKVPVRAAVLAKDKTDIPHVTVIRPCKGLEPYLYECLASTFLQDYPPDKIDVYLCVSSRSDSAYPILERVVHDYPDRNARIFIEEEDDDAAGPDSSRAYLGPNPKIRNMSKAYREAKSDLIWIIDCNVWVGRGICARMVDRLCGFTQPGLPPATPYKLVHHLPISVDVDTYSKGRPRTDSSAYDETPTTPLLANTGGRRSSALTHLNRYGGRLEELFLSSSHAKMYVAINMVAVAPCIVGKSNMFRRSHLDHLTSVCARVEDAPGPAGGTTPVSARTGIDYFSSNICEDHLIGDLLWKSKLPRLPGFPSRMRNHGLVLGDLAIQPIAGMSVANYVARRVRWLRVRKFTVPVATLVEPGTESFLCSAYGAFGATTLPSTRPFFGTTWTWCALWWLVSITIWAAVDWTVYLLLHSGRTVDDADDGQKVPEFVRRSKTNSPARDLTRARRPFKEWLFAWLGREALALPIWTWAIWGGVSVTWRDRRFWVGLDMKVHEIHETSTATTSTETTTAMPLGMTNGHTNGNGHMNGKKRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCD8</accession>
    <name>A0A0D1YCD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_09838</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232777.1">
        <property type="nucleotide sequence ID" value="XM_016384154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCD8"/>
    <dbReference type="STRING" id="91928.A0A0D1YCD8"/>
    <dbReference type="MEROPS" id="M01.A25"/>
    <dbReference type="GeneID" id="27336921"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09838"/>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_1"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF171">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="259"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="545"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW12561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="880" mass="98326" checksum="0A96846E0432B3CF" modified="2015-04-29" version="1">MLLEQDTSKAPTLLAQSIKPSNYQLSIFDIEFGGQWSYQGKAVIDAEATVSTNKIIVHSENLEVLRAEVKCGLDYVLVQDASSILPSRDEKQVCLQFTELVTKGPFRLHVSFRGQIDPDMTGFYRSKYEPHGDLDAASVKVGSDCYMLATHFEPCDARRAFPCFDEPHLKATFELELEIPLDLTALSNMPEKSSRPLDGSKKGLKTVSFEKSPVMSTYLLAWAVGDFEYAEALTTRTYSSGRIPVRIYTTKGLTQYAQFALKDACDTLDLFSESFGVEYPLPKCDHLVVHDFISGAMENWGLITYKPTKILFDPVTADNRLMSKASYVVAHELAHQWFGNLVTMSGWNELWLNEGFATWAGYFAVDRLHPDWNIWGQFVDEAMEEAFALDSLDASHPVEVDIASESQARQMFDSISYCKGSSVIRMLASYLGKGPFLKGIAAYLESRLYGNATSDDLWRALSQESGVDVAGLMDSWIHRAGFPLINVVPALDSVELSQRPFIRKATIDKDSLWHIPIGLDAQKHTGDWKRLCTKSIMIKTPAVSKINHDHTGFYRTHYPSEYLLSILQMRQSLSSEDKVGILADMRALVFAGSRPVGDLMAILPAFKTERDCFVWSQVKKAISLILSGISNDIQAVAAVKAYSQQLLSEVKSEISWTGQAESYVNGEFEKNIIQLSAMADDEDVVREVKCRFRSWKSGDHGSINRNLQAPIFGISVAKGGEEEYLDVKAEYIRNQSIDGREICIAAMGRTSISTMARDFLDFTFLSEDNIPLQNVHFVAIALANGPCSSVLWEYTKENWETVYKRLSTNSVALTLFIESGLSCFDELAVEKDIADFFAAQDIPGIENPLQVVSDHIKMNAAYKTRAASEIRPWLQANGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDC2</accession>
    <name>A0A0D1YDC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233172.1">
        <property type="nucleotide sequence ID" value="XM_016382469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDC2"/>
    <dbReference type="STRING" id="91928.A0A0D1YDC2"/>
    <dbReference type="GeneID" id="27335226"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08143"/>
    <dbReference type="HOGENOM" id="CLU_1019430_0_0_1"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW12956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="267" mass="29462" checksum="1E76C70930DEF35A" modified="2015-04-29" version="1">MFFIVPDCKNPKGDPSSAPGTSSSPSEAPKRQRTSPESEEVAGYYPRRNQKACDRCRLKKARCSGGKICEKCKRDGVICTTNRESKRDPTTKPPNAEYVHLVESQRDALLNALRAIYEKDASKDSTILSDVLKDLGIGVEDLKRLPRRTTAQDAPVDYDDIDLHRNAAEIQALLAEWNIPITQSETSANFPTSPQRYSNQSGQPKNSVPLSMSNSLQYLAPAASASSIVEDLDSITMPTSVNDFDDWLVTDKFEDDWPSSVSGYPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDQ8</accession>
    <name>A0A0D1YDQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233392.1">
        <property type="nucleotide sequence ID" value="XM_016382689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDQ8"/>
    <dbReference type="GeneID" id="27335446"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08363"/>
    <dbReference type="HOGENOM" id="CLU_014855_0_0_1"/>
    <dbReference type="OrthoDB" id="5593352at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039712">
        <property type="entry name" value="Meu6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039483">
        <property type="entry name" value="Meu6_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073:SF1">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15406">
        <property type="entry name" value="PH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="69"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="632" mass="67607" checksum="83A75D9D4118D769" modified="2015-04-29" version="1">MSVEAPKPVEETPVVEPTTKTLPETPVEPSTAPAEPAAEAIPAAPADETTEAAPATEELKKDETVVTAVPASEGVLGYKEPTSLKRFFYTKHFFWFSEEASTPESLATFLRSEKADAKHASASWARETGKGLLFFAKRAEDKASPVGIINLADASNVTKEGFNQFSFKAGSHQHRFEATKAEERDSWVVAVEKAVEEAKALKEEITGRESYKKSVEEYSKPAVIAAASTRSKSKEPKKSLEVNAATAAATTPAAESTSPSTETPEEPKKELKERSQSRKRGSIFGSLIGKKEEHAEKKEMKEEKKEEAEAKEEAKATEEPSEAGEAAAVAPVPAVAASTDKKEEKEEVAAPTEKKNKRASVFGTLFKKNVTSPTTEKTEKEATGSTDVPPVSETAPKLEEPIENKPIDTAAVTAPVDAVETPAEEATKEPAAVTPESSAPKTEKKGGLLGFIKKTEAKLEGKKEHKEEAKEETKEEKADEAVAKDPVPAASAEPATETAVAEPATEAPAAKEERPARDNKRRTSLFFNKKRETASDAEEGAEEPKREKSPTPAKFIGNLVRRASKAVKSEGPKEKEKAPEQAPTAEETTEAPAAVPETAETEIKGDVVPSDLVADKPEPAVPAAAPEVKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIZ6</accession>
    <name>A0A0D1YIZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235127.1">
        <property type="nucleotide sequence ID" value="XM_016382025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIZ6"/>
    <dbReference type="STRING" id="91928.A0A0D1YIZ6"/>
    <dbReference type="GeneID" id="27334779"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07696"/>
    <dbReference type="HOGENOM" id="CLU_031896_0_0_1"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="492" mass="55564" checksum="42614AFC6C7B0A86" modified="2015-04-29" version="1">MFTYSSEQFYRDWRYKVVEDFKTDDGDTYPYVEGGHVEWGAEDHKLTLPTKPSKVAINTDASILAVAVEHDIHVFSTEDYRLTQVLKGHISRIDTLAFQPGNPNILVSAATNDHAGSVRADCEIIFWNPKQRQAQKDALQLSEICQEASDNIAASIAKGSDSIELADTEISKLSEDIEQLVTTLVTRHMVSDEARIAGRLLSHFDTHLFDPSGTRLMYLPGNRPRSNSDARWDMRVLSMQTREDLFTLVGHTDAIMWSGFSPDETMIGTCCWDSTMRIWDSQDGSLKFKFETGKQNWNGSFSPNSKFFAGTAGDGTIYLYSTLDGSTLWSRQSEIDWCRHSSWTPDSRLLAIGGRRTGTVLVINVNENTVVQRRVLSIDACKVDEERKKRLLRSYLEVYAVRYVDAGKKLAVYTGGDGGIEVYDFEKQQKWRFARFGTDEDLHPCDADVQPKGSPGLDMIAWNDLKNGRIKLTSLDDNNVRIWSVPLDHESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKD6</accession>
    <name>A0A0D1YKD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235652.1">
        <property type="nucleotide sequence ID" value="XM_016379825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKD6"/>
    <dbReference type="GeneID" id="27332565"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05482"/>
    <dbReference type="HOGENOM" id="CLU_566180_0_0_1"/>
    <dbReference type="OrthoDB" id="4136242at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="483" mass="53384" checksum="F6381688B177D28B" modified="2015-04-29" version="1">MKYDPDDDDEAVFCSLATRFGRQLEDVKHAYTTASRNVCTVLRRQYFNTVHATPERPLCRLLSEDVLLKTLGSLPLEVGLMTLARIYDECHVALCKTLAAARRGRPYHELFKRNPCVDLQPLHDLLRQHSDAVDNQVVLEATSSEEIPMRAVWRPMLDMCFDSLPRLRSLSSFLPGENSSSHEYAGVGGGGGSDIISASLLGHLLKRYHKRMELLISTRTWATGSQGKKGSKLGIKREVYQHDGPAPGADGRPVPGTFRVKSDTYAEGRDLEAIPLQYHEKIFMVLDQGESTSDIAEKERADLNEQFAAVLRQASRPIDTVLIVDTGGDVFGADKAGGTTPDQDFRVQRAMAALSSKYNLVTAVVAPGVDAPEDAAIKAMDAGGKVYKPTTEEQAMLLDLLVNRYKMDGSDPSRFGKTILALQARLKGVIGWTSLDLPAYVVDTWDNPWNSFVYIRECMSDIILMPTIRLLPLIEPKKTTSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNU8</accession>
    <name>A0A0D1YNU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03991</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237017.1">
        <property type="nucleotide sequence ID" value="XM_016378340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNU8"/>
    <dbReference type="STRING" id="91928.A0A0D1YNU8"/>
    <dbReference type="GeneID" id="27331074"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03991"/>
    <dbReference type="HOGENOM" id="CLU_043547_2_0_1"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="33"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="455"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="483" mass="52950" checksum="3A8796ECB5B498D2" modified="2015-04-29" version="1">MDDPGPDVHNFSPTQHRLPTVSGVEALKLASEKAKSISTGLPTLDGLLLPNELSLATPGLQRGCVTEIFGPPGVGKTAFGLQVATNAMTSTHDESHVLWINCGSPLTPNRLRQLMAGHRQTQDPKLSPPGALNPPDTATLVSERFTYLEAHSLPRLLTIFLHPSQTLPGSKTSLIVVDDLSNLILGSFSRSAKHLKPGAPAVVKEKFEKRAAGRRFQIIESLGAAMSKMATLGRLAILALTNSTISLKTGQKAMLKPALSSQAWDTAINTRIMLYRDFPDKDQEPQLSKLETRALRYAEVQRLGRKETRGPPVAFVILADGLRQLHPPEPHDQEEEDIFNAFHGTEEQRRPPQIHLPLLPDEISQPPQPKKRKATEIADSEDEEETDDGDGDGDERNGKADASVHAEPKLPTLPTLEKEIIIKKEEEEDNDDDDEMILDAHEAALLRSYRHAIIRGSEDAIPISSDEEEEEGDDDDEDEGGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQC6</accession>
    <name>A0A0D1YQC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237657.1">
        <property type="nucleotide sequence ID" value="XM_016378980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YQC6"/>
    <dbReference type="STRING" id="91928.A0A0D1YQC6"/>
    <dbReference type="GeneID" id="27331718"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04635"/>
    <dbReference type="HOGENOM" id="CLU_043678_1_3_1"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000008">
        <property type="entry name" value="Ulp1 protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="221" mass="25381" checksum="492AA361C68D1719" modified="2015-04-29" version="1">MAPKLAPEDAYLSLTREDISVLKNDWLTDNVIAFWEEYLEREYLVNFKHSHIVLLRPTMSFMLMQTPDPRTIKDALPDLTNVSHIFLPINDNHAVNVAEGGTHWSLLLVSIVDGVAFHYDSMPPGNQFEAHHVTQKLSRLINRPLKFIHLHDSPLQDNSSDCGVFVCLNMRHLLLKRLLMVRTDAKVSMSLGGRKVDATAGRKEMLRIIDEFRKEGERRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQW5</accession>
    <name>A0A0D1YQW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase-assembly factor COX23, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237822.1">
        <property type="nucleotide sequence ID" value="XM_016379145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YQW5"/>
    <dbReference type="STRING" id="91928.A0A0D1YQW5"/>
    <dbReference type="GeneID" id="27331884"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04801"/>
    <dbReference type="HOGENOM" id="CLU_157422_1_0_1"/>
    <dbReference type="OrthoDB" id="9971592at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13931" checksum="5A16BE3F16946D20" modified="2015-04-29" version="1">MATTAESDQSAGQEVNWKKEDKAFQAKRTSEYYDPCQEAANKSIRCMNRNGGDRDMCQDYFQYVDRPTQPTNTCPLNEALISLLLARPEELTVSTENRAYRDCKKEWMARRKAQSKSWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRU2</accession>
    <name>A0A0D1YRU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238167.1">
        <property type="nucleotide sequence ID" value="XM_016379490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRU2"/>
    <dbReference type="STRING" id="91928.A0A0D1YRU2"/>
    <dbReference type="GeneID" id="27332229"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05146"/>
    <dbReference type="HOGENOM" id="CLU_019414_0_2_1"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="410" mass="46425" checksum="46C11BB3F6852C7F" modified="2015-04-29" version="1">MASVPGSSNTSSNRPERYRVAIPEDQLNDLKSRLARTKLPDELEGSGWNYGVPLSDIRRLIEYWKNVFDWRIQEQKLNLQPHFHAPITVDGGHGTLDIHFTHWRCQSERAIPLLFIHGWPGHFSESSKMCPLLTDSSRPGPKFHVVSPSLPNFGFSQAVSTPGFGIKQYAEICHKLMKNLGYHSYVTQGGDWGFTISRAIGMLYPESCRASHINMVPAKPPTLLSNPWKYIKTLTTPLSRADKNRISRHQQFLETGTGYSVLQSTKPQTLAYALADSPVALTAWIWEKLHDWSDNYPWTDDEILTWVSIYWFSTAGPGASLRIYFEFNSARDPSLSEGYFSGWVPEVKYGVAHMPGEIVDAPSLWTQTLGDVIYESEAEYGGHFAAWENPEFIAEDVKNMFKGLKESIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRW0</accession>
    <name>A0A0D1YRW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sterigmatocystin biosynthesis monooxygenase stcW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238182.1">
        <property type="nucleotide sequence ID" value="XM_016379505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRW0"/>
    <dbReference type="GeneID" id="27332244"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05161"/>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="68444" checksum="7C3258C916A53C7A" modified="2015-04-29" version="1">MVSNDTWFGAVSEENVENPRLKDLPPLYHHCVDNFRPVKVICIGAGFSGILTGIRFPQRIPNLSLTIYEKNEEVGGTWWENRYPGVRCDVPSAAYQYTFESNSQWSEYYCTGGEIEKYLIRVAHKYGVYKYIKFQTEFSGATWSEDEGKWEVKLRNRLTGREFTDICDFLITATGILNKWKWPDIEGRETYGGTLVHSANWDSELTMDRMKGMKIALIGAGSSGIQILPEIQPIAKHVDHYMSGKTWISPIGFGSQELENRGVTGNFKHTQEELDLFKRDPQAYKAFRSKIEIMVNAAALVTLFGTSAQKQFKEVNREAMRKKLEKKPEVMEALEPNWPPGCRRLTPGPGYLEALVQDNVSFIPTKIKRFTHNGIETVDGVEREVDLIICATGFDTSLKQPMPIRGRNGVSLNEVWDPTPEAYMGIFPPQMPNMMRYIGPNGAAGTGGLIKVIESACEYMIKAVQKAQREYIKALVPRNEVVAKFSKHIDQYFTKTVYTQPCRSWMKRGKEDGRVVTIWPGSALHASYAYENPRWEDFEYTPMPETEDNPLYFLGNGLTILEEQGKHTADYLDTVDKPPVINPEVDIEATGEQTKTGINGGASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YS65</accession>
    <name>A0A0D1YS65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lignostilbene-alpha,beta-dioxygenase isozyme I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238282.1">
        <property type="nucleotide sequence ID" value="XM_016376712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YS65"/>
    <dbReference type="STRING" id="91928.A0A0D1YS65"/>
    <dbReference type="GeneID" id="27329436"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02353"/>
    <dbReference type="HOGENOM" id="CLU_016472_6_2_1"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW18066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="64541" checksum="196393AD7E9D5374" modified="2015-04-29" version="1">MAHIFDLAPQLTGSNYTNGVRSSDRVVYPATGVFQGFNKPSRLEGDIFDLEIDGVIPPEINGTFYRVQPDHRFPPIFEDDIHFNGDGSVTAIRIANGHADFRQRYVHTDRYKAETEARRALFGRYRNPYTDNETVKGVIRTVANTNITFWRGMLLASKEDGPPYIMDPVTLETIGRYDFEGQILTPTFTAHPKFDPDTGEMLCFAYEAGGDGHDGSNDVVVWTIDRDGKKTEECWYKAPFCGMIHDCGISKNYLVLPLTPIKWTGIDRLKKGGNHWAWDPHEDQWYGVVPRRGGKPEDIVWFRADNAFHGHVAGCYENDDGHVVFDLTVADGNVFFFFPPVDEKEAPVAAKRNQLRSPTCRWVFDPKLKTGTRVTPAETWTTNGEFSRIDDRYVTKKYNHFWQAKVDPTKPYDFAKCGPPAGGLFNCLGHYRWDDRTEDVFFAGPTATFQEPSFIPKDGGAEGEGYIVALMNHLDVLRNDIVILDALNVARGPVAVIHLPFKLKLGLHGNFVDQRDIDEWKGRRSESGDVGPAHPAQDPLPWQVRQQQGAASSLHNGGHLGVNGIETNGLDNGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YT60</accession>
    <name>A0A0D1YT60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Heavy metal tolerance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_02759</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238687.1">
        <property type="nucleotide sequence ID" value="XM_016377117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YT60"/>
    <dbReference type="STRING" id="91928.A0A0D1YT60"/>
    <dbReference type="GeneID" id="27329842"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02759"/>
    <dbReference type="HOGENOM" id="CLU_000604_6_0_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="237"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="550"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="809"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="839"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="905"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="938"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW18471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="950" mass="106195" checksum="1BF9570467ECDBB7" modified="2015-04-29" version="1">MSLRFNELNVVRGLSIVLAFSYHVIACCYALFNPCWSTGRRMRKVQIMFCGLVVLSTCAQTIIAIRNSNPALTNDPEVLYSLFVTLIWGILLLETVDASSGISYPQYGVWVILLLSESAILTLQVKNEHRSNPLSPANVILEVVRISLTALLSGSVFVAYYRDGNEIGTDEETQALLGDASSRPKSDEVGKSKKTDQDELDRLEIRNRPRWQYLASFKIFVPFMYPKGYRNQTFLGAMLLTSLVERIVMVVLPLTLGAVVSGLGSHIPWAAIGLYCFLRFCSSAAGLSLLETYLSYQVVTDMTIALNRHSYDHIMNLSADFHDTKKSSIIWQTMHQGQDVINFFKDIIFDFAPTVIDFGAAAVVLTIMFGPYMLFVIMTTTIFFYWLTFKALARNRELSRVSLDAWHDQYYQLTESTVNWSTVSHFGRLPYEKQRYREKGDANRAADMTYFAHASWSRGVRYSILAINFVAACCVGALQIAYSDRKVGDFVILVTYWTQLTYPLDTLAYNLARISQKMVNAEKLLVLLEKSPRVQDVPESKVFTFLAGAVGFENVTFSYDGHRKVADDITFRAAPGQTVALVGRTGGGKSTLLKLLFRFYDPDQGRILVDGQDIRQVKMESFRKHVAVIPQTPVVFNMTIMENMRYPDLECTDEDIIEACKAAALHEKITTFTNGYQEQIGERGTKLSGGELQRLAIARAMLKKANILLLDEATSAVDSITEKQIQASLRKLCAGKTTFVIAHRLSTILHADQILVIQDGRVVESGTHNTLMKANGHYNELWSSQLQMQATDTGDQSRSRSPREKEHFLLVNDSGGKEKNTGSLAANVTRQMDDDARQSRASSKGSSKSHQASNNDRGRTKARRFARSLSRTLSRSKSPKDLARRRKSLKPETGSPPRDELAAHTAQSLSSSGRCDSDTTNHSLHSTQSNPRSEKSNHSQASTSNFVEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUH8</accession>
    <name>A0A0D1YUH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239127.1">
        <property type="nucleotide sequence ID" value="XM_016377557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUH8"/>
    <dbReference type="GeneID" id="27330283"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03200"/>
    <dbReference type="HOGENOM" id="CLU_479819_0_0_1"/>
    <dbReference type="OrthoDB" id="4143981at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="575" mass="63608" checksum="6A61C9248429A150" modified="2015-04-29" version="1">MQNPKPQVTVSFSVPNHPLRSLPTNIHNGARFPKRTIAASPLSKEIPQLSPESQRPSLRARNSVTSRASSVPSTPLDDIPRPLWERTFIRTATTPEATSPELSIEEITSTKLSLDDEEFLTSLPDSENYKQAKLGISCARKCTVDIGEDRPGRWKKMRRTLRKIPNDLFAWKSRPSTPVKRELCVDHPATTESLLPEPELLTESCVPPPAKSTDVQEPDKEIVEPLVLDYDGMPKGSVSRSEELSQVSRRIREELKDSSRMQTSSKSTDPPPHFRGPFLNQRTHKLSSKARVAATHLYGQRGLPPDFPPRRRRLTDKPTTSARGEGAHRYSVSIHRPRRPSLSNATIGQNSAASIGRTSRPSSRPGTNAESNKSISGRTAVPRPMVYMDGAISSSTILWDHGFVRQRPSTSSTTRPAPNSASRPTTRAGAEPCAVRSPAPEIEMGGRDIPEWAKVPTFVPRTVRAPRRTANQVGLSGDTAPLKPAREESDMDGFQPELNLSDTAISDVSFASLHVQTSNQSSLERQAVLRNKENEFEVPQRTSAKSRERISQLLATTWKEGNNKIRRMALQGPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWI2</accession>
    <name>A0A0D1YWI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239877.1">
        <property type="nucleotide sequence ID" value="XM_016374601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWI2"/>
    <dbReference type="GeneID" id="27327318"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00235"/>
    <dbReference type="HOGENOM" id="CLU_084257_0_0_1"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3620.10">
        <property type="entry name" value="YdcF like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051599">
        <property type="entry name" value="Cell_Envelope_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
        <property type="entry name" value="INNER MEMBRANE PROTEIN, PROBABLE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="123"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="282" mass="31081" checksum="BE581894FE82AFF6" modified="2015-04-29" version="1">MDLPYSESTVADINTIAEFISCEDISSLLTCPPVDVLVLCGNSILPIAHHVFSALETRPELARTVVICGGIGHSTKFLYEAVRTSPRYHPLSSAVQGMPEARVLQLVMERFYPRISDHVRSGALVIIVEDASTNCGANAVETRRVLEAHGVSEPATFIIVQDPTMSLRTVASFKRAYAEVSPAPSFSACPTFVPRTALDGTTTQRPHFQVPGIQESELWNWPRFTDLVMGEIPRLRDDEHGYGPRGRHFIAHVDIPDAVEAAWKRLDETLGHLAMRKVAPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZN0</accession>
    <name>A0A0D1YZN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240992.1">
        <property type="nucleotide sequence ID" value="XM_016375716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZN0"/>
    <dbReference type="STRING" id="91928.A0A0D1YZN0"/>
    <dbReference type="GeneID" id="27328437"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01354"/>
    <dbReference type="HOGENOM" id="CLU_011918_1_0_1"/>
    <dbReference type="OrthoDB" id="289228at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="349"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="633" mass="69889" checksum="309CB2FB9A433B54" modified="2015-04-29" version="1">MGQSQSAEPTTEVPIEQLSHQLALRFASKCFSSLEIVHYKDNFKSLADHQDDLEYWKEDTLCRFLALPEPLHAGPVVYQMCTYLGAFPFPRLAPCILTRENMLKVITIMTGRYKKVLRRGDQDKAKLLFRSLAVFDRAASTALSTKEKPSMDHVIREQLPEDMLEQREAAEGPRTHPSGFAIDEPLNDDEDEDDDDLALAALDSLDAIEVFKHDQKTDRKIHHAMIPVENFKKLVMLLLLMSGIDPLTPLGSYGESLNEERLQALSASADSIIAAFDPGPETKGIRYPNFVKTVTTTLPELFDPFNNLFEHFLFSKNINLNKHRNLPDPVPNQDTKQSFIYRSPEDDTTIFTDTLLSQLSMTLKVSNPSGTLMNIFPSGAHFNRLYSSSSDGTSLSSFSRQVTSWQSGSLLLVSGTTLDDANQVITLGAYLPGRWHDSTSNSNPNIPSSHDQSAPRPSLVQLHPRQALFPGNPYNRTLSWLHFSTRTGIALGCVIPQRSRTSAAPQPPILGPVSLLIDSDISTATFQHDGSAGSGAFVTDPGLETAQTHHPDTAQAKKIQFDIDALEVWGISFPTGTGEDEITKQKNRLAWEEAEAARRRGVNFGGDKDGARALLEMAGLVGDQSNQRSGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0H3</accession>
    <name>A0A0D1Z0H3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241312.1">
        <property type="nucleotide sequence ID" value="XM_016376036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0H3"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0H3"/>
    <dbReference type="GeneID" id="27328758"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01675"/>
    <dbReference type="HOGENOM" id="CLU_047725_0_1_1"/>
    <dbReference type="OrthoDB" id="4132605at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35961" checksum="828AC149FFE61960" modified="2015-04-29" version="1">MSNTSVITLDSTVPAAESSSVTIKTEGENKPALSEYNASSTSSSELVAAICRDGGVIVRNFASNSTLGALEQELRPHLEADEGYEGEFFSKETRKAQGLAGRSPTFCKDILANDLWRGVYETFLTTTTKSWTGDTLHECVSRPQLSSCAVIAIRPGGKAQPLHRDDMVHHVDNPAITADQYQIGRDTSVGLFLAGTKTTRKNGATRFQPGSHLQATINPPNEQDSVYAELEAGDAFMMLASCYHGGSANKTADEERVVYIHFMIKGYLRQEENQYLAVPREQLLQYPEFVQRKIGYEISEPYLGWVNLADPLKFVKGEETQMSDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z9V1</accession>
    <name>A0A0D1Z9V1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230003.1">
        <property type="nucleotide sequence ID" value="XM_016386195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z9V1"/>
    <dbReference type="GeneID" id="27338970"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11887"/>
    <dbReference type="HOGENOM" id="CLU_015771_2_0_1"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="76033" checksum="5188A3B3486DE504" modified="2015-04-29" version="1">MSLIPGSDVFSSSFCTADARPVFVINPTFSISLRETGRSENAFLQVTFYQEGRSFLSDLANSGAKAHPIGESLFHNPRLYLLPTFSQRLWHFHPGVFHPAQDFKNLLFWIFQALKAYSAGSRDRMASGTDTKLLFIPYRPPRGTKQTPAVSGISPQKHAAREYHRKAKLARLARAYANSSQHMREPGTALHAESGLRSQRQAENETLTSRLDTRLDKENAFPFRTEGSHLSSPLDVGVGQLDPFNVLIRPNVPHYVQEMLDHAVSHQWPVFSCSIAATAISEIKHTILASAMRSPAVFYTIVFAGATHNAFAHTGMQITRENQVLRLTYKTHAIRALNQEISRTQKSVSDELLLCMVTLGFHGSGETLMPRAQAANDSPLLVAQNFHFYGHMDWETAHLNAVKTMIKQRGGFHTIEQEFLSNVIALADVIDAFKNLTAPTYPLRITTARLMAIWPYPAPNTVPHVLRMMTTGFATLPPSVQRDPLMWTIETIRDVTIGYDLSRRNDPTAPRHIHVVWARNTLLHDLLRLPDRTWDNPRSCDLCVYEICRLSTLAYMLLVLFPLPRISGLHYALAQRIKHALDGCLIVGLWESHPELFLWATILGGILAEATALRPWYGQLGVKLCQELDLSSWHDLKRICLTFLWYDQDCERLGEEFWGDLGMYTWPNLGSTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z9Z7</accession>
    <name>A0A0D1Z9Z7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_11948</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230063.1">
        <property type="nucleotide sequence ID" value="XM_016386255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z9Z7"/>
    <dbReference type="STRING" id="91928.A0A0D1Z9Z7"/>
    <dbReference type="GeneID" id="27339031"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11948"/>
    <dbReference type="HOGENOM" id="CLU_011409_10_0_1"/>
    <dbReference type="OrthoDB" id="4118594at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW09847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="586" mass="64984" checksum="382C7F1DB09B64E5" modified="2015-04-29" version="1">MNNSQDAVVPEPNSPPQSAMQQSERSRTKKWAPKTFNGCLTCKKRRIKCDEGKPFCQRCLKSNFECGGYAPPKIRLFEPTGISSPSSSSAGPSSIAPSPLPGIPTTSPPPENPQLHSYLNSYPHPQELALVPSFGTEDEYRSFQFFIEKTASLISVYSQPYLWTVVLPQATWQQAAIKHSVIALANLHQSLTASSGAAGGSPTQAGHDSVVTHYNAAIRALLTQKPPIDVVLVSCVIFWSLENFNGSEKAAFDHMKAAIKILGEWKTNKRRRRADDPAHDLISTYIEPTIRDVVRFAPVARLEELEGQIKSVGLSSQDVRVINHGLGQSFETLKDASTYLSEGIADILSLMALASSMDHEGADVPPENVVESVNELDAKLYKWINLFQKLTSTGPVRARRMLVVHHVSAYILLDLAKDQLGMSEEEVPQQLPRCRWSFIVNEVEDMLKHGQGPVQKDKCSRLFASLGIIPPMFLAATSAPNAEIRRRATNAIRLMSVAAEGPWNSEVAAKIADAMLEILSMQRSLAPSDVTLKQMRFGVDTRRSRLYLRWNGENHHVDKEMEIDEIRPVDPKLPEVIQHFGYCVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAB8</accession>
    <name>A0A0D1ZAB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230163.1">
        <property type="nucleotide sequence ID" value="XM_016386031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAB8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAB8"/>
    <dbReference type="GeneID" id="27338806"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11723"/>
    <dbReference type="HOGENOM" id="CLU_023111_1_0_1"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237605" description="Acid phosphatase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW09947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="51944" checksum="A17E22DAC81B14ED" modified="2015-04-29" version="1">MYFLHLLTSLALAQLATSQETVLGVYIFSRHGDRTAKSTPPANLTDLGYQEIFTSGTYFRNRYVATGADRRIFGVNSDLVKQSQIMASAPSDTVLQNSALGFLQGLYPPVGEELGSNVLRNGTRVQSPLNGYQLIPLQSVQTGSNSEDSAWLQGSTNCANAMISSNNYFTSAEFLETFNRTQSLYQKIYPDVARTFTEEQTSFKNAYVVWDLLNVASIHNASVPLPDDADFFQLKTLADQHEFGLAYNASEPIRAVTGSILAAEVVSALNSTIAGHGKTKVNIQFGAYAGMLSFFGLSNLTSVNPDFFGVPDYASSLTWELVTNATVTSSSWPSVEDISVRFWFHNGTTSNTSEPVEYPLFGSNRSPLPWNEFVDGMNKFAISGQAAWCQACGNSTGVCSAAALDADGDDSTSSGESTRNDNGNGNGISKAVCGVIGAMVTLGVILGAELLVMVVGGFRLVNKKRLQHPTTNGVAEGSFGKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZC94</accession>
    <name>A0A0D1ZC94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230863.1">
        <property type="nucleotide sequence ID" value="XM_016385919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZC94"/>
    <dbReference type="STRING" id="91928.A0A0D1ZC94"/>
    <dbReference type="GeneID" id="27338694"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11611"/>
    <dbReference type="HOGENOM" id="CLU_2427056_0_0_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="91" mass="10281" checksum="D90E662147570613" modified="2015-04-29" version="1">MGRSGIFRAVKTRRHNKPPDEKNAVYAKPNPEDGFIMLSSCYHGGSTDNRTDEERFVTSCFMTLDVAKCLPIPVQKLMGYTANEVSQRLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZER0</accession>
    <name>A0A0D1ZER0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase</fullName>
            <ecNumber evidence="9">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_10742</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="9"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231658.1">
        <property type="nucleotide sequence ID" value="XM_016385056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZER0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZER0"/>
    <dbReference type="GeneID" id="27337825"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10742"/>
    <dbReference type="HOGENOM" id="CLU_028288_1_0_1"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000002">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW11442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="526" mass="59059" checksum="B52BAB247ED25523" modified="2015-04-29" version="1">MGIKMPESSSPRESSPANGDNVTLPDAPLLANATGNALGPDMQDQSKVALEDLFDDDDSDLEDEILASEAANLPSSPPQTAPNSPTNAASVSQQESYSDPNLMLQFYSRLFPFRSLFQWLNHSPKPGPDFANREFALTLSNDAYLRYQSYPTADTLRKDILRLNPSRFEIGPVYTTNPRDRKTLKKSSMFRPLSKEIVFDIDLTDYDDIRTCCEKANICSKCWSFATMAIKVVDVALRDDFGFEHIIWIYSGRRGVHAWISDKDARELDDDKRKAITGYFEVLKGGVQGGKRVNLKRPLHPHITRSLDILRPYFQQVLVDQEPFMSQSGQDRLLQLLPDKTLNEALAKKWASSPSRPSARKWADIDALAETGVSKTLNTKALLEAKQDILLEYTYPRLDVEVGKKRIHLLKSPFVVHPGTGRVCVPITAAGDMKRAEAFDPLSVPRVNELLKEVDDFGSGDDTGTINGFVEDGVTMRKLSDWEKTRLKSYVELFDNHIKALMKSEMVRVKRERDDDGVTGAEGMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZFS0</accession>
    <name>A0A0D1ZFS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">7-alpha-hydroxysteroid dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232058.1">
        <property type="nucleotide sequence ID" value="XM_016383435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZFS0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZFS0"/>
    <dbReference type="GeneID" id="27336198"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09115"/>
    <dbReference type="HOGENOM" id="CLU_010194_17_0_1"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26675" checksum="BD4A76F6621E7125" modified="2015-04-29" version="1">MSSQKAWAVVAGVGPGTGASVARRFAQNYSVALLARNPANYEPLIKEIEAAGGKAIGISTDCSDSKSVKSAFEQLKKETGGASLAAAIYNVGGRFVRKPFLELSEEDFEAGWEANGRGAFLFSQAVLPLLLDTVNRSPEHPPTLIFTSATAAMKGSANCASFASGKFAMRALAQSLAREFGPKGIHVSHAIIDGVIDIERTKHYHFDHPDAKIKPEAIADSYWYLHTQPRTCFTNELDIRPYIEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZKW9</accession>
    <name>A0A0D1ZKW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233678.1">
        <property type="nucleotide sequence ID" value="XM_016382975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZKW9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZKW9"/>
    <dbReference type="GeneID" id="27335733"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08650"/>
    <dbReference type="HOGENOM" id="CLU_108113_2_0_1"/>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19118" checksum="28C20A38C0DB8F26" modified="2015-04-29" version="1">MSDLATTLRSTAERYISAFKTLDADLFASLQSPKEYKHTFGPASVNPPPPQDGARFAQHIRDLQGIMKGFPVRARSTWVNEAQRQVIFHATSETWFRDEYKDSDDAEWLYHGEYVFVLDMDETGQKITKVFEFLDSKGTEELRGLMKRARAKEAEVKGKDVSKTSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZMU1</accession>
    <name>A0A0D1ZMU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_06923</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234358.1">
        <property type="nucleotide sequence ID" value="XM_016381256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZMU1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZMU1"/>
    <dbReference type="GeneID" id="27334006"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06923"/>
    <dbReference type="HOGENOM" id="CLU_006504_3_0_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252956" description="Laccase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="202"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="352"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="571"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="82078" checksum="7678EC2D07BFF120" modified="2015-04-29" version="1">MRSLKYFAALLPLCSVGAFAGEWEEGDVIVEVTTTRTVTVCPLTEFYTCEADTLPTKLPWEDWTTTPGDAETTTTTTTGSEGSSTVTSGSWGSSTTSGTGYWSTTQAPTGSTTSAPHYGNSSTTSYTSITSSASFNTTSSTATLTTTTSSVCKNETSRATGLPEPRCNGPDDRSRWCIGKSVDDDTHKTFYTGQTKKYTLTITEEQLDYDGTLKHSFAVNGQSPGEAIVANWGDMVEVTVVNGLTTNATTIHWHGIRQTGTNDQDGVPGVSECGIAPGAARVYKFHASTYGTGWYHSHTLSQYGAGCRGPIIIHGPATANYDLDMGSVMIDEAFNQTIFEMAYNIARVRGALPPATNYLLNGKNKSPDGTKGESAQWTVKKGKKHLFRIINSSAQSAYAVHFDNHKMKVISADFTPVVPYETDVLYIQSGQRYNVIVEMNQPEGAYFLRAVTQQGCGVRSLNDGLGTSNGVFTYEGSCGTPKSDNFTISTASDCLDEPLAKLIPHDSKSAGSVSQFQDTVKLLPAGNAGSQNFGEYGPVIRWFMGELKELSENSGTPAANKAINVTYSEPTLKTLATLPGLGYNSSYFGNTAVLDGPANSWVYFVIQNNFQTSHPMHLHGHDFSVLGQGKGVFTSDMVGQLNFQNPIRRDTVLLFGAGSPQAFVSGWTVIGFETDNPGAWIMHCHIIWHADGGMGLQFLERPDEIDAKGYYDSEFKDECASYATYEASSAPRHPYESGLKARHLHNHKVSHRNVVRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZXG8</accession>
    <name>A0A0D1ZXG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_04566</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237588.1">
        <property type="nucleotide sequence ID" value="XM_016378911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZXG8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZXG8"/>
    <dbReference type="GeneID" id="27331649"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04566"/>
    <dbReference type="HOGENOM" id="CLU_049413_3_8_1"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000010">
        <property type="entry name" value="Acyl-protein thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="13">
        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW17372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="234" mass="25739" checksum="5B29D1F03C66A38C" modified="2015-04-29" version="1">MAGRQALVVPALKRHSATVIMAHGLGDSGAGWISLAESWRRRGKFEDVKFVFPNAPNIPITVNMGMSMPGWYDITDFSDLNQQQDETGILRSRATFNKLIADEIGAGIPSNRIILGGFSQGGAMSLFTGATTPHKLGGVFGLSCYLVLADKIKDFAKEAGDANKDTPFFMGHGDSDQVVKYKWGQQTAEFLRKEMGHKVEFKTYRGLPHSADPQEIDDLEKFIKECLQPVNESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYB5</accession>
    <name>A0A0D1ZYB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_04832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237853.1">
        <property type="nucleotide sequence ID" value="XM_016379176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYB5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZYB5"/>
    <dbReference type="GeneID" id="27331915"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04832"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF38">
        <property type="entry name" value="PROLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="63"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW17637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="560" mass="62068" checksum="F5EB4F184B213649" modified="2015-04-29" version="1">MSSGENMDPEKGPGEEIKQDTYDGVDRKHSLADRKSSVAGSVIAAGLLDERYLTTKRGLKSRHAQMIALGGTIGTGLFVGSGATLHLGGPAFILASYILITVLVYCVVTAITEVAAYLPVHGGTMSYYGYRYVSRSMGFALGYLYWYALGILVPYEITAAGLVIDYWPNDVNIAVWMTIMLVVIIGLNFLPVRFYGETEFWFAGTKVILMIGLLMLSFILFWGGGPSHDRLGFRYWNDPGAANTYLVSGDTGRFVAFWQTVVNSVFPFTFAPELLVVTGGEMESPRRNLPIASRRYFYRLVVFYVLGVLAIGVTCPSNDPRLTDGGAGAKSSPYVVAIANAGIDVLPSIVNAVILISAWSSGNSFLYISSRALYSLAVQGSAPRIFKACNRWGVPYMAVGCSSLFCGLAYLNVASNGSTVFSWFVNLTNTWGMTSWVCCMIVYLRFRKACTVQGIQPIYRNWIQPYGAWVAMFMFTLLCLINGFTVFFPSEWSASSFLTAYIGIPIFFVMYFGHRVIFWRDKWAWDPAEIDMQTGLQEVIDAEKPIVIRKGWKKILYIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZF0</accession>
    <name>A0A0D1ZZF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238268.1">
        <property type="nucleotide sequence ID" value="XM_016376698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZF0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZF0"/>
    <dbReference type="GeneID" id="27329422"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02339"/>
    <dbReference type="HOGENOM" id="CLU_001666_7_1_1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF322">
        <property type="entry name" value="HELICASE MOV-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="362"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="631"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="912"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="936" mass="104036" checksum="77C178C39199D1DC" modified="2015-04-29" version="1">MSRLPLNPPIILSNQQPGGWWPLQQFTRPQRPLPGYFEAPRKKNVITVNGDVVTPRNEGPRAPTLSEGPEATGSAPEFDKTSDGVSTEWAAQPSKDQPASKLNIYAPVHVPDWLLAINESVAVDVPCTTLCHFDAEEYAAAFGPDTHVQPRDEWSVPLGLPTPDRQTPVEPPHYQDRFIALLRDEFAALEQRLLYYSLYNHRIVMWDPHQLLFEVRVPGLREDSPRVDLGDIVLVRPITVSDPRVVFSQNKVWRDHMRKKGQCHPAFEGTEYRAVVWGLNRANEAVFLRIENGSKCPQTANLKFILQVPKTMSLVSAVQSIDAALGSSDTLRSMLFSQRSDACMQEKLSAASFGIDWRDACLNFEQQKAVAAVVADRYGTVPYLVSGPPGTGKTKTIVEIALQLVARKTSAVHPHLRICAPSDAAADTLALRLSLHLDRNQLFRLNSWTRSFAEVPDKLILYSHTDSNSLFSLPPFGRLMSYSIVVTTCRDANILIEARLTNKDLAQLAFNSMRAVSPSTVEGLTTPLLHWTALLLDEAAQATEPESLIPLSVVLPLWQLPKCQLVCPQFVLAGDEFQLGPRLESHAQKTGLEISLFQRLFNLPFYADHPLSITNGLQPLTRKKLPLPRPAFTNLTRNYRSHPAILSVPSSLFYFDNLIPEFTPSSATTTSWPGWRKPNWPVLFIQNSGPDEVDDILAGDGTGVGSLYNNDEIGIVLTQVQTLLNGIPNLKPEEVMVMSPFRAQVKRIRTALRKEGMAAVNVGPLEAFQGLESRIVMLCTTRTRRGPEGDEAKFVKMDQGRGLGVIDEPKRFNMAMTRAMEGFIVVGDPVTLVCTGDTSWRNLIAFCVRNGLVEGEFGEIEEQMEGWDVKEGRLERALRRKEVGVEEKGVVGLRGFVENGEEEGEMMLPESMEGDETEDGVASEMEEVLGDDYSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0G6</accession>
    <name>A0A0D2A0G6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_02755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238683.1">
        <property type="nucleotide sequence ID" value="XM_016377113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0G6"/>
    <dbReference type="STRING" id="91928.A0A0D2A0G6"/>
    <dbReference type="GeneID" id="27329838"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02755"/>
    <dbReference type="HOGENOM" id="CLU_013866_1_1_1"/>
    <dbReference type="OrthoDB" id="4160106at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="311" mass="34167" checksum="88AE8E39C863D2A9" modified="2015-04-29" version="1">MLIQLTVSALQMISATESHHGEHGTHVRGVSAILSSGESRLDLVNGVKTFKLADPVLIGVPTKGILGAPALTSSVQSLDSTFVKMRPLISRIEALLTCTLTGWDEIKLTQAAALDLNEDLTRWEDSQPVKWRPTSMGIWSSYDSPPGDSIFWPGQVDKYFDPYVAAVWNTYYKARLIALEFIVRCSLLLQEGDSHKPEHAEAQRLAGKMISSIPFLLLKDPQRALSNPLNIQEPGPSFGGLLLMHPLYVGTRMSVVPPAMQTHMRKCLAWVGKHMNIGQATLLSRAHATVPTQFVVDGHTLIWAGMLTQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A169</accession>
    <name>A0A0D2A169_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238938.1">
        <property type="nucleotide sequence ID" value="XM_016377368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A169"/>
    <dbReference type="STRING" id="91928.A0A0D2A169"/>
    <dbReference type="GeneID" id="27330094"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03011"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_3_1"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF10">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="275"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="514"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1085" mass="123043" checksum="40502ACE47636C7C" modified="2015-04-29" version="1">MSTALRQAAVLKPEIRLAQALSEFESTLDNDQKATMRSGRSKPPPSPNDVMGLTLELDKNSSGKKRCFATRLTSLLQCLQQFSTAIDTVVGGSQSLIASGIWAAVKLTLHLALGWSSFFDKLSTLLMNVGRTCPRYQEIGILFSTSAALQRAICEYMIIVVDLCRKAVVSLQGSFFKQVPFLKSFETEFGQYDEKLRRAGHMVHSEVNLISAEGQQLEMGKNTQFRSAMAKFSKKTSEELDKARQLRRYNVKTRCLDTLSSYDYQKIWKQARRSGTINCVYEHEQYRKWFRAERSTLLWCTGILGAGKTVIAANVVEHLAAQAPNATIAYFFCRFDEAESLDSWTVIGSLISQLLLHAEREMFEDLSRDLDQGITEDRLTQNLPRLLQDQNRKYFIVLDGLDACSPQAIKAVAQFLKDLLEGNFQAQIFCSSRPGLYRELSTVLQPRHHISCSELTTEIDKFLWVVFQLTSICSATTDEEILQALSNLPHDLPETYQRILAKVDCERLIKPEIRQRIFQILSAAHRPLTLEELREAISIVPGETEWDPRRLVNNMQRLIDFCGGILNVEEEYTTVHFAHNSIKQFLLQNSLNINGLTCNVYNVDLVAAAHLMGEICVTYLNFNHLKGQLTKVEALDQQAVILPHSIVQRALPRSTVSKMALTLLKSESGAQFNMHAQLKNIADSATSKESDVLHGHAFYAYSRAHWLAHTKCLTKTSKAFKLWYDMVEGHTSSVSLPWSQRWNWAVLHDHSALIDLMYTASSNTHLHVLRKGPRDALWTTRMKSHEHLWLSVIPIPIKSHIPDAPKSEYPFALAQTSRRFTLEEILAKAHVNDRMNRLGAFEVLRRIKRATLLNFLVTRSNTQFTVFVHGGPGAETDLRIHTERRGYPLAWNIGDRSGFEILEALLRIPEVDLRSTDEEGFTALALAVRQNNTNLVKILFKAQGDRPHVQYPAWRSTRTGESLLMMAVQKRNLEMMSTILVRQPLTVNWIDKDGSTALVQAIQSSYAAGVQLLLDCPENYAVCPSYFRLYEMAQRTLLDEEVNRSSSNRIGQAGEIVVMLRRYARVNKPGAKETYTLHKSDRMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A2B0</accession>
    <name>A0A0D2A2B0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-catenin-like protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03342</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239268.1">
        <property type="nucleotide sequence ID" value="XM_016377698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A2B0"/>
    <dbReference type="STRING" id="91928.A0A0D2A2B0"/>
    <dbReference type="GeneID" id="27330425"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03342"/>
    <dbReference type="HOGENOM" id="CLU_017098_0_0_1"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="107"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="608" mass="67994" checksum="BDB3488725142EDB" modified="2015-04-29" version="1">MTSIDELFRKPNALPKRKLEDPNTTFSQALSNKSSKLTDGSSPRSNGHESSTSDPKSNGKSAFVQDEILDEKDVEAGPARPPGDDDVEDDAGDDDEGRFFGGGVTKQEREVIDFIEQNENGDVEEKIDSAWLRRTAINFERKINKNAELRAKYESEPMKFVGSEADLDSEIKGLSLLSEHGELYEEFVKLGCAGSLVGLLAHENTDIAISVCELLAELTDEDSSSSEEQWKTLVQAMIEADLIDLLVSDLGRLDEANESDRTGVYHILNVLENIFSDTQYQEVAGSKDGLMQWLLSRVKKADPTARGKVGQNRQYAAELLAILLQSNRTNRDRFARKEGVDALLELLSVYRKRDPEKDSDEEEYAENLFDCLACVVEERLPADKFIEGEGVELCLIMLREGRLAKARALRVLDHAMSGANAVAVSMKFVDAAGLKTIFGMLMKSHKMERSLLEHLIGILASLLRYLPGGTAERIRTLAKFVENNYEKTHKLVELRKEYKTRLIKTDAQIQRERQDMNEAQLEEHADEWLSRRLDAGLFSLQALELILSWMVAEDTGARETITVLLGEDGLKVLERSLRDQLDGMDAGQGEEGKATEEMLEALLLCVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A2C4</accession>
    <name>A0A0D2A2C4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239288.1">
        <property type="nucleotide sequence ID" value="XM_016377718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A2C4"/>
    <dbReference type="STRING" id="91928.A0A0D2A2C4"/>
    <dbReference type="GeneID" id="27330445"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03362"/>
    <dbReference type="HOGENOM" id="CLU_038384_4_0_1"/>
    <dbReference type="OrthoDB" id="4838853at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="416" mass="46850" checksum="4874A46D0013A564" modified="2015-04-29" version="1">MPEVVRGSRASLQLARNATPVSPTQETRAVHFEPASPAVEDTPTPGLNAVDTGLSTDSARRRSSQHKRRRTQDMSSPERAAYYDSRAATKREFRRRASTLQEYYQDHPELLPQLPFTWRHGLKRWKLFLTIFIMFVDACVIPIVLYYSMKFAGHVQGWIIFAVVATIWGGPAYVEFAVRSWRLIKKENFFRPLGTSNRWAFDITHWISSLTIAAVTAFLIIGSAPHNVWLRVLSMPGPAILYCIGGSVFLITMYSLTGRKAPFRISSTPKGGDVYPGVYYIMEDVIAVNASAGRPFREALAARYAASPRFRRMVKTQSLFWSIPAIVVAIACTVVIIIHPVSKEVAYGIGWGVPFVWIIIWAAIAIPWIRRDMHKETVTWEEDCGIVPEKKHKHAVSDLENGEATSKEPKVPEPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A2K3</accession>
    <name>A0A0D2A2K3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239393.1">
        <property type="nucleotide sequence ID" value="XM_016377823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A2K3"/>
    <dbReference type="GeneID" id="27330553"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03470"/>
    <dbReference type="HOGENOM" id="CLU_2413280_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="92" mass="10272" checksum="BCB3ED6861D965BB" modified="2015-04-29" version="1">MRTVLQVLQEVEDTRDWLPNNLVSGRELYLEDIPEGKPGHCLAVLGTSLTDIRNSANQVLKDRRKLLADFSITCPANATIQEQVESLPSEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5X3</accession>
    <name>A0A0D2A5X3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240398.1">
        <property type="nucleotide sequence ID" value="XM_016375122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5X3"/>
    <dbReference type="GeneID" id="27327840"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00757"/>
    <dbReference type="HOGENOM" id="CLU_065192_0_0_1"/>
    <dbReference type="OrthoDB" id="5538558at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF39">
        <property type="entry name" value="THIOESTERASE_THIOL ESTER DEHYDRASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32778" checksum="C5FD61AD6704C112" modified="2015-04-29" version="1">MTLPRAVQRASWTVLSANHSAFRARQYSSRASVPEANGSAISPRWLSDTKARIGKCITFGMPESLVDEAGRILRVLGRDWRELVAGSEGYLTDPKRAGLHRQNIVWGEQDSMGHVNNVMYVRYAESGRCNTMRNFAKYVDPVHRQKWEDMLTNRGIGLILKSITVDFKFPMTWPDRISVYHKLRTCPDEKTTSLILDVLILSENRQRPAARCLEESVVYDYRLGKKSPMEPFMVKELKNTFELQEAAKRENLAKVQRLEKQVRDLEKRSWDRPDAKEDFGSAQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A622</accession>
    <name>A0A0D2A622_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240453.1">
        <property type="nucleotide sequence ID" value="XM_016375177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A622"/>
    <dbReference type="STRING" id="91928.A0A0D2A622"/>
    <dbReference type="GeneID" id="27327895"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00812"/>
    <dbReference type="HOGENOM" id="CLU_061220_0_0_1"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="289" mass="32678" checksum="517F99CF84F69B0A" modified="2015-04-29" version="1">MANWNPFAKREEFTKNNLIAYKILTIISWLLLVIFGAYYTFSRPADCRHKHLCHTIWGQNSHRATPFSLNSVITSIYWVVVLILQAHYVRYLWSADKAFVTSAANVGSHFIFHNLLTFGFIMLWVRGHFWIGELLLIINLFNLTLLYFGHSTTPLFIHLPVVSAPLAWNYVAILWDGAAMVNAHSLPARIVANIFIWGILVLGVFFLLTFKDYTMGLELAVLSLALGVGQLGTHVIALQWIFAFVIAGFLTGMSLLIGAPKIFGQDRSIRQEGAIVSEDRERAPLLDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A6J3</accession>
    <name>A0A0D2A6J3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_00967</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240608.1">
        <property type="nucleotide sequence ID" value="XM_016375332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A6J3"/>
    <dbReference type="STRING" id="91928.A0A0D2A6J3"/>
    <dbReference type="GeneID" id="27328050"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00967"/>
    <dbReference type="HOGENOM" id="CLU_027592_3_2_1"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW20392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38756" checksum="7A86DB3839F3191E" modified="2015-04-29" version="1">MQYSAYSVVFSILAFTGCLACIPPLVVHIRAGNTAAIILTVGVIIMCSFNALNALLWPTAASDTWWNGKILCDIEAKLYFGQAVSFNGVLLCLFRHIASILDTDRMSLGASRRQRMVTITVEIGLCIVLPCIVMAAHCLVSPQRYWIRTIAGCTPSLDNSWPSLVLIYMWPMALCLAACIYCVRAMVRLWRHRKEMSTVLSSTPGVTRSQHIRLISFSAVLLLIYLPLDVIAFAGFMRTKWHLYSWAYNHPADWSDIVVFVPQKTVSFDRWSQTFAAYILFGFYGTGHEATRIYSFWIHSLKQGLRRGDGWKPNTMGTVGISHSVPPEASDSHVSTETFQLTELGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A6R5</accession>
    <name>A0A0D2A6R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAM1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240668.1">
        <property type="nucleotide sequence ID" value="XM_016375392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A6R5"/>
    <dbReference type="STRING" id="91928.A0A0D2A6R5"/>
    <dbReference type="GeneID" id="27328110"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01027"/>
    <dbReference type="HOGENOM" id="CLU_013290_0_0_1"/>
    <dbReference type="OrthoDB" id="5407957at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF4">
        <property type="entry name" value="DUF5923 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="200"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="745" mass="84299" checksum="DBFBC5DB81D2B9B5" modified="2015-04-29" version="1">MSFLASCCGFGRKNKADDTTPLLPRYEDDTARERALHQKIHTYQMLRALSKGYMPSNEQTIVNLRTLLASDLLNPNNRELSDSGRALIRNCRTWLKLFIQLLQHKNSEDQIQDFIWYLTKSRISLDVNDISHSASKVKARADAQAAYQSFRTVGSLLLTNSDFRLFVNDVATIGREVLADTAFSLSEAAEKTGKQLELSAEEEQAISKPGADESIQPSREDVEEAAAQKATDEIASQLKKVGTDTVESAKEHIGSDQGDTLLYRLKQVILNLRSRTDYHDSVSTISKLIQRYAIAYSRVADATISTAQEDVHTNPALDRAIRNFWELMSSFGDREQWERLEQAWNKVLSHARSDPQFENFMVDVGNTVQRMFTDPEFFDNADKKLDELKDKSARLGNESEFRTDFDQFLRQAQVTINSVMEDKDVNGLLLATRRIYSALSPPNRVVNPDLITDSIHIFLPLLIRSVQHIPIPRIEVSVPEMDLLLENLVLEPGRNVNSTSFLPYRLLVSTKNDLEIRKTHSKKTVSSTTSLVTITVNGLSVAAQDLGFWIRGHAGLVRFADEGIASFYLDERGIDISLDLEIGRERLEQILALRGVRVHIHKLDYELRKSKLSWLGWLFKPLLKHLVRRSLEKTIAEKIVEGLRATNRELVFARERLRATRIADPQDVVTFLKAVAARLTPAEDPDVYTRVGVDAPTRGVFKDVYTPGSLVKMWQEEAVKAEETVEENEETGGGWRNAIFDVNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASZ5</accession>
    <name>A0A0D2ASZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230064.1">
        <property type="nucleotide sequence ID" value="XM_016386256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASZ5"/>
    <dbReference type="STRING" id="91928.A0A0D2ASZ5"/>
    <dbReference type="GeneID" id="27339032"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11949"/>
    <dbReference type="HOGENOM" id="CLU_020680_1_0_1"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253901" description="GRIP domain-containing protein" evidence="6">
        <location>
            <begin position="31"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="GRIP" evidence="7">
        <location>
            <begin position="433"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="549"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="126"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="292"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="559"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW09848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="585" mass="65391" checksum="D2F713616949F28A" modified="2015-04-29" version="1">MASMPSGGMHTSLTLHVSVLMLLLDQKSKKKKKPKKKGTNAPDSTPTPPAEPQTPTEASGSKDGAESDGTDVEERTVPTTQTDVPEETAQEVTNGIAKPIPTEENNNITNPDTDAAARFDALVKDRDALRLEVTELRKSLEELQSKHATELETVQNDLAEAQQEKETAEEQYQTLLGRVNTIRSQLGERLKADAEELSQARTRIDELESQNTTLQERYDSRTAEVDELSSRNATLEATNAEQSKELSTLRNRLTLSQQNWHKEKEELVESEAYMREEFENAKQAMHDWEVLAMEERTLRRDLADRAADLEEQLASLREAHDKVTAERDTQSSTVDGLQRALQEIQNVRKQELKELVETNQAEQDSLRTQVSTLQAQHESMSAELETTKRDLERALPFEKEVKEKNLLIGKLRHEAVILNDHLTKALRFLKKGKPEDNVDRQIVTNHFLHFLHLDRSDPKKFQVLQLIAALLGWTDEQREQAGLARPGGGGAANTSSSLRLPGSPIVHRTPSTPSLQHHDYFAPDNVASPGTKESLSELWQDFLEREASVNNHGSAGINSSRQGSSRQASQSQSVVTPRSPSLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT86</accession>
    <name>A0A0D2AT86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230144.1">
        <property type="nucleotide sequence ID" value="XM_016386012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT86"/>
    <dbReference type="STRING" id="91928.A0A0D2AT86"/>
    <dbReference type="GeneID" id="27338787"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11704"/>
    <dbReference type="HOGENOM" id="CLU_068979_5_1_1"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF15">
        <property type="entry name" value="BLR5631 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="26"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW09928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="195" mass="20795" checksum="4BFE6C3BA6115579" modified="2015-04-29" version="1">MSPPPAPTYIRSLLGIPDTVPSVTDSVLIIIDAQNEYANGLLQVADVDSSRKVIHKLLQKYRDAKAHVVHVVHDAPAGAPIFTPNTPLAEIIDELQPLSDEPVVHKVHATAFTGTTLQNVLSELGAKNLVLTGYMAHNCISATARAGAELGYNVYVVRDAVGDRHLPGIDAELLVKVSLAELADVVATIVESKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATD4</accession>
    <name>A0A0D2ATD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230001.1">
        <property type="nucleotide sequence ID" value="XM_016386193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATD4"/>
    <dbReference type="STRING" id="91928.A0A0D2ATD4"/>
    <dbReference type="GeneID" id="27338968"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11885"/>
    <dbReference type="HOGENOM" id="CLU_009400_0_0_1"/>
    <dbReference type="OrthoDB" id="5386574at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021582">
        <property type="entry name" value="Aim21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11489">
        <property type="entry name" value="Aim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="850"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1054" mass="113004" checksum="49E8769491BE85C9" modified="2015-04-29" version="1">MSAQVAPTIPPRPTRAQQAAGARGANKLPDIPPRPVNKRLDRSVSPANFPRSPLNEPWTGSLSRQKTNESVEALPRRPSIQNLPSIGQEGMEYAEVMNMQTNLQPPSSSMAADAAAQTRNIAQDLKLHAPKPSLPKSSAAAQVQAVTRTDSSQAAQHGFGKPPTPAQDDGESLSRIGTRTSFSRPGSTVGGERRPSFQEETGPAELGLRVPINPLLGDVQAPSPAPGMSPSHTGSNGDRRRSVHGRTRSALDLLPPGSYGLHGHGLPPQDKFEKDWYAKHPEAAQHEETSGHGVYESIGSGRGAFALSRDDLNKIVRETASRGAGFGTSGETYGVPDEQIGYAASEVYISRSQANTPNSLAKTVTNSSQPVAESPLRKASFPADESIPAEVRRGRLSVSRGSDSHEAVDSEAEQEVHIQPSRRYNKITGGEETLNETVASKPYVSTDDEGDYAIEHGYTVPILAADEVAKEVGVEHLQPAISPRAERRESLYEEAYRSGDATPSSRPSSRPTSVHGAFGTAHTLSRFVSHHDERDHMHTPLEDVEEYEPLFPDEDDKKPLSHAERFKQRPNTLKQRFPSQDIWEDTPSSLYYSAEVSTPDLPAQVENPVSDEFESPEQEAARKEEPSEEERQKLLPKEERLAKSRFAPHLRDDMPTRPGLTPRFPSSDIWEDTPESHQLVTTVGSPQVDNEAESPTEAPAKPFVPPRPVGKSRLGEGASEAQVGPSVPPRPQKQSTTSPTELKKVPSIPDRPKPQIPARPAKKPDAAVPSDQEKASPPVVKAKPQVPARPGGVGSKIAGLRGNFMNDLNQKLGLGPPKEKEKVPQPEEDAKPLEDARKGRARGPQRRAPAKSAAAPTSKTFSFALSTPRSLWSIDEGDDLTVSSYDSSAQEATSVAGLSDEKAEQVDHSTPADAPLPSTIETTDQQEAASKEAPAPQATALAVNTAGELADPALKSGGDEKSTPSSIQVSGEGEGENGDLSKEITASSGQDSGPELEKEQAEPNTDDVSVSRQTTVSAKDVGLPLEKVPSHEGEDPRATKLPEGEPGQASAEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVP9</accession>
    <name>A0A0D2AVP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231029.1">
        <property type="nucleotide sequence ID" value="XM_016384427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVP9"/>
    <dbReference type="STRING" id="91928.A0A0D2AVP9"/>
    <dbReference type="GeneID" id="27337195"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10112"/>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="61585" checksum="DB0D7C291D47421B" modified="2015-04-29" version="1">MLQFPDFTSTYRFWALSSSSVSILLVRFSPSWSISHSYLWTFVCIFLLHELVWSTYSIFIYPHLVSPLRHVPTVPGGSFFAGQWSVLVKEPSGVPPRRWANEIPNDGLLRYFHLFNRERLLLTSPQALSEVLTTKSYDFVKPTLLFTGLAQILGIGILLAEGDDHKAQRKSLMPAFHFRHIKELYPIFWSKSREMVQCIQAELDKEESTNPNPRVVEVSEWSSRATLDIIGTAGMGQDFRALQDPDNELNRVYRSVFQPDRTARILSVLQFFLPRILIQNLPLARNRSVQAASSVARSTCRRLVEQKKARMANKEPMEPDIISVALESGGFTDEKLVDNMMTFLAAGHETTASAFTWAVYSLSQNPDVQKRLRAEIHAHIPSVDAANITYDVIDNMPYLHAVCQETLRLWAPVPLTLRSTAVNTSILGQFVPKHTTIIIAPWVVNHNVTLWGDDADKFNPDRWMAAGQANAGGAVSNYAFLTFLHGPRSCIGMKFAVAEFACLLAAFVGTWEFQMLDPDEEIQIKGGITARPRNGMRVVVKDAGWAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVS2</accession>
    <name>A0A0D2AVS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET9</fullName>
            <ecNumber evidence="12">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone-lysine N-methyltransferase set9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">SET domain protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_10142</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.372" evidence="12"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231059.1">
        <property type="nucleotide sequence ID" value="XM_016384457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVS2"/>
    <dbReference type="STRING" id="91928.A0A0D2AVS2"/>
    <dbReference type="GeneID" id="27337225"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10142"/>
    <dbReference type="HOGENOM" id="CLU_013724_0_0_1"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025783">
        <property type="entry name" value="Set9_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51567">
        <property type="entry name" value="SAM_MT43_SUVAR420_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="117"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="262"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="721"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW10843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="767" mass="84713" checksum="0E31D58C110A3875" modified="2015-04-29" version="1">MGRRRPQESEKTQRLSLTELAAHDDVCSDALIDNAYYKAKIRKNRTKHIPIRGIKEDEVPRILLHKVIVEKDIVAAEKALLALPGLKRYKKSLRTKSEQEHFLSHLRKYIAMYQTDCPWEVSTTNRYTITTYEAAVTARRRIRQGDTVKYLTGTLVPLTTEESADLDMTNRNFSIVVSARKKNTCIFLGPARFANHDCNANGRLVTRGDDGMEVVAVKNIDVGDEITVSYGDDYFGPGNIDCLCHSCEELERNGWTSKTAFLSSDSQTSTPGPEPQPSPQTRALKRKRGSELSSYSSSAPPPSKHLKATQSPSKLQHSWTPPGSALSDSELETGAREIGDTTEQQTSPSPPKQSTLSPPPSPAQLADLDMLEAPTVPEEPPRKSEPQLPSPKSMAKKGPRESKMTARLLGKLSARAPISPAPTSPSSHGSTSDSTTLNQATPSVSYTLAPVTIKVESVETTKVEADEDTIVVVTTRPTPAMSSEQSMSADEQQAEATIPLEPDQTPIPHVVSTLTTTTVTKDVQVLDEANSRNPEASVLPSIEPVSNSTTVATLSVHPVTGTIRIAGDYILTRKLLAQPHDRWVQCHNSLCFGFFIQPNGYQTRRECPRCERHSMLYGFPWPKTDPDARKLLERTGRGKKDAVEYSAYRRKGRCGKGTWVEGGGDEEERVMDHRTIHRFVLPEEEREITRKGLLKEAEEARAAGDHVLALLEAKMRAASRGMGTESAARGSESDNGSATPDENRRRSNRFVTRPVAVYTDRYSHRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVW2</accession>
    <name>A0A0D2AVW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cAMP-independent regulatory protein pac2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231089.1">
        <property type="nucleotide sequence ID" value="XM_016384487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVW2"/>
    <dbReference type="STRING" id="91928.A0A0D2AVW2"/>
    <dbReference type="GeneID" id="27337255"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10172"/>
    <dbReference type="HOGENOM" id="CLU_027883_0_0_1"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="50587" checksum="5F899A79D3C18ACE" modified="2015-04-29" version="1">METYNGHVRTPTDAIILFEACRLGILPRVQRRLSEKERQSIRSGSVFVWDEREAGMRRWTDGKSWSASRVSGSFLTYREMEGKRGSNSFVTPANKGAKTPDSNPDDLQNGEAEEGPDGYRYKPDGLMKQSFSITTSQGQHLHLISYYSRSHPTAQVLRQPSTDPNLAHVQPAKGLYPESTINDQSSVPAVTRSPMVGVPSYVVSTSAPGYQRPSPGNPHPYLPPGYLPHGAYIYPISPIHTPPGHYALQPYGLAHGLPAGLPPPIHYPPPGPGAYSPHAYPVSHPPPSAYDQRPLRTSESAPPPATTTTAATAAPAPPMIYSTSQSLPPPTAPLRSPGLPPPSPREEGEKAQIDPRLTTVAEAAESQPNSSTQKPDEQPPLRPAESAHTSASQAPTIHALVHSISTLPPPPPSAPPAEKPQHEAEVDRQGSTSPGGTKNGAPPQDIPSEKLGFREDKRALSKLDRVFARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AW06</accession>
    <name>A0A0D2AW06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_10212</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231129.1">
        <property type="nucleotide sequence ID" value="XM_016384527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AW06"/>
    <dbReference type="STRING" id="91928.A0A0D2AW06"/>
    <dbReference type="GeneID" id="27337295"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10212"/>
    <dbReference type="HOGENOM" id="CLU_016733_0_1_1"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="73"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="147"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="179"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW10913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="468" mass="50952" checksum="5DF776E3CF7DE98B" modified="2015-04-29" version="1">MASLRLRRTPALGSGLAMPKVNRSLQTRCFSALKTQSTYAQPRLYSPRPIALPTNASLSRYQRFSTSPAQYEEVIIKVPQMAESISEGTLSTFSKQVGDSVELDEEVASIETDKIDVSVNAPSAGKITELLVNEGDTVTVGQEIAKMETGAGGDSGPKEAKEEPKEPASKDQPTSSQPEEPKEKEPKKEEASPPPKTEEKPAPPKEEKKPAPPKDAKKTEEPKGVDSPFGKGSRNENRVKMNRMRLRIAERLKQSQNTAASLTTFNEVDMSNIMEFRKKYKDEVLKSTGVKLGFMSAFSKASILAMKDIPTVNASIEGPGGGDTIVYRDYVDISVAVATPKGLVTPVVRNAESLEMIGIENAIAELGKKARDGKLSIEDMAGGTFTISNGGVFGSMMGTPIINLPQTAVLGLHAIKERPVVVNGKIEIRPMMYLALTYDHRLLDGREAVTFLVKVKEYIEDPRKMLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXH8</accession>
    <name>A0A0D2AXH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231629.1">
        <property type="nucleotide sequence ID" value="XM_016385027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXH8"/>
    <dbReference type="STRING" id="91928.A0A0D2AXH8"/>
    <dbReference type="GeneID" id="27337796"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10713"/>
    <dbReference type="HOGENOM" id="CLU_549855_0_0_1"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="55003" checksum="4E2831F18CC926AB" modified="2015-04-29" version="1">MAEVQNNAWPDDSFWQEDGYQHEQLPIYSYPARDVRTSSAAAPPYQYGGGVSGFASSQSFSNTPRYISDHTPAQRPRLQGYENEQLYTMASTHHTYRERSSSGTSCNYSQARSATNSPAFAHYQLATGTHNVATFLSQGGSFGNSLAPHNGSAFSAIEYKEEEPHQNKDRAQRTEDGGSVNKTDNPKERLPCPHVECRGDDGKPKRFFSRKADVNRHIKSQHDVTRQDCPWPKCTRKGTQGFARLDHLTEHRRGYHSEDIPKRNSGNNSERQDETTPMSNAESGAVAQPSAGSVSVQASTSVSSSYHSTPTTSMAELSDGILIQPETYYTEKDNAIGSRKAVRKHKASHDRLDVDEDPTGAPAASADSSKRRKRARRPASAQMMESMSSWELELLSAEAERRPYYQAPPPPPPQNTYPRQEYRLFMQGPDESMMCRPQIHAQAQTRDHGQAENSTTSASLYLPSHCDIQAYTAAPQMQQYFRGRSQSMQSRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYT5</accession>
    <name>A0A0D2AYT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10881</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231796.1">
        <property type="nucleotide sequence ID" value="XM_016385194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYT5"/>
    <dbReference type="STRING" id="91928.A0A0D2AYT5"/>
    <dbReference type="GeneID" id="27337964"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10881"/>
    <dbReference type="HOGENOM" id="CLU_147114_2_0_1"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW11580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="127" mass="13625" checksum="ECA258F774D1B026" modified="2015-04-29" version="1">MALAAYRLATTHNVKSPGDQLTETRHLLRATRIAFDGDFHLLHAARTQARAGFDSLSSLDPGSQEALKGIEHAEGVASVLRHNIVQGQKIEGTDAIKLNLHKDIERGDNDTVKNPLGKGGKVKVGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B043</accession>
    <name>A0A0D2B043_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232261.1">
        <property type="nucleotide sequence ID" value="XM_016383638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B043"/>
    <dbReference type="STRING" id="91928.A0A0D2B043"/>
    <dbReference type="GeneID" id="27336402"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09319"/>
    <dbReference type="HOGENOM" id="CLU_010595_0_2_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35263" checksum="5C5ECFA3CAF343B2" modified="2015-04-29" version="1">MAAADGDSAYGESLFTETTSLHESVFNYQYENGRRYHSYNAGKYFAPNDEQEQDRLDLLHHVVSMILGGELWTIPIGERANAPVPESILDIGTGTGLWAIEIADKFPQAQVIATDLSPIQPTWVPPNVQFQVDDCESDWNFDQQFDWIRIANMGGSIADWPRLFRQCMAFLKPGGWIEVLDFEAWGSTDDDTLPVNSSYNRWQHELNNASYRTGRIMNVAPLIKDMVLNAGFEGVHEDIYKCPLSPWPRDQRLKELAMYMNLNLSEAAPAYSLALFTRVLGWEKEEVEVLMAGVRNDLRNTRYHLYTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B193</accession>
    <name>A0A0D2B193_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232904.1">
        <property type="nucleotide sequence ID" value="XM_016384281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B193"/>
    <dbReference type="STRING" id="91928.A0A0D2B193"/>
    <dbReference type="GeneID" id="27337049"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09966"/>
    <dbReference type="HOGENOM" id="CLU_017006_2_0_1"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="365"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="625" mass="69402" checksum="D5B5ED53CECFBDD5" modified="2015-04-29" version="1">METFSPRPWHEGELFFQRRIVDRGRSDPTTPFLAARYANWIQQYPALAMGTLDDNGNPWCTVWGTNLVPFVKPVAQSVLGVQATVDASFDPVVQAICRNNFDMKNNNCGTADKEMEMGGVSIHLEERARVKLAGQITAATLKRLSANRDVLVGGRSEGAAGELHLIVRIDQSLGNCPKYLNKKHIVAHIPRPKLLSTSPHLPQKAIEVVHNADAFFIASSHKHRDMDCNYRGGPPGFIRIVQPDDSEEASTIVWPEYSGNALYQTLGNLRVTPQAGLVIPNFETGDVLYVTGNTKVLLGTEASNVIAKSTVAVALMVTDAKLVENGLPFRAKVVEDGAQGRSPYNPRVRYLTSEEIGKFDQVESRFCATARMIKKTRLTPTITKYNFTLVGHKSVFGSWKPGQYVTMDASASMTKGYSHMRDDDPTSLNDDFIRTFTITSLPSAVGEETEDFEVMIRSIGSVTKWLEHQKDGICEVAVRGIGGDFTFASSACNAFIAAGIGITPLLSHLDHIHFNTLRTFWSVRMVDIGLPLAILRDYPALIRSTTIYLTGFEALPNKDGGKGNEEIQRLIDTGVLVQQRRLCKEDLQPCLPQIENWYVCTAPTMRRQVHEWLPGTVIHYENFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1D7</accession>
    <name>A0A0D2B1D7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_07929</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232959.1">
        <property type="nucleotide sequence ID" value="XM_016382256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1D7"/>
    <dbReference type="STRING" id="91928.A0A0D2B1D7"/>
    <dbReference type="GeneID" id="27335012"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07929"/>
    <dbReference type="HOGENOM" id="CLU_026207_2_0_1"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="157"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW12743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="433" mass="47570" checksum="65EBB65D09951D73" modified="2015-04-29" version="1">MAPKSWLDIPRGSHFSLANIPFGVVTTPKCSDRHAAIAVGDHVLDLHEFAQHQGFSGLEDSTASLIASFSKPVLNDFAALGQEVHTNVRRYLQEILKYDTRFPSLLKSNVGAKESCLFHKDQVKMHLPMKIAGFSDFFAGKHHAYKCGRILRDPSKALSANYFHLPIAYHSRASSVIVSGTDIRRPLGQFLQNPSDKEPSFGPCSQLDIEVELGALICRGNSLGEAIDVNKADEYIFGFVCLNDWGARDFYSWEAVPLGAFNSKSFATTISAWVILKDALEPFRVKGIENDTKLHPYLQQRTVENVYDMKLETSIRASNGDSGILSRTNGRYLVFSFEQMIAHHTVSGCPLEVGDLIASGTLAGPEPGSFGCFLEGSNGGKQGIDISATMRRTYLEDGDSINIRGWCGEDDLSLVGFGDCEGTILPPIRPAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1S6</accession>
    <name>A0A0D2B1S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_09837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232776.1">
        <property type="nucleotide sequence ID" value="XM_016384153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1S6"/>
    <dbReference type="STRING" id="91928.A0A0D2B1S6"/>
    <dbReference type="GeneID" id="27336920"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09837"/>
    <dbReference type="HOGENOM" id="CLU_009030_2_0_1"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW12560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="735" mass="82092" checksum="296E214808F5330E" modified="2015-04-29" version="1">MPPARQPKVRSRTFTSCLECRRRKVKCDLSEPSCNNCLRLGLTCPGFSIQLHWLPKWQSGAYDKAKGAAGGDEIRRARTDIFGTRSGLQFSEDLIQQLSESSRSAQVDEALETLETRVRESAVGLDRQQHWQMFEGPFSVFCPPLSMETLAVKRPKLATPRLPNNDSSATLWLSNDDWFSAVPDEVFPNDALTADLLDFDLGDALSSIEKSSSLDFEHAFQSGSYGDRSSEDKPQYIENAVDKFFASNAPGALSSFYGHPSATSLPNGSPYLPHNVRFLLSHYTSHVIDSLSLLPTNQAPYRGIHMPYALTAYGELDIMGQSGFARVSLLYSLLSLTCYHLSSLYEPSSGGHRPEGSHPNPSNSRYWSSQGLKFRDIARTSFRKCLQAMVSDPSFKVKYKELFVGAMSLICTGIISGDPWDARFFILQCEDIVNRIGRTKRRFSDKALQLHRIFSYIRIIEQTTFVQTRDQYLDTLDKHALFPEHVEMVKQIPHDTFSHSATVARNLQTMSDLGLTGPEEETFYELYGIPGSLMRLIARTNNLIADIDPPELHGTSPPAMPPSVVEAAAALENDICRFQLPKTGDAASSGRGTDLATTVNPSEIVRSHIGTAIHHALLVYFFRFVRGTNPIILQHYVESILSNLESHQASKHRFFVGARLGTTVWPSFIAACEALGDDLRHRAVVCMRHATWAGFKNAEAAEVVAREVWRRRDAGENDVSWSTVLRESRTILLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B373</accession>
    <name>A0A0D2B373_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233584.1">
        <property type="nucleotide sequence ID" value="XM_016382881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B373"/>
    <dbReference type="GeneID" id="27335639"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08556"/>
    <dbReference type="HOGENOM" id="CLU_078844_1_0_1"/>
    <dbReference type="OrthoDB" id="5363135at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="151" mass="16645" checksum="B29EB72811B6C9DE" modified="2015-04-29" version="1">MSADTSDLTKVDSAIGGMASSPPKETKRRHTSSAPGVMNLNDLEKEGVKITIAPETQKTGWKLNTSTSSVEDPSILKKMLTEPPVKKIDLHFPLGLEVTARNLKGADDELEEPYLKGFEWDPEESWTRLKVHTQKEGLPTTKKSKKKGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3M9</accession>
    <name>A0A0D2B3M9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mur ligase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233496.1">
        <property type="nucleotide sequence ID" value="XM_016382793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3M9"/>
    <dbReference type="STRING" id="91928.A0A0D2B3M9"/>
    <dbReference type="GeneID" id="27335551"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08468"/>
    <dbReference type="HOGENOM" id="CLU_015869_2_0_1"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur ligase C-terminal" evidence="7">
        <location>
            <begin position="339"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW13280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="489" mass="52894" checksum="C73889D636326BDA" modified="2015-04-29" version="1">MINLGLQRITALLQPLFATHPASLPWKAIHIAGTNGKGSIAALVSAFLTRSGYSVGRFTSPHLVDRWDCITLNQRVVDRDRFLAVESEMRVRSQAQHIGASDFEILTATAFELFTRSAVDVAVVECGLGGRLDATNVLRTQDVLVSVLAKVGLDHTEFLGDTIQKITWEKAGIFKPGVPVVVDESNDAEVLDVVRRKLDELGDGDAPGVHYVLEGAQEELLARSIEKMRRDHGGGNLAAEHQEQNLTTAWTAYTLAERQLEQLKSKSALSGPTAINGDCNGGDGGHWMQNVTETAEELPRLVTAAQKSLRGRLEWLEIPDHIIIPEGSQKKPTTTMLSKRPCRVLLDGAHNPQSAQALAAYVDQSVRQQEQEQRTASKRKVTWVLAAKSDKDVGAILSILLRPGDNVVTCSFGPVDGMPWVKSMDASALLEMARAFVSDESTTTMEAAPDGSVGDAIVRALEIAGGQDPVCVAGSLYLVGDVLRLIRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5E7</accession>
    <name>A0A0D2B5E7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234339.1">
        <property type="nucleotide sequence ID" value="XM_016381237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5E7"/>
    <dbReference type="GeneID" id="27333987"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06904"/>
    <dbReference type="HOGENOM" id="CLU_164887_0_0_1"/>
    <dbReference type="OrthoDB" id="10372476at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="2">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="94" mass="10751" checksum="431CBBCBCD92EF42" modified="2015-04-29" version="1">MANNRRTNTDPANTRLNFRYTQKNCPGHEYVGKLNEGGMTPMEWTCHHCACRTKKAWECQNCGFLICNPCSIYSTQVTGKLAKDQPKYIGRKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6P0</accession>
    <name>A0A0D2B6P0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234744.1">
        <property type="nucleotide sequence ID" value="XM_016381642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6P0"/>
    <dbReference type="STRING" id="91928.A0A0D2B6P0"/>
    <dbReference type="GeneID" id="27334395"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07312"/>
    <dbReference type="HOGENOM" id="CLU_040908_4_1_1"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF10">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238867" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="267"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="498" mass="49639" checksum="DEE259680CA37422" modified="2015-04-29" version="1">MVSQIFPLVVLATTVLAHPQRHHHGHFHGTGTGGAAAPTGGAFPLNNTIWTNSTGLNGSAIESPTAATAVLTVTVSPLPLESSTGNDSTAFSSVPVANAAATSPAAIAPVLSSSSSCTSILISTITSTTVELVTVTATPDASPVTDDSGKSVAAPSSSSAPLGDTELETGLDATSGSISFAAGTATAGAFFGRPSDGGWGSSYSAPEASAPAASSSSAVFSAAPTTFATIPSPAASSSAASGTYSSASSASSSTPSTGGGSSGGKKGLSYNTASLTDAFAGKGISWVYNWGASPDGTPLSGTEYVPMFWGSQSVSGWSSAVQSAISSGSKHVLSLNEPDLDTQANLDPETAAQLHIANVAPLSGQVSIGSPAITNGAGTSPLMGIDWLNQFFKACAGKCNIDFVAFHWYGEASNFADLQRHTQAVIDAASSNGVSKVWLTEFGTTTGSDSDVASFLSQAVEYLDGQSAVERYAFFMCSDGLLVNGNSISSPIGSAYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6W5</accession>
    <name>A0A0D2B6W5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234874.1">
        <property type="nucleotide sequence ID" value="XM_016381772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6W5"/>
    <dbReference type="STRING" id="91928.A0A0D2B6W5"/>
    <dbReference type="GeneID" id="27334525"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07442"/>
    <dbReference type="HOGENOM" id="CLU_075342_0_0_1"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35730" checksum="43EE289EB1C3F618" modified="2015-04-29" version="1">MSIATQSASHCINSDENVSIVALLAADSEANKVSKKREYNRNAQRAFRQRRKEHLRNLEAAQAVSNSIQVENVKRLRRDFQLLSQENESLKAAYRSPAYRSPATSHISTISPSPSKDIHYGALYPDYLGSIPTNASYTPEFGPSTLYPLTTTLASSVSTIPANSVLMSPHNIHDIRRNLYTMFSPLLEISVPSTSQMHLATLAALKSTLPNPLKPTSLQLSVPHDVYIDLIPSPSLRDRLIMVGPANASSFLTDACTIACDIEDTGQIIVWGKDWLNEFSWEFCPSLLERWGGFILGPEWGQRANFWRKQRRAPIIPSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B829</accession>
    <name>A0A0D2B829_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235229.1">
        <property type="nucleotide sequence ID" value="XM_016382127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B829"/>
    <dbReference type="STRING" id="91928.A0A0D2B829"/>
    <dbReference type="GeneID" id="27334883"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07800"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="37"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="128"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="353" mass="37439" checksum="4E76A33FF94DAD40" modified="2015-04-29" version="1">MSSGSAKVKVAILDDYAGIAPEHFRDLSSRLEVQSFPETLNAGVAAEHEALVQRLRPFTVVSSMRERTRFPRSVLAALPNLKLLLTTGGRNAAIDMAACAELGITVVGTGAKPTAVKGYDATNEMTWALILGAAKDVVGGDAVVKSSPTAWQTTLVAGLAGKTLGLLGLGKLGTQAAATGALGFGMKVLAWSSSLTQDKADDAARSRGLPAGAFEVAASKQDLFERADVLSVHYVLSDRSRGIVGADELGRMKKTAVLVNTSRGPLVDEAALVDALEGGLIRAAGLDVFDTEPLPRDSPWRRSGYWGTDGRSRLLISPHMGYVEEETMHGWYEQQKEALKSWLEGGEIKGIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9A7</accession>
    <name>A0A0D2B9A7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235704.1">
        <property type="nucleotide sequence ID" value="XM_016379877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9A7"/>
    <dbReference type="STRING" id="91928.A0A0D2B9A7"/>
    <dbReference type="GeneID" id="27332617"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05534"/>
    <dbReference type="HOGENOM" id="CLU_008468_1_0_1"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="412" mass="43266" checksum="866CFEFAA1D1D6D6" modified="2015-04-29" version="1">MANGMMQMGGAGSPMMQGMNPPPFNENMPMELYNQRMSQGQMQGTPGGGQSGNHALQDYQMQLMLLEQQNKKRLMMARQEQDNAVNRDGAPMVGMQAGGMSPSGSRTGTSPNPGDQMKRGTPQLGGLPPSPSAGDAMAGRSPAGMNFMNGMPGGDFNPAMYLKDNQGMVGPGGPNIRPPTSMDMQQAMARQQQQARLSGQFQGGQPMVQQPSQGQPAPMGTPGQRNEMPPPQAPAANSSQRNQPGSPQSSNAPPTPSTTNKPNPKSKKAKDDSNKKKPAKKNSTANAASSENEPPATPTPSTPITPVHPQGFGGQANKSGGGGGMANANQPPATSHPMPPAQAPMHQPDLQPSFTDNFGPDQNFNLDFSTLENTDVLENFDFDSFLNTTNDDTFNFDGAIGVGGDFGLEPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BB85</accession>
    <name>A0A0D2BB85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236494.1">
        <property type="nucleotide sequence ID" value="XM_016380667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BB85"/>
    <dbReference type="STRING" id="91928.A0A0D2BB85"/>
    <dbReference type="GeneID" id="27333412"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06329"/>
    <dbReference type="HOGENOM" id="CLU_015161_0_0_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="685" mass="77812" checksum="A37984CA952F3FF6" modified="2015-04-29" version="1">MRRFVIFPDNISALTVLAQPALDLHILMEDRREAKRARQACLNCRRKKSRCSGEKPVCAFCARLGQRCTWDGHEDRSPESFTESRGTSATAAVHHDSDLAARIALLESRLNFLDAENAFRLFSSLPGPGNPAEQEVAQQSYDQQNVLTDQVEDLRIDFLSLPYPELLRSLVDVYFERCHNQPYAYFHQESFRYDYDSGVLPDYLLYALAATACRFSDHDFYRNKWSDAIDSYAQASFTQILERYFSDADSLQVDMIVALSMLATVEFAAGRPKLGWIKLALSTRFAQSLRLNEEPDPQLPLLEQEERRRVFWSVYLLDVLMSVGPNRPPSLLDEDCTVRLPCDENFFNEGTAFNKRIPVNSMPTLTEVQEDASIDLPPLNSFALTILMASALGRFLRFSLKRTLNKARVLWDPRSKYYEVHSILLRYESQSPCAFTPVIEVIHKLPTLGPQPPSKVSHTVFAHVLYHLNQSLLNHPFILYRFFHNYAAPIPLSFVQEALQRCHQHATSLIELLTNLETHCPLSHASFYGYCVMAEGLILRMYERNNDKNIADAASRRVREALNFLQRKPIRWSHVGHMGTLLSSFELDASIARVLTDPASLARKVDVPHGTMLWQLLDYAWAPQNKPPSAIRSSLAIADLLSETAPEEANNPTGSSCDSAYTPIVLFDSRDSLPSSYARMLGEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBL4</accession>
    <name>A0A0D2BBL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236619.1">
        <property type="nucleotide sequence ID" value="XM_016380792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBL4"/>
    <dbReference type="GeneID" id="27333538"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06455"/>
    <dbReference type="HOGENOM" id="CLU_1372236_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="199" mass="22167" checksum="0CC8D59B4C9E5386" modified="2015-04-29" version="1">MWPTNLNLHLDLNRYPGQTHGAPSYTVMQYVDQFNPFAIQNLPRDIIAAGSAEARRSPVLMGSLALLVAICGVVISLLSLHVVIIPIYRYMVRRRFSYDSDEDAERALQQARVEGPFKFNGLQYCGYVEPVPVPRPATRSSQYGSISKHTPEPDQDKQSTKACEVIRPAASADSSYSTIIEYSPEDCTCGLCLQCQRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BC58</accession>
    <name>A0A0D2BC58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_06261</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236426.1">
        <property type="nucleotide sequence ID" value="XM_016380599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BC58"/>
    <dbReference type="STRING" id="91928.A0A0D2BC58"/>
    <dbReference type="GeneID" id="27333344"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06261"/>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF87">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239027" description="laccase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="100"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="227"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="447"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW16210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="609" mass="67908" checksum="7E75B7345AB521A3" modified="2015-04-29" version="1">MAPTKSLAMFLFLSLSSLLFCRSFAAFIPTAELVQLPRDLVQRQVSTSSSSSATSTKKADPQCTNGPFTRQCWGNGFSIATNYDSTWPNTHHTEYYDLEITNTTMAPDGVPRVVYSINNQFPGPTIRAKWGDTLQIRVKNSLTTNGTSIHWHGVRQWYSNHMDGTNGVTECPLAPGQTRTYTFLCTQFGTTWFHSHYSDQYSDGVVGTIIIDGPTTSNYDIDLGTYPITDWYYRPAFEIAPLVQHAVIRGPPPGDNILINGTNVKVNGTVGKYSRTTLTKGKKYKLRLINTSTNDNFKVGLDEHNFTVVTADFVPIKPFVTKWLFLAIGQRYDVIIEANQPVDSYWFHVVPQTGCSNNLNKNALAIFTYAGATSATPSNATRSNAPAGAPDCSDPNKSLVPYVKLDVPDNYTIPQSSHLEVGFAIVQDAAQQTQVQWNLDFNAINVPWGDPTLQYVLDNNTNFPTSMNLISLPNANTWSYWVIQALQTQAPPQPHPIHLHGHDFYVLGADSGVYNNSQTLNYKNPPRRDVALLPANGYLVLAFITDNPGAWLMHCHIAFHVSLGFGAQFLEQPDYIRSKLGIKQEWHDECKSWNKYYATAQYLQEDSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCB1</accession>
    <name>A0A0D2BCB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236824.1">
        <property type="nucleotide sequence ID" value="XM_016378147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCB1"/>
    <dbReference type="STRING" id="91928.A0A0D2BCB1"/>
    <dbReference type="GeneID" id="27330879"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03796"/>
    <dbReference type="HOGENOM" id="CLU_035438_0_1_1"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="66"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="174"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="386" mass="42801" checksum="D888CAF29AEF8E2D" modified="2015-04-29" version="1">MGKVKRQAQKHSNHHDNPRKGATSISRRQHSQKPPTIVKKAASKPVSHDNLQGRLKVPFTKFDNVLLVGEGDFSFSLSLKQHHKVNQITATCYDSKEALESKYPSVAQTVRRLAGSSHEFPTKEIPGDDSDSTKADVHVGGEDTEWNGFSPPPLSPSPASPGDEAGETTSKIPKVNLLYGVDATKLLSTHKKALRPYGPFTKIVFNFPHVGGLSTDVNRQVRYNQELLVGFLKGAKDLLSTPARPAKVIKSETYDEDDELDEAEVSDNETRRDPGAVSGQILVTLFEGEPYTLWNIRDLARHSGLKVIESFKFPWSAYPGYQHARTIGDITTGKDRSEQGKRKGAWRGEERDARCYVLEDKDAETSGQASKKRKRRDHDSDGDDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCG0</accession>
    <name>A0A0D2BCG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236531.1">
        <property type="nucleotide sequence ID" value="XM_016380704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCG0"/>
    <dbReference type="STRING" id="91928.A0A0D2BCG0"/>
    <dbReference type="GeneID" id="27333449"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06366"/>
    <dbReference type="HOGENOM" id="CLU_063954_1_0_1"/>
    <dbReference type="OrthoDB" id="5358398at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Luciferase" evidence="2">
        <location>
            <begin position="181"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="292" mass="32747" checksum="EB6CB133BB0C52A4" modified="2015-04-29" version="1">MDNDMYILPNATEPQVIPSSLPLHPIVVVVGLAISLASFVSWCVQDYRLYKSLGPGGPPYNVYGWFLTSFVVRPYTLAAHDTTWTGDYPDNAAHKEILALPNRKGSRPLILGIAPQRQFSQNPEPGMNARITSLFTSLVLRNPRSLQQSVSSLEKHNLALFVHPSLLSKSENLPEVATVSRGELGHMHGDASMHLYFSPADAKEIIEKGWAERHRCAREAPWWLGGRRNSWKIGHTFLIVYAPRNEEELEVLQVLLRASARFMTGDEMVVAPMKDDQETEHELERMRSAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDE2</accession>
    <name>A0A0D2BDE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_03818</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236846.1">
        <property type="nucleotide sequence ID" value="XM_016378169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDE2"/>
    <dbReference type="STRING" id="91928.A0A0D2BDE2"/>
    <dbReference type="GeneID" id="27330901"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03818"/>
    <dbReference type="HOGENOM" id="CLU_141397_1_0_1"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW16630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="94" mass="10635" checksum="48C741AE2A4DDEE5" modified="2015-04-29" version="1">MDDDINVSAEDLQHLSNAEKQQLQTFIQTESQRSSIQKTVHELTEMCFKKCITGSISSGKLASKEESCMSNCVNRFMDSNLAVLQHLEKLRAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDI9</accession>
    <name>A0A0D2BDI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236906.1">
        <property type="nucleotide sequence ID" value="XM_016378229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDI9"/>
    <dbReference type="STRING" id="91928.A0A0D2BDI9"/>
    <dbReference type="GeneID" id="27330961"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03878"/>
    <dbReference type="HOGENOM" id="CLU_012318_0_0_1"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="67849" checksum="DFEE1E4FF1D04493" modified="2015-04-29" version="1">MREITAVVYATTVEASQANGRANRRARLNRSQASIPKSQSSGSSTAVRDSTISDGPAIEPLVSLDVAEGDLLPWLDFDLDGIDQFDLSVTPSLPQAEGQFAQSGDVVPLASSQSHSQYRTRSVVGCALRSPTHLLNAKSNATILDDHLSQIYETITLGAGSVFLDYNCNMYTGRYRYELEENIPCSDAKYSASVLDFLNNGLPDLELHSKGPELASTPCRGTSLLQIQTPLTTFASQRLPLVSTTRRMRVMGAFRFLDHFSDLWGVPLSSADQKKSDEVLKAVLRAFSFQWLSSSDTKVAFGALFSTPAGRMQQEPGDFVDAWHNARSLINDSRSIYSFRVVYAALLFDTIDVPQEIRGSPDNNGFENEFLDSGLDKLLALEAPLRRYCTTLGPFSEYSGLLEASLNIALWFGYLRDTVASLLTRRSCRMLDIPRQRKFSLSQTDIFNVEGGIPDMCREALANATYVWRQIGRFQNEVSNSIDAIPSISSVFAAIEGYEATYHILLDFPLESIAHLPVGSTKFWSVYKFTVGLMFFWYLGVLVVTHTVQSVTANNESMDQQFGCKLRHYQLKAISALTRTVECVSTLPTPGSWKPDSGLSADIPITACHISPGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDS2</accession>
    <name>A0A0D2BDS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236981.1">
        <property type="nucleotide sequence ID" value="XM_016378304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDS2"/>
    <dbReference type="GeneID" id="27331038"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03955"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="63"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="509" mass="56303" checksum="B9F94E5FD2BE1BF9" modified="2015-04-29" version="1">MTIEQSPEVEAGAVAADSKDIKALDDDGVMVVSAGDEARRVSASIAIDPVAERRLVWKFDLRILPTLAVMYLFNSLDKSNLGNAKTAGLEKDLGLKGHEYNLVLSIFFIPYVLTAPFLGIAGKKFGPSRVLPIMMLCFGFVTLMVVAAKNFGGILALRWFLGMSESAFFPLVIYYQTTFYRRGELARRLAIFYAAQSIASAFGGLLSYGVFQIKSGSLANWRYLFIIEGSCSMLFAVFAFWYLPYNAQSAKFLTPEEKQLAFYRIQVDSSSVVGEKFNFRSAIGILKHPTSWIILAIEVCLGVPLQSVSLFLPVIVKRLGYSTVKTNLYTVAPNVSGACMLLILSFASDLTRLRFPFVALGFAFTCIGFIIYATVNVTSQLHVAYFACFMMTWGTSAPSVILDVWYNNNIADENKRMMLTSIGVPVANLMGVVSSNIFQNKDAPKYFPALITTAVFGACGCFLTLLLGAWMIVDNKRRDRRDGRTIKAVDIPSELLAEGPASAHYRWFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BG81</accession>
    <name>A0A0D2BG81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_11331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230585.1">
        <property type="nucleotide sequence ID" value="XM_016385641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BG81"/>
    <dbReference type="STRING" id="91928.A0A0D2BG81"/>
    <dbReference type="GeneID" id="27338414"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11331"/>
    <dbReference type="HOGENOM" id="CLU_000315_2_7_1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="247"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="631"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW10369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="800" mass="90578" checksum="7EAF268E50CC9CF1" modified="2015-04-29" version="1">MTICYGMLCDVHVEILVPLLPSVGYQGLLWDGARELQNPTDGTQLASLTPSTAQMLQTLSSKARTEFQFWLSSREHLADPERRGSERSSGMGGVSINGNLSVILYGPKNMADPVAEWLDGLKMYLQVPWACDRDVPYINPHCLASGQEAVVYTSKLPSDLVVEESEVRNGGEDPFFDLYNTSIFDLAPQPSAIASKLHAHQRQALTFMIERENGWNLSGTRKDIWKSYLTAFGDTRYKNTVSGLTQAHPPVNFQGGIIADEMGLGKTCTMLGLIAANPFQSDFYHQSSDCLKGTLIVVPFPLLFVWEKQIQEHFYPGKVRHAIFYGRDRQKETNLKDYEIVVTTYNTVALEWKNYKASRNSSDSNLLFSAFWHRIILDEAHVIRSKDTVCAKSVYALQADRRWCITGTPIQNRLADIFSLLRFLKVHPYDDLRTFEEQILRPWKSKTDENALKRLQLIMKAISIRRPRAVIALPDRSEHTEEVVFTDEERGVYDSARVGVMEVLENAIHVDQSTSGSIYLNAFQRINDLRYICNHGVTPPRRRNHTSSMDTFEEGPCPLPDDKLEAWIEGKDILCICCGAELLEEEEGDNDRFLSELHARRPAAAVTASIKSTGISSPTSSKMPMQQPSSKIKALISQIRQLPLDDKCVVFSYWTSSLDAVEAALNQAQVRFCRYDGRLSRPKRNQVLTEFTNDASLRVLLVSITCGGQGLDLTAANHAYLLEPQWNPMLEEQAMARVHRLGQEKAVRLVRFLMKDTFEENIVRLQRRKRTLADLIVDRTPLKAGTDGKKQLYYLRELVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BH27</accession>
    <name>A0A0D2BH27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238141.1">
        <property type="nucleotide sequence ID" value="XM_016379464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BH27"/>
    <dbReference type="STRING" id="91928.A0A0D2BH27"/>
    <dbReference type="GeneID" id="27332203"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05120"/>
    <dbReference type="HOGENOM" id="CLU_591879_0_0_1"/>
    <dbReference type="OrthoDB" id="4151057at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="51273" checksum="41B7A2B15412D7AA" modified="2015-04-29" version="1">MYIPVSNDPFNVIHVNPVSVERSSESWFDHHGLALGNGVKPESLEFPAAIGNLQQCKSSDLSMTAHASEVSDWQYLYKMPPTRARTPLHTFSVVRTISQDPTINRLMENYARNIANVLPALRHSDNPDSTIYFPKAINGASNVSPSLSSMRFSRLRHFKGAYSERESYFDVMARNLRAKAFASLRKALPASCQDRKSLPQHDQSASPYRESVLSAMLTLVTMDVMEGSMSEYWIHLGGIGKMAQHLSSGTKDSRINLQLVTIACFLSTLAKTTATDLPSLPWTGELGSTSNSRTSGYGTGYGLEFTYGITPVLVNYIERIVTLAQHFSYYATNDTPVVPPSLITSCLDLSNDLSDRSIESESLSNFFSGEDSETNLTLLLAKHHIIAFAHALRLYFHTRLLPWSPADMALCADRVASHLVEIEKLKAVAGYDFNSSATIAWPGFVTSCEAVNSTPRQVWRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIH7</accession>
    <name>A0A0D2BIH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238969.1">
        <property type="nucleotide sequence ID" value="XM_016377399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIH7"/>
    <dbReference type="STRING" id="91928.A0A0D2BIH7"/>
    <dbReference type="GeneID" id="27330125"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03042"/>
    <dbReference type="HOGENOM" id="CLU_022445_1_0_1"/>
    <dbReference type="OrthoDB" id="2307332at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050917">
        <property type="entry name" value="SOX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803:SF5">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="185"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="185"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="471" mass="52637" checksum="CF031BA1278F82F5" modified="2015-04-29" version="1">MGHNTRPPSPLHSADGRYHSGDNNRSHPVAAPVPEQFTPPMHGRPFMTEIMSQSPFDHYGDPSLYHTAQAPIYYTPPRAMITSMPAHTPPRTIPEDGIQTRNGRALGTPSSPGAITNSTRASESPLNRPRRNLKKKPSKKRGPVVEQPLSIMTKDYKTPVRDMSLWVNRPVEERLAEVERKKGYVSRPMNSFMLYRSAYADRAKQFCKENNHQVVSQVTGASWPLETKEVRDLYEQLAVTERDNHQSAHPNYKFAPNKAAKRSRPDDDSDSDGEWEGSNRSSKRGRQVPSRSASSTPFDERMPTYIHSVPTVNPSGYEYTNPYGPPPLMVGPYGLSGDYYQTTTAPYADQISDIKYQKMVDPFPQYQTTLGIIGMPNTAHHELLTSHPAPTAPSQIDMLDPRLGQGDSDFHFGYYEGDMTMGPDVARTITYEPAQAVTYPPEAYHPGMATLTAEDDFGAGSDFETEFRKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIS5</accession>
    <name>A0A0D2BIS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_03122</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239049.1">
        <property type="nucleotide sequence ID" value="XM_016377479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIS5"/>
    <dbReference type="STRING" id="91928.A0A0D2BIS5"/>
    <dbReference type="GeneID" id="27330205"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03122"/>
    <dbReference type="HOGENOM" id="CLU_016758_1_0_1"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="438"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW18833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="730" mass="81746" checksum="BF73FEF6F6042D7E" modified="2015-04-29" version="1">MDALALSGANVPQGKSTASDHGAEDTPSAQSDNKFQRAIAAWRNIDLSSLMPQLDSTASEIVSQQRDALLERKELAQKTKDFRKLEDAAKLTEYKALLKSYQSFIDLITGHGKTSSSAFLQLYQPLSEAPDPFPLLEASVDSLVASEETVPRLTTENQQLLARLNKLSTQLEETERKLQDESNARREAEAGSGSRVQEIEQKWEKVLEEKQNNWKSREQALEEKVENQDRLLKELKANYEVSQRLQDGTQESASSKATSAELEMVHSELEKTSARLAEVEARNEQLRLDLARASQNAAKHEIEEDPAFLRLQSENSALLRKIESARFEKEAEKRTWEDRLRQAERQRSQLSGENEDLRTKINKWSDYDDLKRELDTLRSLELSVGDDDNTDDAPTNGSADSGNKQSLEQLLLARNKKLSNELTLLRVSHQDLQRQVEEHQEELSRTNAELEKSQKLSSTLENDLLRIQEEAANALPSSGMSATGTYVSRHPASSLRRGRASPTSSIISGYEMQPRTTTLESLRAGEPVGGGSGILPMIQAQRDRFKQKNQQLEEELSKTYATVTSLRQEVASLQKDNLSLYEKSRYVSAYNRGPNAASSTSYGASPGHLSVHLPDDSTSNRWKSQYEAKLSPFAAFRGREATRAYNRMSLPERIIFSLTRIVLATRTSRNLFAAYCMALHLLVFLMLYWMGSADVDRTAVHLGEAAVAAGGAALHAPDPNTAEWRQEEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJV2</accession>
    <name>A0A0D2BJV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_03492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239414.1">
        <property type="nucleotide sequence ID" value="XM_016377844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJV2"/>
    <dbReference type="STRING" id="91928.A0A0D2BJV2"/>
    <dbReference type="GeneID" id="27330575"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03492"/>
    <dbReference type="HOGENOM" id="CLU_003954_1_1_1"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000397">
        <property type="entry name" value="Serine/threonine-protein kinase KIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="278"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="219"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="595"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1029"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="736"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="815"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="962"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="992"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1029"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1068"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1091"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW19198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1106" mass="122548" checksum="6AF9DDE58E2485A4" modified="2015-04-29" version="1">MQATGQYREHVPTSAAYIPSGNLRYEEQEVDDEEEESVDPEGYYTNQSYYSSRQMEEPVRYTSHQEQNPVPATYTNLPYHIRNQSAAPDQYDGPPIPPPRTSSQQQSSGSQAVPGRHARSNNNPDISSSRVQNRVGDYNEEPRDRPREDTATAAASAARNRRKHPSSPEGPQQASSTRERSHHTAPSSSRSDAIMQSSNPQAPLVREYSEIIHRVVVSDPQEDEERAQERVAEAQPAPIGADSANTAADGEDLLPAPGPARRQDYSKSRRKEIQFGDYVLGQTLGEGEFGKVKLGWKRDGSSQVAIKLIRRESVASNPSRLPKIYREITILRDLAHPNIVRLHEMVETERHIGIILEYASGGELFDYILNHRYLKDPAARRLFAQLVSGVGYLHKKGIVHRDLKLENLLLDQNRNIIITDFGFANTFDPTDELSDEIVYNLSNKDFVRKFKLDRLDQRGMRRGDLMQTSCGSPCYAAPELVVSDSLYTGKKVDVWSCGVILYAMLAGYLPFDDDPSNPEGDNINLLYKYITTTPLTFPEYVTPHARDLLRRILVPDPRKRADLFEVARHSWLSEYHHVVSHITSSTTNVADIAHTTVPSEEEPSTMHRSASVREGPSKPSATSPGALARTPEGLLPEVEDGSTGSRRDRSARHTLQPEYVPPQTHTARRQPSESTSAAAGRGGVDKSQQTPNATLSQSLSKPLPQEPAMDIGQRKPQSAEKMPPPVRPGRDIPRSVSDSTTAFGQSAPTSGHQYVARPSTQGSMTSAGVPRSDVRLPSRGSYGQPVAPTVAATNVEGRVTQPTKPSRGYNISGPIPQSTTYPSIGQPTATPMPPQAVQQVQKTHHRRSSTLSGLGERLFGRSNSVVRKDAERQKIARKYPPTSMREYPAEPQPRASTDSKRSFSAFGLGRKRSTDLENQGQTEKPVRRFSLLSTISFKGLMGGSKDETSSKPGTPPAERFAPSTSSRPPTGQQYASGAVNPTDGQYDMSRGAQYSNYSRLPQQQRGASTDVYGGTGVYSPYEQGRVVHQRQQSEPMAHMMSQQAEPAESRPSMQQGRQRSVLVKNNRKFTDAYAHDHGPNHHGGRSGAVKRVQDFFRRRRGTEEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKB7</accession>
    <name>A0A0D2BKB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239574.1">
        <property type="nucleotide sequence ID" value="XM_016378004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKB7"/>
    <dbReference type="STRING" id="91928.A0A0D2BKB7"/>
    <dbReference type="GeneID" id="27330736"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03653"/>
    <dbReference type="HOGENOM" id="CLU_004083_7_2_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="762" mass="86382" checksum="0909B4EF7492B8D8" modified="2015-04-29" version="1">MESSVPDEPASRSTQDVPIVDDSKRPPVPRLNPRSCITCRRRKVRCNKQDPCANCVRAGIECIFPAPGRAPRKSRKPPDAELLARLKRLEGVVNSLGAQVDEHGIVSPTVAGTADIRARSFADTRVADSPSSERSDSKRQSIDKSLGRLVINEDRSRYVSNTFWTGMSEEIAEMQDLLDLSTTDEEDESNSPVQDRQTGSHQGFLFGYSSIKLDLRELHPSPSQIFILWEVFKENVDPVVRMLHRPTARTILMNAASSLDRVSRPAEALLFSIYYGAVVSMTHEQCRQLLDEDKELLLKRYRFATEQALARADFLNSSSLMCLQAFAFFLVFVRHVDESRSVWALGGLAIHLAQSLGIHRDGTNFGLSPFDTEMRRRLWWHLSLMDNRAAEDHGTDPTFSEQFYDTKLPMNYNDDDIYPGMKEYPPERQTATEMTFCLIRSELSILPRRLNFTAPGAMPGQTQEMTLEQKEKMIDECHRHLEEKYLHYCDPNVPIHWVAATVARLILAKMWLSIHHPRSFGSPTGDALLPQEVRDRVFITSVEVLEFTHLLEQNEKTAKWGWFFRTYMQWQSVAFALSEICARPPGPEVDRAWRAVEAVYDERVIKNSKFQRGMLWKPLRHLMARAQELRKAQQAARAAENDTFFRDVGSSTTVETFTQDYPDNVVSLTLDAFSMGLDEPFSADVPVQPMTSGSPQGTTAMHATAAGTFSQDGSSDTSLTPGQLSLSTNEILKFGWSPSLGDFAGRQEPFQRFFMNVQEEWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL88</accession>
    <name>A0A0D2BL88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239566.1">
        <property type="nucleotide sequence ID" value="XM_016377996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL88"/>
    <dbReference type="GeneID" id="27330728"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03645"/>
    <dbReference type="HOGENOM" id="CLU_033823_0_0_1"/>
    <dbReference type="OrthoDB" id="4157125at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="498" mass="56630" checksum="56B24C61AD88CA68" modified="2015-04-29" version="1">MQANVGGEYAADWLNIPRSNGSSSFGYPGQREDHVSSHGDEALAGHTPASQAGKLVQFLHAFQHLYELRKSALTLRLRTRDERNKVKASARRLQDITRRLIRDIKLQHDVTADLQALQEVIEKMDAQYMDHDRFESDLIPAEWKLKEVEKNLYEDVRGEPFLDPEWSDSDGRSSPKVLPELSSYGITMTMTTNPPQTRGRLEDEVAALKALEQEMALHLERLESEYEEIAEDAKMRAEAGMPVTALSQDFLSRYGQRRRELLDRLALISEEIRAIEFQPFATDRPKSPTTNSLPLGQFSNRETDVLLRSYGDNGDETLQLRAEDYAAREDDLHPVLDRLKSPHANAGVVMFPMSVAALEVDSCTDSISSEEPPDSSVSIVSNWLSHYFTASWWSAVRFAFEHYLDNTFSYVDIKRYMTDVWSREVGLPMANKPYGSEWKSAYTYWLPGTGDSSPPPVNPPARSHIFHSRPPKRRHSSGDSRTLRLKTHVVHSNRPNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLB5</accession>
    <name>A0A0D2BLB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232200.1">
        <property type="nucleotide sequence ID" value="XM_016383577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLB5"/>
    <dbReference type="STRING" id="91928.A0A0D2BLB5"/>
    <dbReference type="GeneID" id="27336341"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09258"/>
    <dbReference type="HOGENOM" id="CLU_033444_1_0_1"/>
    <dbReference type="OrthoDB" id="441890at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="60643" checksum="93A23DDD5B5394E8" modified="2015-04-29" version="1">MHLERGRGLQSDKLGGIDLLKNLTIRAEALLTEFKAFQAHLESQQKQHDVEFRIFRRGVESEVKSLTKITQRISVSNNTVDASDSEVGEPTQLHALRSSNLSFYEAVWGVAKTSHAISALGKRVYVDRQPSSINEAQESLKGKSLPSTRKDILVDIVTENGLEWTKVSTISEKRLLFEMAKEGWESYGDFSNDSDTDDNELPPRRKPSKLELVRLAEDLQAASQSVRVHFQHPRVRFVLPNIKEGAYPDIDAFLADIRATGVSIQCGVLSKDVHQERGRPDFDRMTPALAPVPLTPTINIDCTILLALISDISHLRRHDMSPGCNPTSATFHKAIQRQIQSEETHPLLPEEVYPCLLNRSLHCTSDAARRMREIVQTMGTATEQLRADIILGERSFDNRSAAELRLALSEQSRHAVSENLRLPISIVDFSSTDYLSIISSEGPKTTRHNRFPSSIAARAASKLHLTDINTSVFMYGWAHEIVTITSNRVVASALLASINDMLDEGERHCWNPNEGNEDFIGPHIYVCETARSLVGKAKGKARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLZ5</accession>
    <name>A0A0D2BLZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">MIND kinetochore complex component Nnf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_00528</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240169.1">
        <property type="nucleotide sequence ID" value="XM_016374893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLZ5"/>
    <dbReference type="STRING" id="91928.A0A0D2BLZ5"/>
    <dbReference type="GeneID" id="27327611"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00528"/>
    <dbReference type="HOGENOM" id="CLU_064565_1_0_1"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF3">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW19953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24322" checksum="166CDC7729117C41" modified="2015-04-29" version="1">MTTRPSISPSPPPEAPVASTPGPRAAALQKVFAGALSSSIRANSYANFSSCFPTPAKYCPTALEGVWKQLNTRLEEECTRDFEKILEERHVIEGLNQWDSMIEDARTRKNRSVEGEVPDRPLHTLSADELYSAHVTPYLQQAKAELCSKIQTTQQDNAMMATKVNDERAEIEQLLKVLEGVIQDIEGSVAAMYVDEQNGFHELKNDVWQMEQEVAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM19</accession>
    <name>A0A0D2BM19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239851.1">
        <property type="nucleotide sequence ID" value="XM_016374575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM19"/>
    <dbReference type="STRING" id="91928.A0A0D2BM19"/>
    <dbReference type="GeneID" id="27327292"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00209"/>
    <dbReference type="HOGENOM" id="CLU_031404_4_2_1"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="465" mass="51870" checksum="D29661CC067CCE1F" modified="2015-04-29" version="1">MSGISEHPTTGVNVDGIANINPATTSQALVLRNSRPQGLRKYLYSCLVGSVAIFTTLYQTGTGLSLFGPRFDATDHAGRTKHVLSTTPLVDGHNDLPYILRQELKNRIYDPRFDFRGHLLSHTDLSKIRTGQLGGQFWSVYMECAAEGVPQLEEPTWVVRDTLEQIDVIKRLIEQQSNDLQFCTTPTCVRDAFSAGKIASMIGIEGSHQIGNSIATLRQMFELGARYMTITHNCDTPFATAATTVAQGNGDLGLTPLGQKLIEEMNRLGMLVDLSHVSPETMRDVLRVTRAPVMFSHSGAFGMTRHLRNAPDDVLVSLKSNGGVIMVPFVSYFLNKDHPEDASIHDVADQILYIAGLIGWDHVGIGSDFDGTVDLPRGLEDASKYPELIQLLMKRGATDRQIRLLAGDNILRVWSHVEKYAQKARSRMQQLPVEDVWEGRKWFHGNDQHLPPMFRDSKKERRDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM55</accession>
    <name>A0A0D2BM55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="15" type="ORF">PV08_00254</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239896.1">
        <property type="nucleotide sequence ID" value="XM_016374620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM55"/>
    <dbReference type="STRING" id="91928.A0A0D2BM55"/>
    <dbReference type="GeneID" id="27327337"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00254"/>
    <dbReference type="HOGENOM" id="CLU_027721_8_1_1"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="91"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="372"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW19680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="461" mass="52707" checksum="73CAB90C169D1132" modified="2015-04-29" version="1">MAESRLAKFAAPAVISLVAFLSYSSQYLFLGITPGPLTRKESIIFNTLVACIWISYSRACTTDPGRVPKDWQPEEIKDPSPSSAADEAIARQRYCRKCEAVKPPRSHHCRVCKRCIPKMDHHCPWTVNCVSHFTFPHFMRFLWYAVSAMCYLEYFLFVRGRIIWDDRHMPSVSICPGIFIKRLDCTANEPAREQYLGPTLPQMIHLFFLIVLNSLTLFMVSITFLRTIWGLGGNVTTIESWEIERHAKLLRRARALGGFLDGPDGIMIRITRQEFPYDIGIWSNIVQGMGTSNVIAWFWPFSPTPKTSGIVFETNGFEDPGTSWPPPDPDRMPRLARPLDPEDAFVHQHAGLSPDDELVAFKERQRADFERRAEHYGGPVKRRKPFHERFEEENGTPIENDYYSDNGDDDGDGSVSSGEEGWQDSGGNRLKDYGVDEEVEFYDEDNIPIAELLRRRRGQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM64</accession>
    <name>A0A0D2BM64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232500.1">
        <property type="nucleotide sequence ID" value="XM_016383877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM64"/>
    <dbReference type="GeneID" id="27336644"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09561"/>
    <dbReference type="HOGENOM" id="CLU_141731_0_0_1"/>
    <dbReference type="OrthoDB" id="4269at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="142" mass="15508" checksum="BCABC0A858098FCF" modified="2015-04-29" version="1">MSTLDSTIYILYNANASLLGKLNYVCRKFTASPDSSACAACDLTHGGLHLDESAAWKKTKARIGANVEQLHRDESTSEVRDFIKANALKYPVVLGRAGTSPFKVLLNSEDLLKVSTNHSAFLALLEQRAEGEKIPLVIESQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMA1</accession>
    <name>A0A0D2BMA1_9EURO</name>
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        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239946.1">
        <property type="nucleotide sequence ID" value="XM_016374670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMA1"/>
    <dbReference type="STRING" id="91928.A0A0D2BMA1"/>
    <dbReference type="GeneID" id="27327387"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00304"/>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF15">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="491" mass="54577" checksum="B209DEE157436A3D" modified="2015-04-29" version="1">MPRRQLQKSDRIVIVGAGVFGLSTALHLAIRGYKNVTVFDRHDYDASKYAYRSGADSASSDTNKIIRSAYGSAVEYQDLSKEAIEWWTAWNEELKGGKDLPPGLSSSDRVYINNGTLAFTDKDEMPTFELDTIRNMRAAGLGATQLITTNPEDVKAADHRGWGYGIDPFRRKERGKANVGVLDTTGGVVVADKACRFALHKARALGVKFVFDARAGAFETYWHDKDGKVVGVKTQDGQRHPADKVVMACGGWTPSLVPQLDGLCETTAGSIIMLKIPRDSPLFDRFAPERFPSYMWKLWDGPEGGLYGFPRDDQGWMKIGYRGTKYTNPQVQPDGRVRSVPITRYTPGEKVTHIPRKAMQVFKRFLAEYLPELAEHGIGIELTRLCWYTDSFDNHYVVDDVPGQDATVMVATGGCGHAFKYLPNLGKWIVDIMEGVGSERTLVQRWRWRALQPGTEPFNVLMQGSTSPAAIKNVSWSKDSDLKPAGSGPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMI7</accession>
    <name>A0A0D2BMI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240364.1">
        <property type="nucleotide sequence ID" value="XM_016375088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMI7"/>
    <dbReference type="GeneID" id="27327806"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00723"/>
    <dbReference type="HOGENOM" id="CLU_609707_0_0_1"/>
    <dbReference type="OrthoDB" id="4140029at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49430" checksum="77CD21383183CDDB" modified="2015-04-29" version="1">MAQKMRFTSSTPASLAEVCKLAWHTFYGMQKVSEDFENLRFEVWTIAISLDSLHSVGTTSTLIDRQPDRARWALTFTKILTSLGSALRPLHNLVRLYLSSSTKERAIVKNWLTHPECTYEGATIQDFRRKLSMLVESLNVFLSCLTHAELARAKDVSETEEWRVLSEVTKNVLHKWDSDVATGIRRPTDRIARPIEPPGYVSEDVRSYITPLLNNGSPGLGVQTIPEPPPSPMPPTRPRFDPNTQHHQPSGVSNLDDIEHGFRSHMHAMRRIREQLRQQKMNNHGLTDQSSRHFPETHSNHEHRLGGLPPPTPTTPTLQRKPTDSSQADNSVDYADASSCGGSSSLQTSETGSVISSYRGNADEDVKPVIVGVVVPHQQRSPERHERKRRRQAQYRFKTGLEDSQSGGSSDDSASDEVPGVQSRPKSALEQLLTTALFFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN21</accession>
    <name>A0A0D2BN21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240554.1">
        <property type="nucleotide sequence ID" value="XM_016375278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN21"/>
    <dbReference type="STRING" id="91928.A0A0D2BN21"/>
    <dbReference type="GeneID" id="27327996"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00913"/>
    <dbReference type="HOGENOM" id="CLU_263424_0_0_1"/>
    <dbReference type="OrthoDB" id="3946221at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1246" mass="137185" checksum="C809516EC0BB578B" modified="2015-04-29" version="1">MPRSPSFLASYHDDGLSSPDPLADSFEDGATGKRVSRPVRTSSPSKNSAATRRRSRRATGATASTPLFHSVSEQNLSPWKIKVTVEAEPEDPEMEGIAPRTMTRTMKIPLRHDSSPTNLEARFSRERNSATAPGKSKRSGTPVRGARNTSRSRRQSVTDLNVRPLGDDAEEDDWLRQKKSPRKQGTSRSRKADEGDSTSSPVKPGRKSAQAAVEVRQDTDAEDGYDGIHQQGSTPESESPELRTIDLNRVSVRGRPVSAKSTTDSMPDGDEKDPDTQQSLAKPSRQKGKEVRKVSSNSALSYPTPSPSSSFHGDPDDVEDTLQQDTEGRMTGEGFDTVLESEGFTMIDLDTLPSARQFRSSPAMAAESHPAGQERENKPSDNPDKTHALAPAGDVSYPALNADESEISSTVPSSPPVIEQDRSLLKVPAPSSVGIRRVTPQPYSSPKLPSPPRHILQRTANHRHRGSASALFAGIALQEVVSPEHSERHHSSQQKQSSVSRPLSSHEDHLFEGFDSRTKRELRAGLRFGEELAKRQSSDPADRATPGEAPARKGDVAGLGISSRHEQPKPQQATQVRRGETVVQHTPVHTSSSMGADSRKGGGNVTQTPENQSIMRQKPELLDTMARREREWQLEREAVSRQIENASESQVIIIDSDDESALPVKEQSMAEHSQCDQLHEDDEEDIWLAEAKNSSSSPLPATISDLPVQNEQHKQLHPPKEVNDKPRRGLIPRPWRRGDDIAPSVEQSTFLSTNSDEMSGLGYWKEQESKIKFGAGEIRRHQLGQRRSSGTFDIDLMLGTPKKEEDPNRSFDTNDGYHHEQSDEPAVSEDMNDASNSTAESVDAPVDALDQSISSQEETQDTSAIDDTSVALTTPPVPHQDSPDPAPSQRPPTPRSALKGSRYSVGQMTGFAKADTPTMIRRVVFSERSRGVDIDGMESSFSMKTGSDDTTLGEAGLQLRRELEAHEDEHEAGLEPDLDHDVEDAAAEESVHTVNSSASSEPTPTPKPQSRQKEERPPKRSTEPAAEVNIQRTLSSPSPISNLDGTLSPKQQSREEPNWEKAKLAMSSIDRRSNSTHRGSKTKSRLPSYLLPPSYPSDPSRPSSSRLGLSGEFTNSHFRTLHIIYRKSLRPKFHGPGREAIRPDVLALEGREMDIDETGSGMGEMFTWTIGPTECAVIERFMQEVEYSNGFYRGKTVRQDEDVAGGREDGGLRWGWTADQIGEWLCRIVVGEVVREEEKRTRGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP61</accession>
    <name>A0A0D2BP61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240929.1">
        <property type="nucleotide sequence ID" value="XM_016375653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP61"/>
    <dbReference type="STRING" id="91928.A0A0D2BP61"/>
    <dbReference type="GeneID" id="27328373"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01290"/>
    <dbReference type="HOGENOM" id="CLU_005860_1_0_1"/>
    <dbReference type="OrthoDB" id="3903581at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113720" checksum="BA1EC52E30EECA91" modified="2015-04-29" version="1">MDFEELPTRSGPSSFELLITCNPPILQSLLAQVPTDTIFRLYQTSSFLRDFLSKSPTSWRYISWRLYQPTISNAAATANGATGQRQSSNYALDQILLNIINPFSTRLVSLELDNTAVSGATLTSTVLILRRDTLRHVSVRGCKNVSLKYHINPWLQMHALARESQPARGPTGFETLALESLYTYRCRHHRRRPYLPSSLSRKESDSEPTHELVSTCHKLGIWTDTAWCTTPGARCFRRRGYVKMRMPQGTREVWVVYDRLWRSRNWLGPVETLGSNSSTPPKKRRRDGRSWEFDEEGVNGEAIGVSREGKATPAHLRQTHKDFVEDIVCHNCSAEILERCEQCSVMMHCTGCRKTLCASCAFDRPYLRNKNAPEEERNKFWWAPGYAVSPCTMQDQDQPANGANGAQNADPNLMPNIKFRWCCTEPVFSGGGGITFGNTNSRETDKIRAAPLPIGKGWEDPEFGSERPAVEDESVQQGPGGRWPSIDSFFRTAEALSSDEPPSFSIPRVLCDECYSTEHWRLKCKACATSLCLKHDIGDRMKVRICGYRDVVAERQEYKSRQKALKLLATLVRHRKERLAAEKPAAQQDQARSRPDGSSTRRWVPPNPQLPSRSEGLYDGVERDDVEAPAIGLRQALRAHRTPLADLDPPHRPLSPASTSTGPLSRSTSPTPSAHSNPATPEPSLSALRPEDEPPALPIWQGCQAFFCPATRAPGDHRRRCPAIMKQCLECRINICGDCMSTLEPPCPCKGCMAPQTEEQVSSGEHAPLFFCPNCRWARMVSGKCKRRSQAFLIAQSSSRKMKKRRDRIRKPVEQRRLGGHGSLATTEEAIDGLVEFFTSLHPTTNPTPPHHAASVSGRPPNSTAQHPPGANRPAMQALLAPMQRPLGMNHGHHYHHHVVPPHLTEFQELEDMGVLARDLIRRIQRLRDQYRPGSLAAIALPDPRIPQNGGNAADEPGTAQAPPRTPGLARPDTVAIPPPPPQQNHNAVAGPVGPGHVGNNEEIDDRESGSDEDEDEEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPF0</accession>
    <name>A0A0D2BPF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NCS1 nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241034.1">
        <property type="nucleotide sequence ID" value="XM_016375758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPF0"/>
    <dbReference type="GeneID" id="27328479"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01396"/>
    <dbReference type="HOGENOM" id="CLU_021555_4_1_1"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46055" checksum="EC4532B89F600CC2" modified="2015-04-29" version="1">MIGAYWAMIIRGIFCVILYGVQATLGGNAVRCMLEAIWPSFAHWHLNSLPASADISAPDLLCFALFWLASFPMLFVPMSSLRWVFAVKIAIMPFFYVALFTWALTAGHGVGPLFSIPTKITSGWSVGYVFCSTILATIGGNATFAVNMADITRYAKNPRSAAIAQAFALPICITMTIMAATAQVVYGEVLWNPLTIILLWNNRTAKFFAGFLFAFATIATNVTGNSIPFAHDIMGIFPRYMNVRRGQVLCAILGFAMNPWVIQARASRFFNFVGGYSIFLGPLVGIILCDYFFIRKSKPYNMLHLYRAEGLYWYWKGCNLRALSAWLTGVIPLLPGLIHNINPNIKMGRGIVEFFTMGWLEGLIIAAITYYLLCLAFPFSIVVNDGSDVVIEAKDEESVSQIPATGKPVDIVGSKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPI3</accession>
    <name>A0A0D2BPI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241069.1">
        <property type="nucleotide sequence ID" value="XM_016375793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPI3"/>
    <dbReference type="STRING" id="91928.A0A0D2BPI3"/>
    <dbReference type="GeneID" id="27328514"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01431"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="257" mass="27521" checksum="CD7C7EF2501BCB1F" modified="2015-04-29" version="1">MRKLAGGLGSTTAFRLWELGATVALLYAPFEASRVKETVKRVFGTDDPDKVHTFEADITSEASIKDVFDGRISHLDGFPSILINAAGYVSVQPLEQTSAEEAMKNFLPNLLGPFITSNAFFNLYQARVAAGMEKGTPSPPGRIVSIASQAAHVALDGHGAYCASKAGLLGHTRCMASEWGPRGITANTVSPTVTWTPLAAKAWADEAKKEKHLAQIPTGRFSEPSEIAHAIEFLCRDESAMINGADVRIDGGFTISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQN9</accession>
    <name>A0A0D2BQN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233665.1">
        <property type="nucleotide sequence ID" value="XM_016382962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQN9"/>
    <dbReference type="STRING" id="91928.A0A0D2BQN9"/>
    <dbReference type="GeneID" id="27335720"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08637"/>
    <dbReference type="HOGENOM" id="CLU_762983_0_0_1"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF8">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="357" mass="39749" checksum="F11A42AB554F12D0" modified="2015-04-29" version="1">MSRSNHDVVRDIGAYPPGDRETRKHIRTITEHRREQNRRAQRAFRERRRAKKQFLKSKPQTPRYLAPRVPDDAAVVSGAVKYSEAVNVPNWAGHTSASSTETAPPSASSHVFSDTLNLRDQRHPRSDPTPQMTFTFSSPQTLLPAHESLIPQRRTPTSELQAYFRATNRPGHTLWPQGVPATLAACLFNAAALGIDIDRVGDPKYMSPFYRPSFSATPSSSLVVQPTTTDESSTPTSTLQLPEPRSLRPCFAQVIFPHHACLDLLPLPKLREAAVMLVVRAQQEGKCVGSSANDEVQELKKDVYVCQGVRFRGTGDLRSDEYLLPDESAGHCGNPWEGGSWAVASWFAIKWKCLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR19</accession>
    <name>A0A0D2BR19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233865.1">
        <property type="nucleotide sequence ID" value="XM_016383162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR19"/>
    <dbReference type="STRING" id="91928.A0A0D2BR19"/>
    <dbReference type="GeneID" id="27335923"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08840"/>
    <dbReference type="HOGENOM" id="CLU_035914_0_0_1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="332" mass="37801" checksum="EC121BFAD8845F7A" modified="2015-04-29" version="1">MQIRKDFNKATPQERKQYTDAISCVMTFPSNLDQTQYSGAINRYFDYATVHINLTQTIHLDGFFLVWHRMFVHLFEKDMRENCGFRGPMLYWNWPSTAFDIDTTPIFNGDRYSMSGNGEYFNPGPYQVGPNFIVPHGSGGGCVTTGPFANHTITMQPSIDPLFLLTGDPLPQTVFQKNESCMTRDLNSWVATKFDNWTRVEDALKCPDQACLARELNGAFGGNDFGLHGGAHFSVGPPESNIFVSVQDPIWWPLHTMLDNLYVQWQKRHPDVQNQTWGTETANNVPPSSNVTLDTWTPDWGYFAPSMQMKDLMSTTAGPFCYDYEWEDGPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRM0</accession>
    <name>A0A0D2BRM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234105.1">
        <property type="nucleotide sequence ID" value="XM_016381003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRM0"/>
    <dbReference type="GeneID" id="27333753"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06670"/>
    <dbReference type="HOGENOM" id="CLU_034763_2_0_1"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239284" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="143"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="412" mass="43969" checksum="0BA05EFC95904CF9" modified="2015-04-29" version="1">MRSSVLLAALATAAPILANPVVKRDATTNGGTGSTFRDDPQGYMSGFRDPRITTSAGNKAICIEGMIDVAASASNYKINLEEPTRKSDVVELVVEAFQTNSTAKQQYVGAATPISGTYGIYSQLCFPRSTDSINSTTVQFLNHGAGFDRSYWNVAPGYSYVDFAAAQGYTTFLFDRLGTGLSDHPDPLQVVQYGIQVEIAHQLIRKLRAGAISKHAFTSVVAVGHSFGSIQLTGITSTYPHDVDALVLTGFTADPSGMPFAFAGWSLTPASISDPVLFGNLSGGYTTSASIEADQFFFFRAPSFDQAVLNLARRARQTLAVGELLGIPALGVSSSFTGPVDFVIGANDLPNCFGNCVLPYDKVAAAKEKLYPAASNGSDSYLAPDTGHGLNFHYTAEKAYEHIHDFIRKNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BS39</accession>
    <name>A0A0D2BS39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_01830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241466.1">
        <property type="nucleotide sequence ID" value="XM_016376190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BS39"/>
    <dbReference type="STRING" id="91928.A0A0D2BS39"/>
    <dbReference type="MEROPS" id="M67.A01"/>
    <dbReference type="GeneID" id="27328913"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01830"/>
    <dbReference type="HOGENOM" id="CLU_053034_0_2_1"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="54"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW21250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="371" mass="40884" checksum="69864D3B6FF090D2" modified="2015-04-29" version="1">MSTKSAFRNWEAENDIITVDPSQNALYTLPDPASYKTLQNDAPWKKNLNYFTNVRISALALLKMTTHARSGGSIEIMGLMTGFVSGTSIIITDAFRLPVEGTETRVNAHADADEYMVNFGVMSREGGGQLENPIGWYHSHPGYGCWLSGIDVHTQMNQQMVNDPFVAVVIDPDRTVSAGKVDIGAFRTYPEGQRPKNKSFTDDSDDFQAIPPGKMEDFGAHANSYYPLEVSHYKSTLDTHLLDLLWNKYWTSTISQSPLFTNRDYANKQIADHAIKIKDATRMQKLGVNMNRRGQELAGNGEKDFKVVKNGALEQIVRGGNKIASEEMAGLLASQVKTQLFWGVVHEARVKAAKEQATNAAAGVCVSNNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSA5</accession>
    <name>A0A0D2BSA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_01895</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241531.1">
        <property type="nucleotide sequence ID" value="XM_016376255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSA5"/>
    <dbReference type="STRING" id="91928.A0A0D2BSA5"/>
    <dbReference type="GeneID" id="27328978"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01895"/>
    <dbReference type="HOGENOM" id="CLU_002572_1_0_1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1064"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1092"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1118"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="12">
        <location>
            <begin position="395"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1192"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW21315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1219" mass="137272" checksum="2E762B85694436F3" modified="2015-04-29" version="1">MSDPRRPWPATSPTREKSHSPYRDSPSRRLRDIETGGYNSPQNRPYSSQRGRPDHEPPSPGSRVADWEPIITNMTQSELGRKKSLIRPERNRIDRDHPNYYYRKHAQNMEVFPSTTGNDPAMEDLAERRTVSSDSTAQKTALDEDFTPNQQRKAHVPGMLEPVGKKNQPRKLVRKDTRKISEEEKLRRKELDKIKPPSVWNVYCAIITFWAPDFVLQCFGMPARAQRRAWREKCGLISIILLIAAFVGFITFGFTETVCGQSGLRLKINHVDRGYMIFHGNAYDLSRSQHPAARGIPLDSNVLYDLPHKYGGQDGSFMFQEVNGDCKGLITLAPGSDVPTNADGDLAWYFPCTAFNQDGSSPVNTTVPYYLGYACHTTSKARDTFFHGLRKSGEVFFTWDDVKNKSRNLVVYSGSVIDLDLLRWFNESQVAWPAQFDDLRKNEQIRGMDITHVLQSGADKKVGKCLSQIAKVGSIDTETVGCIASKVVLYVSLVFILAIVLSKFFLALAFQWFLARKYAAPKTSQTMDPKQRAQEIEAWTDDIYKPAPKLMDPATTISGSDARTSKRGSMLFPQTSRFTSPYAVDRAAKANRAPPTTMTSQSSQAKLTQSGASLYKHGYNNSQNTLDVPTRMSIGASRSSLLLSGHESRYSVTMDNLGANGPEGFIHDNVVPQPPPEWQPFGYPLAHTLCLVTAYSEGEEGIRTTLDSIATTDYPNSHKAIVVICDGLIKGKGESLSTPDIVLGMMGDFVIAPEDVQAFSYVAVASGSKRHNMAKVYAGFYDYGPESRIAPNKQQRVPMMMVVKCGTPDEATKSKPGNRGKRDSQIILMSFLQKVMFDERMTELEYEMFNGLWKVTGMSPDFYETVLMVDADTKVFPDSLTHMISAMVQDPEIMGLCGETKISNKSQSWVTRIQVFEYFISHHLSKSFESVFGGVTCLPGCFCMYRIKSPKGGQNYWVPILANPDIVERYSENVVDTLHKKNLLLLGEDRYLSTLMLKTFPKRKQVFVPQAVCKTQVPDEFKVLLSQRRRWINSTVHNLMELVLVRDLCGTFCFSMQFVVGIELIGTLVLPAAIAFTFYLIIISIVKKPVPVIPLVLLALILGLPAVLIVLTAHRLSYVMWMVIYLGSLPIWNFVLPTYAYWKFDDFSWGDTRKTAGEKTKKAGLEYEGEFDSTKITMKRWADFERERRIQSSGNWVPQPSRPASGYGSTHNLEHYQDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSD5</accession>
    <name>A0A0D2BSD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241561.1">
        <property type="nucleotide sequence ID" value="XM_016376285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSD5"/>
    <dbReference type="STRING" id="91928.A0A0D2BSD5"/>
    <dbReference type="GeneID" id="27329008"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01925"/>
    <dbReference type="HOGENOM" id="CLU_005679_13_6_1"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="68"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="475" mass="54663" checksum="A7F6E5F0C191241B" modified="2015-04-29" version="1">MSTAEDTHDQHPHVSMAKLPLWYSSGYSQSMVRANHAFTGILSLMTWLLPECLHPRGSANNMALRPTAYLDAIRGYAAWSVVNHHLRNHTETWLFQQPPLLMLHKGSLAVDIFFIISGFVLSRRALDLVRQEREVALLECLASSTFRRYIRLYLSAAVGTFIAMVLFYFNIWSWYSLPRCESFGAQLLHWVGDVVAFSDPFADLKGWYYTDVFTSKYLFVLWTIPIEFRGSMVVFLFCTATCKFSARARTVACWLCILLCYIWQRVYISLFLFGVLLAEISLSRQSTSKDDLPVCEQKFSPIARSKRAAFHLVPITILIIGIFLSNQPVDLGLHGPNPWPYLDNCIPSWWEAGAESTIHFWTSIGACCILYAIETYPAFRRPLETSFSQYLGRLSFGMYIMHVIVQMGLYERVLNPAREVFLGESLLSYCVIYVPFMIVVLWVADYFNRMDRLVINFSRWLEKRLFAQDSGQSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSZ9</accession>
    <name>A0A0D2BSZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241736.1">
        <property type="nucleotide sequence ID" value="XM_016376460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSZ9"/>
    <dbReference type="STRING" id="91928.A0A0D2BSZ9"/>
    <dbReference type="GeneID" id="27329183"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02100"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF12">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="58408" checksum="365B3EB1B46196DD" modified="2015-04-29" version="1">MAISYLHFGYAVALLLAFAAVPLISTYLRKSKYKYPPGPKGIPLFGNLFQLPPKYPSAQLMEWGKQFGDLFTVQLGARRWVFLNSMEATRELLDRRGRLYIGRPEFPVTQDIMSGGNRIVMMTHTERWRNLRKIMHSLLMASNSETYKPFQDVESRALLWQYLKDPGRFYEHGGRFANSSTVFGRRTSMRDANVQTLFSTIDDFIGSQASPSTALVEQFPWLVKLLPRSLQWFRPEAERIYKKTVGVYEAFFDDLERRIKAGQDPKCFARDMADLAKKYGFDDAQTYFCAGSIIEAGSDTSRNQINLMLAAAAKFPEWVVTAQRQLDEVCGTAQRLPSFEDWDQLPYIVAVIKESLRWRPNMTGSGTPRALMEDDTYRGFSFEKGTVFSYNHFAISHDEKEFPQNEVFLPERFLNDDLQEMLKGHLGFGAGRRICPGWHLGTRNMFIAFSRLLYCFNFSEVPSKPINVWEIDPLAHDHPPFQIHITPRSEQHVLLIEKECAKAGQGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZ84</accession>
    <name>A0A0D2BZ84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_03807</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236835.1">
        <property type="nucleotide sequence ID" value="XM_016378158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZ84"/>
    <dbReference type="STRING" id="91928.A0A0D2BZ84"/>
    <dbReference type="GeneID" id="27330890"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03807"/>
    <dbReference type="HOGENOM" id="CLU_011786_1_0_1"/>
    <dbReference type="OrthoDB" id="3556949at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04842">
        <property type="entry name" value="Peptidases_S8_Kp43_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034058">
        <property type="entry name" value="TagA/B/C/D_pept_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="204"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW16619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="702" mass="75053" checksum="85B91A78BB34E79E" modified="2015-04-29" version="1">MSNNIVINGKSVAKSALAPDASQSNYILIQTTGDPLNKIQKAQLKDLGVNIQEFVGDDDSQLYLCGYKPESLEVIRQLPFVDYANVYQNDFVVPADIEPAAVQTAAADQTNILKVDVLLHHDVNEPSDDLVNKIASAAHVEASAISVQQGLVRLELAPENLASVAAVDEVRVLHPVKERTLFNNVARGILNANNVNVNNTIYRGNGQIVAVADTGLDKGSDTDVHDAFTGRVDKLFAWGRQDKADDPDGHGTHVCGSVLGSGTVNGEGLVEGTAPAAKLVMQSVLDRRGRLGGIPAEFSKLFNQAYQAGARVHTNSWGTPLPDSGVQHPYGAGSEQIDKFVWNNQDMTILFAAGNDGQDRDKDGKFDGTVNERSIGSEAAAKNCITVGATENSRPNLKSSISGLPYTYGGFWSNEFPKNPLKDDNMANNPEGLAAFSSRGPTAENRLKPDVVGPGTAILSTRSRNMANTSEVGVFGTLSDDRYWFLAGTSMATPLIAGCCAVLRETLLANGYKDTTNGIKNPTGSLIKALLINGANPIKGQYMPDEVGDEPNPHSGFGRVNLAGSVVTPGDKFCGYGTGILDDDQAPFSISIPVPKETPTPHQKPLGETAGLSLKVTLVYADAPGKRLSNDLNLAVVAGDKERHGNQGNQEFSVESTQPFDRGNNVEQVLWPSVPGGEIRIVVKGFRLTQDEVPFAYAWKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C1R8</accession>
    <name>A0A0D2C1R8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237815.1">
        <property type="nucleotide sequence ID" value="XM_016379138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C1R8"/>
    <dbReference type="STRING" id="91928.A0A0D2C1R8"/>
    <dbReference type="GeneID" id="27331877"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04794"/>
    <dbReference type="HOGENOM" id="CLU_2109046_0_0_1"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="115" mass="12390" checksum="9D43A3BE934E392B" modified="2015-04-29" version="1">MKSQIQEHETHSQLLNNLLLTLRDSSEAGVEETVAFIRGNSSLDAISQHLQERRLAIRSGPASASETEQASSSADNMPSTDSETREDGAPRNAAVHRPLTVSELVGTPPDKMSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C2J6</accession>
    <name>A0A0D2C2J6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238075.1">
        <property type="nucleotide sequence ID" value="XM_016379398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C2J6"/>
    <dbReference type="STRING" id="91928.A0A0D2C2J6"/>
    <dbReference type="GeneID" id="27332137"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05054"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_3_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="62"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW17859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="536" mass="57387" checksum="BE24DD8126545026" modified="2015-04-29" version="1">MASPASSYIRTLLSSSRPRVPQSLLRTSQPTYRISSVAKMSTVPKLKDPSLLISQAYVNGKFVDSSTSQTFDVHDPGSGKKIAACAELNRDDVDKAITAAAEAFKTFRKTLPRERATMLRKWYNLMQDNAEDLATLITWENGKPLADAKGEVAYAANFFQWFSEEAPRIYGDTIAASVPGNRVLTIKQPVGVCGLITPWNFPAAMITRKIGPALAAGCTVVAKSPGETPFTANALAELSRRAGIPPGVVNIVTAMKNTAEIGELLTTDSRIKKVSFTGSTGVGKLLMKQASGTVKKLSFELGGNSPFIVFDDCPDLDAAVAGAIACKFRSSGQTCVCANRIYVQKGIYDEFAKKFAAKVKDFKVGYGFDDGVTHGPVIHDRAVSKVEQHVQDAQSKGAKVLIGGQKLPDLGSNFYAPTVLTGVTTDMKITHEETFGPVAGLISFETEKEVIESANTSEVGLAGYFYSKDIGRVYRVAEHLEVGMVGVNTGLISDPASPFGGVKESGFGREGSKYGIDEYLTIKTVTVGNISNDLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C4U9</accession>
    <name>A0A0D2C4U9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S acidic ribosomal protein P1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_02898</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238825.1">
        <property type="nucleotide sequence ID" value="XM_016377255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C4U9"/>
    <dbReference type="STRING" id="91928.A0A0D2C4U9"/>
    <dbReference type="GeneID" id="27329981"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02898"/>
    <dbReference type="HOGENOM" id="CLU_114656_1_0_1"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="112" mass="11165" checksum="BAA37B9468BBE1B1" modified="2015-04-29" version="1">MSTAELASAYAALILADEGIEITADKLNTLIKAANVPDVEPIWASLFAKALEGKDVKELLTNVGSGGGAAAAAPAAGGAAAGGAAEADAPAEEAKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8X0</accession>
    <name>A0A0D2C8X0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240200.1">
        <property type="nucleotide sequence ID" value="XM_016374924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C8X0"/>
    <dbReference type="STRING" id="91928.A0A0D2C8X0"/>
    <dbReference type="GeneID" id="27327642"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00559"/>
    <dbReference type="HOGENOM" id="CLU_010761_2_0_1"/>
    <dbReference type="OrthoDB" id="4114825at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF1">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="173"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="855" mass="95029" checksum="4FD2DEBE51DA0277" modified="2015-04-29" version="1">MRRVAGRVTSDDIRSAGLRRWDGRLRVTTDWINLFHEPELCWPTGDCLVYLREPGQSSRGPAFRVHIGFLRVKGFESLVERCVVRNSIHAASECVLPNCPGCDPEQSLLELYIPAPYGAGLEEIFDHHITTRNFFAWLYNRPLAGRTLGKALVELKRRIDVYRPDDSSQNKLEVVSYAESQRYLDFRECVDHALAALHLAENLEIEDLWVDAFSHCVGMSHRGLRSSIEYAMVSSRSKSLVSRARTEMDTRLQNVDKALVDFFEEEVSNSFLRLPQTAKDHLDRARVFLKGVYVERYGSWPPSDFEEESVKQAVYTAIFGDFQNLYQHLVDPNSVTGMEETDISKTGGVCTIQNIQAFDAKHGFEPLAQPLPLIPVTLESDPGPHHSKSVRRKSWNPILKRKIDREARKARDKQALTNASNRDVLVMECEVVKKFSQFEQQTVDDDLVGLPIAEGRKVRWMLVYAILQVLHAVMQAPKQVRNSRGLTYSICCHPPKKLPWQESRRPMLPSTTESLSQLELVPDQSYSHTNVTASSSPVTEEAPRGRSFMARRRTLPAHLPGALTASLMTKSAPSSRSSSLRRLMSRCSRAAPEPMPAKRSAFCQIYVEGYGNGLNEVDSNTTAARQSTPAELTAEPTAELEVTSPDLIKEEMPEPHELVGHEVHELNAVGVESVTAPEAPLLAPVPVPVPEDESSSTPPQMSRESSSASTSSTWSKKSRGSGSDSDGLDPRTPADDTVCTLQEILQSTQTQTQTHTPKPKVPSCRPPIGKRTSSCARGSSHTIAVVDHHDSDNENGNRAGTGIGKSTYAKDALNDAMSVPSIHFNTLTWDRILDQRCVGKRPVTAPATSSIQVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C920</accession>
    <name>A0A0D2C920_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_00594</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240235.1">
        <property type="nucleotide sequence ID" value="XM_016374959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C920"/>
    <dbReference type="STRING" id="91928.A0A0D2C920"/>
    <dbReference type="GeneID" id="27327677"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00594"/>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="114"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW20019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="507" mass="56331" checksum="0B59B79D79A0DE54" modified="2015-04-29" version="1">MNRSKDERPDVGTLTGEEVAKHNSAESCWVIVHGKAYDVTDFLPEHPGGPKIILKYAGKDATEEFEPIHPPDTLEKYLPKEKHLGAVNMETVEKEVKEESPEEKERQERIKNMPPLEACYNLMDFESVAKGVMKKTAWAYYSSGADDEITMRENHSAFHKVWFRPRILVDVENVDISTTMLGTKCDIPFYVTATALGKLGHPEGEVVLTRGAKKHNVIQMIPTLASCSFDEICDAKEGDQCQWLQLYVNKDRNITKKIVQHAESRGCKGLFITVDAPQLGRREKDMRSKFDDTGSNVQNTTGDNVDRSQGAARAISSFIDPSLSWKDIPWFLSITKMPIILKGVQRVEDVLKAIEVGVHGVVLSNHGGRQLDTAPSGIEVLAEVMPVLRERGLQDKIEIFIDGGVRRATDIIKALCLGAKGVGIGRPFLFAMSSYGLPGVDRAMQLLKDEMVMNMRLIGASKVEDLTPDLVDTRGLATHTVPVPKDTLGLRSYDPLITAHQMIKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C948</accession>
    <name>A0A0D2C948_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gcp-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240285.1">
        <property type="nucleotide sequence ID" value="XM_016375009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C948"/>
    <dbReference type="STRING" id="91928.A0A0D2C948"/>
    <dbReference type="GeneID" id="27327727"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00644"/>
    <dbReference type="HOGENOM" id="CLU_023208_4_0_1"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="2">
        <location>
            <begin position="105"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="441" mass="48299" checksum="5F8EC274239A1FE7" modified="2015-04-29" version="1">MLHAVPRRSLLTLAIESSCDDTCVSILSKSTTPAPSGCVQAHLLFNEKVTLRNTGKGGIWPPEALNSHQLHLAKLIDTSLPFLPEADQSSPVEKQLRLRDGQIKEKPDFVSVTRGPGMNQNLAVGLNTAKGLATAWQVPLLGVHHMQAHALTPRLANAIERHDARSLQPDFPFLTLLISGGHTMLLHSKSLLEHEILASTSDTAIGDELDKCGRMLLPLEVQQNAPDTSFGKYLSAYAFQSPADFESWSVPRNRQEEIERPPNNFGWSIMTPMAKNRDLAFSFSGISSQIKRIVADRDGQHGRTPMSKEERVLLSRAALGTAFEHLGSRTIIALASLRDQGVQISTLVVSGGVAANDFLRVHLRRMLDLRSFDKVNLVFPPVELCTDNAAMIGWTGMEMFEAGYRTDLGCGPLRKWSMDGQSEDGGILGAGAWVLQKPPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAG0</accession>
    <name>A0A0D2CAG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_01119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240760.1">
        <property type="nucleotide sequence ID" value="XM_016375484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CAG0"/>
    <dbReference type="STRING" id="91928.A0A0D2CAG0"/>
    <dbReference type="GeneID" id="27328202"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01119"/>
    <dbReference type="HOGENOM" id="CLU_018731_0_0_1"/>
    <dbReference type="OrthoDB" id="5405745at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW20544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="67654" checksum="7DF6BE20A684B7B1" modified="2015-04-29" version="1">MPLLPKLSPLQSRFAASLAASAILLLILYLTLSKPQFAYALELDSRIHSEDHNHYVISEDGEEWDEDIAIRISGRAEAGVSALANNAPQNININTGQTQNWVFPSDAVNGPHGAMGTGLPGDGIEKRDLTVDVPELKKRQTGTRIYVSLNTCLQPSSNATNNTSDNIVPPQLTMYISLSESNQKPGQDSNDPNQQTIDVDEGYALFEGEADSDVYIGVSAPNTTDFEGIWNYEVAASNDAPFHSYRDTSNLYFVDGDNHAALLITNDTTEADSNSTIYQDWMKINPPWGVFAANQNEKTILGVSKSFCGLKNNARIAANIEGFSHQNVAKMTNRGLGGKPKEQFYVTGLNATSEYWGMLAMVGNSTASGNGVVGGGGTVWKAIDFQTKTEDNCALMYNLSFCSEVAYAVPSNPDKYPPSTGLPELAALYDSYAAQMYQYFNYSLQQIPCNTTSSAQYSLARNCDDCARAYKQWLCAVTIPRCVDYSNNDAWLMPRNLGQPFVNGSSISPAQLNGNQQLLTSVATNSSRNAIIDQVIQPGPYKEVLPCQDLCYDLVQSCPASLGFACPSAGEGLELSYGTRSNDSGIITCSYLGAAYYLSDARSISPSGVTTVVLLTLSLLAIHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y493</accession>
    <name>A0A0D1Y493_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229992.1">
        <property type="nucleotide sequence ID" value="XM_016386184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y493"/>
    <dbReference type="GeneID" id="27338959"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11876"/>
    <dbReference type="HOGENOM" id="CLU_696456_0_0_1"/>
    <dbReference type="OrthoDB" id="4160360at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="396" mass="44484" checksum="30A5464DFD7F8021" modified="2015-04-29" version="1">MIRHSIKKRWQKLGVWNSKWGVPTGELGGFGNNDGPKSWEWESLSQARESAESRAIRLHLQRQGRENENLTPQLQEVGDTPDIQVDDRESLITSRPWFLWALEVAEEAVRLQRNPKQSKIEAYEPAPGVIICLEIGWMDGATCLVGSGKMSHHRQNPPDPDEMEFTPSEIDASEAIRPSTPQPQPKSAHPERRPPSPTAHPVRSLFWNSLNAASPCSTEPTANSLTDNEIYAESAQPLLQDYAETPSRTEQRPQSSPATLRKQQRRHTTHRHLTGSNTRVTRSTRLVEVPKKPTRKQRTSQAPTSETSKLAPLPRRSPRIAKRDRHQKDAAAQSDAVKASAIAKVIQQSQLDEDIEETLSCAKRTKNGQLKQRHPRKSSTPLGATKRMARSRNVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y4W2</accession>
    <name>A0A0D1Y4W2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230177.1">
        <property type="nucleotide sequence ID" value="XM_016386045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y4W2"/>
    <dbReference type="STRING" id="91928.A0A0D1Y4W2"/>
    <dbReference type="GeneID" id="27338820"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11737"/>
    <dbReference type="HOGENOM" id="CLU_1304872_0_0_1"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="211" mass="23807" checksum="49BEE4A7FCDF4ED3" modified="2015-04-29" version="1">MSNEMAPGLQAVYVAYNLEEKGKFAKQRARQRFNRFRLEATACGFLRFPKKSSPGGFQLLLKLPRTHVLQNSKTWSNFEKDILSKYNRVDSAELKALKERITTLEKERDEIKTEYDSAVAERDEARTALQKHVDDLSTVIKNAKAEQKTVLETQFKEVLRKNRTILVERKAELDAALAEKVVLQKELDSAKAQLAVASAQGGPPKESDGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y5T7</accession>
    <name>A0A0D1Y5T7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_11238</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230492.1">
        <property type="nucleotide sequence ID" value="XM_016385548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y5T7"/>
    <dbReference type="STRING" id="91928.A0A0D1Y5T7"/>
    <dbReference type="GeneID" id="27338321"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11238"/>
    <dbReference type="HOGENOM" id="CLU_019796_9_1_1"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04901">
        <property type="entry name" value="ACT_3PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="16">
        <location>
            <begin position="416"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW10276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="486" mass="53456" checksum="57E769B0E4E52D56" modified="2015-04-29" version="1">MAPSTLTQNIKIQSQQKNGEPLRREVSRSLSMSTSPHETFHQRKMSMGIEGSSPGLIRTKGTGATPKQLKPFREQDIKILLLENVNQTGRDILHGQGYQVEFMKSSLPEDQLIEKIKDVHVIGIRSKTKLTARVLAAARNLIVIGCFCIGTNQVDLKYAAEHGICVFNSPFSNSRSVAELVIGEIIVLARQLGDRSNEMHQGTWKKVSNKCWEIRGKTLGIIGYGHIGSQLSVLAESMGMDVIYYDVVNLMAMGTARQVPSLDHLLANADFVSCHVPELPETMNMIGKDQLDTMKSGSYLINASRGSVVDIPALIAAMRSGKIAGAALDVYPAEPAGNGDYFTNDLNPWAEDLRSLQNLILTPHIGGSTEEAQSAIGVEVAEALVRYVNEGVTIGAVNMPEVALRSLTMDEPNHARVIFIHQNVPGVLRRVNEILGDHNVDKQMSDSRGDVAYLMADISSVKEEQVAELYRELESLKERIITRILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y6X5</accession>
    <name>A0A0D1Y6X5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230847.1">
        <property type="nucleotide sequence ID" value="XM_016385903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y6X5"/>
    <dbReference type="GeneID" id="27338678"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11595"/>
    <dbReference type="HOGENOM" id="CLU_1001272_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30704" checksum="44CD29283335EA88" modified="2015-04-29" version="1">MARTGSSGCYMNTIRYQAITLPETEPRTPYAVYIINKETIYCVNGNEDSPPAKVLGKAGNWPGFGAIVESAQSLYVAEQALFKVSTWDGSYKRLGSGTWEESTSMAWFGDLYIIQRGSLYSADQTTGQYKLLGRPDDWQGHTSMAAVMLDRDGVSSRRLFVIQSEKLWEVARDGTYKRVGMANWYTPAYISAIGEALYAIENSRFQYIDGNTGQYTVIGEAVYSQTTAFAGADGQAFAIDAGRLLRINIYDGSHVKLSDGWDGPSVMTVVRNAKCRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7K9</accession>
    <name>A0A0D1Y7K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231117.1">
        <property type="nucleotide sequence ID" value="XM_016384515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7K9"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7K9"/>
    <dbReference type="GeneID" id="27337283"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10200"/>
    <dbReference type="HOGENOM" id="CLU_021768_10_0_1"/>
    <dbReference type="OrthoDB" id="5341676at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="122"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="340" mass="38537" checksum="C18BBB9570F0B5F4" modified="2015-04-29" version="1">MIRQSTSGLIYDKLLDITKPNVKSIQGNRNPKTTAENRPEHLFPLRGDITVVWPLEPQLSKLLQLLPPSANSSHDPEQTLVSRPILLDLIRNGEWISQEFQKAVVRITPDIVVKICRGDGIIELSNLQHIHPFSRTIPVPKPLGILQIAQQTYIFSSFVKGVCLDRIWVDLTLQKKLSIKQQLNTIFTELRNLPLPSKDGFLGGGDPPLCLDKRRWTRKSSISIKTEAQFNDFLLSEAHTGPRLVDLVRLCLREDHRIVMTHGDLHARNIIVDNSSDVAITGVVDWETGGGYPDYWEYVKAVQIPFIGEHNDWDLFLPNNAIGTFADEYVKDCMIDRVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7Y9</accession>
    <name>A0A0D1Y7Y9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231242.1">
        <property type="nucleotide sequence ID" value="XM_016384640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7Y9"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7Y9"/>
    <dbReference type="GeneID" id="27337408"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10325"/>
    <dbReference type="HOGENOM" id="CLU_013814_0_0_1"/>
    <dbReference type="OrthoDB" id="5419219at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="825" mass="93054" checksum="51215DBD72CB2680" modified="2015-04-29" version="1">MFDMDEKLADPGGSEHASTGFFENISRSAKQRFKSKKKPRPEADVPASKPRRANVMSRNGWKLEINEDDVLEVANWNEKFVRGPLVLEDLPKFDDTLNYGIDKDEENRLVRLEVKRLIKDCVSESPLLFNSDNILGTTKPEAFKIISDFADQILCNLAIVSHDNQLLILEHSRAGVELEKAASQFKLARGTLRRKFQQNEKVKPRIPIRIEPEADNTKVYFALVDYATSSVARVLLRLASSKFWKSVNIAVLARWAVKLKVLCHDPVTYARQALSDGEAIIEQLNASEDTEMFRIIRIRIGASQRPDAGGENGYDVHEETDATQLYFSYNGMVRVWLESIFRSCILGLYSTQWFLTAPSTFEVCTVVYEVGLSHSLTTLSADRDGDVFATSQTQSISCIYVVLKLLLEVVEALKAQEQPDNSQEKTLVRWRWAEGRKGQNTVEKSLQTSSADEVISALILLSLSTSYVCDRMLKMISNISVNSEEEDPVFQFAPKHFQAKFVVASADYLSRKRRLGFTDQWYNDPETIPVSGDLFSKRIRAGTQLGLDRTRLQELPALDQPELVDTKKEMQVVQQYVKEEKRMQSWVFAETSVTVRCTGYIMAIMGLCAVVLGGGLAIPFVVRNEIVGVDPFQITTFTWLIVGVILIVAKTRYVTEWPWHDFLHGRVVCKSVSDLAEVTGVDAQLILTKLLYDERNTTVVTRGPYNGMFSRRPEGPGSDGFSIDVPAQLSTMLVSGFIILKVLSSTGEHLITLDVRKGTELDYAAHDGVDLKYLACLDLGKRDFEDEEEDQIPKPKAERRVLYLVQNKVHYTKVLGLYICDALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8K2</accession>
    <name>A0A0D1Y8K2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Shikimate-5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_10626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231542.1">
        <property type="nucleotide sequence ID" value="XM_016384940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y8K2"/>
    <dbReference type="STRING" id="91928.A0A0D1Y8K2"/>
    <dbReference type="GeneID" id="27337709"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10626"/>
    <dbReference type="HOGENOM" id="CLU_008871_0_1_1"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="4">
        <location>
            <begin position="497"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="3">
        <location>
            <begin position="620"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="5">
        <location>
            <begin position="752"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW11326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="793" mass="87584" checksum="D07FCCB225736FE9" modified="2015-04-29" version="1">MKRKAEAPDSGRELYLQEANGYAVTSVPETVSGVFSSRTSSLGRVAGHDASNTGAFLERPTTPTHKTVYNSRASILVVGFPRAGKHTLSVIASVVLRRQYVDFGKAFEKSVGTTPYDYIATHGMPAYREAETKATESLLNTYGEDYVIGGLTAFGSNAQKRLLKAFAQTHPVIYVQRDKADLGDMFGDQGNQEQLYRIHDAFYRSCSNFDFYNITWTLDTPNGRNQGGTLKLKQTEVDFVRFLHRIYGRQPQLLCSAGALSASYTYALQVPLPWLDAHVLEYDELESGADMVSLVIDPRDHATDHYLELIPKAVATLRRHARAPIMIDVLYLGVQDSVNYLKLLRLCLRSSPDFLTVCLKVDLDQVRSLSSLRGPTQIVGTYHYEGRKQTGVAEEITWTKVHDLASQLACHAVRITHQAASASENLQRLYNAQVARDTWTMPLIAYNTGSLGRTSVCFNPVLSPVVLPSMSTEGVTIKQAQTALYSSFIQSRKKFTILGQSVSYSLSPAMHNAAYAACGMPHSYGLLQSDNLGSIHELLTDPECGGLAISLPFKMQVLPMLRHISPEARDIGAVNTVVVERGQNQPGDYDTILKGYNTDHIGIRKCIERKISPANVIREGSTALVIGAGGVARAAIYACRTLGIRIICLYNRTASHAEALANHYKQQNLEVQVLSTLESEWPERLRPPTVIISCIPAHSISGQAAHELTIPDQWLQSRTGGVFVEMAYKPLVTRLMNQMHSRVTAGWVVVDGLDVLVEQGISQFEILTGRPAPVHVMRRAIRQQYELVNSALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YA81</accession>
    <name>A0A0D1YA81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232077.1">
        <property type="nucleotide sequence ID" value="XM_016383454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YA81"/>
    <dbReference type="STRING" id="91928.A0A0D1YA81"/>
    <dbReference type="GeneID" id="27336217"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09134"/>
    <dbReference type="HOGENOM" id="CLU_003613_0_0_1"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="364"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1174" mass="131543" checksum="6133F6244D5AD35E" modified="2015-04-29" version="1">MFSSLLRPARSRRNRDRSPFSSSYAPTVRSPDTSRIRAFRIRTRSEERGRGNLGQDDEHISDIEEEEDDDEDNEDEDLFGGVEDENHMLDGLDEDEAADTAPLLPIFSAAHLDAIPVFSLTHAIRILVTSRCDTVLSWEQLRSPQVSQFLLKPVEQEIRKNHLNAATHYALMANCLQYGKEAAVGTGNSGTNKTRGMVCELLAIRLLKDYSTRDLIDALSYDFDPLQGQLDAVGQDGEGRRGNAMLTKPPQRPARISCFEIAIRAQAKKFLSHPTVVKQLEAIWAGTIVFHSAADNLHRKLPFQRQSRSYGTNDAEPGTKRRSISFDGTHPRRAVTIYNPRDASLFKLSRLRVPRYRNILSTTSFAVLLILFVAVLVQRSLEITTLEVVFWFWAAGYMLDEIVGFNEQGFSLYLASFWNVFDLGILLILFVHLALRIYGIVMPDVKKLTVANMAYDVLAADAILLFPRLFSVLDHYRYFSPLLIAFRYMAADLVAVSLLIVISCSGFFVALTLSFGDDGVDSPSSVAYALLQMVMGFTPAAWDRWSEYNVLGKTILTLFLFICHFLVVTILVTVLTNSFMAIVQNANEEHQFLFAVNTISHVKSDALFSYVAPANILQWLLVPLRYCVPFRQYVRINRTTIKLTHFAILFTIFTYEKTVLQSTVFDSIDLVERRGRKRPAAQFSRLHRAPSIATFRQDKALEEVFRRPFDSTVRGERHRRKASNVVNSWMNGMGDDGAAPPQEQDRRIVDKLEARTNKPRLLAPFVRARTFSRRTMSAMSDPEDFATNADIFSADDNNAVHEPPRASPQHQPTHLSDGDDGDGDDELPTNDEGDEDETTTFDHRSPRLKPQSLQLDGELLDREYFSSGPGSANSLPHSAVSSSLQRTRHWGERPGRQSPIQPSPKHRPHQHSRNVSSTTMIFNPTDDTSAEPSSSAGQTTAVHSQAGGHLPTSGAHTPISKSAANATGQRSPKRTTAGPYRMRPFLPGKDDPAIRSTPNLSHILETKARANAVRRRPSLEMDLVSDIGDNRAIGGGYVGALPVSLAARMEKGMAESRHLRAQKQEQERFTKIMMARMNSLEEGFREVIHEMRDHMKQDELSRSRERVSRPKSRQKKVKGKEAYRPATAGGDKENVDPDTAQLEKEVDMSEVKTEDAGSRAIDEGGTAGERPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDJ4</accession>
    <name>A0A0D1YDJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233267.1">
        <property type="nucleotide sequence ID" value="XM_016382564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDJ4"/>
    <dbReference type="STRING" id="91928.A0A0D1YDJ4"/>
    <dbReference type="GeneID" id="27335321"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08238"/>
    <dbReference type="HOGENOM" id="CLU_039478_1_0_1"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000001">
        <property type="entry name" value="Agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF28">
        <property type="entry name" value="HYPOTHETICAL ARGINASE FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002236999" evidence="9">
        <location>
            <begin position="27"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="396" mass="42921" checksum="8A403958C6DFE995" modified="2015-04-29" version="1">MSSISLRLTSFLGLFLLLCSSSVVVAREIGFPPLAPLQANNGHAQYRSSFNDEKQSLVDLDKFAGLTTFSNLPWVHCLSEEADVEKYDIAFLGAPFDTATTGRPGTRYGPTGIRLGSRRIAATFSWSPYTHDNHFLHWAHIVDCGDVPMTFLDNTVALKQLETAHKIVSRRPSNATEVSTVPRIITLGGDHTTTLVALRSTFDHWGPVSVIHFDSHIDTWDPSVLGGGFSDYAGLNHGTFLHIAHEEGLILNTSAHAGIRAPALNKKYDWKNDKRCGFEIITARDIDKIGVQGVIEKLKARVGDTNVYISVDIDVLDPAYAPGTGTAEVGGWTTRELLSILDGLEGLKVVGADVVEVAPVYDNAGETTVLAAAEVAVSLMGLMVETPVKPLSKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YEJ6</accession>
    <name>A0A0D1YEJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_08669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233697.1">
        <property type="nucleotide sequence ID" value="XM_016382994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YEJ6"/>
    <dbReference type="GeneID" id="27335752"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08669"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="88"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="538"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW13481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="581" mass="63628" checksum="A59BBB83693431EB" modified="2015-04-29" version="1">MSISPADSSSSTLSTDTNRPNDVEGQKAPSPQKLSHWRMVLSPAGITDDVVNYQYKGSGTTQDPFLIEYIPFDQRNPMEWPDWKKWLITLTAAFATLAVSLVASAYSAAIPQIREEFGCGEEVATLGTSFFVLGFCFGPTIWGPLSELYGRQVLFFGTFAIITAFNGAAVGAHSIATLTIFRFIAGTFGSSPLTNAGGVIADMFPASQRGLGLTVFAAAPFLGPSLGPIVGGFIAETVGWRWVEGVMALYCGAFWIIGTLIIPETYTPVILGRRAQELSKRTGKVYVSAIEHRQGKITPAAAFQKALVRPWALLFLEPIVLMISVWMAILYGTLFMLFGAFPIVFAEQRGWSQGVSGLAFLGITCGQMLGTMYCILDNIRYKRLEKEHNGDAPPEVRLPPAQVAAIVIPVGMFVFAWTNYPRIHWIVCIIFTAPFGFGTVLAFLAGINYLIDSYTIYAASVLAASAVLRALFAAVFPLFTSYMFKNLGIHVASTIPAILAAACTPFPFIFYKYGRSIRMKCKYAAHAHEVMSQIKARQKAIQEEEQREKKQEEKSAQNEVKISPDKAAGQKIGTMNEKEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YL26</accession>
    <name>A0A0D1YL26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235967.1">
        <property type="nucleotide sequence ID" value="XM_016380140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YL26"/>
    <dbReference type="STRING" id="91928.A0A0D1YL26"/>
    <dbReference type="GeneID" id="27332884"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05801"/>
    <dbReference type="HOGENOM" id="CLU_021802_11_0_1"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="235"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW15751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="524" mass="59360" checksum="647689510C008D74" modified="2015-04-29" version="1">MVLNRHSFQPPVMHPRRRQDITNSNVFTLFNSKHFQDEVAHRLAGAVRIPTIAYDGMDLVGHDPRWNIFFQFSDFLKRTFPRVYQALVVENVSTHARLYTWQGWDETLKPMLFMAHSDVVPAGHSTSDQWSHPPFSGYYDGEFIWGRGSEDDKSNLIAMLTAIDCLLACDFQPQRTLILSVGFDEEGGADQSYGARCLANTLLERYGKHGMELIFDEGIAGIEKRFGTDFALPATAEKGYVDVTINVSMPGGHSSTPPDHTAIGFLAQIIKLIEDHPFPSKLIRHNPTLNYLRQAALLSKHMPDDLRDVILGSQSSSKLLEYLNTDRERRAMVKTSIAVDVVRGGDKVNSLPESATVLINHRIAIHDSVDVVKDHYVSLLSPWAERWNFNLNAFGRKMQHHKDGTTRTDDNNDCGDLTLVAAYELDPSPVSDTDDACFRWLAGTIKGVFGENVVVAPELLSGNTDTRYYWDLSPHIYRMSPWRASHDPRGTRMHTVDERMPVAGLLEMVKFYHEFIRVMDEVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNJ6</accession>
    <name>A0A0D1YNJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_03854</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236882.1">
        <property type="nucleotide sequence ID" value="XM_016378205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNJ6"/>
    <dbReference type="STRING" id="91928.A0A0D1YNJ6"/>
    <dbReference type="GeneID" id="27330937"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03854"/>
    <dbReference type="HOGENOM" id="CLU_067864_1_0_1"/>
    <dbReference type="OrthoDB" id="2587363at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF5">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237094" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="11">
        <location>
            <begin position="30"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW16666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="290" mass="30711" checksum="BA87BAA717F65A31" modified="2015-04-29" version="1">MKFGLNCLSVGTYIIALAQAQHGEEYSETMGPVAFMWPPDRVWGAAQDNTAPCGSASGVANRTEFPLLNGQVALVAQDESWSIQVAISYSNNPTSNDDFETIIAPTRIPELDEGHQCFPIANPPADIEAGSNATLQIKYTSDFDTDKNETFYACSDITYVPTSQFTYQVPCFNATVEDFNITEPSSSASGTAAGASATAPAPSASSKSSSSGLSGGAIAGIVVGVVVGVGFIAGLLWLSFWRRSARNKRLREHEASVRAVKWDEHLAGSAPTSRASTQDIALSNMPGNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YP88</accession>
    <name>A0A0D1YP88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_04167</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237192.1">
        <property type="nucleotide sequence ID" value="XM_016378515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YP88"/>
    <dbReference type="STRING" id="91928.A0A0D1YP88"/>
    <dbReference type="GeneID" id="27331250"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04167"/>
    <dbReference type="HOGENOM" id="CLU_010194_18_0_1"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="10">
        <location>
            <begin position="317"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW16976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="903" mass="97627" checksum="91A9F78E8F3B79DE" modified="2015-04-29" version="1">MGALRYDGQVAIVTGAGNGLGKQYALYLGSRGAKVVVNDIGGRLDGKESGKVDSRVADDVVKEIRDAGGIAVASYDPVQQGHLIVKTAVDAFGRVDILINNAGILRDVTLRNMKQEDWDLVIDVHVHGAYKTTRAAWPHMRKQRYGRIINTSSAAGLYGNFGQSNYAAAKLALVGFTKTLAKEGAKYNITSNVLAPAAASRMTQTVWAQDLLEVMKPDWVVPLVGVLVHEQCRETGAIFAAGAGHYSKIRWQRSKGFLANPESLTADVILEHWDKVVDPNCAEHTDGGGQIFQLLEKASSLPPLTSGADKKISFENRVVLVTGGGAGLGRVYSLHFAKLGARVVVNDLKNADRVASEITSSGGHALALEMSVEQGETIVRRVMDTYGRIDIVINNAGILRDKAFTNMSDDEWYSVLSTHLRGTYSITRAVFPVMLSQKYGRIVNITSRSGIYGSFGQANYAAAKCGIAGFTKTVAREGVKYNIVVNAVAPIAGTNMTRTVWSEENVRRMNADYVAPLLAALCSEKPPATGQIFETGGGWIGHTRWQRARGVDFEPQNGVPSVEQIAEAFSEICNFDNGKADNPDTPSEGSKYTMGNAMKSPKVAGMSQENSANRKYIAKIQKALTQKATPTFYTYNDRDVILYNISLGAHRTDLDLVYENSPNFQVLPTFGIVPTYGSLVSVKDIVPNFDQRMLLHGEQFLEIKRFPIPTSGTLKTESSLIEVVDKGNAALIRRGATTFDSSGKPLFVNESVVFIRGSGGFGGQKKASDRGAITAVNTPPSRAPDRVVKEKTSDDLVALYRLMGDRNPLHIDPTFSAAGGFPTPILHGLATFGISAKHVYQAYGPFKNIKVRFSGTVLPGQTIVTKMWKEGGKIVYLVEVEETGKGCITNAAAELLEGVSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSN4</accession>
    <name>A0A0D1YSN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238497.1">
        <property type="nucleotide sequence ID" value="XM_016376927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YSN4"/>
    <dbReference type="STRING" id="91928.A0A0D1YSN4"/>
    <dbReference type="GeneID" id="27329652"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02569"/>
    <dbReference type="HOGENOM" id="CLU_023111_1_0_1"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237144" description="Acid phosphatase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="51454" checksum="9A9EF4883121C7F2" modified="2015-04-29" version="1">MHYATLPLLASLASAAVGQTEQVIGAYIFHRHGDRTAKSTPPANLTDLGYQEVYTSGTYYRSRYVSSDASRRIYGLNSDLVKQSQITASAPSDTVLQNSALGFLQGLYPPVGETLGSNTLRNGSVVQSPLNGYQLIPLETVTTGTNSENSGWLQGSTNCANAQISSNNYFNSASYLATLESTQSFYDGVAPMINRTFTAQQTSFKNAYTIFDLLNVASIHNSSDNFPNADLLTPETFFQLRTRADQHEFGLAYNESEPIRAVTGSVIAAQVVDALNGTIANKGKNKLNIQFGAYAGMLSYFGLANLTAASPDFFGVPDYASSLVWELVTNATVSSSSFPTADEISVRFYFHNGTTSNSSVPTEFPLFGGSQSPLPWSDFVAGMNKFSINSQADWCKACGNSTGQCSPAALGLEDSSPVGSSSTSGNSSGGGMSKAVAGVIGAMVTLGVILGLELLIVLVGGLRVVSKKRLAGAGVAAQPDMTASGPSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYH6</accession>
    <name>A0A0D1YYH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240557.1">
        <property type="nucleotide sequence ID" value="XM_016375281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYH6"/>
    <dbReference type="STRING" id="91928.A0A0D1YYH6"/>
    <dbReference type="GeneID" id="27327999"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00916"/>
    <dbReference type="HOGENOM" id="CLU_023620_6_0_1"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.520">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.90">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10910">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="124"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="375" mass="40048" checksum="EEB9CA4855BBCDE9" modified="2015-04-29" version="1">MGATVIHSVLLFDGVSTHPNATVTFDRESGRITSVSTTPTSSTHFPPGAAVIDGQGCTLLPGLIESHMHVHNLHLPPGASEDDILRSPLRCGVTTLKALVDTWPNVTVDNAAEFVKSHKANGADYIKLMQENCCSLAMPTGAIPVATLELQTAVVKAGHDAGFPVVGHALSVDMTEVVLKSGADGLTHTFVDQPLPSSTLDLYKKNNAFVIPTLTILASLTNELQDWRDRFADLAKQKKLVDDFSVQNMRETMNAKDEAAKLEYAFDAIKTFRQEGIDVVAGTDSVAGLKGSGLGPSLWMELLLYIEKCGMSVTEALHSATALPAMRFGFSDRGVVAEGKRADLVLVKGNVTEELAALWEGEGIVGVWKQGIKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYX5</accession>
    <name>A0A0D1YYX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240692.1">
        <property type="nucleotide sequence ID" value="XM_016375416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYX5"/>
    <dbReference type="STRING" id="91928.A0A0D1YYX5"/>
    <dbReference type="GeneID" id="27328134"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01051"/>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="OrthoDB" id="10019231at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF55">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="246" mass="28037" checksum="926DC4415AA0ED0E" modified="2015-04-29" version="1">MSKECCYKGFFWDKTPVGREDTLAGYPTYITGTNPDAALMIIHDMFGWTFLNTRVLADFYAKEADVTVYVPDFFDGEVIPPEVIRDRSRWAEYDIPAGVDRRHAKPVHRDQIFASARELRSKYRKCGAIGFCFGGWAVFALGADKNLIDAISTGHPTWLTKEEINEVSVPTQILAPEHDPVFTPELKAHANQVIPTRGVPYDYQLFPKVAHAFCTRGNPNDEEELKAMDRAKDAAVYWFKFWLHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0X9</accession>
    <name>A0A0D1Z0X9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241517.1">
        <property type="nucleotide sequence ID" value="XM_016376241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0X9"/>
    <dbReference type="GeneID" id="27328964"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01881"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="70"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="552" mass="60924" checksum="96A9BB7E23DD1717" modified="2015-04-29" version="1">METYLQYRRIGRTLEKQLEAHDVESARQLPCLSRQKTKVVNGRSVLIVEWDGPDDPLNPRNWSLFRRVYATLIISAIAFMVGAAAPIDAAVLPQAAKDLGVSEVTETLAVGVFLIGFGAGALICGPFSEVLGRSGTYIVSLASMCIWLMASALAPNIGAQVVFRFLAGFSGASPLVCAGGSVSDMFTPLEKTYMFPIFAIGGFLGPPLGPVMGAWIPESPYLHTWRWAEWVALFTAAVVLFLAFCFQPETFPPLLLSWKAKHLRRITGDQRYYAAHEIERIPIATRLRVALPRPFIMAFTEPVIFLITLYMSVLYIILFTFFDGYDFIFRETYGVSQGISNTIFLGIAIGVLFGAAWLPWMYKITAHAQKEAEAQGKGQFDPEIRLWFAMLGGAPAIPVSLLWMGWTAYPSVSIWSPIIASVLFGYGTIMIFISSYMYIIDSYEMYAASALTFATLARYIIAGGMTVVGIPFYKNMGVHWTLTILAALSALLAPMPYVFYKYGYLIRRKSRFAVNRAAEGEVVPVQNDSSSSSSISIPLETDKERADEPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z101</accession>
    <name>A0A0D1Z101_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Septation initiation network scaffold protein cdc11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01916</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241552.1">
        <property type="nucleotide sequence ID" value="XM_016376276.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1Z101"/>
    <dbReference type="GeneID" id="27328999"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01916"/>
    <dbReference type="HOGENOM" id="CLU_002093_0_0_1"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="628"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="768"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="838"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="964"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="868"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="971"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1748" mass="194178" checksum="24AF2AB1451AD496" modified="2015-04-29" version="1">MEPWLDSLSEDWKSEHHSSSPVPSLSSSRHNGNSSFSRSQSRIPHLAKNMRKESTTGSFLRHRSQRSHSRADGEPILRERSASSLNLPPANGSSKFTSLPRRPSSVFSESQNSVQHHTMNEMPASAETPEWKRRLINGEDIASDGFDLFSPSKLEGIFKQPASSVLPSDNEAVENEGSIRRKPFSIPISNNFPEQYSSVRGTRSRLNLAVLEEINEEEESEHQNQPKGPHPTLEKGSIQELAEQRMRSFARIHNDNTAPSSCPSSPEEESIIQRQATSSAPDPRWRTISGQEELRNEFISPVTMSKQNSIRETIMRHPTNVDLQTLDTKLREAACDSPRPTSSSSDRAVDYGNWSRNGHEPAPARADELLPDLTSQSLPDDLSMGTQDFVAGGGFINSRRGGRSNENSFLRKSLSLSRENSRIDSQNKENFTFNSSPPQSSRLWDDSIDQSKISASAPGTPPDTSVVHHAESRSRPTSSGSPLKLFGNRDTYTNNKLMRILSHFEPEATTDAGNSDSSADEDQDNVFRMSQFGQGELDGFGFEQNVRRPSPVELGQVGSDDRIFQPTIAVADQKAQRNEAEDLANNARDAQERDRLTKRRKTIMQEQVTIHDNEVEVKISSLEEKATLAGKKRTDARPGSDPAQAEPEVLATRNLLKPKSARRSSMGKSAAGDAANTDGEEGLVELNHELTEALAAELATFTHEAVKVNEDSRKPSLATKDYMEEANKVMQFIRARGKPVPVLNQTSELGDTSELNADAILDFSVDAESTKEDFSRPPSREYPAKPPPERRHARHDSRTASYLRKYQDQDDLDVLASTSVFGTWAPSDNRLAAEAASVPVPDEFQESDPPNIRIRGHNETMRKRKHSTSTIEGPPSSQSSLQHSFPTNSSSTSGQKGVITSGTVSIPDKVGAMTFDHDKKIWVRKMQSTQSPKVLDLEGVSEDDPFENIPDLSIDEKQEIFSGAGEKQDAATGQKSVVSPPTPTSWAEPSSPRQPLQELEPEIVMKRDQALAAPRDKDEGEINLSSLRSKVSEHEVKLQSGVPSKPPSELKENRKQARVVTIAFSSPVVSGINYANMSDEDFEALPREDDLPLDESYIHLEDDIENMVPSHENMVPSHHPQNRFSLPAEDRQALTFQPRTISPIQEQDEEQTTGQMSMVNTNHFHELTPAPPRAVAKLQRSAQKATSILCLTPLSDFSLHQVDKGRDPDQSYVEDRKHPNALRQAHGSLALAVDQLVKAITDAVQDELFWEDLRRLKLDENKISSVHALKEYCPALEHLSVSGNSLRQLDGLPSSLRVLDIHNNMLNDLTSWGHLHNLQYLDVSGNELESLECFSSLLHLRSLKANNNRITNIDGLLDLDSLLDLQLSDNELTCVNFEGSELMRLRSLDLSDNKLKEVKGLRSLPALESLNVSNNELEKFEQDTQDRGLNLKELRLSHNALEAIHLKQMPALKYLDLDNNRINNIYGLSSAYDLEILSLREQAGSASVVDLILSTPNECRTIRLSSNSVMSGMFKLPSKPQNNLRELEIAACGIAELPEGFGAAFPNCRSLNANFNAIKDIAPLRRMVHLKNLLLAKNRVKKLRRTCLVLSRLGSLKQVDLRDNPLTVGFYSPVHTAVDADGPTFEARYHLPRGSADEDANWVKLLDEVTSMKRRTIELLLADHCKGLVDLDGLCFSRGQSDREDETWVRLTAQKVLVKPAQVQMPTANIAEKMTRKHGDVSIPSPSKELTIVGGEGSMIMDCDVFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z160</accession>
    <name>A0A0D1Z160_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetoacetate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241612.1">
        <property type="nucleotide sequence ID" value="XM_016376336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z160"/>
    <dbReference type="STRING" id="91928.A0A0D1Z160"/>
    <dbReference type="GeneID" id="27329059"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01976"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="7">
        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="111"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="580"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="694" mass="76774" checksum="812A063F850A2D33" modified="2015-04-29" version="1">MAQNGVNGVHEATVKLWQHPHPEQTQLYAFQQYVAKKHGVQTPSYKELWQWSVDHPALFWEDVWHYTEVKAHKKYDSVLDETLPMFPKPTFFSGCELNFAENLLFPSSNPTPESLAIIGATEQTRDRLTWSELRERVRLCAAAMEAHGVKTGERVAGYLGNHANAVIAMLAATSLGAIWSGVSPDTGVHAVLDRLQQIEPVLLFADNAVTYNGKTHETHGKISHVLADLPSIRNVAIFETIPGHHFDLPSLQRQETTTVETYTSFLSKGDASRPLRFTYLHPDHPVYILYSSGTTGVPKPIVHAALGTLLQHKKEHLIQADILPGQRLFYFTTVTWMMWHWLVSGLASGATIVLYDGSPFQPHKEMSMPLLIDELKIHHFGTSAKYLSVLEQANLLPREASPKSASLESLRSIFSTGSPLAPSTFQYVYKNLSPPSPHPGILLGSITGGTDIISLFGAPCSTLPVYMGEIQSAGLGMSIRAFSADGKDISSTGEAGELVCTVPFPCQPCMFWPPGPKGEARYKSSYFEAFKDEKTGNPIWTHGDFVRFNPKTGGIWMLGRSDGVLNPMGVRFGSSEIYNILLKHFATEVEDALCIGRKREEDVDEVVVLFLKMSSGHSFSSDLSHRIQAVVRKELSARHVPRIIDECPEIPVTTNGKKVEGAVKQILSGLNIKTSASVANSSCLDWYREWAKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZC12</accession>
    <name>A0A0D1ZC12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_11471</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230723.1">
        <property type="nucleotide sequence ID" value="XM_016385779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZC12"/>
    <dbReference type="GeneID" id="27338554"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11471"/>
    <dbReference type="HOGENOM" id="CLU_009187_1_0_1"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="600"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="652"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="42"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="216"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="394"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="819"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="867"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="939"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="843"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW10507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="974" mass="110204" checksum="E9A84AB52FE97D2F" modified="2015-04-29" version="1">MSAIKALSPRQTSSPVDPNLSPGEQVLKLISNPFQASIQINAFWASLATSLGFSAALALLFCFVRPRNTIIYAPRLKNADKDHAPPPLGRGLLGWVEPVNKASEPFLVDRIGMDAVIFLRFTRMLRNMFLILAFVGIAIMIPVNVTLGSKGASNGSSAFTIMTPLFIFGSGLWAQVVLAWFIDIVVIYFLWYNYRRVHQLRRAYLSSPEYQHSLHSRTLLVRDIPPKMRSNEGIARIVEEVNPAGAAPRARIGRNVTVLPELIEEYEETVKELESVLAKYMKNPDRLPAHRPTMKAPRKYKGTTANGKVDAIEYLTDRIRTLEMEISDIRERVDSRDAMPYGFATYDQISQAHIAAFKTRGKRPQGTKIRLAPRPNDIIWSNLKLSRSTRRSKRIMNGIWIVVLTVIWTPINAGIAVFLSNLSNLALVWPAFKTSLNAHKSWWAIVQGIASPAITSLVYLVLPSIFRRLQVRAGDVTKTERERHVLRNLYGFFTFNNLIIFSIFSAVWQYVTIVIEYDRQGNDTWTSLRKGNLFLSITTSLCQISPFWVTWLLQRNMGAAIDLAQLWHLTYVWFARTFMAPTPRQNIEWTAPPVFDYASYYNYFLFYTTVALCYSTLQPIVLVVTALYFSIDCFLKKYLLMYVFVTKTESGGQFWVTMFNRIVFAVMLSNVIIAVVVKARGTWALVAAIAPLLFIMVAFKWYCMKTFDLDLKYYSRGGMQDPEELAAKHHAHEKISSKFGHPALYKPLMTPMVHAKAKHLLGEIYRGRLDSDGGQAATLPGIAMQPLSPSKQPPSDVPFEIVPEAQQDFHFYRNRPEFRDNAGDTLSERSHTPISMSGYGKESYNSPPSSRAMSPVVAAGAGVHTYSPPQEYRGVPHRKQVDQSHVPSQFKTNKNRRSVGGGDLGLRPQGPYTDPYDDRTTLLHGVGDVRAPTGEFMSMDRWRSSSQGRDGPRTRDHTPVEEMNSGYDYFRGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZC63</accession>
    <name>A0A0D1ZC63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230813.1">
        <property type="nucleotide sequence ID" value="XM_016385869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZC63"/>
    <dbReference type="STRING" id="91928.A0A0D1ZC63"/>
    <dbReference type="GeneID" id="27338644"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11561"/>
    <dbReference type="HOGENOM" id="CLU_009628_0_0_1"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="3">
        <location>
            <begin position="16"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="874"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="886"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="910"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="953" mass="104691" checksum="0E09CE913272E74E" modified="2015-04-29" version="1">MMSTQSGTHRVIPAQLSYFAIYNPSLGPTDETVRDQIVFYYSREPEERLGRQQQEGVADTGKHRQTVGQDYLHHEEAEQHERLRQVGLAQGMVNFVKNFSDGKPLESIETEKARVVLKEVEPQWWILASIDLTQLPIAATAQNTRKTSNLGKDARLNESDAAAPVEYSSREVSPSHLLLAQLVQAYRGFLLHHASSLSELWKKHENNRRLFCYQLDRYWTRFIWNWDVLLHGNPAADLYDAVKLSGGGELGIGVGEEEWGSGEREVLEGFVSRTEGLLDLIVGRYGDAPVAELAEKQDNEPHATLATTDFAPWLGNDEDPRAQDGIIFSGMGGISKRSLITVSKWMESIYMHGEAAYGVGDNPTSRSKRRRKKRSARSDSSRDSDRARKQQREEVHPKLGSLRNKAPDLRRKAMENNAAPPGIPPPLVSAVERSLNDATARAREASQETSPQPAEGSSQKQAESGSLFGADSMMKYLSLGYGSSWTLNPRGFSAAKDSVDATADTNDASKSPDERGAQLQEMDPTPEVSDEETPFLQRLEQSIGKFLVGLSGDLENTEFEDEDDGSARSPEQDHDTGTLPASPSSSKSNRIFLRTLTIEMSPFRQTQLTDAERPSSLHNSMSDNPESAEGKTSAAASVDGAQRLRLTHEKVQVAVYVHQPFIFVFLFQLRTPNLTVPGFYRAIHHTLGPLQKSLLRSTDPERWKDRVREALLPSPDSSANGTPQRELPEIHDLIYDPAKMTLRISIPNIPVPGSLAAEGLHRTSGGSVTVSGSWYTLGIPIGSSTSGPEKSKSALVKSDWTRVEALNVYTHILNLWAATRSVHGTGGQGADAADLERTVKTARGWWVMWMKVRTANSVTPVDAGTDMEAMLVRKSQDRGGGRDTSRAQSGASGSSGRWLLREQPRARDVSGSSQDGYGQNSTGSVGATNAKGVSEGVGVDAKKWVEGLIKLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZC70</accession>
    <name>A0A0D1ZC70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230828.1">
        <property type="nucleotide sequence ID" value="XM_016385884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZC70"/>
    <dbReference type="STRING" id="91928.A0A0D1ZC70"/>
    <dbReference type="GeneID" id="27338659"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11576"/>
    <dbReference type="HOGENOM" id="CLU_090382_0_0_1"/>
    <dbReference type="OrthoDB" id="2098203at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042831">
        <property type="entry name" value="Ribosomal_mL40_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="269" mass="29650" checksum="5A9D8CA8678D1D9C" modified="2015-04-29" version="1">MSIPGLESDGNRACIPSLAKPFVSLASRNLLYLLLLAISIQSFPRVTFFESDIDNNTSKPLAAMHGSSMRAALAKGFQIPLRPSLHNVVAGPASASASATPSSTTSVTSARTWTSPFSTSVARAAKKGGKERIDRRITLIRFFLYHPTTLTPRPLRFSRNRYLRHWTIHRAWQLYRAKVKQARQLELERQYNAMREANEELRVGAGDGGRLFRKAQMKTGVWSIPERGGGVPIEYARSLVDYMGSTGGLGSGGTGIGAKAKVWDSEWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZDU2</accession>
    <name>A0A0D1ZDU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231383.1">
        <property type="nucleotide sequence ID" value="XM_016384781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZDU2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZDU2"/>
    <dbReference type="GeneID" id="27337550"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10467"/>
    <dbReference type="HOGENOM" id="CLU_022564_2_0_1"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="540" mass="59988" checksum="B0268B5965555BC5" modified="2015-04-29" version="1">MSGSHSRSLSRTSLEVPRKSIELVDPGAHELSSEGEEDHFSDASEGQKRSRPVTPVSPIPRTRIEKVDDEPSYGEVPGTPAYDKRALDAVPDEVEILSPNRSRGVSIERPTTPGGTLIPRTVVEKLDPESPSYGEVPGTPAYQQRQMDAAPDVILKTPDPTKRRPIEDDTQRERPPSNVAVPETIVFRVDSEPAHGEVPGTEAYKKRALDAAPDIVEKKSDESGNSSSRRRSTLQNNSNESNDFGDDFDDFEEGGQAGADDDFGDFDDEFQEPEVEAEDATASPVSTSQSNQIPPQPFPLIDFSKLSSVPELFAVTQAHLDAMFPSSTTEKLSFITQQEPVPDDSPIFPSDRSRSLWKQLITPPPLQSPNWTQSRIRRLFLISLGVPVDLDEILPPSKQKKLILPDINLEPSSRQSESDRTLGSVARLKARAANDSTGSVDSTQSGSAKERRSRRPKGPPPPPELDLMAVKRLCATTDEKLDGLTDEEMKDHVKELQDVTERTLELLEYWLKRRDGLRKEKEAFEEVIENLVRHARRVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZK37</accession>
    <name>A0A0D1ZK37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233408.1">
        <property type="nucleotide sequence ID" value="XM_016382705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZK37"/>
    <dbReference type="GeneID" id="27335462"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08379"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="68"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="556" mass="61209" checksum="2BAE76E98707821C" modified="2015-04-29" version="1">MGLGVQDDKKLDHVPGTVLLNDEAAHQEAITEGLKHGKGKDAHIVLSPQPSEDPNDPLNWPMWKKEVITAILCLGAMLNAGTNGPFLNASYFQISQQLNMDLTTVVLVSGYNLLAAGASGPFVCAFSRKYGKRPVFLVSTLFDIIGTAVGQAKIDYKYLLAARIIQGFSTSAFESLIVSTVGDMYFVHQRGLRISVINFILNAASSLASIICGQVFQNLGWLWLFHMFQIFCCVQFVLMFLFCPETTYVRDSHYDTDQSAEVDEKGLTELATIEHSHKEHTGEPGQGDSPGYVVPKKKTFVQELAVFTGVYSRDSIFKFLFGPFLTLLNPAGCYAVIASGLLNSWYVGSAIILAGVFAGPPWQFNAAQIGYLGAGPFVGGLLGSLVTGFWGDHVIKYLTRRNKGVYEPEFRLVFMIPTGIACGVGMFLFGYTMEVGSPAELCAFFQGVMMFGVLIGIFSTLSYGLDSFRSQSNEIFIMNMLFKNFMFYGLSNFANDWVASSGPEQIMYVFGGTSVFLSLLGLPVYIYGKRLRSWWARHDLFKILKMETSGPVSEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZLM4</accession>
    <name>A0A0D1ZLM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L-rhamnose-1-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233953.1">
        <property type="nucleotide sequence ID" value="XM_016383250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZLM4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZLM4"/>
    <dbReference type="GeneID" id="27336011"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08928"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="29953" checksum="3D7A22D106177C53" modified="2015-04-29" version="1">MALPPLLQGHVCAVTGGLTGIGRAIAILFLSHGAKVAINYLPSHNKDEDTLLSSLRTEAFEAIKSRFHSSSSSPLPGVEEDVPLLAVAGDVSRPEAGRDLVAQTVAKFNRLDTLVSNAGICKFEEFLEISPESWQRHLNTNLSGAFYVVQAAAQQMARQEPQGGSIIGVSSISALVGGAQQCHYTPTKAGVLSLMQSTATALGKYNIRCNALLPGTIRTQLNDQDLADGSEKKRYMEGRIPLGRLGRPDDMAGPALFLACGELSSYVTGAAILVDGGAFVNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZP85</accession>
    <name>A0A0D1ZP85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234828.1">
        <property type="nucleotide sequence ID" value="XM_016381726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZP85"/>
    <dbReference type="STRING" id="91928.A0A0D1ZP85"/>
    <dbReference type="GeneID" id="27334479"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07396"/>
    <dbReference type="HOGENOM" id="CLU_079400_0_0_1"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="217" mass="23679" checksum="8148D2F5869CE8C4" modified="2015-04-29" version="1">MSATQIPAGKTWFDTHKVHFEDVPVSADQEISTSEFLDAAEATTTLFDLLGSVAFTPVKNDMMNNVTKVRERQKAAPESSATLQSLCKAELASKSHKATEGLLWLVRGLDFTAQALRADLTSNAAVAPTDAKPNKELADSFRAAYKNTLAPHHGFLVKPIFSAAMSATPYRKDFYLRLGGPGTDPEVIREALEKWVAALEKLVAILKAFLASKEAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZS53</accession>
    <name>A0A0D1ZS53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235843.1">
        <property type="nucleotide sequence ID" value="XM_016380016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZS53"/>
    <dbReference type="STRING" id="91928.A0A0D1ZS53"/>
    <dbReference type="GeneID" id="27332758"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05675"/>
    <dbReference type="HOGENOM" id="CLU_046066_1_0_1"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="261" mass="28180" checksum="87D59C0A443EC884" modified="2015-04-29" version="1">MSIVNGPVSSNPVIVVVPASFSPPSLYTGLVEALGRHGYETIVIDLPSVGNRRRFSAATMAEDADHIKSLTSKLADEDKEIILVMHSYGGICGTESSKGVTKAERVLSQAKGGIIRLFYISSPVPGVGGSIATQMGENMPEFIKIDGDYMVPEPDGCAQTNFSDLRPEEGVEFARMMLPHSRISFTGTLSHSGYHNVPVSYLVCKEDLAVPPQVQEAVIRQIEAESGRKVDVHTCQAGHFPTISRVEEVSRAIRRAIGEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZSK2</accession>
    <name>A0A0D1ZSK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236033.1">
        <property type="nucleotide sequence ID" value="XM_016380206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZSK2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZSK2"/>
    <dbReference type="GeneID" id="27332950"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05867"/>
    <dbReference type="HOGENOM" id="CLU_073383_1_0_1"/>
    <dbReference type="OrthoDB" id="1057137at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="2">
        <location>
            <begin position="124"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="249" mass="26365" checksum="1B56C73287FEDF29" modified="2015-04-29" version="1">MATDSKRQNAGAKVPVALPKGEPTQPAASPVPLDMALQQVIGSRIRVTTSAPNQASVEGIVYTADPLTSLLVLNTTSAPSNSTTSTSLAAPTGSYRFLPISQITGFQLLSLPQQPSELLNPAFNTIDTNAVQARLTRNISAQQAAQARLGPKGTTPTDQALFDALSRTHPARWVGNVMLISDTYLIEKPYTAATVKLSEGLHGDIDRMRKVVDMERSKVTLKLSKNLIDGKMAADNIGKVFTGGAKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZUQ3</accession>
    <name>A0A0D1ZUQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236688.1">
        <property type="nucleotide sequence ID" value="XM_016380861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZUQ3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZUQ3"/>
    <dbReference type="GeneID" id="27333609"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06526"/>
    <dbReference type="HOGENOM" id="CLU_042179_3_0_1"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="123"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="369" mass="40930" checksum="E38785BADBE997B0" modified="2015-04-29" version="1">MAIAPPTPGQLASTPISQLSLLEKLDLFPGVLSVLGTAFYTAATGPFRGESGAYTYGQHLSAAIIRKLVKRLSTRQLQYIGEPFSKIYEKWARSNGIQPEFVTLKSGCKAFWMGDKEKAKHIVVYFHGGGFSLDGDDIHLKFWHGVQKALEEGGEHVAFFFLEYTLVPHATYPTQIVQAVEAVNYVRTELQRPASDIILGGDSAGGNMCLAVLSHAMHPNNELPDLAFGEGDKFKAIVLVAPWTTFRVDWPSSERCKYKDIVSTYAAQMWSNDYMAGRPQTPYAEALEASADWWKDPRVEHVLCVAGGDEMLIDSIDAWVEKYKSVNPDGITYVVGAHENHIEPITNTRWSTAETEQGKAIKSWLKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWM2</accession>
    <name>A0A0D1ZWM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_04263</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237288.1">
        <property type="nucleotide sequence ID" value="XM_016378611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWM2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZWM2"/>
    <dbReference type="GeneID" id="27331346"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04263"/>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_1"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="13">
        <location>
            <begin position="69"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW17072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="612" mass="69207" checksum="9D47924FAEFC0211" modified="2015-04-29" version="1">MRIGRTAQAGLGRLTGWICTTCRARQTQDRATYTYNAPTTAASVGRIHTRTYSSSPPLKRGKLPDTPARTRFAPSPTGNLHLGSIRTALFNYLLARATQGQFLLRIEDTDAKRTIPGAEERLYRDLTWAGLNWDEGPVVGGPYGPYRQSERLPLYQQHIKSLLSTGHAYRCFCTPERLDDLNRRRHEKGLSLGYDRKCAHISHAESEERASKGEKHTIRFRSPDTWPRYNDLVYGKSGHGAEKTKKLLVDEPVYEDVILIKSDGYPTYHWANVCDDHDMHITHVVRGSEWMASTPLHVALYKALGWTAPLYAHVPLLVDENKQKLSKRNFDSDIASFRDKGIFPETLVNFAALLGWSHTQKNDVMDLAQLEKLFDLKITKGNTIVSFNKLEYLQVRHARRRIQSRGPNFEQMVRDLAVAVLDRYGARNVTEFIGTRPLQEVLASMLEIESFKYRSPTDFADQLSIFFEPVSLTAAHATPPDVDASLLHYLRVAAATVCLVPQTSWSESVHLSQLKSLEMSPDESVDAARWKRDLYHYLRWALATGPKGPPVAKTLELLGREASARRLQAANLRAQELMAASSKPKIETETFKGNADGKRRFEKEWTGHSLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A1W7</accession>
    <name>A0A0D2A1W7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239148.1">
        <property type="nucleotide sequence ID" value="XM_016377578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A1W7"/>
    <dbReference type="STRING" id="91928.A0A0D2A1W7"/>
    <dbReference type="GeneID" id="27330304"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03221"/>
    <dbReference type="HOGENOM" id="CLU_028616_1_0_1"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF33">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW18932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="66650" checksum="F0E54B238AAEA13C" modified="2015-04-29" version="1">MSSKQGRKESRKIESLQHEVLLLKQRFDNQQNESHTLPRPSAAPVSDGSPSNSLDFRTTASGQSPTLQQNLPSLSRKRTRSQFEVEDGCVPNFVAKGLVSTEQAELFFEAFFQGCDRFVTIFDPLHDSFQSITARSSFLLDAIITVGSSVVDDTNPSLSTVLHFQLKKMVNLVIINQEHACLETVQALLIIACYSAERSLILAFATRMAVDIGLPDAYEELTRRLVNTDTADISDDSTLDDAALMRRARAWFQLMVLEQILRVDAGNIRAFQLRGKARRCRILLNQPFSTVLDLRLLSQVELNALRAKYHESLSMCSKGDTDEVMSTVRDAQIDIDIWFDDWQSIMKRVPVKETPVLLLNLEIQQYWAKVVVLCRAIRVLGIENISEMSDSQRHLLSTAKVSLKKHLRVILDQPQNYLAHFRYAMDFVWAKAAYCFLLLLKLARLLPEDDAAFNLQLLNDGYALLSQLNKAGGGSSSGGGRSQTSRMYLQVLQTSVQKFARAVQEDPMNAQTLPIEQSSMATTDSASPFNFFWSGSSYNTQQEIDSFVPEQFVFEWDFPGLTLFSSSGVGDSFLEEFLLGPNVDTDSWFLGAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3L7</accession>
    <name>A0A0D2A3L7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239688.1">
        <property type="nucleotide sequence ID" value="XM_016374412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3L7"/>
    <dbReference type="GeneID" id="27327127"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00044"/>
    <dbReference type="HOGENOM" id="CLU_2589776_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="80" mass="8560" checksum="D2D070BB88D4FACE" modified="2015-04-29" version="1">MSQGDLPTHTDMSAVDETPAAAPATNGAPLKDTVINSKVRTPSEAPVVITRRQTADTDVDQLTIPQDEYLNLSIHPSNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4M2</accession>
    <name>A0A0D2A4M2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein s17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239998.1">
        <property type="nucleotide sequence ID" value="XM_016374722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4M2"/>
    <dbReference type="STRING" id="91928.A0A0D2A4M2"/>
    <dbReference type="GeneID" id="27327440"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00357"/>
    <dbReference type="HOGENOM" id="CLU_029378_0_0_1"/>
    <dbReference type="OrthoDB" id="2336871at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238160" description="Ribosomal protein s17" evidence="2">
        <location>
            <begin position="23"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="36094" checksum="1266EE41CFFF73D2" modified="2015-04-29" version="1">MKTTQAMMLAVAAMGFGSGVFAQGNKGGNNGGNNGGNNGGNNGGNVLALNPNNVQTGSESAGNTSVAGTSPSKTDNANFINVCTGKTLTNGKQVTGGSCNGITMGDIPSNQNMVSAIVLFPGPGEDIAANSPFTVKVQLQNLVAGSFTDAQATYYAAPQALQGGNIVGHCHVTIQDLGGSLAPQQPPDPKTFNFFKGINDDGNGQGLLTADVTAGLPAGFYRICTMNSASNHQPVLMPVAQRGAQDDCQKFTVGQGNGNNGGNAGNAGGNNGGNANNAGGNNGGNANNAGGNNGGNTGNAGGNTGGNTGNAGGNAATTTSTGGNTASTGTTGGNAGANNGTGNGGGNGSGRGRGGRGRYGRGRFAARDFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5Q5</accession>
    <name>A0A0D2A5Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240313.1">
        <property type="nucleotide sequence ID" value="XM_016375037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5Q5"/>
    <dbReference type="STRING" id="91928.A0A0D2A5Q5"/>
    <dbReference type="GeneID" id="27327755"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00672"/>
    <dbReference type="HOGENOM" id="CLU_049749_3_2_1"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="258" mass="28884" checksum="E4731CCE147520C5" modified="2015-04-29" version="1">MATEKQMYDDVAGDYDIIWATPAVRILWTLLDNNLQKLDDWKGASVLDLACGTGIGLREARKLGATKLVGIDISNEMIEVCKATTKDVDQFQLHVADCSQPLDHLGLEPGSFDLVIGMWLLNYAESAGQLQGFWSNIAKYLKPSSGTFVGIIQNQETFQPESMKTLKYGAMESNIQQLPSGDGVKMHVEFDTQPKVEFDTFVLKQDVFESTAAKAGIEISRYVRPDKSVLTKEEQDNIAWWQELLDEYPNQLVIAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A640</accession>
    <name>A0A0D2A640_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA repair and recombination protein RAD26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_00832</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240473.1">
        <property type="nucleotide sequence ID" value="XM_016375197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A640"/>
    <dbReference type="STRING" id="91928.A0A0D2A640"/>
    <dbReference type="GeneID" id="27327915"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00832"/>
    <dbReference type="HOGENOM" id="CLU_000315_7_0_1"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22254">
        <property type="entry name" value="CSB_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000039">
        <property type="entry name" value="DNA repair protein Rhp26/Rad26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058951">
        <property type="entry name" value="WHD_Rad26_CSB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25875">
        <property type="entry name" value="WHD_Rad26_CSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="397"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="732"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="223"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="917"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1046"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1087"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="69"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="917"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1046"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1087"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW20257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1194" mass="133980" checksum="3AE04FA87CF6C536" modified="2015-04-29" version="1">MEESDKAIDPGIMDVDPTISDSVASEAVAHADSDETLRLRNLDAHVQDQDDLERNIGRKADRLLFEQANQRDQQRLEKSKAQREKLQNQIRKVREEISRPIGITQRTKLRRDVDRMQGQIQSLDDDIADIEGRMHDRETQAGQVDEHDASSTGRLPNETQRDFLIRTGKITPFSKFGLSTHGESSATLEGALLDAEEETGLAELNPDLADGKVMSHRNLRQPGFASNFVDSTTEDDSSSDQPRKRRRLVRNTKKAGDDDSYDESSQHDETMTDSVDEAEADSMPTTVGKKKRVRQNQLAGIDDDVEDFRGIDDGNEAVYRSRVKKWALRRRRARKHVLGAEANEITEDDDPDTITKEEAHLPHPEIPDTVFDQGYKLPGDIYPSLFDYQKTGVQWLYELYTQQVGGIIGDEMGLGKTIQVISFLAGLHYSNKLTKPVIVVCPATVMKQWVNEFHRWWPPFRVAILHSSGSGMINVQKEATKEDRLLDMEWDPNRGRQPLTSAQKAARRVLHPILEEGGVLVTTYSGLQTYAPLLIPVDWQYAILDEGHKIRNPDTAITIYCKELRTPNRIILSGTPMQNNLIELWSLFDFVFPMRLGTLVNFRNQFEIPIRQGGYANASNLQVQTAFKCAETLKDAISPYLLQRFKVDVASDLPKKSEQVLFCKLTPLQRRAYQRFIGSGEMDAIMNGKRQALYGIDILRKICNHPDLVDHKRLSIQAGYKYGDPAKSGKMQVVGSLLELWRDTGHKTLLFAQHRIMLDILEKYVKSLSGFKYRRMDGNTPIQLRQSMVDEFNTDPDLHVFLLTTKVGGLGINLTGADRVIIYDPDWNPSTDLQARERAWRLGQKREVTIYRLMTAGTIEEKIYHRQIFKQFLTNKILKDPKQRQTFHLNDLHDLFSLGNEGAPTETSELFKDAQVQYGSTSDAKQKSAPSTAKEQTTAVPDKGIEALPGISSMEQYAGEVEEEQKANKEGANNSEARMMEGIFARSGIHSAVEHDAIIDGTKPGKVMADPVLVEQEARRVAAEAAKELRRAGEIARTIPVGTPTWTGQFGVSGRPQETSAQRAFSSGPRARGAGIQSSSLLAGLQQRQAGLGSSRGTTPRTLSPARSSASPASVSRSGTPAIPQGKDFGKLIRDYLSSHGGSVYTQMLIDHFNRFCTTPQATAEFKETLKLIARLEKGSRGRGRWVLKDEYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A861</accession>
    <name>A0A0D2A861_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241173.1">
        <property type="nucleotide sequence ID" value="XM_016375897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A861"/>
    <dbReference type="GeneID" id="27328619"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01536"/>
    <dbReference type="HOGENOM" id="CLU_494340_0_0_1"/>
    <dbReference type="OrthoDB" id="4119947at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="562" mass="63900" checksum="13543C54D6DC6877" modified="2015-04-29" version="1">MDRGEGRPRVWVNISHPSQASSGDALSIVRSHIGKYYRNRATSEQRAQLFKTSKSSSHKKEPWDVGPLLRVGKAPRTIGPEPPPEEQHRTTIEQQKQGQVVLSAARNKHPKGEAQQQGTEHFIKPCSEDGDENKTTLHDEVSGRNDWSTVAFEMASDYFQALYNDHEPLKPFPLRGADVIDPFRTSTLSRHPNSFTLLRFYQDWTPVRRMDLDLHDELVLLPLLAYNATLMTNLNLTSKKDPAVHNLIGRALHIVRESLQTPSRTRFSPMSSALSFLMMCSLFQSDHEAAQAHLQGIKSLLFYFGYSFHDLPLSIQQMIIYCDLASRVPSLGRPIFDVMAQENQSKGTSILPSSPFRLARGKLKELSLVYKDDHSRHILQLVTIVLDSFDDAMSRDPREENLVVQIMYYRVYVSLVDLDEIPLVHYNVIQWRKKQLLQLLWRLALVVPIRHEYAGLFNHSVDALESVLESEQNTQHPLSGSNDVGDSADSDASHSRQNISSRYAHFLGRDEPSNMNDLVLGYADVHAEMTALEHVPRDNVSLLLRRQIYGPIFLHHPVTPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASM1</accession>
    <name>A0A0D2ASM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_12002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847503">
        <property type="protein sequence ID" value="KIW09718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229934.1">
        <property type="nucleotide sequence ID" value="XM_016386309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASM1"/>
    <dbReference type="GeneID" id="27339085"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12002"/>
    <dbReference type="HOGENOM" id="CLU_1875460_0_0_1"/>
    <dbReference type="OrthoDB" id="4123433at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="136" mass="15062" checksum="DAD1478ED67DAFB2" modified="2015-04-29" version="1">MPASAAVTIPIAVAFRQPPLSVILAPGTWLPHTNSSGCYYLNTQPCLCGSSGYSGLDPRLPQDFVPTMANDPIPFYQEYMSWSDQSTSDFALWADSTEEAHEKDLSTTSNRIDDDVSKLPEHQAPEHDDDLMNWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVL3</accession>
    <name>A0A0D2AVL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10072</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230989.1">
        <property type="nucleotide sequence ID" value="XM_016384387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVL3"/>
    <dbReference type="STRING" id="91928.A0A0D2AVL3"/>
    <dbReference type="GeneID" id="27337155"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10072"/>
    <dbReference type="HOGENOM" id="CLU_007003_0_2_1"/>
    <dbReference type="OrthoDB" id="2162761at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF4">
        <property type="entry name" value="CONIDIAL DEVELOPMENT PROTEIN FLUFFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="188"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW10773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="549" mass="62278" checksum="F0F66941E6B8266F" modified="2015-04-29" version="1">MPRDTAGHNSPVRGDKDPEKPQDQPVHTGDLEQRPFSSFNLVGPSRLSYLSRLILTDNEPAPHSYPASSWTQATNDDNLVQHLITLYFCWEYPVFASLSKEHFLLDFHNGNQRFCSPLLVNAILALGARYSDLPEARKFQDVPSSAGDHFYEEAQRLLGYEDVPTLTKIQALGLMSLRQASCGNDMSGWHLSRIAMRTALDLGLHLADSQDRRADRLLYSNPERQVSAATFWGCYTLEQAWSLCVGREPQVTPEEVLVHKPIKIDEIEHEHWRPYSDQGVDPDPTLHQPSNIRSVYKVFAELAQLVHKTNLCLQSEDTQEITLSVRALYTEHLQFYSSLPDALRLGRNSTPPVLFAHIFYHFAVLLLFRPFFNTGIFDTVPVTRQICVEATENILSLLKAYRNLYTLRRTPAFIPYIIMSAELARMADHKTRTEGREVYRTPSIRYLRELALAHPFAVRAILICKFFLDGWKLELAPEDDCDVPYALAKNEDGMALSHSVTFFRPDEDLERHHTGLASSSPLSHQPASRLRFAPFPQQGAHLGSMGLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXE6</accession>
    <name>A0A0D2AXE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_10688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231604.1">
        <property type="nucleotide sequence ID" value="XM_016385002.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2AXE6"/>
    <dbReference type="GeneID" id="27337771"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10688"/>
    <dbReference type="HOGENOM" id="CLU_002311_0_0_1"/>
    <dbReference type="OrthoDB" id="2130597at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024146">
        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="5">
        <location>
            <begin position="917"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="577"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="926"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="979"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1181"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="592"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="942"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1065"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1183"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1232"/>
            <end position="1241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW11388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1384" mass="152907" checksum="245E91DCCE1FE89C" modified="2015-04-29" version="1">MSSPPGSPFSMGSPISQASNVLTPSRKVQALLAQFEDSDSDSPPIEHDTSPRKLSQGHNGHSSFDGTPSVQEEGTREEHQDEDEDEDDLPVAPRSRMAARLLGPNQVQLSGEMGDATTAATQLRSSTLESEKGDVARPEMKRRLLTKRKSSPIRRHASRSPTAASPASLPSPPIRQQPSQADSDPEDGDDQSNVGKSKFLALVEKHRKQRLEKEAEEVAKRKMREEKLRSLERNNRHLRGSSPADDTEEETDNSGNEGAKKLSTQTRPMRKASKKALEEMNRETQRMSRNMQLAHQARTKKKITKDSLLARFNFLVAGSSSRNVTDQETDRPATGSSRAGSVNEGSSTHDTPPTSPMNEEHRDMFKEKLSAVDASETPAPTIPLDAANSQPAIANLDKGKRRARSEEPVPEVLLVRPGMEHLTQKPMREFSQILKPTIKPYEQKKPLLSVSKADNDGSDSDLEVITSKGDVRKYAAFEHLPKRKAKEAPSHLALRSLAHLIGGDERKRAMNAAELEVSLRRAARLQARQERQQKIEELKARGVIIQTSEEREREQQDVEDLIEKARQEAVEIQKREKALAKKEGNYVKGAFDDDDSDDDEDFEVDDGGDASEESDEEENDGEEDDAHDIGNENLLDDEASEEDSDDQQQASDGDPVAEDVVEPEEVGVSVARTKRRARVLSDDEEEDDDDKGNSLELPPAAKTPQSVLRSARKQIPGLQMSDDLPMGLTQAFAATMADSQSQGLEEEQDSLRMTMDLPSPNIAMAPRVQRLDSIDVITDSQPATQTQPLNVNLSFSESQNLPQSPISAVEIHGRQFTPSQPQFEPTQDEGYILSPFAGNRFAQETPHDLGPTSTVDTVIVPHDVQDSPIVQRTVRLRRGRAQADDSDDDNVSANVSAFEVMHRAAKKKESEIFDKTKSKAREIIDEAAEESEDEYAGLGGASDDDVNEEENEDDRAMIDEDTQVGVGDEAKLAKLFADREREQDEAAVSKLMKDITTGALRRKRGNDDLDLSDEEDAANRRREAKRREFARMRRELLKDEAVGKIAEDKKKEAFLRSIEDRDVSDGEDDFDLPETQPEDDSQEQAPESGNEGTNQTGPQTADRFPQPLEQARESRINQAKRVIGSRAPVHLTRKPATLAEIRESVSFLIEEPDSQAATIDLGLSDSEDEPEAYVNLDRHFQEAEADENADDGDDLGDFIVDDDDSQAKQEDNNAAGSFKKPSVPYSKTRAPYSERRTRERPNVVNRLSMLRQASSSSSSSSSTPQNKMAFYTSTSSTSLSFAGKVPSLLRRATTNSSLGSIAEGVSATGVTVVNKSKPERGKANEEKEFVRKAGGGRRNAVNYRPTMKEEKMSQRAGIVKKSAVKSNKGGDGFLGGLFRQDSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYG9</accession>
    <name>A0A0D2AYG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231979.1">
        <property type="nucleotide sequence ID" value="XM_016383356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYG9"/>
    <dbReference type="GeneID" id="27336118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09035"/>
    <dbReference type="HOGENOM" id="CLU_852673_0_0_1"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36773" checksum="2BA635BAC1FAE961" modified="2015-04-29" version="1">MATVLQVQRLQGRPGGDCFWYHRGGAIAALNKDLSDSKPQVTDAMFCAVGMLAYIESRVPDLRTHSASMHIAALDRFLEMRHGMLSVELYGMLLRLSLWCDINPPLTVPPVSNPKASVDATSNVKLPIFSRHSDPTLSPSDVFDDIRRLVALREEYGCDPLPHGRDRERSLAYLELVSHRLHRTARSLPHSLLVSTAETIVLRCIRLGQILFMYTVSPAMSVSGVYSRSIADALRLCLEQTNPENGDAVYWSPEVLCWLLFNGAITNQAKVTQKWYFSRLREFLHSQSISHFDQVEVLLRKVCWLEDQFGVACRTLYRDLVLAVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYQ7</accession>
    <name>A0A0D2AYQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231741.1">
        <property type="nucleotide sequence ID" value="XM_016385139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYQ7"/>
    <dbReference type="STRING" id="91928.A0A0D2AYQ7"/>
    <dbReference type="GeneID" id="27337909"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10826"/>
    <dbReference type="HOGENOM" id="CLU_007383_6_4_1"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000358">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 39 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="378" mass="43355" checksum="7E574F08BF15FB04" modified="2015-04-29" version="1">MQACQPTTLALRAARTSLPKRIQRRNLQDVAITRTGKPILRVQGGRSSLGGHTATVFGANGFLGRYIVNRLARRGNQVVIPYRDDMGKRHLKVTGDLGRVSFIEFDLRNTQSIEEAVRHSDMVFNLIGKNYPTKNFSLFDVNVEGVERIAEACAKYDVDRFIHLSSFNADPDSPSEFFRTKAQGEQVARQLFPETTIVRPAPCFGFEDNLLHRLAGVNNFLTVNNMQERFWPVHAIDVGEALERIAYDDTTAGETFELYGPTNYSMAEIAEIVDREIIKQRRHINLPKWLLKPVLHYLNKVIWWPILGADQMEQECLDQVIDRSAKTFKDLNMEPAELRDLTYQYLQDYRSSSYYDLPPATAREKQQAKKYLHVIDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYT3</accession>
    <name>A0A0D2AYT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10876</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231791.1">
        <property type="nucleotide sequence ID" value="XM_016385189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYT3"/>
    <dbReference type="STRING" id="91928.A0A0D2AYT3"/>
    <dbReference type="GeneID" id="27337959"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10876"/>
    <dbReference type="HOGENOM" id="CLU_036311_1_1_1"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW11575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="351" mass="39149" checksum="01B3C66D0A5118F7" modified="2015-04-29" version="1">MASQGGLTRRRGAGGVTSPNGDEESSRVASPGPKNYPDRTPDTAYENGENGHRIAYDPRDLTESAERSKQPKLTLMEEILLLGLKDKQGYLSFWNDNISYALRGCIVIELAFRGRISMQNDSGRRRFPLADRIIEVVDDTLTGEVLLDEALKMMKSSEKMSVSSWIDLMSGETWNLMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPVVDSGAKDEIRKRVRNVCSNRTVVLPPSQFLPAELEFRMLRTISMVCAAYAANVLENALATMGHEARERAFAQVDELLAEYSQWPFAKRTGGSQGIGANIGQVVGDEVEKNKDKELQLEVVAACLSVFTRLDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZJ3</accession>
    <name>A0A0D2AZJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232349.1">
        <property type="nucleotide sequence ID" value="XM_016383726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZJ3"/>
    <dbReference type="STRING" id="91928.A0A0D2AZJ3"/>
    <dbReference type="GeneID" id="27336491"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09408"/>
    <dbReference type="HOGENOM" id="CLU_025810_0_0_1"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF203">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249313" description="CMP/dCMP-type deaminase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="272" mass="29426" checksum="05515C526C3ED509" modified="2015-04-29" version="1">MHLITFSAAVLSIGVGLCQAHSNQDSPVHPSVTADVDPDVDVNSTPDPVPAETRTYWMRRAIASLEEVGGSPCPFAAFGAVIVNHTVAGDDDSIGEEVCIGANGVQAFGNPTLHGEVAAINNCTEILTDPEGKYRLSAADALKALSDLSLYTTAEPCPMCSSAILYGNFREYIYSTPIHGDHGLLAHGWPQIDLPSKDIFSKSLGRPVRTRIVPEVLLNETEGLFVWQFKDGACPAGCVKDEEDGNRKGWCVKLYDAEEKEEDEEKHVRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZL6</accession>
    <name>A0A0D2AZL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">PV08_09168</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232111.1">
        <property type="nucleotide sequence ID" value="XM_016383488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZL6"/>
    <dbReference type="STRING" id="91928.A0A0D2AZL6"/>
    <dbReference type="GeneID" id="27336251"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09168"/>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="64"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="273"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="70"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="121"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="447"/>
            <end position="450"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="465"/>
            <end position="467"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="482"/>
            <end position="485"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="610"/>
            <end position="611"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="616"/>
            <end position="620"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="652"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="690"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KIW11895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="691" mass="76594" checksum="72257056DD5C2214" modified="2015-04-29" version="1">MAQVDTLDIIVLVVLLLGSIAYFTKGTYWGVAKDPYATSAMNGGAAKKGSRNIVEKMEELNKNCVIFYGSQTGTAEDYASRLAKEGHARFGLSTMTADLEDYDYENLDTFPEDKIAFFVMATYGEGEPTDNAVEFWEFINSDPPSFSNDSDEKPLGNLKYVAFGLGNNTYEHYNLMVRNLDKILTKLGAKRIGDAGEGDDGAGTMEEDFLAWKEPMWAALAKEMGLEEREAIYEPVFSVEEREDLSVEDDTVYLGEPNKNHLEGSQKGPFNAHNPFIAPIAESRELFTVKDRNCLHMEIDVSGSGLSYTTGDHIAVWPTNAGMEVDRFLKTFGLDAKRHTVINLKGLDPTAKVPFPVPTTYDAAVRYHMEICAPVSRQFLSTLAAFAPDEASKKEMTRLGSDADYFKEKAASQMLNIAQIVSSVSSQPWSAVPFSALVEGINKLQPRYYSISSSSLVQPNKISITAVVESIRIPGAGHIVKGVTTNYLLALKQKQNGDAEPSPHGLTYAITGPRNKYDGIHVPVHVRHSNFKLPSNPSKPIIMVGPGTGVAPFRGFVQERAEQAKKGEEVGTTVLFYGCRRSTEDWLYKEEWDEYKKALGDKLIIFNAFSRETSKKVYVQHLIKENGKLINDLLQQKANFYVCGDAAHMAREVNDVLGQIIATERGVDEKKAEQVVKSMRSSGVYQEDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0B2</accession>
    <name>A0A0D2B0B2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232361.1">
        <property type="nucleotide sequence ID" value="XM_016383738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0B2"/>
    <dbReference type="GeneID" id="27336503"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09420"/>
    <dbReference type="HOGENOM" id="CLU_047037_0_2_1"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="371" mass="41304" checksum="19EF54BCA7DABB1E" modified="2015-04-29" version="1">MCIVLISTAHPSYQLILIDNRDEYLNRPTDVARWWPEPHSHVLGGRDMLREIHGTWLGVTRTGKIAVLTNYREDTTPPPSAVSRGAIIKQFLSEDVGPVETFVRDVVNTGIAKDAGGFSLVCGEIGAKLAVVSNRAEDQSQVPWIGGDVVQTVGLSNAAFGDRTWKKVLLGEELLLDTIRYNVEHDASDEDQLIHRLLDLLSHDTLPRQGKPHDAGLEAYIMDLRHSIYVPTLGRRDSPQQQPQQQPQQQQPQRNIPDDEMAAAKLREKVDVVGFNTPVRNNSPAPSASMSQTPGQERTELDPVARPQLGVSGLYGTQKQTVVLVDRDFNVRFLERTLFDQDSNPIPPGKGDVDVRFKIERTEQNTEAMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1M1</accession>
    <name>A0A0D2B1M1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233054.1">
        <property type="nucleotide sequence ID" value="XM_016382351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1M1"/>
    <dbReference type="STRING" id="91928.A0A0D2B1M1"/>
    <dbReference type="GeneID" id="27335108"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08025"/>
    <dbReference type="HOGENOM" id="CLU_002893_1_1_1"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="8">
        <location>
            <begin position="13"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="9">
        <location>
            <begin position="419"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="7">
        <location>
            <begin position="784"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1049"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW12838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1205" mass="131574" checksum="6D431FB5FB29C977" modified="2015-04-29" version="1">MSYVVPIHRPSGVRHAIKLNFLEPNVDTLVIAKANRLEIYEQGAEGLTLLHAKTVYGYITILEKFRPCSSRTDHLFVGTDRYQYFTCSWDSTTKQLHTEQSYVDLADKVLRDSRELDRCHIDPTGRFMTLELYDGVVTVLPFVQPSTKRVKRESASNTVGRLGEPVQVRIEELLTRSSAFLETDPDSKENPKLAILWEDNQENPQLKIRELKYYPGGEQATADLETVAELNGDQLDKGVSHLIPVAAPYAGFLILGDHAIRYVDRDMNNVITQPLDDNATIWTCWTKIDEQRFLLADDFGRLFFLMIEVSDFEVSSWRLDPVGEASKAACLVYLDEGYVFVGSHSGDSQVVHIEEGGVRVVQTFPNIAPILDFTIMDLGRGAEGSQSLEFSSGQARIVAASGAWQDGTIRSVRSGVGLEELGTIGELAHVTDLWGLSSTGESDIHDTLLVSFVTETRIFKFDAEAAVEEVDEFQHLDFTQPTLFATNLPDRKLAQVCEGGLRITDLESGMLTLDWKPRDAAAKITAACANSVHLLVVEGGHTLHVFHSANSDSKPTVSRTLPLDSQIASVTVPDSQCNVCIVSFWQTATVAVLDLHSLEVLHTQSVGTPGKDIPRSLLVANVLREASPTLFVAMADGTVLTYSFDTGRNSLSGMTRILLGTEPAFFKQLLKDPGSGSGLSNVFASCEQPSLIYSSEGRIVYSAVNAESASRVCDFNSEAYPGAIAIATPNELKLAMIGRERTTQLQTLPIGETVRCLTYDANAKLFAMGCVRRIMESGTEALLSAVKIADEVSFRELDSMELQDRELVECIVSTGSFDTEDTSLGEMFVVGTSILEEDGLGGEDVMRGRIIVYEVNKEKKLKLVTQINLKGACRSLAMCDGKIVAGLVKTVVLYGLVPSSSRGGSLLELSKLATYRTSTNPLSLAVTPATQDAPAQIAVADLMKSLSILQVIPPNPDNFEYSLRETGRHFATLWSSATAVIAENEWVVADMEGNLITLRQGQGLQDTEGDNSRRRLEVTGEFRLGEVVNKIVPISSTPAPAQQQKGKANSENNNNNGNNSNGNSNSASASAAADTAGLDPKVTPRTGPLVTPRAFLATVEGAIYMLATINPAYVNVLLLLQSALAGRVQAPGYMPWTKFRAWKTEVAEKDEPFRVVDGEMVEQGLLALGDGELETVLREGGLMEDNVQVSVEEARAWGDELRRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3S4</accession>
    <name>A0A0D2B3S4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233739.1">
        <property type="nucleotide sequence ID" value="XM_016383036.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2B3S4"/>
    <dbReference type="GeneID" id="27335794"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08711"/>
    <dbReference type="HOGENOM" id="CLU_001347_1_0_1"/>
    <dbReference type="OrthoDB" id="3548913at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064:SF1">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1362" mass="152698" checksum="ED49F69811CC50FD" modified="2015-04-29" version="1">MSVYGEGTQMSNREIPFAHMRVHFEDFANELRLHRHQEHRKRILFHRRDKLRTAVALASRLHRVGSWLHDGLVAISRQSEASGFSRVHHRMQDLADSCFSSWRHEIYAYEISPDMKTPMKDSFLSRLPAYSQDDCLELIHTLRSKPRFLVERFKAMSPAQIVALSTAPKYRELSESVLTSLSQNSGRGSQRRRINAYSKELEDYSSSFERTNPLSFIIHNIYGPFPNIDSKESRLRFSTWSSVCATLMVESQQAFHALIGQLLSAFANMYAWQIKPRLELYLMSVLQRGAFLLDMVEHPFPISQSEFALFDPFNTQEARKFFQEAVQELFDILACDEGLPIGALSLGRAIIGKLPTEELQSQFRGLFFFEWFLRDFLRVAIAFPEDEKLLHQFHVSDRARSYLLHTIWDRAYTRARDAFNPIPADPEDVGVNTCVSNMINQLDAEMNCFDPYCASNPASTPFSEAFISISAADVVHTLEALNPQYIHTSSPWDPFLSSSHSTFSRQYAHASGRFDTLRRRILEAIEPGQSSRNIHPCQENWALIVISEDGMPIPTRSIEMAPMSDGLGELDIAEKAAIRLIEGSPSSSDRASTVSISAERMRGSSLSRLFAEEARLALVGHDSVTSMFWHDAMSFLRQSYPLTVLTEDDTKILAPMSEKLRVGHLRLGEECLRLEQEVARLDRSYELAKSKMSQLSTWLEKLRIKLWYRMYVVSSDAYEDAKNVSTALNNMALPALHGSSAGRGVARSPGTSRPGTSVTSTSSLFEQTKVDTMSILKAPAEHGGPKKLADSQIERTKKWLERNHLDNFCRGEERIHRFCMEVSMATKKLVGETLGDSPVLWSSELFGRERERYDVHSAGSFSAQPSSRAPSVWSEPLSSTSYPSRSAFGGGRASLYSPTSGKLGLDLASVISSPGRANTVTTVDSNSSIWSPPVSNPRSVTSVSSQSRPASTFEDSSLHRLVDHSLEKATFLENLSHDLTCLLLSDLACPVWSCGSETDAWINTVLQTPSIRERLAQRSVMARLLSRKHPLSRLVHATGRKKNGRHRRSQSTTPSTSNPHGSRLLPKDPLEDILDMTNLDPGSDGFSYRQGFDDVFTRISEHVDPSLKLEAIHDLLMLSQACQQRCPNPGTDPANSPAAARRQSLNPSVLSANLERRSHATDKAASMSGTNTSGESEVVQFLKRLLFLFQPKTMFRDLQYVAAFVSSDTLNDTEIGRGFLQVGLAALAWKDEVCRAMVDVADRIVAKDSIKRRVQRGERNEPSILKAAEYWVIAAREGNAIAQRELAGLYLTHPEVPPVISAPLSLSSEIFKIDMMWEEQEGSGRSSLAMCLALHWMQQAAENGDEVAQLKLRERLTGLSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B480</accession>
    <name>A0A0D2B480_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4048 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233701.1">
        <property type="nucleotide sequence ID" value="XM_016382998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B480"/>
    <dbReference type="GeneID" id="27335756"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08673"/>
    <dbReference type="HOGENOM" id="CLU_016967_3_0_1"/>
    <dbReference type="OrthoDB" id="4097086at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025122">
        <property type="entry name" value="DUF4048"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13257">
        <property type="entry name" value="DUF4048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4048" evidence="3">
        <location>
            <begin position="231"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="526" mass="57637" checksum="A731FD40130AD068" modified="2015-04-29" version="1">MVTKSRPMSTQSLMTVPESLVDTGVDTVLDVSTPLSPTQTSGTVETASKRHAKGLSLNFPILLPFNAQVSASPTAGSSILQSPVDSARSSPRPRPTPLTSPSLHENEREVNQIGSTDFLTLLAAQERRVLELKEELQRAETDLLGLKKKWAAHEANKKRNEVKHVKQLQPLARNDVGTREPSEDEVDEERRRKRAIVERSHLALVSPSYGSTPSTGLTRKGSKRVFEGGRHTRTLSLLSPTSSKPNQASTETSVDELTGYDNDTAAINTDPNVIQPPLSLIPTLDSLIAGEPLQLGFGKTYKDLAAHRRSVPSADVFVKQGKQVYDGVRDGLWTFLEDIRQATVGEEGISGTVAQQRPVRAPQRRATKESMNHSGHTTTESRKTPPKESSFWREFGLDSPQRPGSKSTVKADKSSRHIQQKSSTDSSNPPSLLPDSNDHEDGMDDSWDAWDSPASVRDKADVLDGKRGNGLPWPEIEKITPSKLTKTVSDLMREWDTSPDDADTVTDGSDSRLRGARATILDHPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4D1</accession>
    <name>A0A0D2B4D1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233726.1">
        <property type="nucleotide sequence ID" value="XM_016383023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4D1"/>
    <dbReference type="GeneID" id="27335781"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08698"/>
    <dbReference type="HOGENOM" id="CLU_2558304_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249462" evidence="1">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="82" mass="8796" checksum="80DCD15A1D961B2D" modified="2015-04-29" version="1">MDPPRHIRLDLVSVMASATLIVLGGGCMGEAPARQDVPHDEASPAPWQLKSKSVEILGWLPFQVDTDIGAFAILLAGKVLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B502</accession>
    <name>A0A0D2B502_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234189.1">
        <property type="nucleotide sequence ID" value="XM_016381087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B502"/>
    <dbReference type="STRING" id="91928.A0A0D2B502"/>
    <dbReference type="GeneID" id="27333837"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06754"/>
    <dbReference type="HOGENOM" id="CLU_056562_0_0_1"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000075">
        <property type="entry name" value="BZIP transcription factor (MetR)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="166"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="262" mass="29731" checksum="2B469046432BE907" modified="2015-04-29" version="1">MSSYRGRTGPNFSEYLNNLNTLTPYDQENFSPEEFELNQDLAMFTNTDFTHFDIPPLPEDGSFNFDMNENKNNSARVKYEDLLSGSETGHNYPPPQIETSAAESSHYYTTYNTPIQPAPAQGFGGVESRGSPNAGPSAASQAPRKKDSVDLGAMTPEEKSRIAAEEDKRRRNTAASARFRIKKKQREQALEKTVKEVQDKNSQLEAKLRQMEVENKWLRDLIMEKNGLQSKEEMAAAYQQYRKDSEEREVRENDHTTGVGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5C5</accession>
    <name>A0A0D2B5C5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06874</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234309.1">
        <property type="nucleotide sequence ID" value="XM_016381207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5C5"/>
    <dbReference type="STRING" id="91928.A0A0D2B5C5"/>
    <dbReference type="GeneID" id="27333957"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06874"/>
    <dbReference type="HOGENOM" id="CLU_057574_0_0_1"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31888" checksum="F97B4CBAB4D8FB5C" modified="2015-04-29" version="1">MVTTSGFTHAPVSRFLILCSVGASILTSILDIKHLLAIKPSPHLWPYLQLSRALTFQLSYTSSTELLFSTALLYHFRVLERVWGSRKYASFVAVAFALNVLVLPGLTVLLKTASFGVYNYLPAGPVAVVFAALSAWADEVPRLYRYKIVLAGGTETEAETTARSSQGAAGAGGAGGTNGVVLSDKSTTYVLAAQLALSQFPYQLLPAAVGWTVGSAWMGELLPAGLARWRVPAWVVGETSPRKERGQYEGLRRRLEEEGSSADGMRNVSDNAHDTHTQDERRGFGRQVLGYFTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5J2</accession>
    <name>A0A0D2B5J2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcriptional adapter 2-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_06974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234409.1">
        <property type="nucleotide sequence ID" value="XM_016381307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5J2"/>
    <dbReference type="STRING" id="91928.A0A0D2B5J2"/>
    <dbReference type="GeneID" id="27334057"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06974"/>
    <dbReference type="HOGENOM" id="CLU_004447_3_0_1"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="8">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="397"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="398"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="514"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="673"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="599"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="76487" checksum="25B72513366D80AC" modified="2015-04-29" version="1">MPNSEQSPAALKHEASEDPAMATEEATAPQEAEAATQGTSTPAETGSATDGNPADASKPSAAADEATGEVEDAEMGGVEDEAKGKDAVLETGNDGQEGLANEAVDGQSEQTKSALEAAASSHLVAQTHQIILPSYSTWFDMTTIHPLEKKSLPEFFNSRNRSKTPAVYKDYRDFMINSYRLNPIEYLTVTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDPQTRPAHIGPPFTGHFKITADTPRGLQPFQPAQKTITTPGKPHPSTDRAKSATPASKADLNLEVRRNVYDDKGKEVKASEEPGKQENGDGPSANGETKAMVSAAKAPIKTFNCYACGVDCTRSRFHYAKSDTVSNATGDNKYDLCPNCYLQSRMPSNHRSSDFVKMDEPAYSHIPDKNAPWTDSETLLLLEAMETFDDNWEAISKHVGTRTREECVLKFLQLDIQDPYLEDGPLKGNGIMKALSGRSPFNQSDNPVMSVMAFLTQMADPKVVAAAAGRSIEVMQKEIRAQLEKGMGGGEADSTKGKEKVKAEDTMEVDESAAETKTDADADGADAAAAVVTDVATVGTATAAARSSGLASYEERELTRMIGAGVNLTLQKLEMKLSQFSEMEETVQTERKDVEKSRQQLFLDRLAFKKRVVDMENAFRQASLKNPEEGMRMMRDAVNSNANQRFGFQDGTDEGSGGQPPLMSKGTEEKRTIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B625</accession>
    <name>A0A0D2B625_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lupus La protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Lupus_La"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="La"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
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            <begin position="104"/>
            <end position="196"/>
        </location>
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        <location>
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            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="109"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="443"/>
        </location>
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            <end position="73"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <end position="407"/>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="KIW14353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="50198" checksum="690B6578AF358505" modified="2015-04-29" version="1">MAEETVTDALQTPVDHNAAAAEDAKKLLAELQGDAEQKQELGETATVDKAETDASDKKETGGKDREHRDDRAHNSRGGRGGRGDRRGGYGSRNNRNNSKFDPTSQEVTNDPVAIRKQVEFYFSDSNLLTDTFIRNSIKDSENQSVDLITIHKFRRMQRFQPFEAVLEALRDSTFVELTDNETRVRRKDLPEDWDDPNRITVQENAATPRSVYVKGFGDEVASTQFDIEAFFEPYGPVNAVRLRRANDKLFKGSVFVEFKTEELAKAFLALDPKPQYKGNELQIMSKREYTAKKAEDIKSGKIVPNQSKFRSGRRDDRNGRDHKRKRDEEDTRDWRTRRDEDKKRGFRDDKRRGDRGNRGGRSYENKTDEKGIPTVKSSAGPKDSGRDDALAKARAAVEEETKKEQGKSAEQQNGSAEESTGKKRAREEDGEAGPESKKVDLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B638</accession>
    <name>A0A0D2B638_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Peptidase_S9_cat"/>
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    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        </location>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
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            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37413" checksum="007BE9DA043742FA" modified="2015-04-29" version="1">MAGITQIPHHDGYTSRTFIYKTIDGLEIKTEVAWPETTKTSGPVPVLLHYHGNRFSFLPSWLIGSCVSRGWIFVTPDYRLIPETTAHSCLDDAVDAYNWVLTKLGPEIGLDIGKVIIAGSSAGGYLALGTSCLVSPKPQAVVTIYGMLDFSDNRYLNDSSLIFGMPPIDSSATLRKLEDLRQQERPKVISSSEVPVTVDPNAVPRFEYILALQGERLFPDYVTGVPGMRRAIVEKGIEAIPPEHRRLFPVAFGLPSDLPSFLVLHGRNDSAVPFTASEAAAHALKKAGVKVQTEFIEDAEHGFDDRLEGASNLDALPDGGDDSSASQVRALKNVVKFLEQHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B681</accession>
    <name>A0A0D2B681_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234421.1">
        <property type="nucleotide sequence ID" value="XM_016381319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B681"/>
    <dbReference type="STRING" id="91928.A0A0D2B681"/>
    <dbReference type="GeneID" id="27334069"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06986"/>
    <dbReference type="HOGENOM" id="CLU_001373_0_0_1"/>
    <dbReference type="OrthoDB" id="5288142at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="971" mass="106718" checksum="5AACFB4D7DA4ABB9" modified="2015-04-29" version="1">MAYAAVSQAEHDGIYSQSPDLTLHTDQTLPETSSPPLSLSFDHVSRDGYHSDVPQADADGSGGAHLGKLLKSLSSSQSYEMVEDDDYDEPMRTPQGLGLNTKAPAPVEDDALAYQSEQAPIRTASISRDLPLNHPTPDLHTLQGAFVKNVEKLEESAERLSMTSSLEEELTKMKLDQRRLERQSSAPITFDNPGHSTVQRQFSSSSWSNSILRVNQTARSGGYSPSAYITSPTGSIHSGRRQQQHNLDRHSSKGSRHDQPLNEPPLEGRPLDFGVSSRPSDAAIVPDQEFVQSPGASIDSSAEDRPPTSSSNDTYRQAQAAFHDFDGVYFNSGALSHRSDSISRHISLRQPPLARDSKAFREAQPGERMIYYPAPVPVMLNLPQRLSRMDLSERERRRLQGISAIPEDLRKSAPWLADQDNTKLPGGRSSLNLPPQLRANAFFEQPSITQDLKLKNGSAVRTLDDILDAAAYAPVSAFTDHPIAGHLGKEVYGQIGSPRKSMQSTEQRKKKRRSSLSTLLKSKRSSTGLDGAALGRSKSKGSRTPLDGDENPSDDEIDRAAAQSLAPDEDEISDGEDDAEDAAPQGFFAAPTTLLAELQMRKAHQKQRNRTAADAFPNGMHSTLLELDAVTQLQQKARKTKHVTLAWEDHDEADKQNFDDDEVPLGLLFPEKDRLETFNAHRPVGLLERREMEDNEPLSHRRARLRGEPLQSMKSETKAPYIEQIPGLSEDIPPEHEDETLAQRIARLKEEKEHANEGNFAAELSQELGLNVGKSEALPSTTPDPEETLGQRRKRLKEEALRNGRQVSGESAASATRPQLRSMHSLADILQAHPVGVQDRKVSNESHGFATRNSHVQGPLLNFNGPAPPSHMRMQPGHAGTWGFGQQHGAYMNTGYGNFYQNNGVATNGGGFGGIAPSLYGAPIPMHMQQPMAGYPYGYGALPYIQDPMSGPPLDPKQRAQIDRWRQSVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6N8</accession>
    <name>A0A0D2B6N8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C3HC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234739.1">
        <property type="nucleotide sequence ID" value="XM_016381637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6N8"/>
    <dbReference type="STRING" id="91928.A0A0D2B6N8"/>
    <dbReference type="GeneID" id="27334390"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07307"/>
    <dbReference type="HOGENOM" id="CLU_031412_1_1_1"/>
    <dbReference type="OrthoDB" id="2592092at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="7">
        <location>
            <begin position="78"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="8">
        <location>
            <begin position="260"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47249" checksum="B6969BCBAEAA4362" modified="2015-04-29" version="1">MSYAVETKKRKFDRILEALSDGATSPSRSSLNTRNNTSTTTLTQDSASDSSKRRRVAPTSKVIVTSSSTTSLSGHYLPSSRSAFLQRLETFRHVTQWHIPSSERINAAAWAKRGWTCVDTDTVYCGACKERVHVDLEVDADSSEAKDHEDGEDGTAQDDSFAFGSEVYEGLVKRYQEMIVTAHAESCPWHRRGCDATIQRIEGLLNTKMALSGLQTRYDSLMSRADEIPEHVSLPVENLEDAHILEDFRFTESEKPHCDALKLALCGWERKGDDIIECHHCFRSLGLWLYRGESPAMDRLDAVEDHLEYCPWRSAEAQHTEVVVGGRENTDNPEPKTRHLAGWALVFQAMLKDHNKKRGSRSVGSTFTSEVELSTAGSEVSSTPAQREKKMRDLLRRIKEIKKPFNVKSLLRRKDRAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B810</accession>
    <name>A0A0D2B810_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytosine deaminase</fullName>
            <ecNumber evidence="14">3.5.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cytosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_07605</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cytosine + H2O + H(+) = uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from cytosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.1" evidence="14"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235036.1">
        <property type="nucleotide sequence ID" value="XM_016381934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B810"/>
    <dbReference type="STRING" id="91928.A0A0D2B810"/>
    <dbReference type="GeneID" id="27334688"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07605"/>
    <dbReference type="HOGENOM" id="CLU_025810_7_2_1"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004131">
        <property type="term" value="F:cytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046087">
        <property type="term" value="P:cytidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019858">
        <property type="term" value="P:cytosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000016">
        <property type="entry name" value="Cytosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF190">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="17">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00084039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW14820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="193" mass="20825" checksum="FB57B224781966F0" modified="2015-04-29" version="1">MSETDPGFIAAVEEARQGFSEGGVPIGACLVSKDGKILGRGHNMRVQKGSATLHGEISALENSGRLPASAYAGATMYTTLSPCDMCTGACVMYKVARVVIGENKTFVGGEEYLKKRGIEVVVFENQECMGLMKKFIEEKPRVWYVETLPPTLPLSLPPVLIPAYVLLESSSPPLTCLQCSNNGIHRNEDIGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9T7</accession>
    <name>A0A0D2B9T7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235974.1">
        <property type="nucleotide sequence ID" value="XM_016380147.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2B9T7"/>
    <dbReference type="GeneID" id="27332891"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05808"/>
    <dbReference type="HOGENOM" id="CLU_000796_0_0_1"/>
    <dbReference type="OrthoDB" id="423221at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF26">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1259"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1509"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1510"/>
            <end position="1520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="2106" mass="235755" checksum="0517C72A44E680AD" modified="2015-04-29" version="1">MAKGKERARGRDNNDVTHDNTFQNSDNSVAVVSGGALDARLNTKPLVSSTNVGSRRKPQLRPRPVRRVQHATDLVPATARVAVNDLPLPQHCEVVGTLVSLSRDDNNFQELNAALGAVFDPDKIQKTTFVEPVTNTNSKNRHFFRRGKSLYSGLDPTKPPLHDIDQIFLDMAEKALTRHFDEACRTFEEQALKIFTLCSGTDSPVVATSLISRALRQLCVNNFNVNHVGSCEIEPVKQAFLERNFHPSVLFRDVTEFINHATHPNDDRYLPRTAYGAPARPPKHVNLLVAGASCVDFSSLNSNRPVFDPTGQQGGESSTTFAGIFAYMETYRPNLVILENVESAKWEKISDRFKEIRYHCQVVKLDTINFYLPQTRNRTYCFVIDEDHADRVNLKVAQVSKDWVQLFAYFQKRATSPYPSFLLDDSDPRLILEKAKNFSVPSVGRTQEWDSGRRIHFVTRTQLHLGSDTPYTQMRDHPPCNMDNYASQTWAMGQSERVLDLLDIHYLNNAISAKRGTKTTNFDMRYKHRNVNYSQNVDRDLNSRKWGIVGCITPKGSLYDTVLGRPLVGSETFSLTGLPIGDLSLNKETSALLQDLSGNAMSTTVVGAAILSAILAIQKQQVGFFDSYVKAARSSSELKPSSEMMLLPSRQTAQESDIFNHETQQAGTLTLPSLEYLVDAMNRSTPYCHCETSGQHAAAGLIFCPQCFYTSCTTCCRRPHGGMENLIIDSRRPSDDFARELTLMLPAVLDMKLACSINDLPPFSWGEQSSRNEKFSDQLRYLLFTTLNETVRFREVKFDRTWRVIYDSKFAKLELEFIPGPFRSKDGKDSSTPLPIWRLFAKPRDTEPVNSKLRSLFQHQIAEMSVDTNLLSGSWAFWNGVSKQKVKIQAHGSTVPSWRSQLGLEHESGIDDRVFTRLEVKAPDNYTHGRGDVLNSSFGKYVLLPNCPAACQTLHKKVSANDSNASTFMYLKPDPLQDSHLDSVVISTQPAHRNMQDERSTLTKFRRGWIFPHGPNEHLSPSEQEVECEVFNNWTLLPELSMCPAAEENEFKLSRPRVLPPPEYTRKSCDDAGLTIFSLAISLDAAYKDQWTLEEPIFIEIEDKPEALKDFVAFLAHATKLLDPPAEWKTVSVAAGWSCRTCLPKLPDLEWVVKDNVLTAFENPRQAKEFEHALEIRPKAATAIVVRSTDTAHLTVKINLKTLAHRASSLLYEPGRLELLSTAQWRIVPYNRFALHPTFGPFDLSSNDSDVPISYGVVGNRTLWHSQRQILSWMQNQEEKPEKWKELSQIECRVPSLGLNTEVKAFSEKIIRGGIIADCVGGGKTTTSLAHIYHGYISGRLTKDSTSHDSSGLIDSDATLVLMPKNILAQWVKELNECIPSWTVLTRTKNDKTVKPCDTKPIGPYYIVVTKTSEILDYSIEDFKNAALILAPFNILEDDQYYKNLQDQACAPHVPNVPGRAFKQWMDQAMHGLRSVCGFLPSDTAQAWNNWEKLRSEIPNYDRFPETLTRKTKKAQKSGKSKTAASNDESGETSEATFRKDFEEKLQAFQDKDKFEPLFHLFHFSRVIVDEFTYVAGKCLLALLKINAQAKWLLSGTPPIHDYDGVNTMAKLLGTRVSTFNEQDGKFGFGKDRAKMVKDKSDAQRFRYLQNVLSAGYKKSMYEHAESFLKIFVRKNKPSIEGIKVMSHEHYFTLSASETVALDMMNDAIAKGQCDFTRKSPNSKQLEGGLRGQIQAAAQSCGSPEAARLCLSSFLHTILDLKEQGAQQYEEKGLSLLKHQLEAQCLTLADNLLEHLRGLWHADGCQTATKVFDDLIDDINNAGTEETDVVPLLRQMSQYAEANPKPPVPNWDTLKAIQKGKAVDNRTTRVRELIPSLSEGMGKLRFMNLVSSVVRSEALQACNACSKPVVDYDKVHISVKCGHIVACSGCASASSHPLGCCNLFRPGGIKPACRFVVRQLDPSVQHVADVVRGTMAQAAISLIKGRIPPGESVVVFMQFAWTRVLFVEGCRRTGIAAYDAWGGDTSSIEDFKEAAGTGQAVLALKVDSEDSAGHNLQVANHVVFLGPVMGMTGAERAATMEQAVGRCRRHGQRKLVHVWHLAPESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BA96</accession>
    <name>A0A0D2BA96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol:H+ symporter (Gup1)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236129.1">
        <property type="nucleotide sequence ID" value="XM_016380302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BA96"/>
    <dbReference type="STRING" id="91928.A0A0D2BA96"/>
    <dbReference type="GeneID" id="27333046"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05963"/>
    <dbReference type="HOGENOM" id="CLU_021430_1_1_1"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="72582" checksum="DD2CA6344E964A7B" modified="2015-04-29" version="1">MTVASFFKELYSLDTLDTRFTTSSSTPLKPANGTALTKASAEKDGKPSIPTDVSPPKWRTPEFYFYALVFLFCVPQMYWAVVEVSQPDSPNYSKYEHLLSQGWLFGRKVDNSDGQYSSFRDNIPYLAILVVVHPLLRRAYERLSTPSTPIGSNDAKQTSSAHVAEQRLRRRTSFDFWAALIYIAALNGTSMLKVLLILLINYRIATALPRSAVPVTTWVFNIGILFANELTQGYRYTSIGHALAPLVPSAVEWGRTLDSYGGLNPRWEVLFKITILRMISFNFDYYWSLERSRAGSPIEVSYPSASRATADSEVASTDNVKKKQLDPAALSERDRVAMPAPAWAFASFRTYVAYILYPPLYLAGPILTFNDYISQSSYQASSISTRRTTLYGIRFLLTLFCMEFLLHTAYVVAISQVKPDWSTYTPFQLAMLAYFNLHIIWLKLMIPWRFFRLWALIDSIDPPENMVRCMSDNYSALGFWRSWHRSFNRWTVRYVYIPLGGGPGGGSGVARGLLNMLAVFTFVALWHDINLRLLMWGWLVTLFVLPEVLGTMAFPKSKWKNRPTAYRVICGIGAVANILLMMAANLVGFAVGLDGLMGLVHGIAGSWQGAMFMLGACGALFVGVQVMFEHREEEKRNGIRLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BB29</accession>
    <name>A0A0D2BB29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236429.1">
        <property type="nucleotide sequence ID" value="XM_016380602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BB29"/>
    <dbReference type="STRING" id="91928.A0A0D2BB29"/>
    <dbReference type="GeneID" id="27333347"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06264"/>
    <dbReference type="HOGENOM" id="CLU_082438_3_0_1"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000030">
        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="147" mass="16532" checksum="48BE33260E00C50C" modified="2015-04-29" version="1">MSNVDIKVAGWKLVEVGRIVTIRQGPFAGKLAAIVEIIDAGRILVDGPSTKEDAVVPRQAIFTSTVTLTPWVITIPRSAGTGAVKKVWEKQEVDKKWSESSWAKKREQADRRKNLTDFERFKVMRLKKQQRFETLKAQAKVRATAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBM8</accession>
    <name>A0A0D2BBM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">PV08_06041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236206.1">
        <property type="nucleotide sequence ID" value="XM_016380379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBM8"/>
    <dbReference type="STRING" id="91928.A0A0D2BBM8"/>
    <dbReference type="GeneID" id="27333124"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06041"/>
    <dbReference type="HOGENOM" id="CLU_054229_0_0_1"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="370" mass="40184" checksum="7B6C8892B9B784E7" modified="2015-04-29" version="1">MASHRRGLSQASETVAGSTTTNRNTAATPTRNQGRARAPSTMGRHPPNSVLLYDPSQQEKTTSTTLYLSPDKLRRFPPGSCGPFTSLKLPPKPVEVNAQNPGSPSAATSTPSLVADSPSSASPSTTTTPVANEQASSADFEARSLGKHSSHPGLVFGVRRHSNRDEALAQTVQRKFLDLLAIPSAGNIPQQDSSPVHYETFPQADDMAPVKDPSNVHSTIKDIIQHLYEIQMQTHGYVPETQDLLVDKMTDLAESLAQLQTLTSPRESPHNPIHTVQIAPEIVDYVDDGRNPDIFTRDFVENVQRGNAVINGKQQAFREFSEIYAKALKEGIPGISRQVDAVMESVGFSSEDHEPTKESNLENTKSESAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BC96</accession>
    <name>A0A0D2BC96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein IBD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236799.1">
        <property type="nucleotide sequence ID" value="XM_016378122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BC96"/>
    <dbReference type="STRING" id="91928.A0A0D2BC96"/>
    <dbReference type="GeneID" id="27330854"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03771"/>
    <dbReference type="HOGENOM" id="CLU_017965_0_1_1"/>
    <dbReference type="OrthoDB" id="4174342at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="62030" checksum="86F5BACB2BF3EC75" modified="2015-04-29" version="1">MARATSPGTIERGIQVQSRVLDPTDLGRSGSSYLSSPDTPSTAFPERLIRPLPKRSIKSRLSQEAAESITYPPSLPSTTLPSYAHYGENGDYPNDSKVLVHHHSDGYDHDHDHDHDHDHDSDHHDHDCPHHHHHCHHDDYDDDLDDLDSIVPVSHYLSSSPRSGRHPRYSKGSISGPDGYEAFENTNNKKKRKIPTSGSLNLHHSSMTNEFSHMGLNHDGSADDAHYNVKNTSGNAGLGLQGAGRGRNARKFPGRNPLGVSVNGSNARSFPSKYDQSLTNNTKAEDTKDQGIISAAIANATALLRKPLGKGQENVGVLDQQAKQAHSTSQFTFTCETDAKGVTFPEQSLYSPGYNQRNIAPHAPSGTSSKSAQTAQSSMPPTNAPTNSTAPNASGGNAQGKKPRRRKGDVYVLAARQRRLQQEYNNLQHPPAPEDIWICEFCEYESIFGEPPHALIRQYEIKDRKERRRLAEKRRLLEKAKLKGRKGHRKLKKSSQTHQPTPPEEPLPEFADNHLDQLVDDGLDDTYDDPVPVQAPAASANTKQPGMGGANANSDKAGGTGGGGGGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCI4</accession>
    <name>A0A0D2BCI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">POT family proton-dependent oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_03876</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236904.1">
        <property type="nucleotide sequence ID" value="XM_016378227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCI4"/>
    <dbReference type="GeneID" id="27330959"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03876"/>
    <dbReference type="HOGENOM" id="CLU_004790_4_1_1"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="613"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW16688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="72368" checksum="76C7558C1AF88219" modified="2015-04-29" version="1">MQQIELRALPTGASRVSTSSDRSDTEMVHFRGSLSLSDAKAVRTRDGDSPTDEDLKTLPRVADRISWSVYTVAFVELCERFSYYGTQILFQNFVQRKRLTPTGAALNPSGDTNNNPGALGQGQQTATALSTFFAFWCYVTPLLGAWLADTYLGRYKMIMVSIACALGGHFILVAAATPSSLQHTDSALATFIVGIIVFGLGTGGFKPNISPLIAEQIVTDKLRVETNSDGDRVIIDPAQTSARIYNWFYLFINIGALLGQLSMSYAALYIGYYLAFLLPTILFLLCPLVLIVYKSTYRLNPPQGSVLGPAVRFLFYATRGQWSLNPIRTLHNLRTHDVWTAAQPSRIPARRRPSWMTFDDAWVAELRRGVQACTVFLWMPIYWLTFNQLQNNLISQADTMRHTGIPPEIVSNFDPLALIILIPVCDLLVYPALRKSGWVRVTPIRKITLGFWFGSAAMIYAAFLQRYIYAHNACGMYPNEGLPLDSSQLGADPAAAREDCPPADVSIWWQTPIYVLIATSEILASVTVLEYAFTKAPRNMRSMVQAFSLCMTAAANLIGEALIWLARDPLLVWNYAFMGFVAAVAGGLVWRFHGHLDDEEDAMNLLPQGHVGVKSTQRGSADLRRRSGNVGEEDSEGSEAEEEDHLMQNVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCS6</accession>
    <name>A0A0D2BCS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome c oxidase assembly protein COX15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_06472</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236636.1">
        <property type="nucleotide sequence ID" value="XM_016380809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCS6"/>
    <dbReference type="STRING" id="91928.A0A0D2BCS6"/>
    <dbReference type="GeneID" id="27333555"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06472"/>
    <dbReference type="HOGENOM" id="CLU_017627_4_2_1"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW16420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="63866" checksum="F873347BFADD0573" modified="2015-04-29" version="1">MLPGSGFARALREAAPGLSKRFFNCSHRNVQLRPITPSRTFSRKSTRSIYRQSVDRCTQSSVRTYAERRFECRSFSASAKSRATQAVEQDEGAQSGDADTGNKKKAGPSSSSSSFPDTSSNTVAYWLLGSAASVFGIVVFGGLTRLTESGLSITEWKPVTGSLPPMSQEDWEAEFAKYRSSPEFKMLNSRMTLEEFKSIYWMEWIHRLWGRFIGLSFVLPAAYFVARRRVSRNMAVRLLGIAGLIGFQGFIGWWMVKSGLKDDLFAPGSHPRVSQYRLTAHLGAAFVCYLAMLWNGLDILRTNKILKTAAAAAPDKAHQGVLDALKNPALRPFKRYVGLLAGLIFITAMSGGLVAGLDAGLIYNEFPYMGLGLTPPRSELWDKFYSREDDGSDLWWRNMLENPSLVQLDHRILATTAFTAVMALWAFSRGKTMSKVLPRAAKKGVHGVVGFAVLQVTLGICTLLYLVPTHLASAHQAGALALLTWTVVLGSRVWFPKQAAKILAQRAQQRASAIGVFEGNAGATRATTGAATAGPVLAASVLPAVTALALIMSNHAEGALREQLLLQRRQPGEMEMEKESEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDF8</accession>
    <name>A0A0D2BDF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236871.1">
        <property type="nucleotide sequence ID" value="XM_016378194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDF8"/>
    <dbReference type="STRING" id="91928.A0A0D2BDF8"/>
    <dbReference type="GeneID" id="27330926"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03843"/>
    <dbReference type="HOGENOM" id="CLU_076665_1_1_1"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="217" mass="23575" checksum="E9DA0F49F034CD35" modified="2015-04-29" version="1">MEPRARAGRHKTSLNFGPELSALLYAYGAPTHPDIVSPLGSASSKYLTSLPTPNTTSAPTPFNQPFPETLRVLDEILTDFIIETCHNAVSVATYSGRTKLKLSDFEFVLRKDSIKLGRVQEMFKKKRDIDNKKKLFDTNEGREGNKLGVGDLMNLGEVVGEEGTGKGKGRGRGRRKKRDREEDVTGAGAPVGGVGVDGTVEDDLDEPASKRARSEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE51</accession>
    <name>A0A0D2BE51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237479.1">
        <property type="nucleotide sequence ID" value="XM_016378802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE51"/>
    <dbReference type="STRING" id="91928.A0A0D2BE51"/>
    <dbReference type="GeneID" id="27331537"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04454"/>
    <dbReference type="HOGENOM" id="CLU_029947_1_0_1"/>
    <dbReference type="OrthoDB" id="4153890at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="3">
        <location>
            <begin position="177"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="559" mass="62467" checksum="950D0F4962B65561" modified="2015-04-29" version="1">MVGGHPEHPGDIIRRLDEPDNQLWESVEEDLFLDQRDGRSRVEVYPAHLLLPQVVEHQPLKNDGEQIGTTGNIEHGPSNDDKDKSSVQLIALSSPERVADYTRTPPKFQAFFIRQSYSWGPLLVTSELFSGLLHKARLPQHLKSFIMFFGAREREVEISPPPLAFTPLSIPGFPPDRGHQCTYGLRFVERNRHHHTSSPSKAWSLRQCAVSCRYGGKERGASWAFVTISADMQQRLDAAALAGNFRHKPDPFEVHQLLVDSAITSWRQYLLDLSGETDAHYTQILGTSPNDKGPVNLHEAGRRQDLLMLDEALLNALLAITATTDTSSALFSSWEFFVRDTSHLDPVYLDLVRRSFAHHQRSLALLSAQVTHLRTKLGGITSLLSSFLDLSSGYSLQNLALQAGEENEEMHRLAEKSTQDAAAVKVLTILTLIYLPVTVVSNFFSTSFVSSTTSADGLEKISVTGDWWILLAASVPLTLLTIYIWLVWTRIQANAHSQVWWKYMFGIHLFSRAVSDASLDSENCTARTEGTAHIEKAYSREPTDGIFAHGLRRTSSGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEY6</accession>
    <name>A0A0D2BEY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237411.1">
        <property type="nucleotide sequence ID" value="XM_016378734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEY6"/>
    <dbReference type="STRING" id="91928.A0A0D2BEY6"/>
    <dbReference type="GeneID" id="27331469"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04386"/>
    <dbReference type="HOGENOM" id="CLU_177926_1_0_1"/>
    <dbReference type="OrthoDB" id="9992270at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135:SF1">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="73" mass="8573" checksum="0414A4F43232FB82" modified="2015-04-29" version="1">MLIARRFSVTNFVIASSALAFQVFVLYPWHNKLDEDFEKLKQENTRLLAEVEKSRLQDLKEIKESFSKLRAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFS5</accession>
    <name>A0A0D2BFS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_04644</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237666.1">
        <property type="nucleotide sequence ID" value="XM_016378989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFS5"/>
    <dbReference type="STRING" id="91928.A0A0D2BFS5"/>
    <dbReference type="GeneID" id="27331727"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04644"/>
    <dbReference type="HOGENOM" id="CLU_017865_1_1_1"/>
    <dbReference type="OrthoDB" id="4109973at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="677" mass="76062" checksum="450C701303FE1BE9" modified="2015-04-29" version="1">MEIHRETPNSPKPARAKACLECRRLKMKCRPVAGNTICERCRQKSMDCIFHEKKRGRKPANARQIASRPALPSGSVADMKDVDHVRTYDSASLDQMSPGNASEDEDRDFLADSEGFQPSGLLNKQATTGAFSLKNILSTSPNVEHNTSKDTATIPEDDPVRKNIVSYHIATSLFEGFMKNLNPFICVLDPELYTFEYVRTRSPFLFAVILAASAKAFNPPLYLDLHRYAETLYGNAFCRGEKSPEIIQAFIISTYWKQPDDTRSWSVIGYAIRLCMELGFHKLVFDPKYADPETPEFEVRQRRNIERIWLLLFVYDRSMSLQTGKPWMIERSEFIESVNTWYRNPMAISNDAMMAALVTLRIASADILEAFNPQRPAPSMIQAYRFDSLLKTHSIQIEAWKKHWVEITSDRERCHPFLVSFFGTHLSLLLYSFKLQGSIASPLGASLVDTEAFWITYTSALEMLQLVSQPALTALLSFAHDSIHTMTAYAAAFLIKLLLSVNVTIRKQFENTVMKTIDQAAAIFAQQSAPPTFGCALQANFLTNVLREYKKACHRRSQPRKVAEDVTRAQAPSSGGVTDMTPNMNQAEQRQSTFLTWNEHVRPPPIATSSGRDVGDGQLRGTASANFARHRGIDISESFTGDTNTSANNLVFYNDEDWSAIFANAGFNITGGVFIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFW9</accession>
    <name>A0A0D2BFW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_04679</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237701.1">
        <property type="nucleotide sequence ID" value="XM_016379024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFW9"/>
    <dbReference type="STRING" id="91928.A0A0D2BFW9"/>
    <dbReference type="GeneID" id="27331762"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04679"/>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_1"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="378"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="550"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW17485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="701" mass="77567" checksum="AD9F1FDFACA9896C" modified="2015-04-29" version="1">MCGIFGYINYLVEKDRKFILDTLLNGLSRLEYRGYDSAGLAIDGDKRNEVFAFKEVGKVAKLRELVAESGVDMTEIFDSHAGIAHTRWATHGQPSTKNCHPIRSDPKWEFAVVHNGIITNYKELKALLEGKGFTFETETDTECIAKLAKFLYDSHPDIDFTTLGKAVIKELQGAFGMLMKSVHFPSEVIAARKGSPLVVGVKTQKKLKVDFVDVEYEGDGGALPAERANHNVALKKKAPGLLTPGGHLAPPDKSLLHRSQSRAFLSDDGMPQPAEFFLSSDASALVEHTKKVLYLEDDDIAHIHDGQLNIHRLNKDDGTSNVRAIQTIELELQEIMKGKFEHFMQKEIFEQPESVVNTMRGRLDVANKTVTLGGLRQYISTIRRCRRIIFIACGTSYHSCMAVRGVFEELTEIPIAVELASDFLDRQAPVFRDDTCVFVSQSGETADSLMALRYCLERGALTVGIVNVVGSSISMLTHCGVHINAGPEIGVASTKAYTSQFVAMVMFALSLGEDRASKAQRRAEIIEGLGKVSEQIREILQLNDSIKEMCAKFLQKQKSLLLLGRGSQHATALEGALKIKEISYLHCEAVMSGELKHGVLALVDENLPIIMILTRDDIFAKSLNAYQQVIARNGRPIVICNKDDPEFPPDKTERIQVPKTVDCLQGLLNVIPLQLIAYWLAVAEGLNVDFPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGD1</accession>
    <name>A0A0D2BGD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238229.1">
        <property type="nucleotide sequence ID" value="XM_016376659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGD1"/>
    <dbReference type="GeneID" id="27329383"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02300"/>
    <dbReference type="HOGENOM" id="CLU_263318_0_0_1"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF24">
        <property type="entry name" value="NICOTINIC ACID PLASMA MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="45"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="574"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="982"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1149"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1156"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1167"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1278" mass="142346" checksum="85D0A85266E534D6" modified="2015-04-29" version="1">MEKMVKEVSVDTATSADDHGVGTSTTIYIDPAREAAVRRKFDIYVVPVSVIYLVLSTLDRNNLGNARVFGFDEDVGLKGGQFGNIQTLSSVCTVLFEVPWVLATRRWGAKKAIGTAFILWSICTLGTAFVQTYGQTIACRMLLNAAEAGLAQAFAFLFSTIYPRELAGKRIMTTNLAQCISGAFGGLFAYAVQTMGSRHGFAAWRWLFIIEFGITVVICGVGLFFLPGEVEKAWFLDEEEKETMRLKKQRDYMIRGEEKFERKWIKVALTDPFVWLLGLAFFTSSVAINGFGVFLPTIISGLGFASLKVNYMTIPVYVLGAISLSIQVWYSDKIKKRAVFIVGCCIPVAVGYLMCVWSKNPDVGYAGMFVLVIGLYPISTLAVTWITTNLAPDTKRAIGQPFAYSLANVSNLISGQLYPTQQGPRYIPGNAISAGLTIVAGFLYASCWFLLRRRNAQKAKLIAEGATTNDVIVVDGLRRSALESHANVAFASSVDANSRTWGVQEGQSQGPVVPGKSFDLALQRRVQGSCISTSRSVEDDVAEQFRKRATYLECILKHYAPELDFGTESLRQKAHSLVSEEADPTQAAEGSPSSASNGDITIQDESCTINAVNENIAHYSGEFSYWNFSMRLNNQVKDLMVSHHKTISAKLQDIPHYWRVEQLGSGSPAVSEASSNLPPLQIAQFLVHIFLKHAMSNYYYFDSQWLSEKLSLTYGQSQELASKDAGVLAIILGVLAVGTQYAHLDSPRGASGKISSQRHSDDELGAAFYQQAVRMLPEVIHLGSVESVQGCLLFGLYALPIDASGIGYIYLNLAIKFAMQNGMHRRAPEHIFSREILDRRNKLWWTVYCLEKKISIYHGRPISIRPSDIDADLPCADTEAEAISETMSEASSLLIMIKLMDYLGKFADDISMLRTSPRSQTPGILSRLISKRDKLKLWWDTLSLRKRPLSRPNIHLQLEICLLRMFIGRPFLAGRDVPGLTPNFGSEEPRVPRKSPNTTDNRWEQQSRRKSRTSTLVDDCVAAATEAIDLCQNLRDNGGGLATMSYTEYSSCRASLLVLIAFCIRTQTIQYYNHQQRGLEMIRDMAAAGESARHEVLLIEALGRAVKRLHQLHLKMQSHNTSHQRPEVDYDRFKQWGAAWKAGRSTEELERRQGQVGLSNNQSQSTDRMDREDRDSRDATYDADSATNNLRHGPAHVPSNVSDFFAPDELPAVMDHGFFNWDSAFPGPNSFYEQSERQLLENFLSIPEDEFQFSTVFDSGQHMAAFSTINPGQNQEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGD2</accession>
    <name>A0A0D2BGD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230630.1">
        <property type="nucleotide sequence ID" value="XM_016385686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGD2"/>
    <dbReference type="GeneID" id="27338460"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11377"/>
    <dbReference type="HOGENOM" id="CLU_1461338_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="185" mass="20570" checksum="665DAD9043BBCE35" modified="2015-04-29" version="1">MGAAPDQGHTKKSTEKPEWNGSNGNSSQLLPYDSTSIVNLINTQSLFILTTSLLQQQWRWYPGPRIRVLPARTLLPRGSTQSNPGDVLADLGTPFRGSHGPEEDRDAVSEPLPSFKAGRIVCVDLEAALDLVTSRTCYSKPGRLDRTACGMFDKYDKQIEEKRKDGRDVRRICERETDSHEGAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHB5</accession>
    <name>A0A0D2BHB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW17995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238211.1">
        <property type="nucleotide sequence ID" value="XM_016376641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHB5"/>
    <dbReference type="STRING" id="91928.A0A0D2BHB5"/>
    <dbReference type="GeneID" id="27329364"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02281"/>
    <dbReference type="HOGENOM" id="CLU_010194_13_1_1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32698" checksum="FD2977E893A13055" modified="2015-04-29" version="1">MASIKLDGAILTKLDSKVVVLTGGSSGIGAATVQAFLSRGCRVVFGDIDKAAGQLKVSQLTTRDKSIVNQLKFVPTDVTNYDDVYHLFQVAYETFGRVDVAANIAGIVETPGWFDPAETMEGAKRKPSTIVIDVNLNGSLYFSRIASAFLRQGQESTDDKSLILISSVAGFKAHSGIFLYQAAKHGVIGLMRSLRSFKPIASKIRINCVCPSMTLTGMVEGIKEAWTSAGLPINTPEDVARMIVHIAADSELSGGAVYVEGGNGWEIEQRLDKTQPLWLGERLSKQLNQSVIALSTIYNPIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHC5</accession>
    <name>A0A0D2BHC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230965.1">
        <property type="nucleotide sequence ID" value="XM_016384363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHC5"/>
    <dbReference type="GeneID" id="27337131"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10048"/>
    <dbReference type="HOGENOM" id="CLU_043546_0_0_1"/>
    <dbReference type="OrthoDB" id="4117575at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="493" mass="55775" checksum="50EA678397A86027" modified="2015-04-29" version="1">MASSLGAFNLSRSYNPPLIAQEISCTYPISDVYGPTPRYVYYACLFLSFLTPRYGWLAHAILGVAVAYAATAAVQAFILLSARLVPAPVQNVTIPYVPGTNLTGYFAGIDALVTNTDYVKIQPDYLELDIDAVTSVVITAYLVGLPLQCWSRITRASTALHRLVLAWNLVMLAASISVLILWPHLNVAPAQYRFCYANVDDGDSFQNNNGWDSDYWDQTWNQTVWRLFGQPILDNALWFNYTSNCMYPCFSTSQILRQASSLRASAFTPNAPGARLHTDDGYSKDDFQPLIYTAITCFTAAQLFLLAMGRLKLCTRRVPIYEPRQIWARRKEIWRSFDDDFKRGWAHLTNILRSPLKALRTLHLPRQRNITTPIRQHPLFLFSIDLLVMLVLIAAMLLGPLTVIAFIIWIERYIHQDGTPTESPQAVGQWGIAVELGVVLVAACVLRLKHRIASEEEIRREIEHRTVELDKLRCIADSKRSDALPRTEEQQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHM1</accession>
    <name>A0A0D2BHM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_10168</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231085.1">
        <property type="nucleotide sequence ID" value="XM_016384483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHM1"/>
    <dbReference type="STRING" id="91928.A0A0D2BHM1"/>
    <dbReference type="GeneID" id="27337251"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10168"/>
    <dbReference type="HOGENOM" id="CLU_035750_7_1_1"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW10869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="283" mass="31005" checksum="A49B7653FF310319" modified="2015-04-29" version="1">MDSLVAQYTQSPFPNEGLDAEEQLDYSDSTPSLSLKFALPPVPRPSAFLRATTDDYSNPNCPIKIAHGTTTLAFRFKGGIIVATDSRATAGNWIASQTVKKVIEINPMLLGTMAGGAADCQYWLAYLGIQCRLHELRHKRRISVAAASKILANLVYSYKGMGLSMGTMITGVTPEEGPALYYIDSDGTRLSGNLFCVGSGQTFAYGVLDALYKYDLEDDEALELGRRSILAATHRDAYSGGYINLYHVKEDGWVKHGFSDTNPIFWQTKLEKGEFSNVTSELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIJ3</accession>
    <name>A0A0D2BIJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238626.1">
        <property type="nucleotide sequence ID" value="XM_016377056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIJ3"/>
    <dbReference type="STRING" id="91928.A0A0D2BIJ3"/>
    <dbReference type="GeneID" id="27329781"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02698"/>
    <dbReference type="HOGENOM" id="CLU_1525171_0_0_1"/>
    <dbReference type="OrthoDB" id="4153420at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="176" mass="19612" checksum="1E37A8A357B50784" modified="2015-04-29" version="1">MEARTSLIQEFYGCLVLLRLLTPNRSRAISDRSVDPAVPRRNEWHVFLDSLAWLADHKGAGETVTSIAVEPSPARPTYWVASNSYIKPEALQHVNSVLSALQQETSLDRSSSRELIRKIARDSIEFSGLHVREYCRKLKSTIAAIDATEPIVLLGNGIGPIRLFCGLLLIMLIAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJH7</accession>
    <name>A0A0D2BJH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238976.1">
        <property type="nucleotide sequence ID" value="XM_016377406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJH7"/>
    <dbReference type="STRING" id="91928.A0A0D2BJH7"/>
    <dbReference type="GeneID" id="27330132"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03049"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="31"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="123"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="38720" checksum="BBCC531FD1D7E7F8" modified="2015-04-29" version="1">MSTSTTPFQTPPPLPPGKSQHHIVVLEGIHADMPPFDFPHTMTVHQRSTPAQVSERIRDATIVVACVVPVTPADMDSAPHLGCLAVMAVGIHWVDKADCARRGVTVTKCPAGNVDAVSEHFLGLYFAVRRRVVQVHSKVTRSDEWREKGTLTKLWPGGPPMGCRQEVLGIMGYGTLGKRIAQLARAVGFGDVLISERKNAAAVRDGRVSFDDVVERATVVCVCVPKEDDTVDLIAESELRAMRKDALVINVARGGIVNERALATALRQGWIAGAATDVLEVEPAGVGSGPLTPDVSKGEEEVPNLTITSHIAWFTQTTIETYRRLLKEGIEGWASGTLQESPDKVNKVVVVHNGKVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKL0</accession>
    <name>A0A0D2BKL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M6-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239326.1">
        <property type="nucleotide sequence ID" value="XM_016377756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKL0"/>
    <dbReference type="STRING" id="91928.A0A0D2BKL0"/>
    <dbReference type="GeneID" id="27330485"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03402"/>
    <dbReference type="HOGENOM" id="CLU_035035_0_0_1"/>
    <dbReference type="OrthoDB" id="4149534at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775:SF1">
        <property type="entry name" value="PEPTIDASE M6-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M6-like" evidence="2">
        <location>
            <begin position="106"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="489" mass="52971" checksum="6B06C57D68E06355" modified="2015-04-29" version="1">MCFGSNSDPHGPCLVSPHPRVLAGTSGGERDALRKQIPGRLPPGGPTGTLHGLNDGTIFPESHYRRVPVPSSARMSRAALERTPLRGPIRVVIVLVDFSDKPMTTSRQHFEDLFFSKGKIPTGSVTEYYEDVSGGKVSFTGEAIGPFRMPLTLAQYAHNASGMVEEAPNLQDLAAHALAAVDGSIDLTPYDNDHNGEVDAFIVVHAGKGAEELPAGPERDGNIWSAKWVLRNETRADGTNVFGFLTVPEFAYIGVCAHELGHLVFGWPDLYDIDGDGDPENVGVHSAGVGDWCLMGGGSWGHLPGNEPGTTPCQPSAWCKANQGWINLVVDQQNRTISLKDVKKEPREVHRLWTNGDTISQEYFLIENRQKTGFDRSLPGQGLLVWHIDDQKENNRDERHYKVGLVQSDNRRQLEAAEGGPTGNRGDAGDPYPGTAHNTSFGAFTSPNSRTYGGRDSKVSIKNISAPSQTMTMDVAVRSTFPVAVGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKN7</accession>
    <name>A0A0D2BKN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_03437</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239361.1">
        <property type="nucleotide sequence ID" value="XM_016377791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKN7"/>
    <dbReference type="STRING" id="91928.A0A0D2BKN7"/>
    <dbReference type="GeneID" id="27330520"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03437"/>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="9">
        <location>
            <begin position="379"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="703" mass="75876" checksum="5557A5655F31753C" modified="2015-04-29" version="1">MPSITNGHSATVNGASAPSVLTDDEQAVRDLRKFIIDICRQNGGGHGGSAIGMAPLGVALWRHTMRYNPKNADWFDRDRFVLSNGHAAMFIYTMLHATGYPNMTLDEVKLYGSAKAVDPETGKWTATLCHGHPELDVPGIEVTTGPLGQGVANAVGLAIASKHLAATFNKPGYDIVRSRIYCTTGDGCLQEGVAQETMALAGHLQLDNLVLCYDNNQVTCDGPLEWIVSEDTNAKMRAIGWNVIDVFTGDSSVDDIVSALKLARSTKGKPTFINIRTTIGYGTSTAGTFKSHHGTYTDADAALYASADVPSTHTLSEQTKAYLAGCVAKGQTFEKDWNDLLVAYNKAYPTEAQLLSDRMNGKVDYETALSSIQVPKITQATREFNGTVFNTLMSHVPHLIAGGADLWNSNQMGDQTSRIYSGGHPEGRVIRYGIREHAMASISNGLAAYSPGAIIPITATFFMFYLYAAPGVRMGALSHLKVVHVATHDSIGEGQNGPTHQPVELDSLYRAMPHLAYIRPSDAEEVIGAWSAALGPATKDMSVIISLARDPALTAIPNTDRANVARGGYVIVERSDAVVTLVSCGSELQFAVAAAKQLTEQHNIVTRVVSMPCISLFEAQTETYQNEVLGVTKHVVSIEAYVSSMWARFCTASVAMDDFGYSGLGIENFRRFGIDDVGIVKKVKNLLQISTSGKGRTRWRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLJ7</accession>
    <name>A0A0D2BLJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232255.1">
        <property type="nucleotide sequence ID" value="XM_016383632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLJ7"/>
    <dbReference type="GeneID" id="27336396"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09313"/>
    <dbReference type="HOGENOM" id="CLU_040660_0_1_1"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38593" checksum="26E4BD7952175F6E" modified="2015-04-29" version="1">MAPSVSSLASWRTLAIVLALINLKCLPLAWHLRLAYRFVRNSFTPAKVQRAIKASADSDKIYPLFGYVSIFSRAPLLETDYNLHKSNSTYFTDLDESRMALMARILMPNRDKGIKALEEQEHKGRSAVILGSVHTSFHREIKPYERYEVRSRVLGWDKKWFVIASYFVRPATKGKQEVVLASALSKYVVKKGRFTVSPERCLMTAGWLPEKPETYQSGAGQSVESSGGSSSDTPTTTVVSDSHSAAATLQEDPSEMATPVPQGLLPAPVPATPVVEATSTVVDKLEKAAQKVSDELLPASEPLMPLTKVDHAGEWDWHRIEMERIRGLRVAANWLALDKNLLDEASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLT7</accession>
    <name>A0A0D2BLT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239721.1">
        <property type="nucleotide sequence ID" value="XM_016374445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLT7"/>
    <dbReference type="STRING" id="91928.A0A0D2BLT7"/>
    <dbReference type="GeneID" id="27327160"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00077"/>
    <dbReference type="HOGENOM" id="CLU_020880_3_1_1"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000065">
        <property type="entry name" value="Similar to histidine acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF14">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="59"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="411"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="51685" checksum="6C924F3BE7FDE082" modified="2015-04-29" version="1">MTLTQYFVVVILKLSLAAVAFSPSLYDTYNFNPLEHLAGIAPYFEPNDPPRNPNPPDGCTVTKAAYLVRHAAINANDFDYESYMEPFLTKLKNHTNINWGGLPSLAFLSTWAPPSFAEQEHVTRVGKLEAAQLGVEVSFRYPNFRAPRNVWASTAQRTVVSAESFIRGYETADNNISLVQIYESEEGGANTLTPYDSCPVYSSSAGSEQSQRYLSKWTKPYLSRLNHVFSSFNFTADDMVGMMELCGYETVIRGSSPFCSLDLFPPDAWLSFEYTNDLMYFYNTGYGQPVGGYIGFPWVNATMGLLSSDGASSPQDLYVSFTHREFPPTVLVALGLFNNTDFIGGNPNDSMPLDRINYNRAWVSSYILPFLTNVAIERMNCSARTSTYGDGGSSPYYRVLVNNSPQTLPGCNDGPNESCSSEGLSNWLAERAAMFHGFSAACNTGADYKNSTDMVTFYENGGNGSFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLW2</accession>
    <name>A0A0D2BLW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240149.1">
        <property type="nucleotide sequence ID" value="XM_016374873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLW2"/>
    <dbReference type="STRING" id="91928.A0A0D2BLW2"/>
    <dbReference type="GeneID" id="27327591"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00508"/>
    <dbReference type="HOGENOM" id="CLU_034666_0_0_1"/>
    <dbReference type="OrthoDB" id="3197614at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130:SF1">
        <property type="entry name" value="SPINDLE POLE BODY-ASSOCIATED PROTEIN CUT12 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="475"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="561" mass="60276" checksum="63BFCF6D89E981B4" modified="2015-04-29" version="1">MDAAPLTLAHTHARNAALEHKRNNPVAASEEYDLAAAEFAAAARDSTDLEARRLLSLMEAQHRKLGEILRTSHERSQEKRSVGETSRAATATDTLPARTPSAEPARPPSPENTVRPPRLPRGLRPNARDLSSSIASNLASARGIPSTRQKRPTPISPLVSAQNADGQIAQEDTTARAISRQNSSPTISDLASRPPWAPPVQPEPVATPKEQIDQHAADAPFQQFYSTFESLISKLSAPLAFAGLPLTSSPTPAPKATTNKPPAQVSPKTPSHYSAPAAPSIDYSQLISRAALRAVSGAPSINPSESFYVVPTTGGTISYAEIMNRAEREEGRVLRHHAHSRQTSNLSNISEDDFVDAQSTILPTTGPPSRFTRHRGAGGPSSDNTEAKVNGKTMEELALENQALKHLSDTLSKRLHVFEMSSQTASAAMAQSIRSLHVGRSSPLMSPENSRGRVTSGKGEAFAASAADDVLAKRIADLEDILRRSDARAKKKDEENAKLKETITKYREKWDSLKAGAKARRERERETRAATAVTATARSDEKSQDAPSVEASSNVKGGEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLY6</accession>
    <name>A0A0D2BLY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239806.1">
        <property type="nucleotide sequence ID" value="XM_016374530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLY6"/>
    <dbReference type="GeneID" id="27327246"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00163"/>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="546" mass="59607" checksum="CC46364E695BEFA8" modified="2015-04-29" version="1">MKLTRKKSNPCIDDTFPTTQFLILAICRLSEPIAITAIFPYAWLMVKSFGLGDASFYAGILIASFSLAEALTSMFWGALSDRLGRKPILLTGLAGTVVSLLVVGFSTNFTVALCGRIIGGALNGNIGVIQTMVGELVTKPEHEPKAYAVMPFVWSIGCIIGPAIGGLLANPAKSYPGVFPSTGLFGHFPWLLPNLICAVIMLFSIIVGFFWLRETHPEFRQRGPEEDSRFNVTEHTPMMLTAGANADAGTDLRRDSFGTFNEVEIQNNLRWKIGAHGSSRSFSISEKESQKWLTKRVAMLTLALSLYTYHSMCYDHLLPIFFEDKPVDQVFVSRVTAFHVPGGLGMSTKDVGVIMSVNGLIALFIQAVVFPLAAERLGVWRVFVLVTIFHPVAFFVVPYLALLPRSLLYPGIYFCLTIRNLLSILDYPVLLILLKQASPSLSTLGRINGLAAAAGAACRTIAPPVAGLLYERGSQIGFTGLAYFGAGAVAIVGVVQLWFVPREKYTSTVKPIIPYMESTEDAIRDVVDVTVVDDVEGEDEEENDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMC4</accession>
    <name>A0A0D2BMC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239961.1">
        <property type="nucleotide sequence ID" value="XM_016374685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMC4"/>
    <dbReference type="STRING" id="91928.A0A0D2BMC4"/>
    <dbReference type="GeneID" id="27327402"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00319"/>
    <dbReference type="HOGENOM" id="CLU_024511_1_0_1"/>
    <dbReference type="OrthoDB" id="2417614at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF2">
        <property type="entry name" value="BACTERIOPHAGE T5 ORF172 DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="370"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="507" mass="56845" checksum="9C1816A1AC13EE16" modified="2015-04-29" version="1">MSFSGRTPESLLPRSDSKNPATTCRGITSTGRPCRRALAASPKTSPAPSPMRGVGVLAVLDEQNAAAFYCWQHKDQAEELAATQQPKTTLYPLKEKSSIDTLVERVGILDLDESVPERKRHRRRHEPHNDRPTRRETLPARWSDMQSPIMKVPENMVYRSHHTRPPPPPPPPRSNVKLSWACCIQAADDDDDDGYPPPRTRRPQERNRPSRPPHPSSGGNGYVYTRPSMRPEQPAPAPARPSMTQRQDMPRPLHNLQSSATSPRPTLTSSLPSKTHSETGALLSLIPSTLSPQTTSLLLTELSRPISPADETGYIYIFWLTPTSETSKPDDEAASSLLDDDDHNAGPSARSTQALQRYASVRRRGPQGRVRRTMMLKIGRAENVHRRMTQWTKQCGQNITLVRYYPYTPGRASPQAPSAVADPRSSGLGLRQGQGEREADNRKVPHVHRVERLIHLELAEKRVVKAECEACGRMHQEWFEIEATRAGLKGVDEVIRRWVGWAERQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMI6</accession>
    <name>A0A0D2BMI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232595.1">
        <property type="nucleotide sequence ID" value="XM_016383972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMI6"/>
    <dbReference type="STRING" id="91928.A0A0D2BMI6"/>
    <dbReference type="GeneID" id="27336739"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09656"/>
    <dbReference type="HOGENOM" id="CLU_002639_4_4_1"/>
    <dbReference type="OrthoDB" id="5135333at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="260"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="736" mass="82196" checksum="AA38C5FC53A73517" modified="2015-04-29" version="1">MYRLRETSSVSALGVIANPANIFKDPSFQVSIPYRKPQQTGETLVGGPYGSKACTKDDKGKVCLRCWRWSLTGVRDTRKLVEGSGGHQNSLLGKHWGYPAEMLDADCPMCRLFGMHSEDFQSINGPMQGRRYDLRELTFTVKLPQSRSSGHLATTAKFWYLVPSSAPRSNFAQLAGSGSCIGLADGRDGSAASPSDHLMPVLIDPNTINYNTIETWLALCDRNHRGTCDFLPTETVPHLRLIDCLALPPKLVDAMPRRKYAALSYVWGRGGVKEQLEGDTVVWRLLPQTIRDAMTVTRKLGLRYLWVDRYCIPPPLLQEQISKMDVIYSGAELVIVAAAGGDIEYGLPGVGARKRTQQPYATVGKDVFASTLTDFDSMMHTCSWWKRAWCFQEALLSRRRLIFTDEKVYFLCRNMLCVETLSIPFEDPSHRPRTRMDSSTGFFDWLVTGGSSRENPDQIRAILSAYSGKGMSFESDGLNAIAGVLRAFARVDKRGLEFRSYGGLAITGPPTTNSFVSALLWAHWIPRGRRPGGFPSWSWVGWTGSFRASSISREVDHEMEALLLEGDGTTTVSWEGFVARSRPDDGIFPLSLYIRLHALTCMVQVCYRPSAGKDQRYVVPVQRLPGGKVRYATVSLGYACSDTGGLDDDDLHVALVQRPQKCVLLVPHDDARKLSGIALLVRKVGDEHYERTGMFQFEYFGNVYDEMGNYDSFLLSTDERAAVEGFDFQREWICLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMQ7</accession>
    <name>A0A0D2BMQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240071.1">
        <property type="nucleotide sequence ID" value="XM_016374795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMQ7"/>
    <dbReference type="GeneID" id="27327513"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00430"/>
    <dbReference type="HOGENOM" id="CLU_657262_0_0_1"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="418" mass="46815" checksum="C75A32AD04CCD9D7" modified="2015-04-29" version="1">MEGTSRIKNRGKGQSHPGTPRSKATKALLHPDSDPEQLLQQSVGRLCSSPPSHLSSKDQALLKHYVHHVSGLLSSTDDRTINTYCNTILRMAWDSNLLMNTLLLVSASHLAGRSEQTALDVPHYRHRVLPELRAYVANWQGFDKIILATIIMMSINEVFEANPDTWVTHLKAVSQIISRNLPQWKTCDQETRMLLDIFAYHSVLALIGTNQSSLFMDYYRGDTWSALKGHRGAFLAAADQIISFVAKLSELFPASPADGPPEPIEPSRLARARSLKADMEHWDPPREISSDACNTAQSMRYAGLLYYHKLTSSSLTECDREEILSYCRAIVRHIGQVSLDSPSAASHTWPLYMAGSFLNSRTGIADQETQDFIKERLAALKLRRGVRTIDSVRDRLELVWKSDGTDLAVLDAPLILLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP55</accession>
    <name>A0A0D2BP55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="10" type="ORF">PV08_08071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233100.1">
        <property type="nucleotide sequence ID" value="XM_016382397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP55"/>
    <dbReference type="STRING" id="91928.A0A0D2BP55"/>
    <dbReference type="GeneID" id="27335154"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08071"/>
    <dbReference type="HOGENOM" id="CLU_032354_1_0_1"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="104"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW12884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="279" mass="30606" checksum="295D64F734472E1E" modified="2015-04-29" version="1">MAPITDDVVSNLKDQVHKLEARIWELEQRLESGSSKQSKADSMRLILMGPPGAGKSPTTSGTQAPRIKDKYCICHLATGDMLRAQVAKKTALGREAKKIMDQGGLVSDDIMINMIKSELETNRECANGFILDGFPRTVAQAEGLDKMLESEQKPLKHAIELQIDDGLLVSRITGRLVHPASGRSYHKVFNPPKEAMKDDITGEPLIQRTDDNAETLKKRLGTYHQQTTPVVGYYKTKGIWAGIDASQDPEHVWKSILGVFGDSKGASGSSILNKIGLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ30</accession>
    <name>A0A0D2BQ30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233455.1">
        <property type="nucleotide sequence ID" value="XM_016382752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ30"/>
    <dbReference type="GeneID" id="27335509"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08426"/>
    <dbReference type="HOGENOM" id="CLU_365634_0_0_1"/>
    <dbReference type="OrthoDB" id="4155977at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="767" mass="84347" checksum="5F13DC853BDBF9B5" modified="2015-04-29" version="1">MESSPVSVPSAKSSSKSSNSSRVPGTPKPPFEPPRRRSSLFFTKVLQHASSPRTPGSTLTRAIGKDNPEMPGPNIGRKRMASPRTRSAAMPGHVAQMQRLFQTAKASLRFDVRFAASATGSIDSRLPSSPETGHYAIGSPSQSDEALMETPKTDWRYSTAPKLVAELDLDVREPFPEGSPQLPQLPRVDLHQGRPVAMEPPSSGFTSPVANPVQNENVVPSPHADTDRSDDENRCIPHEEYLSPDDLERPMTHLQVSSDNEMNVDGTEESPIICHLKRKSADVQVTVECSSDSTGSILLPPSAKAAADSARLRRGMLSSRFPKPQTTEGDDDDDDDDDASSSNSSKSAVTPCPDPLLHERTPMVLCPDPGMHFSSSPESPSHRSHPRNKDRQYHRSHHQHHLVSNPPKSFNRTTATGSPMPALRMKPAHKAPAGLRRPPYDNRHPNSTLLQPPRHPLRPHLPPRDYLSGATEHFQPGWYYARDSPDLLTKPGTAMYSFSTAAGKVSGHDAAPDSMIRDSYRTDTLTPLARPPSRFRKHGVAAIATARGVSKYYGRSYGPRPSLHQKRSNGTRLPDEVRFRSSPPRSTTDSDQAYPTQPRQRSRELEGPSIEVPASISTEAVSMDPRLKLEDGEDIIEIDEETRAAVRMSLYGGTTIDPHGSDASRGLKDLSPNVMQWRKGHRPPKSRRKRRPSYWDTDLKEVMRSPAARHVVSSPIKEADMRSQKGEVGCQNDDVGEENETGLGILEGIPMPARKNIDLQGDIAMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ86</accession>
    <name>A0A0D2BQ86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PV08_01237</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Small subunit of the arginine-specific carbamoyl phosphate synthase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, the first step of the arginine biosynthetic pathway. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240876.1">
        <property type="nucleotide sequence ID" value="XM_016375600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ86"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ86"/>
    <dbReference type="GeneID" id="27328320"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01237"/>
    <dbReference type="HOGENOM" id="CLU_035901_1_0_1"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF4">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="18">
        <location>
            <begin position="57"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KIW20660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="477" mass="52297" checksum="20CE78979DAD9283" modified="2015-04-29" version="1">MFSRLLKPSGLVPKTGNIISSSSALRARSLATVSNNTPRQQDLPLHKQYKHTAPAHERATFTIRNGPIFHGTSFGARSNVSGEAVFTTSLVGYPESLTDPSYRGQILVFTQPLIGNYGVPSNVRDEHGLLKYFESPNIQAVGVVVADVAEKYSHWTAVESLSEWCAREGVPAITGVDTRAIVTYLREQGSSLARITIGEEYDQDEDEAFVDPEQINLVRKVSTKAPFHVSAANPTAHIAVLDCGVKENILRSLVSRGASVTCFPFDYPIHKVAHHFDGIFISNGPGDPTHCQDTVYHLRKLMETSQLPIFGICLGHQLLALAAGARTIKLKYGNRAHNIPALDLTTGKCHITSQNHGYAVDASTLPKDWKPYFTNLNDNSNEGLIHESRPIFSTQFHPEAKGGPLDSSYLFDMYLDNVQKYKQGQAAFQPTRDSKPSPLLVDLLAKERVGVDLTQGIRNMMASTSQEPERVYAAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQB6</accession>
    <name>A0A0D2BQB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_01723</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241359.1">
        <property type="nucleotide sequence ID" value="XM_016376083.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BQB6"/>
    <dbReference type="GeneID" id="27328806"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01723"/>
    <dbReference type="HOGENOM" id="CLU_001442_8_0_1"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000024">
        <property type="entry name" value="Putative jumonji family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055500">
        <property type="entry name" value="DUF7072"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23258">
        <property type="entry name" value="DUF7072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="384"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="631"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="865"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="994"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1148"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1226"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1251"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1148"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1175"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1262"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1313"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1323"/>
            <end position="1342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW21143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1512" mass="168840" checksum="53E9BF45D3DC0541" modified="2015-04-29" version="1">MAATTMSSLPPHEGLGDTAPDKRDSIADPVLPPQVHTPPTTDEASHKDDDAASSSSLSDLGDDMEDEENRIRFEEAARAGAEAEQFSEVKPDRYENGVPIFTPTMEQFKDFQRYVKGVDPYGMQSGIVLIDPPEEWKRARKALDDMVKTIKIKNPIMQEFHGAQGIYTQRNIEKMRSYNLPQWKSTCEQTENQPPARRGEKRLNADKLLGRGNTRSRKAESAAPPESGKRRGRPPKQIKQEPVEHDSTLHAPPTPTSPDVKPAVTMSEEPEEGREDTAEPTPTKGKSTKKPGRPRGRPPKSSAPKKESAGSKGAETTVAARRLRNAREANDDIDEEAFKDFDYRVYDNDQWTAERCDELEDKYWKSLNFSNPMYAADMPGSLFDEDTKEWNVAKLPNLLDLLGQPIPGVNTAYLYLGMWRATFAWHLEDVDLYSINYIHFGAPKQWYSISQKDAPKFEAAMKSLWGSDAKNCDQFLRHKTYLVSPSILKSKFGVTVNKVVHREGQFVITFPIGYHSGYNLGYNCAESVNFAIENWLQYGKTARKCQCEADSVFIDVDWFIRRLNGEPSPEFEEVEVTDDEDELDDTADLPTPPASDRGKMKLPQKRKRGPKDLGPNKKAKKLIKIRKVSKNQPCCLCPNDFVWEELLPTSHGQKAHRTCAMYTPETYIAKKGGKEIVYNVENISKARLELKCYECRQKKGSCFQCSSAKCTKSYHATCAMQAGVQVDKGEIAVWHEGVEYRDIGFDWRCRLHRTVKRTRITSELSACNHANSCRQNPEFREFLSKLNEGELIQFQATNSDDIEAGLVIAGYDSGQDSLLVKVLPDLKTVKEVDPSAILFVDSATSCLQRPSSNALDLPETLQGKAASFPESTEKKPSAGDVFTEEPRTEWAEFVSAEPPVNMDQKLVDISKEKQLWLYLGDISSDAKPHYTADPDRHVHDPASNFLDLVTPRKSAMAPPPQPKRQSLSASHPMVNVAARNAAMASMRQSAANSRAASPAIPGTFSGTTQNLTMNRGPETSNVPRTGQVKHSQSRDMMTGHEARLNEQARILQRQQAKALQLDAAEKANTIGHASIGIDHEAVQRQRQFQQQASQHAKHMKEWSNDPSLPPLKQYEQFPSFTSFDNSGNYESPSMMSAGFRPQQFQYSNDWMNADSPSGRSNYHGSQSMNLSSMLSPQPHQYQSSSSSAAPFPAYVQQSHLDFPYSSQTRSSNTTPGPYQSTSLETIRAAASQPPPPPPSAEVERRRRISNPAYPFKSPDQIKAQKEAEKRSPPGSRPTSSYMLPSPRIQHDTYMHSASPTGPMQPLDPHNPPQFVNPNATQISPPASSAGHRSARGSFSGFGTQPIIGPSLPAGVRRSFSMDMTLPDMAPFPAASLPFSGYVPRRSIYDPLSQVNAFQQVKPKPSEPPMAPMSSKLTETLEKRAMGANGLPLNDRAVPKQLLDWRDRGGFWSRVSSYYISKHQATATIYRSPFMAMTQQTDNVSLSDRYYQSLEGDQQSKIDAFRQGKQRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQK9</accession>
    <name>A0A0D2BQK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240981.1">
        <property type="nucleotide sequence ID" value="XM_016375705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQK9"/>
    <dbReference type="GeneID" id="27328426"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01343"/>
    <dbReference type="HOGENOM" id="CLU_052827_4_0_1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="126"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="221" mass="24541" checksum="1BDFB6426281E663" modified="2015-04-29" version="1">MGQQMDFMDKFIAAHDVPKEALAHFAANDFTSKYLSNPVYRPIPTYSRVLKDDGEDYFFSRTVATPTTIPYLVTLQLKDFPIAEESPKGTLKTGQGHKAVVKVPENPDCIMLLHLGRPGVDGHPTTLHGGVACAILDEMMGLCVMLHHRHLEGARESLYTAGLNVTYRAPVPTPNDVIVKCWLEGREGRKWKSRGQIVNKDGLVMTEAEGLWVLAKNEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR17</accession>
    <name>A0A0D2BR17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241111.1">
        <property type="nucleotide sequence ID" value="XM_016375835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR17"/>
    <dbReference type="STRING" id="91928.A0A0D2BR17"/>
    <dbReference type="GeneID" id="27328557"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01474"/>
    <dbReference type="HOGENOM" id="CLU_2372827_0_0_1"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="95" mass="10750" checksum="CF9F093B141EB3FA" modified="2015-04-29" version="1">MLLQDPRLPELFERYPLLRQKLKSIFETTAEENSEISSNARHHGQPKAAKPPAQRIVRSLQNLEKELSSDNAERIGLKAFADLVVAVNSNQARKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR44</accession>
    <name>A0A0D2BR44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233910.1">
        <property type="nucleotide sequence ID" value="XM_016383207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR44"/>
    <dbReference type="STRING" id="91928.A0A0D2BR44"/>
    <dbReference type="GeneID" id="27335968"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08885"/>
    <dbReference type="HOGENOM" id="CLU_006237_0_0_1"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="876" mass="98627" checksum="0E153431DFEF4675" modified="2015-04-29" version="1">MATVTCAPKTMLNSNAKPRRRQNHCCDQCRRGKRACDATGRDSNEVCSNCIRTGKVCTFEKVLRTVKEKSHRPGEKSASAPSVSQADTRKSVSAAPDASLSDTFQNSVHTLSYRSISPPSLDAVDFSGFDAPPQERANSQDSTAFPDFNELCPSLTSEDFELITQDDMNGSSAILGWDSSHTYHQRDVGSDNQTTPSSIFSFGEDLYSNSSSTNSRKRKTPPQGQRSPKLKSRNYTNPFSDVTIATLAERTNKAIISESLTRIYQDTMENAMSCWITERTCPYIYEGLELSKTRTLEYLTGESFLKSGNRMIARICQLDRPTSTLRERPLTPHENNLSSRALKATIMAFASQWAQSASAVKQSTGHTPRFEALHDIIDGRPNSSLDGRDSSNFDRSLQESLWYDARKALHEAAEIDSFRVMFAQLIFSFIQKPLPRHQYAMIMKHKAKRGLKREPSVISNADIMSINSQDSGIKSSEIRPDHAVSDISRESQELQDLLDLQGRPVHIEAALLRLSTKRVHLEGSSRNLRQDLTDKMAITDRKSFNMLFWVTMMCDTIMAVFYNRPPVVSDEDSLILQVDPSTDPQSSITLGDPSTDNDIESSPWGTLLMKKAECTVHTTRSAWPFSEEHALALLADAAQVKVLLYRKIKRLSNCIFRRNSTKTIEAAIVDALNVYEYWNKAYGNFIIDCVRHHDELHPRVQSWYSVLIGHWHLGVLWLADCLDDVDQHERGDHLYGALRKSCRLTFEMRRTSAFQMADVCRVARPRNGSSFHQISDFHTTVSQGALLTEPWTEILIRCFARSADWFMVWLSELQSNSLPLASFGFDTLYENCAQCIGGLFDIGRKSDMSYLAALSLSHRLQNAFPNAPRVDDLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSC3</accession>
    <name>A0A0D2BSC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribose-phosphate pyrophosphokinase 1</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphoribosyl pyrophosphate synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PV08_06905</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234340.1">
        <property type="nucleotide sequence ID" value="XM_016381238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSC3"/>
    <dbReference type="STRING" id="91928.A0A0D2BSC3"/>
    <dbReference type="GeneID" id="27333988"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06905"/>
    <dbReference type="HOGENOM" id="CLU_033546_1_2_1"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000017">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000043">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="18">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="227"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KIW14124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="542" mass="59237" checksum="E4FEA80D51A51465" modified="2015-04-29" version="1">MRGVKVFSGRSHPTLVQSICERLGTSPANVDLGNFANGEISVQIGTSVRNEDVFIVQSGSRNINDSVMEMLIMIAACKGGSAKSITAVIPYFPYSRQSKKKSHRGAITAKMLANLMVVAGVDHVITVDLHASQMQGFFGKPVDNLFAEPIIARWIKSNVPRWQKAVVVSKNVGGTKRVTSLADALKLSFALVSTDRDRSKPSHHHNNMMDSTIFFDAIEPQSLRLEHRQNDGEDGEEADSILEDPFQDTTRRGPLPHRKKSSANKSGTNRLGRPKAVTITSSPLIQSTRVESSPAPETPDELTRADTAPSARRPSEYEPSEALHDERVRDVRVGRLIQGHLVDDDHLSSAVSSSASVSGGHGDRSSQILQDGPDGFGYDPMTASFVSTTSSFQPEHALGGTFDAAATSDEEEEQIRNPDLEHTITLVGDVRDKTVILMDDIIDKSGSWIAAAETCVKIGSAKKVYCVAVHALFGDDSLEELEECDYIDYIVVTNTFPISPERMRSSKKLIVIDMANLLAEAIRRNHHGGKLVEHMTVFDHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSC9</accession>
    <name>A0A0D2BSC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_01920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241556.1">
        <property type="nucleotide sequence ID" value="XM_016376280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSC9"/>
    <dbReference type="STRING" id="91928.A0A0D2BSC9"/>
    <dbReference type="GeneID" id="27329003"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01920"/>
    <dbReference type="HOGENOM" id="CLU_074237_1_0_1"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000005">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000004">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="75"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW21340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="153" mass="16439" checksum="47AC946D777F91C8" modified="2015-04-29" version="1">MARKAPAKDQIVKLIVGAGQASPSPPVGPALGSKGVKSMDFCKEFNARTAHIHPGVPIPARVTVRPDRTFHFDVRTPNTSWLLLQAAGVKEIKGKIKGANQPGRQSVGTVSLKHIYEIAKIKQSELRLSGLSLQSLCKSVIWQCKSIGVNVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BX28</accession>
    <name>A0A0D2BX28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236075.1">
        <property type="nucleotide sequence ID" value="XM_016380248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BX28"/>
    <dbReference type="GeneID" id="27332992"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05909"/>
    <dbReference type="HOGENOM" id="CLU_020925_1_1_1"/>
    <dbReference type="OrthoDB" id="4161589at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58462" checksum="6D6CA9E874265A53" modified="2015-04-29" version="1">MQHDLNASSTSSPAGNGNGNVFLSSPPQVGRKRKAPSAGSRGVASLTPEQLAKKRANDREAQRAIRERTKQQIETLERRIQELTSQQPYQELQAVIRQKDAIQAENDEIRRRLASVMSIIQPIVGAQGLTGSDCPSTKRPDVVDKFNADLATAAQHNVQAALGQQPEAFHPSNMPASDPYLTSQQGTRQFTTSPNVSHGQMDNSAYPSPFTQEEQGSENNRLWPASSRDALANQRDNLQRGLELNDSGERLSFNFLLDSLGQRTLNPSAQQTTSPTHLTAAYPGPVSMVPDGQVQTPWTTLPKNVAPTCPLDGLLLNFLHARQRDNTNSDTVLNPSHPSMTSLLNPSGDHRADPVSRLMADIISKFPNISELPERVGTLFLMFVLMRWEINPTQENYEQMPEWMRPIPAQLFTPHPAWIDHLPWPRMRERVLMNYQDYPFENWFIPFTSDLNVNWPYDDTDCLLASTSENGEPCMNPVFERHIRRLENWSVGSNFAAAFPGLVDTTRLNLVNRKDGKVTGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXH2</accession>
    <name>A0A0D2BXH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236190.1">
        <property type="nucleotide sequence ID" value="XM_016380363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BXH2"/>
    <dbReference type="STRING" id="91928.A0A0D2BXH2"/>
    <dbReference type="GeneID" id="27333107"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06024"/>
    <dbReference type="HOGENOM" id="CLU_061825_0_0_1"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF7">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29067" checksum="B3401F45A29DDA15" modified="2015-04-29" version="1">MSESIDSLESLHKKKFRLSRWKDHLSADIDESWADLILIVACFISGLVDSAVFNVWSCFVSMQTGNTVYVGLGMSGQPYTQPYRWVKSGTAIISFCAGTYFFSRTARLLGSLRRSTMVVSFVFQATLCFIAALLVVSGIVPPDAGSQIPRSFVVLLPLSLLSFQSAGQIVVSRLLAYNELPTVVLTSTYCDLMFDPHLFTAPLRQNPKRNRRFVSAVALLLGAVVSGFLTEGGNVANPLWIAAAIKVGMAVVWLFWPAKGTIRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZM2</accession>
    <name>A0A0D2BZM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_03989</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237015.1">
        <property type="nucleotide sequence ID" value="XM_016378338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZM2"/>
    <dbReference type="STRING" id="91928.A0A0D2BZM2"/>
    <dbReference type="GeneID" id="27331072"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03989"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_3_1"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:heat shock protein binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000053">
        <property type="entry name" value="Putative Mitochondrial DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008035">
        <property type="entry name" value="PRK10767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="79"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="13">
        <location>
            <begin position="231"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="10">
        <location>
            <begin position="231"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="476"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="509"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW16799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="543" mass="57222" checksum="6B5A70B07AE17EB2" modified="2015-04-29" version="1">MSAAGAAWANSAPRLIRSSIPCPQPSASLTRKAQTRAFYNSAVPKRPSSRLPPCSRSPRCSSPHVRLFSATSAFQATKDPYATLGVGKSATASEIKKAYYAMAKKYHPDTNKDPGAKEKFTDAQSAYELLNDPQKKAAYDQFGAAAFDQGAGFDPGAAGGGNPFGGAAGGNPFGGFGGGFGAEFNFEDLFGAFTGGSRRGRRGRSPFQEEILQGDNIEVQTNISFMDAAKGVTKNITITPLVECGTCKGSGMKKGAQKQQCKSCNGTGTRVHVMQQGFHMSSTCSTCGGSGVTIPRGSECDTCAGNGVIRQRKTVQVDIPGGVEDGMRLRVSGEGDAAPTGAAVGANVRSVRGDLYVFIRVAPDARFSRNGADVLYTAAIPLTTALLGGEVTVPTLDGEVKVKIATGTGTGDKITLPGKGMKRLGGRRDASGDLRVEFKVNMPKYLSANQRTLLEMLADEMGDKTAKRIMNIDSFKKETSSDTNSKPSNKAADHKNEGFLKSAWHRLTHQHDNLEADEKGSQGKADKADSKDDDEPKKASGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0C3</accession>
    <name>A0A0D2C0C3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_04225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237250.1">
        <property type="nucleotide sequence ID" value="XM_016378573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0C3"/>
    <dbReference type="GeneID" id="27331308"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04225"/>
    <dbReference type="HOGENOM" id="CLU_572416_0_0_1"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="264"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW17034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="477" mass="53565" checksum="8992EF43CAA07214" modified="2015-04-29" version="1">MSTADCVFDVPSDGIPRGSEYVASLEARIASLESELRSVRAFSSPPDQLIPDDGSRQLGGHGAVSLLSGKAPLLILEQFLRLLDGGRGQLHILRGLITQQRTPSPSPSSLQNSPESTSEITSFNMLQGGTTTSEMQASTLPELPSQKVGHLLLETVYLYIQARYCIVDWVQLREWHQRRETICYSTKEDDLDSQTGAYFIWIIYAIGAGFVPNPEYPPKAYFARALKYLHPILTLQNSTTVQALLCLCQFHFRTTVNLYRLPIPRHLSGIIMRLCVELGYHRKASSDVMDPLAIELQKRFFWCAYCFDRLVSTMARRPFGIHDLDIDTPVNVNIESTDSEQLEYLQSRQRAGEDGCQIGGLTSMSSALHHLEFYRLKSRIMTRLFGPHALPPTYEDVQELLSKLDKWMATAPRNCPNSLPQQSEIRKQGFYLQAVLLTMRPVLIQQSVDEHLLLLCAGKAADACEVTLQATSIRCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3J1</accession>
    <name>A0A0D2C3J1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02492</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238420.1">
        <property type="nucleotide sequence ID" value="XM_016376850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3J1"/>
    <dbReference type="STRING" id="91928.A0A0D2C3J1"/>
    <dbReference type="GeneID" id="27329575"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02492"/>
    <dbReference type="HOGENOM" id="CLU_030739_1_0_1"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1440.10:FF:000006">
        <property type="entry name" value="Structure-specific endonuclease subunit SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="9">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="407" mass="45650" checksum="856A61571FE67638" modified="2015-04-29" version="1">MELKPIPAFYCCYLLRSTVRHASVYVGSSPDPARRLAQHNGRVQGGAVRTSRDSLRPWEVTCVVAGFPSNIAALQFEWAWQNSHLTRHIPPHERISFAATRTKTSRTGKVTRRPGRPRTSLMDKLSNLHLLLRASYFSRWPLEVRFFSPDAYQSWQTWCGRVDTHISQNIKVHLDPPQMQPPPEQDEFTSAQPVQRKRKADLIGKGGVDGVDPTYAAFREVFDKSQFLLDEEDNQTCSVCKNGIDVQKALFVVCPTENCQSISHVTCLADASLGQQQSASLVPQSGHCSSCGQQHPWSELMQQVTLRTRGMKEVKKIMARKGRNVAISASEVLEEQSEEESEAEAEGLTAEEVIDEEFFDEQEDDDNISIASTDSQMIITATLKADDKIAADKARLEIVIEDSEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C9I0</accession>
    <name>A0A0D2C9I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240455.1">
        <property type="nucleotide sequence ID" value="XM_016375179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C9I0"/>
    <dbReference type="GeneID" id="27327897"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00814"/>
    <dbReference type="HOGENOM" id="CLU_064119_0_0_1"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="1">
        <location>
            <begin position="70"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="344" mass="38910" checksum="7BB6073829924651" modified="2015-04-29" version="1">MAIVPIISSPETEASPAAPSTVEITERMQNVSIAPATPPRSTGATAARFSVSIDATARPTFSGPSVYTERKLMRRDSIERREAFLKGKEGSRQRRRWENARLLSNPWAEPPLPSDFEVHPTYPRRTVPYYLAPLWDAAEFQRAVEAKLKGRKNSTRSRGKRNTGISPMEEAAISIPKEVRARLKRAKAAKGLLQDLEESVRAFVQKWNEREARLREEGLHDVPLASDSEEDEEIVFVGRNGAMHDSPGRRQRQKEEGWDETLSSEKMVFEGLDNDKGAAFARWLVHCVGSYYGLKTWSVTRDVEGEEKRREAYVGVDQRARGFMGRGVEFGRDIELPRPLWGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y6F5</accession>
    <name>A0A0D1Y6F5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_11420</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230672.1">
        <property type="nucleotide sequence ID" value="XM_016385728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y6F5"/>
    <dbReference type="STRING" id="91928.A0A0D1Y6F5"/>
    <dbReference type="GeneID" id="27338503"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11420"/>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_1"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="13">
        <location>
            <begin position="39"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW10456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="433" mass="47352" checksum="A45981E100C45992" modified="2015-04-29" version="1">MSRKSPFDLSKCARPNILKLQPYRCARDDYKDDGHNILLDANENAYGPGLALDSNGTYPAASANTNLSVDFLGLNRYPDPHQHELKQRFCALRNTHTHTRKTLTPANLFCGVGSDEAIDAIIRCFCTPGTDKIVTCPPTYGMYAVSADVNDIAIVHVPLNPDDEFSLQLDAILAKLSQDSSIKMVYICSPGNPTASLIRKADIQRVLEHPTWNGIVVVDEAYIDFAPDGASLAEWVLEWPNLVVMQTLSKAFGLAGIRLGVAFASPEVAGLLNNLKAPYNISSPTSAIATAALSPQNLEIMRTNRSKIIVQRDRLLQELPRIPGVGRFRGGTDSNFLLVEILNAPADQGGKPDNPTALHVYETMAGQRGVVVRFRGKEYGCTGCLRITVGTEKEVDRFLHELRSVLQQALTSNAQADRPDEARREVEANGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y724</accession>
    <name>A0A0D1Y724_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">monoamine oxidase</fullName>
            <ecNumber evidence="2">1.4.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_11660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.4" evidence="2"/>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230912.1">
        <property type="nucleotide sequence ID" value="XM_016385968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y724"/>
    <dbReference type="STRING" id="91928.A0A0D1Y724"/>
    <dbReference type="GeneID" id="27338743"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11660"/>
    <dbReference type="HOGENOM" id="CLU_088988_0_0_1"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW10696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="210" mass="22457" checksum="56EE46EB832E568A" modified="2015-04-29" version="1">MPSAAPNPEMTDVVIVGAGLSGLEAGRHLQRANISCQILEATGQVDGKTRTVKSRETGPGFNDVGAAWINDTSQSEMYKLFQRYGLGAEIQRSTGNTLHEERDGSFVSLPYGELPISQEEAASLGALLSNLDKMIAESCLERPEKSPGAQQLDQITFKDFCIQAGPSPINGHFADNISRGLLGVDASEISTLYMINYFKSGTGIANLSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y9L6</accession>
    <name>A0A0D1Y9L6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_10983</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231897.1">
        <property type="nucleotide sequence ID" value="XM_016385295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y9L6"/>
    <dbReference type="STRING" id="91928.A0A0D1Y9L6"/>
    <dbReference type="GeneID" id="27338066"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10983"/>
    <dbReference type="HOGENOM" id="CLU_031900_7_0_1"/>
    <dbReference type="OrthoDB" id="2505961at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="17">
        <location>
            <begin position="377"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="171"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW11681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="445" mass="48767" checksum="4CF5E33CE2A2095E" modified="2015-04-29" version="1">MAGNEDCASVLEQFIHDASNLPAEINHMMEEIQAKDKDLQKFLSAINQKDANIQKHLKVNGVLAPHPKENEYADLVKKNYESCAQLQDQKVHLADRACNILERQLRKLDTKIKELQNDGQLVDGPPLPSVFNRKAEAQKSLIDVPPSLPLQNASISALNANAHRINSHITTTMQQAQSRQLPQLTTTNTPAQRSSAPATPAAGVQQQRQREREHSAGADTKRRKLTAAANLPAQPSGLRQSSLGPGTPKASTPTATGTSRSGSLPRSAGPPQTAGPPKKSGLSKKIMPHQQVNKLKQKGSTKGRLSVGRKKGQSPSVRGGRGGTAASEEDSVLSSADASETDASTTRGRRGNKKSLREEVETHEDEDMDDDEGEDDKRYCFCNQRSYGEMVACENDDCPFQWFHTGCLNMKKVPDEDEDWYCPTCREKPEIIEKVKARKKAGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YB35</accession>
    <name>A0A0D1YB35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_09395</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232337.1">
        <property type="nucleotide sequence ID" value="XM_016383714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YB35"/>
    <dbReference type="GeneID" id="27336478"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09395"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000489">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="81"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW12121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="579" mass="61466" checksum="9989388DE3B63563" modified="2015-04-29" version="1">MAGLPTSADASATTSLTDISKPPQPIVEGDNEKKQEQEVSLSRQISASDNSVTIEKDETLGRELSRIDTSDYPSAFPLAMIVVALACSIFLVALDMTIVATAIPRITDQFHSLDQVGWYGSAFFLTIGSFQATWGKLYKYFPLKISYLASIFIFEIGSLICAVANDSTTLIVGRAIAGMGGAGIASGSYTIIAFSAPPKQRPAFTGVMGATFGVASVIGPLLGGVFTDNLTWRWCFYINLPIGGAAGFIILLFFRTPKAARPQSATLKEKLLQMDFPGTFTIMAAIVCYLLAMQWGGTTKSWSDGSVVATLVLFGVLVLAFLAVEYFQGDRALLQGRLLKDRTIGAMCAFIFFTAGTFFILLYYLPIYFQATRNVSAAKSGIDNLPLVLGASIFTVMSGGLLTVWGEYIPLMAVGSILASVGSGLLYTLEIDSGSGKWIGYQALVGIGLGLIFQIPVIVGQAVVTPSDLSSVSAIILFFQTVGGAIFISAGQSGFTNKMLEEIPKRAPGVDSGLVVATGATELRKVFDAAQLPGILSAYMEGLRVPFAIAIACACVTFLLSFAPRWESIKGKVKLDAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YC11</accession>
    <name>A0A0D1YC11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232677.1">
        <property type="nucleotide sequence ID" value="XM_016384054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YC11"/>
    <dbReference type="STRING" id="91928.A0A0D1YC11"/>
    <dbReference type="GeneID" id="27336821"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09738"/>
    <dbReference type="HOGENOM" id="CLU_1686591_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="156" mass="17698" checksum="138C87D416BD49C6" modified="2015-04-29" version="1">MGFGSPKYTPQPLHHIFSAVLVFLHGIRHARSVIADLYAVEEIEDIMETFSQASAVTVERRLAATRCLEEYKRLLEPVKQDYLTYTTSRQSLGDNIHGNANSTLGDLNAPEDSGRYMTAFFESVVHMPNEHFHIFDETMPLDWDSGFNLETPAAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YE41</accession>
    <name>A0A0D1YE41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233577.1">
        <property type="nucleotide sequence ID" value="XM_016382874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YE41"/>
    <dbReference type="GeneID" id="27335632"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08549"/>
    <dbReference type="HOGENOM" id="CLU_1161144_0_0_1"/>
    <dbReference type="OrthoDB" id="10503580at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="218" mass="24470" checksum="7D3CA5267631505F" modified="2015-04-29" version="1">MYQGANNYGLPQGSYDPRSPQITVNTGPSYAGGYGPGYGPTYGPGYGPGYGPRYIPGFGRRVGLGCNMCGFRRCRCNNSGGPVILNRGHQTLLSTVVGGAMSMMSDRSERDYEERQVRAQRRMDEDMHYDTRNRGLEQWQLQDQTHSRDAMRDDSRGRQYGIRNRDVQSGRDYSGHESDEENCTGRRIEKRLQGSAKEEGKEVMEEQLPSYQSAAGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YEC0</accession>
    <name>A0A0D1YEC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233647.1">
        <property type="nucleotide sequence ID" value="XM_016382944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YEC0"/>
    <dbReference type="STRING" id="91928.A0A0D1YEC0"/>
    <dbReference type="GeneID" id="27335702"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08619"/>
    <dbReference type="HOGENOM" id="CLU_018496_0_0_1"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="714" mass="76919" checksum="D853B6286D6E440B" modified="2015-04-29" version="1">MAIENIPTSQTLKQAFELNIYTPDGVPVPFGSLFEPHGATADDHDKTASTSSLSSASLSPSTSNHILVVFIRHFFCGNCQEYIRRLSSPASPFHPTRRRAYLNFSKPNTHPPPSVIIIGPGSPSLLSSYAALTKCAYPIYADPSTQLYDMLGMHKTLSMGGKHPEYIQHNLLSGAVKSAWQIVKRVGNGDALDGGDWHVNGGEFLFVQKDTLGQSVSRKKSHPTSRSRSKSNSPPPQPGSRTRSSSRDLTPSGSASSSGAKPGWEVHWCHRMANSRDHTEIQDLYHNTCSSSAFSLPRPGSRTASPTPLRSILVNGGGGHASPFGLLTQSRRPRSQSGSRARSLSRSYSSECLGACPGPDIPKTREEALLSQALYASASTRPGSKASLRPKSRSLSGISSSDKHQWSKSVTSLTRADSGLAEGVGEDVEPRKSFSQSIASRVGILARSKSFSAKANPRTEGVDEHAANQTGEGESMSASVDTSTITGANGRKRSLSSLVRSVSKKYKTRPGVVTQVRPQTATPTSSTQSLTQTSAQSRPDSAVSLSARHAHDEDETDREEEEEEGGGVSSQPTTAHAPARRTSFSLSRRSNRPSQSPSKMSRGASTIEMGEDGIMLVDGVEFVNVISLKARVDGSRRQNQHEPRHHHHHHHQMQPQNHTVGHTHAELVPPQPHTQTHAYEHNQTQLHVHDRMAGSVRPVGSTMALGTAVLSVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YFE2</accession>
    <name>A0A0D1YFE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234022.1">
        <property type="nucleotide sequence ID" value="XM_016383319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YFE2"/>
    <dbReference type="STRING" id="91928.A0A0D1YFE2"/>
    <dbReference type="GeneID" id="27336081"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08998"/>
    <dbReference type="HOGENOM" id="CLU_362476_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="943" mass="106132" checksum="FE4233A2F75D7C73" modified="2015-04-29" version="1">MYDTGVNPGPICAVRHISGRQVEKAHELASRGQQELYDISDRETTVFRSCVSCDEHFAAVEVDILPTWPTPLYAVYELNVRYQPCCHFAFQDARIDHEFQSEIQLIYDTYILPTRRKIDDGWYEEPSLLAIRAELTKTSRTKIPPADVTDASSTCTEKKRQCVLKWSNCHEADDLTIERTSADSPIVPPEAGEESSPVTETPRQVALRHQNPPIPAGDRREIVKVTESRAPEQEQAPTKKRAKKTVKQEAETIVKSVERGMDKIRKRHQKAEKRRLNAEKRQRKQSKSSTLNIMDAPLSDDTLPIIRYKSLEDVEKFQNSDQSVRLKQLRALEQRFVAYSQKVTKRDSWNFWYCAASFSYIRYTYGGKLERRAKAVRVINKVFHQLWLRDGPAALMFFIALAGKQNDNPGRKAVRLTGTERKNTMCIASRLSDQDQDELGRHIIEGLAGKLEDPPLQYEIPVPALWVGVLLGITFQEACTALEMKAFGTLELQSDWEVCQDGLYEPSSYWQHYRYLRARSGFIEEMEVSDDAAAPQAKRLCLEENNQDAESAHDHDNRDSANLLIVSPDEEASLARPLPCTSHDEDGASDSANSTRSLDDIIEIDRTASAGHEDTHHQPKRRRLDGVAPVAFDEQIPDTNSGLRLIQPQSGNSMDFNNFTQNDVISETQSAQHPSNTHHEGSPLDTNSNESNKSPDVHMDGVTMEVIEDHRLHDGSRDEHCSGNDVARMPMNFASEQGSLDVHLHQNGNTASSNVPPDQFTSNMTEVSVDKTTLPERSNGFPCRVGEEAPRNQIPPSTEVVESSNIHGREAEAGEQIAGTAWTSSNETTTNGREDSESEPEEVRRKRRRVDDACTDAFADSEDVNPGTSVPDDMFPRVADNFPNDGFASDDFNPHMEMHNSSGLSGLDDFMLDYPLDQLWNFDQNTMSPGYIDALNSMVLPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIY1</accession>
    <name>A0A0D1YIY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235112.1">
        <property type="nucleotide sequence ID" value="XM_016382010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIY1"/>
    <dbReference type="STRING" id="91928.A0A0D1YIY1"/>
    <dbReference type="GeneID" id="27334764"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07681"/>
    <dbReference type="HOGENOM" id="CLU_007383_19_0_1"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="321" mass="35028" checksum="B987DB37C42BD6A4" modified="2015-04-29" version="1">MRILVTGAAGFVGQIVSKELLGDEAHQLILTDVVEPAVPHGSKYPKHARCIKADLLESAATLIPSGLDCAILLHGVMSSAAEADLELGYRVNVDATRSLLFNLAKKCPGVRVIYASSEAVYGSPVPKNNVTEADFPTPEMSYGCQKVICETLINDLTRRGMINGFSLRFPTISVRPGKPSPAISAFLSGIIREPLNGQTCVIPLKDRAWRHWMCSPKTLVHNILVTVQLPCDALEPHRRAVNVPGFAVTVQDMLDALAEVGGKDKLAFVQEEERPELQSVLYSWADDFDNSLGLSLGMKQDTSFVQSVRDYVESMKEAPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJD2</accession>
    <name>A0A0D1YJD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_07833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235262.1">
        <property type="nucleotide sequence ID" value="XM_016382160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJD2"/>
    <dbReference type="STRING" id="91928.A0A0D1YJD2"/>
    <dbReference type="GeneID" id="27334916"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07833"/>
    <dbReference type="HOGENOM" id="CLU_122625_0_0_1"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="116" mass="13165" checksum="B1EBE8F9B4269595" modified="2015-04-29" version="1">MSFQKPEKDFGEGPKIHKIRITLTSRKVNSLEKVCSELLERAKSKHLRVKGPVRLPTKTLKVTTRKTPCGEGSKTWDMYEMRIHKRLIDLNAPTEVVKQIIINIEAGVEVEVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJV8</accession>
    <name>A0A0D1YJV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">L-ascorbate oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_05311</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235482.1">
        <property type="nucleotide sequence ID" value="XM_016379655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJV8"/>
    <dbReference type="STRING" id="91928.A0A0D1YJV8"/>
    <dbReference type="GeneID" id="27332394"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05311"/>
    <dbReference type="HOGENOM" id="CLU_006504_5_0_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13898">
        <property type="entry name" value="CuRO_3_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000036">
        <property type="entry name" value="L-ascorbate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251995" description="L-ascorbate oxidase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="44"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="187"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="476"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW15266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="68297" checksum="463DAB344FA791F2" modified="2015-04-29" version="1">MAFSRFIVLLSLLSFAIFAYAAPSSYSVTSLEKRAKTVKFEVDLTWEDYSPIGGTPKKMILVNGTFPGPALEATVGDEVEFLVHNHLPDPTTVHFHGIVQQGTPWSDGVPGLSQRPIAPGASYLYKWTADASGVYFYHAHYRSQMMDGLYGAIIIKAAANAPKPFTLISNDTSAVAAMAAAEESQEVIFVSDYVKYTSAEFHEQEAAANVDIACADAIILNGKGSQYCLSRGELTAYTSPKVAPLLATVSPSELTNKGCLPPNLVPTQGNFTFKIDALPPDAYFECTPSTGEMATFDVDPAKGWAAFTFINPGGFELLKFTIDGHKMWVYAVDGGYVVPQLVDQVIINNGDRYSVLVQLNQPAAQYAIRVANNGLNQVISGFGVLNYKGSFGPATQDPNALSKMNFAGANLTLLVPFNDAKAAPYPPNPPAAKADITYQFNIKKLGQPFGAYQWTLSGVDGFNATMEDVEPLLDQDPSKLAPSDLVLTTKMGQWVDLIIKTQGPLAQPHPMHKHSNKAYVLGKGVGPFNWTTVAEAAAVLPNTTFNFKNPPLRDGYTTQPAETNSTWMALRYEVVNPGAFLFHCHVQTHMAGGMAIALLDGVDEWPEVPEEYASGNGLGKLQKKGRLQAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKR0</accession>
    <name>A0A0D1YKR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235797.1">
        <property type="nucleotide sequence ID" value="XM_016379970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKR0"/>
    <dbReference type="STRING" id="91928.A0A0D1YKR0"/>
    <dbReference type="GeneID" id="27332712"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05629"/>
    <dbReference type="HOGENOM" id="CLU_136352_0_0_1"/>
    <dbReference type="OrthoDB" id="5331396at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="112" mass="12422" checksum="C62182652EC57FAD" modified="2015-04-29" version="1">MASRLLVPRFSSASRSIRASAIPSRSFQTSSRRLQEIAATPVKKPVGAFRGGLFGFLLGSTLAGASVYYYILEEYKVSNELLTEDIYALQAAVQRIHSYVTELDNKMAQMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKW3</accession>
    <name>A0A0D1YKW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235877.1">
        <property type="nucleotide sequence ID" value="XM_016380050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKW3"/>
    <dbReference type="STRING" id="91928.A0A0D1YKW3"/>
    <dbReference type="GeneID" id="27332793"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05710"/>
    <dbReference type="HOGENOM" id="CLU_054362_1_0_1"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005725">
        <property type="entry name" value="PRK07539.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="226"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW15661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30760" checksum="C2238E53591E3AD6" modified="2015-04-29" version="1">MASKAIPHLVRQATRAASRASQAHPQRQPLHIRPFSSTPSSRSEALFVHRNTPENNPSIPFKFNNTNLRLIDEILKRYPPQYKKAAVMPILDLGQRQHGWTSLSVMNEVARILEMPPMRVYEVATFYTMYNREPVGKYFVQVCTTTPCMLGGCGSDKIMKACEEFLGVHSGHTTEDKLFTLLEVECLGACVNAPMVQINDDYYEDLTPETMKTLLQALKDSSTISGYDASKVPRPGPQTYEGKQRETCEPRGGLTSLLGEVPRVQDHMRTDGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNC5</accession>
    <name>A0A0D1YNC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236782.1">
        <property type="nucleotide sequence ID" value="XM_016378105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNC5"/>
    <dbReference type="STRING" id="91928.A0A0D1YNC5"/>
    <dbReference type="GeneID" id="27330837"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03754"/>
    <dbReference type="HOGENOM" id="CLU_020880_3_1_1"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002247122" description="3-phytase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="65"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="406"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="472" mass="52219" checksum="FAB1AAC15303D29C" modified="2015-04-29" version="1">MVAFDILATCLLASSVSAGGHNSYLEKQFPQTFYDSYNVLKYTGAIGPYSDRVGYGIDPDPPESCAVDQVIMLMRHGERYPDAYTAAGILHALEKVYASGITKWEGDLSFLNTWTSFLSQPGYFEQETFSGPYSGLLNAFKRGSEYRSKYGHLWDGQSTIPIFAGGYERVVETARYFGMGFFGYNYSTAAAMNIISENYTEGANSITPTCLADTGLLSCFFTPRMLPPLAVAAERFNFQNPALNLNSSDIKSLMSLAAFELQARSHSPWVDAFTLDEWVAFGYLQDLTYYYCAGPGDPYQVAVGQVFANASLALMQSGPEHLSMSWNFAHDAYITPVLAALGLDTPSSPLPNNSIPFPNTYRVSDMVPMGGHLVLERLSCNATALSTSGTFVRAVVNEAVVPWPKCQTGPGYSCPLEDFSDIVHQIPNFVEKCGVAKAGYPEYLDFWWKYNTTTDLNYQKGPIRYQEKYTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWH6</accession>
    <name>A0A0D1YWH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239867.1">
        <property type="nucleotide sequence ID" value="XM_016374591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWH6"/>
    <dbReference type="STRING" id="91928.A0A0D1YWH6"/>
    <dbReference type="GeneID" id="27327308"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00225"/>
    <dbReference type="HOGENOM" id="CLU_005679_4_0_1"/>
    <dbReference type="OrthoDB" id="5405781at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="30"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="372" mass="40389" checksum="4DE66A8B03CF23A8" modified="2015-04-29" version="1">MGFVNALAPLRLARSGQVDKTLSKLASSSFSRIFRLVLPATVATIISWVICNMGLYTTAEMSDAFWLHSTAPSPSPNWLQAVPDLLRGISATWAFGQQNPYDQPQWALIYLLQGSFMIISALFLTAHMTPAWRTATLSALIFWSLNWSRLIGDPWTGLCCFAGIMLAEMSLAGGAEALSDISPILAPLSILVGLFVMSYPGGYPDAASWSRMMHAFGLRFLPTEAVDRMYGSLGGIALVFGIIISPHAHCVLSSKPLEWLGKVSFAIYLLHGMLLRTVFAWLLHLGQSLTPFVENEDGIDVDVNRYPVPGFFQCAFATVVSAACIAAASQVWTLKFDPLFGKITATLEGVTAGKSFVGVKSSEDPVLPTRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWJ3</accession>
    <name>A0A0D1YWJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydantoinase/oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_00245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239887.1">
        <property type="nucleotide sequence ID" value="XM_016374611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWJ3"/>
    <dbReference type="GeneID" id="27327328"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00245"/>
    <dbReference type="HOGENOM" id="CLU_007154_0_0_1"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1610.10:FF:000001">
        <property type="entry name" value="Hydantoinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="203"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="3">
        <location>
            <begin position="607"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="4">
        <location>
            <begin position="769"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="996" mass="105443" checksum="601C00BFD6CF2BF5" modified="2015-04-29" version="1">MYRIGIDVGGTNSDAAIIDINEIDTPSRGVLATCKTPTTAHVTLGIKEAVEKVLLESKVDRSKVLNVAIGTTHFVNAVVENDARRLSKVAVIRLCGPYTKKIPPFCDFPYALRNIIEGPHYYLDGGLEIDGREISTLDPAQIKRTADEIVAQGIQYVAVVGVFSALDHQGIHEEKCKALLQEYYPSLSVVCSHSIGGPGLLPRENATILNASILAFARKTIKGFRLAMAKLDLACPLYLTQNDGTLTDAAVAAELPIKTFASGPTNSLMGAAFLQGLDHGDKKTADKQFVVVDIGGTTTDICALLPNGFPRQAPNFVEVGGVRTAFSMPEVYSIGLGGGSRVRQSADGGKVTVGPDSVALRLTTDALVFGGDVMTSTDVVVASGAASIGQADKVKHISPELISAVKADMKRQLERAIDNMKVSSAPVSVLLVGGGSIILTDDLALDGVEECLRPPHHDSANAVGAAIAKVAGEIDVIEVLAGRDEDAAVEAAKQAAIKAAIANGADESTVQIVEIKKIPLQYVTNKATRFVMKAVGNLRVRDGPGCAHSNGVSSADIGEDFEAIEEVKKAEVTKVEKGSLAKPAMEVDLTQYRPRVENGIWYISPVDVEMIASGAGVLGTGGGGSAYLMALYTQNLLRDGAEGKIRVMRPEDLKDSDICVFGAGYGAPSVSDERISSGTDVFTAIDAVNTIMGIKSFDAIVTDEIGGGNGLVTMPTSAKYDRPIVDCDLMGRAYPSLEHGTPYVYGFPVLPVATADCKGNCSVTLTAESNRKVESLIRTTCVELGNSTGTAGRPLEGKVIKKYTVTNTISQAWYLGRAVHLARQTKLDFIEAIASITPVKSLYTGKIVDVTRDVSRGYTVGKVVVAPLAADEEEGTSPSSTASEKRHLVIPFQNEYLSAAYVDSEKGEGKEEVICTVPDLISILGQDGEALGSPELRYGLKVRVIGLPAHPLWTSTPEGLKVGGPEYFGLGTEFKAIGEYQKPRSVIDEFGTVGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWU4</accession>
    <name>A0A0D1YWU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239997.1">
        <property type="nucleotide sequence ID" value="XM_016374721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWU4"/>
    <dbReference type="STRING" id="91928.A0A0D1YWU4"/>
    <dbReference type="GeneID" id="27327439"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00356"/>
    <dbReference type="HOGENOM" id="CLU_020336_7_0_1"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36530" checksum="E2C7534A6B433173" modified="2015-04-29" version="1">MDKLRKKALTVSRGYSYTYSTHFHGSSSSSSRGTILLLHGWPDTASIWSTFIADHLIPHDYNVIAPDCLGGSSRASSVSATTGARVSPAACTTSTLLVSAGPYFAPTPAPFDLDALIAVSQERLGYGAMWYWKLFTADDGAEVLNSHVEGIWTILRALPETWLDTLCGGENAVREFLLRGTAKKEKKKKKKKEKEKKKKKKKKKKEKKKKKKKIIKKTLELMPYATEERKQEFIDLVSKNGFEGPLRWYRGLTFGVQDEANKEAAENDTVVVGGDRDVRCRIEDLQAQIAAGLLPRADVRVLKGSGHRCTLSDPTGFGDAVLDWLDGLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWV5</accession>
    <name>A0A0D1YWV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_00371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240012.1">
        <property type="nucleotide sequence ID" value="XM_016374736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWV5"/>
    <dbReference type="STRING" id="91928.A0A0D1YWV5"/>
    <dbReference type="GeneID" id="27327454"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00371"/>
    <dbReference type="HOGENOM" id="CLU_038839_0_0_1"/>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF32">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G04120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="185"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW19796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="349" mass="38759" checksum="9F38D2025DED81F6" modified="2015-04-29" version="1">MPKPTHITCLCGDIFEPASILPFEELPVEKHLCHCNICRYSTGALCASYFELKGEPSAKSLDRATAYHTPKYVRYFCKNCGCNVFAVGKTDDNNRWLACSGTLETDRKAADDVVVNVSKITAHIYVGDAADGGIAPFLSTIRGQEVPCYEVEDVGTAMDKAQLSLLRKGPPPPPAEKVLERGDTLNAACHCGAVRFQIKPPAYDEKSEGWYVPPDRTKYYARLCCCRSCRLSIGFTMQPWAYVPPGQILTDDGQPVLFGPQHKETTQLGALRYYQSSDAVLRGFCSTCGATMLYQPFERPYIIDVSVGILRSKHGNTMAREWLDWDRTVVSKLAEAADDDLARAWMQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZD6</accession>
    <name>A0A0D1YZD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DASH complex subunit Hsk3 like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240882.1">
        <property type="nucleotide sequence ID" value="XM_016375606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZD6"/>
    <dbReference type="STRING" id="91928.A0A0D1YZD6"/>
    <dbReference type="GeneID" id="27328326"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01243"/>
    <dbReference type="HOGENOM" id="CLU_149439_3_0_1"/>
    <dbReference type="OrthoDB" id="3358869at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10050" checksum="5A464BE674E3185E" modified="2015-04-29" version="1">MDRNNYPGSKHQQSSATSMNATSTNKNRQYAHLHAQLAQLNAHLADTENLVRMTAVQAQDMRFLGGYVGALFMGSAKVLGEESVQGGRGREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZX3</accession>
    <name>A0A0D1YZX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ran GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241087.1">
        <property type="nucleotide sequence ID" value="XM_016375811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZX3"/>
    <dbReference type="STRING" id="91928.A0A0D1YZX3"/>
    <dbReference type="GeneID" id="27328532"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01449"/>
    <dbReference type="HOGENOM" id="CLU_028747_3_0_1"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="44715" checksum="50529518B701E35F" modified="2015-04-29" version="1">MAGETFSLAGQGLKLDTKEDLEKHIAPLQASSNITHIDLSGNTLGVSACEALAPILSSKSTLQSADLHDIFTSRLLEEIPPALSSLLTALLECPNLHTIDLSDNAFGLNTKDPLVDFLSKHVPLKHLILNNNGMGPIAGTSIAEALVALAERKEAARKEGRDVPHLESIVCGRNRLENGSMAAWAKAYEAHKDGIKSVKMTQNGIRPEGISHLITAGLRHCGNLEVLDMQDNTFTLKGALALAKTLDGWSGLKELGVGDSLLGGRGSVRVFESLAAGGNAGVEILRLQYNDITPAGVKALVQAARDGLPKLRRVELNGNKFEEEDPSVEALSELLSERKDEHGKDDDPEEHWGLDELDELEGEDSDEEEEEEEEEDEARAKLVEVDDQAEEEAPVAQRKDAEVDELASKLEKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z048</accession>
    <name>A0A0D1Z048_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241147.1">
        <property type="nucleotide sequence ID" value="XM_016375871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z048"/>
    <dbReference type="STRING" id="91928.A0A0D1Z048"/>
    <dbReference type="GeneID" id="27328593"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01510"/>
    <dbReference type="HOGENOM" id="CLU_064111_0_0_1"/>
    <dbReference type="OrthoDB" id="5402929at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="233" mass="24952" checksum="FC872BD64B5FC911" modified="2015-04-29" version="1">MTSADLHTALLRPAVIQILRAAGFGYAKPAVIDTLTDLAARYLLLLSTSTAQNAFNTHNTFVATVQDVRLALSQAGALTPQMSTVEEGLKEDVEVDGVRIPFEDLRGVQGFVNWAQGPVNKEIRRIAGFGDDANVEEIAAGLDDKEDYLTALKKKHSKTGEESRYQGTVLGKDNELQSVAIVGGPAASLSEWAQKSFSRREAFDPKEAASPATSGISSAPLTPIDDDLSMSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAM6</accession>
    <name>A0A0D1ZAM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230268.1">
        <property type="nucleotide sequence ID" value="XM_016386136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAM6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAM6"/>
    <dbReference type="GeneID" id="27338911"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11828"/>
    <dbReference type="HOGENOM" id="CLU_013260_4_0_1"/>
    <dbReference type="OrthoDB" id="3014581at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="76694" checksum="3891188E25BB9BFB" modified="2015-04-29" version="1">MSHEVTTFLWELLVCEEFLRSYSAPSVLTPTIYSEVRGQLDLGPPNRHIADIYGRLSRLEKSTHAVTAYTINDTSPGPTEPSNERIANASNNAKDWEELESTVASSTPRQATNLDKSKIASQYNVGIPSPDPAASTVKLGCGSNTHLNSGCNASDLVRQLPTVYTARLLFEHYVQVVDCMHRELHVPSASILLEESYSLLAKSLEVSREVLTFLFCIFASSSFHICHAHCHLAPKGLTDSSQWSAVWKMTASDLIYDRRVMVSTSLLSLQSVSIMLLLEWNSEGQSAEFYALKSIAYQKAISMGIHRLDAGAGGKDGNVIESELKRRLWWHLAASDWITASIPGNQEGMYSVNPAHARVTYPANLDDRVLSNSHPPVNLPEDQPTSTSFLIQRAKFAELCRQLADSIQNAGITEESQPCNLTYEFSHRLRRFEEDLPWFFRMDEENKDKANALALNRPYLVPQKHFLLFGIYSRIVRLHRPFLSMKLREPEFSESRTVCLQYAEKILKLRNSIDLSGICHCVNSYSIRQHTFGALLLLSMDSMLETDMFRAQPRKAELIEISKTLRDKEMSSNRSSSGIVFGIDKLIDLLRKSTLDTPVLDSSSSSTERTAQVTLQNPSRLPLSDINAPVTARSLPDYFSEPSHTTSPMPMPMPTPIFSEVTLDDFLNQIDGMEGFDWDGIFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAX7</accession>
    <name>A0A0D1ZAX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11128</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230383.1">
        <property type="nucleotide sequence ID" value="XM_016385439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAX7"/>
    <dbReference type="GeneID" id="27338211"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11128"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="66"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="555" mass="61706" checksum="239D7AEC73189AB5" modified="2015-04-29" version="1">MGLGILDDNKLEHVPGTALLADMLDAQHHQYHGRDTSNLKHGTGRNADIVLVPQPSDSPRDPLNWPTWKKDLALLIISVDTAVVGAWGPMISPGFAEMAEEWHMSYNALNGGLGWAIFAIGISCFVTNALSVKFGRRPVMILGNLLLFISSVWGYFAHSYHSLLASRIFGAIGMSPFEVLTTAIIGDMYFVHERGLRLAFWGLCLSIGVGGASVISGYIIQDIGWNWTYGICACFYGAFIILIFFFVPETVYQRDPAYNLDLGTHDHTFETLDAQVIKGGHPEHLEKTKTGSKVHTEVIYTGADEKPYTFWEELKPVRGIESDENLLYIIFRPFGMLLFPQVLYGFITYGLSTSWLVVMISVLAQLFTGPPYNFSVSDVGLISIAALVASLLGFVAGPLNDWTVKKLARMNNGIYEPEFRLALNVLTLVLGVVGFFGFGATLQNEAPWAGPVVLYGIIYFSMSFLNIGVYGYITECHRNKAPEAFASINLRNIYSFGMNYFISSWISNQGPLEVFSIIGGVHIFILLLTIPMWIFGKRCRSFTARNPFFRKIQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZBN7</accession>
    <name>A0A0D1ZBN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="17">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PV08_11380</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.</text>
    </comment>
    <comment type="function">
        <text evidence="17">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of pre-60S ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="17">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="17"/>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230633.1">
        <property type="nucleotide sequence ID" value="XM_016385689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZBN7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZBN7"/>
    <dbReference type="GeneID" id="27338463"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11380"/>
    <dbReference type="HOGENOM" id="CLU_003041_26_4_1"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="46"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="292"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="533"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="593"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KIW10417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="639" mass="71026" checksum="F9D4D3AB3F2D5AF5" modified="2015-04-29" version="1">MAPDRGQKSSKSRAWDSLEPAISPWILDALSSMNFSRMTPVQASTIPLFMAHKDVVVEAVTGSGKTLAFLIPAVEKLLRLEEPIKKHHVGAIIISPTRELASQIYNVLLSLLDFHPASAATRRALDAPDESVPETAQEAASASTLKIVPQLLLGGATTPAQDLSTFLKTSPNVLVSTPGRLLEILSSPYVHCPQSSFEMLVLDEADRLLDLGFKDDLTKILNLLPKQRRTGLFSASVSEAVDQIIRVGLRNPVKIAVKVKGANGVEDKRTPASLRMTYAVTPASHKFPALVTLLRGLDTLPLRTIVYLSTCAAVDYFQALLPAILPSETILVPLHGKHPANVRQKNFIQFTNSVSPAILLTTDVAARGLDIPSVDLVVQIDPPSDPKAFLHRCGRAGRAGRKGLSVVFLLPGREEDYVSFLSVRQTPIEPLTDPNISVTEDECRAVEEKFRKAVLKDRGLHEKAQKAFVSWVRSYSKHQASSIFRVADIDWTDHASAWGLLKMPKMPELKTWDRSSYRPPAVDWDTYAYKDKQREKQRKQALREGPPKGEDVSERKKEKNLNDKKRSSTVAWSEKIERKATKEVKRSKKAARREHDRIAKLTDAEREKEAETARLVRQIRQNHATATAKDIHDTFEGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZGR9</accession>
    <name>A0A0D1ZGR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_09432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232373.1">
        <property type="nucleotide sequence ID" value="XM_016383750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZGR9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZGR9"/>
    <dbReference type="GeneID" id="27336515"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09432"/>
    <dbReference type="HOGENOM" id="CLU_035429_0_1_1"/>
    <dbReference type="OrthoDB" id="5364404at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd23699">
        <property type="entry name" value="At5g63150_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="351"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW12157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="385" mass="43313" checksum="E430A64921929650" modified="2015-04-29" version="1">MFNTSLRRVARNCSNGSAVPSRPTTPSIASFTSHAHQRRHSSSKPPVPPNNGSSAIPAASVKQVGTPRSETKRPGSESRLSKKRSSKDKVDAKEEVQDDWTSKLPSVPSLQHLNPKDIYVSSFFSTHRPLSITGPVPSETSLDAFDKIFQPKPRTKLHPATQDVIYTLSSAVESLDEQIASRRGEHNHNQGAEQKAAIIKALMQRNNENTADPNRTRHLDGQSQTININGGNVKLVLQDLARRFRPFNTPPAPTPLSDTEIEAAEAQAAAEEAGEEMQARFLEVEIQNQDNDPYVQQVVMNVIERDSSDHDGFFTPHSSPMMEIEDASTMREIQEQVRGRRLGHRRRPAMYAISVKRQRRLKMKKHKYRKLMRKTRNARRRLGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIF4</accession>
    <name>A0A0D1ZIF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_09925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232863.1">
        <property type="nucleotide sequence ID" value="XM_016384240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIF4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZIF4"/>
    <dbReference type="GeneID" id="27337008"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09925"/>
    <dbReference type="HOGENOM" id="CLU_012062_18_0_1"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="53"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="195" mass="20938" checksum="1FA9D580FA3BDE4E" modified="2015-04-29" version="1">MSTEMEIDAVAPASDERDNGTSSPTETKKASAGAGSEARTIQNAVAVRSIEGWIVIATNIHEEATEEDITDLFAEYGDIKNLHLNLDRRTGYVKGYVLIEYPTQVEAAAAIKALNGAKLLDQTISVDYAFVRPPPKDNKGGRGGAGGGGKANERRGGGARAGRSRSRSKSRSRSRSVDAERDRRSRGDGDKMDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJV6</accession>
    <name>A0A0D1ZJV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233313.1">
        <property type="nucleotide sequence ID" value="XM_016382610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZJV6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZJV6"/>
    <dbReference type="GeneID" id="27335367"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08284"/>
    <dbReference type="HOGENOM" id="CLU_008198_0_0_1"/>
    <dbReference type="OrthoDB" id="4160321at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clr5" evidence="4">
        <location>
            <begin position="10"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="547"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="606"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="639"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="674"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="790"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="825"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="862"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="961" mass="105168" checksum="80164095B73E99BA" modified="2015-04-29" version="1">MSGTDPSPTNGWHAHRETIRQLYLVENKTRAEVRCILSKPPYNLETTEWEFEKILNDMNLKKNIRKEDWQAIAYHIEKRKQNGLASDVFLGPLRVKRRKVQHETSRYRSTSVSALAAKSPRLSEGVIIRTPSPTSQQSRAILAPVHAASVMNTINTTDSSILAYPFTTGPSAFDTALEDLPFSYNPEAFDDSVMPNIDFDIESFDAVPLSCFRIPDDTSTHTFDYFALEEAEEFIALSQGDWNLELSNGGNVDTVVYSNKIIEVALCILSNNVSALNGAGQLLEWIRKHTSVDLFKRISLLKSHTTRTIAAKLLGIAVERGDWSIFQFLLDAGIETSLLAGAEGGRLLRKALSHSNPRIATFLIGNRADVNPSDADLGPNECLPLCIAVRKGHTEIARKLLDNGAHLNRWCSGPRIGGTPLRISVLYGRLDCARLLLEAGAKAEKICFDGMDVLDWCFLKDETTLYDLLQSSMSDSSPDFSIRDILLSAKKGVKGLENYLERKKGMGLSCLTRLLERAMHEGFRYSSHRSSAVTLLEYGVDPNIKERRTSLLNIALQYGDLELATLLLDNGADIVSTGAVTKAAECDSRLEFLNLFISECEDLDLLGADPLVTAIENDNFAGVKLLIRSGVPLNERNSEGRYPIQEACQGGNIDMVEYLVQKKADIHAQPSSKECFTALHFAVEGGHIDIVKFLLQNGANVDCQSHGSRGRTLLEVCTHRELLEKANFDRDEMFKILIDAGSPIDGPPVRRCRQWNSALTGLILGSANDELIELAFNAGADVNSPGSGKGARSPIQAAAQVGNLRLVKKLLAKGADINAPAAVFHGRTALQAACSQNVPNEELVRFLLQNGAEVNAEAGIDGGVTALQGAAIQGHIKIVLLLHDAGADVNAPPAPKNGRTALEGAAEHGRLDTVQLLLNAISASGKTWRVGYDRAIRLARKNSHYAVSELLESQPVEQVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPE6</accession>
    <name>A0A0D1ZPE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234903.1">
        <property type="nucleotide sequence ID" value="XM_016381801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPE6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZPE6"/>
    <dbReference type="GeneID" id="27334554"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07471"/>
    <dbReference type="HOGENOM" id="CLU_042179_3_0_1"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="61"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="306" mass="33032" checksum="7596D73DE56241B4" modified="2015-04-29" version="1">MSFIASQGPSSMQSQSDKPSETTGEAYEAFCKKHKIQPEITDLEEGGRALSLGSATAGKTVLWFHGGGYNLAATPAHFAFFWQVIQQAQKEGHDLRVVFLEYELAPHGVYPLQLKQAVASLKYLLSTGTRPSLIIIGGDSAGGNLTAGLLGHISHPKSGVPELALSGNLGGVLFLSPWVTFEQNAPAFKENFYKDGLGLEALKTWSDNFMAGAAPDNYNTPLDAPAEWWKGIKVDGANVAVVAGANEILVDDIRAFKDHIKVNNPNLEYLEAADECHDALVMDRAFGLSAPLASEDFCKKWILARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTQ9</accession>
    <name>A0A0D1ZTQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236373.1">
        <property type="nucleotide sequence ID" value="XM_016380546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZTQ9"/>
    <dbReference type="GeneID" id="27333291"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06208"/>
    <dbReference type="HOGENOM" id="CLU_1981641_0_0_1"/>
    <dbReference type="OrthoDB" id="10604997at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="137" mass="15307" checksum="F38365DEF2E69764" modified="2015-04-29" version="1">MGDHHDHHHHMPSIKHTHQPRNAATNLAPLYLLMLVVGGIILVTKPLLVLLVILLVGYGRVYHVEPAKKSRTPWWSPSPSHHHETTPGYVIQLGPQHQGKQHHDNLSLRDLGFGKNLKGLDSHFGGGGEKKKARFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZVU9</accession>
    <name>A0A0D1ZVU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237048.1">
        <property type="nucleotide sequence ID" value="XM_016378371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZVU9"/>
    <dbReference type="GeneID" id="27331105"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04022"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_3_1"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="59967" checksum="1BEBDAD73C64155B" modified="2015-04-29" version="1">MDDSKINTSDVNVAAQDSSLPKFEAHTEGEVRETVLLRDFNLWSTLGIGFSYIATPLSVGTYLAFSLSAGGSPYFFYGYVVCFVFQTLVVLSLAEIAGFLPHTSGRQPKPTFHGSCTDSSPGQIFWTSQLAPPAYARPLSYFTGAFTMMAWTFWTAATFLFTAQLVLAFVQVCGATWDQEDYQVFLLYVACSVYGFFMNTWGFKIMPFMSKVMIGYVNLGALFILIALLARATPKPSARQVFVDIVNETGWSSDGMVFFLALLPGLTALNGFDSAAHMSDEVPHPAKQIPRVMVGLVLLCGFAGLPMVIAVLFSVTNPDNLLTSAQPIFQLFHDSMRSLPLAILSCLIYLGLFFFACGSIVTTLSRVWWSFSRMGSLPWAQWQGHLTPGWLLPVNSIIVVSILEVFIGLLIFGPTTVLYGITGSAAVCFFFSYMIPIVCLLIKGRKSLPKSRYFNLGRLGPVINIISLAWAALVTVFLCFPTYYPVTTTSMNYASAAVAVGLFLFALMWIFHARKHYVVPGALLSSEYHEDHQGATVVSYSEIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWE6</accession>
    <name>A0A0D1ZWE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237203.1">
        <property type="nucleotide sequence ID" value="XM_016378526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWE6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZWE6"/>
    <dbReference type="GeneID" id="27331261"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04178"/>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="OrthoDB" id="10019231at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF55">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="247" mass="27344" checksum="53030565113DDDB9" modified="2015-04-29" version="1">MGDCCKTGFRWKVSTFEGKETKIAGLDTYVVGNNKDVAILIIHDILGWTSPNLRLLADHYAPEIKATVYLVDFYGGEIVDPLTMRDPEKLKRFDVGAFLGRHNKATRGPEIFAAAKALKGELGYKKVGALGFCYGGWAAFQLGAKGNDLVDAISTGHPSMLEESEVDNLAVPVQILAPQNDPIFTPELKAYCNKVIPQLNIEYDYQYFPGLAHGFATRGDPNNLVQKKGLERAKDAVVFWFLQHLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZY98</accession>
    <name>A0A0D1ZY98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237838.1">
        <property type="nucleotide sequence ID" value="XM_016379161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZY98"/>
    <dbReference type="STRING" id="91928.A0A0D1ZY98"/>
    <dbReference type="GeneID" id="27331900"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04817"/>
    <dbReference type="HOGENOM" id="CLU_030571_1_1_1"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF4">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36332" checksum="F1A82BD7BAA3B94E" modified="2015-04-29" version="1">MTLPSTKAHVDLRLLNGGSMKANTKTIHDGVSDDDEDHMFRLYDWCFYIYQPELRRHVLWDVGMSNDGDAYISSIRDVMKVMSCVGPDKPLAQQLRDSCGVEPETIDTVLFSHAHFDHCRPIRHEFPNAHGFFGPGTEDDCKRKLEPWCTDPGVGHKFDPRFFDRARSTETWSELKGPWVPFGPFDRAMDFFGNGSLWLIQAPGHMQGNLCAAARLADGSWVVLGSDCAHTKPLLDGKYDIAEVTRPDGSKWSLHEYVCAAKETIAKIHSLEVDHGCHIALAHDASWMLKQTAEEKDPVLFGLLGDDFTEDVRERVARDEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0B3</accession>
    <name>A0A0D2A0B3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238643.1">
        <property type="nucleotide sequence ID" value="XM_016377073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0B3"/>
    <dbReference type="STRING" id="91928.A0A0D2A0B3"/>
    <dbReference type="GeneID" id="27329798"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02715"/>
    <dbReference type="HOGENOM" id="CLU_035063_0_0_1"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="41"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="396" mass="43665" checksum="C692C27C13AD9AAF" modified="2015-04-29" version="1">MKGILPVPRPICWPPKLVDNELGIATLSLGNWREHKLTSRLEAAARAGFRWIDLFDECWAAYLEENGLDGEKLWDPTPENLRVAHKLGDLVKALGMRISCTQPLRKIEGIKDPVERRATLDLVAKRFPFMRAFDTDLVFMCASIRTDGGVTSDLKTVAQDLAEMGDLAAAFAQADGGKMLKIGYEGLSWATRNTWSASWEAVRAANRPNVGLVVDAFNVLAVEWADPYNSALHGRIYSTLQESIALLCLSLASLVASVPGDRIFFFQVGDAELVDPRSFQGPAEPETPALLPWSRGHRLYPLETAKGAYMPVELVAAAVLATGYKGPLSLEVFNTSLNLPGDNVPTDHARRGISGLRKVQDLVKLVPAFWDASQEVPVEDLVRLYQTNRQQRSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A110</accession>
    <name>A0A0D2A110_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_02951</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238878.1">
        <property type="nucleotide sequence ID" value="XM_016377308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A110"/>
    <dbReference type="STRING" id="91928.A0A0D2A110"/>
    <dbReference type="GeneID" id="27330034"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02951"/>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_1"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="218"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="246"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW18662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="545" mass="60132" checksum="2392FB178A512C6E" modified="2015-04-29" version="1">MAANGETTEDAVNVPAKTFDTVLVLDFGSQYSHLITRRLRELNIYSEMLPCTQKISELHFKPKGIILSGGPYSVYEDGAPHVDPAAFDLGVPILGICYGLQELAWHHGKNVLAGEKREYGHAYLKIERHSGKEEHIDRLFEGIEDDIEVWMSHGDKLSKLPDGFHPIATTANSPFAGIASTDKPYFGIQFHPEVTHTPRGTQILSNFAVNICKARQDWTMEKFVDKEIERIRALVGPKGQVIGAVSGGVDSTVAAKLMQEAIGDRFHAVLVDNGVLRLDEAKIVKETLTEHLGINLTVVDASSLFLGKLKGVSDPEKKRKIIGNTFIEIFQDKAKAIAEAAANSPKAGEIEWLLQGTLYPDVIESISFKGPSATIKTHHNVGGLLEGMHLKLIEPLRELFKDEVRALGTNLGIPEHLVWRHPFPGPGLAIRILGEVNEEQLKIARHADKIFIDEIVAAGLYRKISQAFAALLPVKAVGVMGDKRVHAQVIALRAVETTDFMTADWFPFDGDFLKRVSRRIVNEVDGVCRVVYDVTSKPPGTIEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A1B3</accession>
    <name>A0A0D2A1B3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S1/P1 Nuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238978.1">
        <property type="nucleotide sequence ID" value="XM_016377408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A1B3"/>
    <dbReference type="STRING" id="91928.A0A0D2A1B3"/>
    <dbReference type="GeneID" id="27330134"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03051"/>
    <dbReference type="HOGENOM" id="CLU_044365_0_0_1"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238014" description="S1/P1 Nuclease" evidence="8">
        <location>
            <begin position="19"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30821" checksum="440CE22DC3302CE8" modified="2015-04-29" version="1">MKSAVILLPSLFTAAAKAWGGLGHETIAWIAQSYVSTTTAAAVKDLLDSKQSDYMANVSTWADSYRYTSAGSWSAPLHFIDANDNPPSSCSVDYGRDCGSSGCSISAIVNYTSILRDVDSKQAEKYYAVKFLIHFIGDLHQPLHDEALERGGNGINVTFQGKHTNLHHIWDTEIVELLANGSSAEQLARTLTASIKTGEYGWDVESWLVGTTLNDTVSTALTWASEANAYVCEDVLSAGIDAVEEGDLSGSYYQAHFDVARTQIARAGYRLGAWLNLIFTGQTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A1L5</accession>
    <name>A0A0D2A1L5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U2A'/phosphoprotein 32 family A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239068.1">
        <property type="nucleotide sequence ID" value="XM_016377498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A1L5"/>
    <dbReference type="STRING" id="91928.A0A0D2A1L5"/>
    <dbReference type="GeneID" id="27330224"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03141"/>
    <dbReference type="HOGENOM" id="CLU_044236_0_0_1"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000446">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit SDS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF23">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="7">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="400" mass="45292" checksum="DE5994286B31AA30" modified="2015-04-29" version="1">MVEQPTQDQAQPESQGDHQAHPHIELPPSDSSHEHSSAPLVNSNGWDGKLRMPSRHAVLSNPEALSDPEYSDPDAPPTDQIDADEDLLDDYPQDSEDVDLVHCRISSIPALKLERFSQLKRLCLRQNAITTISLPENFGETLEELDLYDNLISHVKGLDALKNLTSLDLSFNKIKHIKNLNHLTKLTQAFFVQNRISKIENLDGLENLTMIELGANRIREIENLEPLKNLQELWLGKNKITEIKNLSPLTNLRLLDIKSNRLTSISGLEELSNLEELYVSHNGITEITPSALANNKKLRVLDISSNQISHLENIGHLKELEELWASSNKLADFREVERELADKANLETVYLEMNPLQLSGPAVYRNKVRLALPQVKQIDASKYKTLCTNFNMYERALLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3I3</accession>
    <name>A0A0D2A3I3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239663.1">
        <property type="nucleotide sequence ID" value="XM_016374387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3I3"/>
    <dbReference type="GeneID" id="27327102"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00019"/>
    <dbReference type="HOGENOM" id="CLU_015676_3_0_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="65798" checksum="AD5B6F5EE8FC0CB7" modified="2015-04-29" version="1">MIAHYRTPAATFDDVPGELPGSTLAGTKAQNAEVSDALSLLNGLQFDDLADNVIWRDLLALTGTYRTIYSPSKVFTTFQKLSQLRSRSAFSQTNRPPRISTALGKSWTEVDFDFEVQHGTLSALCSGTVSLILGLDSKWRIWMIRTWLESYRGHGDPDILEPKVKGSLGNGKLDTEYDAVIVGGGQAGLSLAGRMQALNLNYTLLEQNAELGDIWNQRYESLTWHTPKEYGELPFSPAFDPEDPVLVPTQRIASAHKAWAEKYGIKAQTSTCVNKATWDEERQRWIVHATSHGEKITLISKNLVICIGGGSSTPYLPAWAQPKQVLASQFSGTIIHSKDYRNCHAWAGQRGVVVGTANTGHDMAEDMVKAGMHTTMIQRNPTFVMPVEWLHAGMIADYNQNKDSARADREAFTYPYKITREIIKGTVRQLIDKNPERFDALERAGFKVERYGDIINNIFVRLGGHYVDTGASARIAAGQIKMNTQSIKSLTKDGLLFEDGSELKADLIVLATGFEHNFRKQTEQILGPIADQIDDYWGIDREGEIRALAKPAGHPNLYYLGGDTRMARFFSRFVALLVQAEVFGSGAEPYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A429</accession>
    <name>A0A0D2A429_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_00180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239823.1">
        <property type="nucleotide sequence ID" value="XM_016374547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A429"/>
    <dbReference type="GeneID" id="27327263"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00180"/>
    <dbReference type="HOGENOM" id="CLU_030884_1_2_1"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06178">
        <property type="entry name" value="MFS_unc93-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW19607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="54492" checksum="3821977C5EC75535" modified="2015-04-29" version="1">MASTSAGSDTPAPEIMGAEARPHGKSWMYKTFKIGPVTIPAYATPQFQVVFVALVCFLCPGMFNAVNGLGAAGQVSAHDINNANTAVYATFSVVGFFAGTIANTIGLRLTLGLGGFGYCLYISSILCYNHTQNAGFLIFAGALLGVCAGLLWTAQGSVMLAYPPEKSKGRYIAVFWGIFNLGAVIGGLIPLGQSIHNKSNKVADGTYIAFIVLMVAGFVLSGFLCDPKLVERSDGSRVILMKNPTWKSELIGLWQTLFSDWYIVLLFPMFFASNWFYTYHFQDVNLPKFNIRTRALNSVLYYLSQILGSAIFGFALDSPRFSRSTRARGVMVVLFVLTFVIWGGGYDFQKQYNRAETTADDYVKLDWTDSGYIGPMFLFMFYGMYDSVWQTTTYWLMGSITNNSRKLANFTGFYKGIQSAGGAISPQLDSNNVSFMTQFAVNWGVLAGSLLLAAPVIWTKVKDTTDIEEDLKFSDETIADVAPASAIVGPEGMMAEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4I1</accession>
    <name>A0A0D2A4I1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_00321</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239963.1">
        <property type="nucleotide sequence ID" value="XM_016374687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4I1"/>
    <dbReference type="STRING" id="91928.A0A0D2A4I1"/>
    <dbReference type="GeneID" id="27327404"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00321"/>
    <dbReference type="HOGENOM" id="CLU_001042_9_0_1"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000005">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="521"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="246"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="438"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="676"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW19747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1183" mass="132498" checksum="98AB15DC91802DD3" modified="2015-04-29" version="1">MKIIELIIDGFKSYSQRTVISGWDQSFNAVTGLNGSGKSNILDSICFVLGITNMSTVRAQNLQDLIYKRGQAGVTKASVTIVFDNSDKSTSPIGFEEYGQISVTRQIVMGGTSKYLINGHRAQQTTVQNLFQSVGLNINNPNFIIMQGRITKVLNMKAAEILAMIEEAAGTRMFEDRKEKAQKTMAKKEMKVVEIEGLLREEIEPKLDKLRGEKRAWLDYQKTQSELERLTRVVVAADYVRAGDKMKSANEEHETKRAKVQHLEDNAIKLKREIENLDEDAQRVRSVREKEMRKGGRFQELENRVKELSHELVRLSTVLDLKQSSVAEEEQRKKDIAKNVKNLEKQVADKKKSLEKLQSKWDGAKSELDAQNAEVEKKEELLSTLQTGVASREGQESGYQGQLSEARNRLTTAGTEQEQAKLKISHLEKRIKEDEPRAKKAREQNAGLLKGLEVLRKQAQKLEADLQKMGFDPGREEAMREREVALQKSIRSLSQEADGLKKKVANVDFHFSDPSPNFDRSRVKGLVAQLFTLDKEKSVAGTALEICAGGRLYNVVVDTAETGTQLLQNGKLKKRVTIIPLNKISAFRASAAKVGAAQQIAPGKVDLALSLIGYEHEVSAAMDYVFGTTLICQDADTAKRVTFDPAVRLKSVTLEGDVYDPSGTLSGGSSPNSSGVLVILQKLNEVTKELEKYRAELRELQETMRNEQAKLANIKTVKQELDLKTHEIKLAEEQISGNSSSSIIQAIEEMKASISQLKEDMSTAKTRQEEAAKDVKRIERDMEDFSKNKDSKLKELEKSLVELKKSLTKTQGAIKALQKELQEVRIDCEQAESDLSAAEEQMVEVTNAIDVQKQELNTLREEEASVKSNHDIAQAELADEQAKLTGFDNELRELEQAKSKKSKQISEEALEAQKLGHAVEKAQKDAQAASQLVAALEKEHDWIEDNKDQFGRAGTPYDFQGKNLTESRATLKNVTERFQGMKKKINPKVMPMIDSVEKKETSLKNMLRTVIRDKKKIEETIVTLDEYKKEALVKTWRKVTEDFGNIFSDLLPGHNTAKLVPLDDDINRIQEGLEVKVCLGKVWKQSLTELSGGQRSLVALSLILALLQFKPAPMYILDEVDAALDLSHTQNIGRIIKTRFTGSQFIVVSLKDGMFQNANRVFRTRFSEGTSVVTVMTPGEIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5V6</accession>
    <name>A0A0D2A5V6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240378.1">
        <property type="nucleotide sequence ID" value="XM_016375102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5V6"/>
    <dbReference type="STRING" id="91928.A0A0D2A5V6"/>
    <dbReference type="GeneID" id="27327820"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00737"/>
    <dbReference type="HOGENOM" id="CLU_020336_35_0_1"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051340">
        <property type="entry name" value="Haloalkane_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977">
        <property type="entry name" value="HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="288" mass="32484" checksum="5D4585E79FC1CDA1" modified="2015-04-29" version="1">MYITLPNGIRVFYREAGSSSNPTILLLHGFPASSFQYRNLMLILGEKYHVLAPDLPGFGFTEIPENLNFKYTFANIATTIGSFLDVLKISKFAVYVFDYGAPTGFRLALERPEAITAIISQNGNAYEEGLQSFWDPLRQLWATSDPEQEKKIRQAVSEAVLSFEATKSQYLHGEPDAEKIDDPVTYHIDYALMSRPGNKEIQLDLFKDYGTNVVLYPKFQEYLRTSQVPVLAVWGKNDFIFPPAGAEAFKRDVKNLKLVLLDGGHFLVESHTKEIGGLILEFLAENKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A6C8</accession>
    <name>A0A0D2A6C8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_00917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240558.1">
        <property type="nucleotide sequence ID" value="XM_016375282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A6C8"/>
    <dbReference type="GeneID" id="27328000"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00917"/>
    <dbReference type="HOGENOM" id="CLU_005533_1_0_1"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="195"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW20342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="459" mass="51062" checksum="979A6BCF98077D48" modified="2015-04-29" version="1">MLDPKVEDLEALAQTCLETAKQIKGYLAAQKLPQPTFDQNGPEFFPPVTPEIDGARLDLRAAAKRLYDLVAGPDEVLTWHSYHCAHDLNAFRYVHKYNIPANVPLNSTITYAELASKLSLDPSQLKQMLRQLMAIHVFHEPSPGQIAHTASSRLLTHWGVGSFNHFIAEDTFPMAARVVETLDHFGHGRQEPNRAALNYTFATDKVQYEWYESNPAVRERFSKIMTFMSKAPVMANEHVARGFDWASLPSGSVVVDVAGNMGHCSIPIAETNPGIRVVVQDLPQIIAKARDPATSVVPEPLRARFEFMEHSFFDAQPVAAAAVYFLRMIMHDYSDEWAVRILRPLVRAMGPDSRIVIMDQLMPSAVGVLPYDVERMMRTTDLQMMALTNAKERDEGEWKHLIARAGEGLVDTVFAQTEDKGKGKTLAIRNIQTPPGSTLSVIEVGFVDQETKPGTDGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7V7</accession>
    <name>A0A0D2A7V7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241088.1">
        <property type="nucleotide sequence ID" value="XM_016375812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A7V7"/>
    <dbReference type="STRING" id="91928.A0A0D2A7V7"/>
    <dbReference type="GeneID" id="27328533"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01450"/>
    <dbReference type="HOGENOM" id="CLU_014331_1_0_1"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="607" mass="67150" checksum="1389D9CE2E384C27" modified="2015-04-29" version="1">MALSATAPLPSSPLSSPPPTQSFSKTISTTATGPTYRTAVELPFELSQHVQTYYEEQLFTQAYNFLISIVSNSVSHVDPLKPITIPSPPHLALAATIAVHPVFTTRTYSREKWDQAISALRLLRLVIPLVGPINADSAAAFGFHRYDSRLSRHTSTTGHDDDEDDYHSDNHSVTSTGLNIRYASSQSLFTCCEDFWHLVGWAFNCASLAASSAVHASRWTYYSSLLTFLVDLLERDWSLRTKGPSPTAEESMVLNYIELASGGYTRARRILRAIFADGGTRSTSEFRPIFSHELKEPPKQETKPIAKREDLDIDADIYGDYLMRDESDLSDDDNASTATGTTASGRPAKRLRRAGSRTRTPSAKVTPKTSAGSLRSDYHDGPDDKCFAFLGDTEAVNLRKRLLRLLICVSEHPTMTETSPTTFPDMEELLTLFVEFIKPLPLSAFSEIILSAPSPEGPMPPNFHEVRRIQSQVFEPQTAALLCESLLQRTLENSAPSIRSDVLLSQKKLTEEYLPFAAGKNSIDANARVSVLLEALTRSLAQLGELKREEGLTAAVYRGIEKRMSKVVDAVEGKKQKKGEKRSDEAWSLLVESGERMRRIVDGLQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A880</accession>
    <name>A0A0D2A880_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241193.1">
        <property type="nucleotide sequence ID" value="XM_016375917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A880"/>
    <dbReference type="STRING" id="91928.A0A0D2A880"/>
    <dbReference type="GeneID" id="27328639"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01556"/>
    <dbReference type="HOGENOM" id="CLU_099909_1_1_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16836" checksum="F046353BE3B8B753" modified="2015-04-29" version="1">MPRRTDATTSVANDYGTRPGQLDRAHRLFTLLNHWLHWSSAIIVMSIAAYFISAYHDNTHLVYWVTIGAVDALLYLPALFLPYTRRYKGYLAPLAWFFSYLWLTAFIFSSQDYNFNHGNRGNCDKSPSGVNKCGLKKTLESFAFIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AA25</accession>
    <name>A0A0D2AA25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_02182</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241818.1">
        <property type="nucleotide sequence ID" value="XM_016376542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AA25"/>
    <dbReference type="STRING" id="91928.A0A0D2AA25"/>
    <dbReference type="GeneID" id="27329265"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02182"/>
    <dbReference type="HOGENOM" id="CLU_004542_2_3_1"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238214" description="Probable beta-glucosidase G" evidence="18">
        <location>
            <begin position="20"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="19">
        <location>
            <begin position="728"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW21602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="817" mass="86629" checksum="55602EA4932E3BB0" modified="2015-04-29" version="1">MLVLTALLAALLGDLAVVAQDSDYGSSPPVYPSPQTQGIGWEAAFARAEAFVANLTLEEKAQLVTGTSGPCVGNIGAIPRLGFDGLCLQDGPLAIRQATYASVFPAGLTAAASWDKSLMYLRGLYMGAEFKGKGSHIALGPVVGPLGRTAYGGRNWEGFSPDPYLTGVAVGETITGMQQGGVQACLKHYIGNEQETQRNPSLSPDNVTIESFSANIDDRTMHELYLWPFANGVKAGVSSIMCSYNRLNGSYACQNSKSQNGLLKEELGFQGYIMSDWGGTRSGLASINAGLDMTMPGMHFFFSGDSTASLFGGNITTAVNNGSLSETRVDDMILRILTPYFFLQQDEYPPIDGEEPTLNSRFPPYKYQFNLGASNVDVRDGHGQLIRDLGSAGTVLLKNVDNTLPLKAPTSIGVFGNDAGDVVDGLYSLGGAFGNSDGYEYGTLAVAGGSGTGRLSYLVSPLEAIKTRAAQDGTLVQYVLNNTLLSQPSTLAGVLPVPQVCLVFLKTWASEGADRAGLEADWNSTAVVTSVASYCNNTVVVTHSAGINVLPWADHPNVTAILAAHLPGQESGNSIVDILYGVVNPSGKLPYTIAHNESDYDFAPLLNSTALLETEDPNAWQWNFTEGLLIDYRHFDYENQSVAFEFGFGLSYTTFSMSGIAVQQQGASGAGGGGGPYSSNNNTTVIGATPPPPPSPGKVPPGGNPALWETLYTVTVTVTNTGGVAGAAVPQLYVSLPQVPDAEGHPTPVNVLRGFEKVLLQPGESQTVEFDLARRDLSYWDTNTQQWTIPEGSIGLNAGFSSRDFRQRTQVNVVSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASY2</accession>
    <name>A0A0D2ASY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230054.1">
        <property type="nucleotide sequence ID" value="XM_016386246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASY2"/>
    <dbReference type="STRING" id="91928.A0A0D2ASY2"/>
    <dbReference type="GeneID" id="27339022"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11939"/>
    <dbReference type="HOGENOM" id="CLU_070614_1_0_1"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="7"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="337" mass="37481" checksum="F0A2ADB16CE962E8" modified="2015-04-29" version="1">MAIHNKLEVTVSSDGRVLPEYTAEPEVVEIHRAADGGNAPTIIKYIESTPGLDFAINFKLLKGIDFGEADQINFITYCDGQSMGGRAATRSQYELTGSLSLTRNSMKVQGDNTTTRRFYWKELTTTDEEPPTGSQGFEKYGQLGTIKVKVWRQKTYFRKESTHATTHKPPTLVEDPIPEKALKGRAIGATIGLGPALPVPGKTSKRTVHANVIDSGPLVIFVFLYRTKRDLQILGVIPRTPSPEPLERRDVNTLSVEELKELVGRQQAELTLSRQAVESRVKKERGSKVKTETASGDDNDTVISGMKREFQDEDDDIVFVRSQKKPHREPEILDLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT45</accession>
    <name>A0A0D2AT45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_11994</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230109.1">
        <property type="nucleotide sequence ID" value="XM_016386301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT45"/>
    <dbReference type="STRING" id="91928.A0A0D2AT45"/>
    <dbReference type="GeneID" id="27339077"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11994"/>
    <dbReference type="HOGENOM" id="CLU_008999_1_0_1"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="345"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW09893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="869" mass="95569" checksum="BBF2C71CFE8CAFA5" modified="2015-04-29" version="1">MKCHAQKSDKIAASKPAASRRNTISEGVAPQTARNEFDINSPAAVANGPHTGIPLMQILSPTNYHPPQGNESTQPSRHSLDLSTPFLDPTTSSNPLNLGMSSTTWTVPSPISTMNKMSQPPAPQKQSPSQNSGGNTSTFETSVTTPGNPVQTPRSEMAPNHFADNHIEWLPPSDPDQSNFHDPFQMWLFPSLGDLDQSPDFLQTYGLTDPSQQFADPKDLTSGRTYEHADRLKTIDKVPRERFSRVQRCWGPRPGRVHRIMPILWKEVASLHLDNIFSESPTTADDFRTTSNWGLDIDCRVRLRDAFRTPAPSVYHSPKIPPIVDPSLVQGNEEFPPAEILDIALGLFFRRFHPTVPFIHMATFSVRTTPSPMLFAMCLIGLSILGTTGATKFVAKMFPSFLQRVCNDLSVCAATSASPTQQLVVFATALLTLNLSVVTGDRDSFNQSQMLYVSLISMAQQNGLFAAGDGQSLDALLSEMSESDDRWKVWSRIESAKRLILGLLLVDSWYSNLLSKAPIIRSESVCVVAPCDEALFQAKSATQWQSLLRSGKSQSAPRFRIEDLHKHDMQPTAGQLGYLGRSSLLALLQIQMLEAYQRLMPPDQLTIGSFIPWHVYAGDVRARTLIPAVLASGAVAGAAAGRSSSPNNNTTTDDTNCTVLWHSLCVMLLSDFRMFELAAGRHGAAPATGALESIGQWSQTQSARRACVHAAQNFRLMSERRVSDNVTIHSVTALFASALVLGLYLFMVQPGPASRQGTAPVELIETDPDWAEMHDLGFRDDSLDGHHAERNLTANREDEQHFSLVYQFVKHGGTVSLNGVVHQGGYESARRVLLDFANLMDGISGRRLRTFTQVLHIMSDDLMNVDPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT52</accession>
    <name>A0A0D2AT52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_12038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847504">
        <property type="protein sequence ID" value="KIW09695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229911.1">
        <property type="nucleotide sequence ID" value="XM_016386345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT52"/>
    <dbReference type="GeneID" id="27339121"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12038"/>
    <dbReference type="HOGENOM" id="CLU_1917083_0_0_1"/>
    <dbReference type="OrthoDB" id="4157201at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="132" mass="15060" checksum="7099C2444AE1BEAD" modified="2015-04-29" version="1">MSSTTGTVTELYSPSPLKIAPNVDVLLHQVDQLQNSVNSDVVERLLEENAWLEHSIDRGKEKWQSTTKLLREAFEAYVVLNACIEQLEQETRELDEKWAGDFQKQLSETSPPELSYQKASLYSPVAQDLYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATU1</accession>
    <name>A0A0D2ATU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_11114</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230369.1">
        <property type="nucleotide sequence ID" value="XM_016385425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATU1"/>
    <dbReference type="STRING" id="91928.A0A0D2ATU1"/>
    <dbReference type="GeneID" id="27338197"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11114"/>
    <dbReference type="HOGENOM" id="CLU_001042_0_1_1"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="542"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="193"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="409"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="726"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1054"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW10153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1256" mass="142981" checksum="2BDAD6E8D086C26B" modified="2015-04-29" version="1">MGKLMRLELFNFKSYKGHHVLLFGDAYFTSIIGPNGSGKSNSMDAISFVLGIKSSHLRSTHLRELVYRGRVLRKSTANGEQETNGSQEHDDEEGSQANGTQGRNDPKAAWVMAVYEDDAGIEQKWKRTITNQGVSEYRLNDEVVTAQQYNEALEEENILIKARNFLVFQGDVEAIAIQKPQDLTKLIEQVSGSLEYKADYDKLKAELDEAAEQQAFQLNRRRGINSEIRQYQEQKREADNFQKKASERDEAIVTHVLWKLYHLQRQIEESSAEIQKHQSDLKDFRRGIEKYERNLESAKKDHAQAARGVGKVEKAIKAKEKEIEDKTSSLVPIDEQISVSNKQLTKYANRVNSIQAERNAQASTVAQLEKDLARVEKAQALWQQQWEQNASRLGGQLSDADLQQYTRLREELNRRASADLSRIERLKSERAPIEATYNNLKNSVNSTEYRLQSLENEYKTLSERRDTIKEVVTNTQTEIDGKKKELHAATSRRLQAARTRTELDEKLAEVARKLLEADDGRRTSEKELRMKETIAMLKRTYPGVKGRVHELCKPKQKKYQEAVSTVLGRHFDAVVVDTEATAKQCIEYLRDHRSGQATFIPLDTIQVKALNSNLKGMHRGMRPAIETVDYDQSVARAISFACGNAIVCDDLNIAKELCYARHVDAKAVTLDGSVIHKGGLMTGGRGREQNTRRWDDAEVERLNKLKDKLMDEFAALPQERSRVAEEQTLQTELSGLEGRLRFAKEELDALTKNLQSKKREIDHVKQQLNEERPKMLAEQRKLEKIDEDISDYQESVHNVENEVFADFCQQHGFDDIRDYEARQGSLQQEAAQKKLEFVTQKGRLEGQLSFEKSRLQATDDRLEALRDREQRDKEIIDELNEQREGIQDDLSALKNELDELHAQLDEQKELLSNAADALAKQKQEVQKRSKEMESTFRAISALEGEMQRHSSARYSLLRRCKIENIAIPLADGSASLDSVPINDLPLEDGDAMDVDEDDPTSAALKAHSVTDYGIIPDFDALDDELKEEDNEAMESKLLDDIAKLNATLEKMQPNAHAAQRLATVEARARDTEQEYEESRAHYREVKAQFEETMQKRNELFHRAFSHISEQIEPIYSNLTKSEEFPAGGRAYLTADEDEPYLAGVNYHTMPPTKRFRDMEHLSGGEKTMAALALLFAIHSYQPSPFFVLDEVDAALDNANVGKLVNYVRNHAGPGMQFIVISLKTGFFQGSEALVGVYRDQSANSSKTLTLDLRKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATV4</accession>
    <name>A0A0D2ATV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_11129</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230384.1">
        <property type="nucleotide sequence ID" value="XM_016385440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATV4"/>
    <dbReference type="STRING" id="91928.A0A0D2ATV4"/>
    <dbReference type="GeneID" id="27338212"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11129"/>
    <dbReference type="HOGENOM" id="CLU_025144_2_1_1"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW10168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="596" mass="66912" checksum="2DF840A209029C79" modified="2015-04-29" version="1">MKTPCAPSRDLLRFLRTQANSVFITPIAPTRPPHCRSLSTSSRCSRLQTSSHDDIWQRHRDSCKALPAPRCAPPGPLQARNASSGSHSPGFWLRWFRRKQAAARSKLPPDPPGNSSNYDETSAQLFNLSRSLSRNQTGADLKLRCTEFDANGSVTMVAGEFKKSELIAKYGLLPRDLRKLDSSVLPHILIRPTAILINLLHLRVLIQSDRVLVFDAYGSTDSYTQSLFMYDLEGKLRQKPDPRNKSTYLPYEFRALEAVLISVTSGLEAEFALVRDPVVHILRELEEDIDRDKLRHLLIHSKKLGTFEQKARLVRDAIDDLLEADDDLSAMYLTERKVSNTPRPEHDHQEVEMLLESYHKICDEIVEISGNLVNNIRNTEEVVKAILDANRNQLMLLEIKFSVGTLGLAGGTLIAGLYGMNLNNFIEETDWGFGAVSVVCFALSAVISVYGMRKLRKVQKVSMWGEGLPNTMGHRARIGGRGNWHSEAFERQAQRPIRPKGGGINLGVKQSDPVYWPGMEGLGAHRLQATSTNSFRPGDTADTNGMAQQPQMTIQDDVEDVEAKWREDSKKQKGLMTKEQQAHLRRASTHHTHGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AX48</accession>
    <name>A0A0D2AX48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231504.1">
        <property type="nucleotide sequence ID" value="XM_016384902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AX48"/>
    <dbReference type="GeneID" id="27337671"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10588"/>
    <dbReference type="HOGENOM" id="CLU_004495_0_3_1"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="62508" checksum="D461D97E83CC6D44" modified="2015-04-29" version="1">MVAATDSDKLAEANGPAAPPSAGPPSERRGSLTLGLDPALASEEDAAVLAKMGYKQELRRNFSMVEVFGIAFAIMGLLPSIASTLSFSIPAGPVGLVWGWFLASMFIFVVGLAMADLGSSMPTSGGLYYWTHYYASPKWRNMLSFIVGYSNTLGLVGGLCSIDYGFALQFLSVIVIARDGNWTPTNGEIYATFLATVVCHGVIASTMAKVMGKLQTVFVVMNFVLIFATIIALPIGAKDSRNSASYIFTHVENLTTWPSGWAFMLSWLSPIWTIGGFDSAVHISEEAANAVKAVPFGILFSIGSCWLFGWICCIVIAACMSQDLEHILGSPFGQPMAQIYYDALGKNGALGFMSLLMIVQFLMGVSILVAASRQSWAFSRDGALPFSSFFRPISKKFGYIPVRTTIGCAVLAAVLGLLCLIAPAAAAALFSLAVAGNNLAWGTPIFCRVVWGQKKFSPGPIYTGKLSVPIAWLAVLFLIFGTLLAMFPSGGPNPTSETMNYTCVINSAVWGGALLYYAVDARKWFRGPQITIDLDQLTEAQEQALRDEGVKIEGEGAKAVVGGRGGSTASNVPVESDLGVSGEESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXA2</accession>
    <name>A0A0D2AXA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_10309</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231226.1">
        <property type="nucleotide sequence ID" value="XM_016384624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXA2"/>
    <dbReference type="STRING" id="91928.A0A0D2AXA2"/>
    <dbReference type="GeneID" id="27337392"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10309"/>
    <dbReference type="HOGENOM" id="CLU_022477_0_1_1"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="24"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW11010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="476" mass="52407" checksum="2CCCEA110FECF235" modified="2015-04-29" version="1">MGSTTNSSYALSEAHKDMLEKSLVESDPEIAEIMKKEIKRQRESIILIASENVTSRAVFDALGSPMSNKYSEGYPGARYYGGNQHIDAVELTCQARALKAFNLDPEKWGVNVQPLSGSPANLQVYQAIMRPHDRLMGLDLPHGGHLSHGYQTPQKKISAVSTYFETFPYRVNLETGIIDYDRLEENAQLYRPKCLVAGTSAYCRLIDYARMRQIADKVGAYLIVDMAHISGLIAAGVIPSPFEHADVVTTTTHKSLRGPRGAMIFFRKGVRSTDPKTGKQVLYDLEGPINFSVFPGHQGGPHNHTITALAVALKQAATPEFRAYQEQVVKNAKALENEFKALGYKLVADGTDSHMVLLDLRPQSLDGARVEAVLEQINIACNKNSIPGDKSALTPCGIRIGTPAMTSRGFGEEDFKRVARYIDQSIKLCKQVQGGLPKEANKLKDFKAAVASDTVPEIQKLRQEIAEWSSTFPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYU2</accession>
    <name>A0A0D2AYU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_10896</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231811.1">
        <property type="nucleotide sequence ID" value="XM_016385209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYU2"/>
    <dbReference type="STRING" id="91928.A0A0D2AYU2"/>
    <dbReference type="GeneID" id="27337979"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10896"/>
    <dbReference type="HOGENOM" id="CLU_009240_1_0_1"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00306">
        <property type="entry name" value="Peptidases_S8_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="DUF7580" evidence="10">
        <location>
            <begin position="157"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="591"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="531"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="597"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW11595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="886" mass="99532" checksum="2BB8FC9E9E19070A" modified="2015-04-29" version="1">MALYDLWDAVQDFTSKLSHLILPMVNRTDPKQRDVNLGLLAGTMLTISSSLTIPMPLHAELSERLDNLLDHLEAICLSPKEPSVVDTRQRISALRSALSPLDARRGSLKRHLIEFASQPLERFKEYMNDLKDCAPNIDDEIEHVFQPLALPDHSQDYPMQVNRSLYTVLKQHSGCTCTGINSSVAGKRHQARLQLTLTCPTDGADIAFNTLFSRSSVACDGDATGYAWQKLQFRISRPSVRFKDDSVENDGFRRPMEHGEASTCIDIGQFCSLLRKDYGRGRVRLRIQDEKLMQLYEPDRELDEHSKFVTNSPSISLAELLQVQGMTAKNKVLLAYIIARSVWQFYNSDWMRTQWSTDRIHFVQERPVADRTRQMLDPSYPYLTFAFDSEATSDAPVEYCTEDSIYHRYPLILALGIILIELCQRTPADKSAYDEALGTKINTDYFYGQESLESESWPDLDLNLEAKRTYKNVVKACLNHEVFTQTAVADIKTRRETLWEVAVCPLARLAAKLGWLWLDNGSIRRLATERTPVHKTEKKEESLVLPTSSKRSSSRQVPRSVSADSEKWLDAVKFSDLNIELVSGFQDVPRVKVAVLDTGYDPASIFFSEPERKIRIQRWKDFARRLPNQTKSAREDNDGHGTHVLSLVMTIAAAADVYVARVTQGRTARDLHEACDSIAKAIEHAAVKWDVDIVIMSFGYSETQPPIETAILRALLHKHGRILFFAGAANEGGNSLEMFPARDDHVIAVRGTNEKGYPQEFNPPPSFSGPDCFMTLGKDVPGAALRRDGGGTVLRSGTSTSTPVAAGVAAMVLGYAKIHEVELKRVLSPERLAKLHTKGGMRSIFLAMSLEITPKCRYVNPHNFTDATHDERLTMIKSALLHDSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2C1</accession>
    <name>A0A0D2B2C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_08200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233229.1">
        <property type="nucleotide sequence ID" value="XM_016382526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2C1"/>
    <dbReference type="STRING" id="91928.A0A0D2B2C1"/>
    <dbReference type="GeneID" id="27335283"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08200"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="46"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW13013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="338" mass="37763" checksum="A64083B321BA3199" modified="2015-04-29" version="1">MLSRVQIRASSRMSQLSRQLSGQTRTMAGYNKTKFQLNTGDEIPAIGFGTWQDKEAQEDAVYEALKAGYRHIDTARIYGTEPGVARGILKSGVPRSDIFITTKLWNNSHHPDDVEVACNASLKDLQTDYLDLYLMHWPSPFARGDKLMPQQDGQIVTGDTDYVDTYKAMEKLVKSGKCKAIGISNFSQAELERLLGETSIVPAAHQVELHPYLQQPDFVAFHKAKGIHITQYSPFGNANPIYDKGRNIGKLIDDHVLSDIGRKYGKNGAQVALAWGIAKGHSVIPKSKTPARIQANFEADFKLDAEDVKKIDALDKKLRFNDPSQRFGWDFYADLDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B319</accession>
    <name>A0A0D2B319_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase 19.3 kDa subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_08177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233206.1">
        <property type="nucleotide sequence ID" value="XM_016382503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B319"/>
    <dbReference type="STRING" id="91928.A0A0D2B319"/>
    <dbReference type="GeneID" id="27335260"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08177"/>
    <dbReference type="HOGENOM" id="CLU_055737_1_0_1"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="5">
        <location>
            <begin position="125"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="256" mass="27929" checksum="DD8604BFECB5B09F" modified="2015-04-29" version="1">MSLSRSVAPRALRGAQQTIFRASDGQPRSTDKLPFVATSTVPFSVVRAASISSSSKKSATSLAPTTPGTNDPSRLPVTGGVRREVPLPSQEKKEGAMQYALTTLDQIANWARQGSLWPMTFGLACCAVEMMHLSTPRYDQDRLGIIFRASPRQSDVMIVAGTLTNKMAPALRQVYDQMPDPRWVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTSEALMYGIFQLQKKSKFGVFPLQPEPKTKSMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B362</accession>
    <name>A0A0D2B362_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08551</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233579.1">
        <property type="nucleotide sequence ID" value="XM_016382876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B362"/>
    <dbReference type="STRING" id="91928.A0A0D2B362"/>
    <dbReference type="GeneID" id="27335634"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08551"/>
    <dbReference type="HOGENOM" id="CLU_037460_1_2_1"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="279"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="387" mass="43405" checksum="5B572C40FF490689" modified="2015-04-29" version="1">MATSPVAVVCVGMAGSGKTTFMQRINNYLHVNKKKPYVLNLDPAVLNVPFQPNIDIRDSINYKEVMKQYNLGPNGGILTSLNLFATKIDQIITLLEKRANPPPDSKIVPPKHFLVDTPGQIEVFVWSASGSILLESLASSFPTVIAYIIDTPRTSSTSTFMSNMLYACSILYKTKLPMILVFNKTDVQDADFAKEWMTDFGKFQEALREEESKGVFGGEGFGGSGYMGSLLNSMSLMLEEFYSHLNMVAVSSMTGDGVDDFFQAVEEKRKEFERDYRPELEKRRKEREAESAAKREHDLTKVMRDMNVNPRPKASETSVPKAEESSDEEEEEEAVDGDEYPDAERDDEDDEGLKRRYTNTLREQGIVVDDDDPAVAQMIAATKRAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3G1</accession>
    <name>A0A0D2B3G1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233401.1">
        <property type="nucleotide sequence ID" value="XM_016382698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3G1"/>
    <dbReference type="GeneID" id="27335455"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08372"/>
    <dbReference type="HOGENOM" id="CLU_125054_0_2_1"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="104" mass="12047" checksum="3B5468F794F64FA2" modified="2015-04-29" version="1">MRPSPVLRALRLTLFTRPDCGLCDVAKARLMEVRQQRTVDYSEINIDTPEQKQWKNVYDYDVPVLHIDKDVSRAPTLNAAKKLMHRFTTEEVTKAVDEVEQATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3N6</accession>
    <name>A0A0D2B3N6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233506.1">
        <property type="nucleotide sequence ID" value="XM_016382803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3N6"/>
    <dbReference type="STRING" id="91928.A0A0D2B3N6"/>
    <dbReference type="GeneID" id="27335561"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08478"/>
    <dbReference type="HOGENOM" id="CLU_060131_4_1_1"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF17">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_8G05690)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="219" mass="24609" checksum="0B7D7AC4BDBCE8E4" modified="2015-04-29" version="1">MPAFVLLPASPSDLERIAQLQFESFASDHGFPVIFPKGASPTSLTHFVHSFENDMENDPTCFIMIVKEAMSSVIVSYAVWHFYPPKSQDEIDMEMLVENIPLPADANQELGNRLIRESIRKKHEVVTAAIGPQKPYAFLAALGTSPQYQRQGAASLLMTWGVERADDRGVAIYVEASPDASRLYEKHGFHEVSRLRLDMAPWKEGDYFNTCMIREPTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5M9</accession>
    <name>A0A0D2B5M9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234459.1">
        <property type="nucleotide sequence ID" value="XM_016381357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5M9"/>
    <dbReference type="STRING" id="91928.A0A0D2B5M9"/>
    <dbReference type="GeneID" id="27334108"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07025"/>
    <dbReference type="HOGENOM" id="CLU_000288_125_15_1"/>
    <dbReference type="OrthoDB" id="4161490at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="171" mass="19328" checksum="E67C538F4A0F7E4D" modified="2015-04-29" version="1">MTLLEKVVRIKGQSLAEDHPSRLVSRHALAIAYEANGQVKEAVTLLEEVVRIEGQTLTEDDPSRLASQHALAEAYWENGQVKEAVTMLEEVVQIREQTLAEDHPDRLASQHNLAIMLWSLGQHSAGLQLMRHVVDIRQRVLDPNHPRRKVSEGWLQRFEDESSESGEVAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5Q3</accession>
    <name>A0A0D2B5Q3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234479.1">
        <property type="nucleotide sequence ID" value="XM_016381377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5Q3"/>
    <dbReference type="GeneID" id="27334128"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07045"/>
    <dbReference type="HOGENOM" id="CLU_485738_0_0_1"/>
    <dbReference type="OrthoDB" id="5239669at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="561" mass="63158" checksum="BE528C0CD27483D4" modified="2015-04-29" version="1">MAYPGPSSDANVNAPDEIEDDNMSNEEDSAEDWMSCDRRSWGSNSQMSFRSDSPDEAESPESMNAQETIPILPFDKEYIPPEDCWSEMGASDMQEEEEKELDDEAMHELAELERDVQAKRRKLLKELNATASVPGLEKMDKLTLAGVDGKMNVSRNEEITESDDEGDSESDSENNSKSACKDLSKPDAVGWESAADGSRLLPEAIESILEFFKERPHLNRAECEEYCLKTYLMMEGDGPSEARERQLNVHAYPSESQFRNSYTVEIIDTTVTNPDLMTQFYITPESLDEDQLAQAKEAYGDFVPQYTYVGHMGMVPEHPAELFVWRIVSPAGRPIAANRYRLGLRVNQDKYVGILKQFVDLVCQPLRLAGGGGRLHDEKDWPQVLHNHLLDVFNIIVRPDWSGIACVLLWGAPPSMTLPFGASLCGLLFLLEGGPEDGNPISKANPSLFGTYSHEARELERLCMYYLQEKIPALADDPQAWHRLFGAMNQGIETAADWGEEVDRIGYQKQLDELRWDWFQWETKADTPKGSAVVACAESGRGGEKGDMNMHMDMDMDMDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7G0</accession>
    <name>A0A0D2B7G0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234821.1">
        <property type="nucleotide sequence ID" value="XM_016381719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7G0"/>
    <dbReference type="STRING" id="91928.A0A0D2B7G0"/>
    <dbReference type="GeneID" id="27334472"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07389"/>
    <dbReference type="HOGENOM" id="CLU_047725_0_0_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34318" checksum="81D0026549DB8694" modified="2015-04-29" version="1">MGLSMLLPPEPIDPAYQPSTSIAKIPANAPIEDILEIIERDGGVILTEFTSAEELAAIDRDVDAHRKQTRAEKGALPQIPKETLSVAGLVGKSPTVARMCEYPVLEKLRTAILQEKFDVIREDYVDRNIIEPLLSISLTFYIGPGAPRQRLHRDDNTHGTRHAGEGSFDLKRAGQFACLVAGSKTTRENGATMFIPGSHKWDDTRVPRIDEVCFAEMEPGSALIFLASCYHGGGHNSTKDEVRRVHGLFFVRGTMRTEENQFLAVPRSKVLTMSDKMLSLLGYKKPTSALGIVENEDPASNLRTFLDMASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9M3</accession>
    <name>A0A0D2B9M3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GS catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235556.1">
        <property type="nucleotide sequence ID" value="XM_016379729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9M3"/>
    <dbReference type="STRING" id="91928.A0A0D2B9M3"/>
    <dbReference type="GeneID" id="27332469"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05386"/>
    <dbReference type="HOGENOM" id="CLU_017290_6_3_1"/>
    <dbReference type="OrthoDB" id="3364440at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383:SF2">
        <property type="entry name" value="AMIDOHYDROLASE 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383">
        <property type="entry name" value="NODULIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="3">
        <location>
            <begin position="647"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="978" mass="109995" checksum="C4C6FA29552F9E98" modified="2015-04-29" version="1">MAPMSELYPTLHQVRELESAGIQDLQEIVQTFPIIDNHAHNMLTEDNAFGSAEYPFESITSEAQGHALTDHVQTSLAHIRGIKHLAEFYECAETLQDVKAARYEWVRRDYPGLIKRCFEGTHAILMDDGLLAEIIHPFKWHRQFVPTVSRIVRIEAVAAELLEHLAHAAGFMRVGLDADWDISQTESFLVRFNTVFRNQIRTLANDPDVRGFKSVICYRTGLDIGLESRKNFRPHQSLTDSVLLQSFHHFLQKAVRDSKYRIEQKEVNDFLVVAVCDVLEKLVDTDGENLPFQFHTGLGDNDINLIKANPAYMQPLIEAFPQVDFVILHSSYPYTREAGYLAANFSNAWLDIGEVFPMLSRDGEESVLRQALELTPASKILWSTDGHFYPETYWLANKHFREALEKVLTAYVAAGDVSVAQAIEIAVDIMFWNSNTLYKLDEERKFPELLRACGRETVDSMRTLVNGGSKAPSFRSTASTTVATPGIPSARPGYSSNSATLTATNQNLAIRSTSISAPSGQNATAVLAQNLTHFDAFLQTNPSVKYIWNQYLDYTGTLRNRMVTTQQFRKSLATGKYLACTTALSRLLQDDNGATGVSATGQFILTPDLSTLSLNKGISSPSATVQTWWMLEPDHNNLSLSHWDRCPRWLLQSQCEALKSEFNISVLMGFELEVIFMRPIYNEERTDFKDFAPLHFVHSWSNMTYQQLDMLPMIEEIVEMLAELDIHVPQFHSEAAPGQWEFPLPAFEPVKAVDIMYKAKDVIRNVAKKHNLKATCYPRPFTFTCGSANHAHFSINGPGGTLERCEGPFLAGVLEHLPAILAFTLPIEESYQRVGAGIWAGGEYVCWGSQNKEVPMRKCEPGHYELKTIDGIGNSYLSMAALLASGLHGLRQDMRLEHKDCTGDPTAIGEEERAKLGISVKLPDSLEKSLRALDRDKILRRGLGYAAVDDYLATAESLMQKLRGFGDEKRRVWLMARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9M8</accession>
    <name>A0A0D2B9M8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235884.1">
        <property type="nucleotide sequence ID" value="XM_016380057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9M8"/>
    <dbReference type="STRING" id="91928.A0A0D2B9M8"/>
    <dbReference type="GeneID" id="27332800"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05717"/>
    <dbReference type="HOGENOM" id="CLU_577511_0_0_1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="403"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="473" mass="53617" checksum="937AAEA9F7FCBAE6" modified="2015-04-29" version="1">MSGAESQRENQFSYRLQLWNLRKNWTVPSRAPRRKEPQGEATDFSVAVRELQSGAIDRDTRRCEATAQAVNANVSPPLPGDTLIRTPSPRSRQRVPQAANPHGGNCSIETSARIIPALTYDLPTTPFEPTYRAETPSLPEHPPPGAVRTWLFDDDDRVQTCQARHTPRASNAPPVPKATADAARHSHPSLQRPRMTSLLQCSYPLAVLMSQRHLRRHSPPGGRLELTGTPDPDVLSKVVDLLGWLQLSPEVVEMGTSHFSYLPVRFTFAYGSRGWTELLVCLKFAHIALSDEDLMDYRWKDVFSWCVPNDSFSDFCFLECSLLVERSFCLWKFEDQARAYRDPSHASGDSILDSMTPTFSAITELPNTLPTTETLPLPENLPTAATMPMIVTLPTSEHRMLPEKSWELHKHEICQLYLTHTLDKVAQIMEERHGFRASIRGYRRRLAAWGSKQSDVEDFAGSIRLWKRPRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBV8</accession>
    <name>A0A0D2BBV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236311.1">
        <property type="nucleotide sequence ID" value="XM_016380484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBV8"/>
    <dbReference type="GeneID" id="27333229"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06146"/>
    <dbReference type="HOGENOM" id="CLU_677985_0_0_1"/>
    <dbReference type="OrthoDB" id="3558144at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="45457" checksum="7BF0667B62F15B59" modified="2015-04-29" version="1">MHWDTSAMGLEVDGALPDVETFDWSSLDLDGTFSAPGDYSDQIVEEPALQPLLGDTSNSGKKTAIHGTNDNGTVIAKSVVRKPQVRQKQDEKTTSSLERRRAQVRLAQRAYREREKGLVTSLRQDVDDLRARLLGMQSIADDWFRLISSMPTLSEETKQLVERLWKNESCHRLSLPSNIIGNNLAVNHDRRTRSTNQFKNSATYPTPFSLRLRIDTLKGAHRLISDPGTPCTILVDKFRNCIFVSTREEIKQRLEILINGSDDVPEPPRYTLSQPTNEHWLSESSIHNPKIDKPDNLREDDTYIDPSGVQKYLAGKGLALDQTSSYAEFSAKPSIMEGSSLSKRLTVFDELCQNQKVMVNINKLLRAIDNCMELELAARMVCRWTGPGILTSGIDEAVQSTLLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BC36</accession>
    <name>A0A0D2BC36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236406.1">
        <property type="nucleotide sequence ID" value="XM_016380579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BC36"/>
    <dbReference type="STRING" id="91928.A0A0D2BC36"/>
    <dbReference type="GeneID" id="27333324"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06241"/>
    <dbReference type="HOGENOM" id="CLU_012058_0_0_1"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="271"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="502"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="570"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="657"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="966"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="975"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1013"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1028" mass="113982" checksum="2E63C44C5CA780BA" modified="2015-04-29" version="1">MHKISNFTGQARHGWERMTPAAFGMSRFHQDMSTPQPLRRPQGPPATGSADLTPVNLSFNVPFASYLAGPDPDDILHSSPGAFQRWTFPADTPEGTPIHQLPVHIQNEERLRSLCTYISDQSGGRVQATVTSSEPKAGPALHRKSQGLVTNVCISGEGELVYKMRSKILNETPIMMRPAIVDIDPGLILDDGETGVRSSVLNHIDLCAKYTGTDIFLLKPKNGEASSTAASYGNGVDSGLDQRYRVNIFGDMESVEHAKTRALMMIDQILKHKIDVIKLEVTMHTLVSGRTGKNIKMIESATKTAIYFPPPFPGVFGYIPPHATRRAADEIFITGENQERINQAKQKLKELVMGIKLYSKDAVVSASKIDNILLDRLDKVRKIMETNGSHVLFPQLASQRGIIRVQGTEVLHVERTVKEIMALAGQFFSASWWIIMPDPSQGPAIRAPSPDDIRIMLSDICTNSGAEISFEKFTFTINGSDDAVKAAMMVINQIPFVKRTPYQIRVKIELANEHKEFVSGKKNGKINKIMGQSNVQIIFDGFNEYNFYIDVVGSQYEATKNGLDLVEQEMPASISFHVPDQYHKRIIGIGGQHIQRIMKKYSVFVKFSNAMDRGGVGKDDDDIKVDNVICRTPARNAQSLDLVKQEIMDMVEKVDAEFVSETVVINRLYHRELIARLSEIEDLEKKWNCKIDFPNTEQASDIVTISGPEYQVPQAVDAFLGMVPESHEIAFQKAEDLDTFFSTAEFYTDLRQKLRDQYEVDVHANPELSSLPKSATASVERIVGPSEGRLVLTYTRNNAGGLKDAIDYLISQLVPHGLDATTVKGAIPRPKSDSFEDSLPFFDSKLLQNAPSLHSTDSPTRLSFADGEHTPVSERASLFDRLRKPGSISSFSSFMSRKNQNNSPGTFFKHASSNASKASLISMESRESGYRNFWNDSGVNLPEEDVSASSLSAGWPSRYENKFPFGTGTSVSGDRTPKHEHPRASFDSGRPLTSHSFSSYQGPMGPQHHNPMLTGTNGSANHLNLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCE6</accession>
    <name>A0A0D2BCE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_03841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236869.1">
        <property type="nucleotide sequence ID" value="XM_016378192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCE6"/>
    <dbReference type="STRING" id="91928.A0A0D2BCE6"/>
    <dbReference type="GeneID" id="27330924"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03841"/>
    <dbReference type="HOGENOM" id="CLU_022885_2_0_1"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18497">
        <property type="entry name" value="BACK_ABTB1_BPOZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000248">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000183">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="368"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="601"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="686" mass="76449" checksum="14785BC58745B38E" modified="2015-04-29" version="1">MSANGLLRKDQLERSLHDEKKLIEEGILKEDNPLDFSENFQKLCSACRRGDLKVCQEMIQEGTNINAKDQYDYTPLILASLCGHYEVVQLLLESGALCERDTFQGERCLYNALNDRIRNLLLSYDYSKSTDPLQPLASHLISLLTREQPKTSDISVVTTLESFHLHKFILSARSPYFRSKLSAAPDTTSWKLPSTIPPQSLGIALKHLYLGEIPRELGGGPGTGFTDSEVLAGVDRISKHLEIQNLSQLILDSSDRRLARQRRQDEVEKGRDQLEQWFRENVLKHAIETDTSRADSIKWDRDNGIFADVLLRADEDEPEEEEEATNGTVDDLTRPRTTSTNALGIPLDGPPSRNSRASSPSRRPRRCKIYPCHKAMLIRSEFFMTMFDSPFREAQHTPHLQIVPIDCSPQVLEIILTFLYTEQTNFGLDIAVDVLFAADMLFLEKVKAKAALVISTLGNGTATAMAPDGPTREDEDMDIYEILRAAWLTRVQRLEEFAARYIAYRLEAFIDDPEFADLVKESAGRISARQETDSIELLDDIRYYLSERFRLRFEDSGLEDVMDEEAAMAAAAANALPNGPPVEDGFVAETTETVAAAAQSAPQAPKALGGMSPSQSQQMPADEGVDMSPPENAKVEEATAESLLQSGAVRTLDGELAGDEFAADAVNYQILLGKIDSLLERLKLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BD02</accession>
    <name>A0A0D2BD02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237064.1">
        <property type="nucleotide sequence ID" value="XM_016378387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BD02"/>
    <dbReference type="GeneID" id="27331121"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04038"/>
    <dbReference type="HOGENOM" id="CLU_035756_0_0_1"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF7">
        <property type="entry name" value="PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0268928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="6">
        <location>
            <begin position="155"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="6">
        <location>
            <begin position="239"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="6">
        <location>
            <begin position="366"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="464" mass="52514" checksum="C92C397AA505BF58" modified="2015-04-29" version="1">MGAGAFLEPLVVVGLLFGGAWINRATDSTVSARDQFWNESLPEARGIETDEALDIEDARISRSKRSLSPSLLPSQENRWREREVRVMGYHTVLQTPNTAVFRNRLLSRLLHKFPFLVEAWYWALIYWVYQLGRAFTALTVVEGTVHVARRHALRVIAWEQRLNIFWEKPIQDFFMSFPRLMMCINWLYSFIHIPGTIAFLVWLYYYTITSNQGVYRRGAGAQDIITQGRHGSAAGSGLYEARRRTMAACNLLAFVVFTLWPCMPPRLLSDPDYSGPDAELAKSFGFVDTVHGKDGASSVWTQNKFCNQYAAMPSLHFGYSLLVGLTIMTIPLAPQHRRSRSIHLPLFNNSHPELAPQIRLPSTRRLACLTIGFMYPFAILIAIVSTANHFILDAVAGATICGLGWNMNRVLLNLLPLEDWFLWAVRIHKPVHVSLQESRGIKPGLLKNSMGGWVPERPVVVDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE23</accession>
    <name>A0A0D2BE23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA mismatch repair protein msh3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_04035</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237061.1">
        <property type="nucleotide sequence ID" value="XM_016378384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE23"/>
    <dbReference type="STRING" id="91928.A0A0D2BE23"/>
    <dbReference type="GeneID" id="27331118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04035"/>
    <dbReference type="HOGENOM" id="CLU_002472_4_0_1"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001238">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000010">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="857"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="980"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="588"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="980"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW16845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1006" mass="113306" checksum="D83CE5A76B5688EE" modified="2015-04-29" version="1">MRPGLRAFRSRDLRLFESASRHYALHSLQRPCLRPPNLWLASWRVSDRQQRGAKTTTRRKVKDLQQGAIQGESLPELPSDDEPQYPALLQGVKNNMARFDNCVLLTRVGNFYEMYFEQAEEFGPLLGLKVAYRQTKLGPVAMAGFPFFQLDRFLKTLVQDLHKYVAVCEEFLVNVSGKVKSGGLKHDRQVTRVVTPGTLIDEKFLDPYENNYLLAIHPEFHSSSKCDGDDNEPKVGLAWLDLSTGDFYTQTVLRSALSSALTRISPREIILPSDVSQDVQEEVQTIVGHDHRLLTLHQTRTGFLSMKEWSSMLVTEMQDGAENAFQEVEKQAGHCLLDYVQLRLQGLQLRLQPPRHIELYEIMGIDRSSLRGLEILETSRDGLGRGSLFHAVKRTVTKSGSRLLRDRLTSPSASLPEINDRLDLVSAFFELEELTESLIFRLRRTFDVQRIVQKFALNKGDADDMLSLASAIAETVSTRDLLLSAFPGIDSDQPATNVQFMRRLLKRFDLEGPVELQASINSAIDEEGLQQKHRLEEDEAASVAAMAHEVVLQSAPEELESLPRAVRSKAKVEENKDDIVLEEPWIMRRNASDILSRLHQDLDDLQGEKAALAERLRSELSARTLVLKSTPGLGYICHIRSANGFNRDKLEALQARMVSSSKSTRSFYLTDWTRLGRRIDQAIANIRDEEKRIFTTLRAGVIHNLVKLRRNAAVMDELDVASAFATLAKEQSWTRPILNNSTSHKIVGGRHPTVKLGLEEQGRSFISNNLVLDQNEHIWLITGPNMGGKSTFLRQNALLIILAQCGSYVPATYAEIGLVDQIFSRIGAADDLFRDQSTFMVEMLETAAILKHATPRSFVIMDEVGRGTTPEDGTAVGYASLHHLYFVNRCRTLFATHFHELTDMTKSWDRLGCYCTDVLEDEDGKFTFVHRLKSGVNRQSHALKVARLAGMPESAIKVAEEVLKARIGKGYVRGHEDVFGADQGKEKDHNRKTEEITDSIRVAHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFC8</accession>
    <name>A0A0D2BFC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_11795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230235.1">
        <property type="nucleotide sequence ID" value="XM_016386103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFC8"/>
    <dbReference type="STRING" id="91928.A0A0D2BFC8"/>
    <dbReference type="GeneID" id="27338878"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11795"/>
    <dbReference type="HOGENOM" id="CLU_013753_0_0_1"/>
    <dbReference type="OrthoDB" id="2115177at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF5">
        <property type="entry name" value="DUF907 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G06100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239071" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="625"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="679"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW10019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="715" mass="78039" checksum="CC943D33FE1E79A5" modified="2015-04-29" version="1">MRTSSVAVFASLALLPSVIATDILKTSGVADCNNGTSQIKVNKLDISFDRSTNMINFDASGTSEQKQYVTAHLVVTAYGIQVYEKEFDPCSQDTRVDQLCPVPAGTFSANGSQEIPSSYTSLIPSIAYSLPDLDGDAQLTLKNKGGQQIACVQSGVTNGKSVEVPAVSYVAAAVAAAALGMSLVGAAATGAHPGSSTSSPGFSEVVWWFQGMAMNGMHSVPYPGIYRSFAKNFAFSTGLVSWGGLQRSIDSFRSHTGGNLTNENYDDLKNTTLVFSDGTTVQPTSTLGKRAMLFFRDVSTNVNGTDDSGSASGSDSTSQLVNGIQGYVEQLTIPETNTFMTVLLIFAIVVAAIVVGILLFKVILEAWALFGKFPKSLTTFRKEYWRVMAQTITSLILLLYGVWTLYCIFQFTHGDSWAAKLLAGLTLGGFTSLLAFYTWKIWSVVHKLKKMEGNADALYENKETWKKYKLFYENYKRGYWWLFIPCIVYMFAKGCVLAAGEGHGMFQTIGQLTIESLMLILLLWSRPYNRKSGNWINIVIQVVRVASVVCILVFVEELGIAQTTKTITGVVLIAVQSGLTVILALLIFINSIITCCKENPHRKQRKAAEKHIPQDIEGDAFMMVPTPYTSSPSRGTGKVSDPKQGYEPMRANAYSRFGPLRDDSQETLVKGAAGMGYSGYRSLSRGQDDADGSPPPPFSREPRLPDLSFEPFRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BG77</accession>
    <name>A0A0D2BG77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_04815</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237836.1">
        <property type="nucleotide sequence ID" value="XM_016379159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BG77"/>
    <dbReference type="STRING" id="91928.A0A0D2BG77"/>
    <dbReference type="GeneID" id="27331898"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04815"/>
    <dbReference type="HOGENOM" id="CLU_003818_3_0_1"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="651"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="694"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="421"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW17620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="748" mass="85032" checksum="A8CF55E5D0DD37A5" modified="2015-04-29" version="1">MSFQVPQNVPSFTNSQRAYEDTYWRQKQSNGHARVGSTGTVTSKINDIFGEHKDLPMYKDKPHFPSSRRKRVLQPKRVLALTALPALLFLWWMGWLPWTSGAVYDPAEHEHPFFKDEDWSAQRDAVREVFKTSWAGYEKYAWGMDEYNPLTRKGKNMVPGGMGWIIVDALDTAIMMNLTSEVAKAREWISTSLSYTANHDVSTFETTIRMLGGLLSAYYLSTSFPNLAPQRDDDTNQPGEDLYIEKAADLADRLLGAYESNSGVPYASVNLNTSQGILSHLDGGASSTAEAATLQLEMKYLAKVTGEPHYWQKAEKVMEIIDSHRREDGLLPIFIYPATGEFRGDNIRLGSRGDSYYEYLIKQYLQTGKVETVYRDMWDEALEGIKKHLITYSQHASLTILAERQNGLHSPLTAKMDHLVCFMPGTIALAVTEGETVEQAKARLGSRWTKKHDENLKLAEELMKTCWGMYKVTPTGLAPEISYFRTDNPPRQWQGHVDPDWTPPVSSDLSDAQSATWRSDYDIHTNDVHNLQRPETIESLFYMYRITKDPKYRQWGWEMFEAFREHTKVIDDVSGTVYAYTSLDTVMENPVKDRKRRDNMESFWLAETLKYFYLLFSDDSFFPLNSVVFNTEAHPFPKFDISGSKVFKTGWQRNIGAPPSPKPGSDGRVVRVDPAPQKQEERESNSGDAPEVAVPHEHEHDDTMEHGHIEESGRGKETGGHSPLENFRESPVQGRGQGGRMVESKGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGZ9</accession>
    <name>A0A0D2BGZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_11578</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230830.1">
        <property type="nucleotide sequence ID" value="XM_016385886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGZ9"/>
    <dbReference type="STRING" id="91928.A0A0D2BGZ9"/>
    <dbReference type="GeneID" id="27338661"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11578"/>
    <dbReference type="HOGENOM" id="CLU_002935_0_0_1"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="423"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="523"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="871"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="451"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="556"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="743"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW10614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1189" mass="132510" checksum="9E7639553975D079" modified="2015-04-29" version="1">MPPKKKATTHVHAAKPQPSKDSLENAPTPPSTLQKSDSVAHSATSINGQIPTTKGDNDSKTGDTTESAGEPNPTPAVNRKKQKRREKEAAKRAAEQKQPNGDAHPNPKPHGQLPPVKQGRGPVKGYFTEEPDYPDPSDPSYADIGSPEEAFYSGDEDPHFAEGADGMPDSSWLNTSKRKKSKGGKSHLPDTESLSRSSTMLSRSHIPPLSNAAMRASQKLSSSDHIWNTSTQAERENIKQFWLELGEEERRSLVKVEKEAVLRKMKEQQKHSCSCSVCGRKRTAIEEELEVLYDAYYEELEQFANHNTDLSSVPQMMAPPRPPFRRVTHPMAGSYPSRGRVHEVDEDDEDLEDEDEYDDEDDEAYSDEDDYDDHGLPPGPPDFFQFGNSLTVKDGILTVADDLLKNDGKHFIDMMEQLAERRMQREEEIHYPPSSYAHRDYHQGHNHPPIDDDDDYDDEEDDEDYDSQEEDDFEGDEMDSMTEEQRMEEGRRMFQIFAARMFEQRVLTAYREKVAAERQKKLLEELDEESRLDSQREAKKAREAAKKKEKKKLQKMAKDEERAKKEAEKAAQEAAARELEEKRQQDQRKRREEQRKKREAEKKAAEEERQRKEAEKHRKQQEQRERQLELERKQREAKERERLKREEMKKKEREERELKEKEARERKAKEDHERKAKDEQVKKEKEAAQKAEKDSRLHQPSTKQQPVVLPPGLHPPSRGSSIHSPHFQVATPVVPPKVPTPARNRQPSQPSQYSHGSSPKSQKASTDVSGSSISPATVAMPQTPAPGQHPKAQGQPPVLHHPQPSAPRSPLNNPGRGQYPFNMNGIPAAGVNGLAMGGQGMMPGMIPPVPNYQGPPMGNQQRFAMNGMQYPPGIPRPFQPGQQMPFVPQVPGQAPPMANQQTVPKPVGHSRQPSTDTSSQPTPISRPGPIARPSSTTPDKQKPIRGSPDADMEQLATQLGSKALLDDSDEPFLENSESRIGLAPVGPPSTRMPFAGSFSELKQEPFAPINHGWGGFHSGISPAATWGAPAPQRPNPGWSQPPFGALGGGPQPMPRSHFPRPIAVRLMLVQACRHLSQTPGSSADGYHPAQAVLRQLEMIKAPGEPHVSMEEMLGICDTEGNPQNGGGSFEVVMDKTRGQVIRFVEDAPVPNRGSVGEIGSPVMGHSQHIQTSPFGGIGTSSFGPPGRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BH77</accession>
    <name>A0A0D2BH77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238181.1">
        <property type="nucleotide sequence ID" value="XM_016379504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BH77"/>
    <dbReference type="GeneID" id="27332243"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05160"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="548" mass="61093" checksum="64864C82906AEC64" modified="2015-04-29" version="1">MAHHTDDNVVNVPTMAEEDTQHAIEVLHSQEKKINCSKRLVIYCFAMGFGSMSFGFGSAIIATTLGQPSFIEYMNLGPDNPDASHILGAINSLFYAGGFFGCIFASWSNDRLGRKPTIIIAAILMIISGALCAGSVKVGMFMVFRFFLMIWPIILTIITYSGLMFLITVPLWITEVAPPHGRGVLAEIHAWMAVLSYLIAAYTGIGFFYYRSTSHAEWRAPLAFVVLWPLLTLIFTPFLPESPRWLLMNGRSEEAFCIVQRLHRNESDIETEFVLAEFQIMRSQVEFDASLDSSWRILFTRPSYRRRLLLSASVLFILYSTGTQVITNYAPSIYAGLNFSAGTSLQFSGGQILVALLAISISMLFVEKVPRNWMLGGGTMATAIPLAIETVITAKYVGSTNTAGLAAGVAFIYMYTFVYTIFLDGPGYFYASELFPTHLRAKGSTVCMACYCLTNILWTQVAPTAFRNIQWRFYIVFIVNAIVFSICQILFYPNTLNKPLEEVAEMFGDHDLVGLYRGIQAERPSIDEKLHPTSDIGNPQESMVESTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHG6</accession>
    <name>A0A0D2BHG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231020.1">
        <property type="nucleotide sequence ID" value="XM_016384418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHG6"/>
    <dbReference type="STRING" id="91928.A0A0D2BHG6"/>
    <dbReference type="GeneID" id="27337186"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10103"/>
    <dbReference type="HOGENOM" id="CLU_000288_125_15_1"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15957" checksum="62C859F9BE18E8FC" modified="2015-04-29" version="1">MVEEQTLKKDHPHRLASQHELASAYLENGQVEEAAPLLEQVVTISKQTHGEDHPDRLTLEHLLSTIYWDLENRKAAIQMMQHVVEIRRQVLDEDHPDRKNSEDWLKHFESEIGRAEAERMSDTEEKKRDSKRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIP7</accession>
    <name>A0A0D2BIP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238661.1">
        <property type="nucleotide sequence ID" value="XM_016377091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIP7"/>
    <dbReference type="STRING" id="91928.A0A0D2BIP7"/>
    <dbReference type="GeneID" id="27329816"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02733"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_23_1"/>
    <dbReference type="OrthoDB" id="4120634at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF121">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="184"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="461"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="672"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="705"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="738"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="771"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="804"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="837"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="870"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="903"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="936"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="969"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="996" mass="111705" checksum="1D631B0002980FB0" modified="2015-04-29" version="1">MGFGFGVGDFIAVINLAGEIRSRFVDAPHQFRDLSNEVKSLSYILHDIEILPQPDLPGEEIAGFGEVIQSCKEVLKELEETLDKYQELDPTRRDFAGRSRRVWKRLRWDQKDIDRLRSRVTLNVSMLTTFLERISSQTLSAVKEGVNQLITHQRDQDRQAILNWLSPVDYALQQNDFIGRRQEGTGRWLLTSNEFRDWVSLSNQTLFCPGIPGAGKTISTAILIDELYKRFQNDSSIAIAYVYCNFRRQHEQKALDLLENLLKQLIWGLDVVPPSIQRLYEKHCLNRSRPSIDTISKTLQSIVPSYSRTFIVIDALDECQVRDREQAQFLTELLSLQTQAEINLFVTSRFIPGIEKRFRGSIRLEIRANDEDLSRYLHHHIQKLPSFVSRNSELQNNIKATIIKAVDGMFLLAQLHLDSLIGKRSPKAIRSALERLPKGSEAYDEAYCAAMKRIEGQISDSETLAKQVLSWITCAKRPLTTLELQHALAVEIDERELDTQNLPEIEDMVSVCAGLVTVDEQSSVIRLVHYTAQEFFIRTQRRWFENAETSIAEICMAYLSFDTFASGFCQSDEDFETRLKSNPLFDYAARNWGHHVRNSNDSHPNTEFLEDEAKVLASSQALMVMENHRYPGYSQRVPTQIRGMYLAAWFRLTEIVNWLVKKGHDINYKNSYGRTPLSNASANGSEEIVQLLLKKGAVVDSMDRDSQTPLLWASRNGHEAVVQMLLEKGAVVDSMDKYGQTPLLRASRNGHKAVVQILLKKGAVVDSMDKYDQTPLSWASGNGHEAVVQILLEKGAVVDSIGIDGWTPLSWASGNGHKAVVQLLLEKGAVVDSIGINGRTPLSWASENGHEAMVQILLEKGAVVDSIGIGDRTPLSWASENGHEAMVQILLEKGAVVDSTDKYSQTPLSWASGNGHKAVIQLLLEKGAVVDSIDIDGRTPLSWASENGHEAVVQLLLEKGAVVNSIDIDGRTPLSWASENGHEAVVQLLKKGAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJD6</accession>
    <name>A0A0D2BJD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231670.1">
        <property type="nucleotide sequence ID" value="XM_016385068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJD6"/>
    <dbReference type="STRING" id="91928.A0A0D2BJD6"/>
    <dbReference type="GeneID" id="27337837"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10754"/>
    <dbReference type="HOGENOM" id="CLU_112609_0_0_1"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
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    </dbReference>
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        <property type="entry name" value="HTH_3"/>
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    </dbReference>
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        <property type="entry name" value="MBF1"/>
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    </dbReference>
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        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
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    </dbReference>
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        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="89"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW11454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="157" mass="16891" checksum="DE32BDD3C188BE14" modified="2015-04-29" version="1">MADADWDSVTRIGSKARGPGAGGVDRERVVKGKSALNAAARSGAIIGTEKKFASSNTKSNVEGQHLTKVDREDDIVKPKYVSKEIGKLISQKRQEMTPKLSQSDLAKKIGEDAKTIQGFENGTAAPNQKVFDKLEKALNVKLRGTDIGAPKFAPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJG6</accession>
    <name>A0A0D2BJG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239249.1">
        <property type="nucleotide sequence ID" value="XM_016377679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJG6"/>
    <dbReference type="GeneID" id="27330406"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03323"/>
    <dbReference type="HOGENOM" id="CLU_850023_0_0_1"/>
    <dbReference type="OrthoDB" id="10421031at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="327" mass="36549" checksum="463301A9BBA49C15" modified="2015-04-29" version="1">MAATMTEEVTKKLEVRLLFNDTVTTESFLIPASEAPTLNDLYAAIHKRVDVGVHGLFNFFELDRPGLYVGSLYPALFLVQENSTNKHAVKHWRWTTLTWGHWMEYRRWYERNVQGSNPGDNLKVEMKLNMTRDKAFTREQEDAYVALTQKITDAGMGEDDLEWQAPPSMLKLDDVNNRKVWEWHPAHAQEGTINYVSIDAVPATDDWFPMRDPVSPLVTNGTCKACLKVAKELEIPKMGKKAIKKAKAKAKRDAAEAAAAAAAAAAEEAGVAGEGEEIDEDAMMDIVEEMEGEDGAEDEEEEEEAGGPDFSQPLALRPKDDDSMEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJG7</accession>
    <name>A0A0D2BJG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238966.1">
        <property type="nucleotide sequence ID" value="XM_016377396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJG7"/>
    <dbReference type="GeneID" id="27330122"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03039"/>
    <dbReference type="HOGENOM" id="CLU_562617_0_0_1"/>
    <dbReference type="OrthoDB" id="4150271at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239059" evidence="2">
        <location>
            <begin position="18"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="476" mass="51777" checksum="6464CB9685AF9F2B" modified="2015-04-29" version="1">MWSTVASWAALIAVAAALTRHYNPELFNKLTRRTTARSEPIETSQRPASKRQRTKRHQVGRLEPTDSGTATPSSGPEDKANKRRKVTSTPLETHASQRGAVEPATEEDNGMSNKEFARQLAKAQAGTKLEPAKAQGPSKKERRAARKASTTKQNGVHSIPTESTVENGDETDDDAVLETEPSSSSVSMDAPNEFGDVSDMLEAPTAKPTSLRLTNVKDAVAKNVTKPIAKAFEPVLSKKQRQRQAKKAEEKARMDESNRLQEAKKQNQLRTARMAEGSSNQTKANSFTARQNAWQQGKPSLSTEPSYKAPQAEAAPLLDTFNNSNEPATHVNGAVTSEPLSDLTNSVPETATVNTVRQDVGQSKTAALGASGREKVERPRLGTQSSWADEVNEEEQDKWATDLAAEEQWESVTSKKGKKKATEKSSSPARPAATVHNLTTTASKENGVQSRKENANRFQSFGQSAEASFKDADWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJI6</accession>
    <name>A0A0D2BJI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239274.1">
        <property type="nucleotide sequence ID" value="XM_016377704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJI6"/>
    <dbReference type="STRING" id="91928.A0A0D2BJI6"/>
    <dbReference type="GeneID" id="27330431"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03348"/>
    <dbReference type="HOGENOM" id="CLU_047025_0_0_1"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="497" mass="55848" checksum="8C6046CF5D951617" modified="2015-04-29" version="1">MIPGRRKFSRTRTGCWTCRQAGYKCDEVKPACGRCTRLKIACEGYAPRLVWRDTATPESGGRSRKRKQTSEEAPTSGLRYHFATPSTTSTGPAPQSIKSEDAVDVVPRELLSPHSSPASMAQGLRVEEYRHLHHWTTVVAPLLSVTSKAEVNPFQRHFIPMAYDNGSLRYTMLLCAAKHLSLLVNQPQDQQLILRYQGLALRNLNEALSDENEALSNPTLAAVLLMQLSQMFASDQESRADHLVGAKYIIAKRHRLANNPDSCGRFLESLFKYHDVMSSITRSDRPLLNHDCPPASDSDAFLGSIEPLLEIISQISELQPRKKLISQNSVEDTDEATSDSFIRISGSLLETQLESWNSPRKDADWFNTAEAFRHAAFIYLYRVIDDIGAPDPRTLYHVKQCVEALRSTAITSPLLSIHAWPIFTAGCEALEASERDFCRQRLDDMFNDRKLLSLLRVKRAMEDVWDQKDREALFGADVGKLDCINVLKQKGSNIDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJW1</accession>
    <name>A0A0D2BJW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239424.1">
        <property type="nucleotide sequence ID" value="XM_016377854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJW1"/>
    <dbReference type="STRING" id="91928.A0A0D2BJW1"/>
    <dbReference type="GeneID" id="27330585"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03502"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF39">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="46"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="566" mass="62585" checksum="BAEFEB59311C0896" modified="2015-04-29" version="1">MEKKVAGNDADVEEMAREESVRDASVHASELERRYGHVNRRLRARHIQFLALGGAIGTSLFLGIGSSLAKAGPLSLTLGFAISGMAVYGMASLSTRHYIHIRVNNVFQDGVSGRNVYLASCPGRDSSILRENWYFCAIVLCLDISAATLVIDYWPGARGVSPAVWITLCLIVILFLNIFAVSIFGEAEFCFASIKLILIIGLLILSVVLILGGGPNHDRLGFRYWKDPGVMNEVAPATGATGRFLGFFSVLIYAAFTYAGIEMIAATAGEAENPRRNVPKAVRRSIWRILAFYVLGSFCIGCIVASNDPHLLRAQAEGAPGAARSPWVIGITNSGIRVLPSIINVCILTSAVSSANAFLYTGSRYMYALAQNKQAPRVLLTCTKKGVPIYCVLVTALFGTLTYMTVSVAGNTVFLWFANLTTVAAMLTWISLCYAFIRFRKAQAVQGVSLDDPACRAYRPRFQPYIAWATLIYFVVLVVFNGFETFMRGNWNVNDFLVHYIGIPIFAFFILFWKFVKKTKFRKLEEVDLWSGKSEVDAMEGTWEEPVAKNWLQKVRSYSTRPTLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLG5</accession>
    <name>A0A0D2BLG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239631.1">
        <property type="nucleotide sequence ID" value="XM_016378061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLG5"/>
    <dbReference type="STRING" id="91928.A0A0D2BLG5"/>
    <dbReference type="GeneID" id="27330793"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03710"/>
    <dbReference type="HOGENOM" id="CLU_006237_0_0_1"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="920" mass="103197" checksum="AE26296CF075BD3B" modified="2015-04-29" version="1">MARPRKQYQSCDRCRQGRRACDAVANGANPLQRGAAQAVACSSCQKSKRKCTFNWLQQLPRGSLPERLKQKFSKDYDFVHHEQDLQPLRMPRLRPQPASPSGDMPMDATIQPASRHEDCHHAQNVGSTDLAIDSGSLPWTGDLLGTAAPTSNCAPQSFHWLVTSPPEIPTYVSGEEGFLLSKRLDEAGTVMTFDTWEPPSSSSSSSSSSSSSSPSSWRTHLPIFGYTLSTELFKGIEEYVTTTNAGPGHAAEIRSAPHGSFVADQSVYQPVHYSPTALSTPSREVQVSSQEFQLVQSYTKGLISRKLLQIYLESFENIPSLYFQGWNWRYRQDHTPLRGGFSFLQLAKNLDKMLDPLRRQPLSQQDSDKASNAFTYAIMAFASQWLQPDQTKSAEFTDQWAMHTAGIKLGEFQSPLQQELQREAEDALRSCLGLTSFQVILAQLLFSWFRKPRVADKNPFGTSPTHHKSTLPRSPGAHSPLDHTVLAVRQLLSWRRDIVATATEAADSIPRRGFVLPKSIPRQGYLAFSVMFRFGVMCDTTTAVMKDRLPVIPDQESVFEIEDVEPSGYSASEAVFSANRAVSMWDSLAPESVCKFGMTAPRWPWTDEVAARVLQEVLALKNLLWRRLPVIQTSTACASAPYDLEKHIGETCQIYQYVTKQYAEFLEDCRFHLAELSLKLKSWYLMICSHWHLACLILARHIELIDETGQSESVQRSLRQSSALVWGLRKDNTYAISRVASVAILPDFCSMSCAHEDKFFFFADQGALTTEPWSEVLYQSITRSCEILLFWIACIKEPSLNPDQLVWLRTNTNILDLIENASGCIEALKYLGGRSDHIMCTAISMDSRLQELKMDISHHTQPGGLGWRSGGQGATYDYSVLYDHLSYSDPCFDSDVPNSLSGEARLCYLQDIQSSTESFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM18</accession>
    <name>A0A0D2BM18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232450.1">
        <property type="nucleotide sequence ID" value="XM_016383827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM18"/>
    <dbReference type="STRING" id="91928.A0A0D2BM18"/>
    <dbReference type="GeneID" id="27336593"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09510"/>
    <dbReference type="HOGENOM" id="CLU_440069_0_0_1"/>
    <dbReference type="OrthoDB" id="4119174at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="655" mass="73547" checksum="342F72A9BC43A6A4" modified="2015-04-29" version="1">MEVPEMELPTIQEINQQLAKRRRKSYPKACYPCRCRKIRCDHMNPCGNCVKHEQPKLCVYLDQNGQARRQSSSAPSRASNASTKDRVAALADLERRMQTIAEEVVRRLGSSGPAQEQTQQLQRGGRSAGATSTPLEVPGYHRTSPRHTPPATVAVDELGPSVHVGTESLASILVETLRSGHPKTPAPRSGEGTGLSRDSAYETMKLLYMTDTGSTHPFTSLWKAGATVEDICLALPDDETFEQCLTSWQQSTNLISPSLPLVDFAADVRSFWVERSKGIKRESELRSTSWLALLFCILAGGCSYGEVHRSEMELNSRVFVCCAFELLRLDNYLLQPTLENVRVLAGLAAILRVQANPAASWSLLGMAIRAAQSIGIHCVPPPTEESSDTERQSWLLWQGLVWQDTTISLCYDRPPSAFVDGSVQRIPRPPSPKGYPYLESCYGLAMVMNDIYHDWTHSRRTGLRTLPAVRFQVAAEQILLWEASAEEYLRKRASCKDDQRRLLHDVFQIFVSFFVFQLHRHHLAAPTLFADGLQTASPSGTAEWESREGSEAQEQVCISRCETVLSRFMSLRKANYQASRLWIIMHICLGCGFYLAGQLKRNVEQEQVTSSEQGKRKAQLRLLRDLAQNFEHELPCTMHPQDMDVLNALRRIIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNW8</accession>
    <name>A0A0D2BNW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_01173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240814.1">
        <property type="nucleotide sequence ID" value="XM_016375538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNW8"/>
    <dbReference type="STRING" id="91928.A0A0D2BNW8"/>
    <dbReference type="GeneID" id="27328256"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01173"/>
    <dbReference type="HOGENOM" id="CLU_009001_1_0_1"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW20598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="851" mass="94261" checksum="C635D3A239D031BA" modified="2015-04-29" version="1">MATSIEVTQDIRRTRQCPYCQREFNKADHYHRHVRSHTKEKPFRCDTCKKSYPRHDTLLRHARTHQKTANRELTGKDNTDASISSASNRAASHPPAQYTFLPPYGPDSGPPELHTPRSRINQRSDQDSAPTGVVSVSQHQHGQGNVSAASFDDSVENQNFSNDRGIPTSQSLPSVSGTGTADGTHCSHLTSIYSHNTCTQGLVFTGAHDEQNSADWLLGHDFDLAAFGFPESDLVTDSNQTFDYDNDLGTALATQSKPGLRKLPRLLDFRSIWYTRIRTVDTGYRAGSGPGTITPVYGNSPSDTTIDEIYRVNMAGRLRVPSSDEPLPSIDFLNLCIHLFFTRFNVTLPMIHSPTFRPTRANALLVLSICSGGSISLGSAMANKAGSMLFERVNKAVLAATWDENFSHKPDHVRNVLKTSMIGQTFALLSGNPSHLLTAAAFHGSLISVARHNKLFQDTRTVELAEDLTPEELNDAWRGWARDEELKRIALVLFIHDAEVSALFHHEPLLRHNVRSLPTACSAELFSAPTAAIWATRYRAEQRDRLRQADQLSSGSFVTKTAESDASAGHLQTPVTVWPAQDHMLNVYTRISGISPSIIEARHMGCLTSPQAHKFESDLVSWYISVPTPFRELGTTSMQPEAPFTMLPLWHYSFIQLTADLDVLELAIGREGPLISDSTRSYALSWVASPDSKRCLLHALLLQNLMTSVNMGSFFPLHTARILFSAAVCWYCYMLYLPYAAATDQREWTFSVRSDHQPLESCPEVRLLREGDNPTSPAFTLEMGSCNDAISDLDRILNANTSEMKAGTLCVLEGVLRRLGTGGIARAFADIVQVFISGEVDKCNAQDTMHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP07</accession>
    <name>A0A0D2BP07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240859.1">
        <property type="nucleotide sequence ID" value="XM_016375583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP07"/>
    <dbReference type="STRING" id="91928.A0A0D2BP07"/>
    <dbReference type="GeneID" id="27328303"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01220"/>
    <dbReference type="HOGENOM" id="CLU_021214_1_0_1"/>
    <dbReference type="OrthoDB" id="5396420at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="74"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="456" mass="50555" checksum="BDBEA141874EC2EE" modified="2015-04-29" version="1">MSGESEYRPAHRSRWTYQAQVRTRSLDSIPPPTDSISLETAARQERAQKGPRRILVHLPPGPSLRTPAHDVQPQLRTLLSPNTSIVTVHYRLGLANDATTEETTCFPTPIHDVSTALEYLTSSTSPFNDGQHEAPRICLLGSHIGGALATMLALTQPNDVHALAAIEPLVDWVSLDEIVEQFRPIKDMARKRQKYKATRFGIEDGSILAAAEDLVKLRAKLFPTPSSYFDPFASPLLFLRAPGRDTPLSSTVGDELVEEMGLNEHDGGFVEFDYPEDPLQEEHSLYARSTNSPLSPRIGSTGSSEDPVTGSSSADTAPTSVATQPQSPPRRRKVLQRWPSIGRPESVLLPYVKVFVQSPPVSLDKVECMSDEIRSDLGHTALMRAQGKELVELMRRACFFGREKGFAEERVQLSEGIAHDEDRWRGDVESHPSTRRLSMHLQEQALGWAEAMLAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPM0</accession>
    <name>A0A0D2BPM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_01477</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241114.1">
        <property type="nucleotide sequence ID" value="XM_016375838.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BPM0"/>
    <dbReference type="GeneID" id="27328560"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01477"/>
    <dbReference type="HOGENOM" id="CLU_001485_20_2_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000021">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="16"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1506"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="611"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="743"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1467"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="434"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="758"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1468"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="118"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW20898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1644" mass="183325" checksum="D8AA851D0E1869C4" modified="2015-04-29" version="1">MAPTGGAAGGGGGGGNIKVVVRVRPFNTREIDRNAKCIVQMQDAQTVLQPPPEAEDRLRKGGKGGSEHQRTFKFDKSYWSFSKADPHYAGQDNLFNDLGVPLLDNAFQGYNNCIFAYGQTGSGKSYSMMGYGEDAGVIPRICREMFERINGVQSDPNLTCTVEVSYLEIYNERVRDLLNPATKGNLRVREHPSTGPYVEDLAKLAVRSFQEIENLMDEGNKARTVAATNMNETSSRSHAVFTLTLTQKRHDVETSMDTEKVAKISLVDLAGSERATSTGATGARLKEGAEINRSLSTLGRVIAALADLSSGKKGLKVPYRDSVLTWLLKDSLGGNSMTAMIAAISPADINFEETLSTLRYADSAKRIKNHAVINEDPNARMIRELKEELAKLRSQLGGGGIPGATEEVYPPDTPLDKQMVSIVQSDGSVKRVSKAEIMDQLSQSEKLYEDLNQTWEEKLQKTEEIHKEREAALEELGISIEKGNVGMSTPKKMPHLVNLSDDPLLAECLVYNLKPGITTVGNVDSSEASEIRLNGSKILEHHCKLENVDNVVTIIPNEGAAVMVNGVRVDKPRRLKSGNRIILGDFHIFRFNNPLEAKAERAERSLLRHSVTASQLNSPTPFRPSHERSYSATNSDFEGDSSRAQSPGFNNGASDWLLARREAAGALLGSDPKIMQLTNEELDNLFENIQRAREERRGRHESKLYEHDEDSDDLSSFLVRDKYMSNGTMDNFSLDTALTLPGTPSLHGGSQEDGDVTLTPSQFESSNEATTVPSAETKSDADVPQASKEPEQETQSRQMQKELERAKQEFQEELRKQKEAFEAQIKKMDLEVRTREAARRTSGFVPLDATEIAVARNVVEKWQQRNYILIAEAVLQNAGLLKEAQVMAKLLEQDCNFQFIILDLGEDRGSSYDLILHDISGDDDDALANARKPCLAVRVVDTQLSCVQLWSLEKLRLRLSKMRQMHQYKDQPEYLQHFRMDNPFRDSDQALFSLVGDGSIPLTAVFETRVQDFIVDVLSPSTRQIVGKVRMSLEPSLAESPPSTIKFNIIMRDLVGFSEHEGTQVHAQMTVLGTADESVATTQSIQGFGDGPVRFESIHNLSVRRSSEKSATLKIAIFAQVTSTHLDKLISWDELREMNESPPDHQPAPRLPESEYSVEERHDVFAKVQMLELAENGQYMPVEVLQTSADDNGAFQLHQGLQRRISITLTHSFTESLPWDDLNGLRIGEVHLIDSSGRIADITSVTPDIALKQIQEPMIKDNADGTSNITVVGQWDSSLHKSLLLDRVTNEHCRVQVALRWNVASSRLEQPMTFSIDQQLQILPRSYVRPQSMFKTFWNQTRITHSTDGLFSIVVRPISARRAADLWRLDTSKNYVKGEELLGHWSPRGISLVKDYIVARRKRRQLQDIETARAALGLKRLSINKIRSRAASPSNTDPREEALLRKYLAIWMKPSVEMSNPIFDTEHSISTPAGNSTPLSEAGNTASSSRKTRYLATVTNNPKNPVSLKSGYLLMPSENLDPSHAQSMQWKRRFVDLRPPYLHIHSVPDGEGINAINLVHARIDHDPDFKRLLGSGSISSGDADYAERGHRRAGSSELHGLAHVFAVYGEQNTFLFAARNESQKDDWILKIDQSYFGTEEDERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPN5</accession>
    <name>A0A0D2BPN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233265.1">
        <property type="nucleotide sequence ID" value="XM_016382562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPN5"/>
    <dbReference type="STRING" id="91928.A0A0D2BPN5"/>
    <dbReference type="GeneID" id="27335319"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08236"/>
    <dbReference type="HOGENOM" id="CLU_011608_3_0_1"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="150"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="322"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="507"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="649"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW13049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="739" mass="83005" checksum="5EEA76538D7A5FF1" modified="2015-04-29" version="1">MASSTKRRKLSDDNYETVPSSAEKPVVQDGAPPKEQRNSLFVRSLPASVTTERLAEHFSQSFPLKHAIVVVDPETKISKGFGFVTFADAEDAQAAIEQFNNTTLDGRKIKVEAALSRHRETEEGLKTSQNRTAAELRAQREKEKTQEQPPRLIVRNLPWSIKTGDDLAVLFRSYGKVKHAVVPQKGPRVQYGFGIVVLRGKKNAERAIAGVNGKEVDGRTLAVDWAVDKETWEKQQKHQHDNSKSPSQTVDADAAAEAASDIAEDSYINEHIDDDDDDDDAVPEDDSDDEVVDDIDRVDLEEDDSEVDASEDEEQHDRRNDSTVFIRNLPFTADDDSLKEHFSSFGPVRYARVVYDQETERSRGTAFVCFYKVDDAKACVKDAPKPPSVTAANDNEKKRKGEAMKHSILQNEATDPSGRYTLEGRVLQVSRALSRGDADRRAAEASEKRDIRDRDKRRLYLLSEGSIPRGSKLYELLGKTEIDIRESSARQRQSIIKNNPNLCLSLTRLSVRNLPRHVDSKQLKALAREAVVGFAKDVKAGLRQPLSKEEIRREGQEMKEAERQRRFAGKGIVKQAKVVFEDQKGSKVQDGAGRSRGYGFIEYASHRNALAGLRWLNGHMVKSADGERGKRLIVEFAIENAQVIQRRNEKERRFKENRGKKAHSENAGDDKKQRDGPAKAGKGSKKRKHREGEAEGGGESEKKEKKNIGDAVKEDEKNSIAKRNRIIAKKRQARKNRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQU0</accession>
    <name>A0A0D2BQU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241589.1">
        <property type="nucleotide sequence ID" value="XM_016376313.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BQU0"/>
    <dbReference type="GeneID" id="27329036"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01953"/>
    <dbReference type="HOGENOM" id="CLU_001204_3_1_1"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="642"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1528"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1588"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1545"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1560"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1602"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1620"/>
            <end position="1644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1644" mass="182062" checksum="FD2E1C1C6E6B9439" modified="2015-04-29" version="1">MAIPRPDVSIPEYDTLSMHPLAPGHTPVIHDVTPAIAIDPVALITTECITITSAMRKHARWAQSSVATILGGGASRLQESELRRSPSQSRRGTPVITDPGKTKPNANNLSDDENASLASRWGLRGKKGKSLQDNPLLTAFSRLRRDLAGCKDVRTVDAPELLHPFLQVIRSSSTSAAITSLAVISITKFFAYNIITIESPRIGPAMHLLSAAITHCRFEASDTAADEVVLLRILRLMENIISRPEGQLLGDESICEMMSTGLSMCCQARLSEVLRRSAEMAMVTMCQVVFSRLKYIKVEELPKSRSRSGTKTALINASEDLKIEPPMTGSVMGNGESVRPSVDADPRPSSEPASEVTASKSEAQNTAAPVNEKDDEKVEPYSLPSIKELFRVLIDLLDPHDRTHTDPMRIMALRIIDVALEVSGPWIAKQPALAALVQDDLCRHLFQLVRSDNMVLLNSSLRVAGTLLATCRQLLKLQQELFLSYLVACLHPRVDIPQEPGIDPALYEGVPQAPKLVKQAPSQSSSGRSTPVPIKDRQKLGLEGGARRPEAREAMVEAIGTLVRMPSFMVELFVNYDCDVDRQDLCEDMVGLLARNAFPDSATWSTTNVPPLCLDSLLSFVQFMADRLHQEIPTDAQQRIEKMQLQRARKKIIKSGASKFNDDPKAGIAYLVRNGIIKNPDDPLQVAQFLRGTSHVSKKVLGEFLTKKTNERLLTAFIGLLNFENKRIDEALREMLGAFRLPGESALIERIINIFTDRYCATVNPEEIEDKDAAFVLTYAILMLNTELYNPNVKPQNRMGFEGFSRNLRGVNSGKDFTPEFLQDIYDAIKDNEIILPDEHDNKHAFEYAWKELLMKTSDAGTLELCRTNTFDAEMFKATWKPIIATLCYVFMSASDDAVFSRIVVGFDQCAQIAAKYGVTEAFDRIIYSISQISGLASEIPPSTSLNTEVQVGKRSIMVSEMAVRLGRDFKAQLSTVLLFRILSGHEDAVGETWIYVVRILRNLFVNSLITLPNVESTKFAGIDSIPLQPPSHVVDRDGNLAESGLFSTFTSYLSSYAADDPPEPSEEELENALSSVDCVRACQPDKILNHMASLPPNQIQSLVTALLSQMEDSSPVVTVKPERPLPVTQRVNGHRLPKAGPEYDPGTIFLLELATILTLRDEETTAAAGEALTGSLQNAVRDASNIHPLALSRIVHYLLEVLRHGYTFDFIRAPVVLHAISSFDDAVLDRTAAAITRDLASCIAVPGALTNEITTSPDFWSTLQRLHQHRTEAEKVFAILTTLATSMPATVTADNFESVIGLANDFAAAGSIGSIQEKRRDFAAKRGHQANPAREEDGAVVQRANKAINLIYQLNDRVPDLIAQSHLDRNEAWAAYWSPIFRALCTQCVNPCREIRHRAFSALQRTLLSDTVADKEQHHEWIAMFDEVLFPLTLRLLKPEIYQIDPPGMNDTRAYAASVLCKIFLRYLDRLVEVGRMGDVWIKVLELLDRLMNAGTEGDALAEAVLEGVKNVLLVMDGTGYLGRDNAVVQPGVVPSPRAQTPAESEDNNDDEDEEKVGEEDHKQQERKLDDSRIWPETVRRLDRFLPGLVQELFPPAPVETEPEEAEGTVDEEKGSADEERETVDEEKETVDDEKETVGPEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRA1</accession>
    <name>A0A0D2BRA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241171.1">
        <property type="nucleotide sequence ID" value="XM_016375895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRA1"/>
    <dbReference type="STRING" id="91928.A0A0D2BRA1"/>
    <dbReference type="GeneID" id="27328617"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01534"/>
    <dbReference type="HOGENOM" id="CLU_006057_0_0_1"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1028" mass="112033" checksum="2AA3EE92DACC5945" modified="2015-04-29" version="1">MVSVESTLTHTAVSGIASVSAELTSAGLETAAANATSFFGSASSKDFLRAPLQIASQLEQSFLGLWNTFKVESLGRHIFFGPGTVRQAADTGAQVMADAAANAGAAQAMGEAGGAGWAAFFAEAFQASTFKSYWGMLHYITSRWAFTCFAMALILNRIGVYGASRQRIYLDWPKRLALRIVPILLFISQIHQLLQAIRCQTSPDFSLYRHGDNNKYSLLDWSKDGGALHTLSSAILFGSTDASACAAVGLSRPSPDVRAPRGSFSLLWPSFLRLSLSHIVESLSCSLQQIPAMTEVGMTVFEHSLAFAEAETALAHTLGLGLFGSSKSSDASSSNITMSSSEPTIPASGTILALADATASLTGPHILDRVNVPVEVLLVTLLSCGNSLTSHVLAVMGKQRRWRLVNTGIWGMAFMGSFVWGLFSTSTMVRGGDDGDDRPVSSLLHFPTVAIVGFLPHMAILLGIGVCFIIYLVALTFTAISLGTNPHIPQPSSLKERFSIAHDNLQAAIQTRGINIRWYEDFYTALLRVGFAALTAASESVFLNEGRAVEVRQFTWIEEDRLDEFEGAGDEKLGTTRGQQFQILEEYGLPSSTPGGTDKGGVWESGYSKERKFDKKDGELEGKDSFVYPTPQNGGVGAVQRTTRFYLLMIYLRGIIFLIAGYVGFGAGVLLDSIGITGRPSWLRKLVGRSLKKMHAERNSNGRGRMLDFWLIGEDGKLTVPLTDEIDIEPEMRRRLMTEFPSDKVDELLDSKLYDWWRSGGWFGVKDGSGDYQPPPQHDGFDDTTSVISMSTEATTDRSESGVDEDEDGWESEPDGTKTPTQASAGPTWSFAGIESRESSPFTDTPLDATSLARLLDPQDRESRDEARILAAHLKSVSAESPGIMTRSRYRREMERERARILLAGRTPPKLPSHVPTISLFDTSHVSGPRPLTNAEEAEVLESLILSRRKRKPTASQSHGRFDSAEDESSQAGPCCVVCQTSPRSIIAWPCRCLIVCEDCRISLALNNFGNCVTCRRPVQGFVRLYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSV9</accession>
    <name>A0A0D2BSV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241711.1">
        <property type="nucleotide sequence ID" value="XM_016376435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSV9"/>
    <dbReference type="STRING" id="91928.A0A0D2BSV9"/>
    <dbReference type="GeneID" id="27329158"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02075"/>
    <dbReference type="HOGENOM" id="CLU_357532_0_0_1"/>
    <dbReference type="OrthoDB" id="5404794at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="786" mass="85885" checksum="69477BDF38E1FAB1" modified="2015-04-29" version="1">MPAEIADSDAESDFNSPVKKTVAMEEVAGFGDGARPSQVSLSGYDFDQFLDPTQRLSSLSPGHANGAPTASELLAGLPSESSPMQMGRGSDASLVYGKKRAHSDYQDPSETLFNEPSLKSASSKRTKTYAHSSKPRGILHDIDLFAPSAEPYSGEIHRSESDQKTSALNVDLSIKTGPPNGAVNLLGESLTGSTHRLSTSVASMGQYESINLDFRGSGQGMDINANPFGSLSQISSRELQLPDHTGSADGLSTSAEYQPEEYNQRNLEVLKNLDLPHQHLSTMELSSPRPLLPINPYRIMQNDGPTAEVTEEIVQAADKCTDAPITMAEPASNATVIEKPPPKKRGRKPKNSQVSSNTPFPAVDDDMDELAMHELATVNRSRQGTVDSVYSQASQASTGKTSTRKRKRQLSTQVGDAREQSRQSTEPSPVKEPSSEMILGDEALIGLPKEQYKPRPSRSRSKRVADVENTDSLCLEQQTPANSKMVDFEDPKEQTPVAASTKPSAKKGRKSKVKRAKTSAAALLKRGEPMLSEGEDDVVWMDTKPAPVKLDLPPDLKVLKKEDDVTEDIETAKDPQKVQLQEIVQGGKVSVEIRTDAPAEDQEPVVVPKKRGRKPKKTPAVSETKTIEEQDEQVDKKRKALAEKSGNMSSDHQDQAKDDDPKVPTVSPLSSPEPEEQQKPLEQTPKVAVVLNPPPKSTPDKPPSTHSPIKSTLLSAGKKTIYRIGLSRRQNIPSLLRKVQRDKPPPKIVVRKEKENKKKKNDCSDDENTDRNEMRGADGMLVEWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BT58</accession>
    <name>A0A0D2BT58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH-response regulator protein palH/RIM21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241806.1">
        <property type="nucleotide sequence ID" value="XM_016376530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BT58"/>
    <dbReference type="STRING" id="91928.A0A0D2BT58"/>
    <dbReference type="GeneID" id="27329253"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02170"/>
    <dbReference type="HOGENOM" id="CLU_014594_1_0_1"/>
    <dbReference type="OrthoDB" id="5393256at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="697"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="783"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="92096" checksum="56E3CDEE3BB6CCAD" modified="2015-04-29" version="1">MSHDAHITARQLWGQLSTVAPTATSAWCTPLILPSGGVLVFGNDTTTTLSAQVTFKQPCDNPNQIISPDTTGNSSVIGFQNPFYASISPQVFALATATVIGYVLVILIFITPRTFYVGGPGGGAGFLGGRGAIRGSYGSSPIVGVGRRPLLQKIATVTVAISLTIATADTFRVAEEQYNKGYMDSSQLVDDVVDSLEIRIVRIISDTFLWLAQVQTLIRLFPRHKEKVAIKWLGFVMVSLDTIFSILDSFVSGNGNPRTRPRKFQDAIPALNYLFELAISLIYASCVFYFCLSKRRFAFWHPKMKNICLVAVLSLVSVVIPVVFFVLDVAQPNLAGWGEYIRWVGAAAASVVVWEWVERIESLERDERKDGILGREIFDGDEMLNMTPSEDANWRGQDGNNDSDGPHHKGMAETFGSRYRRIRSRLPLRKRRKGAPRDGITTGSDALDSSHRMTNNGQVMRPEQVVAPPSRSDTGSAASTVYAIRYHNLTSPSPNYQQNLHQALRTVAEPAVARVNTRQSDSDSVRNSADKEIVLESAVRKDEANARHIWQTMPNPFKRRRAEPPAEVADAQISSGIRRSPIDRHINLRSRLEAFAAAQRDRFGNRGNASVVPLPVTVIPAPKNNDRTWSPDDIVDEETPDDGAVHMANLGTSDLQHPQFQQSSRHQDVQHMVVIPAPSPGRTWSPDEMNATPTIVEGRTPGRVIGGTPTSSPASNVVRTQRGSLTISESERYANRLPPSAEPASPRSPVRIPTAAIQSIAENSPAEGETVAAIWLAPLREDRQREENPTGAAGALTMPQGQGSQDSEGLTPSFDNGVSTPRHDSGPRAEDGRNTGGTDSHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVE0</accession>
    <name>A0A0D2BVE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235455.1">
        <property type="nucleotide sequence ID" value="XM_016379628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVE0"/>
    <dbReference type="STRING" id="91928.A0A0D2BVE0"/>
    <dbReference type="GeneID" id="27332367"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05284"/>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="489" mass="53313" checksum="D825CC078579989C" modified="2015-04-29" version="1">MANGTSIKRTPVPAPLEDDESPALLHRSLRLRPYNVSSAKGIYITLKDGRRVMDGSAGAAVACIGRGNDEVAAAVAAQLQTGVSYLNSVAFTTDAAEELAHFLIDGPHGGGRFGFERAYFVSSGSEANDAALKLARQYFFEKDGAETLRTRYVARRQAFHGTTVGGMNVSSFVARKVPFANFQLQNVSWVTPAYQYQYSNWQQGETEDEFAARLVVELDEHFQSLGPETVIAFIAEPLVGATSGCTPAPRGYFKGVREVCDKYGIVLILDEVMCGMGRTGTLFAFEQESIVPDIITIGKGLGGGYLPVAGVLVHKKIIDVLRKGTSSFNHGHTYQAHPVGCAATIAVQKIVRREKFVENVARLGKWLHPLLLETFSSLKYVGNIRGRGLFWGIEFVQNKATREPFPSSLGFGLRYQATCFELGLAVYPGTGTVDGKMGDHCILSPPYNVTEEELRKMVQIMKQAYGQLERQVDGEMTQKQGGNGVVETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWD7</accession>
    <name>A0A0D2BWD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_05607</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235775.1">
        <property type="nucleotide sequence ID" value="XM_016379948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWD7"/>
    <dbReference type="STRING" id="91928.A0A0D2BWD7"/>
    <dbReference type="GeneID" id="27332690"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05607"/>
    <dbReference type="HOGENOM" id="CLU_049363_1_0_1"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW15559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="295" mass="31169" checksum="B4A0F1796CF2B61A" modified="2015-04-29" version="1">MDPFSGEGELLNITTAFYTHAYQTVLDFDTSALSPANQAVAQTLKYRAQIALGDSSSVISELKPKASSSPSSRALLALAQNDVEAATELATDASTAEDPVVQVCAGTVLASAGEYATAIDLLSKHQGSLEAVGLLVQIRLSQNRTDLAVKEVQGAKRWANDSLLINLAESWTNLRAGGSEKYQSAFYVYEELASAPGNTSPTALLCQAIAELHLGRLEEAEVALQQAVSSDGADVQAIANSIVLASVMGKKDDVVKGLIEQLRERDQGHVLLKDLEEKSALFDAAAAKYSAKVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWU5</accession>
    <name>A0A0D2BWU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsuA/THI5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_05829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235995.1">
        <property type="nucleotide sequence ID" value="XM_016380168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWU5"/>
    <dbReference type="GeneID" id="27332912"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05829"/>
    <dbReference type="HOGENOM" id="CLU_072759_0_0_1"/>
    <dbReference type="OrthoDB" id="2093528at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW15779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35322" checksum="335D7CA4EA16DE3B" modified="2015-04-29" version="1">MDALAQGRVKPAGIDLNYITIEHPRDIFDRMIRGMEFDASEMSVSEYICRWADGERDLIGIPILPARAFRHNCIAVNTDIIQKPSDLNGKRIGVQLYTMTAAVWIRGALQTAGVDLSSITWVEGDIKKPGAHGKPKAKPLLRPVRIVPYMDAARSLSDLLADGDIAATIGADTPPCLGKAPNVQRLFPNIRETEKRYYQDTGIFPIMHLVVIKKDLVDKHPFVPSSLFHAMNESKDIALRGMRFLATYRYMLPFLPADLEEIDQLFGGDPWPYGIEPNRKSLEALVTYLYDQAMVDRKIPLQELFGPVHGPNLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXU8</accession>
    <name>A0A0D2BXU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carbonic anhydrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236315.1">
        <property type="nucleotide sequence ID" value="XM_016380488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BXU8"/>
    <dbReference type="STRING" id="91928.A0A0D2BXU8"/>
    <dbReference type="GeneID" id="27333233"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06150"/>
    <dbReference type="HOGENOM" id="CLU_084253_4_0_1"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19313" checksum="C08D06D7FB17FB2B" modified="2015-04-29" version="1">MATVRSKIERLLEKNVEYSRTYPGTFTLKQLQAAPGPKVMLLTCLDPRCVPENFFGPGLFASSFRNAGGRVTEDAIRSITGLRALVGMKGVAVVHHTDCGVSHITAEEVREFIKPGGPGAAVEVENIDYQFFTEEGFEEALKEDVRKLRALKSLAGMEIYGFAMDTQTGLVREVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0J0</accession>
    <name>A0A0D2C0J0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237380.1">
        <property type="nucleotide sequence ID" value="XM_016378703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0J0"/>
    <dbReference type="STRING" id="91928.A0A0D2C0J0"/>
    <dbReference type="GeneID" id="27331438"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04355"/>
    <dbReference type="HOGENOM" id="CLU_019028_0_0_1"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000043">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000009">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014485">
        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF43">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY (AFU_ORTHOLOGUE AFUA_3G04160)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017316">
        <property type="entry name" value="Pesterase_C1039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239371" evidence="1">
        <location>
            <begin position="19"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="3">
        <location>
            <begin position="360"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="602" mass="67919" checksum="6E6F84FC31C1CD76" modified="2015-04-29" version="1">MALKTCLALLLLALQACAVQPGAPEALAAPLRDLEFGQINFLHTTDTHGWHAGHLLEPSFSADWGDYVDFAGRLREKLEAEGKDLLIVDTGDRIEGNGLYDASEPKGLFTFDIFRKQHMDVLCSGNHELYKQNSSENEYLITAPAYPGSYLASNLDIHDPDTGEVVPLAPRYKKFTTKKQGVRIMAFGFLFNFDRNYNNTIVQRVEKAIQEPWFQDAICDREIDLFVVVGHSAIRSEEFDLIFRAIRSVQLDTPIQFFGGHFHIRDYRIFDTKAHALASGRFMETIGFQSISGLSTNTSQGTSPTFFRRYIDNNLYSLYHHSGHNSSTFHSDRGRNITEAIHQARQALDLDQTFGCSSLDLWMSRAPYPSNNSIFSWLEEQVFPEVVNDPQRNDRARLIISNTGAIRFDIFKGAFTKDSTLIVCPFTSGFHYLKDVPYKRAKKLIYLLNRAGQIFENADPTLAMSKLAPVDQMGILQDVVVEESLPSHQDMQQFSLAANDALTPGYTTVDDAGTDGDDTVHTPISFYRVPNCIQSTVGLPEDNQEEATVDVVFNEFVQPWILLGLKFLGLDYTDDDVDKYMPDENMTTLIAKWVSENWAENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C1J4</accession>
    <name>A0A0D2C1J4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">sterol 14alpha-demethylase</fullName>
            <ecNumber evidence="10">1.14.14.154</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">PV08_04718</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>32-hydroxyeburicol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxoeburicol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75431"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:194328"/>
            <dbReference type="ChEBI" id="CHEBI:194329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:75432"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>32-hydroxylanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75107"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:75108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>32-oxoeburicol + reduced [NADPH--hemoprotein reductase] + O2 = 14-demethyleburicol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75435"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:194329"/>
            <dbReference type="ChEBI" id="CHEBI:194330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:75436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>32-oxolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75111"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:75112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 14alpha-formyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a Delta(14) steroid + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:68068"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:68069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 14alpha-hydroxymethyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-formyl steroid + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68064"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:68065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 14alpha-methyl steroid + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = a Delta(14) steroid + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54028"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:54029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 14alpha-methyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-hydroxymethyl steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:68061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>eburicol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 14-demethyleburicol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75439"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:70315"/>
            <dbReference type="ChEBI" id="CHEBI:194330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:75440"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>eburicol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxyeburicol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75427"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:70315"/>
            <dbReference type="ChEBI" id="CHEBI:194328"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:75428"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:25286"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:25287"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>lanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxylanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75103"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:75104"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 23">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 24">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="10"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237740.1">
        <property type="nucleotide sequence ID" value="XM_016379063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C1J4"/>
    <dbReference type="STRING" id="91928.A0A0D2C1J4"/>
    <dbReference type="GeneID" id="27331801"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04718"/>
    <dbReference type="HOGENOM" id="CLU_001570_15_0_1"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 23 24" id="KW-0349">Heme</keyword>
    <keyword evidence="7 23 24" id="KW-0408">Iron</keyword>
    <keyword evidence="9 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 23 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 24" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 24" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="23">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KIW17524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="530" mass="59736" checksum="D198AD0E50B177FF" modified="2015-04-29" version="1">MGLLATVAAPLDRLLQNLPVYQTVVLGFVAFLLLSVVLNVTRQLLFKDKNAPPEVFSWFPLIGSTIWYGMDPFDFFFSCKEKYGDVFTFVLLGRKVTVCLGTKGNEFILNGKLKDVNAEEIYTGLTTPVFGEGVVYDCENAKLMEQKKMVKFGLTMDAFKSYVDLISSETRLFVENNKLFKGASGAIDIVPAMAELTIYTASRSLQGKEVRAKFDSTFADLYHDLDMGFAPINFMLPWAPLPHNRKRDIAQRKMAETYMEIIRERRAQGGKRAGDEEDMIWNLMNCVYKDGTPVPDKEVAHMMIALLMAGQHSSSSTSAWILLRLATRPDIQEELLEEQRRVLGKDLPPLTYDGLQKLTFNSKVVKETLRLHAPIHSILRKVKSPLTIVADTPTATKTYMIPTTHALLSAPGVTSRESSYFPEPLLWEPHRWDEGHPLAYTQMGMEKEEFEDYGYGMISKGASSPYLPFGAGRHRCIGEQFAYVQLGTVLATMVRHVKFRQPEGKSLVPTDYSSLFSRPMGPAVVEFEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3J9</accession>
    <name>A0A0D2C3J9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238430.1">
        <property type="nucleotide sequence ID" value="XM_016376860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3J9"/>
    <dbReference type="GeneID" id="27329585"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02502"/>
    <dbReference type="HOGENOM" id="CLU_015590_3_0_1"/>
    <dbReference type="OrthoDB" id="2578740at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="353"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="618" mass="69270" checksum="B67A7943B1DA6453" modified="2015-04-29" version="1">MIATTTTSTTPGPLPPLASFKSELRVKKLFDDVVIRDIDRAPESKTFNYQGFQPGSQVLKAGFKKAPDRRQFGVDTIFDRDVEIVVRDGARIFTDIFRPITSEAEPVPALIPWSPYGKSGTGAQDYDNMAPFRVGIPKERTSGYEKFEAPDPAEWSERGYAVINVDARGAGHSDGIITYFGDQEAEDIYDTIEWLITQKWCNGSVVMAGNSWLSLSQINFASRMKHSALKALAPWESFNDFYRHAFNRGGRPHLRKFHAMISGGMAGPEGAEDVFAMTAHRPLYDDYWEEKRIAIENIDGVPVYALASYSSILHTYGSFALFRDSKTKQKWLRVHPYQEWYDIYRDDINDDLQKYFDRYAKDIKNGWEDSTPSVRLSLLGFESGGGIAKTIVERPEASWPLEREELRTFFLDASSGTLVPDHLSASSSITYEAHHLTDSADFTLYFNQQTELAGYSKATVWVSTPDHDDMDVAVQIRKINAQGKPLKHLNYPCPVPESEVPDVNTAKTLGPQGFLRASHRGTLDRSKSSSDVDLFYTHRFSEKINPGTKVRLEIPLWPIGMVFAPGEGIMLRVSGHDMSLPEIPSCTLTEPDDDNVGNTTLYTGGEFDSSLTLPFILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C5Z3</accession>
    <name>A0A0D2C5Z3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_03248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239175.1">
        <property type="nucleotide sequence ID" value="XM_016377605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C5Z3"/>
    <dbReference type="STRING" id="91928.A0A0D2C5Z3"/>
    <dbReference type="GeneID" id="27330331"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03248"/>
    <dbReference type="HOGENOM" id="CLU_069176_0_0_1"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898:SF13">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="40"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="YEATS" evidence="9">
        <location>
            <begin position="138"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="290" mass="33114" checksum="AE9C71909A4A5016" modified="2015-04-29" version="1">MKRTHGMTELTDSAADPKRPETSPSAGDTLTDAVAGDDLCPICLQLLYRPVRTACNHTTCEDCMANWADVCVSSQMARDGIVDQDLVFLPEEVNTSCPMCRTTTTTIFDNDRQLTLQRLYPKIYVAREADDIAAERMRAASNIETLLIHIGNEHRLVRAYDESKNTHDWKFFLRPSRTDIIQEVQIILHPTFHRPRVVLSCPPYEIRRLGWGQFAIVANVVLKEGYSWVGARRIDRLDEGWERKLILAWNLDFSERGAHGRIRVKVRKERTGDEAEGDAPMEDEGHHQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6U7</accession>
    <name>A0A0D2C6U7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03598</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239520.1">
        <property type="nucleotide sequence ID" value="XM_016377950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6U7"/>
    <dbReference type="STRING" id="91928.A0A0D2C6U7"/>
    <dbReference type="GeneID" id="27330681"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03598"/>
    <dbReference type="HOGENOM" id="CLU_006173_1_1_1"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF4">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="806" mass="91488" checksum="C06C413562CCF283" modified="2015-04-29" version="1">MDTPPSKRKSSFGSDGPVLFSKRIKPLREEPAHYSDAVRKKLTSTSRTGQACDRCKERKMKCDTDPIACGPCRQKLLRCYTTDRVTKQARERGETDRAENELLFLRDQLAAYQLKYGPLQSSDLNVSLTETPTLKEKIPVHSSASLPDAHYVGWPAPDHCEPMRSGPVQGTVVDVLDGQIDIADWECEMMKDYPKDTMNRFNLSATSIINTICGYQRIEDPRPPPKEQALRDANHFLVIMAQYVPIVHQSSFMDLVHRFFDVPEFLTPAERVQVYMLFAIITHQTAVRNHLHSADRFEESHRYFHVALGHDRDLFHDRSLASMQALAMICVHLRNLPKPGISWVYCHKILVRAIELEYHRDPDKIRLPEAERDPLSKQLRIRVFHVILGICVTTGCRVGLPAPWHFQHMDVPLPRAIKDSEISRHGVAAQLSGLCDFWPCLHLAKLLPLLTELHNNIVAVRKPAAEYLQTVEALNTKILAWRQDWEDTIKFEAKQVNLHVAGLLIETWAAEYQLNLFHPVCCTSDDPEVHERHLDICHKAARRLLQAFHTLSSRYKGVDFTWHSTLAYATGFGITLFVYRRKTTPVTSEQFEAMRNELKGWISLMAYADLVLRTGNHLQRQFQPRVQSLEDQYRQLVFDDKASVTPLPFNAVNGSYGPQFKHPKPESETLFSYLDPHATPVQQKNSLPQPQFTQNQIPAGVPQQWPSPFSILPQPIAPSQISPPLFSTFSQSSNAALTTAPLQTVPTSLASLLNDSSSMYVSYPTPPQSQNGLNGDSYMSFQPSHYFDGPGPLTWPLISMPPTTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C972</accession>
    <name>A0A0D2C972_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240330.1">
        <property type="nucleotide sequence ID" value="XM_016375054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C972"/>
    <dbReference type="STRING" id="91928.A0A0D2C972"/>
    <dbReference type="GeneID" id="27327772"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00689"/>
    <dbReference type="HOGENOM" id="CLU_036005_0_0_1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="91"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="361" mass="40335" checksum="7B3D6C09C29E95CA" modified="2015-04-29" version="1">MIAKTPVEILDPEVAALAAKYDVYEVHKALAARDVANAYPLAKYPEYLPSTEHGSNPGYHGEFDHIEPGTRADPAMPNLKGLPGYTEDCIRYITPRLGSIIKGVQLSKLTAAGLDELALLATQRGVLAFHDQDLKDQGIEKFKEFGNHFGPLHRHPTQSLVMAPRTRRLRSVTSHERKEAHSLTECRYVQWHTDQCHEPQPPAVSMLVALEVPATGGGDTLFCSATRAYDTLSPAMQKFVCTLWSENSSKLISDSSAKIGGPVRRAPVPIAHPVVRVHPTTGQRSLFHNPHFSTDRIHNLKEQENIAIGNFLRNHIENSQDFQCRVRWAEGAVVVYDQRVVFHSATHDYEPGDRRHLLRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAI0</accession>
    <name>A0A0D2CAI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_01149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240790.1">
        <property type="nucleotide sequence ID" value="XM_016375514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CAI0"/>
    <dbReference type="STRING" id="91928.A0A0D2CAI0"/>
    <dbReference type="GeneID" id="27328232"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01149"/>
    <dbReference type="HOGENOM" id="CLU_049912_0_0_1"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW20574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="327" mass="35382" checksum="1650C5FB3B2EA31A" modified="2015-04-29" version="1">MTDSDAVAAHSHQYNVSFSHDNTFVQYHDIDNNITWAEPVDDHDHDHDQFVPDSAPLLIALPQPPRKHVKRRSVGTPITSITTTTPPLSSVLRADITPIIPAPLRIRRPKHLSSTMPPSPARQVRLLIASIGNPPPYHTTRHSAGHLVLKSLSTHLSLPPLSRSKVLGSGSVSLGSDRDIPEYTLWQSASLMNVSGTGTLRAWKQFTSLSADGGSSQDTPTALVILHDELESSIGTIKLRRGETSAKGHNGIKSIQASFKSAGLLPSMGDRFIKLGIGIGRPQSREKDDVSAWVLGQLTSVEKAKVEAAAESVTAVLKSEVSRLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CBJ1</accession>
    <name>A0A0D2CBJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241110.1">
        <property type="nucleotide sequence ID" value="XM_016375834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CBJ1"/>
    <dbReference type="STRING" id="91928.A0A0D2CBJ1"/>
    <dbReference type="GeneID" id="27328556"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01473"/>
    <dbReference type="HOGENOM" id="CLU_060555_0_0_1"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="72"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="312" mass="34208" checksum="0CB3D81A8808E370" modified="2015-04-29" version="1">MRGIVSASSLHALRSSYRAKSLNTICKTAASRNIHQSIRIPAITTSQARRRPTIRPGHQRAPSSPAARTIYIQTQSTPNPSALKFLPNHPVLPETFPSTFLEYTSPRSTLAAPHPSPLAARLLDVDGVSSVFYGPDFITVTKEEDVNWAHIKPEVFSLITEAITSGEDIVNTFDKTSTTDGQEGAGEDSLAANDDDDEVVAMIKELLETRIRPAIQEDGGDIEFRGFEDGMVMLKLRGACRTCDSSTVTLKNGIESMLMHYIEEVKGVNQVLDEEEEIAMKEFAKFEEKLRQQKGPDAAPSTVGKGSLDYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y407</accession>
    <name>A0A0D1Y407_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_12073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847505">
        <property type="protein sequence ID" value="KIW09686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229902.1">
        <property type="nucleotide sequence ID" value="XM_016386380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y407"/>
    <dbReference type="GeneID" id="27339156"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12073"/>
    <dbReference type="HOGENOM" id="CLU_019095_0_2_1"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002236680" description="DUF7492 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="2">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="259" mass="27975" checksum="EC2F5E26409AE3EE" modified="2015-04-29" version="1">MTLLAGIGLLLCSLNLVNCHTWIEQLSLVDQDGQPVGDPGFIRGYVPRTTPGFVDGDNTYLLPQAPALTFQDSDLMCKLTQTQGNQSGGSVLMAPQGSSVLLRYLENGHITQPDVPPNKPTSGQVSVYATTQARDDDKFTAIHGQWTADKTGGDQRGLLLTSTPFDDGRCFQFDPTGHSEIATTRSNTFGPGPSITEAPNRWCGTTIELNDESGIPFANGTLLTLYWVWDWPSIVPGNPGTPPAILNETYTSCMEVEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7F8</accession>
    <name>A0A0D1Y7F8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231062.1">
        <property type="nucleotide sequence ID" value="XM_016384460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7F8"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7F8"/>
    <dbReference type="GeneID" id="27337228"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10145"/>
    <dbReference type="HOGENOM" id="CLU_292870_0_0_1"/>
    <dbReference type="OrthoDB" id="4158298at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clr5" evidence="4">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="695"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="730"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="955"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="989"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW10846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1136" mass="126198" checksum="3AFFC227AA2B7464" modified="2015-04-29" version="1">MPTVTLANSKLLDEHKDFIQDLYLTHGLRAKDVRQQLLALFSLQARYGNLQISSPPIPILTQCSEDQLKRKFKKWGIGKNGKKEDWVDAARRAKQRRLDVSQASITAKNGMPVDAARAKRAFRRHNLPRMEAKQANKNIQPCTSEEIALRRKFVNPNAITTITLPCHFYWEGLRKVLPYRGKSLPSNMLNPPSASFQSLNELYFTARNDLSNTTESLTALASLGSAKDASSLAVTELHSEAGKRSFAIARRLFTSAGSDYGILDEALTSEVLTVILPEQNQFINDMELVAYYPGIVDLPVLMSYLVYLCSNRLIQNGYFDNLADDLLDKYGNDALKYSCTEQLKYLRCFKEAILLYAARRGRYEIVQFLRPFILDLDQRLYTGAYPRTLLQEGIVYKQSSFCNDLLDGGADPGCPMDPLKLQVLLYERSAMDLAAYFTPELFHHMFNISRRKKSFTPTLLLPLAVKSGMAVADCLNLIDLGADINAMDSQGWTALQHAISAQQHRLVCVLLGLGTSADFLEEHRTMLGQYASLQRNFALPLSLAVEFDDLEICETLLRAGVNVNAYSFKPHEDLLARHYKQEPLANLPRAIFQTALQRAVWDNNTRVIQLLIEYGAKDTVENTIPCLIVATWRGNYEAVALLLQYGADFRETWHGSWLGKADAIVHASYGGHLQIMQALLDSGSHIGPTQETRGNGWTALQAACLGGNLAAVQLLLASGADVNAPCYCDDGLTALQAAIRCGELDLINLLLNWGADVNASPSRNGDTALSATIKSGSADLLRTLIAQGADVTFNGWNTRHDHDVSTIPIVAAAILDRIDFIQEMLQAGLNLNAPVSPGTRNTVLGEALSRAARNGREEAIEWFLQHNAPIIPSDLSKILFSVHFYQKFDSQVAKKLTQHLLDRGADVNALHVGETRSPTTILSRVCHSRKEDKELVQLLLDRGVDVNPDPGSHTRCEVPLIGAVSNGHIAIVELLLEYGADPNATTDIFRWTPLQHAASQGYIRIAQMLLAHGANVGAPTSDGHYTALDLAVAKGRLDMVKLLLDNYKLGDRQTMLEICRKYAEVAREECHWAILDLLESYESEAQRSISEVNYFFDADAVETGSEHSSRAVEKEINEQNIDFNPWETPDTPSWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y882</accession>
    <name>A0A0D1Y882_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231412.1">
        <property type="nucleotide sequence ID" value="XM_016384810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y882"/>
    <dbReference type="GeneID" id="27337579"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10496"/>
    <dbReference type="HOGENOM" id="CLU_572414_0_0_1"/>
    <dbReference type="OrthoDB" id="4112922at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="485" mass="53736" checksum="79B058AD7AFC13D6" modified="2015-04-29" version="1">MDFPAKSRFTFISDSRGQAAQEAIKVHVLRQRGWRIQKSKSGSKHRATKRGTLGGELLLWDFNPEPAKDHLPPALSVPPSPLEDSAVNVPDSTQQVASCGHSSTNLSSADLLSSPLPGETAESTENETQLVQQPSTPEDIVIEYYLYCNGPSKVPRAFLASFRKSKASFSAFLAASSSVFSYQRGTEPPLEIDVLENLAVREVMEQLAVSPSALSPGTIVAVALLANLQEWRNDPRLARLHWNGLKQIIDSNGGVSHLRVQEDIHTFLFWVEALVCNGETLPLGQTLPSSTHSEEGQTLLKEELAAFLERISSHMASLDPGFCCSVVPLPDAITEVLHRPCPNRADRYLFAKWQRAKLASLFYFAALSLQSSMGIADSYVLQTIITEVSQRGKENPVCPQELYHIILCKSVQPHLCHLSWLVSRLMCASKRLERRDLNTCYRLLSAAVGFSDKSETLDMVLDESRWLSSQLASRDFMQTFPEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8L2</accession>
    <name>A0A0D1Y8L2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231552.1">
        <property type="nucleotide sequence ID" value="XM_016384950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y8L2"/>
    <dbReference type="STRING" id="91928.A0A0D1Y8L2"/>
    <dbReference type="GeneID" id="27337719"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10636"/>
    <dbReference type="HOGENOM" id="CLU_563827_0_0_1"/>
    <dbReference type="OrthoDB" id="3903561at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="403" mass="44751" checksum="EF01CDC4C9D7BC9B" modified="2015-04-29" version="1">MVHLLYALKINRLIYDINVYYGQRQLAACDVQEVWTSWSTLFQINIRTGDLSFTTAKIVDIAFDLVVGRIGQAALAWLSYRVYTDVFTFLAERQPVPYTTFTAITVHPTSLSSLETYLLALFSKRGSKLTLLWLIGTVSYLLAFPTVVSASTSLVSATVSAIQLPTNATVPILEYLDSAAYKFANSGLADKPDPWFVYVSEIHKLPVKVSEEHLDIMYLDGTNWSGNDRNDTLVVNSTTYTISNSTLVDAGFYYGSVFYPIDPTKNHGVSALVGDQMVCIPDGNRYQWGASYELLCLIVICQILWSAAMLVVWSMACMSSATIQNGGNMGLYTAILLLAQPLREKMNKRPAGNDGVNNEKVVKSIVQTIGPVTYDNGFEAGGQERWARKTRGYARLREHMTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCS9</accession>
    <name>A0A0D1YCS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232972.1">
        <property type="nucleotide sequence ID" value="XM_016382269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCS9"/>
    <dbReference type="STRING" id="91928.A0A0D1YCS9"/>
    <dbReference type="GeneID" id="27335025"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07942"/>
    <dbReference type="HOGENOM" id="CLU_027816_3_1_1"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF697">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="64"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="487" mass="52211" checksum="28CE2909C4DFA0EF" modified="2015-04-29" version="1">MSIIGDPHPAASTATSDISSAGQDKMAYISEELARAETKAEGDLVDMETHEVFKKSVDGVEFRTVSWQKATLIFSKIEFAMSILAIPSALGALGAVGGGLSIVGWTTLNTYTGVLLGGIRNRHPECHTLADMMALVWGKWGREFVIVQLVIIQILVCASGIISTGTGLNALSNHSACTVVFNFASAAMITICSSIRTFSRLGLLTWFGFATFFISVFIFSVAVSQQDRPAAAPQTGPFDLGFVAVRSPGFIVGMLMTLNIFVSTSGPFMYLPVIAEMKNPKDFKKATILAGVIVGIIYFTFSMVIYAYCGVWIASPAFGSAGTLFKKISYGVAMPGLVIGVGLYQHVAAKYLFVRILRNSRHLQANTLVHWGTWLGVNLCLGTLGFIVAEAVPVLNFLLGLSASLGSACFSLIYPIILWANDFREYRTGTLKQKANYVFNVSIAIIGVFILVGGTYADAISIRDAFRSGFISKVFDCADNSGSVATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDQ5</accession>
    <name>A0A0D1YDQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08358</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233387.1">
        <property type="nucleotide sequence ID" value="XM_016382684.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1YDQ5"/>
    <dbReference type="GeneID" id="27335441"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08358"/>
    <dbReference type="HOGENOM" id="CLU_000935_1_1_1"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057068">
        <property type="entry name" value="IML1_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24438">
        <property type="entry name" value="IML1_N_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="DEP" evidence="8">
        <location>
            <begin position="1297"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="820"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1381"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1639"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1758"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1833"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="882"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1401"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1643"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1671"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1836"/>
            <end position="1845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1891" mass="211174" checksum="3DF31D54FF80B9CC" modified="2015-04-29" version="1">MKGSSIHRRTSSGSTVKAAGRTHSALSNGGTAPRTKPTVRATLWIHDDNFSTEDVLVNEAFLEGTDIREGSLIEIFRTKETSDVRDFQSPVTETEDAAFNVSGRPYAERDADAATRYLCVAKYAPLDLTARQAGLQVSVKTNIANAFGLRPRSQVWIVPASFEERTASHVEFNFRDAYLARSDMWRLVGQELTGRTIYTGQKITFLGTIKLTVKSIHVQSHKVAAGYFSGTTIPIFRSEAARYVLFIQMSSEMWDFDSEGNGEIMFNRVINGFLPDLFKRWTDLDVRHLVSIVMFGRLEYDRFDLARNKDRRMETTSATGAPNMTARQYQDFYRVVVTDMASAQWTTILNELKRDFRVFLRDISLHTSVNNEIAVKDAKANGTRIAGRPSTALKGNILEAINIASTQFANDFVDRDLIRTGISIVVVSAGTGVFEVDRDLLNLTSQNLTNNGVGIDIVCLSRMPLHSVPLFKYRISASEDSAQSLLTSNVNISPRRSGSGPALYDSSQPRKLSPALSSITSNSLRHLTSYISGETHAGVRGWCFGIPQWVDLSYWSAEDDQIDALAREDEPKRKKRPFVPRVRMYEIQMMGLMELGLADMRIPFMSESQTLTLGKTKHYKYKDRRASAARCLSHSPTTSRKTGSRLDPKIHYRGLLSTHAKALGDIFERMERYDSMLYRSRPGHQLLSSSLKQSSSLEKSAAFVTSKLDNESQARIGESVTGPKLTKVTSRKAPNSVFRPQLPSVLSADASERSFVKQSPAVPKVNRNLSYSLRGLAPPVRSVPSTEVNTTNISAQPLMSMLGKSKPTVATSAASIRSVSTNSLAGDRETHLQHRFGSPRTTSSNRASGMPSKPISINTPFRKHHDDRIAQSLRSNSTSRHVSHDVEDPKNGYETERESGSDRSASSASDEDANDSAEAADSWMGTSIASSVPRSNLPYVRNVNASNPLKRHPERESYYGRWQHLYPRKPRAAIVKWRSLCTPASVPLTTSDFPSKQDLETEYESTYYDVDLRVPNDMLEVPESRDTLLREMLALRFSHGYQLVVGPSLVDSVGPGTCDSSSFFTPGLVRPDGSFIFLSMGNTIQKLSLERSDRIRVTRYVRKQPTVEPPYPQHVNYYPNIKTILSENYMIRDMQFKGFSEQYPWAQADKYLSDMRQHAEADTTALRFWRARFVLIPVEPPHTARRPASSEGEENEEEIHLRGIRVLTQMWQKARFVPLDERRPAHNRLSTMKRKDRNPLRINLETLNPSELVATELDKLIAAEEAGELQPTQLLPEEEQFDRDSFSLSKLAQALQGDRGIEIKTRRWHLRLHYSCFMGEDLTNWLVHNFRDIETRDEAVEIGNDLMKEGLFEHVNSRHNFKDGNYFYSIKPEWRIQRPENKPSWFPTSRRPDRSIPATPISEQTPRETTTGRTRSASSLANQAQITSELAKSLGDKKKRAITLSKMIRIDVDMRKRSNRPEIVNLHYDRLHNPENCYHLELAWLNVTSKLVDDAIVNWTTQAEKYGLKLVEVPIAEASRVPDHEPFRAPYRIKLAVEPPQRVVASNVYFTATSFGPQAPLNSDVHLYQKALLKRFNFVLDLEAACEFPENVEIRYSWGTLDYRYTQFVHRSGVCLAQITDEGDIILLANRLYNSRLASAKDTSSRMDSTKKEVTPSAAAPSSAILRPTPSMASSAIINSNNSYSHNHNHGTSSSVPSMQASGIIGLNVASPRTAPHSSPLMRPLSNITPMGTPGAGMSTLSLSSMSMSASASATATSASGSNVTIPPPPGALPPQATADVLGPNRQSLLLSGAAAGQYITPEQIKDDIETFCHDKDTLEAFYRDVSATLPQLVNQRERERERKTGGSTGGAGGTSSSLLRPVREVTVEGELGIPEFKLPEAVTGRRTSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YGC4</accession>
    <name>A0A0D1YGC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234247.1">
        <property type="nucleotide sequence ID" value="XM_016381145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YGC4"/>
    <dbReference type="GeneID" id="27333895"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06812"/>
    <dbReference type="HOGENOM" id="CLU_2084865_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="117" mass="12711" checksum="5E5EDA2057AD0E24" modified="2015-04-29" version="1">MSNAPAAATTTTTNNNNNSAAAAEKKAKKAERRRRQQRRRRANKAAKKAAAAAAEAAAAADDDEEAEEEPVAPGPEEEEKPAAKDGEDTVLPDRTFLQRLLQQPQLRSRLTTMRTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YH92</accession>
    <name>A0A0D1YH92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234537.1">
        <property type="nucleotide sequence ID" value="XM_016381435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YH92"/>
    <dbReference type="GeneID" id="27334186"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07103"/>
    <dbReference type="HOGENOM" id="CLU_054588_0_0_1"/>
    <dbReference type="OrthoDB" id="5378679at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="392" mass="43445" checksum="F526C7E02B3C46B5" modified="2015-04-29" version="1">MTRMIVLAGAPESNKLDWNEKLSLPNSMHIETATATTTSSPPSPSSKAFGAQWRQITTQRLQMRPILPKLNIDARSPPEEFERRGADFFSADEHAGSQTPGSDESCDESQPSGSSSEATSEALSEYYEHSFAIHEAIPSSQLSAFSSYTPGTPTYESSDEMFPQTPGGGIIRTPSQRRLSQAPRPKHLSDLDDIPNARYLTSIEPQTMTVNLIVGILSISPARTVITGAKYGRPRETELVELVVGDETKTGFCISMWLPREMHVNWKDGAKATPEGSRSVLRRSLRFMRPRDVVLLQNVALSSFRGKVHGQSLKGDVTKIDLLFRKKVDDDDISGIYTLSNLRTAKDPQVLKVKRVKDWMMDFVGDGGDQPRASKGRRRGRNDYGFLPDDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMW8</accession>
    <name>A0A0D1YMW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236607.1">
        <property type="nucleotide sequence ID" value="XM_016380780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMW8"/>
    <dbReference type="STRING" id="91928.A0A0D1YMW8"/>
    <dbReference type="GeneID" id="27333525"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06442"/>
    <dbReference type="HOGENOM" id="CLU_006331_0_0_1"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="551"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="913" mass="103214" checksum="F0EBFFB59FAAF3D5" modified="2015-04-29" version="1">MAPPILYDPFSSDAITVIPPLAGDAERVWDGFQFNSRLESGLFRLNETKSEIPDLETDILRLQLEDVPLLNLSAPTSQTTSDDEDDGSSEQKADNAEDDVESLWTLPEVTGRRRVIELLSWDTFLDRRHSEPVSGYLSEAGPRAFSSILSASRSAMSAKGLKPDVLLSAFYQLLMGRSSAIFVWDEKQHAFRKQVDHLVAFGYSHQLLQDLFETISRVGAFAKVISETCTFSTGRSSPCRIAFGASVLAALYSVHEYLETTRPEITTMVRLKSIMTKVEVLVTMLNQCAALVQNYKTEESLLTGLMTHLTAMSSCDSRVVAVLQSIFSSSSQPALAKLSAEIGLSSSGPTGDDLFLSQISERHNMWTSILQTEMAEVVLETRESLRLLRLYNPECPVLSTSEYGNSKLSTLEIVYAFNRLCILHSRSSAYEDVRKSSISSTGSSTTTSLLVTPATDSFELSDLDIDRSEPEDPFRFNTNLFEESLDTIKNLNHDDLHSHVLSYLRESEHDENPLRIDIDQALPLSISPLLSAQHRVLSYAVLELIFQQYDLIEHINLQRQFHFMGNPSFSSRLGTALFDPEQSTGETRRRTGVATGLRLQARDTWPPASSELRLVLMSILSDSLSKGQRRNLDDCISFAIRDMPLEELEKCRDVDSIYALDFLRLQYKPPNDVLGTILTTQILDKYDRVFQLLMRLLRLHKLTESMVREGDSITGGDHKLIFEMHHLITTLADYYHNTTIELHWRKFDSVLQDVRAHIVKKDYERTLRAVKSQDYLRALHERTLDSILDGLFLRKRQSKIQQSLEHIFSTILAFAAHRRKEQKPKDGKPADSSEKGFRSRFTEDVKRFVAALLSQDQKQRSASYATETMPSGDADEEVNLLECLLLRLDMFGYWDRGGRAKGISHLDLEFALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNM2</accession>
    <name>A0A0D1YNM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236917.1">
        <property type="nucleotide sequence ID" value="XM_016378240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNM2"/>
    <dbReference type="STRING" id="91928.A0A0D1YNM2"/>
    <dbReference type="GeneID" id="27330972"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03889"/>
    <dbReference type="HOGENOM" id="CLU_037990_2_6_1"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF89">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="286" mass="31453" checksum="ADCA55C06FF40294" modified="2015-04-29" version="1">MPSSEAVVSEAINHYTSRAGTYDAATGGWHAVLGCDYVDFLPPPRGGAVLDLACGTGLVSLPYAQAVGPDGVVVGVDITDAMLDEARQKPVPAGSGAVHWVKADVADLSSIDAVQEVRRERGGFDVISCCSALVLLHDPAACVRHWATYLVPGTGRIIIDVPTEDRTLQKLFTVSLRKSLGLPNLFDREWIRDIHSLEHMYEGAGLEVEESFRTKSYIPERVFGLDEGMTVFEEASTSTYQWVRNSTDLLARARDVWPVIWKESLNDNEKHRDGHWLYVTIGARTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNU1</accession>
    <name>A0A0D1YNU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237007.1">
        <property type="nucleotide sequence ID" value="XM_016378330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNU1"/>
    <dbReference type="GeneID" id="27331064"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03981"/>
    <dbReference type="HOGENOM" id="CLU_1906768_0_0_1"/>
    <dbReference type="OrthoDB" id="4120903at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="161" mass="17909" checksum="E8E9A7DDE74378CE" modified="2015-04-29" version="1">MPPPSNLPPPPTPHPLRYAQDAARSIPGNNRKSRPLTYALGIAGIAGSGALIGAILNMSSQRQSQQNQTPLQPLPQAQSEGQAESSQLHLQPQSQPRAHLAPGVDYSQALQTLETKRGHLMAQKMQLERRINDLHETRRRRQQQQAEEEHEKERDSGQEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPS5</accession>
    <name>A0A0D1YPS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isovaleryl-CoA dehydrogenase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_04412</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237437.1">
        <property type="nucleotide sequence ID" value="XM_016378760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPS5"/>
    <dbReference type="STRING" id="91928.A0A0D1YPS5"/>
    <dbReference type="GeneID" id="27331495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04412"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_1_1"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000021">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase IvdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="166"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="274"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW17221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47224" checksum="E8AE98803F9AC280" modified="2015-04-29" version="1">MVSSLLPRIARPATHLARHAPRLLCPHTAVRSASTSKSKHPSGFTPPSREDLYELRERVQEFTRREIPEEIAARTDSVNEFPDEMWKKLGEAGFLGPTADEEYGGLAMGYQAHCVILEELSRASASIGLSYAAHSQLCVNQLCLNGSKEQKERILPGLISGDKVGALAMSEHSAGSDVVSMKTTARPVDGGGYKLNGTKMWITNGPDADYIVVYAKTEPEKKSKGITAFIVERGFAGFSVARKLDKLGMRGSNTGELVFEDVFVPPENVLGEVNRGVTVLMEGLDLERLVLSAGPLGIMQACLDLVLPYTHQRKQFDVPIAHNQLVQGKLADMYTKLQASRAYTYETARKVDEEGEVRTQDCAGAILYAAERATECGLDAIQLMGGNGYVNEIPAGRLLRDAKLYEIGAGTSEIRRMVIGRAFNKEYKDQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YR15</accession>
    <name>A0A0D1YR15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237902.1">
        <property type="nucleotide sequence ID" value="XM_016379225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YR15"/>
    <dbReference type="STRING" id="91928.A0A0D1YR15"/>
    <dbReference type="GeneID" id="27331964"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04881"/>
    <dbReference type="HOGENOM" id="CLU_046066_1_0_1"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF13">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="256" mass="27289" checksum="E2F44A290CC4E77D" modified="2015-04-29" version="1">MSSKPAILLVTGSFSFAGMYYPLQDAIKAQGYECFVNNLPSATRNPPEEPATLEDDAVFIRGIAEKIADQGGKDIVVVAHSYGGVVATEAAKGVLKADRQAAGKQGGIVKIVYLTAIVLPVGASNFKDQGDPPAALVEVGEDGFMKITGLEICAGATFNDWDFEKALVMTKSMSKHSFPSFKSPLTYAAYEHVPTAYVFCEKDMILPPEKQRQFIDQIKAGTGKEVEIHTLDTGHCAPVTAVEETAKVIVDIAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YU53</accession>
    <name>A0A0D1YU53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein BNI4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239007.1">
        <property type="nucleotide sequence ID" value="XM_016377437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YU53"/>
    <dbReference type="STRING" id="91928.A0A0D1YU53"/>
    <dbReference type="GeneID" id="27330163"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03080"/>
    <dbReference type="HOGENOM" id="CLU_011525_0_0_1"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="81658" checksum="7D88F0D2598A3CCD" modified="2015-04-29" version="1">MAALVQTLPAQTTTVTMIGRPSSSGGYPSHTSQGQMRNHAPSRYNNVPTAGYRGVPGSGPIAPYAFTSTPQLAAFNNNARSSAHNQGRSWPSPSSPPETPTTLPQIDFGGRPLSLGLPAIPSTGSLMGMSTNLAPPVTSTAPKPSPDRYRRTGRRTEVESHVNRPASNPAVPSGSGMAAVGSLYHHPTQSSSTPSLGSQQSYRGSHGNLASMGHSSADDLTLAKPQTTELAARYRRRSFGSIETAGLNHTSDAQDVSSPHPNSFLPSPTAQPTPMSAQRPLHKHTQSSDSVASSRSTHSSRPSSARANYSSPSSPVSNPSPGPSSKSDQRLGVRSARSGDSSIRQPSPLSRPTNLQADDIEAKTKMPSAVPSQSHPVSSPAVEQLAALNQKNGLKSKSKLRRAFSFGSAAELRKATTQGNHEKSVANRTATASKRSSKYEDELEPEQAKIAEKQEAAGLGESIYSGQGQFFTGSTDNLSISSTASSASVMLRKMGKGVKKGTRSLVGLFRPKSVVGVPAADGPVNQASLAQVSMVTVEAEREKVNININPHDQTGGGTGFPKLERNSMDTKLSFDSGTVSSDTRSRRSIVGGERERAEVLAAVKKGILKRVDSNQASPKLKTYDFKVPDFNLPQIPHVNDSPKSSAPSTPADETPRSGHRRTDSITIESNDHDDYFSSMTRFVNPETKENPMTPQSLIRNISFSPRLQFYDTWPSGEYDRRGEIATCNRLTPMLAQQIKEELNTFKMEMEVHESSKVYTHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUP5</accession>
    <name>A0A0D1YUP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spt20-like SEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239187.1">
        <property type="nucleotide sequence ID" value="XM_016377617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUP5"/>
    <dbReference type="STRING" id="91928.A0A0D1YUP5"/>
    <dbReference type="GeneID" id="27330343"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03260"/>
    <dbReference type="HOGENOM" id="CLU_004682_1_0_1"/>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="2">
        <location>
            <begin position="113"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
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        </location>
    </feature>
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        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
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            <begin position="232"/>
            <end position="245"/>
        </location>
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        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
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        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
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        <location>
            <begin position="527"/>
            <end position="545"/>
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        <location>
            <begin position="562"/>
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        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
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        <location>
            <begin position="698"/>
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        </location>
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            <begin position="755"/>
            <end position="777"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="784"/>
            <end position="825"/>
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    </feature>
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        <location>
            <begin position="921"/>
            <end position="934"/>
        </location>
    </feature>
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        <location>
            <begin position="935"/>
            <end position="988"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="988" mass="108461" checksum="938A095E91C91E6A" modified="2015-04-29" version="1">MAAVATKATGTATKMKKPPAPTLQTNTNGTKPAAPSSSPSGARKTLPGQGQTPTSASSTGAGVNGTARPNRRLQRLNTRNSTTDATGSDKRGTKKFPEPYVPKESHILRKFKGCPPSLIVHLHPTHFRFDQQEGSFSYHSEMRVFIEHLAKGTIPHDMVEEFRKSEVKYYDGWLIVRVLDYKSVAKDAAANDASVGDEKPFSIHNYNHFITPSPYVPYPTKEQSVARSPPTKPEHQDSISGDLKETLNSDDTIDVAPKTTKPKPKIYHVALRPTILSKHMDLVIDAMTPDPKSVNRKQSQVNSSNRAPGSAVPQTPISGVPATPTTEKGPPHKRLKLKIDPKDLVDYEARVVNATAPPLYLEAVESLEEAETLMEMLKDPYHDARPPSPKSRKRTVAELAAEDAHAKEQERFMLVMDERTSGASGAPNTGAVDGQAAAALFQPRFEKFNALDNIKREIAERKQREKDRQLQEDENRRGQQERLQEEEKKRIMMQRAQEARVIRARQQEMQAALAAQQQTTAQTNQRPPSQQMNGIPPNMQNQIMAAQQPRGSPILRQGTPHAASSPVVTSAPAQGGLPMAMSGSQQGHGSPARPGSAVQHAHPTAPMARVGSGQAPSRNGTPQLAHGTPAGGIATPIIRQGTPGQHISQASPHSSMAAPTPQMLPNGMIQGMQGQMMNGVQRQPNPQQLAEMQRRHAMQQQAAAQQAAMHQQMINGTPQMAQAQMAHMQAQHHAQMDRQAAMQRQQAQQQAMQQGTPQSQHMSPVSAQSQKAYNQSVVEHVKAQMQSLQQPHSQSSPAQNQMTPQQQAAQMAQAQQQQRMMAAQAQAQNQMMGGNGPPQQRPQINPQLQQFYQTTLNAYTQRFLGQAASKYGGNTNMLQPAELQQVQAQAKQAALTAVRKRQAEMSQVQMQQAQMRQQAQQGGGGMNMNGGGMGMNVNPNMAAALQQHQAQQMQQMQMQHAQQMMAQQQHQQQQQQQQQGMQFQHQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YW91</accession>
    <name>A0A0D1YW91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239727.1">
        <property type="nucleotide sequence ID" value="XM_016374451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YW91"/>
    <dbReference type="GeneID" id="27327166"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00083"/>
    <dbReference type="HOGENOM" id="CLU_030107_0_0_1"/>
    <dbReference type="OrthoDB" id="5329403at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="617" mass="67135" checksum="E1BB8C58DBC4F851" modified="2015-04-29" version="1">MAPNPKGRPSKPHGRMVQPALPLIPGPKGKQNNKPAPAQVESEKIEPALKTSDAVNGGNQEHAEIVEALAKAHDVTTGGGEAEHVEDRALTQGSPIDTPQKPLTPLAQTANDNEPEDNISAGEDSLSQMADTQATSQDVSGHTSEQETAVDEQETVNLTNGHLANVSQPISSASGEDYDGQASALEPFAQVANERPTGAATANGNGASSSPQENGHMTPEETQPYGADQPEQVYGSNAKSQPEVNGVYDPIARKSSIPESVQQPRVSPGLIPLQDYLLQVSHTKEGVDWAIQVNPPGVQPYLLYAHSLLMLRSDRLRRLMQREPSSAYGGNIIHLYPARNAVPHAFDAALRFLYSDTVLSHLIQPHPGPDFHAARLQNLDYILSYWVAGIELGIDQVSACAERLLFNYVDWDILEVTYKHAIDLANSPVVSSRKNTTGSDYVVVSNAVIRPILHFLAARMDVSKFKIDLTGAPVHFPTRFPTVDGGRLKHKPALASMVFGSMPSSADMSPTSPQSEIVPATATFRDTVATNILLNIDFEHLFYFNSILQRSNIAGASQLMSSIITEREVRRQKVRNSRAVANKDRMANSTAWEVVGWKEEWDTETNLPKRERVGFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXT1</accession>
    <name>A0A0D1YXT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_00651</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240292.1">
        <property type="nucleotide sequence ID" value="XM_016375016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXT1"/>
    <dbReference type="STRING" id="91928.A0A0D1YXT1"/>
    <dbReference type="GeneID" id="27327734"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00651"/>
    <dbReference type="HOGENOM" id="CLU_008243_0_0_1"/>
    <dbReference type="OrthoDB" id="9368434at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="454"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW20076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="816" mass="89931" checksum="A221ABF91EC5D900" modified="2015-04-29" version="1">MASTTMPPPPTPFAHRRTLRLINKSHPLSPPASPDSPECVLRKMSLAKGATFHCSSSPSTEDDPVLSIPHLTRRSPTCSASTLTSWLSEKEDVAKSIADFEETFSGARGKRSGGRRRSSQNFDRLVWVRRAALPSDEGLGSSVSPASDKGLARTFERALDLLSNKDSGLGSSIKSDSAGRVVGNTSEEDGLVQDLIQEADSSETTSRRLRHRGLTSTLRSSNAAPSAVTESVAPRPGRASLRHPPLTVSARNKLKQHIISPILQETRFENLHPFVTALGSKSNKKIKCLRDLEQSLIFQPLSLAISRHLYRAFGEFTIQLVVDAYQHLSESEQRRASDRPYDNGYFLDLVQQVNRLASHIGSSSSNPLAEGAEENDEMAYSIDDEVTLEGGLGETGNHAELVRWKNGKGISLRTGLPYEPSPGIKRESSSAHDEDVARSMARRKKGYIPEIVEMKCSDPTCDKIFTRKCDLAKHEKTHSRPFKCPEEGCKYHEMGLPTEKERERHWNDKHSKNPQFYKCDYCEFRTKRESNCKQHMEKKHGWHYERAKGKDKATVGSGKMTPAQTPQTPSMDYSASPAISTSIHSHWDDASSIAGSISASAVITPYEQPLNNFDSYRPAPVSYSNPIFPRNPPSMSYNQSADDFDFNNTPYSNAFQPAQAYISPTNTTPMSAANIMGTPITPAYSNITEPSPYDTSMDLMMDCTNPTIFNEGLPTPSSFLVPQSRNPSISEHSPMIAGPSGQPFGKAPMMGQEFDFPVEDFSLFGGEDSNAFSNPAAASATLFPGGPEAFAALDNDPMFDESYNDDELFDWDMTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YY47</accession>
    <name>A0A0D1YY47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240422.1">
        <property type="nucleotide sequence ID" value="XM_016375146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YY47"/>
    <dbReference type="STRING" id="91928.A0A0D1YY47"/>
    <dbReference type="GeneID" id="27327864"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00781"/>
    <dbReference type="HOGENOM" id="CLU_014148_0_1_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="803" mass="91309" checksum="2CC8F36D69CF4765" modified="2015-04-29" version="1">MLPSSHVKVNEFEQKGDDPSTRVAEPDYMEMEGHQVREELEELDRELAILREGPFGPNSEFMRSFPPDEREALLKALEEEGVMPPTTEDLISDEELEELARDEEGTKRSAKAKNSLKVTLSIPTTHKIYVKRFNKALQEAEKTNADEKSYFALWKWYLRCQQHISNFAAIISEDVWHFLWKTQSTKYYRPRHLQMLARDMMSADIQFEDKELVQYIDALQAVGDFATAAEAWEEHKTRLGNKPDLAATFWMTGVRIYVDLGKPQKAQSIAFECYNYTTLVDPEVLVLVISAWAKSQNGFAPTKTWWCYLELRRILERNEEDGQKILNILGRISGTLLEAGRTELALAVFKDMYLFKHKKANDSWSFFKDMVETLQDTQLPGEDLINKVGLASFVFLPRSYQNKFFFGSWIKWLIGADRVDEAAVVVELMYERGVKPDAGHLNGLIAGYLREGSPTARQTAESTAWSMIQARVDMVRKRDIQRNENASTAPEEPSSVQRRTPSFLRRGAPPATVETFSILLQYYTRRSELAKAGELTDVMIGSADIKPNSFIMNHWLYASLRSGDAHEVWTKYIALTETIEPDLETFAALWDTAKASYAAAATGDKGFPGARRVFAEMQGWIASASSQRRNAAQNDFSHELYEQIIRCFCLSSDAKGVLCAMYGLRESFGALPQEEAMRLILISVARSFGVDFTSHLHTRDRGLRASRKSQYQGALHTLTNIFVSILDRKLVDADMDPEELGDAESPQAQELRLDALSTFLCMVIERKLERGDSLLENVSHVADEMNVSIPEEVLTRHDWPGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYM7</accession>
    <name>A0A0D1YYM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240607.1">
        <property type="nucleotide sequence ID" value="XM_016375331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYM7"/>
    <dbReference type="STRING" id="91928.A0A0D1YYM7"/>
    <dbReference type="GeneID" id="27328049"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00966"/>
    <dbReference type="HOGENOM" id="CLU_025640_2_0_1"/>
    <dbReference type="OrthoDB" id="5422510at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="479" mass="52453" checksum="1D696F3ABCB7E7C0" modified="2015-04-29" version="1">MASEKKPSITLQPSTQTTHRDSPSPHGLRLRPLGRASTFAEDNNRSGRRSSSFISETLSETRRSLRTSTDDILLPRLKDGDDIVDNDENSNWQSLPLGLALLPAVGGLLFKNGSAVITDITLLGLAAIFMNWALRSPWDWYRAAQTQATPGSSTPPVFTPVDEEDDGLEPAGKPVGGEGPTLPSSPKSVGLGGLQAEKAAARKELRIYELVALVCCFTFPLLAAWLLHGIRSQLSRPSEGLVSDYNLTVFILVSEIRPLSHLIKMVQKRTLFLQRKVSSDLLADSRRVDNQQLRDLSRRLEELEAHVADGIDAETPQIPEPVGKALDAKIPAVVRTEVQKTVQPEVDALNRAMRRYEKRTTISAVQFEARLQELEARLNDVVSLAAAVQRNADRKTDSYLLTLTNWACATVVVPAQHLLHLLTLPGRIANAVLAMPKQFFSKSTKSSGPKDARAARRSAPPRTPGDREKRIKGSPLTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0W4</accession>
    <name>A0A0D1Z0W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241497.1">
        <property type="nucleotide sequence ID" value="XM_016376221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0W4"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0W4"/>
    <dbReference type="GeneID" id="27328944"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01861"/>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000035">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="191" mass="20729" checksum="9C9E6B1AF09B814E" modified="2015-04-29" version="1">MAATPIPVPKPGEGEPIVFFDITLGGEPLGRIRMHLFANTVPKTAENFRQFCTGEHKVGSRPQGYKGSKFHRVIKSFMIQGGDFLHSDGTGSTSIYNNASFADENFTHKHTRPGLLSMANSGPNTNGCQFFITCAPTPFLDGKHVVFGQVADDESMKVVRMIENTRTAGPGGRGQGERPVLDVRVSECGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z1X7</accession>
    <name>A0A0D1Z1X7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241882.1">
        <property type="nucleotide sequence ID" value="XM_016376606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z1X7"/>
    <dbReference type="STRING" id="91928.A0A0D1Z1X7"/>
    <dbReference type="GeneID" id="27329329"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02246"/>
    <dbReference type="HOGENOM" id="CLU_081905_0_0_1"/>
    <dbReference type="OrthoDB" id="5400774at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26533" checksum="C3F00D54DA17D290" modified="2015-04-29" version="1">MDPRPSSYEPFRHGRDKYDADGHMNAVADDETLLKQEDYTRQPHAVDQPCSKGSHHHKDRPPRARFQASRTVFRVLSLVLTITILGIQAYSLYLWLKTQHMTAKNKTTGFQTKIWAVVDTRPTWVMIGVAVGAVGIHFIAFGSLCGCCQSARSGAIYIWSVYLSSSLLLAAWIAALAYFRAIDSMGDKKTSWDIWSWSCNKRSAKGDAVTWNALCVKNVRSNSKSDFILIQFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAT7</accession>
    <name>A0A0D1ZAT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230343.1">
        <property type="nucleotide sequence ID" value="XM_016385399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAT7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAT7"/>
    <dbReference type="GeneID" id="27338170"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11087"/>
    <dbReference type="HOGENOM" id="CLU_1981625_0_0_1"/>
    <dbReference type="OrthoDB" id="4117870at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="126" mass="14267" checksum="67AD341A015F0798" modified="2015-04-29" version="1">MANWSSTVPAGILGGLAGVMLLFIWWWFPRTWNKGVRQDNDRLDDVELQAQRAMVVQNARDIVDNYREVLKQRELTKNANIQQSTDTATEGRSIVTESTAREEETDHARFDTNPPRPDGRPGGPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZCK1</accession>
    <name>A0A0D1ZCK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_10066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230983.1">
        <property type="nucleotide sequence ID" value="XM_016384381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZCK1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZCK1"/>
    <dbReference type="GeneID" id="27337149"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10066"/>
    <dbReference type="HOGENOM" id="CLU_016969_0_0_1"/>
    <dbReference type="OrthoDB" id="5419927at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="236"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="459" mass="50992" checksum="EA3F80954AB4541D" modified="2015-04-29" version="1">MAQREYDFCHGSQHVGKFRRKLRDVLNKANVPLQHGMKIVPSVDITSPVISVINMFLDGYCQAAEVREIVNSEFDYLPACFARIDFYFKTYPNDHNILTSCVNLGFTTFKGVEGAVGFYTSYQAQRAGLVILSGPKYQQNLRRCLQEIKSGSDALEDEARMSFTHRMISDNEQTRNWPPRSPMSSRSTTPRLGEAPHWTPRDMWTRLHIPNLDETNLHNVVDSAADIVFQDRGRADQVIETPLFRNWILTPGSARLLVHGDFSGVKKVPPSSILCATVMQALRMTPGIVLTGCHLSLDDHHGGTAMLRSLVAQLLRQFPSFSIDPDPGISMQAIGNGDADQLCRLFVHLVRQLPPKTTLFCLIDGINEYESEEYLHDMDGIVMALVDLVEEADNNTRAKVKLLLTSPQPTVEVRHVFDDVPEALLHVSQLPLVGGGVGFVGLQEQLGGGIIGEIDAGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZG76</accession>
    <name>A0A0D1ZG76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear transport factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_09246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232188.1">
        <property type="nucleotide sequence ID" value="XM_016383565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZG76"/>
    <dbReference type="STRING" id="91928.A0A0D1ZG76"/>
    <dbReference type="GeneID" id="27336329"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09246"/>
    <dbReference type="HOGENOM" id="CLU_020422_0_0_1"/>
    <dbReference type="OrthoDB" id="5300765at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="6">
        <location>
            <begin position="603"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="721" mass="79826" checksum="F0C8CDBDB6743E75" modified="2015-04-29" version="1">MSLAPYYYRPLTPPEANGAAGQRGHARNLSASSYCTADTSPESVITATTAASTPNRSPVLRQHGPTLLPKIRSQDSADSRHTTRPSMHRRTLSYVNNAKNARPAMYRSATEPVENAAMMSPESNAPHSRSNSSMPSPSISKVQLNVPVKTHSRSASASSIDNNVLNRFGYPTYRQLPLYLSHDQQTPSPDMFATTYMPYTNIPMPEPPMINLEGTFDMPIDLDIISRPCSMTPPPMLAQASTTSMLSYLSQPTQPINLVRHLTYQTGRGLTNHFWWDVRNVRPWKSFSIQTMASIPDLLTLLNFQHDTASLPFTNSNSNTVTPASEVDLANLISKIYFPKVNAATRLSLGNNSVCLYPSPAPTASGVSANAANVPTFLANYPTDNDRTLSGLPRGRVVGLVRSFDRWNTGMRKEGPARKVEYLRTLAHLQKCMRDHSCRYGFIITEIELVCVRAGCDERDQPYFGLLEVAEAVETKTFAVNGGNLTGRGDISMTVTLALYYLLMLSKATPLPGEPGSYMDVGGSGALSRQRVWDGGHGTAAGAIVIDEDGDIEELGKDGKDKWIPEPQMGEKREARTVRGWVWPSDPWHKREGERGERGTGRGREQFVEFYYKTFDHDRTQLAALYRNNSMLTFEKEPFQGTQSILEKLTNLPFQKVQHRVDTTDAQPSNEQGGILVLVTGALLVDDQQHPMSYVQTFNLLPDAGSYFVQNDVFRLVYAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZH80</accession>
    <name>A0A0D1ZH80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Linalool dehydratase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232508.1">
        <property type="nucleotide sequence ID" value="XM_016383885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZH80"/>
    <dbReference type="STRING" id="91928.A0A0D1ZH80"/>
    <dbReference type="GeneID" id="27336652"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09569"/>
    <dbReference type="HOGENOM" id="CLU_044865_1_0_1"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041411">
        <property type="entry name" value="Ldi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18566">
        <property type="entry name" value="Ldi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Linalool dehydratase/isomerase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="475" mass="53856" checksum="397878F18C4CFFC2" modified="2015-04-29" version="1">MAYATGVAHYHRLPAMRTAFKSLLRRIIHKMLRREVWGYWFTTSHGGKLLDPDLKELRKPWADPVIKENIMYSGHLLLMTSLYAMLFDDDEFEKEGSLTFDWNPLFWGMGPEKFSYDNRSLQKVIFQQMEDNDWVGVCCEPNAVFVVCNQFPIIAMRYNDSRDGTNNVEGVLEKYEASLVAKGMLNDSGLYPSFFAIKQRAPRPARQGAHTAWANAYMNTWNSEKVHSLYDSQVLGFLTTIGGKTRLQPTRVSSAFRQLVLEKGKDPNSEETLQQARELSPQFVSPAFPFESVNWNGFTQMLSELGKEKELGDLLEYADSYLNPTWEDGGLYYPRNDALMDKEGNLIHMEPHSGNSGIGYSRLNVRDGQKKMWEQPWTRETLANRPFVDDIGFADGVDFLRGVWDAEAHALVVTLKSWSGQSAEVSFSVKHLRKGDWAVYVNGGLQHTTTVKGSGSVDVNVTVGNDEVDIVVSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHA0</accession>
    <name>A0A0D1ZHA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232528.1">
        <property type="nucleotide sequence ID" value="XM_016383905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHA0"/>
    <dbReference type="GeneID" id="27336672"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09589"/>
    <dbReference type="HOGENOM" id="CLU_013985_1_2_1"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000047">
        <property type="entry name" value="Acetyltransferase, GNAT family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF2">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="250" mass="28871" checksum="4622FD261194EC0C" modified="2015-04-29" version="1">MASHQKTQWDQDIGPPVSFPSAASRPGRVELTGKTVTLQPLAPRHALDLWPEIQDEKTGHIWTYMGDEPYRTLEAFQRAVTTKSESTDLVFSAIINNQTHKAVGWASYMRIDPTNRVMEVGNILFSPSLQRTKAATEAMYLMMKHAFEDLGYRRYEWKCDNHNRPSKRAALRFGFTFEGVFRQHIIYKGRSRDTAWFSIIDTEWPTVKNAFEKWLDDSNFDDNGTQLHRLEDFRDAMPAQKGPITLEGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIQ1</accession>
    <name>A0A0D1ZIQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232948.1">
        <property type="nucleotide sequence ID" value="XM_016384325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIQ1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZIQ1"/>
    <dbReference type="GeneID" id="27337093"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10010"/>
    <dbReference type="HOGENOM" id="CLU_296586_0_0_1"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053110">
        <property type="entry name" value="Ribosomal_L1-TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48162:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48162">
        <property type="entry name" value="YALI0A06930P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1018" mass="117701" checksum="CE6F1AFCC60AD688" modified="2015-04-29" version="1" fragment="single">MDPTIYNDQYRLLICTTHGYAILSLESHLRNEHRDLSLQQRKEILSAHKGQVYARPDEINIPSPHQPPIDGLASPIPAFLCAAQFCGNVSSNIKTIEQHARHHHQWKKTTQQPVFWSQVQAQTFFVSRGLRKYFVVRSVSNSLPHTTSTSGPSSVRTAREIHGHEVRQSSSSNPTDVVPPAGDNARTIMQCLQEKRAVLDTVHETKMQRLEIGLLKQDRTGWYNRTKWQDHFHGRNLVYLAWATRMPEKNEPVLQEILNVFDRLAVWSADSVTTLDHESRRWLRSEQATVISARPFNRLQNADSEDRYFMYIRRFICYTCRVWDSEIQTRRRTHSTQSPQCTNDDETSNPQSSTTISNPMFNHIQTNIFSVRRSRTLYQEIDSDNTTNNNDNDDNDDDDDDDNNDDNDDNNDDNDDNNDDNDDNNDDNDDNNDDDDDNDNDDDDDNDDDDDNDDDDDNDDDDDNDDDDDNNNNNNDDDNNNNNHDDNNEQLSRSCTPNTERSNDDTTEDIMKDARELFPWTDNQFQATTNMVNSVCTFKDDEARGRQVTDSSKTEAVQLFLQQFIFHHVGGEPFKSGLIHFVAVLGIDEENRRLREAINFSYVVAGLVWSIRVLAVEILLPAHKRETQPDSHERRLKFQRYRREYLVDGSSTPMSELINLLAYGKYIALNTSNAGSMTWSRDGEIIYYHGLSIPLNSVRSMIISNIERAEELLWRELMWTSNLAQRFTVDLDQLEDDLPFTRRGWSFLKRERNQLANGYDWMAAKASTQRGKRRLLRVNGTWQLRGVRRWLQHTTYFLERLLFAMHSTYGPVSRGTEITAIRFRNGATADRNFFIIDGSACIITRYHKSQQLFDTPKVIPRFLPWRVGQLAVLYLVYIQPFRELLLSETQNLDPSDHLWHNDKGPWETDQLTRVIKRETALGLGHRFNTLDFRHIAIGVGRRVIGDQFGRGSKDEVGEIEEPEQEGEDPIELQSGRTEAMGASRYAVPADIIKHLSVRSLDTFRPLSEGWHRFLGLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJP9</accession>
    <name>A0A0D1ZJP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233228.1">
        <property type="nucleotide sequence ID" value="XM_016382525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZJP9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZJP9"/>
    <dbReference type="GeneID" id="27335282"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08199"/>
    <dbReference type="HOGENOM" id="CLU_021458_2_0_1"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF154">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="120"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="267"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="472" mass="51064" checksum="DE5C8B62E6EC2B99" modified="2015-04-29" version="1">MVATAKTINSLAGGARRLSKRLLASYLFDWILILGIAGLGGGFSKIHGARHDFSLQDPSISYPYHEDTVSVGVLIVVVLVAPGVITAAISLLFIPGPTASRRTPRALIWRRKIWEWNTAWMGLGLALASAFLITEGLKDLSGKPRPFMLSVCDPDTSPESIRRHQVGGLGSSLDSATPIVVTWHICRNTDKSQMRNAFASWPSGHSSFSWAGMLYLTFFICAKFAVQIPFLPPATSQTDGGSRRFISTFDEEEDYYPPYDHRQTSRVQRQQPHKPRGEDEAGPGPGAEEEHSSNSLHSAGTAGVSSSSSSSSSRLPPHPPRNEAAAPPIYLLIIAFVPVGVALFISVSRWFDYRHHGFDIISGSLIGIFTAWFGFRWYHLPIRGGSGWSWGARSRDRAFWLGVGRASYVGDEGWASAAAAAAAAHNNNHNHARRNGAGGVSDVEATAGSEHETVTGGGLPDRHDATERAALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZMN8</accession>
    <name>A0A0D1ZMN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234293.1">
        <property type="nucleotide sequence ID" value="XM_016381191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZMN8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZMN8"/>
    <dbReference type="GeneID" id="27333941"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06858"/>
    <dbReference type="HOGENOM" id="CLU_021115_0_0_1"/>
    <dbReference type="OrthoDB" id="5413703at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF1">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="210"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="730"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="746" mass="81923" checksum="5219E99015656C11" modified="2015-04-29" version="1">MSNSISSDGRSTRPRGFSNPSLDSHHVEAAKYHQAQQPINDAITSAFDNAGAASAASISPELLQQITSQITTNVLQHLKAINLSTTVPPAAVPGPTSQTDAASSAAGSPPLNRATVYTPPTPHRTSEDAGMSGASPEFPPPPPPPPQPPQSKEPALQGSSSPVENRSISPFSQASHQSHSDDNQERKSRPKGPKRVDTSGDATTLERVWGTLFDEQGRATARLGQFLRGIAVHLIENYEPKNSLVITPTKMQKYYESTRLSTEIYPWKIVFDDRTSSISRMFREIQAEHHLIQEKLSERPDLPGLTPRGFETWATILLKAHPDQEFERLAKTALDMPISNPDDKKERFPKELSRRLFPDHPDTETANRLQKAMATHCNVNLASRQGSAAGATDSNTKTPHQAQAGDDTQKAHPSPALEKQEPLPSASHPSPALSHASQEQRPPRQPYVSDASDIGDSPVENTEDIPTPQPIERERKPYVAAPGGGKTYESVSRPSEATETKASPGPPPPEVTIATSNSVPTTNRYSDNPRSSVPAVAIHQKPPPPPPPMDTETPRHYRSNGTYHQREQPRPGRHRSPSMGKESGSAPYVRKPEADSAYASSRHSYSGNDPYEDARRYKEYEAQRERLANDRYDAARMAAYDPRERERARPRENRPRMQSLSGYDGRPPPPQYSSSVPLTDEEYYRDPRHGGGAPSYNTPLSISTGFQPPPHPSTARDPNSIPRDPPSYGPYPSSAGYPPSSYREMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZN08</accession>
    <name>A0A0D1ZN08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234438.1">
        <property type="nucleotide sequence ID" value="XM_016381336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZN08"/>
    <dbReference type="STRING" id="91928.A0A0D1ZN08"/>
    <dbReference type="GeneID" id="27334087"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07004"/>
    <dbReference type="HOGENOM" id="CLU_013748_4_0_1"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="223"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="444"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="633" mass="67990" checksum="9A9F5FB08B87262E" modified="2015-04-29" version="1">MGSIAKKRKVDIAQQEYTTSFAFFEAIWEAGITHVFVNLGSDHPSIMEAIVKGQNEKEGNFPRIITCPNEMVALSMADGMARLTNKPQCVIVHVDVGTQGLAAAVHNASCGRAPVLIFAGLSPYTIEGEYRGSRTEYIHWIQDVPDQKQIVSQYCRYTGEIKAGRNVKQMVNRALQFATSDPQGPVYLCGAREPMEEDIEPYHLDEGVWQAVGAAALPQDAVEMIAKELVKAKEPLMIVGYTGRNPASVEANVALADKIPGLRVLDTGGSDMCFPTNHPAALGLRYGSEPAITTADFILVVDCDVPWIPTQCKPRADARIVHVDVDPLKQQMPVFYIPAIARFKADSATAFSQINDYLSSSSELTAALSDQSHVAAAKKRQAAYDARWGQFKELAKIPSDPVNAAIDPHVLGGQIRVAVPEDTIFAVEAVTLTGFIADQIAPVLPKSWINCGGGGLGWSGGGALGIKLATDFQHRDVVLGDGTGATKGKFVCQIVGDGTFMFSVPSSVYWISQRYDIPILTVVLNNKGWNAPRRSMLLVHPDGEGSKVDNKALNISFEPTPDYAGIAKAASCGKAWAGTVETVQELLDLLPQAVKAVRDEGRAAILEVKLGAADLSTKRSEVNGGTRVGTTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZNG6</accession>
    <name>A0A0D1ZNG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234598.1">
        <property type="nucleotide sequence ID" value="XM_016381496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZNG6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZNG6"/>
    <dbReference type="GeneID" id="27334247"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07164"/>
    <dbReference type="HOGENOM" id="CLU_010412_4_1_1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="133"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="21673" checksum="5792BB2F00FA8776" modified="2015-04-29" version="1">MSRSRSNSSTSNLSSKELPADSMAIQVSINGGKTIKLNVRPVHTISNVLEFLSASTNLPTDSQLMLDGKPLEPSTTVADLKLDESSTLQLSSPSRSTTPTQPAPATDVVTQKPSTSGTSTPTTSGTATPTKKKSNRPRCSKDGCKAPAQPIVGDCGFCQKRFCGKHRMLESHNCEGLEDARRADKDRNAAKLEGERTVMLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZP04</accession>
    <name>A0A0D1ZP04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234718.1">
        <property type="nucleotide sequence ID" value="XM_016381616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZP04"/>
    <dbReference type="STRING" id="91928.A0A0D1ZP04"/>
    <dbReference type="GeneID" id="27334369"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07286"/>
    <dbReference type="HOGENOM" id="CLU_432784_0_0_1"/>
    <dbReference type="OrthoDB" id="4137041at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="632" mass="71692" checksum="29ED8A0D5C290185" modified="2015-04-29" version="1">MDQGSTHNDNQSVSGVPTEAIPAAPSHETSSGERISTEINAADGSNLVGASSPAVYATYLEYVSSIEARWPEYRPFREFLQKQKDEGVVLQTQFVEVIDVSSAGKLSHKRYGEDFDYLPELERLSETLNEAPEDMKTRIIVVDNNFYSMPKAFMDVIGLAFDIEPLMFWTAIWSYKHNKDFVSLRSNHGVSVLGLPHLPLAPRFLHLGDGTCVQVIPQATIGGVQTNCFIIIVLTNTESSRRARAVLYDTNDRPHLHAQLEAWTFPETSFVRPSVLYRSALSRLTEPQLTSASHDPILFLPPLIHQHTAMFVTQTSFSEAKYQLQSDNNARREFDTLPNLWTELRDAIEQFELAIENCARFLKHYGRFEEEVFAGLRSNQDLALTRARRLEQQIRDYAQLEVGRLSLEESRKSIEASNTQIEEGKRVKLVTVLGFIFVPINLATSIFGMNIQELNYTGQRLWVFLVTTFAMVALVLFSWMASRKLLKMRDDYYDTQRNTGWEPEMESWATRLASIWWLLKKGRAIWMLRSKAFLALVTDGRVAMNGEWLTGYTDAPALYSRFPTSYIRDFRNIRNLDSAFPNTLSSAGTPGRRPTTTRFLSSFRMTTANNDHLRDGPTSSLAASTSVDIDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPX8</accession>
    <name>A0A0D1ZPX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235088.1">
        <property type="nucleotide sequence ID" value="XM_016381986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPX8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZPX8"/>
    <dbReference type="GeneID" id="27334740"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07657"/>
    <dbReference type="HOGENOM" id="CLU_019845_0_0_1"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF11">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="44"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="423" mass="46172" checksum="CFEAAD9A16DC6E8A" modified="2015-04-29" version="1">MLKKLLFYCKLMRFALSLGLERVGFLVLARIHRLTYKAVPNPKNVVVVGGSFAGFFLAKELADSLPTGYRVIVIEKHSHYYFTWNFPRVTVVEGHTQNAFVPYPDESLVQPAGVYSFRQGEVVDIGDGQVTLADGTIIPFEFLAIATGSNARYPAEMDADNKFDCIAFFEKQQQRIKAADHIVIVGAGAAGVEVAGDIMTTYKNKKVTLVHSRQQLLNKFGNELHNVAKKGLEDLGVELVLGDRVVAGLDSDGPAEIRLQSGKVLQADMLIRSTGQHPESTLVKKAFPSAISPSGNILVEKTLQIKGCPPNIFACGDVIDLPGPRLGRAATYQGMFVGDNIVRSIKGKPLKEYKPGMIDASIDLTLGVGNNVTYINDAGDEMTFPTKMPDVNLHAAQAWKVMYAKPFEDPGYTPKKVAELADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPZ1</accession>
    <name>A0A0D1ZPZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF788 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235098.1">
        <property type="nucleotide sequence ID" value="XM_016381996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPZ1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZPZ1"/>
    <dbReference type="GeneID" id="27334750"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07667"/>
    <dbReference type="HOGENOM" id="CLU_094308_1_0_1"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18980" checksum="0920EF0E7649D700" modified="2015-04-29" version="1">MANKHAKNLTVRNANRLKQTHLITAAINAVFLLLRFTLRRSLSLKRYILLSLPGLMIEFYLDRSAKPTYRQDGTMRGGEDLGAKGLTEFMWDVLYWTWINVILVIIFGNRAWWLYLIVPAYAIYAAVTTASGLKGMLGGMAGGGAEGASAPPSKRQAKMEKRGGQRVAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZS14</accession>
    <name>A0A0D1ZS14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RSE1/DDB1/CPSF1 first beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235783.1">
        <property type="nucleotide sequence ID" value="XM_016379956.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1ZS14"/>
    <dbReference type="GeneID" id="27332698"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05615"/>
    <dbReference type="HOGENOM" id="CLU_003539_0_0_1"/>
    <dbReference type="OrthoDB" id="20774at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="2">
        <location>
            <begin position="28"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1294" mass="144430" checksum="7F1811B8F6AD81CD" modified="2015-04-29" version="1">MSFPPSLEWNDRRRLGILSRTLNSTSCIRWILPARIRSPSKEDVVFVGATFIQLYEFIETGQLVNTTAKLDIGTQITDAKVISADVEVIPILDAILKQERDQENYSIGGQPINHGDPAQILVIVTVDNELIFACAREDNSGDVRFVFAKRPFLRGAGLPSSQCRYVAVEPKSRALAVASPSGYVGIFKLRKVDHIQREIEKWNPLEHGSFRPSDEQRFIQIRGDVMMITFLPSPESDPNRVVLLLLVWGGSEEKSTRQYMYSWDTRSPLQTIKPIPSSGRVLAEEEIPSMLIPSARPYSFIMVMKTGLSYYENVHTSDTKRIHCPFGQQAAGSLEWVQWAKPSRHNEYKEKRDDFVLLREDGLLQYFQIEKASSSKINLNWTIGRLGLKADTAFCMLAGPPGKGGDIFIVGGSMTDGGVFHVSARGTPECIQLLESICPLRGMVLGPSSANQLTDTWPREDPDRLFACCSRGSDQGVLLEIGYGVEAQVGWTVPYPDAALIDRLWTLELPDRNELLVLASQPTQSSMVSFELDTQELSFTNSESHPGFDFDHPTLMAAVVGGNSILQVTTQSISVVPTAVEASLSEFVRMKCELREAAFFEDGRLFVTARQATEGYEICLTSILDSVDGYGVILKEGTSTLLRDIPTSLCCFEIQGRRLVLVGSDEGRLHWYIVQEDTSLRKVFDRTADQFHYKLPGKCAVSSLAALKRCDGDPVLLLCGLRYGLLICLDFRCQDQHFDVFYSGIHRLGATSIRIFEEHMSPGRSGASSALVLCGSATSRVTLHRNASMVDYTMSSLYVTDRSDPSAQYTVTSLHRIPKLSSPCQDPGGLVVCATEDELLFCSLVAQEQTVTRRTSADGIPRHVLYSEYLEKFVVAFEKTHLLTGAPRPKDLQNIPSSRMGSGMKTSLPPRKIQQVGLHVIDPSLKASSDGRLSVIVTEETNESVNALIHWAPTDGEHHYEWFVLALEQKEAGFPRCSGRVVCVNAKNLSKGIPDTNPKVAFRSPEQPVTAICAYKMSSLLIAAGREIHLHHLDFASRKWKTLSKHRLPSAAKSISCQGSLIFIATAKHSLFVLIERSNKLFEHKSDNEARATKNVVPFDNSSAIFSAWNGGTTDIMAFGGFHQDGEEPYPLFQANLPLLIDHLLLRPHSVYLRNKYSSHRHRFYASASDGTLFHLTVIQYDEWKLLHFLEQASYMTTRSIKPVPIRARDGDGDEVTVRPPVVRLKDMHVRGDRLLLMIEEGPYNLRKILKGSMLEEFNALAECALGPKENYVESVAVWVRKLLHHPSNEWVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTU3</accession>
    <name>A0A0D1ZTU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06258</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236423.1">
        <property type="nucleotide sequence ID" value="XM_016380596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZTU3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZTU3"/>
    <dbReference type="GeneID" id="27333341"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06258"/>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000024">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="89"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="617" mass="67415" checksum="AA7AEF7A45937812" modified="2015-04-29" version="1">MSARYVSMVELIASLHDSCAPYVSLFALGTLSAVIVLVTGRFFVTPREDEIRYTIPVPEQLRAGYPEQCKVEEQAQQEDIIRAGKIYPSCPADGRPLGTPIQPATPSIIDAAISEAARAQVEWAHTTFSQRRRVLRTLLRYVLDHQDEIVAACCLDSGKTKIDACFGEILVTVEKLQWTIKHGEQALRPSRRPTNLLMCYKSNTVVYEPLGVVAACVSWNYAFHNFISPIISALFAGNAIIVKPSEQTCWSTFYFTDVVRGALQACGHSGDLVQTVICLPEVADHLTSHPGLSHITFIGSRDIAHKVCSSAARALTPVTVELGGKDPAVVLDDPQTARSIDDVVSILMRGVFQSAGQNCIGIERVIALPGVHDRLLEEVRHKISRLRLGSVLLDQHTPDIGAMISSRNFSMLENLITDAVERGATLHCGGKRYVHPKYPGGHYFEPTLLSGVTKDMPIAQKELFAPVFLLMRADSVDQVIEIANSTEYALGASVYGHNRGDVAKCVKEIKAGMVAVNDFGAYYACSMPFGGVRGSGYGRFGGDEGLRALCNVKSICEDALWARTLGIQTRIPPKLQYPVSEHGWDVCKGVVGTGYSLGLVEQGQSVFDLLRALLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZU35</accession>
    <name>A0A0D1ZU35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236523.1">
        <property type="nucleotide sequence ID" value="XM_016380696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZU35"/>
    <dbReference type="STRING" id="91928.A0A0D1ZU35"/>
    <dbReference type="GeneID" id="27333441"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06358"/>
    <dbReference type="HOGENOM" id="CLU_009834_3_0_1"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000113">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase family protein (AFU_orthologue AFUA_2G14850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27253" checksum="4910B3F0876372AE" modified="2015-04-29" version="1">MAPRFENLFIESPASAPGVHIVTLNKPPENRLNVAFAQTIINALRYIERDLMKPDSPGAVIISSFSDKFWCTGLELDESDSNVYANSDGFYPLLATLVDYPYPTVALITGHTFGGACPFMLSCDYRIMNSKRGFISMPPVNLGLHFDGIGALPRLKLHPQVARKMLLEAHKWTGEAALRDGIVDELSPPEKMRQRAIEFASTVAPRATMGVYGLLRTELWGEALDKFKAISYVHRKRIGTAAKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZUT1</accession>
    <name>A0A0D1ZUT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236703.1">
        <property type="nucleotide sequence ID" value="XM_016380876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZUT1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZUT1"/>
    <dbReference type="GeneID" id="27333625"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06542"/>
    <dbReference type="HOGENOM" id="CLU_043857_3_2_1"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="110" mass="12700" checksum="5C64C9E4E5B800CA" modified="2015-04-29" version="1">MGLTYNVYLNSAKIFGCKKCRTHLADFDDIISRNFRGQHGKAFLFSTVVNIKQAEAMERNMTTGRHIVRDIKCKQCDETVGWKYDKAYEASEKYKEGKYILESELLCTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZW98</accession>
    <name>A0A0D1ZW98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gentisate 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237168.1">
        <property type="nucleotide sequence ID" value="XM_016378491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZW98"/>
    <dbReference type="STRING" id="91928.A0A0D1ZW98"/>
    <dbReference type="GeneID" id="27331226"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04143"/>
    <dbReference type="HOGENOM" id="CLU_060572_1_0_1"/>
    <dbReference type="OrthoDB" id="2205143at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06992">
        <property type="entry name" value="cupin_GDO-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02216">
        <property type="entry name" value="cupin_GDO-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047183">
        <property type="entry name" value="GDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41517">
        <property type="entry name" value="1,2-DIOXYGENASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41517:SF1">
        <property type="entry name" value="CUPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="3">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-2" evidence="3">
        <location>
            <begin position="244"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="333" mass="37709" checksum="084110B861B58540" modified="2015-04-29" version="1">MATTTQTMTQGNGSKDPAEELVESALKVNTKPLWTQMARLNPPEPNPQCIPYIWRYDEVRPSLLKAGEIITEQQAERRVLMLVNPARDAPYTTDTLYAGLQLVMPNETAKAHRHTAFAMRFIIEGQGGFTAVHGRRITMQRGDVILTPTWNWHDHGKDGSGPMIWLDGLDLPNFRHFPVHFVEHYQKPRYPAEDVDSNDSPIVFPWKVMQQKLDEKEGDWASEDYLKKDGRPVSKILGGSAERLNAGCTSPAVRETASSVYHIVSGRGYSVVNGQRIQWKQGDTFCVPAWNKYQHTAEGDETVYLYRFHDKPMLTSLGFYRVEGSDVESLVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZXI9</accession>
    <name>A0A0D1ZXI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237608.1">
        <property type="nucleotide sequence ID" value="XM_016378931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZXI9"/>
    <dbReference type="GeneID" id="27331669"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04586"/>
    <dbReference type="HOGENOM" id="CLU_1722395_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="152" mass="16993" checksum="4FB59B844F82F0E7" modified="2015-04-29" version="1">MGRYTPCQNSNSVCFVLDGCSKCLSCTKKGVKYCDGTFSDKEFDSLTAQRNRLVEAAHQKDAELAQLITAVNKAHSERERLQREADLLLEKQKQMLVREAESLDTLDHVDPPEKASTTVFIGMDNKQLEEIFELSPGALLNFEGPISINRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYA4</accession>
    <name>A0A0D1ZYA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237843.1">
        <property type="nucleotide sequence ID" value="XM_016379166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYA4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZYA4"/>
    <dbReference type="GeneID" id="27331905"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04822"/>
    <dbReference type="HOGENOM" id="CLU_070871_3_1_1"/>
    <dbReference type="OrthoDB" id="2378324at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="55"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="230" mass="25196" checksum="478380D0B3C84C78" modified="2015-04-29" version="1">MCLESARAGAGETGSSSNTVDPAVRDALRVYVPRGSAMCADAFDLMMTALPLPIIHHSMRVFLFANWLARKEQSWWADTDALFVACICHDFGASHLHDGPQRFEVEGADVAADLLRKHHNSEQDAHEVWTAVALHTSAGIAERIAPLSRLVRLGVLIDFRPPTRQELGAVSFAEEIESKLPRLDIEMILGDAVVAQAVRNPKKAPPASWPGILYKAYLEHPERGGVNPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYX7</accession>
    <name>A0A0D1ZYX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238083.1">
        <property type="nucleotide sequence ID" value="XM_016379406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYX7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZYX7"/>
    <dbReference type="GeneID" id="27332145"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05062"/>
    <dbReference type="HOGENOM" id="CLU_000315_2_7_1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="407"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="818"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="992" mass="111005" checksum="813434FD15C76297" modified="2015-04-29" version="1">MLGLPQSAIPSTKSNGPCADRQTKCKLNVPPPPTTGYRASRERGEPPSKRRRTDETCRDDAFTSIKQDIGDFIWIDQDSQFHTAPVPPIEAVSAGTEVEDLLSILRFRDIGPQTVAPSFEDETLESIRRILADEDDALFSPATGQSNGCQSSESPTEEVCFGTVGPMPLALNPDKPPVLPTTLVKIHVLHNVRLDYDDGSVFLDDGSIIGQLDLRTAEILRELDSDARISIQVRCVLSRADTQGPKHRDGRLFSEVRATLAAIIYGPYLLYDQVGDFFEDCDVCLQDPPAGCARNVRYRNPHKLCGQDSDAPMTVDTALLARHDNTVNQELSTEHLDHLDFNGDLPEAEVPSALCTQLHKHQRQGLYFMKTRERGWCAENGLKDIWKTTEVCGVLMYWNTINDDVQEEPPEEFRGGLLLDDMGLGKTLTAISLVASDLDSGGTAGMLAWPRSFHPCSQDMRCTLVIVPPQLLQMWEEQLSTHLHPGRMRWTKHHGNHRLSQLSQINNFDVILTTYNTVASEAKTSSILFQARWRRIILDEAQEVRDPHTQTAKAVCALKADRRWGITGTPIQNHLTDFRALLQFLRAHPYHDQTVFARDITDIWQKTDPEAAMQRLMRIIASVSLRRSRKALVLPARIHQDTFLPFSPTELELYEPLEAQVMSILNQEIASTDTSTKRNALKGLNSLRLICNFGTLADMKHFRPYVTEAQEIFDNLLMAGDTSCCKCATNIASATGPSENCSGVPAFEVLTGEPAISHCEKYLCGNCNLEAQHNDGFSLGWCGHSPPCTVQTVRVTDPSSYLHRPSVDQLKLGDYPTKIRALINDLQAFPTAKSVVFSAWRMTLDLCDYALSLASIPFVRFDGTVSEPDRKDALSRFRTDPEIKVILITISCGAVGLDLTAANRAYILEPQWNPTVEDQAFARIHRMGQKRPVTTIRFLMKDSYEEEIVHVQKQKRDFADLLLSEKKGKNGKGVQKDMSLAYETVKRLIGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZF4</accession>
    <name>A0A0D1ZZF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_02349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238278.1">
        <property type="nucleotide sequence ID" value="XM_016376708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZF4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZF4"/>
    <dbReference type="GeneID" id="27329432"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02349"/>
    <dbReference type="HOGENOM" id="CLU_082632_0_1_1"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="8">
        <location>
            <begin position="96"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="210" mass="23223" checksum="37875E077FC2E5EF" modified="2015-04-29" version="1">MTAGIPTRLFLSAARLQCYAPETSAPKIACRALFSRKAHTCSSSVTRLRQHQAAVEHKKSQIRSHVRALEQGRRRFSTSPSTRHGHLDPPKPGEELHITIIDKDGEKHTFEVAEGDNLLDIAQANDIEMEGACGGSCACSTCHVIVESEDMYDKIPEASDDENDMLDLAFGLTETSRLGCQVQMTPELDGLVVKLPQMTRNMQASDFEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A358</accession>
    <name>A0A0D2A358_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239563.1">
        <property type="nucleotide sequence ID" value="XM_016377993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A358"/>
    <dbReference type="STRING" id="91928.A0A0D2A358"/>
    <dbReference type="GeneID" id="27330725"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03642"/>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="OrthoDB" id="5424793at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="59"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="252" mass="27063" checksum="315CB5C172AACDDC" modified="2015-04-29" version="1">MTSAAKATSLRVGMLLVPPVQLLDASPIDLFGMLSPEYLKACGLPQPLLDLAIPVSLHYISQSGPNSYASMTSDATLPVTDSLTSPGVQPGQLDVLLIPGPDPSLVPDAAVVDFIRAHQKKGTTDFLVICTGSFPAGYAGLLDGKKVTGPRGLVPKLKQKFPAANFVDRRWERDGRLWTSGGITNGLDLTAAYLHHKVQKELADLVCAMADVGDRSQDYESGKAGNTLWWIWLVLRSLVKSKPKSNQGKKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A9B8</accession>
    <name>A0A0D2A9B8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241588.1">
        <property type="nucleotide sequence ID" value="XM_016376312.1"/>
    </dbReference>
    <dbReference type="GeneID" id="27329035"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01952"/>
    <dbReference type="HOGENOM" id="CLU_003834_0_0_1"/>
    <dbReference type="OrthoDB" id="4158477at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253446" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="907"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="951"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1556" mass="149658" checksum="CD028AF34B007E33" modified="2015-04-29" version="1">MKSFGLLAVTASVALANRVIASPLTTIEPCPSATGHVYAPITVTSQYQPVSTCEPTTACVKGKCSTKYPFVTYPYVSTVVPCAWNGTTTQKTTVTEVAQPVRVSEYLETLTHITSVPLVHKFPLIDWFKMVPATTEEVTLYETVTRRAVAPYNAVGPLPIPGWEGSGLCEKCVNHDGTKSQLLEVTECRIGTELSGEQYANCVEWFETLIAQPPKSQTARGHCSSSGKIEHAGVYTWTFPQIAPPVTVTQPPVTVTVTVDGRPQVSVHRDVRVIPGKPWDAFITRSFSGPTVFNFNVYVTKVFIITLPHFTQPAQSTVTVTVPSGPHNGDPGHGGWWPVPSGHGSWSPSDGGNNAWEDWNPSTSSTTTSARVSTTSTSHGGWGTSSTATSSYSTTSSSASPSSSSAGSSSASSASASSSSASSSSATQSASSSSASSSSASSVSASSSSASQSSGSSSSATSSSTSSGANSSTSSSSETSSSASSSASSSASSSASSSAASSSASSSAGSSSGSSSSSSASSLPVTSSVTSTSSGSQSTASTTATSSASSTTSVGPSGTGFYLQISGRPISRLRARQNVVRYLGFDPQNRGIAVEDLSSAALVFRGTDGTSFLYNNRFLGTAVKAHSLVQSFLGLPSGFSIWDIVGSLAQLRGSAGFCFENGFVYAYTSDDVCDNPIDIIPTNPSTSTSTTVASSTSAVSTSSGASTSASSGAGTSSTSSGASTSSGASSSGASSTGASSSGASTTSGASSSGASSTGASSSGASTSSGTSSSGVSSSGTSTSESNSSSTSGSVGSSTSGSAVSTTTGSSVSSTSNSAGSSTTGSATAVSSSAGSSTSESSTLSSGGSSTGTTSGSGSSTSGQATSISGSSTSSTSGASGSTTSGSGGSSTSGASGSTTSGSGGSTTSGTAGSSTSGSQTPTTSGAGGSSTTSSGSVAAGSSTTGSGGSSTAGSSTAGSSTAGASSTGSSTAGSGGSSTASSSSGSQSSTSSGGGSSSTAGTSTVSSSTSGAGGSSSASSSASSTITSISTQSSSTTSSAPATTTSSGLTCNLNLNICLNSQLISANSVATLNCPLLGGILCTFNDLLSLIPQLLGLNSNILSVVVANNQLIGLSLTPQQVSAAFASGELSGVCDALGGPVSVVIRDPTCPNSPTSSTTSGPAGSTTSGSSGSSSTSGQATSSSGSNASSSSGQATSTSGSNGSSTSGGSGGSSTSGQATSTSGSNGPSTSGSTTSGGSGGSSTSGQASSTSGSSTSGTSTSGSDGSSTSGQATSTSGSNGSSTSGTSTSGGSGGSSTSGQATSTSGQASSTGSSTGSSSTPTTMVTSTTSFTSSLGGSSTTSSSTSTTTTPAVECNASVQFCAPIVVAWTVKSQTCPDVLGCTDAQMQAFANSFIGLPGIKSTAYANGVAYAFSVTAAELRRQLGLLGPINTLCTAVGIFNLAISDTTCPVTQLPAQQCNSDVTFCLGESVANAGITSGACSNGLLPCTTTQVITTARNSCTSSGTCLAYGRNGLTPIISSKTVAEVQEYVANYALSNTCLVGGTTITLSDASCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT88</accession>
    <name>A0A0D2AT88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_12024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847503">
        <property type="protein sequence ID" value="KIW09740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229956.1">
        <property type="nucleotide sequence ID" value="XM_016386331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT88"/>
    <dbReference type="STRING" id="91928.A0A0D2AT88"/>
    <dbReference type="GeneID" id="27339107"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12024"/>
    <dbReference type="HOGENOM" id="CLU_004286_7_2_1"/>
    <dbReference type="OrthoDB" id="4113884at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022198">
        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
        <property type="entry name" value="DUF3723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW09740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="459" mass="53228" checksum="5029390776BB8378" modified="2015-04-29" version="1">MRTSRARLEDAKFETERRRQHRGTARISLDVLKVQFEAHEQLDRNNVERLKGIYRREGCRPQLINNRILVEIDETSFDAALDLSGVAAADLFTPQRDDYPELRFPTGTEVICLHGKHRIQAGREFLSPRDKWWIADIYLGGLSTDVKRCLVEEYANESIPTDGMIFYKIRLYHFQRNLSFELRWWARLRGCRSRNLRALLKHPELTAAFDALLDVPGLWGGMLLTTLHKVLGLKSDDEILNYLEHVRRFWHDLVDGDPSALQKFDFRDVKALELRAPGVSSNDAEEIQAQIRAGRILRAFSEEERRYIFQRLCEFKYLIPSLHTFFRDITYWEACVGSVKHLMTISRRDTILSAFERGFTAINQRDDQVVIQVGETRFETLQGPHDAQVDLGYRQIVAFAMRHFVEIPREPMSDDVTVRPRAKADRATLRQFAELAIRVGFESPEALEKSCKGDAGYPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AY09</accession>
    <name>A0A0D2AY09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231541.1">
        <property type="nucleotide sequence ID" value="XM_016384939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AY09"/>
    <dbReference type="GeneID" id="27337708"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10625"/>
    <dbReference type="HOGENOM" id="CLU_007607_0_1_1"/>
    <dbReference type="OrthoDB" id="2534600at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="662" mass="73892" checksum="FDECA3A4EECFA2C9" modified="2015-04-29" version="1">MSEPGPPYPKRQRISQACKECRKRKSKCGGEYPSCLVCVSTNRVCTYDQNFRKRGLQAGYVRALEALLGTITRDSPDAERKIRASLRSPHLQGEVDEQRVTDIAVEAWRKSGLSKDIEQLLAASEDVFRTSSVALSPIAYSDAEDEQVDEATGLEEASQQTSLDLNGPPARHGQTQSLPDSPLPVETSNMVEFYFAQIQCWLPVLERRDVLRILHSETLPSALTISDKALRSCLWAIFAFVTAQGRFFSETHLTYERVLVGLCLQISEHEQQPELGHIQSRLITALLKIGLGQLNAAWTMIGATIRMLLGYQYRPPRYLHTLLVCIMLDNYLSSLLRRDSYFPPSNRIYLARVDDDSVEEWEYWNPPSPCTTAASDRRKGPMRSLSILNSMTQLVHHLAKINEQNVDDASLFEGLDALQTWKENLSGHHQISSSSPSNPPLLNLHLMWNFVMCSLLMKVSTLQDSIVELAEQCATSTVELLNIISRDMGMQTPLLQGYASQAWTCLHVVVRPEADSSACSAMARLLELKQSFRQYWQTRECGPANQPYEGAQNARYDPEVPGRSLSQLSGMASLSADVANPTASNRFVGTERHSTALVQPFAAAQTPETHFQGVPTNRAFPSEIEPGGDLENVNVPSADQFSDVNDFDAIFNQGPWIAPMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYM3</accession>
    <name>A0A0D2AYM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_10785</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231701.1">
        <property type="nucleotide sequence ID" value="XM_016385099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYM3"/>
    <dbReference type="STRING" id="91928.A0A0D2AYM3"/>
    <dbReference type="GeneID" id="27337868"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10785"/>
    <dbReference type="HOGENOM" id="CLU_000288_59_6_1"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000407">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="59"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="414"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="498"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="737"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="838"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="513"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="741"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="841"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW11485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="916" mass="102104" checksum="14959B901FC14628" modified="2015-04-29" version="1">MTSTIHDDELSISLPQHDKSKSKPTFPSVVSPPARQSPGQTPTAESPATARAMNRLHQYSFVRNIGEGSFGKVKLARHKVTGQEVAMKTINRRKLISRDMAGRIEREIQYLQLLRHPHIIKLYTVITTKTDIYMVLEYVPMELFDYIVKHGRLGEAKARKLFQQIICAVEYCHRHKIVHRDLKPENLLLDKNMNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVIGGKLYAGPEVDVWSCGVILYVFLVGRLPFDDEFIPALFKKIQAGTFHIPSQTPPGAVNLIKRCLQVHPVHRITIPEIRQDEWFKKDLPAYLVEPVEEFLDTGVDPSKAIDPRQLAPGKPLEVVERIHEQVIGKLGRTMGYAKEDVKDALSKDEPSAIKDAYLIVRENQLMVETSEYRAQNPELESFMASSPPGEPNFPILTASPMANGRKVGDDVKPLTPTPSDGHRTSRAPSETPSVQKEEEKPRISNVRVLNTSLPHVHEELLQIREKAKARGDDPDTILHPSQDPDKGDAESPIPEEIKDEQGNPIYRSKEEQEATSRALKPHSRSVTALSSLRESKPRPEGMTAIPSDEKDKRLPTSRSKPRKWQFGIRSRNAPYEAMKCLYAALKAQGAEWEVNPWLKAQGEGGEGEDEQDKGPAPPVELGPGERHSVLQQKYSFLKDDYYVPRDPWNIRARVLKKGMLMPGEAPSISAHSSAVSLPSEPQNQLKKHIEQLGYASEDVAKALGIKNGDVSGSSKSPHGSAQNTRPNTSVGDVAAQGQESFTGPGQHAVRTDSQSTLNRKVPSENIAVWVFIDIQLYTLETGTYVVDFKCDGYQNVIWHDVRKDKDRIKTSNSGSNVASPSNSRPTSGFSENHRTGSEQWDEGAPEGYWKPVSKRYRNVEKEISSPYPYLDVASDLVAQLWGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYX3</accession>
    <name>A0A0D2AYX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231866.1">
        <property type="nucleotide sequence ID" value="XM_016385264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYX3"/>
    <dbReference type="STRING" id="91928.A0A0D2AYX3"/>
    <dbReference type="GeneID" id="27338035"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10952"/>
    <dbReference type="HOGENOM" id="CLU_008442_1_0_1"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="735"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="775"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="843" mass="92601" checksum="A9C9612A7C1AF5A9" modified="2015-04-29" version="1">MEIDQVMVDAATASREKRRTGNGLTFALQALLNRHESYVTESQLEHERLTSYVNELEKERNSLQAANEKVVEENRELLNRLESANTSLKESDEHVKSLETLLRDCESEVRRLNGLSRQTEELELKMLDLERERIRLSEKVEESEEETRSTVQRWKESVLKVRQLEYEVQRIEWEAKQDRQRHEETIARLERERALERELGGAEGRLKGAAALQGLKGNGVTKNNVVSHFVRDILQDNANLQAGIAELRELLQNSNDEVQNLREQIMHHQPVDYDHMLEDPPISRPLSEQIDWAESCPKQVQQEVHVHHHYHAKLAARRDRTPTVRRTTRKRPMFGLGALPATPESSAPKTPLSGSSRYVSSPVVPLALHHPQPRYNRWSVQSAATVSSMLSSFPSSPRSYYEPSSSIFDRIEASEDSSRPTSPESAAGFAEPGYKSFKSRLLEDAVPHSLDEEDLEHAATSDDSSDAHDLRGLPPEEVPGTPAEEDEADEVRGSSQDLTPKPSQILVTAEHDDCEDAPGLSEIRIEFDGQDGTTSLPKQLEIRVEEHESVWAEEATKRDSRGIAPTQQETGFDDFASHMQMRHRRTNSHESLVSISGMDIHLAKRPATATSQASSLLKGNRAYFALSPSAARRLPAAQPSTTVTEFTALSSPRSISSNSIPSPNAYPSQSIEALSGLAGLPKISPAEQHHQSGGFGRLVGGWVKGRWGPAPTKLTSELKALNSNTSPGASSNHHQSQAKTSSSSPAPASSAATEGPLRSTLTSSSSSAPPPPPALAAASSLSSSLSTSSFSSPHPPPLFLGGRAPGINQKGMVPGFRPAKKPANPGVELKMVDVDGLKESLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZ01</accession>
    <name>A0A0D2AZ01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232144.1">
        <property type="nucleotide sequence ID" value="XM_016383521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZ01"/>
    <dbReference type="STRING" id="91928.A0A0D2AZ01"/>
    <dbReference type="GeneID" id="27336284"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09201"/>
    <dbReference type="HOGENOM" id="CLU_355661_0_0_1"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="774" mass="85013" checksum="918675F07DE18360" modified="2015-04-29" version="1">MASEELQACEHLRQELLQRGRPPASYSPLYVASCVNLMDVSSPDRVEQSIDACMDNLTRYFDSISLQRQLDDPGLSSFLAKITRESPFWRPRFGRSHGSQASEQHIAESIPPDCILEVARRIIARAWDESKREEVRSALRLVANCCADNNANRDVIVKRNGIQAMMTLAYHNRECDLLIPTMFNVCYQYNSPAIAEDGTPLPPLHETGEDKRAGAEEPTVNLAEQKLAVPVQPGQSTSSIEILLDMLPSAEHCIGLLADLVEMASHMALYGLHHIIPSPAATLTDGSEDLKSQDLKDRCSRLLDCLLTKGTQVIKNDRDAQVSICQATLNILSSPESHEAIIAADAGLWNFIHLPYVICEDELDADHEAVGAKETLAPFRKAFLKLVYQISSLDSYAEHSEPDSALIRDCIQALTARFQTDSRTDSGVRTGMDDEGGSLCCASMCVLIANSIISTGRAARLLESTGIATAVSTILRGTSDKELVLPAVDIATRLSLTPEGQEALCEQELLASVVRRLLDPNTAATDALGIEIQRQSVALARLLIKDRMASLSSLDPETETEGDGSITTDLLSLYQNTKDVRTRTEIGRFYIEILRTYFKTNQTSSSSSQFTESRLLHLISCPLQRPDITVTVADTIAFIITQPQPQGTAAPPTPSNSMLRTEAEAWFGLGLLSTIPNTRSEILTTLGGNGRELLKRLEGIARQQDSVAHTEISDVVPRSATAPDIDDPRYKNIRVLVVNLLRQDPNSDGDDKQKEVNERIREAAVIMDLDNVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZ51</accession>
    <name>A0A0D2AZ51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_09232</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232174.1">
        <property type="nucleotide sequence ID" value="XM_016383551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZ51"/>
    <dbReference type="STRING" id="91928.A0A0D2AZ51"/>
    <dbReference type="GeneID" id="27336315"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09232"/>
    <dbReference type="HOGENOM" id="CLU_016218_0_1_1"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW11958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="361" mass="38974" checksum="E0538D06DE3252C5" modified="2015-04-29" version="1">MLPDTTNSSSGTLAAFETPPTTPKPSQSPTTDFDIVAYYNDLVQNDPTITPPIAAIQALISLLAKTQLTTISETLSLLETHSQKLLASQRNPIPLSAGTELFQRYLVSSFQQRPSSLADSDFSTLRHHILTNSSLFVKRANEARLKIAHYALPLIKEESTIITYGYSRVVQTLLTHAAEAGRYFNVVYILPSAGLTDSISQCISQLKGLSIPTTTIPLSALTYALASLPTASSAPQLILGASAVLENGSVVTELGTHQIGLISKAVSVPLHIAVESYKFVRNFPLGFGPLDLARMGVKQDVLRFSTTTDSQADGQSASENQVVDVHEMVEITPPELIDALITENGILTPKAVSEELIKLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZM0</accession>
    <name>A0A0D2AZM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_09443</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232384.1">
        <property type="nucleotide sequence ID" value="XM_016383761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZM0"/>
    <dbReference type="STRING" id="91928.A0A0D2AZM0"/>
    <dbReference type="GeneID" id="27336526"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09443"/>
    <dbReference type="HOGENOM" id="CLU_076384_1_0_1"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="111"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="69"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW12168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="233" mass="26643" checksum="34836D30BA5D42BC" modified="2015-04-29" version="1">MDFGFVSSPSQSPSQSLFAAGPYFDSTSEGSSPDSPHQMSQIMFNSASMQYDMFRYPASSSNYYSTTQTTQIPVDYSNSDSLDQSDRRRRRRGSTSAPAKEKETIPNMHLRRRAQNRASQRAFRERKEKHVKGLERQLEDLHEKHQDLLQSYTRQADEVGRLTGRISELNAELNALRACQDQSFSEMLMPDKFDKFDAFSSTGILYHPSDSYFDKNAPDLNSEFALHSFEDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZY9</accession>
    <name>A0A0D2AZY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Intimal thickness related receptor IRP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_09259</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232201.1">
        <property type="nucleotide sequence ID" value="XM_016383578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZY9"/>
    <dbReference type="STRING" id="91928.A0A0D2AZY9"/>
    <dbReference type="GeneID" id="27336342"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09259"/>
    <dbReference type="HOGENOM" id="CLU_024065_1_0_1"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238732" description="Intimal thickness related receptor IRP domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="186"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW11985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="62048" checksum="34F41F87781153D8" modified="2015-04-29" version="1">MKRWAPSLGLLAYLATLVAGNEIKLNQDDANRQRCSGMYSRKSWGGSVEPFILVKYLPDHTEDDTDPISSLIIFEWTDEPLIGRMPAGSTEYRDLQTICNSDAVAQNLCEEKDIGSFILAPNATSLAQNPIFNEAIHLKDPKAINYPIRRTGYYCVSTYAFSDHEYDAVVEFRNSYGELPAAQIAKLPFYGGLTIVYAVLGVFWAFLYVQNRSDILPVQNYITFTIVFLIVEQLMTWGFYDYQNRHGNNTLNKMFMIVVSILNAGRNSLSFFLLLIVCMGFGVVKPSLGRTMIYVRILAAAHFIFGVIYAIASMAVTPESVGPLILFVILPLAGTLTAFYVWTLSSLNVTIKDLVDRRQKTKALMYKKLSWCILGSILVIFAFFFINSFALAGSGESDFVPRHWQTRWFVLDGWLNLVYLFDIAFIAYLWRPTANNRRFAMSDELAQDDDGFEIRSIADSLSDDEEAARKDHERDVSPPGGASSSLTDAVNVSPPRKASPAPALQNSSREPPNPPRVRESLDGETIFAVGDDNIEWSDGEEDSDDERKKLTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0D0</accession>
    <name>A0A0D2B0D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232629.1">
        <property type="nucleotide sequence ID" value="XM_016384006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0D0"/>
    <dbReference type="STRING" id="91928.A0A0D2B0D0"/>
    <dbReference type="GeneID" id="27336773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09690"/>
    <dbReference type="HOGENOM" id="CLU_079653_1_0_1"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="60"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="207" mass="23353" checksum="3196C53DEDB11AC5" modified="2015-04-29" version="1">MILRQPALLHCGSKPSTHCHRLLLQYKQRFILQSRTFFDSILSSALGPCPLRTVSHTKRLPYSPKVIFKAVSDVSGYPTFLPFTISSHVTSRDAAGYPTRARLKVGYEKLGLEEDWDSVVSCDPENGLVEARSSDKNSNGLFEVLNTKWHISQSGGGDDDHASVKLDVHVKFRNPIYDQLFSQVEEKVASTMISAFEKRVEELNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1H3</accession>
    <name>A0A0D2B1H3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232999.1">
        <property type="nucleotide sequence ID" value="XM_016382296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1H3"/>
    <dbReference type="STRING" id="91928.A0A0D2B1H3"/>
    <dbReference type="GeneID" id="27335053"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07970"/>
    <dbReference type="HOGENOM" id="CLU_015161_3_0_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="715" mass="80257" checksum="96401AA851BEA332" modified="2015-04-29" version="1">MDNPSAVRRPPKRTTEACEPCRRKKSRCPGEKPRCSHCARLGHNCSYSSGSRGRERGSQDSIAAPSRDQEGVRFSQSALFTDNATTARLNALEAGLAQIQNLLRHQSQDQHATHDLSLSESPANGGLSDSIGQSDSVRQERGDRDTPPLPPKPVVEAAVDVYMKFCNFQPLPLFSPQNWRDSFASWDVELLLSIVASALRFKDRWDLGINILDVDKRQYAAAAQKLVMHKVSYGPVDVSTIQCLCILSLNEFHDGYTARAGVFSSLAMELAQSGGLASEHYRSWPEDVYEERRRCFWSLNLLKNLHGNWSGSFSFLTGDYTPKFPKSPDLPIGPTTGSSQVTPDVNVSGTGIISYTVQMSALWSRTARYARRRSQRREIVCWEQNSEFSSITAQLMELDAKCPPEYRYRMARFRDQDPARLQQARHFWSPWLLTKFLYHTILCLLNHPLILSLRLRNFGADGVPEVFLRQTDDLIKNHTAWVVRLIDEVNATSFRLSDPYIAYCVSVVATIFLQQSYAEDAETRSSKQKNFDKCLNFIQNLGAYWPRVSEMASKVEQFANVVATSYHNSSSASIGSGRRVAIDLTHFWAIIESCFISELPTGSDPYFGPSLTLHRPTFNFSEVLDDTLLPTPTDFNASAQTVSGDTPVSLAMANNLVPNIDQASMRLANPVSQQQPQPLMDDCFSVLAHSYFAQGQDFANMDDWWYSTAVLQDPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B200</accession>
    <name>A0A0D2B200_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232846.1">
        <property type="nucleotide sequence ID" value="XM_016384223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B200"/>
    <dbReference type="STRING" id="91928.A0A0D2B200"/>
    <dbReference type="GeneID" id="27336991"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09908"/>
    <dbReference type="HOGENOM" id="CLU_007879_1_0_1"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000176">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="188"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="397"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="763"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="944" mass="104768" checksum="872A96A56320CE48" modified="2015-04-29" version="1">MLASPPAMNGDHGPMLDRNNIINVRDGESLYQICIKLRRRLSGVPGFRPYLEEMEKREEEGSDPVSSLWQCFRSGLPLLTIYNASNPEEGDLRVDTKRPERVGKEAAFLFIKACMQQMEIPAADTFTVTDLYSDNTTGFVKVTKLINRVLDILKLSGKLHPSTDSEGSRDGADSGLNVVDQAPKTLTRRQHILKELVETERQYVHHLQNLQSLKKEMEEVGALTGDAIHNIFLNLNNLLDFAQRFLIRIEQQNETPDEQQNWGRLFVHYKDPFRQYEPFIANQRRCETTCQKEWDRMVERATSPLAQQMLANPTILNGFLLKPFQRLTKYPLLLKDLQNQTPDPVLKSDLSDAIAIIQDVLMQADASIDKETRDDALQDLTERIDDWKQMNVATFGELLLLGTFNVMKDSGIRSDEKEYHIYLFSRILIMCKDVNANKPKNRLANSKPSLSRNGKPKMNLKGRIYFTNVTSVTSQSTPGNYALQISWKGEAAATETFIIKFKNDETLQKWHTMIETQRSSCMLESRNTGTTSDTQLLSLQGMSMENPYLNQEDDDDYSRLSGTTYGGTDATGYSEFTMSRNASSTSLRSRSATGGSGGSNPHLSAGRMRMPTGEMVGLSLNTRGLPVQSPQDSYGTSYFSPIERDSTPQSTVSARSSSQSAFAGYHRGATPVSGGGGRPEESYRNTAPAMPRNPNGQPSGNPYLVNGRRGPPPGPGQPRMRSASSPDVHPLVQQSRKYVSGEHAPSVPPIPAHVAKQMAPPARSQNNSPSNGPPSRQGTPQQYGLPQGPRPGMPNQNFSYDSSYAADPRRPSHAPSLSQGRTFSPPVSSPSSDGDGYIPSQLKAKVCFDENYVSMIIATNIQFRSLADRIDAKLARFTNHSIASGSVRLHYRDEDDDLILIDSDEAVHEALLDWRETHASNAANGQNAELLLYAHAVNREAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B258</accession>
    <name>A0A0D2B258_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232906.1">
        <property type="nucleotide sequence ID" value="XM_016384283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B258"/>
    <dbReference type="STRING" id="91928.A0A0D2B258"/>
    <dbReference type="GeneID" id="27337051"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09968"/>
    <dbReference type="HOGENOM" id="CLU_593163_0_0_1"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="461" mass="51742" checksum="81C5D62431D968A4" modified="2015-04-29" version="1">MSLVWVSHSGSGHRHPSARKIINSHAAQIGRDKHRERLAHTTEDAAVVRRKKKPRKGDDSEGNERNKVLPVWENTSPLSNQIGMSFLVPLASRVTEVLPHDGLVLGLSKAQTAMYGRELLGRAYQNEVFLLGLALYRLCALPLSKMPGSGTRNIIDTMRARFINLINSKLAYRAINDTLIHSICCATPVDEHLGLLEYSVAHLRGLEALVELRGGFSQVGSSYGPLADTLQSSVLHAITTTKLNIKRDGQPQTPIASEQSTPKDHIIELRCPIPGCLTPFYGENTELPEGFAELAAMDALSLPMCHIIRDFQRWLHNLPVDKADECASWRHQIPDNLSNLEKCIYLALSCLADDLSAVGVHVCMDLWRKPRPRAIQILHETTLWEVPKFADCLLWVATSVSLANDLVPYDIWEQLQDKILASRPDIVAIDDIVLILQGFFAPEKRLRIWRSRWEGRLLRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2D6</accession>
    <name>A0A0D2B2D6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233259.1">
        <property type="nucleotide sequence ID" value="XM_016382556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2D6"/>
    <dbReference type="STRING" id="91928.A0A0D2B2D6"/>
    <dbReference type="GeneID" id="27335313"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08230"/>
    <dbReference type="HOGENOM" id="CLU_019655_2_0_1"/>
    <dbReference type="OrthoDB" id="3344043at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="608" mass="65487" checksum="9DE9782038B3AA02" modified="2015-04-29" version="1">MYRKVNTGEVSRGFSKRPGTPSEVEDSHRRMSGRLVDIWTAFAIVTIPMLAFSAVLLGLVYRYRVTHSTTGDSRLRSPGTTDEAGVYYVNLSATVLIFISSWSSSVGPLLLGFLMTLASYPLTRHYWQDIQEQKPTLPTPFQFALSLKFLGGGGWGALYSWMQYLIGWKHQRQLQSRLLTESAFATVIVTILGIVVFLADTWLHITTSTVSFVDTNPATGTTNYSLSLVPGCLTTNNSGISHAAQCNLIQASTGTFLFDPAKSLTVLNNVSDSIEVHNNGPDERYAYLGVPQSGPVGNLDYTATTFGMRTECRAASRACNLNAAFGASTPFKCTDAFAGDLQVDTWLESYFPDSAMASNITGYGVGNPFYYGVGAGFQTVTNSELENSDEIVTPVHGGMALLLSCSIWIFDVEYDSINGTVTRFVATPSNDSVANIWQLPNQAAGVTTSNLQTAMLIAVSTATSIQDLADQYAVAYSKVALGVGAQSVELSPAMAAQERSSFLVTRLPMAPLFCLIAANLAFVVLGITLTYMALSTSSGGEVRDVQARLSIVGLVADRFEPGRSAGPATGIEELFKEHSGQSDSVVVAMERTADGGFAYREWTKITDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2J7</accession>
    <name>A0A0D2B2J7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MAP kinase kinase kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_08022</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233051.1">
        <property type="nucleotide sequence ID" value="XM_016382348.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2B2J7"/>
    <dbReference type="GeneID" id="27335105"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08022"/>
    <dbReference type="HOGENOM" id="CLU_001999_2_0_1"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1114"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="151"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1415"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1418"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW12835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1438" mass="160507" checksum="799C60AE1B7B4BAB" modified="2015-04-29" version="1">MHTQGHGLATSQPLYQPQALSASPTAAGETPVMLPLQATPTRPATNLASRTGARLSKGEEQRIEEGRLPPVMEHEEMPAMHRGSAASSSGSSDEDLSNTAASSSTVYGYPPSTYDASDNAGNFTTTPTSSVSAYTPSSGFSSLSSWNSYGTRPRGGSGSLNAASMDRTFSAVDPQTAAADLRGVRPTGPLRTPSNTYAPPRRPPQLSALNSKRMHSSSTMRPSRRDPNAQYKAQEKAYVQRMRQQPQDWLESDPRTPSIGYSTDDETDDESPSTEHPFDDPYDPETLMFLGNEDNLQPSEEELQNPQNRERLEWHSMLASVLKGDVVKQEKQRLIGTTEQKTRTEIGSEIWIGARAKYYGRPLLMQKKLIEESRKDLAPVIESIIAFEIKGETVVGKSPLEQVEEAVSKIEKCEWLYSSRRELETAQTRAASEAFQESCDAIVSWHNITQSINTELAVLQAWVGNPELDFSKQKRRSSHDGELSDESSFVDRILKEDGLKSLQGEKSMFKGIGQVINKAKSTLIENAEAFAARHLPPYIEELLTLINFPSRLIQEIIRMRLSYARKMKESAQQSVMIIDQMISQFQILMRLACLIKQQYLAISHPQPGWDLPPCIDESFDSVIVDALKFYFKMLNWKLGANKNTFREAEILEQEWGFSNEIGRQLEGGDIEVAEQFSSLTAKSLLRLTASFERELRSKPDESALDMEKRYKTILDSVRVRQRKLFRFSRILRQRFENATEFNLGMDAEQLQNFCESLTMSDHILLDVGPSSPKGVYFLASPSLWGRPKEIQSILGTSFHADDAPEDPSNPYILVIHPEDPIVWEGQRMDVDVLELPNDVRLGRLRLVADGSSLRLQGARMEFANAVGHDLDVVIEQRANLSRVNQELGKIKKTTFKLSNTIMESVEVIRSQNGGIASPELVQSCFAFATEFGKRSLTYMDANRRMMNNLKLTRLALDWISFICDDCDAADRKTFKWAVVALEFAMAMTRGRNVLDISEEDYRRIRVKVAGCMSVLISHFDIMGARSTLAAQQEKSRMEALSGINKRLDFNKLRNDEDCRQEMTELRVSQLCAIDQAREERGTKTSLGRVLEGSNEADRSLTFLSSSATNITMRWQQGQFVGGGTFGSVYAALNLDTGTLMAVKEIRLQDPQLIPTIVKQIGDEMGVLAVLDHPNIVSYYGIEVHRDKVYIFMEYCSGGSVAGLLEHGRIEDETVIMVYALQMLEGLAYLHSAHIVHRDIKPENVLLDHNGVIKYVDFGAAKIIARQGQTLMAAEPPKRMAAEGPHMANNGPAARQPQKTMTGTPMYMSPEVIRGDGPATSRFSGAADIWSLGCVILEMATGRRPWSTLDNEWAIMYNIAQGNPPQLPTEDQLSPSGIDFLKKCFERDPAKRSSAAELLQHSWIVEIRKLVVDEPDVQTPRSDSSGGVSLPSRHNSSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3I2</accession>
    <name>A0A0D2B3I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="4">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="4"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233431.1">
        <property type="nucleotide sequence ID" value="XM_016382728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3I2"/>
    <dbReference type="STRING" id="91928.A0A0D2B3I2"/>
    <dbReference type="GeneID" id="27335485"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08402"/>
    <dbReference type="HOGENOM" id="CLU_026244_0_0_1"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF3">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="8">
        <location>
            <begin position="113"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="8">
        <location>
            <begin position="180"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="322" mass="36869" checksum="1B2B0BA7CAA29CB0" modified="2015-04-29" version="1">MEPTKTLPASWYTSQNLYSLEQRAVFYKAWYLVGAVPRFAVDREVDYEFAGVTVTVHHDGEENFKVMRKSDALELDHHLTPTGLLFTTIDPSAPPFATWFPPSLLELLSGYNFRRLPHRRSIKYPGRFNWKTMVDGYQECLHCQYTHRTFSVKYPPTFYEVHNHGTYSRHIADPTKPDDGLFLYFYPVCTLNLYGGGMSSFRVCPGDKVGETRMEFDYYFDDGSEGGGMEGFEDYFKFVRKVALEDFELCEVAQSNLERGIYSQGVLNQSKESGVLHYQQLTRKMVVEKFKEEEAEKNALTPASSRASHGYASGQDDVSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5F4</accession>
    <name>A0A0D2B5F4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234349.1">
        <property type="nucleotide sequence ID" value="XM_016381247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5F4"/>
    <dbReference type="GeneID" id="27333997"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06914"/>
    <dbReference type="HOGENOM" id="CLU_072757_0_0_1"/>
    <dbReference type="OrthoDB" id="2818246at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01066">
        <property type="entry name" value="APP_MetAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF8">
        <property type="entry name" value="CYTOPLASMIC PEPTIDASE PEPQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="1">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="234" mass="26787" checksum="03B97A03E49F5A7C" modified="2015-04-29" version="1">MATDMSTLTEQQRANHLMQAQEMALQLFHEIERDLIRPGISEKTLSNEIHELGSRRHNVRTHWHKRVVRSGPNTLMPYAENPPDRIIQPDDILFVDLGPVFEAWEADFGRTFVLGDDPVKKKLRDSLDPVWNTVKARYHDNPEMTGGQLYEIACNEARNAGWEFGGQIAGHLVGSFPHERIPNDKIALYITEGNGESMSKTDAKGNKRHWILEVHLVDREREIGAFMEQLLTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5U1</accession>
    <name>A0A0D2B5U1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450 oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_06791</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234226.1">
        <property type="nucleotide sequence ID" value="XM_016381124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5U1"/>
    <dbReference type="STRING" id="91928.A0A0D2B5U1"/>
    <dbReference type="GeneID" id="27333874"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06791"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="57829" checksum="BCE980BBB0C88FAD" modified="2015-04-29" version="1">MDNIKSSSDSSLVAQALLFAKAHFFLVTFVAIVVRALYKKYASPLRDVPGPFLASCTRLWKVWSTWKGHTELDHIALHKKYGPIVRTSPNEISFGTCNAAKDIFAVGKGFHKTMFYSVFPPKHAPDIFTEVREWKHAQMKRYAVTPYSLAQMQKRSGPIESMIMLLMEHLGKYADDSRRVCNLGNLLHYFAFDVLGEVAFSKSFGFLDAEVDIEGSIKNIDDVQWYDGIVGQIPETDILFRNNPLRPYLPFWKPQPTTMTKIAVAELEKRKQKDGTYDSSGIDLLAELLRAHDGSPDKFSVQDVFSIAHGAVFAGSDSTASTMQSFFYHVLNKPEVYAKLQREVDEAQKSGQLSEIVTYAEAQKLDYFQACLKETFRIRPAVGLGIYRNVPPEGIMIDGRYYPKGTEVAVNGWVLHRDKSIFGEDVEEYRPERWFERDAKLMGGHLYNFGGGSHLCIGRNLALFEMNKVLIQILREFDIKLAHPGRPLEYHSTFFVVQEGLEAYLSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7N7</accession>
    <name>A0A0D2B7N7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger RING-type eukaryotic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235124.1">
        <property type="nucleotide sequence ID" value="XM_016382022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7N7"/>
    <dbReference type="STRING" id="91928.A0A0D2B7N7"/>
    <dbReference type="GeneID" id="27334776"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07693"/>
    <dbReference type="HOGENOM" id="CLU_053742_1_1_1"/>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger RING-type eukaryotic" evidence="6">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="432" mass="45858" checksum="4564E8B46BAF6BAC" modified="2015-04-29" version="1">MSHSKRNTSLAFFTAHESTTSGTTANSSGDGDDKNKSGTTTTTTTSTKVHLFCRECALNDLMAQRKEIKRLEREAELRKREMEDDLRRAEEESKREDLERFERGELDSAYYDDVFSGSGMRRKRIAEEMHSSAPNATTSTSTGTSNTSVRTSTGDGDGRDGSKKSKTNSTFPSVDTANGTRSGGNTKRQQSEASFWIPGSEFTSRHHGKDGATKTAAKLHPLCPASTPDHKHEYSLKSLTTVNFSFADDGDDGADGGGGGGGSGKRKDATKQPMCPSCKKMLTNTSRAMVGTAPGCGHVVCKSCADLLYRADTTSATTHATPSKEAATTALTAARSLDREQGTEKAKEQALILCYVCEADLSGPRGGGEGGGDGGSNDGTGKNDRHKHKGKDRNKDKAGDKVGTVVEISREGTGFAGGGTNMAKREGVAFQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9I2</accession>
    <name>A0A0D2B9I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">4-coumarate-CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05651</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235819.1">
        <property type="nucleotide sequence ID" value="XM_016379992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9I2"/>
    <dbReference type="STRING" id="91928.A0A0D2B9I2"/>
    <dbReference type="GeneID" id="27332734"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05651"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="445"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="60716" checksum="05F8EE41437BACE4" modified="2015-04-29" version="1">MPTNSSYPDIQIPQADLWGLMFEQPRDFPDTQVIYRSVDSSRQYTWADVKEAATAFGGGLRNLWDWQKGDVLNIYAPNDVDFAAVVYGVFYAGGIVSPANPAYSVDELSFQLTNSESRAIVTTIDFLQTALRAAKKSGIPQDRVILLGQGRDPSHRCKHWTNIRKTSGSSRYRRRKMDPDKDLAFLVYSSGTTGLPKGVMLSHRNVIADLLMIKSSMGKWYSSGQDKILGVLPFYHIYGLTGLVQQPLHRGIELVVMPAFNLEVFLKAIQDHKITFIYVAPPVIVRLARDKLVEQYDLSSVRMITSGAAPLTKELVDAVHKRLNIKINQAYGLSETSPMTHTQPWDEWYTSVGSVGKMFPSMKAKYISADGEELGPGQTGELWLSGPNIFKGYWKNEAATNDAITSDGFFKTGDVGFQDKNGNFYITDRVKELIKYKGFQVAPAELEGKLMDHPAINDVAVIGVNDDHQHTEVPRAYVVAAAGKTSEKDAAEIVKWLDGKVANHKRLRGGVRFIDEIPKSAAGKILRRVLKEKARQENSKPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBD4</accession>
    <name>A0A0D2BBD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236126.1">
        <property type="nucleotide sequence ID" value="XM_016380299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBD4"/>
    <dbReference type="STRING" id="91928.A0A0D2BBD4"/>
    <dbReference type="GeneID" id="27333043"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05960"/>
    <dbReference type="HOGENOM" id="CLU_071330_3_0_1"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000366">
        <property type="entry name" value="Protein FMP52, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="240" mass="25728" checksum="D12E6F273F2AC26B" modified="2015-04-29" version="1">MATALVVGCTGLIGSHILAILRTGTGPSKYSSVNTIARRSVPAAAESEPAVPVNEVLEKDTAKWGEHITALSPPPSTVFYALGTTRAAVGGFENQNKIEHEMNLQVAKAAKEAGTKTYVLISSTGASAASMFGYPRMKGEIEDVVTALEFEHTIIVRPGLIVGERDHNRGVLEHSLRSFANALGHLHHSLKDAWAQDADTIARATVAAAAEVEKGEVKDKVWILQQKDIVRLGKTEWKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBY5</accession>
    <name>A0A0D2BBY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236704.1">
        <property type="nucleotide sequence ID" value="XM_016380877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBY5"/>
    <dbReference type="STRING" id="91928.A0A0D2BBY5"/>
    <dbReference type="GeneID" id="27333626"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06543"/>
    <dbReference type="HOGENOM" id="CLU_019939_0_0_1"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000031">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="54"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="580"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="634" mass="70589" checksum="7DA4EF4521688B04" modified="2015-04-29" version="1">MASTLVKMALLLYGPLSRGSWPKKLAESRAAYDSLKSHFLRYIEHPNNLHSSSDPLADDDNSPWSTLRQDEIAREEIFQDVTRCMQDNYFFREPATQKRLLDILFIYSKLNPDVGYRQGMHELLAPILWVVQQDAVDPTSVPAAAQTMDDVDFMQEALGHKYVEHDSFSLFCAVMQNAKGSYETGDSKDASPIIARSKKIHDDILAAVDPELALHLHVVGILPQIYSIRWIRLLFGREFEFQEVLRVWDLLFAENLRPDIVDLTCVAMLLRSRWTLIDADYTTAITALTHYTLPHSSGGPRSLVRDAVFLERNRTIEAGATVIQHYTGRRPKQTDPQSSRSSSTARTVRSPQLRQSPSHSPGRFTSSQKQLESLFQEVTGGLQKRTEGWNVSKAVRSAVGEVRRNMNNYQTSHSRQTSRDTPDAGKSDSAQFLQQRLNELQERNHLLSKMLEDAVDSLRTVKLTTKEGVDEAEHNLNISLAKIQFVSVYLADPEIPIPKGESTADVEVDHQLDEKTATAAPAAQATALTGNLVRPKNHEAGKVAAEVGSGLQPAPARPSLMDSSFSFMLGENRHRSSFVSSVAALPEQERGNDLKSGQKMAAEDEKRQQDGSRKGSAVDDGGFTLAKIQGGRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDB3</accession>
    <name>A0A0D2BDB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha 1,6-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237154.1">
        <property type="nucleotide sequence ID" value="XM_016378477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDB3"/>
    <dbReference type="STRING" id="91928.A0A0D2BDB3"/>
    <dbReference type="GeneID" id="27331211"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04128"/>
    <dbReference type="HOGENOM" id="CLU_022381_5_1_1"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW16938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42775" checksum="143D7333B4C3F0BE" modified="2015-04-29" version="1">MRKPSKAALGSRLNMTFSTNTRRIAAVAVALVILFLLLRPTSSSSFDSDLIHSTAQSADRPSRSYPPPKPGQKSTSEESAPRALVSKPLRERLRYHFPYDIESKFPAYVWQTWKEGPGSGKFEARLRPFEATWTTLHPWFVHEVVTDDAAVHLINYLYASIPDVVEAYEAMPLPVLKADFFRYLILLARGGIYSDIDTSALKSATEWLPESLDKSQIGLVVGIEADPDRPDWNEWYARRIQFCQWTIQSKPGHPVLRDIVATVTEDTLAMKKAGRLQVGKTPDKSIMEFTGPGVWTDALFSYFNNRDFFDFSSRTSNITYSDFFAITEHKKIGDVIVLPITSFSPGVGQMGAEGPDHPMAFVKHEFDGSWKPADERMNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BED4</accession>
    <name>A0A0D2BED4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycine cleavage system T protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_11864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229980.1">
        <property type="nucleotide sequence ID" value="XM_016386172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BED4"/>
    <dbReference type="STRING" id="91928.A0A0D2BED4"/>
    <dbReference type="GeneID" id="27338947"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11864"/>
    <dbReference type="HOGENOM" id="CLU_007884_10_0_1"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="318"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW09764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="455" mass="49161" checksum="ADAB34A715BFDA75" modified="2015-04-29" version="1">MPMPFNDVHRKLGAEAIPFSDDSLRAGYPHQSHSESHKWTRSHASLFDVSDMVQHTISGPLAEEFLMTVTPGGINKLAKHSSILSCLLSVEGGMVDDVVITRLGKASFYLVTNSRCHDSDLSFLRSQLSRFISSECATKKAIDWNVLENYSLLSIQGPLSSAILQSMIFSDGDGPEPDSSLSTLYFGHSRWLQLHLRMEGFTTPSLLVSRTGHTGEDGFEISIPPERGPGPALVTSIANAITSDPQACRSASLRVKDSLRLEAGLCLYGDDIDPATTPPQAGLSWMIPEDRRLDHSPAFNGHEVIVSQLSRPDTISAQRVGLVVEPGLAAREGAKIVDLDDPREVIGKVTCGGPSPSLGGVNIAMGIVRLGWNIIGIKIGIRVRGKTRVAEVVDMPFVENSLYLGGEGNAFMGGVGKLQSRENVRQTYDFVVGFQSLTPRLEVWGGRGGGTNREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEW3</accession>
    <name>A0A0D2BEW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04356</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237381.1">
        <property type="nucleotide sequence ID" value="XM_016378704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEW3"/>
    <dbReference type="STRING" id="91928.A0A0D2BEW3"/>
    <dbReference type="GeneID" id="27331439"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04356"/>
    <dbReference type="HOGENOM" id="CLU_012907_1_1_1"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="50"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="376" mass="40465" checksum="2917800B9A59E2F4" modified="2015-04-29" version="1">MAASRLLRPASRLLSQRTALPSSIRPAFRHAAPLSLPTIRGYASESNQTFTVRDALNEALAEELELDDKVFVMGEEVAQYNGAYKVTKGLLDRFGPKRVIDTPITESGFCGLAVGAALAGLHPVCEFMTFNFAMQAIDQIINSAAKTHYMSGGIQPCPIVFRGPNGFAAGVAAQHSQDYSAWYGSIPGLKVVAPWSAEDAKGLLKAAIRDPNPVVVLENELLYGQAFPMSAEAQKNDFVLPFGKAKIERPGKDLTIVTLSRCVGQSLEAADVLKKKYGVEAEVINLRSIKPMDVEAIIKSVKKTGALMAVESGFPAFGVGAEILALAVEYGFDYLQAPPVRVTGAEVPTPYAQKLEELSFPQVDTITSYAAKLLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF23</accession>
    <name>A0A0D2BF23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237774.1">
        <property type="nucleotide sequence ID" value="XM_016379097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BF23"/>
    <dbReference type="GeneID" id="27331835"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04752"/>
    <dbReference type="HOGENOM" id="CLU_032992_1_1_1"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238978" description="Glycosyl transferase family 25 domain-containing protein" evidence="4">
        <location>
            <begin position="32"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="5">
        <location>
            <begin position="76"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="413" mass="46561" checksum="829F6191A3966F87" modified="2015-04-29" version="1">MSIVLLRFRYIVVVLLFTVLLLALCLRPPHAGTVGFPDAANSLARHVDASRRKFNASPYTKDRSIYRVQNETLGFQQVYMISLPHRTDKRDAFALQAAFSEISYTQMDGVDGHEVPEKALPHVGTWAIDRQVKTDKDGQTMEQSPNAIGCWRAHLNVAQRIVRERVATALVFEDDADWDVAFKQQLVQFARGSRVMLQTPDDKIPISPYGDGWDILWIGHCGTWVYPERRRRFFVIPNDPTVEPPQHRQNVKVPDMSYWEGPESDNKTRIVFKAGGGVCTASYAISQQGARKVLYYMSMVPFNKPVDWGLANLCETKAYNFRCISVFPQLVGVSRPQGNTSKWSDIGYGADNERKVENANSQHLVYSTRLNMENMLAGNAIFESQYPDSTPARMGIEEIGAAVGHVEVVDVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFS4</accession>
    <name>A0A0D2BFS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_11185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230440.1">
        <property type="nucleotide sequence ID" value="XM_016385496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFS4"/>
    <dbReference type="STRING" id="91928.A0A0D2BFS4"/>
    <dbReference type="GeneID" id="27338268"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11185"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW10224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="56234" checksum="E57BE40160142A55" modified="2015-04-29" version="1">MLPVTQLFGSSTALACYSFLLIFVALKLRQFLALRHIPGPFLASLTDFWFLYVMRLGDYKKQSLELHNKYGPLVRYGPNRVLFSDVEAISVVYGTKAPFQKARSYDVITPYINGKLVPSLITLRDEREVSAIKRHISHAFSNTAILDYEHHIDHTIQSLVKALQANGPELDLSDWLGYFAFDTLCRIGFSDDTEMTARGEDVGNTLLATRTRNHHWDRWLALPALESFWFKNRYLSGGMKADPLTNLAKQRFQARVDQGGAASTHHDLLDRYFQAQQKSPELFDNRRIVALIVTIINAGSETTGSSLAVAYYYILKHPHVYARIKQEIDEAGLSFPPQFRDVVKLKYVEACIKESMRVRATSQGPMERVVPPEGMTISGVFIAPGTVVAANKSASTLDPRIYDPSGKHPVHEYIPERWLGVDPSRTAQMDLASLPFSYGKRTCLGIHLAWCEMLKCLTAMFMRFDVDLKDRSFELEIEKGMIALVTPKGLPVIIKPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGJ4</accession>
    <name>A0A0D2BGJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238324.1">
        <property type="nucleotide sequence ID" value="XM_016376754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGJ4"/>
    <dbReference type="GeneID" id="27329478"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02395"/>
    <dbReference type="HOGENOM" id="CLU_1713020_0_0_1"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="13"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="171" mass="18345" checksum="F58BDE789F8D2647" modified="2015-04-29" version="1">MSELVSYHSPWSRLFLAARLLLVVEVVLLCAGGIVKGSSTAHAKVGEDLIKAGYVVLACSLSTLVFLGYIVWREGPARMVGGRKYMVAVTIATPLLTIRLVYGFLAVFNPTSSTWAGVEGSLAAYTLMSLLPEYISAVLLIGAGRLALRDVRAEKRSGRSVRLHERAPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHW6</accession>
    <name>A0A0D2BHW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238714.1">
        <property type="nucleotide sequence ID" value="XM_016377144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHW6"/>
    <dbReference type="STRING" id="91928.A0A0D2BHW6"/>
    <dbReference type="GeneID" id="27329869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02786"/>
    <dbReference type="HOGENOM" id="CLU_044656_2_2_1"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027924943" description="GPI-anchor transamidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="44767" checksum="1FE076C82E820861" modified="2015-04-29" version="1">MHLLHSLWAFLALASMACAAHTSNWAVLVSTSRFWFNYRHLANTLSLYRTVKRLGIPDSQILLLLPDDMACNPRNAFSGTVYSNADRRMDLYGENVEVDYRGYEVTVENFIRLLTDRWEEGVPASKRLQTDEGSNILIYMTGHGGSEFLKFQDSEEISSWDLADAFSQMREKKRYNEMLFMIDTCQANTLYRQFYAPGVIATGSSEEDESSYSHHADNDVGVAVIDRWTYYVLEFLETQVTGPTSDKTLGDLFDSYDVGKIHSNPGVRWDLFPGGEQAGRSRRVVDFFGNVQSIEVEGNRTSLESLKEDLEGLKRLVEEYETFATAQESNGTEMSDVVQRRNREATSSKKVPKTHQQRIGKLKLSENEQWTRQLGGATVLSGLAALWYFAPKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIF4</accession>
    <name>A0A0D2BIF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238596.1">
        <property type="nucleotide sequence ID" value="XM_016377026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIF4"/>
    <dbReference type="STRING" id="91928.A0A0D2BIF4"/>
    <dbReference type="GeneID" id="27329751"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02668"/>
    <dbReference type="HOGENOM" id="CLU_094690_0_0_1"/>
    <dbReference type="OrthoDB" id="5427091at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25388" checksum="F37940EEE6AC2CF8" modified="2015-04-29" version="1">MGEDYGTSSLPPHIGTLLNSITNTTTNTTSSSSSSSSSFSSSGDGDDLDIFLHCWIQPHCPACLSADNKYPCSWCATSQVCVPNTVYGYPFGILAPLKTDSLCPLGWRERWELRARPFSCRCSSMTFVSVVVAVLATLLSLQLMWLLITLGRRAGRRWRTRQKGWWRLRNWGRGPVWTMRRPPGRDDAAGTQSTQSQNENDGVGGDGDGNRTRTIPQAPRQDDETTPLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ72</accession>
    <name>A0A0D2BJ72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_10694</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231610.1">
        <property type="nucleotide sequence ID" value="XM_016385008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ72"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ72"/>
    <dbReference type="GeneID" id="27337777"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10694"/>
    <dbReference type="HOGENOM" id="CLU_007057_0_0_1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF66">
        <property type="entry name" value="HISKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="476"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="863"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW11394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="986" mass="108094" checksum="D06E1C03AD8E621C" modified="2015-04-29" version="1">METVQGSPALRKLEPHWNYGLIAASVAVSLLGAFTSTQMMCQARTARYFSGVLVWTLLGSLTFGFCSIWSLHFIAMLACELDVRIGLDVPLTIVSALLAVLFTFSALSFDLLQDRYIRLLVKKKKTKKRMKRTNPRGSKSDIQDNAELSDNEEHVSTEALLPPRLSEDQEPLDSLQELEQRGRTPHRPSRTDSGLGPLEQHFVGLDTTVRGSALHLDLEEDPHTPFRQPPKQQADFHYRDTSEGDTESLQRSSIDGDLSRRSSTTHSSDGSGLNLPAFMSFRMSRLPSSTATGLTGFAQLLVHGVKLKKICKGFLWSLAIDSMHYVGVLAMKISGGHFTLNPYIVVLSALISWVVCTIGCILIPQIEINLSQQLLFSCIAASGVAAMHFTGMWATTFWSQADPSPDRGYPPDLPVAVTSIAILTCMLANGLLAHSATIARNKLAEIVQTRKKLWAAIAQKENAEAAARARSEFIASASHEIRTPLHQLQGYSDLLSRTALNDESRLLLLAIQEATRSLSMITANVLDWSRLEKGEAVFRPTSLDLRKACESIVNILPSTDDDTITELMIVVAPKVPQSVFLDETYLQRILMNLLTNALKFTHSGYVILFVDCTDDKLVITVKDSGFGIPETFLPHLFEPFKQAQTRGAERGTGLGLAIIKHLLEKISGTISVQSTCSNIDGGGLTESGSTFTVTIPTSGLLAGAKPLPALGHKRQMAVYQKEGSRLSEGLKMAWAAYDVEVFPADPHSDISDDWGYIWADLDYIKDESELLGRLLQPRSQFVILPYGSQPLLDRTIGAAPPSHVIPIRRPLLWHRMVENIVSVVHLGRSCTDNKSVRFAPMVDMVENAPLGPATEQRALSGSTVLLVEDNKINLKLGVKMLQALGYNVMTANDGQDAVEKLVEHDLEIDLILMDQSMPRKDGVTALKEIRSMEQDGSLSRSRPLIMVTAVVGPDAASLCISSGADAFLPKPLSLQKLGLTLKKFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMA6</accession>
    <name>A0A0D2BMA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240264.1">
        <property type="nucleotide sequence ID" value="XM_016374988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMA6"/>
    <dbReference type="STRING" id="91928.A0A0D2BMA6"/>
    <dbReference type="GeneID" id="27327706"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00623"/>
    <dbReference type="HOGENOM" id="CLU_039522_1_0_1"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="248"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="391" mass="43086" checksum="DE12E063C01C2306" modified="2015-04-29" version="1">MSWLWRSDANSPASFEKALSKLSAQITDANLALDTTRTRARRAKALWTLYTTLTYLLYTLVVVLVLGPDAWFWYHYAGLVGAPVIIYTVRKLLTAFFDWRVNRQQSYLDHLQKQRESKIADLKKATKYDSTQELLQKYGGAPPSKSPSKKPQQGAKRQVNRPPERHPQRTGLPPPPTANIPGRNVQAPAGLPPQVGSPPASPTHVQMPLAVEMARSPVDMSSDVPGFAPNAFADPPPPTTAYETTHHWYDRILDVMLGEDETAAKNRLVLLCSNCRLVNGQAPPGVKTLEELGRWRCSTCGAWNGVESEGAKVVKEITAVSNLHDGEEWERVPAMSSDHEEPEEGQHEDSTSHEAVDGSHGATGRDAVDDNGISKRVTRSASKKPSLDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNH7</accession>
    <name>A0A0D2BNH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232905.1">
        <property type="nucleotide sequence ID" value="XM_016384282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNH7"/>
    <dbReference type="STRING" id="91928.A0A0D2BNH7"/>
    <dbReference type="GeneID" id="27337050"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09967"/>
    <dbReference type="HOGENOM" id="CLU_011226_6_1_1"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03057">
        <property type="entry name" value="GST_N_Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="89"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="214" mass="24288" checksum="2235E3084ADA47DE" modified="2015-04-29" version="1">MSAPNVPRLKLWYSPGACSFAPHALLLESGLSFQLILSQVGSFTDDFMSLNPKGRVPVLAMDEELVTEMPAILTAISQHVPDRHLLGKTPLETIRVYEWLNYLSGTVHGQGYGALWRLARYIEDPMLYAQVQQKGLETIKECYAYIEGKLIENKTTYLVGQSLTATDFFLFVIYRWGLRANINMKVEYLWMTAWADRLLEEKSVLGALKVHTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNX5</accession>
    <name>A0A0D2BNX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,3-dihydroxybenzoate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233035.1">
        <property type="nucleotide sequence ID" value="XM_016382332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNX5"/>
    <dbReference type="STRING" id="91928.A0A0D2BNX5"/>
    <dbReference type="GeneID" id="27335089"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08006"/>
    <dbReference type="HOGENOM" id="CLU_039329_5_2_1"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000043">
        <property type="entry name" value="Amidohydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="64"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="334" mass="38289" checksum="04368238E16648FE" modified="2015-04-29" version="1">MLGKITLEDHFNLPDFAEKAKWWAGLFAVDADKHVREISDVGKIRLGYADEYGVGYHILSYTAPGIQDIADPKKAIELARQVNDYIYEQIKDKPDRFGSFATLSMHDPAEAAAELRRCVEQYGFKGALVNDIQIGPDGESLIFYDKPEWDVFWQTCVELDVPFYLHPKQPTGVVYEKLWADRKWLVGPPLSFAQGVSLHLLGMVVNGVFDRNPKLQIIIGHLGEHIPFDLWRINHWFEDVKKPLGLKETCKKTIRDYFRDNIWITTSGHFSTSTLKYCIEELGGADRIMFATDYPFECYKDACTWFDGLKLDEGQKEAIGRQNALRLFKLKDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP66</accession>
    <name>A0A0D2BP66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240934.1">
        <property type="nucleotide sequence ID" value="XM_016375658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP66"/>
    <dbReference type="STRING" id="91928.A0A0D2BP66"/>
    <dbReference type="GeneID" id="27328378"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01295"/>
    <dbReference type="HOGENOM" id="CLU_045148_2_1_1"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="364" mass="40436" checksum="79C7785E91EF9446" modified="2015-04-29" version="1">MSGNSAASSPSSPGLGITGGYEGDSLAVKVIIAFFLSLAMYNVIELQILVFGTFNKFKGLYFWSLVISGLGIIPYSLGFLFKYFSILKGGGKWFSIFLLSIGWYPMVTGQAVVLWSRLHLIVTGEKGDKILKWTKWMIIVNAICLHVPTTVLTFGSNGDTDTQTFVRGYNVMEKVQMCGFFLQEVILSTIYIIETVRILHTSVQENTRRLMYQLMAINILIIIMDIGLLGLECASLYILETTIKPVFYSVKLKLEFAILGRLVKFVGGPRRGSDRRPSITIPGSAEKRNSSALSRVDENDVSDFVDLTKIRTDVTRASHPRNRSTSLHRNGEDFDIDLEIARLEHVDTLPSQIPIPNGHANGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPB2</accession>
    <name>A0A0D2BPB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240989.1">
        <property type="nucleotide sequence ID" value="XM_016375713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPB2"/>
    <dbReference type="STRING" id="91928.A0A0D2BPB2"/>
    <dbReference type="GeneID" id="27328434"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01351"/>
    <dbReference type="HOGENOM" id="CLU_438040_0_0_1"/>
    <dbReference type="OrthoDB" id="5414836at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122:SF1">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250010" evidence="2">
        <location>
            <begin position="21"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="574" mass="60180" checksum="527B908A57410309" modified="2015-04-29" version="1">MHLSLGLLVTSSLAVAATSAEPSATIIETPRPGPPPPVLQNTTLINETIIEICPPPPTVFFNVTDYVPITETATTTVTAVTTATYIDTTTTPITIFQTIISTTVVTATATVTTTETETDTETSTTTTTTLSISPTTDTATITNTATDTTTDTLTETTSTTNTATKIISEYLTTEQVTSITLCPTRIANPTYTANEPYPTDWTWGCPPGWLCRPQRQNCNFEAGIPSDNFYCAPNECIPAETLPAYLPTWDADIYGNSTPITNPGLNVQAIDNFFNMEPLQFGLSYQIFVVDEVFTLTSTFLEQPTPTIAARQAQTSVPGACYPWCNNCLLEAQSSGKSPKLCLPGSAFETSLNQCEQCINVHRGDDTGFVQIAPQFQQFLDYCDQYATVVVTTSATVTTSNAGGTTVSIVSSILSTTVTPIASASTSTSSGALGSSTTVVATTATPTPPSAASPSPPPITTTESTTATTTYTETTVASTDWPQITIIMPVGDNSTTTVYGSTLPSGSATLVLPKAVISSQVTSDATGSAASGTSSAPPSTFTGAGVAMKFSSGWNARMTILLDLVVPTLLLLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPF4</accession>
    <name>A0A0D2BPF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pirin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_00975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240616.1">
        <property type="nucleotide sequence ID" value="XM_016375340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPF4"/>
    <dbReference type="STRING" id="91928.A0A0D2BPF4"/>
    <dbReference type="GeneID" id="27328058"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00975"/>
    <dbReference type="HOGENOM" id="CLU_045717_0_1_1"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="175"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW20400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33328" checksum="B23D6D3C14B5F153" modified="2015-04-29" version="1">MTTPRAIKFSLLAREQSEGAGATVRRSIGTPKLRNFTPFLMLDHFRSPPGSGFPDHPHRGQETITYILQGAVDHEDFAGNKGRIEAGDLQFMTAGRGIMHAEMPAQDVEMNDGIQLWVDLPANLKSTEPRYRDLRAGEIPVATADDGKVEVKVISGKSQGVDSIKDLAYTPVWFLDVTVQPGGKITQELPPEWNAFAYTLDGVVTFGNGKKDAGETVVPYHNVVFERDGGDVVTAHVEEGAAEPAHFIIVAGLPLDQPIVQYGPFVTTSKEAVYQAMMDFQTSSNGFERAANWESEIGKTLGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ60</accession>
    <name>A0A0D2BQ60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233480.1">
        <property type="nucleotide sequence ID" value="XM_016382777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ60"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ60"/>
    <dbReference type="GeneID" id="27335534"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08451"/>
    <dbReference type="HOGENOM" id="CLU_072626_0_1_1"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF28">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="115"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="25796" checksum="C9592FA3D90B35AE" modified="2015-04-29" version="1">MSDMEALVEALSEYSTYVPPRQLYAGLESHMRSCDVSDALGKLGVPHSGFLAGPTLWSPERQCGKTKLVGPAYTVQYVPVSDETSPKCPSHYIDSVPSGAVIVISAPATINAVYGSLMSTRAQASGAVGTVVDGRIRDLQDHRDLGYPVFAREIGTAAPYGVARVSGFNVPIDFNKEGGTVSVHPGDYIVGDLNGVVCIPAKLADQVVKLIAPQVEADSKIARDLRNGVPFTEASKKHRAKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQG1</accession>
    <name>A0A0D2BQG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heme oxygenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241424.1">
        <property type="nucleotide sequence ID" value="XM_016376148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQG1"/>
    <dbReference type="STRING" id="91928.A0A0D2BQG1"/>
    <dbReference type="GeneID" id="27328871"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01788"/>
    <dbReference type="HOGENOM" id="CLU_038284_0_0_1"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33033" checksum="AF88289046AC120D" modified="2015-04-29" version="1">MDISPIAASRPALPVELHAATREQHHALNTAILGRLPLCLPPCVNSPLLYTQGMIVFGQIYFAFEGFLEKSLTSALFDVRLRGIYQRMHFRELTRSSRLRDDIELLRSRLDHRVAVDLSRLSEQAQVFASRITSYLSSQPYALLAYTWAMYLALFNGGQWIRRQLVSAGPDFWGTGELPLSFWDFGVDDGGDVQQETLKVRFKTAFADASALLTEVESSEVIDGARDLFVTCLQMVEFLDQAVVERTSSESRSPGFGYPSPTSTFVTAWGYITSSLALLKTTTQVVWSSRVEVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQH9</accession>
    <name>A0A0D2BQH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_08577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233605.1">
        <property type="nucleotide sequence ID" value="XM_016382902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQH9"/>
    <dbReference type="STRING" id="91928.A0A0D2BQH9"/>
    <dbReference type="GeneID" id="27335660"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08577"/>
    <dbReference type="HOGENOM" id="CLU_006462_1_2_1"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056300">
        <property type="entry name" value="SusG-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23915">
        <property type="entry name" value="SusG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="30"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW13389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="577" mass="66063" checksum="969C219CA315E299" modified="2015-04-29" version="1">MTQQCPVGFETDHDSLLQARKWWKESIIYQIYPRSYQDSNGDGIGDLNGITAKLDYIKGLGANLIWICPMYKSPKSDYGYDISDYYTVSEEYGTNEDLSTLVATAKNKDIGILLDLVINHTSDEHEWFQKALQDPSSKYRDYYFFKQGINGQPPNNWRSYFGGSAWEPVPSEQNMFYLHAFGTRMPDLNWENAELREALYTMINWWLEKGIAGFRIDAIMNIKKTMIEGTVEPDGNDGLVAIHKYIINQPGIKDLLQGLKDNTFTKHNIMTLAEAAVPDDQLEDFIGPNGLFNMSFDFRAADIDIPESGEWYRPTDWTINQLRDTLLNVQTSVQRKGWGATYFENHDQNRSINKYFRQHKEDISDVTKKLLATILLGFRGTPVVYEGEEIGMENIQLTSIDQYEDVNTHGQYKAAIAAGVDAEQALRLVSYRSRDNSRTPMQWDSSDNGGFTTGKPWFPVNSNYKTVNVAQAIKNKDSVYHHYRRLIELRTGHHYKDVLVYGKTVPKYTDIDNVMAYERVLGNQSVLFFANFQNKALELDNGAFRGKVLSNNYADISVEEDRINLSPYQALVVDTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BS52</accession>
    <name>A0A0D2BS52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_01845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241481.1">
        <property type="nucleotide sequence ID" value="XM_016376205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BS52"/>
    <dbReference type="STRING" id="91928.A0A0D2BS52"/>
    <dbReference type="GeneID" id="27328928"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01845"/>
    <dbReference type="HOGENOM" id="CLU_012538_0_1_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF3">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="656"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW21265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="715" mass="80774" checksum="C2EF64B532019215" modified="2015-04-29" version="1">MTNNSSHICPVCAKSYKRPEHLRRHFFSHRPDRPHRCHQCESAFQRSDVLKRHLKTCERVSQPQRRRSSVCTVDERPNNAAVGEFSTATELVTPPLQPSLINNVGEGILSQQPLPPPSTWYPVADSASEFAFSDGFSDVPWADILSVDLGNSQPPAASQDVRKQRFQFLNDFTSHYGLAQSFGCGTLAQRSHMLSGCWECQSTGRDDAFGTFLQSSPSDLVPFNTLPYLEHDTWDGNDCGVARIASSWISDPYAAVTNDITSLIRKVVVVKSRRSIVTHEWTPLLHHMSLRFFSPPQIRKYLSLYWGFWHPQVNFIHKPTFDVLASKSILVAAMTLIGACLSPDAEDRDNAKMWLNCVEELVFTDDDLLEDSDFSVEYGSKHFNSSRNRLQALQAAYLVVLFQNWEGVDKSRRRVRRERFSTIVSVARDIGLHTAQQLDYSQLSANDFVWTEFVLREELIRVFLWIFLIDTAFVIFNNLPPRLVIKEMKMHMACTEATFQASTARTCWDQIQRDLELKRESGNIKALCSAVELLCKDSGRIPQDQLLALADLGPLNLFSMTSALHSLIFHYQNSLGCHGQLIPVRNAIHNWREAWLIYQAQSLMKPRYSTVGEGEVPCRDFWRQIGFVRHAAEYWLLASFMLEKISTAAEASAKQDETVAGGSGGGGDASTAPDAETSTPTVEPMLGKYDETSMQQVHDLLADFQNMYITTEIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSC4</accession>
    <name>A0A0D2BSC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241551.1">
        <property type="nucleotide sequence ID" value="XM_016376275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSC4"/>
    <dbReference type="GeneID" id="27328998"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01915"/>
    <dbReference type="HOGENOM" id="CLU_1896221_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239296" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="13683" checksum="39CCC0F6658AD3D1" modified="2015-04-29" version="1">MFEHTTKSGVVLVLLSLTSQVQSSPIALPAPQAVTAQISPITPPRAGSTGDVPGNFGIVVMDVSISTSRATGSAGAARTPSRPPTVLDRLAVSRSVLFFFVDVVVFLHGGTVGTACPLITGLMPDEHDAAAQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSI7</accession>
    <name>A0A0D2BSI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_07006</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234440.1">
        <property type="nucleotide sequence ID" value="XM_016381338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSI7"/>
    <dbReference type="STRING" id="91928.A0A0D2BSI7"/>
    <dbReference type="GeneID" id="27334089"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07006"/>
    <dbReference type="HOGENOM" id="CLU_006204_0_1_1"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="685"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="243"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="743"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="751"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="688"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="690"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="706"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="712"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="715"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="729"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="732"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="687"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW14224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="767" mass="81555" checksum="DB53637723815B87" modified="2015-04-29" version="1">MTTTATSNIRGGPSTRRVNPGRHSKALGSSLRHNSLVSGGGLLPSSSSVLAASNTGPGFIGSEAPEIYPAITHFADAISALPREFRRHHSLLKEVDAKAWAHEESLQTVLQHCVADTRAHSYEVALAGHEQNGLTTGDDLASVSEIHSVAGGSTDAASLVSARTADSTSLQRRHLYHSLRQNLIAIMQTMDEKNHVITNANEEVTKQIRRLDTIWPHISQEISEEARLGSLTHWAYTETNSVAAKKPAEPVPRGRAGESEVAGRSQSRRDDVQAKRQRGVLNVDSDFDESRPAQRKVHGSKKRTVETAAEVPPALGASSVTATKRRKPDKPTGGAPMERSISSAMSSRAPAMSRENSQQDNMKKRKASQPTSVARKRLNAQGNDSPKLVSSPLAGTTVKEAAYKRSPALSAARPAGRGRQNSAQSFDAPRGRQSSVASSKNGNQNVTVNTSELNKVAALTGKTADEGKSSFKETKTDDGDRLLKDEPVANGTSSEETSLRGALLIERSASRQEARSDLEDVSVSAKASPRLTPALRLDEVKHERVGRGRASKTSTPVASTFADAEESESASANGGKSDTGSKSRRPARPRVKDHGLHDSLSPKGLPMKRFHKKNGSLSVYASGPGSATGRTKDENGTPLSATPSVSDKDRDVDKGGESLGLGLGLGVENEDDDAADGDGEHEDEERYCYCQGVSYGEMVACDKADCPRQWFHLECIGLKSVPKSAKWYCDECKEVLAKKGKLTNGGGSGNGATSTSASNGAGNELAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSK0</accession>
    <name>A0A0D2BSK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241621.1">
        <property type="nucleotide sequence ID" value="XM_016376345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSK0"/>
    <dbReference type="GeneID" id="27329068"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01985"/>
    <dbReference type="HOGENOM" id="CLU_150823_0_1_1"/>
    <dbReference type="OrthoDB" id="2157103at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="107" mass="11475" checksum="C2BA3E4EC9ED7D3B" modified="2015-04-29" version="1">MSLLRITTSPQTFACGPTGITIARLAHSTAVSSSVKQNPSKPAEPDKSNKPPETPKESHKSMAQADEEMRNIMEGLSGDGGASGAELEDGKPVAMKRSVRENMFRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BTU5</accession>
    <name>A0A0D2BTU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234895.1">
        <property type="nucleotide sequence ID" value="XM_016381793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BTU5"/>
    <dbReference type="GeneID" id="27334546"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07463"/>
    <dbReference type="HOGENOM" id="CLU_2003666_0_0_1"/>
    <dbReference type="OrthoDB" id="4126038at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="131" mass="15119" checksum="5CBAE11645017558" modified="2015-04-29" version="1">MAPVTIKLRDPPEEVRQKLGLSKQQFDNFKTYALNVHREYCARHPHSSWANQETVWSAIPEVEKQQVVRMLKTMCTDRRLFPPGFDGTLVQSGCEQRLHQCRRTWQQTGRTRGRGARAGAEDDDPQEGPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BUP9</accession>
    <name>A0A0D2BUP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07741</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235170.1">
        <property type="nucleotide sequence ID" value="XM_016382068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BUP9"/>
    <dbReference type="STRING" id="91928.A0A0D2BUP9"/>
    <dbReference type="GeneID" id="27334824"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07741"/>
    <dbReference type="HOGENOM" id="CLU_031468_2_0_1"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000609">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF40">
        <property type="entry name" value="REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14497)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="190"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="323" mass="35644" checksum="81B6999009E83297" modified="2015-04-29" version="1">MAKQVNVMLYGLGAIGSFYAFILNQSKRVRLTVVARSNYEAVKNNGLHISSMNHGNHLFRPAKVLRTPAEAGETFDYVVCVHKAIDQSSVPKQLEPAIDEKKTCIVIVQNGVGNEDPFREAFPSSPILSCVTWVGAKQDQPGFVTHMATENTKIGIFPSDKLEAATEQSRLQEFASLLRDGGTPFDIEDNIQVQRWEKVVWNCAWNSLTTLTMLDTHSWLASSADSTPMTRTLMREVIDVARKCGVPLQYDLVDTLIDRILAMPPIGSSMQTDCKMGRPMEIDVILGTPVRKAKELGVPVPTLEVLYTLLQAIDGRLKANAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWH3</accession>
    <name>A0A0D2BWH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235835.1">
        <property type="nucleotide sequence ID" value="XM_016380008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWH3"/>
    <dbReference type="STRING" id="91928.A0A0D2BWH3"/>
    <dbReference type="GeneID" id="27332750"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05667"/>
    <dbReference type="HOGENOM" id="CLU_063935_1_1_1"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="24434" checksum="6F845D27C04FDA5B" modified="2015-04-29" version="1">MSVWDAFTGRRKQQAEPHQTESAPTPSAGGYAPASFDPSYTTDVSTLLGAASLPDASKLHPLAGLNQQTLDYLSLDESTLSDLPGARSFLPSRGWSDDLCYGTGTVYLAALTTGGAWGLIEGLNRTPASAPPKLRLNSVLNSITRRGPFLGNSAGVVAMVYNGFNSTLGYYRGKHDAANSIVAGALSGAIFKSTRGLKPMLISSGIVASIAGAWALTRKVLFEPPQESQNANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWQ0</accession>
    <name>A0A0D2BWQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="3 8">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_05769</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235935.1">
        <property type="nucleotide sequence ID" value="XM_016380108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWQ0"/>
    <dbReference type="STRING" id="91928.A0A0D2BWQ0"/>
    <dbReference type="GeneID" id="27332852"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05769"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_1"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="11">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="103"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="10">
        <location>
            <begin position="550"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW15719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="670" mass="74116" checksum="4BEF462641643BCE" modified="2015-04-29" version="1">MSEGKVQPPKAPVVAEAHEVDTFHVPKPFFTKGPGKAHLKDLDEYWSMYKESIEQPDKFWGKMARDLLSWQQDFQTVHTGSLQNGDNAWFLEGRLNASFNCVDRHAIKNPDKPAIIYEADEPNEGRTLTYGELLREVSRVAYTLKQMGVKKGDTVALYLPMIPEAVISFLAVTRIGAVHSVVFAGFSSGSLADRIIDANSKVVITTDEGKRGGKLIGTKKIVDEALKKCPDVSHVLVYKRTGADVPWTKGRDFWWHEEVEKYPNYIAPESMNSEDPLFLLYTSGSTGKPKGVMHSTAGYLLGAAATGKYVFDIHDDDVFFCGGDVGWITGHTYVVYAPLLLGVATVVFEGTPAYPNFSRYWDVIDKHNVTQFYVAPTALRLLKRAGDEHIHHKLHKLRVLGSVGEPIAAEVWKWYFESVGKEEAHIVDTYWQTETGSHVITPLAGVTPTKPGSASLPFFGIEPAIIDPVSGAEIEGNDVEGVLAFKQAWPSMARTVWGAHKRYMDTYLNVYKGYYFTGDGAGRDHEGYYWIRGRVDDVVNVSGHRLSTAEIEAALIEHDGVAEAAVVGINDELTGQAVNAFVSLKDGVDPGEATRKDLILQVRKQIGPFAAPKAIFIVDDLPKTRSGKIMRRILRKILSGEEDSLGDTSTLSDPSVVDRIIETVKSSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BX36</accession>
    <name>A0A0D2BX36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Karyogamy protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236080.1">
        <property type="nucleotide sequence ID" value="XM_016380253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BX36"/>
    <dbReference type="STRING" id="91928.A0A0D2BX36"/>
    <dbReference type="GeneID" id="27332997"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05914"/>
    <dbReference type="HOGENOM" id="CLU_005577_2_1_1"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="765"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="802"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="851" mass="93680" checksum="B20263317D6A9610" modified="2015-04-29" version="1">MVETQSDLDLHQLLVPTPTNDVPPSHHSSSASSGPNSDAGSFVIPDSLSRSNSVFSFSRASFSSQLASLTAINLPQAESLAATVTTLPTARKAVKALTGAAEQIQSWIKKALKVLDNLDAEEDVEWAAAAGRLGLDETDKIVNTFEDLINVYVISIEELQTRPDIADAKTEELQGVVEQMEVTLEGWGNVRKQLKKIHGQVELAMEWEELWAKVLGDVGAEMDSLSQLVFEMEEKRHAAYTTQTQAGPSQNIDLNELESFIDEPTQKKSTPNSRFSLPPFESSPLGSPIIENPQDDSNLLALFARMQPLRASLDFLPMRMSMFQTRAEKIFPNACRELDDKRDRLERNWIELSKEADNLRRELSEDRWVIVFRNAGRQAQKMCESVERSILKVQEAIHENYQAINPAALAKRIESFEAKKMHYGPAINRVLAIIQKGLKDRLTVNGEILRLHKDLSSRMRDLTDTMEDLETLLEPFNTRQNSKLRESISSIVSADRSLSSTTFAGTPGSSPPSSIDLPPQSSQSSTPKYGLNGYTKSRTPSSSRPPPHALANRRSSLLPQTRRPTTPLSHTGSSTIKRGVSPMPGPPSVYRQGVYNPPVGPAPQSRQTPPSNKPRWSAVVKSDDSTLAPSYRSSTTTTPLTTRRYTPRSISSTTAVPLRSPLSREASASPSALPTMARRESQQFKSFAERVADPSPARSSGLMDPVPYHRGRNPSAPAVGTIRSPSSLAVHSQHRPTMSAVQPARPPSSLNRSYGRSTGVPSRSISHDPRTESQAENREPTLPSVDYYERFNDVEEEDQDQITEPNSSPLSKRTITRPSSVLAMSGKGKRMSLLPVPKGSGRQSSLGSRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0Z5</accession>
    <name>A0A0D2C0Z5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose 1-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237570.1">
        <property type="nucleotide sequence ID" value="XM_016378893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0Z5"/>
    <dbReference type="STRING" id="91928.A0A0D2C0Z5"/>
    <dbReference type="GeneID" id="27331629"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04546"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="29787" checksum="EA1D66ED9D67CC40" modified="2015-04-29" version="1">MAESRQGRLAGKNAIITGAAGGIGLETTILFAREGASVLMADISEPALERALAKVKELVPNAPRLETIKCDVSKESDVAAAVDSQDAHGGIDIMFNNAGIMHAKDDDAVNTPEAIWDLTQAINVKGVWYGSKHAVLSMRRHKKAAGSVINTASFVALMGAATPQLAYTASKGAVLAMTRELAIVHARENIRFNSLCPGPLNTPLLQDWLGDDVHKRHRREVHFPSGRFGEAVEQAQAVLFLASDESSFVNATEFVVDGGLSRAYVTAEGPAPPAPLNNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3I0</accession>
    <name>A0A0D2C3I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_02477</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238405.1">
        <property type="nucleotide sequence ID" value="XM_016376835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3I0"/>
    <dbReference type="STRING" id="91928.A0A0D2C3I0"/>
    <dbReference type="GeneID" id="27329560"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02477"/>
    <dbReference type="HOGENOM" id="CLU_049768_1_4_1"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="13">
        <location>
            <begin position="87"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW18189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="265" mass="29808" checksum="606FAC830E53CC92" modified="2015-04-29" version="1">MSTSWLGLVDGASNDEVEQPVKPHEPARDVRDEAPMTPPASLSRPASPYTLHPPIDFDGLSWPCIGTRERREQTPEEAQARLDKLAGAVKTIFECIGEDPEREGIRDTPQRYAKALMYFTKGYEENVQELVNGAVFHEDHDELVIVKDIEVFSLCEHHMVPFTGKMHIGYIPNKRVLGLSKFARLAEMFSRRLQVQERLTKQVALAIAEVLKPQGVAVVMESNHLCMVMRGVEKTQSSTTTSCMLGAMRSSAKTREEFLTLLNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C562</accession>
    <name>A0A0D2C562_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238955.1">
        <property type="nucleotide sequence ID" value="XM_016377385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C562"/>
    <dbReference type="STRING" id="91928.A0A0D2C562"/>
    <dbReference type="GeneID" id="27330111"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03028"/>
    <dbReference type="HOGENOM" id="CLU_010813_0_1_1"/>
    <dbReference type="OrthoDB" id="4116913at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="226"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="547" mass="61385" checksum="E1C1CE72BAE4402D" modified="2015-04-29" version="1">MPHASSQSTRPPQASPIEPSIESPQGRSPASSPAGLIYCAGYRLGDIGLFHGIPFLSRDGQQWIGIRSDDESGAESETSPPWHNQRQPWPTFSSFINPSHLDVTKLLPLPLVERFLANYFKSPFSEAFPIVDRVLFPKIIERAYTQQGSSPESATSKACIFAFLAFSSLNGYDADPGLPPLHEQQCITAAQLLIPDLFTARPSAEVVDALLMFAIYNFGCGNVHAVDLMLSAVVRFLFMLGAHLYPGEEMDSLPPEALSLEKRKALHLRDDFWICYVLDKEITFRTGRPPIINDSSCDLTFPKYYWKQSDRNFKGVYRLPGDLRLSTIKSNAYERLYSPQALRKADAEILKDIRELDEMLENWRLSLPLERRPTLSAAQPPNKSTETNGDGSFDFDISTFLLKLEYHHCMTTIHQASSRCTNWVYNHRIDDGLSSSLDLALASSRAMLTYFSSVHDHLFPNIFWVAVFYPLSAILTLFCNIMLSPASASAASDLKILEWNIDFMSERNSKDFLLSVAQLTHLDRLKQSCVELLRLARTSVLQSQGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C7V6</accession>
    <name>A0A0D2C7V6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239875.1">
        <property type="nucleotide sequence ID" value="XM_016374599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C7V6"/>
    <dbReference type="STRING" id="91928.A0A0D2C7V6"/>
    <dbReference type="GeneID" id="27327316"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00233"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58965" checksum="6104B4E0B89D7B03" modified="2015-04-29" version="1">MEAIKLFLSSPTRLLVVIMVIVFSLYNVVKRSLKKYPYPLPPSPPSEPLFGHFRSLPLENAHLKHMAYAKQYNSDVVYFNVLGNHMIVLNSQKAANEILDKRGANYQDRPSFVLFDVMGWGLTLTFMPYGPRFKLHRSALQTGFTKSAIVNYRPIQEDEARQAVARILKSPENWDHSLRRFASGIVLRIGFGVTVKSDDDPYIKIAKDANLATAEGGNPGTALVDYLPSFRYVPEFLNFSQTLRHARRWKWAIKNLHDIPFAAIKKEFDQGTANPSFAYSLLSKYSENEKQGVPNSFTMNDIQGASGSVFIAGSNTTFATTTVALLNLMLNPRVFQKARAEIDRVVGRDRLPSLADRPKLPYIDYIVEETTRWRPLSPIGIPHKSLQDDIYNEMFIPKGTYVYYNTYAMSRDPSVYKDAETFMPERFIPQEEGGAGEPYLVGPFGFGRRICVGRHLAQASVWIFIATLIATVDVSKPLDASGRPIEQPIKFSTGLSSHPGKFDVVFKPRSSDAESLLSDAVGDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CB22</accession>
    <name>A0A0D2CB22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="3 8">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_01347</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="3 8"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240985.1">
        <property type="nucleotide sequence ID" value="XM_016375709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CB22"/>
    <dbReference type="STRING" id="91928.A0A0D2CB22"/>
    <dbReference type="GeneID" id="27328430"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01347"/>
    <dbReference type="HOGENOM" id="CLU_022882_2_0_1"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000056">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="11">
        <location>
            <begin position="159"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="12">
        <location>
            <begin position="327"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW20769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="543" mass="61892" checksum="BF9FE30A3E336BD3" modified="2015-04-29" version="1">MADSSPPNASPEQREEQLESESETEEQPQGAAEPTASKPKKKKKRSKRSKIVSAITGNKSSEPAEASSSQPTAKLSNDHIKQLLDMNPTLKGELAGLPTEKAAEVLRNMDMQQLLSGMSLNGKNQKDMASYKFWQTQPVPRFDERPDSERPDGPIKEVIPELVPKTAAPLPEGYEWVELDMTNDAEVKEVYNLLTLHYVEDDHAMFRFNYSAVFLDWALKSPDWKKSWHIGVRAKGPSRLLVATIFGIPIKLRIRESILDVVEINYMCVHKKLRSRRLAPVLIKEVTRRCHLEGVYQAIYTGGVILPTPVGSCRYFHRSLDWLKLYEVGFSPLPPNSTAARMIARNQLPTSTSTPGWRVMQEKDIDPVWDLLTRYLKRFDLVQEFNKAEIEHWFYNKHKPDDQVVWSFVVEKDGKITDFASFYSLESSVIGAMSQKHDRIRAAYLYYYATDQAFNPKEKGLKSRLQEIVQDLLIEAKKAKFDVFNALTLHDNPLFLTDLKFGAGDGQLHHYLYNWRTKPINGGINERNQADESKRGGIGIVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CC59</accession>
    <name>A0A0D2CC59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_01633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241270.1">
        <property type="nucleotide sequence ID" value="XM_016375994.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2CC59"/>
    <dbReference type="GeneID" id="27328716"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01633"/>
    <dbReference type="HOGENOM" id="CLU_001832_4_0_1"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23827">
        <property type="entry name" value="RWD_YLR419W-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000868">
        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="342"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="7">
        <location>
            <begin position="402"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="585"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="812"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW21054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1340" mass="148597" checksum="4AD5C77096F39B10" modified="2015-04-29" version="1">MAPKKGSASAKGNASKNSTPAVPDSEHIVFTNSQKDKKKKDVSQPEGPPRPDARKVIGGQSWTGKLPVNLLSEHCQRQKWNKPEYQGRQVTSGTNGEKMHRSWVVLSKTDPKTGVVTRLPPFQLPAGSAHLTDQPTALEARHFAAAYALFRVSSMKNLSMALPPTYRDLWRGDFQRLKQEDVKEDRAWKYDADPFAAEAKRQEIKAKLEKRKQEQQAAPPKVETLTLVNSNATGTTVKGWDRAHRIDLGQNSRMGLESIIRTKTTWNTAGTIITKAERASIASDLAKSGFLPSHVQEALDYCGSREEVLEWLLIHLPEDSLPSWSFPPGYHAGVSLVTSDISTDTKVKRLSEAGYPSQLCLQALRDNDGSEALAMEALQFSLASHKSDMPINIPSDADLWTEEMAALEAIYAERFTASDESQCSVQVTLSNSLQATLLFRLPKHGYPIHSPPITVLKDTKLPSYVRLSIIKRAVEFAQANLLGDQMIFNLIQWLEESIPKVVESPGKLVDLEIARPSLTMQRLSDNPSDATYKRKKRVERTHQRDVRSNSSILESWAAKQDLEEQKKMLASRQKLPAWAKKTAIVEEISRHQVTLITGETGSGKSTQSIQFVLDDAIQNMKGSSANLICTQPRRVAALSLSDRVSAERCTIEGDEVGYIIRGDSKISSTTKIIFQTTGVLLRRLQSAENVKEALENVSHIFVDEVHERSLDTDFLLALLRDALPALPHLKVVLMSATLNADTFANYFGGGQNVGRVHVEGRTYPVEDFYLDDVIHLIQHERNRAVSVDSEGPLSLEVGRAIQNLGMGINYQLIADLVQHIDKDLANNRGGVLVFVPGTMEIDRCQRALNELPGIHSLPLHASLAPAEQRLVFKRPPSGKRKVVVATNVAETSITIEDIVAVIDTGKVKETNYDPSSNIVRLEEAWASQAACKQRRGRAGRVQAGKCYKLFTRNVEQNMAAAASPEMHRTPLEQLCLSVKATGSERNVEDFLARTISPPDSRAVATAMRTLRRMGALENERLTGLGTYLAMIPADLRCAKLLIYGVLFECLDPCLTIAAILTTKSPFVSPRDKRAEAREARLSFSSPSDGDLILDCAAYDQWKEYSSTTTRYRDVQDWCSSRFLSPQTLRDIDSTRRQLRDSLVETGLLPVDYSRHFTGLNKRKGNTMLLRALIAGALNPQLARIQMPDKKYIASVSGAKELDAEAKAIKYFNEENGRVFVHPSSALFDAQNFSGAAAFVSYFTKMETSKTFIRDLTPLNAYALLLFGGPIEIDTSGQGLVVDGWLKLKGWARIGVLVSRLRLLLDDELTRRIDAPGPSNQDDGGLFDLVRHLVELNGQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCD4</accession>
    <name>A0A0D2CCD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 14 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241370.1">
        <property type="nucleotide sequence ID" value="XM_016376094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCD4"/>
    <dbReference type="STRING" id="91928.A0A0D2CCD4"/>
    <dbReference type="GeneID" id="27328817"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01734"/>
    <dbReference type="HOGENOM" id="CLU_164170_0_0_1"/>
    <dbReference type="OrthoDB" id="2141050at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10991" checksum="60356790C91633C5" modified="2015-04-29" version="1">MVHKILFWAGFGIATRFVQLGIEMRPFFQRGGLWVYPLFAGIGGSFGYWLKGVEDRQVKLLQQRKEMIIEKRRRRAEREAAEVSQSETAGVLASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y427</accession>
    <name>A0A0D1Y427_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_12054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847504">
        <property type="protein sequence ID" value="KIW09711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229927.1">
        <property type="nucleotide sequence ID" value="XM_016386361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y427"/>
    <dbReference type="STRING" id="91928.A0A0D1Y427"/>
    <dbReference type="GeneID" id="27339137"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12054"/>
    <dbReference type="HOGENOM" id="CLU_057547_4_0_1"/>
    <dbReference type="OrthoDB" id="4500473at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="276" mass="30392" checksum="9A4DA916876732F2" modified="2015-04-29" version="1">MSAGATVNTRRKNWIFTPSQDYEYGGSLALGQILEDAFQPASALIASGLKLPYKDLLEDTGTKEDINIELEDHLTASFRAFCQATGVPLGANASAGTSNDSTTKWHLKKLEFKGFVPSLQYVKEALASGDVPSKTQWWKLRRKLYIVTGLRIARGSTMEKEEERSSNINLSVKADGFSQNAPVLVGAEVQGGHTKRQKESVGKISDFIFAYRLNEIKYKWSTTSHKPISHGHTASRGDASEQQQQETEPVGYDLIGLDPDPFAVKEVIDADPRVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y4P5</accession>
    <name>A0A0D1Y4P5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230117.1">
        <property type="nucleotide sequence ID" value="XM_016385985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y4P5"/>
    <dbReference type="GeneID" id="27338760"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11677"/>
    <dbReference type="HOGENOM" id="CLU_1917082_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251692" evidence="2">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="132" mass="13938" checksum="B22FAF453C4E591E" modified="2015-04-29" version="1">MLFRPQSLILLALVPSILALPQYGSYGNYGDYKLGDYGSYPSPPPSGAANPYGSYGDYGAYKRDPTAAPMKRKEASPGAAPAAVEKKEAAPEPAPADYGDYGNYGDYGTYNIPPPGAANPYGSYGDYGAYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7Y1</accession>
    <name>A0A0D1Y7Y1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231222.1">
        <property type="nucleotide sequence ID" value="XM_016384620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7Y1"/>
    <dbReference type="GeneID" id="27337388"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10305"/>
    <dbReference type="HOGENOM" id="CLU_2793786_0_0_1"/>
    <dbReference type="OrthoDB" id="4137665at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="63" mass="6922" checksum="862BC3A0930B2B0E" modified="2015-04-29" version="1">MSHFTLTTLVAATATALAPFVIVYNLPPRNQGQLRTTSSLPKPRPLATLREVKDQGKTEFNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y944</accession>
    <name>A0A0D1Y944_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231702.1">
        <property type="nucleotide sequence ID" value="XM_016385100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y944"/>
    <dbReference type="GeneID" id="27337869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10786"/>
    <dbReference type="HOGENOM" id="CLU_1219656_0_0_1"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002236824" evidence="1">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="255" mass="28142" checksum="8C772F739705546C" modified="2015-04-29" version="1">MLALIPFSWLSAMFLLSLVSRTQAVQNFNRRSDLQDVPPLNLTTAGWTVPLQGSETCDGIVGKQDCIDALTAPSADKHLQYLAIARGVYFYNCSAPNAAPVFEYQSTQLYNAAPLLASSMAEETFHALVPQLYDYDYGQLENSTLECMGTIGTDNNTAIVTLFDISTFEAIPLESVLAPNYPRENGRWAHSVSPGKSWEIYRVEVVGGSPPVCGREIANYEREYAAEYWFFHSEGEDLWTGVTQENVGASTKALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDL4</accession>
    <name>A0A0D1YDL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233307.1">
        <property type="nucleotide sequence ID" value="XM_016382604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDL4"/>
    <dbReference type="STRING" id="91928.A0A0D1YDL4"/>
    <dbReference type="GeneID" id="27335361"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08278"/>
    <dbReference type="HOGENOM" id="CLU_069193_0_0_1"/>
    <dbReference type="OrthoDB" id="5392202at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30204" checksum="ADBDBA2DD64CA6D4" modified="2015-04-29" version="1">MSKLSEPLKQLINAAHALPGYLKAPPTIRSTYSRVANSAQENGVGIPAWLTMATATTMTLNSPGSMIELFHLTQSLPSPPPAAETAGLMREVGLKCISFNGIPRTINCLGAFREGMPKDVFDSIPPQPSRQLEPDNLETSLARGRALWDSVYKPFEGKLLDKLAQSHPNLSVHILNGHYSNLLSDPPGDSPVKVGRVLTSLVAIACLRAQTGVGPQVTSHVFGLRKAYADGTAETDIEGGDWLATDEGNQWIINAVDEIVQGLSEGRGTTFAPGMGAKLQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YEU1</accession>
    <name>A0A0D1YEU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233787.1">
        <property type="nucleotide sequence ID" value="XM_016383084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YEU1"/>
    <dbReference type="STRING" id="91928.A0A0D1YEU1"/>
    <dbReference type="GeneID" id="27335842"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08759"/>
    <dbReference type="HOGENOM" id="CLU_026180_1_0_1"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="188"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="493" mass="55147" checksum="26965EF3E9D49A75" modified="2015-04-29" version="1">MLDGTSSVLAHRLQNASLLLLSLVFLPLDTFVLISSFLVAFIFPSHAGGTPRQFESATGRNSRKILVTGVGMTKGLVLARSFYEAGHVVVGADFEPNGALVCGRMSKSLRRFYTLRSPTTKSGSAPYIQSLLDIITNEKIDLWVSCSGVSSAVEDGMAKEIVEGRTGCKAIQFDVETTQTLHEKHTFIAHTRDIGLNVPETHEIRSRAEVESVLRNAPPGRRYIMKTVGVDDAARGDMTLLPKSTPMETSKHLAKLRISAESPWILQQFVKGREYCTHSLVVNGQVKAFVACPSAELLMHYEALDPTSALSEAMLAFTRKYAAVGGPAFTGHLSFDFMVEDDDRVLKAADVTLYPIECNPRAHTAVALFNGTTTMADSYLSVLDKGPTTRSSNVVRPLCNDKYYWIGHDLVTRVFVPTLEFLSLQSTVRDLMRNYIDFFTHLLTWKDGTYEVWDPLPWWWLYHVYWPTKFWSCIWTGSKWSRINVSTTKMFQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YGP7</accession>
    <name>A0A0D1YGP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_06942</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234377.1">
        <property type="nucleotide sequence ID" value="XM_016381275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YGP7"/>
    <dbReference type="STRING" id="91928.A0A0D1YGP7"/>
    <dbReference type="GeneID" id="27334025"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06942"/>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_1"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000085">
        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF75">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="13">
        <location>
            <begin position="273"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW14161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="530" mass="58020" checksum="DA7B42D926AFA5C6" modified="2015-04-29" version="1">MAGKSFVGAIDNGTTSTRFLIFDQAGNPVAEHQAEFKQIYPHSGWHEHDPLELVSSTSECIDKACEKFVAKGHSLSDIKAVGITNQRETTCVWDVKTGEPLYNSIVWTDTRTHRIVHELKAREGADELQPLCGLPLSTYPSSTKLLWMLRHVDKVKQAYDAGRLAFGTVDSWLVYKLNGGVDANVFVTDATNASRTMWMNIHKLEYDDKLISFFGLDTKTPKLHLPKIVPSSSPDAYGALASTKLKGTKIAGCLGDQSAALVGQNGFVPGRAKNTYGTGCFLLYNVGEKPVISTHGLLATVAYDFSPQGIKPVYALEGSIAVAGSSVQFLRDNLGFFPSAPKVSEVAQTVDDNGGVVFVTAFSGLFAPYWYDDVKGTLWGLTAYTQKGHIARATLEATCFQTKAILDAMEKDAGVKLQELAVDGGMSNSDLCMQTQSDIIQIPVDRPKMRETTALGAAIAAGFAVGVWKNFDELKEVNSEGRFFFKPKISQAASDKMYRRWTKAVEMSKGWEDDDDDEEGEQEEDKQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIF8</accession>
    <name>A0A0D1YIF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_07505</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234937.1">
        <property type="nucleotide sequence ID" value="XM_016381835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIF8"/>
    <dbReference type="STRING" id="91928.A0A0D1YIF8"/>
    <dbReference type="GeneID" id="27334588"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07505"/>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
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    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
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            <begin position="27"/>
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            <begin position="531"/>
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    <sequence length="800" mass="88678" checksum="A1023F855B81CC97" modified="2015-04-29" version="1">MTTLGDDLLRTVNKLQDLVFNTIGNDSLDLPQIVVVGSQSSGKSSVLENIVGRDFLPRGSGIVTRRPLILQLINIPPDEDSDANNDEVHVPHSAASVAEHGEWAEFHHIPGRKFSNFNQVRAEIENETARIAGNNKGINRQPINLKIFSPHVLNLTLVDLPGLTKVPIGDQPTDIEKQTRTLISEYIAKPNSIILAVSPANVDIVNSEALKLARHVDPMGRRTIGVLTKLDLMDHGTNALDILSGRVYPLKLGFIGVVNRSQQDIQTNKPMSEALRSEAEFFRHHPAYRNMATRCGTQYLAKTLNTTLMAHIRDRLPDIKARLNTLMGQTQQELASYGSKQFAGKEHRGSLILQLMTRFANAFISSIDGTSSEISTKELCGGARIYYIFNSVFGNSLETIDPTHNLSVLDIRTAIRNSTGPRPSLFVPELAFDLLVKPQIKLLEIPSQRCVELVYEELIKICHTCGSTELSRFPKLQGKLIEVVSDLLRERLGPASSYVESLIAIQRAYINTNHPNFLGAAAAMSSVIQNKNEKDKRAAQAEERRKRDKQRMKQLGGVNGTATPDDEEAEQDDKATALPVRKHPAMSRSMSPAVARERENGFGSISAAAGGTGGARDSFLNYFFGKENGLQSGLPSMPPTNSSATSRHVSHNVEPSFSQSIRRSDRGSFTDRSPAFPPPMNDEYAQSEYGESTSLFPEQSAEPVLTDREALETELIRRLISSYFNIVRETIADQVPKAIMHLLVNHSRDEVQNRLVSELYKEELFGELLYEDDGIKKEREKCEKLLATYKEAAKIVGEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIK0</accession>
    <name>A0A0D1YIK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016381880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIK0"/>
    <dbReference type="GeneID" id="27334634"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07551"/>
    <dbReference type="HOGENOM" id="CLU_2573911_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="81" mass="9229" checksum="9E00CF51C192D2D7" modified="2015-04-29" version="1">MTDADGSPVLLNRAWGPERAKTEKLDVLRRCIAIVLARQPANQPQHWAFECNENSGGETQKGRKARDEQHDTFLDVEAVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YM61</accession>
    <name>A0A0D1YM61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236307.1">
        <property type="nucleotide sequence ID" value="XM_016380480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YM61"/>
    <dbReference type="STRING" id="91928.A0A0D1YM61"/>
    <dbReference type="GeneID" id="27333225"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06142"/>
    <dbReference type="HOGENOM" id="CLU_009827_2_0_1"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="640" mass="72599" checksum="FB4EBA0FBA5BF39E" modified="2015-04-29" version="1">MKTARPYRSHRYPACERCHKRRSRCVVEVPGQGCIRCYTQRIPCSLASSNGANTRNAAPRIGFVHRSRLADDQALESHAFLLGPVVARDKQILDQYLPRGHEPSPSDQSRQDPEENPIYHMPIPPRMPSPTGCQCERDAPRELLAQVEPYLEELMSIYFDHISPCYPIIDEEYIMTRVRNGRHQLPQLLLVVLISHALFHWDLSPGLESYKRPDQDLAWQSAVALNAASIQKGDVATIATVCIGVSGRPCQRLVNNATNVARCVALAHIVGLNHDCQKWKIRDLDKRTRCKVWWGLLVQDRWFNFAQGTPPYISQDQYDVPVPTVDLLVPRSRSESPKHVRAAEIYIQLCHLTEILGEVLPMIYRLRGGMSTATDRTARLEVQLDSWVEDLPTWLKIGDFSQSRSHIPGLVNLQLSYLAVRMLLCRIAWHEHSLRLKTSPDDGVTEYSRLLSCQAAAEDVVRLVMSLTRSDLSGFWLPYNAHHFTSAVTLLLRCALHQTVDQATRDRCMASARTLIDRLRRHSKEDKWDLAETCLSQSESILKRIDDLPTTTIFSKTTSTATTTVNYPPRPNNLGHEMNDPIYSTLPIHGVDDTFASQPPSFTLPGQADGFSLEELFPEIFGDWCTDNFLLDQDTFSFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMD8</accession>
    <name>A0A0D1YMD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Atos-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236407.1">
        <property type="nucleotide sequence ID" value="XM_016380580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMD8"/>
    <dbReference type="STRING" id="91928.A0A0D1YMD8"/>
    <dbReference type="GeneID" id="27333325"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06242"/>
    <dbReference type="HOGENOM" id="CLU_010290_0_0_1"/>
    <dbReference type="OrthoDB" id="8625101at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033473">
        <property type="entry name" value="Atos-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025261">
        <property type="entry name" value="Atos-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051506">
        <property type="entry name" value="ATOS_Transcription_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199">
        <property type="entry name" value="GH03947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199:SF11">
        <property type="entry name" value="PROTEIN ATOSSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13889">
        <property type="entry name" value="Chromosome_seg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13915">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01177">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atos-like conserved" evidence="2">
        <location>
            <begin position="345"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="752" mass="82904" checksum="E77B4780194F603E" modified="2015-04-29" version="1">MPFVFETEDVCERRTKRRKITPYLNMARDSAQAYYDIEVSPKSQANGAQDNSRFVKQRIEERAPVPVTTSDREELIQCIKKGQRPTWVPKPGLEALCAEVNAEQKDTRANLAQSKKGSHSSKMQDLHEWERPSPTSTHSVTATESLRRSLSALHTGNFRDEQCPPADINAISTPTRPYPLASYGAPSLTAFSDVQHLATLPSPTEHSNALRRCRAPSLGNGLSSSFVMRVPTSPLVHAVNSPSLDFPTQESQCNDGSKTSRRRTMPPSAFQPLCALPLDHHPSSSANLPSTSYPHHERNILPHRPRRSLSSFTYQPASSPQLYFPGRPRRPSVTSDPSPRQRASMVGSFEESILRGRMSTPASKPLDFVAQIGVVGKGNCPPSLKCPAHVTVPFPAVFYNYPSAHNFRSISDDNPSPYVGTIDLERNLKPPEPPSRRLRRSHEPADIEDSRSEATVVEKPFSRDVSERRSKRSSCPRVPTGGAYRVPQKGQLQIIIKNPNKTAVKLFLVPYDLEGMSPGTKTFVRQRSFSSGPILENALMENNVNASAYDPLSNKDILRYLIHLKFCSTGKARFYLYDNIRVVFANRVPDGKEKLRNEVQLPEPRFSPYKPAEIGSRSPSISEHKFSSSLKESTYTDLGSLDDMLNPRVIPSDNAGEAPSMGMFHTARSEKSSLVGLNIVNGNEEMCAAADQSVPAVSGFLPSTSSRNSPVPWLDPSGNPVARGLSPAPLEVGDGLISRKLRELNGTAGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNE4</accession>
    <name>A0A0D1YNE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236807.1">
        <property type="nucleotide sequence ID" value="XM_016378130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNE4"/>
    <dbReference type="STRING" id="91928.A0A0D1YNE4"/>
    <dbReference type="GeneID" id="27330862"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03779"/>
    <dbReference type="HOGENOM" id="CLU_007383_12_2_1"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="348" mass="38416" checksum="42A837362DE4A50A" modified="2015-04-29" version="1">MPPKVFLTGTTGYIGGDFLYLVSERHPDWELTCLVRNSDKGAKIATVYPKVRLVYGDLDKVDLIEEEAANTDVVYHFADCDHVPSSQAISRGLARRQRDGVGYWIHTSGTLILGYETIVKKVFGERLEKVFDDWENVNELTSQPHEAPHRDVDEVVLAAGSDKVKTAIVCPPTIIGAGRGPGNARSKQLYRTTETFLKHQQAFKVGKGENIWHYINVQDLSDLYLLLGEAAVNGGPPATWNDQGYYLAENGPFVWGEVLQEVAKIAHKEGLLPDSTLKSLSPEDADKIMPFAPYSVGTNSRGVSQRGKKLLNWTPKMRDIHAEVATAVDGEAHLLGLKKSHAEKVVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YP85</accession>
    <name>A0A0D1YP85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_04162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237187.1">
        <property type="nucleotide sequence ID" value="XM_016378510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YP85"/>
    <dbReference type="GeneID" id="27331245"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04162"/>
    <dbReference type="HOGENOM" id="CLU_052827_4_2_1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19433" checksum="B8683921EA229007" modified="2015-04-29" version="1">MKLHPDFNVQWCRSILSSNISNLVNGREVLLDPSSPISNSIFTQSLYTSSAIRAHLSFQRPTSEPDSIGPLEYCYLLSLGSGVDGKRARAHGGFNSLILNHLAGMTACEVFGSVTLAAATMKVDYKAPIDTPGVIFARGWAVARDGRKLWVRTDIEDAKGQLLARAKVLFINQRSVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUY4</accession>
    <name>A0A0D1YUY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239292.1">
        <property type="nucleotide sequence ID" value="XM_016377722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUY4"/>
    <dbReference type="STRING" id="91928.A0A0D1YUY4"/>
    <dbReference type="GeneID" id="27330451"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03368"/>
    <dbReference type="HOGENOM" id="CLU_018202_0_1_1"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF30">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="153"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="502" mass="56063" checksum="CE95107B9797D86C" modified="2015-04-29" version="1">MSQRPATRPASAILSKHFFLSVVAPLHIQPKQFYRLSIQVNTPQQIRQHREAHSRRNVSSAAPSIVETGHVTTSVPVSRPLSCLSLSTLIRSYLITSVSSIPLLLRPSLSVMSFLAHTKSPFFMPDRNPFLHFLLKKTFYAQFCAGETPSEVRATIADLKHTGYSGVMLGYAKEVVLTKEDAEELDASRDSSDQAALNAEEIATWKRNTVATVDLAQAGDFVALKFTGAGRQALQHLKATIACSHEFEQAVHEICQSAQQKGVKLLFDAEQASLQQGIDNWTMYFAKIYNKEQAVVFGTYQAYAQRTPQVLARHLELARNENFVLGVKLVRGAYLGSDPRELFWPTIEETHKCYNEIAKAVLQRQYQGILQPVAGCSSEFPQVSLVLATHNAESVRLAGKLRDEQARNGQPRIELAYGQLMGMADNVSCEVVQTARSRSESSEPNVEIPRAYKYLVWGGLGECMKYLLRRAHENRDAVTRTVEARRALGNELGSRLAFWRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXS7</accession>
    <name>A0A0D1YXS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240287.1">
        <property type="nucleotide sequence ID" value="XM_016375011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXS7"/>
    <dbReference type="STRING" id="91928.A0A0D1YXS7"/>
    <dbReference type="GeneID" id="27327729"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00646"/>
    <dbReference type="HOGENOM" id="CLU_373389_0_0_1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="46"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="492"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="616"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="399"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="719"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="736" mass="73850" checksum="CCD0D7A98901755B" modified="2015-04-29" version="1">MPCAGNSSLLCGGPSGLTLYNNTQWALMTAAPSQPTGPVTVPSAGRYQYVDCHTEVSNGRALSGSAIVSNDMTVQYCAGNCTGYAFFGVEYGQECYCGNTLNTGSVTATDQRCSMTCAGNSSTICGGPNGLSLYKLVVASLSSSISRSSTSSILASTSVNPSQIANSTTTTAPSIAPSSHSSNTIRATTSSSFAMFISVTTSSTSSKSSVSTITTLSLSSASLPTSTLILIDTSISNPTTSVRSTSSANATATSGINVSSPNATSLRTPPSSSGRTSATSASGTLASSSWTVSTSRSESPAYVSTSGAASYVSSTGSGTTIRSSTTSISSLSILVTSTTARASSVSATSVSSGFSTIFVARTSTTSATFASTSSSSATTGISTLVNSVTSQTSTQPRISASTSNSGSGFVSGSTSTPPRTSSTYQGSVTSSSSSSKPSSLFTTNISTTSSSTRLTTTTTARTTTTRSMLGSSTTTTSPIPSSTTIAADPFLPNVYIGCAAELSNIRLLSSASFTNSSMTIASCLSFCTSQFMPLAGLEYGRECYCSSSLPPNTPLNQTGCTMACAGDGDVDVTQPTCGGRSRLSIFNNTLLSPPGPKPVISPPSPSASPGGSVYYTYAYQGCFTDPSSSQRALSGYSASDSAMTQEKCVATCAGRGFKFAGVEYARECYCSDTLATAGGSGSGNGKSLQVGEGDCGMPCAGDKSEVCGGSSRIGVWMASSSSSSSSPSSSPSSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZA0</accession>
    <name>A0A0D1YZA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor spt8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240832.1">
        <property type="nucleotide sequence ID" value="XM_016375556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZA0"/>
    <dbReference type="STRING" id="91928.A0A0D1YZA0"/>
    <dbReference type="GeneID" id="27328274"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01191"/>
    <dbReference type="HOGENOM" id="CLU_010934_1_0_1"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="3">
        <location>
            <begin position="135"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="3">
        <location>
            <begin position="487"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="657" mass="70666" checksum="15A491A5FF294F25" modified="2015-04-29" version="1">MGAFDEDDDRSQDDFDNDNDNDNDETMQDLDEGDPDNDGEGEGDQDGDGDLEADADDGEGEDEGEGDGEGDGDGDDDDEAGSQSGGSQKSDNEEAPGEPSATQEGQQSSAMQPDEAREAAARAKISPEYLDASTYDIVPTIAAPQSTSINAVCATGDMRWVFSGGSDGYIRKFNWVDTVNNKLALTVAQRHPFVDSVVKAGVLMSYWENWDARPQTTQNISPVYSLACHSQGLWLLSGTASGPIRLQSIRHDEGREIALLKKHTSAVSVLTLSSDERSLLSGSWDKTVLDWDLETGQVRTTFAASASQISAIESRPMSSVPVPPESGEVIVPNGTFSSTDVKTNGIKSEQLPNQTTQEQPSVATPDSLFGDGDDDLFGDGGTAVMGNGGDLTDAFVDADDEMSRALANESRPEELIDHEMQDAMESTGESSTVPQLIADLDDNSKIMTNGGPNTHEQPLANGLPHTDDMEKQPDEQAFAEDADAPPTSDSTFLATSIDGAIRVWDRRQPKPVARVLPRNTPPWCLSACWSVDGNCIYAGRRNNTVEEYDLRKGLKTSERVFRFPNGSGAVTSVKAMPNGRHLICASHDILRLYDLKESQGQRSAVPFLIVPGHRTGTVSHLYLDPACRFMLSAGGNRGWEGASTEVLLGYEIAVPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z9R5</accession>
    <name>A0A0D1Z9R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_12006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847503">
        <property type="protein sequence ID" value="KIW09722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229938.1">
        <property type="nucleotide sequence ID" value="XM_016386313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z9R5"/>
    <dbReference type="STRING" id="91928.A0A0D1Z9R5"/>
    <dbReference type="GeneID" id="27339089"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12006"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="2351791at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF94">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW09722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="500" mass="54287" checksum="80AEB49A36A09083" modified="2015-04-29" version="1">MVSRSSATAIWRPSAGDIACMMVLALLSFLAAIDSTILLITRQLHGTTIYAFWTGTSYLMTSAIAQPFISTISERLGIHMRMIWFSVSAFAAGSIICALSRDFIPLLAGRSLQGLGGGGIITLVQIIFARLVPLRERPKWFSIVLTTWAVGSVVGPFLGSVLTTTSTFHWIFWINLPICGLALVVIPFTIPSFRPTAQCSWSKVDWAGGAIFFTSLTSVLLGLSWGGVTFPWTSKWTISSVTLGFCGTLLFGIWEHNFPKFPIFRPSLFNTASRIALYFCSFLQGLILFCLLYYVPLYFASAQQQTPMVSSACVLPLSCSLLPGAAITSQVITRTGHYKWILGMGWILTILGSGLLLLFEEDTGPTVWILILLIIGIGNGCLLSALNYHVQATTDPSSSASGASMYTFFRSLGMCVGVTVGGNVFQNVMAHVLSKAGVSTSIAKDAEAFIYELTLLDNTDTMLQKILHAYVGGLHGVFYMLLGVSILGLMANTYIYVYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAK1</accession>
    <name>A0A0D1ZAK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230218.1">
        <property type="nucleotide sequence ID" value="XM_016386086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAK1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAK1"/>
    <dbReference type="GeneID" id="27338861"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11778"/>
    <dbReference type="HOGENOM" id="CLU_035325_0_0_1"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="535" mass="57085" checksum="45B588AD9A895E79" modified="2015-04-29" version="1">MSIDAGGLAQMTYQSPFNNSIGVSGPGFASRGKGSHIKRLSVAPPPKISTIDETQQANVGTTPRTSRGHLLAGLRTAPKSATVPPPTNGMGVEGSRYPSSQYGNRVPQTATGSYFPNKRASYHAGTYPQNYSLPEHVLAPPSLDFVDPADHMDQNLYDELVATNNYLAQQQRALQQQLLSVTAAAQQLGGLNLNSAMMTNPGQQFQSPISSPMSMYSQQFQQGLQPVVQPVPGSPGVFAVYNPMTGQSNFVFDHSIQQQQDSSSARRNNSVSPPPANAGYQRQFGEPHPPPEIRSRTPPKSTPSPQIDVEPLPPPSANAFRRGHRKNASSVNIKTTVEWAKGTALRSAGVPQTPMTGTFGPGQGRAGEHPVRQPKNPPHLQELQDKPTSKHEGSKNFATRQRRQAVHDLVRAGRERRSDGRQSGSGAGTPGSENEFNFSVSSDNDSVLAGSTSLSSKPSMGSLRAAASGVIGGERKEISRERGSVDSIGAISAKSLSSDEGNFIGGSIVEVEQSARRNTPLLVLSNAEKRKSVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAL0</accession>
    <name>A0A0D1ZAL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230233.1">
        <property type="nucleotide sequence ID" value="XM_016386101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAL0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAL0"/>
    <dbReference type="GeneID" id="27338876"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11793"/>
    <dbReference type="HOGENOM" id="CLU_033323_13_0_1"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000022">
        <property type="entry name" value="Phosphoglycerate mutase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27642" checksum="44215CAA39ED8907" modified="2015-04-29" version="1">MTTPRCFIVRHGETEWSLSGKHTGTTDIPLTKNGEKRVRATGRALVGDDRLIVPRQLVHIYVSPRHRAQRTLELLDLGCHDPYPWQTNSDNHSPTHNKTDARVTIDPRIAEWDYGEYEGITSAEIRKLRAEKGQGPWDIWRDGCPGGESPEDIIRRVDSLIADIRENYHAPVIGKPKDQGVTGDVMVVGHGHILRAFAIRWIGRPLTETSLIMEAGGVGTLSYEHHSIDEPAILLGGGFVVGEEPKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAW7</accession>
    <name>A0A0D1ZAW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230373.1">
        <property type="nucleotide sequence ID" value="XM_016385429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAW7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAW7"/>
    <dbReference type="GeneID" id="27338201"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11118"/>
    <dbReference type="HOGENOM" id="CLU_032410_4_0_1"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="470" mass="53137" checksum="789CD3279218C5EF" modified="2015-04-29" version="1">MATAVDQKLLRQTKFPPEFNQKVDMKKVNVEVMKKWIAGKISEILGSDDDVVIELCFNLLEGSRFPDIKALQISLTGFLDKDTPKFCKELWNLCLSAQSNPQGVPKELLEAKKLELIQEKIDAEKAAANAQQRKDQEKVREQEVDTVRQRERAERGRGRGRGRGGRDFDSRRPRYSRSPPPRRRSPFGGGPPRREADTYVPGGRGRGRGGRRGRSPTRSVSRSPSRSPPPRQHRRRPSPSSSRSPSSSRSRSPPRRRARSESRSRSRSSSGGPGFKKPRRDSHSHGERRARSVTRSDPSHSPSPRRRPLSRSRSTISRSPSPRRHGRRSSRTYASSASRSRSRSLSGRRGNVGGRRYRRSPSYSSDDRGSNRRADVLKGRNAHDNRRLSRSPSPTPYRRRRSTSNSASPGARRHHKRRSSLRRYEPAARRRRNTSSGSSPEQKRRKRDESGGEGLGRRSVDGEGVGETDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZBG3</accession>
    <name>A0A0D1ZBG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230588.1">
        <property type="nucleotide sequence ID" value="XM_016385644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZBG3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZBG3"/>
    <dbReference type="GeneID" id="27338417"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11334"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="464" mass="50983" checksum="C12ADD7D266237F3" modified="2015-04-29" version="1">MPLTSNLHVGICGGGMGGLAAAIAAARAGAKVTLLEAARELGEIGAGIQVFPNASRLLIRWGVDKLIGDNLIVVDEANTWAADGSLIAHFDPKEGLKQSGFPHWLVRRDHLHAGLTESARHHGVNLVVGSRVNRLDCTQEGVKVTTTQGTAYEFDLLIGSDGIKSFIRQTLFPGVVPQAASTVAAFRGILSYDEVFNKVPEARHLLRNTMDAWIGPNGYILLYPLSAGAELNVVTLFQMDHIVERPEDMNIDEFRHLYKDWNPTARKILELVNYTQKWPLLVLPPMKTWSNEFKNVVLLGDAAHAMQNHMAQGAATAMEDGAFLGTVIGDAIRGNITLSEAIDLYEKQRIPRVWVKQQASFISGTLNMATGEEATRRNRASAPEVNAWSCNVVRPSDALPPTYRSWQMYCTPTSVPGILYYDAEGDADNAVCEYLQSTTRMDDATLVTDGLWKRWWGVIDNNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZDB3</accession>
    <name>A0A0D1ZDB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glutamate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231178.1">
        <property type="nucleotide sequence ID" value="XM_016384576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZDB3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZDB3"/>
    <dbReference type="GeneID" id="27337344"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10261"/>
    <dbReference type="HOGENOM" id="CLU_011856_0_0_1"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="384"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW10962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="63271" checksum="E2BB12DF5C626A88" modified="2015-04-29" version="1">MSDHNQRLKQVSSQHEINGYKSQATNGSSKNFQNGTVTPSRASELKRLLNATLEQLIPFLQRADDEVQAHQLHQPTDTTSLVESHPPSELRSILSRDGTLSLPDDGTGQTGLLDSLASILKYSVNTSAPGFLDKLYAAPLPPGIAADLILSVLNTNLHVYQVSPVLSLIETHVAKALASLFGFTGPTAGGINVQGGSASNLTSIVIARNSLYPETKTLGNHAGGLRLVMFTSEHGHYSIEKAAQQCGFGTESVVSVPVDPVTGTMDPVMLESLIVREKEVNGTTPFYVNATAGSTVLGSFDPFIEISRVARKYGLWMHIDGAWGGSFVFSETLRERSLRGCELADSIATNPHKMLGVPVTCSFLLLKDLRNAHRSNTLRAGYLFHDEEEDNTNGDGSRSTDGAEGEEDGAWTPPEDLADLTLQCGRRGDSLKLFLAWQYYGTLGYRTKIENAYSVACHMVQLVEAHPDLVLVSTNPPPCLQVCFYYAPGGKMTFDLEGQVQARGSDRIQVGKRNSAITSRITQRLVSRGFMIDFAPALSNAVEKGSFFRGVVNISTTKGTVERLVEELVRVGKDVTEERRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZEB6</accession>
    <name>A0A0D1ZEB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA mismatch repair protein msh3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_10647</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of msh2 and msh6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231563.1">
        <property type="nucleotide sequence ID" value="XM_016384961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZEB6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZEB6"/>
    <dbReference type="GeneID" id="27337730"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10647"/>
    <dbReference type="HOGENOM" id="CLU_002472_10_0_1"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000523">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000015">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000017">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="15">
        <location>
            <begin position="735"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW11347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="926" mass="103258" checksum="7D7C4C1EFA7424E7" modified="2015-04-29" version="1">MASRPELKVDDEGGFIRTFRSLPAKPEGTSTIRVFDRADWYSAHGEDAEFIARTVYKTTAVLRNLGRSENALPSVTMTTTVFRNLLREALFKLGQRVEIWEASGKGQWKLAREASPGNLQAVEEELGSGIDSQGDSAPIILAVKVSAKTGEARNVGVCFADASVRELGVSEFLDNDLYSNFESLLIQLGVKECVVASDGQKKDPELAKIRQIADSCGVAISERAAGDYGTKDIEQDLSRLLKGENSMGLLPQTDLKLAMGSAAALIKYLGVMTDPNNFGQYRLYQHDLSHFMKLDAAALRALNLMPGPRDGAKSMSLFGLLNHCKTPIGGRLLAQWLKQPLMSLEAIETRQQLVEAFVTDTELRQTMQEEHLRSIPDLYRLAKKFQRKMANLEDVVRAYQVVIRLPGFIEALETVVDEQYQIPLEAQYTSKLKELSNFLGKLAEMVETTVDLDALDRHEFIIKPEFDDKLRMIRSKLDQLKNNMDSEHRRAGKDLNQDLDKKLFLENHRVHGYCFRLTRTEAGCIRNKPLYKEISTQKNGVYFTTSKLQELRREHDQFSTAYNRTQGSLVAEVVSVASSYTPVIEQLAAIIAHLDVVVSLAHVSVHAPTAYVRPKMHERGTGDTILKEARHPCMEAQDDINFITNDVELKRDESRFLIITGPNMGGKSTYIRTIGCIALMAQIGCFVPCSEAELTIFDCILARVGASDSQLKGVSTFMAEMLETANILKSATRDSLIIIDELGRGTSTYDGFGLAWAISEEIVAQIGAFGCFATHFHELTALADKYPKAVKNLHVVAFVDQASGDTSEKREVTLLYRVEAGISDQSFGIHVAELVRFPEKVVNMARRKAEELEDFTTATGEKKKEEYSKEDAEEGGKLLKAMLKTWKSQVEGREMSKDQKLQLMRDLVKADSALMANPFFQSVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZFI1</accession>
    <name>A0A0D1ZFI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231973.1">
        <property type="nucleotide sequence ID" value="XM_016383350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZFI1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZFI1"/>
    <dbReference type="GeneID" id="27336112"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09029"/>
    <dbReference type="HOGENOM" id="CLU_011937_4_1_1"/>
    <dbReference type="OrthoDB" id="4220776at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF4">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="81496" checksum="3740A927306C68D3" modified="2015-04-29" version="1">MPRRKKLTTVNLSSGGSYSSHTTDDVCTLDVLARKYEEALSETRPTTLYAPNTIYHVDRIQRLFEEYCDKFQLDPQETLRECATARMENFLHWLLRTYTIKKTSTLTTYWRQLSQLYIMWTQRRMDPAVMRQIFVFIEGPLTEEYGLDNEEIEKPLMEADDFVELIRYHWASDINWFPNERQRLQLAAILLLAAFTGSRPQALLDLTYRDLDLYIEKDAETRVDMLRLGVKLTKTKSRQKRKRPKTYTFNLDDNPIFCVITHIVSLAFDDSAFGPPDLKSPDVLFRLRARREKGCQPIPWRKEMLDVPIFRRAIATKEGVKTSPDRALTYNVYQAWVKRLGEALGYLQTLTTYCLRRALGNAINDDPKSNAAVRNLALDHVGSSTIFERNYLSRMIRYSTQDAFWNREANPQAAKSASRIGRLRDPNRPRKLTDEQSQQVRRLPSVRRLLESRDRVRGVILREFGFFRMAIGEPIHAEYKKLERMVNSTIRAEERALLKCIQRQSDETAPVEAIQRQIKGTSAEGQELTSESTPTQIKIPERRQIAEAAMSDPAVFTGPKALSRHIKCSATMISLCRQREGRRETRRERLSRKYSRSTGETDTATTVVSTLTLPLSSTPEGCVPLTCQGFQCLFCLCSNIPQEDREKRYAGKHSLQRHTERCRLRQFQEKDRIPCPDKVACRGKVFEGKSHFKNHAASVHLFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZFQ9</accession>
    <name>A0A0D1ZFQ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232048.1">
        <property type="nucleotide sequence ID" value="XM_016383425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZFQ9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZFQ9"/>
    <dbReference type="GeneID" id="27336188"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09105"/>
    <dbReference type="HOGENOM" id="CLU_590542_0_0_1"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="54578" checksum="4997F2504D33A0D8" modified="2015-04-29" version="1">MSHPVPTPDPSQYDTFRGDVCSHEWSPVSWLSQNRSDPFATDTADSPQVSELLDHAVQHFWSHLSPSHHFGSYNPVNALYLAHMQSSQMAYHSYILVISTNLDYLRMSSLRQNVFQSMRLRCIHAATTLVRELIDSMPPQPTRGDVPDELIGSILSLSCCHALPMKSANHPVSRFSSPLATAQCLDMWSATPFLESHRRAVVQLVKLKGGLEALDSIYLAAVVQLNDLIDASRKTRKPTWPWQNTVIASCSSSAVRPFVATALLTYDNDLATAFFPLTKYLPCGHELERAILAVAEATAMLKIYKHNITSRMAEMVQLRNRAQYFVLDLDPLPLLVGPDEKDKEYGRGRQCAAVHVPSFLYEVIRISLLIYNNLVLYPMSPATGVETRLATRLKFILCSGLQAQLWNVPQYTDLLLWSMMLGGISTEDIEDGKWFQTQYFELARDRNRLRSWFSTVESLSTFIWLDFVLNEEAEKFWATLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZGP4</accession>
    <name>A0A0D1ZGP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232353.1">
        <property type="nucleotide sequence ID" value="XM_016383730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZGP4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZGP4"/>
    <dbReference type="GeneID" id="27336495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09412"/>
    <dbReference type="HOGENOM" id="CLU_061829_1_0_1"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="212"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="297" mass="33066" checksum="2C6D2ED122409369" modified="2015-04-29" version="1">MDLQKDQSVQEEDGFIDIQHADVDMPDSEADDATHSSTAPHELQRFSNNLDPEDAVDDHEDDSEDDHDAMANHPLLSMLTGRLGARRRGSSHEWDHLHPENQALSVANADECFSVEESVFPPEERASREKFHYRLTRCPELSLGLFTQPTKAEAEGSSTPAKRRLMAHVVSTRSPAPCVTEASMKVPSNWRNRRSSLPSSTEVELEGHQETGGTICLHSLAVAPEFQKMGLGTVLMKSYIQRMKDSRCAERIALLAHDHLIPFYASLGFENMGPSTVTSCGTGWNNLILEFSHDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIA9</accession>
    <name>A0A0D1ZIA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232823.1">
        <property type="nucleotide sequence ID" value="XM_016384200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIA9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZIA9"/>
    <dbReference type="GeneID" id="27336968"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09885"/>
    <dbReference type="HOGENOM" id="CLU_054544_0_0_1"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43796">
        <property type="entry name" value="CARBOXYNORSPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43796:SF2">
        <property type="entry name" value="CARBOXYNORSPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="463" mass="50425" checksum="FA7C098445D84985" modified="2015-04-29" version="1">MDATQHSSKPVVFIGAADAICGRAIESFVAASTLPIVLADADESAIRRNTTKLSPNRATIKQTNIYEPSELRSLISGARLVVQGAQPYGRASGPVLGACLDAKVPYLDYSDDVKSTQDSLDLFERAEQQGVPCYINCGSSPGLTNLMAVDAAKELESVDTIDVAWYVTDRGGQNGKEVLEHLMHITAGPCMTWADGKPAVHENWVETSYAPMIPGEGDVLLHETIHPEPVTLPRAFPTAKRVRCLGALNPLPFNGFSRGLAVAVREGALPMEVAIEFLWNLATRPTTAVDGAASDSSSWLEVVKAQLRGGDIKLRELYQLACHAAGALDPWRHAIWGMIRQVQDGECSLVDAARFMVNSARGRHPDYRAGILVRVLGTRNGVPTVVYRRQATTIQDPEESMAVNIGSSCAAFLLMVTETELDPEGLKRAGVFCPEDWAELDTYYKAMERLGRRQKDNIESFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZK16</accession>
    <name>A0A0D1ZK16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233383.1">
        <property type="nucleotide sequence ID" value="XM_016382680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZK16"/>
    <dbReference type="STRING" id="91928.A0A0D1ZK16"/>
    <dbReference type="GeneID" id="27335437"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08354"/>
    <dbReference type="HOGENOM" id="CLU_005609_0_0_1"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="723"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1038" mass="113267" checksum="C0F1EAED14E2F2F8" modified="2015-04-29" version="1">MSDNGSNLSRRSSSQTSHSSATAEHKKPKTLRGLPKRHGSKASARSFEDDDPALTSFPSFSPEPEQKSSSVIQEVVSQPLRTVSQRARDRKATLAGLTNASPSFNKQNALFDDSPRSSLDIPGSLHLASDGHIERLISKTGAVKLIRQYASDLAQRDAEISALRIRADNRERELKRLLREASVSTPEVEKRLLRLEQGFPGPENQSLSGSSDHITSVITLDGMMSEAMEEGILVNSPVDEPFSADLTRDGPDPNFSQVDNNQGGRSRATSTASTQLKGSRTPSRANSSISENSQDMDATLRPKVSGINPTKLSGLQSIFQPPSQTTSYFIGGKSLRKPKLGDEISVRSNQSARSFTSWTQIFSGKTQPGRSRASSLGQDANGNAALPTDAEASLSSLSKIKTQVAGKSSASLPASDNAKMRPPPRRAPTPNRLNTSPNHVRKESNASNLPPTVELDSMIESSQLPPTMTSQYDDKHGLLTDRYGFIFDQYRRKRENLQVRVHKKNKMSNTETLANLRAGSPGSEDVFSDRPSTPASVDDETPKKAWSDYLKVPGALSSGRPKELLSHTPSAGAVVTVSTADGVTPTTPPHRSREASISVNLSTQKAMPTTSVVVEPQHSAITATSSDLTADSENDTYNDSGPTKILLDQLRDLHDALQTERSARWNDFLRRVRAERASNTDRGANNPPEAELLNGELIGIATLGRSKQTRNKYLHFKSLVLAGIPVSLRPKIWAECSGATALRNPGYYEDLVARSQDGTDVDPDIASQIKADVRRTLTDNVFFRHGPGVQRLEELLRAYSLHNPRIGYCQGMNLITASLLLICATAEDCFWLLVAIIDVILPSQYFSSTLLVARADQIVLRQYVTEILPRLSAKLEELDVDLEALTFHWFLSLYTGVLTGGEALYRVWDVILCLNSSDALPYGFDQPKNLTVEVPGLGRSQPSTPVTPAMPESNADNEHDGTSSPFLFQLALALLKLNENSILALDSAAQVYTYINHNMTNHAISIDALIQASEGLRVKVKRNEVLERRKAAIKELGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZLG4</accession>
    <name>A0A0D1ZLG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233883.1">
        <property type="nucleotide sequence ID" value="XM_016383180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZLG4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZLG4"/>
    <dbReference type="GeneID" id="27335941"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08858"/>
    <dbReference type="HOGENOM" id="CLU_027816_0_1_1"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="82"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="523" mass="57498" checksum="B276C8F81DC68525" modified="2015-04-29" version="1">MATFQDKDEPFGAGGSFGPGDNVDLERRASTTTVQGRKMSRIAPPPRNSSIVSTPEGDDDGVKDEYGKLVQMEANDAIKYRTCSWQKTAALLFSEYICLAIMSFPYSYSILGLVPGLILTVVQAAFVLYTSLVVWEFCLRHPETRDVCDIGQMLFWGSKWAWYFTAVMFLLNNTFIQGLHVLTISRYLNTMSDHSICTVGFAAIGAVISWVCSMPRTFSALSKLGAASAFFTFISVILAAAFAGAEGKHGTAGYNPDPNHINANGQKVGGEPLVLAVPLAGTTFVSGMNAFLNIAYTFIGQITLPSFIAEMKNPYDFRKAIWVVTICEIIVFSLVGGIVYGYTGTQYNTAPAFYSLGNDVYKKVSFSFMVPTLIFLGVLYASVSARFIFFRLFDGTRHKSSHTVVGWASWAGILAITWILAFIIAEVIPFFSDLLSLMSSLFDSFFGWIFWGVAYLRMRYADLGPGFYKKRGIRGWIGFLVNIFIIIVGLYFLGAGTYTSVESIILDYDAGNVKGVFTCANNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQ28</accession>
    <name>A0A0D1ZQ28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_07692</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235123.1">
        <property type="nucleotide sequence ID" value="XM_016382021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQ28"/>
    <dbReference type="STRING" id="91928.A0A0D1ZQ28"/>
    <dbReference type="GeneID" id="27334775"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07692"/>
    <dbReference type="HOGENOM" id="CLU_034391_0_0_1"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="9">
        <location>
            <begin position="134"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="22"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="609" mass="65846" checksum="B17F70DC3FC57728" modified="2015-04-29" version="1">MPLSDGIPSSPPGPGSSLEDSLKYYKAQYELLEAELEEFQTSSKELEAELEKDIDASEKRERQLKEKASNLQYEVDEWKAKYKQSKTEASNAQNALQKEITELRDANRNLQMRLRDIEVANDDFERKQRNTESSLEDMEAKYNQTIERSVLLEDELRSSEQDREGLRIEAQRLRDELSDLKIEADITKEKLRKAEATARKRLTLHPIHITSSSPRSELSPTTTNASSPTFDTPPAKTASSSGLSDTPTPPSPPISDNSSNVSKPFATPGIPKRSSLAGATAIQRPPSSISNSRPNGHVRGPSVLSRTGPSASFRQSLSKNSALPQRSSGLPQSASLVHIRNLRGKMQKLEERVHNARSKLPAPVNTPPKMSPRSGSALGNHIPSSVTVRTRKRTGGSTISGADSLPDKAQESPLKARARPSTSSLSFQQPPSPTRGDMAAPPPLRPSSRTSGISGRSSFVPSHSRPGSRASVSGFRAPLGSGVGSNYAPNASTDRIRPKSSLSSYGYDGTLDEDDSEMALGDVKDAATPTPRRTTFAKRSSDIGTSIPSPSKRTSFGSAATTKLPGLGRRPSASFVRVASGPGPGSGDMRPPSRQLDHVQEGYDVNESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQ61</accession>
    <name>A0A0D1ZQ61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-dependent oxidoreductase 2 FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235143.1">
        <property type="nucleotide sequence ID" value="XM_016382041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQ61"/>
    <dbReference type="STRING" id="91928.A0A0D1ZQ61"/>
    <dbReference type="GeneID" id="27334797"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07714"/>
    <dbReference type="HOGENOM" id="CLU_022946_0_0_1"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014614">
        <property type="entry name" value="KsdD_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009472">
        <property type="entry name" value="PRK12834.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260">
        <property type="entry name" value="3-KETOSTEROID-DELTA-1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260:SF1">
        <property type="entry name" value="KSDD-LIKE STEROID DEHYDROGENASE RV0785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036654">
        <property type="entry name" value="UCP036654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="569" mass="62544" checksum="7342B5BCC0820D7A" modified="2015-04-29" version="1">MGNSQQSEPVVIVGSGLAGLVAAYELTRKNMPVVIVDQEPEGSLGGQAFWSLGGIFCVNSADQRSKGIKDSRELALADWMGTAKFDREKEDYWPRKWARAFVDFATDGMEPYLKNLGVKFLLVGWAERGAGDAAGHGNSVPRFHLTWGTGPQIVRAFSEPVRRAEKKGLVKFLFRRKVDELIVEDGRVVGVKGKVLADVKNGWVRGQATNRDVVGNFEVRGRAVVISTGGIGGNVDKVKENWPVHRLGPQVPGHFVVGVPAHVDGEMIGVAEKNGANVVNMDRMWHYTEGLHNWNSIWPAHGIRVIPGPSSMWLDAKGKRFPPFLYPGSDTLATLKHIVATGSDYSWFICNRKIVSREFALSGSEQNYDLTEKSYIRLLERLFSSLGTREVQAFLKNGEDFIVEKDLDKLVEGMNRLAKERGGPELDLEKVKKEIELRDMQVSNEFGKDAQIMLIRNARNYGPDGRRIAKPHRLLDPSAGPLVAVRMNLLTRKSLGGMETNLDGNVMKPDGQPFKGLYAAGECCGFGGGGVHGYSSLEGTFLGGCVFTGRTVGRALVKEILPKVNEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTS2</accession>
    <name>A0A0D1ZTS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_06228</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236393.1">
        <property type="nucleotide sequence ID" value="XM_016380566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZTS2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZTS2"/>
    <dbReference type="GeneID" id="27333311"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06228"/>
    <dbReference type="HOGENOM" id="CLU_012678_0_0_1"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000010">
        <property type="entry name" value="EH domain binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ENTH" evidence="12">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="153"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="334"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="522"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW16177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="560" mass="62178" checksum="9CA22A021FFA81FA" modified="2015-04-29" version="1">MSKVVRSVKNVTKGYSSVQVKVRNATSNDPWGPTGTDMAEIAALTFNNPSDFYEIMDLLDKRLNDKGKNWRHVLKSLKVLDYCLHEGSELVVTWARKNIYIIKTLREFQYIDEDGRDVGQNVRIFAKELTSLILDEDRLRSERSDRKVWKTRVQAMDDSANQPVTSPSRRQPPRHSAADEDEDLEYKRAIDASLEEAKREEERRRRQNADQDSDELQKAIKISKEEEEMRRRQLEDANAASLFDDTPAPSQPQPTGYNQGYQQQPAVDWFGNPLQQQPQSTGYLNNQYAQPMQTGQQNGFTNGFQPTQPTGYDQFGQQPFLQQQNTLQPQQTAFQTNNPYGAQPYGDVFGAQSPQAHSLLQPGTNNPWATQSPQAAEPLRPLPTGSNNPFAQRPQQASPSPFQRTSTQPSLGTLMEAQPTTNFSQPTQPNPIMNYQPSPQPSFQQQQQQKPINPQHAKLNALLASGEGQDTFGNTGDLRLPAQHTAPGAFVNSAGQGIDRLRAAQTGTNPFFSSQATGYAQQIPNQTGPVGGFGGGYGQQNSNAFGGRPGGPQSGSLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZUL8</accession>
    <name>A0A0D1ZUL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236663.1">
        <property type="nucleotide sequence ID" value="XM_016380836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZUL8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZUL8"/>
    <dbReference type="GeneID" id="27333583"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06500"/>
    <dbReference type="HOGENOM" id="CLU_009665_3_0_1"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="308"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="393" mass="42689" checksum="61C5E0B2B0949695" modified="2015-04-29" version="1">MTAPILIVGAGLGGLSLAQSLKKDGIAFKIFERDSTASYRAQGYRIRISQHMLKKLLPQDVFATLEKACPDVVPGGRRIDAITGETHEGAGGPNLKDQHSWNADRTLMRTILMTGLEEHIEFDKKLERYELAGEGVTAYFTDGTSASGRLLIGADGVRSSVRKQLVPDQVILDTQVRAVFGKTPIRDGPLVPADVDKGITVISEPPPTAAVKLFCDGMRFDRDVDIAVKLPEDYIYWVLLFPKTRVSISDQDLLSLDGEKSVQLAQHLTCDWRRSNRAIIDHADTSACAALAFEMAAPEHLGWTPNAKVTLLGDAAHPMVPVGALGANAAFEDAVCLAAVLRGPVNEEALSTYEKDVTTRARAAIEQVLGPGRGLLGMKPIEELKPSSLWTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4D4</accession>
    <name>A0A0D2A4D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_00281</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239923.1">
        <property type="nucleotide sequence ID" value="XM_016374647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4D4"/>
    <dbReference type="STRING" id="91928.A0A0D2A4D4"/>
    <dbReference type="GeneID" id="27327364"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00281"/>
    <dbReference type="HOGENOM" id="CLU_051870_1_0_1"/>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW19707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="369" mass="41139" checksum="1686268D4C2A961F" modified="2015-04-29" version="1">MPPFNPTVTELYRKDVASGGRLLSAAEREKLLQPYLPPVPAPSSRMDSITSTTAPRHASRGHKRRIRPFLKTKIHTLLFFLIQLFFGMYIRLRQIYHATLDRGLAIRHYHHRTPEYIQRDVKNLDRLPRHLSVILKYKSEEDGGLEALVDEVAELSAWSASAGIPLLSIYEKSGILKTYMASVQEVVSQKLTSYYGPAPAAPSLRVFAPNLPSTSPSPMPSPRIPAHSHASSERRQHLDLLLLSATDGRDTLVDLTRTLAEMAQSHKIRPKDITSNLINTEISATTAITDSGHPKSSKDADAGEPDLVVVFGPYVKLEGYPPWQIRLSEIFCVGDSGGDVSGRTSTRVEYQAFLRGLWKYAGAEMRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8K7</accession>
    <name>A0A0D2A8K7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241318.1">
        <property type="nucleotide sequence ID" value="XM_016376042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8K7"/>
    <dbReference type="STRING" id="91928.A0A0D2A8K7"/>
    <dbReference type="GeneID" id="27328764"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01681"/>
    <dbReference type="HOGENOM" id="CLU_113796_0_0_1"/>
    <dbReference type="OrthoDB" id="5355007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="170" mass="17874" checksum="1B81AA6CB515AB6B" modified="2015-04-29" version="1">MSDTPQIQIPTPTSLTSTSSSLPPETSQALIAHLRATGQISDLSAVLADSLARTGWTDRVRALSLELLRNGTCDTFPELLTEVLRRAKIPNSNTSASSNSTSKVNGTSTPTNGATGGITGNNAIALSKEWSGGPDGLPDVRIPETTVELGVEFLKDKIKDVVEPVEDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8Q1</accession>
    <name>A0A0D2A8Q1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_01732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241368.1">
        <property type="nucleotide sequence ID" value="XM_016376092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8Q1"/>
    <dbReference type="STRING" id="91928.A0A0D2A8Q1"/>
    <dbReference type="GeneID" id="27328815"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01732"/>
    <dbReference type="HOGENOM" id="CLU_653885_0_0_1"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF24">
        <property type="entry name" value="MIP AQUAPORIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW21152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="49168" checksum="94D6ADC1C0D51971" modified="2015-04-29" version="1">MPGDTHAIDVPCTLHFTSGDLMNEFTRPHLQISRPEPTRIGAVPYVTNYSRPQSQHNGQVGSPLSPNFIPSPVSDITLLPSPQDTYNVDVDTTGEQVKVQQPQATALPQQGPRLFRSFGSFDQAHSSEGQDGLPHEYDLLNAWCRFRRRVHRPLAEWLGSTLFMIIGLSGSLVHLTSHESTTDRLGEYLGWGLGVMIGVYVVGGSSGAHLNPIVTIMFTVFRNFPVVTGVQYIVAQLLGSFTASAIVLGLYHDAIDQYDDSTKGTKAGIAFYTSPRPGLSLVTALLTECVGTGILCMVVLALNDPRNIPRRTGMHAVVMALVVTGLCLAFSYNTGTCLNPARDFGPRLLVWAAGVSDSNVWTVNTYWWAWGPWCSTIAGGVIGACIYDLFIFVGPESPVNFPRGYLGNHIRAVREKIAPGKTSTRTCVDVENGELVHVQSSMTTNHDHETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATK7</accession>
    <name>A0A0D2ATK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11956</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230071.1">
        <property type="nucleotide sequence ID" value="XM_016386263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATK7"/>
    <dbReference type="STRING" id="91928.A0A0D2ATK7"/>
    <dbReference type="GeneID" id="27339039"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11956"/>
    <dbReference type="HOGENOM" id="CLU_321321_0_0_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="508"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW09855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="902" mass="102101" checksum="F41E3ED1EDF521BD" modified="2015-04-29" version="1">MLAVAAGHMARGKPRHTLPAVKYYSTALRELNLALSEPAQRSSNSTLGACLLLCVYEISHSDKSLWLQHLRGARDLILYRGGPRTSDFLCRFFSLLDISGSLSSGRGPLIQGNYWLEVDKPSADSSLNQNDLKWPYYDDESVMVNTFHELMVFMASLSKLSAQSMTKFGRQNPHLIYEKAMSIQQGLHDWWRSRPPELRDQDNDWRCLPRAQPLAEPEVLEQESFSSIRSCKDACIIYLQHIINPTGIQPPGSEVSLAAEGILDIASKTPEGYGLEMGLLWGMFMVGVAIFNDTEAEALIRRKLRSDASISIYHADRGLELLEILWERQHRLNLKLDWRELQNEMGVQVTYRLVCLILSNFFETQEHGSIHPLFKAQSDYKAEPDESVTFAGLLPLPIILETIDVYFTYCHNQPYSFFHEESFRSKLSQGKIPDHLLFAILASAVRFSKNSFFKDIFETALFYSNKSWRSIVSTCFSANKVADLATVQTVTLLSILDYTAGRSRHSGAWVKIGLAVRIAQDQKLMLESATDLPLIEQEERRRTFWSIYLLDRLASCGRARPPAILDASCQLQLPSDEESWRAGAWRQTLTLQQLSHRTLSPTNEQGPFGLVVAMAYTLSRGAQYMLQQFNMSNQDPPWDATSDFASIQSDLLYLETILDIHKPPKTIIDQYTRGGRIDQHSTGPIIFARALFHLCYGLLHHPFLLRRRLEFCPIAAPSSFLSRSFEAAWDHSKRMATLFREVRQAGALAQSSFYGYCTVVAGTIAALYLHDPSEARRTEAAAILQMHLSYLEDIGGYWKNVSSMVVALRNFSDAAANFASLSSHSHLLDPLPLEDYETLWILVDYSSMSDETRVERCQASNSNSWLDTDGNWQDIFTVFDSFEVGPQAGNNPTLEMSDYQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AU54</accession>
    <name>A0A0D2AU54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_11761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230201.1">
        <property type="nucleotide sequence ID" value="XM_016386069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AU54"/>
    <dbReference type="GeneID" id="27338844"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11761"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_2_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="492"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW09985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="563" mass="61815" checksum="55088A187AF0A9B2" modified="2015-04-29" version="1">MLSIERILSRPVAKPYRSGKLDPSIAPYLNENGHVDFAPDDVENPKQWSVARRWYITVVAVLMVVNATFASSSPSGSLEGISEHFGVSMEAAGLVITLFLLGYCAGPLVFAPLSEFYGRRVVFLATFTCYNAFNFLCAFAPNFGSLLVGRLLCGTFASAPMTNAPGVVADIWGPIERGNAMAVFSIMTFVGPSLGPVVSGFLELTKDWRWNFYVLLWFGWATELLIFTIPETLPPVVLVNKARRIRATGIPDYAHHKAPVEADDRDLKTLFKIALIRPWQILFDPISFLVAIYLSIVYLLLYMLFTIYPIVFEQKRGWNSGVGELPLIGNIIGSSFGGALIFYISARDKKKLLAGIPRQPEDRLPVAMFGGIGFAITMFWFGWTGQYNSIHWIVPTIAGACLGCMIMLIFVGYINYLTDTYLMYTASAMAANTICRSACGSAAPLFTQYMFNALDVGPGASLIGGVACLLAPIPFIFYKYGRLIRERSKFAPTPLRRPNDEEKQDDVDVTQDTTPNSSSSVSIDSGSGSSVEAPGPERDLRLDAADEKATQGTTNSELPTNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUC5</accession>
    <name>A0A0D2AUC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230281.1">
        <property type="nucleotide sequence ID" value="XM_016386149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUC5"/>
    <dbReference type="STRING" id="91928.A0A0D2AUC5"/>
    <dbReference type="GeneID" id="27338924"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11841"/>
    <dbReference type="HOGENOM" id="CLU_342896_0_0_1"/>
    <dbReference type="OrthoDB" id="10651551at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="826" mass="92195" checksum="1C7976C4239D1233" modified="2015-04-29" version="1">MGNHQSNEVSPDVLKSLKTLGKQLQNCDDESKALGNLVRNFTRAPSTLLEAQPKLLKVLEPIRQRQASDEDIEKFLTTIKHNQNPLSSDQVKQVAPKLRKWRLDDESTTSRLSDASRWIEDPSYFWGAARDARPATSAEVVQKCLQYEKDYLQNDTTLLKLRRRVMREIICLFTTCEKIRTEGNKGGVKLVTDEIATKKKIDDADKKQRQLLHSEVRKRTVAGRRWLRLGRGVSLGVHQNATSFERSPLSEVEIDAARQYCGQLPVFANNTLSTAWFAIVKWFVQDLYETAVRDEVFLYVEKDNSYDKQPNIRKNIKKKDPAAGTTTASNTPEPIDDTDPNTCEQSDDTTSNISEQSDDTASETSEQCDDTAFSTPEQSIDVYEIYHTPSTGHDYHQPKRRRLDGVAPVAIDEQIPDTHSGLRLIQPHSDNSTDLNNFEKNTISETRSAQHPSNTHHECSPSGVNSNESNKTPDVHMDGVTMEVIEDHRPHAGKGDEIWPAAQDLVTNEFCPGNDVPRMPMDFASEQGSLDIHLDQNGNTASSNIPPDQFTSNMTEVSVDNTTLPERPNGLPCRVGEEAPRNKNPPSTEVVESSNIHSREAEAREQIAGTSWTSSNKTTTNGCEDSDSESGEEPHKRRRVGSVSTDTTAEGDRVNLGMSLAHAQKPSEDYADKFTTDEVAADNFTPQMEIHPRSDVVEVVDALRTLAALAPIPLTDCEERSLGDHVGEQDELGPTAQALMSADRRSSAEGEEVDLGIFPDALILGDGAPYQSTDFGRWLDYLEKNNVEDVHLDNEEFCVPESEHDIQDLDIDNWLNLGDGFPNPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUN6</accession>
    <name>A0A0D2AUN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_11176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230431.1">
        <property type="nucleotide sequence ID" value="XM_016385487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUN6"/>
    <dbReference type="STRING" id="91928.A0A0D2AUN6"/>
    <dbReference type="GeneID" id="27338259"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11176"/>
    <dbReference type="HOGENOM" id="CLU_064620_2_1_1"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000063">
        <property type="entry name" value="Synaptobrevin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW10215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="134" mass="14667" checksum="E95165651F339EEF" modified="2015-04-29" version="1">MADREQPYDPYIPSGGQGGAPPAGGNQRTAALQAQIDDTVGVMRENINKVSQRGERLDSLQDKTDNLAVSAQGFRRGANRVRKQMWWKDMKMRMCLIVGIIVLLIVIIVPAGKFLATSDEANNANTCTVVATRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVC3</accession>
    <name>A0A0D2AVC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10 11">Catalase-peroxidase</fullName>
            <shortName evidence="10">CP</shortName>
            <ecNumber evidence="10 11">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">katG</name>
        <name evidence="14" type="ORF">PV08_11368</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 10 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10 11">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="10">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="10 11"/>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230621.1">
        <property type="nucleotide sequence ID" value="XM_016385677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVC3"/>
    <dbReference type="STRING" id="91928.A0A0D2AVC3"/>
    <dbReference type="GeneID" id="27338451"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11368"/>
    <dbReference type="HOGENOM" id="CLU_025424_2_0_1"/>
    <dbReference type="OrthoDB" id="407695at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00649">
        <property type="entry name" value="catalase_peroxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08200">
        <property type="entry name" value="catalase_peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000004">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="5 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 10 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="13">
        <location>
            <begin position="128"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-94)" evidence="10">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW10405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="760" mass="83597" checksum="2DB092F50362436B" modified="2015-04-29" version="1">MAECPVKHDNRRANVAGGGQRNRDWWPEGLRLNILRQNNPASTPLGKDFDYASAFKSLDYDAVKKDLHALMTDSQDWWPADHGHYGGLFIRMAWHSAGTYRVSDGRGGGGAGQQRFAPLNSWPDNVSLDKARRLLWPIKQKYGNKISWADLMLLTGNVALESMGCKTFGFAGGRPDTFEADEAVYWGGETTWLGNDVRYSDGKAGLSEGSHGVVDGDEHKESHKDIHSRDLESPLAAAHMGLIYVNPEGPDGVPDPVAAARDIRTTFGRMAMDDEETVALIAGGHSFGKTHGAAPSDNVGPEPEATAIENQGLGWQNKYGSGKGPDTITSGLEVIWTKTPNKFSNAYLEYLFKFDWELEKSPAGANQWVAKNSGDIIPDAFDPNKKHPARMLTTDLSLRFDPAYEKISRSFLENPDKFHDAFARAWFKLLHRDMGPRSRWLGPEIPSEILLWEDPIPPVDHPLVDESDIASLKKEILATGIDNTKFITTAWASASTYRNSDKRGGANGARIRLAPQKDWEINDKSSLQQVLSALESVQQKFNGSASGGKKVSLADLIVLAGVAALEKASGASVPFTPGRTDASQEQTDVESFAHLEPHHDGFRNYGKSTPRVTTEQFLVDKAHLLNLSPPELTVLVGGLRSLNANWDGSKYGVFTNRPGQLSNDFFVNLLDMSTAWKSTSSDGEYFEGVDRKTGQKKWIATRNDLVFGSQAELRAIAEVYAQPDSAEKFVKDFIAAWDKVMMADRFEVQGSQPGKASARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVY2</accession>
    <name>A0A0D2AVY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase II-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231104.1">
        <property type="nucleotide sequence ID" value="XM_016384502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVY2"/>
    <dbReference type="STRING" id="91928.A0A0D2AVY2"/>
    <dbReference type="GeneID" id="27337270"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10187"/>
    <dbReference type="HOGENOM" id="CLU_031074_1_0_1"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="116"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="278"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW10888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46628" checksum="1E5591C7E68F0DAA" modified="2015-04-29" version="1">MAIPGQRFELNLDAPDFAFTPLEDNAEHDDHSLSAVKEIQEHDTDSVPAAPSLKSSRSGFPEHKRRNVSVFKRNQQASSSRLRPSIPTQVEPSDRAIAHHVSKKYGVDLESQQKADISEENKRRIAEMSIGDIEEARAELMRNLNPAFLERLLKRANIEEDQQEQKQWPQEPGEDHGHDQSDARQDLDLVEDTGVPALPPDGTPSAPSVHFPVPPRSQDDFIPLDPNNPSFFSELRSHYFPDTPHDPSTMTWLQDPTEEETQASLYNPERESFLASALRFGFNGRLIPPKESLEIDVRQGLHHHGDEPSSAGYTIPELAILARSALPNQRCVAYQLLGRILFRLGRGDFGPRGGELQEALWSVIERERPLEVMMAEANRQSGHASTKAHAVEALWLWRKGGGGDRGVLKPGQRFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AW23</accession>
    <name>A0A0D2AW23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231144.1">
        <property type="nucleotide sequence ID" value="XM_016384542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AW23"/>
    <dbReference type="GeneID" id="27337310"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10227"/>
    <dbReference type="HOGENOM" id="CLU_1378143_0_0_1"/>
    <dbReference type="OrthoDB" id="4121173at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="198" mass="20585" checksum="1FF4FC6D3E2B785C" modified="2015-04-29" version="1">MPPNTTSADAAAAAGATSSMPNPQNPTSTAWHLAHAHHASHMPHIHIPTPHPVAATAQFLDKHVPVFAKHHTEFSVNKAARAAKREARHSLVDSPIPEYESDHDQQQHRVSTALRTAAVTTFAPALADGEGLVGSGQVDANEAWMAVLAKREAARLRSGVVGGSDGGSSGSSSDFGARRYPAAAAPQDEQSDDGISGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWC8</accession>
    <name>A0A0D2AWC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231021.1">
        <property type="nucleotide sequence ID" value="XM_016384419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AWC8"/>
    <dbReference type="STRING" id="91928.A0A0D2AWC8"/>
    <dbReference type="GeneID" id="27337187"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10104"/>
    <dbReference type="HOGENOM" id="CLU_000288_125_3_1"/>
    <dbReference type="OrthoDB" id="4133481at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="350"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="683" mass="75801" checksum="5D6F553D51651957" modified="2015-04-29" version="1">MGVELAPVKALLDEIHPSLLGLPDRNSYVLGAIGGHNIVIAVLPEIGNNAASVAATQLINDFPSVRFGLLVGIGGGVPDLPRVDIRLGDIVISKPTKTAGGVIQYDLGKETVHGFERTGTLDKPPPVLRAAVQQLAADHELVDSKVPEYLLQMLGKWPKMKEKYIYPGTESDQLFETTYDHHRGEDCVDCDSSRVIKRRPRSSTNPVVHYGTIGSANRVLKNAAERDKLKNTNLDIICVEMEAAGLMDSFPCLVIRGICDYADSHKNKQWQPYAAAVAAAYMKELLSVIPSRDISSASHASEVTKVPQDQLVSYPVHWTIIRPKNPLFTGREELLSELEDIAHRTVKNTKRQDPSCIVISGMGGQGKSEICIQLAHRIRHLFWGIFWVDVSTPSLAETGFLSIASRLQTGAQTWKGALQSLSNCKEPWFLILDNADDVDVDYQQYFPSTALGLVLLTSRNAECREYATQKWIDLEGLPMAQARELLLRAASIPRNRHEMLDADARAVTSLLQSHPLALIQAGAYVSRGHCVLKDYPKEYQRQRERLMRFRPSQARSRYGDVYATFEASAEILQSTNTESAHDSLQLLDVMASLGSSRLPLQLFEAGWNEAQKISSDHVDEEKLSRLTMWHADHLLPLISADREHWDSFRLIEAINLLKAFSLLATDTADGAMTSISMHPLIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXB3</accession>
    <name>A0A0D2AXB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YbgI/family dinuclear metal center protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_10334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231251.1">
        <property type="nucleotide sequence ID" value="XM_016384649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXB3"/>
    <dbReference type="STRING" id="91928.A0A0D2AXB3"/>
    <dbReference type="GeneID" id="27337417"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10334"/>
    <dbReference type="HOGENOM" id="CLU_037423_0_1_1"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="445" mass="48249" checksum="CE9900420B2C3D0B" modified="2015-04-29" version="1">MNTSTSYNVSPFTSAVVSSMRRLYPESLADKSFDNTGFLVQAPFLPARPRNRNSVLLTVDLTRAVADEAIENGASVVVAYHPIIFRGLKSITTDDTQQLSMTLLLAHGISVYCPHTAVDTVPDGMADWLCDIVTGKTDVPEDHAYTATYSSSVPSETEVTTTDEDDDANEDSDAAQSHASTKPTSPSAADHDDPFTSTDTPKPNKKLRLFRPHSHRTYSKPTYPRPTEDFQPAVLPHSRSVITPSPRGALDEANRFVASDTDIYHPNNTGAGRLIEFAEPQPLTVLITRIAHAIGLPKGFAIAVPQGKTLEEIAIASVATCPGSGGSVVRGCRADLVFTGELSHHEALAVTERGGCVISLFHTNSERGYLWTVMREKLENEVRDEWARVRSEEGAKIGLDGEIKEMLQDESVEVVVSERDRDPYGIVVLEETAVEGVRIGSGSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXI0</accession>
    <name>A0A0D2AXI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231366.1">
        <property type="nucleotide sequence ID" value="XM_016384764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXI0"/>
    <dbReference type="STRING" id="91928.A0A0D2AXI0"/>
    <dbReference type="GeneID" id="27337533"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10450"/>
    <dbReference type="HOGENOM" id="CLU_2096903_0_0_1"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="116" mass="13402" checksum="85CCFFFAF1FF333B" modified="2015-04-29" version="1">MAPFIARLQYLTTRKLWPFSLAPLSQSLRRDVPYPKLQAMRRTVERSSHDRHTNPGGTIRVSKGKRENDVVIQELSHPVSEAKKRRILLREDPIAVDNFKDFDAAISYQCGDGMYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZE6</accession>
    <name>A0A0D2AZE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232254.1">
        <property type="nucleotide sequence ID" value="XM_016383631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZE6"/>
    <dbReference type="STRING" id="91928.A0A0D2AZE6"/>
    <dbReference type="GeneID" id="27336395"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09312"/>
    <dbReference type="HOGENOM" id="CLU_079101_0_0_1"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="89"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="259" mass="29472" checksum="04061748B45EABAC" modified="2015-04-29" version="1">MKLLTKEQEREHYRQTLKGGAIGGTLGLAVGTAGVLLAQRRYHFFRNLTLPLKAFLVTSAGTFAGIVNADSYSRAYEIQSNPIDVEFHARQAEREKAERANKTFTERAMDFGRRERYKIVAGSWIASMGIAFAMVNRNKYLTGAQKIVQARVYAQFLTLGVLVATAAFEISDSRNSQGRWETVRYIDPSDPEHKRMLEKQVERDAPSQGGVGNPNDDLWKEMVAAEEERIKEREARHKEHAAREHHKKKNGHEENKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1S2</accession>
    <name>A0A0D2B1S2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription initiation protein SPT3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232771.1">
        <property type="nucleotide sequence ID" value="XM_016384148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1S2"/>
    <dbReference type="STRING" id="91928.A0A0D2B1S2"/>
    <dbReference type="GeneID" id="27336915"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09832"/>
    <dbReference type="HOGENOM" id="CLU_038706_1_1_1"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40816" checksum="C111E66B9EDC6DB4" modified="2015-04-29" version="1">MASDHSKTLDSDTMTEYSRPGPRLVDPPDYDQIDIETMDEFKDRLIYWVEQMMFVSGETTEPSAETTWMIEEIVREQVVEMLTQATALANRRGSKSISIIDLIFQIRHDRAKVSRLKTFLSWKDVRKNVKDSDDKGGGDAGDVGDFDEAAGGVNPSAPQKTSANKKARLVLPWEVQSFYAEQVPEREDEEDEEEEEQNEATLARLASADERTKNMTKEEYVYWSDCRQASFTFRKGKRFREWAGFGTVIDSKPNDDVVDVLGFLTFEVVQTITEEALKVKAIEDQANKKASGGRGDQEALKKRKRAGCSLFEMPEEGRTPVEPKHVREAFRRLQVVPNKYKFMRRGYAGMRTPLRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2S0</accession>
    <name>A0A0D2B2S0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="11">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="11">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="11">PHB:PPT</shortName>
            <shortName evidence="11">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_08415</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
            <orientation evidence="2 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="11"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233444.1">
        <property type="nucleotide sequence ID" value="XM_016382741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2S0"/>
    <dbReference type="STRING" id="91928.A0A0D2B2S0"/>
    <dbReference type="GeneID" id="27335498"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08415"/>
    <dbReference type="HOGENOM" id="CLU_034879_2_0_1"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW13228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="359" mass="39049" checksum="A166726654BD55DE" modified="2015-04-29" version="1">MVIDDVFTKLAKSTGTTEPPVKPLPIHELPTTYRPPTTGFISKLPASWIPYAELIRLDKPAGTYYLFFPCLFSTLLAAPMAAPMATPVEVLTTTALFFSGALIMRGAGCTINDLWDRNLDPYVERTRMRPIARRAISVENAIVYLGAQLFTGLAILLQFPLPCLYYAVPSLLLVTTYPLAKRVTHYPQFVLGLTFSWGAIMGFPALGIDLVSNPSAVAAAAALYSSCVSWTLVYDMIYAYMDIKDDAKAGIKSIAQAHEHNAKAALSVFSATQVGLLVAAGYFAGAGPVFFVGSCGGAALTLATMIRRVNIKDVKDCWWWFKNGAWLTGGVVSFGLLGDYLYRRTREEPSTVVHHAVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3Z8</accession>
    <name>A0A0D2B3Z8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233626.1">
        <property type="nucleotide sequence ID" value="XM_016382923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3Z8"/>
    <dbReference type="STRING" id="91928.A0A0D2B3Z8"/>
    <dbReference type="GeneID" id="27335681"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08598"/>
    <dbReference type="HOGENOM" id="CLU_460790_0_0_1"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="58871" checksum="1FEC20842E7911A3" modified="2015-04-29" version="1">MFVTLADHEALATRAGTATRSLRAHVQHNYLSRQQKGRDGPSVRPDDPQAKPAVMRFRWGKRKQVKNDNNKNSSGLASSDEKLSRDDRHNLMLRLLKPRSTDAMFSPSRGEGVDPFGVLPFHVHEQERLTLQGFQSHERWPWCPINGKSAWSRFTVSDELVFHTTMFSWTMHMRSRGEDATPMSNVLSHKVRAISIIKQRVTQPKLSTSDEVIGAIAALTNIELVLGSQADAYTHLQGLRAVIAARGGFTTLNSPEQQLILRLATWNYLVYSEVFGDELRSEELQWWEEAWQTTFASAAIKPLPGLSSQELSVAQVPPHQVFTLLQYLPHLCSLESQKPLTSLSDREAMHRCDIFHRLQWRLKRIIDGIKSSATSPGAMRVRAVATAILVYVHHHLRGNPLSYRNYSVLLPMLIHDLDALETLSKDLSFAPELYLWILSIGSTTSSRLAEVHGRFLTKLSNLIKNQNMDRAAFLKKHREFLWIKAKDEKRLADIWDRLWCLHIEHEHIEAQDPSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B567</accession>
    <name>A0A0D2B567_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234219.1">
        <property type="nucleotide sequence ID" value="XM_016381117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B567"/>
    <dbReference type="STRING" id="91928.A0A0D2B567"/>
    <dbReference type="GeneID" id="27333867"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06784"/>
    <dbReference type="HOGENOM" id="CLU_073661_0_3_1"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW14003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="210" mass="22127" checksum="BEA5DA0920DA90AD" modified="2015-04-29" version="1">MAEKAPPSLAAVAVSSLLLGLLAGYFIGQGSSIGVFGGSSTSGGVKKSWPNSYDVKVHADSSDEQADDEDEDEEEDEDGGDGNELRDFRDSKEEVKLVLAVRTDLGMGKGKIAAQCSHATLACYKYLVNHPSSAPLLKRWEWGGQPKIAVQAKSEEELETLQAQAMSLGLCARIIHDAGRTQIAAGSATVLGVLGPKSVVDQVTGQLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B580</accession>
    <name>A0A0D2B580_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234249.1">
        <property type="nucleotide sequence ID" value="XM_016381147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B580"/>
    <dbReference type="GeneID" id="27333897"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06814"/>
    <dbReference type="HOGENOM" id="CLU_041955_0_0_1"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="461" mass="50869" checksum="16E1B75E0B43899B" modified="2015-04-29" version="1">MPPKRIRTVEGSCWACKQRRVKCSLEKPACRKCIIGGTKCSYDKILIKWDARPSKGSPVGNQLCLYHNSLPGSSGYNLAINERRAIDYFRSRVWPLFSTSAQPCPPPIALAMADRSVLLATCVMADSHRVLFDGRHSKENVHNKRMHCITTVRKQLADAADSKGMPLSTVLVAVLLMYFSDGFVECRQPDSSTLSHHAGARAIINSLGGFSAIMSDGDTSVKMLLSEFATTDLTNSLLHGTPPSFPAHTWGIMDTSAVWWEKTPSGMESFASIFQKLSELAAFHDLVSLGKQELSVQRIKEFEADLRPGYASISPVELTDIKEEGEDRKSLDPDLVPSAALLRAFQHSANLYLYRAVCGLPANHYVVQQHAQACLDCIMGMPPQSKALNCALFPLLVSGAHAFTDTSRQAILQKLDVVYSNLKFNAVKSIRSALEDLWKSSRQGGSWFDMFIRLDAQALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5Z8</accession>
    <name>A0A0D2B5Z8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_06876</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234311.1">
        <property type="nucleotide sequence ID" value="XM_016381209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5Z8"/>
    <dbReference type="STRING" id="91928.A0A0D2B5Z8"/>
    <dbReference type="GeneID" id="27333959"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06876"/>
    <dbReference type="HOGENOM" id="CLU_037146_1_1_1"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW14095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="444" mass="48909" checksum="35535B8ADAA7E0EB" modified="2015-04-29" version="1">MDEPPMPGAFPSTAEERGNTNRTPKRRFVGRRTADAQARQRQDANGSVEETAAIVVKSQRKTPRALNQIPAEILDDPDIQAAIALLPHNYSFEIPKTIHRIRTLEAKRVALQFPEGLLMFATTISDILTQFCPGTETLIMGDVTYGACCIDDYTARALGCDLLVHYAHSCLIPVSATKIATLYIFVDISIDTKHLVSTLSRNISPGKTIAMVGTIQFHATLHTIRPALEAEGLKLVVPQVMPLSKGEVLGCTAPKIAKDQNVDLILYLGDGRFHLEAAMIANPDIPAYRYDPYSRKLTRETYSHEEMLDMRSSAIGVAKKAKKWGLILGALGRQGNPHTLTMIQNYLTQQGIPYINLLLSEIFPGKLALFEDVDCWVQIACPRLSIDWGYAFPRPLLTPYEALVVLGGQQGWDRGDGTYPMDFYANNGLGRTTEKLAAQVAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B651</accession>
    <name>A0A0D2B651_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA (Uridine(2843)-N(3))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234589.1">
        <property type="nucleotide sequence ID" value="XM_016381487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B651"/>
    <dbReference type="STRING" id="91928.A0A0D2B651"/>
    <dbReference type="GeneID" id="27334238"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07155"/>
    <dbReference type="HOGENOM" id="CLU_028833_1_0_1"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38281" checksum="27ADDAA4DE78730A" modified="2015-04-29" version="1">MAPPGRKQKGSSGTKPTHISREPVNDIIAQKRPEAAALPVELQQMILDVFRRAFPLHDQGEVKTVIQEVKGHLFQRDFASAFAKQEYLDAYALRWSAARSLGYTDIFLHRDLQPVWVGGTDPCLDMNSSPSSMRVACIGGGGGAEVAACAAAVAQTHSLSSLEVHAIDIADWSGCLDKLAHHLCTPPPLSAYASESAKSANGPLVASGQFSHCFSQCDILAVDEGRLRDLLAPVRLCTVMFTLNELFSSSISRTTAFLLAISDMMQPGSWFLVVDSPGSYSEVKLGQGQTKKYPMKWLLDHALQDVAQGKWKKQVSDDSRWFRLNSSLKYPVELENMRYQIHLYQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6M9</accession>
    <name>A0A0D2B6M9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234556.1">
        <property type="nucleotide sequence ID" value="XM_016381454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6M9"/>
    <dbReference type="STRING" id="91928.A0A0D2B6M9"/>
    <dbReference type="GeneID" id="27334205"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07122"/>
    <dbReference type="HOGENOM" id="CLU_162804_1_0_1"/>
    <dbReference type="OrthoDB" id="2279190at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="101" mass="10098" checksum="86F41571EA0C35A5" modified="2015-04-29" version="1">MSAATPAYGKNADIGYSSGSDDGQAAGQRKALATTSGSGAALPLPPTSDSLSQPAGSLLKGATDENGNLKPAALMLGLKLDLEAEVHLTARVRGDITIGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6T9</accession>
    <name>A0A0D2B6T9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_07397</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234829.1">
        <property type="nucleotide sequence ID" value="XM_016381727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6T9"/>
    <dbReference type="STRING" id="91928.A0A0D2B6T9"/>
    <dbReference type="GeneID" id="27334480"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07397"/>
    <dbReference type="HOGENOM" id="CLU_048136_0_0_1"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249538" description="Peptidase S26 domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="10">
        <location>
            <begin position="103"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW14613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="403" mass="45265" checksum="81FC8921A1AB4DF2" modified="2015-04-29" version="1">MPPTSRGAFLVLRLIRHASSASTINTRTAHTRTLPPLPSLPTPKRTPQFKTPSRIHAESQPSNPRPSIFQVLRSPTTRRLVWYLVFVVPPVAFFLSQFPLRIATVRGPSMQPYLNPTHSPDLPEPAPDRILLQKVTFPGRPSVVFNNPPFQLHRGQIVIFYAPHDPKKWAIKRIVAVPGDRVTPRPSYPGGDGPVVVPYNHIWVEGDADGRDKTVDSNWYGPISQNLVIGVAKAAWTPWSWPWQWRGLGNWTDHDYPAKRQGRVEEDVVGEAKVDPDKVHMGQAFADGTAARELIALQAKRQRLPEMMADRKKLDKLRTIYTYAKLELEENNPESVDVAQALVDELETAFKSVGLHEDGSEIPPIPYAIQEEESKRKEFEKYLDKQRAKGAISASSPTDLSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7Z4</accession>
    <name>A0A0D2B7Z4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235016.1">
        <property type="nucleotide sequence ID" value="XM_016381914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7Z4"/>
    <dbReference type="GeneID" id="27334668"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07585"/>
    <dbReference type="HOGENOM" id="CLU_081916_0_0_1"/>
    <dbReference type="OrthoDB" id="4500473at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="289" mass="32150" checksum="CD35890A5B96B1B2" modified="2015-04-29" version="1">MEKVWFKLRQPDYRPEDDDSMGTSKETSPLCLGHFISDLKNLDFPLNRGEIEEFPVNMKVYQSSTLHFQWKDSQEAQTGGGLGAGAPIAAAMGLVIKASAQALFRHEVEHWEEYDQLDTYIVQPDRIYVSECLEGNKLANYIKDKKSWSMFMVTGVKVARKGKMTTSKSRHSEASGELEGDVPTVASAKGNITVARGKSEQFGGSVISDFIWAVRLAKISKGILMKDWSLAPYTKRATMDTGDEEQVDLVGTVAAEGLGSFRVIEDAELDEAFVLDDEPLPPEEERETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B862</accession>
    <name>A0A0D2B862_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Frequency clock protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235294.1">
        <property type="nucleotide sequence ID" value="XM_016382192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B862"/>
    <dbReference type="STRING" id="91928.A0A0D2B862"/>
    <dbReference type="GeneID" id="27334948"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07865"/>
    <dbReference type="HOGENOM" id="CLU_007103_1_0_1"/>
    <dbReference type="OrthoDB" id="2536795at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018554">
        <property type="entry name" value="FRQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09421">
        <property type="entry name" value="FRQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="830" mass="90530" checksum="EE813FDEF5B9A039" modified="2015-04-29" version="1">MAQQRSYHAPGPLQSQGEAAFGQQGQDESERDELRGVIDDLTVENKRLKNILKTWQSRSSPKSSQGPDRIIEVRMHGLPAERKRELEQILKTFAHGLNDGDSTSQPGSSLPMEKSLPSTEKSLPTGQRPDQTNTDSGYASISGSGLNSSTGAAALSEPLSKRKKAKDIKNYLHDIPDSLFPQDTMSVSESARMNLVVQRLEQLFTGNRAKPGEHSLPVQQQKISRAAAKADRAENRRQNRENKVEGSREARVLPPESKINFDSAELELPQTRTQGQNGKSGVSASDSPASTDRPGSPNQRPTRPLDLDIHRAQVAEDNIKYLRHLGLASPQFGSSPGQEQPWLYLNLLSSMAQLHTLNVTPAFVRKAIKQRSTMFELSKDGHRIRWKGDAMAPVWPDTQVSPASAEPRGSEDMTDEGGRHSVRGSNTSTVNEPSMSLSDDKKQRKLSTVGSKLVTSVGTSSNLALNQTSSKSISSAFDYKPIVFKGKRNPLKAGHSYLDSSSSNGEFSPDDSDLAQALSRSSLKSKDESREGLMTFFSNPYYCTDLSGDRSPVNLRSLDPEDSREVLGLAKAHQPGDSIIRDINACYYTARADPALRAWPTECPDVEMVFKPIEASGEDETQPLEFEASGIGGVRPEDNFALDVKIARTRFRDGGRKEKGKGKARRGIHGQAEYSYRLEKCTQLTLQPSRLPPPSYVFHTSSSSSAEKGHFYDDDSDSDAPDDDFSPGPGGLMWRWSSESNEHLIVDEGSDASSSMGRLEASRTRLGNPGAGARANHDFIIHPSGGTMSGSLAATVGASWSAKSNVEQEPEPAVEEDETSSEMSTDEGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9D4</accession>
    <name>A0A0D2B9D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235734.1">
        <property type="nucleotide sequence ID" value="XM_016379907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9D4"/>
    <dbReference type="STRING" id="91928.A0A0D2B9D4"/>
    <dbReference type="GeneID" id="27332647"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05564"/>
    <dbReference type="HOGENOM" id="CLU_034311_2_0_1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF26">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G13940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249605" description="FAD dependent oxidoreductase domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="50"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW15518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="353" mass="38368" checksum="4156778AD645890B" modified="2015-04-29" version="1">MAQGGKSIVVIGAGIIGLTSALQLQSALGSNSSITIVARDWPSDENVHYTSPWAGAHGRPFPATSALEIQQQELSKVTDAVLRSQATSEPACGVVFMDGYDYLSCPSEAYTHLRGGYGDAEGLQVLPKQELPKGTNITFGTRYRTWSLNPPVYCAYLLRKFQLRGGKTLRRSLTCAEEAFSLASNVDTVVNCSGFGFGDPAFFPIRGQTCLVSNPCDRTINQLNADGTWTFIIPRPLEGGTIIGGTRESHDWTEHPRPETRERVLALAAKMYPPILGRDGKFHVIRDIVGRRPARISGFRLEAEYMKGPHLKGRKIIHAYGAEGFGYAISWGVAQKVLDLACGGHDSVARPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEC2</accession>
    <name>A0A0D2BEC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_04535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237559.1">
        <property type="nucleotide sequence ID" value="XM_016378882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEC2"/>
    <dbReference type="STRING" id="91928.A0A0D2BEC2"/>
    <dbReference type="GeneID" id="27331618"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04535"/>
    <dbReference type="HOGENOM" id="CLU_031804_1_0_1"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112395" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="21"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="316"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW17343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="474" mass="52605" checksum="C5049A99CA0DC10A" modified="2015-04-29" version="1">MRLLKSLSLLLVACVGVVSAKSAVGNRVLVVLEDQALKGLYSKFWADLEARDFQLTFESPRKDDVSLFRHGQLAYEHILLTPPKSKGYGPALTPKILLDYVNAGGNVLLGLSSESGTPSAISALLLEFDISLPTDKTSVVVDHFNYDTVSAAEKHDVLLLNRPGPLRSDTVNFFGGDGVLAVPRAVGQTLGNTSPLIAPILKAPATAYAYNPKEAAESLEDPFATGSQLSLITAMQARNSARFVVLGSLEMLQDKWFDASVKSSSSSGKNVKTVNQEFARQLTEWAFQEVGVLKVLSVQHQEIFSSKTEITGYGDSNPEIYRIKNDVRYSIEISQYARDHWEPFTVPANDDLQLEFSMLSPFHRIPLSPTATTLNSTVFSTTFTTPDQHGIFAFKVNYKRPFLTPIEEKNQVTVRHFAHDEWPRSWAISGAWPWIGGLWSVIVGFICFTVLWLYCEPPKEELERRRRLSVSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEP3</accession>
    <name>A0A0D2BEP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">medium-chain acyl-CoA ligase</fullName>
            <ecNumber evidence="5">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_11955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:48341"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="5"/>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230070.1">
        <property type="nucleotide sequence ID" value="XM_016386262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEP3"/>
    <dbReference type="STRING" id="91928.A0A0D2BEP3"/>
    <dbReference type="GeneID" id="27339038"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11955"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_10_1"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051087">
        <property type="entry name" value="Mitochondrial_ACSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605:SF10">
        <property type="entry name" value="ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605">
        <property type="entry name" value="ACYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="494"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW09854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="596" mass="64839" checksum="D210733FDE15113A" modified="2015-04-29" version="1">MVPFTTDNVFSPPPSFNFATDVVDGWARKDPSLLALQWIDDDVSKPLSFTYEHFSRQSCKAARLLLALGAKPGDRVMIILNRVPAWWEIATAVLRAGLVLCPCTTLATTKDIEYRLQTSGASILIGNEESLRKVANLRSSCPDLRVVLQASGDSIPGVPQYSTEVERHSSEHLVGVRTRADDPALIYFTSGTTGLPKMVVHTHVSYPLAHLLTGIHWLNLSAGKLAWTLAEQGWAKAAWSWFSTWNTGATLFVQDSNKPFSPTSTLDVLHKFPITTFCAPPTAYRQLVTAQSQAHFATHRPRALQTCVGAGEPLNPGVIEAWKEMAGIEIRDGYGQTETILVAGNCAGVQTRVGSMGKAIPGIPLHVIDEDGGIADAGVEGDLAVLAVDENGAQSAFIYKGYVSSKGELSRKSRPRRDANGAVSGEWHLSGDRAYQDGDGYFWFVGRSDDVINSSGYRIGKGVSPSHALQDSTQYVAYSQLPWLTFVDATGPFEVESTLKLHPAVVESAVVGVPDAARGEIVKAYVVLDPSFASRDHASLARELQEHCKREAAPYKYPRSIQFVAPHWLPKTTSGKIRRGEIRKWEKAAAASSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BER3</accession>
    <name>A0A0D2BER3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230085.1">
        <property type="nucleotide sequence ID" value="XM_016386277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BER3"/>
    <dbReference type="STRING" id="91928.A0A0D2BER3"/>
    <dbReference type="GeneID" id="27339053"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11970"/>
    <dbReference type="HOGENOM" id="CLU_000688_8_4_1"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="206"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="552"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW09869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="790" mass="85182" checksum="C15DC2828A73B48B" modified="2015-04-29" version="1">MAPGGHRRTTLSQGLDREVYQVVRKILDERSQYGDSDTRLSFSTIYDDIKRSNSSLNRKPKKLLEDSIERVLETIQQDAKDDSDEFMPVETPAEAQRLKVSSGLNRSIVGAWSKSTEGLMSPKRATDSEGAAPMETTSSKRLTNGEPPAKRRKARDGPRETIDHSAPTYINLASLGGVDNVIQQFEDLLVLPMTRPEIYTSSKVQPPRGVLIHGPPGCGKTMIANAFAAELGVNFISISAPSIVSGMSGESEKALREHFEEAKRCAPCLVFIDEIDAITPKRESAQREMEKRIVAQLLTCMDDLALEKTDGKPVIVLAATNRPDALDPALRRGGRFDKEINMTVPSEPVREQILRALTRETNLSSDVDFSILAKRTPGFVGADLNDLVSTAGAAAIKRQLTMIKAHAESSSMAVDMPTDHPDSNISPVLASLRRLIKYTSATASRHPLSAAPASTEATTTTTTTTTTTTTGNTNSNGDDAGADESVVHVTMADFLAALPKIQPSALREGFATVPSTTFASIGALSRHISELDMTVISPILTPAKYANLGITPSSGTLLWGPPGCGKTLLAKACANSSHANFISVKGPELLNKYVGESERAVRQVFARARSSVPVIIFFDELDALAPRRDGTSSEASARVTNTLLAELDGVGSERDGIYVIAATNRPDMIDPAMLRPGRLETLLFVGLPDAEGRVDILRTLCRKIPNFVFGEDVAAIARLCQGFSGADLKALLQRAGLMAISRCTALGLPPEDITLTTADFERAMAEVRPSVGVDDYERYTILQKDFGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFF8</accession>
    <name>A0A0D2BFF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230285.1">
        <property type="nucleotide sequence ID" value="XM_016386153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFF8"/>
    <dbReference type="GeneID" id="27338928"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11845"/>
    <dbReference type="HOGENOM" id="CLU_1204780_0_0_1"/>
    <dbReference type="OrthoDB" id="4124716at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="230" mass="26510" checksum="F7DE8374B38BEDB7" modified="2015-04-29" version="1">MKENVMKDSEKSIEGLRHSIQTLLSSFEMPSEEQPLSLIFHSSNETPMVQIHDSKWLVEFKEVLKSDDQIVHESQVPLESAVLALYHWASRNSGPSEEHERIIEMLDKLRERLMYCAIIARIDGDEERYFELFPTACLGEGIVLPARLIDEMIIQPAKLRGEVIFSPAPTVKVHGHLCEWHTRERRCVVSYDGHMLKLDGKLLKDGPLVLCGETGKLHQRLLRRYFAQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHB2</accession>
    <name>A0A0D2BHB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_10038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230955.1">
        <property type="nucleotide sequence ID" value="XM_016384353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHB2"/>
    <dbReference type="GeneID" id="27337121"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10038"/>
    <dbReference type="HOGENOM" id="CLU_956546_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="291" mass="33468" checksum="D6FDC2FBCB244CD9" modified="2015-04-29" version="1">MPQNLHWVSYNGDTGRKDSQQRSQINSFLNRTKSRQKYERLRLGPSLAVNWEAGRSRYGHDEQPSLPPKTSPENVLPLGIWRQELPKSTRATSNRHRSKDNDHKSTAIVSIENHYITSNPVEPFGAMAVEIKPEWYTGLEYWIYGFDPAICRQQRVAGIYSASRAGHFALRFRNEALFHATMAVAYNSFDNLSHSYDAQAPSIRVLYHRGKALSSLSAQLTSMQIKSSVIFQTILNLMVVDSTWLDFDSLSKHQVGLRSLERLELEDPVWSKILKRLMETYMPNVLWIENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHD4</accession>
    <name>A0A0D2BHD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238604.1">
        <property type="nucleotide sequence ID" value="XM_016377034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHD4"/>
    <dbReference type="STRING" id="91928.A0A0D2BHD4"/>
    <dbReference type="GeneID" id="27329759"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02676"/>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="271" mass="30021" checksum="38C5A150DE144151" modified="2015-04-29" version="1">MVNGDFHNCTDVSPGCPISGTTYGYIPNIPANYALVVVFGTCAFLQLALGIFFRTWTFMIAITAGCLMEVIGYIGRIELHHNVWSRAAFTQQIVCLIMAPSLIAAGIYLSLKHIIIYRGPQHSRLKPRLYTWVFIGCDAFSILVQAAGGALAGTAKNDNPSLMKAGNTTIMAGIGIQVATMTMCSILVLDFAITYRKRAECPRKTTSFSHTRFRLFYFAEIFAFVTVLIRSIYRLPEMAGGWGNQLMRNETEFLILDGMSLLSIDERSAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHL0</accession>
    <name>A0A0D2BHL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_02382</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238311.1">
        <property type="nucleotide sequence ID" value="XM_016376741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHL0"/>
    <dbReference type="STRING" id="91928.A0A0D2BHL0"/>
    <dbReference type="GeneID" id="27329465"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02382"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000119">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000152">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="138"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="243"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW18095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="36733" checksum="0B018378295F5E8E" modified="2015-04-29" version="1">MSQSKNIAPTPTEGDLDRASSSSAPANSPSAVSAAQQSDNIAHALAGAGGGLLAMTLTYPLITLSTRAQVESKRADTSTLAAVRHIINREGVSGLYAGLDSALFGISVTNFVYYYWYEWTRSSFEKAALKAGRASKKLTTVESMIAGAIAGSATVLLTNPIWVINTRMTARKNEDGEGELPGGEKKPTKAPSTIGTLLKLLKEEGPRALFAGVLPALVLVINPILQYTIYEQLKNVLEKKRKVGPRDAFYLGALGKLLATTITYPYITVKSRAHVATKDQPHEGMWKSLNKIVKDEGWGGLYKGIAPKVSQSVLTAAFLFAFKDVLYDMTVAARRKARAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BID9</accession>
    <name>A0A0D2BID9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238939.1">
        <property type="nucleotide sequence ID" value="XM_016377369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BID9"/>
    <dbReference type="STRING" id="91928.A0A0D2BID9"/>
    <dbReference type="GeneID" id="27330095"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03012"/>
    <dbReference type="HOGENOM" id="CLU_014921_1_0_1"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="199"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW18723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="676" mass="75805" checksum="87A3241FB750CD8D" modified="2015-04-29" version="1">MASSEPGLKRTTLACNPCRQGKRKVSGRFLQDQIQRAQRAHSVMARKYWDEEYVKLLEERISFLEGLTEEDSVHGKGSEQLHDHLVNPRNDRISYTSRTGEDDGFTTLYNSGGLLDEENLVVFGPRPRDAAIDELSAVIWKLDINSEGFTGPSGNLCVPGITSGDKAPDLNPTSQVQLASSPVNLSEAPCPPDWDHFSHIFLRFVNPIFHFFEKTSLDQSIARAPSHSLGQLLRCAVVLAAALYSDQPGVELTVQNCVAVTERLSLVCARDTPSEHLVTAFSILALRELSVRNANMGWMYNSMAAATVNQLGLHATNLTASGTLTASEVSLAASDRARAFWSFFLIDRIATTILGRNCTIPRKRISSTFPTNMGQQSSEAEDLAFQYQCRLWDIHDRYMDQIYIYDFQTIPKKKKIALLNEAESVLLEFRRNLDPSWTPTRTRHDSGSLILQMSYNMSQLLIHRPYINNEFKSDAVYMSAMTTVSLAAATITRLLAMYMKTFAISTAPFFICHHILSAGMIHLMNGTAKDESISRRSSKRLKICFVALEQLRRTYPEHAKSSISALVRLAERWQLLSLIPINYSNASLLKESSPHLVKQPEGAEDQTRIRVSVESTPTDRFDIYFDDAFRGSEGLGSWRDMGAEASHVLSSHNYDVEDFAKIEGLEGFDLFDWSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIP1</accession>
    <name>A0A0D2BIP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MIND kinetochore complex component Mtw1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_03092</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239019.1">
        <property type="nucleotide sequence ID" value="XM_016377449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIP1"/>
    <dbReference type="GeneID" id="27330175"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03092"/>
    <dbReference type="HOGENOM" id="CLU_046437_1_0_1"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34190" checksum="6AF068F3B3F07C3B" modified="2015-04-29" version="1">MADSSQAATSLLTEHLQYTPLSLIDDIINSVNNFVYQGVGSLETGLLSTPPEKLGFKATTATGADGTEENEFPEAKQEIEEGLHKLETLLNSTVDKNFDKFEIYVLRNILSVPAELVNWVRLSHYQNITYPLPETSPTVEDIQLLRRKLAASRALSQNLHREHSQNQAMLKQLRALIGGVQQEANTMSFLTQSPAAQALNLAGNPDKQLLTTNTKFAVSQLPALRSLLDDLRPKLNALKSLECNASRASAKEEIKEERRGYIEQRTRSHLERNGINPAENSSLLFAKRVDEEEVHALEKVASIFDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ99</accession>
    <name>A0A0D2BJ99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238876.1">
        <property type="nucleotide sequence ID" value="XM_016377306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ99"/>
    <dbReference type="GeneID" id="27330032"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02949"/>
    <dbReference type="HOGENOM" id="CLU_411043_0_0_1"/>
    <dbReference type="OrthoDB" id="3647246at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055528">
        <property type="entry name" value="DUF7102"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057559">
        <property type="entry name" value="SAM_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23394">
        <property type="entry name" value="DUF7102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23395">
        <property type="entry name" value="SAM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7102" evidence="2">
        <location>
            <begin position="420"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-like" evidence="3">
        <location>
            <begin position="587"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="668" mass="75116" checksum="EA71D2810CB9D52B" modified="2015-04-29" version="1">MESAFTSPSPESCPPRRSRLEAKDEMDIDDPVSKADKNLDSDDADKDTAEHHAISHTEELRVEDSLKMEEHGFNGATPSYRLKLDSRINVCRYSMDSTPNPGPQCIRTSSSAKSSHPKLRLQAKSLKASVPDLQPAWLQYAARRIMQNETLEELLNKPSGVPPVAPTLEDNSCSNWQPFDMTMFQDTLREAIDDARSLSGILEPSANIMLSKQMLWKRPGLLLQESGDYSDFRMDVDNELNQETPVEFLSQVPQKRIALDSIHDVRPPMKRLLLDLETRPTTPPRRHFKPNRGRLKELIESQVGIPSSSVTMAAQNEVDTHGASRFSAANSLRTFLDLRGNKFKKTSFVEDSDKQQISDDPIRSTSSESSDSIKISLQTEIRAVPREQVPGTLMLASLTDMANMFLKNDMLTFEKFDPPRSIIVNTGMLRKDRCLITSLETHAEDSLSMIYRDMDSPDVILNPRACLVFTNLQALSQRSLPGQQGSAKEGLVQSIVSRLVRDFEITFVFVAMPDTGGSVSRNVQDAMNNFTGFCMTKSDRDANVCPIWVLTNTETNDTGDDLQSWVWRLIHQHAFVTAQLNDFAFIHEESIGELFFQRLGLNPMAAQVALHVLESPETTSAQVSRSWGLRELARLRTEGRMDLLREVLGLKTVRKLTSVLETTQYHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKB0</accession>
    <name>A0A0D2BKB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239211.1">
        <property type="nucleotide sequence ID" value="XM_016377641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKB0"/>
    <dbReference type="STRING" id="91928.A0A0D2BKB0"/>
    <dbReference type="GeneID" id="27330368"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03285"/>
    <dbReference type="HOGENOM" id="CLU_033731_0_0_1"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="549" mass="60005" checksum="0AD5CC2BFA19FCF2" modified="2015-04-29" version="1">MARHVDDPTTINAFLRLIHGTPLSASPNARAEPQTVPLATLNPTSHESGDGIASPESWVSPDGASVSAETSPARGSRAPPPTPETQPVSNGISTPLEPIFEDASDWSSGTKQTPVNMNNPECCEGDSSPPNHGSLVKDDLIPMTEDLTSTQNALLVKRQPHTAGEDQDEIRRKLRERAACYMEETVEKFRQSKAAMFVEGERQAVQETSRVAEVNTTRIQDTRMTGTVQTSKLAKTPEMPVSMTGLHSLADDSPIHRMQNPATKNEAMPTAQENEIVKERIHNSDESPFSASTNGGIACKDTPSTTTLVAVDANTKENIRQDNQEEDGSESSDEGTEQDREHLTHFKTWGKPTGRDQPSARVRKVTLSGLPLNADLTLVQSLIHGGAVEYMALAPASPESRALTAHVIFVSADACDKFYDKYPNGIELRHQSKHYAVMVEKGKNVDVISGMMQGYLECGATRVLKVSPVDDDWGIVALHRLAEGKQKIRHVEAIVDVYRNDNRTVMFRFGNITHAVQFKGVLIRSHDFDGCSVTFAEDPCEAAASFHYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL14</accession>
    <name>A0A0D2BL14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239864.1">
        <property type="nucleotide sequence ID" value="XM_016374588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL14"/>
    <dbReference type="STRING" id="91928.A0A0D2BL14"/>
    <dbReference type="GeneID" id="27327305"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00222"/>
    <dbReference type="HOGENOM" id="CLU_009969_0_0_1"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12717">
        <property type="entry name" value="RRM_ETP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034931">
        <property type="entry name" value="ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="329"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="365"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="695"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="763"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="518"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="90565" checksum="A622ACEAB4F4285D" modified="2015-04-29" version="1">MPDYFFHIAIELFTDSISPTKEDRQTRPPYLGRFSKALKPFSHHSRHRSKDRSLHVNNNSSTPHAPTQASLGSGTEPPDIPHSHPTDHRLDKIFLQGQDMSRSGGKDLVLTEDNGIGKGIGSAISGHHLKGRYQPLEDPNDAEGWGIVHLYRDSEETSGLFADSAYRSSDLWSDGQRRNPPSGKPHPPPKDEECTSLCILAVPSYMTPSDFLSWVGEDTRSEVSHFRMVRTARANRYMVLMKFQHGKKAREWQHEWNGKVFNSMEPETCHVVFLKSVELLQTSSMERSNDLGSPTTSYPRMSNDPFIPASTTSKPLAPRTPSLVELPTCPVCLERMDETTGLLTIPCQHVFHCTCLEKWSGGGCPVCRYTHDDFSSRVGSSKFKSLKGNEYEPNDGPLECEVCHVDTSLWQCLICGKVGCGRYEGKHAYAHFEDSGHTFSMDLESKRVWDYAGDAYVHRIIQDAAKPGEKLVELPGRRREPTALEGQEDVEVAKMDNIALEYTHLLTSQLESQRVYFEEVVERAVDKASQANKNAERALEECRRATDKLRTLENEHDVVAKGVVPELEREKNRLEKRCVKFEEMARSFNQKYQEEKTLTANLMERVKYLEETQIDHLKQTVQRLEEDNATKDLLMEGLREEHRDAMMQISAQQKLQEMVAKGELEQEDLDGAIIEAGPAKKVPPRRGRRIVNGQSRNVSSSAAAHSPHPASGPPPSVEPSNGIHTAYNDIFGEISASKDWDEAKAKQIMEECKSRLVGEGLLVLPSATDGDGDDSDVEGEAGHEDSAEGKPRSGNANKKRKGKKKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLV9</accession>
    <name>A0A0D2BLV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239761.1">
        <property type="nucleotide sequence ID" value="XM_016374485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLV9"/>
    <dbReference type="STRING" id="91928.A0A0D2BLV9"/>
    <dbReference type="GeneID" id="27327200"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00117"/>
    <dbReference type="HOGENOM" id="CLU_007091_2_1_1"/>
    <dbReference type="OrthoDB" id="4236860at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF130">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTO (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="696" mass="77982" checksum="A4BD347A534D3F15" modified="2015-04-29" version="1">MQKPQGQSRRIVRPELKRRRPPLACVQCYSRKIKCDRESPACGGCVRIGKGHECIYRNAPSDDHRPVQTWPRPRPRPSAKMLTDEGALTTRHAAYLAPSAVEGGMAHLKGSEMSTKFYGFSYPLNLYQQFPELRSYIAQIKCQNPTINELRDEIYGIANSLRPRYQQHSSQEGIVERFEALIPTRNTADMLVQTYIDRFEVIHRIIHIPTFMADYCGYWDKTCLVSADFFAQLLLMMATGSSLHPEVAFNGVQLNPSRRFCLRWIDAVESWLVPSTFDPASESSYTLTTHTLLVVAKRANSVHESALWSSTGSLVRRAMAAGYHREVGSAMHISLFNREMRRRLWSTVAELDLQASIERGMPPSLRTSDFNVHAPLHLEDEALRDSIDGMPPAPQLLDTWSTCSCQVLLSRTFVARLEICSLINGSQDRDVSDEVLQLSDTLIRALQEIPAWRDTGRSPRDQQTVTYVRSAVAVILDQYLIVLHVPMAIQSPPTWKTHVSRLARLDAATGILMHHRRLVDDGILSECAYQHGLVLGALNLCHELYLSWTNSSGMSHMSTLTSPEIAQAHLVVVERALQLLHGRVSTTLEGLNEFYVLAMVIGLIKSKICPQLTTTAEHVAAQQVIQLSEEVRSAIPTLSADDAEDASAFMCTQPDQSNHGFAPASPSAQVDYNFSMFPDDLGFLHGDFLLDEIQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLX5</accession>
    <name>A0A0D2BLX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232410.1">
        <property type="nucleotide sequence ID" value="XM_016383787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLX5"/>
    <dbReference type="GeneID" id="27336553"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09470"/>
    <dbReference type="HOGENOM" id="CLU_000960_8_3_1"/>
    <dbReference type="OrthoDB" id="4369475at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13750" checksum="52BE8C90E4F5488B" modified="2015-04-29" version="1">MGMGFGMQQASLTVQTVLSRCDVATAETLMTFSQTLNGSIFVSVGINLFDNRSSHGLAGISLIDIGVVVKFGATELRDMIPHRLLPQVLVAYNTALRITFYAATSLACVGIIGAVVVEWVSVKKDEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM78</accession>
    <name>A0A0D2BM78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232515.1">
        <property type="nucleotide sequence ID" value="XM_016383892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM78"/>
    <dbReference type="GeneID" id="27336659"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09576"/>
    <dbReference type="HOGENOM" id="CLU_452722_0_0_1"/>
    <dbReference type="OrthoDB" id="5428890at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="603" mass="68519" checksum="4A9646FFAFC90898" modified="2015-04-29" version="1">MPIPLLPMMDANHGAEFHLDARLRERLLNALQYGDAAAERSNTDNNQLDPYLEYICTRLMRSSADGKPHLGNLVELFITAVEYFGHQERINHTVGKYLRTQEDHLRSIFSLDDSDEFAKARWRRERINDVVSSIALWIMEEDFHERFENQSIRAVFFSRVKAGFIGYSNLALNDNQLDHDGNFTIWSIADVLGLLPTLESWVEAPSADPHEEVFQSRLNARLINRIGQVRFRWTFNCSEHMQLRNNELYLFCMPSRHLLEPKLVENDTPDAALDSLGFRRERGEEILKSYYLLFGPQNKQLLKDLLASPHLSSPHDSVLKEYCEENAAGRAAESLARWSKQEFKYLWPSIKYLEHFLRDIEPDKLIKLIYRDRRNSYAWWTFLLAFIVVILTLISTVFTVIQGLKAFFPSGGATSVVIVTMNAQPAATGTTTPTSTVFSTRSSTAAASSTTTAAPTLLSTAVFELESSCFDVYTTFCVPFYSEASNCANIYTGNSTNLSRYSAMSSCYCTDSSMLSLASRCEYDFGKSCVGDIQSLGNVEWNWTDPFPGICCCNDHFNANSICTIFDKLLVLFLLPEFRNNSGYCRSSSGWCIRARGGHLDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMA9</accession>
    <name>A0A0D2BMA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">succinate-semialdehyde dehydrogenase [NAD(P)(+)]</fullName>
            <ecNumber evidence="6">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00309</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="6"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239951.1">
        <property type="nucleotide sequence ID" value="XM_016374675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMA9"/>
    <dbReference type="STRING" id="91928.A0A0D2BMA9"/>
    <dbReference type="GeneID" id="27327392"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00309"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF11">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="493" mass="52585" checksum="3F08FF757F93ACD6" modified="2015-04-29" version="1">MSVSASLLKDPSLFVVDKTYIAGQWVSAKSGETFEVKSPATDAVIGAVPESGFDDLNDAIGAAADAFEGWKRLSGRQRGRILRRVFELLVENQEDLSTIITLENGKAKADATGEVVLSANFFEWYAEEAARIYGDVIPNSTPNSRTRVVKEPIGVCGLITPWNFPLAMGVRKIAAALAAGCTIVLKSDGLTPFSSSALAVLGERAGIPKGVLNIVTAARNTPQLGLALCESNTVKKISFTGSTRVGKLLYQQSARTLKKLSLELGGNAAFIVFDDADLEVAISSLLVAKFKVTGQTCVCANRIFVQQGIYDKFSQKLVEEVKKFRVGDALAVADGSITHGPLTNGTEKVESHIKDAVDKNAKVLLGGNGLPHLGRNFHELTVLGDVDDTMQVTKEETFGPVAALLKFSSEDEVIKRANNSDVGLASYVMTTDLARSYRVSERLETGMVAINTGVVSDAPVPFGGVKHSGFGREGSKYGLDDYLTLKMVVTGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMD1</accession>
    <name>A0A0D2BMD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_09616</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232555.1">
        <property type="nucleotide sequence ID" value="XM_016383932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMD1"/>
    <dbReference type="GeneID" id="27336699"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09616"/>
    <dbReference type="HOGENOM" id="CLU_006329_5_1_1"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="696" mass="77125" checksum="79EFD65490E1215C" modified="2015-04-29" version="1">MASEASMDKPRQRVRAFKACQRCNQRKVKCDAAQTGLPCTRCKVDGVHGCAFISSRRGTYDRWRSAKARSRTPQASSTAATPVDSTSPEASTIGGSSTTHLPTTVPPASARSNTLALGFENFLRQGGRDADGLVGKYGLVLLGDSSPLTFALKELQPDKRDKSSLQSSDAVETSQLVTSSRSGHPSHLTAADLTYLQSKGALTPPTNEYLDALIQVFMDKFYPLCSIVDRSEFMRQHRSRSLPWILLQSACLIGATYSDASILKKAGFKSRQAARRFFYDKAKVLYDVGYETNSVVLLQSIVMLTYWGPDLKGYWNPCSWVGVAVTIAESLGIHRTAGYSNVHQDKGLLRRLWWMIAVRDAYCGTLLGRPFRVNMSHSDGPMLTFDDFGPEDGTTTNSSDSDDTSRLYVHYQIQVAKLSLILRRIVNTRFNVGLDSTTPQVLRDLLGQWRNELPAVITWSDHGGSSSIFSECLKILYHHHLILIYLPRGDAGAASSAGLANMESPTSEIAESAAQTIASTSLSLMTRSMVHSLPQEVFPAFFVAGIVFFRLIRRSSSLIAQLGQAALDNCQIVLNEVRDCWEPAFWGMRIFEFLLAGLKKNRSSLVDKQDLTMSSSEAVRSDLQQMLDHTPDTQDHFALQNAVEMGPAIHNLRNAAQQDTLLTTQLYDRFLDPDNYFIMPTSLADQDTIDFDMAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMF3</accession>
    <name>A0A0D2BMF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NCS1 nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240329.1">
        <property type="nucleotide sequence ID" value="XM_016375053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMF3"/>
    <dbReference type="GeneID" id="27327771"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00688"/>
    <dbReference type="HOGENOM" id="CLU_021555_2_0_1"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="57688" checksum="C4D510619DE2B972" modified="2015-04-29" version="1">MEDERLDVSLLSVGVADAKPDMMPTNSFYWMSDALAGGSWSTGASLITLGFTARTAIPIAFCSYFLVSIPSALTGRIGTFTHTPFPVNIRASFGPWGSVVPILARMIIGLIWMFVQTYLGGTYVTILLSGIWPSYNRIPNRLPASAGIESKELLSVFIFWCIQVRLTTCMSGKLRYLFLVKAIIVPICYFGIFIWAMIATNGGDTPYIRGRSTGSGWAVLQAINALAGGASAVETNAADFSRYMKHGSGNFWQILWIPITNTLPIVVATLATGAAQAKYGVYEWNAADLFLLWNNRAAQVFCAAAFILSNIGINISANAVAFSNDMTSLCPRYFNNFRSSALCAILSFAACPWLIVQNAPALLNFLGSYACFLSGIAAIMIADFYLVRKGRVDMREYYNFPGGIYWYWFGFNWRAIAAWVISFAPNLPGLIHGVNAKVPNVQPYTYYFSWLFGTAVSVALYMLINYFFPPKASLINYTLYEDDMIVSETNDVEAAAATELRRESVTEKQGAEETVVVPVPVIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMM1</accession>
    <name>A0A0D2BMM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232620.1">
        <property type="nucleotide sequence ID" value="XM_016383997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMM1"/>
    <dbReference type="GeneID" id="27336764"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09681"/>
    <dbReference type="HOGENOM" id="CLU_650583_0_0_1"/>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="422" mass="44883" checksum="7F093D5508465967" modified="2015-04-29" version="1">MQSIGGNTGSQSSSPSTASAQPGSPFNPDSITRSSAPSVTTTSSTSSGTVASVQDATGQIASQSTTPSSPNVSSSNGSSSNIGGIVGGTIGGLLFGLVVGMLFMFCWARRRAAKASLSSRRAGKISPEKNGTDRSTLQAYESPSDPARWLVYLPQPSDDTELKHQVKTMYNQIDLHVENFYTDRDGGLLTEAVQSILARYETDLLPAPVATIMASTSSKKAVIKHCLTCTIVSRIDAVRPIPQSFLPSEIAALPALLAKNADVEHVSRKKGMHSLNLANHIVSLSSESWLTENDPVFDEAYSTWRVLTAYIRPSAASLTPTQEASVTSEAANFTEAFGPWSKSRGNAAQKANLEEIMRNAIGVGTLLFSQPSVCEFRWIQTSKRHANSATFYITPALLRTSDASGHALSSPHTLLKAAKNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMU1</accession>
    <name>A0A0D2BMU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fumarate reductase</fullName>
            <ecNumber evidence="6">1.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Irreversibly catalyzes the reduction of fumarate to succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="6"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240479.1">
        <property type="nucleotide sequence ID" value="XM_016375203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMU1"/>
    <dbReference type="STRING" id="91928.A0A0D2BMU1"/>
    <dbReference type="GeneID" id="27327921"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00838"/>
    <dbReference type="HOGENOM" id="CLU_011398_4_5_1"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF12">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="8">
        <location>
            <begin position="8"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="469" mass="49982" checksum="78E9DAD12A6FF48D" modified="2015-04-29" version="1">MATSPRRVIVVGSGLAGLSAASELVSKNVPVVILERQQKPGGNSIKASSGINGVPTRFQSDSSDSTESFYADTVKSVSPNFMRTATESRQRLISVLTESSASAINWLVDVKGVDLSRVAALGGHSHPRTHRGAGQTPPGASIVTTLLKQLQANDLVKMETNSTVTKVLSGPGGVVGVEVSRDGKSEKLEGPVIFASGGFAGDSRGLLAKHRPDLHGYPSTNEALPGSSDLLAALGAQFLDMDQVQVHPTGFVDPKDPFKVTKFLAAEVLRGEGGILLRSGKRFINELETRKVVTDKIIREAPKNTDPTKQWDILLVLDENTYQATKSHVDFYLWKGLMQKTTISELSDSQTAVESIREYSDIVQGKNPDHFGRRNFGNWTVQNPLPETTIYVGQVTPVVHYTMGGALLTPEAQVVDASGSPIRGLWAAGEVTGGIHGANRLGGSSLLECVVFGRIAGQKAAEFVQSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNC5</accession>
    <name>A0A0D2BNC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232845.1">
        <property type="nucleotide sequence ID" value="XM_016384222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNC5"/>
    <dbReference type="STRING" id="91928.A0A0D2BNC5"/>
    <dbReference type="GeneID" id="27336990"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09907"/>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="95"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="353" mass="39010" checksum="DDA404339B171631" modified="2015-04-29" version="1">MASYLDEKYLLSLADIDPELKAFLEKANLPPVNYDDLADFKVMVEKRNAGAMEALGQPPAEIKQTELHYPTRDGSKVRAKLYQPTTPPKEGSPLIVMYHGGGFCIGAPEGEEQTCRNFVQAFGAVCISAAYRLGPEWKFPYAVKDSWDCLKWAAENAKSWGADPTVGFVIGGTSAGGNITAVLAHVARDEGLSPPLTGQYLAIPALVPHDKVPEKYKKYFLSFEQNRDAPVLPVAAIDMFMRGYQPDDDDAVWYAVFNHPKGHANLPPAFFQIDGMDPLRDDGIVFERVLREEYGIKTKMNVYPGLPHGHWGFFPFLKASETFRKEQVEGMGFLLGREPDFSKVVTTAVAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNP2</accession>
    <name>A0A0D2BNP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240371.1">
        <property type="nucleotide sequence ID" value="XM_016375095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNP2"/>
    <dbReference type="STRING" id="91928.A0A0D2BNP2"/>
    <dbReference type="GeneID" id="27327813"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00730"/>
    <dbReference type="HOGENOM" id="CLU_069194_0_0_1"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="301" mass="32825" checksum="1CE2AFBAE1153C04" modified="2015-04-29" version="1">MGKGHAEDAISTAQFARTKSDGNQNRPVLLRGGYTNLLLQHHSALTAGLIRLYSRLLEGKGWDGAPVDEVNGSPSVHCILERIGVIGADEEFDEDLDTSDHNERPQLAPIKEASAPAGVKKPAKSKPHHAAAKRRSQSRVSSIQTEPESGIDKSRNSSQHVRGIRLASPSNSEMYSTVFESGSSDTPSTWESPGFADELFSASATNGDAQIRYERDMDTTFPTEPSFPTQHHQLPDANLNAQSTAPLPFDSGFEMQVTDNFVDATCDMNFYDWDGNNSFGIGTEPGLFVQRNNTWNPSVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPN4</accession>
    <name>A0A0D2BPN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233260.1">
        <property type="nucleotide sequence ID" value="XM_016382557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPN4"/>
    <dbReference type="STRING" id="91928.A0A0D2BPN4"/>
    <dbReference type="GeneID" id="27335314"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08231"/>
    <dbReference type="HOGENOM" id="CLU_2512651_0_0_1"/>
    <dbReference type="OrthoDB" id="4152516at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="85" mass="9131" checksum="562899A645B02516" modified="2015-04-29" version="1">MAAPQVEQVETELGPHVGEITAAVIGASFGAMLLVIFALILCLHKRSKASSTVRFAAIQNLYGQPLFPTSQSILSHNILKKAQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPX3</accession>
    <name>A0A0D2BPX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein DGCR14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240761.1">
        <property type="nucleotide sequence ID" value="XM_016375485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPX3"/>
    <dbReference type="STRING" id="91928.A0A0D2BPX3"/>
    <dbReference type="GeneID" id="27328203"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01120"/>
    <dbReference type="HOGENOM" id="CLU_024820_0_0_1"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="53418" checksum="5987FCBD14EFB641" modified="2015-04-29" version="1">MASADSSTALMRRSSAQDVAAMPPPPFKRIKRPPKILDEDEYTTALSDIIARDYFPGLLESQAQHEYLAALESGNDSWVAEAAQKLREAALPTSSKGKRRTARNTRFDHPSATPLRGQPVADTPLGYTGSETPSVASVAASVDTAEPQPGVDTSSLSLSAFQAKYTSEDNESFNALLDKQNLKRRQKHAYLWTQDQRIPSTRLLEHRSREQQRLNTADDKSSSSSTSKELALHTGATDDRPAKLDSWTIKRPDNTFMFNASSVDEDGLQTVQEVREQNSKAGPKQVVYTNTRFPPVQYVDDPGPVPPSPSLNTDIVNSRRRLADTDSDAGAGGGGSEYNYAGGETPRVNGYAFVEEDEPENISSAADGPSYRDLLAGQVADPTPNPFKLSEIRKREDLHYRMVEKAARQKRDKDRQTRLRPGDRAGAPVDGGSNSKTSGNMTPAARRLMEKLGGRTPARGASGSTGSTTPVSKGMWTPLRTPRRSDLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPZ3</accession>
    <name>A0A0D2BPZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233415.1">
        <property type="nucleotide sequence ID" value="XM_016382712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPZ3"/>
    <dbReference type="GeneID" id="27335469"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08386"/>
    <dbReference type="HOGENOM" id="CLU_009942_5_0_1"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF20">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="53"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="538" mass="59180" checksum="70A9FFDA6D1844FB" modified="2015-04-29" version="1">MKTVFKNARIFTGSSDSADHFKHSCMVVQDDVIEHVGSWSDPQVAAAQKDGAEVFDMDQRTLAPGFVDGHMHLLMFGSSLQKISLDHCKTLQDIQATIRHAAKQDTTKPRILCHEWMHFMTDSKALASDLDGLDELNRPIFVDAKDLHSTWCNSAALAELGVEDMSDPPGGQIHRDEQGNATGLLSEAAAITIVWPHLAKVASMEEKKTAIRKAVKTYNAAGYTGMVEMAMDENAFAALLELRAQEPLSIRLAMHWLIYPSETNEESLVQVDRAIDLWRQYNLTTSPDFRIAGIKVIGDGVIDACTAALLQPYASNGVSCEPLWNADHLKAVVQRADAAGMQCALHAIGDATIKMAIDVLETVASSGRRHRIEHLELTSRGDAKRLQEAGITASIQAVHADPSILREWNNLLGEERRGRAFAYREFLDEQVHLALGTDAPTAPNLPLPNLYTATTRRSAREPSSDEVVNKHFALPLLNAFAAATHGAAYSCFMDEITGKLEPGKKADFIVLDMEWSPDDLLRAKVLQTWFGGKRVAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ89</accession>
    <name>A0A0D2BQ89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_01687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241324.1">
        <property type="nucleotide sequence ID" value="XM_016376048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ89"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ89"/>
    <dbReference type="GeneID" id="27328770"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01687"/>
    <dbReference type="HOGENOM" id="CLU_023254_0_2_1"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW21108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="55035" checksum="7A9E935ABE5510D3" modified="2015-04-29" version="1">MLFILSTNSQKPNEDKQKIIRRHVMLGKNKGKARPSKRQTPIVSCISESVGPHGNPVVALSLVADMYRSFIPARVGSDCSCSELVADVEPGTFGDIMKFAAVAPKILFPLAVLIGFEPQDRDWCEGLTYDAAYLHATIFSVEVLVDNIMVRRHQDVNKNATRHLLKSVQLLREKLLENEDVFASDSTMRVILVLAITAYYLWDHATAKKHMKALRQIVDLRGGLATFKAKKILLTLLKCDLCISLHTGVKPIFFNDPFLEPYMPYPEKEVLAIGQSPEFLRHLQMQDGFLRDVHHDLAASWLVLQRFCSLSNLAAQSNGVLPTQLHVQTMASVMYRLLDLNHFQARSVDEMIRLGILALTHHIFLQYQHLKLPYSHFQSRLERSLVNLQLFENANPELTLWTLMVAAISVPNMAEDAWLLESLRTLVQICKITSWRDLRGLMKAMIWIDVVHDKPAKDMYARVVSDYTPIKANSRLANDVGSALTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQC7</accession>
    <name>A0A0D2BQC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233555.1">
        <property type="nucleotide sequence ID" value="XM_016382852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQC7"/>
    <dbReference type="GeneID" id="27335610"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08527"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="51049" checksum="1003873C464D21EE" modified="2015-04-29" version="1">MAQSDTNDSIALETVKSRNDAVEGRGESLENTHNGHEEDTVPDLPPIDRGRAAWRMLFSAFIFEALLWGFPLSFGVFQNYYSRLPQYANQPYVSVVGTVASGISYMGAPLIIPLLKRLGRYRTSIIWVGWSMCIVGVLASSFARNLPTIIFTQGVMYGVGFTLFYYPILGMVNELWVARRGMAYGILCASSGLSGVVMPVTPEALLEKFGLSTTLRSVAIGIAILTGPLIPFLKGRTTISPQQQRQPTTAPTPTPTPHTDWSFLHVPLFWIYTLSNLMQGLGYFFPSLYLPSYAATTMGMGSRRGALLLSVMSVAQVLGQFSFGYLSDRRFSVNTLAVTSTLVSATAVLTLWGLARSFGLLCLFAVLYGFFGAGYTAVWARMGTNVTRDTTAAFAAFGLFNFGKGLGNVFAGPIGANLLIDDFSSSTTAHSADYGATKYKAVVLFTGSCMLASGASALTAYLKPWKAPAVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRT1</accession>
    <name>A0A0D2BRT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_01689</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241326.1">
        <property type="nucleotide sequence ID" value="XM_016376050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRT1"/>
    <dbReference type="STRING" id="91928.A0A0D2BRT1"/>
    <dbReference type="GeneID" id="27328772"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01689"/>
    <dbReference type="HOGENOM" id="CLU_031730_1_0_1"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239280" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="22"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="22"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW21110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="393" mass="40147" checksum="E52815E1DDC5F6A3" modified="2015-04-29" version="1">MSLIRSTTLVGALALVSKVSAHGIVSGIVAGGQWYSGYNPSFKYSNNPPVVAGWSIPDDGDYGFVSDYTSPDIICHKGATPGGAYVSVAAGESLELQWTVWPESHHGPMIDYLASCGDDCTTVDKSQLKFNKIDEAGLVNGSPAPGKWASDDMIANNNSWVVTIPSSIAPGKYVLRHETIALHSAFNAGGAQNYPQCINLEITGSGSTSLTGGTLGTELYTAQDPGILLNIYYPALESYDIPGPPLFDGASSSGGSSQNSAASASTSISAAVSTSASASASTSASALLTATPHSWGAWSNITSVPSKPIAVVSSTSAVAVEPTHTEAEEECPSETASVSFSSVPTVTSNVAAAVTPAPDSTSPVAPGTSAVSFTSTITGRIGQTTKFVCYLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSS6</accession>
    <name>A0A0D2BSS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_02050</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241686.1">
        <property type="nucleotide sequence ID" value="XM_016376410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSS6"/>
    <dbReference type="STRING" id="91928.A0A0D2BSS6"/>
    <dbReference type="GeneID" id="27329133"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02050"/>
    <dbReference type="HOGENOM" id="CLU_013253_0_0_1"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF23">
        <property type="entry name" value="ASPARTIC ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239306" description="Peptidase A1 domain-containing protein" evidence="12">
        <location>
            <begin position="20"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="99"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW21470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="414" mass="43634" checksum="FEDBBE7DC1394AEA" modified="2015-04-29" version="1">MLRLQILFLALLFITTVFSSPIRQKQKRSFKIPRIAQPNYKPNGKAAYKRALFKFGFGDISFQPNGEIATKIQAATNASVDATEDGETIATPSQNDAQFLSPVNVGGQTLVMNFDSGSSDFWVFNTNLDNADQQGHTIYDPTKSNASKALTGSTFNISYGDGSFASGPVGVDTVDIGGSTVDAQAIGLPNVVSDSFVTNTASNGLVGLAFSQLNTVKPQSQKTFFDNVMADLTEPVFTAQLLSNAAGQYEFGQIDTSLFKGQLQTAAIDSSNGFWEVASTSAAVSGQTINLAGGSAILDTGTSLMLVGDDLVVGYWNNVEGAQLNQQAGGVIFPCNAELPDLQVAIGNHLATVAGDNMNFANVGTDTQTGQDFCFGGLQSSQGLPFSIYGDVFFRSNFVVFDGAGPSTSFAPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BV36</accession>
    <name>A0A0D2BV36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Cytochrome P450</fullName>
                <ecNumber evidence="16">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="16">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_07881</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="16">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="16"/>
    <dbReference type="EC" id="1.6.2.4" evidence="16"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235310.1">
        <property type="nucleotide sequence ID" value="XM_016382208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BV36"/>
    <dbReference type="STRING" id="91928.A0A0D2BV36"/>
    <dbReference type="GeneID" id="27334964"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07881"/>
    <dbReference type="HOGENOM" id="CLU_001570_7_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06206">
        <property type="entry name" value="bifunctional_CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11068">
        <property type="entry name" value="CYP120A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bifunctional_P450_P450_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF127">
        <property type="entry name" value="BIFUNCTIONAL CYTOCHROME P450_NADPH--P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 16" id="KW-0288">FMN</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 16" id="KW-0521">NADP</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="18">
        <location>
            <begin position="496"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="668"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW15094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1055" mass="115808" checksum="BF4ECE09F3525CC6" modified="2015-04-29" version="1">MAYPVPQPPTIPFLGNVWDLDPKNSMQSLLHLGEKYGPIFKLSLVGRERYFINSAALLDELCDERRFCKAVTGALQEVRHGVKDGLFTAYPGEHNWDVAHRTLVPAFGPIGIHDMYDEMYDIATQLVAKWARVGPDEKINVTDDYTRLTLDSIALCAMGKRFNSFYSENMHPFVNAMVGFLLESGRRAGRTRLESLFSRAAARQFEEDIATMKSVAEEVIAHRRANPTDKKDLLNAMLYGKDPKTGERLTHESVMNNMITFLIAGHETTSGLLSFATYYLVKNPEVMRKAQAEVDAVVGKGPVSVQHMSKLPYIEAILRETLRLQPTAPAFAVRALDTVAGPTVLGGKYHIPHEAVLVALLPGIGRDAEVFGPDCNDFVPERMSQENFAKLPKNAWKPFGNGARGCIGRPFAWQEAILTLALVLQNFNLRADDPSYQLQIKQTLTIKPDNFSIRAVLRDGIDPLKLEKKMHVATETDQVVQRHPAAVKSAESGKPMLVLYGSNSGTCEGLAQSLAGSAGNRGYFATVKPLDAAVDQLPTKQPIVIITASYEGNPPDNAGAFVEWLQNVSSEKLKDVKFAVFGCGHHDWVTTFQKVPKLIDSELSSRGAEQIASRGESDVALGTIFDDFDSWQDESLWPALSADASAAEVAEGLSMEISTTTRASHLRHKVMDALVVENTRLTPVDTPEKRWATFKLPTSLTYEAGDYLAVLPINAAATISRVLRRFGLPWDAMMTLQKGAHTTIPTGVAMPVTAVLGAYVELSSVATRKNIATLVRYAGADEKPLAEELSATTGQLSVLEILEKHPSLNVSFPVFLSMLTPMRIRQYSIASSPLSNPTEASIMYSVVRTETGRIGVATNYLKDLQPGSTAQIMIKKSHASFHLPRDPKTPIIMVCAGTGLAPFMGFVQERAARFAATSDGGVDGDTSEPFGQAVLIIGCRHPDVDRLHAKQLADWQDQGVVRVFYAFSRDPDRSDGCKYAQDRLWRERELVSDLFDQGARAYICGSSALGKGVGQVAAKMAVEGAKKKGKEVSIDKGLEWWEGLRGERYAVDVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BV82</accession>
    <name>A0A0D2BV82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_05209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235380.1">
        <property type="nucleotide sequence ID" value="XM_016379553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BV82"/>
    <dbReference type="GeneID" id="27332292"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05209"/>
    <dbReference type="HOGENOM" id="CLU_131535_2_0_1"/>
    <dbReference type="OrthoDB" id="3500395at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW15164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16493" checksum="855B5FD221964F7B" modified="2015-04-29" version="1">MATNNVEHYLGDLEAATKIIPPNEPYIMMNLMRFKSHATYNADYQGPKVATGKEAYLTYKDKFNDRVREMGLESSIVLFGKAYTQIVAGPQEGESWDVVVLLKFSSWAAFKSVLEDEKYIKEIQPHRLAALQELRSFAVIELLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVV2</accession>
    <name>A0A0D2BVV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235625.1">
        <property type="nucleotide sequence ID" value="XM_016379798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVV2"/>
    <dbReference type="STRING" id="91928.A0A0D2BVV2"/>
    <dbReference type="GeneID" id="27332538"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05455"/>
    <dbReference type="HOGENOM" id="CLU_048908_1_0_1"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="66"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="390" mass="42897" checksum="995D0C6EC5466320" modified="2015-04-29" version="1">MPPKRRSDAISRDDPPSSPDAESDSDSETVTQSRRQRPRSSSESSAASSASDSHHHDPHGTLVKKLVRLALATEYSRTPLRRSDIHTKIFKDSNTHGRSFKTIFNSAQDILKDTFGMHLVELPSKEKTSLKDRRNQATQTKSNTSTSSKSWILVSVLPDKLKTNPAVVQPTKAPSQETEATYTALYTFILSLIYLNNGALTDQKLNRYLKRVNMDTYTPFGALEKLLARMAREGYVEKRRDTTSGEEVIEWVSGPRGKVEVGAKGVAGLVRSVYGYGAVPLGMVAGATATQPGRSRRGSGSGSDDEGDSGPQRLVKIEEDELNSKIKRSLGIRFGRERQRGDDEDDSAGAGAGDSGTEQAIMPPPTRTSRTQTQQQTRSRRTRRQDADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWQ6</accession>
    <name>A0A0D2BWQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235945.1">
        <property type="nucleotide sequence ID" value="XM_016380118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWQ6"/>
    <dbReference type="STRING" id="91928.A0A0D2BWQ6"/>
    <dbReference type="GeneID" id="27332862"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05779"/>
    <dbReference type="HOGENOM" id="CLU_078833_0_0_1"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="275" mass="30625" checksum="71E7A33AF6FE1D14" modified="2015-04-29" version="1">MSPTTAQAPPTSTTPRPPNSVKYTIEPVTSEADLPALAYLSGLALGPDPYSEFRERYGPQSLYDDTLEKLTNAMRDKSGQSSLFKVVLVPDSDEESGKETVIGLSQWRLGYLNVPKTDPFAIKRDNDAPSSTAQSVETTVVAKPNDDGEAEGLDIARAKKTPKPKPFYSNPLEEHGRMIWNSVITHIRGKRFMGLHRLVVHPSYQRQGIGQQLINWGTEVADRENVVSWLNARPAGSRLYERNGWQVVDVVEFDSPELDVPHTVTMIRFPKPRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZM6</accession>
    <name>A0A0D2BZM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237020.1">
        <property type="nucleotide sequence ID" value="XM_016378343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZM6"/>
    <dbReference type="STRING" id="91928.A0A0D2BZM6"/>
    <dbReference type="GeneID" id="27331077"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03994"/>
    <dbReference type="HOGENOM" id="CLU_021768_3_2_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="308" mass="35069" checksum="181CF9E84F7FCE7A" modified="2015-04-29" version="1">MFECFSSNDIEPVDEYDQIPFGLKWRMHWGKKETDPATGEAVLRLSNTKILKTHCINTEYQALKLIDRHTSVPCYKVLAVYNRPEGKVVEYEAYPGKPLEQAWPGMSAHQKNKVIADLGRFVEQLRKMQPPKQCVVGDATLGAALDHRFGSGRIGPFFSIAAFQEFERRGHKPQDFPESEVQKVHVPPKPYSLKFTHANLCPKNILVDEAGRIVALIGWESSGWYPEYWEYTQMCHATPKTMGDWLDAMCQVVPRYDQELICEEALRARYSGSVYDLPRSIRAPSPSPSELNAEQREIDDKNTESTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C1W1</accession>
    <name>A0A0D2C1W1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237855.1">
        <property type="nucleotide sequence ID" value="XM_016379178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C1W1"/>
    <dbReference type="GeneID" id="27331917"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04834"/>
    <dbReference type="HOGENOM" id="CLU_022328_0_0_1"/>
    <dbReference type="OrthoDB" id="4120272at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="818" mass="90222" checksum="713776129C7698E7" modified="2015-04-29" version="1">MCITEIWTYRDCGCRYNHSILCRSYRRGGTPCFAPNIQYPRDKWLEGAGIDNALTFRQFKGRTKPTEPQACPQHRTVYRSFLNPVCEDCLLAGVNWLSGDGIGPVPLTYPESEAAGGEGLVWDSEVKVEIESQSLQDQPVPSTTASDMSSHNSKDIDRTILDSHVEVTIESEGSRVSACEPPPSHLSSSHGEDSWFPSTGATSPESLGSCEQRYSDSSSEEKCEDSSGDDLSSDLGDSDDEGADSCDDQHCQHLPARGRSLVRGNGSVMKRSVTDPAPLLMPVEKSKSTRGLSTLRSIRSISLNFRSGSKTKVHAAPSEHLASGNEQCKLARSRSKNPFRAFRRRKGSQNYANTTRITHMLTTLEVHSSLEVDQLSFEKPRLRPLPPRKSSTGNLRSFTEPVQAGLGRRWFPGMAHQIQSPGPTGYCSQNHKHQEKGSHGFMCDLPVHKDVPFASQSDFSDFEPEETAQSSAEKSPPSHVVVRPTLQSSNDLPLRARIHGLETFELGLGASTSFPSNHEAQLSALDQEVNTVENAVPMVASTAFAMSKPQENFEIHDFASKHRYVADEDQDQETVLLDPNDATREDEIEAHSEETGTPSMLDPSEGFELISLSERKANEGFESDEVETDEQYPTATEPTHATLQPTQSNHRGEAEIQKVEELESEVLLVDMIDGSERVDSHIAETDQHSVEHNEPDQEQMFPESIPTIRILETDQIISLYSYARKPKRQAPEKIEEVVSDDVSEATAVSEDGDDSKISDLTTPPSSPLSIEKGTSPVWPSHPPRKSSLKRLTGFNYSLTPVVDPDFPTPSLPSTMNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3G6</accession>
    <name>A0A0D2C3G6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238385.1">
        <property type="nucleotide sequence ID" value="XM_016376815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3G6"/>
    <dbReference type="STRING" id="91928.A0A0D2C3G6"/>
    <dbReference type="GeneID" id="27329540"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02457"/>
    <dbReference type="HOGENOM" id="CLU_043304_1_0_1"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="369" mass="42036" checksum="0794982915511B69" modified="2015-04-29" version="1">MSDSVDRVFVHALATVRRLPRTGSSRPPPSARLQLYGLYKQSMEGDVESILPRPTLPTVSPDPNNSRSNNVHRYASRDLRIREAEAEIEKWDAWHSCAGMSRTEAKRRYISTLIETMKEYASGTQEARELVAELEFVWNQIKSQTGSSEDEDADSPTRRLERAGLKQTQSFASIPPSQSSRSGRPSQAIGRLQSDPNHLRVLSPVSQRDSDGVVEGEEIDPETGALLGPTTPEEEPPVPALEWRKSIEQHLRHLSTEVAALREQLSANHLLSSQSLSPSLTSRRRRIFYRVSTWAKWLTWVLARQLILDAGLVLAFILWARWKGYKERRVEDWARRRWNELRRGFVILDDWLKRTIPISTSRALGITKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6L6</accession>
    <name>A0A0D2C6L6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016377870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6L6"/>
    <dbReference type="STRING" id="91928.A0A0D2C6L6"/>
    <dbReference type="GeneID" id="27330601"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03518"/>
    <dbReference type="HOGENOM" id="CLU_018144_0_0_1"/>
    <dbReference type="OrthoDB" id="4120558at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="576" mass="64618" checksum="1FBD796468CBF59A" modified="2015-04-29" version="1">MHIQSIPREHISTLTKILQFPPDVEAREHIKSLASLVKLLPYTLRTSRAERIILRTQGSLCSLHNFLDLETVQTILGKIKVEIGSRLNSIVSQRQLLSPEQGNCITQLRHLHALWIPQYEFEKTFLCRTAETNWTYETSRCEACIISRIAGDLESLLNLRCTVRSRATSKHVAKHGFPRLQVWIDNWIEHLHHRFSGTGQIMDLDKVIAKNDEDGAALMTARSKVHEFRTQQHGIVHVDLLKHGQHARPGKQPLNETVDDESDASADPSSKGQSPYGNRTSLKRGKSEMVYSVDLETLASGPSRMQKCEFGVKEEEEEEEEEEEQRPYIPPRQNWNKNRVSRTSTVPRPAAQPNPRGRPARRDSWETESLESTYFSGATSSLYPRPQKRAAPAAPAATTTRAPRPRGGPAETYEKLIGPFPADSVAETIGLYSNADDNSRRSGEPDPGALETLPQTTYDPRRSLDAHAYAHWHSASQSRAPSPSPSTASYTTTDSDFTFEELGQGSAATTAIFILDESSGESGGMSSSPTSPPPRPRPQQQQAQLSPCSSSRWEDFYESQTRLRDDLDWFYHQEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C7P4</accession>
    <name>A0A0D2C7P4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239785.1">
        <property type="nucleotide sequence ID" value="XM_016374509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C7P4"/>
    <dbReference type="STRING" id="91928.A0A0D2C7P4"/>
    <dbReference type="GeneID" id="27327225"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00142"/>
    <dbReference type="HOGENOM" id="CLU_169171_1_0_1"/>
    <dbReference type="OrthoDB" id="5586401at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="2">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="79" mass="9555" checksum="7EA58B26A12498E6" modified="2015-04-29" version="1">MTGKQKVENIQADEDDELDEWDQRIFSTGCAEEQLRMNDCYYDKKDWRLCRNEMEAFRQCWKRKGNEERTLSKDAAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C7Q1</accession>
    <name>A0A0D2C7Q1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239795.1">
        <property type="nucleotide sequence ID" value="XM_016374519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C7Q1"/>
    <dbReference type="STRING" id="91928.A0A0D2C7Q1"/>
    <dbReference type="GeneID" id="27327235"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00152"/>
    <dbReference type="HOGENOM" id="CLU_015493_4_0_1"/>
    <dbReference type="OrthoDB" id="5069333at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="566" mass="64024" checksum="493B59732248349F" modified="2015-04-29" version="1">MGRRRRPDQLPPKPRTRAGCLTCRARKVKCDETRPQCRRCQIACRSCNFGVEIKWEADFVSRGLAFGREGIWSKSSTSPRTPSGPAEWATIPEIEPHYFLNYSSKIFEEPLRLESPMSPLRLQFSGYENTELQRLASRLNESLEDNVNITPYRFQGNTLITSRSFPLIPHIVDGDHSMLLDYYIQKLCPLTTPSKLSQSPFASLILPFTLMNSSSGILSILALSACHRAKNEPAWKVPAMKLKSQVLRVLQDRFSIEGVDKVASSSDTLVTMVILCLYEIIQDCDSGWVIHLKGAHDMVRFRKELQKVPGTDVEVNDLTAFAERFFAFHDVIGRTACGQVPLFGRDYWNFGETIVDVWMGCSPELVALLCTITELSRAAYADPSISITDSFVNACAVTRFKLESLEQVVENDEDDFLVMSAEIKRLAALLFLNCALYNTLPTTPLVVKLVEQIMRLISDSVDQGFVTGLTWPIFVAAVELNPYDDELWLDEATGTSIHGRRLVLKVLRAMEASTVSNIDRMRTIISQVWQARDLEEDPFPEAPNNHWSRNDWERYVAPISENINLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CBT1</accession>
    <name>A0A0D2CBT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241180.1">
        <property type="nucleotide sequence ID" value="XM_016375904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CBT1"/>
    <dbReference type="STRING" id="91928.A0A0D2CBT1"/>
    <dbReference type="GeneID" id="27328626"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01543"/>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="352" mass="39212" checksum="90D14025B0768B5D" modified="2015-04-29" version="1">MAGTQAVVLSMTFSSVAFIFVSLRCFSRILFAKRLFIEDVLIVLALVCSFGVAGAIEVERQYGLGENLYTLPPDQTVPGLKAFWASIFLYGLCLTLVKCSICCQLLRLFTETKYKVALQCILAFLIVFGIIAAVVTVFTCTPPRDFWEEMILPDKCINYVPWWFFSASVSILTDCVLCILPMPILKKLHLPPRQKYGLIAVFAVGGFACIVSILRLHAIYKFSRSSDASEANVEAAYWSAIEVNTGIICACMPMIRPLMNLIWKKIFRSSTRTVSVTSESREYNMKYGPPSALQSWRTPLEDVSFCTVPDNMKDYLEASGNHHRNEESESLAGATPSLALTRSDVECGRPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CDN0</accession>
    <name>A0A0D2CDN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase, type II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241865.1">
        <property type="nucleotide sequence ID" value="XM_016376589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CDN0"/>
    <dbReference type="STRING" id="91928.A0A0D2CDN0"/>
    <dbReference type="GeneID" id="27329312"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02229"/>
    <dbReference type="HOGENOM" id="CLU_045011_2_0_1"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="234" mass="26065" checksum="94DFF56B6F83AE6D" modified="2015-04-29" version="1">MSSRSKNVVFDVVGTLVSYDAVVDAVDKQLGARLQSKGIQPRMFVCLWMETTEREYTYLSISGKYVAFSEVFKEIFWRILWMGGIQEPRAFASSEDLAAILAAHQKLQMRPGAVECLKKLRNAGFTIWALTAGDLRRVGGYFSQAGVEIHPDNLISCDSTGIGKPDPVAYRPLLDKLVEENDGKKPWFAAAHMWDVSAARRTGGYIAKNGGSNYCKHELRFCHGLIAVIREKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y472</accession>
    <name>A0A0D1Y472_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_11856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229972.1">
        <property type="nucleotide sequence ID" value="XM_016386164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y472"/>
    <dbReference type="STRING" id="91928.A0A0D1Y472"/>
    <dbReference type="GeneID" id="27338939"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11856"/>
    <dbReference type="HOGENOM" id="CLU_083057_0_0_1"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="75"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW09756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="202" mass="23222" checksum="8A6FD46D93471973" modified="2015-04-29" version="1">MQPIVDINHLLNDADFEIQDEYDSVLDGAFDMRRKFSSLLMQARQLKTILLAKQAELDRCIAQRGRQRPGVPSIAESTRKKLRQQTRKLRQCMNENRLLRIQNQKMSNDLEAAHKELEKIDHLRCTICMVAFKNTTIPCGHSACRECLEFWLGQGKGCPWCKRGFQEGDIRDIYLGSSNETGNTREDDDDQTDIISLSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y6Z1</accession>
    <name>A0A0D1Y6Z1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_11615</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230867.1">
        <property type="nucleotide sequence ID" value="XM_016385923.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1Y6Z1"/>
    <dbReference type="GeneID" id="27338698"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11615"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003632">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="676"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="785"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1207"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1238"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1282"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1327"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1362"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1480"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="169"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="866"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1504"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1509"/>
            <end position="1523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW10651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1532" mass="171603" checksum="538FFC96F8A1AAA2" modified="2015-04-29" version="1">MSLVGNFTANADHTAEMRGAGAPGLHRRSSEVEETYHPFSRRSHDLDRRTTNESSKHDIEAIQEAKLESSSGSEDEEGHEQIRELARQFTRDSIGSTAGANPFHAEPGSSLDPASENFRPRAWTKAMFQLESSDDRFLARTAGVAFRNLSAHGFGAATDYQKSVGNIWLESVGIARRLMGVGQRRIDILRNFDGLIKPGEMLVVLGPPGSGCSTFLKTIAGETHGFNVDEGSYVNYQGISYQEMHKHFRGEAIYTAEQDVHFPQLSVGDTLYFAARARAPRHVPGGVSRNMYAEHMRDVIMAMFGIRHTFNTKVGNDFVRGVSGGERKRVSIAEAFLNMSPLQCWDNSTRGLDSANAIEFCKSLRISTDILNSAAAVAIYQAPQSAYDIFDKAIVLYEGRQIYFGHKDEAKDYFVRLGFVCPDRQTTADFLTSMTSPSERIVREGFENRVPRTPDEFAQAWKDSPDRARLLEEIEAFNREHPIGGPDLERFKESRKLQQAKRQRVSSPYTLSYGQQVRLCLWRGFKRLAADPSLTLTQVFGNTSLAFIIGSIFYNLDHTTNSFYSRGALIFFAILMNAFGSALEILTLYAQRPIVEKHARYALYHPSAEAFASMLTDMPYKIFNTLTFNITLYFLTNLRREAGAFFFFLLISFFLTLVMSMLFRTIASVSRTLSQALAPAAILILAIVIYTGFAIPVNYMLGWARWINYLDPVAYGFEALMINEFHGQRYDCATYVPSGSGYGEGIAHRVCSAVGSVPGQTFVDGDVYINSAYKYYASHKWRNFGILWAFLFGLMFTYLVAAEFVSAKKSKGEVLVFRRGQQPAALKKLPASDAEGGSSGAFVTADKDHSELQPISSVIQKQTAIFQWKNVCYDIKVKGGERRLLDHVDGWVKPGTLTALMGVSGAGKTTLLDVLATRVTMGVISGEMLVDGLQRDDSFQRKTGYVQQQDLHLETSTVREALNFSALLRQPAHVPRAEKLRYVNEVIKLLEMTEYADAVVGVPGEGLNVEQRKRLTIGVELAAKPQLLLFLDEPTSGLDSQTSWSILDLLEKLKNNGQAILCTIHQPSAMLFQRFDRLLFLAKGGRTVYFGQVGESSKILTSYFERNGAHACPPDANPAEWMLEVIGAAPGSHTDIDWVETWRNSPEKRAVHEELDTMKDERCKLARATSDPTNKASYREFAAPFYQQLYEVLKRVFEQYWRTPSYIYSKLSLCIASGMFIGFSFFKARNTIQGLTNQMFGIFMLMTIFGQLVQQIMPLFVTQRALYEVRERPSKAYSWQAFMMSNIIVELPWSALCALLIFVTWYYPIGLYENAEPTNAVHERGALMFLFILAFLLFTCTCAHMVIAGIETAETGGNIANLMFSLTLLFCGVLVGPKALPGFWIFMYRVSPFTYLIDGMLSTAVAHTLVTCANNEYVHFSPPSGQTCGEYMQPYIARSGGYLQDPGATANCSFCSTRDTDAFLSTVSAHPNLMWRNFGIMWAYIVFNIFGAVALYWLVRVPKKKKNGRKGEEVSEPTMKESAPEPTQQNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y770</accession>
    <name>A0A0D1Y770_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230972.1">
        <property type="nucleotide sequence ID" value="XM_016384370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y770"/>
    <dbReference type="GeneID" id="27337138"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10055"/>
    <dbReference type="HOGENOM" id="CLU_139257_2_0_1"/>
    <dbReference type="OrthoDB" id="4357148at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12181" checksum="806B79BA5AA7363D" modified="2015-04-29" version="1">MATNADREFDKQDTSTDDIPQGGDTVDNSYASRPGQSHIPVVKDETPVEQPNDARNPDSTQALEQDESEAIDKRNILKGDRTRHATKPKGTYRDPEGEDDLPADDGTSAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YEU7</accession>
    <name>A0A0D1YEU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233792.1">
        <property type="nucleotide sequence ID" value="XM_016383089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YEU7"/>
    <dbReference type="STRING" id="91928.A0A0D1YEU7"/>
    <dbReference type="GeneID" id="27335848"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08765"/>
    <dbReference type="HOGENOM" id="CLU_023861_0_0_1"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="35"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="248"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="421" mass="47455" checksum="F90261F154FB5502" modified="2015-04-29" version="1">METGFGIGRVRYLWSLRGIHIADCLGSWVDRPIRPISLRQLFFFGRTLTESRLLSSANYVRMELPTRIAHRLREMQRLPYVVVTNPHLSLVYELYYKSFENFRRIPVIRSVEENEQFCKVIGESLKEHLAVIPNLVMGVLECQDLVSADTMDKFVQAMLRARISRRVIAEQHLALTDTFNSPWHVAQPSAENEFVGEVLLKCNAKDVIERVGKFTQDICKSSAGADPLVPEIKIQGHVNATFPYVLSHLEYIIGELLRNSVQAVMSRYQTPNNPPPPIEVLVCEAPQQVVIRISDQGGGIPREITPFLWSFNKGPRSASRLENFRDVPTLAATMQEVRQFAAAEERPSGKMRDSSLSTLASRAPDLRLGMGLPMSRVYAEYWAGGLELHSLEGYGVDAFLQISKLGNQNEQLTSRASIDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YH73</accession>
    <name>A0A0D1YH73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_07088</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234522.1">
        <property type="nucleotide sequence ID" value="XM_016381420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YH73"/>
    <dbReference type="STRING" id="91928.A0A0D1YH73"/>
    <dbReference type="GeneID" id="27334171"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07088"/>
    <dbReference type="HOGENOM" id="CLU_018830_0_1_1"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11854">
        <property type="entry name" value="SH3_Fus1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035521">
        <property type="entry name" value="Fus1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="434"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW14306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="663" mass="66555" checksum="9521395342023A16" modified="2015-04-29" version="1">MGHAHHQHFHDRMVELARRQDGVSTDGGTVYSVVYVTAEPTFTGVIGGYTTLSAGSNSIPAVATASTGGAQDAGTTGASVEFSTAPAETVVVTASASNSFDTAAGAATTAATTGPDSVPSASVSTTLSTNNVAAFTSSGASSTGAVSQKDSSSGSSGGMGTGAKAGIAIGVIAVVGIIAVFLLWLLGKKKREREAQANKDNEKSTYGAGAPAATELINRSPTISSTTAPRLSLRPVSRMLPEFGQPNKARLSGGNLLNTAGAPGAASGRNLSPSPQQPRGPSPARSPVLRENPFADPENSEKPENPFADPEKAVAGPVHAVSAPGAVPTPPAPAPSATPVAAATAALGGVATAAALQAKSTPAPGPGPVAGRSPSPAQAPAVNSGSAPQPPVAATPQPQVATRDSSAIGPSTPVTSAPIAAAAAPAGSPASEPPQGNVYRVLLDFVPSMDDELELKNGQLVRLLHEYDDGWALCIRLDRSQQGVVPRTCLATKPSKPKPSHLNQYARPAARGPGPASRPMSPAGTPRSQYFNSPRPGMASPARPMSPAGRPMSPAGGPRRPMSPAGGPRRPMSPAPMSPAGSMRPSRSMSPGPGQFNQAPRPLSPGPGPQQKRSMSPGPSRSSPMADVTRRRSNSATIVRDKRNSPIGPSKLGLGPSAPGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIN9</accession>
    <name>A0A0D1YIN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235017.1">
        <property type="nucleotide sequence ID" value="XM_016381915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIN9"/>
    <dbReference type="STRING" id="91928.A0A0D1YIN9"/>
    <dbReference type="GeneID" id="27334669"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07586"/>
    <dbReference type="HOGENOM" id="CLU_015054_0_0_1"/>
    <dbReference type="OrthoDB" id="4508363at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="648"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="952" mass="106142" checksum="B2B558794A0D6756" modified="2015-04-29" version="1">MSLLFSGFLPDPASLARISDSILARLEKSAVKETQTSQWLLSSLSQRLRCINQALSRRSRNESADSDYLRFLEETLKLCEQSLAELNNLTKSSVPVDGAAGEPVRNAKPDAGAGEANAMEVGTQRMRNITQKLLDYTNTLTLALHWFAIECDVSPTIIRQLQSRLDASCKWLYDREILKPIRPVSSSANHGVTFRLEEAEWMTRTSLPPRRTFQLVCPRASLPKADSAEGNLQFVCSCNADHSSSLLYKGSISCHNYMTLRSHVAVFKERLIPVEETGSDSDPTWEMLLLKPNALVTVRLSNLQPTHFAQLESLSSRWAALLLRSAEIDRSSEVLKVSEDTVSVLRVKAYNSTISLNVKTAAVPKLRTQSVKFVSGGTPRTYFNVPWKLGYLQIFQYASVSKELLEASEDSPCTSIFFDEPHFFIFFSERHPMSKTAKTQPLDRFMVQGKSLNVVITDVDCIHEGRATTLQRCSEIHFEFCDNKEATVFLRNIQNMQNRLLEKSLQKPLWGETVVYQHASDILPSGTARLLGAHASLVYNPSAPRAKYRLIGIQNAETWPARIDPSHFVWTIYRADSGRMVVNRQTWEELEDSPRPPTSPRPVHGPGPAISRINEMSSVNWFDELEKVTLVLKAPKNLAEKDTQYNPVKIAVIDTGFDSNPSHKARRQIIKYKDFVIAPRSPDGKGIKDKANMGNPDEPLDPMKDLTGHGTTSVELILKVYRDAALYVARIFKSNQADEEIEPYLMADAIAWASKHHVDIISISAGFKNAPKELYDAVVRAATNNVLIFASAANWSFSSPAAWPARIPQVFAIFSTDAGFKNSRTYNPPSIANAHNFAFLGEDIRSSPEKEPVNGTSASTAIAAGFAARIVDFARQPGCRGAFEDVVQPRSHMGMTAIFKALANMDSEYECIRPLRLLDQARKRNDPDDRAQNRARVLEYLVGIMEGALGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJ13</accession>
    <name>A0A0D1YJ13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235142.1">
        <property type="nucleotide sequence ID" value="XM_016382040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJ13"/>
    <dbReference type="STRING" id="91928.A0A0D1YJ13"/>
    <dbReference type="GeneID" id="27334796"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07713"/>
    <dbReference type="HOGENOM" id="CLU_003736_0_0_1"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="223"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="527"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="804"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="914"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="933"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="949" mass="107353" checksum="095A278ECFC69CC1" modified="2015-04-29" version="1">MADPRSTRIEGTLTSLFESLVPPPNIDQDDTETEYRIDRAIQNAKDIVLNADSRLPSDTNQAQDLIKRKLLRENASPEKAARFSNLYSRLLAIPVLNQKWAILYLLYKLSDASVLDVHPRDPLADSAHFANIPRRHTLSSAKPYQVDEQAYDDGGGDDDDDDVASAEVPFPRGRTIPPKAKADVKVEKELPAQEAQSTEEEQEADPVQPMKERLVSPSEPELLRDLPFNLQGVSSTHVEFTGVTSLKLPTTLPVPIISLLHALAEPCLLYRGLAEYTNGQEGGLIDQSLRSAINNELRSYLSLVASLESEIRQALAALSQSEDPQSLRVTSVTLKRCMIWTRDATMGLRLMKLIVEESQQKRGGQLLSLIHSLSSSHGDPFVASFAEKLLAHVARPFYEMLRHWIYDGELVDPFHEFFITEPDPNVSQAVDHRHVATSVWEEKYKLDTAMVPSIISSEFSKKVFLIGKSLNFIRHNCGDSDWVIQYSKSNSKSLDFANTANLPMSIDVAYKTTMSRLTHLMSTKFGLFTHLNAIKKYMLLAQGDFIDLLIESLAQHLDRPVNSMYRHNLTSQLEHAIRHSNAQYDDPEVLRRLDARMLELSSGEIGWDCFTLEYKISAPCDVVITQWANTQYLKIFNLLWRIKRVEFSLNTTCKRCMTGGRGVLAGVNDKLGRDWKRSMCVVAEMVHFINQLLYYLLFEVIEASWKQLEEAVHKPDATLDDLIEAHTNYLNNITKKGLIGQQRHPITGQQEDSLVAQVHHILKCMLSYREVIDSLYKYSVAEYTRRQQFNAKVEQRTAQGRWGITEKDLNGDTRASTPASLAPSKTGRRVQLLPEEGDSPLVGPVGSLAPGDDETQLNSLRARQLHLSAEFRSRLSMLLYDLAHQPDVDLRFLGVVMNFNEVYQPVNVRRQQARRAREKRELERKAREAAVSSEANTSMEKDMNSSTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJC5</accession>
    <name>A0A0D1YJC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235247.1">
        <property type="nucleotide sequence ID" value="XM_016382145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJC5"/>
    <dbReference type="STRING" id="91928.A0A0D1YJC5"/>
    <dbReference type="GeneID" id="27334901"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07818"/>
    <dbReference type="HOGENOM" id="CLU_450566_0_0_1"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06262">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="577" mass="63078" checksum="FA0F335C5E13011C" modified="2015-04-29" version="1">MAMAQEVPADFSDLPLSCPYTISRLLTAAGEPSATWLIRERDQYGEYPHIYAKVCEGVEAATGAKGQPSTYKVIVLSDSGCGTEVINDISPPPVRRTEGEKDDDHVVSRSRRSEPSRWNIHTFLLYTLNPGGCIPYMVITSHCHYDHITGIGKLPPTGGYDHEHVSSTSTSSDKTQDGADRLRTTVLTSSLHKSFVTPYANLQEHSLSASVGLQAPRYSITWAEDLSEATWRWTRPAQKDAGISAAEVAIGARMTMIQTPGHTPDSLSWYDEDLALLFVGDSFYVKESPETRSAPWGPEPPMPTMFDVEGDLADMWESIKKLLRFVRVKNEELKLNHDKHRATTDTVTTTAATDGGGGDDVQKNMIPHGECENGRRRGGLTKRHPSTWYEAIPFFRSRGLAASQSQLGSQSHLPVPHTRYTDDGWVMVDSHPGGGRGGATTPSSQAPPRVQLAAAHTTAGGVDAEAAILSFREFLVLILRDEVPKKRVADGFRGHETWLYDFALEESGGGQVKEEIDDGDDDDADPDAGIGPLSYLRQYSVQAPLTVIEEGKKRISEQEWMGMSEPSSSSSSSSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMV7</accession>
    <name>A0A0D1YMV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TFIIE beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06432</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236597.1">
        <property type="nucleotide sequence ID" value="XM_016380770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMV7"/>
    <dbReference type="STRING" id="91928.A0A0D1YMV7"/>
    <dbReference type="GeneID" id="27333515"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06432"/>
    <dbReference type="HOGENOM" id="CLU_056580_0_1_1"/>
    <dbReference type="OrthoDB" id="5323195at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054600">
        <property type="entry name" value="TFA2_E-tether"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22254">
        <property type="entry name" value="TFA2_E-tether"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="8">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="231" mass="26781" checksum="AAA13C502F654647" modified="2015-04-29" version="1">MSAYLSSTQTSVAGSDARTNVIYALGRLKEKFPDRIGWNELVEYVLPQYRRTEEQIMYFRTFLSKNPKADHDPDTDTYRYRPEHNIASADDLLKHLQGQESAMGINVRELKDTWPDVEAAINKLEAQHKLLVVRNRKDNHPRTVWVDDPTLHVALDQEFKDIWSQIALPSEEDTIRELRRMNHKSTGEPARTDVVAKPKAKKKAARRGQKVTNTHMQGLFRDYSDKRPQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNA0</accession>
    <name>A0A0D1YNA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236737.1">
        <property type="nucleotide sequence ID" value="XM_016380910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNA0"/>
    <dbReference type="STRING" id="91928.A0A0D1YNA0"/>
    <dbReference type="GeneID" id="27333659"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06576"/>
    <dbReference type="HOGENOM" id="CLU_020027_14_3_1"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002247121" evidence="2">
        <location>
            <begin position="23"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="35"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S12 Pab87-related C-terminal" evidence="4">
        <location>
            <begin position="426"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="516" mass="56087" checksum="DAB4F234F773E194" modified="2015-04-29" version="1">MLVLPLPSILTGLLLPFCLVEAVSQQSVQQAVDRLDSFIQSVLNDTQVPSIAAAVVYNDSILYANAFGVREVGSNESATAETVYQLASLSKPISSTIVAQLVGNGHLSWTSKANELDSSIELSDPWITGEVTVEDFFCHRSGLFGNAGNDLEPFGYNRKEILSRMKFLEPTGSFRVDYQYSNYGITMGAVAAATAAGLSWEEATSRLYESCNMTSTSSEYDDFLQRSNRASLHIRAGNGTNFSEPYIRAPERNPDAQAPAGGVTSSVLDLAQWLRLQLGNGTRDGQQIVSSEPLQYTHQPQINRGPDPATNRSAFYGLGWNVDYSSSGIFVGHAGAFTSGTRSYVRMNVADGIGIVVLSNCWPTGVPDGITYTFLDWVYQGNRTGSRDWVSFWDDEYDELNENFGVSDPGLAITPVNASAPLEGEDVYVGTYFNDYVGAVSVSGTDNRNLSMQIGERTLPLTHWDRDVFILRPVLENPEYPTTVTFVVGAGGQAQQVLVEDLNGDGGGVLSRQVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQJ2</accession>
    <name>A0A0D1YQJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237702.1">
        <property type="nucleotide sequence ID" value="XM_016379025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YQJ2"/>
    <dbReference type="STRING" id="91928.A0A0D1YQJ2"/>
    <dbReference type="GeneID" id="27331763"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04680"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF11">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="261" mass="28996" checksum="0532639791F4475D" modified="2015-04-29" version="1">MPFPYKKVVVIGATSGIGEAFAHRLIDDGSFVIAVGRRKENLETLVQNHGHDKCQAVPFDITKLESVPHFATNIMNTHPDVDCIILNSGIQRRTDFSDPDSIDINSLQLEFNTNYIAHLALTKAFLPFLQKRSTESALVYITSGLALVPILRCSNYCASKAALHQWILCLRAQLSKTKVKVIEILPPAVQTELHDEKHQPDIKDGRQIGMPLDEFMDEAYSGLVRGQTQVPVGTSKRAFNGFEVKRQEAFAHMLKVMGSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVC2</accession>
    <name>A0A0D1YVC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239452.1">
        <property type="nucleotide sequence ID" value="XM_016377882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVC2"/>
    <dbReference type="GeneID" id="27330613"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03530"/>
    <dbReference type="HOGENOM" id="CLU_091760_0_0_1"/>
    <dbReference type="OrthoDB" id="4120664at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237241" evidence="2">
        <location>
            <begin position="34"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="265" mass="26725" checksum="CBE4503DB49BE3AA" modified="2015-04-29" version="1">MSTFGLFRQFSQSSKVATLLAITLLFAPHVAHAALALTFFEHSSCNAGTSFQSYNDPNALQADTSCHQLPNGTVALYVNQIDQGCTLRIYLSSDCSPLAPSPAGLLVPAGNCFFVEEGVDLGSWRPDCAGVDYSSSNGLDKGNSYNNNTNDGSADIYSALVTATGVVTVTAASSSSTTASSSSATAASIPGNNTTSGDGNSGGNATTTMTTTTTNTTTTGGSSGASQTSHSGSDSVRARAGDSVSTVMTMVVGMGMGVLALTALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWL5</accession>
    <name>A0A0D1YWL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239912.1">
        <property type="nucleotide sequence ID" value="XM_016374636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWL5"/>
    <dbReference type="GeneID" id="27327353"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00270"/>
    <dbReference type="HOGENOM" id="CLU_1165822_0_0_1"/>
    <dbReference type="OrthoDB" id="4161430at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="238" mass="25810" checksum="398B704091A1F882" modified="2015-04-29" version="1">MASLTLSISDVEATTLTTTAAATTAAAQASKVEVNLYRSAHLTPHLDHSHALGSTYPSSCATASRIINDLRRSQLPKAQSGLVRLIRAVHLFIALASKEWCKHTTDGNHCNGKTTPCHDEVGSSDDVHGEDETDNGATHGIDEARLIFMVKNSAVLQSIKIRVEIQRAFEEYCAMHDDEELDEKDGDGDGDGDHDGDTNDLIELPSTKHIRLEAQSLLGEFARNPLPDLADLLRGRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXN0</accession>
    <name>A0A0D1YXN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="12">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALA1</name>
        <name evidence="15" type="ORF">PV08_00576</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="12"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240217.1">
        <property type="nucleotide sequence ID" value="XM_016374941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXN0"/>
    <dbReference type="STRING" id="91928.A0A0D1YXN0"/>
    <dbReference type="GeneID" id="27327659"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00576"/>
    <dbReference type="HOGENOM" id="CLU_004485_5_0_1"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="14">
        <location>
            <begin position="12"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="808"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="724"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="728"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW20001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="962" mass="107696" checksum="B5864AD21C37129E" modified="2015-04-29" version="1">MASTTADKPHEWSAPVVRDTFLKYFEERGHTFVKSSPVVPLSDPTLLFTNAGMNQFKPIFLGTVDPTSKEGQYKRAVNSQKCIRAGGKHNDLDDVGKDSYHHTFFEMLGNWSFGDYFKKEAITYSWELLTKVFGLEPDRLYVTYFEGNKAGGLEPDIEAKEIWKSVGVAEDHILPGNMKDNFWEMGDQGPCGPCSEIHYDRIGGRNAAHLVNQDDPNVLEIWNNVFIQYNREPDKSLRSLPNKHVDTGMGFERLVSVLQNKMSNYDTDVFTPIFARIQEVTGARPYSGKFGDDDTDGIDTAYRVVADHVRTLTFAISDGGIPNNEGRGYVVRRVLRRGARYARKYFNVEIGDFFAKIVPTLVEQMGGMFKEIVAKEEEVKEILNEEEMSFAKTLDRGERQFETYAQKSKSQGLKSLHGADVWRLYDTFGFPVDLTRLMAEERNLSIDDNEFEAARLRAKEASKGEKKAALDLLKLDVHDLGELEKMPGVTKTDDSAKYGLENVTGTIQAIYHAKKFHPDTQSIPEGDQIGIILDKTCFYAEQGGQEYDTGRIVIDGQAELEVENVQLYAGYVLHTGYMKYGHFSVGHKAICEYDELRRWPIRNNHTGTHILNFALREVLGDGIDQRGSLVAQEKLRFDFSHKSGISDADLQKVEDVSTEYIRQNCPVYAKDVPLVIAREIAGVRAVFGETYPDPVRVVSVGVEVDDILKNVKDERWKTVSIEFCGGTHVKATADIKDLVILEESGIAKGIRRIIAVTGEDAHAVQRVAKEFSERMKKLEEMPFGPQKEQEAKALQIELNTLSISAVKKSQLRERMNKVSKELLDQQKKMQKEELKKATDTITEYFEKNKDAKAAVLRLPVGGNPKLVPDVVKHVQTKLKDKSVYIIIADASDPDGKVFHGCFVSPDGVKAGITSADWSSQVSNLVGGKAGGKAPVAIGTGTDQGKVDDAVEAARKYLEKFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYL3</accession>
    <name>A0A0D1YYL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Initiator tRNA phosphoribosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240592.1">
        <property type="nucleotide sequence ID" value="XM_016375316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYL3"/>
    <dbReference type="STRING" id="91928.A0A0D1YYL3"/>
    <dbReference type="GeneID" id="27328034"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00951"/>
    <dbReference type="HOGENOM" id="CLU_027654_1_1_1"/>
    <dbReference type="OrthoDB" id="45256at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007747">
        <property type="entry name" value="Ribosyl_Ptfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="1">
        <location>
            <begin position="350"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="51187" checksum="9067E3E32DC04A06" modified="2015-04-29" version="1">MTSSNFPTRLAELSLNDASIHPSIYASIRSLRKSVLSIPHRLTSILADAAFAKQVSEHYSLPLVANERCGSWYIDPADKVGSAYFKSTDGHHGQWSFSLRRLNLQLLPLLARYGGAVVVDSTRRGKNLPDAFSKTVPIWVSVVNRTLFPELTVTHILQLPPAPNDLGQSEASQIESRLDAFAKALQDLQLDFVGLRNEVKHPIRLQWAINGSFDVDSPHAGGPDARFPKEAHRLVLCSASRRVHGAEISEGGYIQGAGDDSEGWSHGLTAQVFWRHRQRLMSSSEEELPDIIDELMKGVHESDEPKAEEGTWIPPTQNLYVCAGTLDNADTYDLVIDCNGGEGAVNSKVVGLACRSGKLGSKDLREKLPSVAELVRSRLVEDPNARIVVTCTTGKDLSVGVAVAVLCLYYDDSGQVRDSLSVANPRVDKLLVKQRLAWISAAMSWANPSRSTLQAVNSFLMQRPEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZC4</accession>
    <name>A0A0D1YZC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Formate dehydrogenase</fullName>
            <shortName evidence="6">FDH</shortName>
            <ecNumber evidence="2 6">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_01228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 6"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240867.1">
        <property type="nucleotide sequence ID" value="XM_016375591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZC4"/>
    <dbReference type="STRING" id="91928.A0A0D1YZC4"/>
    <dbReference type="GeneID" id="27328311"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01228"/>
    <dbReference type="HOGENOM" id="CLU_019796_0_0_1"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="8">
        <location>
            <begin position="84"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="9">
        <location>
            <begin position="180"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="281"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="362"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW20651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="415" mass="45577" checksum="971699FB9517C355" modified="2015-04-29" version="1">MVFARVAARSLPRASSLLSSTSPHFARRAGAPSFHPSSIARRTLTATASRQGKVLLVLYDGHEHARDQPKLLGTTENELGIRKWLEDQGHTLVTTSDKEGENSTFDKELVDAEVIITTPFHPGYLTAERLAKAKKLKLAVTAGIGSDHVDLNAANTTNGGITVAEVTGSNVVSVAEHVVMTILTLVRNFVPAHEQIERGDWNVAAVAKNEYDLEGKVVGTVAVGRIGERVLRRLKPFDCKELLYFDYQPLKPEVEKEIGCRRVEDLEEMLAQCDVVTINCPLHEKTRGLFNKDLISKMKKGSWLVNTARGAIVVKEDVAEALKSGHLNGYGGDVWFPQPAPKDHPLRYAKNPWGGGNAMVPHMSGTSLDAQARYAAGTKAILESYFSGREDYRPEDLIVHKGDYATKAYGQRTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZR4</accession>
    <name>A0A0D1YZR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241027.1">
        <property type="nucleotide sequence ID" value="XM_016375751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZR4"/>
    <dbReference type="STRING" id="91928.A0A0D1YZR4"/>
    <dbReference type="GeneID" id="27328472"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01389"/>
    <dbReference type="HOGENOM" id="CLU_111196_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252330" evidence="2">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="186" mass="17452" checksum="96F2E39041A64B43" modified="2015-04-29" version="1">MHFSKPVFVAFAAVASAQDIGSIVSSALSVATSAIGDGTSVAGSVISDAASVISSVASSVPTQVESAVSSALSDAASIESSAESLASSLASSAASEAPSVRSSVDSQISSILSSARSAESSAVSVANSAASSFISSRTAAAGSASSAAATATSTSTSSTGNGAAGTYVVPAAGMMGGLLLALVAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZDN9</accession>
    <name>A0A0D1ZDN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231323.1">
        <property type="nucleotide sequence ID" value="XM_016384721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZDN9"/>
    <dbReference type="GeneID" id="27337490"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10407"/>
    <dbReference type="HOGENOM" id="CLU_997649_0_0_1"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15251">
        <property type="entry name" value="TAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="267" mass="29166" checksum="6C6A19A7DD03AA8F" modified="2015-04-29" version="1">MDSMRSLNTSLPSTRPAPPEQLLQAFRNAALSVTNLYKSAVTDQGSARQAGYQEALEDLLSFLDRENLGLQDGEGWRVRQWATERYDGSASHQQGAEDDDDRSDIEPRHRSVSPAKEEAPAPLIPTRTEAPKVEHSTQTEEPSPARGSEQTSTPVFHFTGATSSNESDNMQTDENVQGVEHGADNTPSSSSGPAIRLELLNNYGSRAPHRHGSQRNANRPNNREFTFTSGTKRKLQFPDFFDISNIGPRDGFGGGAGTGSNKRGRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZF53</accession>
    <name>A0A0D1ZF53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidase FUB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Fusaric acid biosynthesis protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10903</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231818.1">
        <property type="nucleotide sequence ID" value="XM_016385216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZF53"/>
    <dbReference type="STRING" id="91928.A0A0D1ZF53"/>
    <dbReference type="GeneID" id="27337986"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10903"/>
    <dbReference type="HOGENOM" id="CLU_020639_0_0_1"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="307"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="330"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW11602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="389" mass="42406" checksum="D6AC2F7CEFB4D7F9" modified="2015-04-29" version="1">MSGGAPIPVAVKGHEILCLEDIKERADANLPEMAREFYNSGSTYQTTIAENSSAFGKYRLLSRVLVDVSQLTTQTQCLGRTVKFPLGVSPAGLQAMAHPDGELATSRACAKMGVNMGISSFANYTVRQIVSAGQAQAEADGVELGGPHYAMQLYMMRDRAKQERIIAAAEDAGCKAIFLTADSPVLGVRFNEWRNDFRTPDGLGFPVLEWTSEAIRQASHDTAFMSFNDDTHSWARDIAWLRSRTKMEIWIKGIVAAEDVELAIQHGCDGVLVSNHGGRQLDGVPATLDALVECVDAAKGRIPVHMDGGVRRGSDIFVALALGAQHVWVGRPAIWGLGYKGQEGVEKMLAVLYEDFRRCMALCGCRTVADIKRSCLRRMGVDGVLRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZG89</accession>
    <name>A0A0D1ZG89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_09256</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232198.1">
        <property type="nucleotide sequence ID" value="XM_016383575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZG89"/>
    <dbReference type="STRING" id="91928.A0A0D1ZG89"/>
    <dbReference type="GeneID" id="27336339"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09256"/>
    <dbReference type="HOGENOM" id="CLU_015166_14_3_1"/>
    <dbReference type="OrthoDB" id="6703404at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="208"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW11982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="310" mass="33649" checksum="A72C0D11F2C76AE6" modified="2015-04-29" version="1">MSTTTGAFIAGGIAACGAVTATHPFETVKIRLQLQGELQSKDLAVKKYKGVFHGVGVIVKNEGIRGIYRGIGCAYVYQILLNGCRLGFYEPLRAAGSKLIFKDTNVQSLGVNIFSGAASGILGAMAGSPFFLVKTRLQSYSPFLPVGTQHKYRNALDGVRQIYTTEGVRGLYRGMGASMVRTGAGSSVQLPTYFFAKRRLMRHAGMEDGPALHLLSSTASGFVVCCVMHPPDTVMARLYNQHGNLYSGIFDCLYKTIKTEGLLSVYKGFTAHLARILPHTILTLSLAEQTNKFVRGIETRILPEALKDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZGF2</accession>
    <name>A0A0D1ZGF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232258.1">
        <property type="nucleotide sequence ID" value="XM_016383635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZGF2"/>
    <dbReference type="GeneID" id="27336399"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09316"/>
    <dbReference type="HOGENOM" id="CLU_602746_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="454" mass="46269" checksum="5617089E14A31BBD" modified="2015-04-29" version="1">MNNLVVFVVAAAAMAVFPTCFGVGIGIGVGLPLGLGLVAPGSSSAAWALEAIVAINTTSSSSSTAVATTTAPASSASSSVTLKSTVDPIVVPTALTTLPTGSPLPTTLETITILEVPVPIPIPPVTVILTDNATTVTVVVTSTLLSTVSPSPSPSPSSLPPGSPHTSTSGSDSQNESGNQRLSTGFIVSTIFASLGASWFIFCVVILLVLRHQQHQKDRRRDEFAAAATTTTTPPPQPIHRQHDEKGDDYTDTINLDHHHHHHHHNSTAMTASLGSPSPAAPSPTLQSTPVDAPSPPRALNRRRTRPHLWLGHRRTSSGLMAIPPSPSPSPLPPPSPAPAPAPASASASAVASTSDSVSMFASASVVRDTAAGGGGGGGGGGSSSASASASSPSFPPAVAAPSTIMSPEEIERWARFGDDINPQCDEYWSILSFGDASEAFGLVERPVGVRHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZGH5</accession>
    <name>A0A0D1ZGH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PV08_09341</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232283.1">
        <property type="nucleotide sequence ID" value="XM_016383660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZGH5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZGH5"/>
    <dbReference type="GeneID" id="27336424"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09341"/>
    <dbReference type="HOGENOM" id="CLU_000288_54_0_1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
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        <property type="entry name" value="C2_fungal_Pkc1p"/>
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        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
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        <property type="entry name" value="Protein kinase C"/>
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        <property type="entry name" value="Protein kinase C"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
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        <property type="entry name" value="ZF_DAG_PE_2"/>
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    </dbReference>
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    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="22">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
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        <location>
            <begin position="173"/>
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            <begin position="846"/>
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        <location>
            <begin position="780"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="17">
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            <begin position="81"/>
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        </location>
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        <location>
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        <location>
            <position position="875"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00012429"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
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    <sequence length="1171" mass="131179" checksum="991E26E4940BAFE5" modified="2015-04-29" version="1">MGDTEKAIDDIYKKIEREKTLITAATHMRQSTNNAAVQARVDSTIRDGRRNITYLEDKLQELQLRQRGAYDDGAPPPPAHGGNGGGGVGGGYPPSDGRGQRGYQAGNAPTPPPKDARGYFANERGDYGDPGPGGYSQGNTGMMPPRAIYGDPRPYNTPIPKARPNFSKLDLIKYDTPYLGPKIQLMLSQLEFKLSVEKQYKAGIEKMVRLYQDEGDRKSRSDAEGRRIESTQKIQLLKQALKRYMDLHVDIETSDAADDDSLNAPNMRKPLTGHLEMRIHAIKDVDHAASSRFSRGPETFVIMKVEDNIRAKTRATRTDKWTEEIHNVDIDKANEIELTVYDKAGDRPTPIGFLWIRISDIAEEMRRKKMETEFQQNGWVSADKMANGGSPGKPGTEFQQQQPQQSQGTPFMPPGNAAGAGSAAGFAQNPQQAQPVMIDSWFSLEPAGRIHLTMSFQKQTGARRPFDIGLNRQGAVRQKKEVVHEKQGHKFVKQQFYNVMRCALCGDFLKYSAGMQCADCKYTCHTKCYPKVVTKCISKANYETDPDEEKINHRIPHRFDNFSNIGANWCCHCGYLLPLGRRNAKKCSECGLTCHAQCQHLVPDFCGMSMIVANEILETIQRTKHHNKSSSVSSGMSSRTLRPNSGRPGPQSPTQSYVSDGSTLTQSVSNQSYDQHPEPPKPSAAAAAAAQNLMYNQPPRPQSPQQQRPLQQRAVSTAAVQAAAAATSRPSSQNYNQGFSDYSPQKVASDRYANARPPVPEVQPPHASYDPRAYQQYDRQPVQQQMMQHQQPQQAVVPQQRPPPPPQTQQSYSPAPIKPAPQHQQQQVATPPSGRGSGPRIGLDHFNFLAVLGKGNFGKVMLAEAKSSKKLYAIKVLKKEFIIENDEVESTKSEKRVFLIANKERHPFLLSLHACFQTETRVYFVMEYISGGDLMLHIQRGQFGLKRAQFYAAEVCLALKYFHENGVIYRDLKLDNIMLTLDGHIKVADYGLCKEEMWYGSTTSTFCGTPEFMAPEILLDKKYGRAVDWWAFGVLIYQMLLQQSPFRGEDEDEIYDAILADEPLYPIHMPRDSVSILQKLLTREPELRLGSGPGDAQEVMSHAFFKGINWDDIYHKRVPTPFKPTVKNEKDTSNFDQEFTSVTPVLTPVQSVLSPAHQEEFRGFSYTADFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZGL4</accession>
    <name>A0A0D1ZGL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232328.1">
        <property type="nucleotide sequence ID" value="XM_016383705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZGL4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZGL4"/>
    <dbReference type="GeneID" id="27336469"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09386"/>
    <dbReference type="HOGENOM" id="CLU_319335_0_0_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="673"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="785"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="553"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="899" mass="100318" checksum="E829D674B8C97805" modified="2015-04-29" version="1">MDPFSITSGALQIAGACAQVTITIIKWVGDVRTVDARISSFCDEVAALQTTYEGLERSLSSPLVAEAARVASKTSDGSHLWRQIKETLDDSRRTIQRVNDILDNIVRTSGFGRKFRAHLQESLSSGELSRLRQRIQVFNTTLSLPIQMVCVMLQLEQRDLTSDHQASLDAKLTGLENSVKELVRSLESRSHSQSLSSATIVATDPEVLRPEDDIDTYITFAKKFLATASAAASTRSSLSTVSPGMEPDVLLNRRKLYTPELPQPLTERERLTQWIPEPSIAIGHAVDAEDDTEIHFMRTKRHLNLGQERVEKGNNAEAETHLRKAIALMEKHDFDGRISLHPADVVLMLADACVKQEKLEEAINLLKPVAAMREDIFPVAREVIETMTKPQLPPYQQVDKLQALAANHMLGQVFKLKSDYESAEDHALKAFMERRKELGPQDAKTLESVQLVIDIYRAQGDKEEAEGYEVFLLPTETSPKSVSREPSTSSLEEPLLNQRMMAFESKAAPVQPQPIHRNSLSSLAQRLRHFGRSPQASYTQFSTAGDLQRLSISRSTTLNNNPQDIDTEQPRNDCLRSFGSPSDASTHDRSMSIYDDDSVNTPSTGIIERSSRTIESTFLAISQLCAEKNLDRATKVALQFLDTYHSNVMVIRKMELEKNIRRGSGQGLARTGRGYAPLHFFCELKKEHAEEVHLLIQHGVNVNAVAYQAGYTESNPKNAFTALQAATDRGYSTITSLLISCKGIKTEVRNAEGFTPLMVACRRGHYAIVKQLLAFPLPTEFPHWHGNTLLHDAARRCDPKLVEMLIDFHPDLNARDTFGKTALMHALTLDDVIDEVERKGRDSRRCKTVKILLEAGADSTLRDNRTNLGIRDIAFKSKDPDLLTLLDRSPRVGVSELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHD8</accession>
    <name>A0A0D1ZHD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_09624</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232563.1">
        <property type="nucleotide sequence ID" value="XM_016383940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHD8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZHD8"/>
    <dbReference type="GeneID" id="27336707"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09624"/>
    <dbReference type="HOGENOM" id="CLU_002323_0_1_1"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="197"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="883"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="933"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1060"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="963"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1124"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW12347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1135" mass="123363" checksum="4ACD5C99DE0CCD28" modified="2015-04-29" version="1">MVGLVSAAGLVGFLSEPDPELKSFALKQLDSQVDLLWTEIANSLGAIEALYEDEDFPDRELAAIVASKVYYHLQEYNESTAFALGAGKYFNLDKAGEYEDTIISKCVDTFITLSAIRDPTLAAATAGAPPQLDNAFGQGGDGAASMSASLTSPVTPFSQSVLPSKSLLSRQNTVTFDPTQAGAHLLHDDSSEALIQQRGLQKALTRVVESLFEKCFQEKRYRQVVGIALEARNLGILRRVIQRAAEDETKENGEATKTGQELMDYVLEICMSVVQERGLRNEILKMILELLNDIPSPDYFAIAKCVVYLDQHSLASNILRQLVNKGDARSLAVAYQISFDLYDNSTQEFLQKVREELAEMLPKEDKASDSDPSSADKMVEDKAEDQLQQELQDSAGAPAPSKPSITPEQQDAVKKIRDILDGLTSIHLNVEFLHKANRVDYSILSKVKDSLEARYSIYHSAVTLCAGFMHAKTATDSFFRQNLEWLGKAVNWSKFTATAVFGVIHQGNINQVHRLLSPYLPKAGGVTSSHDSPYSQGGSLYAYGLLCANHKGKAVDFIREKFKEATEEVVQHGGALGLGVAGMASGDESVFEDLRNVLWADSAINGEAVGLAMGLVMLGSGNTKVLSDMIQHAHDTQHEKIVRGLAVGMALIMYGRQEGADELIQGLLNDTDPTMRYGGILTIAMAYVGTGSNKAVRKLLHVAVSDVSDDVRRIAVLSLGFILFRKHTSVPRMVELLAESYNPHVRYGAAMALGISCAGTGLAEAIDLLEPMLKDPTDFVRQGALIALAMVLVQQNEAMNSKVVSIRKQMLKIISDRHEDAMCKFGCAMALGIIDAGGRNCTISLQTQTGNLNMLGIVGAVVFTQYWYWFPLAHFLSLSLTPTAVIAIDQKLEAPVFKFHCNTRPSLFDYPPEQVTKADEAPEKVKTAVLSTTAQARRRAAKKEKQQRRDSMDVDTATPVTPKVDKGDKMDTDESAAKEDEGKKKEGEATEVKKKAEKEKVGYDIPNMSRVLPAQVKYLTFPDQRYQPVKQATGGVMVVLDTEPEKERETIPLLVSKVEPPTAPAAGRTTGGATGAGTGTATQPIPETPARQITGSGAAAAAGVLTAIDEDEEGTEEAPCPAEFDYETDSEEQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZLA3</accession>
    <name>A0A0D1ZLA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233808.1">
        <property type="nucleotide sequence ID" value="XM_016383105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZLA3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZLA3"/>
    <dbReference type="GeneID" id="27335864"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08781"/>
    <dbReference type="HOGENOM" id="CLU_021251_2_0_1"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="110"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="609" mass="66520" checksum="F553EC1241F0FA28" modified="2015-04-29" version="1">MSYGSRALHSSSECYHDLLSAFIRQTRPHTRTRLRDSSQQREFHDYFVTHLPSSSLHPDSRSLTGLAHKFPRQESTPHTPDGGRIAPAAHPSVLRDTTVVRIPLKSAKHHYGASVSRGSRPYNEDSHQAGVIELPAFAKRPPRSITARSRPGEGTSAEGASGDPQVFYFGVFDGHGGAECSDFLRERLHEYIEKSAESFELQSSLQKPGERKSKPVAAPARSVLTAEKEEQSKGGRGPSPTTEGQAPKQGEGQSAAGSPKSPSKDQQRPYPGDAPLIQSANRQQIKTLETELTKNWKELVGGYFRRFKPAYFSIFSGYQKLGEESQSLQMVGQGVDTGAAIEEVISYAFLKADYDFVSAQAAKHSESRDNTRADRPLNEGDILGEPFRLAAHIGGPKRFKGGSTCSIALVSTPSPTPFWNASTTSSLLVAHVGDTRILLCSTDTGAAVPLTTNHHPSSPIESNRLRRYAATFVTDSFGEERISGLANTRAFGDIESKRIGVSAEPEIKRVDLGPAEYSFMVLMSDGVSGTLEDQEVVDIIKEARTPEQAARDVVNFATEVSTEGDNATCLVVRMGGWERRQEGGYGSLGTKESRDWKRQSASDPRSRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQT6</accession>
    <name>A0A0D1ZQT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235378.1">
        <property type="nucleotide sequence ID" value="XM_016379551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQT6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZQT6"/>
    <dbReference type="GeneID" id="27332290"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05207"/>
    <dbReference type="HOGENOM" id="CLU_006329_2_2_1"/>
    <dbReference type="OrthoDB" id="4451586at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="183"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="645" mass="73244" checksum="1B9B016C93CB9463" modified="2015-04-29" version="1">MALEPGRQSDPAHLQQQSTGQSFLQPPSARNNGFSWPNLPDYIKPLPVSLDSDDIEYLQKKGAFTLPDRPLMEECLRCYALYIHPLYPTVNVIEIQSILNDDKDGEAISLLLLQSLIFAGSMWADVRLVRNAGFLTRKAFRQSWHQKIRLLYDMDYEEDRHCLVQSLLLWSFWWRSINERKDSWHWIGIAYSIARTVDLHQASLGGINASLAQRKHQRRLWWALYTREIIGSLGMMRAPRIKPGDYNVAMLCTEDFDSDEGTTEVLTGLSLPSKEQHQALTRLTIDFTKLIYIFGRILTTACPENAAGRTAVLYSAQQMEGSNQVLSKRQLNIEELKNCQQQLMTWRQELGRDLWRAENLPFDPPAWSRSELCHRGLLAMLYHLALMTIHRPQMLSTEESVTSSRAIVRSCAQEITKIAMDFFRADLIKCLSATAVSCLMPASIHHVFDTFSEDIKVRSEATRQLEECRVMLHTLSEQQFASAWILQTIQHIIDRIKVPSRTEKVSWHPRVTDSRGVASSSYDECITPRSRGEVCPEGSATDEDQTHNFPEFSTVTEDPAVRSLPDVRTANDCPESRTVLDACNSREDWAASFWNAPDAGPMAQLPLPSDALVPLQPDLANTEALADMWMDFAFVPDNMSGLPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTA5</accession>
    <name>A0A0D1ZTA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_06048</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid-expressed genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236213.1">
        <property type="nucleotide sequence ID" value="XM_016380386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZTA5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZTA5"/>
    <dbReference type="GeneID" id="27333131"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06048"/>
    <dbReference type="HOGENOM" id="CLU_012842_1_0_1"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000458">
        <property type="entry name" value="pH-response transcription factor pacC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001875">
        <property type="entry name" value="pH-response transcription factor pacC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="361"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="471"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="558"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="364"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW15997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="608" mass="66052" checksum="3D013D5F0408B67A" modified="2015-04-29" version="1">MSELGDSSTTPNPPAPQDVPAVSQPQQQQGQLPQQPLLQTPQQPAPSVNAAGENLQCQWQGCGERCTSAEALYEHVCERHVGRKSTNNLNLTCAWGQCRTTTVKRDHITSHIRVHVPLKPHKCEFCGKAFKRPQDLKKHVKTHADDSVIMRSPNLDANGGQRSQNGMPSGADYNASYYGHALTGQVGQNYYAPAIPGPGDYTGQHHPNQYYQPHPPVPTGQHPGYGPVTYYSTAPPTYDYETRKRGYDALDHFFGQVRRRELDPANFHHISRRLFELQGLQLPQIIPANVAVPAYQPVSVGGAYESEDPIQAYSLPPMGNAKTRGDLTSIDQILEQMQATIYENDAQMANTGVGQAGSGYVAYRTSNSPPSTAQVPTSAAQNNPASLLQHTHQGSIASTADASTPGLTPPSSAQSYTSGQSPLQNHAAPSSSALYPSLPSNASDMAYAAANAATLSGMFDNDERRRYSGGMLQRAAPDKDRDDMDIVTDGSVTPPASAINKGKKKAESPGDSVIDPALSAEIGSPKSDSKDPEPGEVWVQNMRLIEWMRELIKKRLESGQFDDDDDKALTPKADGLDHDMTGTDDHKLQDRSEEEQLYPVLRHVEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZV57</accession>
    <name>A0A0D1ZV57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Leptomycin B resistance protein pmd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_03790</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236818.1">
        <property type="nucleotide sequence ID" value="XM_016378141.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1ZV57"/>
    <dbReference type="GeneID" id="27330873"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03790"/>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="793"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="838"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="917"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="943"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1027"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1057"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="135"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="459"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="798"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1121"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW16602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1366" mass="149081" checksum="6AC74B462E8B5CFB" modified="2015-04-29" version="1">MNPSGQGELPAGASAIQENIEEKQRAELGIVTDREKDVKPPENDPSTPTHTSPGSPTSLDSPASSTSNAETPPDLKKYDSKIVQVRDVPEGDAALAHLPEDEQEVLRKQLATPPVQVTYKSLYRYATTWDIVFIVIAALGAIGGGAVMPLMTVIFGNLSGSFQGLVLGNLEEDFDSILVRYVLYFIYLAIGEFCLIYVSTVLFIYTGEHITAKVREQYLRAILRQNIGFFDKIGAGEVTTRITADTNLVQEAISEKVGLTLTGVAAFFAAFVIGFVKFWKLTLICMSSVVTIVVVMGTGGRFMAGWNKKSLESYAVGGSVAEEVLASIRNAASFNTQDKLAKRYDVYLQDARRWGVRSKSALACMIGSLLCIIFLNYGLAFWMGSRFLVSGETTLAHILTIILAVMIGAFSFGNVGPNIQHFAAGVAAAAKIYGTIDRASPIDPLSDDGEKLEKVEGTVELRNIKHIYPSRAEVVVMDDVNLVIPAGKVTALVGASGSGKSTIVGLVERFYDPVGGKVFLDGHDISTLNLHWLRQQIALVQQEPILFSQTIRENIRNGLIGSPYENEPEEQQTQRILEASRKANAHDFISSLPDGYETHVGERGFLLSGGQKQRVAIARAIVSDPKILLLDEATSALDTKSEGVVQQALEEAAKGRTTIVIAHRLSTIKTADNIVVMQAGRIIEQGTHDQLLELKKAYYNLVSAQRIGGDDEDQSENEKGTDMSDDELLRVQTSRSGGDPMIDPEDEKLALGRTRSQKSISSKLLADRSSGGEPVYSLWTIIKFIGGFNASEWLIMCVGFVFTIIAGAAQPVQGIFFAKSIVSLSHPLTERHQIRSDINFWSLMYLMLAFVDLLAMVIQGIAFAYCSESLIQRARDGAFRRFLRQDIAFFDEDQNSTGALTSFLSTETTHISSISGATLGTLLSCTTTLVVAIAISLAIGWKLALVCMTALPVILGTGFFRFWTLAKFSATAQKAYEKSAGYACEHTNAIRTVASLTTEREVYHEYKKQLRLQLRASLKSNLRNSSLYAASQSAMFLAFALGFWYGGKLLVRGEYSLFQFFIVFSEIIFGAQSAGTVFSFAGDMSKAKNAAAALKKLYDRQPSIDPWSPDGERIADVEGTVEFRDVHFRYPTRPDVPVLRGLNLTVKPGQYIALVGPSGCGKSTTIALMERFYDPLSGGVYVDGKEISSLNLTDYRSHLALVSQEPTLYQGTIKENILLGADRGEVSDEVIIQACKDANIYDFIMSLPDGFATDVGSKAALLSGGQKQRIAIARALMRDPKILLLDEATSALDSESEKVVQAALDAAAKGRTTIAVAHRLSTIQKADIIYVFDKGVVAEKGTHHELMALKGRYRELVSLQSLEKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZVI8</accession>
    <name>A0A0D1ZVI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236953.1">
        <property type="nucleotide sequence ID" value="XM_016378276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZVI8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZVI8"/>
    <dbReference type="GeneID" id="27331009"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03926"/>
    <dbReference type="HOGENOM" id="CLU_013363_1_1_1"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="3">
        <location>
            <begin position="60"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="190"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="807" mass="90445" checksum="EF02A4C38E1DFA59" modified="2015-04-29" version="1">MEDDLATKASETVDRVEKELISTLKHKEPVYPRLEQQLARLRTACQDCIFASFELATTRKVESRLWDAHSKVNKTFRVFLARFREGESKKKHVERRKAEKLYLDFIKSSMRFYRGYVQRLASHFADIPEVFEVARKFNLDASSVDSSQPVDLALKRQIIRSCYLTLIQLGDLSRYRETELQTKERNWGPAKGYYELATTLDPSSGMSYNQLAVIALADQDHLRAVYYLYRAISAPNPAPQAEGNLKIEFRKVKSKLTQGKPLSDVASTSDANTDLLHRFLLFHARCFEAGFVDHGDLQSEILNLLANELQAKRSDNLLRKFCLINIAAEKYAADKAIAVGGGDIPSAAGSYQMLFHLNILTFTRLLKMLFEELQRHGPVRSDVLSVLCKRLLPHLRLYSDWFLTNVNYLLASSSSQTELSELWQIYAQTITLLIQRFAVPTIPDIAYLLEEDQDTLGFTPFQKSIGEERFHDSANDVKPVYSESTFGERSVENEMLYRIKGLVKDGLFLCQRTGQFEPDSNLTNAVPLVFAGKQLIYTGQGDLQTLSSMGSSIHINSSAGSIDVDNLDRVSSSLNAFSQRPAHPDGVSEAVLKSTMENMVIDLTEREEPAQFELQSDLSPRSMKTPYAQGFPRRSSQLSHGPDVMPEQTHSFRLSTGSLSGLPGQIGGRPIIPPVTHSPFTPTAEESGFSPRTGIVRRPDSLAFPAQLNSAVQFNAQIKHMQQQIEIMSSPLESFQPTMSSHYGTPTHLPSWSRIDETDKLPLSPWQDLGQVQRTGLSTRSPEPSPFGAIGEARPKSSRAPTSGQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0N3</accession>
    <name>A0A0D2A0N3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C6 zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238718.1">
        <property type="nucleotide sequence ID" value="XM_016377148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0N3"/>
    <dbReference type="GeneID" id="27329873"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02790"/>
    <dbReference type="HOGENOM" id="CLU_036330_1_0_1"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="52496" checksum="70421D15FC759E6E" modified="2015-04-29" version="1">MLHTSPLEPGHSTRSLVSSTFPTRYTQPNPPTERSSDISQLSVCALIGPAPQLGDWRLLRELNPSHVMSEDPFSLRLVQYYDHVVAPQMVWIDSSENPFRHVVIPLAIQTPVLMTSILTLASGDLRVRSHGIYASEFAVSSRLESYQEETLVRLARHLKDATEAPATTQTVADISPTAGNVLATFLMIYLSVKLGDVSNYRLHTRAAWSLIENWRLSLPLRVQPSMQGLRDFLLHEAYLFKVCVALSTFQPFDDPYEAASMINEDQPFMRYLKIILDLVEIEQSKRSRSHSRSHQRNFWLDLSVVALRKEFDAARERSLKHKFRVPVPPRIFEHLVDLFHYSGIYFGSQVLSHDQQSASFATSAHRSLLSLLRQVPDIKLVAQNLGWPVFFAGTGCHGSPDDISFVRIQLQEVIRLTGWSERRRLLRFLEEFWTLSDGGTPPSWIDLAQSYAFRGEPILIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0R0</accession>
    <name>A0A0D2A0R0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238753.1">
        <property type="nucleotide sequence ID" value="XM_016377183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0R0"/>
    <dbReference type="STRING" id="91928.A0A0D2A0R0"/>
    <dbReference type="GeneID" id="27329908"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02825"/>
    <dbReference type="HOGENOM" id="CLU_011099_5_1_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="254"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="670" mass="75395" checksum="558E37D46B055DD1" modified="2015-04-29" version="1">MGSAETRRIKQSTSSAWVSPERVNHTNDRIDNVESRLNQMELRMDQFIKGMSSKDTSTAAYQHHEPPQVSLPEEYHPDQYILDFDHINLDQVNQLLSQQQSSLPPSSEQIISSDYDLAADEPVPIVDSSYPSLPPLTTIQPAIEVYFAHQNSLIPLFSQSTFLRMLQDYYSFNSRYPRTAWAAINVVLALAARLPASPSNDLDLGPGDSQVAKNVNNALSVLAELVTGEVELLGLQVIIGLVIIFNALKDSRPAVVLIGMAVRLAHRLRLHIREGQDSLSVDEMLQRSRVFWITYIFDKDICLRHHTPSVQADGAIDVDLPSEHPPDDVGIVHTTDGRTSVNFFRLRVRLAYIQGRVYDLLFATQATKITPQERRARIAFLHNQLEQWRRTVPPELQANVVVNHVNRAALLWLCMMHFSYLGCLVMIHGIWSFDAEWRSRLTTRHDNIDVSIAANGQNSNLTTPTPPPLPRGWRNCVLMSRNCMVMISKMSLSDCSVWANGCAYFSALLILEANVFESPLDENVDSDLQLTGSAVGILNRMSEASTLMAMKRMNVVASELDRRARQVVHEARQNARAPRVRSDPRYQTPKMPLSSQTSPAQLQWDWANSGVEAWPGMDFSLKENTISLPSIDMFDIALGLGPFGEWNNVQMDNLFDTDHFAELTALLEPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A1E8</accession>
    <name>A0A0D2A1E8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239008.1">
        <property type="nucleotide sequence ID" value="XM_016377438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A1E8"/>
    <dbReference type="STRING" id="91928.A0A0D2A1E8"/>
    <dbReference type="GeneID" id="27330164"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03081"/>
    <dbReference type="HOGENOM" id="CLU_036511_0_0_1"/>
    <dbReference type="OrthoDB" id="3357271at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="477" mass="50058" checksum="A385D7ECF5755D2A" modified="2015-04-29" version="1">MSFRGVMKDGWHPKGKDGGKESWRGDFKGINQMAGWMGKGQDRNKKNEPEHISRPLSSLKDPAAFGPPPKNVNYHGGAALPNEITPQRSGWGAPLTQEQIASANRTANGPTEEEIEEEKRRAGPPLPYRADRTGLRTDHLPPPPVHRDVNRNADEVEPPQRAQPPKPAPGLPPRLPSRQNTSSTPTLPPTMAASPAPQAPPPAYEAATTDYSASQPSSNYGINQAAMSRLGNAGVSVPSLGIGSNASSNPWQNEQSQAAPVKSPSPKPPTQPQSSMNQLSELQSRFARMNSSSSAHSPTVSATPAASYTAPSQSPPPSQPAGTTWAEQQAAFRTAQNLHSNPSTVTAQDAAAAARTANSFRERHQDTISAAGAKANEWNKKYNVAGRLNSFLEKHSSPSSETPPPVNAPSPAPAAVPAPATSPELAASISRKPPPPPPPKKPANMHGSLNSMSGGPGAGVTSSPPPPVPLGTKPSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A231</accession>
    <name>A0A0D2A231_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfite oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239203.1">
        <property type="nucleotide sequence ID" value="XM_016377633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A231"/>
    <dbReference type="STRING" id="91928.A0A0D2A231"/>
    <dbReference type="GeneID" id="27330359"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03276"/>
    <dbReference type="HOGENOM" id="CLU_003827_5_2_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="6">
        <location>
            <begin position="77"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="7">
        <location>
            <begin position="267"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45002" checksum="5DA3FFF7FA2488E8" modified="2015-04-29" version="1">MGSPGDGTVEEPVNREPPAEELVQSSLTASKRPGTPDPEAYDRNHGPIQYINASTHKLAIRSEPALGSSDVLPTPIDVTLSMDDLGHKFRQHTVICALQCAGNRRNELRSRVKEVTGVDWGDGAVMNAAWTGPLLRDVLVDCGLSAKRYLKEYDGLHVQLECNATKVQEDEWYGSSVPLEVVVDPEREALLALHMNGTPLPARHGGPVRAIIPGIIGARSVKWLDTIIVSSRESQNHYQQHDYKILPAEATSPEKAEELGVWDSTPAMQDNPVNSVVTVPAHDGDEVKRDRHGRVRIAGYAIPHGKGGPVERVQVSIDKGNTWMDARILDDGDEKTTHPANKGKGDSRGKFSWVLWEVEDVEVQPAENVSIWSKATDRAGNTMDEKVPEGNWNLRGVGYNAVQGRTGVRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3Z0</accession>
    <name>A0A0D2A3Z0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239778.1">
        <property type="nucleotide sequence ID" value="XM_016374502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3Z0"/>
    <dbReference type="STRING" id="91928.A0A0D2A3Z0"/>
    <dbReference type="GeneID" id="27327218"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00135"/>
    <dbReference type="HOGENOM" id="CLU_016397_1_0_1"/>
    <dbReference type="OrthoDB" id="5586090at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="322"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="8">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="460"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="594" mass="65744" checksum="E039A407300615FE" modified="2015-04-29" version="1">MSSMSRSGPYASSADPSASQQAYDSNPPTFAAFSPTTTSGYSATSKQRSTIIVHKKSPLLVATPPQITRALAHSHPFLLPLNKLAGLLSWSTPDPWESFLLVAAFWAITLYGSAIIRFASPIIVVVGLILGMYSRRYSPLSSTSKTGEKHIKGHKREASETTSQHKTLDEIVDTLQELTARCNILLNPFLALTDFLSTQTTPTAATTRPALTTLFIRVLLVTPLWIFLTLPPFYILTTRRVVLTFGTIILTWHSKPARVARVILWRSVFLRKTAAFITGLQFDTSATPKDSSLLQSIARAKLKSQAGLASEAATKKRPDSSGVRFTFILYENQRRWIGLGWTTSLFAYERGPWTDEHLNPAPSKDEFELPEVEGGLSRWRWVEGSEWKIEHGDAKQHKRTASQSKTGPAGNAGKDTVDDGGGWIYYDNRWEEGKKEDGWGRYTRRRKWYRDAELVEATPSMDVSPLASPNPQLSDTEEEKVRRAKEFAKGIGASADAPEKPPISSNDQGNRVPKAGDDAAMSIKSATSKKSGGWFSKRERSDSKSSSGKNTGQFSTRSDRSRDGPEDDIHDRWQDTTVPHRGFSVSEDLAMSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A689</accession>
    <name>A0A0D2A689_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00882</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240523.1">
        <property type="nucleotide sequence ID" value="XM_016375247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A689"/>
    <dbReference type="STRING" id="91928.A0A0D2A689"/>
    <dbReference type="GeneID" id="27327965"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00882"/>
    <dbReference type="HOGENOM" id="CLU_009239_2_0_1"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW20307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="708" mass="79015" checksum="8BF9D051C6A1A7F7" modified="2015-04-29" version="1">MIHIDNDQLPSSPPKKRKLKHPRTARACAFCRRRKVRCTGTQPCDYCQNEGVRCEYSDGLVRSSPATPRQSSQSESQSLTVSGHSSTRTGHHAAVVDRPGYEVSNVPPPSKSVSLDPPQTFAQGQHIGPSAGVSFLYHIWNRSGTAEEEVSLPTAPLTCHGDAPQPPINMNQPLPTREEAITLVERYFQFAVPTYRFLLRPSTERWISQLLDGAQLSKAETACALIVCSQALLYTTVGDRYQNGGDEGLNRSRAYFDKAKSLLNQEPGPATLVSVQARLAMCLYLLGTFRINECRFSFSFVCTVLISIGLQRKPLPSSKFDLVTLESRKRTFWSAYVLDGYLSVFLGQPRLLHDADIDQEYPRNIDDNDLLPSESLDDLPLHGNLEAFIAHAELSKLMGRNNQLLYPLQPLTEEDVLARTYQMLSALDAWRDSLPEFLKPRDKTLTGQRTFERQNTTLKLAYAHLRILVTRRCLLADFSHLGRRGPSEGHRALKPIEECIAAVCTILDTIPVLNEKGTIYQAFWFQSYVALVGISTLYVFLIQRSRSRYLEQAFDRVDIYLDKARYCQDFLAKLAPEGSQSRRHHELLNRLRDRAVKDATRAKKAVAADGDNLANALRNTVDTETPEQQVSVSTDQAVRGGISDLIHPLNSEKVGQATGAGGYDGTMDAVIGQFTPAEDDFMFQDLNGWGWESLDTGGFFGDGDSFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A846</accession>
    <name>A0A0D2A846_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UNC-45/Cro1/She4 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241163.1">
        <property type="nucleotide sequence ID" value="XM_016375887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A846"/>
    <dbReference type="STRING" id="91928.A0A0D2A846"/>
    <dbReference type="GeneID" id="27328609"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01526"/>
    <dbReference type="HOGENOM" id="CLU_016305_0_0_1"/>
    <dbReference type="OrthoDB" id="5574718at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="3">
        <location>
            <begin position="231"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="837" mass="91154" checksum="F76EF4068A023277" modified="2015-04-29" version="1">MAALQRMTRKLSEERASGLAKEALELSLSGDKAQASRKLREAAALGHDNPDVQAAFLAIHNDQLGSPLRDLCRRYALYHDNTAGDEAVNYLKSSDASNAAPVALECLQIVLESLPTTLSSAQDFIIAELARQSQPVRQYFASELQVSTTEFFENVYERGDDAANCLRTIVLDGTLWRSEDDRLRVEDDLFQLFLAKLMETGHDHDGRALKGIALLLIADTQRLHTFIDGEAFEALMGSLDLRLPAEVRGQATLVLSKFFEVADSTGQDFLYTYIRKHVQRQKGDDLVLAFSASAHLFPVVPTMMAQLFLTEGFLSSIMPLLDRQFSNPIVHDAFLMLVNAACLDGACRTAIAQYCTSWLAHKVSNGSGKQPSLAATVLAKLRTSGARAGDQRANQADEDVSELVDLFKSTLVVEEGRNVSDSIEGLAYTSLKPEVKESLAKDAAFLKSLLDTLNSSHDSPEVVVGGLSIISNLTQYAPTLSEEQKRISQLKAYANATKPADPSPLENEDHVRARCSAVVEAGVVTTLVKLNKRRSPATSQLTDRILLSLSKNSKDRGKIAQEGALKLLILHAQKNLESPENHNASTDAAHALARVLISLNPSHVFVAGSTPHVTDAVIPLVALLKTPRGQPFSSDNPRDLLAVFESLLALTNLASAPEPSAANSIIKTAWDEIEELLLGNNSMIRRAACELICNLTVHPACAEKFADGSNRAGQRLHLLIAMADVDDMPTRRAASGALAMLTEEYSSVVAGLLEFDRSPEILLDLCQDDDAGVIHRGLVAVRNMVLCEDEEDKTLSTRARNAFKRHDAVEKLKACLKKTEDPTLLQIGVEALKSLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A877</accession>
    <name>A0A0D2A877_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241188.1">
        <property type="nucleotide sequence ID" value="XM_016375912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A877"/>
    <dbReference type="STRING" id="91928.A0A0D2A877"/>
    <dbReference type="GeneID" id="27328634"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01551"/>
    <dbReference type="HOGENOM" id="CLU_027722_0_0_1"/>
    <dbReference type="OrthoDB" id="4153769at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="72138" checksum="14BEB8248A03B6C2" modified="2015-04-29" version="1">MQEPPRKSKTFLWVNKDEASVSLSSSDRREKHRIFSFVQRQRSEGKIAGITDSRISRYDPALIRHPRPLRVRPSGHPSPSSIEDESSLQPVTDEGVKTRVQDTSPGRPRTSKEVDDFIRRHRFTIEQVSKHNWLPGSGVDPFAVTPFPITRHVEALIKYYWAFALTGAHNDKTEILPPHLQPVNQYTVIRDNAVQGAMHSRIRFAGIMVIMAARMVHISRIPTIGFPPPEYYLQLALHEVRGRMLECQDQGISADTTVLLAVHHLALAEWICQRYDVATTHLHAAKKLLPSKPSSHPSVAFAEEGIVNTDNLLCIETGRPPIFPVLYDPGPLEKARMTAIREEIMTRSQSRGVGTTMSMSAPSNGSFPDAMLPTSAFVSHQVDILLDASVILDWDLGSGFERALAADVIHPVLAPIIQDLLDVLTVAKYVWRTADASREDAHWMCKRARAFVHHILLLPTHPDLADFTVKSRKAEALRLAVLLVLIRCTNRVSFRATKPNMRRLQSALYGIDTDWTTENHFGLSSQPTPPSKGSSDSSPSPSVSPASCSTLSPLVGPFGPALRNLQTKQYDENELLLWILLTGHFNAQGEPEESWFLERATHVAQQRLGIDSYDGLHEFMGKYFYSKTQQLYSLRVVALHLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A9X5</accession>
    <name>A0A0D2A9X5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-1,2 mannosyltransferase KTR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241753.1">
        <property type="nucleotide sequence ID" value="XM_016376477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A9X5"/>
    <dbReference type="STRING" id="91928.A0A0D2A9X5"/>
    <dbReference type="GeneID" id="27329200"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02117"/>
    <dbReference type="HOGENOM" id="CLU_024327_4_1_1"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW21537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="49732" checksum="D8DBC25ACD92C320" modified="2015-04-29" version="1">MAGGSGRIARYLVVALVCLAIFYFVSTSSLSSYAQPLAEQAAEKFSWEKPNSDSSKAEYDAIADAFHSDASDGTSSVQDTKPLASLTPNITPLTPSELSPPAPGERVNATFVTLARNSDIWEIARSIRQVEDRFNRNYNYDWVFLNDKPFDDTFKKVTTSLVSGKTHYGEIPVEHWSFPSWIDQKKAEAVREDMRRRKIIYGDSVSYRHMCRFESGFFFRHPLLHQFEYYWRVEPSVELFCDVHYDPFRYMKDNKKKYSFVLSLYEYVETIPTLWDSTKKFIKAHPEHIAKDNSMGFLSDDGGETYNKCHFWSNFEIGNLDWLRSKPYIDFFESLDKDGGFFYERWGDAPVHSIAASLLLNKDEIHFFNDIAYYHIPFTHCPTGEDLRLKLRCHCNPGDNFDWKGYSCTSRFFELNKLEKPVGWMDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT74</accession>
    <name>A0A0D2AT74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl endopeptidase</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_11694</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230134.1">
        <property type="nucleotide sequence ID" value="XM_016386002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT74"/>
    <dbReference type="STRING" id="91928.A0A0D2AT74"/>
    <dbReference type="GeneID" id="27338777"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11694"/>
    <dbReference type="HOGENOM" id="CLU_011290_1_1_1"/>
    <dbReference type="OrthoDB" id="5049662at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="7">
        <location>
            <begin position="526"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW09918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="749" mass="82688" checksum="CD16CCD2524DD2A7" modified="2015-04-29" version="1">MAPQTTENPQVHRSDHVTIFQSVRHGSVSLADPYNWMTNLSSPETQAFIEAENKATIDYLSDAKLETPRERLQKSLLSLWKLPVVRELPKRLPTGDYIVRVAGRGSEHPRSYQISMDTLVDFKTPRHDPAVFHDESSSGGATMASSFSQTGKYWAFLASVDGSDSGVIRFKNVQSGEVLKDELSDAKLPYKPSSVISWMADEGIFYLHCPQDAESKVGIVPSTLRFHPIGAKQEDDEIIYRDPNRSVQTFKAHVSLDGELVFLDIYDKSRAGVVLAASVNGTRKPSDKLNLHFNMEVSRGISAEWDYIGIRPAAEVANLAKGHIFWTSQDNGKVVNYIPETATLETVVPSTPELTMVMARVIRGGHIAVVYSVDVQHQIRVFSPFGELVQTLDHLPFSTIIDLSYDADSASVLVLDNSFCDPPKLWSAQVMFDTRGSRAKILRFRPVNIFPLHHERDVRKSSPQTRQIFYDSADQTKIPMFITAQDTDDISSSAVVLLYVYGGNGISVIPHFRPDFSIFMDGFRGTLAVANVRGGGEYGHKWHAAACGKNRQRVIDDIHGAARHLRVELRASKVVLMGESLGALNSAAALVQKPELFDAVMLNAGPLDVLRRGDMGLGNIGKIELGDVRIPDEFDAMYDWAPIEHLQSGASYPPVFLVSGLRDKLVSAAHSCKFTAALKYTASLSGDGAASQSQYQQGRDGGATRSQSPVHLRIIQDLGHGGNSSTKTKALISMERWLWLCKTLHIEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATH9</accession>
    <name>A0A0D2ATH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230046.1">
        <property type="nucleotide sequence ID" value="XM_016386238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATH9"/>
    <dbReference type="STRING" id="91928.A0A0D2ATH9"/>
    <dbReference type="GeneID" id="27339014"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11931"/>
    <dbReference type="HOGENOM" id="CLU_009600_14_4_1"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF37">
        <property type="entry name" value="AMIDASE C869.01-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253914" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="73"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="575" mass="62995" checksum="23B3DC9F8FFFAD06" modified="2015-04-29" version="1">MVKLRLIFIFHVLLQVAHAFWGFSSADVFPLLQDANTTALFPMSRCGGFQLEEATIDQMQAAMSNGSVTSTQLVLCYLERAYQTQNYISSILEFNPDVIAIAQARDHERKQGKVRGPLHGIPFIVKDNIATKDKMETTAGSWALIGSIVPRDAYVVSKLRDAGAVLFGKASLSEWADMRSNNYSEGYSARGGQCRSAYNLTTNPGGSSSGSAVAVSANVIAFALGTETDGSVINPAERNGIVGIKPTVGLTSRAGVIPESEHQDTVGTFGRCVRDAVYALDAIYGVDLLDNYTSAQQVPNGGYTQFMTTKGALVNATFGLPWQSFWVYADEEQQNQLLELVELIRSAGATIINNTEITDYETIVSPTGWNWDYGSTRGYPNESEYTVVKVDFYNNINKYLSELSNTNMRTIDDLVAYNYANDGTEGGYEWPLGIPAFYSGQDGFLASLDSKGVMDETYFQALEFSQTSTRNGIDDALIVNGRKLDGLLVPPDVGQTYQIAAQAGYPMVTLPAGVRSVSGMPFGLAIMQTAWAEDKLIRWASAIEDLQQTSGTERKRTLPAWRGWLERNIPVIWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUJ1</accession>
    <name>A0A0D2AUJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230386.1">
        <property type="nucleotide sequence ID" value="XM_016385442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUJ1"/>
    <dbReference type="STRING" id="91928.A0A0D2AUJ1"/>
    <dbReference type="GeneID" id="27338214"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11131"/>
    <dbReference type="HOGENOM" id="CLU_104688_2_0_1"/>
    <dbReference type="OrthoDB" id="4487429at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="188" mass="21207" checksum="3A15EC62F0D09C3F" modified="2015-04-29" version="1">MLPNDERVDIQTSCPPLTYNYTERYNPRTGSFVFGYPSTGGVLIRGLGPVELVHLGLDRFKDATRSPDADEEDEFCTRLWRLGAQWWASRGEMEEALLRQDSGGAPQKKLAWTVETGWPSSGQGVWVLEYDVEDRAHYELRVGASLLNNCLDMDERCKVIENLGGTFYSNPDDCEALRPLSPEERTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUQ5</accession>
    <name>A0A0D2AUQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_11202</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230456.1">
        <property type="nucleotide sequence ID" value="XM_016385512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUQ5"/>
    <dbReference type="STRING" id="91928.A0A0D2AUQ5"/>
    <dbReference type="GeneID" id="27338285"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11202"/>
    <dbReference type="HOGENOM" id="CLU_006430_0_0_1"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="201"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="391"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW10240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="809" mass="87705" checksum="5AB8C038259B97FD" modified="2015-04-29" version="1">MNPVIEDEHYAVGGNRHSAAADWSLASGLLAFGADQNVALWSPLNDSGRGISALLSGHNSKITTVKFISLHDGSDELLVTGAADGNIWLWEHGSTWTRAHNAAAHQGSVNAIAVLKNSNIFATGGADSRVRLWKVQDGKLEALSTLELKPKFMPLALALGPFSATSIDSAFLVVGGTRNDIQVYSIEYLPSTPQVKLCATLTGHEAWVRSLALTAAADGEYFLASAAQDKYVRLWRFQPGDATSATVGPPVDSTRGATVTDTLTAKVQSVSAADSKYSITFEALLLGHEDWVYSAAWSPDESSQRLLTASADGSLSVWESDPASGIWVSVSRLGEISGQKGATTATGSSGGFWTGLWSPDGSMVTSLGRTGSWRLWQYNTDSQFWTQKHGISGHISSVNGICWSPDGGYLLSTSSDQTTRLHAEWKRGAKRTWHEFARPQIHGYDLNCITSTTPHQFSSGADEKLLRVFNEPRDIALMLHRLCHIPLPAEDKALPDTAAIPVLGLSNKAMDDAKDTQDGDAAEELGTDLTDDGLGASLPNVQEPPHEDLLSRHTLWPEHEKLYGHGYEISEAATPVDGRVLATACKASSIDHAVIRLYDTDRWNEIKPPLPAHSLTVTRLAFSDQPKGFLLSVGRDRQFAVFQNSDSDSKSWTRVAINAKAHSRMILDGTWLCNARRPTFATAGRDKVVRIWSGGLKDERLEFVCKISIARKVPVTAISAVVSGDAIILASGEDDGTVSLHLVKCTDEIELVKSVDIDKHLCPSKTINRLAWRPTQDTTEGSDRGHLAIASSDSSVRIWSINWRTWVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AV84</accession>
    <name>A0A0D2AV84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230844.1">
        <property type="nucleotide sequence ID" value="XM_016385900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AV84"/>
    <dbReference type="STRING" id="91928.A0A0D2AV84"/>
    <dbReference type="GeneID" id="27338675"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11592"/>
    <dbReference type="HOGENOM" id="CLU_072353_0_0_1"/>
    <dbReference type="OrthoDB" id="4941332at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249188" description="SMODS and SLOG-associating 2TM effector domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37818" checksum="22746B7DFDF2E400" modified="2015-04-29" version="1">MSAPVAVTTTLFIAFAAALGRNFDYESQRWGFRGRILGLFRLVDTNAARQLHWNINTWTDDEVMAWKQSCISNCTAIQVAGAIFASVGLTALQLPNMDSSHWSARALLSCSMILGVLSVVQAASLQQHISVLNRAFDIRLWLSRGKIETDKTHYRRPFHYLPLESSVATLKQFSMPKALLNWAVLLYTVGFGIYLLFAWIYHVESEGGRNDFRNVFMSFVATVGVVYVSVFVVDMFAIADERKRVFEFDLNRTTTFAKPVSQKQLEEWLAALQDMQNTTVGSGELYARLETAVEKLQSKWDAERRLERLQLKRELRRQLTEMREARVGAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVS1</accession>
    <name>A0A0D2AVS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230716.1">
        <property type="nucleotide sequence ID" value="XM_016385772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVS1"/>
    <dbReference type="STRING" id="91928.A0A0D2AVS1"/>
    <dbReference type="GeneID" id="27338547"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11464"/>
    <dbReference type="HOGENOM" id="CLU_616818_0_0_1"/>
    <dbReference type="OrthoDB" id="5326346at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="49423" checksum="C12993EAD700EF30" modified="2015-04-29" version="1">MVMDMAAAGNDLEVIDKDGDLILEVGVEHNASIKMSDCEEYDPEGVGTEENVGREDTPSDRTYVRLLVSSTFVTHASPVFKAMLDGRFAEGQLPPSKQNPPSITLPEDDPDATALFCRILHFGDNDSDKSNSADQLMNLATFSDKYDCGRCLHPWFQALLYRSTFPDTGLFDQDALGPLGINLAHVIVISYLLEDNDLFSHATETYCRETPPSKTRGYLVEAMDDLVPEHIADTVQSWQKVFIDRASRLGLDVLQYIVECVHCRREPRDPIRFGSVDGNGKAIGIAVCSRLAQIMGGLSGVLISSHMFPGCDNQKHGKEDTFDDMMTQWRNVADIDFDQEAISTSCPPDNLCDLCGFVPHISTELEDRIQELEFCLKGGICLPCCKQKGKFEKYVDLLKSGIGNEICWGCLKRKGKVATIRKCYDFVSHAKWRHCVLNAGKEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXJ4</accession>
    <name>A0A0D2AXJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231391.1">
        <property type="nucleotide sequence ID" value="XM_016384789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXJ4"/>
    <dbReference type="STRING" id="91928.A0A0D2AXJ4"/>
    <dbReference type="GeneID" id="27337558"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10475"/>
    <dbReference type="HOGENOM" id="CLU_408272_0_0_1"/>
    <dbReference type="OrthoDB" id="4121301at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="684" mass="75180" checksum="E74829014160234C" modified="2015-04-29" version="1">MCKAIRYRFLKCLELPLHARGCWQGDGSIDKIVYELCDYAKGKVPDKQPYVVGYPPDQKAYNFFRIPHCPVVCEEREVDLLCVQCQKRLFQDGRSERPDPWAEAYDLLSDPQHEFTWHVPYMPWQNPFFREVNWNPVERPAPLDEPPFSPRNGADYVHPEVGVLNPNDTPTRWQSADGRVVVLLDTSEDKEYRMTEWPVEISGKAEELIAWEWKQQCLLMKQQQQQQQQQQQQQQQQPQQPQWRPRDASETSSSDSSSSQQSGRGAIRVGFNACESGAAPADINQSRQHLQIHAHPRAELDPIFDSLCQLLLQPVPAVTSQIPSQTTGVVAPPAPTTATQPSPPRLTRGRLLSSTCTRLPSIPGWEPDSPSKRSRESSVDTDTASRSSKRRRLDTDKPPNSSHDAPQDPQPLPSQSSRSAVDRPKIILRLRNPNAGARKPSQPRPVKIRLIVTNRSRPQTSDAAQGKNTGIFRPGLPRLRVFIPPAPTGTIVQQFPPQGLPASGYVPGTDIRVGPVDNNVRTRPSPDIPSISSISSGESSSSSSSRTVGDGSTPSGKPSVGSGSEAEDEDESTASSSHASASRTTGTSSTASPSHVTSVETPCPKPKPVKILLKLVLKPLGVTRNSTGQQRRSHSSRPAAPRAPMGSPLHVSTGLTTRARARAQRAARGPMTRARLRALQAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYI8</accession>
    <name>A0A0D2AYI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231671.1">
        <property type="nucleotide sequence ID" value="XM_016385069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYI8"/>
    <dbReference type="STRING" id="91928.A0A0D2AYI8"/>
    <dbReference type="GeneID" id="27337838"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10755"/>
    <dbReference type="HOGENOM" id="CLU_263234_0_0_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="629"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="657"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="722"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="752"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="784"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="817"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="852"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1018"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1053"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1189"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1231"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1267" mass="139200" checksum="CB368B27758E9432" modified="2015-04-29" version="1">MVTPDLARLASLGRKNFALLEQVIGGFKSGLLEDAHARNHCAFLNEYERYRVWAVESGLLAPGHGSLDYRLRESGTLTELFELILNGLAQNLEETLELGRSRQGGDQSRERLDAVEPHSDDPDCFEDEEEGELEPQSYIDILLEVIVGLVNRLFKLSTKIRNTSTRLGFSRAKFFESIDKDTGVDLIKAFAHYDDDYVRSVFLQYRLDAPEEIRSQEAQDLSSMRATETLWHQTETCELCQSRGSIPEGSTISGESQSYEDAEEDSPEDIEQLQHQIGAHYLVHRIAQANNKRRQQFGYWKEHYSKLQKHTETVLATIRPRTLAEPDRHLQPAAVDGFERELNSRQTLGISALLAPPTVTTATRLEPSLLNRMDERSVTSVSEYAPSSWAPDRENIGFPPPPKKPLGDKFFECPYCFTICPRQMLSDKAWRAHLIHDLRPFVCTYPDCQIAGQLYDTKSAWVEHENTVHRKQWRCPDHPDPPYSSLQTFEAHIAALHGSDATYLRSDTFLQACQSFSVDNDRPCPICLSSSFRDVQALQSHLSQHLIRMSLFSLPRSTDADDGRSQVGSDIAVGEVLDSRADDDENSSDGGEAWDDIAEAAGAGDTERLTNILLEKQENGLSVEVLNHALCKASAKGHTETVEILLDNGADIEAVGQEETPLMQASIENRIEVVRLLLGRGAHVNEGRSLSTALTCATEYSDIEIILELLSAGADPNKTVDDGSSAVRQAAIAGRLNVLATLMDHGADINAPSLPALPAASSRGHKEVVQLLLERGAHIDAKAIGETALMGASLGGYQEIVKTLLDHGADPNLVDNTGNTALLMVSGTRHEHVEIVKMLIDRGAHVDHTDKRGNTALHAAAARGYANVVRVLIDAGADLERANQVAVTPLQAALKARQHGVVTMLLEAGVKGTQPADPLDELILPQLAGGTMVTSKKSPPSLPRLWRIETLSSTETAPRLTLVHDIAPGSILTCVSFSPDGSYLAVAGQAVTWLVDLEDVSKMYPLPHPGSKHDGLYVRSVCFSADGKSLATASEDYIVRLWDVETREVKHLFGQHSQEVHSVAISPDNNMIASGSSDGEFYISDCITGDVISSSRAKHAVTSVAFSPDSRLLAVGTVNKDVLICRELGTGEWYNLSMMTPSPTETVYDVAFSSSGEQVFCASLDSNIYRWHFKDEGGDDLTDCKSQVLSGHNGYALSVAETRDCRWIVSGSRDKTVRIWSEESGQAMLLLEGHEDTVFSIATCPEKNLIATASGDMTFTVWRYENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYL7</accession>
    <name>A0A0D2AYL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232029.1">
        <property type="nucleotide sequence ID" value="XM_016383406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYL7"/>
    <dbReference type="STRING" id="91928.A0A0D2AYL7"/>
    <dbReference type="GeneID" id="27336169"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09086"/>
    <dbReference type="HOGENOM" id="CLU_041940_0_1_1"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="401" mass="44253" checksum="152C983A1FF4E27A" modified="2015-04-29" version="1">MDRPAVPTYVLRGHDAPIHALHFYCRNTYVASGDGEGWLIIWSLATKRPVAVWKGHEGAIMSIKQWTGKRLVSHGRDHKLRVWQVQDEDLAGLSTNLPGDKTTVARREPWLLHSMSVNALNFCAFSMCNESPGRNSDTAALPQLIASPNGLDSGGIDIFQLPSERRISQIASIQGSPTGMVMAVSIFHDASSRLVVVSGYEDGRVMVHARSGSFADEGGWQRIMLTKAHPSSQPVLSLDVSPSNDYFITSGVDSWIARYSLNIPHTPSETLLETQAEKSVKTKHAGQQGLSIRSDGKIFATAGWDARIRVYSTRTIKELAVLQWHQQGCYATCFADVDLDLDDTTTPTEHSDSDPSIQSKEILAPPTALEIIKRKREEKARKVHWIAAGGKDGKISLWDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZ67</accession>
    <name>A0A0D2AZ67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231981.1">
        <property type="nucleotide sequence ID" value="XM_016383358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZ67"/>
    <dbReference type="GeneID" id="27336120"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09037"/>
    <dbReference type="HOGENOM" id="CLU_025452_0_0_1"/>
    <dbReference type="OrthoDB" id="4140097at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="505" mass="57665" checksum="84CFF3A684ACA2E7" modified="2015-04-29" version="1">MTDQPYKGALQWINLDADNLDPLAHKHKILSHVQQRYRPWRRRARSEALFASIKSTLSTTRIGTRQDEKAQSRTPIRTPLPSKLIAKGNSDPFAAYPVRIGPEENDLMILYRDYMIPSLYSTELGQKHLIDLATQDWKDAVGLLEDKGAAFGALARYGSIAGKFNPRLQYLAYKYHVKSLENLRAKISQGHDLQNSADCMHVSMLFAAETVSGNLSEAATHGRILLKILQKQWREQRHDYKLLIYQLIVDFHLSSMSVKRMIFDDEEWLAEISQQVSDAAALYAPVYPKKDWDPCIPDEWLRTSFEAEQQRFNFIASPPKITDATSHLELVFLSQMLQAVLFHSRMIHHYLKVAEQLRNSRLSDAKAEQLTTQQYLALAAAQLRRHVGMTPKIFGVYIYDSSALIMALKHALQASDAVSRRMSSTKYRNAKLWALYVGALAETATSSTNECSSEHWFNKMLADTAIAMNIRSWDKLQAVLEGFLYYDRPFYITRPACFEQGHLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZT8</accession>
    <name>A0A0D2AZT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232464.1">
        <property type="nucleotide sequence ID" value="XM_016383841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZT8"/>
    <dbReference type="STRING" id="91928.A0A0D2AZT8"/>
    <dbReference type="GeneID" id="27336607"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09524"/>
    <dbReference type="HOGENOM" id="CLU_048616_0_0_1"/>
    <dbReference type="OrthoDB" id="4367324at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="269" mass="30592" checksum="72604DBBB095970E" modified="2015-04-29" version="1">MADNHNGRATIRDLLTRPKTATIDCIVTSAAMNTAYANWPEVRTITIWEEFNLENIDSELGQILDESLTGTPLHPTGFPLPDGFQVDSQRNLYPLFERNERVLQETIPHARQRLNLHLDMQYRSDYTTQTHANAKFPFNNGPPFFQHAIWLQHQATLNILAGLGKTSKHWSGSEVREGLANGNGLSRGLQAPLRQLANICLLGNIRHGYLQTDKELVVCEFTFSLDRKFDVRFMPVMWSVTQGLTTDLALFTLCLLAMYVIFQRTLHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0A8</accession>
    <name>A0A0D2B0A8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_09415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232356.1">
        <property type="nucleotide sequence ID" value="XM_016383733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0A8"/>
    <dbReference type="GeneID" id="27336498"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09415"/>
    <dbReference type="HOGENOM" id="CLU_028200_6_1_1"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="355" mass="39652" checksum="D095C65DD8F9C57A" modified="2015-04-29" version="1">MAIALLLVGVRIINLSRDFSMLWGWDDLVVAVATQGITVDVLLARSYGYGRDTWRLPFDHTKTVEMLFYIGGVLYAVGVAATKVAFLLFYIRLFPSPALRRVALPLLAITLIHGLIFTFLFIFQCSPVSYAWTQWDGTGKGKCLNFDVGAVLHAITNIILDFLIFALPISQLWKLNLSQKKKIQVLFMFGVGFFVTLVSILRLWSLISLNNTWNPTWDFVPLGYFSDLEFNVGIACICMPSVRVVLRHYFPGCGLSTTNRDRTASDHDVQARRVNLTDTSNGRKLKSFVSSRGAVRDDSSDQVELFQYNPTVATSEVNDSHDHGTRSGASKPLPQPKRAHIADAVKHTAWSSEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0C3</accession>
    <name>A0A0D2B0C3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232381.1">
        <property type="nucleotide sequence ID" value="XM_016383758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0C3"/>
    <dbReference type="GeneID" id="27336523"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09440"/>
    <dbReference type="HOGENOM" id="CLU_148793_0_0_1"/>
    <dbReference type="OrthoDB" id="4153969at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="148" mass="15436" checksum="9B987B2442708A50" modified="2015-04-29" version="1">MSGAFTMPHALTGGAGYKANATYDDFLRRHSGFYRRHSAASNAMESDRRASQASLDANAAAAAQAVQNVADDKANGNRRASVTVAGGGSATANARKGSVAVASDVTRKDSIFGLEPTGGTRMSEERRPSTSLASDLYHKMKGDGKNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1Q2</accession>
    <name>A0A0D2B1Q2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_09817</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232756.1">
        <property type="nucleotide sequence ID" value="XM_016384133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1Q2"/>
    <dbReference type="STRING" id="91928.A0A0D2B1Q2"/>
    <dbReference type="GeneID" id="27336900"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09817"/>
    <dbReference type="HOGENOM" id="CLU_015495_5_0_1"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="285"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="565"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW12540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="632" mass="68758" checksum="59BCE5A4D9E16E34" modified="2015-04-29" version="1">MTLLILTETAAGYALLKAKDKKLLKRDDLASDLNGVESVTSELKLKEFQKFDSAAAALEEAAALVEGKVTPKLSSLLDSLKDEKKISLAVADPKLGNAIGKLPGLDIKAVADSTTADLYRAIREHLPSLIPGLMPEDVKTMSLGLSHSLARHKLKFSPDKIDVMIVQAIGLLDDLDKELNTYAMRVKEWYGWHFPEMAKILNDNLAYAKVVLKMGMRTNWEKADLAEILPEEIEAAVKAAADRSMGTEITEEDLENIQSLAEQVVQFTEYRTQLASYLTARMTAIAPNLTTLVGELVGARLIAHAGSLLNLSKSPASTLQILGAEKALFRALKTKHDTPKYGLIYHASLIGQASGKNKGKMARVLAAKAALGLRVDALQDWGEDEANIPEDEKAQLGIEARANLERKLAAMEGKPIKSRGVAIGPNGVPGTSQPQKWEIKEARKYNPDADGLAGDEAPAKQSKKEKKLIQELTSDTVMGDGDLSDESESQPDEPIDAAEASAINGVDGKKSAKKAEKERRHAEKAARKAAKKEKKEGKGESDETKIETLAALCGLSVERYKRKLERGEIEFQEDGKPVAISKKDIKKAKKAAEKQSAAAANGEVDGSKKRKRSEEESEPTKSDKKKKRKDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1V4</accession>
    <name>A0A0D2B1V4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232796.1">
        <property type="nucleotide sequence ID" value="XM_016384173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1V4"/>
    <dbReference type="STRING" id="91928.A0A0D2B1V4"/>
    <dbReference type="GeneID" id="27336941"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09858"/>
    <dbReference type="HOGENOM" id="CLU_1026856_0_0_1"/>
    <dbReference type="OrthoDB" id="5281164at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29515" checksum="AE3E771F4B71D8DA" modified="2015-04-29" version="1">MTESDLKQQDTFEQTSSMENTTMTSAEGGNADTDAAAELDKQSQSQAQPTSAECSRPEAPSESEPVPPTSRGMVIFGPSFPDLPAPPRPASLFSLPADVVCSIAGHLEYPDVVSLQQSDDGLAEALATHSNSSDRSSWIESRVHLGLPVPTGQPDFKTDAAFLSNRKLRGFVAARADHGECLSQDDRSVARSLARMRHGNRKGTNLCFITGGPCVAVLERRHRLHVLNRRRQRGAGPTVVDKVWWGVRLCVAVPLCLVLLWVAYQIHMLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B225</accession>
    <name>A0A0D2B225_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232871.1">
        <property type="nucleotide sequence ID" value="XM_016384248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B225"/>
    <dbReference type="STRING" id="91928.A0A0D2B225"/>
    <dbReference type="GeneID" id="27337016"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09933"/>
    <dbReference type="HOGENOM" id="CLU_022501_3_0_1"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF11">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="519" mass="57376" checksum="54059EEB30E97916" modified="2015-04-29" version="1">MGSMIWNRMVLRLPPILRPRWTWRYLLCFSVATVAIYNFLLARPLLSSNLPPYTGPYQVGTLDLEAPCEPRRINDATLKDGQHPAFEVETVLFTLYYPSVDGASSSKPHHLWVPRPLGIVGAGYARFARISNFLTNSVMTFALWALAGSIKIPAHVDVPLHHGPAVLQTPAGTSSVEVDEGFPVLVFSHGMASSRTQYTQYCGELASRGHVVAAIEHRDGSGPGTLIMSPSGRHRTLLHFSHRDLHHDAGLDADTFKQAQLDFRQAEVEETVRVLKQINAGHGDRIFSQNSRGEGQHLKHWRGRLAMNNTTIGGHSFGATLALQTLKGGPTIHLPFQSAVVLDPGKQSGPLNHDVNVSTLVIHSNSWSSRYSIFYGRPHFETVKDVVLGVLERGKAAWFMTSLGTSHPSVTDAPLIEPLLLNWATGSSIDAHEGVRQYVKVSEMFLQYQTSGVKKGILSECVTHPEYNLPEEGRFEKGKPSNEDMWKYWQIHAAPCGPEAFENESEGTLYPETNPLLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2L1</accession>
    <name>A0A0D2B2L1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233374.1">
        <property type="nucleotide sequence ID" value="XM_016382671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2L1"/>
    <dbReference type="STRING" id="91928.A0A0D2B2L1"/>
    <dbReference type="GeneID" id="27335428"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08345"/>
    <dbReference type="HOGENOM" id="CLU_785316_0_0_1"/>
    <dbReference type="OrthoDB" id="5367275at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="352" mass="38942" checksum="704FB821DE2591A8" modified="2015-04-29" version="1">MVLLTSSAVSVALSSGVVCLFTFLLFMCGYVLQQQTVRSIQEALKRPPEPKPMPTLPPSFQNSDNESITGALEQPVNSDSVRLGYSGAEEVEEAAENVVAVQVPVEAQAKDQNRLQMPQDSSTTSSKSQQAPEQPALDHLAYMFILLEPEDLCSTLLFAKEHRASSRLVQEPSIVLIYPATWEIESSPAYKSALSFMREVQEIYGLIYHPVQINNAWGTKAQLLGELQWHRWGYDQALYLQSPGMVLDNKALDAALSSPVSRKTWAAVDTSTGNNPDILLVTPKGLQSPRREMRNLVVPARPGQSFQPSDAAYAWFDHSNSGQTSHDNVWYDELIRKFERGERSVCAGSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B328</accession>
    <name>A0A0D2B328_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233211.1">
        <property type="nucleotide sequence ID" value="XM_016382508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B328"/>
    <dbReference type="STRING" id="91928.A0A0D2B328"/>
    <dbReference type="ESTHER" id="9euro-a0a0d2b328">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="27335265"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08182"/>
    <dbReference type="HOGENOM" id="CLU_006586_17_1_1"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="12"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="570" mass="63174" checksum="A7A921129981C66B" modified="2015-04-29" version="1">MRPAEYTSRPYVLKTARGSLRGTEYCTPSGEPVVYRFARVPYALPPVGARRWRRPQPVPSDFSFDDHAGQPGDYTRFGPVCPQPQYPHGQALVDNAAAAAPVDNVQDEDCLYLNIWVPAGRAPTDAGGWPVQFHIHGGWLQVGNAMQDHTHDPFDLVKDVAPRVIVSPTYRLNLFGFLGGAELASLGEEEAPSNFGLWDQRCALEWTARHVGLFGGDPDNITVGGLSAGANSTFFQLNYDSALPASQRLIKRVYLWSNAVAIQPNPTPSPALTSQFDELCSLFDVPRSATAAEKVARLRAVPFGDLVAANTRMKMHTFRSSTDGAFILPTFLSSLHNGALTTRLARNGTSVLLGEVRDEKELYKFVNPPSDYAGLLLQLANYYPKPVLEALLNVYDLPPRDSTDAAAWAEVFSQMVADSQVHASIRGLTHLLLNPPPGNPNVRALPQSSVHRYRIAWRAESVDNWLKPEVGICHGGDMPLWWATAWRQDFQEKDKLATKKFLAPFTQFLRGEHVSWGCTGEDRVRLLDTDGEVKENVKDDLWERGMQVFNTVWEAQKGPVAKDTSLESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3Y6</accession>
    <name>A0A0D2B3Y6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233854.1">
        <property type="nucleotide sequence ID" value="XM_016383151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3Y6"/>
    <dbReference type="STRING" id="91928.A0A0D2B3Y6"/>
    <dbReference type="GeneID" id="27335912"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08829"/>
    <dbReference type="HOGENOM" id="CLU_021588_0_0_1"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF4">
        <property type="entry name" value="BLR3030 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="481" mass="52007" checksum="A185E67271DFC8A3" modified="2015-04-29" version="1">MTLDRSTFTALDTVRHLWRHLGLPAHALTSLSLTGEGHGLPSSFQVGHLAQASIGLSGLTAALIQAQRKGCPVPRVTVPLQHAVIEFRSERFCLLDKKSSSAWGPIGGLHACSDGHVRVHDNFPHHRDGIVRLLGCEQPTTRSQVGDAISSWRAVDLETAAADNGLVVAALRSYKQWDVTPQAQAIADLPISIAKVGEAAPGIPRHIGPGKDKCLRGVRVVDMTRVVAGPVAGKTLAAHGAEVLWVTGPHLPDLPELDRDLARGKRTVQLDIRKPEDLETLMHLLESADVFLQSYRPGSLSALGLTEEAIVRRRKGRHPIVMANLSCYGTAGPWKHRRGFDSIVQTCSGMNVSEAEHYGKGDAARPLPCQALDHASGYFLAAGIMAGLYRAWTDGGSYRVDVSLAGTMKYLRSLGQLPGDSGFEATEYDYHKPEDVPAEYFETRSSGFGELQAIKHSVSVDGAQVGWDIMPQPLGSHEPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B464</accession>
    <name>A0A0D2B464_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08944</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233969.1">
        <property type="nucleotide sequence ID" value="XM_016383266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B464"/>
    <dbReference type="STRING" id="91928.A0A0D2B464"/>
    <dbReference type="GeneID" id="27336027"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08944"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="18"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW13753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="354" mass="38139" checksum="CEBB94D70345F725" modified="2015-04-29" version="1">MPGETMKAFRLVEYGKPGQYCEVPVPSPKEGEVLIRMKAAGLCRSDLDMVDSLPGTDPYASAVDAPYTLGHENAGVIEVLGEGVTDLKVGEGVAVRHMPHCSHCEFCIRGVEQHCETYKRGAIEITRGSGFDGGLAEFMLCPRDQLVSIGNEDPVKYAPLTDAGVTAYHAVGTIKDRLRPGSSALVIGCGGLGSYAIQFLLLLMGVKVYAVDTNESRIQIARDLGAKRVFKAGPNATKEILDETGGKGIDGILDFVGNTATLRMAMELSRPQGRVVLVGMDMGSVEVGWNKIATSCEFAISLGSTRRDLEEVCYLASEGKLKIDVDRFPFDKIPEAYQALRDGRLIGRAVITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4W4</accession>
    <name>A0A0D2B4W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_08936</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233961.1">
        <property type="nucleotide sequence ID" value="XM_016383258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4W4"/>
    <dbReference type="STRING" id="91928.A0A0D2B4W4"/>
    <dbReference type="GeneID" id="27336019"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08936"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_1_1"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="11">
        <location>
            <begin position="103"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW13745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="335" mass="35314" checksum="AF726BB3865B2987" modified="2015-04-29" version="1">MSKTAKLPSSPVNTLSSHTGPINAIAFSSQTGTYILTGSSDRQIHLSRTEPADPDKPSAGPIQKYVAHGYPILDITVSQDNQTFASVGGDRSVFLWDVASGAEGTTRRFGSNTNQGHSSRINCVAFAGDSDSVIASGSDDTSVRLWDVKSRDAKPLMILEEAKDGISSIVVPGNGYELVAGSVDGRVRSYDIRMGRVTADVMPGPVTSLDISRDAKTILVGCLDGRIRMMDRADGTCLRAFPAPEDDAEGYKNTSLRLKSCLAINESLVLSGSEGDGNVRGWDVLSGRSVGTVRVSPSGKVVSVVKWREGSQAQGRQGVWAGGSADGLVKVYSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7H6</accession>
    <name>A0A0D2B7H6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_07658</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235089.1">
        <property type="nucleotide sequence ID" value="XM_016381987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7H6"/>
    <dbReference type="STRING" id="91928.A0A0D2B7H6"/>
    <dbReference type="GeneID" id="27334741"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07658"/>
    <dbReference type="HOGENOM" id="CLU_001042_5_0_1"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000424">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SMC"/>
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    </dbReference>
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        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="11">
        <location>
            <begin position="519"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1044"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="186"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="420"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="690"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="844"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="975"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW14873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1206" mass="137636" checksum="AEA973A4BF270365" modified="2015-04-29" version="1">MHIKQITIQGFKSYKNQTVVNPFSPKLNVIVGRNGSGKSNFFAAIRFVLSDAYSQMGREERQALIHEGTGSAVMSAYVEIVFDNSDGRFPTGNDELILRRTIGLKKDEYSLDRKNATKQDVMQLLENAGFSRANPYYIVPQGRITRLTNMKDSERLDVLKSVAGTQQFVAKKEESQKIMSETNNKLVAIDQTFDQINERLAELEEEQAELRDFQEQDREKRALEYTLFTREQDEINKALAELEDRRAGGIDDADENRERYAEGEDELARITQQIQNLNQQIHAARLEKRQYDEEKREKAKARAQVELEERNLTHGQAAAHRAKQAHDKELQQVQAQIQQVEKELNTIIPQFEAEMAKEQSVKSRLDEATATQEHLYAKQGRNARFKTKKARDDWLQAQISEAFEALSRFKATRMQTLEGIEEDKKAIASLEKEIESLQQQVGGQDDSLDQEIQRAQQRRENLMDERKLLWRREAQLDSEYGAAQDELRKAERNLSHMMDGNTSRGLEAVRRIKQQHNLEGCYGPLAELIDVAQHHTAVEVTAGNSLFHYVVDNDDTATKVMEILNRERAGRITFMPLNRLKPKTANFPNAPDARPLMSLLQYDKKYEKAVQQVFGKAIIAQNLSIAAQYARTHGLTAVTPEGDRSDKKGALTGGYHDVRTSRLKATKAVMAAREKFEAVKAESAENKKKIERMDQTVTKAMSEVQKLEQRKNQSQGNQRLLKQEIRNKMDMLQRKKDDLEAKQKQEIAISANVKRLSDSQNAYQAELNSDFKKALTQAEEAQLENLTATIQNLRREYNKLSASRAETEARKANLEAQLNSSLRPQLVALETDEFETEGDVSAHLRAKRAELARLSKELESVQESLDELEDQIETASTQVAQLEAQAAETRRQQEELAKAIERHQRRLEKSVQKKAALQASKQETIDNIRELGAIPEDLRKKYRNTDSNTIVKRLQKAKEALKKYSSVNKHAFEHYRKSAKQREELEGRRKDLEAAKASIQNLIEILDQRKDEAIERTFKQVSKAFAEVFQKLVPAGRGRLIIQRKTDKRQAEDEESEDEQPVNKRGVENYTGVGISVSFNSKHDDQQRIQQLSGGQKSLCSLALIFAIQATDPAPFYIFDEIDANLDAQYRTAVADHLLYLANRADEEPTNGDERPTGGQFICTTFRPEMLRVADKCFGVRFGNNVSSIREESMEDALDFVESQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B852</accession>
    <name>A0A0D2B852_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_07845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235274.1">
        <property type="nucleotide sequence ID" value="XM_016382172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B852"/>
    <dbReference type="STRING" id="91928.A0A0D2B852"/>
    <dbReference type="GeneID" id="27334928"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07845"/>
    <dbReference type="HOGENOM" id="CLU_093893_0_0_1"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="5">
        <location>
            <begin position="15"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="70"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="222"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="291" mass="31468" checksum="1194845D7F96D38D" modified="2015-04-29" version="1">MPSNHPLHEKVTVALQNKHHLTVDPRWLDEFLATRGSNPPPLPAVVSTAQFRILASDITTSLSPSPQDALPSDVADVNVKGRRLSGTVIVQVLDVLDVGSSKWSQVEAIERVERGEEVRGREVIRTVDIMDDEDGSGRDPSASAVTRPPTATAPASRAIVSMPGRNISLGPHKLVVQDARGTKAVAFELDKIPKIGISISALASPPGPHGDASSRPSSQDDIGMFIGCKLVLKPGTIVRRGMIMLQPQTCFMLGGKVEAWDKKWKEVRKQKLNDIIQEEYDAAGNGTRTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAK2</accession>
    <name>A0A0D2BAK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235821.1">
        <property type="nucleotide sequence ID" value="XM_016379994.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BAK2"/>
    <dbReference type="GeneID" id="27332736"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05653"/>
    <dbReference type="HOGENOM" id="CLU_003600_0_0_1"/>
    <dbReference type="OrthoDB" id="4135107at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16655">
        <property type="entry name" value="RING-Ubox_WDSUB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052085">
        <property type="entry name" value="WD-SAM-U-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573:SF1">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="U-box" evidence="5">
        <location>
            <begin position="774"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1047"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1292" mass="143687" checksum="DAB3A1C48FC19008" modified="2015-04-29" version="1">MAPYRVVLILPEGDRLDLELQLDGEHPAGILARAALERIPQDRTLPSTVNLRDLRLTVGSSDGLMIDPADTLDDVLPPSEVLFIDATKLSSVHSLFDSNNESLRIRILTPNTAPNYHDDFPGAFLKEGHQYKLSTTLEEIESDVRQHIGMPDRPSKGENDNDSKEDNPFGSLSVTRLDLHTFEGPINTQNSSLTLKSSKLDKLASQGILTLFAVERRCTDECERTEGHDSMFSAGPHWELPPGGSTERAMATTLASLRLFTHIIASDDFDDFDHHEVLRTVHNMTRFAPAVRAVHILMDGKTLRCNESAALVQSLAAVAENVMPFHPELPNEGRILECARLLLGLVLTIAGHQAEIREDFEDSTGIQTTLPYLTAYRTVDLRDAKTQEPLTDPVSTNLGIVNRSIFDVLSSSGDHVESPACYLLDGSVEDDERIRFALLYGGVSLEASYYQAEDLLLALRDDDERTIGTPPHLHPHHLTGDNGILTLECERIGFVVVHPDQLSLAELPCLTLDGHGRMAVCTRRTATVPLSQRNVIFHPLTGIEENVDIHNVVQSLEPILLGMRRESTWMFDCPTDAFTRRDTTPAELLMFCVDCSYSMNNPPRFTATDDGTATERSDGDKIHLLSHREDYTTVDLDYMKEFLCKHEAYDDILHIIHHSPEHQSRTVAREIIDFIRTHTDRHLTSFSESLRKTSDSASTTDPASVSLIQVKMNILHKTFEGLNIHQDALIDSLLFSAKDPSFEPSDFRWSIGEGVPRNSNGKSQNDMDMDDIFTVPEDFRCPISSAVFAEPVRTTDGFVYDRKAIERWFTIRGSAPMTGLPLDDRTLTPDEDLQKQIRDWLKSEDIGRGPQNSPEISQIDPCNTKNIVDFIGPNVQFTREIPHTARLLDVYEFAFRGMRAVHSNFSLFINGTCLPCSEENAKSFISGRPIVTIGPCHVPGTAAFRDDGDEMCLIKLHHGDNPTREAFSYWTPLHSQLTFVSVLFRAWRYQVQFKQPFKPNVDRAVWTEIQDVGDDFLQGTRHSSWEPLSPLLLNLPVPHIQTDEDSNNNNNDVSTDDLPLPEGYKPDRVIGLYLFDNDDSRAQERSSSSSSSSSSSLALAKQVFGSFVDRLVANDYPTHVGLVTFGSNARIDERLGAFVDEFRGAADNLAARGDTALWDALALAADHLVEEGRRFQGGSGDRIKMRVVVLSDGRDTSSRLRLEDVVLRLGRFGVVLDCVCLGPGANNLELRALSYLTGGQKCVPASAEEALAICEETSLLSLNERAPLARPPVLDPRTPSLMATMAALARGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE34</accession>
    <name>A0A0D2BE34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_04045</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237071.1">
        <property type="nucleotide sequence ID" value="XM_016378394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE34"/>
    <dbReference type="STRING" id="91928.A0A0D2BE34"/>
    <dbReference type="GeneID" id="27331128"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04045"/>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF5">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="128"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="400"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW16855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="518" mass="55327" checksum="CDC1AFF091C8A706" modified="2015-04-29" version="1">MSTPLQCGGTIWNMENRGLKRPHPKPSSDGNVSDSSNEQCPYPRAIFFAADTPAVAPFNIQIFAFLPGEPSLVSFHSFHDETVHLRQPSSHPTFPFSILATVGLPQTSLTMANARGLKQILSKNPSDVVILSSLRTPVTRAYKGGFRDAFDHELLSHVLKATLAANPNLDPARIEEVAVGVVLAELGGSKAARMAQQHAGYSEKTPLYTVNRACSSGLQAVTSIAHSITVGQIDVGVGAGMESMTKNYGSKAIPTMLWDELRNSPHDNTKDCIMPMGLTSENVARRYGVNREDQDAFAAASHQKASKAQKTGLFDAEIVPVKVKQVDPENPDVSKEVVVDKDDGIRHDISAEKMAKLKPAFAQDGTSTAGNSSQISDGAAATLLMRRSTANELGLTKSIIGKWAGTQVAGCRPDEMGIGPAIAIPKLLDHTGLKTEDVNIWELNEAFASQALYCIRKLGLDIEKVNPRGGAIALGHPLGMTGTRQLATLLPQLNEGEVGVVSMCIGTGMGMAGLFVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFJ2</accession>
    <name>A0A0D2BFJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237989.1">
        <property type="nucleotide sequence ID" value="XM_016379312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFJ2"/>
    <dbReference type="STRING" id="91928.A0A0D2BFJ2"/>
    <dbReference type="GeneID" id="27332051"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04968"/>
    <dbReference type="HOGENOM" id="CLU_072377_0_0_1"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="130"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="319" mass="35935" checksum="F80276FF557A8466" modified="2015-04-29" version="1">MADDRIIYMVSTRQFSTALSSSPVVVAEFFDKNSISERIAPTYERIARRHSQPKKITFARIQVDHQSDIANSYGVTTTPTYMIFKNARRVGTLVDPRAEELEEFLKDVTDEFRTMETTEAGHSASDSPWYGAELPRGYVDVTDQVDFLGLELLNWDSSHGNARKLISKDKPSATPEAKADFVQSDTDEQLMLYIPFQSTLKIHSVHLTSLPDNTDDDESPSRPKLIKFYTNKPHILGFDEADGAPPTQEVTLTEKDWNPTTGTAKIDLRIVKFQNVSSVVIFIVESEGDNEKVRLDRIRIVGETGEKRDGKIEKVASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFM6</accession>
    <name>A0A0D2BFM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230380.1">
        <property type="nucleotide sequence ID" value="XM_016385436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFM6"/>
    <dbReference type="STRING" id="91928.A0A0D2BFM6"/>
    <dbReference type="GeneID" id="27338208"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11125"/>
    <dbReference type="HOGENOM" id="CLU_036742_0_1_1"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="443" mass="49659" checksum="D74DE5AA9D00809B" modified="2015-04-29" version="1">MPPRRSRASGATPSSRTAHKRQLSETPVSATPVSRTSKRLKESASKIKSTPTKSKYFETADSDSDDTAESPDEAEDSGYEDQNTSAAEDITESEPESRDDSDSEEDEKKQRSKRKTDRKSHTGVGTPGPVVLEKGTELWRPGVSTGLGPGKQVFIEKPKPRGDGGIKYMPGRIHPNTMAFLKDLKNNNDREWLKMHDPDYRQSWKDWESFVETLTERISEIDETIPELPPKDLVFRIYRDIRFSSDPTPYKPHFSAAWSRTGRKGPYACYYVQIQPGGKSIVGSGLWHPEAQPLALLRADINGKPHRLKRILMDPQMRKQILAGAPNDEKKVLKAFASQNSENALKTKPKGYEADHPNIELLRLRNFTLGKSIPDEKVTGEHGLQTILDLIGVLQPFKRPIREPSQLNQWFDSADKSGPGGLPMAFSDVQIVPPLPSHLQDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGT2</accession>
    <name>A0A0D2BGT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230730.1">
        <property type="nucleotide sequence ID" value="XM_016385786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGT2"/>
    <dbReference type="STRING" id="91928.A0A0D2BGT2"/>
    <dbReference type="GeneID" id="27338561"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11478"/>
    <dbReference type="HOGENOM" id="CLU_020336_50_3_1"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="65"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="315" mass="35103" checksum="3890C46E7B123F84" modified="2015-04-29" version="1">MTLHGTRYFYDNASNREGRSRKRSRERPSLSHAMNPHSQFITHPTGETTHFIADCHADPWKPCETVLLQGGFGRHSAFFYHWIPALSRHYNVIRRDLRGHGLSSAPSIRDKPESYTLDTILAEIVDTLDQLKVDKVHFFGESTSGILGEIFAARYPDRLLSLTICSSPTHLPQAALDLFAMGQPSWPEACRTLGSRGWGQALSERPGTMASKDRGYRKWWLDQVSISSGEGLGSYAEFLCTIDSRPVLGSIKVPMLILAPTNSAATTVAAQKEIQRQIGSHCRLVEVDGPGHEIYMDAADDCISAFLDFIKSVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BH23</accession>
    <name>A0A0D2BH23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238136.1">
        <property type="nucleotide sequence ID" value="XM_016379459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BH23"/>
    <dbReference type="GeneID" id="27332198"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05115"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="27741" checksum="90C3402DF26765DD" modified="2015-04-29" version="1">MADNKKIILITGANSGIGLDTAHALVSASANNHVIMACRDKSKGDKALESLKSSPSSSSSSGAALLGTLSLLELDITMDDSISAAVATVTADFGRLDVLINNAGIMNIRPSSRRADLLSTYNTNAASPLIFTEQMLPLLKKSADPRVINVSSGLGSVTDKYDPESQYYKVPGEPYRMSKAAMNMATACMYASYKDWGCKVWSFDPGFVVTNLSGVENRGRRVSMGAESSETSAKGLREIVDGLRDGEVGIFIGREGSTLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHK7</accession>
    <name>A0A0D2BHK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238306.1">
        <property type="nucleotide sequence ID" value="XM_016376736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHK7"/>
    <dbReference type="STRING" id="91928.A0A0D2BHK7"/>
    <dbReference type="GeneID" id="27329460"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02377"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_2_1"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="388" mass="42810" checksum="ACA4CCA9C6B398DD" modified="2015-04-29" version="1">MTAPALHLPKSPLGRHRLLSPSAGVHVSPLCLGGMNFGTAWTSIMGECSKENAFALLDYFYEMGGNFIDTANNYQGEQSETWIGEWMAQYPFRRDEMVIATKYTSAYKIVSEPQLQQSNFGSNNAKSLALSVEASLEKLQTSYLDVLYVHYWDFTTGVEEVMQSLNHLVAAGKVLYLGVSDTPAWVVVKANAYARRHGLRPFSVYQGRWSAAERDFERDIIPMCRDEGMGLAPWGSLGGGYFKPSVSQTPRSNKEDDEEGKGRNLPSTLTGKESQVGLVLEKVANARTPPVPLTSVALAYVMHKAPYVTPIIGGRKLDHLKSNIEALSIRLTDAEIDAIESAYPFDVGFPMNFVAANPKGPRGPEDIVFTRRMNHLDFVKGPQPILPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIQ9</accession>
    <name>A0A0D2BIQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239034.1">
        <property type="nucleotide sequence ID" value="XM_016377464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIQ9"/>
    <dbReference type="STRING" id="91928.A0A0D2BIQ9"/>
    <dbReference type="GeneID" id="27330190"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03107"/>
    <dbReference type="HOGENOM" id="CLU_3068666_0_0_1"/>
    <dbReference type="OrthoDB" id="10490382at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="53" mass="5967" checksum="2F880BCECB5E0B33" modified="2015-04-29" version="1">MGDASTAAFDVPKECWAAVVKDEGPNFYVEVEKVPVPEIGKQMRNRLRHGQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIX4</accession>
    <name>A0A0D2BIX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239094.1">
        <property type="nucleotide sequence ID" value="XM_016377524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIX4"/>
    <dbReference type="STRING" id="91928.A0A0D2BIX4"/>
    <dbReference type="GeneID" id="27330250"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03167"/>
    <dbReference type="HOGENOM" id="CLU_007073_0_1_1"/>
    <dbReference type="OrthoDB" id="2354469at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="831"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="888"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="913"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="984" mass="107855" checksum="2D66BA5811862D84" modified="2015-04-29" version="1">MSLSNTPTSELPTRQTSSASLLPPPRQIRFVSTDGQPHAKRRRINAACLTCRRRKTRCSGERPLCKTCTENGHACSGYIDRGGQGDGDKTDHDGEEETLTSNTAIQKLSEDVETTVYPRSSMGAPDAHPPQSSAVMARVQADGGEIKSPGSSQTGNSISSSRNRVPYFRYFGPTAIVPGFKQMVVQVKDHRQGTQTNSVDSPSAGQRLDSTPVLIGESAPVDIPFYDATDPEPNAPLITHLCETFFTYLGCNFPFLQRERFLKDLEDKKVDAILVDAVCAVAARFSSDTVLCHSNDPSIPRDGENKVRRPFRGLPFGQRAIAAVIDTFSCPTMAVTQACLLLAYEEFGLDHDSGLWMYLGTAIRMAQDLGIQKLDGLQLEGRIGPTPSTAKHGQEGKAEEQRRFEQQQELLRDFAQHDPVQMQERKANEQERIDTFWAIFFLDRAISSGVGRPVSWRDKDIEISFPYRPDGTMIDGYPDPFPPMIKIVHMYGRVADVLNSIKDVSQVTPAVLKRLASMEKDLTGIYQRLSPKLHFNATNFQHYVKSGHGTNFVLLHFWFHTLIVLVHQPTLLHSFEGRIQQLFPDSRELSMSSAKTIADIIAFAELIDVRSFAGNPFTSQPMYVAACAFLAEAAAHTSQPPSRTGSPPSSHLSHVQQEVNSQKAISEQKAASARHTLLATAANQNYQRCYKGLKTLDSYWAGSRYILTALDGKAKGLMSPLLFTAEDVDGDMPSTEIAFTTPGWRRTNSLSSSLGAYRTALRKHIALSPTMDFGQVIGWSLTGTANSPAPSFSFLYPNTGGENGQGPVHANSVSAMPGLVARNQQFLHQQNAANGRQSSYDIQTSLNGHPTYPKQEQSASAARNGTTSLPYDPVSTTEADLLLGLQGPYSREASNGTVPGPQAPNALGPQGPPVSSTTPEQQQQSFTAYNQDFNNMFVTSQDVDMDGDALDFDFSSSDMIPWLEYLPQDVLNYFGDPPHGGSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ82</accession>
    <name>A0A0D2BJ82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PV08_03247</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239174.1">
        <property type="nucleotide sequence ID" value="XM_016377604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ82"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ82"/>
    <dbReference type="GeneID" id="27330330"/>
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    <sequence length="386" mass="44778" checksum="DA6B6299BBD5AAB0" modified="2015-04-29" version="1">MPQAEVEAHNTKDSCWVTIGERIFDVTDFVEDHPGGGELILEYAGKDVKQIMEDEVSHFHTDTAYEILEESLIGFLPTEPVLKAATASPHPDEVVPLPATANGNAELKKQGVQTEGLPTREVFETTGMSCAEDLSKDTDLDKDWKQHKFLDLNRPLFPQMLFSKFSKEFYLEQIHRPRHYRGGDSAPLFGNFLEPLSKTAWYVVPTLWLPPVFYGSYLGLTHLPLSQGPAYWALGLFLWTLVEYLLHRFLFHIDYYLPNHPVFLTLHFLLHGIHHYLPMDKYRLVMPPTLFLILATPFYKLAHAVFWYNWYVAITVFSGGIFGYVCYDCTHYWLHHHQLPAYVRDLKKYHLAHHYQNFELGFGVTSKFWDYVWGTQLEYSKPIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D2BJR7_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
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        <name type="scientific">Exophiala spinifera</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
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        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 89968</strain>
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        </source>
    </evidence>
    <sequence length="917" mass="101556" checksum="73D8007269D30335" modified="2015-04-29" version="1">MATKLRAANAAHTAGIFADMSLDGPEIGTLVAVVDRAKNLPNRKTMGKQDPYCAMRLGKEAKKTDTDKRGGQTPRWDQELRFNVHDSPDYYKLKCSIFNDDKKTDLIGEAWINLEGVIVPGGGKNDLWHQLNFKGKYAGDIRIELTYYDTRPKPEVSPERKKQREKTHSLVTDIASTASGSRQLGPREIKRRPLPPGPGGYSSPTSAGITPERLPVDEPLGSWNSQNYTNSNPPPRPPKQPMPETPDDVGFGLPSHYSPDPYAPPQPDTYETPPPPVHHSQDQQRSSNIPYNDDRRQLRLQESPDYYSTEDYTTATLPSTAQLQPYVTDELPQVEAGQVPSPQSPYSQSAQSPYYSPPSNRTTPQATPPWPAQNQRRQSRGSASPTKHAVYRDSPLRQSISQHDMTRSENRHFDPQFDEEEPPPPPPAHRGHISRSSMTTTAYPPPPAGQASPRTPTKYESVDERSPLQRLEQQYDTYGSPSGPDSTRQQPADLGYGKGPEENYNHPQARTQQRTPERYEAYSLPPNVRRQPSNDSTAHRRPISSGSNLPPFEDYQGQSSVDQRYGGMPQDSFRRSTGYDPPRRAQTFDDYGHFDDRHRASEPPISRPRAVSPNPPRNIPRKSITPTPATPEDRRQISGIPYGPDAYDVLNPGTSPTVGDDTYGSSQEAARQREVDKLRDQGPIIGNDGRVIDPSDHLPADTWAPEPERKNRKPEHVIRIRTREEARMQQNTGSSPASMRPHSIGTSPLQSSPGVPASSPYTASPTSSALMEPAPRAEPGSSRNRLKKSMPTRPLPAQPYPHAQTSPAVMPASPDARPSSSGQRHSANSSPIRPLQRQPLSEYQSPAMYDYGSRGGSNSHDYPPTPTKAPHHRPSNSINYGGYGDDNSLALELSTIDIGPSRTGRTSLRPVHGYSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJW9</accession>
    <name>A0A0D2BJW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239096.1">
        <property type="nucleotide sequence ID" value="XM_016377526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJW9"/>
    <dbReference type="STRING" id="91928.A0A0D2BJW9"/>
    <dbReference type="GeneID" id="27330252"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03169"/>
    <dbReference type="HOGENOM" id="CLU_296300_0_0_1"/>
    <dbReference type="OrthoDB" id="4226255at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="179"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1019" mass="117543" checksum="625CCCC0A6A9B61C" modified="2015-04-29" version="1">MKPEQKPKLIRLIEKERIHFHGPSECRPGNHAQVFSAIREISSYKFDQYVHNFTYEAHQKPWRAKVKQKVERLVCLVENCRRAGQNEMGWRLKLEPEILARFGTEVTCKRCSSKLWRSEVEVSTNPSDNFGDILDLKTRQANRRPCSCSEMQRCLDRDDPGICRIFHDRADKVVKQSKSDPISDIFPKGQRPDRVYGFRKTSRFSRFLEEEISHPPFERQELRDVVECSPFNDMRDEVLFPFLVVEAKSETGNSFDDIEIQTAHAIKKLLDIQLKLRLLTGERSQWQSGPLVWFLSNRGDDWRVAAAYVEIQDKITHYHVYHLWGGSIRAKDAALQLLLIIDYIFDWARDFQREAVLNELRILTGREAVSIAGDSEIPSLGDPMRRFFEADLEQRPMENRIDSESLYPQGAAMYRWLDSEHCVFRSICWAHARISALYITTENLKTLLQSLPTDTVSRKCARDLLRLFREAWKVSPDALEALEFMWTGTHREDPDLYGAPQSFCAVFTVAAYFLSDWEQVTELTYIAIAENALNDLKEYVDLQQPIHVYPSELPHVQQEHLLGYFRHFRHGSARSRLHAAMRRRCLSSRLARERDFPDSFFLVAKEPFERGVRYRLDVTMLPDQKSKTRQLVAAIYSHCKRGMREPDESFLRMSSTYDSTPWSCQDMPSVWEVDDLPIHEGALCVLLGSDKVANNVDTNLCVYVMDDVPGPQAFRLGSNLLGSYFVVQTSQRKGLSGSQIEWNVDFVADPIPTLSIMSQQLQTQFRDLGILQKYQRMPNTNTKVARHPTYHATRELPPHMRDNLKHPLGHWVVTSDPSDTYDHARKLADCLVARKYNAKLIICLFAQPKVAGRAGLWSEQRRDKTTDEGMAELQEKLRQGWKPSAEDVGPATVIHRGDALHMPRRFLKRKRGVETQEDDRKVVLARGDWLTDAELALSIDSGTFDSSMLPTYRTTESVRKHPRTDRLEEPPRATDTAAETGATMERTASKRIVSKLMDYCPVTDEEFEALLEAGYLQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK39</accession>
    <name>A0A0D2BK39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_03582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239504.1">
        <property type="nucleotide sequence ID" value="XM_016377934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK39"/>
    <dbReference type="STRING" id="91928.A0A0D2BK39"/>
    <dbReference type="GeneID" id="27330665"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03582"/>
    <dbReference type="HOGENOM" id="CLU_161486_3_1_1"/>
    <dbReference type="OrthoDB" id="76305at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239163" description="Cytochrome c oxidase assembly protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW19288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8782" checksum="500CDFD8E04D3B46" modified="2015-04-29" version="1">MSTASKVTLLSTVLGTAGIVAFVHWAQTAEQAAMHAGVVRDMEQQRVKRERQADFEMQRQLEEEYKRTQNVRDSTTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKT5</accession>
    <name>A0A0D2BKT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239754.1">
        <property type="nucleotide sequence ID" value="XM_016374478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKT5"/>
    <dbReference type="STRING" id="91928.A0A0D2BKT5"/>
    <dbReference type="GeneID" id="27327193"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00110"/>
    <dbReference type="HOGENOM" id="CLU_132193_0_0_1"/>
    <dbReference type="OrthoDB" id="4878259at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1670.10">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="137" mass="15798" checksum="45B53344893C7156" modified="2015-04-29" version="1">MKTTPKIFYRQIGEIVFSSKPGRFVPKIFVVGDNIDPSDLHEVVWAEATKSPPQDSDFFFVGNYPIYKLVPYATYGLNTNEPQAKVVRLCMLPGEFKTLDRPWVEASFRSSFPEQIKKKVLESWQAYGYKTRDPLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL18</accession>
    <name>A0A0D2BL18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239869.1">
        <property type="nucleotide sequence ID" value="XM_016374593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL18"/>
    <dbReference type="GeneID" id="27327310"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00227"/>
    <dbReference type="HOGENOM" id="CLU_068979_7_1_1"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="30"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="221" mass="23606" checksum="FC999E768665A999" modified="2015-04-29" version="1">MGVAERVTDHVSLSNPPGYGKTLGWGSRPALLLIDVCAAYWKTGSPLDLSHNPEGAASPDSMRRLVAAARKGGVPVVWAQVRYNHPTMRDGGVQAKKTKTILAWQDGDTRSLDALLPGLEPGPEDTVVLKRNPSAFFGTTLATELRLLDVDTLVIGGVSTSGCVRASAMDAMCHGFRPMVVGSACGDRSPLIQQHNLLDIQSYMGDIVDEAEAVKRLSLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLW0</accession>
    <name>A0A0D2BLW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_09449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232390.1">
        <property type="nucleotide sequence ID" value="XM_016383767.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BLW0"/>
    <dbReference type="GeneID" id="27336532"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09449"/>
    <dbReference type="HOGENOM" id="CLU_003998_0_0_1"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.970.30:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit eIF-4F, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="1071"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="520"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="886"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="964"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1344"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="685"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1346"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1471"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1490"/>
            <end position="1501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW12174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1501" mass="159710" checksum="9993D2C37E24437D" modified="2015-04-29" version="1">MSAAVGGAPPAHGHSESVNGRNPTIPAIPSVNGNVSLPDHTRKTSMTVTPTGASGFPTNGTVPTGPQTKPGVTFGSFGNPSSSPAMGTPSLAHQNTSNLGVSQLNPRDSAASNSPSPIPQPSHLVGGRPPTSITGSSNGYTFGDMPVVPRDSGDQMMHRPHPQFGIQQEHMRRASSQSVHSDAGMQSAPNRGGGFQGGRGNKNFNNPPYQQPMQYSPHQSFRQPPNSRAMQGQYGGRGQQIPFQGSPAMGTRSPALVNATPGTPNMNQIHLVGSMQGMPGQPNGYYMGPQYVKHHPSQASSRDEPVRERGGRPTRGRGRGGRQGGRGRASGRGGHEEGPLFSRDPASDHYRPDLANRPAVAPPPSYFSYPDLSPESGNFEHFLTVRAQGFGLPTRADPSIEMHYQQHFQGQPSMQGQYPPQYMPPQSPRPPFQQNAFPPNMQGTYSNQGGPPSMSRQSSQMSAPDRPGSSVGQAPHTPGPSGPQQNARTPSASGQKPAYTIPPKKSAAIQIKNTAGEVVSFTKPPASPASATPVSAVALQTAPTPPSRTASAADNTHNRTDSASVKTAEEARKSMQEAIAKKIAEDEAKNKLEKESAQTTQPTRDTADTSVQQTSPSEAKAQDSDKPATNDAVEQPAEEAKPTEKAEPEKVEEKPKDEPVAPAKPDEDEIDFDAIEAELAAIEAEEARREEEYKKKKAAEAEAKRKKEEEEAAAYEANMKEMERKAEEEELAREKEKSTGATTDEASKKMFAELKANPFGTPASTESPAAHTPAESGTATPVSDVSMPPPTAKAPAKRGKAAELTLDTKKPVEPPEPSATLKALQSAKKLADLSKVQYPSDIASPSPALNANAPADRKFKYNKEFLLQFQSVFKEKPTLDWDTRIRDALGDGDTSARPSGSARTPSGMGGRNPSSRGPAAMSNFGGPMGSFGGARASLPPGTTSEQRFAASNAALRSGAIAGNPFAQFGRPGQMAPAMGRTPSSGPLGPIPGSPRVGGASRGGSRAESKRGKQNAKHAQEENKSMPLTAGMNITALETSATGWKPRSIGQGAAAAGPAPGGDGLMEPDVVQRKVKAALNKMTPEKFDKIADQILEIAAQSKHETDGRTLRQVIQLTFEKATDEAHWAPMYAAFCRRMLESMSSDIRDEGIKDKLGNVVTGGNLFRKYLLNRCQEEFERGWKINLPTAKEGETQEAVMLSDEYYIAAAAKRRGLGLVRFIGELFKLSMLTERIMHECVKKLVDYEGTPEEAEIESLTSLLRTVGKQLDDPESKGKGRMDVYFDRINHMIAIPDLPSRLRFMLMDVVDLRSKGWVSKEADKGPKTISEIHEEAERKAREAELQRLAQQGGGRGGGGRLPMGRGDARSFSGYGGQMPPPDTSNRVGTDDLRRLGNRTARNPSHTGAGTLGPPSLLGGRTNSGRRGLGPGGLLSRGDDSANSSRTGTPPAGKEKKDESSTNAFSALAGLENEAPGSPPSNPASPPTQKAQPNVDGDRARSPDKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM02</accession>
    <name>A0A0D2BM02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232435.1">
        <property type="nucleotide sequence ID" value="XM_016383812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM02"/>
    <dbReference type="GeneID" id="27336578"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09495"/>
    <dbReference type="HOGENOM" id="CLU_032992_1_1_1"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="2">
        <location>
            <begin position="9"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="341" mass="38375" checksum="B66A2BBCF9157D06" modified="2015-04-29" version="1">MPRVRGQFEKIFAISMPSRSDKRDSVAVQASLTNFDVEFVDGVAGDEVDKKALPWKMSQKPNVVGCWRAHLDVLQRIVKENIQSALILEDDADWDVGIRAQLTQLARGARYIQDVEEDAVSRSPYGDKWDMLWVGHCAQFTMKSDPRRWVITNDPTVEPVPHRKYWMENPDMSKWDHPDNAVNDTRIVFRSSGGICTAGLAVSLAGARKALLHMSMSPFNRPVDWGYDGFCKRKDTQTFCISSFPTLVGVSRPAGPRSKNSDITVHEGLFEKPQSERLVFSTRLNLQRLMTGATKFFNTYDPDIELTRDEIAAGIGHPEDAPDTSPEDEDVADTSPEDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN45</accession>
    <name>A0A0D2BN45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09806</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232745.1">
        <property type="nucleotide sequence ID" value="XM_016384122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN45"/>
    <dbReference type="STRING" id="91928.A0A0D2BN45"/>
    <dbReference type="GeneID" id="27336889"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09806"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_1_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF1">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="177"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="499" mass="55455" checksum="180C69149B51382B" modified="2015-04-29" version="1">MEITSTIGARKILRRYEDGSWSCEDVVRAFCKRAALATQLVNCCTELMFEEAISQARDLDRWYADTGEFVGPLHGIPLSLKDNHIVRGHDTTLGWVGLVGQPAEADELTVQQYRALGAIVYCKTNVPQSLMMSDSYNHVWGQSVNSLHRALISGGSSGGEGALVGARGSVLGIGTDIGGSIRIPAALQGLYGLCPSVGRVPNKESSKDQKYIIRPVAGPMSNSLGSIELFMEAYLSQDPWNANPGILPIPWRSELDEQVQNKERLRIAWIVDDGAVKPHPPIARAVRDVVERLKQAGHEVVEWDASDHQRAYYDLWVKGVLADGGRRFEGLCKMADEPLIQGMLVGTEETYLGPEERMELGDQIHEYKKAYLDRWTESGIDALIMPVTPWVGMRPKVWVKSQQYVGYTALWNMLDYSALTMPASNVDYVLDDPRRNDEWKAHGAQTRGFSDDFNYKMYQELWDDGVVQGLPVNIQIVTGRFGEEKAVGVAKVLEKLGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNB2</accession>
    <name>A0A0D2BNB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_09892</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232830.1">
        <property type="nucleotide sequence ID" value="XM_016384207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNB2"/>
    <dbReference type="STRING" id="91928.A0A0D2BNB2"/>
    <dbReference type="GeneID" id="27336975"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09892"/>
    <dbReference type="HOGENOM" id="CLU_005316_4_2_1"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="54"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="461"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="783"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="820"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="794"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="838"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="172"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW12614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="857" mass="95798" checksum="E4A328A32F530F75" modified="2015-04-29" version="1">MGRRGGRKGGFNRGGGGPRQDNRGNKAEISRTNEKFEEYYNTLGVIPDEERDDFWAAMRRDLPNSFRFTGSKAHALAVQQRLRDYYIPEITSITYEGRYVDTPQPVSWYPDQLAWFMTTPKNVIRRFPPFASFQKFLVAETDVGNITRQEVVSMIPPLLMDIKPGMTVLDLCAAPGSKSAQLIEMIHAGEEERSRQVAANTANGLDKREGEDFADDGRSTGLLIANDVDYKRAHMLVHQVKRLSSPNIIVTNHDATIFPSIKIPSLPDSSGKPVHNRYLKFDRILADVPCSGDGTVRKNMEIWKNWTPSNGLGLHSTQVRILIRALQMLKVGGRVVYSTCSMNPVEDEAVLAEAILRCGGEKFVELQETKDYLPGLKRTSGLTTWKVMDKSGRIWNDYDAVREQKATVGEEGLSRLSESVFPPKEDLHLERAMRVFPHTQDTGAFFIAILEKKSEIKARAEAKTSSTNSTAATPKPEKVETVDTTGEAVQLETAPDGTIDSVNGTAPPDADAPGKRKRLDQDEDTEDAAPLKRAKSEQDDTVPNGTANTSTTGRSTPAITAQAPRPGQPPKKKNREQPFEEPFKYLSPDLPELQQIREFYNLSPRFPQDRYMVRNADGVPAKNMYYTSALAKDILTENEGKGLKFVHAGVKMFVKQDAPSPEVCPWRIQTDGLRLLETWVGPERIVRLQKKETLRRLLVEMFPRFNGDEYKNLGEVGEQILAVKMGCCVLVVEPSDDPDGLSERMVFPLWKSIMSVNLMLPKEDRKAMLLRLFNDDTPLVNASKGWQKNGTKSAAEKKAAEKEETKADIETVIEAKNGLQVNQEEQIQRRRNSSSPELEAEANDDDEDGGVAIETDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNQ7</accession>
    <name>A0A0D2BNQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232980.1">
        <property type="nucleotide sequence ID" value="XM_016382277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNQ7"/>
    <dbReference type="GeneID" id="27335033"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07950"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="420" mass="46591" checksum="00E86EC36C7713CA" modified="2015-04-29" version="1">MYWLNYLDRNAIALARLNDLEEDLNLTSTQYQTCVSILFVGYILGQVPSNMLLTRVKPSYYMSGCMALWAVVSTLTAISKNFTGLLLTRFFLGITEAPYYPGALFLLSCFYTRKEIATRISVLYTGNILATAFAGLIALGIFEMDGFAGLAGWRWLFIIQGIATFIVALGAAFTLPDHPLQTRWLSEEERRLAHARIEKDTVGNKAATSTVQGLLEAAKDPKLWLFAFMQHMHLAANGFKNFFPTAVQSLGFNRTITLVLTCPPYLIAGFISVYWSYSSGRFNERTWHITTAKAVACLGFVVGCATLNTGARYFAMIVFSIGTYAVNSIILGWVGATCGQTKEKKASSLAIVNTIACVSFIWTPYLWPKTDAPRYTIAMSSSAAFSVATAAGAWVMKMWLIRTNKKIRQSSDETTLFYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP05</accession>
    <name>A0A0D2BP05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233060.1">
        <property type="nucleotide sequence ID" value="XM_016382357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP05"/>
    <dbReference type="STRING" id="91928.A0A0D2BP05"/>
    <dbReference type="GeneID" id="27335114"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08031"/>
    <dbReference type="HOGENOM" id="CLU_000604_45_1_1"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050334">
        <property type="entry name" value="Molybdenum_import_ModC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514:SF4">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="42"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="428"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="711" mass="78621" checksum="A6B7965859248ADA" modified="2015-04-29" version="1">MKRTPVLLFSCSRSARLNLVDIRNGTFYKEHPAHTPPSVNPPLFPNLSINVPAVVPQDKGKTPVKNETHWAVIGTSACTTFLEILRGSHLCFPPEARTYPYLASGYIDDTKDHQLRIPSRAIQYVGFNDGQGQAQKGGITGAYLSARYESRREETDWSLLQYLKGETELNPSQPAKEKRVDEKTLKKAIKDLRLQNLLDMPVSNLSNGQTRRAKIAKALLKKPKLLLLDEPFMGLDPPTLVGLSKMLLELSRRADPIILLGLRPQDPIPAWVSRLAVLGQDHTVSLIGLKKNVLHSLRRWQDLVSTLSSGRSSEEASNDEDARRIVKEFGHPPSGIGMKLTAEGITPFKEFSSEISPTAELSWRKAMSRRPGKGEQDDRLVDLLLRMSEKSIPQATTTVSPPASVDPSHTSSSHSPSSASRELGSPLIDLQAVTVKYGSKVVLGHGGGLTYTIKQGTRLALLGPNGSGKTTLLSLLTSDHPQSYSLPIQFFGRSRLPSPGVPGLSLWEIQARIGHSAPEVHAFFPKYLSVRRVLESAWADTYAGKPTLTPERESKVNAFLTFWQPELRQDRPAADADNSLNWANDKHTHAFGTLPFSAQRLLLLLRAIIKEPDIVVLDEAFSGLSAETRDKTMEFLEHGLKTPEFKGLKPTQALVVVSHVKEEIPPVVDEWLRLPGEDEVVESGRGVEGGRTERGYIRTNEGWMKVWGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP83</accession>
    <name>A0A0D2BP83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240954.1">
        <property type="nucleotide sequence ID" value="XM_016375678.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BP83"/>
    <dbReference type="GeneID" id="27328399"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01316"/>
    <dbReference type="HOGENOM" id="CLU_002712_0_0_1"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038769">
        <property type="entry name" value="MTC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1265"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1313" mass="145911" checksum="902A13A8F2F5475E" modified="2015-04-29" version="1">MSTSTSNPPNGPAATRVSEDPIDERKALPLPTFHSFQDPVRGETARPHSVASSSHNFADENHDHDHRHLSERFSFGSSIQSDGSKGKEKERGRRKENLSAPYQIPRNSGGFLLEPITNAKGGSRLSVTASRSDSRRKRDSTDSELSISKRRSRNNANLNPSFKSSPLASELRDEAVVHNKSAGGALIPGTDFRRSLSSSQQEPQTNGSATSRSRDDEAQSSRGASVGYDQDSVQIVQMALNLSEGRRRLASGRRYVSLDQGERRVVSTASTVDPRSTVKRKSIAPFLATSRQSSRTGSPKAKQSSRRLESKAPAMDDDLIDFDINLPDQISPATMARVEKAKLYFELAHEHRRLLSHLPPIRRPGAPAPSSGAEAMQKAYNPLQYVRNRKLRIWEKTSLDSEADGWHDIEKVRAWVDAVISSHSETQHDPLECVRLPPLDQKPAASDDQEQDGSPVEAKSAASPRIQDPYFSKPTRPRSDWVTHPADLLADAYWLEQGLNKTKIQDRDNNLIYPPNTHFRFSGWRNETPVEIPSTLRQQHSPTQQDVESGGPDEVPPSALPELPTFKSAHHKHTHRSKFRGSLPAKESSSSRERSRIRHKLFHDSESDGSESSSSEHNSTDRGRRRLRRKRLHSPLGKGTDAHRSDSPSKHSPHVNDSSQPSSTLNSKRSSVDHSALTKMLKIENLKKASPLSRSRHRDELSRPTSIKIPTRSSLDQEQPRRVSSEYDTTTAQNSPDVPQWPSIAINLSPPPSRGSSPARKHMSSILHPFHSKQDSKDVEHISATDFAHAPQAQPNQSAGETKHQSESNGSRGTSPMTRSLSPFSKPGTESTHTDDFGGLLSGDSKSTSISKVTTRSAGTGGSDHFKFRGIFKGGRIAELVGNEVSRVGDFIWKRDPPPPDHRHHMSISDSSLRSYRGSDSEKETGINGIVIKTPPPMRPLSRSSTVSSTKSERLLPTTSRISPMENGRPQYNNPNLPSFVSPFQRDKEQQQRKQALSPGTDGIRSDSTDHISRLAVQHRSSSRSPRLARLSLPKLDTGNTISPSELERKQSYGFGAAIDLSRSRDASELLNTALGSTTGLTGLHGSRSAGDLTRVPTTSEESESTGTSWRDIGRAEALLYSSAVKAREIGRRSEEEMPELPKFFLGTLNPVEKDLCMTQRQRCKRREYYIMAAKNIMRNLDQHSAVFNEKLQLFSSEVAPRLHMQLQQLEDMIENRMTPQIRTTADHAGELGMKLTTTSTLAVKELNDSIEKAMRNRRRGPIRLLRLLLFAGIEWTVVSLLWLIWAIVSIVRLVTGTFRTIGCVVKWLLWID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPC1</accession>
    <name>A0A0D2BPC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_00940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240581.1">
        <property type="nucleotide sequence ID" value="XM_016375305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPC1"/>
    <dbReference type="STRING" id="91928.A0A0D2BPC1"/>
    <dbReference type="GeneID" id="27328023"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00940"/>
    <dbReference type="HOGENOM" id="CLU_115574_0_1_1"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="146" mass="15911" checksum="27032045A1FD01B7" modified="2015-04-29" version="1">MTNRGKPRGLNAARKLVAARKEGRWADLHYKKRLLGTAYKSSPFGGSSHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVGLSALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPT2</accession>
    <name>A0A0D2BPT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233345.1">
        <property type="nucleotide sequence ID" value="XM_016382642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPT2"/>
    <dbReference type="STRING" id="91928.A0A0D2BPT2"/>
    <dbReference type="GeneID" id="27335399"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08316"/>
    <dbReference type="HOGENOM" id="CLU_000288_138_13_1"/>
    <dbReference type="OrthoDB" id="4120966at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="69062" checksum="4A24D37950CD6D77" modified="2015-04-29" version="1">MRLLDTTTLQLKEFADENEVEYIILSHRWEQDEVSLQQLPSLGTRSRKQGYLKIRACCAEAARNGVRYAWIDTCCIDKTSSAELNGTAMQPGAMRIYPMSGLSMILRAVFGSLGVGLYKSFWSTLLNPNQYTYRLTMAIQAPHAVEFYNRRWEFIGSKHLLSSRLSGITGVPRDVLWGDRPPSGCPIAQRMSWASKRVTTRPEDQAYSLMGLFDVNMPLLYGEGKKAFRRLQEEILKISQDHSIFIWKCTGNDGPLDMLAGSPADFADRRYVSPRYSGSEQYLMTNAGLSITLPMLPWNMNTYLAILGCNHQRGVRARADGYCSAIFLQRTKNPRLLIRVALSGQEICTVKRRAVSQIIRMQQVLILSPRVPAFPDSDFVYGQPAYGFVFLSSMSSHLIDIGPKGLPGVEIGSRNPPEPYQTSLQDKPAWKVKLLPGQHGTVAWFDFAKTEKPPGKIRLVKFGFDFEFNPVCMIWTHDHLSRNSWVDQQGRALESSTLDSNEWIEKDVASHGIDVSSGYTEVGGELRPYYALRGDNSSGISVGIQALELTIDIATGRGDRDPEWFVTMEDTFDFEAQDKSEFYRRDRRFGWRSKKDVIVEERVEGDVDTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPU0</accession>
    <name>A0A0D2BPU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240726.1">
        <property type="nucleotide sequence ID" value="XM_016375450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPU0"/>
    <dbReference type="GeneID" id="27328168"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01085"/>
    <dbReference type="HOGENOM" id="CLU_2250191_0_0_1"/>
    <dbReference type="OrthoDB" id="4121142at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="104" mass="11622" checksum="BE155DA297ED8FB0" modified="2015-04-29" version="1">MLLTSQDSDVQTKGLQEPSNMPMTDTERALMLFLTAVGFFFISLIWNLYVQFGWERDGVGQLDKHAAGAMELDRLASRQPRFHQGLGRENGVMAAAAYEIDRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR09</accession>
    <name>A0A0D2BR09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241649.1">
        <property type="nucleotide sequence ID" value="XM_016376373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR09"/>
    <dbReference type="STRING" id="91928.A0A0D2BR09"/>
    <dbReference type="GeneID" id="27329096"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02013"/>
    <dbReference type="HOGENOM" id="CLU_013838_2_0_1"/>
    <dbReference type="OrthoDB" id="5344325at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="664" mass="74466" checksum="B43D71E2B583EDF5" modified="2015-04-29" version="1">MAQAHRQGFVSTFPNRRRPITVCLECYRRKLKCNRVKPCNQCCNRKAPETCCFADDVSPSQSAPTPQAGFDHPEIHSNVDASSQISIAEGLVERAGYSATSASSTFLRLSDESVQGHHQTLLSLSQSNLQGFHDEYRHLVSKLPLPAQVHALFDCFFQEIFWTSVPVDEHRLKDLYNDWLSVPVDEHLNDELNHSRRDLLYLPALLFQVLANIVLHLTPQYGPAKALGLGQHSDCARLSRTFFLFGNRLMFILGRQHPTLCSVEYDLVACSWLKDSGQGKEAWHSLANAVRQAQELGLHRLPQNIAPPGLGQELYPMSSYDLEQRKKAFSTLFTYDSIGSFSLGRPRLMHREDISTPAPTAWKCHQDVTGSVQLSDESFHDAASMLFLSLAHRIHDILSLSANGIFVSDYLKVLEVHDQLSSLRDLMLHLVPENNWGKATTPEMLRRSHLRLTLLSTANAVMVALHRPFIGSHPSSHSAAVSAALDGLDLQHSIFDLIPHSHVKQWATTLSIIEASVFLCGIMMDGPPQDAAEDRRIRQAILLAIGRLSSTKDLNPLAEAGEQVLRQFYQKIQSARQPMLGHGEWHQHSTTPQTWLEQSGQLHDISIPSPQKSPQEIYQTLFGDQLVSLNSLGLSSSEDSPFEYGAYSIPEEIIDSEYFHWPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR87</accession>
    <name>A0A0D2BR87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241739.1">
        <property type="nucleotide sequence ID" value="XM_016376463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR87"/>
    <dbReference type="GeneID" id="27329186"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02103"/>
    <dbReference type="HOGENOM" id="CLU_719682_0_0_1"/>
    <dbReference type="OrthoDB" id="4119985at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239177" description="ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43521" checksum="B1D0FFAA3207C4EF" modified="2015-04-29" version="1">MPPLHMVFAFTLLILGVSNVVYAAVASLHGTGLVNSTDLECRQCVKNQQTGQYRCDYNLPSVGQTVARCRDTNDRGRVAPENVPWFYTHLWSAHDLPTDQESVAETAELAKRDEVRERAPSTAQIQTIESTQLFETPQASRIFSPNHADSNDTSAGVTPFRFHSDPGHAKELHPRQCLERAQPGVWDCDFAFPTLQQFIDRYRDYANWGMATPGRSVWFYTNLDQTNDATVFPNCYGWLLMNNIDSYYGNSGLSSLWLAAQVEWIEDHRAEFLAVTGGQDPMKVFSVCLFEALALSTLNPDAYVFTKAPPETWRDTSWWALIEYPALTNNPIVQRIWRVDPRPGQCNDRILIWQRGRDLPLQMFQSCQVLEQLRAPNPAATAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRE7</accession>
    <name>A0A0D2BRE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241201.1">
        <property type="nucleotide sequence ID" value="XM_016375925.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BRE7"/>
    <dbReference type="GeneID" id="27328647"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01564"/>
    <dbReference type="HOGENOM" id="CLU_000845_0_0_1"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05702">
        <property type="entry name" value="S1_Rrp5_repeat_hs11_sc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05703">
        <property type="entry name" value="S1_Rrp5_repeat_hs12_sc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05696">
        <property type="entry name" value="S1_Rrp5_repeat_hs4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05706">
        <property type="entry name" value="S1_Rrp5_repeat_sc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05707">
        <property type="entry name" value="S1_Rrp5_repeat_sc11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000159">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000266">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000278">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000279">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057301">
        <property type="entry name" value="Rrp5_OB_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048058">
        <property type="entry name" value="Rrp5_S1_rpt_hs11_sc8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24685">
        <property type="entry name" value="OB_RRP5_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="153"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="272"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="457"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="548"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="642"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="729"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="825"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="936"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="1044"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="1131"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="1225"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="1314"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="1626"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1419"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1419"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1520"/>
            <end position="1529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1823" mass="201595" checksum="FB667CA44326920C" modified="2015-04-29" version="1">MAPSKRKLAGDEVPASTANKRSKSETKSEAKTKKQKLGADQETTQKPKHVSVLTKEQPAFPRGGAGLLTPLERKQIQVKATRDVARERKSQDLFGGTSTQMDTSDEEQTSPSDVEQKKPAKKSKKNKRRPESSTADAPDVQIGGLNYKRLTTDSLILGQITSISTRTLTLALPNNLVGYVPLTAISPQFSEKIQALIKGDADHSDEDEDNDDEVNDIALANYFKIGQYLRAAVTSTEQERGAGRPTARKRIELSIEPSLTNIGLKRTYLTTGATVQTSVRSVEDTGVAVDLALNDNEETLRGFIPKKELPNNLLFSDIRKGTVLLCTIIESGSKGKVLKLSADLSKSVTVKSAPSIDAFLPGTRAEILITHRPDYGLAGKIMGMLDVTADLVHSGSYKDKEAFLAKFEVGKKIPGRLVCNFPTSDVRKLGFSVLEDLIDMKPDDGLSTKADGKLALSSIIDEATVVRVEPGLGVYLQLNEDHVGFAHISRLSDEKIDTLSEITGPFKLGTDHKARILDYNPIDNLYVLSLEPKVLSQPFLRFDDVPLGAVVKGTVEKIIIGSNGVSGLLVNLAEGISGLVPQIHMSDVDLKHPEKKFRVGQTVTARVLSTDPARRRLKLTLKKSLVNSDQKPWLNFDDIEVGNSTVGTLTKVDRFGAVVRFFGPVRGFLPVHEMSEAYIKDATEHFRVGQVLTVNAISVNAEERRLTVSCRDPNANPSTESALSALKHGSLVSGTVFEKSQNDILLRLEGSDSIARLTLDHVSDGSPSKRASAFNKIRVGQKLENLVILQVQAKRRLVVLTNKQSLVKAAQDGTLLKSYEDLLPNALVTGYVSNITEDGVFVTFAANISGLITRNQVPVDQEDQPDFGMAKFQPVTARILSIDYKGATPRFWLTMRDSTIVNGASKPPNEDSALPLPDVVEPIDTSLRTLNDLSVGKITKARIISVKETQINVELAKNVQGRIDVSEVFDEWKDIQNRKRPLKQFSPKQELTVKILGAHDTRNHRFLPLTHRQGKNTVLELSCKPSSVTKPGKAILKLQDVSVGSSWLAFVNNITEDCLWVNISPSVRGRIRITDVSDDLSLASNVEANFPVGSALRVHVVSVDAEKNRLDLTARSDASVGSLTLKDISKGLILPGRVTKITDRNIIVQLSEHVVGAVDLIDIADNYDEANTAKFQKNEVLRVCVLNVDVPNKKVTLSTRRSKVLSSSSPVTDPEITSIDQLAVNDVVRGFICNITDKGVFVTLGHGFTAFVRVSHLSDQYLKDWKDHFQREQLVKGKITLVDKASGHVQMTLKQSALDPNYKAPLTFGDLHEGDIVTAKVVKAEPFGVFIVVDNSENVRGLCHRSEIAEQRIEDATKLFSEGDAVKAKVLKLDPANRRVNFGMKASYFADTADSDAASSDDNDEDGVNLDEIMEDVDDEDVEASEDDEDPVQVEFEEAGDTDEEEEEEDEADDSELEDSDDDEAGPARRKPQGLSVGGFDWTGTSGLVDTKATKRAADDSESDDEQDSKAHKKKKKKRAEPVVDRTADLDTNGPQSSDDFERLLLAEPDSGDLWLQYMAFHLGLEEVDRAREIGERALRSIGLGPGSEEEKLKVWTALLNLEDARGDDESLDAIFKRALEYNDQQQIYSRLASILIQSGKYDKATEKFNEMLKKFKADLDVWVNYATFLFDVVNKPGEARELLPRASKTLPSTTKDKKEENRARFELTKSFALLEFKSKNGLPERGRTLFEGLLAEYPKRLDLFNVILDQEEKLGDHDKVRETYERVLSVKLKQEQARHFFKRWEKFEAKHGDQRKVEDVQARAVEWVRNYTARQQQQATTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRV9</accession>
    <name>A0A0D2BRV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234170.1">
        <property type="nucleotide sequence ID" value="XM_016381068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRV9"/>
    <dbReference type="STRING" id="91928.A0A0D2BRV9"/>
    <dbReference type="GeneID" id="27333818"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06735"/>
    <dbReference type="HOGENOM" id="CLU_031808_0_0_1"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="606" mass="67823" checksum="102139FC0295356F" modified="2015-04-29" version="1">MPPPPKARPIKPAKEAQPPKLTPSSKKKQASGRISAACEACKKRKTKCTGGPPPCHLCENLGTECVIDLSLDMRRRAALQRTIDESKSYQDTLNRLMDAIREGPSPRLDNLHEIIRNSVNNQETTNTIQRYLRESDDQGSDHTLASQSDAVGSFMDESIEVGPEAMNINGELTTPSPSLAINHEKIMNGVLKVEPPQSMVPTLDRVKTRPGTPNIGSLLMALKTCSISEGEEMLRRLIASSPVETNASSPWSTTSVKNMLEQIPSKTISTGLAERSSWHPALQLRSPTMMAWPEGKTEIVHVEQNHKRRFSEAAPQSKRPDPNVMRSQQPSMMRRPSFPQPAQLNTDIPMVPVAHPSPHTPYLEVVSSPLIHDPAPNRWDLSVAQDKQSTRLRIPRHLVLPLIIHDDSYMSRTYTHYLQGARQMLDGGVPMMDVLGSDDEISVDLFFRSRTKTDKFDCASWACEVTRSYETEVYTRLGSAYMLTLLMRWLLVSTAENYQKVPDMVRPTPSQCMIPHIGAIETIPLGPVRDAAIHRLRDWLTPLIKCNWSVNWHHGMEAAVQQSLVTGAKVLTPRFIEHVTDYDNWSVGSVFLETFPEVVGKIKIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVP9</accession>
    <name>A0A0D2BVP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235585.1">
        <property type="nucleotide sequence ID" value="XM_016379758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVP9"/>
    <dbReference type="STRING" id="91928.A0A0D2BVP9"/>
    <dbReference type="GeneID" id="27332498"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05415"/>
    <dbReference type="HOGENOM" id="CLU_360207_0_0_1"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239347" description="Kelch repeat protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="575"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="688"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="759"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="86483" checksum="AFF98F2C727C36CA" modified="2015-04-29" version="1">MLLVLRYASWLLSLAVLASCDYTSKQIASWQRPRASLIRDYVYLEGGKIQTGSWDNQLQMWNTDDVVTTTQGALFNLSLHKPFGANEGDDPAVFQSIPEVAVNNFYVDGFMFASYDEFYAWGGMMLTSLNTRDRTVHDVLYNEPDGKSDADLGVPDTGYDPQNSNFPHGVTNGAGANAPSEKLGFYFGGLYNQNGSKYDYFDQPEDEANFLIKVTMDTIGDSDWGIFTPPDDAKIPWRAEGGLVWIPTSSQGILVALGGVVKPADANNYYHVDNVTTSMTFVKEFPVYDIGSNIWSLQPLSDGSPFPDKPIAQFCTVVASAADYSHHEIFVYGGWDSNNDTTPSSDVWILSIPSFTWIKAASSGREGDPRIGHVCVTPYPDEMIVIGGTGFSESPLTTSRTVDVYNLSTLEWTGSYDPDVHDDYKPNQVVLNAISATPTASGMASDVANWFDTKYDTSKITNFGPYQKPAATTASNGTSTPTPAPHSHHRDWVVPVAVVVSVVGALTLSGFLLFMCFRKRIIERRRRILREREDSIAAGNRKSYILPWIFSTSSAAAPKDVGSDTITEVEPAGSPQVLARGPHEMDSSGGNRNDYFGGSQPRWSSSTAVRSPRADWEGPAEAQDTGIAAIHEVSGSPMSEKPDGINYHFRNMSMYPPSVVSGGHHNIPAAQSATISYADESESVSAATASVSPRSASATNISSPRGVPTIPEDGGTTLDNSGNGTASGPGGAAVLGPLDPVSPLTNKQQRRPLHNRHNSSVSSGVSIPSLGVDQSSPLPSRPRSLSTEEDKGEGEVKGNQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWH8</accession>
    <name>A0A0D2BWH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_05672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235840.1">
        <property type="nucleotide sequence ID" value="XM_016380013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWH8"/>
    <dbReference type="STRING" id="91928.A0A0D2BWH8"/>
    <dbReference type="GeneID" id="27332755"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05672"/>
    <dbReference type="HOGENOM" id="CLU_010595_1_1_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW15624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42001" checksum="123F4941DB8D7D82" modified="2015-04-29" version="1">MSDAGSDADTIAPSVFTNTTTTAISAVTTTQSMDSPMDPDSNSALSDEASFDTRSLHASVLDYPMFWGRRYHRYKEGSYLFPNDEDESTRLDDQHEIFNRLHHRLFFAPLHPDNVYNVLDLGTGTGQWPIELADSNILPHAEITGIDLSAVQPVDVPSNVCFEIQDCSDDDWLRPLDSVDFCHARFLAGSLVSYRDMIRTARRYITPGTGWMEIQELHPTPVSDDNTIPDRWPLKVWDDNLHRAAARALDPPRPVRVASHLKSWMEQAGFVDIHEHVSKIPLGSWPKDPHLKDIGTWWLENWLSGLPGFTYKLFGVEGLEWTREEIEVMLAEVRKAAKNKAVHAYQRVYVVYGRRPSKEEEAMIWGNGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BX22</accession>
    <name>A0A0D2BX22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236070.1">
        <property type="nucleotide sequence ID" value="XM_016380243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BX22"/>
    <dbReference type="GeneID" id="27332987"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05904"/>
    <dbReference type="HOGENOM" id="CLU_486590_0_0_1"/>
    <dbReference type="OrthoDB" id="4160065at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="539" mass="63479" checksum="7A69261A08ABA546" modified="2015-04-29" version="1">MIRNTPPKPSSRRRRHSRKYAPSSEEFPEPLDKKKQEKNKVERKPRPPGLSELLGSYFVTGGRAGDNTRAELRTIERDIVEREATRPRDPKPGEIVFKEPPRPEAVRRERIKIEQAQAEVLRETRRREEVDLILRRHETERQTWEQELRQREQEIRKYEAELQRLKYERQFETLHREQEDKLRRKEDEYRRREEDFVRKHEAELRHYKRERDVEVQRHESERQPHQVQVDHHSEPEIIVREQNPRSESRGRSRHGTDSDSDDRPPDQPEPRPGLRGGGPSGGARYRAETEPEDLIYIFYVRYGEIKEISTDLSPRRQGGIGRWTDKRLLTHLVERYRRQSGNEKWWTWRYWWDSFMKEIAALILIQMEESTVFYERIPYPGERQEPPITDLRRRVKRSIDLFGGKEASGQFRYLIRHYKTMTDSSRIITSQIDRLAISGQQDHAESAHYKYYLLLEVVEGQNGQAFLLGILIIILCFLAFGLALGATQASSISWGDVFSISGFGLAALSGLFALMGLAQYLGLEDMSPGNPISRDTAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZE2</accession>
    <name>A0A0D2BZE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236905.1">
        <property type="nucleotide sequence ID" value="XM_016378228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZE2"/>
    <dbReference type="STRING" id="91928.A0A0D2BZE2"/>
    <dbReference type="GeneID" id="27330960"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03877"/>
    <dbReference type="HOGENOM" id="CLU_035045_0_0_1"/>
    <dbReference type="OrthoDB" id="3166386at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="596" mass="67719" checksum="79C5B46A0550AC68" modified="2015-04-29" version="1">MASATDIITYVGVPLAVLGVLPILYTFMLAVLTQRRIRASLLCHGHRPVSRTRPNDGFTIRSSPMTSLIEVELPKYTIAPLERNHDDYWKSTDAGEEQTGEEHRLLGRAETTMSMMEEGRVLGFLRGGSWRAFHWKRLMVGRKLYRIQYEDELREPPAEIEFSDLIHFLLDWGAVPDAMGWEKLKSGGLWTPAGTTLLRKPGDAEDKTAGNADWVLRTTMPDESDGVLSVTIRWTKETTALTDTRGVASLPPGWGRLNQPRQLEPRDKLKEDVKDLPSRIEEMKAADKYSIDSSSLRFRTEDNRVQRIHWEQKHVETGFIREPFPTYERSVASLWFTCASSALLSRKQSSGGLWAFEIPAEIRTFVRKESIPCGVLVTLGILAETDAPQWSSEPESAVRDATMNMSNRHFQRFQARVAAERLEATMPPEQARIHRMNREAAERRDQMNDMTESLRFREERNERRIQEAIASPRMSIKAAFEACLAWLIQQGEVGREWTLEQLVEAILYLLVVDQSNNDQGEARKVSRILDEWQAWTTAGGMKKQQVKLLEENKTAFCFAAALVAVVSECADSDSGHGKAGADMLECLRLWRKVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0E0</accession>
    <name>A0A0D2C0E0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_04260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237285.1">
        <property type="nucleotide sequence ID" value="XM_016378608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0E0"/>
    <dbReference type="STRING" id="91928.A0A0D2C0E0"/>
    <dbReference type="GeneID" id="27331343"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04260"/>
    <dbReference type="HOGENOM" id="CLU_039329_2_0_1"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="7"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW17069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="333" mass="37287" checksum="C1D49D74F5038EE5" modified="2015-04-29" version="1">MSRYVKIDCHSHYLPPGYRDACAENGHKNPDGMPAIPPWSPEAHLDMMKAVNITKSILSISSPGTHLVPGNLDLTRKVTKYCNDYASDLKKQKPEQFGFFASLPLSDVEFCLQEIPRALDELDADGFAVMTNFGGSYLGDKTFDPIFELLNQRKAKIFIHPTTPCLKDGTAATPLPHFPRPVFEFLFDTARAVMNLFMSGTVSRCPNVTFLVTHVGGAFPPLINRFSAFASAVKVPGVDSSVNPQWVKERLNKQFYFDSAGWSLSEQMKGMLEYVTVDRMLYGSDFPFTSLPYVQVLSDMHDQYLPEVFPRDEDQEKLCSKNALQLFGSKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3W3</accession>
    <name>A0A0D2C3W3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1479 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_02617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238545.1">
        <property type="nucleotide sequence ID" value="XM_016376975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3W3"/>
    <dbReference type="STRING" id="91928.A0A0D2C3W3"/>
    <dbReference type="GeneID" id="27329700"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02617"/>
    <dbReference type="HOGENOM" id="CLU_011148_0_0_1"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="48606" checksum="755E0A9E6A84BB07" modified="2015-04-29" version="1">MPGKLVSSWPDWPEFTASKAETGDDLIAFKKAIVDQYGQEALVKSWLKVCKELESVTDNIAELGSSVIPEVSFDDVFTMSAEKKEELKNVGCFVVRGVFSEEQADEWFSNLKEYVAANRASIGGWPAETPFILNLYFSPSQIAARSHPNQLKLSAELNSWWHDDEGTTTPEPLSYADGVRIRPPGVPFLGLGPHIDAGSLSRWADPMYRSFYDAVFSGRPEELDSYDLTTRKKANQAMFPGSAHSRVFRSFQGWTALTSAGPGEGSLMLYPNIKWAMSYLLLRPFFQAPADEADVMDASKWTFDADRSWFPGTFKDDSQLLSPSSHPHLRLRECMVGIPRMAPGDTVWWHADMCHAVEVDHNGDHEASVAYIAATPRTEQNMSYIKGQLQDMLNGIPPEDFRNGSAEKDFKMFTGEKSNLGGEAGRRAMGFDLIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C4Z9</accession>
    <name>A0A0D2C4Z9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_02958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238885.1">
        <property type="nucleotide sequence ID" value="XM_016377315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C4Z9"/>
    <dbReference type="STRING" id="91928.A0A0D2C4Z9"/>
    <dbReference type="GeneID" id="27330041"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02958"/>
    <dbReference type="HOGENOM" id="CLU_081631_2_2_1"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25385" checksum="49B958DD043420A7" modified="2015-04-29" version="1">MGATEIAILPLQEGKTFDDPTTADGQLHAELLKIVLAQPGCQRCYWGRQVEDKNVLRWFVDWDAVESHKQFMASDVYKPFLQSFLTILGGRATLYHAHFDPHPARAALSKTTSPATEIIHMYFPTSYSEEDKKKVADDIKALSAVLEKEGSDFRAAASGWVEEDVDIPGTDEKAKAFVVLFGWTSVEAHLAFRETKPFAENIHLLRGAKDLKKVHVVHSSLTEATNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C5U2</accession>
    <name>A0A0D2C5U2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pre-mRNA-splicing factor SPF27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239135.1">
        <property type="nucleotide sequence ID" value="XM_016377565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C5U2"/>
    <dbReference type="STRING" id="91928.A0A0D2C5U2"/>
    <dbReference type="GeneID" id="27330291"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03208"/>
    <dbReference type="HOGENOM" id="CLU_082523_4_0_1"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23699" checksum="1BE5B076ED644E78" modified="2015-04-29" version="1">MSLVLESNESLPYIDPEPTAGQKERARALIDKELPADYLTTPHPSLPPLHETKFSESMSKELERVAAGQPMQGGIDMGRYEAPENEDIVDLDVKAKRLALRQAYVASTFLSGRQDNLQLLDEHGKNAWLVSNDRAEEILKDLERTLAMLKSETDAINKSRKATQEAHKAELLGLQDAWRRGIGQILETEVATEELRQLIYDRQRQQHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8Y7</accession>
    <name>A0A0D2C8Y7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240210.1">
        <property type="nucleotide sequence ID" value="XM_016374934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C8Y7"/>
    <dbReference type="GeneID" id="27327652"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00569"/>
    <dbReference type="HOGENOM" id="CLU_897251_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="310" mass="33276" checksum="D5DE6F5410CC8E81" modified="2015-04-29" version="1">MSWPLFIGISAVVFYVLGGSLYGVFCGHGNNDYYCTFEVCVPGIVFLCLGGVCTIAWVILFASYLKGLRKNPAGSINPSKSSSKWRPLGSGIAALAAFVIGGALMGILQNTYHDGVFIAGCAFLGLGVLLVVIFIVLAIVYANPPNRNPATQGTSGLHASSRIKYWALGFGILSLILYGVGAGLLGYFYSTVSGEVDNLDYYSNGGEYSRQVGGFVCVGLGSIFTFMWLVLLAISSSRKRCIQPVYIVAQSSMGHPRPVLSGEEVENRHTQQDQELGRYCGMCGKFVQTPFCRRCGTPQNTFSSDGRTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAZ2</accession>
    <name>A0A0D2CAZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240960.1">
        <property type="nucleotide sequence ID" value="XM_016375684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CAZ2"/>
    <dbReference type="STRING" id="91928.A0A0D2CAZ2"/>
    <dbReference type="GeneID" id="27328405"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01322"/>
    <dbReference type="HOGENOM" id="CLU_000134_34_2_1"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="159" mass="17090" checksum="78555EF663949B00" modified="2015-04-29" version="1">MDFAPHTSAEGGPPTADELPPEVIALASRFFEAARNGQMDIFEHALPQGLPANLTNDKGDSLLMLASYHGYEALASLLVEHGADPNRLNDRGQSILAGAVFKNEAEIIKLLLRAGADPELGEPSALDATKIFRQEEYEGMFREQMQKLKGVGTAAVNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y419</accession>
    <name>A0A0D1Y419_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_12044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="KN847504">
        <property type="protein sequence ID" value="KIW09701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229917.1">
        <property type="nucleotide sequence ID" value="XM_016386351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y419"/>
    <dbReference type="STRING" id="91928.A0A0D1Y419"/>
    <dbReference type="GeneID" id="27339127"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12044"/>
    <dbReference type="HOGENOM" id="CLU_010089_0_1_1"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF10">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW09701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="469" mass="52273" checksum="96B4702A2BE5D6B9" modified="2015-04-29" version="1">MQTPEQIFSNYAISPRRGFLADIPPLERLPEYFAPWETLAADLPSLIAKRQVRGNIDGLPVLETSGLVHKAEWQRAYSLLGFLTQAYIWSSSTPAEVGPLNPIPESFCIQADENDQYLPPSISRPFLAVAERLKLPPIANYSGLVLWNFTFKLSGCDPTNPEHIQALTTMTGTKDEEWFYMISVVVEARGGPLVAATVRCLEAMSQNDDPGILSAVESIANGIRDLTRLLSRIHDHCNPRVFYDKIRPMLSGTKVSSFDVLRRGVFYDVGDGHGLWRKYSGGSNAQSTLIQLLDIFLGVPHLGRDKTLTETPSVGSSVAPGGFLEEMQSYMPQEHREFLAHIAQSGSLRRYVAKYCTDTDIYRAYNDVVEALVSFRSVHIQIAARFIIQPSKGLLHPPTGDFRGADRVLTTRTWSPPDENAIRPELRGTGGTEFMSFLKKTRDETRDTVIESGDQGCELDRLSLASHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y476</accession>
    <name>A0A0D1Y476_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229977.1">
        <property type="nucleotide sequence ID" value="XM_016386169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y476"/>
    <dbReference type="GeneID" id="27338944"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11861"/>
    <dbReference type="HOGENOM" id="CLU_011910_0_0_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="402"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW09761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="850" mass="95842" checksum="1B33D0A8DAE50781" modified="2015-04-29" version="1">MLHKERSQHLRYPGQTPQSTAQVDHIQHYVTRVEYSMRANPAGSKRRNATEKSQYVGVVVDWDLFAFMETKSGTKQRSTSRRAHISQTIEPDRGCGRIGQKLADCEALLKVLANRVPEPEAKLIKAYLGEETARNSDTQDTDVEAAPRSGTNEHRGTYATSSEGSTEPALTGETPYGTKEDFTRKGATVTGFMGPTSEVTWMQTVLNDNNLDDLRLTSTHSPSDAERTYADFPLSRSGQLLGNHRAHLAEADHSFTINSMSYHLDDTPLSALERVEPYDMPQAETAQFLFYTYLQHAHSTFPVIGKSTLTSQFHRFLSNPFQRPPDLWLAIINTIFAIAARYASLVRPDRHGNIEDHLVYFNRARYLAINSETLFDFPDLQLIQVFGLMSFYFLCTSQINRAWVLIGIAMSHATALGLNLRNDSTQLKDQLKEIRYRVWWSLYVLQHRLCIITGRVTCVFDQQCSTPLPVPLEENEFDTDRGVELLGKEYQQGPRAPPSNMLARNRSTSTSFTDGDRSFPPHQRFQSSRTISMPQVGLSWAKDVMANPSLYFLHLTQLARLSQSILSQIHSVATSPHLQSRLEDIEIQLEDWARNLPPVFDFRCNNKEQSSRELRLSLGFFYYGTQLITYRSVLDGFPDLNITRQSKDSDTLDCSAATRCVEAAKAIIHLVPDESNAEGIMQCGPWWSVLPWLVQSTSVLIHWLSFPVYRAAEGFRDTFETLKRAIRLLHVLGEHNLSASRAWSRCDFTLRAVAAKADMDLNDLPEQTIFHGAPSAHGTLNTIGVASHEATTLFQHYPSAHTILTTTQALSPPQSLAGLNGLMLFDPQLGWSEHVELSRADGEFHQHATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y9C2</accession>
    <name>A0A0D1Y9C2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231787.1">
        <property type="nucleotide sequence ID" value="XM_016385185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y9C2"/>
    <dbReference type="STRING" id="91928.A0A0D1Y9C2"/>
    <dbReference type="GeneID" id="27337955"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10872"/>
    <dbReference type="HOGENOM" id="CLU_1686592_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="156" mass="17438" checksum="BAD770886791D936" modified="2015-04-29" version="1">MTATQLFSYSDDQWARLDGAFIMCAHSLHTGQAPVTKTDTTADLDTQRQPPRSITGHNGERKAIIQAVVEGNWRKIDNDIVRYNEMWAISKFPADIKNDGSLQKTRTIMSVSLPVASQSGKVIKASDTLSNPENLQYYYRFAKDETLLDAVSKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YBB9</accession>
    <name>A0A0D1YBB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232442.1">
        <property type="nucleotide sequence ID" value="XM_016383819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YBB9"/>
    <dbReference type="STRING" id="91928.A0A0D1YBB9"/>
    <dbReference type="GeneID" id="27336585"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09502"/>
    <dbReference type="HOGENOM" id="CLU_057540_1_0_1"/>
    <dbReference type="OrthoDB" id="5342507at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29165" checksum="C2FECF2ED2120BE2" modified="2015-04-29" version="1">MAFGGALLRFGQTGLRILEFACAAIALGIYSYFLAVLSNHNMRIPTWEKAVEGMSGAACLYLIFCILLTLFLGAIRFFAFIAIVLDVCFVGCFAAIAYYTRHGANSCRGFVNTPLGRGIDNQSAPGAGDWGYVCSLNTAVFAVSLVNVFLFLITAVVQFLLARHHQKEKRFGPSPSNNYTSGTGRRPFWRRNRNKDLPRGTRDAEMASAGAVAADPTHTNNYHHGTTVRPSHETGMTGSTVNNGGSYPLATEPKYGQPGYGNTTHGTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YBH0</accession>
    <name>A0A0D1YBH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RuvB-like helicase</fullName>
            <ecNumber evidence="17">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PV08_09558</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">May form heterododecamers with RVB1. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="17"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232497.1">
        <property type="nucleotide sequence ID" value="XM_016383874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YBH0"/>
    <dbReference type="STRING" id="91928.A0A0D1YBH0"/>
    <dbReference type="GeneID" id="27336641"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09558"/>
    <dbReference type="HOGENOM" id="CLU_028311_4_0_1"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 17 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 17" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 17" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="68"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KIW12281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="473" mass="51511" checksum="D63916131184300E" modified="2015-04-29" version="1">MAAPITTVSESREVRGLNLVAAHSHIRGLGVDLATLEPRGTSQGLIGQQKARKAAAVILQMVKEGKIAGRAVLVAGPPSTGKTAIAMAMAQSLGPDVPFTMLASSEIFSLEMSKTEALTQAFRKSIGVRIKEESEIIEGEVVEIQIDRSVSGGNKQGKLTIKTTDMETVYDMGTKMISSMTKERVMAGDVISIDKSSGKITKLGRSYTRSRDYDAMGADTKFVQCPEGELQVRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIRSEVRDQINTKVGEWKEEGKAEIIPGVLFIDEVHMLDIECYSYINRALEEDLAPIVIMASNRGNTRIRGTTYSSPHGLPLDFLDRVVIISTQPYASEEISQILAIRAQEEEVDLSADALALLTKIGQESGLRYASNIITTSTLLSQKRKAKEVSIDDVQRSYKLFYDPTRSMKLVSDFEKQFIGDSGQVSFSVNGSNGTNGDAMDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCL0</accession>
    <name>A0A0D1YCL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_09944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232882.1">
        <property type="nucleotide sequence ID" value="XM_016384259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCL0"/>
    <dbReference type="STRING" id="91928.A0A0D1YCL0"/>
    <dbReference type="GeneID" id="27337027"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09944"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF7">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="76"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW12666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="562" mass="61603" checksum="C810B24C8F8F7929" modified="2015-04-29" version="1">MAPSWEERASKKRESILASIPSEWRLPQPLPSPEAQKAVAGSYVQQFLSAREIEITESDAVTITENTTAGRWKATEVVTAFCHRAALAHQLTNCLHEIFFDQAIEHAKQLDATFAASNGPIGPLHGLPVSFKDQFHIKGVETTMGYVGWIDTFEGVTGTGKEKEVDSELVREVKALGAVPFCKTSLPHTVMSGITWNNIVGFTLNPHNRLLSCGGSSGGEGALIGMRGSPIGFGTDIGGSIRIPSAFNGLYGIRPSFGRFPYAGVANSMPGQNTIPSVCGPLATSLGSLKLMVQAVLSQKPWLHDPAVVELPWRDELYMPQPADGSKLTFGIFPTDGFTNPQPPIRRALEMVQEVIIAMGHEVVEWQPPSHQEATQLALEVFTADAGIDIWHHIGLSGEPLAKSIAQFYGKEPGTPKTVDKMWDFNLRLRQYQKKYTDYWTSTATMTKSGRPVDAILTPVTPMPAYRFDGSVPIGYTPWVNALDYTSAVFPVTKVDKNIDTFDDKYQPLNEADKKVWEEYDPELAHGTPVGLQLVGRRLQEEKILGLVELISTSLATKEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDR0</accession>
    <name>A0A0D1YDR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF300-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233397.1">
        <property type="nucleotide sequence ID" value="XM_016382694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDR0"/>
    <dbReference type="STRING" id="91928.A0A0D1YDR0"/>
    <dbReference type="GeneID" id="27335451"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08368"/>
    <dbReference type="HOGENOM" id="CLU_012923_5_0_1"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45004" checksum="202A79CA1A219D5E" modified="2015-04-29" version="1">MGLFGHDNSNHTCDTPKSFVADAPEPLVGSVTFHQLNMAISGGCVAFSTLSILILIFRHATHFSRPNEQTKILKICTLIPVYSIGSWISIAKPNSYIYITPWLEFYQGIALGSFFLLLCEYVSPSAASRDVFFAALKVTEKKRRGQDSGTGVDGLEWYRKKWFAVFQYPVIALLVAIATDVTQAANLYCLTSHNAHFAHLWLKIAIYASITMAVVAVVTFYVQLKTDLKQHKPLAKFLAFKPIIGLTFLQSILFTILRSTNVLKETSKLTWADVNFGIQTMIICVEMVPFSIFFHYAYDVGAYDLSKPRPLPLAYMGARPSPDSDSETTYAPQHMQTNSHSHSHSGEGYYGGPLGVWAWITVFNPMDILRAIVFGFSMKAESRKRRRMGNMSGQEDARMPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDR6</accession>
    <name>A0A0D1YDR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233407.1">
        <property type="nucleotide sequence ID" value="XM_016382704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDR6"/>
    <dbReference type="STRING" id="91928.A0A0D1YDR6"/>
    <dbReference type="GeneID" id="27335461"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08378"/>
    <dbReference type="HOGENOM" id="CLU_025711_4_1_1"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="212" mass="22790" checksum="FA9876960617D6FE" modified="2015-04-29" version="1">MNPQIFLIGATGRTGRLVLEEAMTRDVHVVIGDPCNAGDIEKALRSTMPNVPVVIISTLGQTRTSGNPWAAPTSPARFMDTSAKAVLAAATKVVEEGSVQIDKFVIMSMFGIADSFKNLNVLVRWTMRHSNMVQTIEDQTLVDKTVRRGHLPFVLVRPALLTDGDAAPAKVYHSSAEGVGFMPKVSAKTVAKFLMDAAARGDWDGTAPVITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YH86</accession>
    <name>A0A0D1YH86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234532.1">
        <property type="nucleotide sequence ID" value="XM_016381430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YH86"/>
    <dbReference type="STRING" id="91928.A0A0D1YH86"/>
    <dbReference type="GeneID" id="27334181"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07098"/>
    <dbReference type="HOGENOM" id="CLU_412791_0_0_1"/>
    <dbReference type="OrthoDB" id="4120877at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002236961" evidence="2">
        <location>
            <begin position="23"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="723" mass="74151" checksum="D886FAD6A84D78E8" modified="2015-04-29" version="1">MASFYFTLAVVIVATLLHASHGYVDFGATTLPFNGPILVPTPRPNQLPIDHDFRFEILPSMITAVAPSITIAPNGTREIVYSLYYHQYFSKTRQGRGLFRRGVFANDPPISTCTPCGGAVSSSGPSGTTSSSISCTTHAYLGVFRSPDPQAPSSVCLNSNYTGVFEPGTTSTTGLPCCFTIPASCLANGTSSTSFTATSGVFRPTSTFTSSLYANATTPASTSSRFSLAFESSTFVSLSSSSYSGGPILNSGSRSTTARTTVTVISGTTVVVSTSAVSSMSLTPTTPDSRSSSPSTSNMPYVSSSGSLSTSSPTSSSVPPISSLLSTSLSTISTSSVYSIIVISSTTITLSNEGAATSSSGTTTSQSTLTIITATPAPIITTTLSSSASYITTVVSNTIDGCGTASGSGIVAGTGTIFTEGISIVTSGTASGSASSVVGCGYIIATTGTFLGSAVITGCGYGSGTGTLTGTGTIWPAQGMGMMSIVSSGTISGSGSFRGCGTLTGSGVFTATEGYTTTILAPVITSSVASSTRPTKTVSVFVSYCAGDSNNQPGGGGDIIINIFGNNNTLVSSPGRVSSDGSDIVNISIFGSSSDNALCNVCPNSAGICCPPGVTCDDDDGKCPLYAVERAGNTINGYLIPQVMNSSAPVDGQRRHMARVRVKSREEKERETEMDSKGARERAKKMGQQQRRRHKHGNEHGHGHGHGHGHVEDWEKKMKRKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJA7</accession>
    <name>A0A0D1YJA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235217.1">
        <property type="nucleotide sequence ID" value="XM_016382115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJA7"/>
    <dbReference type="GeneID" id="27334871"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07788"/>
    <dbReference type="HOGENOM" id="CLU_186262_0_0_1"/>
    <dbReference type="OrthoDB" id="5279375at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9016" checksum="F9B297F3C1A5307B" modified="2015-04-29" version="1">MSDYKPTEHDGLRKDGQPDQRVQQDSFAHGKVDPHEAGKKGGQSSGGSGGNSGSGTGGGSENPQGASNLGGDGLRKDGQPDQRLKQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKU0</accession>
    <name>A0A0D1YKU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="10" type="ORF">PV08_05679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235847.1">
        <property type="nucleotide sequence ID" value="XM_016380020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKU0"/>
    <dbReference type="STRING" id="91928.A0A0D1YKU0"/>
    <dbReference type="GeneID" id="27332762"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05679"/>
    <dbReference type="HOGENOM" id="CLU_026481_1_3_1"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="54"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW15631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="397" mass="43528" checksum="9B97FC343A9BCB42" modified="2015-04-29" version="1">MPPVICEICKDARAAVIRPKNSQKICKLCFLNVFEAEIHETIVSNNLFYRGERVAIGASGGKDSTVLASVLKTLNERYDYGLDLVLLSIDEGIKGYRDDSLETVKRNAQQYSMPLEIVGYDQLYGWTMDQVVAQVGKKGNCTYCGVFRRQALDRGAAKLDIKHVVTGHNADDVAETVMMNLLRADLPRLARATSIVTASAASEIKRSKPLKYAYEKEIVLYAHHKKLDYFSTECIYSPEAFRGTARTLIKDLEKIRPSSILDIVKSGEDMATLVPPEVSSSATCGAHADEDTNGCGSSGAVGDSMAKVEEQLAANALASESETEIRVAEDAQISQTLKSAATSTHDRKPKGRRKMVKQVMGRCEKCGYLSSQKICKACSLLEGLNKSRPRNTIEIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YL20</accession>
    <name>A0A0D1YL20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235957.1">
        <property type="nucleotide sequence ID" value="XM_016380130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YL20"/>
    <dbReference type="STRING" id="91928.A0A0D1YL20"/>
    <dbReference type="GeneID" id="27332874"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05791"/>
    <dbReference type="HOGENOM" id="CLU_069253_0_1_1"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="248" mass="27819" checksum="82D67CD7033EC4EE" modified="2015-04-29" version="1">MTNYNITITSDIVCPWCYIGHTRLSKAIAEHKKTYPDDKFHLKYLPFYLQPPPQLTANGPPPPPFPAPSRPRREMYAAKFGPERAKQIEAMMLQTAAGEGLNFKFGGMTGVSRNGHRLVRWAQNHGGEDAQNEVMLGLWRRYFEQEVDITTLETLIEVGLEAGLGTKEEIKAYLESGKDGEEVDRIAEEARLKGISGVPNYEINDTWEVSGAQEPLAFRRLFLKWKDMESKGRVGSDDAKTANGNGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YME9</accession>
    <name>A0A0D1YME9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major histocompatibility complex, class I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236422.1">
        <property type="nucleotide sequence ID" value="XM_016380595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YME9"/>
    <dbReference type="STRING" id="91928.A0A0D1YME9"/>
    <dbReference type="GeneID" id="27333340"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06257"/>
    <dbReference type="HOGENOM" id="CLU_015114_0_0_1"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002247097" description="Major histocompatibility complex, class I" evidence="7">
        <location>
            <begin position="30"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="45464" checksum="10313370ABC3DA15" modified="2015-04-29" version="1">MASSFFRPPSMLRYSLYALFLGLTASVCAEALLGKDIGQLSLDEIEENLQKCAFVQNLAEHKIRTSPSQKSWTSQLFAVLFPSSSPAINSLLATAYISGPPNFLLALCPPNIDPSSLSVMVAFAVGGLLGDTLFHLLPEIFLGEDHPDRVKFVMLEPNRNLLLGVGIIVGLVTFMAMDKALRIATGGDGGHSHGDSHEHSSSSAASSNGSASTSGSSSTPSKSNGELRKRNDKSPKGEKETTPKPQQQQTQADPINPSVKLAGLLNLIADFTHNITDGLALSSSFYASPALGATTTMAVFFHEIPHEVGDFALLIQSGFSKRKAMGAQFVTAVGAFLGTCIGIFVQEYGGNSASAAADLAAGAAPKGIWGTSLQWGDMLLPFTAGTFLYVGTVAVIPELLDTGSDKGAELKKTALQFGAMFVGAAIMLGISWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMT7</accession>
    <name>A0A0D1YMT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_06412</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236577.1">
        <property type="nucleotide sequence ID" value="XM_016380750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMT7"/>
    <dbReference type="STRING" id="91928.A0A0D1YMT7"/>
    <dbReference type="GeneID" id="27333495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06412"/>
    <dbReference type="HOGENOM" id="CLU_024140_0_0_1"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF14">
        <property type="entry name" value="C2H2 TYPE ZINC FINGER DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW16361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="727" mass="80394" checksum="A8682967CDD7503E" modified="2015-04-29" version="1">MSERRFFCKQDGCSAVFTKGEHLARHERGHLGLKPFICDICTRRFGRQDSLLRHIRTHRTQTTENARFGEQDQRFGTATSLLSSSLAGTDPSTGFGLAQESMQLCQTHPISSPDRVHNSTRASNATAAADTAASNDAGRNALNYRDDFDWNFNDDDLFKILLATPTAASTSGFSRPQSSLGVLQGSAQANPDSDWLQGSAEAGRKAVQAMNRVIQSLPESLVVLESENAASIFFEDCLDLFFRHHLDVVPIIHRPTFNPRECNTTSLLHILSLGSCFLPGPTYEADSLYLISHAVMANAWEQLLTCRGPHDGNDGVQLVLSCSLGATYALVCRNSRIRKMSHSARGLGSVWARDCGLFSIDSYRGIVVPSLTAPNAEKLAAWQKWAAGETQLRGLLWQYVIDGLSSQFYHHPTLLRHEANPLSLPTSSAAFNAASPDAWIKEMSDCNRHSQLTVREYVRALFRGDVDTIRRPISKLGIRVVLECLQSLILREADGGEDTIGAISKSEIFAALLNLKYHHFDGSDSGVELLLRWHSVCLSMSADVRRLCEEVGPSQLIAELFHLPPKELEKGRNLFDLRAWVHATDARRAILHALEIRELAQRLSFGEAYSIHTPFTMFSAATVVAAFLAAESRSLHVPVQIDWAVLYEDLSKPVHSSTTLDIRSIETINFLAGTSARACGITTLRKLSSEMNMFHSQVQAMAGTWGITRAAQEVIEQWAQIFRGCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMY4</accession>
    <name>A0A0D1YMY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236622.1">
        <property type="nucleotide sequence ID" value="XM_016380795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMY4"/>
    <dbReference type="STRING" id="91928.A0A0D1YMY4"/>
    <dbReference type="GeneID" id="27333541"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06458"/>
    <dbReference type="HOGENOM" id="CLU_025206_0_0_1"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF23">
        <property type="entry name" value="PROTEIN ZER-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="209"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="677" mass="76305" checksum="A2F6B2DB913E82A4" modified="2015-04-29" version="1">MAMAPSALLRRIQIRRRPDDHVAPQMYEKETELTHSPQLLLLPPEDMNSQRKFSYASVKEEQGEGVPQSFESSLSTQDLEEVEWIAWPCSHWCRTKGLCSYHFGGTHDDFVRTRLEGYARSNPRKLEKILDELDKRRAAQKLFNLPDAKEITQFHPCPASFSLEVWREKVRDAVGTRDFTLDSFDETAIIDDDETLSQTSSSRPASYLESMPVEILEMILSRVTVDHTADPYARPHVDLASCSLVCRKLYAAAVRVMYRHVSIPQSRAFSKLMRSLNNDKSLGELVHWLDFSHYSNMGFGKARSARNQTPFLKPETLLACLDMIPNLQAFLVHEHVDDELNADIFRKLFSMPLLQALDLCACSSRPFADAFTSVVTQASLPSDLPSLKRLSLHECTTLQEEVFEAILPRLSNLTHLDVAHTLINDTALLSIPPTAKITHLNIERCTHLTGSAVVEFLTTHPAVKDSIVYLNLAADASRHRLLTASDLTLLLPALPSTLRSLNINGARINSSHLSALRTLACHVEELGIRGAQLSLASEIKPLLKPAHTIRYMDLADIQSVTQMSLNYSPSSLTDTDTLPLEVIELGQDVLGEIKRRNAHVKKPDWVVKELGRRGWFVRQRVTPNDGTDEQGKAQCQVEADDGSRSWKMGARWWGLRKIPVVEQDVGGMYGYFMFKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YT34</accession>
    <name>A0A0D1YT34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_02739</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238667.1">
        <property type="nucleotide sequence ID" value="XM_016377097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YT34"/>
    <dbReference type="STRING" id="91928.A0A0D1YT34"/>
    <dbReference type="GeneID" id="27329822"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02739"/>
    <dbReference type="HOGENOM" id="CLU_012583_0_0_1"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.30:FF:000001">
        <property type="entry name" value="Probable kinetochore protein ndc80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057091">
        <property type="entry name" value="NDC80_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24487">
        <property type="entry name" value="NDC80_loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="14">
        <location>
            <begin position="122"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Kinetochore protein NDC80 loop region" evidence="15">
        <location>
            <begin position="464"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="47"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="339"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="591"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW18451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="737" mass="84087" checksum="F9754B8C9C1666A2" modified="2015-04-29" version="1">MSQPPGLFSVRRPRETLGHIQNFSGIPQPASAVKRVSSSNELRNAPFTASHARSTSINQSVQRPAQPNFHRSSSGGNLADMGMSTARRSVSSNMFGSANTGRQSLAPNQLFGSQTPASQSIQRRSSIFSRPSGHGPVAHQSFFSQPPAPGIAPKDPRPLRDSSYRARLSQELLDYLTQNNFELEMKHSLTQNSVKSPTQKDFTFMFQWLYRRIDPGYKFQKSIDTEVPPIMKQLRYPYERDITKSHLVAVGGQNWPRFLGLLHWMMQLAQMLDNFTRGAYDDACAEAGVDIASDRIVFRFLFGAYQDWLQMGPEDDEESEEAALQPHIQAMTDEFERINSKHAEELRLYEAEHEALKAQVEEFERNAPDVAKLDKHFKILEDDKKKFEEYNANVQAKIEKYDARIKILEAEIQRTEADLQVVEQERQSLQQSVDRQGLNIQDIDRMNTERERLTKSHEDALVMLDEVNKKVLEKEAETSRKLEDLEVVVKRYNSLGYQMSLIPSTAVNAKGVDFELSLNISDNFSTSTSRRRGSPDTDRLLADNNVGYSPVHLLNLDLRGAVRNAFIALRKEINERRKAAADADLNARDFLDNISEALHEKNTEIDNLNYRVNEASRMYASLKESQTTTHTQQTSAIEKLEKELARMREGLERGVVELEQREIEVGVAWESMREEAARVREELHSGIERCLEDVIRFKVRVQKGLEEFEGWVGEEVEVELLGDEMDGMGLEDKRDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YT70</accession>
    <name>A0A0D1YT70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238697.1">
        <property type="nucleotide sequence ID" value="XM_016377127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YT70"/>
    <dbReference type="STRING" id="91928.A0A0D1YT70"/>
    <dbReference type="GeneID" id="27329852"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02769"/>
    <dbReference type="HOGENOM" id="CLU_007003_4_1_1"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="819" mass="91808" checksum="41E202C3D6B4093E" modified="2015-04-29" version="1">MPPELEPKPKSKHRKSTCAGCRRRKSKCDGKTPKCTTCIAYKDDCHYDKPPSLAYVRSLEEEIQELKLQLRQAKTQAWLSRVGDDSGAAHSHKRRADTFQASAQDEKKPVGTSPVSEAAGSQSSSNFAYRNRQVKWETDISIDDCGSVAFHNSTSPIYQPPSTQPNRSPIPASHPHPQVAGSPQEDQRVRRDLILNANHQKQIEPFAIANGAAKANVPKEISQEMLKYHWCWQHPLFLIVYRPAFTRGMAMVDLNTPEAQDPPYFSETLLKVIHAHCARFLNHDVYQNQYHDVMSRQSSNGGPMSAANFMQRMTDEARFGLGMDILKKPTIATIQALLQQSAREVMFGNASQSWTFAGIAFRMALDMGIHLPSDRLQSFVKSLTAEDIEVRKRLFWSCYTWDKILSLYLGRMPGFTPNTEEVPVNFMDDYSDNELWAPYYGETPRPDVPNAPNYQPCPGYVVSCFRQLCRLCVILNDLMHNIYSPEAAARREMEEEERSTEAKAANEAVFVRISRDLRDWLISLPSHLRINPDQMPSLAPPVHIMSLNLLYHTTVILLHRPVILGARDINAPGTSRSYQMCIQATAAIHDLIMLQANTFGLSHVSYLNAYSAYIAATIAVLRFEREYQPGEDQATAAQKNGLGFLLDVLQKTANAMPALERSNAIIRKRMKAVLDRQKAARTNYSNGSTPPKFTIPTPTSHQMDLAQPTAFQALSNPALAHATFSNPDAAGSFITPMPWQSGIRSSIYSEQAQVLDDFLPAFPGQQFPVGSEHSFGSNEVDSHARTALLGYNLDPHPRLNSGDIDWTFVDSFESHQGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YU81</accession>
    <name>A0A0D1YU81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239037.1">
        <property type="nucleotide sequence ID" value="XM_016377467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YU81"/>
    <dbReference type="STRING" id="91928.A0A0D1YU81"/>
    <dbReference type="GeneID" id="27330193"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03110"/>
    <dbReference type="HOGENOM" id="CLU_130032_0_0_1"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW18821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="135" mass="15311" checksum="71B7BD9FCDEB080B" modified="2015-04-29" version="1">MLSRRVLSKEEESESTDAEVTKEDQDKINTFSRLHNRSKVLEEELATKQKDKEDLEELSTELELADEDELVPYKIGDSFMHLPLSEAQDLLASATTEIEGEVSTLEEELGTIKDEISQLKAHLYARFGRGINLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZ39</accession>
    <name>A0A0D1YZ39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240732.1">
        <property type="nucleotide sequence ID" value="XM_016375456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZ39"/>
    <dbReference type="GeneID" id="27328174"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01091"/>
    <dbReference type="HOGENOM" id="CLU_1245377_0_0_1"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="222" mass="24326" checksum="FD849D5F655A4060" modified="2015-04-29" version="1">MRRRESTVSIPGGKQERLVETEYALYQALTPEEATGDKDSSSYDAFFSRFAGLPKTTRISEWDRWPLQTRGEREAWLQDRLASVTTPMNHGTTETTTVAPGLAGSSKTQPPSSARSPFDVDGSGVSETAGDVLQERQGHLTTLENSTGTDSWTWTGDLEFGPSPTAPTPQPFPTAPVVSPKKRKEPYTNSVTLGNSRYQASHAQQHGEAETGLDGGKWQKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZY1</accession>
    <name>A0A0D1YZY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADPH-dependent 1-acyldihydroxyacetone phosphate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241092.1">
        <property type="nucleotide sequence ID" value="XM_016375816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZY1"/>
    <dbReference type="STRING" id="91928.A0A0D1YZY1"/>
    <dbReference type="GeneID" id="27328538"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01455"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32622" checksum="5F7054A8241960A8" modified="2015-04-29" version="1">MASNTADSRKTVLITGCSQDSIGEQLAREFHRRGFHVIATARSLSRLTRLTSLGIDTRELDLLSTESIHAFSLGVTKLDILINNAGDKHLMPFADTAPKDFRYMFEINVFPHFEITQLLLPHLIHSKGIIVNHTSQSAHGFKSPASAYASAKAALATLTDCMRLELEPFGVRVVELVTGMAQGNMTKFETTYTLPRGSIYEPIREPLETNMKAEAARPMVMDGERYARRVVSDLLDGWFGTPKWIWRGAFATTMYWVLVANTLWKGCTDGLFRAALGFGGLKRNLNEAKQHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZCE0</accession>
    <name>A0A0D1ZCE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230918.1">
        <property type="nucleotide sequence ID" value="XM_016385974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZCE0"/>
    <dbReference type="GeneID" id="27338749"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11666"/>
    <dbReference type="HOGENOM" id="CLU_2904202_0_0_1"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="62" mass="6937" checksum="2B58908CFD3C40CC" modified="2015-04-29" version="1">MLEGTPRNEQGRVGSGGIKWKIINAVLEFAEASGRFKLLRFAPPEVLLHVWFPDKWGVQGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZD21</accession>
    <name>A0A0D1ZD21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231113.1">
        <property type="nucleotide sequence ID" value="XM_016384511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZD21"/>
    <dbReference type="STRING" id="91928.A0A0D1ZD21"/>
    <dbReference type="GeneID" id="27337279"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10196"/>
    <dbReference type="HOGENOM" id="CLU_011409_5_0_1"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="658"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW10897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="775" mass="86030" checksum="BBEA312EBE1443C8" modified="2015-04-29" version="1">MHPEFTSKGHSPGDRREPHMEPAAKRDAAATVKKGRKSMPKVRSGCLTCKSRRVKCDESKPECQRCLRAQRKCEGYKPHVDKTGNSGITTYSIPFKIPGSQSDRQLLHYYCCQASWNLSTYSNTTLWTELILQRSFHEPVIRNALIALGSLHKDYLCGDLVVSEHRLNAHGSSQISPPVKTMSMIGKCHRQLRAYLSRDGASPETALICSLIFYTFESLLGDSAKAIWHLDRGLTLLKQCQTDRTCETGDGLMESLTTMFNHLDIQASAFDDRRRLLVTLVSDAEVHGELDLVPDRFRDVAHAESILTKLQNWTLHHIIENLEHKGKSSDEMPLDILRERIMLGLQFERYGTALANLSASINGDTSSCLSAIPEVPLHSEQACPRTETDTILLCKIHFHCYRYLIRENLPSPLASDEEVISSPSTSSRSSSQSDTSPTEDLDVALDSLKSLLSLSLEYSSNGRAPPTGGANNSTERIYTLSTHLIAMLYFLTLKATKPETLSTALELFSHPRIRNTRDGLWDAHTAFFVVQNLLKLRDNGAHNNTSKLVHKEISDHADIKEMMTFQELNTGKEVPMMQSRGVTITLDQNTSPPSVMDARTQLHPSRRDEECKENLDANRDNTLLLLPPYFPFVTPTTDINATNTMITQPASGSGSEPTFSHLSSTPASSTISRSKPTCTTTASPSEDTDSTLTTLHQMWPPVSNCSSSHIPQLQTTASEFYQSASSPLAPLRQQTFHPPRLEDVGLGMIDADGGVNEAARIVWGRVQELDLSLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZD95</accession>
    <name>A0A0D1ZD95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231163.1">
        <property type="nucleotide sequence ID" value="XM_016384561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZD95"/>
    <dbReference type="STRING" id="91928.A0A0D1ZD95"/>
    <dbReference type="GeneID" id="27337329"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10246"/>
    <dbReference type="HOGENOM" id="CLU_166246_2_0_1"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW10947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="78" mass="8840" checksum="04646F9786F65A24" modified="2015-04-29" version="1">MPKAVKGALLQCDPPQMAMVRKIDRESNNAYIIEEIDDHTCLVKETKVEEIKARVKELMDAAMGMDEDDNDDKDSDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZDI5</accession>
    <name>A0A0D1ZDI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231228.1">
        <property type="nucleotide sequence ID" value="XM_016384626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZDI5"/>
    <dbReference type="GeneID" id="27337394"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10311"/>
    <dbReference type="HOGENOM" id="CLU_040560_0_0_1"/>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="378" mass="41421" checksum="A73EC0508E2DF53F" modified="2015-04-29" version="1">MTLGNRCFQNDLEPSRRADARQELYDCLTRINAYNPPVQTCSTGWSFSGLYHGPTSVAYLFLRLSQHYPDLTFKGQSLLDWAEAYLTLGASQSKSVDSSHCGVANETLAQVAIRAVIDRDPSLVQQLCSYQTMINDAGGSDEWLYGRAGYLYLLRLAGSVFTKSSSSAAKMIHETIQKTVQRILASGHPWTWHGKAYVGAAHGSFGILCQVVLSGPSAADSVEQILSQLLETQYPSGNFPSSLPRSSDKLVQFCHGGPGVVLSLRSLRPHLPRLREKIDSAIAAAQRDTWKRGVLVKDPCLCHGIAGNALALDDADEFQHFVTYMSSDSLEAQGWLEEAGRNDSFVGLYTGEAGRAWTWAVAEKFDQLIGKCIGFNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZDL4</accession>
    <name>A0A0D1ZDL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231283.1">
        <property type="nucleotide sequence ID" value="XM_016384681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZDL4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZDL4"/>
    <dbReference type="GeneID" id="27337449"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10366"/>
    <dbReference type="HOGENOM" id="CLU_027656_0_0_1"/>
    <dbReference type="OrthoDB" id="4160688at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="613" mass="67696" checksum="6ABD384275ACCB33" modified="2015-04-29" version="1">MPRPPKPPMTLKEAKKAYKKEGIGIQYTASQMARADRFDEREAKRKKELEREKQRVDNKRKRDQKEARERAVKQKMLEEGRITVEDTWGKVTASQPRLNKFFGQNAVAASKKNTKDVTTDHKEKNRNMQGDDQPAQGETKTTGHTPGADTTIVRNVLQVKSPSGISCPSVLEKENSSSNTSLSKSHLCNTASEESNSLRHVPNPSSALSELKHAQLNVPSAGSRKLVYDTKPWKVYNPTRTASETEARKPEIRTYTPNEVHDNDGPSVETYFGSKNIEYDPNLHSSVNATALEYQGSDENLSRTTNEVDEEEDFSDGIDDETLLELYDDQYQQATTPRGASADLCSPTSTVTLSSPSCGPEVGQPCTDKEEKPKVLPKSQSNLSDSFTSCFNEIDEDDLIALAEEVEAEISTPLASADKTAENGCFPQVPKHSLGLEKQMSHGTPSPPQLARPEPPLPPRSQPTETKPSSSKPGVVTPLENDSRHKTNTPNPKREPLQGKGIMAPPPAPAHPRIREGKKNSRDDNNNTTTSSVSFQRPESVARTAVSKQRTKRVLPWNKPSKQHYYTNHDNPSDDFDLLGPSTQALMVELAEQAEAQISSCSEGMSGKGSRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZF37</accession>
    <name>A0A0D1ZF37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231788.1">
        <property type="nucleotide sequence ID" value="XM_016385186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZF37"/>
    <dbReference type="STRING" id="91928.A0A0D1ZF37"/>
    <dbReference type="GeneID" id="27337956"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10873"/>
    <dbReference type="HOGENOM" id="CLU_1807281_0_0_1"/>
    <dbReference type="OrthoDB" id="5152093at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252746" description="GPI anchored serine-threonine rich protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="13824" checksum="A19E50900FC924BA" modified="2015-04-29" version="1">MRSFFYLLTALPLLASAWSQHTLLTRATGNATSCESTDKPCGAYCIPSDYTCCPDLEGGCAATSTCQLGDNDVYGCCPDGDTCSGDGGAEFLTTSTSTADASTATKTTSSDSGAQALSMNHGLNLALVAAGVAVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZG92</accession>
    <name>A0A0D1ZG92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232203.1">
        <property type="nucleotide sequence ID" value="XM_016383580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZG92"/>
    <dbReference type="STRING" id="91928.A0A0D1ZG92"/>
    <dbReference type="GeneID" id="27336344"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09261"/>
    <dbReference type="HOGENOM" id="CLU_004392_0_0_1"/>
    <dbReference type="OrthoDB" id="74412at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1122" mass="121870" checksum="3CF4175311A8EDDE" modified="2015-04-29" version="1">MSLNGLDGAAVAEAYQAVLADAGGWFLLKYANRDTVELLQKGTGGVQEVRGAIEGYEEKSPLYGMVQYRRKKVILKYVPEGTSRLLQVRLTVQFQSILETFTPHDTVFSFTVASELTDSTLGLSTMLLPSAGSLTSSTSSLRRRRLDEITEDAEEGNSEPEEKVVHPTQVEQEPITPKYGRHELDELPASAVLAKALLAKRKETAASASTGHNEDSIRLDIPVPPPAAAVSHKGQSSLNPTTIEKNLAITPESTPPTTSGGEPARAPDFETASNILLDATNRDLTEPATPRPPQSHHLSPAESDSISQWSSNVASYAGVKPKKKKLGPRPHVEATNRPKTSGTADSNLGVRPVANLPHSIRVNNRSLLTLSGRPGSQRSTRSVPGRFANSSHSFSGPPPLPSPSHIQSLYNPIENRPAASRPASVTTEASAATPEKLRMMKALQLRKRNMLLAQRSTLTSATSHAPTPSETSLSTISSCSDLSTVTSQEQHSSVDEESKLAESSSTTSPTFMTNTSEEPSTKASSISEQDDILNKRRSLSSATSSSITPKAPARELPAQAHEKVATSRPSSSQGLGIPVSFSQQSDICKESTTSDIRQASGVNISPPTTAAPEAPLPVQRHAPKPLQLARGDTSVSDESSDDELLMDDIDNATVHEAKPVSVARSPVVTPIISTKGSSDRLREIVTKASLSSQPPKSSRGSTPEGRRTASRSGSVRSVSTALPQWPPVQAEPMPAPLTKKPTLGTGISKRIKALEVLTAKDTNASQPPTPTRETSVGKSAFSSFMKRSSLVGNHMKPNASTERSPPKKTPTIVSLYDPVKQTNDTKESRRPSIDSYAPFQKADTISVTAKIVRDPNSKHPPMSPSSTFNTPLNLFRSPLIVEHEKHDNLEREDSFTSRQSNTKSPTRSERGRFSFSSHRSTSQTNLPRSESNHSKISYASTHKKHGTRSNSDAASFTEEKSKSSRTSRLMKRVSTLTSSRSKIQSGSKEQTHPNTIQEQHDEDTKEHSVRESLMHIVDIGDVNVQFPESLLWKRRFMRIDDQGYLIFSPPMNDASTKSVSRKYHLSDFNRPTLPDLEREEIAWSIILDLKDGSCVQCACESRQSQQGVLQSEFQPSFLVIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZGB9</accession>
    <name>A0A0D1ZGB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232218.1">
        <property type="nucleotide sequence ID" value="XM_016383595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZGB9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZGB9"/>
    <dbReference type="GeneID" id="27336359"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09276"/>
    <dbReference type="HOGENOM" id="CLU_067861_0_0_1"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000254">
        <property type="entry name" value="Ran-specific GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="102"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="244" mass="26780" checksum="CA850FB40E0E6453" modified="2015-04-29" version="1">MSDAAEVKPTPSADQTASSEPRLAEDETKLVQNPLGDPSTEAPAGEDKSSSVTETAANAASNAASTASAAASGVKDSVFSMFGGGAKKERKDKAEEEEADVEFEPVVRLTEKIDTKTNEESEEQTFKMRAKLFKFDRDSREWKERGTGDVRLLKHKENGKTRLVMRRDKTLKVCANHYVTPDMKLSPNVGSDRSWVWNVAADVSEGEPEAQTLAIRFGNSENANLFKEAFIKAQQDNEALFQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZK64</accession>
    <name>A0A0D1ZK64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_08409</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233438.1">
        <property type="nucleotide sequence ID" value="XM_016382735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZK64"/>
    <dbReference type="STRING" id="91928.A0A0D1ZK64"/>
    <dbReference type="GeneID" id="27335492"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08409"/>
    <dbReference type="HOGENOM" id="CLU_015739_0_0_1"/>
    <dbReference type="OrthoDB" id="3341590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000002">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000018">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015328">
        <property type="entry name" value="DUF1965"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09248">
        <property type="entry name" value="DUF1965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237827" description="Amine oxidase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="12">
        <location>
            <begin position="84"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1965" evidence="13">
        <location>
            <begin position="258"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="11">
        <location>
            <begin position="335"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW13222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="811" mass="90181" checksum="D5B5062627A90845" modified="2015-04-29" version="1">MRISSPALLAVSGLAAVTSASPFFMKNFATGKKPISMPAQYKHAVLQNNNQNTTGPCYASSTLSTTKSPLDNIFSALSEVEAASVTKFLHEQSDLNLTANVNATSWDNVIVLVELLQPNKSDALPYLNGEGPKPHRYSKATIQFQATLEPYIQEFMVGPLPVSNETTLQPLNYPFNKGVGIQKIHNADPDEYSQFLVNISTSIEDILINMFGGTFTNSPDDVVTIGPSDPLWIDDETGAVTTWNEYSPAPTGLYGTGSLLRSGLAVRTDLTGRDPSKWSVLGWYYIGQFFKTTDDLKAAFNNGTVDYIKPQPDGDWGVTAPSGPVLPQDEIPPPVSVQPAGPRYGVDTEEEYIEWMDYSFFISFTRDTGMRLFDIKYKGERIVYELGMQEAVAHYAGMGPGESAQAFLDSYYGFGPNAFELVKGYDCPAHATMLNTSFYWREARRSHENSICIFEIDAGYPAARHTAVNYVYTTKNVHLVVRSVSTLGNYDYMFEYAFFHDGSIHITVRASGYIAAAFWAANADYGFHIEDTVSGSMHDHVLNYKLDLDIHGTKNSLMKLDVVPTTEVYPWADGQPRNTMKLKRSFIETEDDSKIDWAPNLSTMYAVVNKDTPNKWGEYPGYRISPATASTAHLTIVNSSDLKNSARFAEHHLYAVQQKDTEPRSAYSFNSLDTANPVVDFDKFFDGESLDQEDLVLYFNLGMHHVPDTQDLPNTVFTTAQSTVVISPQNYFLQNPIRETIQQVEINYDLESQAVTGIKKFGSEPAVCTYDMSNTVANLSDYHGGDLVVRKWPYDPSNPFFGTTEIEQIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZKR4</accession>
    <name>A0A0D1ZKR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233638.1">
        <property type="nucleotide sequence ID" value="XM_016382935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZKR4"/>
    <dbReference type="GeneID" id="27335693"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08610"/>
    <dbReference type="HOGENOM" id="CLU_178678_0_0_1"/>
    <dbReference type="OrthoDB" id="4114426at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="103" mass="11086" checksum="3F4EB10D75E6F059" modified="2015-04-29" version="1">MAEIKTRKSSDSFAAFVSSEKSTCSRQAQAKALARTSPWLTTEWVNGNVNFDSHFKDYEIESPAVALQEAVGGVVKWVMDSIITEFGSAASATHGTRGCGCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZKZ4</accession>
    <name>A0A0D1ZKZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233693.1">
        <property type="nucleotide sequence ID" value="XM_016382990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZKZ4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZKZ4"/>
    <dbReference type="GeneID" id="27335748"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08665"/>
    <dbReference type="HOGENOM" id="CLU_046738_1_1_1"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW13477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43060" checksum="C9EC0AF80B7D240F" modified="2015-04-29" version="1">MVNVFAPQIFFIVFRECLEAVIVVSVLLSFLKQTLGQPDQDQKIYKRLVKQVWWGSILGILICLIIGGIFIGVFYGLGHNIWAQSEDLWEGIFYLVASIIITAMGLPLLRINKTQEKWRVKIAQALVEQKNKHHSVGSYLSSWSRRYVMFILPLITTLREGVEAVVFVGGVSLGQPATAFPIPVITGILAGLAVGLILYRGGNVLSIQIFLIAATSVLYLIAAGMFSKSIWSLQYHVFAHKVGSDVAEAGNGPGSYDIRETIWHVNCCNPETDNGWDVFNAILGWQNTATYGSVISYIMYWVFIVFCVLCLLYEEKTGSLPLKKQLVSFSLKVPGVRTYIKRKQALSKDQAEDVIRQGQEHLRAQNALQEPDIQVVPSEPQSGLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZM29</accession>
    <name>A0A0D1ZM29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234108.1">
        <property type="nucleotide sequence ID" value="XM_016381006.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1ZM29"/>
    <dbReference type="GeneID" id="27333756"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06673"/>
    <dbReference type="HOGENOM" id="CLU_005258_0_0_1"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="2">
        <location>
            <begin position="1237"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1487" mass="165712" checksum="5B31B42415BA7286" modified="2015-04-29" version="1">MSKTNFESAIAALERTAGPPESLLAAAASTLGIDLEASIASSSEKLLPRAASDSTERTGFKEQWVLRWLLKKLASPGTVSSFSTCPQFWSLLINLTNSIPTSVCLEILVERNFYRTLSELIRHALSSDNVSPIHDTSSDAGDGSSSRPSKKRRLSPTTDITLNIKSKNKNSLWILLQAVCRCVELLVSPSAQHGNKPLQLSSLMQISVDEQAALLGSTLEVALAIIKTSPEMSEATLLSHMINVALSAWSCDSMSYGAHRDNLDHAFSSHCLAPCLHLLDVEARFGHSPLTSSKQALERLVAVHVVFSARSTFNAKDARNWRNAQDVLVYEQFEAMLKSFKRRFFAEEGAQRTNDIFNLSSLILDIAVRAIPSTDFRRWQAEQPWVEALFICLAHLTWPHMPRISSTGVVPNPMSGSADHERSLAALEELVDVARIHRLRISLPVLRYFIAAILAFGHDTTPWAVLLDTVRLDVNVLIPGTGLSKSEEILNSLLGKVVGSEVSTGIYQSLRDDLIIPLLRGFARSRDLDGYLVIWQQGLTDAMRARYTSKSQPDHIPAVLVWDDEDLFDEFGKLSLVHAPKSMPNHLLKELNESFEEITQNIGLTADTLAKVAIFSAMLENSQDLTMEWNPESDQLSILYKHLMSALSRKSDYLAQRWRLWKLVQLLLSTSGKGTLAEMGKQLLDPATQFVSLGEIATYQLRDLTRKRASKYLEALECFSTTLELSARSPTYSHHFETEMHHFRSLVDASAQSQSGDGSDTWSGRAFDCDSSRKLVYACAGKLLQKSAIIRDYPLVFGKLSELCLDILAKTKNPEEHDAIQANLRTLIGILLRTDEMHTATQLHQSILQRAVDEPNPNSGSFEIRKMLLEDVSEALMRRSQLKKLGSVLRQRLLAISGPIDIEAVSQDLALMLQIDDSISESLFDSRDWRAWINLSQETCRVGTAEPSMPLLAAMQMLDRILKLIWTRAISTFQTPALSEMIDWTRDTVKLSENEKHATTHLLGLQALVGQICSSKSLLGDIIAESKVRKLREQFFSVLERSLQQSPANNVILKNTIMIQLLIRAVSVMRDATSDESTRQVVSLLRDRSVVRSSSQKHPQSEGLEIYAEWEYMKLSPEQHPICTAEEILAQVQDLASFASKISRDHCESEQLALLCTRAHVIASRIKPTGMGDALQLLRKSSSQLTLDTPRCILTSAIISHANIDLMSCTPRLADELTYIVTLNASKCHDMTGLFLALENCKIVLHGYPLLINQSALDKLLASICMLGAYSLVPFPGTADSARDNQPGPVDLFDQCCAIIGIVLSRYRRRISDRYHLLLPVLQMLLRCLFWPGTETVRNRQHHGPAQNLNAFKETLPVWLHGSADSLPPSSAEKLSRLFSTICNPSVSAARSAKKGGHNELNDETMRAKHLAGQHMQYVVVGYTRCALDGQIMPTVKERLMPGMYAVLDSMDRELLRAMNAGMDPSSRAIFKNLYDDWTRFGKWDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZML7</accession>
    <name>A0A0D1ZML7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234253.1">
        <property type="nucleotide sequence ID" value="XM_016381151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZML7"/>
    <dbReference type="GeneID" id="27333901"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06818"/>
    <dbReference type="HOGENOM" id="CLU_148173_0_0_1"/>
    <dbReference type="OrthoDB" id="3872446at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="102" mass="11101" checksum="5E56C21EF1D6C486" modified="2015-04-29" version="1">MAEPDEVEEDLFADLYDGDENAAAAGTAPVPSQPLATDTPMKQNDVPGYGEEPETAYDPAAFDADNSAFEEPQSSFKQDPQEQEKAEPSQEQKYNVTLKEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPE2</accession>
    <name>A0A0D1ZPE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
            <ecNumber evidence="3 11">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_07466</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234898.1">
        <property type="nucleotide sequence ID" value="XM_016381796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPE2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZPE2"/>
    <dbReference type="GeneID" id="27334549"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07466"/>
    <dbReference type="HOGENOM" id="CLU_036762_1_1_1"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="95"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW14682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="346" mass="38725" checksum="854553F5AEFD4340" modified="2015-04-29" version="1">MKLDQKGKVLAEYIWIDGTNGLRNKTKTLSKAPKSVDDLPEWNFDGSSTGQAPGDNSDVYIRPVAMFPDPIRLGDNILVMCETWDPDGTPNKFNYRHDAARLMEANAKHKVWFGLEQEYTLLGPDGWPYGWPKGGFPGPQGPYYCGVGTGRVYCRDIVEAHHKACMYAGIEISGTNAEVMPAQWEYQVGPCEGINLGDQLWVSRWLLHRIAEEFGAVVSFQPKPIPGDWNGAGLHTNVSSKEMREEGGMKYIEEAMKKLEKRHVEHIKVYGEGNELRMTGAHETSSIDKFTWGVANRGSSVRIPRACAKEGKGYFEDRRPASNADPYQITGIIVETMYGSLPEEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPQ9</accession>
    <name>A0A0D1ZPQ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235018.1">
        <property type="nucleotide sequence ID" value="XM_016381916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPQ9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZPQ9"/>
    <dbReference type="GeneID" id="27334670"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07587"/>
    <dbReference type="HOGENOM" id="CLU_001851_0_0_1"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF4">
        <property type="entry name" value="VON WILLEBRAND DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G01160)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="71"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="362"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1201" mass="133557" checksum="EBFB08326E523578" modified="2015-04-29" version="1">MSHHFRIERLPSGMHFPGPPRKLIYQPELGKKREIPPRDSQVPSEYDGFPFPKFPFANFAAHKVTSSKSPAPAWSKLDEPPTLCLPLLQVSVEVLVDGTIAHTILTQSFNNASNESIPKVQYTFPLYDGAVVTSFRCSIEGRILVGEVKPKEQARGEFEKAVKMKHAAALLEEHTPEIFETTVGNVPPSAIVKVEIAYVSELRVALRDDTKEGLDVVIPMSIAPRYGTAAGTYSTHHNFEDDGLDIVIKVKDSGTIQDIKSPTHRGRVKVRKNVVPKSTEVQSFDQLGTKSTTTQMVATFESHSSIMDEDFVLAIEMPPSHPLRSRAVLSPSNQAGHAALMVNVKPNEVFNGDFQAQNFDGEVIFVLDRSESMGWSTNKTGGYQSDTTKIGTLRQAMPLSLVSLPVKCAFNIVSFGTHSQFLWDKSKPYSEANRDYAMKYVRTVKADMGGTEMMFAIQQAVESRSTDRCTTQIIIITDGELDPEKVIDYVRKTRRELQSKIRFFALGIGDQVSHRLIESIGEFGGGYGEVINLRANRRWDVSLSRMLKAGLTPDSWTLEISLGAGFQRRSLVNYQLGERPQEKLLVPYIQAPYPSPSLHPFTYHSIFFLLDIGMQPPPAEVILRPTNAGTKPEAEHFITVEQTWTNKSTIHHLAVKAALVELEAEINREAPEESQSYIGGSNAEKLGATYSIVSKWTSFVAVDQENKDFHEIDMSKAEMIDIDIEDLESNSEDMGSDLAMIGSSDEDSSCEYAFGPGAPPRSRAKPPIHILPNTADGRKPRADRSIGSSSFPVLHRDGLSTDGSFRTSPPKRGTTVNFAKNVNSWRGVKDVFKRTLKPAKLFQRRRSKTGDNEMYDDYEAESDYEEEGGYEGGIDYQEGGGSQKGGDCEEGCEAGAEIGAYEPCRYSSEDNLEEPEASRDVSDDSITLMDAVDVQDRDGIFHLPRSLRETLQRHFCPGTSTSLVATLAQISTVPPLSNRKRRTLADTLMMIQYFKVHAAQERDLWELMMDKAEYAVRQALQLSGEDEEEEAIFASLGRITDGASKHMHFLTTIDPSEERSVGSFPPSRTIEVCPSCGTNSEVEDLVQRGKRRDGSRHQVRHQVGSEPPRANYRYATLPGSVSSHQTPQLGTPPPVTLSIRTATTAKRPRSRREPSHKPQAVSSSRTSFILPLPRQISVETRETEFPSRGPRKSEKQAKFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZUI7</accession>
    <name>A0A0D1ZUI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_06479</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236643.1">
        <property type="nucleotide sequence ID" value="XM_016380816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZUI7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZUI7"/>
    <dbReference type="GeneID" id="27333562"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06479"/>
    <dbReference type="HOGENOM" id="CLU_010104_1_1_1"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="217"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="384"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="421"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="610"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW16427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="650" mass="71431" checksum="9AB0D6F3B619BBB4" modified="2015-04-29" version="1">MFRAQQNAFDDVVAKATDENLTSENWEFILDVCDKVSASDSGAKDVVAAMIKRLAHRNANVQLYTLELANSLAQNCGVAMHRELASRSFTDALLRLANDRNTHQQVKSKILERMESWSKDFSSNTELGIMEQAYLRLKAQNPNLQPPQAPVKKQITDYDRQKEEEELQMALKLSIQDKSVPSPAAQASGSAAELSAQPASSAQQPVHQPVPSGTTAATVSRVRALFDFQPSEPGELQFRKGDVIAVLESVYKDWWKGSLRGQTGIFPLNYVEKLQDPTPEELQKEAQMEAEVFGQIKNVEKLLALLSTSTGDTNVRDNEEITELYHSTLSIRPKLIELIGKYTQKKDDFQQLNEKFIKARRDYEALLETSMAHSAQAYARPSPAAYGYGGGPPPQGYPPQRFYTPDGQPPNNAVPYGNPTPFQPPYPVASPPPHSRTPANQPPSQPPPDSNYPSYPSAPVRRQSQPEQYAAYAPPSDGRPLTQAQYPGVQPPNITQLQHQEETYSPSNYSSEDLHAQRVSPPPQTQPPQQQQPYPPPMNTSYAPAQAPSAPSQPPYDYSQQQLPPPQANVSQPPAPSHGPPSVPGVSAAPDRPLTPLAQASPYPVFPPASGTNLPNQQYQAYNQRPTSVAAVPQAPGVGAGDQGRYSYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZUN2</accession>
    <name>A0A0D1ZUN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_06511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236673.1">
        <property type="nucleotide sequence ID" value="XM_016380846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZUN2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZUN2"/>
    <dbReference type="GeneID" id="27333594"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06511"/>
    <dbReference type="HOGENOM" id="CLU_019412_0_0_1"/>
    <dbReference type="OrthoDB" id="70387at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF21">
        <property type="entry name" value="FLAVOPROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="583" mass="65869" checksum="CF2F04AA3C9F5D2C" modified="2015-04-29" version="1">MATDRKSRLKGRRVNVLVFVNCALGPQLLPYLLQNPDLNVRVVCDMPKAEYQSYTKSSVNLDQVPWFENTSRDTGRNQRSHTMMQAHRLARWADLMFVILNAQLVSAMLNGLATDLILHVLRCWDVTKRVALLPEMSEDQRRHPIWRKQLSKLEHKWEWVRVLPPAIWDYSPDMPGFTIHGPEPIFTDPEPVIVWHWDGPGEIIETIESEVQSILRSTSKANAMVPYPSPAHAASKPRLPSEIWTMILENVGDWELATALGIYTQLPMPHEWESLIPEPGSKKPPSLEFAILTQPVSQIKTYFTNTTSSQPPTTLSSIATRLIFRFSMTELLTYLALHQKDIFWTSFGLALLPHKASLIYNSPTILTWWKDCPAVIKKEYGPEALDGASRAGFVEVLDWWLDSGLKLTYTEKALESASAKGHVEVLEWWRVNSLKLAGTSRELPLKVGKSILLAAQAGRTNSIEWWENSGIPYAHEDGVARLASAHGHVGVLELWHSFKGSKMIFDNQVLVGATKNGHAGVLQWWKDVSRKTGLRVEYKTCDIEEAMEDAVGGGGESEVREWWSRNGLNLGVGTGEWMRVKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWI5</accession>
    <name>A0A0D1ZWI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_04213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237238.1">
        <property type="nucleotide sequence ID" value="XM_016378561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWI5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZWI5"/>
    <dbReference type="GeneID" id="27331296"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04213"/>
    <dbReference type="HOGENOM" id="CLU_020019_5_0_1"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="40164" checksum="5ECC721772D0A62B" modified="2015-04-29" version="1">MSSRHDDPSLHDHAGTLRPAVTPLQHRRDTHSDASATATPTPTARGYAHLTWTGTGSGTTGMVPFAGRLGGNQTFIVDRSDPANAELLRKVPDAAPNLNLREMFELGGFREGGLWKAAIVECIGTMILVFGSTYNSLSPYTPPPTPTTTSGVFGTVVFLAPLVAACINAILIAILIYCFGAISGAHLNPLITFATFFARLATFPRLVLYVAAQTLGGTLAGLLLRAAAGTRSFKVGGCFLFTTDEPTTQVSSQFVIEFMGCLLLVFMAFGVGLDPRQKEIFGPALAPILVGLSAGACALCFAFSGPGSGGAALNPARCFGVFVGSRFPGWHWINWVGPLAASILHGVVYWVVPPGSGSVDQNRAAKMVADRDEKRVEGDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZXF0</accession>
    <name>A0A0D1ZXF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA mismatch repair protein HSM3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237573.1">
        <property type="nucleotide sequence ID" value="XM_016378896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZXF0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZXF0"/>
    <dbReference type="GeneID" id="27331632"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04549"/>
    <dbReference type="HOGENOM" id="CLU_821408_0_0_1"/>
    <dbReference type="OrthoDB" id="4538483at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041335">
        <property type="entry name" value="HSM3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18795">
        <property type="entry name" value="HSM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein HSM3 N-terminal" evidence="1">
        <location>
            <begin position="54"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="339" mass="37744" checksum="FB9072BDD287C626" modified="2015-04-29" version="1">MDTISENKDVLFPQVFSHLSEVEAQPATVVLDEELLRRAERSLDASTSRDLLWRLLATGERLLQTLQQEPRPLTRLLERTVSLLPFDELKNTISAEKLQEGLTSSSISVQLLCLAYLRKAADSPSGASFVAASSPLVQCLLTTWLSSENTEVAERCLEAIEALLAVDSHTSFTVLATRESVAEVQGQGLLWRRIFTDPQVYSILFEWTSLRVSKRDVKTKKGMQLVTISQARLFDCIARLANYDWAAISTTTLPAVEAKFADGGADDQPYGGLLRYAASHMIDQRDILMEVLRQDFFMKLLGVIQQGNPQSVPPRMLEALQHEAGIDPAKVDEENGMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A2J0</accession>
    <name>A0A0D2A2J0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239378.1">
        <property type="nucleotide sequence ID" value="XM_016377808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A2J0"/>
    <dbReference type="STRING" id="91928.A0A0D2A2J0"/>
    <dbReference type="GeneID" id="27330538"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03455"/>
    <dbReference type="HOGENOM" id="CLU_014024_0_0_1"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="521"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="711"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="722"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="737" mass="81804" checksum="D0602481CC7907F7" modified="2015-04-29" version="1">MAHPSTPQPHIFQPTPIPATSGLFNSVAPNSRTVSGTNTPTGSTYLMPTSPAKSALSSKDGSKPKIVKTTGQKPACLVNASVTYCGNEQIYAFGGFDQFTDEVYNHVLRLNLKTLNWALVDNYGDIPGVRMGHSASLYQGDKLLVYGGENEHREYLSDVVILNLKDHHWTQPEVQGPIPKGRARHAAVVYEDKLFVIGGLTGEANYILDDICYLDLKTWTWSKTWSFVQRFDHSAWIWGGRLWVLGGLGADMERPSEIWWLDLKGSPALSGSGKQYSTMGRIPGSRSDPFLHPNRADRVDTYTANSGSVHIRSSRREKPTAPGAISSLKFVSGPHVPLQSSGTHFHVCSSGTLLDFVTPSSTIRHSECNLSSLELDSLRWQRLVEGPELFQPGYKWHYCTINEDGTKVWLLGSAAEDASATGQDLQLSEVLAVDLKRYGLLGTQEGNLSSEQNRILASERPTVHANSLSGGTGLGADFAAIFDQPPETSMSDFVVTANIESADDDDVSETGSQARFSLNSTSSQLLVSDNSNVSHPIYVHKMILQARWPHFKRLYASKMIEYQTSRLHIPEPYSVVRAFLYYLYTDSIAPHAEFCRDLTDVAGMLVMANLYDMPKLRLLCVNRLSREIDIEYAAVIWERAGRTEEEWLKARAARFCLMNWGRIVRTEGFRSLSRQSLMELCEVVDTEGRVVGGEELDDVCVDGFGVGGSYRHRRRSHRPSETADETEGDDEDGMDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A684</accession>
    <name>A0A0D2A684_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="5">Glu-AdT subunit A</shortName>
            <ecNumber evidence="5">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="5"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240518.1">
        <property type="nucleotide sequence ID" value="XM_016375242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A684"/>
    <dbReference type="STRING" id="91928.A0A0D2A684"/>
    <dbReference type="GeneID" id="27327960"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00877"/>
    <dbReference type="HOGENOM" id="CLU_009600_7_6_1"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="73"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="313"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="567" mass="61843" checksum="5E0027F73EAC92AB" modified="2015-04-29" version="1">MPHRIGRGYRHHQDIKLLRHVCSLLCQSLNPKDYGNPFISLSNALRDPDALLREAVKAHGAHASTEDFRFFYGIKSANHGYTVVIKDNIVTPELPTTCASNTLKGFLPTQNSTVADLLQRGGQIMLAKTNMDEFGMGSHSINSAYGEVHNGPLAGPHGGAALSVGGSSGGSALAVASNLATVGIGTDTGGSIRLPAAYMSLVGFKPSYGMISRKGVVPYANSLDTVGLVAKFVPDVWLTYDILTKPDENDPTCLSSASRTRVRYATYARDTALQGTKILPVPMNGPRFSPASPAASGRYNPRKHPILPRKTLPRRIGVPLEYNIQEMHPLVRWSWTATLSHLEKAGYEIVPISLPSTKHALSAYYILAPAEASSNLAKYDGVRYGSNRHGHVDDANGTLYSRFRGQNFGREVQRRILLGTFSLSAGAMDNYFIQAQKIRRMVQQDFDSVFRMPNPLRDGTKVNKQGVDFIVVPTAPTPPPRLKYVRTGTPLESYINDVFTVPASLAGLPAISVPGPRHPDIPWRPEVAVGMQVIGQYGDDFNVLKMANDELTNFHPGVTRVRYGKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7Q6</accession>
    <name>A0A0D2A7Q6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">PV08_01400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241038.1">
        <property type="nucleotide sequence ID" value="XM_016375762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A7Q6"/>
    <dbReference type="STRING" id="91928.A0A0D2A7Q6"/>
    <dbReference type="GeneID" id="27328483"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01400"/>
    <dbReference type="HOGENOM" id="CLU_015164_1_0_1"/>
    <dbReference type="OrthoDB" id="5319830at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW20822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="639" mass="71419" checksum="74D9818E9870C025" modified="2015-04-29" version="1">MARSDAISLLIPSQQHGSSEDLQSQIQRVVAQKGHFRHITERSLLAQDQGKASLDQSTDSENDVQIEDDESQQKRQERLWKRREEMIERLSYAQNEILCALDFVSLLISKQWTPAQGSMSPALKESVPVGTLAARVLPRKHLSSTAQRQLTSVSQGWRSESFRSASEKLADASTRLQKDAERETEYWAQVTRLTNQGWTVSRLPRDRKAIGVHFGFPQSAPQFRDRGFALLRQLDDGSVILDQQSAMRSQKTLGVYIVRDNVKTGFSLFKSRRTSNQSGHDEGDITQQIIQMRDSLFEEELFYEICREARTVANQGIHIRSHSVDVAVGSDFQLSLVFGQDLDTDIPSNVEDDLIAEFVAVSLRLLLNAAHEQNLARRSRKAAPLTLKPRHAPEYALVRPVLAHLRHRAEAVAFWTDCKVLVHPFEKAGLPVMLEVEKSTTKTFEGVSIEAPSTFLSEMMIPAKSRFKIAMTQNKAFEICLATFLGPPLFGSRYETSALDLGFVTMPLAHQETREAAVQAVCHMLTLGLVSHAENLTKRVADGLPNNEIQENAKKWEVSLPHNGELTLYDAGDPIRKIVASVRPGVIVVQTRSLRREISNHEIWSWTSEGCSKVGGANGAVDPATTFDEAIATILHINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7V2</accession>
    <name>A0A0D2A7V2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241083.1">
        <property type="nucleotide sequence ID" value="XM_016375807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A7V2"/>
    <dbReference type="STRING" id="91928.A0A0D2A7V2"/>
    <dbReference type="GeneID" id="27328528"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01445"/>
    <dbReference type="HOGENOM" id="CLU_024074_0_0_1"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21210">
        <property type="entry name" value="CH_SCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="651" mass="72773" checksum="479C651055DA674F" modified="2015-04-29" version="1">MASVTSLDQDMRKLRLDRYTPGAAKEVRAWIEDTLGERLPPGDLMDALKDGVALCKLVNLVVSPGVKYKQSNMPFVQMENISHFLRACELPPLNLPSHDRFLTVDLYDGKDPAQVLQCISAFSRAANAINPGAFPSTLGAKSKGAAMSPQGTGSSGPRSPAYTTTTAARPRGTSNATADSPSYTFNPLNKAAYSGRISPTKNTLGRGGLATGGAVSTWSSKADEGKTAPAWNIHQYGYMGGASQGNQGVAFGARRQITSPAPNVPSAAEKEKRLKEEAERKRRDAEEYERQQQAQRAAEEEQARLEEERRWAEETRRAREQEIEEQRAQERERLQEEERVRREEQRRRERAYELEREREAADQAEREARSAAERSRQRATSDARLNGQFLSQYQADQARVDAATSHKQHIIEQESTESRRIAELERQLEELKAQQHQHTQPSPPARSQVEPRQPPLPSRSNVGQTSHEDDWDASERDYLRREWQKTQDVEDTPPAKPPRPEPVPASARPLPDPMTYTPGTNRTDRYLASHAAPAQPVPSSHRPQDYSTTTEVDLENQRRAQSQARTKAGGWASKSLLEREMERERERQREWEEGQKDTAARARDISQGSAPGQSWDVHQYGYMGGDNQNRGGTGLGVGGARRQIIGPRPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A9S1</accession>
    <name>A0A0D2A9S1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241703.1">
        <property type="nucleotide sequence ID" value="XM_016376427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A9S1"/>
    <dbReference type="STRING" id="91928.A0A0D2A9S1"/>
    <dbReference type="GeneID" id="27329150"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02067"/>
    <dbReference type="HOGENOM" id="CLU_016738_0_0_1"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF5">
        <property type="entry name" value="TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="415"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="702" mass="75949" checksum="1481FBF0E6E4F1C3" modified="2015-04-29" version="1">MAEDPQPLTLQQRIAALNAAHVGRVPGEPPRPSPSHPPPIPNRRPVIVKQNTFNNPPESLHGSVTDRNVGNQPAPPPAAKKPPPPLPIRNNSLDEQRRGSVASTTSNGTVDTVSSITATQRGKSTDSLSRVKAPAWGESELPPLPPRGAPPQPLTRKYSDEKPKYVNRAPGCTTATTPASTREVKPGPPSRPSLPPRLPSRKSVNEGHDHAAESPGFKLPPIPTTAALEKAKRAAFPKTAQKQIAHVEVVSLVEPHVPMDQNNMALQHRTDADVHARDTVNLPIRDVISSFAKSKLQSQQHAPVAPPPVPLSSRPDLSAIQATKPKVSAANTAATTTPSNVCLTCRDFSGPDHQATLFPRTQVTSLQTLAHQLTSSFPSPTDKARAIFTWLHYNIAYDVVAFFGNNVKPSSPQSTLQSGLAVCEGYAALFTNIATYAGLESVVIGGHGKGYGFSALAPGAPLPPYSTGHAWNAVKIDNGEWKLIDCCWGAGHVQGAGQPYIQKFSPEFFAMSNEEFAIKHFPANGDQFFLPGGRRMSWEEYIVIDPACWPDGVEGPTVFTNAKEDYSIGEKSFYPRARRINVRQTGMIRFQFSLFCPHWTLDRHTRKGPPPVFIVSVEGVDGRHKDLIPMEYYPGPNGQGGDTWLVDIPARELGAPGQRITLFAVTTFGDRQDARGLTVQEFLNGKGRVGMGFVGVAAWDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AA57</accession>
    <name>A0A0D2AA57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyl hydrolase family 32 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241858.1">
        <property type="nucleotide sequence ID" value="XM_016376582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AA57"/>
    <dbReference type="STRING" id="91928.A0A0D2AA57"/>
    <dbReference type="GeneID" id="27329305"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02222"/>
    <dbReference type="HOGENOM" id="CLU_013784_3_0_1"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="75"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="496"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="71607" checksum="DD544829CE331022" modified="2015-04-29" version="1">MSAVEQPSSLDESAISNSTPSPNTVDDYANTASSVRSTELSDQEFGTTATSSAFSSRPSTPRSEAGFRRWRPGFHLIAPRGWLNDPCAPGYDPQRGIYSLGFQWNPYDYKWGNMSWGSALSLDFVNWDVSDSPAMEPTKTMDRCGVFTGCMLQRGHASNDTSEATDSDRSTTVAFYTSAQKLPITYKQPYTRGSEQLHLAISTDNGRSWIRTANNTILSEPPTDLGSSVRGWRDPFVAPWKALDRALGKNDSKPGLYGIISGSIHQRSPTVFLYELDKMDITRWEYLGPMNDISVNFSPSPWSGDFGVNWEVANFVDLVDSDGTAYSILIVGVEGVRNSSEGQERSELIKEHKQMWMSGSLGQQEGGVRMHYDFGGYFDHGCYYASNGFQDPVTGNFVTFGWIFEEDLSSGRVAQQGWSGCLSVPRAISMRSLHNVTGALRSRICDIGCVGSLEANGIYNLKVLGISPDPRLSLLRNHELHTRSTDQVVWFEEGMKRQWEFEGSFGVEESAIVGMEIAHDEDFATFTSILFSPVEEIVTIDRGRSTTDPGINTSPERAKHTLFSFANGTSETLDLHVFFDASVLEVFVNSRTAIATRIYPQGGKCFGVRWVLRHSGASDIMSERRPPTIQGTFWSLRESVRFCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATG9</accession>
    <name>A0A0D2ATG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230036.1">
        <property type="nucleotide sequence ID" value="XM_016386228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATG9"/>
    <dbReference type="STRING" id="91928.A0A0D2ATG9"/>
    <dbReference type="GeneID" id="27339004"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11921"/>
    <dbReference type="HOGENOM" id="CLU_011099_3_2_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="311"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW09820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="636" mass="70024" checksum="925E1DF775540B90" modified="2015-04-29" version="1">MALSSDSEGSPKLKSHVEKRVRNQGLTCKYLEAKRRGKGKKKEYVSTLEMKIARLENALRSGLPADRVSVGPSYASDHRSDEMATKTLGSTSEFGPGDVRPLAHTDGRSSTALPPTETEGPYTSRVVAQASGTRNSGSNLPTPKSSIGTSSAISAVRERFFASLPDSNVVRRLRTQMQHGGLTSSIFTHLSSKAHLETLFKEAYSNTNCQWPLFDHHSLIQLLDEEYASDGSSIHKSPARWGLLNSALAIAIQSKAAEDSYSGMIDLSWHFFKTSFGVFPAIAARGTDIVALEALLAMALFMQGSSDARTTSLLVSEAARLSTTLGFHRSSFYMGMDHITAERHKRAFWIAYILDKDISIKTRIPSSYNDDDISLGYPSPDSLGCPGKTAVSEIRVDAAVFRLRAQLAVIESCIQNQLYSEKATNCGPDMCSAAVSELNCRLEDWKGQVAATIRPGHVDWSTVGPGRETILALHLVYYRAMNAVHSWAAYHMPVDGINLASQSISSNFIHTTMAHASIQLLQFLPPLTPGCLWQTLFYPLSACLALVAVLLKHPADIGARSHLRHMSDFVQFLTQVQKRGVLDVERMRHLCIELEKLVFEIVTAEKNIAHSTKFPVGDQKIYEKIQVSPKRHLFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AU81</accession>
    <name>A0A0D2AU81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230524.1">
        <property type="nucleotide sequence ID" value="XM_016385580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AU81"/>
    <dbReference type="STRING" id="91928.A0A0D2AU81"/>
    <dbReference type="GeneID" id="27338353"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11270"/>
    <dbReference type="HOGENOM" id="CLU_013869_2_0_1"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW10308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="822" mass="91774" checksum="7F9F30D52D5A18C8" modified="2015-04-29" version="1">METNAPDAVAVSERACHSCRQRRVKCDKRIPGCLRCEKLGRPCTGYDTERKFLDEGAKVRRKYDGNLQTLPDLSRRHVTSPPTNPVAPTTRQEPSRNSPSQYQRLPIQSHTKAIPDIISQPTSSPLTLPGIASLSPRQSTPNVQYPLFGVNPPTSPGYNIFQGQAPQPFFSSSIPHPPANAPSHFPPAPQHPPQRPDQFQYGLEQGTAKLLRGKPQYAPSETDTYVSEDYFDLDIDTYYANGNNACGFIPGLPVILTDTNEPETDEDLLTNDYASLSGRSSVYDSSEGGRKRPEYSQKYLHERTTELAALTRHFVQVVSPSMDLFDLDTYFSRIVPLKAVQNVMLRSAMAAVAANQIGQLLAKGVTKTDLQHLVPLLGENGGLQETDWFYKAANYYDRGISYLRIFLQRWLSDTSNEMTGHTSKYPSRRFSDGSSKESSTLSAPNKRRRISEQSSAGADMEALVAAISVFSLYESLDNPTKDWSQHLDGFKALLDTKILPQAVTTPGPKASPFISMKASRAAFWNFARADYLAAYINRSKTRLDPDNLLVWKALGLPITDEGGLVYNDPSTPTNAMVSYQTRDREDMVSCALIWIVLRVMNFLAPHDDHNPETAAGTPNNVFDSPGTLAFRSPSETGASTPIQGRIARWKQLRRQLEDWYDNLPFTFQPYAMMGAASQHPYDQPPETRPRFTRIFFSVPMCAAALQLYHFAQILLLLNQPVDESAAGFMANRIRMFRKVSEESEHHSRQICGIALGKPPPAVSRQMVHSLHLAGLCFEEREDRLVVLELLGNIEKETGASTSQRARELREAWGWGPEVREVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVM4</accession>
    <name>A0A0D2AVM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_11439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230691.1">
        <property type="nucleotide sequence ID" value="XM_016385747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVM4"/>
    <dbReference type="STRING" id="91928.A0A0D2AVM4"/>
    <dbReference type="GeneID" id="27338522"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11439"/>
    <dbReference type="HOGENOM" id="CLU_043048_0_0_1"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW10475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48514" checksum="E77D4AB186504D46" modified="2015-04-29" version="1">MTDLVASTNNEGSRESLFQWAWNLALTPVRILTSRTAIKAYLGTLLFLITSTVLLTISSTAFGFFYYNYIPQINLERVLYLQYGEGPHPHATAALDTAALVSQQAYDVDLILDMPRTPINLEAGNFMLDLSLLGPGINVRNALQEPLSSWLSNITTENVFARSRRPAILPYSSPVLSLSNTLLHLPWHVLGFRDLDAAHLVVPMFEMVTFPRGARNIPTHARLEVQSSSVLQVYDAKLRFRAKFQGMRYLVYNYRIPAFVVFTALFYTVGVTSMGLAWALLSMLWSRKDDDGDRKVVKREGRQGKIKREEGGEDEGGPMIKEEEEEETDSSRHGLSLSNLSDTAAQFPTRTGQMPLRFQGRSPVPDAGQDQEADEHLTPPPGPDEVADDEEEEDAAESIRGRRFEGDSGIGTSMESEHQSSGIVRRRSSRGLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVU6</accession>
    <name>A0A0D2AVU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231079.1">
        <property type="nucleotide sequence ID" value="XM_016384477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVU6"/>
    <dbReference type="GeneID" id="27337245"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10162"/>
    <dbReference type="HOGENOM" id="CLU_573673_0_0_1"/>
    <dbReference type="OrthoDB" id="4120728at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="471" mass="53397" checksum="45E04DB945EC8D5B" modified="2015-04-29" version="1">MSKEAPGPRPFTFVDYNLNQRGVTDVARAHLMKDRVRSKREARSEWISRNQFSPLRWMRPKKGNGESSPDSIHESLNRVGESTGIASRPMSHYAAVIDFQKDKVINAPLSKGMHPVSPIPPKSDKRLKARRVRSYDGFSRRRSSVRREESLPEQPQQQATRPASRSRQPEMFKDPANMEDGELQPGSATKRRRRSQRSDSDFKLSLIEGLRIATPPNDDDQGLVPPRLDNEASNDMYAKLASIARRALLPPTALESHLIRYFVANAGGMLGFDRHQEIVEKYEPVVGLFLPFALASQWCFETMVLLFSAYHHRKYASSRRDAGFIDEEKEYMASQQNKILATTRSKVSALAHSKDSSDEDVVAFLFLALSEYCAGNRDIGLMHFEAWRKYCEMRRQLGIEACGLPCKTVVWWCTSMLVEDDVVLGSLLSPVTKAKVREEPEKLFKYFVKYTEGGEGIESKGPAALHKNITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYS0</accession>
    <name>A0A0D2AYS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231766.1">
        <property type="nucleotide sequence ID" value="XM_016385164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYS0"/>
    <dbReference type="GeneID" id="27337934"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10851"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_3_1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="94"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="496" mass="54330" checksum="560B9E5DE9BEAF94" modified="2015-04-29" version="1">MVEQPVAVGNLEKNEPSYKSDDESMSSSSAVSVPVVDAEPTGGDIEKTTTKSTQRTHRSNRSQWEKQITSAVDWTGDDDPDNPLNWGRAKKIYHVLIPAFQCFTITFGSSVISPAVREIAIHFNVSRTAAILPLTVYVVGLGLGPVMSAPLSETYGRRAVYLIFFPPSLLFTLGAGFSNSFASLVICRLLAGILGSGCLAVGAGTNSDLFAHFNRAVASSMFLVAPFLGPSLGPAIGGYVTMERSWRWTQWVILFAGAITYAVCIPQRETYKRIILQRRAKKLGVPGPPNPLPPGMSKWRFIFLVTILRPIQMLFTESIVAFLSIYVAFNFSVLFGFFAAFPLVFQHEVPEIRIYDFNQGESGLVFLGIGAGVIIAGAIFIVMDRLMYRKKTLKRRATGDFNPLPPEERLWPAMLGSVLLPVGLFWFGWSARKDVHWISPVLATIPFGIGNLLVFTSTVLYLIDTYGPMTGASAAAANGVLRYMVGAVFPLFTVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYU5</accession>
    <name>A0A0D2AYU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231816.1">
        <property type="nucleotide sequence ID" value="XM_016385214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYU5"/>
    <dbReference type="STRING" id="91928.A0A0D2AYU5"/>
    <dbReference type="GeneID" id="27337984"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10901"/>
    <dbReference type="HOGENOM" id="CLU_028361_2_1_1"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="60723" checksum="4B2B894391D47678" modified="2015-04-29" version="1">MSNNVSSHVATRVPTVDGAFGDPYDHEIALIDATDAADAPKQDGPRPSSSSKLSKVPTRGLVKDQLVKRKYAKWQAERLGTQSSLDGPDEARPTPGGVEGGDPAQPTDTVDFAHDGAVNRGQKSAEKRRRESKRLKHQVHEIDILYENQRGSFFCGIPLYSHSSLLPVDPGPWVNKDFHDSPVNITNAQVPDPSWEWAWKTWYVDMSHDVDEEGWQYSFSFGRNFSWHGTHPWFHSFVRRRRWLRKRVKRDDQTRRDRPGSLGAAHHLAGDYFTIHSKRDRSPASVDGTAKTARPASFLSYQSTVESEGPPEDIKDIASLLKALKLATVDREKIDVVKRFVNQAGDELHYLGEHIPDVMSFLVFQNSRTQLLAHLKKTADDARRHRQKHEDERRPEGDEESRRIDHLVKAVDAANAQIGGLEFWSDRKHVLKISDDNALETRAIATIFDAPAPQPEVDADPVKEIKGIPKSADLNGDRTASVFRQQTSPVDEREKEKQQDKGKGRARDPDNEDDEVEADLKATSTPRLRPDQLLVPDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZH4</accession>
    <name>A0A0D2AZH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_09372</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Also interacts with RBP1/DNA-directed RNA polymerase II largest subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232314.1">
        <property type="nucleotide sequence ID" value="XM_016383691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZH4"/>
    <dbReference type="STRING" id="91928.A0A0D2AZH4"/>
    <dbReference type="GeneID" id="27336455"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09372"/>
    <dbReference type="HOGENOM" id="CLU_062828_2_1_1"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="14">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW12098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="138" mass="14820" checksum="7C0375BC6E8A024C" modified="2015-04-29" version="1">MAGGKGKSIGGKATGAKDSSVKSQKSHSAKAGLQFPCGRVKRFLKNNTQNKMRVGAKAAVYVTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAFGGVLPHINRALLLKVEQKKKSKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZI1</accession>
    <name>A0A0D2AZI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_09133</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232076.1">
        <property type="nucleotide sequence ID" value="XM_016383453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZI1"/>
    <dbReference type="STRING" id="91928.A0A0D2AZI1"/>
    <dbReference type="GeneID" id="27336216"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09133"/>
    <dbReference type="HOGENOM" id="CLU_064620_1_1_1"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000017">
        <property type="entry name" value="Synaptobrevin-like protein Sybl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="155"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW11860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="249" mass="27507" checksum="CDEBD4E959BCCD50" modified="2015-04-29" version="1">MASSSGQSNQLLYACIAHGTTILTEHTSPGTSSSSASSLASVILPKISHSTPAKLTYTHDRLFVHYIADSPSSTSNGSDEQLSSHAALTYLVVAQTEMGRRVPFAFLLELKKKFLSQFKPDSTDFQSLPAYGTAAFNSTLRAMLQQYNTAPPSDALTNARKEIDNVRDIMTENIERVLERGERIDLLVDKTDRLGGSARDFRVRSRGLRRQMWWKNVRVMVLLVVVVIFLIYLFVGFGCGLPAWGKCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B163</accession>
    <name>A0A0D2B163_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_09936</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232874.1">
        <property type="nucleotide sequence ID" value="XM_016384251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B163"/>
    <dbReference type="STRING" id="91928.A0A0D2B163"/>
    <dbReference type="GeneID" id="27337019"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09936"/>
    <dbReference type="HOGENOM" id="CLU_013253_9_3_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238830" description="Peptidase A1 domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="59"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="432"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="325"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW12658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="522" mass="54223" checksum="B69EC4D49E03D6C3" modified="2015-04-29" version="1">MRSSLVAVLCLATVGLAADSFVKMNLHKDHVQRSKSMLARRQTDTLEEDITLAIEGSVYWLDLTIGTPPQQFKLQLDTGSSDLWVPAANATACVRDGHTCPGGAFNINKSTTAEITIPWSWEVEYGDQTGDAGDYFTDVVVVGNDTIPAGIMQLGLAMITVDGPQVQNDGHGLVGVGYSSLQSGAMTGLFDADKLPPSLTQALVQAGAIDREAYSLYLNDFESGEGAVLFGGVDSSKYTGELVALPILPTPDNFSDYTRFEIALTAISLTDQNGTHKLTDDDFAVPALIDSGTVAQTLPQPVYDAILGGLGATNDPNLGSPVVPCAYGDAGIYITYTFGGPGGPSIDVQLSELLGPGASDPSFYKGDVPACAIFINPATEDLGYILGDSFMRSGYFVYDLENNMMAIAQARLNSSEPEKIVAFSNGTDIPGATSTNTFTNVPTSSNSVEQPGAKTTSAAASATATGDVPIGSPTFAIGSVTSELGASSTGSSSSGNENSASTSTRASLWVAVAAGIMSFLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1J7</accession>
    <name>A0A0D2B1J7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inclusion body clearance protein iml2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with lipid droplet proteins.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233029.1">
        <property type="nucleotide sequence ID" value="XM_016382326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1J7"/>
    <dbReference type="GeneID" id="27335083"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08000"/>
    <dbReference type="HOGENOM" id="CLU_014926_1_0_1"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW12813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="776" mass="87004" checksum="DE66B0C0972627C6" modified="2015-04-29" version="1">MHRVGRWLDRGRAAATASTQSLDSLEESQNLETALRAVELVLNDDIAGAERNLAEGTSSFHRLAQGTLAFMKATLGFEQEVMKEASETLAEAESSASTSYHKAQRDSRVFNSNIYEKGSEFALCQAEAQIMSAVVGVLNESLTESIRGFYKLRKAYMTLDSLVQMEVAYMKARGVKSLGNSRNQSLESLPSATSAKSSQSNLVGKDTTQGNRPGEQPASRQPAHPSGLRNAELVGPIASDDPEADEFHEADVIHEKNPVTEGYTGHLEVTRAPEDMEELDRDIERMNLSHHADELHAEGVLKPPPPATTGMLTEDADSDTFSNSLDVFIHSGTNLMSGILSLLISIIPPAFSRLLYIIGFRGDRERGIRMLWQASKFSNINGGMASLVLFGWYNGLVGFCDIVSDSDPADPEDVEGYPGQRLQTLLKEMRTRYPQSHLWLVEEARMAASHRQLDNALDLLSSPGKSQLKQIEALHMFEKSLCAMNAHRYELCASSFLACADLNAWSRGLYYYIAGAAHLSLYRYDKTLTKEKAAEHAKLAEEYFRTAPTKVGKKKMMGRQLPFDAFVVRKMAKWEERATRFNCSFIDAIGVSPLDEMIFLWAGYKKMDERRLQRSLDNLAWSESSPRWEREDVDEQAILAILRAVILRNLRRHDESKEVLQEWILNRSPNDFKGQNRDDWVAPTAHHEMAVNLWMQRTGYRPSHGAEPMVSHGEESKTSTAVDLVHDARLVQNCKAQLEKAKNWDKYELDARLGMKITAGLNAVKHWEEKRGSITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B238</accession>
    <name>A0A0D2B238_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase [NADPH]</fullName>
            <ecNumber evidence="6">1.7.1.3</ecNumber>
            <ecNumber evidence="5">1.8.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_08145</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Energy metabolism; sulfur metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.7.1.3" evidence="6"/>
    <dbReference type="EC" id="1.8.3.1" evidence="5"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233174.1">
        <property type="nucleotide sequence ID" value="XM_016382471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B238"/>
    <dbReference type="STRING" id="91928.A0A0D2B238"/>
    <dbReference type="GeneID" id="27335228"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08145"/>
    <dbReference type="HOGENOM" id="CLU_003827_5_1_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="94"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW12958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="590" mass="66424" checksum="238385256499BBC4" modified="2015-04-29" version="1">MSTFSWRCGPCISKAYSSPLTSTCSWRICSAKVTSLVPFRPVSTTSRRPQEHHRRSIWKYVGAAVLASATVAGSVFEWKDAHAEASPNIAHLQKRYIRLGEVERHGRNSDRKWVTKGSRVFDITEWIEAHPGGPVILQAVGGSIDRYWDIFSIHKKQDVYDILEQYCIGEVDPRDLVDGKVPEDKIEDPFQSDPARDPRLLRHTDKPCNAETPSQEIAESFITPNRLFFVRNHFWVPKIDEGKHVLHVELPDGTEKAYSVAELKSNFKPFSITATLQCTGNRRKHMSENAKPASGLPWDVGAISNSLWTGVRLRDVLADAGYSLDRDIGDDDVRHVHLVGAEAYSGSIPISKAVDPHGDVMLAYEMGGQPLPRDHGYPLRALIPGHTAARSVKWLERVVLSEEESQSQWQQRDYKCFGPNQASMDVDWSSAPAIQETPVQGAITAVSVLSRDSRKGRADLTKYGIEEDAIRVEGYAFSGGGREIVRVDISADDGKTWSQAELRSDETQGHKSWSWKRWEWVIPKATAGRVFVVKAVDDSYNSQPESYDAQWNFRGNLTNAWHRVALSEDDQNADASPKQSWFWRMLRKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3W2</accession>
    <name>A0A0D2B3W2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233586.1">
        <property type="nucleotide sequence ID" value="XM_016382883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3W2"/>
    <dbReference type="STRING" id="91928.A0A0D2B3W2"/>
    <dbReference type="GeneID" id="27335641"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08558"/>
    <dbReference type="HOGENOM" id="CLU_067676_7_0_1"/>
    <dbReference type="OrthoDB" id="4863010at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26663" checksum="85864D41622C1617" modified="2015-04-29" version="1">MASQPQSSPVHAPPHVLKLLSELHQKSIQQEAAIEGGIGKYVTSETKGQTEAGGIPGYTDFDRLMVDKFIALDEDKCQFMYQLIQAMGATNVVEAGTSFGVSTIYLALAVARTTAVTGKQGVVIATEKETSKAQVARQYWAQCGDEVEKQIDLRVGDLRETLKVDLPAVDLLLLDIWTPMVLPTLKTVLPRLRHGAVVLADNTISSAKGYEEFLTFVRNPENGFRTMTLPFNNGFEMSVYLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4K5</accession>
    <name>A0A0D2B4K5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_06649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234084.1">
        <property type="nucleotide sequence ID" value="XM_016380982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4K5"/>
    <dbReference type="GeneID" id="27333732"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06649"/>
    <dbReference type="HOGENOM" id="CLU_2306170_0_0_1"/>
    <dbReference type="OrthoDB" id="3497702at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="102" mass="10748" checksum="84C799B472C9BDAC" modified="2015-04-29" version="1">MSPSVSIHVEDRISGKNANANVPVNGHKETFGSLFRNTPFGSQVLANAILVQTPGTAQGVKIVVFDAHGNQQAVLDDNGTPFVIGTASTTDITNWTISATRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9M1</accession>
    <name>A0A0D2B9M1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal lysine N-methyltransferase 4</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05707</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235874.1">
        <property type="nucleotide sequence ID" value="XM_016380047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9M1"/>
    <dbReference type="STRING" id="91928.A0A0D2B9M1"/>
    <dbReference type="GeneID" id="27332790"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05707"/>
    <dbReference type="HOGENOM" id="CLU_017135_0_0_1"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011383">
        <property type="entry name" value="N-lys_methylase_SETD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011771">
        <property type="entry name" value="RMS1_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="28"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="550" mass="61478" checksum="D59492E2EE6F910D" modified="2015-04-29" version="1">MDSSSEFETQSTTFLDWFKAQPGTQFHPSLKIVDLRDRNAGRGIIATQDIAADTDLFTIPRDIIISEETSTLAKKLPELFSKATATAAAATANTNVDIDDDDDDDDDIDVDDESDPSVPDSWLYLILILLYESLHHTTSQWLPYLSILPQRADSFNTLMFWTDGDLSALKGSAMLNKIGKESANRMFTERIIPVVRRHADIFYPGGDSQQQQQQLSDSALLERCHIIGSLIMSYAFDLQPDEDEEDADSDTEMAGVEEDGWIEDRAAPGAGAGSSSSTKSTMGMVPMADMLNADAEFNAHLSHGDDSLTMTSLREIKAGEEVLNYYGPLPNGELLRRYGYTSPKHARYDVVEIPWSLVKTVTRGYDDYLPQSQTQKRRQTQIQAQVDKILDEIERDEDNRLGLDLDLDFDDGVENDDSAAFVLERDSGDPDDQGLCVVDAKFVSFPEDMVNVVGHVVTRVLSSSSSTTKPFKSKKDEAKRIKGVTLDILKSIVLRRLDLYPTTLAEDQNLLLNTTTTIRERMAVNVRLGEKRLLVEALEWTESKLTKYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9R5</accession>
    <name>A0A0D2B9R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235586.1">
        <property type="nucleotide sequence ID" value="XM_016379759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9R5"/>
    <dbReference type="STRING" id="91928.A0A0D2B9R5"/>
    <dbReference type="GeneID" id="27332499"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05416"/>
    <dbReference type="HOGENOM" id="CLU_028612_0_0_1"/>
    <dbReference type="OrthoDB" id="5414836at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122:SF1">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238887" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="45380" checksum="2E9C1347333AE642" modified="2015-04-29" version="1">MIYKIGAMRLIAALGPFIVTLVQAGGGGGGGGETTTPCAAGWVDWSTSYVTVPTTIYSTVYSTETDYTTVTTTSVEIQITTIVDTSFETSYISVPVTVPTTIVDTSIETSYVSVPVTVPTTVVETSVETSYISVPVTVPTTIVASTTIVSPTTIVSEKTITSVDVSTVTDVTTTTVVSSTCPPPPLTGLVTCTSRTVNPTYTPKAPLPSNYLWGCPPGTICTPPQIDCNWEQNPPADDYVCSPKECKPLPDFDIPTDWNTTWPNPTEADCAWYEPTLGYFHLDPRLFDLSFAIFDVYGQPVCPAAAAPPPSSTTSGWADWTTPTATRTPRFPRRGSKNILAEIVSRQSLGIAPAACYEVFDNTQLVAQLTGKVYDQLCLDQTPFMKGVRSCQACAATNGGASSTTTSFPKLLAYFNWCQSQAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BA73</accession>
    <name>A0A0D2BA73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236109.1">
        <property type="nucleotide sequence ID" value="XM_016380282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BA73"/>
    <dbReference type="STRING" id="91928.A0A0D2BA73"/>
    <dbReference type="GeneID" id="27333026"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05943"/>
    <dbReference type="HOGENOM" id="CLU_018204_10_1_1"/>
    <dbReference type="OrthoDB" id="5356974at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000020">
        <property type="entry name" value="Putative acyl-CoA dehydrogenase YdbM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000025">
        <property type="entry name" value="Related to Dibenzothiophene desulfurization enzyme C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000032">
        <property type="entry name" value="Thermophilic desulfurizing enzyme family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="258"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="46638" checksum="FD28B7500381CEDE" modified="2015-04-29" version="1">MGSVDPTTASPDHYSKFASLGLPKTAEQWLARGREVAQILAVDAAQRDIENRSPVKEVKLLKAAGLTKVLGPKEYGGGGQDWSVGYKLIREVAKGDGSLGMLLGYHLLWSTTANVVGTDEQKHRTQKLILENDWFIGGAVNPRNADLKITSDGDEIVFNGHKNFNTGGVISDATILEGVLEGTDQHIFALVPTRQPGIQFGHDWDNVGMRLTESGSVRIDNVRAPWTDALGWDAQTKKPIDAVLKIPFASLLLPTIQLVFSNFYLGIGLGALDEARKWTTTKTRAWPFGGDNKERATDEFYILSRYGSFFAHLRAAEALADRAGDEISSLYADHGEKRDVSAERRGEVAEWVASIKVVATDEALKVAAGIFEVTGASATVRKVGLDRFWRDVRTHSLHDPVAYKERELGRYFLLGEAPEPTWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAD8</accession>
    <name>A0A0D2BAD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05551</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235721.1">
        <property type="nucleotide sequence ID" value="XM_016379894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAD8"/>
    <dbReference type="STRING" id="91928.A0A0D2BAD8"/>
    <dbReference type="GeneID" id="27332634"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05551"/>
    <dbReference type="HOGENOM" id="CLU_020105_4_2_1"/>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="5">
        <location>
            <begin position="26"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="123"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="577" mass="63748" checksum="9BB63EAEFBD238A0" modified="2015-04-29" version="1">MQFATFSRAQPDILQASLLRQIVAGPRARHPEAGLDLCYVTDYIVVTSGPSSVWPKKAYRNPLDQLVSFLDRKHGQDWSIFEFRAEGTGYPDKEVYNRIHHFPFPDHHPPPFALIPKVMAAMRNWIQRCDEATQEADTQNQRPRIAVVHCKAGKGRSGTISCSYLISEEGWDKQKALAQFTNRRMRAGFGQGVSIPSQLRWVDYVDKWTNQMGKYYKDVPVEILEIHIWGLRDGVTVTVEGYVESGRKIHKYHRFTRQEMTLLGETSDERASISSSKKDQHVLSTPPAGTPRSSTVSLSTSANTSQDVILKPSTPVVLPSSDVNIDFERRSKATAGFTMMTALAHVWFNAWFHGGYDGHNSGTFEIKWEAMDGIKGSSRKGTRALDRLAVVWRYREDGSDKVVPEPAKGEPVPENPPADWRGEDNPEAKPADGIDSGRPGGALLTMGATINEGASTLGKELGLKEKESESSSESLEGKSIRKAAGVQQAEEDSGDEGVRTYGLNGESHVPYREEDEGRKDTATGHRMEAGLAKAAHIVSKMKPSGQKKDGERETPGSHVHGEAKHAMDSSDPSRSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBJ5</accession>
    <name>A0A0D2BBJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_06434</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236599.1">
        <property type="nucleotide sequence ID" value="XM_016380772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBJ5"/>
    <dbReference type="STRING" id="91928.A0A0D2BBJ5"/>
    <dbReference type="GeneID" id="27333517"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06434"/>
    <dbReference type="HOGENOM" id="CLU_020273_3_1_1"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW16383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="235" mass="25324" checksum="E6538A0DCCD84968" modified="2015-04-29" version="1">MPSSSPLPKGFDSIESTIEAFRNGEFIVVLDSQDRENEGDLIIAAQDVTTEKMAFMVRYTSGLICAPITAKLAAELKLPLMVADSEDPHRTAYTISIDSNDASVTTGISAHDRALTCRTLASSKVSPASFRRPGHLFPLIAKDGGVLERTGHTEAAVEFCRLAGKARAGVISEMVDDGEPVQGQTLMREPGMMRRDACLAFGRKWGLKVCTIEDLVDYVQHEKGVASNGVVNGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BC82</accession>
    <name>A0A0D2BC82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236784.1">
        <property type="nucleotide sequence ID" value="XM_016378107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BC82"/>
    <dbReference type="STRING" id="91928.A0A0D2BC82"/>
    <dbReference type="GeneID" id="27330839"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03756"/>
    <dbReference type="HOGENOM" id="CLU_002329_1_0_1"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1163" mass="131461" checksum="55A06F9F70E5DF64" modified="2015-04-29" version="1">MPLLRRLSSSFKKNKHGHTNGIKNGATNGHLTPVDESHTTETHETTPGSSVAQSLAKTKDVERNGSHTQSMPPPPAEPASSNTDGPASRKDVEDVFQQFAQLIHASRRPLPTQSGDGQYLEKQESSGFLADLKSLGLKDVRTVSHMLEDKASGKPQDDRKMHMEEIMQLIAALPDHSANRVQLTGTLLDVLWNSLQHPPMSYLGDEFRYRSADGSNNSYIFPKLGAANTPYARSVSPVTIQPGALPDPGLLFDSLMAREEFKPHPNKVSSIFFNWASLIIHDLFQTDHQDYSISKTSSYLDLSILYGDTQEDQDNMRTFKDGKIKPDCFAEERLLAFPPACGVMLIMLNRFHNYVVDQLALINENGRFNKPSSKLPSEAASRAWEKYDNDLFQTGRLITCGLYINITLYDYLRTIVNLNRTNSTWTLDPRLDKPKTFGSDGTPRGVGNQVSAEFSLSYRWHSCIGQTDEAWTEAVYQELFGKAPDEVSLQELMVGLGKYDHEIPEDPLKRPFAHLKRGDDGKFDDGDLAKIMQTGVEEVAGAFGARNTPKCLRAITVLGIMQGRAWNLCTLNEYRKFFGLKTYDTFEEVNPDPYISEQLKHLYEHPDFIELYPGLAVEEYKQPMVPGVGICPTHTISRVVLSDAVALVRGDRFYTLDYNPKNLTNWGFNEVAFDLSVNQGCVFYKLLLRALPNHFKPNSIYAHYPMTIPSENAKIMKDLGRYHDYDWSTPTYIPTRVNLTSYQSAKYLLERPQDFTVMWNDGLGFVMGKGGEKFCLGGDTRLHRKQRELMHGLLYREKWHEHVKAFYQDITLRLLHEKSCKIANVNQVDLTRDVGNLAHVHFAANIFALPLKTHKNPGGIFSEQELWMAMCVIFTAIFFDFEPTKSFQLRLVARKLANMLGKLIEMNVKSVTATSFASKLFDSFRENDNALAEYGVHMIRRLSESGMSTYDMAFSQIMPTATAMVPNQSQVFSQVMDYYLGDEGIEYLPDIQRLARIDSKESDEKLLRYVNEGIRLNGTFGSYRRSEVNHVFNDGNRQVTVKPGDKVFCSFVAAARDPSIFPDPDRVRLDRPMDSYIHYGIGDHTCLGKDASMVALTAMLRTVGQLNNLRRAPGPQGQLKKVPREGGFYVYMREDQSSYFVFPCTFKVHFDGPLPALRSSTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCC6</accession>
    <name>A0A0D2BCC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236844.1">
        <property type="nucleotide sequence ID" value="XM_016378167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCC6"/>
    <dbReference type="STRING" id="91928.A0A0D2BCC6"/>
    <dbReference type="GeneID" id="27330899"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03816"/>
    <dbReference type="HOGENOM" id="CLU_647293_0_0_1"/>
    <dbReference type="OrthoDB" id="2142961at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="424" mass="45616" checksum="A4F8E2511D88FC21" modified="2015-04-29" version="1">MSMIESTSHTHAKGSRRSGKKNRPSNPHDGFVSDVGAPTEHQRNNSPASNAVKNNGKGHPRKNSSAQNTAASVGKHDKMKATPMKPAAYAGATFQQSPAASALPLPSFYSKSMPAAGPLTSQISDEASADTRPAAQQVTASPNKRETTPCDFLFDAARQARATPRGDTPGARSGNMSISNGSPASGSPAPRDGDPMFPFELDGASAAGEDGAFSATPYKDRIEALKSTRSTSLPSKSMNEHERKAKTDALKRLLMKSSGQPHDNNFQPVQDMSNPFNARAPYQPPPAPNQGPPLVRHTSGPSTMFKQDQSGYGAPQAFPQMPYQYQPTQIQTPKRPNSSSLRNVYGAQSEPEYAELSSDSAVTPPVSTQRRHTPQYIPQYNTAAPLDSPYSKQQQMPNHRAKPSAQQLEDDLRRVLKLDLTTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDL9</accession>
    <name>A0A0D2BDL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236936.1">
        <property type="nucleotide sequence ID" value="XM_016378259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDL9"/>
    <dbReference type="STRING" id="91928.A0A0D2BDL9"/>
    <dbReference type="GeneID" id="27330992"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03909"/>
    <dbReference type="HOGENOM" id="CLU_022620_4_1_1"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="88"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="376" mass="42057" checksum="2CB06F80F3B02419" modified="2015-04-29" version="1">MIEDDGYRSSSQYRLWSYTKNSLTQIRQNTNNIASEHVKAAFRRAQAAKASQNGSNESIENQGQGETAVDIQTLTIDEELKIVEWGCSKMQDMGEAMNPRIPSHVVATAIQYLRRFYLTNSPMTYHPKQIIACALYLATKADHFYISLSKFVAELEEMTEDNVKAPEFLLLQGLRFTLDVRHPMKGLAGGHIEMNVMAEEGQLGNISTSSGSAKRIGQAADQAKKLLATAAQLTDAYFLYTPSQIWLGAMMVADKELVEIYLEQKLSQLQANAHVTAIKEKIVSTIVECAALLESYRSPNDDATQRKEMRRIGKKLTVCQDPEKLDIVAVARAKAAEKREGEGSDTEKAMKKRKLERERLEKDGDVFGPELKSIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDN3</accession>
    <name>A0A0D2BDN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_04229</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237254.1">
        <property type="nucleotide sequence ID" value="XM_016378577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDN3"/>
    <dbReference type="STRING" id="91928.A0A0D2BDN3"/>
    <dbReference type="GeneID" id="27331312"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04229"/>
    <dbReference type="HOGENOM" id="CLU_028341_1_0_1"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="559"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW17038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="608" mass="67919" checksum="A190DD6237987C98" modified="2015-04-29" version="1">MQYLPGLFGVEPGLSAMASAGYIQITLIWVVYAIAVAILLSIASLFVYLYQTHRERSVLVTIVCIFTITCLLATVLLLPVDVALVSSTTSSKQGRRKDWANQGKVDNITYTLRIVYYLLYSLDALLCLIVVPFTYFWYEEYDEVAQEEGSQTFGSRFWAAFKYTLIFIFLCVALFVVGFFVPVARDRGGAHFDLDFFKNLLSENHGERALTFALGLLITIGVLMYCFYTAAGLALLPLTLIKSAPGISAPALSETTASQLESNLERQRQLEGRAQGNPEGLSSKDQRELDALVREERTLRRHQRLAAEAAGEDRNIFWKIWIKIEAVFRPIKLILGILLVVIVLLIFASMLITGIDKAKNSICKRHCGYLLARINIFQPINWILVKSAKVFPIDYIIFLFLVMLFFSASIIGIATIGIRVLWITIFRIRKAHTSPQALLIATVMLTLMTLAINYSIAMMVAPQYATFGPQTFCDHPPKHPGEQPDCSDHPQHIIPCTEISDNPAARNVCTPSVVSTFLNRVTVNFPFFGVVDFWAQFVFLGIFLLGFVVLLFRTPKLSDPDAEEDDLEEEEEGLLASTGRRFGATWQDITGRAGRPGGRGTRDATGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDQ6</accession>
    <name>A0A0D2BDQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chaperone DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_04264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237289.1">
        <property type="nucleotide sequence ID" value="XM_016378612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDQ6"/>
    <dbReference type="STRING" id="91928.A0A0D2BDQ6"/>
    <dbReference type="GeneID" id="27331347"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04264"/>
    <dbReference type="HOGENOM" id="CLU_017633_10_0_1"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="149"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW17073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="46237" checksum="9D0B3941983C5D9C" modified="2015-04-29" version="1">MNGAPDAAEEIDLYGILGVPKDASQADIRKAYRKMALQHHPDKVPPEQREESEARFKAASQAYEILYDDEKRHLYDAHGMAAFNGGGGPGGMGAEVNMEDILNMFGMGGGIPGMGGMPGMGGGGGRRKMRRSPDENQKYEVTLEDLYKGKTVKFSSTKNVICSKCNGTGGVDKAKPKECSACKGQGVKQILSQVGPGMLTQRMVECGACEGTGEVWNPKDKCKKCKGKKVTEERKQLELYIPRGAREGDQIRLEGEADQVPGAEETGDIIFHLVEQPHDVFQRTGNDLSAKLEITLAEALAGFHRVVVKHLDGRGIELLHPQTPGQILRPGEVLKVPGEGMPLKRSDTKGDLYLVVEVTFPEDGFFTDPAALESLQKILPGPPPPIEVEEADEVPFEVADIDDIGGQEAGNAWEDDDGPQQAQCQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEC1</accession>
    <name>A0A0D2BEC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237156.1">
        <property type="nucleotide sequence ID" value="XM_016378479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEC1"/>
    <dbReference type="STRING" id="91928.A0A0D2BEC1"/>
    <dbReference type="GeneID" id="27331213"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04130"/>
    <dbReference type="HOGENOM" id="CLU_005620_0_0_1"/>
    <dbReference type="OrthoDB" id="4489171at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="826" mass="92585" checksum="564090A338E4A509" modified="2015-04-29" version="1">MAAAHPTQDQISQVVAITQADDSAAKFLLMKSNNDVNAAINAYFEDPVGSLKEPPPANQWQEQDNVPFADDSSMGGMPALSRPPSRVDGSRSFVDLSADHAAANSKDAKTLREQEELNDPEIQRAMAESLRQNGPAQENGITGTGAHFGPANRDYYDPSNWALTTFSTAREIIDHPPPSKRRRIDDQPAFLRGSKETDYLAPLLTIYHSIPLAREALLMPGLKIHAYGHDDSWWSGTNDENTKSLSTDNNLRVDRDDCNVLAEIQCLMAFLDKTNRAYGSVDALADLHRVRNNNDPSSFVRVMQAWSSAALNQDPNEQLTQVFTSTAVKENGPENSRQEEEMVCVEPYVNPSLGQTLVDVLDNTVWNDERGNIDDVWIDHAAEIFTIRVRDPDTGKSEMNLHLDPVWYPDRYMQECREASMHIRKELRKIHWEVEQCTTIQRRCDVLRMPDNRVLMVRDVLNAASKASLGVAGRKPTSDALYGGQDSMGMTEDAVSSREVEDVRTELQLVLQRIQQKFQQLESRKAQLRHTMRQIAAHLTRPTSESPDFPRRKYTLQGVSTTTNITYVRRPNQDLLRLNDDESSSEDQEGQWWKMAWLQEESSTVPLAPVAGPVTREQAHNDPTTAAAGISTEREQSKQYTVSKVSEKDVLEAVKSAHQSVLLVYATENAMKFKGTELSLPLRHFVDRDNQAFAEELREEEATLSNDSGDHELETEFEDVPLIDQTGSSSSVREFTPMSTSSPGIRDEEGQPSPKRAREGDSGFHPELPPSYEETVGRPEMQERKGNKIGFHAEQMLQKYGTTDSATDIDEKANPEGDPVRLEHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEL0</accession>
    <name>A0A0D2BEL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_11930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230045.1">
        <property type="nucleotide sequence ID" value="XM_016386237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEL0"/>
    <dbReference type="STRING" id="91928.A0A0D2BEL0"/>
    <dbReference type="GeneID" id="27339013"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11930"/>
    <dbReference type="HOGENOM" id="CLU_020027_14_1_1"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="10"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S12 Pab87-related C-terminal" evidence="4">
        <location>
            <begin position="432"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW09829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="59704" checksum="08E0C94B2AE2EFFF" modified="2015-04-29" version="1">MESFQSEVFTNRVQALMSQHHVPGVSIALVQNDQIASRGYGSATLDPVVPCTPDTLFDIASSSKSLTAGCVGLLVDDDERYPDVRWEAVLSELLPDDFVMSGVGYTEAVTVEDILSHRSGMPPHDSSSMGPRAAHPDDARSVTRNLRNLPVAAPIRSKYMYCNMMYTVATHLVEVKSQQRFSDFLQDRIFGPLNMPSTSLQPLMARSRGHGHRIATGYSWNKSKSAYTIYESPDCPAEQGAGSVISSANDFVKWVKALMNHEPPITQSLYQGLVRLRTFTNPSMQRLKKHTSPKFYAAGHEVYFYRGVMVIGHDGCIDGFASRFFFLPDFMFGAVILTNSNDGTGLATILARELIDSVLGTDGNNGPRKAQLPTRPKPRNPQKLRLPIQADGTATSDRTRQSHDGFRSNHKGDTSTQEQSDPDTGSTVRPSDPPIEQLDTLTGEYTNPGYHSLVVQMKDRKLFVDATDRSDRFFLTFDYVRDQTEYVAHFHRSLDLESFEDIRAEFVFENGRAVRMGLHMEPALKELIWFERVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEM9</accession>
    <name>A0A0D2BEM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_11945</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230060.1">
        <property type="nucleotide sequence ID" value="XM_016386252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEM9"/>
    <dbReference type="STRING" id="91928.A0A0D2BEM9"/>
    <dbReference type="GeneID" id="27339028"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11945"/>
    <dbReference type="HOGENOM" id="CLU_067152_1_0_1"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11000:FF:000002">
        <property type="entry name" value="Fe-S cluster assembly protein DRE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11000">
        <property type="entry name" value="Fe-S cluster assembly protein Dre2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S cluster assembly protein Dre2 N-terminal" evidence="12">
        <location>
            <begin position="25"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="227"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="302"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW09844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="328" mass="35388" checksum="C3CDCF8CFCBC634A" modified="2015-04-29" version="1">MSPSILMDTSDDFVMPVAKAPQSSKRTLLLSPPSLSSHQEKLTNVLEMHNRAVTDMQMLDRLAAGFVSLPQSTYDVIIILSDADGSRQESHALLHRDVLGLLVKALKNGGQLRSQDGQYGNVDGAEKNEAILAGLSYQSGTGFFKPDYGAQESVPLKFGKKKNVAQAAGGLSTNGGSVSLPLNGKRKSGDNVLDGVGFDDGTMDSDDELIDEDELLDENDLNRPIKIPTECKPKAKRRRACKDCTCGLAQKLEAEDRARRENADKALNTLKLQSDDLAEVDFTVQGKVGSCGNCSLGDAFRCDGCPYIGLPAFKPGEEVRLLNNDIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFF3</accession>
    <name>A0A0D2BFF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230280.1">
        <property type="nucleotide sequence ID" value="XM_016386148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFF3"/>
    <dbReference type="GeneID" id="27338923"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11840"/>
    <dbReference type="HOGENOM" id="CLU_2941714_0_0_1"/>
    <dbReference type="OrthoDB" id="10494312at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="60" mass="6937" checksum="8A72D9D37C4D1BC4" modified="2015-04-29" version="1">MLTIPTDREFRDVAARVTLPAEEFIPEPASEGIWRHLPSAQEPNEHAQRLVELYNKFYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFI9</accession>
    <name>A0A0D2BFI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230330.1">
        <property type="nucleotide sequence ID" value="XM_016385386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFI9"/>
    <dbReference type="STRING" id="91928.A0A0D2BFI9"/>
    <dbReference type="GeneID" id="27338157"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11074"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_0_1"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="350" mass="39377" checksum="FC2AB904FCB6985E" modified="2015-04-29" version="1">MQMQEVLVIGGTGAQGLVVVNALSSSKRYAVRVLTRDRNSARARTIANLANVTLVEGSQDNQQDLHRAFHGVYAAWVNTDGFTLGEKNELFYGCRAYEIARSEGVQHYVYASTDFALKDTNWDENYHWGHNDAKGRVAEYILAQGQQGMKSSILTTGPYMNMLWDGMFVPKEKEDGSFVWANPARSGKIPLIALEDVGVYSLWLFDNLHESSGLELKVATDEVSFQEIAATFTQVTGKKGVHQYVPLDEYMPAAEPYPNAPANYAAGPNAVRDESSMTWRRNFSAWWRYWGEGRCPPRDMALLDRIHPGRIKSLAEWMRLVGYDGIRKNVLKGNEDLRRQAKSVQQTKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGD9</accession>
    <name>A0A0D2BGD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230635.1">
        <property type="nucleotide sequence ID" value="XM_016385691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGD9"/>
    <dbReference type="GeneID" id="27338465"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11382"/>
    <dbReference type="HOGENOM" id="CLU_046006_3_1_1"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13669">
        <property type="entry name" value="Glyoxalase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21307" checksum="587529F2216F1358" modified="2015-04-29" version="1">MTPSSASPSGMLGNIAEICIVTPDIYRTIDGLTMLGIGPFQIFEFNSATVPRQQHYGRRGTDLFRIKAAFAKQNSLVVELMQPLAGGSEKSLMQKFLDDNGGREGVQHIAWDMGGIPMAERLAKMRERGFEPAMQGWWQGRKGQCHFCFFDTLEKGAGTVFETIDFSEDWEDPECEWYPRQSVPEDKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BH47</accession>
    <name>A0A0D2BH47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hsp70-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238539.1">
        <property type="nucleotide sequence ID" value="XM_016376969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BH47"/>
    <dbReference type="STRING" id="91928.A0A0D2BH47"/>
    <dbReference type="GeneID" id="27329694"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02611"/>
    <dbReference type="HOGENOM" id="CLU_009958_6_2_1"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF79">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="78816" checksum="2543C8242025301B" modified="2015-04-29" version="1">MTSRLKSLGFGSKRKSSANIQSNSVASPNGSISTTATTPPPPNSSQTSLPPMNQQGAPGRPPSYSYQTVQGRPQSPLPPPQNQMAHHPPPIDTRQGYMGGNPQLGPPQPPGYGGAYAQIGPQPGIQHTANQYAPGRAAEVEASNRNKAQLIVGIDFGTTFSGVAYAFATNTEAKEDIISEWPGAGNQTKQKIPTVLYYDQYQKVVGWGPDIAEALAPTGYPKPGVQKVEWFKLQLMLSGNTYIDPINLPPLPPGKSEIDVAADYLFKLRNAMRVYLGKTLGEVFNREERNIRYFLTVPAIWNDAGKAATRAAAIQAGFIRDENDNRLTLITEPEAAAMFCSKTGLLNLKIHDAVLIVDCGGGTVDLIAYEVEEETPFSVAECTAGSGDSCGSTALNRNFSNILRAKIRRMKLPDGSKTAGRVYAKCIMDFENRIKADFRNNGQKWAVDVGIEAEFPEAGIEEGYMTFTNEEILQCFEPVVNRILELVRNQIIAIQAQNRSLQNVLVVGGFGASEYLFQQIKLHVPPQFQSKVVRPMDSVAAIVKGAVTAGITERVVTSRVARRHYLMATLQPFKEGYHPEQYRVPSLDGKDRCKYTRQIFVQKGERVKIGEPVKVSFFRQVAPGATLMYEDILYACDEDVCPEYTKDPRIKEVVTLTSDLSRKNLEKDFERMDTPQGTFYRVYFDIYLTLDGSEFNAELVCQGEVMGRCTARFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHP2</accession>
    <name>A0A0D2BHP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231110.1">
        <property type="nucleotide sequence ID" value="XM_016384508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHP2"/>
    <dbReference type="STRING" id="91928.A0A0D2BHP2"/>
    <dbReference type="GeneID" id="27337276"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10193"/>
    <dbReference type="HOGENOM" id="CLU_012358_2_3_1"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006056">
        <property type="entry name" value="PRK08204.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF5">
        <property type="entry name" value="CHLOROHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="57"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="478" mass="52205" checksum="E4C27588E1D0A171" modified="2015-04-29" version="1">MASSLLLRNATVISVDEKIGVKENCDVLIEDGVIKEVGPNLSSGTSGELIDCSHCLVSPGFVDTHHHMWQQLIRGVTTDWSLANYLEHIRLVYGSIFTPEDVYTSNHFAALDLINSGVTTVIDHCHILNSSAHSDAAVKALKDAGIRGTWCYGFYENPSQADLPGSNHTVSTPAGFDKAARRADARRVRQQHFPDNDPNEHLLTFGGAPAEAEGMSPEALQEEIDFFRSIGARVTTMHVSLGNYDFDHQIVQRLGDDKYLDKDLLFSHGSSFTDSEISLIEQSGAGISSTPETELQMGMGHPVAFKAAAAGCHVGLGIDITSNQNNDMLAVMRLLLQAERGRRHLEVLGQAPPPYDIQPKSEEALYMATMGGAKSIGLDHLIGSITPGKRADLIITRCDDMNVVPVTHPVGALMFNAHVGNIDTVLIDGKVMKKDGQVLNVDWPKLRDEVRQRSARMLETHSKAPLPSKNMWTKVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHY2</accession>
    <name>A0A0D2BHY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_02816</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238744.1">
        <property type="nucleotide sequence ID" value="XM_016377174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHY2"/>
    <dbReference type="STRING" id="91928.A0A0D2BHY2"/>
    <dbReference type="GeneID" id="27329899"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02816"/>
    <dbReference type="HOGENOM" id="CLU_003525_0_0_1"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106006">
        <property type="term" value="F:cytoskeletal protein-membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07651">
        <property type="entry name" value="F-BAR_PombeCdc15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000045">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000164">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="17"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="917"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="623"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW18528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="982" mass="106880" checksum="9210337E387C4358" modified="2015-04-29" version="1">MPPGTASETGAPPSVPLSFSNNFWGRDDAGVDPLLTRMQNARTTCDELKTFYAARAALEEDYAKKLHNLSRKPLGSVEQGTLRASLDVARGETEAMAKQHGLIAQQMKSELEEPLAAFAGGMKERRKIIQNGIEKLLKTKQAQTAHVNKARDKYEQDCLRIKGYLAQGHMVMGQEERKNKAKLEKTQINMASDSQEYEAAVKVLEETTGRWNKEWKAACDKFQDLEEERLDFTKSSLWAFANIASTVCVSDDASCEKIRLALENCEVEKDITNFIRSCGTGQEIPDPPRYINFCRGDVDSQSELSEDENYSVAQFSRTTNPAFRSSSPTHSNVTRSTPQRMSEEPTMPDEDDLRTPSNTNSGRPPPLNYKHTGPNVPPNYSPSQHGEVPQVPHNQYPTDGMTMFCRTDAAPSVTGSALSSNTRPESRDSESQYSVPSSFTSADPMSGANSPTKMAPAGGVELPGMASPERSIQKKRSGFFSNSPFRRKSRKDHDTSTTSPQSGNPWSSNLTSSGRINLNAPGSSTQSSPTKSPTKQSTSFFNRNTAATSLEGEEPVDPRANFQLNVGNNVFDVASPDGQDSTPKASSANRRSQFLPPPSSMGDDVMNDPIAQALADLKRTSNGFTGMAKQSSTRVPVDRYHGVATPAPDQDPALRPGVSSAESQARLAAQRGTPPPAYEPGGARQSVLGVPQPAHTKKEMLNRTETWGTGSVASTPKGSQQTRDGRRSPGPGTMRAASPQPQGQYQRSRSPAPGMNMRAASPQPQNQYQRSRSPAPGMPRAASPQPPRQDPYMRSRSPGPGMMQQQQQGGRQYRSASPNPYGGGRPSGQGSNSRQGSGMEMQLSSSDVARYDGSGSGRGRQNMMRPTSSFGGDRYQQGYDGRESRQRGGGGGSMDVELKRERSKSLANIPFRPTQPQVLHYARAMYSYTAAIPEELSFSKGDILGVLRLQDDGWWEAEVRESAKGTRSGGIGLVPSNYLQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BI06</accession>
    <name>A0A0D2BI06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin prenyltransferase PAD1, mitochondrial</fullName>
            <ecNumber evidence="6">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PAD1</name>
        <name evidence="10" type="ORF">PV08_02861</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dimethylallyl phosphate + FMNH2 = prenylated FMNH2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="6"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238789.1">
        <property type="nucleotide sequence ID" value="XM_016377219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BI06"/>
    <dbReference type="STRING" id="91928.A0A0D2BI06"/>
    <dbReference type="GeneID" id="27329944"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02861"/>
    <dbReference type="HOGENOM" id="CLU_074522_1_1_1"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000001">
        <property type="entry name" value="Flavin prenyltransferase UbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004685">
        <property type="entry name" value="PRK06029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Flavoprotein" evidence="9">
        <location>
            <begin position="57"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="245" mass="26932" checksum="FE39794C96EC0DBB" modified="2015-04-29" version="1">MPAMFKSTNSPDTSASEGENDELKNARTTNGSQATSDTDKDTRTSLSTSLRPHARRKRIVVAMTGATGAVLGIKILIALRRLNIESHLIISKWAEATIKYETDYSPKNVRALADHVHSINDMAAPVSSGSFKTDGMVVVPCSMKTLAAISSGYCDDLISRTADVMLKERRKLVLVARETPLSEIHLRNMLSVTQSGAIIFPPVPAYYIKASSVDELSNQTVGRVLDLFDLDTADFERWEGWKRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIK5</accession>
    <name>A0A0D2BIK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_10499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231415.1">
        <property type="nucleotide sequence ID" value="XM_016384813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIK5"/>
    <dbReference type="GeneID" id="27337582"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10499"/>
    <dbReference type="HOGENOM" id="CLU_006937_6_2_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF8">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW11199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="65585" checksum="D801C45D4D7B71A7" modified="2015-04-29" version="1">MGDVDLPLGEQWHSQPRRLRIICVGAGAAGLLLAYKMQKQMRDFDLTIYEKNPEVGGTWYENRYPGCACDVPAHVYTYSFEPNPDWSQFYASGPEIQQYFVRFAEKYHLLPYIRFGTKVQRAEWIEERGCYQIELETNGKRFEDWCHVLINATGNLNKWKWPEIKGLHSFQGTLLHSADWDTSVSYKDKTVAVIGTGSSAIQIVPQIQPKAKRLLTFMRSATWISPPIAADMVVQANANEKAVADAGATDQPITLNHSYTDSEKERFKKHPEEFLAYRKGLEAQFTSQFDLYLTGSKASQEAQRIMQEQMIQRIGPGHEELKKRLIPSWAPGCRRLSPGAGYLEALVRSNVTIVYDEISKIVTNGLVDQNGKLHEVDLIVCATGFDVSFKPSFKVFGVDGADMHQEFDPEPVVYLAMAVPKFPNYFTINGVRGNWATGTALNAQEVCIDYILQCLRRIQTEDIRALEVRREPVLELYERTDRWHQRSVWNQDCKSWYKNNIPGGKLWIWGGSSLHYLKTLEIVRWEHYMFRYNQVNIWGFLGNGKVKAEVERDLAGLTPYIRNRDEPWSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ45</accession>
    <name>A0A0D2BJ45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_02884</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238811.1">
        <property type="nucleotide sequence ID" value="XM_016377241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ45"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ45"/>
    <dbReference type="GeneID" id="27329967"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02884"/>
    <dbReference type="HOGENOM" id="CLU_010365_7_2_1"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="301"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="504"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW18595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="617" mass="69564" checksum="47448CFFC8B961D1" modified="2015-04-29" version="1">MAPWLDLPIMLHSSRDYMCMLNTTEQCAYQQGYWRFWYEADHRYGLPTVAFFLTAIILFYFGHFLSSTLPTGREDKITIWRRITASIRFLSYRGYRLGILGWNSPPLGLLLLGATGVVFFFCMTLGPKPYYWPNTRTLTYGNSPPIATRSGWMALACMPFVFATAAKANMITLLTGVSHEKLQVFHRWISYAMYILALIHTFPFIVFNIWKHDMVEQWNTSVFYWTGVVALLAQSWLVFGSISPLRKRWYEAFKVTHFIAGLTFVVFFFLHCDYTLTSWDYFIATGVLYVVCVLYSQLRTFARHGLGQRANISLATNGLIQVSVPVSFDWTPGQHCFIRFRSMGLHGVTIHPFTICSLPHSPINKPSNPSSTVDFYIRPSGGFTGRLAKHAGGGKSETVMLYGPYGGVNMQRLLECDRLVVIAGGSGAGWTLPFVELQIRHVKRILKAEASSDVAPSLKLIVATRDLTTCKWYLGKVQELLDAYGTTLAEIKSTVEMYFTGAEPLETDSSSPSPPPSTSQFVSKKVDEKDTEMVHPETASDSVDLDALGETHTGRPDLKSMISKEGSREWSQILGVFVCGPLEMQNDVRNAVADQQLDIIRGSVKDVYLHTEHFDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJJ1</accession>
    <name>A0A0D2BJJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239279.1">
        <property type="nucleotide sequence ID" value="XM_016377709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJJ1"/>
    <dbReference type="STRING" id="91928.A0A0D2BJJ1"/>
    <dbReference type="GeneID" id="27330436"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03353"/>
    <dbReference type="HOGENOM" id="CLU_522789_0_0_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23826">
        <property type="entry name" value="UEV_Morgue-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254547" description="UBC core domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="315"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="520" mass="58169" checksum="42B439546804B7AD" modified="2015-04-29" version="1">MEAIGLTVGLLGLAGLFSQCKDLLDLIETGRSYARGLEALDTKFEAQKLRFQIWGEAVGLVGDLTPDENLAHDDVRPVVQRILNNMRLLFDDTHRLKGTFGPRQINDQNAREGFAQLLLRLRRSQEAASLSTKARWSVSRKDKFQTLVEEIRTFMDSLESITSSLEQLSRRRNLLERNIAAAPDEASLRALREVSSESGIVVSDSASSRFLHLDDFNHDPTDSVPDDYSSSHATYVSCRTHPRESMDMGRGDPASITLAPPEIDRQLTPTGSTDDCFSREEVVLQTEKFKTLWQNTGNIALEVVTAGDDSALSGPFPKRIRKEFESVSRGIRDNNMPMSFMTINGSLVDLLGVFMGPASTPYEGGIFFTRWTFTPGYPFTPPLVKFLTKIYHPNIDPRGVICLDILNDSGSSVSLGLEKTLVSIISILDDPTLDDPFVPQIAEQYQARREEYDRTARAYTMRYATGDLPSFEPHDAASPWWQDAENLRNALDEADLTWSRLLLVPCEPQSGQTTKRLARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKL8</accession>
    <name>A0A0D2BKL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239694.1">
        <property type="nucleotide sequence ID" value="XM_016374418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKL8"/>
    <dbReference type="GeneID" id="27327133"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00050"/>
    <dbReference type="HOGENOM" id="CLU_015384_1_1_1"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF8">
        <property type="entry name" value="LD22649P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="67834" checksum="8865E07BB26EB982" modified="2015-04-29" version="1">MSSNSHTGLYPSSNSSTSTLRPRAPRLISYLDDDATDTTSISTSANTHASHPVSRGVSPESHGVPRRSKSVDKGKNPRSGNTYSRPSSEQQTHSGGVGIWESWSSIQGLASTLLGGEPSGSSGSKSNGVIKKPLWMKQDNPYGTRISTPKWGPSHEPSTSAARAAIEERKAMVEAKKREALLLASVSESRDTWGRYKRRDSDVGATDSTSNDASEDALVYLHKVEKGDTLAGVIIKYNCQAEPFRKINRFWPNDNIQTRTHVLVPLAGCTARGRKVDSPYLTNDMFDSRQDYPTSPAADTPQEGQSLSPNLSNSGISSKRDSEALSITTSHAEEIDFKHDSWVLLPNLETPIEVLRVPRRALGFFPRARRKSNATLTDAASNCTPKTSFDMLRHPPTHAARTSGSLGGSPARRPQVKDRGLSGRQRSSSVTSNTFADALRGPGGVGTLRGLRTETSRPGPAEDPLNRNLAKYLPDLLQPEDMPRTGFSLRPSPRATPRPSTDSLRSSRSNSSGLGEVGGAIEGWVRKMAGVKRERGAAIGKMGDLIELETNAELAGVGINGQEGATSIEDTAEMPTPTIPTMTTATTTTSTTTTATTATEEALLNERFPIRGHRVTNAYASTSGPTKDKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL99</accession>
    <name>A0A0D2BL99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232190.1">
        <property type="nucleotide sequence ID" value="XM_016383567.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BL99"/>
    <dbReference type="GeneID" id="27336331"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09248"/>
    <dbReference type="HOGENOM" id="CLU_003000_1_0_1"/>
    <dbReference type="OrthoDB" id="5332281at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="625"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="731"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="784"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="847"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1496"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1534" mass="165229" checksum="9F59F671366D842F" modified="2015-04-29" version="1">MDSNQHPVYLDVPVTDAERAQARRRHDDSSDRLLPEPVHQHPVDTLSWSQYNAPAPSRFPSIRGPPGIRQLPPSISRRFEPRQYAPISPIHEEDEPESIQLQAPSVYNKSDEGSLLRLQHPAPPLWTHIWLKKVTLILFAIFFALLVLALALLWHFDRINDGFHVASGMKHYAWAYAPTVIAVVIVAAWRMVDYHAKLAMPFDALQDGPLKASESLFVDYISKFQLVALFEAIKNNHFAVFTTVVGFILLKVATVFSTGLLVPLPTQVRQSNAPILARGFSSDSFDPNAPLGSLAVASPVYAYYGSKTQGIPPESGVTLDLAYGAITVASNTSVGQNAIITANVAAFVPNMTCSRLDVQLDTPSVVNDTNSAEAFASSSNISFTIQAGEACSRASSVSVPAYNPYTEIVPGRQLTGTMQEIYCGTTIENATDSQGPQGLLFTLTDIKYEQTLFDNATQLAGGTFTIASDVSRTLSNMTNVFCKPSYSMAEVKVINKTQFSDSHQDITIESTDGPNSSLPTFSNWNTTSLFLQSATAADALFGDIVNDDTSSNSSGIFTLMALGEGSQDISSLMDADKMISAAQETYKGVLSQYAHQSLRAAEPSEVDGGTFTKEERRLRVNDASVWTMASIFGFLVIFCIALVFIAPRAVAPRDPSSIAAIATILTRSTELNRLLRKQGVPNFANQQSALSGFEFGTAIAVTDSGTMSFKIVASEGEPTQAATEPNMELKWWLPFTASLPVLFITLALPLVLIAVLEVVQHSSDKHNGLFTVADNKWTEIYSHYIPAIVTLMVASLVNMLDFNVALFAPWANLARGDATSRKSVLHHLLGLLPPWAFLRAIRTRYVGALLSILAAGLASVLTILVSALYTVQHVTVNGPDITLTQLDSFSLQWPNSFSTDNGAAAVVDLIMHQNISYPQFTYEGLVFPKLALNSSEAASGSASIVSGSSSHILPGLRANLRCEVLPSSSFNVSTEQAGGDSAFATNQAFVTATASLPDSCQLGGSSGTGSTVTYENNFELPSGEDGTYAGAQLDLLFGSNASTYGNYGENRGQYIGDNPAVGCPSLAFTFGHFKLGSADQTQVTTMICYQEIQDLKANVTLKDNTTSIDPNNPPTVQSGSVSLRSNPISTTGAKSFDFRIQNNLAQEMTLFNGAEGTPTSDPSATTIFDIYFQAVINGTNKHDPAALVGEDNQDALVDAINQFYRVYMAQSISTNMRTSSSSSSSSSSSSNSSRLFRRQSSTTSTTATTITTSRLVQDKDSKLELQVILGVIVGLCAAAWLTTKMRRVLPCNPCSLAGTMSLLAGSDLCHSVDDGLCECCGKPRRRSFGYDTNSRPESIHAAPDDDDEEDGRQQIIPDGAEWMPQSQFETAFGGQRYSMGWWRERRAVGKRRRFGVDVGERADGADDQDWELGQRRPEGSGFADFMMRGGDRDGRGEYETFGRGRDHIIPDPAAVEGGIPEEREVIARPPRATMPANPNPSCPVHGGVVVGEAVAAASRPRTPNPSCPVHGGLGGDSGPATIARREGSYLGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLC8</accession>
    <name>A0A0D2BLC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239596.1">
        <property type="nucleotide sequence ID" value="XM_016378026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLC8"/>
    <dbReference type="GeneID" id="27330758"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03675"/>
    <dbReference type="HOGENOM" id="CLU_1224798_0_0_1"/>
    <dbReference type="OrthoDB" id="4109707at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24949" checksum="608CB73AD06EADCC" modified="2015-04-29" version="1">MHPATVPDPARLSGSRQWPGERQPTRWDVHDANESPAVTFLDRFRAALLHSEGAEEDSFLDLESVIDSSESLSTSVRSYTYPMVLLSDVPTTPSEDQLARLQDVFYATFKQHIYMKSIDLVGSPSEMLPPYLQYAVACVGSMTSPNVDNVFTTPNGTIQTDAAANLFMAGANLWSVMLEVDNRETRLLEAVVAAILLVTYGVLSSDRTVWRKSSGLFCNVVTVRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BME1</accession>
    <name>A0A0D2BME1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_00334</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239976.1">
        <property type="nucleotide sequence ID" value="XM_016374700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BME1"/>
    <dbReference type="STRING" id="91928.A0A0D2BME1"/>
    <dbReference type="GeneID" id="27327417"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00334"/>
    <dbReference type="HOGENOM" id="CLU_009161_2_1_1"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="69"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="548"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="709"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="506"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="681"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW19760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="761" mass="85903" checksum="E8C79803FAEC7AA0" modified="2015-04-29" version="1">MVKRKLGALEKVDADLANLQNKIKRDPRSYHTDFSHQYIQYENQRQIFMQAPTAASDTGVISFRDLIEFVAHVSDCYKNETKEFPGQLIEILSTHHASLEPELREKIVGSLVLLRKKEIIDSLTLLQCFFPILISTPSKSLRALLFQKIISDLRGANAKSANHKLNKSVQTTLHNLVTEDRTSSRALWAIKITREMWKRQIWTDAKAVEIMKEAAVSDNEKCVVGGVRFFLGGDKEREELEDESSDEEAVDMGRLRHQIGVNKKSKKAERRLEKAAATVRKREKKKGQPHPLNFSALHLLHDPQGFAETLFTKHLQAAKSRLNLEQKLLVLQLVSRLIGLHKLTVLSFYSYFLKYLTPRQPSVTSFLASLAQATHNLVPPDVLEPLVQKIANEFVSEAAAGEVAAAGLNAIREICVRQPLAMNDTLLQDLVMYRKSKDKGVMMAAKGLLGLYRQVGAEMLKKRDRGKDASLGLRSGDQKQQRFGEETVGEIEGLELLERWKEEEKQRKRLEKGLPADGEDDEDEEDEDEEDWNAWDVQEDDSDDSGGWINVESDDEINISDSEDEKPSTKKVRFDAEASTSDDKENEATDEVKEDGVEGPEKTKSNLATTRILTPADLAKLQELRTTSSVSSLMKNHKSHHTSRAEQTNAQRHIDDPLTAAEIEGLASLSRGKATRAQKLALLEEHKADREDHKSKAARKKERKESEGKSTTNKEKARKKNFLMTLGKAKSKGKRSLVEHRKILKAHVARQKKGGKRGNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMV2</accession>
    <name>A0A0D2BMV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232675.1">
        <property type="nucleotide sequence ID" value="XM_016384052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMV2"/>
    <dbReference type="GeneID" id="27336819"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09736"/>
    <dbReference type="HOGENOM" id="CLU_069436_0_0_1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03440">
        <property type="entry name" value="hot_dog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33099" checksum="B0F880067D90F790" modified="2015-04-29" version="1">MPAPDTTPYTGAYTPHLVNTPTRPSRFWRFARSVFWADLFFTIGAIAGTALISWEYLQPPFEAGSEEDEELREEIQETLEAHPLVEGLREQNWTEENFYASRSNGAVRGEHLVGEKLTGTRGVTMKVFKHPSQPITMMVFFLGFGVEGWPDTIHGGMTVSLLHESVHQHLQMHHPELGPATAQFSNVSFFRPMRPGDVYSIFIPPTIVQPSVKAQHKSVHVTPILMYLDGPISVEIESNWQGNFGPGEQPASTQTIAGASTIDRQSLKAIPNVHAFGEMDVAVPEAGAADDNTHNPPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN85</accession>
    <name>A0A0D2BN85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240619.1">
        <property type="nucleotide sequence ID" value="XM_016375343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN85"/>
    <dbReference type="STRING" id="91928.A0A0D2BN85"/>
    <dbReference type="GeneID" id="27328061"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00978"/>
    <dbReference type="HOGENOM" id="CLU_031892_0_1_1"/>
    <dbReference type="OrthoDB" id="5395975at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="279" mass="32252" checksum="203355D705002774" modified="2015-04-29" version="1">MSPSQPLHWQAPTCNNRATVPGFEPAIGFSSPIYPVMGRPDEEISQQTPTRHRHGEGLTNSQPLDRARQPRHRQSFPSQLSDQIHGPNPQGGHARFVTHVTKTLRKLAVRVPLSKHFYPYCVTRDVRVLERGYWEFLVGIIESPTTPDPRQAQQKRRNDEPISLCSGRDFLQLWRNVSRFIKDGKAGWGTSIVRKQVRRGLWRIRLFTWAEILGHIWLVLWVLSDKLIENIPMHWIDGRGTAVVTMSGRKQRRNGRYIWAPKSTEGERGCWGMRKLEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNB9</accession>
    <name>A0A0D2BNB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232835.1">
        <property type="nucleotide sequence ID" value="XM_016384212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNB9"/>
    <dbReference type="STRING" id="91928.A0A0D2BNB9"/>
    <dbReference type="GeneID" id="27336980"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09897"/>
    <dbReference type="HOGENOM" id="CLU_002341_6_1_1"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="258"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="3">
        <location>
            <begin position="554"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="936" mass="106332" checksum="D9189244E66AD7F8" modified="2015-04-29" version="1">MVLDPVSALGAAAAIIQFLDFGCKLLSKQRDLAESSQGTLIEHEELLAVTRRVAELNGQIQNCDISRDNTKKPTQAESALREVSEECRKIAAEFQHVLEGISGRPGQSSFKSFRQAFKIVWHKEGIETMQRRLDQQRSQLILHLLVVISGNQKRDIGSLLDESQRVEISILQAIRDSNAELKSYLVNHLARERTHASRESAQTLSTQKQNALSIVATDITSRIGVDNEEHARNLILDSLYFQQIEERRLRIHPAHEKTCRWVFNKPDEGANTGHNFRTWLEDQLESSGLYWVSGKIGSGKSTLMRFIYEAEETKLAAHVWSKPLPLLTASCFFWLAGTEMQKSRCGLLRSLIHDLLRQAPDLIPIAAPSRWRAATLGSNQQSWTNTELETTLLKLLENGNRDYRFCIFVDGLDEFEGDQRCHSDLVEFLVKLSSCCGVKLCVSSRRYPVFESGFEDFPQLRMERLTRKDIEAFVVDQLGEIKEFGTLEAAYPSTCNDVIKEIVEKAQGVFLWVYLVIRSLKQGLIEGDSMAVLVTRLRELPPDLDELYRRILQSIPSHQRHYAAACFQIVLGYSGLTIPRMSLMTLWFLEEETLDFAAATPVEPLAKDIIRSRHLMLIRRVEGRCRGLLEVFELGDKDTPAEYSVDYLHRSVRDFLMSRSAQRLLALHLEFTFDTRRYLCQAFFAQLKMSFPPNHPESSDDKSLERSRAVFYGLFLSQLREWTASPSTLQPEVFQAMVSLINDYGYLFMPDDIGSMKRLFRDLIDSGDETHVMELIPKHNEVDLDLSLQLFDLIGTSVIRGRADMYYRVIIALLENGANPNQKESYLRILSTTPWTGFLKLECDPNYKGRHPSSLTRPGGQPQSEDGRQQAFLAARAFIEHGAAIRTPSGQSCLKLIHKAFPGSDGDELVSLLEAKSRPKSRFHRATQKLLGRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNY9</accession>
    <name>A0A0D2BNY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_01193</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240834.1">
        <property type="nucleotide sequence ID" value="XM_016375558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNY9"/>
    <dbReference type="STRING" id="91928.A0A0D2BNY9"/>
    <dbReference type="GeneID" id="27328276"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01193"/>
    <dbReference type="HOGENOM" id="CLU_011476_0_0_1"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000151">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase btgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="182"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW20618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="738" mass="80002" checksum="C386F4EE4D00F10A" modified="2015-04-29" version="1">MSTGRTFSFEHNDDQNDLQMQGQDYQPYQPHAFEDSLTRTITSPPPEYTPSSPQRVPAPSSPSTSPRRRPIPQDTHLLNDSSPTRTQYQEADFDDLPAPPPPPHRSSPTRLSRDNPGYSQPYRPYSDVTTGADNYGDQVVGGGMNTIARGVADTHPRESGIEAMRSVPQSYTPYSSAYGRDPSPSLQELPPSQLPSRNSYGSSFALAAGAATPPSGSPGPRSSAFSGRSIPLDDYGGGHNRPMSYLGYQDSPYQTPYNPSLSSANIMNQAHINPNNILDDGDEEFSHAQQMDNRPNGADSSGPAAAAAGAGTVGVLGGLFGRRAKNVTSSGSYDPVGNGTKAEKSDWLAQQTQGKRKMRRWVGIGIGLFVVLAIVGAIVGGVLGTRNSDGDSSSSGDTNNASTDTANNGDLSKDSPEIQALMNNKDLHKVFPGMDYTPWGTQYPLCHTYPPSQNNVTRDMAVLSQLTNVVRLYGTDCNQTEMVLHAIDRLGLTDMKLWMGVWIDTNQTTTDRQMDQMYKILANTKDHSIFKGVIIGNEALYRAGEDKSQSEQELIDILTDARSKFKSNGYDLPIATSDLGDNWNAQLVQVVDYVMSNIHPFFAGVTAEVAAGWTYDFWQTHDVILTESLPNVKQLISETGWPSGGGTDCGGTDGDCSPGQSGSVAGVDGMNTFMNDWVCQALSNGTDYFWFEAFDEPWKVVYNTPGKEWEDKWGLMDPGRKLKAGLKIPDCDGKTVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPY1</accession>
    <name>A0A0D2BPY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1348-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_01130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240771.1">
        <property type="nucleotide sequence ID" value="XM_016375495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPY1"/>
    <dbReference type="STRING" id="91928.A0A0D2BPY1"/>
    <dbReference type="GeneID" id="27328213"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01130"/>
    <dbReference type="HOGENOM" id="CLU_112790_1_0_1"/>
    <dbReference type="OrthoDB" id="14527at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757:SF0">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW20555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19937" checksum="855231B348FE9B8F" modified="2015-04-29" version="1">MASLKPPFTLATAREKVKFAQNMWNSCNPKQVSNGYTANCVWRNRDQFFVGTEKIVEFLTKKWEKEASYRLRKELFAFTDDKIAVQFWYEYQDRHDGMKWKRTYGLEDWTFDRETGKMRKRQMSANDILLGRDGDGVAVPDEGIQGRWYVDGVDVDDESVTQKITEAHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQG7</accession>
    <name>A0A0D2BQG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_01798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241434.1">
        <property type="nucleotide sequence ID" value="XM_016376158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQG7"/>
    <dbReference type="GeneID" id="27328881"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01798"/>
    <dbReference type="HOGENOM" id="CLU_2831210_0_0_1"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW21218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7594" checksum="6922D1AB2CAD42C1" modified="2015-04-29" version="1">MDLLDKKSLKTTRGLSYAYYVLKDHPTSSALPTILFLRGFPDSSSLWFGIIERIAHLQYPIMAIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQZ6</accession>
    <name>A0A0D2BQZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233825.1">
        <property type="nucleotide sequence ID" value="XM_016383122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQZ6"/>
    <dbReference type="STRING" id="91928.A0A0D2BQZ6"/>
    <dbReference type="GeneID" id="27335882"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08799"/>
    <dbReference type="HOGENOM" id="CLU_312157_0_0_1"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="165"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="948" mass="107999" checksum="C129F9487E2745D9" modified="2015-04-29" version="1">MTSSGDILHTDPPSSGERPSYSERFKETFKEHIRKNLIGETYLPAGMLSGVLSQETIKNILLETELERSQVNELSQSILPGAVKVFTILLLIGRLERILYFIEDDQLQPSTLDQKLPLPLEKVLSHLDDEVAAAQFYKQQWAFTAPVFSRSSLPRVLEKKTVMPFIDSKSEGEGGFGEVHRILIDPSHHTFAHSSRHWFIRKELKADVATQHDYELELRNLSTLRLMKHPYLVDLLACFTYRDRYNFIFPLAIGGSLADMFLGRRPSPFEAFEETFLAFSGIVSAVRAVHDGFADGVEVIGCHRDLKPSNILLNGKTMLLADFGLSRFKQPEEGSASYFRAGRGDYLAPECEDLDGLFKKHVIHRSSDIWSLGCILSELLVFMLAGTSGIEMFRSSREFKRDGCVYYRFHQGRDTLNPGVWDHLKAFQSSGTEHARSVLSVVEKLLVLNPEERPRISVVDAYLRRFCIETLSEQITDMYGQLCEEKSLIPALVEMQRFRSWHMEVRDTNHASASSFLSAKTHEAFANVMESLKELRQTLNVIIIEPKPRQSQTYLLLRKINDVLYDALPEEWVESGKTRFECLMLQSEDTAHLFELSEALARNSIQAVGRISQLAAVKRLNLLVDMHKQNSNSCINRLDFDDIEKKGWLEQNYLGWVKQAKGNPIKQSVIIELKNYDDHYSIAEIASQLFARLEAVVSLLNAAQYLRVLPCLGYYHDPSSYSLGLVYKCPIAHETGKSTVNTLHAILEKAVEKRGSKRPSLGHRFQLACSLASSVLEFHKVGWVQKAVSALNIIFFKPSDASWKRHMTEPYFLGYLNSREDGKGVFTEGPTDDERLRRYLSPEYLHNQRYKHHFDYYSLGLVLLEVGHWRTLDNIVGDLGKSPEELRAWLLNVAVPKLDQMMGSIYERVVGNCLRWQPEFEGQEKGIPSAECLRFSELVVGELALCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRN7</accession>
    <name>A0A0D2BRN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_06680</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234115.1">
        <property type="nucleotide sequence ID" value="XM_016381013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRN7"/>
    <dbReference type="STRING" id="91928.A0A0D2BRN7"/>
    <dbReference type="GeneID" id="27333763"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06680"/>
    <dbReference type="HOGENOM" id="CLU_026207_2_0_1"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000009">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="160"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW13899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="433" mass="47345" checksum="9B6AE709BE14B78E" modified="2015-04-29" version="1">MGASSWLDIPKGTHFSLANIPFGIVTTPRSGDERHAAVAIGSLVLDLHEFANHQGFVGLEDFTPSQIATFSSPALNDFAALGQEVHRRVRRYLQDIFAEKTSFPALLKDNVEAQNACLFQQDQVEMHLPMKIGGYTDFFVGKNHAYNCGCIFRDPAKALQPNYLHLPVAYNSRASSVVVSGTDVHRPLGQFLQPPDTLPSFGPCRKLDIELELGALLCKGNDLGEPIDVNEAEKHIFGFVILNDWSARDIQQWEAVPLGPFNAKTFASTISPWVILKDALEPFHVEGIPNETKLHPYLQETREQNVYDVNLEVELRAPNGESAILSRTNGRNLVFSFAQMLAHHTVGGCPLEVGDLVGSGTISGPEPGTLGSLLEASNGGKNSYDLSATIRRTFLEDGDSVVIRGWCGDDDSNIVGFGECSGTILPSIKRSWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVB1</accession>
    <name>A0A0D2BVB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235420.1">
        <property type="nucleotide sequence ID" value="XM_016379593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVB1"/>
    <dbReference type="STRING" id="91928.A0A0D2BVB1"/>
    <dbReference type="GeneID" id="27332332"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05249"/>
    <dbReference type="HOGENOM" id="CLU_085418_2_0_1"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="237" mass="24900" checksum="A126C418F7911D59" modified="2015-04-29" version="1">MSTQNAQQPSQSTSAARPPVTVGQTTHLDPGAYVRGTHAITLGEHILIHPRSQLIGVHGPLSIGDKCIISEKAIIGGPVQPSSTTASSAKPSGGSVQPSPLIAQGAEDDDTDRDPVKTTIGSNVFIHASSQIHAGAVIEDAVLIEPHVSVLAGVTVGSHAKLCAGVTVDHDVDEWTVVYGKGNIKRRRKQNDPDSDEGAEQAEAIETMRLKAMDKEREGTTTILKMAARVATMAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWM5</accession>
    <name>A0A0D2BWM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235905.1">
        <property type="nucleotide sequence ID" value="XM_016380078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWM5"/>
    <dbReference type="STRING" id="91928.A0A0D2BWM5"/>
    <dbReference type="GeneID" id="27332822"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05739"/>
    <dbReference type="HOGENOM" id="CLU_000288_77_1_1"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="248"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="671" mass="72636" checksum="5CF0C9E572F7D9FD" modified="2015-04-29" version="1">MANVFDDQGDTGFRRRRPRPITDYGSSIIQWMHNRKPPYRGSYHYEQERPSLSYVLDILPPPAKRDSPAESIPVRHLHTSLGKSKKPVTVVRWMPEGRRLLAGVHNGEFMLWNGMSFNFETVTAMGSSSLRAAEWSNRKDWLVAANDEGTVYYLQATLNNPHQFKGHDAPIRDIAFAPGDTKFVTASDDNTCKIWDFTSSAVESVFKDHGWDVKACDWHPTKALIVSGSKDHSVRLWDPRTSRSLTTLHGHKNALTATVFSRLRDQLLASSSRDGQTRIFDLRMMRDVAILRGHEKGVTSVSWHPIHPSLISTGGDEGSLHTYLLTEPNTPQGVSSTVISPYTSSDQRSVPAQSIYPAHRIPHAHDSSIWSLDWHPLGHILATGSNDHFTRFWSRAQPGETTCFKDKFHLGEEGAEAQGTWDRKFGQRQAKEQEEQEAEDEAEGLEDQAVSGTQSAAAGFSIPGLPGLGALGNGSTPSLPGIGATNIPPPPINLLPGLPNQLGVAPHGHPIPQIPGVDASSLQRLLAMSQQQQPPASFQQSQQQPPPPPPPPPPGLGMGMGMSMSQQQQQPPAIDFSQLNLPLGFPPPPPPPGQLPPGLSGLGGTPPISISGIPGLGGGGPPALSHQGGGGNGTNSSTPGNADGVRRRAPLPSQRDGFKAEQARGNYRVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BY02</accession>
    <name>A0A0D2BY02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236395.1">
        <property type="nucleotide sequence ID" value="XM_016380568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BY02"/>
    <dbReference type="STRING" id="91928.A0A0D2BY02"/>
    <dbReference type="GeneID" id="27333313"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06230"/>
    <dbReference type="HOGENOM" id="CLU_037966_2_0_1"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF17">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250228" description="ribonuclease T2" evidence="7">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="323" mass="35636" checksum="74988A9EB45B0917" modified="2015-04-29" version="1">MAFKHAALAAALLTSVTQASLYNESKLNHTCVLEPSILSCSAAANPLTVDSCCTETYGGLLLSTQFWSTFTGLEAKGQLLPKNTWTLHGLWPDFCNGSYTQYCDLSRQYDPTPSPNTTNGLRNGTAVPAYKGPSIDTFLAPFGKDDLLAWMNTYWINQGAPNSDFWAHEFSKHATCYSTFDVPCYGPEYRQHEEVVDFFETAIKFYRRLPTYDWLASAKITPSNSTQYTLADIQSQLAKKYGATPYIGCSGPRYNTTAAGKNGTDSGRTVVSEVWYYSHVVGRPQDGNSIPVNATTPNSSCAKAKDALWYYEMTPGSVRPEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C1M8</accession>
    <name>A0A0D2C1M8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha 1,4-glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016379098.1"/>
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    <dbReference type="GeneID" id="27331836"/>
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    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF23">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43895" checksum="5303D8F116D13C30" modified="2015-04-29" version="1">MEAGAAPRNINPLHQYSRSRKPLRWAICIVLGTLAILALTGQSYGPDPIRRTSSGAKAKYLTPAKLMERPISKDLQTVPKLFHQSWSSNELPAKFQRWSTSCRQQHPDWEYILWTDEDNEKLVATHFPWLLSTYQALPGVIYKADLARNLYMYMFGGVYADLDVECLRPSDELFKRYNVSTVSHAKPRPMSTYNLQKNGRKAFFGRMGVDTEEANSIPNAWMASTPGHPFFLIVLEHVMRTMHEGTSDEGPEDTTGPALLFNKINEYLAEDGKFRGENMDKWVSKNPTAKQFTPRRGLGHSVEVLPFQYIFPYSWQRDGEAVRDVCWATRRSFSAERCKLLLATDHWPSYAITYWSHTWAGEGHDEGNVDHLNFDEEKEQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C2P0</accession>
    <name>A0A0D2C2P0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05089</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238110.1">
        <property type="nucleotide sequence ID" value="XM_016379433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C2P0"/>
    <dbReference type="STRING" id="91928.A0A0D2C2P0"/>
    <dbReference type="GeneID" id="27332172"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05089"/>
    <dbReference type="HOGENOM" id="CLU_002116_1_0_1"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="666"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="846"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1086"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1128" mass="125050" checksum="C09A67E364539E94" modified="2015-04-29" version="1">MFVAPLRIHRNSSDNLPGALYNEPSPTATLASDTIDDSASSHARFHNYLRALYTFQPSPHSSTTVTLPLNAGDLILVHSVHVNGWADGTLLETGARGWLPTNYCESYDHAAMRPLLKALTEFWDIVRCGSDSNLNLFRNQDYMRGLVAGVRALLERSECLTRDATLVRQHDGIRRSRKSLLSDLALLVRTAKQLQQVVTVSSSHKDLDIRLDDMLLKAFRIVTRAVSFFDVWSEQIVAIVSAPTRSEVSRVEPSGPPTSPRSRRPHSTILLRDSNPTASMSSAPSRRSSAGPVAHNTPVRRRSSTTHRMSYTRATSQKNSNLISQYLHQSYDDFLTVLASFLGSHMQSRSSSELLMTTQNAVRSCRQLFAIVETVIDRDYSTSRPLVQAKDAMYYAITELVHAARQVFKPIHSMDDELVYLPEEAQNLVRAATACVSAAGRCVARTKATLEEIGDFEIENIAQLVGRGSDSSSTLESTSQGVRSSVNLRSPTQSAAIEDSSRRLTENVPVSVPRRMITPPLSRNTAEGPLTSFATVSPPPRDDVIVDIIRSSPVPPQAPSLHPDSRIRAPGINQPPVDKRKRTSAVLPMVGSKGSDSSLDTTHRRSDPSNLSTASTRVTSMYGGGSVTGPLSAQFPPDDHSSLGDDDDAEAEIMANTFAQELIFNPEGVVVGGTLNALVERLTAHDSTPDASFVSTIYLTFRLFARPEEFASALAVRFDYVAENPRITSPVRLRVYNVLKGWMESHWRHDCDDTALPVIVGFARESMVPVLPMAGNRILELADQVSSSNKPLVPRVVSAMGKTTTSSATYIDPSTPFPNPVMSKSQLSALKTWRMGGATVSILDFDPLELARQITLKTSKIFCSILPEELLGTEWTKRSSSLAVNVRAMSTLSTDISLLVFDSILQLEEPKRRAAIVKQWVKIANKCLELRNYDTLMAIVCALDSTNIKRLRKTWEGVPQKTKSVFDELCKVIDVSKNYSTLRQRVQSHLPPCLPFIGVYLTDLTMVDTAYPGTRSLTTDQGKITVINLDKHMNTAKIISDLQRFQVPYRLAEISELQTWMQDQLVRVRSAGDKSFQMHYRRSLILEPREPNKSPNPDMPQSAKDKDKFDLFNWTHLLQKEKPVPIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C943</accession>
    <name>A0A0D2C943_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_00639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240280.1">
        <property type="nucleotide sequence ID" value="XM_016375004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C943"/>
    <dbReference type="STRING" id="91928.A0A0D2C943"/>
    <dbReference type="GeneID" id="27327722"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00639"/>
    <dbReference type="HOGENOM" id="CLU_079104_0_0_1"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239628" description="NmrA-like domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="316" mass="34867" checksum="A5728BF00CD4A8D8" modified="2015-04-29" version="1">MLILIAGVSGLLGKILARTGLEKGHRIRGFGRSPSKIPAELLDKFESFVECEYYEDRLALDKAVSGVDAVICSYTAHAEAILDSQLALLRAVERAGVKVYHAHSWNPDWSRTSLGDWEHYDAYISFRRHVELTSTLKPVYTFTGIIGEYAVSKIVGIAHVEDDADTDTDGNGGRKTVAYYGDGTAKWDFTYLDDAARFSIDLITTNPSVLAGEGGIFRIHSAAASALDVARAYEENTGQGVALRSLGTAEHLLQKYREARAATRDPRQYFVYGPYYVHAANIMGLWRLDNPVEVGSVDAVNRLFDRQIDIAADLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCQ7</accession>
    <name>A0A0D2CCQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_01864</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241500.1">
        <property type="nucleotide sequence ID" value="XM_016376224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCQ7"/>
    <dbReference type="STRING" id="91928.A0A0D2CCQ7"/>
    <dbReference type="GeneID" id="27328947"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01864"/>
    <dbReference type="HOGENOM" id="CLU_011398_4_5_1"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="10">
        <location>
            <begin position="518"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="461"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW21284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="602" mass="65551" checksum="D2558B108972EEE2" modified="2015-04-29" version="1">MTDFFGGNSTKATSGINGALTRTQVDLGIQDSVKQFYEDTLKSARDKARPDLIRVLTYQSAAAVEWLQDVFNLDLTLVSRLGGHSFPRTHRGHDAKFPGMAITYALMQRLEELCESDPERVQVIKKAKVTSLNKEGNLITGLKYEFGGETHSVDGVVVLATGGYAADFTETSLLKKHRPDTFHLSSTNGTHATGDGHKMLMAIGANDIDMDKVQVHPTGLVDPKDPGSKWKFLAAEALRGEGGILLNSDGKRFCDDLGHRDYVSGKMWEEKEKGKWPIRLVLNSKASNVLDFHTRHYSGRGLMKKMTGKELAKEIGCGEAALDAEFKSYNDIAAGKKKDIWNKKYFHNMPLDINDTFHVALMEPVLHFTMGGMEINDKAQVLNQEKKPFEALFACGELAGGVHGANRLGGSSLLGCVVYGRVAGASASQYLFQKLTAGGATGASQRLGQISLHIDPSTPGKVSVEWGSGASGAAASAGSAPIEQQSQKSAAPVLDGNKSQDPAKKKDTNDVSNFKVPDKEYSLEEVAKHNKKDDLWIAVKGVVMDVTNWLDEHPGGPQALFSHMGKDASEEFEMLHDDEVIPKYAADIVIGRVKGQEVRLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y4H0</accession>
    <name>A0A0D1Y4H0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230057.1">
        <property type="nucleotide sequence ID" value="XM_016386249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y4H0"/>
    <dbReference type="GeneID" id="27339025"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11942"/>
    <dbReference type="HOGENOM" id="CLU_022883_1_0_1"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="437" mass="50165" checksum="AEBDDD6E215256E5" modified="2015-04-29" version="1">MASPNGSASSSSTQFVRGWVSQPDGRGTWDIIQQCVATLALCSWSSQVLNIFPGEGRVSFMKWKLRWVLFTLFWPEITLGVAYEQWESASQSVEDFSKISKKGYETWTMRHAFFAEMGGFQLQTPDFPVFAVDSQQILYLIKNNYITYPNVDVETIWDKNKADGFARAITLIQIAWFSIQCIGRGIQHLSLTALELLTINMIFCTLFTFYFWYHKPLDVQTPIVLPSDTTIAEILVKAGDPAREPYKLTPLDFIASRPTPANFVAAWWWGLRLCFDGKLFEMDKGPRPATTFSHSRSLPPRGYSFWSCLCRILISSAYFALHFAGWNFTLPTTLEQKLWHTAMIYFVGLYCTYLAVFTVVTLLSGWIASKYFQKEARTFIEVASMFPQWFQLCGLLPIYGSYGVMRAYLVIESFISLRMLPMDAYDTVNWSDFIFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YAQ2</accession>
    <name>A0A0D1YAQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA (cytosine-5)-methyltransferase 1 replication foci domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232207.1">
        <property type="nucleotide sequence ID" value="XM_016383584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YAQ2"/>
    <dbReference type="STRING" id="91928.A0A0D1YAQ2"/>
    <dbReference type="GeneID" id="27336348"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09265"/>
    <dbReference type="HOGENOM" id="CLU_565021_0_0_1"/>
    <dbReference type="OrthoDB" id="5382953at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="58046" checksum="6FBDBA614C89394A" modified="2015-04-29" version="1">MSTLPEERVLKPLDPVPEDVNEWPDFALRDVKVFYQGKGRYADLLHASEETPLCVVGELMPLDDEHDHLVLIENPLYARIKIDNVTNFSFGQDDDGKPVIWAAGKAGWYEISPSDRYLSHYNDTVEAIDLFYFMVDQHQRLPKTRQRFGFRIDPFLKDYQKHTGYRIDDDDEAMETIHKHHRFLLKQMIEEREGIDWSQTYLWNHLAETYADEVEELQTTLSRLTQATAVEEPEMGGGGDDGDDESEQDSSSESEESGSEQQSKADSGDDRSTSTEVKPPPIDWTRPIWEMLNILRKSANFNMRHCGIDEAATELEKLPAFEGTHEDAVAAFEHSAEELLRLMNEAKLRKKFNWSTRRIYDELEATLADEVADETMKTPGKSAKQRHRMKSVLRPSGAIKSHKRARAADTVDEDEEMSDIPVSSSMVARRQAPPLHSRLRETTADSARSREDSPSRQLNGHYDPDALPELPPVPEAQELLDLVAEEARRVGRQYQVGHLQSFLGQWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YAV2</accession>
    <name>A0A0D1YAV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232242.1">
        <property type="nucleotide sequence ID" value="XM_016383619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YAV2"/>
    <dbReference type="STRING" id="91928.A0A0D1YAV2"/>
    <dbReference type="GeneID" id="27336383"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09300"/>
    <dbReference type="HOGENOM" id="CLU_076387_0_0_1"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="235" mass="26292" checksum="EC5C03B82977C3E2" modified="2015-04-29" version="1">MSQILVPRVSACCWRSLFAEIQPQRQWSRSLVTLQRGPVEKLAIPESLPPQFRSQIPPRLRPGRDKRDITVHESPVSEAALCKDPVSLIDQRQLALLDPTGARARLFDKTNKDRAQVGDILLVTFKTGEPVSGTILSIKGSGPHISVLLRNQLTGIGVEVLVKVHSPLVQSMEIAQRAPKRKRRARLYYLRKPEHDPGSVQKIVDQYVRQRAMLSGGGKTTRQQHTGPRGKKGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YFD5</accession>
    <name>A0A0D1YFD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234017.1">
        <property type="nucleotide sequence ID" value="XM_016383314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YFD5"/>
    <dbReference type="STRING" id="91928.A0A0D1YFD5"/>
    <dbReference type="GeneID" id="27336076"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08993"/>
    <dbReference type="HOGENOM" id="CLU_057148_0_0_1"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="284" mass="30978" checksum="9D04955DF3010B14" modified="2015-04-29" version="1">MTRNGPTHNYKQGYSNQTVATQQTRTAETEASFLLPHIKKTDYILDVGCGPGTITTGFVKYASEGRTIGVDISPSVLGRAKAVAEEARIPDDGPGSIAFEEGNILEGIPYPDNTFDVVFCAHTMGYMPPPDMPVKALTEMRRVLKPGGILATRDAVEQHFYPRSTDLDRLWVGNFRRAVLNGRSTEDLAPPAMPALFRRAGFDADGGKVLVGCGSSAVSGAPARQFLAKRAQSQLQVGDPLYKSWREAGITEDEIQETLAASKRWADTEDAWYAAMSCEMLAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YI02</accession>
    <name>A0A0D1YI02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234742.1">
        <property type="nucleotide sequence ID" value="XM_016381640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YI02"/>
    <dbReference type="STRING" id="91928.A0A0D1YI02"/>
    <dbReference type="GeneID" id="27334393"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07310"/>
    <dbReference type="HOGENOM" id="CLU_029658_0_1_1"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000270">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="271" mass="30379" checksum="D9897C71C69E2F9F" modified="2015-04-29" version="1">MARKRKSVNYGHESEQPPAKKVASTEPLPEGVHHYETLEEVPWDLQKYWHQGYSIFSKYDDGIWMTDDAWFGVTHESVANTIAKHMGEATNKSIIVDAFCGVGGNTIAFALSGKWKRVYAIEKDAATLACAKHNAEIYGVADKITWFHGDCFEILGAMEGRTEKTVDALKAIIGQFGVIFASPPWGGPSYRNAEVFDLESMEPYTFSHLYRSFRKVTSDVVLYLPRTSDLRQVAKVVQEDKKVQVVHYCTHGTSRALCTYLGNWASLKLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YI86</accession>
    <name>A0A0D1YI86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_07435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234867.1">
        <property type="nucleotide sequence ID" value="XM_016381765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YI86"/>
    <dbReference type="STRING" id="91928.A0A0D1YI86"/>
    <dbReference type="GeneID" id="27334518"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07435"/>
    <dbReference type="HOGENOM" id="CLU_019472_2_0_1"/>
    <dbReference type="OrthoDB" id="4117572at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000007">
        <property type="entry name" value="p53-like transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF1">
        <property type="entry name" value="PROTEIN PACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="92"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="92"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW14651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="635" mass="69656" checksum="D3374F97A44E4538" modified="2015-04-29" version="1">MAVTMDGFDPLAMPYLHSPMPFTDGNLQNLDYMSVPSVMDLQDQYSNFDSEPYMSGDDMNFAPSSSMQPSAMLKRFSSGYDDPFAESTMSQFDQVPQEGLPESPSIDRDSKYLSFSMPQYNFTLLDDSFRRSSVNINAQLHGMFFLAESQWPATPDAPPPPPELTCYRRNLFQITGNVTLPRNLRYVFTDDGSRIPIYELELSVSATESVEGNPVKIISVPWKTPASGEAPKPEDKIEKEPPTIPLDKMSGQDIDTDFTTFPIQWKRLQFRIATANNGRRKELQQHFTLHLKILASLSTGSKIPIAESHSGAVIVRGRSPRNFAARKDLPLSSSSTARKHLPSASRAGNSQTSVPQVTSAPKIRTPPNDMPPSSTVGYDNNTNTDFKPTPDLDTGNWLSQMAASEPLPTPYSVSMNPPLVPTFSHDSTPELGTPGAFPFTFTPDMGAGNSGAMSLHFGSDDEGGNGGSSPYHHQPGSRHSSRPPTSNPSPSLVNKPGAGTTPPAHLQHPHHSHTRQRMHGHQVSVTSVPNSSALPTSNTHIMGQQPQPQPQHQQSLPHQGGVPRPDLGLTKSLSFHNEGESADQLYEYFPLGLDDWMPPVDAVFRPHVVHHSGPLPPDPRSPGRHTSKRYFSEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJ03</accession>
    <name>A0A0D1YJ03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235132.1">
        <property type="nucleotide sequence ID" value="XM_016382030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJ03"/>
    <dbReference type="STRING" id="91928.A0A0D1YJ03"/>
    <dbReference type="GeneID" id="27334784"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07701"/>
    <dbReference type="HOGENOM" id="CLU_011409_3_0_1"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="660" mass="73571" checksum="37D677DA4A10D667" modified="2015-04-29" version="1">MTERTISRLSSSRPTTAPIARKVKTGCGTCKIRKVKCDETYPACRRCLQTGRVCDGYGIWGGGNRPAVPARATEQLDSGGTLWRSEQYVQGLRKLQPGLRGNDPRVTGEHTEVDDHVSLVSIKGTSVNSPANLRLVPIHVVPTDQHGYMEWYICRTAPKLPGAFRESFWDRLLPQASQSEPAILHAILSLASIHKRALLDLVPCSVRNAKEIGSLFTLQQLTLATGTLRDRIANRSQASLRVALIACAVFIVLEYMQDNYQTGLTHLRHGLILLEEFMLHDGQSNGDANDDSIINTFVTLLIQARLLGQDIYHPSLLPLLIDKLDVRCWEFQSAADARRCLEWIFLQTFSIADQTGCNLFCDRLSSSITVQPNQMMDIHQYLRLWQGAYETSMMRFRSMLSLMDFYSWKLLLLLHTLACVLVQDFAPTVYEQVVDSSATESSTRPPDTSSRDASSAAFSTVPTLLASHVPSSHSGSRTEYSSGIGLPRDPCLSIISQCSWIYREVRDPVPVLYDTNSLGINETAASSIADIGWMPALFYTAILARDSTTRREAANLLYLRPHREGIWESYLSGILAEKIIHTKEEKRNTQPPSNSSMNLEGDLGHALETSTLRDIRIQLPSSSDAKLVLTYARLLGDVAGAESWNNERCIYDMRAGCWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YM05</accession>
    <name>A0A0D1YM05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236232.1">
        <property type="nucleotide sequence ID" value="XM_016380405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YM05"/>
    <dbReference type="STRING" id="91928.A0A0D1YM05"/>
    <dbReference type="GeneID" id="27333150"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06067"/>
    <dbReference type="HOGENOM" id="CLU_021861_1_0_1"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF70">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="194"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="536" mass="59051" checksum="5A4AD6FAECA5F08B" modified="2015-04-29" version="1">MQVLMTMPPEQQESQPPGYDQNGWMSVHSSYSPSPQASVSPLHELSSFDYHTPNPMPLEPAYNMHRPSPFAASHPQMLPPLMTAHTGLWPSMLASQQPPSSYHTPVQTPGSLQTPLSASTASDVTPTSAKTNPTRRKLTDEERRQMCIEAEQNPTMKQTQIGAKFNVERSTVSKILRQRDRYMNPQFKEESTSPIVKKSKAKLPDFEKTLTNWVKKQQVKGLPIKDEDLRKQVQVFSFSRSDQAVVSGAAWLEAFKRKNNLITSQSADGEPTLIDSSTTSLSHTPADESPPSSHGLVSPAMSTLEELRLKREETHEFFDFDTGKGSYGHSPSLEHNLEEPALGDVLSPITPELVQEDPDGITMMEAIPDIRGNSSRQRSQTFSHVPGIGSDSRPSPSSNEASSLPVRSLTSPGDGELSGIDPRQTMKRHKSVPDIHYPEQARFSPMPPPPLPKSADTSPVSHPASPAEDDNIRALHTIKALLEQHPNLAEPDDYLAIGKLMQKLKLLRSPANTLLPGGMMDSPRISKKRTILGIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YM82</accession>
    <name>A0A0D1YM82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236337.1">
        <property type="nucleotide sequence ID" value="XM_016380510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YM82"/>
    <dbReference type="STRING" id="91928.A0A0D1YM82"/>
    <dbReference type="GeneID" id="27333255"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06172"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="335" mass="36289" checksum="C503CB6D8CF0D7C1" modified="2015-04-29" version="1">MATMRAVDIKGGKGGIDALFINAETPKPTPKGSQALVKVKYFGLNRMDLLQREGYYPVPPQAGPIMGVEFSGVIESFGSAPERGFNVGDEVFGLAYGGAYAEYIAVSTHMLVHKPKELSWEEAAGIPETWITATQALYLVGEFKPGMSVLWHAGASSVSIAGIQLAKADGASAVYVTASTQEKIDFCKTLGATEGFSYKEGNWAEALLKYTDGKGVGLIVDFIGAGYFNQNLDAAAQDGHIVLLGMMGGGVVKGDVDVSRLLRKRLRIEGSTLRSRDEKYQGRLRDMLVEHALPRFVKGEFKVPVQKVFKMEEIKEAHALLESNQTMGKVICKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMH4</accession>
    <name>A0A0D1YMH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236452.1">
        <property type="nucleotide sequence ID" value="XM_016380625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMH4"/>
    <dbReference type="STRING" id="91928.A0A0D1YMH4"/>
    <dbReference type="GeneID" id="27333370"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06287"/>
    <dbReference type="HOGENOM" id="CLU_023062_3_3_1"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="586" mass="60335" checksum="220CC350B4516568" modified="2015-04-29" version="1">MSRRAPADRAAQNAQTLKALVKLEGNKICADCKRNKHPRWASWNLGVFICIRCSGIHRGMGTHISRVKSVDLDAWTDEQLQSILKWGNSRANKYWESKLAPGHVPSEAKIENFIRTKYESKRWVMDGPIPDPSTLDDGEDDMPLNIVQEKAKIERSASQRATATQPRPPQPRAAPNVDLFDDFAPPPPARPSTADFADSRPTKTAPPAPAPAQAAKPAGKPQDSLLGLDFFGNAPSGIGRPSSAAANPTSSANSRGDLKSSILSLYASAPKPQPAQTQHDRQPSMGGAASPPLGNQGAFGGLADAFGGLSFSSTTTSPPPQPQSSSAFSAFSGLTSTGPKPTPSVGASPPPPLSGGSFFDSVPSKAPAVKPTVTSTSASNGLDFAFTQTASAPQPAAGPAPSTSSLPVDLFAADDFGGFASSMPASPPKPASTSVASAPTSTANTGSPFNLSSSTSSAPMPAPQQAPQTFKSPAAPQNNAALFDPWGSGNDSSPWGAPDQAPAPPAQPKVELGKPPAHITANDIRGGWAAPMSSSNKPSQQPTVTADEDFGGWTSAPTTQTPFSGPAKPSGGGFGGASDPFDNPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNK7</accession>
    <name>A0A0D1YNK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome-interacting GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236897.1">
        <property type="nucleotide sequence ID" value="XM_016378220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNK7"/>
    <dbReference type="STRING" id="91928.A0A0D1YNK7"/>
    <dbReference type="GeneID" id="27330952"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03869"/>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="65"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="292"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41116" checksum="F82473DD871C5865" modified="2015-04-29" version="1">MVNITEKIKEIEAEMARTQKNKATEYHLGLLKGKLARLRAQLLEPGPGAGSGGGTGFDVSKSGDARIALVGFPSVGKSTFLSKITKTKSEVAAYSFTTLTAIPGVLEYGGAEIQILDLPGIIEGASEGKGRGRQVISAAKTSDLILMVLDATKRAEQRALLEAELEAVGIRLNRDPPNIYLKAKKAGGMKITFQSPPKYIDEKMVYNILRDYKILNCEVLVRDENVTVDDFIDVIMKDHRKYIRCLYVYNKIDSVTVDYLDALAHEPNTVVMSCELDLGIEDVVERCWQELRLMRIYTKRQGVEPDFGEALIVRSNSTIEDVCDQIHRTLKETFKYALVWGASAKHIPQRVGLAHVVSDEDVVQVVSAWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPI2</accession>
    <name>A0A0D1YPI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237307.1">
        <property type="nucleotide sequence ID" value="XM_016378630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPI2"/>
    <dbReference type="STRING" id="91928.A0A0D1YPI2"/>
    <dbReference type="GeneID" id="27331365"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04282"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="90"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="571" mass="61917" checksum="C0AF2F9088C17D59" modified="2015-04-29" version="1">MSAIDHSVDASGISRHVPPWKQTALRAKEALSNSIPAKWKLPTTFETPDADFQRAALDCGILTSRQVALTQLTASELLSMLHIGALSAAELTEAFCARAAIAQQLVNCLTDFFPDEAIESAKALDAEHSETQKLRGPLHGLPVAVKDTYAVKGKRTTNGCAAWYDSEPAEEDAALVQVIKDAGAIIFARTTMPQTGMALETVSPLWGRTLNPYNSKFGSGGSSGGDGALVAMHGAPCAPVASDIGGSIRAPAAFNGLYGMRPTSYRVPRTGLVSQRLGQISINASCGPICHSLSDLKLLVKLIVTHPTLPYEPTCIAGFWKETSPKTKLTVGILATDGIVEPHPPVTRALRDVAASLQAAGHQIIEFKAPIDLWKAALTTWTLYFQNGANETKAALAASGEPLIAQFRHYLDVFNVREHTVSEISECHRQQAAYKKAFVDAWNATAKGTETGLPMDCIITPSAPLAGSPHDFPLWWGYTTIWNLIDYPSIIMPLKSFRLDPIKDAKDTGYHPRDNPFDKPNWEIYDPELWKTQPMTFQIVGRNGRDEELINSAEVIDNVVNTGHSSCDHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSM2</accession>
    <name>A0A0D1YSM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_02554</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238482.1">
        <property type="nucleotide sequence ID" value="XM_016376912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YSM2"/>
    <dbReference type="STRING" id="91928.A0A0D1YSM2"/>
    <dbReference type="GeneID" id="27329637"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02554"/>
    <dbReference type="HOGENOM" id="CLU_060983_1_0_1"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF60">
        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="15"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW18266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="321" mass="35719" checksum="38FAE7EC05EF02F8" modified="2015-04-29" version="1">MPPIPPAAVTTAWNHRIVCYFQTYHHNNEYVSLLPLVTNPSGVTHVILAAIHVNWDPGHLTLNDDPPDHEKYTQLWDEVVVLQDSGIKVLGMLGGAARGSFARLDYSEGRTDVPLARFEAYYAPLREAIRRYGLDGLDLDIEEPMSLPGVIHLIDRLKGDFGPDFIVTLAPVATALMAGRPHLSGFDHRLLEAARGPSISWYNAQFYNGWGGMNTTDAYDEIIRNGWPAEKVVAGMLTNPKHGGSGYVPLELSAAVLSLLVERYPTFGGVMGWEYWDALPQEENCWMWAYAMGLCMGMKRLRDAAIIVRMGRNLASININR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVK6</accession>
    <name>A0A0D1YVK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239542.1">
        <property type="nucleotide sequence ID" value="XM_016377972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVK6"/>
    <dbReference type="STRING" id="91928.A0A0D1YVK6"/>
    <dbReference type="GeneID" id="27330703"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03620"/>
    <dbReference type="HOGENOM" id="CLU_021170_0_0_1"/>
    <dbReference type="OrthoDB" id="3538597at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="1">
        <location>
            <begin position="59"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="773" mass="88151" checksum="7AAC3CF1A224DEBF" modified="2015-04-29" version="1">MKDRDVEEDTKLTPEEYLQLMDSVGYNIEGRTQPGLWGAYSSLFQDIRQIGRSNQEYFVKQFEQDDPYIVAKRIQANRLIEEAWSCFTKRDSEAGWRKEVEYRAFESFDSESVCRRCFKRLSKAKFEARPVDPDAAEELRRRRLRRRLCTCTALQRAGIDNSDRKENVRIFTREIDKNVFHEDITPQMRKRLGRQRPDRVIGLYPTRTFKRLLPSLKKNYSPYKKKDVVYPFIVVEAKAAENNGNASFGSMLRQTAFVVRTCMRLQQNMQAETGREHQCLVWDFLILGEEWRLYAAVPEGDGVRLFDLWHGSMLHEDGAFQLLLIIDYLCDWACDVYRQNILACLAGGRARLKGMRLSPSGTEVSSSQRSDRDMSNLRGISLPLRSSTAPDFGPTATVGDLFAAEVGNSPTHALPDCAVSLMSTTNTVDAHQWRNWEEADPHQYPWATLATIRHSNVVKYSNLQLTLPAGKKELEMCLDAIFPEMRAEEAAGRLLRTMCDDTMTIKTCWNSGTRRMGEETEPDIPVRAFVYAQCALNPESWHVTRRLLLILCCERALQHLAAIAHVALPARVVDDSVDSNVSCHQVLQAVDNLKLCTGGPSAGLAIFRRQLFLRATVNTCGHEELEWVHLSHPPTNGPTTWELGSILPNFSKKQEVMAPILTPYIQAESALQIIPTFHKMTNLAKKEVDIFRFKSPGILIKKPTTWPGKTPEFCLLVTEQNIHFDDKVRLGDMIEEAKRVDEVFGVVKQSAKYGSRDMAFFSQWAKSMKEGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWJ6</accession>
    <name>A0A0D1YWJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_00250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239892.1">
        <property type="nucleotide sequence ID" value="XM_016374616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWJ6"/>
    <dbReference type="STRING" id="91928.A0A0D1YWJ6"/>
    <dbReference type="GeneID" id="27327333"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00250"/>
    <dbReference type="HOGENOM" id="CLU_011171_4_0_1"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF41">
        <property type="entry name" value="MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="218"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="601"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="730"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="940" mass="103306" checksum="2A48EE32D4E13853" modified="2015-04-29" version="1">MPIEALPETTTRALGSTLVLSDAKSVVKELVDNALDARATAIGIEISTNTIDAIQVKDNGIGVDVQDRQLLCKRGCTSKIRSLDDLNRLGGTFLGFRGEALASIAELSSAVSVTTRVEGEIVGTTLKYTASGMQSSSSASHPVGTTFRVQDFLTKIPVRKQAALKSAAKTLQSVKSLLFAYAFARRDVRFSLKVLKSKNEKSDWVYAASRNASLSEVATKIVGKEIVSESVPYRWPPTEGEQGVEDGWSLDALLVSSDADVEKIRGGPQFLSVDGRPVNTERGIMKEIVKSYKRYLNRVLPKSTSISRPFICMQIRCPPESYDVNVEPAKDEVLFFRPDQLLSLVEQLFEKAYGGVDAPPKEHPEMGHPSVTIVSAPAINTADLQDVQEPSATDRNVRSQPSSEAEESFGAIRNPFTIAAMNKIVLPRKMGTFTRARASSSSGSSFVTLEPEEPIPGLLRSDYRQEFGQQDQLPSPTSSDGSDLLPYQNPGPPKRPWPQKDKQSLHTISDPRTSHGIDNTSTSQQMGLETWLTPQSQLRPQISRAAHRLAQGRASPNQDENVPAPNQSEDSTGAFPRVPVIAAGLRTGSGQRPFKAPLKRTMEASSQSSLASLTTSSGYRSSLTGSERHVERGVFVSPQRFGHRRDFDSEQRGRSLSSDEDRMEIPESSHSSVPGSELSEIMDFEHRKKTAIAHQKRLAATAGAAWHHPMASVRGILSQNKNVQIVHDAGSEPDEAGASPSDFEGGRPYNDASQTSMAKPNNPHRNRYLAAKRGLSHSHPERDEGIGPVRDEREGGFVETTSQMPAPEQLQIPDGDPRAYMIRHKQRQQGTSKLYRARSSRLPFETIPPHSMTLNLSVATRAFDDIGGFKRLVHCVATVDRYADSGTMTTRMQSVDIHDAMNDDYLETLREIVKEKYRFMSPEGRELVPHLKITMPGKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z079</accession>
    <name>A0A0D1Z079_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_01540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241177.1">
        <property type="nucleotide sequence ID" value="XM_016375901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z079"/>
    <dbReference type="GeneID" id="27328623"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01540"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="59"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW20961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="568" mass="61507" checksum="95AE1E6CFBD7F399" modified="2015-04-29" version="1">MADTAEQQTLQGLENDRDTMAPTIQPSKEQESEKAKSIDKVLETSTTQADLRSLRFWAILIALGFTSLLTALDATITSTALPSIVADLGGGDMYIWAIDGYLLALTSLQPLYGQLANLFGRRWPLISSVAAFVLGSGICGGASTMAMLIAGRIIQGIGGAGIGLLVEIVIADLVPLRQRGLYFAALFGLVSLGTALGPLFGGLIVSNTTWRWVFWINLPIGGFAFALLMSFLRVKWDKENSLATRLSRIDWTGNFVFIAAVTSILIALSWAGAVYPWSSYRILVPLITGFFGLIAFLLLQHSQRLCPNPTIPLHLLFNRTSATAYVLTFLHSVVMSWILYFLPVYFQGVRGATAARSGVQILPTILTILPFGALGGGLLTKFGRYKPIHFVAFAVMLAGMGSLTLIDEDSSTGAWVGYQIIGSAGMGLIISSLLPAVLAPLSEADVAQATAAWSFMRAFGMTWGSAIAGTIFNNRFNALAQTHITSNELRNQVAHGHAYEDATKAFVDTLSQSDRQQFAWTLNESLRRGWEVGTAFAALGFLIIAFEKQIPLRNNLETKYGMDKPKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0D9</accession>
    <name>A0A0D1Z0D9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PV08_01600</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241237.1">
        <property type="nucleotide sequence ID" value="XM_016375961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0D9"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0D9"/>
    <dbReference type="GeneID" id="27328683"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01600"/>
    <dbReference type="HOGENOM" id="CLU_000203_2_0_1"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000009">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="244"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="539"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="1008"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KIW21021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1107" mass="125843" checksum="FC4829A1466096C7" modified="2015-04-29" version="1">MPGRVVDTPKRRVLTDATNTHNTLKSPPSAKKRKLNGNGPSVSFHSSQHGPNGIRSKFGSSQPKSHFETEVLEKMTQDITGLKENNAEKDQQWDRPSLDDFDPHRDSLRFQQIEVEEGTLHGGRVTLKLFGVSETGHSILLHVTDFLHYIYVAAPVNFQRQDVEGYKVYLETQLAQHQPVIHSVQMVLRENLYGFQGNQKSPYLKITVTDPRFINRLRSAIEDGHANYKGMWKGVDSKILTFDNIQYVLRFMIDTGITGMSWVEVPTQKYHVMPQHERQSNCQIEAYCHYRDMVSLGNDGEWAKMAPLRILSFDIECAGRKGVFPEPNQDPVIQIANVVTRYGESKPFVRNVFVLDTCSLIVNTQIYEHDSESKMLMAWRDFLEKVDPDVIIGYNIANFDFPYLLDRAKHLKLPKFPYWSRLKSVISQAKDTNFSSKQMGNRDTKATNTNGRIQLDLLQLVQRDHQLRSYTLNSVCAHFLGEQKEDVHHTMITELYNGTPDSRRRLAVYCLKDAYLPQRLMDKLMCLVNYTEMARVTGVPFNFLLSRGQQVKFISQLFRKALEQQLVIPNLRNEASDEQYEGATVIEPIRGYYDVPVATLDFASLYPSIIQAHNLCYTTLLNKNTIEKLNLQKDEDYIQTPNGDMFCTAKVRKGLLTQILEELLGARKRAKKELAVETDPFKKAVLNGRQLALKISANSVYGLTGATVGKLPCLAIASSTTSYGRQMIEKTKKEVESKYTIANGYSHDAQVIYGDTDSVMVKFGEKDLARTMELGQEAADYVSGKFIKPIKLEFEKVYFPYLLINKKRYAGLYWTKPEKFDKMDTKGIETVRRDNCRLVQIVIETVLKKILMDRDVEGAQDYVKETIANLLQNKVDLSMLVITKALSKSDYTAKQAHVELAERMKKRDAGSAPALGDRVAYVIIKGAAGSKNYEKAEDPIFVLENNVPIDTKYYLDNQLANPLTRIFEPILGERRANSLLAGDHTRSISVAAPTVGGLMKFTKKTQTCMGCKKPLVGKEESKGAVCSNCQPRIGELYAKHVKKVGEMEVRFSRLWTQCQRCQGSMHSEVLCSSRDCPIFYMRMKARKEVEESGKELARFDEDAGAIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0F4</accession>
    <name>A0A0D1Z0F4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_01635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241272.1">
        <property type="nucleotide sequence ID" value="XM_016375996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0F4"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0F4"/>
    <dbReference type="GeneID" id="27328718"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01635"/>
    <dbReference type="HOGENOM" id="CLU_011074_1_0_1"/>
    <dbReference type="OrthoDB" id="4150467at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="562"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="620" mass="67163" checksum="E84936D339EE3C0F" modified="2015-04-29" version="1">MQVSNLLSNGEHNTLKKMAPAKSVSFELLLDEGSKTRARIPLRVVLNNHDSTESIITTVKNFYGIYDGRGVSFEDAVGITLIPSYENLSPESTVYVRIVPAPQQPLGAYPLPNYGNENGYEPKRRPSLGEPFQMLPPHMREQSHSPSRPASRLARKRSVSPTQYRGRRSASQQKGGPIPTASRGSSANGSLHEEDGYSDSEAGRSSVSGSKKARSEQYVSSEISTANVLQDGRRGQPIFDSSTLPLFVPPQVPVAASQSSISPQRRSLPQEGPSPFHPPAQKLYGLQQVPVLSPQSYGTGQGTYGFRAGAEVGTPVPQHGHRLRDRTNLYQGHNGRPSNGVLPTPDPTVASCISDEDVARTLIALGDVSNYSHGRTSNSTIDETLSGAADAASSTGATSDSDEYSDTEGGLPKYRKYLDDEDEDYDQSSPAREQDEFEGQPKTKKIKTKMHDGPSNGYRTKQSSSLKNGKSIKIRSNTLPKMTKHSSQPSISKMPSAPAANQARKLSTSSVSFQHPLAADEEDLSSKPRCQRCRKSKKGCDRQRPCGRCKDAGIGIEGCISEDEGNGRKGRYGRHMGVPVKKTSVDNATLDDPSMVHLGGHHNDNAVVGSSPDKSKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0S5</accession>
    <name>A0A0D1Z0S5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241447.1">
        <property type="nucleotide sequence ID" value="XM_016376171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0S5"/>
    <dbReference type="GeneID" id="27328894"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01811"/>
    <dbReference type="HOGENOM" id="CLU_1517685_0_0_1"/>
    <dbReference type="OrthoDB" id="3559694at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024316">
        <property type="entry name" value="APQ12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12716">
        <property type="entry name" value="Apq12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="162" mass="17264" checksum="20872E0E658F3378" modified="2015-04-29" version="1">MAPPQQYPLPPIVSNLADVYTSYVYPLLPGPLQSVSAGVASVLSSGIAAATSGDLVSLAAFVVVLYLTLKIADYVRRSVVAWVVFVVKIAVVLALVNAAFYVNSVGVQKALGDAEWLVNWLWSFVEDKVLNGAGTDNKTGPFAYYGGGRQQVPISRGKSKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z1G8</accession>
    <name>A0A0D1Z1G8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241697.1">
        <property type="nucleotide sequence ID" value="XM_016376421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z1G8"/>
    <dbReference type="STRING" id="91928.A0A0D1Z1G8"/>
    <dbReference type="GeneID" id="27329144"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02061"/>
    <dbReference type="HOGENOM" id="CLU_004184_7_0_1"/>
    <dbReference type="OrthoDB" id="4161734at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="532" mass="60116" checksum="06AC69769E5E4BA4" modified="2015-04-29" version="1">MQSIYHQADCVLVWLGLEDVSNSKIMHLLKRIDKSHHPARVRDGREWLPDGKCLDRYRSDLVAFLRNAYFRRVWVIQEIALGSEVFVVCGSQGVRWSALDALVGCIWKETPIRGRAIDHLAQLCQSRSRRLEAQPVSLLQVLSESREAEATEPRDKLYGILSLAFDSSLYVIQLDYSRTDSCVCLEVTRAVIWAKRSLDIIFVSSRREKSSLRLPSWCPDYLHWPGDPACNQLVPYVSGLDSRASGAPGPAKWRASGGSLVNRDVVRIQHRLLLTRGIKIGTINGLGCLPRERCKPCHTGDSFRPCSRSDRALFSAITRTLGLHGWSSPQANANTDNGDGISRLFYYLYTFDTSRKAGSKNSRYFKERYSTIIDWREANRNFRVFGKTLGERSNNMDASLYTGAFRDSVHALIRAAMRSGDNAWINPWNYGHTGHRLPAELGVALDGLQSLIRAELRLMTTSKDDVGWAHPDARLDDGIWLLHGCSLPAVLRPSGSHEDEHILVGYAYVEGVMNGEEWMRRETRDLRQVVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZD45</accession>
    <name>A0A0D1ZD45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231128.1">
        <property type="nucleotide sequence ID" value="XM_016384526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZD45"/>
    <dbReference type="STRING" id="91928.A0A0D1ZD45"/>
    <dbReference type="GeneID" id="27337294"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10211"/>
    <dbReference type="HOGENOM" id="CLU_034860_3_1_1"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237596" evidence="2">
        <location>
            <begin position="26"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="527" mass="57474" checksum="E71D774F268BBFBC" modified="2015-04-29" version="1">MRHTSRTNIVVCVVLWLLLVHIIRSSVLCRPLGLSWDRDVDDDNKNDHRKSSSSSPPSYEYQHVQDHGRDHGRGNSKGNAYVFYATSNLYACSAMVNVDRLTRVFRTPHPIYILVSRGVSEKYTRTFRDVYNVTVLVHEPPRLHDGAAPYYQDVMLKLLAFGLNNLTSTTPSTTSRVDPGPGPAGGRVERAIVMDADVLVLRSLDNLFGLVGGDFDADAGVVDVAAPHAYWLEQGQHRQQQHRQQEQQQQQQQQQHKQQHQQTNAMDGGRGTKRKGVTSAVMVLRLSDVLWERTENALDRVRRGDRVEVYDMDLINEEFFGAGLGGAGDDGGGGGGGGTVLPGAYCTLNSHWEVQEVPAWSRFSDEGYSRPPLKKTENSSSGGGGGGGVGNADRTHRSNSTTITAASDGAAAGTADGRGLVEDPLTSLFYGEAHILHFTALGKPWSVTVQSVHQARPEAHPLFAEQFLLWRRAAKYVCPALGVGETGWNEIVGKRYTHPGEAVAEGDGSAGPDVAASPVTDRFLDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZE71</accession>
    <name>A0A0D1ZE71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">PV08_10607</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231523.1">
        <property type="nucleotide sequence ID" value="XM_016384921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZE71"/>
    <dbReference type="STRING" id="91928.A0A0D1ZE71"/>
    <dbReference type="GeneID" id="27337690"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10607"/>
    <dbReference type="HOGENOM" id="CLU_035060_0_2_1"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="79"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="392" mass="43657" checksum="30DF9D656B114A51" modified="2015-04-29" version="1">MVRHKKDNSSKAKKYSTKPRPPPRASGRGADEGGGGERPPFKAACWDFGHCDAKRCSGKRLMHFGMMRELPIGQKYPGVVISPNAKRVLSPADKELLEQYGAAVVECSWVRVEEIPWSRIGGKCERLLPYLVAANPVNYGRPWRLNCVEALAACFCICGHQDWAEIALQHFPYGKPFLEINSQLFKRYAACQSEDEIKKAEETWLAKLEKEYTNSRLKGPSDEGDDWAGGNLNRREVFDSDEEGDDDNNEESEESENDNITHQQGVSLMPPDTDDEDEEAEMAEIRRKILASKPFSDSISTEARMGDPQQPHLEKQSTDSGLGSAIPESAAILVDSDAESGSGEEDYDDFDQIANATPVTDRIGIVARERQKKLEQASASFSRTIISAPKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZEA1</accession>
    <name>A0A0D1ZEA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231553.1">
        <property type="nucleotide sequence ID" value="XM_016384951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZEA1"/>
    <dbReference type="GeneID" id="27337720"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10637"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="68610" checksum="64875CF24D1B90E9" modified="2015-04-29" version="1">MSNSISDIIQDSPLGQALRFVTKGKLFAFPEDDPNFKIPWEIASVSEKEEEIEAGSVLPASRVASHQTSPPLSHRPSNVDEKDDDIESRVPGLTTIPTTHSSAAHSAIGPITTRTLTRERTIPYSRERFEVEEQEAIERRESSIIVPQRTSDGVILVDWYTTDDPANPQNWNSWKKAWAGLIIFLYTFAVYMASAIYTSAEGMVMEKFGVGQSKASLGLSMYVIGYGIGPMLFSPLSEIPIIGRNIPYIISFGLFVILCIPTALANSYATLLVMRFLTGFMGSPCLATGGATMGDMYGLLKLPYALTAWVAAAFSAPALGPLLSGFSVVAESWRWALWEVSWCAAPIFVMMFVSMPETSASNILLRRAQRLRKLTGNPNLKSQGEIDQGNISFNEVAINQLWKPIEICIKDPAVLFTNVYTSLIYGIYYSFFEAFPLVYLYIYDFNIGEMGVVFTCIVVGCIFGIIIYVSYVYWYLEPDIKKNGLRAQEHRLVPALFAVTLMPAGLFWFGWTSKESIHWIVSVIGITFYAVGAFILFQCIFMYLPLTYPQYAASLFAANDLSRSMLAAGAIIFAHPLYENLGIGRGISILGGLLGGGVLGIWALWYFGASLRARSKFAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZH69</accession>
    <name>A0A0D1ZH69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232498.1">
        <property type="nucleotide sequence ID" value="XM_016383875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZH69"/>
    <dbReference type="STRING" id="91928.A0A0D1ZH69"/>
    <dbReference type="GeneID" id="27336642"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09559"/>
    <dbReference type="HOGENOM" id="CLU_507165_0_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF252">
        <property type="entry name" value="CYTOCHROME P450 26B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="63982" checksum="310F5A9DE2D63FF4" modified="2015-04-29" version="1">MVSRLTQSFSFHSSPESFISARLGESTRSDGDALPLASRIVRAQILNREVHIVTSYHVCKAILCHQPGAIESVEEASLGRFDASKYDSEYAHVYAQGRTSISRGGVSPQRSRKCTVHAKNRGRSDDKANFFAARTAYRQFMGDFFPGSNLLLEDGLAHKIHKAKWRTRLDHLPQSSVSLIRQITESRFLDQLVRGRNPQEVDLYASLKSLVWDILFGVFLSISRDGNGRKFKQLEELQEALLRGQFSTFPVSISTPLWSSTRSRGLQAVEELEKSLATIARDVLASNGTSRSFNACPFSEQFRGTSLSSDDYLDTEDIVSHLRLFTSSIANKALASLLTAFILNLFVWRPSSSMTNTDEQGSDTSVSLAELIRSYSDPQKRDVMLNAVLAETERLSPPVVGVMRRVQQDVLISSADRDQPDEYEIPEGQDAWLYLSGANRDPDVYDRAGDFVWDRFLPFYSSSSNDATRANADCLGTDFRPPLPFTFGDGVKSCLGAEFSRQVCLTVAKTLVDESIMMTGRIEEGGVISWLGWERRTSRKDEVQLMARDLKQLPTQRPRRAIKVQIGRLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHW4</accession>
    <name>A0A0D1ZHW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_09759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232698.1">
        <property type="nucleotide sequence ID" value="XM_016384075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHW4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZHW4"/>
    <dbReference type="GeneID" id="27336842"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09759"/>
    <dbReference type="HOGENOM" id="CLU_138052_2_0_1"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="9">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW12482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="117" mass="13036" checksum="A72965DE524D6FB3" modified="2015-04-29" version="1">MANRGTRNRACMVCSIVQTGSEFFRNGCPNCEELLNLRNSQDAIQECTSQVFEGLITMTDPKTSWVAKWQRLTNYVPGVYATKVVGQLPQEIVDGMEDQGIKYIPRDGTSVEDEIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJR5</accession>
    <name>A0A0D1ZJR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233253.1">
        <property type="nucleotide sequence ID" value="XM_016382550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZJR5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZJR5"/>
    <dbReference type="GeneID" id="27335307"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08224"/>
    <dbReference type="HOGENOM" id="CLU_035146_0_0_1"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="56711" checksum="B9154E475CA4CC05" modified="2015-04-29" version="1">MVDRGWQRSKKNVRDDRTVLGHGSQKAGNHDITITIAGPRSSGKPPSTTAKRTTEANRAQERKVSVQFMQYEPPVSAAGQASERCRRTARRAKSVVQRRRGQAPSAAHPIVSPSPLSVRSSTLRQSIPGSASPLYTFIDPEVSSFQEFIAYYPTRLASALLPISKHAPVSSNAIKEIWLPAAINDEVFLHVILLSSAMHYVSTMNCEDVGDSNLLLKVIFDRLNRRLLTGKYSDTTIGAVSCLALNENGQGSHTQWAIHTAGMSEMIRDRGGMASIPPEKRLKLYRGEIIGAVDTLSMPRLPQPPRTTKSLYDTMKMSFPPHVTLLSAILESNVTRNMSDLLIDLSLFSQTLNYAAKSGVVIDSMAYEEDITRMQYDLLVIDTLGGTALDGACRLAALAFGQSIMQETPFRRSASVEISRQLQGILTVDDSAGFDSDLMFWILVMGALVSSQTAEKEWFRTKLRDRVSQRGHCFSWPAAKALLGAMFWVDCLLDVHGERLWHEVSGPTCVRQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZKS9</accession>
    <name>A0A0D1ZKS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233648.1">
        <property type="nucleotide sequence ID" value="XM_016382945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZKS9"/>
    <dbReference type="GeneID" id="27335703"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08620"/>
    <dbReference type="HOGENOM" id="CLU_033078_0_0_1"/>
    <dbReference type="OrthoDB" id="4148461at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-fist" evidence="2">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="587" mass="63906" checksum="EA4A5730E3B45768" modified="2015-04-29" version="1">MQESSGEKVSSPPKTGRVEDGKIRKIRTAHRSETTPIQHFNGKTYACESCKRGHRVNKCDHGRTRPISETNQPGRPSAGQRRGCHCPRNCACTTKTCKCQRDCACTQEMYLVVRVDAPQLISREATSSPKPVWEDANGNKMTLKKVWADANGKELNDEEYQERKRRMREREGGASKTAEASKSSCCGSKKPKEEPQSPEPLSTGGCRHRQNIENQPDSASLAATPAVPSVSVKQSWKAACSCGSACSCLYCPDHPNNATSINHTQQQVKNLAEQAYSEFDGLMPVSFMQGNDSTSCMGGRPTFFLSRTPNVSQQQLEQYFPQSSDPNAIYLRYPISQHSWTNQPASSHCSHVPSPTTVMAMTPDPSESYIEPLPDLSQPSLDYDFLPNNTNGTWDFSGGQFGGSSFSWMDFDASRGTDYNIGQATVASAMDGGIFSVSQALPGQQLPEVSVNMDAMLSPTHLNGLPALTSEQYPSPSTPFDAQNTYIDFTSPLADGRTHQASFARSPSAVPQVQSGPCLFSTQSMNPTPQTTQSLRAPQPQPSAGLAGSHYSIPISWDHFDPVNEDQTSGNLTTAPIATSPQLLSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZP80</accession>
    <name>A0A0D1ZP80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234823.1">
        <property type="nucleotide sequence ID" value="XM_016381721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZP80"/>
    <dbReference type="STRING" id="91928.A0A0D1ZP80"/>
    <dbReference type="GeneID" id="27334474"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07391"/>
    <dbReference type="HOGENOM" id="CLU_026244_1_0_1"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF6">
        <property type="entry name" value="CLUSTER-BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="90"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="358" mass="40280" checksum="43F9C7D5C2A31C56" modified="2015-04-29" version="1">MDSTWLRQHEWLTGVLLATGLCAVVMLGSRQVGTINVNTASSRTPRKLLSELDEHTPGEVAKVPDLPEGYWTSRSHFNLEKRAIFVKVPVAVAHASEFDSPGQYRVIDHPAGLPLVLVLGKDRVLRCFHNVCRHRAYPVVSTRREGRTPLLSCGYHGWTYDLKGQLIKAPKFDDVEGFERDNIRLHQVYTWVDSEGIVLVDLSRNAAVDNDALVSEGRYRNQRVERWQVPGKFNWKMTEFEDAFSPLSLDAANASSIVERVLGKRLVRLFQTRQVDYSQPSMLSALFVERNGSTRLFISISPTEVDRCVVSCTLITPPFTPSTSSKPEDVIGAVKSEISTSVSYLEKTYRQIAASDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPT3</accession>
    <name>A0A0D1ZPT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichothecene 3-O-acetyltransferase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235043.1">
        <property type="nucleotide sequence ID" value="XM_016381941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPT3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZPT3"/>
    <dbReference type="GeneID" id="27334695"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07612"/>
    <dbReference type="HOGENOM" id="CLU_026450_5_0_1"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="3">
        <location>
            <begin position="26"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="454" mass="50096" checksum="5D529AAB18724913" modified="2015-04-29" version="1">MAPNGTLHDFTHLQDVMGNLPMLKRYIVLCLCFRLPETYSSNEIESTLAVGLLRLAKAFPFLAGQVIMEGRRQGCSGRPKIIPLDERISLNVNDIRESHPAFPSLSELSTTKYPFTSLDPAIILPPIASSWPEDPNDFSQIAPVLILQANLVHGGLLLTFSCNHMTADMTGMGMIISLFAKACRLECFTDEEIEQGNQPRGNIVPLLGDEYEPSNELEDVMVSPLRMEEKNNPANCSEAATKPKPASTAVWAYFTITSSNLARLKTAASHQTLVPYITTDDAVGALCWQAILRARANRLGSHATSTFARPISARRYLGLSSLYLGHMVDVVYGSNVDVYELPLGDVAARLRMLLQSDEKITRHVRAFATMLDRVDDKNQLVNVTQTSGAVRSRSGRCLECHVARRPRMGAAPSLLYLMPKDKDGGMAVAMCLNDDDLMALRKDEDFIKFADYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQB3</accession>
    <name>A0A0D1ZQB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Subtilisin-like serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235178.1">
        <property type="nucleotide sequence ID" value="XM_016382076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQB3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZQB3"/>
    <dbReference type="GeneID" id="27334832"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07749"/>
    <dbReference type="HOGENOM" id="CLU_043687_1_1_1"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37398" checksum="74409A8D1C5E4A29" modified="2015-04-29" version="1">MIKNSQIAPAPPFSKEHQLCSELADSSPVETTSRVPGHPSIVLPNTDSLSTFLCNELWAADLEAAAGRLWILTTPSGRSVHSLNKQKVLGREIVVTEDPRLHLLWINNRIFIKPLPSYLTSYSFWTTALAAQPLSPLAEKSSHIRRAAIGFLRTYRLLIQHESDLVIAQRDDLRLVQSHLRWSEVSIFLADLEHIEDEHVSARYHYGEIRLSRLNLYAPLLFRRYIYEYIPMQYGEYFTRLYGPILFVFAAISTCLNTMQVALAADSGQEFLSEHVWRIFYWFSIVTLLITVVVGSFLVLLWTGTVANEWKFTLKHRQKVKGHKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZS20</accession>
    <name>A0A0D1ZS20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nab2-like CCCH zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235793.1">
        <property type="nucleotide sequence ID" value="XM_016379966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZS20"/>
    <dbReference type="STRING" id="91928.A0A0D1ZS20"/>
    <dbReference type="GeneID" id="27332708"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05625"/>
    <dbReference type="HOGENOM" id="CLU_027088_1_0_1"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055046">
        <property type="entry name" value="Nab2-like_Znf-CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22683">
        <property type="entry name" value="Nab2-like_zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nab2-like CCCH zinc finger" evidence="9">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="468"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW15577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="529" mass="56515" checksum="74A223760D3DFE9D" modified="2015-04-29" version="1">MSSIALETPLAEALSSAVHSKIVDEGWTQEDDTSLAEYIVLMLANGKTQDQIASELAGELLQDAKGTTEFAQWLFDQVNALSNGASGPVPPETSQSSEQVAEAAATASSAGNGVSAIPAAYDQDMADNAPENAPRGPKGLHGGRPAGRGGRGGPGNKGGDSVLHRTRGNDRINTHSMRGAPKGPRNIQNRDLRPGMQKALNGMNMSGQGMQNPMMMNNGQPGQPMMHMTPQQQMEFMAMMEQQTRMLAQFTGMMPGAGFGQGINQQNGQGRSLFDRVEPGRGRGGTRGRGRGGHQNGHGKGTKPDGDVSMEGDGQATAPDGSATEVEQQADGERKPQDPSNTMCHFNLRCTNKDCAYAHQSPAAPESTVVDMSDTCSFGAACKNSKCVAKHPSPAQRGAFQAQETCKFFPNCTKPNCPFKHPTMPLCRFGSNCKTPNCQFTHLQVPCRFHPCTNLRCPYKHEPGQQKATSLADYSWTPDKPNQSDGSKEHLSDRKFVDDQAGEEELVRPDGGVAAEANGNVGMREEVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZS93</accession>
    <name>A0A0D1ZS93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LEM-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05737</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235903.1">
        <property type="nucleotide sequence ID" value="XM_016380076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZS93"/>
    <dbReference type="STRING" id="91928.A0A0D1ZS93"/>
    <dbReference type="GeneID" id="27332820"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05737"/>
    <dbReference type="HOGENOM" id="CLU_010838_2_0_1"/>
    <dbReference type="OrthoDB" id="2503928at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HeH/LEM" evidence="9">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="8">
        <location>
            <begin position="317"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="666"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW15687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="79293" checksum="3FAF7727F0DD0AC8" modified="2015-04-29" version="1">MAEDNELYYLQPGFDLSTLTIPKLRSILVNHDIPYSSAAKKGQLLETIEQELLPKASKLLKAQARVRRTSKGITDVPSGQESTIDDDNEGDKQLMPPPKTPRSRKSRSDLATEHTDSAPSTSRRRTKTPSRRSTTRTPRASDTEPEVERTARKSRKSIPQPILPPAVKIEEPDARLKRESLEAGTSPFSDENPFQSGSSPPSGADRRKSASRSRKSLTATSTKKSPTKRRETRSPPIKSEDAEPSRASYSFPVSRITSDEQEDGVQITEEFTADAARELAEEERNGQVVPSRPSALVRRKKQKPTSTVAKTAPWAVMTTVLAALAGWYRQEKINVGYCGVGEPHWSLAQNPHIPAWVHQNLEPTCEPCPQHAICYPDMEVQCETDFVLQPHPLSVNGLVPLPPTCEPDSEKQRRIKAVADRAVEDLRERRAAYECGDTVSKADEAASSATANAQAVAKSTAPKLEVTEEDLKKSVSKLRRKGMTEQEFEDLWRGALGDIMGRDEVEVKHDKSGRLVLSSTSLARLPFGCAVRRSLVRTISQNRIPLGVLTGIIVALFYGRNKIMAYQRATAQIPGLVGTTLDRLATQAALYHDQRTPEAFISVGQLRDDVLRHVFSASERERVWQNVRKIVESNSNVRAATREGGKTGEWSRVWEWIGPVDLAPGLEGRRSGGGGLIEASSSTRRAEGGVEEVSRTQTPDRSNVEVRRWDEGRPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTK8</accession>
    <name>A0A0D1ZTK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236328.1">
        <property type="nucleotide sequence ID" value="XM_016380501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZTK8"/>
    <dbReference type="GeneID" id="27333246"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06163"/>
    <dbReference type="HOGENOM" id="CLU_752337_0_0_1"/>
    <dbReference type="OrthoDB" id="10596024at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="368" mass="41592" checksum="73EC0A9BC9BA3F9E" modified="2015-04-29" version="1">MTRGSLVFGKHGIFTFVLKATAVFICGGSSLRLELKRRRRTRLHRTHIDLTIDSDEDPAARKVRVKHEIKNEEPPKVAMLTQQINPGTQHITEQEITGNTAVVTTDAPATTIIGPSTTSAAPLPFRPTTPTVRESYHFVNVTSSPQPRKIVFSTPVTSHSPDISHGNATSPETTGSLDSSRPARTHPSHKCTLETSSDATKYKHNSPQSTSTKATNPTSSPKATLKTRRTRRTKSPREMVHNYWLSLRYYFKNETGLTLPQGAAFEKLTRTYSLKYGRDSDAETPEELHKRFDYRVERDGGKYDELPPTLRQDLAWVSSFCHVWWPAYKSIPRQEELERLIEKVIHDIKKGSYNEEDYHEIASTGRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWW7</accession>
    <name>A0A0D1ZWW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237403.1">
        <property type="nucleotide sequence ID" value="XM_016378726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWW7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZWW7"/>
    <dbReference type="GeneID" id="27331461"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04378"/>
    <dbReference type="HOGENOM" id="CLU_006237_0_0_1"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="677"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1056" mass="116309" checksum="2C1E58D0E821E77C" modified="2015-04-29" version="1">MAAIAPSQSLPSDNSNAGYSKTTRRQYQSCDQCRKSRRACDAGSLRVVNFPFTDEDAIGLPRPSCEACSNCARTGKKCTFEWLRSLPRQGLPKGIKRKLDSNVVAPVPTASERETGREATREQSYSSSSLPVPDAFLPSGPIALEERHTSSHHHHSNGYASAPSTLLPHLPSSDFRQGSPESKHADALPEHHPTASRAVGSSSRRDFPCRQNTSSDFHPPALPGSDSSTSSASYEALSSRKGTALSHTSDSGTSASSDSGPGNGRAKSQKRDQHTGAAYGANRSDESSLGNSARRGSSTSTSLSGKKRQSSSPLMNRGQIRFADGALKAMIASGLLRIYHDSFENSLSCWVTEKNCPYETELAELIAQAGPSTTAEEAALRLGDNRIFSRVSRLDSAFTHLRGRQLSARDNKAATDALNSAIMAFASQWSHSSHNTFWRSKEGLSRMRAWQNNNNNAFLPPGTQPNESTESTDFERMIQKTLWHEARKAIQETTEIDSFKVILAYMLFALTQRPPDENQKPKPESTGDAASSDNGNTNTNPLESVCREYPGSGCPPISTGPAGAETEWDPFQTAELEGLASPPVYLETAVRNLFSWRRKVERYRRKSSACQHDGKPIPKLDLKDQQTFNILFWLGVMCDTTSSAITRRPLVIPDEDCAMIREKLDKLSLSGSQADEPSCTTTSFSSSSSPSCRYDDGTYDSSATAPLWDTYLLTFTPARTHTNPFSLPSPARWPCSFEQAAQILQEAIPVKVLMFRRVAHLQTLAARRASPSSLESTITAALDVYSHWNRTYLPFMADCVSSHNDLPPHVQSWYVILDGHWHYGCLLLADTISQVDAEQRTMQVQRDLRRKYGLLAELRRDNARAVARIAEASLSEHAPVFRNNPDFHFACNGSAILTEPWTDVLVRAMGSACRIFINWINVHQNHHNHHHNDHDPTHRWVRENTNLANLYIQAEYCIQGMALLGRKSDAANYTAGVFWKKLKEVYYSGSGGGGGGGDVDNANFNINTNATYTTNTSILTTTTTTTTTNAYTYTNMSSYSNPLGEFDNVSMKKEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYP1</accession>
    <name>A0A0D1ZYP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238003.1">
        <property type="nucleotide sequence ID" value="XM_016379326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYP1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZYP1"/>
    <dbReference type="GeneID" id="27332065"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04982"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36272" checksum="5793C71A0510EFFA" modified="2015-04-29" version="1">MPSFGDFVHTQFVLKIPKPSASFTSKTVIITGGNSGLGKEAAKHIVRLGASKVILACRSQSRGKNAKQEIEALLKCSPDIIEVWELDLESPSSIKSFVERANDLPRLDVLINNAGIQTIKFKVVYDTERCLAVNVIGTLLLALQMIPKLKESTRTHGTTPHLTFVGSALYDAAKWPENHSDDIFAWFKEKSHMDPMNQYNLSKLLLMFAVIKLSAAVDPVETSETNPIVINTLDPFFCKTGLASELTGVIKVLFKIFEAIAARSSEEGSRLVVQAASAGRQTHGLYMRAGAVQEYAPVVQDDKRVSYVWDLLCKKLEKLQPGILQNIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZ92</accession>
    <name>A0A0D1ZZ92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW17982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238198.1">
        <property type="nucleotide sequence ID" value="XM_016376628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZ92"/>
    <dbReference type="GeneID" id="27329351"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02268"/>
    <dbReference type="HOGENOM" id="CLU_1722395_0_0_1"/>
    <dbReference type="OrthoDB" id="10552340at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="152" mass="16798" checksum="578313FD316112F9" modified="2015-04-29" version="1">MGRCTPCQNSNSVCFVLDGCSKCSSCTKKGVKYCDGTFSDEEFDSLTAQRNRLVEAARQKGAELAQLIAAVNKAHSKRERLQREADLLLEKQKQMLVREAESLDALDHVDPPEKASATVFIGMDDKQLEEMFELSPGALLNFEGPISIDRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0J0</accession>
    <name>A0A0D2A0J0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238698.1">
        <property type="nucleotide sequence ID" value="XM_016377128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0J0"/>
    <dbReference type="STRING" id="91928.A0A0D2A0J0"/>
    <dbReference type="GeneID" id="27329853"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02770"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="287" mass="30838" checksum="1E9BF9ABEF1F6CCF" modified="2015-04-29" version="1">MATSKVWFITGCSSGFGKALALEILGRGDKVLASARNATKLEALKDAGATVFGLDVTSPLGELKGLVEWANNQHGRIDYLVNNAGYCQVGGLEELTPEETEAQFTTNVFGPLNVTRAVLPYMRARRSGVIANFSSIGAWRGTPAVGVYEASKWAVSGITETLRLELAEFNIRVCSIEPGYFRSDLLASGHKNLHQRVIADYDGTAVRRTEERVERTNQNQPGDPAKGAKVIVDVLTGVAGKGDDIPVRIALGADANRIIKGKCEETIALLDAWVAITSTTDFDEPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A151</accession>
    <name>A0A0D2A151_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PV08_02996</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238923.1">
        <property type="nucleotide sequence ID" value="XM_016377353.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2A151"/>
    <dbReference type="GeneID" id="27330079"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02996"/>
    <dbReference type="HOGENOM" id="CLU_001031_0_2_1"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000024">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="21">
        <location>
            <begin position="33"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="20">
        <location>
            <begin position="174"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="19">
        <location>
            <begin position="440"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="22">
        <location>
            <begin position="673"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="19">
        <location>
            <begin position="871"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KIW18707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1381" mass="149622" checksum="FDCE3800DF32FC96" modified="2015-04-29" version="1">MAEICVIPGGSAFSDFRREGLASQIGVKDVQGQYVHYVELISDLDSEHRALLEKLLTNVLQDNGLERHDGSSQTFYVLPRPGTISPWSTKATSIAHVCGLRHIVRRIERGIKLIITLEDDKSLDVSALNFLHDRMTETIYEGEPDLDVLFLHQEAGTLGTYDLYKDGKSPIEVLEQLNKDLGLALDPSEIQYLAEAYAKDGSVPRNPTDVELFMFAQVNSEHCRHKIFNATWVIDGQTKLNTLFGMIRNTHKVTSEGTISAYSDNAAVLQGSQGSQWAPDDVNGQWKAIKERVDFLAKVETHNHPTAVSPFPGAATGSGGEIRDEGATGRGSKPKAGLTGFSVSDLLIPGHRQPWELDYGKPHHIATSLDIMLEGPIGAAAFNNEFGRPATTGYFRTLLTEMKTGKDSSEIRGYHKPVMIAGGVGTVRPQLALKNPDLVKEGAKLIALGGPAMLVGLGGGAASSMGSGEGSADLDFASVQRGNPEMQRRAQEVINACAALGPERNPIQFIHDVGAGGLSNALPELAKDSGLGAQFELREVDCADNSMSPLQIWCCEAQERYVLAVNPDDMNKFRSIANRERSTISVVGHATNQQALKLTDRNNPSSHGHQDPIDLPMDVLFGKPPKMTRTVTSRKVDLPAFDTSLSMYVPQASTHGLLEEAIGRVLQMPAVGSKSFLITIGDRTVGGLTARDQMVGPWQVPVADVSVTATSLTPDIKTGEAMAMGERPTLALISPTASARMAVAESLMNLTAADLPDRLHQVKLSANWMSAASHPGEGAAIYEAVETLGMDLCPQLGIAIPVGKDSMSMKMKWQDKDTNESKEVTAPLTVVISAFAPVVDIKKTWTPQLKRYNEVGESTLFFVDLALAHRAMGGSILAQSFKQIGDESPDIRSVNLFKDFFDATQQLHEQDLVLAYHDRSDGGLFTTLAEMSFAGRCGIEIMINEICPTPNTPDVISCLFNEELGAVFQVRKADENRFKACFATCGPPPGLIHKIGRVSTKSSSQNMAIYHGGKLVYRGVRSELQQQWSNTSYWMQRLRDNPACADAEYANISKDSDPGLSYNLTYKPKENINSYKTSLLSIVRPTTRPRVAILRDQGTNGHAEMAFAFDAAGFTAVDVHMSDILDPKSHQTHLGLEHDLSGFTGLALAGGFSFGDCLGAGQGWAKSILFHRDARRKFQAFFERKDTFTLGVCNGCQVLSKLAELIPGAGQWPSFERNESEQYEARVCMVRITDPPADSGLAPSVFFHGMSGSSLPIAVAHGEGRACFTDAAAAAAANGKNIKALDAQLASDFASSHLAPLRYVDNKSLEPTTTYPANPNGSPSGIAGVRSQDGRVLALMPHPERTILQGVGSYIPDGKSAEWGEYGPWVRLFQSARRWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A2Y5</accession>
    <name>A0A0D2A2Y5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_03576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239498.1">
        <property type="nucleotide sequence ID" value="XM_016377928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A2Y5"/>
    <dbReference type="STRING" id="91928.A0A0D2A2Y5"/>
    <dbReference type="GeneID" id="27330659"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03576"/>
    <dbReference type="HOGENOM" id="CLU_009583_19_2_1"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000053">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="11">
        <location>
            <begin position="42"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="10">
        <location>
            <begin position="211"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW19282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="500" mass="56326" checksum="80EE641853823A8A" modified="2015-04-29" version="1">MPYNIAMVSDFFFPQPGGVESHIYQLSSKLIDRGHKVVIITHAYKGRTGVHYLTNGLKVYHVPFLIIYRETTMPTVFSFFPIFRDIVIREQIQIVHGHGSLSSLCHEAILHARTMGLRTVFTDHSLFGFADAASILTNKLLKFALSDVDHVICVSHTCKENTVLRASLDPLMVSVIPNAVVAENFQPRNYVPQSDELSYMRPRPVPQRLGPGDTIVIVVISRLFYNKGTDLLIAAIPRILAAHPNVRFIIAGSGPKAIDLEQMLERQMLQDKVELLGPVRHEEVRDVMVRGHIYLHPSLTEAFGTVIVEAASCGLYVVCTRVGGIPEVLPAHMTTFAKPEEDDLVMATGKAIAALRSGKVKTERFHDQVKMMYSWTDVALRTERVYDGITGAISEQEFYGQYASANWSATRGRSYALIDRLKRYYGCGIWAGKLFCLCVIIDYLIFLFLEIWAPRTSIDIARSWPRKPFINDKNKPVENGLLRRRGTDLMDRRNGSLMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8D1</accession>
    <name>A0A0D2A8D1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Septum-promoting GTP-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241223.1">
        <property type="nucleotide sequence ID" value="XM_016375947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8D1"/>
    <dbReference type="STRING" id="91928.A0A0D2A8D1"/>
    <dbReference type="GeneID" id="27328669"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01586"/>
    <dbReference type="HOGENOM" id="CLU_041217_0_0_1"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
        <property type="entry name" value="Small_GTPase_Tem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="279" mass="31541" checksum="78A96CEE02E1F4A1" modified="2015-04-29" version="1">MDFAPHNEYPADSAQVNDNYQHDESTAIPAMPSHQATATPPLDNDTNQRYHSPSLYPQPNSRPGSGMGGHQQTQYQENRQSQSSNKSSVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPFLIGTKYDHFVNFPREDQEEISNQARRFAKAMRASLIFSSTSHSINVQKIFKIVLSKAFDLKCTIPEIENVGEPLLLYQSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8F5</accession>
    <name>A0A0D2A8F5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241258.1">
        <property type="nucleotide sequence ID" value="XM_016375982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8F5"/>
    <dbReference type="STRING" id="91928.A0A0D2A8F5"/>
    <dbReference type="GeneID" id="27328704"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01621"/>
    <dbReference type="HOGENOM" id="CLU_022730_0_1_1"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="462" mass="51489" checksum="A1BF7D6A1480AFAC" modified="2015-04-29" version="1">MTRQHTFNSLPAHETFPNPTSTVPCWRTELHPLDNYRSTEELPSTSDIVIIGAGMTGISIAYHLLQETSPESAPSITILEARQVCSGATGRNGGHLKLASWIVKDKLEQWSVEASRELIRSHLAHIMALKNVIEKEEIDCDFLVTRSFDVFMDSGEARQSEGNLRMYKDMAMDELEHVDLLGPKYLEAVTGVANSKGAFSVPAAQLWPYKFVTGLLNTFIDRENVNLQTTTQVTSISDHQDPNGFFRIETSGRGTILARKVVYATNAYTAGILPMYHDTIVPVRGTGAHIVPLRTSKDPTLALQRRVNTYTYNIFHRRGQVDHLVHRPDGGVVIGGARVLFIDDPEQWSGVVDDGSLILQEQVTPYFERVMTEHYQDWRESGAKVDKLWTGIMGYTTDGAAHVGNVPGRKDQYVCAGFNGAGMVYIFLTARGIARMMLGTANFEDSGIPRVFKATRERLEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A9V3</accession>
    <name>A0A0D2A9V3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Indole-diterpene biosynthesis protein PaxU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241723.1">
        <property type="nucleotide sequence ID" value="XM_016376447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A9V3"/>
    <dbReference type="GeneID" id="27329170"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02087"/>
    <dbReference type="HOGENOM" id="CLU_036503_0_0_1"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34059" checksum="B7AB0C9F3847EF8A" modified="2015-04-29" version="1">MELSGPIPELQTGEQHPDPYLADFTRLGPQIFFYEPRGSIPSDADDVTTPDLIILCSWMGALPRYIAKYTKPYQSIFPRSPILLLKQDGADLFWKPRYFQGHAIQPALSVIRQVVQEKLPGKPRILLHIFSNGGSYSALFLADAYRNSSPNKDETLPISALILDSTPSLPSSKSGHAAISELLPKSEPMRTVSSAAIWAFIGIAQTYETLSRSENITIWLRRKLNEPGSAFTQDGLKRLYIYSQADALIPAGDVESHAKEAVDIIGEERVQLEDFETSRHVGHAMLNGQRYWKLVEDLWKEMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AA48</accession>
    <name>A0A0D2AA48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241843.1">
        <property type="nucleotide sequence ID" value="XM_016376567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AA48"/>
    <dbReference type="STRING" id="91928.A0A0D2AA48"/>
    <dbReference type="GeneID" id="27329290"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02207"/>
    <dbReference type="HOGENOM" id="CLU_494339_0_0_1"/>
    <dbReference type="OrthoDB" id="3469225at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="62888" checksum="CA22D26859C2810D" modified="2015-04-29" version="1">MPFRPPEKMLSSDDGVECGPSSERQVSPPSSATPEIKESPQMNLLWIPHANSATKDDAKPDHREINRRAQQNAFMKRRQARHGKEPPPRRVRTTPSLSSGGVAPMSAGATPEAMYSPQSWPQSTSLTTTISASQDYQAPSVRSYLDSLRIDPFQSGKVTMVPQMENIFMYYFTTIMPAVEPVQSEREEYNSWLVPLTATEPALMYALVGCMAYDIEQVSVVGFGPNSRRNLTQERVHYRIKAIQALNEALADPKKATSPSTLIAVHFLLWQEIFAGDECVHLDGVKRLLELRGGFDGIQRKAIEAIMVGSSWRAIRTRTKPLLPMVKDDMPLSDEDFLQVLAASEPSIARLGEGLLEPHMRQFFDDEFWQLLQDTRHAWVCFEQIGMQKFAPDVKRHISIKRVNIDHRLLSYPFDHYGTPRAIQEVCRQALITFSNAHYNVIQPSSKIARGLVQDLKTALEATDLPSCWGPAHEALLWVLFVGAHMSYGERERPWFVAALVRVTQTLQPRDWLRVRSWLVRFYYSDRVFQDSFRRIWEEVETLSTILPRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT01</accession>
    <name>A0A0D2AT01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230069.1">
        <property type="nucleotide sequence ID" value="XM_016386261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT01"/>
    <dbReference type="GeneID" id="27339037"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11954"/>
    <dbReference type="HOGENOM" id="CLU_114960_0_0_1"/>
    <dbReference type="OrthoDB" id="4538538at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="172" mass="19890" checksum="466EDB32220F7D7B" modified="2015-04-29" version="1">MPIYLSMQRVRFSSPDAYEKFKVLFADTRRHLMTLPGFLHLTWWEHPDDRSWYNECSFWTSRGALYDWHKNTYHKYCKTWAANGAIMEDIITNFELVGTRLLRVCPVCNLAVDKKYDLAQEQAVLHEQCPQCGFHFPVLEETPSSFAVFKDAVVGTDSKNAEGDKAGEQSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AW54</accession>
    <name>A0A0D2AW54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_10257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231174.1">
        <property type="nucleotide sequence ID" value="XM_016384572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AW54"/>
    <dbReference type="STRING" id="91928.A0A0D2AW54"/>
    <dbReference type="GeneID" id="27337340"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10257"/>
    <dbReference type="HOGENOM" id="CLU_008900_0_0_1"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16871">
        <property type="entry name" value="ARID_Swi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="287"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="389"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="892"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW10958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="981" mass="107337" checksum="282E3A22F04C7D2B" modified="2015-04-29" version="1">MNPWLPDSSSTPNNHVGFGGTMDGGMSFMQPPQTINPAQFQNPAFLNGAGRTASPATFHNPVYQTNPVIPSKRARDDSLGASPRQAPGGLPVSRAQTPGQGPYPGYNPQANGAHSITNTPTPFQHLQTSANATPSPTVQQLNQFNPPPGNQRVSTASPNPFSPQHGPPHASPGPSDHAGRVGTPHDNPQNFMPNGGFQQGFGQPQFGQNMNNVMPQMGMNPQPNMPQQHPGVSAAQRNYQMQLQAQARQMQAQTQARGMNAIPPNSGQPMPNPQLPQGPGQFQPPKPNNPEEFLRGLQTFMASRGRAVDINPVICGRPIQLLRLYAAVVKNGGSQRISKMNQWGGVAQQFGFPPPQLMQAAQELQGYWHNNLAPYEAAWQMNQQKQRMAAQAAIQNQNQSQSQSQTQMSPPREMNINQDARHQRSSSASMNGQAQHQAQQAVANGLMQPPHGQQDPSVTPQHQQNMSRQHDPQQMNAIQAQSHGPIPQKQPPAAIVKPAEPEVDYSKPLSNPIEDPFKPEALPMSRYHGPINVEEMVVIGQHIADMKPIVPAIREMGLIDIHAITMSIKSGMHAETRLALDILTNLSTEPALQLSLVDCDDLMDSLIDCAQEEVNFLSEHATEVSDDMFLPSYEELIRSVKTENESLPDIPTFGTVAYDLERAADRLICITTLIRNFSFYEANFGVLGQPEVLKLLSQVIRYLGTTEMFLRHHQNALDFMKDVVIFLSNLSTSLQLPGKEEAFCILHFLLAFAPTPGPITSSGKISFTMYTPSSHKYLPSAVDSLAKLLARDEPNRMYYKSIFAADAHSTQPHELLTRSFGLAISPVPANSNQTRTIIEARKPFLLQGMLAAEILANLVPGSEQQLARKWLESEDGFAGNLLRLVGLLSADRTTQTAPRQPQQNSRHPQETDVNGYGAISNRAMAVLKTLVQKARTVDTDGATVVPLGVMPKRESLLGAMIQKDIDPGILRQLCVYAALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWD7</accession>
    <name>A0A0D2AWD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10302</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231219.1">
        <property type="nucleotide sequence ID" value="XM_016384617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AWD7"/>
    <dbReference type="STRING" id="91928.A0A0D2AWD7"/>
    <dbReference type="GeneID" id="27337385"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10302"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="106"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="276"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="487" mass="53595" checksum="3290DED24F8FB9FD" modified="2015-04-29" version="1">MVEICCETVDASLYKVRELLPGFIAAVSKLVRQSNSFFFRQKKRFAPLAIMNTVAANKAEQAIGDRPTATTNQYKTRPNETMLALRWYGDRDVRVEEVPAPTITEPADAVVKVTGTTVCGSDLHLYHKEIMQLQKGEILGHEFMGIIDEVGPAVKGLKVGDRVVASFQIACGECEFCKEGLSSMCDRTNSSALQEKLYGKPFAGLFGYSFFAGGFPGGQAEYVRVPFATNNLLKIPDHVPNEKALYLSDIVPTSYHATVCAEVSKGKSVAVWGLGPVGMLACKWSKLEGARRVIAIDQVPERLALARDLGCDTIDFSKVKDVVAEIYKLEPQGVNCCIDAAAFRYTKTLLQSAERLVGLETDSSEIANETIRACRKFGTVSIVADYAAMTNQFLIGALMEKGITYRGCGQAPVQKYWHQLLKKIESGEFDPTIVLTHRFSIEEFSGLYEAFDKKKYGILKTYVQTRFSPPPTPGTPKLSSFASGDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYH0</accession>
    <name>A0A0D2AYH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_10740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231656.1">
        <property type="nucleotide sequence ID" value="XM_016385054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYH0"/>
    <dbReference type="STRING" id="91928.A0A0D2AYH0"/>
    <dbReference type="GeneID" id="27337823"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10740"/>
    <dbReference type="HOGENOM" id="CLU_007003_5_0_1"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF77">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="750" mass="84235" checksum="9773E75EB3F6F493" modified="2015-04-29" version="1">MTSQPAAQSEQNKGKGKHVSTACSGCRRRKIKCDGITPKCSNCVLYDQECVFQYGVDKRKIAPKERLQALTAYCHQLESLLRTHGIPLPRPPPLHVQKDGIGEFSPTQAGNTAVVTSSTWSSAEDQDQKTHNGHGISNVYLVPDLDDKDSYLDGGVDAAATEVDQPYPESDTLADQLSGRMGSLQIAEDGQLRFYGATSNLHILHNGPLSLSRSRFRSLSQEGSNLLHGAGVGHLVDQDLEDHLLRLYFCWEDPTIHVVEESIFWRERRRCLSGHHFSSYYSEVLSNAMCAVGATMTSRKCPHLPEPLPDFFATRSKTLLDLEMDAPTLSTVQSFAILSGIEAALTRDARGWLDSGMAVRLAVDLGLHLDPEPYVQAGIITREEQIIRKVVWGGVFVHDRMWSLYVGRPVALDDKHITVRWALPENLMGTKPKYWSSYTDDDEAPDSPVVLDPIDDLCYWNIKLCANMTAIRETLYPDGIGDVRSLRQLCDFATEMSQTLALWKDGLPESLSVNYDDTTTYYLPHVLQLHMQYHCVMIITNRPFFASTRKMIDLSPLEISNRRDACTDAADDIARLVHIYRRLYGLRRINIQAVHLLFTGTLIHVFTACGALDKTKSDNAWKNLETCCQALSEMSLSFKNAGRAFEVIMSIKSDLLKRSRSRLKRSNPWHDGQDFDADSQRKRRSTMPESELLPFEDFGASNFDPSFDSAAPLNFFDTSYDDFSLDSLFWTGFNSLELPHLPPQNPQNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYR9</accession>
    <name>A0A0D2AYR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232079.1">
        <property type="nucleotide sequence ID" value="XM_016383456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYR9"/>
    <dbReference type="GeneID" id="27336219"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09136"/>
    <dbReference type="HOGENOM" id="CLU_089363_1_0_1"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053146">
        <property type="entry name" value="QDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="72"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="225" mass="25753" checksum="6EF4906E5BB92322" modified="2015-04-29" version="1">MLSFLARTPPRTRVAHLNKIFFDDGRSAIEFKAPSDRYLVINRLPPAPIKHGDDDRKNPDVTPHAPNCALNPPMHWHFKQDEFFHVLEGKAAFFFDGRQRVATAGEVVKIPAGKFHTFRNASPKDDLVVEFVLDPSHRVRDEEFFRNAQSYRDDCRKAGVPRNIFQVCLFNNRANVVLALPGPRLIAKPLGLLFNFLGACIGRWIFGFEDSYLEYYDPRNSSVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B030</accession>
    <name>A0A0D2B030_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanine nucleotide exchange factor synembryn</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232544.1">
        <property type="nucleotide sequence ID" value="XM_016383921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B030"/>
    <dbReference type="GeneID" id="27336688"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09605"/>
    <dbReference type="HOGENOM" id="CLU_015532_0_0_1"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="50508" checksum="BC4F067D73A814B9" modified="2015-04-29" version="1">MPDSTRQTEAIKLLGQLRDDLEAKKSSNEQIRAALDRLKVLGRDAGNVSTLYNEAGVKVLGSYAFGEYPAGVRQEALRCIANALLLLPITRQHSISLGLDKKSTDALGDANLDEEFLLSRILFLLTYDPRIDLQTLLDDHKLADKITKLLNRHVDQSKTTQTANPDSPALQETLKLLFNVTSGGAGLNDRTSFISAIRPLFQLLDQLPSSSPPLKPPTGLVVNALANIDFDETPEQDPAFGSGVDKLLDLLSSVVTTYPPTELETSIVPLLTTLRNINVNASPELRAKLKNRLLPDDNERDQPLGKSSSLASHLLRLTTSTGSTNLSEAISGLMFELSDKDASQYVHNVGYGYAAGYLMTHKIPIPDNAKTVPQQGRSGSNPGDRNGGPSRTVPVNPITGQRIDAEPAVQVPEMSREEAEREAERLFVLFERLKATGVANVTNPVQLAMEQGRLQELSDSDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B205</accession>
    <name>A0A0D2B205_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="2 12">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_09913</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="2 12"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232851.1">
        <property type="nucleotide sequence ID" value="XM_016384228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B205"/>
    <dbReference type="STRING" id="91928.A0A0D2B205"/>
    <dbReference type="GeneID" id="27336996"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09913"/>
    <dbReference type="HOGENOM" id="CLU_044271_1_0_1"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="16">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="17">
        <location>
            <begin position="144"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="227"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW12635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="333" mass="38504" checksum="2E54E46B005082E5" modified="2015-04-29" version="1">MANSKYEYVRNFERDEHLLPNTWIVVRIDGRGFHKFSHHYGFKKPNDARALDVMNLAAQHVVKILPDVILAYGVSDEYSFVFHRSTALFERRNAKLVSTVVSTFTAAYVMMWSSFKLDDRGDGKLDIDMLPTFDARAVCYPSWENLRDYLSWRQVDCHINNLYNTTFWSLVQQGGMSQTEAEEFLKGTLASDKNEILWSRFGINYNDEPEMFRKGSVVYREYALENTPSTNTNTNINTRTRSGGGQGRTKGPEKKVEVEVETNDDHVEGDVDDDGDDLRDNSEKQVLSKTQAEKMRKARQRAKIVTAHVDIIKDEFWVRRPWLRSGRPGRPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3M4</accession>
    <name>A0A0D2B3M4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08462</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233491.1">
        <property type="nucleotide sequence ID" value="XM_016382788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3M4"/>
    <dbReference type="STRING" id="91928.A0A0D2B3M4"/>
    <dbReference type="GeneID" id="27335545"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08462"/>
    <dbReference type="HOGENOM" id="CLU_001715_0_3_1"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="207" mass="23198" checksum="364ED52C78158C7A" modified="2015-04-29" version="1">MAPAPSDARPIVFSGPSGTGKSTLIKRLFQKHPDLFGFSVSHTTRQPRNGEEDGVHYHFTTVENFEKMIAEDAFVEHARFGGNYYGSSKRAVQDVADGKGKSIDGSTAAGKRICIFDIEMEGVKQLKKSTLNPRICFIQPPSMEILEQRLRGRGDTAEEAIQRRLAQAKNEIEYCKQEGKNDKVIINDDLDRTFSELDEWVMQDISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4Y0</accession>
    <name>A0A0D2B4Y0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08951</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233976.1">
        <property type="nucleotide sequence ID" value="XM_016383273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4Y0"/>
    <dbReference type="STRING" id="91928.A0A0D2B4Y0"/>
    <dbReference type="GeneID" id="27336034"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08951"/>
    <dbReference type="HOGENOM" id="CLU_010194_14_0_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="311" mass="32611" checksum="4B7B5A75F688E921" modified="2015-04-29" version="1">MSVQGKAAIVTGAGLGLGRLYALALAARGAKVLVNDYGGDLQGQAGTITRAQAVVDEIRAAGGIAVAHNGDVSKDAKDIVQTAVNEFGSVHILINNAGITGKMSPHDDVDGPAFMRVLEISVLGTTMVTSAAYSVMAKQRYGRIVNVSSNAIYGFGAGGDCAYGASKGAVFAITRELGRWSERDGIKINCIMPSAASRMGDLSEGTKKITRTYFPPEGVVPFVMALCSEECPSSGEVFSASANRAARETLATFPGKISDTAEGFLADWDKVYGKDETPFLGDSTLDQVKYIIRIAHGKEMEDIPEFGIAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4Z5</accession>
    <name>A0A0D2B4Z5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08961</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233986.1">
        <property type="nucleotide sequence ID" value="XM_016383283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4Z5"/>
    <dbReference type="GeneID" id="27336044"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08961"/>
    <dbReference type="HOGENOM" id="CLU_008455_1_1_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF135">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="63"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="499" mass="53631" checksum="E44814C0157E5BD0" modified="2015-04-29" version="1">MSADLGSAHEKPGLLEDGQQTQHSSKPDQSSEAIGQETKDNIVDWDGPDDPQNPRNWPAWKRMVQVVFASAFLLAANLAATMFAPGAAALAKEFNITSSTIITLTVSIYLCGFAVGPMLIAPLSELYGRLVVYHTCNVFYIGFIIGCALAKNTGMFLTFRFLAGSAASGPLTVGGGTVADVIPPAQRGKAMSLFVVGPLLGPVLGPIVGGFVSDSIGWRWTFWIITILAGVSFATSIFFLRETNAAVLLEWKAARLRKETVNTALVSKMDRGLPPRELFIRAITRPTKLLVLSPIVLLLSLLCAFIFGLLFLLFTTFPAVFEEQYHFSASVSGLSYLGVGIGMGVSLGTFATVSDKLHKSLGDAPKPEERLKPVMWVLPAVPIGIFWYGWAAEKQTHWIVPIIGTSLFGFGVIWVLMPVQLYMVDAFGPEAAASALAANVVVRLLCAAFLPLAGPSLYANLGLGVGNTVLGAIGVAFLPVPLLFYRYGGWLRERFAVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B518</accession>
    <name>A0A0D2B518_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234199.1">
        <property type="nucleotide sequence ID" value="XM_016381097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B518"/>
    <dbReference type="STRING" id="91928.A0A0D2B518"/>
    <dbReference type="GeneID" id="27333847"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06764"/>
    <dbReference type="HOGENOM" id="CLU_021529_2_0_1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="54047" checksum="458A4BD44988996D" modified="2015-04-29" version="1">MSNYQDPEQVYDLERDFLAPARSPGLKPVNINYKPVVTPPPLVPNYPSSDSSDEDEACEDGPSGRQRTSRKSRTDPSLSDGTLIRSLDPNQVELARFAEKHALASGSEEEEEEEGNQAETGETRMMIQHIAAQNNASARANIAEECLLNDNDGDFPMIDSPRGVHDGGQALHPPVSRDTYGCDGLPQTQQGLTPRKHEKQPERGEITIQYRPAPPLAKELLPLDHGNPYRDRHDSLITSPALGKYAMTPRFPDPDVILPAIQKSPPRFSPASSPQHTQTLPPLRTHLGGYEANSPGFTGVSPLMGRPSPGLMLSLGPSPPFHPPMHASAMSPPAIPVQFSSWRSTTRDSSISGSSEPTPPSSGAASTPTSSIVMVQSPAAVMSVQNLAPIQNGKRSSVSDTHPIDSSARTASDAQPTSEEEEEDGERKLSNDLPAMSQLTADGSYQCLYPGCTASPFHTQYLLNSHMNVHSETRTHFCHVAGCPHGPGGKGFKRKNEMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B557</accession>
    <name>A0A0D2B557_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234056.1">
        <property type="nucleotide sequence ID" value="XM_016380954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B557"/>
    <dbReference type="GeneID" id="27333703"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06620"/>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF6">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="633" mass="70674" checksum="0B94FA076E1F022B" modified="2015-04-29" version="1">MASTIEATFAAPSPSDTASLRSSFDVLETPLTEIEVEDTPSVTFPERPVKVIIVGAGIGGISAAVLLSHKVNNLTYTVYDRNAKVGGTWAENTYPGVRCDVPSHVYQLTFAPNTDWTEYYSPGSEIQQYYQRVAEEYGVKPNLRLSHEVLSARWLTQEHEWAIEVKDLASGNIFTDRANFFVSAPGRVNQPYYPDLKGLEEFKGTVIHTARWNANVDLRNKHVAVIGNGASGQQILPNILPEVAHIDHYVRSKTYVSPTFRQGLIEASQELPGGHIYSEEEKKSFRDHPEKYLAYRKDLDKTHYGGVNNRFATIGSEANQKLRESLLSGMLQRLKGDKEWLARLTPDYAPGCKRLTPAPGYLEALIGPKVEFVDTSIARVTATGLETEDGNVRNVDVIILATGFRDGFYPRFPTIDEKGQDLSQAWRPGGEIGFPETYLGIMAPRMPNYFFVLQAQGNAFGGTVPYQCEISATYIARVIRKVQRHGYKAIRPSPRAAQEFSVVVDRYFENSVINDGCRTYFKLGGNTGKARNVIGFPGTTRQRLEVLSEPRWEDFVFADPRDGDEFGPDVDAAAGTTTAATMTLDDLEKNNRFLRFWGDGRTALDRANNLDAMTDYLTEVGKVDLRRLHEEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5U7</accession>
    <name>A0A0D2B5U7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_06801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234236.1">
        <property type="nucleotide sequence ID" value="XM_016381134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5U7"/>
    <dbReference type="STRING" id="91928.A0A0D2B5U7"/>
    <dbReference type="GeneID" id="27333884"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06801"/>
    <dbReference type="HOGENOM" id="CLU_006762_2_1_1"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000403">
        <property type="entry name" value="General transcriptional repressor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="408"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="632"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="743"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW14020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="800" mass="89838" checksum="216681147A73B149" modified="2015-04-29" version="1">MALVPHPSPPGVLGLQPPHLGQYNGAAPVDAHMQRQRLLSQLNESTWQRIGSLNELLGDHEGALFAYEQALRHNQWSPQTLNAISCILRTKEKYPEAMEYLKNILKVEPANGEAWGNLGHCYLMMDNLQEAYTAYQQALYYLPDPKEPKLWYGIGILYDRYGSLEHAEEAFSQVMRMQPDFEKANEIYFRLGIIYKQQQKFQQSLECFKYIVNDPPRPLNEEDIWFQIGHVYEQQKDFEAAKAAYRRVLERDPKHAKVLQQLGWLHHQQNQNYASQEQAIEYLEQSVSSDNQDAQSWYLLGRCYMAQQKFPKAYEAYQQAVYRDGRNPTFWCSIGVLYYQINQYRDALDAYSRAIRLNPYISEVWYDLGTLYESCNNQTSDALDAYSRAAELDPTNTHIKARLALLRSGQPTGPNQQNAPVPQDVHPQAYQNGVGVPPGPQWGGPSSSSQQSQPPPVDPGRVHDWTRGLAGIQQPPSQANGFDNRDSMRAPPPRAPSPRNEPPRPYDSARHTPSRKAQSPSPKLQPGMYPPGPQTLPQISMQDRGPGFGPGVRPSPTMNGAPLPPANGATSNNTLPPYGRPFSPPSELRPIRDERPPSPGSAFRPQPFQSGPFPSIANGVPSAAPPLPSAEPPREERPSSAMKRTRDWEPEGPSKKIASDETRARLDDPSRRNSPPGRLPSPKGHFRRSSSEVRRENERRANENYHPSEAAHHPYSLAPQPQTEPQSQPPPQQIPSMQTFLDGPKEDRPEHVEQAARKVEVDEDYDNNSEDDKRVATVATNSPQVAAPPPSTASKQEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7F2</accession>
    <name>A0A0D2B7F2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235069.1">
        <property type="nucleotide sequence ID" value="XM_016381967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7F2"/>
    <dbReference type="GeneID" id="27334721"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07638"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="61"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="526" mass="57901" checksum="B964191DD3A6ECB2" modified="2015-04-29" version="1">MSRDIEKTDTREQLEDLSALKHVDTVHDDQALKIIAAYQGADAEWTPEEEQKLVRKIDFKLVPLMFITYGLIYYDKSMLSSAALFGLRKDLALTGNRYSMSSSIFYLGAIAGALPAALLAQRFPVERVAAGLICLWGLNIILTIECTDFKTLYVNRFFLGFLEAGLSPMLMIIVASFYKKTEQPLRLGSWWSAAGFISMFAPLVNYGFGHVKAALSPWKYMYIFAGSLTVVWGIVILLFLPPEPIHAKGFTERERYIAVARLRVNNAGIRNSHLKPAQVLEALTDIKFWLVFFCAFCIMIANGPLSTYLPIIIAGFGYSPLNSLLLTMPAGFVAGTCTLLSTYLAGKLSRRGGRSYVVVLFQFLVILGALLMWRLPHSNKAGGLAGLYLLASFAAPYGVIMSLQAANTAGYTKKTVTSSGLFMGYCLGNFAGPLLFRPQDAPQYEPGWQAVVITAFIALGLIVAYRFVCVLYNKKRNEAGIAEGVDHAFEDDLTDLKVTSCPNSTSYSAAADNSFRRTSSSATRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8N8</accession>
    <name>A0A0D2B8N8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235524.1">
        <property type="nucleotide sequence ID" value="XM_016379697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8N8"/>
    <dbReference type="GeneID" id="27332436"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05353"/>
    <dbReference type="HOGENOM" id="CLU_1627066_0_0_1"/>
    <dbReference type="OrthoDB" id="3246050at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="1">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="163" mass="17901" checksum="040D46C104FCBADE" modified="2015-04-29" version="1">MQSSRSFSFSRAVPGEVPMSKAIACLHEPSNFIGLSPYVISYHLAPSTEPSSTAVSKNYVISDRVNYLPFGLWTGQIDVPVTYTNQEDGVEVVKKPPVGITVLERWTLQPPTISNPQHPNVAELVLRAELHGNSVTLCMVEGIMKKSLESYIDGMVKVLQALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9B0</accession>
    <name>A0A0D2B9B0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235461.1">
        <property type="nucleotide sequence ID" value="XM_016379634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9B0"/>
    <dbReference type="STRING" id="91928.A0A0D2B9B0"/>
    <dbReference type="GeneID" id="27332373"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05290"/>
    <dbReference type="HOGENOM" id="CLU_011017_2_2_1"/>
    <dbReference type="OrthoDB" id="4898046at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="178"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="542" mass="61124" checksum="9D8FFD2966A5680D" modified="2015-04-29" version="1">MDSTNSNEDAGFANGDDHAEKSITLIVSASTARSLYVRGSIRIVPRGGVKHKQGQGLIDPRIETYFEDVHACFPIIHQPTFRASLPDLLGTGQQQPRLPLDQGLLIYSMMALSSRFSRLPEFRDVPLTQRGRGFAHQSGKIISQLLMESELDKASLTFLHGCSLAAAYWLACAPNGKSWFLVGICVRMAYGLSLHTTDVDLRDSEAQSLTSTEWARRESLRRAWWMVVECDNFASVLRCRPLSIDRSRMHVLLPCNDEFWFSETPCTSAFLDNDAQRSWKDLKCSSNKNPHAWYLLVNQLMIRGHEMSLNSRRSITDQKNLRNLIQAVDMGLPEEFSRTRHSAATFEEGSIDHDNWVVALHLMLQVAHAYIFESEEQEEDEDATLEGEDKSPVSSESGRGNPPHHPFFEGGKRPPLQVAPQKFRPTLNAMLRVIRTWPPDYCINCQPWIVCALIGPQASHLQATFFAPTPSRGALERDLIRETIGRMAKYWDVASVTLELMDTLTSWLSSRLQSDDTTTTATTRSPITDLEPDHKLRCLLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9D2</accession>
    <name>A0A0D2B9D2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carotenoid oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235481.1">
        <property type="nucleotide sequence ID" value="XM_016379654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9D2"/>
    <dbReference type="STRING" id="91928.A0A0D2B9D2"/>
    <dbReference type="GeneID" id="27332393"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05310"/>
    <dbReference type="HOGENOM" id="CLU_016472_4_0_1"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="71843" checksum="0BB05AC4C39046AF" modified="2015-04-29" version="1">MTPVSKAAKRNRARPHPYLSGNFAPVHKTVPLTPCVYTGAIPDELVGGEYVRNGGNPVSNEDLGRDAHWFDGDGMLSGVAFTRTTNGVQPEFVNQYVLTDIFLSTIASQRLRTPLLPSIATLVNPLSPLYKIIVLVFRAIFFVILSWLPGSVQVIKKISVANTAIIFHDGRALATCESGPPMRVSLPSLETIGWYNGKRAEGEPGGEQGPGFGGEGILGFMREWTTAHPRVDSRTGELILFHATFAPPYVHYSIIPSTHKPIVSTTPLERPTRLLNAPIPGITSAKMMHDFGVSFNHTIIMDLPLSLDPLNLAKNTPVVAYDPMSKSRFGIFPRNSPELIRWFETKACCIFHTANTWDDQVTNKETGRVDTISVNMLASRLTSASLVFSAGNIAVPQPTTLNGTDEEDQCRLYYYQFGMDDFKCNRINYQFALSAIPFEFPSVNEEYVMGRVRYIYGCSTSEGSFGAALGRAVKIDCLVKIDAETLISRGKKDPSLVSVTGCVDKRSLSDIISSGNTRDDPVSVFKLPQGWYAQEPRFVARHNGESEDDGWLLTYVFDESQLDAEGECRPDAISELWIIDARDMTTIVARIQLTQRVTYGLHGSFITEDQIKTQRPIETIRGIKELDHLRSEAGLWSRVRQSVERLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9I0</accession>
    <name>A0A0D2B9I0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235814.1">
        <property type="nucleotide sequence ID" value="XM_016379987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9I0"/>
    <dbReference type="GeneID" id="27332729"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05646"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="265" mass="28303" checksum="6C7A6A5940C3EE42" modified="2015-04-29" version="1">MAGNSQNTTYVVLGANKGIGLGLVQALLARPQTTVVGVVRDPVRASHLEEQCSSVPKGEGSILHALAVDVSRSPGRDDLKDFIKTKLPSSIGHVDAFISSIGHTGVMKPALETTAEEMRDHYEVNTIAPLMLFQAFWPLMEASTESGASSTPKKVFFLSSSVGCIGDWMEPIPGGAYGPSKAALNWIVRKLHFELQDKGIVSVAVHPGWVQTEMGDMAAKSWNYPGKPPLTVAQSVEGVLGVIDGASRENSSGKFLSYDGKEVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9U3</accession>
    <name>A0A0D2B9U3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235611.1">
        <property type="nucleotide sequence ID" value="XM_016379784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9U3"/>
    <dbReference type="STRING" id="91928.A0A0D2B9U3"/>
    <dbReference type="GeneID" id="27332524"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05441"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="178"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="341" mass="38200" checksum="5A5E2BA1D25A2CDB" modified="2015-04-29" version="1">MAIAEAPPILNFSSFYGDDEEAKARLIAQVRKCCLHNGFFQIVGHNVPAELQEAVLECVKKFFSLPQEDKELVLKEKNTWNRGYEKIGSQILEAGTAPDLKEGFYIGEEIPTDHPYFVHKRLNSGPNFWPETMEGVEEFKATCTSYYKAMHALARDVLVVIAQTLDLDASFFKDFTTDAVATLRFLHYPPQPPDSDEKISRGIGAHTDFGSVTLLMQDEVDGLQVYEKSTDEWLDVVPVKGAYVVNLGDMFQRWSNDLYVSNTHRVINKSGKERYSIPFFYSGNPDYVIECLPNCRREGESSKYPPDSVEGIVGGSYKKSYGAAEAFKKTTPTAAPTAISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBZ3</accession>
    <name>A0A0D2BBZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236709.1">
        <property type="nucleotide sequence ID" value="XM_016380882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBZ3"/>
    <dbReference type="STRING" id="91928.A0A0D2BBZ3"/>
    <dbReference type="GeneID" id="27333631"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06548"/>
    <dbReference type="HOGENOM" id="CLU_877271_0_0_1"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047974">
        <property type="term" value="F:guanosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF161">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="96"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="312" mass="33701" checksum="CE401BB14778FA7E" modified="2015-04-29" version="1">MSYQSFLKATSNSKPAIQTPSPSSIQRKPPVSASPTPSSVHSATTHNPSLSLTSNPPFTPASSAPSPTTTSKPLAQPEPSQAVQAAQTSLQPLTKAQIDAALETCLSLQNTATKYHEKRPFAALLLGPDNSTVLLTHYSISHVQHAETELARLASIHFSQPFLAGCTLVSTWEPCAMCTGTLYWSNIGRLVYAASEEKLNELTGGGNDENMTMSLPCRDVLKAGQKDVKVIGPVSGWEERVIAESGKWWRDHQSTENGQHLRAASVNGSEKPESVSSVRQGTPTTWTGEDSVLSRIDDEGEYKADLDIDWMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCR1</accession>
    <name>A0A0D2BCR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_03953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236979.1">
        <property type="nucleotide sequence ID" value="XM_016378302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCR1"/>
    <dbReference type="STRING" id="91928.A0A0D2BCR1"/>
    <dbReference type="GeneID" id="27331036"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03953"/>
    <dbReference type="HOGENOM" id="CLU_006632_5_0_1"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="635" mass="70665" checksum="7DBF48B7672A966B" modified="2015-04-29" version="1">MASPAAVSSDIGPARKYRSRKQKPCDNCRRRRVCCVRDAEGACALCSRRSIPCTFSSNPSPRKRPARTTTTATDPFPRAEPGSIPDESPQRIANPRFVGNPSQPTSSTTHSGHKGGVEGKYIGLTGTEDVYFVADRLQGLGNDPAREAYFRERSASAQSYSSGTSNHHHVGSIEPSLPLVRSIFFERSHPAYPLLEARLAQSEKQSRLLAIAIAIITKYTSPELAGLDNNVLIEEFTSSLLLEARSPTLETVEAAILFTQRALRGKMSTSAPGMWAVIGTIVGMSHDLGLNIDCSMWSIPAAAKRRRRRIWWAVYMQDKWFALALGRPSYLDDANTTTLMLTAADFEDCKPDSAEDQLERPELVTGIHCFVAMAELTVILKEVLAVFFTLSSVVRLREATGEHICDIADRIEAKLENWRATFLDQVLTQRTFPDVTGSLEIAFLTVRVMLLRGIFPKLYRRNLPLDVQVNRGVDITSRAITLVETLQINRLSAFWWSYSGFNFTLIGTCMASLKRLSADTIRARYWDERLAYYHKLLAAHGVSFWPAKFAATALGLMAKNLRKSTDVAPEDAHEDGPSLIDESTDGLMNAFTSPETSWSGFSYDFFPHNLTEHLNDADFSTDWTSIGKPDGFQWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDE3</accession>
    <name>A0A0D2BDE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_04149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237174.1">
        <property type="nucleotide sequence ID" value="XM_016378497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDE3"/>
    <dbReference type="GeneID" id="27331232"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04149"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="77"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW16958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="547" mass="60531" checksum="034BDA160E435C35" modified="2015-04-29" version="1">MESKSADYLDGAAVVSPQHHTKEMDTKAADHLEELGVVSPKTQYWSEVTQDAKEATAAEHSTTFWQGIKLYRKAAFWSFIVSMTIIMEGYDTALLGNFYALPAFKEEYGTLSKGSYQISSPWMNMLSYLQMITNIIAAQAAGSLSQRFGYRPLLLAALVLMGGAIFITFFAPSLPVLLVGELLCGVPWGVFAVLAPAYASEVCPVVLRGYLTAYLNLCWVIGQLINAGVVYGLQDYPGEWSYRIPFAIQWVWVLPLFCLIFLAPESPWWYVRKGRLEDAERSLQRLSENSDAVNIKQTVAMMLHTDNFEKEQESGTAIIDCFKGSNLRRTEIACAVYAMQPMTGGGQIPSSYFFEQVGLSTRQSFGMGLGATGVAFCTTILAWVVIGLTGRRRMLLGGMSGMVIVLLIIGFLGLGPTSNHAIGWAQAALALFFNVFYNLSVGTLAFTIFSEVSSTRLRGRTIALAKNVNAASSIVVGVASPYFINPHNLDWKGKVGFFWAGVNILWMGWAYFRLPEFKGRTYEEIDILFTKKVKARDFKKTVVDLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEA8</accession>
    <name>A0A0D2BEA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_12013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847503">
        <property type="protein sequence ID" value="KIW09729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229945.1">
        <property type="nucleotide sequence ID" value="XM_016386320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEA8"/>
    <dbReference type="STRING" id="91928.A0A0D2BEA8"/>
    <dbReference type="GeneID" id="27339096"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12013"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF317">
        <property type="entry name" value="ADENYLATE-FORMING ENZYME AFEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="35"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="445"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW09729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="61158" checksum="2BF0CA4DB39710E0" modified="2015-04-29" version="1">MSTSVPIAPRPQEVIIPSTDVLTFAFDRPGLFEKDQQVFVDAKDPSKRISWYQAYYIIRRLVKGFKEKGLQEQDVVCCHMYNNIWYPLIWLGIIGAGGCVLGTNPGYTPSELSHIFKLTNPKFVVSQVQCSDPVLEVSSHGSLAADHIFLIDLESERDPKGCRSWEDLLRCGEDDWERPEPSQIAAYAMTSGTTGLPKAAMLSHRSIVSQTATLENEFRAKTYVPRQLIFLPIFHAFAMPLAMLLPLRLGIPTYFLPRFDLADFTRAVGRFTITDVAIVPSIASSVASIPLSERYLLLSLRHLISAAAPMSAAVQNHLYNVLSPNAVISQCWGSTETGWITLFSWREKDDTGSVGHLLPNVRMKVDRSPVSTLFSTEGNPGEGLIHSPSMFSGYLNDVDASQAAIDREGFFRTGDLVYLRAGKVFYAGRMKETIKVKGWQVSPTEIESILSRHPLISDVAVAGVASEDESGLVDTLLRAYVVRQRPSDSDAQGWPRLTEEHVEEFVKSQLISYKQLTGGVVFVTKIPRSSTGKILRVLLEQAEIDTDVTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF00</accession>
    <name>A0A0D2BF00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230150.1">
        <property type="nucleotide sequence ID" value="XM_016386018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BF00"/>
    <dbReference type="STRING" id="91928.A0A0D2BF00"/>
    <dbReference type="GeneID" id="27338793"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11710"/>
    <dbReference type="HOGENOM" id="CLU_449068_0_0_1"/>
    <dbReference type="OrthoDB" id="3563678at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057230">
        <property type="entry name" value="DUF7908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25485">
        <property type="entry name" value="DUF7908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7908" evidence="3">
        <location>
            <begin position="11"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="546"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW09934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="63610" checksum="ED1533169F97AD89" modified="2015-04-29" version="1">MTSATTTSSPFPSGFVMEVTALSQTKRRRAETQGYVSFGDEDQAGLTDSKSSASIFFLYGDFLVTDDEYVGSRSDSKDSPLIKSGTPPTGFQFWTFPAGLGEVEGAGGFCLLGSTVYVVIDQSTCEYPINLVQRAPPAVSTSSTTTTATSQPTSSVVSTTTEATTSTSASTASTSETATSTLATSSSETTSSTSSQVTSSSETSTSTSTQSSSTYASTTSSETSTATSSQTTTSGEATTTASTSESTTSTQASSTTESTTSSSSSETTTVTTMTTTTSTQTTTTTSATPTSTVIPGYCEVGEYQFSTEDYDYYVCPDSDVHGYDLFYTSQDTYEGCAAQCDTYESCAGWSTPIVDGTGLCNLKTVTDASTRSESDTYNMWFKIAKPPTSTTTTSTTMSTTTTTTTMTTTTTTANNSPTCTAMSNPYTATNSDKFDLQCNTQTGGTQIGAVQNSDSFADCMELCAGVAECQYAQYQFTELPADPPLQPDPETVQTCTLYSDSNGSQGSAGFDLGHKLQPVTGTCTDQSDPFTTSSGVQFNTLCGQDWNGNYLNIGPAADYGACAEICGQDSECIGFLYNSGTCYPISGGMSHNSYYDGPDFNSGVKYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF96</accession>
    <name>A0A0D2BF96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VanZ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237879.1">
        <property type="nucleotide sequence ID" value="XM_016379202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BF96"/>
    <dbReference type="GeneID" id="27331941"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04858"/>
    <dbReference type="HOGENOM" id="CLU_096870_0_0_1"/>
    <dbReference type="OrthoDB" id="63581at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037970">
        <property type="entry name" value="vanZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26636" checksum="AEE13A4278F889B2" modified="2015-04-29" version="1">MRIRFSFASKSTNPVYPSRLLTCSTVAFIILLLFASSLGLLPHSSLPSTPAAAQPYIPAQSDKAVHFLVFFALTATFYFILDTSRRRVIHLTLIVCTLSLGVGSEVAQGLLPNDREFDAWDVLANVIGSLAALGLCSAYHRRSAERRRMAKYSALPTDGVEGEDLELGERSGGDELGRPSRSADDGQETGVVARSVEDELDNWDENAPDEQWDEDDDVTTSQHTKATPSTSSVGSEEPSKKKAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFE0</accession>
    <name>A0A0D2BFE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237934.1">
        <property type="nucleotide sequence ID" value="XM_016379257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFE0"/>
    <dbReference type="GeneID" id="27331996"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04913"/>
    <dbReference type="HOGENOM" id="CLU_2176975_0_0_1"/>
    <dbReference type="OrthoDB" id="4156595at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12431" checksum="ED140585F8BBEC22" modified="2015-04-29" version="1">MSAKTATTIPEEFIRESFYTRFIVAPVLFVSFLISLFFIDRQTAGGIFGQSNSKHAYYHSHQRKLAKKEMDEAFQLRRKVILALCVLSAVVLAFVAWGIEWTVWKVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFH4</accession>
    <name>A0A0D2BFH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_04953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237974.1">
        <property type="nucleotide sequence ID" value="XM_016379297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFH4"/>
    <dbReference type="STRING" id="91928.A0A0D2BFH4"/>
    <dbReference type="GeneID" id="27332036"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04953"/>
    <dbReference type="HOGENOM" id="CLU_011409_2_2_1"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="618" mass="70364" checksum="D80042E52DDC5143" modified="2015-04-29" version="1">MATVTLVEEVPEVEKAKRTRRTHNKVRTGCLTCKIRRKKCDEEKPFCRRCTSTGRKCDGYAQEPSPPTSHEDSPTSTCEPDPKRQRTSINTKVAIPSLSKPTKARVVVDEERSVLSRPPSNVMFENDNDFFCFDFFRSRTGPEFAAYFDSSIWRTYVTKAAFQHPTVLAAASAVGAVHRRFELGISREAFEYCDFSDKLYQKALRMLSRDMASEVPNAAEINMVTLKLFSLFETFQGNYDTAQLHLTNGLKGLLRRNMRTTYKDTQYRTVDLNYESLRRLFLKLELESVRLFGGLATILSDPEDAVPPPSLDPFDPESLAYLPDPNPYTIPRGFTSLSQARDVLFTETKWIWHTWTLLEQGDLTGTGFSRHHAHISRLLQWSMAYAEFSKTERNRRESSAQEKHAGHLLKAYREASYLLLLTQMAFHSPETGEVIVPLCDPPETCNCHRSCRTYAERREALNAHFARILVLCESIFNRGSFFAYEEHSISVDSGIGPPLYLGSARCRSTKVRHQVTSLLEESEIQKRVWDKLGVYSIAEKLSSIEEHAVVDCGAIPAELEPKWVDITFFLDERRALLRYCTPDREGIGGKLRGTGLVTERYMGSGSGGLVWTQEWISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFJ1</accession>
    <name>A0A0D2BFJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237591.1">
        <property type="nucleotide sequence ID" value="XM_016378914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFJ1"/>
    <dbReference type="STRING" id="91928.A0A0D2BFJ1"/>
    <dbReference type="GeneID" id="27331652"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04569"/>
    <dbReference type="HOGENOM" id="CLU_014181_0_0_1"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="480" mass="51634" checksum="02535B5EE5D983DE" modified="2015-04-29" version="1">MEIHSVLPEERVRDPKGDTLPWGYRYPDSARNVRQPEESGPFGRNRSLRTTGSRTPRARTGTTPVRQKENTAVAEFGRLFAREQAKEEERTKTTAGGTGTGTTGSTVDTTRIGEPEAVPTECLLYGYAGKRSEWKVLSKFESVVSPGYIVEDYPREDTTLFLSSNSPMGRLGSPSVVARRENLSREAIRKSRIYSGGAHWIKVTFDSYQAAERACFYSPLEIDGYMVHCEMWQGKGPGADVALPRGPAGQEHVGAGLLATGEGAGLNQGGRARTFSAATGRDSALAGFERAMQTLPRGHTVQDTQYGQPEDESASSTTASSATATAVDHHDHQLEPLLSPTIGSSSTSSLRSRSVPNLASQDITSHQPGRSEYMTHIKVKKAVLRPISEALPPQPSFAERAIRGIPVVGSLVGGGAGGGGGVAANNKQVGLHPTAGTLLGVEGPLIREDGSWDPANGWYWSFWRRIDDCFGTDMCGIKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BG41</accession>
    <name>A0A0D2BG41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237781.1">
        <property type="nucleotide sequence ID" value="XM_016379104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BG41"/>
    <dbReference type="STRING" id="91928.A0A0D2BG41"/>
    <dbReference type="GeneID" id="27331843"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04760"/>
    <dbReference type="HOGENOM" id="CLU_073626_0_1_1"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="162" mass="18556" checksum="9BBC54A0995EDAF3" modified="2015-04-29" version="1">MATELTVQSERAYQKQPHIFLNHKSKAAKSRRVGKGGRRWYKDVGLGFRTPKTAIEGVYIDKKCPFTGQVSIRGRILTGTVVSTKMHRTLIIRREYLHFVPKYARYEKRHTNLAAHVSPAFRVEEGDTVTVGQCRPLSKTVRFNVLRVLPRTGKAVKAFQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHS6</accession>
    <name>A0A0D2BHS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231145.1">
        <property type="nucleotide sequence ID" value="XM_016384543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHS6"/>
    <dbReference type="STRING" id="91928.A0A0D2BHS6"/>
    <dbReference type="GeneID" id="27337311"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10228"/>
    <dbReference type="HOGENOM" id="CLU_055859_4_2_1"/>
    <dbReference type="OrthoDB" id="4158266at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="269" mass="27683" checksum="C035A6EAE238A2B0" modified="2015-04-29" version="1">MQDGTDFYYRGTCTDRTWNSQQCPGWCFAQNSNSSIPLAKCDTEQDWYCCPGDADCSCETGKNAVKLGGEQPSTITVIGSTSWPGYTSTTSPFTASNLVTDGTQTATGTSNQAAATTATAADSNTNTPATISSNTATAEPASASTVIPATSSGGGSSNTGLAAGLGAGLGAAAVLIGVLIFYLVRNRRRKNAVNAGGNAAYGGIPSSAATMQKPVYSDSQQSAPYSDNTNPQSQPELPGQGEHDRAEMATISQGQTTYQHQQRAELDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHT8</accession>
    <name>A0A0D2BHT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238704.1">
        <property type="nucleotide sequence ID" value="XM_016377134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHT8"/>
    <dbReference type="STRING" id="91928.A0A0D2BHT8"/>
    <dbReference type="GeneID" id="27329859"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02776"/>
    <dbReference type="HOGENOM" id="CLU_010194_13_3_1"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF31">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="309" mass="32880" checksum="B3286E5BBEC23E2E" modified="2015-04-29" version="1">MVVKPLAQVDPSKLKGASVLITGAASGLGKSTATFFAQSGALVTIADLQDRSSFAAELTRQGHTAQFVRCDVTDWGSQVAAFQAALRFSPTRTLDVVAAFAGVDGNINVFEHILETEASVDGQPPAVPSVAPIDVNLKGAYFTSILALHYFRLKAPDGTVPVSTITKSLTIVASLSGYIDEDHNVTYSASKFGSRGLFRTIRAKAYDQFHVRVNAIAPWAMRTPMTEAMLEGIAELGIVHGKGITVVEHEVLTQALTTIAVDDTIRGRSFAIVPEGAVDLGDDIDGNYGGTRLVELMALRKEAGDIIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIB0</accession>
    <name>A0A0D2BIB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238566.1">
        <property type="nucleotide sequence ID" value="XM_016376996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIB0"/>
    <dbReference type="STRING" id="91928.A0A0D2BIB0"/>
    <dbReference type="GeneID" id="27329721"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02638"/>
    <dbReference type="HOGENOM" id="CLU_046066_1_0_1"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF13">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="15"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="262" mass="28390" checksum="96EE0DD534D1D7B0" modified="2015-04-29" version="1">MVQNLNVSAGPAPTVVIIPGSFSSAYFYDEIVHQLRMNGFEAAAYDLPSASRMPPQPAATLANDAAFFHDIAQKIADQGKDIVFVTHSYGGVVGTEASKGLTKAERQADGKEGGLVRLVYLTSVVPSVGNSLADTMGDLVPTYLKVEGEYMRHDPPEESAKLTFSDLPPEVGVDWVKKMPLHSAPSFAGKLTHPGYKYVPVSWIFCEDDLILVPEFQRNCIEMIERESGNKVEVHNLKAGHCPNASVGVETAMLITRAIKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIF7</accession>
    <name>A0A0D2BIF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Arsenical-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_10444</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231360.1">
        <property type="nucleotide sequence ID" value="XM_016384758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIF7"/>
    <dbReference type="STRING" id="91928.A0A0D2BIF7"/>
    <dbReference type="GeneID" id="27337527"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10444"/>
    <dbReference type="HOGENOM" id="CLU_022869_0_0_1"/>
    <dbReference type="OrthoDB" id="187348at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW11144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="385" mass="42313" checksum="24BB3C7E6457F367" modified="2015-04-29" version="1">MSHSREDPGTLDDQNTGRHTPGLATNVDAEKQQSQGRVKQKKSAYAGLGWLDRLLVLWILLAMIVGILLGNFVDGVGPALQKGKFVDVSVPIAVGLLVMMYPILCKVKYETLHRIFGHRQIWIQLGFSVVANWIIAPVLMLGLSWTFLPDRPELRNGLIFVGLARCIAMVLIWTGLAGGDEEYCAILVAFNSVLQMVLYAPLAILFVNVISHGESFEVAYATVARSVGVFLGIPLGAAITTRLILRNINATWYDRKFLQWIAPWSLLGLLYTILVLFASQGEQVVHQVVSVVRVAAPLIVYFVVIFFLTLLITKRIGFGYKLAATQSFTAASNNFELAIAVAVATFGATSDEALATTVGPLIEVPVLISLVYVARWIAGRWNWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ16</accession>
    <name>A0A0D2BJ16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238771.1">
        <property type="nucleotide sequence ID" value="XM_016377201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ16"/>
    <dbReference type="GeneID" id="27329926"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02843"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="551" mass="61346" checksum="D72A5063E920568F" modified="2015-04-29" version="1">MAAVKDGSGGVHIEASDTGLEHLKDVGLRDATLASGALEGTAQEHSMGVFQALKTYKRAAFWSILISTTVVMEGYDVTLIGSFFGYPTFRRKYGAYLNEESGYQISATWQQRFNCLGALANIIGALFNGWATARWGHRRVLMFSLFWLTGFIFIVFFAPTIEVMLLGSFFCGIPWGVFATTGPSYAAEVTPLAIRGYLTAYVNLCWCIGQFISAGVLKGLVNNDTPWSYRVPFAVQWIWPVPLFIAAYLAPESPWYFVRTDRIEAARKSLERLTEPEHHGDIDPTLAMMVHTNKLEMQERAGVTLWDAFRGTNRRRTEIACMGFLSQITNGGALCYSGSFFFQQTGISASAAYAISLGGTGIAFVGTVISWLYIYRWGRRTIWLVGFSFLVVILWTIGFLALPHHQTKSLAWAQSLLCIVWLGAYSMSVGPIIYTLVSEIGSTRLRTQTVVLARSTYYVGNIICGGLLQPKLISPGAWNAKGKTAFFWAGLATLTLVWGYFRLFETKDRTFGELDFMFQNDVPARKSAKYQIREEELYTADGDGDVQKKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKD0</accession>
    <name>A0A0D2BKD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239216.1">
        <property type="nucleotide sequence ID" value="XM_016377646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKD0"/>
    <dbReference type="STRING" id="91928.A0A0D2BKD0"/>
    <dbReference type="GeneID" id="27330373"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03290"/>
    <dbReference type="HOGENOM" id="CLU_007727_8_3_1"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10001">
        <property type="entry name" value="HDAC_classII_APAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF17">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="367" mass="40310" checksum="F4AA3303ECDBF8CD" modified="2015-04-29" version="1">MLAILYDPDCLLHKTVEILGSKLIPALESPARLEAILKALHLSDYAVRTLHFSSLDDEARTRRLLSLTSQTHQHDYLVHLQTVFEEWLSAGLIEKDGNVVPECFYLPTSTGKPMRAPRDTFARAGYYAFDMSSGIMSESYRAIVASANLAYEGADMLTGDNASTSSPPYIDAVLALCRPPGHHCDGRRAGGYCYINNAALAVSTWRTKNADAKVGILDVDFHHGNGTQEIFYADPDVLYVSIHGEDEFPYYTGAEDERGLGAAEGTNVNLPLKVGSSIDEYLEKLDHALSRLVAYGPGFLVVSLGFDTYHADPLGSFQIHTEDYETIARKTRQSLKGVPALILLEGGYVIEELGNNVLSFLKGWKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKY5</accession>
    <name>A0A0D2BKY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239481.1">
        <property type="nucleotide sequence ID" value="XM_016377911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKY5"/>
    <dbReference type="STRING" id="91928.A0A0D2BKY5"/>
    <dbReference type="GeneID" id="27330642"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03559"/>
    <dbReference type="HOGENOM" id="CLU_068979_13_0_1"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="6"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="234" mass="25621" checksum="3509A6779C08F332" modified="2015-04-29" version="1">MSFRPALIVVDMQNDFCPPDGSLAVAGARDIIPLINRLLGSSKFVIKVATQDWHPRDHISFATNHPPPNNKPFESFVDVRNLVANKPEQTMKQRLWPVHCLQQTKGAEILEEIDLSKVDAIVYKGMDSRVEMYSAFSDSFGNMTAGAGGVNVDLAALLTEQQITHVYVVGLAGDYCVKESALGAARAGFTTYLIEEAQKCVDPSSWSDIKAELSQGSVSLINIDSHESQRVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLN2</accession>
    <name>A0A0D2BLN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII28-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232295.1">
        <property type="nucleotide sequence ID" value="XM_016383672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLN2"/>
    <dbReference type="STRING" id="91928.A0A0D2BLN2"/>
    <dbReference type="GeneID" id="27336436"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09353"/>
    <dbReference type="HOGENOM" id="CLU_035243_0_1_1"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="176"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="373" mass="40730" checksum="26E2E9AB6EE06E39" modified="2015-04-29" version="1">MASSPPAPFPTSLPNPKKRPSMSSQASGQGGSSKRPKLHPLRQTSFPAQDARLNSAVTSARSETGSIANSAISGVSGKVPGRGRGRPRKSAQLNADEVRSSHQPPADSASQVEGGSARSAGRGTKSVASGAGGGADADAEEEDEVEIDGMLENMDEQERRQAEEEEIRQEQRRERLADTLDPDQYSRYNQWRALSLNNATVKRLVNSIVSQSVTSAPLQAVRIYGKWFVGEIVERAREVQEEYAKAYDVTRQAEKERRQKELETLEEKQKEKQAQIQANNNAGPGGGRATPDMQSRMLTRDIERLRREIKEYIPNPHRGGLLPDHLREALRRYKADGEGGGVGFQGMSHGLLGVPGSVAWRVGDGASGRRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMV0</accession>
    <name>A0A0D2BMV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b-c1 complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240489.1">
        <property type="nucleotide sequence ID" value="XM_016375213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMV0"/>
    <dbReference type="STRING" id="91928.A0A0D2BMV0"/>
    <dbReference type="GeneID" id="27327931"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00848"/>
    <dbReference type="HOGENOM" id="CLU_152072_0_0_1"/>
    <dbReference type="OrthoDB" id="2391627at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11533" checksum="EC04995BF7455C76" modified="2015-04-29" version="1">MALSQEGFQSSGRTPLRVYNKQPTYNTYISPYGPKTKHVPNLMGLSLGKAFRYGTIASGFGVAAGTFALFFFGEVPKIRNDILSKVPVIGDYWVREIPPEDNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNF2</accession>
    <name>A0A0D2BNF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_00630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240271.1">
        <property type="nucleotide sequence ID" value="XM_016374995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNF2"/>
    <dbReference type="STRING" id="91928.A0A0D2BNF2"/>
    <dbReference type="GeneID" id="27327713"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00630"/>
    <dbReference type="HOGENOM" id="CLU_027694_3_1_1"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW20055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="518" mass="57581" checksum="BE9DC85A5E23ABEF" modified="2015-04-29" version="1">MFAVPGWDVSPASLVQQKQARKPEQVQSTRSDPLVNKKRKRNVLHDEPTSKISGADLERLWGLRKDAKLAQKPDTAKPQPRAQSHPKSITSKPDANQAVTENVRDKAPFKNGTKEKGTKKNKGGGSKHEDSLPHKEIHVQSGPPSVEQRGRNDVAKTHEQDDDLPQSSSAKNLNGSLPTRPPTANLTPLQLKMRSKLTSARFRHLNETLYTTSSTDAMSLFTNSPDLFAEYHAGFSQQVKDSWPQNPVDKYVVTIRTRGPLDSPKGDLLPLPRRKTNSCTIADLGCGDAPLARGCHTLVRKLHLKFHNYDLHAANPFVTKADISSLPLRDGEADIAIFCLSLMGTNWLSFVEEAWRILRGDGKGEVWVAEVKSRFGRVTRGPGRVVENSVGKRRKQQKPKKNADEDGDGIGHDVFVEEADGNADDETDISAFVKVFSRRGFVLREGSVDKSNKMFVSMVFVKSGVPTAGKHKGLKWNGHEYQRLQNGKMKFVPNPNEDEDISPEEEAKVLKPCVYKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPG7</accession>
    <name>A0A0D2BPG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01416</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241054.1">
        <property type="nucleotide sequence ID" value="XM_016375778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPG7"/>
    <dbReference type="STRING" id="91928.A0A0D2BPG7"/>
    <dbReference type="GeneID" id="27328499"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01416"/>
    <dbReference type="HOGENOM" id="CLU_008220_0_0_1"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="823"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="48"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="470"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="855" mass="95825" checksum="3091AEE97449D713" modified="2015-04-29" version="1">MPQPPFAPAVGSPSSNGFTFDDSPVQSSTASTSGKSSHSTKSAFLEEIKHEIMVSHLYQQQCSHLWVSDGCGDSEGVLLRRSRGQYLACPQALLDSHFAEACRLLNVAMTVNSRVIKTFFAWTPDATDVPLMNGLRIQILQTIHDLPRARKYQFAAYVASESLLVVWDDDPSNLLKRATTIESQLMELVWGIGEANEDEAVIHEKHGSAQVSLDSESREPIPECRATNLMNTILVAFTLIIVVVLLGLACRSLAIEIAVDHSYLRLAFLSLVPVQVFFTLFFAQVIVGCVAQCIGPVRQMQLNSKYFSARRSPRLRTESLPHITVQCPVYKEGLLSVIVPTVKSIKQAISTYELQGGTANMLINDDGLQLISEDERKARMEFYQDHNIGWTARPKHGSEGFVRKGKFKKASNMNYGLMLSCKVEEKLLEYHRPSTWTSNDENHAYDESLAQVIAETPRAWADGNIRVGDYILLIDSDTRVPADCLLDAVSEMEQSPNVGIMQFASGVMQVVHTFFENGITFFTNLIYTAIEYTVANGDVAPFVGHNAILRWSAIQQVSYTDEDGYEKFWSESHVSEDFDMSLRLQCDGYIIRLASWAHGGFKEGVSLTVYDELARWEKYAYGCNELLFHPIRQWIYRGPFTGLFRRFLLSNIRFTSKITIISYIGTYYAIGAAWIMTLANYFAIGWFNGYLDKYYIDSWKVWFSIVIVFNGLGNIALAIMRYRIGQASFLGALAENFKWILMLSVFLGGLSLHVSQALLAHMFEVDMTWGATSKEAEFSNFFIEVPKVVSKFKFSIAFAIVAIIGMVWLACNPGGLLPYDWVIGDLIAILPMSTVAASHLLLPIVLNPALMTFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPK3</accession>
    <name>A0A0D2BPK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_01457</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241094.1">
        <property type="nucleotide sequence ID" value="XM_016375818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPK3"/>
    <dbReference type="STRING" id="91928.A0A0D2BPK3"/>
    <dbReference type="GeneID" id="27328540"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01457"/>
    <dbReference type="HOGENOM" id="CLU_010353_2_0_1"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000046">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000008">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="15">
        <location>
            <begin position="22"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="16">
        <location>
            <begin position="653"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="17">
        <location>
            <begin position="806"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="618"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW20878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="921" mass="100752" checksum="C4518A355C9C6B34" modified="2015-04-29" version="1">MSYAKKDEDADHSVGFRLDRTSVFQDARLFNSSPISPRKCRTLLTKIGVLLFTGEKFPTNEATTLFFGISKLFQNKDPSLRQMVYLILKELAHTAEDVIMSTSIIMKDMTVGSEIIYKANSIRALCRIIDATTVQGIERLIKTAIVDKSPAVSSAALVSSYHLLPIARDVVRRWQSETQEAASSSKSGGGFLSFGGSSQHSLAAANTNYMNQYHAIGLLYQMRSHDRMALVKMVQQYGAAGAVKSPAGVMMLVRLAARLAEEDPSLRKPMMQMLDTWLRHKSEMVNFEAAKAICNLPGVTDAEAAQAIHVLQSFLTSPRAVTKFAAIRILHSFASFKPQAVHSANPDIEALISNSNRSIATFAITTLLKTGNEASVDRLMKQIQGFMSEITDEFKITIVEAIRTLCMKFPSKQAGMLTFLSTILRDEGGYEFKRAVVESMFDLIKFVPGSKEETLSHLCEFIEDCEFTKLAVRILHLIGVEGPKTPQPTKYIRYIYNRVVLENALVRAAAVTALAKFGVGQKDPEVKKSVKVLLTRCLDDTDDEVRDRAALNLRLMEEEDEIAERFVKNDSTFSLPTFEHKLVMYVTSDDKSVFSKAFDISQVPVVSQEQALAEERTKKLTTATPTLKAPSTGPAKPKANGLSDGPSAAAAAQKYTQEFSRIPELAAYGPVLKSSSVVALTESETEYVVSAIKHIFKEHVVIQYDIKNTLDQTVIENVSVLATPSEDEEATLEEEFIIPANALKTNEPGVVYVAFKKVEGEASFPVSTFGNVLKFTSKEIDPTTGEAEEGGYEDEYEVENLELTGADFVSPAFAGSFDHIWEGTGANGEESNDTLQLASVKSLADATEQLTQTLSLQPLEGTDVVLSNATHTLKLYGKSVTGGRVAALVKMVFSAKSGVTVKVSVRTDEAGLSGAIISVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQK4</accession>
    <name>A0A0D2BQK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_01338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240976.1">
        <property type="nucleotide sequence ID" value="XM_016375700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQK4"/>
    <dbReference type="STRING" id="91928.A0A0D2BQK4"/>
    <dbReference type="GeneID" id="27328421"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01338"/>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_1"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="313"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW20760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="422" mass="46008" checksum="87E7F29B4B001877" modified="2015-04-29" version="1">MPIRQPRLAIVGGGPAGLTVGILLHKHQIPFTIFEYRPKPTDDELESPVGMLDLHEESGLAALKECALLEGFESHTAVCSEAQIIANKEGDIIYKDDGGPEARPEISRNSLTKLLLDQLPAGSIHWEHKLSSASYLAGDSDNVEIELNFGRHGKHTFDFVVGADGTWSRVRTLLTSAKPRYAGLQYMMLAIRHVSERYPTISEYVGTGSFVSLGKRNGIMCQRALQDSALIYAFLSVDNEHFAEDSGLTKGTPAEASERLLNDEGLFGQFGPKLKELLQTACEEETRLDPNAKLVVRSLYTLPHGHSWEHRTGVTLVGDASHVMLPFAGEGVNVAMWDALDVSRSIIKAYESSATSAVAFQAALDPLVKEFEVNMAARAKEKADEASNNAKLMLGSEDGATAMADWMRAAMQQAKATRPSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQV4</accession>
    <name>A0A0D2BQV4_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241604.1">
        <property type="nucleotide sequence ID" value="XM_016376328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQV4"/>
    <dbReference type="GeneID" id="27329051"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01968"/>
    <dbReference type="HOGENOM" id="CLU_2306165_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="100" mass="11033" checksum="0ACA30DA6EE19877" modified="2015-04-29" version="1">MAAAARQKGAELAQLIAAVNKAHSERERLQREADLLLEKQKQMLVREAESLDALDHVDPPEKASATVFIGMDDKQLEEIFELSPGALLNFEGPIPIDRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR66</accession>
    <name>A0A0D2BR66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233950.1">
        <property type="nucleotide sequence ID" value="XM_016383247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR66"/>
    <dbReference type="STRING" id="91928.A0A0D2BR66"/>
    <dbReference type="GeneID" id="27336008"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08925"/>
    <dbReference type="HOGENOM" id="CLU_067202_1_1_1"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="326" mass="36062" checksum="B7893F4AE4767ED9" modified="2015-04-29" version="1">MEAHVQRLVDKTWEKFSDCDLSQRLLIAVAGIPGSGKTTLAASVARGLNKAYRQSRHAQFPNSPESDTSWPDIAIVVPLDGFHLTRRQLSAMPNAEEAIFRRGAAFTFDADGYLDLVARVRRPITPETPTVYAPSFDHAVKDPVADDVAIPPTARIVLFEGLYTALDADAWRDAHRLMDDVWFVDADIETATQRVAARNFAAGITDTFEKSLERTEASDMRNAREILEKRLPANEVVPSVEDEAWARSKELVRVDGQLQGVDVVVDDDDDQLRGQVQNNNNNNSGHGDGNHEADADDDESVSEEFRQQRMMRMDSIAALAADGVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSA0</accession>
    <name>A0A0D2BSA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_01890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241526.1">
        <property type="nucleotide sequence ID" value="XM_016376250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSA0"/>
    <dbReference type="STRING" id="91928.A0A0D2BSA0"/>
    <dbReference type="GeneID" id="27328973"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01890"/>
    <dbReference type="HOGENOM" id="CLU_017046_1_1_1"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="315"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="458" mass="50590" checksum="BC30EB78BEDF0B9C" modified="2015-04-29" version="1">METTSHRPWETNPPHSLPQTTQTLPSIASLTSKLPVQSIERPSPDLSILPHQRDSGSWMTPGTRSSVNSANSMPYLNSAHSPTGPSPYTPETTTAPSAPFNSTLPHQTNGLPTPSSDLNQHRGSGDYDESRRGSVTNSIHHGMNNLGLGPTSPYTSTNASQTSLVSGLQRERGIQQNGYNSSRYSTMNNPAAPYASSRGGRSGFVGGRVAPPILENPKQEVYSAEAPTRGQAYAFPDPEAAPRQQGRTPSTFSRRNSFAESFTSSILTVESSRLPLGQHELPEAHHHSLQHKQVDSLRGDPDSPNGNTPYSRTPELRITHKLAERKRRSEMKDCFEQLRARLPTSQNNKSSKWETLSRAIDYITQLENQNKQVRVDYETQRLKLAELEAKMHEMSQQLRGIQQPQSSFPPPPNVMPQSPLGYGSHFNSHDGSGEPNRTLPPIMTTNSMQGIQYSEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSB0</accession>
    <name>A0A0D2BSB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_06885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234320.1">
        <property type="nucleotide sequence ID" value="XM_016381218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSB0"/>
    <dbReference type="GeneID" id="27333968"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06885"/>
    <dbReference type="HOGENOM" id="CLU_950058_0_0_1"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="293" mass="32057" checksum="92182C758689CD55" modified="2015-04-29" version="1">MQHPPLPKHPSWTPPPVQLYTRQDYDGGDIVTSLSRNELGEYVFTIGLLSPDPSSHQTAHGHVYLPSRRRRRCGPLDRHDNAPGHGDHMDRAHRVQKYAPTAAKRGVVTGRPRLQPHVGRLRRHMVHAAGAQLSDPGIKDTARVDSTFYMATGGPEKLTPEMPGSNCVLERQMRAADWCDADANLLDLKLGSLEKYFASFLDATRAEELTGVLLGPPSKAEVPLVGAGDPRLGEDRRLYASLEPSTRTRSVAISHVCSDGLGNNLAGAIPLCEFERPPSWRDQFEGLGASGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BT76</accession>
    <name>A0A0D2BT76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241826.1">
        <property type="nucleotide sequence ID" value="XM_016376550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BT76"/>
    <dbReference type="STRING" id="91928.A0A0D2BT76"/>
    <dbReference type="GeneID" id="27329273"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02190"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF1">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="9">
        <location>
            <begin position="46"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="198"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW21610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="39992" checksum="48ADB4B60EB1D265" modified="2015-04-29" version="1">MGVMDIPETHKVSVLVREPTNTDTHAHTHNVQYHFETRVVSVPQIGPNDLLVRLSVSGVCGTDLGMASGHLGPCRDILGHEGVGRVVKLGSAVSPSFVDVGARVGIAWVRDICERCFCCLTPGGEARCMEMLCSGLRRDGTFAEYATVPSRYIIRIPEGVPDHLVAPVLCGGVTAFKAIKVSEATPGQWIVVSGAGGGVGALGIQYAKAMGYRVIAVDLGVSKREYCLELGAEAYFDAAVVQPADIQSLTGTNNGGAAAVLVMANSAKAYEAALGFVGPYGALVCVGIPPPDQTMRIHPLATIGKNVRIIGSAVGTRKDIWDAIEFVARGAVKPRVQMASLDDLSDIVKNFQKTPAKYVMRYIDEEEISANGVQSNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BTN6</accession>
    <name>A0A0D2BTN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Alpha-galactosidase</fullName>
            <ecNumber evidence="5 8">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_07378</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 36 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5 8"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234810.1">
        <property type="nucleotide sequence ID" value="XM_016381708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BTN6"/>
    <dbReference type="STRING" id="91928.A0A0D2BTN6"/>
    <dbReference type="GeneID" id="27334461"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07378"/>
    <dbReference type="HOGENOM" id="CLU_009640_2_1_1"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000118">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="entry name" value="alpha-galactosidase from lactobacil brevis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 36 N-terminal" evidence="12">
        <location>
            <begin position="43"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 36 C-terminal" evidence="11">
        <location>
            <begin position="653"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="367"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="487"/>
            <end position="491"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW14594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="730" mass="81014" checksum="36DC2C9ECCD2863E" modified="2015-04-29" version="1">MGSIAYPQPGDSLLRPIVVDGKSFALNGKNISYRFHVDETTGDLLSDHFGGLVTENPIIPGTTPSSGWSMNGSFRREFPESGKGDFRNPAVYIKHHEGFTVSHFRFQSYKVFDGKPDFPEMPATFGNVDEVKTLVVSMYDAYSDVAADLVYSVFAEHDAIVRRVVLTNKSAKPVTIEKVASFSVDIPAAEYDMVCLRGEWSRERAELRRKVEYGMQSFGSTTGYSSHHYNPFLGITSSKTTESSGDAWGYSLVYTGSFAAEVEKSPHGLVRTSIGMNQYQLSWDLQPGKTLVSPECVAVYSSSGIGGMSRNFHRLYRQHLIKSVFVSEPRPPLLNSWECLYYGVNERTIEKLAVTAAGLGVKLFVLDDGWFGDKYPRINDKAGLGDWKANPDKFPNGLNRVVDKVTKLSVAGSSKRLQFGIWVEPEMVNPKSELYAEHPNWVMSAGLHDRSETRNQLVLNLALPEVQDFIISSMTTLLQGNAITYVKWDHNRAIHENSAPQNYHAYILGLYKVFDTLTTRFPDILWEGCASGGGRFDPGVLQYFPQVWASDNMDGIDRISIHFGTSIVYPLSSVGAHVGASPSHVTKRTQSLKFRAHVAMMSGSFGLELDPETLDEAEKKMIPDLISLAERVNPIIITGDLWRLRLPGEGNHPAAMVVSRDGSQAVLFAYQLLSTVMHEIPVLKLQGLEAMERYKIDNGAIYSGATLMNGGIQIAFEGDCDSRVMCLERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BUB2</accession>
    <name>A0A0D2BUB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235080.1">
        <property type="nucleotide sequence ID" value="XM_016381978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BUB2"/>
    <dbReference type="GeneID" id="27334732"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07649"/>
    <dbReference type="HOGENOM" id="CLU_127198_0_0_1"/>
    <dbReference type="OrthoDB" id="3517343at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="149" mass="16713" checksum="40A6428D16BA3574" modified="2015-04-29" version="1">MAAQTIHIVGSKSIERQASPAFYSQNEFTISDPTLALAISSTSHHLGPPWCKLFRRLAADGVGLRQIYVYWDSETTFGHFGGGADVEVVRALAEIRGLQKLEIDGFFAKEWPAYLQGKTGLTVWSPHGKKAWYYQELRKFQRNTPDLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVR5</accession>
    <name>A0A0D2BVR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235600.1">
        <property type="nucleotide sequence ID" value="XM_016379773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVR5"/>
    <dbReference type="STRING" id="91928.A0A0D2BVR5"/>
    <dbReference type="GeneID" id="27332513"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05430"/>
    <dbReference type="HOGENOM" id="CLU_026673_7_0_1"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF11">
        <property type="entry name" value="ZINC-CONTAINING ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="34215" checksum="428728BF69B0BDC3" modified="2015-04-29" version="1">MHVAQVEKWGEPPKYTTVATPDPPDPASDDVQIKVTATAIHNLVRLRASGTHYSAKTLPHVPGVDGVGTTTAEGGEEAYFFDYHGSSGTFADLVTVPKANVFPLPAGADPIQVAALVNPAMSSWLALRKRAFHLPPGFSVLILGATSTSGRLAIPIARALGAGKIVGCARSRDALDSLRGVPAGGGGGGGLDSTLVLRDPVTATDFASLGHVDVVLDYVYGPPAEHLLHSVKALDRPTQYINIGGLAGATITLHSRVVRSSKIVMLGSGIGSWTDDEIRDELPGLLRAIVSSLPVPTIEVRSLRDVETVWGQNEKGKGGLERIVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BY16</accession>
    <name>A0A0D2BY16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236415.1">
        <property type="nucleotide sequence ID" value="XM_016380588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BY16"/>
    <dbReference type="GeneID" id="27333333"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06250"/>
    <dbReference type="HOGENOM" id="CLU_129450_0_0_1"/>
    <dbReference type="OrthoDB" id="5403157at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="188" mass="20367" checksum="002CC9F2AA6CFC58" modified="2015-04-29" version="1">MNPEPFSGRYTPTSPLSPRLAANHRPMSPNPVRSRTVQHNRQGSRNMHMSLPRFHPANFTNLDSPATPSSAVQSPAITINRVAPTMQLESPRLMREKQREFLERAHLSAKIAASSMGVKPGAPRLDPLGSPKGPVTPLALDEGGDYFQVAGAGKVSPAGSPGARSPRSDISDKEDSKKSNKRHSDVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0G8</accession>
    <name>A0A0D2C0G8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237340.1">
        <property type="nucleotide sequence ID" value="XM_016378663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0G8"/>
    <dbReference type="STRING" id="91928.A0A0D2C0G8"/>
    <dbReference type="GeneID" id="27331398"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04315"/>
    <dbReference type="HOGENOM" id="CLU_014021_0_0_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="474"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="507"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="541"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="632"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="725"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="882"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="944" mass="103173" checksum="12E426CAB7DEC8B1" modified="2015-04-29" version="1">MAPKKGKETLLELCTMATNVGNSISVRMLEYLGTVKHQPHGFKELACDFLDVSRILWSIEAGLNEAGRSQTKFPQDMTQELDKKFRQTNDDFIVLNQMLTKFLEYERKGRLGRFQRGLHSMFSDDEIHKLRESLGRSRDALRMSALVFRWSLGDAKADASVGIGYTGLAAVLERMNPGKVPSINTSTLPAEPPIHTPTPQTPPPSQVPDRLPPLPQISTVSDRHANYSLFPRLDEDINALVSHHIEPRTSSLDHRNGDAHSIHNSIHRHGDDHSIHRNGDARSIKALPSIRSSKYTTASTMRDLGPHSSVETAPTDVTLDDRLSVKTADSFTQIEDMISEIEFNDKQSQKVVRIKADPSTVPRWTPKQNSGSSSPALKTALISAIQQRKHKMIEQLLDCGVPPNSGMDLNVLREAVLNRDAESVRLLLLFGADPNSVDKSASTALMAAIETSFIEGTKLLLKYAADPNLPAGPRNETPLAVAVAETKVELVQLLLTYGANANMSTSDGNTLLDMAVTKTSPRRLTELLLIYGSDANGKSNRGETPLFVAIQAGRLDLMQLLLDHGADPNLPGPKHPLWPATYFPKGLQLLLSRGATFKRCPGILELATSINNIESVTTLIRAGVDINAKKDGTYTPLCTAIRDNRTELVSLLLASGADPNEPAAEYPAFKCVTHHRTHLLPQLVAAGSDLHKPKGIIEKAVAHNNKDALMYLLEQGVSANDRTPEGYTALTTAIREAKADFVDILLAHDADPGIRGQDWPICMAVKQPAILKKLLPKVHNPRAVKGVMEMAVGANELESVKLLLAAGVSVEDKNGGVFSPLTTAIREGHKEIVKYLLDEAGADVNAPGEHLPIIKAIRRFRGDTEIIEMLLARGADINLMYRGWNAILQAVENGDATVLQTLVEHGGTVDLDAKDESGRTVVEIVEERGWDEAVTILLGSKEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C4N8</accession>
    <name>A0A0D2C4N8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238750.1">
        <property type="nucleotide sequence ID" value="XM_016377180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C4N8"/>
    <dbReference type="STRING" id="91928.A0A0D2C4N8"/>
    <dbReference type="GeneID" id="27329905"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02822"/>
    <dbReference type="HOGENOM" id="CLU_000288_138_11_1"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="535" mass="60465" checksum="E14E9F478264D0EF" modified="2015-04-29" version="1">MRLLHTTTLDLHEFQGAPPPYAILSHTWGEEEVLFQDIGTPTSETKKGYGKIVKFCAQAKGASLDYAWVDTCCIDKRSSAELSEAINSMFRWYSKAHVCYAFLEDVDLRHNSGMRGSRWFTRGWTLQELLAPLHVVFFDQNWMEIGSKVGLLDELNAITGVPQSALACPATIHQYCVAERMFWAHQRETTRVEDIAYCLLGIFDVNMPLLYGEGKKAFRRLQLQIVSESGDHSIFAWNSPERRIVQRANPCDMLAESPACFTLRSIVQGPHKNNTRFQSMPKPEDVTITVSNVGLSMRLAIATLPHPPIRISKLKSVSKSLIAVLNCRREDRHIGIHVLHSTAYAGAWSRCQGREIVFLGDAMVRNLQSDLVIMTLGEPKASLLPYHRAVLQPMLDRDRLVHFADFTIAMSSSTSESICDNHTSLPPMVVVATHGSALMFTKTQKTAFILVFGMDHGRIWCAGFSCAVPSSLLEFAQSIWIKYHVGRETLPWRYYQDRQTHESDELNHLHVTIKPELVPTEHAGLISQYYRVDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAA2</accession>
    <name>A0A0D2CAA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240700.1">
        <property type="nucleotide sequence ID" value="XM_016375424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CAA2"/>
    <dbReference type="STRING" id="91928.A0A0D2CAA2"/>
    <dbReference type="GeneID" id="27328142"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01059"/>
    <dbReference type="HOGENOM" id="CLU_083329_0_0_1"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046503">
        <property type="term" value="P:glycerolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="278" mass="30793" checksum="3CB738206CD1D620" modified="2015-04-29" version="1">MENTKNSLEVPGATLYYEVVGNGPLLLCISGGSGSADYWRPLVNQLKDNFTVAIYDRRGFSRSYLSATVDQDYEHRIETDADDASALIKYLSPAEQPVKILANSSGAVVSLVLLLRHPDLVDTLVCHEPPALKVLPDREDLTAKQLDIYQTYRRSGIPAALKKFAALYKVKDAEFPIFQASMDARRGPFVGQNSIYWFEREIPVYPLQDFDLQALAKYKKKLILAAGEDTDPSAPHYRANESLAKICAKELTIVPGGHTGFATHPVEWAEALIKIAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CD45</accession>
    <name>A0A0D2CD45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241650.1">
        <property type="nucleotide sequence ID" value="XM_016376374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CD45"/>
    <dbReference type="STRING" id="91928.A0A0D2CD45"/>
    <dbReference type="GeneID" id="27329097"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02014"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_2_1"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW21434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="386" mass="42969" checksum="CD8CFCA087683696" modified="2015-04-29" version="1">MATQQSQSLLSRYRLLSPSAAVFVSPICLGSMNFGTAYKAMMGECTKETAFEILDHYFGEGGNFIDTANSYHAGQSETWLGEWMAARGNRDQMVIATKYTGILRSADQGIQIRANYGGNGMKSLRLSVEESLKCLQTSYIDLLYVHWWNFTASIPEVMQALNDLVASGKVLYLGISDSPAWLVTKANQYARDHGLRQFVVYQGAWNAALRDFERDIVPMCREEGMGICPYGVLNSGRFQTEAAYKEREKHNPGRHQATTSSRDKAVAGVLEKLANAKKATLSNVALAYILYKAPYVFPIVGGRKLEHIKDNIRSLSTSLTTDEIDHIEKAYDFDPGFPHTFLSGTLIDGADAPQRGASHPSEVPWTRYQGTFDWVEYPKAIPLRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CDD8</accession>
    <name>A0A0D2CDD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_02099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241735.1">
        <property type="nucleotide sequence ID" value="XM_016376459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CDD8"/>
    <dbReference type="STRING" id="91928.A0A0D2CDD8"/>
    <dbReference type="GeneID" id="27329182"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02099"/>
    <dbReference type="HOGENOM" id="CLU_108113_3_0_1"/>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050977">
        <property type="entry name" value="Fungal_Meroterpenoid_Isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598:SF1">
        <property type="entry name" value="AUSTINOID BIOSYNTHESIS CLUSTERS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598">
        <property type="entry name" value="AUSTINOL SYNTHESIS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW21519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16612" checksum="CDB982601C9CD48B" modified="2015-04-29" version="1">MSPLRDQLLKTAQGYLDGLNDPGPDAAGVIALRTPDCTQRILPQNLEQPLHTNQTYQEFMATGAKLMVSMPKFAFNSEPVVDEYARKVVLHMRGKGESPSGPYNNEYFIILSTTEDGTQIKEVVEFLDSQAFTSLVETFRKLAQESAAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CDQ7</accession>
    <name>A0A0D2CDQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241900.1">
        <property type="nucleotide sequence ID" value="XM_016376624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CDQ7"/>
    <dbReference type="STRING" id="91928.A0A0D2CDQ7"/>
    <dbReference type="GeneID" id="27329347"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02264"/>
    <dbReference type="HOGENOM" id="CLU_009665_2_2_1"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF4">
        <property type="entry name" value="BLR0106 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="407" mass="44747" checksum="2CE9F5B192C83B17" modified="2015-04-29" version="1">MQRGNIGSVIIAGAGPVGLLTALFLGQRGIPVDVVEAATEVNDAPRGLAYGPAAVSVLARAGILENVIERGFIPADVSWRKPSGEWLVGLERLNNMVDGLPNTVILPVGALSTLLVEEVQKYSSVTIHWGHRVLVASQTEEKAWVEVEEQKSKATRRMEADFVIGCDGASSAVRKSISGSNFPGWTWPNQLVAVNARMNFDKLNFSDVQWVVDPENWFVIAKIDKGGLWRIVYGEPAGLSVEEIKSRLPDRLRTTFPGNPEPSEYQVTNVTPYVCHQRCAEKMRDNRILLAGDAAHLNNPMGGLGLTTGVCDVGSLVDCLYGIDSGEATLDILNKYDEIRRQIFDRVVDTMSTANFKRIMQGAAEFQESDLSYKMIMAARTDISITTAMRKHDMSIGCDMTQFYNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y3X9</accession>
    <name>A0A0D1Y3X9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_12108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847517">
        <property type="protein sequence ID" value="KIW09641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229857.1">
        <property type="nucleotide sequence ID" value="XM_016386415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y3X9"/>
    <dbReference type="STRING" id="91928.A0A0D1Y3X9"/>
    <dbReference type="GeneID" id="27339191"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12108"/>
    <dbReference type="HOGENOM" id="CLU_1008431_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW09641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="276" mass="31526" checksum="43C6F497E9BB3474" modified="2015-04-29" version="1">MEKRERALPRLPVEIWVRIFKHIQSSFITERDHKVTFASSRRCQKWLFADAILTSCILNNCLWTMPGEVTLYIPACQLNRLPAAPPKESGLSMVVLYSGAAKGNEWGLEMISKPVTQWLKRLGPGRLEVRFVSPDVHRVEPTMIESLIGLNCRTRVDFGTPDDLFLSRKFATHTEHDHICLGGAIKRARDLAKKLGTAVERQKGSGVKHDSKLKLHGFRRMRCICEKQRGIPLDTLVNTILPPLLDHCVDKGGVYMPVDFDWPESYAHWRPVTTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y821</accession>
    <name>A0A0D1Y821_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_10390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231307.1">
        <property type="nucleotide sequence ID" value="XM_016384705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y821"/>
    <dbReference type="STRING" id="91928.A0A0D1Y821"/>
    <dbReference type="GeneID" id="27337473"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10390"/>
    <dbReference type="HOGENOM" id="CLU_098340_0_0_1"/>
    <dbReference type="OrthoDB" id="3907216at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW11091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="243" mass="27233" checksum="90E0FE94AA9C03C6" modified="2015-04-29" version="1">MSRERPLRGACNCGRIHYSVIVPGDSTQRAEVFFDNTSDSRRSQATPLTAWLRVPLTWYSSTTQAFFPDETHATIRRTFSPLHSPHTQRVFCGYCGTHLSYWTENPSSEADFMNITLGSLLGEDMHALQELDLLPEDVEPENIQGPSQTAVQAPTEQKQNQDVTWTERSGRSGGLSWFEELLDGSRLGRTHNFRKGVGVSSDGNTRVEWEIEEFFDDGSATPQTPTGSKRKLGDVTSDDLMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y873</accession>
    <name>A0A0D1Y873_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231397.1">
        <property type="nucleotide sequence ID" value="XM_016384795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y873"/>
    <dbReference type="STRING" id="91928.A0A0D1Y873"/>
    <dbReference type="GeneID" id="27337564"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10481"/>
    <dbReference type="HOGENOM" id="CLU_494310_0_0_1"/>
    <dbReference type="OrthoDB" id="5385013at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055795">
        <property type="entry name" value="DUF7371"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24086">
        <property type="entry name" value="DUF7371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7371" evidence="2">
        <location>
            <begin position="346"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="548" mass="58278" checksum="B87A4FEDF999D0CB" modified="2015-04-29" version="1">MAGFAAAGVLPAREVAACSTATVYGTVFATVYVHDVVTITHTITNPPPTVTIVEQDPGSKLSFIASYDTESVIEQSQLLPVSAHPDPKPTVVTEMVQVPGFEATEISYRGKTGTVFYIHGTGGSVEPTSPIIVEVTTFTILPTFATRPPSVANQAKAAATSNSTLHMAFTSSSNGWNYTNSNSSMWPAASGHGGAVPTEEATSTVTVTNTVATVTRVVASTAVASYGHGPEPYGYPPPDTAHPVEKRQTCLWVSATIGGQEVGWCNNWDGAATFSYTSWETTIFPTYVPGVGPVDTSTSSSPPTTSLPSSVRPSTTHGSSSSKPASVTVSPVPTTAVPAPATCGQTGPFIISFDDLPVLSVFNNNTAGFPEIFNPYEHFFWGDGWTYVPPPTEPFSPHDGTRLAQFIPSLANKDIGSPSAGLIPPSSFGAGPRAADSAYWFSAATAWVACDTANVTCDFVATAYQWDIATQSEVVVATQHFNVPPCHGFVDCRLTEIRFNYLFYKMTTLSFYANVEGKISIFWLDSLSLDWYDNSCEAGLKRISSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8S7</accession>
    <name>A0A0D1Y8S7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231607.1">
        <property type="nucleotide sequence ID" value="XM_016385005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y8S7"/>
    <dbReference type="STRING" id="91928.A0A0D1Y8S7"/>
    <dbReference type="GeneID" id="27337774"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10691"/>
    <dbReference type="HOGENOM" id="CLU_136313_0_0_1"/>
    <dbReference type="OrthoDB" id="5555533at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="112" mass="12714" checksum="2CAD674E239A3041" modified="2015-04-29" version="1">MSSDITDSFVDPTANIDESDLDDLPSEPDSDEVTVSDEDYESDAEREWNESLQQLEMLLTMVLVPYAGKYFGRKFAYWGWKRFMEWRYPVEIVVTNKAAFKGTGAIVAAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y9A0</accession>
    <name>A0A0D1Y9A0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_10837</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231752.1">
        <property type="nucleotide sequence ID" value="XM_016385150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y9A0"/>
    <dbReference type="STRING" id="91928.A0A0D1Y9A0"/>
    <dbReference type="GeneID" id="27337920"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10837"/>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_1"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="714"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW11536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="759" mass="83204" checksum="D5F230C640BD2437" modified="2015-04-29" version="1">MSELPCVEMTNWEKGHYINYKKMSENLSVVRSRLNRPLTYAEKILYSHLDDPHNQDIERGVSYLKLRPDRVACQDATAQMAILQFMSAGMPSVATPSTVHCDHLIEAQVGGDKDLDRAKSINKEVYDFLSTACAKYNIGFWRPGSGIIHQIILENYAFPGGLMIGTDSHTPNAGGLGMAAIGVGGADAVDVMANLPWELKAPKVIGIKLLGELSGWTSPKDIILKVAGILTVKGGTGVLLTFYHSTGPGVDSLSCTGMGTICNMGAEIGATTSLFPFNDRMYDYLAATRRQHIGDFSRSYAAELREDEGAEYDQLIEINLSELEPHINGPFTPDLATPISKFKEAVKENNWPQELKVGLIGSCTNSSYEDMARAASIAQDAMDHGVKAKALFCVTPGSEQIRATIERDGQLKTFEDFGGVVLANACGPCIGQWDRKDVKKGEPNSIISSYNRNFTGRNDANPATHSFVTSPDLTVAMTIAGDLGFNPLTDTLKDKDGNEFKLKPPSGDALPRNGYDLGRDTYQAPPEERSQVEVKVSPTSDRLQVLQPFEPWDGKDFKDLPILIKTKGKTTTDHISMAGPWLKYRGHLDNISNNMLIGAINAANGEANKVKNFKTGEWDAVPATARQYKKDGIKWVVVGDWNYGEGSSREHAALEPRHLGGIAIITRSFARIHETNLKKQGMLPLTFSHPEDYDKINPDDKVDLLVTGLAVGKPLIMKVHTKDGKTWDCELSHTFNEGQIEWFKNGSALNTMAKKHGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDH4</accession>
    <name>A0A0D1YDH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoyl(Octanoyl) transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233222.1">
        <property type="nucleotide sequence ID" value="XM_016382519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDH4"/>
    <dbReference type="STRING" id="91928.A0A0D1YDH4"/>
    <dbReference type="GeneID" id="27335276"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08193"/>
    <dbReference type="HOGENOM" id="CLU_035168_0_0_1"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="111"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="367" mass="39972" checksum="7088C1D4A017BED1" modified="2015-04-29" version="1">MRLAHLHIRRLIPYSHSLTLQNAILERHFTYKDAVRGLNDAPPPGENVACRATGDGGVSTSPSAKASSSPASMSAPLPRTASASRNAHAYKDSVPQSSNSVSIPSFSSTLPPPDPTLLTFSTDPTYTVGRRHLLANPISQSQQNFLTADGLATFHASPRGGLLTYHAPGQLTGYLIADLRRHGITARCWVKMLEDSVMRTCGHWDVQTMRTDDPGVWIRNERELDGQDPQADESPVDRKICAIGVQVSRGVTSHGVGLNVFDAAFPQFVKDGYGFTPEQIRSPSYDPRSEGYLSWGFSRIVACGLEGKSVTWFAREGPEDSPQPPALEDVADVLAREVMRGFNDMKGPQKEAVKGVYRIEESDILAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YF44</accession>
    <name>A0A0D1YF44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233917.1">
        <property type="nucleotide sequence ID" value="XM_016383214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YF44"/>
    <dbReference type="STRING" id="91928.A0A0D1YF44"/>
    <dbReference type="GeneID" id="27335975"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08892"/>
    <dbReference type="HOGENOM" id="CLU_711803_0_0_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="387" mass="46804" checksum="E9BEC20570970620" modified="2015-04-29" version="1">MPYYTDSEDDYVLMPVRSHAGSEYRGRRRTTRVVERVVEPEEVVINNHLVVPGGSRPRAASTGGGQAPMTINIAASDRGHSRSRSRHRHDSCSSGSDHYSARSRSRHRRRPESKVYEDDLAYSLRKELDLARERRDEDRQKRDREEERRRWQREEEDKIRQKEREKEAREEERKRWQREEEDKKRQREKEREAILLEAKLEEERKKKAAEELRQKILKDEEEKQRKEKEKKKAEEEEFERKVKEKFMNAGYSPEYIEEILHKKKQEKANKALAIDLQRPTYIKVNRKYLHPDTLDYYGLPWEWDSRDTEYIIIKKYIDNTFQDELFEHTRRLKERKLITGPYVKETKTITTLTPNDHSYVKKGDKMYVVREKSKSPSRSRRSSWMFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YL28</accession>
    <name>A0A0D1YL28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235972.1">
        <property type="nucleotide sequence ID" value="XM_016380145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YL28"/>
    <dbReference type="STRING" id="91928.A0A0D1YL28"/>
    <dbReference type="GeneID" id="27332889"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05806"/>
    <dbReference type="HOGENOM" id="CLU_028601_0_1_1"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="293" mass="31796" checksum="ED617BCAAFE184CD" modified="2015-04-29" version="1">MAPGQSRSVFVGNIPFNLSEEYIVKILNYAGTVVKFRLMTNPDTGKSKGFGFADFQDADSAANAVRNLNDFEIEGRKIRVDWPHNNEKDSVPANYDQTSAAVADGFQPSGPNALPPLPPGVDLPPNLRATDAISQTLSNLSPPQLLDVLTQMKALAISDPARATSLLKTAPQLSFAIFQALILMNLVDPKVLAQVVEQAARPPQPAAIPPPQPTPQQYPPPMVPGQVPARPPPPPQQYAPPPVQQQPPPQAQAQLSQQEMIQQILAMDQRTIDSFSPTERAQIMQIRAQMGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YL97</accession>
    <name>A0A0D1YL97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_05866</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236032.1">
        <property type="nucleotide sequence ID" value="XM_016380205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YL97"/>
    <dbReference type="STRING" id="91928.A0A0D1YL97"/>
    <dbReference type="GeneID" id="27332949"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05866"/>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_1"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="6PGD_dom2"/>
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        <property type="entry name" value="6PGDH_C"/>
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        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
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        <property type="entry name" value="6PGDH_NADP-bd"/>
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        <property type="entry name" value="6PGdom_BS"/>
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        <property type="entry name" value="Pgluconate_DH"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
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    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="205"/>
            <end position="501"/>
        </location>
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    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="36"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
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        <location>
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        <location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
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        <source>
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            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KIW15816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="514" mass="56229" checksum="0C0DF3790E89D85F" modified="2015-04-29" version="1">MCLPIDGNHADFSARLAGLQVGPAQSEPSGDFGLIGLAVMGQNLILNAADHGFTVVAFNRTVSKVDRFLDNEAKGKSIVGAHSIEEFCAKLKKPRRMMLLVMAGPAVDDFIEKLLPFIEPGDIIIDGGNSHYPDSNRRTKYLAEKGIRFVGTGVSGGEEGARYGPSLMPGGNEEAWPYIKDIFQSIAAKSDGEPCCDWVGDEGAGHYVKMVHNGIEYGDMQLICEAYDIMKRGLGMSYAEMGDVFAEWNKGVLDSFLIEITRDVLRFNDDDGKPLVEKILDAAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSSIKDERTRASTLLSGPTPKFTGDKAAFLKNLEQGLYASKIISYAQGFMLMQSAAKQYGWKLNKPSIALMWRGGCIIRSVFLKDITSAYRQNPDLENLLFNDFFNKAIHAAQPGWRDVIAFAVQAGIPMPAFSTALAFFDGYRTKDLPANLLQAQRDYFGAHTFQIKPEYANEKFKVGAYTHVNWTGRGGNVSASTYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YLD9</accession>
    <name>A0A0D1YLD9_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236067.1">
        <property type="nucleotide sequence ID" value="XM_016380240.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D1YLD9"/>
    <dbReference type="GeneID" id="27332984"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05901"/>
    <dbReference type="HOGENOM" id="CLU_924468_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="301" mass="34558" checksum="F3D0506CF43F847F" modified="2015-04-29" version="1">MSDQNDPTLSPPLRPFRTKDDLDEEDKDELEILIDRLTLSCDNLAKAKPAGTRRRFGRDDRKDLETDLENLFVLLNDWLSRPRASTTAKIQISEKAKKSSLQLFFLLETYEIVTGAGIVLGDDFVEKIFSAAVDFVAALELEEVLLDNGEMWKPASIERWEPSVHGHEQEHFSFSAPTPEEAAREREEARARIERLLQEQQRSLPRPVIMDRIDVHTDTVKKKITDISKEQVNKEAHYHGMLGKKWLETAQERLENLGRVEIAANEEPDETLAVDHDRAGTPDDDDLLRYPDADYVPRKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNA1</accession>
    <name>A0A0D1YNA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dihydropyrimidinase</fullName>
            <ecNumber evidence="6">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="6"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236742.1">
        <property type="nucleotide sequence ID" value="XM_016380915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNA1"/>
    <dbReference type="STRING" id="91928.A0A0D1YNA1"/>
    <dbReference type="GeneID" id="27333664"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06581"/>
    <dbReference type="HOGENOM" id="CLU_015572_2_0_1"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="50"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="499" mass="55027" checksum="655DD20A91038BEA" modified="2015-04-29" version="1">MQSFDVILRNAHVNGAYVCDIGIKHGLISSLGVNLVASENTQIIECEHAIVTPGGIDGHVHLAQDKSPRAREAGYQCADTIETGTRSAVAGGTTTVLLFAEQSRGESVLEKVDAYHQLATYQGSHADYGFHIIITDPTPKVLEQELPVLARQGISSMKLFLTYKHMRISDKDFLRALHKARELGMVALVHAENGDLVDFFTEQLESQGLTDPVYKAIAHPAAAEAEATNRAVTFSSVMDTPLLIVHVSVPESTEVIRKAQSHLKPVFAETCPQYLLLGKSQLAQEHFCGAKFICSPPLRSDPNDVEAIWRGIINGTFTIFSSDHCPYSFTGPHGKQLGLSRADNGNPNGMFTKTPNGLPGVETRVPLLFSEGVLRRRCIDIKRFVELTSENPAKLYGLYPKKGAIQVGSDADLVIWHKSFTPRRLQHDRDLHDGCDYSPYEGIEFLNWPKMTLLRGRVVFRDGQIVNSSKYGEFVPRKGCTLPLSRKMVGSWDVLYAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQL9</accession>
    <name>A0A0D1YQL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_04695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237717.1">
        <property type="nucleotide sequence ID" value="XM_016379040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YQL9"/>
    <dbReference type="STRING" id="91928.A0A0D1YQL9"/>
    <dbReference type="GeneID" id="27331778"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04695"/>
    <dbReference type="HOGENOM" id="CLU_020695_4_0_1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="99"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="194"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="197"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="414" mass="46820" checksum="80A7B228080A76DC" modified="2015-04-29" version="1">MAYNRISSFGSNDSGYESGIVEIFDEPSLPLNKKTDHAKDVARRRQQLLASELSRRDSDEYQNDMLEHMLKMDADTMPDVDAIDIQTEIQWFMRPYLLDFLVEAHSAFQLLPETLFLTINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYGDKKEKVPTIKELKSMCCSLYDDDMFLQMEWHVLSTLGWAIGHPTVDSFMRLAVKDNVYDPEAESLCLYILEIALYHREFVSKRSSTLSLSALALARHILGRPQARVNEFGSHFCSTTVMELLNKVHDPSSILTRKYASVRYNSVSRVLSNFLAQKATAMSASTRTPLTPNYELTPPSVNAKPAGTEYFQTYATPQKPQFPSVVQHGLYTPPITPEGDMFGVTQKTFGAPNQYAPPTPTPTAVIGQQYSSQYPSTTNHWSAESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRW6</accession>
    <name>A0A0D1YRW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238187.1">
        <property type="nucleotide sequence ID" value="XM_016379510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRW6"/>
    <dbReference type="STRING" id="91928.A0A0D1YRW6"/>
    <dbReference type="GeneID" id="27332249"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05166"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF45">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="257" mass="27222" checksum="2823BB1B0DEBD2BD" modified="2015-04-29" version="1">MSYTCLKGKTYIVTGAASGIGREISIRLAKQGANIGLVDLQMPDQVLAEVVRAGAKGFAVAANVCHSDEIETAFGQIAHHFGGLDGGVNFAGIIGKNYKLGQKETSLQNLQDDDWSSVINVNLGGVMNSIRAELKLMKGPGAIVNAASLAAQIPTPYNSPYGASKQGVISLTRAAAQEVGARRIRVNAVAPGFVKTPMLEQFSNDNDVIQKRVIEPRVALGRMADPEDVARAVLFLLSEEAAYITGHVSFYLPTPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSG1</accession>
    <name>A0A0D1YSG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_02479</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238407.1">
        <property type="nucleotide sequence ID" value="XM_016376837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YSG1"/>
    <dbReference type="STRING" id="91928.A0A0D1YSG1"/>
    <dbReference type="GeneID" id="27329562"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02479"/>
    <dbReference type="HOGENOM" id="CLU_037162_0_2_1"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="11">
        <location>
            <begin position="245"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW18191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="415" mass="46411" checksum="B5BAAB5D757FD834" modified="2015-04-29" version="1">MPPPPQPDLPHPAHLDRDSALGRKFGKEVTNYFGGSPLNRLSFLRDDYGFLAQAFAHPTTKFLVFKTLSPLIKSPTEIHYATYDEIKTLVPSNPFEKSEKETLEDFDSRIETPQLVFLGIDENVKDGLKFRHFCGAPHWAIDITPKPTYEKEANELNEKFLASGLKFSEGMRAMSFPADVAAQYAQGRHYLDWNFRNTFCGTCGQRTLSVHAGGKRVCPPKDKARDPPEREPCSTRTTLSNLTFPRTDPTIIVAVLSHDSKRLLLGRQKRWPPYWFSTLAGFIEPAESVEDAVRREVWEESGVILSRVLIHSTQPWPYPANLMIGAIGQVASPEDEEIKLEHDPELEMAKWFTLEEIQEALKNGTSGLGEDAPKDYKEGNLRLPPPTAIANQLITAVVAGGFLEGVTPLATANKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSS6</accession>
    <name>A0A0D1YSS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_02614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238542.1">
        <property type="nucleotide sequence ID" value="XM_016376972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YSS6"/>
    <dbReference type="STRING" id="91928.A0A0D1YSS6"/>
    <dbReference type="GeneID" id="27329697"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02614"/>
    <dbReference type="HOGENOM" id="CLU_007604_0_0_1"/>
    <dbReference type="OrthoDB" id="2110361at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="682"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="744"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="786" mass="89186" checksum="8DF74AF6A9585DE2" modified="2015-04-29" version="1">MQSHLYVVKDSPTGASSTSPVSVHDQSQQPGSVPSFPAHACPGLSPQEPSTMSSFYPSHELESASPHDSLSYLGESLRAGGVGSGTPSPAQISAVMMHNPKRAYRQRRKDPSCDACRERKVKCDATETSSCTECSSRNVRCQFTKDTNRRMSSMKQVQDLERQLNEARQQIDRQRAAEQRNDLAPQFRPDMASLVFSDFPTVGKSPRRMLKARSPQDLTNARVHLYDVGRGLLKPPVTGAQPRSHITPSNVSDLQGLPSRPVAERLLHYYHECVHRHFPVLYWPKFQRTFAIAMEQPNTQLLPIDWVATLYSVLACGALATHDVTRVQEAQNYLTRAIATINFWEDDVTINQAIVAFLASIALVEMNRKSASWIWLGSAIRTVQDLGLHVQGGQWSPIEGEMRKRIWYSFYVWDRILALELGKPMMINDDECDTEYPEVLDEERLVADDVETLLPATLLLAGVYVSRLMAPLAKMFRSLCITNEALTKFETHLGDCLQLLPQPLQLSTTTPLDPCIMAPILYFQNTRLLLHRHNLSPSSSPEQRAQAIEQCVHAARDTATILSRCMTPHIQSHEWEQRFILSSTTILCTHLLRCMLLLLLRQFFDPFYLMLRAASTINDARSINICCGRYLSFFVRRLIEYYERSGALDPEHDEEILVYLSADLQASTNSWVWGNAETGTHLSRRQKHGRPKNLNTENEQFPPRPVSSPSWDSFLSEEEQRDWGGWQHIENSAKYFQRLCETRQQRMHDQDPSPHPHPRTLPPLPLNTPDIPAGDNRSRMTIANII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YT65</accession>
    <name>A0A0D1YT65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238692.1">
        <property type="nucleotide sequence ID" value="XM_016377122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YT65"/>
    <dbReference type="GeneID" id="27329847"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02764"/>
    <dbReference type="HOGENOM" id="CLU_669081_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="469" mass="51647" checksum="5634A07A9766DA47" modified="2015-04-29" version="1">MSSVVLLCAKLVYRVTTSGLSKHQSLDAHLPRASDDSTTTISRDCDAQLEVPGSFPHSISIVESKQLSTSRISENNTEDQISRSGPTTSPLDGLLILIQTLGASVSQPLNIVIDSRIASRCFRSTLTHDHFGHGFQAGGWRWQCSQHHAPPGRQHHPLLPLFSATAGRYISGRHEPLSSGHSTTEVLNQDMILPGTEYTASGLCQDEYQQVQLEYSASGRRRDRGNIQPGNGSEQQNHQQRQDGRTNSTSGANSNNADGPSRSRSAAVTGGGSGSSGGNDDDDEGRDRDGHDPSNPTTSPSYASDSDPDSDPDADTDTDTDTDSDSDSDSHTEGGARLVPHEAFGSGPSIPRRNDSRSALIHPSTPDPGYMIQDEEDDADVDTDTDGSEFRYSDSDSESEGASDDEDNSQRQDHDRHLDYDYDYDYDYDRDRDRDRDRQRSTRPYPHRYRYQDRLGRRMAWDWTGNPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVV9</accession>
    <name>A0A0D1YVV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239627.1">
        <property type="nucleotide sequence ID" value="XM_016378057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVV9"/>
    <dbReference type="STRING" id="91928.A0A0D1YVV9"/>
    <dbReference type="GeneID" id="27330789"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03706"/>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="256" mass="28108" checksum="B11CFF29CE45C6DE" modified="2015-04-29" version="1">MTSHSPQACCFSGFRHEGTPKGHFETIANVRAYIASPKDQKPTHAVLLLSDVFGIYVNSQLLADDFAASGYLVVLPDLLDGDAMDIGAFEAGQIDIPAWLSKHGSDTVDPIIDRIINHIRTYLSISKIGGAGYCFGGKGRELSAFYVIRFLKASKLDAGYTAHPSFVTDEELERIGKPLSISAAEIDSIFTTELRHRSERILAETSQRWQINLFSGVTHGFAIRADLKVPQNKFAKEQAFLQSLGWFSSTLGQPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYZ1</accession>
    <name>A0A0D1YYZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240707.1">
        <property type="nucleotide sequence ID" value="XM_016375431.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1YYZ1"/>
    <dbReference type="GeneID" id="27328149"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01066"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_1_1"/>
    <dbReference type="OrthoDB" id="5342314at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="326"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1072"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1321"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1324"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1348"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1388"/>
            <end position="1400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1400" mass="158653" checksum="153EBD7B4D207F02" modified="2015-04-29" version="1">MGSELERHGLFVLYPLKDNASWDVDIVVLHGLGGDPFTTWTADNKRMWPRDFIPEIIPTARIMTFGYNSKVAFSPSTADIKDFALDLLTRLRNKRWSAEEMNNPIFFICHSLGGIVCKQALLLAQSQPYYTNIFEKTSSILFFGCPHRGSRVASWGTVFANVINTTTFHKPVQKGLLTNLSFSSQILADISTAFKEIASDIDIKTFYETAIMLPLKVPVVERDSAILGLPTEQTIPIAANHREMVRFANINSEKFDPVKFALREVKEGRPLDVRAARDAFMYLAIELNVADYDQQLMKIPDQYPGTCEWLPKHASFCSWYDETDSDTLWLRGYAGAGKSVMTKYIIAKVLRALYIWSQKPPLTDSEHHKSHGDFLAYFFCSERNRHLQSERNILRSLLHQMLLAAPFEVNKALQAFRRPSAEYTFIARSATLWDAVKTAMIATSWQTIYLVFDGLDEMASENLGSFVKGLKHLIDSVAPRIKPRRIKLLLTSRPMSSLEALLDCPSISVRSERDVKFYVQGRTNELARRFALSHELQTDIVEKICQKAGGMFLWAVLAWHELCHEANKPDDFSQNLVKAQKLPASLEFLYEDIMNRLPISCRELALKILTWLALSARPLHSCELRFAIAMNHKRSYQQTVNNMISEHQLRTICPALIAVSDDGYVQFVHTSIKEFFLRSTTPATYRVDIVQSHANIAIQSLRMLHMPGFDAKTVLINLTSHKVHQREDMLDLPTLYYFLSYAATNWQYHAGLAGEDLSIWEAFKDFLNAPESVKLWLMLALYDGSIGAQRGWSEGKNFWQNLTIPPRIHIAVYLRNQFLVARLVQDGADINAVNRGWRNAAKEYRRPIMSVGGTILDNDLEPHLVDALVRMGANVNANAEDGLSAITRAINDRDEERVSMLLSAVREARTPSNSLGYVPSVLFEASSMTMRKVVSEILDDPRIDPCHDSVLQKDTSILGTWYATPLEHACLFGMESIAQLMMEHPRMIKAQQRIEKERPGRSPISLAFLCALQGWSELTLFALQNFQVDLSKERDVNRRSILIHAVMEEWHDVLEHCVNHLPRSKLNIQDKNGMTALHYAGKVRNWYAAKRLLEAGADSYMEDNEGRTPAHTAAEAGSDRVLRIMLDRGTVDTDGVDHNKRTVLHYVATWNLNAIAETLIDIAPDQVKVKDHHGRTPVHLAALFGSTAVLAQMLSTGLVDVNIQDNLGRTAFHLAVEGKVESCINELLSRQETDLNILDRNLKSPLDITLTYRHPQEAENVRNLLEAAGCRPGLWRPRRSYGNTLDEADPRDQELNESENYLALMRIVPYDPEIARANEKENVEGTSMRDSPAQETSKSPTHPPSSRTEPEEQARNSHLDTDERPATPPQATTETSRRPKRKFIRNLFKKDTIHGDGRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZ70</accession>
    <name>A0A0D1YZ70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_01141</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240782.1">
        <property type="nucleotide sequence ID" value="XM_016375506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZ70"/>
    <dbReference type="STRING" id="91928.A0A0D1YZ70"/>
    <dbReference type="GeneID" id="27328224"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01141"/>
    <dbReference type="HOGENOM" id="CLU_024853_3_0_1"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="84"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="153"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW20566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="268" mass="29550" checksum="B383A4A4E484289A" modified="2015-04-29" version="1">MALKTLGPKPAAELDKELMSEEGGFSIDQLMELAGLSVSQAGKYTHETPFLSPRHFSRQWTWLVYKVHPPSKGKNILIACGPGNNGGDGLVCARHLYHYGYTPTIYYPKPTNAPIFTGLQKQLRHLHIPFLATPEDFTATLKSTDLIIDALFGFSFHPPVRAPFDTILTAVIDSPTPVLSVDIPSSWDVAGGPPPEKDLVGHNFMPEYLVSLTAAKPCVKHYKGQRHFIGGRFLSQDVAKKYGLDVPDYKGVDQIAEVPVDIKVEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z9J5</accession>
    <name>A0A0D1Z9J5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_12107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847516">
        <property type="protein sequence ID" value="KIW09642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229858.1">
        <property type="nucleotide sequence ID" value="XM_016386414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z9J5"/>
    <dbReference type="STRING" id="91928.A0A0D1Z9J5"/>
    <dbReference type="GeneID" id="27339190"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12107"/>
    <dbReference type="HOGENOM" id="CLU_1266904_0_0_1"/>
    <dbReference type="OrthoDB" id="4161428at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="218" mass="24881" checksum="E07764EBC86CE9B1" modified="2015-04-29" version="1">MPINCLNLAAVKANPQPWFLANNMDYQVMRLVREGHSAGKDLVGHDADLTNSETFQLLAKAGAFSMPHVDRHGVMTVVHVEEGFKDWLIFPPLSEEEQAEFARGENYCPNYRPMNLRLRPGDTLILPPSRLHAVFSPTDVLMTGNMFWDSREVLRILKQSNLERLNPELSNEDPAQEFPVKMKAILDLWERQCGPWTWGSRQELEAARGVFQVSCYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z9Y5</accession>
    <name>A0A0D1Z9Y5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230048.1">
        <property type="nucleotide sequence ID" value="XM_016386240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z9Y5"/>
    <dbReference type="STRING" id="91928.A0A0D1Z9Y5"/>
    <dbReference type="GeneID" id="27339016"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11933"/>
    <dbReference type="HOGENOM" id="CLU_099515_0_0_1"/>
    <dbReference type="OrthoDB" id="4868994at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="135" mass="14675" checksum="485E1BA14C1197D4" modified="2015-04-29" version="1">MADPQKQEEAKQSFLQSAKKWGENPVPPALLATLVFAQHARPFQPLPMLFPPMLLFSTYLNLQGFKIDSAGTTAALSGSYLVLASRRRVGLFNKFGTRGIIRGVTMGLCLANLVGGGLAYGFGSRSKEDDKKRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZI72</accession>
    <name>A0A0D1ZI72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232783.1">
        <property type="nucleotide sequence ID" value="XM_016384160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZI72"/>
    <dbReference type="STRING" id="91928.A0A0D1ZI72"/>
    <dbReference type="GeneID" id="27336927"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09844"/>
    <dbReference type="HOGENOM" id="CLU_024585_0_0_1"/>
    <dbReference type="OrthoDB" id="5424692at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="504"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="568" mass="63251" checksum="2B3B0964685E9353" modified="2015-04-29" version="1">MTDMQRSPRRSPPPRDRPHRERDDHPNVEYFGEGESYRPGGQTGEGPYRPSPRDRIGADSWSADRRDGRRDERRDERREDIDSYIPTTSSRVSRPRSRSPPPFRRRSRSRSPPNRGREDLFPNRRSPPRRYSPRRSPPPRRRSRSPYGVRPRSPPDTKRYRDYSPEPSRRSPKRERRLSPERNRFDRRSPPRRGFSPDRDIVRGGESYRPRSRSPPRRRPGDDNWRRRSPSPRASGPASNNTSRRSSPPAPQLDRVSVAGSAARSPAYPAARNQNDRQEPSSYPERSADPPRTREASTTRDDVRSNGEAPQPPSGPSSHRNGEYSRPPPTGPSRSFSQSQHSPPTGPAASLRGAPRAVPTGPRGAVGRFDTPSRDFTSPPARGRGSLTYRGGPPPFGPRGGGYGRGDFGGSSSKGDYGASSGGGVVSSNSGRGDLAGGGASSYRGGGFGRGEAVPFRGNNSTSATYPRTQRFNTVQQHLSTNEKTVPGGKLLPSGLPPDQEKRIKMLEAEAERIRSEIAEKQKSKRDVLDEWEIRERESERESLRSELADAHLQQLMEGEDGLGRAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZSP1</accession>
    <name>A0A0D1ZSP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236058.1">
        <property type="nucleotide sequence ID" value="XM_016380231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZSP1"/>
    <dbReference type="GeneID" id="27332975"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05892"/>
    <dbReference type="HOGENOM" id="CLU_483145_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="564" mass="62685" checksum="72BFF2B81CF69A58" modified="2015-04-29" version="1">MTIPARRKLEAEIDRLRDEVRALKGQKASVEHKAGEIKNERDDLLREKQEWQARLLETATTSATATNEQKGEYQRSETGTQTDLVQVAEEDQSAATAMVAELQNWKQWFGELNQAYEKTKETLGRCDQARQAAAGERDAALAHAANLQNEATEVVRVLTQENDALKESISQAQVQANDQGSRNSAAAAAAAAAYKTAFENAEAKTKALEQELKHVKQKFEVYKTSEVTAIKRELAHFKNEHSRYLTMYDNAHKEVQQLEQKVGGLEGIEAKYEEARSKAKKYEKAVLGEEHYRTRHDEMVKKLGDVEAGKRWMEAQAKEQIHKLKDELRQVRARSVGGGGGDGVQEAEDRMQTTPPTPSPLPSPVPSWLRDARSPSPASTPGRMGSPSPGGAGGGRASADRDRAGMLKTIRGLATDKATLSKEVKGLKAANEDMEREIGRLRTANAGLVGKVDELETEVDVWKQTNDVDVERQKKAAAENEQRLCWKQAEVHAAESRAEVVASFHDALRAQQSQQGQEQLDESTSPRKKNKRVASEKLGGTVKKGLWQEEEEEEEEEEEVSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZV17</accession>
    <name>A0A0D1ZV17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236768.1">
        <property type="nucleotide sequence ID" value="XM_016378091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZV17"/>
    <dbReference type="STRING" id="91928.A0A0D1ZV17"/>
    <dbReference type="GeneID" id="27330823"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03740"/>
    <dbReference type="HOGENOM" id="CLU_011409_6_0_1"/>
    <dbReference type="OrthoDB" id="4116715at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="492" mass="56820" checksum="37F461990A251711" modified="2015-04-29" version="1">MAVTRRSRTGCITCKTRRIKCDEQKPSCRRCISSKLICEGYFVGPRSISAPSQLLNDEERRAFLFFQTRTVHRIFGQRDAKDWISILLQLSHAKPPVKHVIVALASVHESLEPVNDFILIRKRPGPAENIAYMAALKHYNIMIHFLRTEPLNTSSQPDTILVLCILAVCFEQFRGNDATCLLHLTAGIQLLSSWRTRTDNYNKLQNFSRPTADLINQQLAPILQRLRVQFALCMDLRHAWRNTGSPPYLPRPSIPSSYEDLDKARSDFDRLMNYTFTTMERCLEEGRTIPKDHLTATLIHWRQAMNPSRATGRSSSIQTCTYKLLMLYFHLSLIIIGTYGTSFETDFDEHGDAFELIANLAHELLQYWRTEPHQYSSLFSFDLGITPPMFFVASRCRNSKIRRKALGVMLLSPFYHGTWSDRYTGLCAQRIIEIEEESQQPSGDNMYIPEHQRIRKVSADLEKDNAQIVMQYIRAPFHQTSEVYNTFIPVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZV90</accession>
    <name>A0A0D1ZV90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236863.1">
        <property type="nucleotide sequence ID" value="XM_016378186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZV90"/>
    <dbReference type="GeneID" id="27330918"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03835"/>
    <dbReference type="HOGENOM" id="CLU_2145891_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="112" mass="11663" checksum="2DDF36BFBD34F70A" modified="2015-04-29" version="1">MSTTLPGWSGGGASAFEVGDGDGVGAEKGIASCLGTRGPSQPGSRSTNSDQCGNRFWLKTIGAVRAPGGITASTWRLLDLPQAAHNESVKDLPFERNRRFAAHEAPPTPDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZXJ6</accession>
    <name>A0A0D1ZXJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237613.1">
        <property type="nucleotide sequence ID" value="XM_016378936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZXJ6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZXJ6"/>
    <dbReference type="GeneID" id="27331674"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04591"/>
    <dbReference type="HOGENOM" id="CLU_004184_7_2_1"/>
    <dbReference type="OrthoDB" id="4106239at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="48"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="618" mass="70578" checksum="C8D23936952523E1" modified="2015-04-29" version="1">MALAPSIWPPVDPAKGEFRILVLDDYDDPDEAISGHLQIASVHDNAVYDAISYAWADAGDFRTIYINGQQHAVASTLTINMRHCQIKTGTKAFWCDAISINQLDNDEKSQQIQIMHHIFAGARIVRVFFNPDSSYSPYVERAVDVLLQTVEHSDLQAAEIDGQPMNATHIEWLSGLRHDAWWTRVWVVQEFVLAKELVFQFRDKFFDVEVLNKPKIRQLPLALSMFQVGESRLSTELLQKCCRSFAQGVNNLLWYRNFPLDRRHGLEEKHMSLLTNILFEIRRRHVTNPKDRIFGILALVNRILGSSLIEPDYTKELRDIFALFTFELIEKSRSLIWLLQCHHTTNSLIGLPSWVPDYSSRYNFEVEQGRAEFLIWSRFDASLGSVASAKLLQHSNTLSLRGVLVDTVAHVGHFHDRRAGARYLWHLQALMRWEALCREVFDRIESADYICGNQTVWKAYCKAVTGRLSKPDFSYDPELKYKYCTAEFGAHQDKIADHDGNNRVFEQVLKTIARRCLAITNKGYICLAPPSTKEGDAVYILAGGKGPFVLRPVCPDEKVRLPSQNSYNPFHMAVGYKSKLTSTQCRLIGDCYVEGVMKGEFIKDHGLGLDDFEDVVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYC9</accession>
    <name>A0A0D1ZYC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237868.1">
        <property type="nucleotide sequence ID" value="XM_016379191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYC9"/>
    <dbReference type="GeneID" id="27331930"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04847"/>
    <dbReference type="HOGENOM" id="CLU_031002_0_1_1"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="409" mass="44820" checksum="8A97E9282490E608" modified="2015-04-29" version="1">MASSRQYDIVLLGATGFTAGFVAEYIAMNLPIDLRWAVAGRDTKKLESLRGKLFDLNPGRSKPGIEQTNVKIDDVSTLASRTKVLINAIGPYTCYGEAVLSACAMSGTSYVDFCTETPWLEEMISKYSDIAKQTSARIIPAIGNSSSPSSIVAYLLSVQYRKMHDRPVEDIRCSYELKINGISAGSLSSILEVVTHYGISPLLFPDPYRLCSTSKKPRSPTTRKPFLGHCKDERLGHLATSFGAPGNEAVVYRSQHLQPSVYGDRVSYHEFMPASSAFQAIMIHVFTRFMIILLCFGPVRALIGYLKPAPGTGPSKEVSQGEKIEVIAVTKNERDLLAKYSFHGPMYFHSALLAAEAAMALLDLWGADEQDRAGEDGERQYGILTPSCLGMPFVSKLKKAGVKIEVYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYJ5</accession>
    <name>A0A0D1ZYJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_04927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237948.1">
        <property type="nucleotide sequence ID" value="XM_016379271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYJ5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZYJ5"/>
    <dbReference type="GeneID" id="27332010"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04927"/>
    <dbReference type="HOGENOM" id="CLU_046315_1_0_1"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="490" mass="54358" checksum="1414B02EDD0E229D" modified="2015-04-29" version="1">MSLAICIDCLSRFRISTNTLTRSVKTASLLPQAASFHTSLIQNANVVKAKSSASKQHTLKFRGSQSARLKKKVRERPKVPPVGERKAQRRRIVLSNTNALEVADLETWSKEKMTDSQLVGQVVALDGELLDQLRDAKAFKRTQNWSLFRKPATLIRNETIAIGKEIEALTSSQDNKMVKHLVAGETHSGKSILMLQTMCMAYMNDWLVLSVPEAQDLMNNTSSYGPLRQKEGAPTPEEQLFIQPHLAQAFLERALYSNEAVLSGLKINHELPKNIQLKQGSTLRDLLKVGVDDHIQAWRVWQAFWREITEPGSNPRPRVLLAADSVDHWMGPSKYFDADHKVIHSQQFVLIRNFTNLIFGKQNASFANGGMVIFCSTGSNSPACPTFKLLINQMRAKARGVSATSPKFPLPVPFSKPDQRVLDLIPGSDNVGLVDLNGLSVPESKGYLEYFAKSGLLQARLDDAKIAELRSFSAGGIVGELAKFGSRIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A081</accession>
    <name>A0A0D2A081_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_02685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238613.1">
        <property type="nucleotide sequence ID" value="XM_016377043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A081"/>
    <dbReference type="STRING" id="91928.A0A0D2A081"/>
    <dbReference type="GeneID" id="27329768"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02685"/>
    <dbReference type="HOGENOM" id="CLU_050757_1_0_1"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000002">
        <property type="entry name" value="Splicing factor 3a subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW18397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="235" mass="27236" checksum="68C3BFB5FEA4466F" modified="2015-04-29" version="1">MDYQNRAGSKFGGGGVASQSATNADRRERLRKLALETIDLDKDPYFFKNHVGSFECRLCLTVHQNDGSYLAHTQGRKHQTNLARRAAREQKEAQKDGQMLSGMMGVQVKKNMVKIGRPGYKITKIRDPLTRQVGLLFQLLYSEITPGVEPRVRFMSAFEQKIEEPERDYQYLLVAAEPYETCAFKLQSREVDRREGRYWTWWDADAKEFWCQVLFKTERDERYSNVPGLAPAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3V0</accession>
    <name>A0A0D2A3V0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_00084</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239728.1">
        <property type="nucleotide sequence ID" value="XM_016374452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3V0"/>
    <dbReference type="STRING" id="91928.A0A0D2A3V0"/>
    <dbReference type="GeneID" id="27327167"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00084"/>
    <dbReference type="HOGENOM" id="CLU_026244_1_2_1"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="50"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW19512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="398" mass="46285" checksum="895457A504ACD2D9" modified="2015-04-29" version="1">MSVQTTTITTTSTNTALPAEWYRSPALHELEKRAIFSKEWLLITHKNRFEKPGDYHTYDVAGFPFFLIMDRQKTIRGFHNVCRHRAFPVIRPDAPRSGTKSILACYYHGWSYGLNGKLAKAPKYENVEGFEKDENNLFPIHVRIDDRGIVWINLDAADTPRIPWETHLKGCDERPRLAKFNMDDYVYDHTWVMEGNYNWKAAADNYNECYHCPTTHPLFTVTTNLDKYRGEYKGAELLYFMEDKPGQNTHNFAPSWFYPNAAFNISDVFWYLLRSIPTGPTTVRNEYEVYRHKDATDAEFKKMDEFFKQVEREDKELCNGAQVNLNVGRYTAGQLEPKGEEGVLYFQNMVRQALKSHRDEEVKLGREIWPTRPAAAQSDDIQFCESLGSCGMAKETSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A6B7</accession>
    <name>A0A0D2A6B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240548.1">
        <property type="nucleotide sequence ID" value="XM_016375272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A6B7"/>
    <dbReference type="GeneID" id="27327990"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00907"/>
    <dbReference type="HOGENOM" id="CLU_107878_0_0_1"/>
    <dbReference type="OrthoDB" id="5153521at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="192" mass="21515" checksum="3A0C719AA7B4D110" modified="2015-04-29" version="1">MSDFRSEAKPYQRDKDHNRKWARGGKGQVTQPCTQHDEINSNCYKCIGRPKGQHLTAGEARYKQHHKNRVTSQTATLARKVFRNEVVDALDGPLAHVSDNSEEEDVVDASAAPLPPGADFLYSYDSRSGPRAGSDLLSNAVAQAVRRFENNETDKLVKKEYDVVDGKDMAEVSTDEDDLDLDFELIDHTHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A793</accession>
    <name>A0A0D2A793_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240858.1">
        <property type="nucleotide sequence ID" value="XM_016375582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A793"/>
    <dbReference type="GeneID" id="27328302"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01219"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="118"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="573"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="608" mass="66964" checksum="4E28753F14433CBC" modified="2015-04-29" version="1">MADTQEPPAESSRPESIQITPNHLVSMTAQDNQQPKEKSVDIDSDGQNHTPRRLSIEKATDSSRNTLKRRPWRPCVTDFNRILEARYTGNGTPSDPYIIQWLDDDPCNPKTYSMKRKTILSALLAFMTMCISLASSAYTGATESIMAEFNCSQEVFLLGLSLFVLGFGTGPLIFAPLSEALGRRNILMISMMFYTLWTGICAAAQNIQSLIVFRALAGVIGSTAIVVPGGQIADMWDAEHRGVVIAIFSAAPFLGPTLGPMVGGFIELGASWRWLFGVLTLYAGVLTILGLLIVPETYAPVLLRERAKLLTKVTGRAYMTKMDMDNPLSFKKMLTRSLVLPWALLFREPIVLLLTIYTSVIYGTLYLCFAAYPIVFQRGHGWNAGVGGLAFLGMLVGVFVGVAIIIYDNKRYTRIHRETGGFAPPETRLPTVILGGVIAIVGLAWFAATASPRIHWIVPILAEVPFGAGFLLIFMSCMNYLIDSYVIYAASMMAANSMLRSAFGAVFPLFTVQMYDSLGTRWGSAVPGFIALACFPFPIFFYKYGPVIRRKCKYSAQAARYLDSLKSDLERQRSRGEVQDLESTSVKHDNESSGAVPVSISQQTLKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7P5</accession>
    <name>A0A0D2A7P5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241028.1">
        <property type="nucleotide sequence ID" value="XM_016375752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A7P5"/>
    <dbReference type="GeneID" id="27328473"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01390"/>
    <dbReference type="HOGENOM" id="CLU_1547586_0_0_1"/>
    <dbReference type="OrthoDB" id="4149701at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="173" mass="18907" checksum="16ABFCBB1CA1AF3B" modified="2015-04-29" version="1">MGSSGGTTTNVSQSEWEKQHPRDVAQAGAEQRAHWGRGSAVTSDYSMYRTVARKSATTSHNTRTLCDADNVLKSAFTLTGEASSPSHQGQPSSTKPKIIIITTTTHADKMPHYHSTSGSSSGGERVYYNPRRDARGPKEPRPVPKREVVVIHHNAATQDDPVRTAGMSHNKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A976</accession>
    <name>A0A0D2A976_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_01917</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241553.1">
        <property type="nucleotide sequence ID" value="XM_016376277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A976"/>
    <dbReference type="STRING" id="91928.A0A0D2A976"/>
    <dbReference type="GeneID" id="27329000"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01917"/>
    <dbReference type="HOGENOM" id="CLU_015166_3_0_1"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="111"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="217"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW21337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="317" mass="33982" checksum="55FA91B922861FC9" modified="2015-04-29" version="1">MTEQNVALHEAPAPLVTSPWTRSLIAGALAGITVDFSLYPIDTIKTRLQSNLGSSHVSTLPRHTVAGTLRSMYAGLPSAMLGSMPSAAFFFLVYDGVKRSLAHDPTRPSSTQAYTHMLASSLGEIAACAIRVPTEVVKQRAQAGLFGGSSLLAVQDVLALRKTDGLPTMVRELYRGAGITIMREIPFTIIQFSLWEYFKAAYSARQHKIKGRHEGLVTASESAVFGSVAGAVAAGLTTPLDVLKTRTMLARKETGTSSSKTRAGPLDALRQIWHVEGPSALFRGFVPRVGWISTGGAIFLGTYQYVSNYLAADAPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AA42</accession>
    <name>A0A0D2AA42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241838.1">
        <property type="nucleotide sequence ID" value="XM_016376562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AA42"/>
    <dbReference type="GeneID" id="27329285"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02202"/>
    <dbReference type="HOGENOM" id="CLU_2622054_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002248616" evidence="1">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="78" mass="8759" checksum="CBCB26A20810F5FA" modified="2015-04-29" version="1">MHFAKVLVFSFIGAALAIPSPFEAPKPRIITRDVLKLEKRDFDPTVISERPHPNNPLMYESDNGPVCCESDWCGALCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXI4</accession>
    <name>A0A0D2AXI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_10455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231371.1">
        <property type="nucleotide sequence ID" value="XM_016384769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXI4"/>
    <dbReference type="GeneID" id="27337538"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10455"/>
    <dbReference type="HOGENOM" id="CLU_041298_1_0_1"/>
    <dbReference type="OrthoDB" id="4472872at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF3">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="3">
        <location>
            <begin position="64"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="401" mass="42779" checksum="DAF90D5A41C504F3" modified="2015-04-29" version="1">MATEHTPLLGRYSYGDSDEYPPAAVDPHEQFCMMVGIPSSAPDADQQRRYQQHQSVPRKSLYGRVTRQLRHQTWTYYTTASLSNAMLLSQVVLGAALTALGASESSHILITVFGAMNTVIAGLVAYLKSRGQPMRARMYRDDLERVVDEIENSEVMWLGISRHVHGYDEIDTDDGQVSVRSEVARLTRLYDRAVRNNTINNPDMYMANGGGYDGHGAQLRSRPGVALPPQLQGGGGGAVVPIAAAPQPVVVAAPVVQPNLPQPTTTAPAQNETVRDPDESPATAPPKPKEADDGGKKEQSKKETDEDNKDSKADNSGGDNGTSREKDKDGGKDSAEDTNTNKKEGDSSSSSSSSLAPKGGAADPSPVEGSSSQPQSPPTPPTEHDPDASPASDPNVPLKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYB4</accession>
    <name>A0A0D2AYB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_10695</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231611.1">
        <property type="nucleotide sequence ID" value="XM_016385009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYB4"/>
    <dbReference type="STRING" id="91928.A0A0D2AYB4"/>
    <dbReference type="GeneID" id="27337778"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10695"/>
    <dbReference type="HOGENOM" id="CLU_039478_6_1_1"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000009">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW11395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="355" mass="38007" checksum="E93DD3FE5F9777AE" modified="2015-04-29" version="1">MQPKAVEKNTPANGHTNGHSANGHSKGYDMASPSTIHQKFLTSPADLGVVLVGFSGGQCKPGVDAAPTALVSAGILEQMRDELGYTLHGDNSVHDYDQLRPQSDPDHRGMKNPRAVSAVTQGLAQQVYNQAREGRMVLTLGGDHSIAIGTIAGTAKAIRERYNGRKEIGVIWVDAHADINTPETSESGNVHGMPVAFLTGLAKSEEKDIFGWIDDNQRISTTKLVYIGLRDVDRGEKKILRDNGIRAFSMHDIDRHGIGRVVEMALAHIGADTPIHLSFDVDALDPMWAPSTGTPVRGGLTLREGDYIAECVHETGQLVAMDLVEVNPSLEVAGASETVRAGVSLVRCALGDTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZE3</accession>
    <name>A0A0D2AZE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial outer membrane translocase complex, subunit Tom5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_09307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232249.1">
        <property type="nucleotide sequence ID" value="XM_016383626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZE3"/>
    <dbReference type="GeneID" id="27336390"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09307"/>
    <dbReference type="HOGENOM" id="CLU_209440_1_1_1"/>
    <dbReference type="OrthoDB" id="4150500at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019603">
        <property type="entry name" value="Tom5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10642">
        <property type="entry name" value="Tom5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW12033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="49" mass="5502" checksum="ED5C6C587BB0A496" modified="2015-04-29" version="1">MFAGPQEHLSEKEIREGEAKAAVGVQTFTAACIALWFSPHVIEWARKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B010</accession>
    <name>A0A0D2B010_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232529.1">
        <property type="nucleotide sequence ID" value="XM_016383906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B010"/>
    <dbReference type="GeneID" id="27336673"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09590"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF158">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14490)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="562" mass="60525" checksum="62542CEF24E835F5" modified="2015-04-29" version="1">MDAKGRELDVITPSVRAQDVPIEACPVDRPSTMDDTVVPIKHRSRLRITMILTALYLSLFVAALDATIVATALPKITADLHSAAGYVWIGGAYLIANAAASPIWVKFSDIWGRKPIFLVALVVFFASSIICAAAVDMQMLIVGRSFQGAAGGGLICMVNVGISDLFSVRERSLWLGLCEGIWAFSGAVGPLLGGAFAQYASWRWCFWCNLPISGVAFLLIVFFLDVHNPRTPAMEGIRAIDWFGCLSILGVTVMLLLGLDLGGAVYPWGSAKVICLIVFGALMVLVFIYSEKKLAKYPVIPLSLFGTRNVATLLVTFFHGMVFMAPEYYLPLYFQSVMESSPIRSGYLLGPLIVATAVTGVLNGVFIHRTGQYRPSLWIGSVLLALGTGLYLMLDAESSVGMVIGFEIIGGIGSGLLFEPPLIAIQQGVHQDEVGTATSTQSFIRSMALSLSVIVGGIVFEQSMDIRRTSLIAAGLPPSVVEKLSGKNAGANVDVGRNLPPMQDRAVKDAFAWSIRNMFIMFTVLGAFNIVASLFINHTKLSTEHRETVTGLKSKDKAPSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B055</accession>
    <name>A0A0D2B055_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS8m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_09625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232564.1">
        <property type="nucleotide sequence ID" value="XM_016383941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B055"/>
    <dbReference type="STRING" id="91928.A0A0D2B055"/>
    <dbReference type="GeneID" id="27336708"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09625"/>
    <dbReference type="HOGENOM" id="CLU_107213_0_0_1"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000005">
        <property type="entry name" value="Mitochondrial 40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="170" mass="18824" checksum="E9A2070CCBB61B2C" modified="2015-04-29" version="1">MSLVHLANTCSHLQNASRARLGLTSIPDTKFHLGLMLALQNSGFISTVVRGGPEPPPPHKLLSHPSSSDPNHPVEPVTRHNISSRRLWLGLKYWESAPVLSKMSLVSKPTRRIWMDVSGLQKIVLGKTSGYVKGLTRTGECMYVSTDRGIMEARECVERKLGGMLICRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1G9</accession>
    <name>A0A0D2B1G9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232994.1">
        <property type="nucleotide sequence ID" value="XM_016382291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1G9"/>
    <dbReference type="STRING" id="91928.A0A0D2B1G9"/>
    <dbReference type="GeneID" id="27335048"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07965"/>
    <dbReference type="HOGENOM" id="CLU_003487_2_1_1"/>
    <dbReference type="OrthoDB" id="4120671at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="588"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW12778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="79021" checksum="613074FE0AD9F5C4" modified="2015-04-29" version="1">MPQIEIERSTNGHTDNILSTSALPWMWDNNFFSTDPAPDFDDDILMDLDLDWTSFVQLDYDLNCNDPHVGSPRYTRGPDDSNSGFRPRGPSVREFFSQSLWLWDPDARDSASTEETPHLSEADERVILSTVHVNNASTDKGTGLSPWSAGFSCRSDTRDALLLMVQSNSARTSAVRCFPSAEVLNFLLKAFAFQEALSRCSLLHLPSFKGDSCKIELLSGLIIAGSTSFSNPQIWKLGLALQDPTRIALYKVLDRQALTWQNMELLQAQILWIEAGLWSGVRCNMEVAESAANSIPTMIRRTGVYNLMSLENTWVPLPQDDDNTLKSKWAKWTQLESFRRCVIRAFINDIQASAAYARSPRFYSTEIMFGLPSAHDLWNAPDHLTWTTALLAKRTGTEQFKLTLRDIFQDPSTLRSLSREYDRELCAFSALHCLWPQIVALQDSKSLHRGHRSNKRPSQNSLWLEAQRQDLYQRLADIRDTSSVMGILTCEARVVCEIFMMALYVSFVDIEKLVGRFGLDESRLTTPNLRTWSDSDEPWHAMWHAGQVLKAAQDMKPSQLRGFYAVAVYQACIVLALPFMLEAISKTSRRQSPEPQNDAQAGCEQHTHNRQEIPRPREETNLVVLNGEENMQVRMYLLNGHGRPSLILGNEVTPLSDISVVPLIISKILESNHGTGADRLPPMSEKLVALVKELTKLTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2N4</accession>
    <name>A0A0D2B2N4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233091.1">
        <property type="nucleotide sequence ID" value="XM_016382388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2N4"/>
    <dbReference type="STRING" id="91928.A0A0D2B2N4"/>
    <dbReference type="GeneID" id="27335145"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08062"/>
    <dbReference type="HOGENOM" id="CLU_063954_1_0_1"/>
    <dbReference type="OrthoDB" id="5358398at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="275" mass="30508" checksum="FA7FFA7DCA06E66C" modified="2015-04-29" version="1">MAQRAHDLALSVVNGVRHDSRKRYLAIAVAAFTSLTIGRAAWKDYRLYRSYGPGGLPSNAFGWAVSNILRLFGIDMTDVSKAEKDADQRSWLGEDWPSKKSRDGSRPSVGPHPIPQRQLDQYGPKDVQQKFLDDFTTLGKQNPDLVTFKRSQYERHTDAAMWVVESSPVYALRRSHTREVSHIHTNTDYSAHVVLSPRDAAKVIRAGWGQLHALSGVSLFGKTAVPPGYVMLYSARSDDEVDVLIEIIKAGIGFMTNASVVQPSVVEDNQNLASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3S1</accession>
    <name>A0A0D2B3S1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233729.1">
        <property type="nucleotide sequence ID" value="XM_016383026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3S1"/>
    <dbReference type="STRING" id="91928.A0A0D2B3S1"/>
    <dbReference type="GeneID" id="27335784"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08701"/>
    <dbReference type="HOGENOM" id="CLU_034107_0_0_1"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="59441" checksum="63E17D503B77CF3D" modified="2015-04-29" version="1">MASPPCQNDAEPLFLPITYNNLSTDGQGARAWGIALDVGTPNQTFSLYPSIWDTTVLANVRHCTSKDDLICLAANGGLYDPKLSLTSANPEFSTWNGTVSGTDSSIFTFYNDVIDIPQFNDTRIWGYPFVTDDASLWGISSLGIGPNSTFLQAAVDADAAPSMSWGLWVGSRSIDEPQDGLLMVGGYDNARVAGDFFTDVSTLECPVCLQIQDLSWATENGTIGLTNATTNNFQVSLNPISNSIQIPQELFKAFGIATNGTYDQQLETYTYAGLSPPVGNLSFTIKGGYKTSIPANELFRFHGEYNSEGELVIANDTYQQAFVYSYTNQDTSDLHYTYTWGLPFLTMNYLILDVEQQQFRLSEAIRQDFGKEGGVFPRKLCSDPPVGPGGGGDGGGDGGGTNIGAIVGGVVGGVAGLSLLVLGVFCLWRLRRRRSSSTRGTSTRRVPALPMTYAAVQTGAAAAGYDSRLTMSHPPQGTVFYPTQAPAYGYTMTGHPSSFGQVQQIYHPSLGGLVAQELPPSDTNASELKSARSQRAGSRDRDGSVSLKRRFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B420</accession>
    <name>A0A0D2B420_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Upf1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_08618</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233646.1">
        <property type="nucleotide sequence ID" value="XM_016382943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B420"/>
    <dbReference type="STRING" id="91928.A0A0D2B420"/>
    <dbReference type="GeneID" id="27335701"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08618"/>
    <dbReference type="HOGENOM" id="CLU_001666_4_0_1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:RNA helicase activity"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DNA2/NAM7-like"/>
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        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DEXDc"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="17">
        <location>
            <begin position="79"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="15">
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            <begin position="87"/>
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    <feature type="region of interest" description="CC/SHH/C" evidence="15">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
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        <location>
            <begin position="147"/>
            <end position="177"/>
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        <location>
            <begin position="1047"/>
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        <location>
            <begin position="48"/>
            <end position="60"/>
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    </feature>
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            <begin position="68"/>
            <end position="78"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
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            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
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    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW13430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1072" mass="118034" checksum="F375A6B7A0B9D873" modified="2015-04-29" version="1">MEAFSNMGNHLVSNSAAAINASDDISTVDPDESVLSLAKGPRRRQHDDDESESVEEDDLESLASAAVDGKKQATKAEEEKELPPHACAYCGIHNPSSVVRCLTCSKWFCSARGNTSSSHIVNHLVRARHKEVQLHPSSSLGDTVLECYNCGTKNVFLLGFIPAKSDTVVVLLCRQPCAAMPSSKDMNWDTSRWQPLIEDRSFLSWLVAQPTDQEQLRARHLSPQMIAKLEELWKENSAATITDLEKASNIDDEPAPVLLRYDDAYQYQNVFGPLVKIEADYDRKLKESQSQDNLIVRWDLGLNNKHLASFILPKLELGDVKLAVGDEMRLKYTGDLRPAWEGVGYVYKIPNNQSDEVTLELRAKGDHKSVPTECTHNFTADYVWKATSFDRMQLAMRTFAVDEMSVSGYIFHRLLGHEVAAAPMKTQMPKKFSVPGLPELNSSQISAVKSVIQKPLSLIQGPPGTGKTVTSATIIYHLSKINGGQVLVCAPSNVAVDQLCERIHRTGLKVVRVTAKSREDVESPVRFLSLHEQVRMNDSNVELSKLNQLKSELGELSSQDEKKYKSLTRSAEREILQNADVVCCTCVGAGDPRLAKFKFRTVLIDESTQSAEPECMIPLVLGCKQVVLVGDHQQLGPVIMNKKAAKAGLNQSLFERLVTLGCAPIRLNVQYRMHPCLSDFPSNMFYEGTLQNGVTAEHRTRREIDFPWPVVQSPMMFWSNLGNEEISASGTSYLNRTEAANVEKIVTRFFKAGVKPADIGVITPYEGQRSYIVSSMQANGTFKKELYKEIEVASVDAFQGREKDYIILSCVRSNDHQGIGFLSDPRRLNVAMTRAKYGLVILGNPKVLSKHPLWHYLLLHFKGSNCLVEGPLTNLQISLHQFSRPKQSYRGPQRYQMAYNHATHMASGMMNGRGGPRDGGSVVGYIPDDVSSIHSSAMGGVGVPAGYPPMFQSFTADTWPSLQNANGRRSNGVKPRGVPGSVAGESTVATESDVTGSVIGQGGVSLDQLSIHDVTKHASYNQADRLKRYVEGGVPNAGYMGGSSRFGKGMHQDEDAQSVSTAFASQVGGGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4I2</accession>
    <name>A0A0D2B4I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016383098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4I2"/>
    <dbReference type="STRING" id="91928.A0A0D2B4I2"/>
    <dbReference type="GeneID" id="27335857"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08774"/>
    <dbReference type="HOGENOM" id="CLU_012494_6_2_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="119"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="385" mass="43011" checksum="6BD2C748BB0F4F68" modified="2015-04-29" version="1">MTSHDDRMHDVVHGGSHTPAPPPHIPLQPSVLDRLDPAFIKLYNTHIANGPGWSTDLNILRQNYSSLYAYASAPATGVGGIGETRVPGWNKYPGDINIRVYVPPGEELGRRNVWPVHFNFHGGGWAVGDLETDAHLCHHICASVPCCVIDVEYRLIPEYPFPVGIMDGFSAVLHILHNHNTFSIDPDRFTLGGESSGATIALILNHLLRDHGMGHKLKGVVAGTPTISDVKKYATPDMSPWPSMREAEIAPLLNWEKLKWFDTFKWMSLASQNSTKPKEQKRDISWFADAMKAPDFQSLAPLTYLATAEVDPLRDEAEAYAKRVEEAGNTVVMKRFKGVPHHFMHMDRLLTQGHDYVQDVIQHIRQCLYPRPPQPPPKPSTPPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4R6</accession>
    <name>A0A0D2B4R6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233916.1">
        <property type="nucleotide sequence ID" value="XM_016383213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4R6"/>
    <dbReference type="STRING" id="91928.A0A0D2B4R6"/>
    <dbReference type="GeneID" id="27335974"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08891"/>
    <dbReference type="HOGENOM" id="CLU_066685_1_0_1"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="275" mass="30354" checksum="EF8E7AE523CC587B" modified="2015-04-29" version="1">MLFFGKSLLGAGYVVLNVIRAMNIIALLSAMAASSVMLVKTFIVSKFFFFDACEHIIRIVMSGFLIVTELPLFKGYISRNWPLFSPRSSFIMLGIVMIFLGNSILGNLNKQATSQESLGLPFWRLVIASGIVVLVMGPINILASFVFRDKKAHLTARQVRSHGAVASHKADVEASTPKPPNRRSHYRSFFLGSKRDTLPPYNVRKGTKQNDMVETPKMHLAISSPFQSQDATAQSPGGASSKYSQSPKSERYFTSPELNRPDLAHHPAITHGQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5F6</accession>
    <name>A0A0D2B5F6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 14">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_06919</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 14"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234354.1">
        <property type="nucleotide sequence ID" value="XM_016381252.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2B5F6"/>
    <dbReference type="GeneID" id="27334002"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06919"/>
    <dbReference type="HOGENOM" id="CLU_005327_2_1_1"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="214"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="536"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="269"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="830"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="950"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1065"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1171"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="116"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="881"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1079"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1180"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1213"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW14138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1311" mass="143256" checksum="6231A2DA926B1F59" modified="2015-04-29" version="1">MPPLVSEEPDETSSLDQESVSGEVDVESNANEDLIGPTINVRVVAAAGKPMAKRNTEEVGERDTDSAHAPNPEDSALDEQLQRSAEEEGSDDDEAESSSPPRAEATTDSPVKGEDSEADADADEDEDDEANAVSDADDKDAEAESDTDADADEDAEAETDDPAQEDNSGDEESSDDATSDGKSQSSDESDSEDSSSQSEQGEEVAKETQTNHAEPECMFCDKTNDTASADADTLLACSGCGKHAHLRCLQERDEVENDKTGAWQCPDCLQQPGQSESPKEQTVRSKNSAPRLVRDLLPVTRGVQKPGSHSIFAQPLIQEGEDGGRALRKRKSPTEEPPPTEKRRRKVTPRALEAISVDSKAEEEKAVAHSTRASQKITKPVARILQHRPFNKAPPHKFILAFHLGQSKIEEILNKPPRPGRRKAAPVRERKKVPKIPAPVYQPPVPKFPALPTHHLIFPSAFTDREAELNAKPYGGILTEAEADTSRSLPQLKDREIFEIARKEAEEERRRTSAAAEAEINGDKEGTSKPNRTVSGPPTKIKCIQFGKFVIDTFYAAPYPEEYSHESRLFICEFCLKYLPSEFVAYRHKLKCPAKHPPGDEIYREGTLSVWEVDGRKKTEYCQCLCLMAKMFLGSKTLYYDVEPFLFYILTEYDEFGYHFVGYFSKEKRPASQNNVSCILVMPIHQRKGYATFLIDFSYLLTRIEGKEGSPEKPLSDMGLTAYRSYWDLTISRHLLDIGLKPFSTRTLMARTGMTADDVIHSLERLYAFVKDPVTKTYAVRYDKKLYERIVDEFDSKKHRKLRPEALIWTPYIMGRSDQATLDGQHLQALAPRDDDEDEEEKEETGPGEVVSKAGKSLTEVDTEVDVLDSGNISPRSRAKSTTAVSRRASVTAAVDSDTKAESQDDPLTNDLGVVAPGPPSTDAMNGTVSTQLTQPALKVNGLSVGLVNGDGMTSEDSRNAKSENNDAADVQAEEGSKVAAHKQDTKMPEPPLTGYALAYRTLNIPPTRFQIDPPIHPAMLRQRSTKKRNLTTAFGRAGSGSNANGNTTHTTPAVAVRSSPRHANTVANVNGGGGGGASTTTRTRTGSLDMGKGKETLSVPNTPARRSSRRSALANSSTIEVLTPFNAPAASQAGPSTRTTRARSSRNDSTTVDIEDGDVIEVSTATAAASAKAVHAEVDAEADEDVDAPADEDEDEEEEKVNDKGKARANVVEEEDDQDAEADSSSGGDEEEDDENSEDEEEEDDDDDDNGEESEDETSDAVIPEEEESDTTGDDDGDAPADDDDDDDDDEDAEVDEDEEDDDEDDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5G3</accession>
    <name>A0A0D2B5G3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234364.1">
        <property type="nucleotide sequence ID" value="XM_016381262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5G3"/>
    <dbReference type="STRING" id="91928.A0A0D2B5G3"/>
    <dbReference type="GeneID" id="27334012"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06929"/>
    <dbReference type="HOGENOM" id="CLU_059028_1_0_1"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="6">
        <location>
            <begin position="44"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="304" mass="34322" checksum="8211FEC3C855CF62" modified="2015-04-29" version="1">MFIPSVRRCAPSIWKNTQAEMARATKFALNLEGLTLPTTPKPIFDFADPETITTLKTMTDRSVGGFSTAELVQRPADAASQTPAHILFRGNISTKLPANRPDINRTGYAAWRNQDRGRTLFGELFWSVDSYMYLALRVKSDGRKYFVNIQTDSIVESDIHQHRLYTKYHKGAEGPDSPAQWETVWIKLHEFVRTNHGVVTEPQSEMLRQKVKSFGIGLIDRQPGPFELGVAAMWATNLNERGQVDGRTGWEHGDQGSARLSEVTAEKLAQKEEEKRNLPQQKKGFRERVPHFGKVGTHDTSGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5I2</accession>
    <name>A0A0D2B5I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234394.1">
        <property type="nucleotide sequence ID" value="XM_016381292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5I2"/>
    <dbReference type="STRING" id="91928.A0A0D2B5I2"/>
    <dbReference type="GeneID" id="27334042"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06959"/>
    <dbReference type="HOGENOM" id="CLU_037990_5_2_1"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002463">
        <property type="entry name" value="PRK01683.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="264" mass="29943" checksum="A9D0B3C274241345" modified="2015-04-29" version="1">MATKDWNAAQYLKFERERTRPVADLLSQVPLASPGRVFDLGCGPGNSTSVLLKQYPDAHITAVDSSQDMVNKARQTLPESVDVQLADLATFRDTASADLLFANAVYQWIPYDDRIRTFTELIMTQKPGGVFAFQVPDNFNEPSHVAMRAVAENGPWSATLNRLPEPPTRKPFQTPEELYNSLKPLCSDVNIWRTYYHHILDDHQAIVEWVKGTGLRPYIDPLSDEERKGFLEAYLGKIAEFYPPLVDGKVCLRYPRLFVVAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6B0</accession>
    <name>A0A0D2B6B0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234446.1">
        <property type="nucleotide sequence ID" value="XM_016381344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6B0"/>
    <dbReference type="GeneID" id="27334095"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07012"/>
    <dbReference type="HOGENOM" id="CLU_473290_0_0_1"/>
    <dbReference type="OrthoDB" id="4119909at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="619" mass="67623" checksum="C62B05BB9F548FF8" modified="2015-04-29" version="1">MAPSVPDNTSVKASTDPLNASVYDNMSTQSQMGSVESSPARTIRRVKSSPCLRDQISSDVPFITQRAYKAHVSICKNSITQETTERSQNAEQSRDRTCDTERSPSNTRHVEEHSEDNIYNAERVSPTPTIDKENFGSILSSFPPTPKRWSNATSHSRWPEPQLGPIIEQSSVTSGRTSHSLPRPVAIPTATQPTQAPWAIRADVPTVLLDPTSGSEETSIPAPNILGERGGFSASSESAAGPSTPYSSYPRMPMQSPPGSIETPPGLPSFGTREATTWRLRQGPLIRQILYHFVPYSDPSLDDRNYDEDPMPRHPALDGTGAIPLRNRNRQDQSGPSSTEAVTRTLAVEGLSRLLSTAPEQVDLPRASMPFRLYTSNVPGSLALADDGTHIRGEFGSRTSGHGVGRRQLECHPFGQANDVGEIVQEIDKACERVDMERLESQTVTPYAPTQGFGRISVTDSPDVSPGVATQQVSSDEGAGQAQPSPATTPSPPASMDANVEDELRAAIAHVLPHLMYSHTQSRMLHASETRLARPQLIRFSAYSPNSVAEPRPAFEQPRPYQENTEGGHIARNEGRKGRWWAPMTAWLKESSCGLHTCTWPRSRRSRMYSAPTGEYATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6C3</accession>
    <name>A0A0D2B6C3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234639.1">
        <property type="nucleotide sequence ID" value="XM_016381537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6C3"/>
    <dbReference type="STRING" id="91928.A0A0D2B6C3"/>
    <dbReference type="GeneID" id="27334289"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07206"/>
    <dbReference type="HOGENOM" id="CLU_023417_3_0_1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="40241" checksum="55E78BD31558D0BD" modified="2015-04-29" version="1">MLLEFDGLKDIALACGAAHLHTATGNMQLQEAGFAYYSRATSQVSRALSNIDWSRDQYNDAVSMTVTFLYIHGLFDMGTNKDVPKHVNGAIQLMNVRCRNSHSSPLARPIHRILWESILYQMFRQTVRHPFTIDFQPDLDFATKAESILRSLAFPDASLADNSPVIGFPLKLQKLMLEIVQLCKTLSRPEDHVLRRLHKEMKQWETSIPDDGCCSDDDNEVGIPGNRKQRARSFYEHSTSLHILAASLLLDWVSKSTAVSDPARRHVTPCSESWQVGRALQIMRCSRAKEDWSKCYLGSWPTLVIGYAVDSPEDVALIREDLEHRYQTLYCREELSFLAELEDVWQKKGILVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6Y0</accession>
    <name>A0A0D2B6Y0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234894.1">
        <property type="nucleotide sequence ID" value="XM_016381792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6Y0"/>
    <dbReference type="GeneID" id="27334545"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07462"/>
    <dbReference type="HOGENOM" id="CLU_1030716_0_0_1"/>
    <dbReference type="OrthoDB" id="5279542at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="270" mass="29716" checksum="67A82754ECB6E0A1" modified="2015-04-29" version="1">MLTKELIPGATYPTSYEMPEARSRPGPRMVRKYLSTILHTTSLVASLLGMSLFAAAIPRWNSNFFHNTGPNRGDWTDGMPLGPLVFALLYHAATLIYNHARRQRIRRQFARQSADAVTMADGGKPSLVIIHVLSSSLILAALFASLILAAYGSLFRFWRPAMRTQSGGVPCTMINVFARECQPVLYSVGRLQLAGIVFGIVVWAPEHDQAPAVRETSSVLSTTIVLVLVILAVRQNNGSPRWTNTLHDRHESRQIALDESAAGAPESRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7T5</accession>
    <name>A0A0D2B7T5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_07529</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234961.1">
        <property type="nucleotide sequence ID" value="XM_016381859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7T5"/>
    <dbReference type="STRING" id="91928.A0A0D2B7T5"/>
    <dbReference type="GeneID" id="27334612"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07529"/>
    <dbReference type="HOGENOM" id="CLU_041954_0_0_1"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="139"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="337"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW14745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="389" mass="43327" checksum="5362AAF4EAEBDE42" modified="2015-04-29" version="1">MTVNHIALPDADDDSPRAGLLSPWQPPRRSLSTGRSSPFVRSRSAAWRDEAIRNAERIQRRIVKVWSKMSVLQRVLSVIGLVILNVLAILFLIFNERIFGLLEPLAERWKHTTGGWTILWAITFLTAFPPVIGYSTCGTTAGFVYGVWEGWLILASATVAGSFCSFLLSRTVLRKWVERMVANDKRFAAFTLILKHDGLKLLCMIRLCPLPYSLSNGAMSTFPTVHPAMYALATAIVSPKLLIHVFIGSRLAVIARTREKMTMGDRLVNYSGIAIGATVGILTGVYIYRQTMARAKELEAEEANNIRDAVRRTGHLPPEYADDPEAQVAANALERDDDVMDYFDESSPNPQTEYHDEPTDDEDVFGRGDGDDEDIVDTISLHTQKGVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B996</accession>
    <name>A0A0D2B996_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235446.1">
        <property type="nucleotide sequence ID" value="XM_016379619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B996"/>
    <dbReference type="STRING" id="91928.A0A0D2B996"/>
    <dbReference type="GeneID" id="27332358"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05275"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19143">
        <property type="entry name" value="AKR_AKR6C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="109"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="431" mass="48095" checksum="815E88C2791D2AB9" modified="2015-04-29" version="1">MTSIAETSPQLRGQGGQQGATVCPPRNPGLRYIFQIGIHTTFNAGHKKRQKQHLSRPICTPPPKINKTEATSVNGLKPSFHFKGVMAPKFDRANMKYRFLGPTGLRVSEISLGSWITFGGQVKKEDSLAFFREAWTHGINFFDSAEGYLEGKGEESLGMAFKELGWDRSDFVVVTKIYWGGSGPNDVGLSRKHILEGTAKSLKRLQLDYVDVIMAHRCDPATPMEEIVRAFTHLINTGRALYWGTSEWSAQEIESAHSVAKNLGLIAPICDQPQYNMFTRSRVEQEYLPLYEKYGYGLTIWSPLASGILSGKYNDFNVPEDSRLAIKEDQFMVAFKEKLSTPEGRAEIEKVKKAGEIAKALECSMSQLAIAWCLKNKRVSSVITGASKTSQIAENVKAVQIVDKITEEQMKQIDEIMGNKPSGVEYFGRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BB68</accession>
    <name>A0A0D2BB68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236076.1">
        <property type="nucleotide sequence ID" value="XM_016380249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BB68"/>
    <dbReference type="STRING" id="91928.A0A0D2BB68"/>
    <dbReference type="GeneID" id="27332993"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05910"/>
    <dbReference type="HOGENOM" id="CLU_006033_1_0_1"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="50"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="286" mass="31523" checksum="3863D0EAA3D1123F" modified="2015-04-29" version="1">MAPALDVYDSSSKENRSVGALGKTVSGKTLKIRAYPKFDSLEEERLYRKQHLAAAFRVFADRGFDEGVAGHISVRDPILRDHFWLNPLSTHFSQICVSDLILVNEDGDVVIGDEPINAAAFAIHSEIHKARPDVDAACHAHSVYGKAFSVFGRELDMMTQDSLRFYRSHAVYDNFGGVVLDREEGRRIARALGPAGKAVILQNHGLLTCAKTVDAAAFWFISLDKTCHAQLLVDAASAGSGHRKKLISDEEAEFSYAQVGTDEKGWLAFQGYYDEQLAKTNGAFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCC0</accession>
    <name>A0A0D2BCC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_03806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236834.1">
        <property type="nucleotide sequence ID" value="XM_016378157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCC0"/>
    <dbReference type="STRING" id="91928.A0A0D2BCC0"/>
    <dbReference type="GeneID" id="27330889"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03806"/>
    <dbReference type="HOGENOM" id="CLU_033465_6_2_1"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30735" checksum="C89D2011E7EEEF20" modified="2015-04-29" version="1">MSDDDCGRITYGYVDPNWPRPDTDDSACIIIYGYVPSLALGILGVVLFTAALALHLWLLIRHRTWYFSPVVVGLVMEIVGYAFRLLASQKNPYSVSYFVAQYFCIVVAPVFFSAAIYTILSVIIKVAGSKYAPLSPRLIMWIFIVCDVVATAIQITGAALVGRAYSDQKDPTTPNNILLAGLAFQVFSFAIFILCFVLFIYRARRILGNKLKVFSGAVMVAALAVYLRTCFRLAETAEGLLEYLPTHEVFFGCLEFLPVVVAVYILVWWHPGRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCH9</accession>
    <name>A0A0D2BCH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236899.1">
        <property type="nucleotide sequence ID" value="XM_016378222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCH9"/>
    <dbReference type="STRING" id="91928.A0A0D2BCH9"/>
    <dbReference type="GeneID" id="27330954"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03871"/>
    <dbReference type="HOGENOM" id="CLU_062974_1_2_1"/>
    <dbReference type="OrthoDB" id="2017544at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.200:FF:000002">
        <property type="entry name" value="Probable transcriptional regulatory protein CLM62_37755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="4">
        <location>
            <begin position="45"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="3">
        <location>
            <begin position="124"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31769" checksum="0099C2921274BF07" modified="2015-04-29" version="1">MGSARVPLRSQRFYSTPWGSLIHEPCSVSWRRPFSGAVPKLSGHNRWSKIKHDKARTDARTSKLRTQLSSDIIIASRLGGPDPSLNPRLNAAIVAAKKGQLAKSSIEHAILKGQGKSPSGATLENLIIEAMLPHGVAALLECQTDNKARTLQDIRFILSRAGATVTPTAFLFEKKGRITFEQQENQENKIGVDEALEDAIEAGADDVGTDEDGRLVIDTPPEDVMDVAKKLQQKLSLRVEKAEVVYDPNEESMVTLTPEQEEEVGKVLEALEDDPSLQNLYVNATSQPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDA4</accession>
    <name>A0A0D2BDA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03758</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236786.1">
        <property type="nucleotide sequence ID" value="XM_016378109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDA4"/>
    <dbReference type="STRING" id="91928.A0A0D2BDA4"/>
    <dbReference type="GeneID" id="27330841"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03758"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="57859" checksum="5BD5D32F0603F028" modified="2015-04-29" version="1">MSDTGLCTISVWAPFGLAIAAYGALLLYRLFFSPLSKIPGPWTTRISGIPEASALKDKRRTEWVNTLFAENPGSVAVRTGPSSVSFNHPDAVKAIYGHGKGAEGFGKSSWYDAFSTTGESLFSTRSKKRHAMKRRMVAHGFSMQSLYSFEPYVDITMQAFLRQMDELARTQQPFDIYFWFELFTMDLMGELAFGKNFGALQSGKPVRYSTLVELSQRFANLCGMLPFGKYNVQVLSWVPLPYIQKLYRARLEYLEYARKALEGRFQDSRQQLLPSGKPRQDIMQRFIEAQDPETGARMDFPELRAEASSLMVAGASTGSVTMNWMTYYLSKNPTVKERIIRQLEDMFPENLDGSRPASFAKLQHLSLLEATEIECLRMHPPIGYAMPRLTPPRGAVICGTYVPGNVDVGVPAAIIGRNPAVYRNPDSWQPDRWLDENADMATMKLCFLGFGYGSRQCIGRNVANQFVMKMMATLLLRYDIQLEDPNLVLGSKEFTIIKPDKKYNVILRPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDN1</accession>
    <name>A0A0D2BDN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_04224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237249.1">
        <property type="nucleotide sequence ID" value="XM_016378572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDN1"/>
    <dbReference type="STRING" id="91928.A0A0D2BDN1"/>
    <dbReference type="GeneID" id="27331307"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04224"/>
    <dbReference type="HOGENOM" id="CLU_066933_0_0_1"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036524">
        <property type="term" value="F:protein deglycase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017283">
        <property type="entry name" value="HchA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003168">
        <property type="entry name" value="PRK04155.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF20">
        <property type="entry name" value="PROTEIN_NUCLEIC ACID DEGLYCASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037798">
        <property type="entry name" value="Chaperone_HchA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="8">
        <location>
            <begin position="77"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="294" mass="32672" checksum="0B38D527FE5B91BA" modified="2015-04-29" version="1">MASTSSDRKPVPDRAEHDAWFPSPYSLTQYVSPKTNFDGVDHPNAYKGGKWRILTIATQERYLQMANGEFFSTGNHPVETLLPILHLDAAGFEVDIATVSGDPVKLEMWAFPKEDEAIKKIFEKYKPKLRQPLNLDRVWDDGFTKDTPYIGIFIPGGHGALNDIPSSPTVGKILRWADANRRYVISLCHGPAALLAADVDKPEGTKFIYSGYKIDVFPDALDSGANIDIGYIPGKMTWLVGEELRKLGVIPINKEITGETHRDRYLLTGDSPLASNNLGKLAVRTILDELPNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE18</accession>
    <name>A0A0D2BE18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237434.1">
        <property type="nucleotide sequence ID" value="XM_016378757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE18"/>
    <dbReference type="STRING" id="91928.A0A0D2BE18"/>
    <dbReference type="GeneID" id="27331492"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04409"/>
    <dbReference type="HOGENOM" id="CLU_023620_6_0_1"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.520">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.90">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10910">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="51"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="417" mass="45884" checksum="C8CB454C07B01261" modified="2015-04-29" version="1">MSSFAIKNVRIFDGDNVLEDADVIVKDGIIEQVGPDLNPGDLPSISTPGYTLLPGLIDAHCHPDRELRLLEQSFRFGITTIMDMHNVHENAVQLKRWAQARKDVPDVKSCHYAATIKGGWPAWVEMKLPGIEPGRFDNYPNVNSEEAAEAYIQKAVEGKYDYIKLMHEDGRALGIAEGQIEKPTEAVQEAVVRAAHKRGLKVVGHALSLEDTREILRAGVDGLAHTFFDEPMTPEIIELHRRNNVWVNPTLACAGALTGESLDIFKQFSEDDRVKNKLSTGDIELMHHCLHLKAPGAKWEYAIDSVRQLRAAGTDIICGSDAAAGAPGSVFGANLHIEMYLLVMKAGLPAQEVLRGATSLTADLFGWNDRGRIAEGLKADLLLVEGNPLSNITDTLNIRAIWRDGVKFEGHQGFPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEX4</accession>
    <name>A0A0D2BEX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230135.1">
        <property type="nucleotide sequence ID" value="XM_016386003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEX4"/>
    <dbReference type="GeneID" id="27338778"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11695"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF81">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW09919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="57786" checksum="DCB1996A1A695A1B" modified="2015-04-29" version="1">MGELQAMTINPATSSHAETVGGNVNEDKVSVQHADNALAFAIEHQNITWTSEEEAMVLRRIDLVILPLLFFAAIIAYSDSQAYGFAAIFGLVQDMNLFVPKIQHGEIYLDLSRYQWTAAIPTLGSVAMQYPLLLLVQHLHIGRFSGGVIIFTGLLTLLTIVCKNFADIMALRFFTGLSTLTQPLSILMTSMWWKSPEQPLRAGIYISGTALGSLIGQGIDLGAIDIKGAYTTSPWKWIYVILGPITIAFGFVMVVLFPASPMNAWFLSARHREIAVRRLLQNNTGLKARKWKWSHLREAYLDPQLYALCIYSFTFAFVNQSIGSFVGFLVTSFGYSNKRSIILSMPASAVAVVSLTTSGYLGSRFPTKRLIIATSYLIPAMVGNIMLWKSDRSNKGALLGGLYISTVVYGALVQMFALLSSNVAGYSKKTVVNATVFVFANCGAFAGPWAYKSDEAARGYPTGQISTLSLLCASAAGFVLLRLHYHRANSKKARLRDEHPEYITDPSIALADLTDKENPIFRYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BG33</accession>
    <name>A0A0D2BG33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_04744</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237766.1">
        <property type="nucleotide sequence ID" value="XM_016379089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BG33"/>
    <dbReference type="STRING" id="91928.A0A0D2BG33"/>
    <dbReference type="GeneID" id="27331827"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04744"/>
    <dbReference type="HOGENOM" id="CLU_065642_0_1_1"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW17550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="270" mass="30542" checksum="255745D95EC67BAC" modified="2015-04-29" version="1">MADLYPDLKDRPLKETICLFDVDNTLTPARLPISPEMRQALAKLRHKCAIGYVGGSNFPKQQEQIGTDTLSVKDVFDFCFAENGLEAYRLGQPLQSTSFIQWIGEEKYQKLARWILKYISELEGLPAMRGTFIEFRNGMINVSPVGRNASTAERNEFEAWDKKTGCRPKMIEALKKAFPDLAVTYSIGGQISFDVFPTGWDKTYCLRHVEAEADASKGLSGIDYKTIHFFGDKCFEGGNDWEIYTDPRTIGHSVENPADTLKQLKELFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGZ4</accession>
    <name>A0A0D2BGZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238111.1">
        <property type="nucleotide sequence ID" value="XM_016379434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGZ4"/>
    <dbReference type="STRING" id="91928.A0A0D2BGZ4"/>
    <dbReference type="GeneID" id="27332173"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05090"/>
    <dbReference type="HOGENOM" id="CLU_023927_0_0_1"/>
    <dbReference type="OrthoDB" id="4117114at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF76">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="457"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="717" mass="75717" checksum="70A36D8B949A316A" modified="2015-04-29" version="1">MSSTARHHRSRGSGADEATVNGVDISHGYTNHVTTATRALRALGSSGHAMVEHNEHANEAEQSASLPSPESDSPMHEAEPESPSFRPDSPTVDAMDTDTIEVSHSSHDVNGASTNGTDPDGSDAPTAPGSAAPKRKRNFSNRTKTGCMTCRERKKKCDEEKPVCRNCRRGGFRCKGYKDELLNLTTWARRARSQGSQQSGYGEPPVSGPAPVPAPGSVSGPASGPASGPAPGPAPGPASGPASGPASGSASGSVPGSAPGSASGLAPGQPIHNGHAPVDQPNSDGAPIDNNGGRMLPAQSSQVTNVLQPQIMSAPLAIHAVNVPQPHIVTVAQPPHGQGVTHVHAEAGSQPYYGGPPPWVPSPHPPSRHGEPLPRLPELSQPEYPPPVYTQAPREAPLPASQGMYPGPSSVSPLQYQQGRPESVTLAPSGTIPPPPPPPPLTPQLNASQLQDRQFRHFDPHRGPRTDVRTSRPQRPSETTTHTRTPSDSQRMPSDSQRIPPRTFGKEDVERSKMTRSSPFKHYDQTLKNERARCKRALARYNTACDIDAGLNAEVLRELLMMVIDPNKDTSYGIPSPIPISGQLKADVVVEAPFKCSYGYNLKIDQDVFIGENCKIDDSAEVDIGPRTHIGCDVVIFTTTVLTDLVDRVGCKSESIAHPVRIGPSVTIGRGAVIHPGVTLGYACTIGAYAVVTESVDEFGEVKAGAIHNGPTVHVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHC7</accession>
    <name>A0A0D2BHC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02671</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238599.1">
        <property type="nucleotide sequence ID" value="XM_016377029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHC7"/>
    <dbReference type="GeneID" id="27329754"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02671"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF53">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="552" mass="61449" checksum="56C6223828775F69" modified="2015-04-29" version="1">METEKVVPTERELRNFQLSNPDTISLIRRAQDSDAADRKLTLLQAVKKYKKAVFWSCLLSTALVMEGYDIVIINSFFGQSQFKERFGTVNPATGQKIITAPWQSGLANSALVGELAGLVANAFAQDRFGCRPTYLFFMAWLCCAIFISVFAPSLPVLAFGEAMSGISWGVFQTLTTAYACEIVPTVLRSYVTAYVCLSWGCGILLSSGVLRAVTGLEGNLGWRLPFCLQWIWPVPLFIGAFFAPESPWNAVRRGEYDLARNSLLRLRSASPTKEQEVDATLAYIRHTTELERADTEKASFFECFKSTNLRRTEINCMTWMSQIWDGNPLTSYAVVFLEAAGFDEVQTFDINISISACFVIGVLICYAIFPFFGRKTIYLSGLSAMFCILVTIGGLGFNHTHSSQLAIGILLVICTLVNTICMGPTCYPIVAETPSGRLRYKTIAIGRFAYNVASVIQNTITPRMLSSTSWNWGAKSGLFYAGTNMLCIIWCYFRLPETKDRSFGEIDLLFENKVPARKFKSTKVDQFAHGAIYEAKAEEAGQETSMHVDKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHI6</accession>
    <name>A0A0D2BHI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_02347</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238276.1">
        <property type="nucleotide sequence ID" value="XM_016376706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHI6"/>
    <dbReference type="STRING" id="91928.A0A0D2BHI6"/>
    <dbReference type="GeneID" id="27329430"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02347"/>
    <dbReference type="HOGENOM" id="CLU_009301_6_1_1"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW18060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="530" mass="56721" checksum="B7767B4F5AAF9B5D" modified="2015-04-29" version="1">MVLSDLGRRINAAVSNLNREANLDEKAFDAMIKEICSALLAADVNVRLVKNLRKSIQSTVNFKDLPPHTSANNKKRLIQQAVFDHLVQLVDPHAEPYKPKKGKSNVIMFVGLQGAGKTTTCTKLARYYAQRGFRSCLVCADTFRAGAYDQLKQNATKAKIPYYGSLTQTDPAVVAAEGVARFKKEKFEIIIVDTSGRHKQEADLFAEMVQVQNAIKPDQTIMVLDGTIGQAAEAQSSAFKQTADFGAIIITKTDGGAAGGGAISAVAASNTPIIFLGTGEHMMDLERFAPKPFIQKLLGYGDITGLIEQISTITKESAGLKETQKHLAEGIFTMRDMKEQIQNILKMGPMSKVASMIPGLSSMMGGMSDEDGQEKIRRMIYIFDSMTAKELDSDGKILISQPTRITRIACGSGTSVRDVEELLTQHKVMASLAKNMGAQRKNMAKAQAMLQGGNKQQQMAAMQKRAQAMGMGRSMPGGNDMGKLMQMMQSMGMGGGGPPGGMGGMDLNSMASMLGGGGGGGGGGGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHY4</accession>
    <name>A0A0D2BHY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-xylulose reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238471.1">
        <property type="nucleotide sequence ID" value="XM_016376901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHY4"/>
    <dbReference type="STRING" id="91928.A0A0D2BHY4"/>
    <dbReference type="GeneID" id="27329626"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02543"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:mannitol metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
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        <property type="entry name" value="SDR_fam"/>
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    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GDHRDH"/>
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        <property type="entry name" value="SDRFAMILY"/>
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    <keyword evidence="2" id="KW-0521">NADP</keyword>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KIW18255.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31029" checksum="ED43A75E58221880" modified="2015-04-29" version="1">MDSPLNGGNFKHYNTEAPKSNLVLPLFSLKGKTAIISGAGAGIGLAVARGYAEAGANVAIWYHSNKKALERAAEIEKEFGVKCKAYQVDVRDAKAVDEAIVSQVKEFNNRLDIFVANAGIPWTQGAMIGGDLQHYQNVVKIDIDGVFYCARTAGRIWREQKENKLENFNYGKFIATASMSGHIANIPQLQAAYNASKSAVRHLCQSLAIEWVQFARANSISPGYIATEISNFVPPETKDLWRDKIPMGREGEPIELVGAYLYLASDASSYTTGTDILVDGGYCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BII8</accession>
    <name>A0A0D2BII8_9EURO</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KIW18405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016377051.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
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        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
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        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
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            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KIW18405.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="631" mass="66916" checksum="5BAB280F462DA02D" modified="2015-04-29" version="1">MKETLRKKSTRSDSNSDFDTTSEAPSNPWASESSSAANGESISRQTSKSFKTPDTGSPIRPTAQEKSASPPPPRSTTPATLEVNGAENGTDKPTRRRKTITKTPHTFELEVDLNPMKKEPPPPPLLPAAPELPKTEAAASTPAPKKKKKVSQGPPPETPKSITVNAVPSIQSTPATPTSPKPVSVPPSQTSTPTSVAQHGPISPKQTLPTPAAHPFTATHRPKKSLSSSTAVTASSNPCRFTPPLLPDESFYGKVIVLTNGASQTGQALIRQFHAAGSRVIFGDKSSDQARKLISSLPPPHVVHFNKCDMTRYSDILELFKLATTMYGRVDHAIFGVGDDGGQARSVAEAERGWFDHDRPGVNKTFRMAVSEIEREPYGLGETLTAATRFARIAMAYLKYSPKAKPKSKPVNPYASPRPDDSAGGEGGGGGQAAKNDRSLTFVTSVAAFKETSGLPIYQIAQHGILGLVRSLRSAVDPDPERDGVRINAVVTNIMVPRALAQSGGRMSVQLPPDRPEDVARVVAGVVATSSANAAITTDGTDTGITTGGGIWYEKGFERGVRERYLHGRIIYGVGTECWDVQEGLDRSETLWMGAKPVEAMMKATGTTDVGQADGGGASGGSSSSWILDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKG4</accession>
    <name>A0A0D2BKG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239634.1">
        <property type="nucleotide sequence ID" value="XM_016378064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKG4"/>
    <dbReference type="STRING" id="91928.A0A0D2BKG4"/>
    <dbReference type="GeneID" id="27330796"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03713"/>
    <dbReference type="HOGENOM" id="CLU_006329_5_2_1"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="733" mass="82364" checksum="B271C7EF888DB446" modified="2015-04-29" version="1">MTDSSKANLHDQTEPPKSLSASQSAVARTRTACKHCNARRVKCDVMQQKPCWQCRTRNVPCELISSKRGKYVRGSNPKDKTDSASSRTSNVKKTQYTARSTDNHTVTTTTTTTTTNEKETPGQVDGPEMLFARMTEPELLAQNANSVPDHARMLFFGEALPMGFIINTICSLDGRRPIVRLHHPIPAKVGEFPISHLNQDDIERLRAVGALDLPEKEIRDELIRNFFKYIYPGFPVLDRTGFAAQYQKGQASLLLLQTLLFLATTVCDESVLARAGLPDRLRARQTFYKRAKALYDADYEQDQVTLTSVLFLLSFWWACPEDQKDSWFWLGAAISLAQGLGLHRTTALSNLSSKRRSLWRRIWWSIYTRDRHIASSLGRPSRIRDEDCDVKMLTEEDFRDQHPSSIQAELVGTQEAYHVSYFVELVRLAFLLGRVLSIGYTPGRAWDDEASKLLAADFQQWQCALPLDMFQRPFKESTEPGFWACMLHLSYHNALILFCRPPTIESVTRQDSEREITVRSSTDAVTRLAEDLLSSGTLRYAQVHIIPTLFGALSIHSLVIRCRQPVSSQLAENRARQCMLALSELSKLWPAAGWILRVFDKVLRRLTGRDRCFECSPPGGKPYCSRPQSSGPIARLPDQATLRSGESTSDIASNGLDSLLSPTLHSLRASMGATESQTVDSHGGIMPEACWAEELDFDAFENIFQDSLTDAFAPYGYWAGLACHQPVSDSTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL19</accession>
    <name>A0A0D2BL19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232140.1">
        <property type="nucleotide sequence ID" value="XM_016383517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL19"/>
    <dbReference type="STRING" id="91928.A0A0D2BL19"/>
    <dbReference type="GeneID" id="27336280"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09197"/>
    <dbReference type="HOGENOM" id="CLU_101493_1_0_1"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="184" mass="19333" checksum="512CFB8136AC2228" modified="2015-04-29" version="1">MNPHQKNKIDISKLSPDEQRLFRLYGKLPNKSDLLQNKLKERKYFDSGDYALSKAGKASDTGVTTIGTEHPKAEEIPHTSPLMHTLSRNDSVSGAAGAAALASSPDGQPMLPGHAGMHRGSITGIPGGGLPGATGRSPVKESSFLARSASIDEANVDGSARADNVSLEGSVSPPAKREGIPIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLI0</accession>
    <name>A0A0D2BLI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_09293</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232235.1">
        <property type="nucleotide sequence ID" value="XM_016383612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLI0"/>
    <dbReference type="STRING" id="91928.A0A0D2BLI0"/>
    <dbReference type="GeneID" id="27336376"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09293"/>
    <dbReference type="HOGENOM" id="CLU_050424_1_1_1"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW12019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="380" mass="42164" checksum="3680C838D5FB1F87" modified="2015-04-29" version="1">MGFGAFDTVCEQSPLPLCYLLGPPTDFTAAHNPALLPECSARSIELGNTIIFQAATDFAHIAALSMTAIMIFHVRSKFTAVGRKEILTFFYIYSLLTIVSLVLDAGVIEATNQSAFPWFVAVQNGLASALCTSLLINGFVGFQLYEDGTTLSVWLLRLGSLIMFIISFAVSLLTFKGWAGLSPTNTTGLFIVLYIINAICLAVYFVMQIILVANTLQDRWPLGDLAFGAFFFIIGQVILYVFGKKICEGVSHYLDGLFFATVCNLLGVMMVYKYWDSITKEDLEFSVGTKQGNWDVKEGLLEPSASEDFRTSVYGFGRESVYDSPSMEYPPQHPTQFPSTRNSGYGNLIEARHSYGDIRKQLGNYEDYDAMRARDGEYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLQ9</accession>
    <name>A0A0D2BLQ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232325.1">
        <property type="nucleotide sequence ID" value="XM_016383702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLQ9"/>
    <dbReference type="STRING" id="91928.A0A0D2BLQ9"/>
    <dbReference type="GeneID" id="27336466"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09383"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59771" checksum="F177FEF22DFC5041" modified="2015-04-29" version="1">MLSSTTLLCVLGLVALAFYKVILEPLTLSPLSKISGPKLWALTSIRLSLEDWKGTRTVTIGKLHEKYGTVVRIGPREVSFNSTSAVRSIYGAGSGFERPPFYYGIFDVYGTANLFSFRGVRPHSERKRLLAQAFSKGAILKGHAAEMIERNVTNYLRLIESHGGHSVETFTTLHYFSLDTISHFIFGSDFGGTSCLTGNKEHQGLLDDIFDPARRRLIWCAMNFPKVTTWLYSRTKTTERLLAPFLPMKKPSTFTGVRVYAFNSWKRFHAASAESKLSPTTTRSIMGLLWKRHESVKGSDGLSDMDIASECADEFLAGVDTTSDSAMFLIWALSKPENKRFQERLAQEVLSIPPEALDHDGVPRVEVVDKLPFLDAVIKETLRMYAPIPASEPRTSPVDTVIDGYKIPAGTIVGVAPYYLHYRSDIFPDPRKFNPERWLLENDKVSDDQMAEMKRAYWPFASGARMCIGMHLALAEITTLVAAVYREYATTIPTQFLDATPGITSRFELFHDELQSRVLEHTSYIDFTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLS5</accession>
    <name>A0A0D2BLS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_00473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240114.1">
        <property type="nucleotide sequence ID" value="XM_016374838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLS5"/>
    <dbReference type="STRING" id="91928.A0A0D2BLS5"/>
    <dbReference type="GeneID" id="27327556"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00473"/>
    <dbReference type="HOGENOM" id="CLU_008681_1_1_1"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001493">
        <property type="entry name" value="Mitochondrial ATPase (Afg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="61386" checksum="9A3563BBEA58D8A9" modified="2015-04-29" version="1">MYGLSEDFAASRRGLCSLGPGPVRRYSNSGQAIQSPSPHSFRKRHLATVAEASQRGPLEEYDERVQTKRLRDDEHQRSLIEHLQDLHDTLRDYKPPQVVHPEVDDLQPAKKSLFGSLFGAAKKKKAIGEIPEDLPKGLYMYGDVGSGKTMLMDLFYETLPPNITSKLRIHFHNFMQDVHKRLHKVRMQYGNDFDAVPFVAADLAETAQVLCFDEFQCTDVADAMILRRLLESLMSHGVVLVTTSNRHPDDLYKNGIQRQSFIPCINLLKNKLKVINLDSQTDYRKLPRPPSGVYHHPLDRAAVSHAKKWFNFLGDPENDPPHPASITVWGREVEIPEVSGRAAKFTFHQLIGRATGAADYIEMMRSFDAFIVTDVPGMTHRERDWARRFITFIDAVYESHAKLVLTTAVPLSQLFLSKTELDESLESVTKKVDKDDKSVDKHDKKVAAQAKASDTEGEGADVDDVMRNLMDDLGLSMSMLKQSSLFSGDEERFAFARALSRLSEMGSQEWVERGMGLEKRGGLNEKESWQRVRSRWREDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLS8</accession>
    <name>A0A0D2BLS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_00478</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240119.1">
        <property type="nucleotide sequence ID" value="XM_016374843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLS8"/>
    <dbReference type="STRING" id="91928.A0A0D2BLS8"/>
    <dbReference type="GeneID" id="27327561"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00478"/>
    <dbReference type="HOGENOM" id="CLU_007676_0_0_1"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="874"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="931"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="16">
        <location>
            <begin position="449"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="991"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="997"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW19903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1010" mass="111397" checksum="642A90F3503ACC07" modified="2015-04-29" version="1">MARLGRGGFLSLAVIFHLVYIYSIFDIYFTSPIVHGMKPYKVELDRAPAKRLVLFVGDGLRADKAFQSFPDPNPPDPGNADLTPRPLAPFLRSRVLEHGTFGVSHTRVPTESRPGHVALIAGLYEDVSAVTTGWKLNPVDFDSVFNRSRHTWSWGSPDILPMFKEGAVPGRVDADHYPEDFEDFTSDSVALDIWVFDKVKELFQSASTNSTLDAMLRDDKLVFFLHLLGLDTAGHGFRPYSKEYLNNIKVVDKGVEDVTKLIDSFYGDGETAYVFTADHGMSDWGSHGDGHPDNTRTPLIVWGAGAAKPEIYRQVKAPGHEDGFSFDWGLDHVRRHDVDQADVAALMAYLVGVEFPVNSVGRLPLNYLAASPREKAVAAIVNAKQLLEIYHVKEEQKRATSLNYQPYSAFASANTTIESQISLIESLIGQGQYEDAVKMSSDLFNDGLQGLRYLQTYDWLFLRALITLGYLGWIAYAATTVIDIHVLHGAISDDRTTGTTIAFSSILVLLYSFFVVERSPVTYYAYALFPVFFWEEVFARRKAFMSGFQILFDHIQGVSAYTILSVQGVAYLLVVEGLVQSYFHRPLLSVCYVFGAVFPAFYGIEFMRKNRGLVLSWAAGCLVMSTFTLLPAIKVEDVNTITAGGLLMLGAGLAYLYYEHDIHSQSKSGQPASEPNTVSRMLMGLQLGVILLAIIVTRSSVSSIQAKNGLPLGNQVVGWIALISSLILPFVHRIAPNRHYLHRLVIIFLTFSPSFIILTISYEGLFYFAFCSTLLAWVRLEHAIQVHGGPKSGSVTAPLANGVTITSTTSSQSANLRPEETFRTLVLTDLRRALFFLFFLQSGFFSTGNIASISSFSLDAVNRLVPVFDPFSQGALLLFKIMVPFSIISAALGILNRRLGLQSSALFMVVMALSDLMTLNFFWMVRDEGSWLEIGTTISHFVIGSLMCVFVAGLEGVSHALISGVEVDGFEDTVRANGGVEVVAGKDKSNGGVNGSLKEHEVADERPVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM07</accession>
    <name>A0A0D2BM07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_09500</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232440.1">
        <property type="nucleotide sequence ID" value="XM_016383817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM07"/>
    <dbReference type="STRING" id="91928.A0A0D2BM07"/>
    <dbReference type="GeneID" id="27336583"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09500"/>
    <dbReference type="HOGENOM" id="CLU_022880_1_0_1"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="15">
        <location>
            <begin position="386"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW12224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="609" mass="66821" checksum="DB419944D3BA5960" modified="2015-04-29" version="1">MPLSKRPPPYVEAEDPKRPPLRSSQTEDLNHHSIPGDEISVDEQAAVLQAMSLESPPGIVQSPSSYSPTSTEFSPISPIIASAPTTPLTPATPTSATSSKFKSVLQDVRYFAGGLIAHPYESTKHYSILRHSHGLVYYSGSTTNLAITIFSDRELPPDRTLWLQRKGFSGKTGLKIGGLLGARSTWINVTPTVKATPEQLNPTDERAWQRDIKKFLKKAPKEIRSHRVRETDVLRIPCEADDGYLRVVLCTAEGKKVLCGSPIFRLASSTTEFSTLRGASIKTMPLEMGIKIGQIVGNNILSATLTPIADQAKSAVTGQVSRIYQPGLAVQEAATLAYDNSGVQDKIDNVNEQYDTARENAYSSVQEETYDALQRPDIVGPDTGPVAPFPVRFHGKVVTGTGRSRSMLNIPTANLSGVPEDILARYKGVFFGWAAVSLPKKLAAETAVPSDWFKAVIFISPDPDRTRTVVHKNSARVYVLHDFQGVQLVDAKVSVMLMGYLRAMQDLNPYEEPDVESMQFDTYKDIAVTTASLNRPAWTAEATLERVKSAASSRTMSERYVDFRQNTQRQMDRVPVNKLGIRTEGAALKDKLIGVGGVWVPREALSYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM12</accession>
    <name>A0A0D2BM12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_09505</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232445.1">
        <property type="nucleotide sequence ID" value="XM_016383822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM12"/>
    <dbReference type="STRING" id="91928.A0A0D2BM12"/>
    <dbReference type="GeneID" id="27336588"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09505"/>
    <dbReference type="HOGENOM" id="CLU_013160_1_0_1"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20085">
        <property type="entry name" value="XPF_nuclease_Mms4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000004">
        <property type="entry name" value="Crossover junction endonuclease EME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047521">
        <property type="entry name" value="XPF_nuclease_EME1_ascomycetes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="303"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="192"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="245"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW12229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="659" mass="72542" checksum="3CC038E22F9EA7CA" modified="2015-04-29" version="1">MAEVINLLSSSSPPPAPLRSDSACNPVAATVLTQIFEDVDDFDDTGSIDFAIDRPSKKQRLTPELPKILTQGSKPSALGERTVQPVYELSSETSSVPELKFDANGELKSRPSGLCRTEAVDEILFTSSLPEGEHSANLKLSKPRPFEVFEDILDESCDIDVNVSRSGPTDDTQRQYSHRTANLLAVLSQEPVAGGRHRHHRSQTTALATMRSANTRSLPVDDIENSSSPAEAATKNVAKGSNKVDPAKAAERAAAKASRDAEKEAERERKKLERELRAQEKQKAADLAEANKSRTNKKDAVPEMIVDMASSLQGTSVGNQVDEYMKNLGAEVTYSDPELDLSDKAPEQMQYGNIITWRRKVKSAYNDEEGRWEPLSTSRVVPEQHVLIHLTAVELAAMLCIPKSAVTAEPIDEASMKSNLDKHVASIRHRFGSCVPIYLIEGLSGWLKKNANAKNRAYTAAVRSQMADADQFEAGNMRATQARHRKRKKPPTNTLDLSSVTPEVAEEVLLHLQLAHQPILIHHTTSPGTTASQISALTQHLATRPYRQAQLDFNLKSATFCMDGGQVRTGDDPRDTFVKMLQEIQRVTPSMAYGIVDKFGSVRKLVQGFDRHGNLLLEDVRKSVNKDGGWSDKRLGPMVSKRLFKVFMGRDPSATDGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMQ5</accession>
    <name>A0A0D2BMQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240439.1">
        <property type="nucleotide sequence ID" value="XM_016375163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMQ5"/>
    <dbReference type="STRING" id="91928.A0A0D2BMQ5"/>
    <dbReference type="GeneID" id="27327881"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00798"/>
    <dbReference type="HOGENOM" id="CLU_017779_3_0_1"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF116">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="117"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW20223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="542" mass="58427" checksum="25A7CB98A1F1D848" modified="2015-04-29" version="1">MSGQLPSETKRASGILFVIYEGTIDLYVAVAAGLALVGAGLAISTVGYFLSSESASTSSTQSLEATPTIQHNVSPANISEACREFRRIVGKANVSTATADLISHSGSDYQSYAWTEATATPGEVVVYPASTQEVSEVVKVCHRRRIPITPYSGGTSIEGQYIPSMGGICIDFTRMDQILEINPLDLDCVVQPGLGWQDLNHQLESQGLFFPPDPGPGAMIGGMVGTGCSGTNAAAYGTMKDWVLSLTAVLADGTIVKTRQRPRKSSAGYDLTRTIVGSEGTLALVTEATLRLAVKPRFESVAVCTFPSVKEAARAVESIIGRGIQVAAVEILDEVQMRSINEAGLTKRKWKEEPSLFFRFAGITDSIVQETAKLVGEIAQGHGSTSYVFATDQEEREELWSARKNALWSMMALRQHPTDKVWTTDVAVPISRLSDIIEATKSDIQANGLLGSIVGHVGDGNFHSLLLFPEEKRDVAEAVVHRMVDKAIQMEGTATGEHGVGLVKRDYLEKELGRSTVDLMRKMKSALDPLCILNCDKIVRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMR7</accession>
    <name>A0A0D2BMR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptide hydrolase</fullName>
            <ecNumber evidence="11">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_00813</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="11"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240454.1">
        <property type="nucleotide sequence ID" value="XM_016375178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMR7"/>
    <dbReference type="STRING" id="91928.A0A0D2BMR7"/>
    <dbReference type="GeneID" id="27327896"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00813"/>
    <dbReference type="HOGENOM" id="CLU_025866_0_0_1"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112863" description="Peptide hydrolase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="12">
        <location>
            <begin position="172"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW20238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="389" mass="43451" checksum="446C376E5B2CFB95" modified="2015-04-29" version="1">MKCPSLLAFAATCATVVAFAVDLEKVFLDDKRPVAQETFLIESSPGETKWVTEEEKWELKRNGMRFMDITENGHTYPYVAFSERDSSRVTYPSKTQYNETVKALATALDKDNMHKHLKGLTSFHTRYYRSPYGVDAAKWLYKQIDSTISDSGAFDHGATLDKFDHPWGQFSIIARIPGKSNHTIVIGAHLDSINLWLPSVFAAPGADDDGSGTVTILEALTALLQSDDIVRGKAENTIEFHWYSAEEGGLLGSQAIFKSYHNSQKSIKAMLQQDMTGYVKETLAHGKPESVGVITDFVDPDLTEFVKEIITVYCDIPYTLTKCGYACSDHASASKYGYPSAFVIESDFEYSDNKIHTTDDVIEHLSFDHMLQHAKMTLGFAYEAAFAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNL3</accession>
    <name>A0A0D2BNL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240336.1">
        <property type="nucleotide sequence ID" value="XM_016375060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNL3"/>
    <dbReference type="STRING" id="91928.A0A0D2BNL3"/>
    <dbReference type="GeneID" id="27327778"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00695"/>
    <dbReference type="HOGENOM" id="CLU_084512_0_0_1"/>
    <dbReference type="OrthoDB" id="2439692at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118:SF2">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239128" description="DUF7707 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="3">
        <location>
            <begin position="21"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="206" mass="20954" checksum="F0151B093FEB42DE" modified="2015-04-29" version="1">MQFLVLATTVAAFTQLAITQTIDPNSVPLSTRQTWCNSQRAQCPLICVDQTNSAGTNSNDCDPTDLAYSCICANGLSPNASEYSLTMPYYICTQYNTDCQANCGNDNTCAAACVQNHPCGATDPTRVNTSTISTMSATSTTNGAAASTASDGGVVYTGFGGASAAATTAGGDSGSSAATRVIVNMGQLYGLGVLVAGIFAGFALML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNS1</accession>
    <name>A0A0D2BNS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240749.1">
        <property type="nucleotide sequence ID" value="XM_016375473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNS1"/>
    <dbReference type="STRING" id="91928.A0A0D2BNS1"/>
    <dbReference type="GeneID" id="27328191"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01108"/>
    <dbReference type="HOGENOM" id="CLU_278973_0_0_1"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1059" mass="119746" checksum="DE52E1F3C9FDD9D5" modified="2015-04-29" version="1">MISPSPIVPSKNALRALRRLALSPPAVVVVGAVGSLCGAAVVHCEIRRQLVLAERIIETKKVLRSLTNGPPAERLKDMFEAAERGEDVTSPEWRAKRRRKEIGRRSFSTSSRTSAPAGNDYGGTKETSMSREEERKTPSTQKPIKPRYHPIPRLYLGKHVSRSREKREPSFTEFRFSSQRTNAGPLNSNRRLLANQHYNTTSQKHINNSCFPTGSPDGNLAGPSLQHGSMRPTLREGDSDTSVERSRDKSASGLLDGEPGIHNPSAKYDSVTSLPFRPLYVLPRQSSTEGSPCSMDRECDVATKPAPAAPSTSKDLRELPRKELRWHHGRRLWSSCTTNKANTIDLDTALDTEFTSYRKRVQSYGPHWPKRTRVFESPKLETGIDELKYIPYSIRNHFTKSVNPKVYLDVQNFISPRKHVSTYEGRLQRWSAAMRYYTHQKDPNWAMAEALFFSWRFSFRPEDLICAPVMKLISYLLATAPTSERLQELFFPSSVPGDSTDHHYSLAPRYLAIFCEGHDEKSCIAELAKIHKLAKRSKLAHKDQVFVPVLRKALRNQDPGQRDDLINAVVEVYGEAVRPYILSQCALLYTSSGDWVDVQETLSQIHATGHSRQRVYQYSLVFNSILKRHLETNGAAQAFDFLLGCIKDAGLVPLRSISTTIICALVQEKRFDLVSEWVRLVREAFPRCKLGFDLEEDAWKLGQALRTIGATCQQVAEVCRGISLGCRDDPFSPVLKDFVKDIVRHDVTGKFHTLAEHRPSLVALDTYLQWVPLSQVIDVASRICTSHRPPVSGGDVFDSALQDLASQLNGIEELKSIFAGDLNLARPKSVGDYQSDASSRGISSVQDSWRSSSTAESQLLISELIERAELIDIVYIQDMVAEHYDMQQADGYAVNHLLLERLLVRLASNRPWDALKLVETFYARHYAQCLSGKGLGNGLFLKWMSLVLEIGDNHSTLEVLWAILDSSSQLEWSFEFTALVDIVGRSFTPSTTPEEPRELNYLMERIRVLKKTVREPKSVNDDFTFPPWRDWEEDLRDTINLPKVPHLAEEEEMLEARWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPI7</accession>
    <name>A0A0D2BPI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233205.1">
        <property type="nucleotide sequence ID" value="XM_016382502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPI7"/>
    <dbReference type="STRING" id="91928.A0A0D2BPI7"/>
    <dbReference type="GeneID" id="27335259"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08176"/>
    <dbReference type="HOGENOM" id="CLU_008828_1_0_1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF13">
        <property type="entry name" value="SPECIFIC TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="738" mass="82825" checksum="E29334F6CCBC4494" modified="2015-04-29" version="1">MPQSDQQKSRKRSSATAALTSDSQADIEETRTRKKRNRYTPHACNRCKAAKVRCDGRLPCSYCSTRDAETCNYSAVALPTFQTEVDTVNNESHIEQKISEVLARQNEKLDLLIKRTEMFDPVHGFSLGGQAHCGSRLLPSKRSLPLFQSATSAFCCINIIGGPINTHHSNSHDNAAYLSSVPLVPRSSFSIIRGRIVEGETSDLDSRDDASDAPNPLLQADDHIHYSNFASFHPLDELEDSQMSQMLNEFEAMIACTYPIHDIADLKQKMGNYLRSRQSSPTKGLADADVTMLEENDITMLKLVMAICLLGQGHEHKDLASRLFQSTQADVQAKVWDAMVDLKDLGLLILVVFYHLHRGSWRLGWRFLGNISRVVYELGLNREIVLARLFPEWENRRRALNTVWTVYVLEQHLTYALGHPNVMQGLHIESSFPRPINAPFLSAMIEYSQIGREACSALLNDTAVVGGNCNIWQSSYTSFQYRIERWALETMTKIQDPLAYNTTDPSRRYMATLIRLRANLIRILVARVFICTELRMSAPSEIWSRSVHTAADTVQVLSGLDRSSKEYRFHRPQLNHFLISALDLLLFVCSSAHSDYEKSPEISISSDTSTTARQAAMVALNVLRDLAEVCDHSKSLWEKTKAIASRINLTSWLFEHGSIIRNGQQHLQTEPQSAPGGLRDDSLFTSELEDPSRQNTVDQPSSAVDDFTSILNDLTSEAAFDSLQTSFNIPGDFWAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPN6</accession>
    <name>A0A0D2BPN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241139.1">
        <property type="nucleotide sequence ID" value="XM_016375863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPN6"/>
    <dbReference type="GeneID" id="27328585"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01502"/>
    <dbReference type="HOGENOM" id="CLU_1578546_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="169" mass="19980" checksum="2BFAB95AFBFE18D6" modified="2015-04-29" version="1">MSQRGDETPRARDYELFGADEDFSSLGSIRDEPTYKAHRTFDGNKKHPEKHTTESLRRRPSLKHLYAPRDATTPMWMDEKLGYTHRRSQFSDPSRRDSGEWHQENVSEDNWQAVAEARSSGVVARDFAYQKNEFEHNDGRSYPGRMTTRERFEMNPKWPTAEDMKKFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ66</accession>
    <name>A0A0D2BQ66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_01657</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241294.1">
        <property type="nucleotide sequence ID" value="XM_016376018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ66"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ66"/>
    <dbReference type="GeneID" id="27328740"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01657"/>
    <dbReference type="HOGENOM" id="CLU_011815_2_0_1"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="19">
        <location>
            <begin position="236"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="84"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="17">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW21078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="554" mass="62901" checksum="88BADFE9C620A35C" modified="2015-04-29" version="1">MAGGDHGGESNGTPEPVIKGFATLNQLQIGVKAFVEKNGEPRKAEILSIKQRNGSLKFYVHYVEFNKRLDEWISAERIDLSQEVEWPAPEKPEKKKTTVTTKTSSTKNTQAKSITTTNKAGRPRTDSRPGSATPDLLTSKAGNDRKRPIPSKAGGKENRDDSSLLADDPALAQAGTPLPSLSQEDSTELLPTGVTDVEMTDVTKTEEKVPTILEPEEEIEKLRTGGSMVQNHAQIHLVRNLEKIQMGKHVIEPWYFSPYPQEFADVDMVYIDEFCLSYFSSRKAFERHRSKCELRHPPGNEIYRDDFVSFFEVDGRRQRTWCRNMCLLSKLFLDHKTLYYDVDPFLFYCMVTRDEHGCHLVGYFSKEKESAEGYNLACILTLPQYQRQGLGRLLIAFSYELSKREGKLGSPEKPLSDLGLLGYRQYWKEVLVELLSDPARLPPPGSASHTPSSEHLHPHSSLAFGAPSSQFSTSIAEIASLTSMTEKDVHEQLEVLKLLRYHKGAWIIVVRDELLEWQEKRREKEKVKGTKRIDASRLNWKPPVFTASSRTWNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQD5</accession>
    <name>A0A0D2BQD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241389.1">
        <property type="nucleotide sequence ID" value="XM_016376113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQD5"/>
    <dbReference type="GeneID" id="27328836"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01753"/>
    <dbReference type="HOGENOM" id="CLU_2527474_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="84" mass="9011" checksum="11F2D39945F744C5" modified="2015-04-29" version="1">MSPVHGKGKGKSQSWSNERDVIESPSPSFPPRTKKRPGLSGANDPTATKSDSALVKSKKNNRESLTASGHGQRRVASTPAYLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQQ7</accession>
    <name>A0A0D2BQQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241549.1">
        <property type="nucleotide sequence ID" value="XM_016376273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQQ7"/>
    <dbReference type="STRING" id="91928.A0A0D2BQQ7"/>
    <dbReference type="GeneID" id="27328996"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01913"/>
    <dbReference type="HOGENOM" id="CLU_016895_1_1_1"/>
    <dbReference type="OrthoDB" id="4152393at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57379" checksum="E0EA9B4B021D366F" modified="2015-04-29" version="1">MVKLFFVESSPTARSRKDTAAQQAKIRSHAAIAGHHSKARLRTQISEPSSSINSPSSPASSFDGASIITAPSPASSIGIDFGVSKFSIKSRSYGDSEEESSDSSPGSKFYTTSPTPTSSSLLLGAGPCFHGTRTDPFNCISTDHPHLLAASVDYFSGVTVPAHSALYELFDITNIYNGYWFELMSDPDFAYSGVCLTLRVRELSCDSNAKPSEEVLLALGIALSRLRKRIANTGNVVDDISVTAVSFMAAIAKAIGDSSTHQKHKQALKYMVKARGGLDKLGHDGMDKCLLLQREGFWSIADGSTIFGDERENIVSIYPKMPLSGVNLEMTMSIPLGFRDLAHLGKLSVQVLEVLVRTQQKAQMEKTLGSAQRLPELFKTHKRRYSDFHEACPCLSEPDVDGGASIEKLSVLAVIIYCSTIFTPTRSTTVLYDTCRKRLQSDIATIKPDSAAEAVCLTWVAAMLVWSWTTVSGQLTQHGISCLAKLKTTILRDIEWTELESILGNFFWSEKMSKSLEVHYLALDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR71</accession>
    <name>A0A0D2BR71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233960.1">
        <property type="nucleotide sequence ID" value="XM_016383257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR71"/>
    <dbReference type="GeneID" id="27336018"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08935"/>
    <dbReference type="HOGENOM" id="CLU_036623_1_0_1"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="110"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="437" mass="47316" checksum="A693D3EDEBE5DE32" modified="2015-04-29" version="1">MADSMNLISAQISFLEPQLALVHIPIELYSFCLQPILRLLFGEDHDEDAAKISWTNRHDFLNVSITPVECSIICSRYLAETYVAPVAQVLNQLYAANSSGKDSRTEIQISSEDYVAIQVDGQGLDAGQRVLELTSPLAMAGISIFFITTYFSDYILVPLRSRKTVTKALQQRGFVFSQSVDAFVSQLSPTSPTVGQSGHPLYSPSLHDISAPTTPPAKDIPELQIRTFTKLRKNNISPLVDSQVRLVSCAGSREFDHERDAQLRNDLLQVLIATVPVADDTRKARPLNNGANLSSGAALAPDLSFGAKFLSLTITAGEPISVLMEQRLLERLGQSLLGAKSEDDALIPITLDLRDLPLDATGIVCGVAGRLAQGSADEQEQPDFSPVSASGQDPHMPVEISFLSTVRAGTVIVRASHLDKAIDALKYGMEKVAEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRW1</accession>
    <name>A0A0D2BRW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translation initiation factor eIF4E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241366.1">
        <property type="nucleotide sequence ID" value="XM_016376090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRW1"/>
    <dbReference type="STRING" id="91928.A0A0D2BRW1"/>
    <dbReference type="GeneID" id="27328813"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01730"/>
    <dbReference type="HOGENOM" id="CLU_043552_5_2_1"/>
    <dbReference type="OrthoDB" id="17977at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20564" checksum="C998DF73F4DC1E89" modified="2015-04-29" version="1">MGSVYPTTTGTALLSPRRSPVPPAAPNTPSEKRGEATISSPPSLPRRSSSLHKQLITKLRPLPLQYHWAVWHSKPDPQHQYILTPLVDDVSDIGRFYRIFNNMPWLQIRQNDSIHIFRAGVKPLWEDAENQQGGRWLIRVRPDNNRAIRVWEEICLLCCGGELQAAIAQGKHKPPSALVLATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSG3</accession>
    <name>A0A0D2BSG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_06970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234405.1">
        <property type="nucleotide sequence ID" value="XM_016381303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSG3"/>
    <dbReference type="STRING" id="91928.A0A0D2BSG3"/>
    <dbReference type="GeneID" id="27334053"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06970"/>
    <dbReference type="HOGENOM" id="CLU_059493_0_0_1"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.450:FF:000001">
        <property type="entry name" value="SDT1p Pyrimidine nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="248" mass="28430" checksum="2F57C5783EDC6304" modified="2015-04-29" version="1">MGSIASDPGSKDERAIFFFDIDNCLYPKSKKVHDHMAVLINKYFVTHLNMPTEEATRLHQQYYKDYGLAIEGLSRHHQVDPLEFNREVDDALPLDDLLTPDAGTRAILESFDKTKVKMWLFTNAHITHGRRVVKLLGIEDLFEGITYCDYSQTPLAPKPLPEMFEKALREAGASKDTEIYFVDDSFLNCRAAYERGWLNTVHFVEPSVPDPPQKASQHQISHLRELLGLFPEIVKDTKQVLKDPKELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSH0</accession>
    <name>A0A0D2BSH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241591.1">
        <property type="nucleotide sequence ID" value="XM_016376315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSH0"/>
    <dbReference type="STRING" id="91928.A0A0D2BSH0"/>
    <dbReference type="GeneID" id="27329038"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01955"/>
    <dbReference type="HOGENOM" id="CLU_000315_2_7_1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="167"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="591"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="84837" checksum="D920E2B7C6466DF4" modified="2015-04-29" version="1">MKDTKGKKVGQHDLQYLMNAIIFGPEEFCDGVGTYLAKCKKYLQDPVQCNRDVPYCNPHLLSRQQELVMTSSLVIKTSESSMQEVVNVDAPQDLFSRLCDDDHLQLTETPDLLRTPLYKHQKKALTFMKQREMPWSYEESPDTMWVRDEEPANSGRYTNLVTGNSQRTEPRESKGGLLADQMGLGKSLTMISLIASNPAQLTSSLTFTANGTIRRIKSTLIVVPYSLLDTWDTQLQRHLKPNSLTWYRFHSSQKRKLLALGGYDIVIATYETLMGQQKKHNDPAYTDTTLFSFAWHRIVLDEGKLKQPSLQIIHGLTQRWAITGTPIQNRPTDLGSLLEFIHLEPFTDPKVFESTVVKPWLKSDDKDTSRLKKLIRYVSLCRSKTIIDLPPRRDVIKYIDLGPEERDLYESAKNRTIQKLDEALSVNPSTPGMYLNALEWLNELRLLCNHGLMQCSQKELQKLTGPLSESASVATISQGETWYKSTAKKAFATLVNSGSAVCKLCQTNMAAGTGEADGFEHTKPSLSKCLTVICGSCIQNRPNGGRVAGCGCNPPCPKAEVSWASEISDRQPRAGLPEVEEAKVSTKLKTLLKDLEVNVKTEKSVVFSFWTYTLDLIESLLKKTLISYVRIDGSLSGTRREEAIQKFQTEDSVRIILVSITCGGTGLDLTAASRAYLLEPQWNPMIEEQALSRIHRLGQTKEVKTVRYRVRNSFEEKVAIIQDAKKDIAAGAFSSNQQVGVVNSTSRLQEFRDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BU17</accession>
    <name>A0A0D2BU17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234995.1">
        <property type="nucleotide sequence ID" value="XM_016381893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BU17"/>
    <dbReference type="STRING" id="91928.A0A0D2BU17"/>
    <dbReference type="GeneID" id="27334647"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07564"/>
    <dbReference type="HOGENOM" id="CLU_612544_0_0_1"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="18"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="440" mass="49107" checksum="09858E4B2CC8D12B" modified="2015-04-29" version="1">MTEQHLLLSQLGPTLTQEHSLALVQIFINTSLACIAHTRELIPWTSPCFRARYIEQINTVVAADARNSYSAFKALDSNATSGGQEIRILVRGAHKRADQLLELLEDGIFEALQHRYLDAFQVFVTDANDSHNVLETYSFAFEYTQDRIRSVHMSSMSPAVVLEDFQHSFKAFIRSLLRILKFLPRLPAHRRLGMSLTYNDSCPHAYHPPGFVDQAEFSGKAGGKLCDMLWKSPGDLVSELQIGHQHIAVSVHPFGAHEPSASIDPQDIAISKHLQAMQKTSSQHTTAFVSTLQESRPRRKRNIEVTHPVKRMKLHDTPRRQERGARQGPLPQKHIEVTDSLEQSVSKKDTDKTGLSPEMDHDRGLQQETTDGHGVLNACSNSESLGTTHSLRRKISISRILINIDRSSSVESESVEQPLQSSGGIDYSSDTDTTSTATDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BUH6</accession>
    <name>A0A0D2BUH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235120.1">
        <property type="nucleotide sequence ID" value="XM_016382018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BUH6"/>
    <dbReference type="GeneID" id="27334772"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07689"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF78">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="44"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="507" mass="56520" checksum="CB7F99EFE1AD5B24" modified="2015-04-29" version="1">MASEDKITDASIIGEKVETSHEEAMHFGQLTEEELHIEKKLRVKIDMLIMPLVILVYLMNYIDRNNYAAARLQGLEKDLKLVGDQYQVGLSIFFVLMQVPSNLLLNYSGRPSWYLGFFICAWGLVSALTSQVSTYGQIVACRFVLGLVEAPFFPGVLFYLSKWYTKSELSLRMAIFYSGSLISGAFGNLIAAGILSGLSGARGMAAWQWLYIIEGAITCLIGIVIIFVLPDFPDTWRALSPEMKRVANRRLAIDAAEADVDEAGGMSQVRGMKLAFADPKTYILAIAYHGITGAAGFQNFFPTLTATLGYNHIVSLLLVAPPYVFMVFYSFFHSWLSDRVGNRFWFFMYPIPVTIVGCIIFMTTDSFGPRYFSLFLLNFVFAMNGTCYAWIANAIPRPPAKRAAALAFINSVGNAASIWTPFTYFPGQGKHYPTAIGIVIGLLVLAGLSGIALRFVLERQNKQLARLEDENVQLTERELARLRKTADIEGIDVAAARRLQKGYRFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BV86</accession>
    <name>A0A0D2BV86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_05214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235385.1">
        <property type="nucleotide sequence ID" value="XM_016379558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BV86"/>
    <dbReference type="STRING" id="91928.A0A0D2BV86"/>
    <dbReference type="GeneID" id="27332297"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05214"/>
    <dbReference type="HOGENOM" id="CLU_2084864_0_0_1"/>
    <dbReference type="OrthoDB" id="3660917at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW15169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="117" mass="13410" checksum="A6D3F74526462B93" modified="2015-04-29" version="1">MKVDPQGIHYLGRDGVLRSFTADREVIDAVGLAPKHIKALLDRTPYMQEAEDIFRCVDGTKVPREKWFNPDKSDIPRTATEEEKERERIMVEEFKKEGILPGSRCCGPATMSDYRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXF3</accession>
    <name>A0A0D2BXF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial division protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_06009</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
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    </evidence>
    <sequence length="679" mass="75048" checksum="7FE72477DDDFAA7F" modified="2015-04-29" version="1">MDFDDESQPMALDRPLSPTPSRSVSVDPARLVGRFHDARSSLEEESAFEFPPSQPIPIDSIRASKSRHSISQGRPKRLSTTNKPGMPLNILPSAPASPPTPAPSPTPYQRAPSWTSAGENEDAFLRDARGHFASLNAAERERYLAELLNMCDSHLLSFVHHFVSPRLKKDPFEHLPDELCLRVLSYIDDPLSLARASQVSHRWHKLLNDDMLWKRMLDKQNWRRASSSSIDEMEPLSLPRSAHGPYSYGRSPKRSLDGSIVGPSSSAPNLTLPGSTGPSSSPRLKKRQSQSHYSHFRHKYLIEAAWRKGGHSIIKHITPDQGVVTSLHLTDKYIVVAMDNAKIHVFNTVGEHQKTLKGHVMGVWAMVPWDDILVSGGCDRDVRVWNMSTGRSIHTLRGHTSTVRCLKMSDVNTAISGSRDTTLRIWDLPTGMCKNVLVGHQASVRCLAIHGNLVVSGSYDTTARIWSISEGRCLRTLTGHFSQIYAIAFDGNRIATGSLDTSVRVWDPKTGVCTAILQGHTSLVGQLQMRGDTLVTGGSDGSVRVWSLLTNSPIHRLAAHDNSVTSLQFDDNRIVSGGSDGRVKIWNVETGQLVRELSQPAEAVWRVAFEEEKAVIMASRSGRTVMEVWSFSPPDEQYDVRRSESPMSLPEQTSSVAGDDDTLHSDHDIGDADAPMKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXZ5</accession>
    <name>A0A0D2BXZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Frm2/Hbn1"/>
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        <property type="entry name" value="Nitroreductase"/>
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    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
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        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF4">
        <property type="entry name" value="NITROREDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G03530)"/>
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    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <end position="183"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="205" mass="22796" checksum="52575B684BFA515C" modified="2015-04-29" version="1">MGAADNFLELTKARRSIYALARESTIPDSRVEEIVKHAVTWAPSTYNVQSARAVVLFGAEHEKLWAIVKKHMDQVPMDEGVKGYLAGRINGFNSSYGTVMWFEDQAALDALGEKNAMVVPLLTEFSDHSSGMHQFIAWTALEAEGLGCNLQHFNFHPGIVADVKSTWDLPETWKLKAQLVFGKPSAGPHDKTFEPIEKRVLVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BY55</accession>
    <name>A0A0D2BY55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236465.1">
        <property type="nucleotide sequence ID" value="XM_016380638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BY55"/>
    <dbReference type="GeneID" id="27333383"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06300"/>
    <dbReference type="HOGENOM" id="CLU_576221_0_0_1"/>
    <dbReference type="OrthoDB" id="4161826at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="474" mass="51889" checksum="26B0173A6CC99C57" modified="2015-04-29" version="1">MRHLLSPALRRARRASQGGDTKRSESRNSEQLDQSMSHDSSACSAVLGLSNRRSFALPSVPSSPLLLEEMFKLWPSETVSDATIQSVSGTVESKQGTSVTIVQDSGVWDQDLHPSREASSPLPELHPTRLLAQFSTPLNRPATPVPSLTFSQISTCSRSSREVTSSSPDQATRSSVVHGLCLAKTSTIGLEDNEMLDPFYTPPRTSGNRSAKLATDDFPPYEAFYVNPWTGGYAGAIAPSTQPRHVAPSAPEISYIDWDDEDAEHTHRLPTAIARIRKSLADLRTADRFTSSRKASTRTQDSSDDAVPSIPRPATADDGARDVKCCSPTKITHGTPDKTTLLFDKALPPLPNEQLTTTCPEPTDQCSRMSGRSTEAMSKRSSRSLPSSFISANERRRTIDSELEGPDPSSPVAFQHIIPRHNQSPRSVSPPKLRRRESSNCLCLRSDRLNKSASVIVMEKWLRSPFASQKGNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZ27</accession>
    <name>A0A0D2BZ27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236760.1">
        <property type="nucleotide sequence ID" value="XM_016378083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZ27"/>
    <dbReference type="STRING" id="91928.A0A0D2BZ27"/>
    <dbReference type="GeneID" id="27330815"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03732"/>
    <dbReference type="HOGENOM" id="CLU_1510627_0_0_1"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19548" checksum="6301F62D35605563" modified="2015-04-29" version="1">MPRPVTEVVTLTLQPEANADEVISGWDDISYHKAFEQSETDFAAAGAFLGPVITDPPFMFHVYLDPVERERILSAPIIEVATFFSVPKGYSDEGEKLLRILGSFQGGLGFLHAEIVEDIAVEGINPKGIGWFNFLAWESTAQHVAAKESDAVQGSIHLIRGEGQMGEIERHYVKFTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C2G5</accession>
    <name>A0A0D2C2G5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238050.1">
        <property type="nucleotide sequence ID" value="XM_016379373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C2G5"/>
    <dbReference type="GeneID" id="27332112"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05029"/>
    <dbReference type="HOGENOM" id="CLU_071627_0_0_1"/>
    <dbReference type="OrthoDB" id="2386090at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="340" mass="38318" checksum="86672AF10430BC74" modified="2015-04-29" version="1">MRGLPLVLVAEVRLAFQTCSRQHVASRRTRFSTFQPLLKKPLPRRKVEAPIQVVHSQLRAQKEASLTDRAAKENAPAKGQAASRKDLVPVQGEGRALQDGRKVEVPFKVIPRADITPNLTLSPKERLHIEQLTRNLPPRTEPKVYKKKLRIYSVGNGKIYAITFLRFAAIFALCLTTVVVAPAHWLNGSSAITVAGLWLAGFVPFAFIHWALRPMITEVFLRLPQSAQHSPKAAMAYAKSLPADAVLDLRFMRATTLSDYVSVRLDHTKPVRSHIRPVNFEWVGPFVHRGSFLRPNPTQFYVRAESARGKAAWDVTPGIWKQVYERLTGNESSSVARWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C2X7</accession>
    <name>A0A0D2C2X7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238175.1">
        <property type="nucleotide sequence ID" value="XM_016379498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C2X7"/>
    <dbReference type="STRING" id="91928.A0A0D2C2X7"/>
    <dbReference type="GeneID" id="27332237"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05154"/>
    <dbReference type="HOGENOM" id="CLU_042179_1_1_1"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="73"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="316" mass="34397" checksum="DB4649256AA92B97" modified="2015-04-29" version="1">MALIRSEAHKMRNDQFRTMFESVEAAKAFIPPTAATVKARAGALGVPHNVTVIPNGKGAKLHYLGVPNANKLILYFHGGGFALPPTEGHVTFMLQCADKIAQSSGQRVQIAFLEYTLSHVERYPLQLLQATEALRLILDSGTRPSDIVVAGDSAGGNMCLGIVSHILHPLEGIPPLGLREPLAGVLLISPWVSFDEDASSYKENVNLDICSPELLHAMADAYVPAVRNNWTDPYLAESFWWKGFPAKEVLNLCGGHELLKDYVLSVGRALSQAGVDIKTVECPLHVHVECILDAQVGLSTGEMAEEIWAWLPQAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6V0</accession>
    <name>A0A0D2C6V0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239525.1">
        <property type="nucleotide sequence ID" value="XM_016377955.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2C6V0"/>
    <dbReference type="GeneID" id="27330686"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03603"/>
    <dbReference type="HOGENOM" id="CLU_005477_0_0_1"/>
    <dbReference type="OrthoDB" id="4194555at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1316" mass="147206" checksum="09CCC219D19C7A0A" modified="2015-04-29" version="1">MTLRRSERIHFSNEDTLSASSSSRSLSEQLQDGWNLYHPPSRGLPQRTIPSNVVDFSVKHLFATDYGPKTLAQFLREEIDKLRQSATIYTGKGKGKMVETPHLADAAQPGVHHRPGYNHTPGDSRNDGPPKNMTHHLQSSVEGAFADEQSIHRAPSAHIPGLNASPSIASASLLQSQQPHPMESTAPRSLLVNAALRRSERLSNKAQNKDRGKMENASPYSDANAKSNREDGTKSPRDSENPFLQSVKGPGVSAGRDNVSDPYHSATSFETVTDSDRRSHFEEHTKTRRHLVRDVPSQLPIQKHNVPDHLRTRLRPRQTFCEGPVESSPNDANVDGLPSNTEHVASPDHNSPPTFRIPSKIPRRPNCNQHPQNYLPRHTSLSEPRLENTQPGRDEAQIVVIDVSKFVDRFFWNMSGSDEACSAQGDVGQALIGTLIPPSSVPSRFNYTGIVPPRLTAEVKRNFLESAQRITGSLKLQQLLVAYDLDLFLQGYEGARPINPSDVLALISDSDSVSFSYGSEDGLKPKSGVMQQHRSLDDFDEDRWMDIAQHLSPQDIRNLRLVSRALAQRLGPILFRNVVVNFGKRFFDIDDTGWESRCGHPPSNSVLKKHGDNINQFGIAFEYDLDGLANASEKVIEKEQDAWFGRFTWPTENYPRYPSLQAQEDLVDHNRPLLREALKHVTKASELGLCIDSGHGWLEGPDISDLALFQRRTKNGSAIFGDTFKTEDMWTTLGRNQYFHWAQQNTIDETTKWLNREACDDAGNSPHRASTSTTDEIDFVNHVGTTSIESFREKRKPANDFEDAHIGVFSSTRRIRPGFDSHSASVLGAHPSQWPLIFGGYNLAAELGGVNERLPTKIAHPYCSPLLPGSLTEAQAQWLMETAWAQRAFLSAYTTAVITNKQNFTNIHTLRISKLSSGLLPSMEQQEFWRSLPGLKNLKILVSPDWRQDYLIGDRAFATNMLISPAKAAERFTRFLRLHVTKLETLLSLTVGYAGGGEDAVGMFARNQHVLFAPIVEDPRDWLHRPARPPWVTRFDHVRELKFKNCWFTPWMLRAFMEKSKDTSLHTLNLDSVSMTAIHDSSIDNRILAQGIGSRCAWPRSSWLNETLSASTAWCQVLDDITPGVTLLERKYDAGMIDEIQHPRPKRAFRGHVRKLILKSCGYVKISLPKTGISGYSQNALLAHSHVPMDQGLFKRMQQYVKVPSSSTAGAGEDAETHNGPAGVLRAKRGDDLSRRHIMLSTIAPNGEPYPWLGTLTQCVHPVEKRVLEEAWGMTFGWQDDLARFGAVEDGFFEGGTGRFSGVIERDPSEEETISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C9N2</accession>
    <name>A0A0D2C9N2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240510.1">
        <property type="nucleotide sequence ID" value="XM_016375234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C9N2"/>
    <dbReference type="GeneID" id="27327952"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00869"/>
    <dbReference type="HOGENOM" id="CLU_006329_4_1_1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF4">
        <property type="entry name" value="ACETAMIDASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="259"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="586" mass="67031" checksum="58416C526E747404" modified="2015-04-29" version="1">MAWKRPIRRRMDASTRPNTHDVTESVLHTSTRSAHKARDEDESTHESQEGLDSEALASQGLARTSLSQFFQHGLPSSKWDVFNTLDRMRIVYIGTKVSNLSHLISLDQSSRPFLVYPHPEIHPSPSLTSRTYTPSAAQDSAQDIYAPFSKELRGELIESFFSKVHPIFPVVDEQSFRSKYDLAQDERPLLLLYAIMLVGAHVSQDAKVKRSRCTFKSLLFKRGKWLFDMRHENDRQHLVAAALLFTWHLENADTVSMNAYYWSGVACRTAYGIGMHRNILAEPDTPDRMPWRDRRLYRRTWWTLFQVEVMSALEHGRPSMIRLEDFDQGPLDARDFDEIQGSQDTLATHIHYCARNIELCYIVVDLLRLTSPGILKRDSQLDLETFQTRLANWAIGLPMTTDFWSLQLQLHYHCVVLHLFRLHSRSGDFGLGSINSVELCSGATRAILSVFETMAATDVLNQCYSTSVMALTAAAIYLSKEIQRSITNGAVLVALNHVRDLERVFPIATALSEYWPNADGLLKLFTNLADKFKILISDQQQPPAQQEGFDINALNEINWEDIFAYSHHHQSISTDDWMNTWPGLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CC20</accession>
    <name>A0A0D2CC20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_01583</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241220.1">
        <property type="nucleotide sequence ID" value="XM_016375944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CC20"/>
    <dbReference type="STRING" id="91928.A0A0D2CC20"/>
    <dbReference type="GeneID" id="27328666"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01583"/>
    <dbReference type="HOGENOM" id="CLU_028277_4_0_1"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="154"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="377"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW21004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="425" mass="49189" checksum="952261E63D8C10A9" modified="2015-04-29" version="1">MARPRRTSSNLGGDPRGDTSAPAWATMTPKQPLQPSTSEKELRPHSKRRKARSAFRKWKNLSYRHTWLNPLILMVGILGAYFANPGEQNPLHKAIFLSYPLGPDYPGGPNMYGKGYADWAFVGFYTIVLTFTREFIMQKLLRPLAVYCGMKKRGKQSRFMEQVYTAMYFAIFGPFGLYVMKQGPLWYFNTTAMFEGFPHRKHEGVFKAYYLLQAAYWAQQAIVLVLQQEKPRKDFRELVLHHIVTLSLIGLSYRFHFAKMGIAVYITHDISDFFLATSKTLNYLDSIIVGPYYFLFMVIWIYLRHYINLRILWATLTEFRTVGPYELNWETQQYKCWISQVITFSLLACLQAVNLFWLFLILRIAKNFVFNSVVADERSDDEDEEDDDEPVDKDAKPNGTHPVVLVNGLPVEGDSKAEGVRKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y4J6</accession>
    <name>A0A0D1Y4J6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230077.1">
        <property type="nucleotide sequence ID" value="XM_016386269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y4J6"/>
    <dbReference type="STRING" id="91928.A0A0D1Y4J6"/>
    <dbReference type="GeneID" id="27339045"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11962"/>
    <dbReference type="HOGENOM" id="CLU_015320_1_0_1"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="1">
        <location>
            <begin position="76"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="219" mass="22603" checksum="8C49623584D43B87" modified="2015-04-29" version="1">MGGDLEKECKKAAQILKNFVDKKRIPPEVVKNAKGLAIFSGFRAAMWLAGAGGSGVIIARLPDGSWSPPSAISVFSGGVGVVYGIDVYDCICVLNTQEAVDAYAKGETTLGAAATMAAGPIGGTADITTKDVKPIWTYTKSLGLYGGITVDGTIIKEKSDVNARAYGGKITAAQILKGEARSVPSGQLPEVLKLAEGNAADSKILDSISTEPTPGDLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y5T3</accession>
    <name>A0A0D1Y5T3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP cyclohydrolase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230487.1">
        <property type="nucleotide sequence ID" value="XM_016385543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y5T3"/>
    <dbReference type="STRING" id="91928.A0A0D1Y5T3"/>
    <dbReference type="GeneID" id="27338316"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11233"/>
    <dbReference type="HOGENOM" id="CLU_029639_1_0_1"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="7">
        <location>
            <begin position="112"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="6">
        <location>
            <begin position="345"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW10271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57146" checksum="344ED14F04B89B53" modified="2015-04-29" version="1">MASTENGAPPQIYSAVLEEILTTLKKMQGDHAQLAASVEALQSKVGVSASINQLRSSSTTNSGLGSLGSPSLDPVQLTQSANGTASPPSADGTPLPKAPGSPTARKSSAVSRIILTTYPGQSGIDPIPLSWGEGDAAKRGPVVVSRHHNTIRRRNAIGAHGGSYSIYHALAVASNHLDMEHKPDFTNTEPAALIGPFPAWGDKKKIVAMDPFGHLAPWLYKDVMQSQDIDIKPTIAVTKAHMKIPELEQSVRAGRLKPDGKICLNETGELSVTKFAVEPVWYLPGVAERFGIEESALRRALFEHTGGSYPELVTRNDIKVFLPPIGGLTVYCFGDPAKMADRSARLALRVHDECNGSDVFGSDICTCRPYLIFGIEEAVKEAQAGGSGVVIYFRKEGRALGEVTKYLVYNARKRGADRASEYFKRTEDIAGVKDMRFQALMPDILHWLGITKIDRMLSMSNMKHDAIVDQGIPILERVPIPDEMIPEDSRVEIDAKIHAGYFTTGKVMSLEELNAVKGRSWDDIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y6W4</accession>
    <name>A0A0D1Y6W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230832.1">
        <property type="nucleotide sequence ID" value="XM_016385888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y6W4"/>
    <dbReference type="STRING" id="91928.A0A0D1Y6W4"/>
    <dbReference type="GeneID" id="27338663"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11580"/>
    <dbReference type="HOGENOM" id="CLU_019274_0_0_1"/>
    <dbReference type="OrthoDB" id="5400327at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF5">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="253"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="613" mass="65896" checksum="4B5A5D32F5D783DA" modified="2015-04-29" version="1">MPCFKGLAVSIHTPNGPIPEYSVQKASRLSRISAYIPVPPAKIPDDSTTGKPEQSTFAISITLLMPGQEVPYSTPKATPDHPNPKPKFVGGLPGHTGERGSYSSPVVPYVPLTTSPNETIAAYIYFDGRAKEEVATLLRKGEETWVNSRWVSVPEKEGGGLAEREFLFREVGLERWLNGLDLDGKDAAATIERRRQKLEKKMEKRRRKRKDVTGSDDEANGRFTGSRRKSTLRYGENGELQDVSDDEGSLSDSASSDDDDDDPIPEAAGQIKVALFRVLASGEIKRGEYSPQFDAHDDSEESGTEAAPNGEGKSRADVDHTTSFAKPKTLDPKTISTQTVTGIDPTDKPYAVFTFLYRGERQLQKMGILPTPKSDKTPSSAKRRSIAVELPKLGPLKKEGVAGFSGFRDAETRRTRKGKRGSDDEMDSDSEDDSGIIGKMEDINEAEVKREPGLLAPEDAERTGQVAEGIRKMKLKRQHSAEPLNSNGVAEARKSSKSGSPSTASTPKMGTDELGTSPGTSNFVNGVAQSLKSEDESFMVGSPMKRQRASVAEFDGDIKGRLMGGVPASAATIGEALGSAGAPQAASDASNPSGLQFGGALQKSSATDDDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y734</accession>
    <name>A0A0D1Y734_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230927.1">
        <property type="nucleotide sequence ID" value="XM_016385983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y734"/>
    <dbReference type="STRING" id="91928.A0A0D1Y734"/>
    <dbReference type="GeneID" id="27338758"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11675"/>
    <dbReference type="HOGENOM" id="CLU_013260_4_0_1"/>
    <dbReference type="OrthoDB" id="3014581at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46481" checksum="7A8D622DAAEEE2FD" modified="2015-04-29" version="1">MLLLEWNSEGQSAEFYALKSIAYQKAISMGIHRLDAGAGGKDGNVIESELKRRLWWHLAASDWITASIPGNQEGMYSVNPAHARVTYPANLDDRVLSNSHPPVNLPEDQPTSTSFLIQRAKFAELCRQLADSIQNAGITEESQPCNLTYEFSHRLRRFEEDLPWFFRMDEENKDKANALALNRPYLVPQKHFLLFGIYSRIVRLHRPFLSMKLREPEFSESRTVCLQYAEKILKLRNSIDLSGICHCVNSYSIRQHTFGALLLLSMDSMLETDMFRAQPRKAELIEISKTLRDKEMSSNRSSSGIVFGIDKLIDLLRKSTLDTPVLDSSSSSTERTAQVTLQNPSRLPLSDINAPVTARSLPDYFSEPSHTTSPMPMPMPTPIFSEVTLDDFLNQIDGMEGFDWDGIFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7I6</accession>
    <name>A0A0D1Y7I6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231092.1">
        <property type="nucleotide sequence ID" value="XM_016384490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7I6"/>
    <dbReference type="GeneID" id="27337258"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10175"/>
    <dbReference type="HOGENOM" id="CLU_064985_3_0_1"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="166"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="321" mass="34535" checksum="842569B69FECDEEA" modified="2015-04-29" version="1">MAVDDSTALSIAELAIYTVLVPMTFYLFFRHGIRSTLGYMYLFAFETLRLVSAGLQISAHSQHKTSSATGSIIASVGLSPLILALSGFIYELSSYSYYYYDADADAAPERGNAYHRHRRLLIVQEVLVHLGAYTGIALAASGASKLAKSSFYSSSTSSSSSSSSVTTTTSASDIEHAHTLQETGTILILVTWIGQVYLCARLCVTRGVLTPVSVSLGVACIFVGVRCVYGVVYAFDHSRSSPVNPVTGSFAVKVTLVVLVQLVVVVALLVVGFLTRDIARDHGVKRRWWRRGGRGGWYTTTSSGGPVEIDRGSAIPLRSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y992</accession>
    <name>A0A0D1Y992_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_10822</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231737.1">
        <property type="nucleotide sequence ID" value="XM_016385135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y992"/>
    <dbReference type="STRING" id="91928.A0A0D1Y992"/>
    <dbReference type="MEROPS" id="M67.A14"/>
    <dbReference type="GeneID" id="27337905"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10822"/>
    <dbReference type="HOGENOM" id="CLU_023304_4_0_1"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000033">
        <property type="entry name" value="AMSH-like protease sst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="317"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW11521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="498" mass="55874" checksum="C83ED9A893E40533" modified="2015-04-29" version="1">MSSHRGSPTSPRPPRSVQQITKVAQEYEYDAQIPLRIWLRSAQAMLKQADTYMREGDEETTYMLLFRYAHLVLSQLPQHPQYRDKTATHLQGLMQEAEREVNDVLKMLDLMKPRINERYNRYIKVVKEREARKIAQTQPYQAGPTPAIPSQRTQPLQAHENKEFAVRLAQKEISRRAANRQNASTMGSDGEDLSTRLQELRARVDGRRLQSLHSGGAQASPSVDSSLHYHYPSVPSQHLPPTASFSSLLPSQQSYGRDIPLSPPMVPPKPRSEIAAPPPRPDKVSAQPEVESRSATPEPTHVFAPAAYLENGEPLRTIFLPPELRTTFLRIAYKNTLANLETCGFLAGNLIANAFFISRLIIPSQTATSDTCEMTNESQLFDYVDTEDLMVLGWIHTHPTQTCFMSSRDLHTHAGYQMMLAESIAIVCAPSKGDVTHGGDWGAFRLTDPPGKKAILNCDQPGIFHPHAIENIYTDALRPGHVVEAKGMKFEVVDLRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCS5</accession>
    <name>A0A0D1YCS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_07937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232967.1">
        <property type="nucleotide sequence ID" value="XM_016382264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCS5"/>
    <dbReference type="STRING" id="91928.A0A0D1YCS5"/>
    <dbReference type="GeneID" id="27335020"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07937"/>
    <dbReference type="HOGENOM" id="CLU_030571_1_0_1"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="366" mass="40849" checksum="B92910C2AC090B0D" modified="2015-04-29" version="1">MAFPEQPPHLHIPDSPNTVKVSVINTACWMSNFPMWTFLEPLMPGHHEMKAGSYAFLIEHAKSGSKYDTLLFDLGVRHDWETNSPPAFIAAIKEGKHSIEVKKDTATILSENGVNLADIGGIVWSHWHFDHTGNPGNFPGTTDLIVGPGFKANLTPGYPTITDSHIDERLWADRELREINFVEEGKGLKIGKFDALDLYEDGSFYLLSTPGHTVGHLSALARTTADPPTFIFMGGDIAHHGGEFRPTPYLPLPANIHLHPVKEPLLSCPGEIFVALHPKKSRTEPFNNPTTAPGSWHYNPQEATLTIEKLTEFDAYEHIFPVIAHDNSLLDVVDFYPKSANDWLAKGWKQKSLWGFLSDYEVVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YEW1</accession>
    <name>A0A0D1YEW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233812.1">
        <property type="nucleotide sequence ID" value="XM_016383109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YEW1"/>
    <dbReference type="GeneID" id="27335868"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08785"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="238"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="428" mass="46756" checksum="F46394C311BE3AC6" modified="2015-04-29" version="1">MTDEASKETGEVVIPIAPAAPLVHYDVNEEPRYGWVVCGALSAINGFTWGILASFGVYLSYYINNATFPGTSDLDYTFVGGVNFSTALLSAPLVNLCTRKFGTNVPMYCGCFMFAGGFVAASFATSFWHLVLSQGILVGLGTGFVWQPATPVLPQWFNKNRSLAQGIAASGAGVGGVIFSAATTPMIDNLSLAWALRITGIVSFGVLLVASILMRDRNATVRPEIKIFDAGLLRRRPRVWLLVGYSFFNILGYIVTIYSLSAFAVSIGLTQHQGGTVTTVMNLGTALGRPFVGVVSDRCGRMTVITLLTAFNMVIIFAIWIPLHSYGLLIFFGLLIGATAGLYWSTIAPLCAEVVDLQELPSALSLMWLTVSLPSLFSEAIALEIRLPHSNRPYLWPQIYASLTFLISSLFMFELRRRKWGWAREKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YH64</accession>
    <name>A0A0D1YH64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-ketoacyl-CoA thiolase B, peroxisomal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_07083</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234517.1">
        <property type="nucleotide sequence ID" value="XM_016381415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YH64"/>
    <dbReference type="STRING" id="91928.A0A0D1YH64"/>
    <dbReference type="GeneID" id="27334166"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07083"/>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="31"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="293"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW14301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="43942" checksum="B38D0CC628136C9F" modified="2015-04-29" version="1">MATQRLGSIFSHLSSTKTGVAGITQKNPDDIVITLAIRTPLAKGKKGGFKDTDLDHIVYSLLKQVLEKSKIDPALIEDVCLGNVGDSRAAYKVRAASLAAGIPHTAGASSVNRFCSSGLKAVQDIANQISLGSIDIGIALGGESMSNNGDRDLPFSPSLLANQEAADCLQPMIQTSENVGSDFNISRRTQDEYACESFRRAEVAQKAGWFDDEIVPITTTIKDPKTGQVTEITLTKDEGPRYGTTVEALGKIRPALPQFGDKTTGGNASQVTDGAAAILLMKRSKAIELGQPIMAKFCGATVAGVPPRIMGIGPSAAIPKLLSKFQLTKEDIDIFEINEAFASMAVYCLNVLGLDHAKLNPRGGAIALGHPLGATGARQICTILSEARRTKKKILVTSMCIGTGQGMAGLFVNEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YHU0</accession>
    <name>A0A0D1YHU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234692.1">
        <property type="nucleotide sequence ID" value="XM_016381590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YHU0"/>
    <dbReference type="GeneID" id="27334343"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07260"/>
    <dbReference type="HOGENOM" id="CLU_2333621_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="98" mass="10854" checksum="C036A1AE193C8009" modified="2015-04-29" version="1">MGAEKKKNSNHNEKKGGKDLDLLRRVIASTANDPAASTISVDYLELQKSYPKHNVRALQQKVCRLGEKTKGLGTKIRLVGRGKEALRKDRGRANKGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIA1</accession>
    <name>A0A0D1YIA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234882.1">
        <property type="nucleotide sequence ID" value="XM_016381780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIA1"/>
    <dbReference type="STRING" id="91928.A0A0D1YIA1"/>
    <dbReference type="GeneID" id="27334533"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07450"/>
    <dbReference type="HOGENOM" id="CLU_013985_4_1_1"/>
    <dbReference type="OrthoDB" id="2129362at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="178" mass="20241" checksum="E9AC5DD25F3AFCA1" modified="2015-04-29" version="1">MNVTVRAAVESDLPQVRQIYEYYVLNTVVSFLVQKPPPDYVAERYHDSVARHLPYLVAVDEGGTVVGYSYASAFRGFMLGYGHSVEISLYCHPTHQKKGIGSRMIKRLIELLRQTKHVSKEVGHEDHPVEVDVRKVFAVMAIDEEAPGQGMALRDWYKRWGFEEVGRLKGVGFKKGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJW6</accession>
    <name>A0A0D1YJW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MATE efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05321</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235492.1">
        <property type="nucleotide sequence ID" value="XM_016379665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJW6"/>
    <dbReference type="STRING" id="91928.A0A0D1YJW6"/>
    <dbReference type="GeneID" id="27332404"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05321"/>
    <dbReference type="HOGENOM" id="CLU_012893_1_2_1"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048279">
        <property type="entry name" value="MdtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW15276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="56055" checksum="03769C7085A1A377" modified="2015-04-29" version="1">MTADRAQTLHPRAAATRADNEGLISETSALLNHADSGLAQESSGPDGCIKGPDATTKSIGDLTETTWQHESKVLAGYSVPMVLTFLLQQSLTVSSVFAVGHIGTTELASVSLATMTANITGYSVFNGLATSLDTLCAQAFGSGRKELVGLYTQRMVYFLWLTTIPVGIIWFFLAEPILVRLVPDATVAHLAATYLRIVVFGAPGYAAFEAIKRFVQAQGLFSAPLYVLIICAPLNASLNYLMVWHLQWGFIGAPLAVAVTHSLLPIVLVLYIRVSKTNNAGGDAPSCWTGFTPKAFRNWGVMIRLAIPGLLMTEAEVLAFEILTFAASRLGTTVLATQSVLGTLVLLEFQVPFALSIAASTRIGTHIGAARLQAARMGLKVTLFAAILVGTVNMTLFVSLRGVIPSLFSSDPEVISNVASIIPLFAAFQMFDALATTCNGILRGMGRQEMGGYVQLFCYYVVALPVSFSLGFALDWQLWGLWTGVALGLALVSAIELAYIFHTDWERSIEEARLRNQESEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKL4</accession>
    <name>A0A0D1YKL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BUB protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235717.1">
        <property type="nucleotide sequence ID" value="XM_016379890.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1YKL4"/>
    <dbReference type="GeneID" id="27332630"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05547"/>
    <dbReference type="HOGENOM" id="CLU_002115_1_0_1"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="70"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="733"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="828"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1079"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="841"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1083"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1399" mass="155016" checksum="D6EA5D76E636C333" modified="2015-04-29" version="1">MAVPVAADNDLINFDIIETHKENIQSLPGGRSAKQLAAILTPRPSGRPGLQPEPTLNETKTLNDAIRQEYEIELQSIADADDPLDIYDRYVKWTLNSYPSAQATPQSQLLPLLERATKAFLTSSLYKNDPRYLKLWLHYIRLFSDSPRETFAFLARHGIGDALGLFYEEFAAWLEGAGRWVQADEVFKLGIEKEARPTERLIRKYNQFQQRFEARPQTDNEPSSPALPTVRPALAAKIDPFASSHRGNDGQAPQQQQNGAAARAANSSRSGKPKMAIFSDADNAAPPPASTSTNGWDNIGSIKERKKENTIEARPWAGEKMKAGGRVGTVPKMEIFKDPSLQATSRPQESVQRPGDVVNPRTGRIERVFVNVEAIYPSNDQEFSFEELRAMSRGWLHRDWRQPEEPSSGTPLKILSANGRSPRKSRSKGSKAQEQEDIENLSESFQEKVDLNDTSQGSLSGHDVSTQSMVGMPGSQTLSQPQSQSQQPRDKKYKIREVKQETQTVKLRLQSPTGKKLKRKNTAEPTMTFHSKAATNEIYDMFNQPLRKSEVTKDDTQSGEEAEFAEDVDDGYSTTGDAESTGTGRGFGADSEYGDDTLASQFDHTESQSQTQTHSQPESVSPWSDFTASKHVPRLDSRNTSSSKTSLSSNKAHTKTKLKDKHRHAMADDVTEGLASSSQNATQTSGLGSGFDTQAIAAIANCNFDDMDTKAIAMIAGDVDDEEEDDLEIQDPLHALSHSETKGAAEEGGIAEEDQETVHEDDTRDNLSTPVDDVFTEHREISHKPRFIPLPPEDYEPTPVRPYRDPALVAQNKLPFMTPIVERTESSLAPSTVFNDPDYFTSKTPSRLQRTYESPSQVQIDKLLLSSPQQQDGTPPSSGKRKYEHTGITEEEAASCSPRQRKAPGRGRPNPNGHIPFPIAKASPASTKDEESLFKTPAVPDQSPARSITQSVVRHKGPVVADLQCNPCDDVIRQQILTAVYPPLSSYVGYHDHSAEALGQYSVLKSYADKLLKSKAKGSPRKSQGSKDAAIKAVPPLLKFTGASRVYAVKRELGAGAFAPVYLVESYDPNENALAIADDVEDKESSSPKKSMDSTRQPLEALKTETPPGTLVWEFHILRTVRQRLGSAARTMQSIVLAHECHLYRDEAYIVLEYSPQGTLLDLVNLARNENMKAGKPAEGLDEVLAMWFGVELLRSLEDLHHVGILHGDLKGDNCLVRFTGTDVTGPYEPLGGSGWNDKGLKLIDFGRGIDTRMFKAGAQFIADWPSCATDCAEIRECKPWKWQIDYHGAAGVIHSLLFGKYIETIPVGGSLGPGQKKEWKLKENLKRYWEKEIWTEVFGVLLNPATVQDGEEMPIQRNLKQVRMRMEKWLTEEGERGGRDLRGALRKMERLVAGNKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMC2</accession>
    <name>A0A0D1YMC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">STM1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236387.1">
        <property type="nucleotide sequence ID" value="XM_016380560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMC2"/>
    <dbReference type="STRING" id="91928.A0A0D1YMC2"/>
    <dbReference type="GeneID" id="27333305"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06222"/>
    <dbReference type="HOGENOM" id="CLU_043312_1_0_1"/>
    <dbReference type="OrthoDB" id="5426471at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019084">
        <property type="entry name" value="STM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09598">
        <property type="entry name" value="Stm1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STM1-like N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="351" mass="37628" checksum="9CDB2456B9007BBC" modified="2015-04-29" version="1">MADVKSKNLYELLGNTSDQDSDREPEPPTKAVDKPAARVGKRDAPKAAPTEAPSARGRGGRRGGFTGNEAAFRDRATGRTYNRDQPTEGEGADGFGNKPGRTQGSAGTRRTGRGGPTQRRGGDRHVNRTGIAEHPKQAGHGWGEATGEGEWADEKAGEAIAKQEEKEGGWDAGAQAEGWNENAEPVAIPEGGEAIPDADAEPESNHKSYAEYLAEKAAQKLQGLGLKEARAPNEGTKEDKKWKSAKELTKEENADYFKGEEKARRERERATKKEFLDIDYSFKEQPRESRGRGGRGGGRGRGGSDRGDFRGRGRGRGDRGEYRGRGRGGRGGDAPGVAVNDESAFPSLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMS2</accession>
    <name>A0A0D1YMS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CRESS-DNA virus Rep endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_06397</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236562.1">
        <property type="nucleotide sequence ID" value="XM_016380735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMS2"/>
    <dbReference type="GeneID" id="27333480"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06397"/>
    <dbReference type="HOGENOM" id="CLU_1354637_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049912">
        <property type="entry name" value="CRESS_DNA_REP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00799">
        <property type="entry name" value="Gemini_AL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55464">
        <property type="entry name" value="Origin of replication-binding domain, RBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52020">
        <property type="entry name" value="CRESS_DNA_REP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRESS-DNA virus Rep endonuclease" evidence="11">
        <location>
            <begin position="46"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW16346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="202" mass="22948" checksum="55C19B86470B85B4" modified="2015-04-29" version="1">MPRLFEEGGEDSSLRKGQKNINVVKPVTAKRPVPYRATTNAWDGFRTTGQRFLLTYSQLRLETFKISELGQHLMSLFNNPVTCVLAAKEKHKDGGDHVHIYLDVGIEVQIQGSRFFDYCQRHPHIKAITKTPHRAAAYVMKDEKVFFRHGEVPGKRVVSLCQQGTTSKHSFERRRHGLVALGGSSTVSMEMLNKDIERLTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNQ4</accession>
    <name>A0A0D1YNQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236957.1">
        <property type="nucleotide sequence ID" value="XM_016378280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNQ4"/>
    <dbReference type="STRING" id="91928.A0A0D1YNQ4"/>
    <dbReference type="GeneID" id="27331013"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03930"/>
    <dbReference type="HOGENOM" id="CLU_033342_0_0_1"/>
    <dbReference type="OrthoDB" id="4146419at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="410" mass="45587" checksum="AD0B119E1C43B879" modified="2015-04-29" version="1">MSRFSEDRTLVDSFETLTRIPSPDISAHPASSVKGKAKATVADDRPNLITTSSPVQIRSWAEDRARIDAEFRRRPGFDPYRNYDRVRADFIPAPVEGRNAFAASAINLGMNESFRSRPLITEPPKSPFIATRRGIRRRSKRKSDDSDQTVLKMRASISQLNIDHKGWADTETTTGRNASSISIFRPKTPSKGFKTSPTPVSETVDTKKSGLRKVTGLFKQKSEKSLDTTPLPAPVLSSTPEESVVNLPAYRLNTEKHLRATLNCPTYDYSETDPLPRHPNTARGWKSRNLKCTTCVDVCCALCGRACCAYKAAYLAMKTHKDNPESLARAQEILGNISILFPYGQEAPTFLRCSNGAPDDKFGCGKMICPDCCGQCPNPCCADIQCKRCKKHPFLECIWHDENVATLSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQ43</accession>
    <name>A0A0D1YQ43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Haloacid dehalogenase, type II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237572.1">
        <property type="nucleotide sequence ID" value="XM_016378895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YQ43"/>
    <dbReference type="STRING" id="91928.A0A0D1YQ43"/>
    <dbReference type="GeneID" id="27331631"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04548"/>
    <dbReference type="HOGENOM" id="CLU_045011_3_0_1"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="242" mass="27683" checksum="C50EB2E192D4FEFA" modified="2015-04-29" version="1">MPDTKIKAVFFDFMGTCLDWHSGTIQVFPSSISQSERSKLALEWRHDYFDANAARLAAEQPPEDIDITLRTTLNALLEKHSEYKIRFDEQTKDRCITAWHSMPAWPDVAPAIDKLKAAGYEIFVFANGTPRLQLDLCKTSGLKFDMLFSSELLGVYKPSPESYRKTLDLVKVKPQAAVMVAAHAYDTRGAKEAGMKTVYIHRWTDDINEDMEVVRRENDFFLEDMTDLPAVISQMSILRHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUN7</accession>
    <name>A0A0D1YUN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239177.1">
        <property type="nucleotide sequence ID" value="XM_016377607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUN7"/>
    <dbReference type="STRING" id="91928.A0A0D1YUN7"/>
    <dbReference type="GeneID" id="27330333"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03250"/>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="OrthoDB" id="10019231at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF55">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="261" mass="29132" checksum="507F7AD1B7EBB699" modified="2015-04-29" version="1">MSYSECCQKGSLWDGTPQGEEKTLGPNKAYMTGTNPDAAVMLIHDAFGWKFPNTRLLADSYAKEADVTVYLPDFFGGESLGPFETIADPTQWHKLDLAGFMSRNTKDIRTPEIFECARALRTQHEYKRVGAIGFCFGGWAVFRLGAKSHNDNDNDNGEPLVDCISTGHPSLLEKTEIDAVGVPVQILAPEHDVMFLPELKEYANKVIPTLGVAYDYQYFPGVEHGFCTRGDVKIANGQEYKAMNRAREAAISWFKVWLHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YV31</accession>
    <name>A0A0D1YV31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239357.1">
        <property type="nucleotide sequence ID" value="XM_016377787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YV31"/>
    <dbReference type="GeneID" id="27330516"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03433"/>
    <dbReference type="HOGENOM" id="CLU_006329_5_1_1"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="734" mass="81366" checksum="19D4E201B69EC6B4" modified="2015-04-29" version="1">MRPGSSEHAPSHRTRAVKACKRCNQKRIKCDAFECGTPCSKCRQSNSEECVLIQSRRGTHPRKRSKPNPAVPELAEASVGVDADTGDDAVAMPAVSETTEQRPLSDPTPGDGPPPLPQTVQSVRVGSQAPATVPNGFPVSASTTSSTDLASPEAAFSETSAKSYREISWAAMFDHFLDGRRRDQKDTIDKCSITYLGESFPLAMVLEEFKEGGRPRLHHAGPPLTEDQARAEPTSENHPSHMLPEDIAFLQAKDAFVAPSQEILDALIANFLDRVWPIYPVVNRQEFLQQYKAKKVPWILLHALCFISATFCPLAILHRAGFTGRKQARVSYYRKAKALFDTGYESNKITILQSVIVLTCWGGGPNNYWNFYSWISTGVTIAEALGIHRSTAGANMHPHDRSLLKRLWWILVIRDASCGTLVGRPFRINTDHSDTEMLTVEDFEYDIQSPDFVNNPLHDVCGLYQIHMSKLSLLLREIISTRFDPNRAQARMANLHETLQEWHNALPPTLRCSENDKSSNPFATCLAILYDHHLILSHLGRPTTGATSTTSENGSLGGGAPSRPITEVAAQRISSLACTFTRKNESLVMPHEVFQGLFLAQAVFYTQMKSPLPLVSQLGFQALNSCQMVWHDIYEAWDPAPWISKLFDNLIGNRNQDIESNEDDLRNSNVPGNGGPSIGNGIDLDGINGYVDWQNHPTLGFFDMSQGEETFPSSTDYAMFPNYFGATEPISFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXJ0</accession>
    <name>A0A0D1YXJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240192.1">
        <property type="nucleotide sequence ID" value="XM_016374916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXJ0"/>
    <dbReference type="STRING" id="91928.A0A0D1YXJ0"/>
    <dbReference type="GeneID" id="27327634"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00551"/>
    <dbReference type="HOGENOM" id="CLU_049915_2_1_1"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF3">
        <property type="entry name" value="5',5'''-P-1,P-4-TETRAPHOSPHATE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="12"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="207"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="339" mass="37775" checksum="D16D2BEDA33D3A73" modified="2015-04-29" version="1">MSEADMALGLAEHLQSLVSRKFQEAYRKKALLFSDTALQVLRIKQGSSFQLRYCPALANKPKGTEKTESRGPKFDPFAKPSPDLLITSIPSNDPSHILVLNKFPVIHNHFIIATKDNKPQTGLLEPADLGMTYECLHAWQTHQSDTASQRLFAFFNSGEHSGASQAHRHLQFLSMEDMLGSESQDWGLLIDRMTVPAHPELPLFHDPSCPLLHFSTPLEGRASAEILFSKYQLLLRAALSAASHPGEQLNEHINIERDGETTFSYNLAMTRDRMAICPRSREAVAVPGIDIDSSVALNGTILAGTLMVKHEQEWNILRETPMLLENMLASVGYSPAIWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXQ2</accession>
    <name>A0A0D1YXQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF962 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240252.1">
        <property type="nucleotide sequence ID" value="XM_016374976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXQ2"/>
    <dbReference type="GeneID" id="27327694"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00611"/>
    <dbReference type="HOGENOM" id="CLU_081702_1_1_1"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22408" checksum="D6D79616FB139940" modified="2015-04-29" version="1">MALNLEKQLRFYGAYHHDPVNVAIHIVGVPIILWTTFLLGTNTPAIVDLPPPIAVPYLELNAGTIFCLCYCALYILLEPVAGTGLAALLLAGTAFGKYLTVTHGMTANFWALAGFVASWIAQFMGHGLFEGRAPALLDNIFQAFFLAPLFVWLEILFALGYRPELKHRVEKMVQQDIAKYKQSKAEEVNGKTNGAALNGRTKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZ85</accession>
    <name>A0A0D1YZ85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cleft lip and palate transmembrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240807.1">
        <property type="nucleotide sequence ID" value="XM_016375531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZ85"/>
    <dbReference type="STRING" id="91928.A0A0D1YZ85"/>
    <dbReference type="GeneID" id="27328249"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01166"/>
    <dbReference type="HOGENOM" id="CLU_019907_2_0_1"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="73604" checksum="521548FFB8D03AE7" modified="2015-04-29" version="1">MPESRGTGTGGTAARQEETGGSMFKSLLQGLAIFMITQFAVNQFFGSKTTPSGSAAPKANVNFEERVDATALTNYSAIPYNVAPIWPDGGSVDIQVYVSPNTAIFPLSKQPKDTLVLDEKNFQIGDYEENREIHTTIAIPKEVQHNGTLWAHFFVALTGNELDPTASTFDPAKAYTFSKPLNHYLPKKKARKLKNLLEKTEEPEEELEEPQGPQVGSFYHPNFTLAVIPNSGVQNWRQMHPALRKNTVLERTGARDESGMNGWYYPVIFLNTFWQLRSHMTELNDTVQEMPLNIDLYNMPNWKYNILATVDEGMKQNQQQAASGGPMPAGGDGSEFEKFKEILLDTNAYLLGTTFVVSILHMVFEGLAFKNDISHWRTKKDNVGTSVRTILANVFMQTVIFLYLVDNSEATSWMILASQGFGILLEAWKITKTVNVRLREPGPDSSFKFLPYVVVFEDKHKLSETERKTQEYDQIAFRYLYIIAVPLLLAYAVYSLIYETHKSWYSFVIETLVGSVYAYGFLMMVPSLYINYRLKSVAHMPSKALTYKFLNTFIDDLFAFTIRMPFLHRLATLRDDVIFFVWLYQKWKYKVDYTRVNEFGQGGEDEEDETSSAEKPKELEGQDTKELKPSAPVASASGKETKSGAKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z015</accession>
    <name>A0A0D1Z015_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241122.1">
        <property type="nucleotide sequence ID" value="XM_016375846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z015"/>
    <dbReference type="STRING" id="91928.A0A0D1Z015"/>
    <dbReference type="GeneID" id="27328568"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01485"/>
    <dbReference type="HOGENOM" id="CLU_130569_0_0_1"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="117" mass="13432" checksum="32F96F4D7132DDC7" modified="2015-04-29" version="1">MAPSQIQVVISSLQRLLKEENSYYKEQEQQEARIAKLEKDKTDEDGNREFTLKQERQALEETKKVIPTLRERITNTREKLENMLDTAGSDEERDAAVQVLKAAKEQQKNDPIAGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z095</accession>
    <name>A0A0D1Z095_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241192.1">
        <property type="nucleotide sequence ID" value="XM_016375916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z095"/>
    <dbReference type="STRING" id="91928.A0A0D1Z095"/>
    <dbReference type="GeneID" id="27328638"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01555"/>
    <dbReference type="HOGENOM" id="CLU_045151_0_1_1"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000298">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="104"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="371" mass="41935" checksum="FF8093517AE0AC99" modified="2015-04-29" version="1">MTDKLPPNLLALFQPRPPLRYIPPQDTAPEERAVKTSQLSGIAAFLPQFQEYKETDEYHPTESWLQQRDRKRLEKQKWLEQMKDENFQGYKPREDPKIKGDAEKTLFVSRLSYDVKESDLEREFGRFGPIERIRIVKDETTPKPKKPHRGYAFIVYEREKDMRAAYKESDGLRIKDRRVVVDVERGRMVPGWRPRRFGGGLGGRGYTKQAPAKPTFGAPQAGFGGGFRGGFGGRGGFRGGFRGDRGGYGGRGGIGYQGGGGFGGRQGGYSNGPPPPNAPSGPGGRGGYGGGYEDRRNGYGGDRGGTGSNQDPLGGRDRGYDRDRDRDRNRDRDRDRDRDRYGGGRRDDDYSSRKRHHDNDGYDDPRQRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z1M1</accession>
    <name>A0A0D1Z1M1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_02111</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241747.1">
        <property type="nucleotide sequence ID" value="XM_016376471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z1M1"/>
    <dbReference type="STRING" id="91928.A0A0D1Z1M1"/>
    <dbReference type="GeneID" id="27329194"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02111"/>
    <dbReference type="HOGENOM" id="CLU_010189_4_4_1"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="44"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="269"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW21531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="55808" checksum="50B9143C51192882" modified="2015-04-29" version="1">MDIPLILLNIFFPGVSTSLKSIIAKSGLESLPHLQILIYCTVLFLVTSWAVGYLLQQVFKWFSASIVVHSQDDIYNALTAWLSEQRSLKRSLSLQAVTAGNLSENSNPPNVLDESAVSKTFRIATSATRNASIEFEPSAGIHWFLHGGRIFQLLREERQSASVIGGSVSTRVAETMKITTLGFSTSPIKELFFLALKRQHERELTQTVVFRSMQLYPGRSIWSRLGLRQARPMDTVYLDKGLKDNVIADIAEFLNPNAASWYANHGIPYRRGYLFYGPSGSGKTSFATALAGHFGLDIYTTSLMDASHTEDSLISLFMQLPRFCIVLLEDVDCAGITRPISEPAQEIDECGTLTTREHSALRTGTARSPISLSCLLNAIDGVSASEGRVLVLTTNYRERLDDALIRPGRVDYQVQFRLASRPQARELFWRIYSPHPSGSAQNISKFPLTVTSNDSKRISNLSDEFAALVPESRYGLADLQGFLLARKSSPEKAIADIKLRGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z9Y9</accession>
    <name>A0A0D1Z9Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230053.1">
        <property type="nucleotide sequence ID" value="XM_016386245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z9Y9"/>
    <dbReference type="STRING" id="91928.A0A0D1Z9Y9"/>
    <dbReference type="GeneID" id="27339021"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11938"/>
    <dbReference type="HOGENOM" id="CLU_313748_0_0_1"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025040">
        <property type="entry name" value="DUF3984"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13136">
        <property type="entry name" value="DUF3984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="50"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="933" mass="105608" checksum="3EAB8EAA1C3DE029" modified="2015-04-29" version="1">MAYSQRVAYRHKSLESPGEQIRLLTIAPGLESQSVQCSITHHRLAAAPEYEALSYMWGSKDNPVEISLKDDQEQGTFSVTQNLHQALCRLRYQDRERVMWVDAISINQGDNVEKSSQVPRMKKIFENAKRVIAWLGEAGEDSDRAIEWIEELAESLRNWERAGFNTNFVDSWITIKLLNILQQSDRDGTWTALWRLLSRDYWGRIWIIQEITFARELVLCCGRKYFLLPGLVKVLSELLLMRGHHHEHPRRWPEAFEKLFNGSNLLLMEGLRQTRTSPKSPQLFLFTLQSFCHSRSEKPHDQIYALLGFLEGSKRPYQGVIHVDYERTVEDVFTDVVEYCISAPRSIDNLLQQDPIASNDDDYILSSAVAMLTKRPHGPLSILCAAFPFGRDPGWPSWLPDWRRSASFATMGKVGDELFQASADHPAHYMFSPDRRVLHVFGYKVDNIKESSAYMSSCWTSFVERGKSKEDLGSMIKQVRQWAEFAVARTAAGGPGEDLRVFDAERFWRTLAFDSGRTAWDIQMPKSWRDMSLERLEDLLKHGTMVDDSPSLSRSSSFAPGPHRRSHPNLHHLSLAPLTPKYPIDPADYSAYFDPSTSELHTITSISQISSLPSPSGILTSHSAAHSRASSRTRQLRKKTRSAISVHDHPAAHPHHAHAHFAGALTSEGFGHKTTTVNASASRPGLPHLHTTDPSWLIQTGLALTEGSRESKGQSWIGKRDSSTSLHSPATPAEERDRDVTNSHHRLYPPSLSSRRSLSRAGRRNSRRSLAVTPALRTPLDEEAMPHWDDDVQTQAEIAAQVESEFADEFEDDPYGLLDFEGQFDSDDEEEVRREISRYRLGRWMDGVVDVFLRLEEFPDSSDTPRDHDVDLEAAGNAVKTELTDSKATTQPKDVDDTSAVSDASIEPPPDKPNGVWDDVVWFGRLLVRTVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZCB4</accession>
    <name>A0A0D1ZCB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arylsulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230888.1">
        <property type="nucleotide sequence ID" value="XM_016385944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZCB4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZCB4"/>
    <dbReference type="GeneID" id="27338719"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11636"/>
    <dbReference type="HOGENOM" id="CLU_018249_0_1_1"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237653" description="Arylsulfotransferase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="73975" checksum="A55C0DED71A9B0FF" modified="2015-04-29" version="1">MKSSLLFAAVSVPWAAAFAFNTYDLGLQGIYPRKRFHSVDFEIPDLKFTQWDSRCDSGNLFFTPRGPYVQGAARGPIITDPRGELVWMNNKKFEQAMNFNVQKYKGQDYLTFWTKQKKKGKHGKPAKGSKKSYVMVRMIPQPVPSLSVFSELKVSNPVTPQLNSSYEVAYRIHPIGKGLKGDSHEFRITPQGTALITIYHKHEADCTDLKLGKSCWIQDGLFQEIDIETGELLFEWRATDHIRMTDVFSSPNMKDGHGKSKADAFDFFHINSVDKTDSGDYVISARYMHAVVCISGKTGEILWQLGGKNNDFTDLNHALDFAWQHHVTWQGNNTLSIFDNHANNVFHKPSSHSKGMIIKLDMDGMTATLVGKYVHPDKILNVSQGSVQIVNETGTVLVGFGNSPTFVEYSPEGEVLCAAHFAPYVVFEIIDFGAVKSYRIFKHPWVGKPKTKPHIKVKSGKVYVSWNGATEVSSWRLEKVIKGAGVEATGKGKGKDKGKDKDKGKGKDKGKNKGKGKDKGKGKDKGEHAEFVTIAEARRSGFETSFDLGNIHGHVRLVALDGARSVMAHSHVVKTPSPSHFFLWSSFILVLCFTGLGILYRRRRHLPHLPNIQNFNLFDLKHRLHSITTTKQAVALSDLDAEASPLLLADREPNMMHLEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHC0</accession>
    <name>A0A0D1ZHC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232548.1">
        <property type="nucleotide sequence ID" value="XM_016383925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHC0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZHC0"/>
    <dbReference type="GeneID" id="27336692"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09609"/>
    <dbReference type="HOGENOM" id="CLU_081915_0_0_1"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27024" checksum="17D33782BC1335FE" modified="2015-04-29" version="1">MSSTATQAMDKLIQRHPLQRIHSPSRGFSAIVHLVGLASFASSYKYLVENPNHINQAYGWHFQYLTIIGLTLATATFALGIAADTTLSRRLFAAKNVLSMCSAPMEVLISVLYWGLRAVDPRLVVPEDLELPVATDLGFHLAPTVLLLLDILLLSPPWTVTAAPAVALSVAIAFAYWFWIEWCYSYNGFYPYPLFEMLEQTQRVGLFTASALIMAANTMILKWLYGRVNGVGKTGVSERPGRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHH0</accession>
    <name>A0A0D1ZHH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232588.1">
        <property type="nucleotide sequence ID" value="XM_016383965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHH0"/>
    <dbReference type="GeneID" id="27336732"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09649"/>
    <dbReference type="HOGENOM" id="CLU_1885793_0_0_1"/>
    <dbReference type="OrthoDB" id="10328141at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="135" mass="14502" checksum="BCFAE819FF296DB9" modified="2015-04-29" version="1">MCFTQYTRDECNDCDTYHERMVTHRPCLKSIRTGQCKRSFDYKTIKRPNEDVDKCAKCLEIRTEAVREATMGEIRVDLTPFWRRMEVAGGGGGAGAGAGAGAGAGAGGAGGDGEAALENTTVPDFAATLITFHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHR3</accession>
    <name>A0A0D1ZHR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232658.1">
        <property type="nucleotide sequence ID" value="XM_016384035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHR3"/>
    <dbReference type="GeneID" id="27336802"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09719"/>
    <dbReference type="HOGENOM" id="CLU_000960_25_2_1"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="596" mass="65357" checksum="D2632117D70A1026" modified="2015-04-29" version="1">MEDYDLEAVDKTPIDVQIEDTSTRYHVDGQIAASVHVEHEIWDGINLKTVLAFLAICGQLSAYEYTLLIPAVAAPYINADLGPDPDYIWINVTWGLGAAILVSVGGRLSDIFGRRYFMLAGALISFLGTIVGATGQSIGQMIASGVMFGIGSGFQEMGFACIMEFIPNKYRLTALGLYGTSAIMCIFAPLITYVFIAHTSITWRGAYWYMCAFHGVAGIFLFCFYRPPSFETKHKTESVSRLSLMKEMDYVGLFLLVAGCTLFLVGLNFGGRRFPWKSAEVIAPIIVGFLCLVLLFVWDFNANLKYPLFPPRLFRQWRGYNVLVLVGFCCGMLYYSMQVIWPRESALLFVPADKPIIRGIYANLTTLATWVSLISVWVFCARFGHEKWQIFGFICCQTAFVGALSTVGIDDKGKAIALVFLMSCFINQPLYMLFSMVSLNLEDQADMGVAVGALSTFRLLGGAVATAIYSSIVDNQFKENLPSQLAKAIAGLNFDQANLKALMVAAASNTAAAYAKVPGITAQIIAASQHAVKLAYVQAFRVVFYTALGFAVLALVSALLVSDIDPARKNLDKAVLLENETVKVVDSKLEPVGQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZL95</accession>
    <name>A0A0D1ZL95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233798.1">
        <property type="nucleotide sequence ID" value="XM_016383095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZL95"/>
    <dbReference type="STRING" id="91928.A0A0D1ZL95"/>
    <dbReference type="GeneID" id="27335854"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08771"/>
    <dbReference type="HOGENOM" id="CLU_036517_0_3_1"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="425" mass="45828" checksum="6B971BD17D19D49D" modified="2015-04-29" version="1">MPSSSTTVDPAIIRALSLEGTSSKITTHGGSGFSSTFRITTSTRKSSTTTAESPSTSIFVKTSSAPGAEVMFQGEHASLNAIHDAVPSLCPEAFAWGRLDLEPGGYFLATEFLDLGGGGGGGRRSGKGKGTGRSGTGSGMSLAEKLAKLHSTPAPVPDGHDEPQFGFPVPTCCGDTEQDNSFTSSWADFFARRRLLAVLDRGEKNNGSPEAQLRRTVERVAGEVVPKLLGDGHLGVSGGRGDGNNSKRGIVPVVVHGDLWSGNQSRGRFVGRRRSRRRLRKQNQGHAPRGHDQEKETDKYASDGDADPDLQAVEEDEYDEEEHEYEDEDDYEEVIYDPASCYAHNEYDFGIMHMFGGFGSAFWNEYHALVPKTEPVGEYDDRVRLYESYHHLNHWAIFGGGGYKGGAMRLLKGLLAKYGGGGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZNK4</accession>
    <name>A0A0D1ZNK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome quality control complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234633.1">
        <property type="nucleotide sequence ID" value="XM_016381531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZNK4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZNK4"/>
    <dbReference type="GeneID" id="27334283"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07200"/>
    <dbReference type="HOGENOM" id="CLU_003612_1_1_1"/>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000003">
        <property type="entry name" value="Zinc knuckle domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="7">
        <location>
            <begin position="548"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="8">
        <location>
            <begin position="957"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="740"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1070"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="740"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="767"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="799"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="851"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="887"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="918"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1070"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1099" mass="121926" checksum="D9C2B05AA36DA2DA" modified="2015-04-29" version="1">MKQRFSSLDVKVIASELAASLVTLRVSNIYDLSSRIFLFKFAKPSKREQLLVDCGFRCHLTSFSRTAATAPSAFVSRLRKYLKSKRVTGVAQIGTDRVIEISFSDGQYRLFLEFFAAGNIIVTDADLNVLALQRQVSEGNEDVDVKLGGKYTLEPKQNYHGIPPITPVRVKESLTKAVERVKAANEAGGKKAKRAKGGDDLRKALTAGFPEFPPHLLEHVFKEIGVDAGLKVEDVLRRPEVLEQILKVLERAKEIFDGFDAGQSKGYIVAKTKTSGVGNLEDQAPGRENLLYDDFHPFRPLQFEENPGIVILEFDGFNHTVDEFFSSIESQKLESRLTEHEETAKKKLQHAKNEHEKRIGALQQQQELHVRKAQTIEANTHRVEEACAAVNGLIGQGMDWVDIGKLIETEQKRGNVVAQMIKLPLKLEENTITLLLNEPGFDEEEESDEEDRTDDEEDSDEETTRTTGKAASDKRLSIDVDLALSPWANARQYYDQKKTAAVKEKKTIESSAKALQSAEQKIERDLKRGLKQEKATLRVARKQFWFEKFWFFVSSDGYLVIGGKDAQQNELLYRRYLKKGDVYVHADLQGASSVIVKNNPKTPDAPIPPSTLSQAGALTVCTSSAWDSKAVMGAWWVNSDQVSKTAPTGEYLTTGGFVIRGRKNLLPPSQLLLGFGLMWLISEESRGNHGKHRLERTESMLSGEAEALAADTQGLSLDDHGDGDDDEFDDKTEDVVPDLEDAAGEGEDEEKQDSQAVDDMDDEAVAEEDKSEAGSEPDEQRSNPLQMNGITDRSAVSADEAEEDPEVQVEVDDEDKAADEKDEQEDTPDAHSPQPPAAVPSQAQPLSKQKPLSRGKRSKAKRAQKKYAEQDEEDRELAMQLLGSNRGQDRKKAAEEEKAAREAKAEADRERRKAQHAKAAERERLRHERLEKAAAEGTADLNEEEELSKEQLEQERRELLDIDRLVPYPQPGDELIAAIPVVAPWTAMPRYKYKIKLQPGSVKKGKAVREILGFWSTLDKKGPKVVDDASKDKERVWRRELDLMKDLRVEEVVGYVPVKGCRIVQGGGIGGGLGGGNAGSKGKGVAGGRGKGGGGKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZU05</accession>
    <name>A0A0D1ZU05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236498.1">
        <property type="nucleotide sequence ID" value="XM_016380671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZU05"/>
    <dbReference type="STRING" id="91928.A0A0D1ZU05"/>
    <dbReference type="GeneID" id="27333416"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06333"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="32"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="550" mass="58882" checksum="3F552C1197F5BE22" modified="2015-04-29" version="1">MLATVEPAKGSELGTVTDAPAHTLNKDLKPRHMQMIAIGGVIGTGLFLGTGGNLANGGPAGLLIAYCLMASLLFSVMVALGEMVSKFPIPGGQFALAGRFVAPELGFAMGWLYWYNYIIVLPAEISAAAVIISYWTPAGDPDSTCTTGICNNAMWVGLMLIVVWAINFAGTRVFGELEFWFASIKVITILGLIIAGIVITSGGGPDHQSIGFRYWHETGGFVQYAGIGRFLGFFSVLISAAFAFIGTEITAIAAAETANPQRSVPRAIKGVWIRLCLFYIISAFIIGLLVSPTDPSLNLSSTAAKSPFVIAMKNAGISALPSVVNAALLTSAWSAGVADLFVSSRTLYGLFSRGHAFQILGKTRGDGLPWVAVLVGVAFSLLSFMAASKGQAGTAFGYFSNMTAICGIISWSGILWTSIRWHKGLKVHGIDRKSLPYRAPLQPYLSYYGLTVCALVLVFGGFGAFIHEFDTSSFITTYFPIPFFAVLLFGYKIVKKSKIVRYEDFDLATGSSDNVSNPVSSTSLADRASTDTDAWQLEQETIWRKIKDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZW42</accession>
    <name>A0A0D1ZW42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_04097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237123.1">
        <property type="nucleotide sequence ID" value="XM_016378446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZW42"/>
    <dbReference type="STRING" id="91928.A0A0D1ZW42"/>
    <dbReference type="GeneID" id="27331180"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04097"/>
    <dbReference type="HOGENOM" id="CLU_051208_0_0_1"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="8">
        <location>
            <begin position="109"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="279" mass="31707" checksum="A9D1D8AECE0EDEA0" modified="2015-04-29" version="1">MPKLGVHKLDVDDAPETTETKSKRRQEAKANVPDAPKTVKEKAQSQEQPGPTSSSSSPPPFPQDAEAKSTLTPEGAPSTATRPLVPPNVLAAYRTPLRHKPKYGIPVAQLQLHSYSVRNLQFYADFCVRAAYYLGLPCSGPAPLPRKRERWTVLRSNFVHKKSQENFERITMKRLITIYDGESSVVETWLAFIRKWQFYGVGLKANVWQWEELDVAGKMDKQFKSLEKDLDDKLSLFGFNKSAAHKTDLLNLMERQKHRQVGVPMSEIREKSRTTQDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZF9</accession>
    <name>A0A0D1ZZF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_02359</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238288.1">
        <property type="nucleotide sequence ID" value="XM_016376718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZF9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZF9"/>
    <dbReference type="GeneID" id="27329442"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02359"/>
    <dbReference type="HOGENOM" id="CLU_023050_0_1_1"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000023">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW18072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="504" mass="56164" checksum="8C62EE8F2A0B18A7" modified="2015-04-29" version="1">MVHIGIPPHYTTSPSSFSHSTSLTINREVALDLDSSNAFEGPEKLLEVWFSPSAHALHRCSEPTGLKAVPAEIWKSMLDLVNCKVLSIVESEDVDAYLLSESSMFVFPHKLILKTCGTTTLLCGLPRILEIATLFGGFARSTAPPSRGIAVAAPPYRVFYSRKNYLFPDRQRGPHRSWRDEVYALDKLFVGGSAYMIGKMNGEHWYLYLTEPYTMLTPPASPQSMDSPGTETKVLDLPTSLTVDRGARVCEGEDETLEVLMTDLDEENAKQFYLDHASAVAEDQWRGSQPSQDDHVDVFSNASSDGDLSMKEEPYPAELTTEGHALGTVVSEACGLSDVYPSHKYPDARVDAYLFTPCGFSANGVIPAPPGETGTHYFTVHVTPEPICSYASFETNVPVGQKGRETTDIIQHVVDIFKPGRFSVTLFEAKTNYEEQSCAGKDELAEIRMFERKVARRNAKMDTIKGYRRVDRIVHDLDGYDLVFRYYERHDWKGGAPRIGERGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A338</accession>
    <name>A0A0D2A338_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239543.1">
        <property type="nucleotide sequence ID" value="XM_016377973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A338"/>
    <dbReference type="GeneID" id="27330704"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03621"/>
    <dbReference type="HOGENOM" id="CLU_027820_0_0_1"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="647" mass="74147" checksum="BDFA27718FD97709" modified="2015-04-29" version="1">MRAIPMRCRKPRYDGSGIIKESYHEDEYFYTGSNLEVLAFFEYASYHRLPIKSRVPKLISHFNKHLHLTFSEKEIEAKLMLFWERGSPAGSARSGWPEIIARGISALRRLPQEKIDRVHKRARELEAVFAHDHNPRGLRRISRPSSAFRTGAKNQRQDVGSLASVEDRRSRRRRKRRDPWTMTRRKNRAVSAPAPSLDSNESQSEEIRDSEEPLSTVKESFDCVLLAKHPRLGDKIEESSQSHQKDDTNPEAAPRPVQHEPQSQTPDSPDQQSVIAMLRLDLEAQRIEKADEVRLWRDLYLEEQRRRKRLSQDLEVLQAALDSGASRKEANLQDKIESLQASLNSSLLVRRFEAPFSWDFQAKNALKISEDFNKIIVILNRVPLHQYNPAFGIDVTKVARPLELVNLLQRAFGRVGDESVIDSSVAELLRQRGLTEVLLSLVGAAICSWVLEPNAGGLFQENHLIYPKLRGLLTALDSRLASSLEFAAHEEFFDDRPMCNLVVSRRARALSRQLIACVLPLVEDHERLGEQYAQIRRGWCEKEDDLTRIFQLALNAKIRLLLTPDLYRCVFPLPGKEVKDRLMKIGLGLVPRHPDPGQKAVTRVSVIPALLRYAAAREDFTYDRFLYNAELIKNIKPDVLIQARVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A6R0</accession>
    <name>A0A0D2A6R0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_01022</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240663.1">
        <property type="nucleotide sequence ID" value="XM_016375387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A6R0"/>
    <dbReference type="STRING" id="91928.A0A0D2A6R0"/>
    <dbReference type="GeneID" id="27328105"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01022"/>
    <dbReference type="HOGENOM" id="CLU_014571_2_0_1"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07627">
        <property type="entry name" value="BAR_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035803">
        <property type="entry name" value="BAR_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="182"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="555"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW20447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="602" mass="65660" checksum="725E1AC11204F01B" modified="2015-04-29" version="1">MDMDSPWDDLDVPSKSHAEAQESTSSTKDSTAPGMTHAAVQDTPADSNAPTGSSTPSKSTTSGPRPSSSRKIPARKIEVQPTKLEAVDDSLDPLGPLGAEPTPATPSIHADQAPTPPRKELSAKVNRPPSAPSPGFPGSEYEDGPLPVGRTKGPPPVQPQAQAPGAVRQTQPSMSVEQAAKPTFDILVGDPHKVGDLTSSHIVYQVRTKTTSKAYKQPEFAVSRRYRDFRWLYNALHNNNPGVVVPPPPEKQAVGRFDSEFVESRRQALERMLNKIAAHPILHHDADLKIFLESEAFNIDVKNKENREPDLGQNNKGMLSSLGINVGGSSGKFVEHDDWFHDRKIYLDALENQLKALLKALDTVVAQRKGLAEAAGDFAVSLNNLAMVELSPIFSGPVQGLADLQSRIRELYERQAQQDILTLGITIDEYIRLIGSVKQAFSQRQKAFHSWHAAESELAKRRSAHEKLLRQGKSQQDKLNEVSAGVSDAEKKAHQARLLFEDMGRLMRGELERFEREKVEDFKSGVETFLEGAVEAQKELIELWETFLLQMDAEEEAAIPPKAQSTASESAATAGPDVSAPPEDSTQGTPATATDVALEQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A6W4</accession>
    <name>A0A0D2A6W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240708.1">
        <property type="nucleotide sequence ID" value="XM_016375432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A6W4"/>
    <dbReference type="GeneID" id="27328150"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01067"/>
    <dbReference type="HOGENOM" id="CLU_003953_5_0_1"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="285"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1179" mass="133856" checksum="07E9ADB12E0DBA3B" modified="2015-04-29" version="1">MEADRSPPLVGHFLELASQWPTARVAVQLIRLTRTTILRYVECPLALEDTSTDGTLKLCSLCLQVDLSIDKFIISKKGLLRNQTFVTDPQGNLTQTKDFQLSSGTSRRVFSTFDQVQEKRNNCHFCDLIWQAVTRYSRRVPDSSTELFLTWEVDGRRIASTNESLVNRTRRIRLSWGGNDGKEENVYLVLVAPTGLRRPNSDAYASSATNTHFLGRGRVDSSEKQALMKSWIDLCAQKHGASCQKKHGTKTEFKKLIEGTFFGVIDVIDMQLKALPLVDGEPERFVALSYVWGKRPNGEHTYTTTRNNVMIHIQHGGLEKAWHKLPKTIQDVILLVSRLGERYVWIDSLCIVQDSLSSWELNAKAMHLVYGNAHFTICAADGEATTGLRAVAPVLRTPVHRAAPTTERVTAVRFSEDTIDRHSDDTMHSEPITAQILPGIKLLVSRPPEAVVQNSLWNQRGWTFQERLLSRRCLIFAEGQVYFQCRSAVMSQDIFNDGGTTGWSLDWTNSPLRTLGELRRRAFWFYMTCIRLYTGRELTKPKDVLTAFQGTSWLLQQHLNAPLFYGLPVSHFDLALLWMPLTVLHRRRQPRIHRSNRGPCSQDELGNCNCKMDEEGDGGKEFPSWSWCGWVGGKAGYQTEMIEGCLLNVREWLRHRTWILWYVRDLEGNLRPLWDKSAFGEDLSEDASWKGYAGNGKSQVQRRARSRSRSRSRSRSRRRMSRVPLSPPSLVSDMHEVNLDGTRHNYMSLPPNVYRPQAPEPSYLAPGVRYPPSYGPPHYYPPTAYPPLAYSYAPYHYETATVPVPVAVPPPVKPHRHGQKEGPRPQSGYEKSEREWVKRGNKDYLRRLPTGYYDHPIDEEGVAERVREPYIVDASGASPVLPFTASIDPGRLQSNDQQGSARTRYPSRRDDRSSDTSSMKTDNSAVVEDLDNTGSERDDASEEGPESDRRRIFIEPNTPRGSPARTAPGGYSDAPVASESSSSGRNMGGSRRRKKGKSSKEDIYGRPRRKGVKRGTEFTGILPDNPFGVIRGPFPKGQKDEIRAMPILQFWTWRTELFVTFREPQTATSTLVNEPCQCDIVDKAGDWCGSIVLPQDWIAERQGVPLLFMAISDARSLTSEECPVWNYYIPKEKDESEWDLYYVLLLNRNRERALWERVGLGKVFQAAFGDAVWDEIKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7J5</accession>
    <name>A0A0D2A7J5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240973.1">
        <property type="nucleotide sequence ID" value="XM_016375697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A7J5"/>
    <dbReference type="STRING" id="91928.A0A0D2A7J5"/>
    <dbReference type="GeneID" id="27328418"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01335"/>
    <dbReference type="HOGENOM" id="CLU_599971_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="381"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="456" mass="52825" checksum="FD1FD1C4275E255F" modified="2015-04-29" version="1">MEEYYPLYFVTFNYDDDLFKFDIDRVDRALECFLDSDLLLSDERDYKNAIEEFIQFSVPEGLGRRLYEHHKRRIKKSFHTGLLVRAKRIKAFRRVLHKVEPQQAPGLKTFTRTVGNLVYKHLPPGVTVAPMEMFAGTVRKLCCKLLPPGVAVSSMEPGFLDDPSWVPVRTSWFVPMCDYYKLIPRSHPRWRPEMPFYPPDIEQAPLLNDLRNWVLDLKELKSVLFRLSTSLSFLLRSFCPRDKHNPDSEHNRVLKLLTYRKHVLSMCGMLPHEDRLVNGRGVDSLEFGLGEVQWHLVKGVWPVFTATEECLILWERSNIDKQKLNVAISRFGRAMIRAEMNDLVNNFRTPHLRKEFQFVVTEDKGPICPEEAIEVGEDDRCPICLEGLKEVGDATTPLVNQSCCNAPPFHLDCLVTEHLKNFAMHKPVKCPVCLVRLSQDELKNVVDKATKHMGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AA03</accession>
    <name>A0A0D2AA03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241793.1">
        <property type="nucleotide sequence ID" value="XM_016376517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AA03"/>
    <dbReference type="STRING" id="91928.A0A0D2AA03"/>
    <dbReference type="GeneID" id="27329240"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02157"/>
    <dbReference type="HOGENOM" id="CLU_055188_5_0_1"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000011">
        <property type="entry name" value="50S ribosomal subunit protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="116"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="314" mass="34598" checksum="E55E0A30DE73380D" modified="2015-04-29" version="1">MPPRLPFRLAVPGAGIDTFLSNSSTSIPSFLLPFLHVQSRQASILSELSDRPGAYNRRIRRGRGPASGHGGKSGRGSDGQKQHGKVPEGFNGGQTPEHIVHGKYGFVNLHATEMTPVNLNKIQSWIDQKRLDPSRPITFLELCRSGLISRPKDGVKLLADGAGELKTPIHIVVSRASQSAIAAVEALGGSVTTRFYTEQAIRRIKKGEMHPFVSLRWDPEALNKPALLAAGGQTLEERVAGMGYEYRLPDPTSRKDIEYYRDAKNRGYLSHTVKEGEGPSLYFKPPISEEQLKELKKARARSGTAKAKEENKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AA33</accession>
    <name>A0A0D2AA33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241828.1">
        <property type="nucleotide sequence ID" value="XM_016376552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AA33"/>
    <dbReference type="STRING" id="91928.A0A0D2AA33"/>
    <dbReference type="GeneID" id="27329275"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02192"/>
    <dbReference type="HOGENOM" id="CLU_020336_49_0_1"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF46">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="312" mass="33893" checksum="808E77A703830503" modified="2015-04-29" version="1">MTTSEVTLPDGRILAYIDYDPPTASGDGGHATAASPAKPVLFYCHGFPGSRVEGDFLKSTAQRHGARLISIDRPGMGLSTFQPHRTVLDWPQDVLHLANHLHIDGFYVVGASGGAPYVFACVKALPKTRLLGACVVAGAYPLSLGTDGMSWPNRILMWTASSKWFSWVSSLLMDLEFGSVARDREHPERMTKMMVQVMKSRPGPDAKCVDSEWATAKLVEALQESYRQPGDGVNLDIKLIAGDWGFNLADLDTEGFNISLWHGGLDANVPVGMARKGAALIKGAKLRVLEDEAHLSISMNAQDQFLETLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT17</accession>
    <name>A0A0D2AT17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_12104</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847513">
        <property type="protein sequence ID" value="KIW09645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229861.1">
        <property type="nucleotide sequence ID" value="XM_016386411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT17"/>
    <dbReference type="STRING" id="91928.A0A0D2AT17"/>
    <dbReference type="GeneID" id="27339187"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12104"/>
    <dbReference type="HOGENOM" id="CLU_642554_0_0_1"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW09645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="427" mass="47469" checksum="AE6D179649E31A35" modified="2015-04-29" version="1">MTNSLTVLSDRTKLRECSSFLRTARVVVVTGAGISRSCGIPDFRSPGGLFSQTAEEAISTLGQPGQCGFPDDFAVVSVARGVSGKDLFQVDLLRTVRGWTVFMQFTAALYTRLGALEEASATHWFLRCLHDRGQLIRCYTQNIDGLEARVGLSTELTEQTVSGADGMTRCPIIQLHGDVRFVRCTICDHRSSWTDEARLAALKGDTSITCPRCLDERHNKRRALGKRVWACGSLRPDILLYGETHSNDVLLQLAQENDDGLRPTALLIMGSALRVPGCKDLVKRFANMVSKQNGRVISVNPTRPSPSLWGQIIDDHFSMECDDWVGIIQDHWADDGDTALGDRDIQSLRVAAATSKGRGGRKKERNRSRGRKESMELETPAAETMPKTLAEEKTAKASTIEDDSLPTTYRQRWRMDMKYLKEQFDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATP7</accession>
    <name>A0A0D2ATP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_11986</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230101.1">
        <property type="nucleotide sequence ID" value="XM_016386293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATP7"/>
    <dbReference type="STRING" id="91928.A0A0D2ATP7"/>
    <dbReference type="GeneID" id="27339069"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11986"/>
    <dbReference type="HOGENOM" id="CLU_147541_0_0_1"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.49.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW09885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="119" mass="13828" checksum="286EBD90197EE5FF" modified="2015-04-29" version="1">MPGYAKASSCCYIYERSGLTLLFTIFKLFSTTKQLFPRSIAKMNAQSLLRARMATQTIARRGFSTTRPRFDSPFHYPEGPRSGLPFNPKTKFFWLRYWTFMTAGFGVPFLMAIWHTYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUA3</accession>
    <name>A0A0D2AUA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230241.1">
        <property type="nucleotide sequence ID" value="XM_016386109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUA3"/>
    <dbReference type="STRING" id="91928.A0A0D2AUA3"/>
    <dbReference type="GeneID" id="27338884"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11801"/>
    <dbReference type="HOGENOM" id="CLU_043194_0_0_1"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="39451" checksum="C3288391DE93D36E" modified="2015-04-29" version="1">MSEESKASAEPDPLNNAHASLRSKRFRFKSARDEGSGGDGDMRSHKRRRPHDSSNRSRKRYRSSRHRSNTPPRHQSSSALPPDQAFRESLFDALGDDEGAAFWEGVYGQPVHTYPNTYEDEETGELERMTDEEYAQFVRRKMWEKSWEGIEAAKQENRRQREKEKQKLREEDAKQRTQREAHYDDFSFDTQIEASLRRGQKRKDHKRWKALWQDYLKKWDEMYSLAQNRPKTEDDAEQVFLRNKIAWPVESGKREDVNGDEVERFIRKGTTSLDPDESTGDLFANVIKAERVRWHPDKIQQRYGFMTIDESTLKAVTAVFQIIDTIWNSIRTQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUT3</accession>
    <name>A0A0D2AUT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230699.1">
        <property type="nucleotide sequence ID" value="XM_016385755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUT3"/>
    <dbReference type="GeneID" id="27338530"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11447"/>
    <dbReference type="HOGENOM" id="CLU_008455_1_1_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW10483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="477" mass="52011" checksum="BCA5A6AA4FDAB584" modified="2015-04-29" version="1">MEEGKIVELIPPTNDLIVDWTGDDDPENPLNWSSKRKGINIALLSCLTFVTPLASSMFAPGIPLVMKDFHSSSIFYATFAVSIYLVGYSFGPLVFAPLSELYGRLPVYLATNVLFVIFTIACAVAPSLGSLIGFRFLAGSAGSAPLVLGGGSVADLYPREKRGSKMAIFSIGPLIGPVAGPVAGAFLAEDVGWRWVFWVITMAASIVVIACFIFMRETYAPVLLERKAARLRKSTGNQCLRSKMSTDDSPRNAIAKAFIRPTKMFFMSPVVFVFVVYISVIYGYLYLLFTTITEIYESVYHFSTGLAGLSYLGIGVGMFIGLGAFGATSDRRIQKKKAHGDVSPEIRLEGLIPAAICIPIGLFWYGWSAEKQIHWIMPIIGTGWVGVGLIGIFLAVQTYLVDCYPLYAASVTAANTVVRSLVGAFLPLAGRPLYSKLKLGWGNSVLAFIALAMVPLPFIFMRYGARLRTHPRFQVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVB7</accession>
    <name>A0A0D2AVB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Purine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_11632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230884.1">
        <property type="nucleotide sequence ID" value="XM_016385940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVB7"/>
    <dbReference type="STRING" id="91928.A0A0D2AVB7"/>
    <dbReference type="GeneID" id="27338715"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11632"/>
    <dbReference type="HOGENOM" id="CLU_017959_7_0_1"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW10668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="63600" checksum="C2327969734CB0BE" modified="2015-04-29" version="1">MEQKIAAEENKMAVDSSTTSTYEAAASGTAAKVSFRDKATDILSQLGTRDAWLGDYDYWYLVTPNIPPFNRKYKHKTMPFYGLHDRVPILLTLILGLQHALIMIGSVASPPLAVASGAFHLEQAQVSYLVSAAFITTGIATAFQVTRVHLKGTPFYIGTGLLSVVGPTFDIIPIAFSYTSMRYNNGTCPTADDGTQLPCPDAWGAFLGTMLCTVLIQILMSLVPPSLLNKIFPKVVTGSLLLLVGVYLVGNGMQNWGGSSNCNGGEGFYALCPSVAAPKPLPWADPKLIGLGFSVFVSIVIVEQFGAPIMKSMSVLLGLAVGCAISGATGYWSRENIDSAPVVTFLWVHTFKLSVDGALVLPLLIMFICQGVSCMPDILATAEISNVDVEGTEFNSRIQGGILCDGLGSLFSALGTAGPMVSQAGNNGVIVLTGCASRRAGWAASFFLVLMGFFAKFGAVFSAMPPSVLGGMQVFLYSTIVVAGIRILGMIQFTRRNRFILTIALGIGFIDIVQPKWFSQILDYSGSNVNLQGFEQGINLVVETPFIIAAVIGVFLNLVFPNDKSEMDEIMYGTTTDSRGAPTSLPQMEHRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AX09</accession>
    <name>A0A0D2AX09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231459.1">
        <property type="nucleotide sequence ID" value="XM_016384857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AX09"/>
    <dbReference type="GeneID" id="27337626"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10543"/>
    <dbReference type="HOGENOM" id="CLU_032227_1_0_1"/>
    <dbReference type="OrthoDB" id="3469225at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="269" mass="30517" checksum="EB3B6B500C08F023" modified="2015-04-29" version="1">MPEQADQPSYFSLWNFVKQRNAALSSMSQLTMESPLRNDLPLYPSLPFSIKVCESLSKVSSAFNDMAIAGQLSIQMIGIIATLSTMMKNESGGSLGLGSPSTSSPASSGPNSPSERNLLHIIADLRCLSMLGTVPIEHLLCHGLIGFCLRLHFREEKLGDDFDEIIQGLEDTLVGRGKPRPQQDLEKFYKEHKDCLLWIAFAAADALEMSPPFSRKSMVLEQTLDRYPTETSRWETLDKILRRFLWNDFLAQHWKRRWEVATRRRLKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXB6</accession>
    <name>A0A0D2AXB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_10339</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17 18">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231256.1">
        <property type="nucleotide sequence ID" value="XM_016384654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXB6"/>
    <dbReference type="STRING" id="91928.A0A0D2AXB6"/>
    <dbReference type="GeneID" id="27337422"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10339"/>
    <dbReference type="HOGENOM" id="CLU_049327_0_0_1"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000016">
        <property type="entry name" value="Putative ubiquitin thioesterase otu1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBX" evidence="13">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="OTU" evidence="14">
        <location>
            <begin position="162"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="79"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW11040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="360" mass="39707" checksum="47370280156F0D50" modified="2015-04-29" version="1">MRVRLRGPSGKSTTVTLDDTATVESLRNTVTAETSLSSFEIKYGYPPKTLMLDQYPPNKLLSELDVKLSGEQLIINSTEAASRKTTTEPSQTFQHSEKDNHSSGRVAELPTSHTGSSHSSSTKEQNREVKKASSAPLSLTRKENKAMSDPPEIFLPDLGGSLVLRIMPDDNSCLFRAVASAIMSNLDTMTELRSVVAQTIQANPDKYTKAILDNKDPDAYCRWIQTENAWGGQIELDILSQQFDVEICSIDVQTLRVDRYNEGAPRRCFLVYSGIHYDIIALSLFGMPPEDDVKQFEQPLSDEVLPQAVALCQKLQEKHYFTDTAGFRLRCGDCGATCIGEAGATEHAQATGHYNFGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXX5</accession>
    <name>A0A0D2AXX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphotyrosine protein phosphatase I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_10819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231734.1">
        <property type="nucleotide sequence ID" value="XM_016385132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXX5"/>
    <dbReference type="STRING" id="91928.A0A0D2AXX5"/>
    <dbReference type="GeneID" id="27337902"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10819"/>
    <dbReference type="HOGENOM" id="CLU_071415_2_0_1"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000105">
        <property type="entry name" value="Low molecular weight phosphotyrosine protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="9">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="169" mass="19077" checksum="803C82DFA73C544E" modified="2015-04-29" version="1">MTDKLSVLFVCLGNICRSTMAEGVFRSLTKSHPLIGDIDSAGTGAYHVGDSPDDRTMETLRRHGISDYDHGARQVSVQDFFDYDYIFAMDAYNLRDLQRLQRRAESKGKTDPVRANVMMFGEFHGTGRQGKAEEVVDPYYGADNGFEVVYEQVARFTKNFLEQVVDKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AY61</accession>
    <name>A0A0D2AY61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_10660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231576.1">
        <property type="nucleotide sequence ID" value="XM_016384974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AY61"/>
    <dbReference type="STRING" id="91928.A0A0D2AY61"/>
    <dbReference type="GeneID" id="27337743"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10660"/>
    <dbReference type="HOGENOM" id="CLU_080773_1_1_1"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="67"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW11360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="235" mass="27749" checksum="F319D857076E9130" modified="2015-04-29" version="1">MVQMGKSAFISTCTSHSHDPKRNIPLRERRPNGNDNSDSRQHIRDEEEFHYLVYSADHEEEDRISRLQEYQVIGRHLPTDANPTPKLYRMRIFAPNTVVAKSRFWYFLMKLRKVKKSNGEIVSLNVIHEKRPLKVKNFGIWIRYDSRSGTHNMYKEYREMSRTDAVEALYQDMAARHRARFRSIHILKVVEVANPNDVKRPYIKQLISKNLKFPLPHRSTGSKKLFVPNRPSTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYV1</accession>
    <name>A0A0D2AYV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_10912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231826.1">
        <property type="nucleotide sequence ID" value="XM_016385224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYV1"/>
    <dbReference type="GeneID" id="27337995"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10912"/>
    <dbReference type="HOGENOM" id="CLU_131535_2_0_1"/>
    <dbReference type="OrthoDB" id="4113071at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16495" checksum="711310767A379E0E" modified="2015-04-29" version="1">MGLVEIKLVDLAEPARLLPEDKPVVLVNLIKFKAQATYPEGSPHTAIPGREAYYTRYVATFSEISASLASTPDDKFKPLYLGNVVANMLAKPYGGDESFDMVGIIQYRNFGAFRKVIESKEYEERALPHRLASIEDYRLYVATEMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZC5</accession>
    <name>A0A0D2AZC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Suppressor of anucleate metulae protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_09272</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232214.1">
        <property type="nucleotide sequence ID" value="XM_016383591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZC5"/>
    <dbReference type="GeneID" id="27336355"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09272"/>
    <dbReference type="HOGENOM" id="CLU_014851_0_0_1"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000003">
        <property type="entry name" value="MYND-type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0749">Sporulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="13">
        <location>
            <begin position="570"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="174"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="282"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW11998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="624" mass="69995" checksum="42C3C45F1B9AAD8D" modified="2015-04-29" version="1">MREVNFSIPNVNKASVHITPTLYDRRALDCTSTLPLINSLNHLAYLTTSSARIRDILTVDGGVERLVCILKEGRSKDEMHMWKWNLAFQCIVNIGVRGSEVVRTRVVEADMVPVIATILWDYILVIEMEKAKVDAEQEKRNGSRHGGSSRSKISRELAQDPLSRTSFLEHMNAAADQRSTRRQAPPPSLDLPQSFSQSFGATETGPADSNAVPPGVFTSPPERTVFPRRDFHHHVRGQDSRGSFHRSMNLQPPATAVPAMDATDGFSLRPVREVDRLPSMLPALNTGVTSHPDSPTTPSAPISRGPLSPAGRRIRRPSIRHQNSTSADPDDVMLDDVAAPGEDLLDVDGQPGGQSRTQTRDPSPHDPEGLPERQSLSLTIPPQQLREIDNVDIAQQTPIVAGMTNPLGPAAHEPMGASPIPPPPATAASPAIPLNAYPNFFLRTATATASTTALMPRDEDVLMGLQLLAYISKYCYLRHYFQKTHLVPRLRIDREVEKIYGPMRGCPVLPEPTEDEDEEFLQPDDYNIFPLVEKFTVRHHSKDMQYWACVVMRNLCRKDDARGGIRQCANYQCGKWEEYTRQFAKCRRCRRTKYCSKECQRESWSMHRHWCHLENVYLSRRAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZQ9</accession>
    <name>A0A0D2AZQ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232434.1">
        <property type="nucleotide sequence ID" value="XM_016383811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZQ9"/>
    <dbReference type="STRING" id="91928.A0A0D2AZQ9"/>
    <dbReference type="GeneID" id="27336577"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09494"/>
    <dbReference type="HOGENOM" id="CLU_1427999_0_0_1"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="190" mass="20074" checksum="D3E17B67C979F07F" modified="2015-04-29" version="1">MGHGRSDSPHLPGSAQQHQDDAKSGIAIVISSSISKGLLNLTLDSDSASRHRLSDHLCELDRLPHARVARADACAAKAGVNAISDVSSLENGAQGVTSILIVPGAIAGTEGTDRLVAIYARKESWRNIPQQRFGLVREIADATVFLFGDTAQFINGICLDVDGRTWRLKAGGQFGQNLARVCTSGREAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0V7</accession>
    <name>A0A0D2B0V7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232724.1">
        <property type="nucleotide sequence ID" value="XM_016384101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0V7"/>
    <dbReference type="STRING" id="91928.A0A0D2B0V7"/>
    <dbReference type="GeneID" id="27336868"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09785"/>
    <dbReference type="HOGENOM" id="CLU_028343_1_0_1"/>
    <dbReference type="OrthoDB" id="4154542at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="66732" checksum="5355A403F4A4DD7F" modified="2015-04-29" version="1">MAPQFLFVNKDAASASLTRSNALEQTSINSHVQRGRRHKRSAHNKGRAANQGRSANNPGRKGDGDDEPDLGSSSAKAASASASSLPEGETSQSGVKIPTSPSSRSKPKSKNARITASGKARPKVQFNKRSDRGQSPQNVKSPKNSDRAILLLNPSSPLNSPRDISQVTSTSIDPFGHSVVKMDPHVAELCRYFRDKFHPSVWHAESWTLKGQYTHQSTSGAIIQRAMQNEVEMNAILACMAARIENVDLIPGQQTDRFMGNALFAVRKRFSSLNAASKHQLLLIIFHLYAGEAYRQNWQAARIHMRAAKDMFNSWGGLAHVPDQSIRESFIIGDGNVSACLMEPCELPCEYDPGPYFTVTPPEMLLEAPRDLSTIAPAFQGILADGYLPDDLVEILLETVECAWVLRYARTGTSPQAAKHAARWLLWRNSAVRYRILAIKYTDMVHEAIRTALFIWIVTAMVVPLGVMRIADLNAPRLMRALQSAKWPTHEWKGLLEIKMWVLAIGAQAARLDSYEEKWYLDQLFEVGLPEKIRRFREHNPDFETVDVLKQFHQRFFYYEPIQQARLQRLAHLIGGRVDFGSRSPSDRTSKSRSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1F4</accession>
    <name>A0A0D2B1F4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_07944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016382271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1F4"/>
    <dbReference type="STRING" id="91928.A0A0D2B1F4"/>
    <dbReference type="GeneID" id="27335027"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07944"/>
    <dbReference type="HOGENOM" id="CLU_129387_0_0_1"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="145" mass="16127" checksum="A65B2A9B67BD6920" modified="2015-04-29" version="1">MSALLANKPLLGPLVALNAWTLGMEALLYKRRTPALAKYNITFDPETVKKQKAEKLPAFVQWPADNYNNLLEQPTQFYAILLGLTLLGVKDRRTVGLAWAYVGLRFIHSIIHVSTNKVVVRFAVFAASSFALLGLTAETAWKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B321</accession>
    <name>A0A0D2B321_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016382841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B321"/>
    <dbReference type="GeneID" id="27335599"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08516"/>
    <dbReference type="HOGENOM" id="CLU_088298_1_0_1"/>
    <dbReference type="OrthoDB" id="9981319at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="169" mass="19784" checksum="CFF68AD818CB4DCD" modified="2015-04-29" version="1">MPIYEFHHILPLSPIQKSRLARVVTDWHSFTFRAPRFIVNCRFVDTRSVPSEDNYVGGKPFKSNRLFVSLRSGTGRTEEQYIDMTRKLQAMWNETVQDVPAPSVEKELKDVFIMGTLDSAFERGWFLPMPGKFENWVKEHTPDFQKLAESGDPVFKDLLEEIKERPEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B396</accession>
    <name>A0A0D2B396_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233599.1">
        <property type="nucleotide sequence ID" value="XM_016382896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B396"/>
    <dbReference type="STRING" id="91928.A0A0D2B396"/>
    <dbReference type="GeneID" id="27335654"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08571"/>
    <dbReference type="HOGENOM" id="CLU_058869_0_0_1"/>
    <dbReference type="OrthoDB" id="5385910at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="302" mass="31812" checksum="CD141DCE27C942B0" modified="2015-04-29" version="1">MAPIPVHTASPINKNVPSDTLPDTSPSAAALRYTPPANAEARPTTTTTTQQQQRGSSYYPAARPGAAAVPQSTNAASATYNGRLQPTLMAETTTSTTLTPTPTRTTATKAPSSNDDNSPPSPQPGAVPSAAADYTLTPTTLSLPQPPPMPMPVPGPQPHPHAQHAPSPSSPSLMTQSSSPVRRHALPSPTPTRTSYPVVPFPSAYPPPGQQDLSHPPGYVQDSRASFDDKPVEECQPYENRASPSSSSSSAGRRGILDSEPVFDSRAESDSLLNTAMSWAKAAGKRLSKTEQEIWRHVNGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4U1</accession>
    <name>A0A0D2B4U1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234149.1">
        <property type="nucleotide sequence ID" value="XM_016381047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4U1"/>
    <dbReference type="STRING" id="91928.A0A0D2B4U1"/>
    <dbReference type="GeneID" id="27333797"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06714"/>
    <dbReference type="HOGENOM" id="CLU_079179_0_0_1"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW13933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27090" checksum="223255198FD5E5B8" modified="2015-04-29" version="1">MSSDTAMTTAAASSTAPTAHVDPAIFTSLQTKIDEESSIRDELKAYVDTLTKQGRLTQSILSRIHNTPTSELERSVLNPAYDALAQQASTVKELAQSASKYPFYKWNSLWRNDVQSVIGSIQIADWLQLGQLATIEQVGERLGVPVNLKDEDKFHITIEDYLLALTTTIEELARLAPNAVTLGDYARPLQISKFIKDVHAGFQLLNLKNDILRRRTDGIKYSVKKVEDVVYDLSLRGLIPKDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B771</accession>
    <name>A0A0D2B771_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calcium/proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_07568</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234999.1">
        <property type="nucleotide sequence ID" value="XM_016381897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B771"/>
    <dbReference type="STRING" id="91928.A0A0D2B771"/>
    <dbReference type="GeneID" id="27334651"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07568"/>
    <dbReference type="HOGENOM" id="CLU_008721_4_0_1"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="231"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="470"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW14783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="614" mass="67919" checksum="CF6AC57837864F7B" modified="2015-04-29" version="1">MHKFRREAKHAAWYSDDGPRRNPFGRWRPPDRANTLQSVSPGSAAPLRIVQTDHSNHYRRSSGQSHAILPASERPSHGIAPSTLEASHTEAEIQRTSSPEHYFSEHEERTDNPANPETPAVQEIDPEKPGVRESPSPSSKVENQDEEGGGEPSTDILHPRRAAQKLNPDSQLQKEADKEKESDHHNGREEAVQVFSTWSQIRATVFGSWINVLFLLVPVGFALNYANVDAAAVFAINFVAIIPSTLMISFAVDQITFRLGELQGALLSITFSNATQLISSVLLLKHKQMTILKTSLLGSIISNLLFMTGLCFFFGGINRIEQTFNVTVAQTVSMMLLLAVISLVVPTASRLMVAGITDHDIVVQSRGTSIMILVSYALYLLFQLKMHRRLFDKPSERPRKVAIKKSTRVVVPDKLRPSPPVAAARREQIEDSPEDEYREEEDGGGNDDDDDDDDVEAEEEETPVLSFLAAFVTLIVSTVLVAFNADFAIGSVQKMVRQAGVSQTFVGFVIFPLLSNDPESIFLAARNKLYLSISLTLDKCMQVALLIVPLLVMIAWAMANEEMTLDFDGFPVVVSFAFVIVVAYVVQEGKSNWLTGALLVKVYVIVALATYCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7K5</accession>
    <name>A0A0D2B7K5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234881.1">
        <property type="nucleotide sequence ID" value="XM_016381779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7K5"/>
    <dbReference type="STRING" id="91928.A0A0D2B7K5"/>
    <dbReference type="GeneID" id="27334532"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07449"/>
    <dbReference type="HOGENOM" id="CLU_046550_10_2_1"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="30"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="396" mass="43311" checksum="08A7A9C9187A5643" modified="2015-04-29" version="1">MASSKLLPLKSIPTLSDLYRAELLAPSAEEDLASPNQEYNDKISLIQHDITLLEVDAIVNAANRRLLGGGGVDGAIHRAAGPGLLKECATLDGCATGSAKITDAYNLPCKKVIHAVGPIFDSITKSEPLLRSCYRTAFRLAAQNDCKSIAFPAISCGVYGFPSKPAALAAIRETLAFLKTPAASGIERIIFCNFMDRDVDAYADLLPLIFPPTLEDLSPTSESDLSDLTDSDDDEGQPSPMRPIPPRTLYVNPRVDRNSGSRSASFRSSSKRSFEELFEDDDEEDESPVTKKRRAGSGPFDCEGGDEQDQSLREGAESESEDEVDTKIPTTVWKGRLTDPVDDECPHERFYVADGLSSHGLWPHGAWICECGEKFLQRCCTDMPAIGRGVYHRYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9G9</accession>
    <name>A0A0D2B9G9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235799.1">
        <property type="nucleotide sequence ID" value="XM_016379972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9G9"/>
    <dbReference type="STRING" id="91928.A0A0D2B9G9"/>
    <dbReference type="GeneID" id="27332714"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05631"/>
    <dbReference type="HOGENOM" id="CLU_025898_1_0_1"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="11"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="519" mass="57801" checksum="4459AF579C274DE8" modified="2015-04-29" version="1">MPLNTLRLNHQKSSHPNDRVVFIKPLPRPAAQKADYDLADTFLRAVAAQCLPIMKNHYLSVTTLEEYEPNPEFIGRNFNNGEIIQLVLRSKNGGWVPFNMVQMVMMHELAHNTHMNHGKKFWETRNIYAEELKQLWARGYTGEGFWGSGRTLNDMNSVMGNNILTSRELEGLPLCGGTYRSRGARRKRKAKRGGQEELTWKEKKERRIERKFGRNGVALGEDEDKRLGLEINRKGPIGGKPRVAQSKRGRELRAAAALARLDTNKQEVGALKGSRDESGEGQSTEVDEEEEEEEEEDYEDVDAAEGEDAKDVNGEKMLDGQGRGLVRVCEEEDKNDENVQNELRELEGLERYFRRRPKQSQSGTVAGPSQAASSEHAQNKPPGEHLIAGNGCGGGGGCDDDDDLTKKPHPVSHAEPTPAKEASHSTPAIENARERRGERRNQHREHGTSTPSATISCPICSLENPRVNATCVACAHVLDPRKDPRHWSCRSEICKEGDNRYLNAGDAGVCGICGMRKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAV3</accession>
    <name>A0A0D2BAV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236314.1">
        <property type="nucleotide sequence ID" value="XM_016380487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAV3"/>
    <dbReference type="GeneID" id="27333232"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06149"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="64"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="523" mass="56735" checksum="34FDDBE487ACB749" modified="2015-04-29" version="1">MTSQPFAASSIGLDNMKLPSDLEQISGLTVQQTKAGFPTLVVSFEGPNDPMNAQNWSASKKLRNFLAYSYPCFVTSFSSGALSPATGQIAKDFHVSPEVALLSTTTLFLLGYTGGPFVWGPSSDYYGRKIPMMISVFGALCFGAGASSAKDYQTLSLCRFFQGAFGSCGIVIPMAAFADMLNPEFCGYAAIVFVFIVLSGPLIASPISGFTVDNDSLNWRWCSWWTVFANALALVCMSSVVESYTPYLLQQKALKLRHTTGEFSIHAPLDENKRSLKQVLKMLATLPFIMGAKEPILALISIYLAFVYALVYVFLISYDLVFIDGYHMSSGVGGLTLLSLVLGCGLGVAASILDQRRMFHKMASNGGLMIPEWRMPLCSAGAVAFALGLFFFGWTGAYPDHIHWIVPVTSGLVTGFGLLVISYCMFSFIIDVYKINSGPALAMNAIVRSSLGAGFPLFARQMFENLGIQYASTLLGCLAAVMIPVPFAFWRWGPRIRARSTFAMASPPSDAIKAENRGMRADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BB00</accession>
    <name>A0A0D2BB00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236389.1">
        <property type="nucleotide sequence ID" value="XM_016380562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BB00"/>
    <dbReference type="STRING" id="91928.A0A0D2BB00"/>
    <dbReference type="GeneID" id="27333307"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06224"/>
    <dbReference type="HOGENOM" id="CLU_016010_0_0_1"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="407"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="877" mass="96692" checksum="86F905B0F8FD3EDA" modified="2015-04-29" version="1">MEQWAVKDPPRRFLIGKKNSSEDAQKPARLPLSSRLETVTRPISGLARHRIHQLSEIREVSGSSKATSAANVHSEWTDGANDTPQNRPLPPKDALSQTPSSEFLPPTPIHPTPRNFTALGDRAASAISLPRKCVPERRSSASIFSPGLAVSKPNSLQELPTWKVSELDGSSQIIPNRGRAESPVRRAINQSAQSAEIFRPSLTRTFIRTSPPHEILDNGSIRHPRVDLSIRLPSPLFVGGGTVEGHMSIEVDGGAPRKPKWKPIYISKASVDVIGVEEISDGRRWVFLSLATELFDRENPPPPSLVTSQQPAESPETWWELKSAKANIPFSVNLPLKLGPPPYASKQASIRYMLCPSIVIRIGDKRSTVRQTWSIQMLTIHDPEKALASLPSPLLAADTLYLAKEPDIQTVKLTAGLHRQTWVNGAKIFVDVHVANNTAKTVRKIQVQLEKTTLWYTHAPAGTFEKSATHLRLPKRTDTDTVSSTTFKMADSWQGVPSYSSDVRTVELEAPRGHVTVSTGRYFEVRYFVNIIVTVKRSKTVAVQLPVTIIPINSLDILPNSLAQVAASIEAKRARTVPVPSSVPTPAAYFQGQAFVVPVRRSVENPRSEADVPSFVDMENLKTDIDNSPRRVHVHGHCMGGLQADTTDENADPSRPSLNPSSHHHVTKRPSCYHCHLVAGPGASPVRGGPRLPRLQVSTSGLGFSESEFDVPADSPPRKVMLSERERNMINQQRELRIREDRGERKPSRPSKEIKRGEEPRRPSKEQPPRYNNVVADSNAEPKHLPFGNFSPEGPSSYVGSTRVSMSDIHTNKAGPGRSRSKTNPEGRPRVLSSGKPRETPGIDRSKRHAYAPSSSGLGHRRMSKDNGYRASIDQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BC16</accession>
    <name>A0A0D2BC16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450 oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_06221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236386.1">
        <property type="nucleotide sequence ID" value="XM_016380559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BC16"/>
    <dbReference type="STRING" id="91928.A0A0D2BC16"/>
    <dbReference type="GeneID" id="27333304"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06221"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW16170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="57136" checksum="8A4DF89B7747D3F3" modified="2015-04-29" version="1">MLESIFPVIADNWPIAVSILLVGYLLSNYFNHGLNKYPGPFLAKFTNWWRFFDVYGRRPDITHLKLHRELGDVVRLGPNSLSFSNPRALKTIYGLNKGFIKSDFYPVQQAVKDGKRLPSLFSTTDEAFHANLRRSVNNAFAMSQLVQYEPGVNETIEIFLDQTDKLYAKPNRRCDFAEWLQFFAFDVIGQITYSKRHGFLERNEDVDGMIRYLGKLFSYVAPVGQMPWIDLLFLKNPLVLLADKLGVKLFAFPITKFALARMNERLTEIKDQGREKGTNRPDLLSMFLKAQTDRPDFMTDQRVLTMAVSMAFAGSETTAISLAAVFYYLLRNPRCYDKIMAELDDAVKEGRIENRPSGTVSWAESQNLPYLDACIKEAFRMHPAPGLPMERVTPAQGIEIDGHFIPGGTIVGCNAWVIHKREEIFGAQVDSYIPERWLDASKGQVKEMNGTLFQFGAGARTCIGKNISLLEMYKLVPSFLRRFEIRFDDPSRDWKLHNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCN5</accession>
    <name>A0A0D2BCN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236596.1">
        <property type="nucleotide sequence ID" value="XM_016380769.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BCN5"/>
    <dbReference type="GeneID" id="27333514"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06431"/>
    <dbReference type="HOGENOM" id="CLU_001250_0_0_1"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="7">
        <location>
            <begin position="183"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="8">
        <location>
            <begin position="487"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="6">
        <location>
            <begin position="1068"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="939"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1699"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1820"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="417"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="571"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="700"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="911"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="970"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1253"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1312"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1386"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1458"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1525"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1701"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1715"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1846"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1880"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1940"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1978"/>
            <end position="1987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="2030" mass="227842" checksum="DECFD18EA0F8B847" modified="2015-04-29" version="1">MAEDIDVRAISAFSSLPENTITTLRQTPSPELIDEILRAFLPRIKECEQTKAKQVKTEIELETYTRKNDSKVKALSESRDKALEQAGKLRGELQIAETAKTRLETEIDQMRSATANENSEISTLKSRVTSLEAANRDTLALLESKTTAYESLSQELAAQHQKAAELRKQIATLEQSVQSANASVASAKFKEQSLLQEVDMLKKNNEWLENERKIKADEHTNFRKEKNARISELSRSNEQYIAEAEALRRSETALKHRLEEQATKLEETLEEIQKIREEKISSDESHRVELESVTRLADLQAASAETAKQRVQELSAALEEAREEAAEEVGTIRAEIESEHNDRVAAEQRIAELERSLEELSNELEQARARPSTPQRAMNGSGITTPIRAGTPGGIFSPSSISRPRTQMTMTQLYNEYTKLEGDLASERRANEQLRENLDAMVEELENNKPEIEELRMDHDRLQSEVVEMSSIMDKANAERDSAVKELKHCQGQLESKSREVEVLTQQLRDTGSQIRFLLIEQHVREQGGSLTREDFDDLERQANEAMAQDMANLSETQQLVNQRLIVFKNIDELQRQNQDQLKTIRNLVSELESSVAKEKEQQQLAMKEELEQARAQISSYQDELKTMVAQTKSFVKERDMFRNMLTRRGHLAAGQVHPTDFSRSLPVPNGESPAPSVAGGESDYAKLLKDLQHHFDTYRQEASTDHSALKTQVDELSRKNSQLQTEISRAMGQLTAANQRYEMLQANYNSLKTENGEIQKRSYAVMDNANKQEVKAQQVAEELVEARALVESLQRDSANLKAEKDLWKTVERRLIEDNESLRNERGRLDQLNASLQSIINEREQTDAESRRRLQSQAETLETELQSVKRKLNDEIEESKKASLRREYEHEQSQKRIDDLVTTLGTTKEELASAKTARDHLQARVDELSVELRSAEERLEVLTRPAEPAAQENGTEESSLTKEQELSVEISELKRDLDLKVSELERANEQVEVYKNISQSSEERLQELSETNDQYREETEAVLAEKDGKIKDLEQRIEDISSELNTTNSELSKLRDEQADAGRKLHEQKAGFEAEIERLKEEAEKSAEQAQFNLEASKVQAQIATEAQQNYENELVRHADAAKALHTVREEANQIKLEAVDLRTQAATAKADLEQKEASWNELKDRYEREVSDLKQRREEVMQQNTLLHNQLERLTQQISTLQRDRAALAEGENAEGPTQASAELDESQEMIRYLRREKEIIEVQHHISVQESKRLRQQLELAQSQLDDTRLKLDQQRRAEVDAERNAINHNKLMETLNELNLYRESSVTLRAELKQAKDSLAERSKRVEELEGKIHTLNTRVAELENLVELREGELKLSQEDRDHWQQRCQNILSKYDRVDPAELEALKEKIATLEKERDEIKTEYDSAVAERDEARTALQKHVDDLPTVIKNAKAEQKTVLETQFKEVLRKNRTVLVERKAELDAALAEKVVLQEELDSAKAQLAAAPTESAVSVPQANGVAEVQPTVVPTDGPSSTTDNTAVPELEAKVRELEASLVAKDKEIQDMTSSQDEKYNNRISAMEKILNKRLQEVKTEAQQAKVAALEELRTKLDAEHQQEMEALRASSVPVAADLQQATGDTPNAATEVAPSAATETATPVGADQLTEEVLLAIPEDKARFLVQKHEVLRKMVQTNIRNRVEKERESLRETIRKEIGEETATQGSQPSSQQIEELERRFEQEKESIIRQKESECNAEKQTLAKQYEDKLAREKQDLIVKHHEELSSQRLQFDQESERKIQEQVRNAEQMMEKRGAVKLNMATNKAAAATAKLEVVKKAAEETPEKPVGEVWNIAKDTKPPPAAPKPAATATSSAPAASAPAAAPSQPPATPDSKTNGNAQATSTEQPAPATATAAVKTEASAQKPPQQQTGAQATTTENAKQPQAGGAALMHQLQSGIPRGGSIRGPRGSGIPRGRGAPRGRGGAPHVQTGIPQQARGGGHVGSPGRGNLNPQAAQFTPGGGNKRAREDGGSADDGGQGKRIRGEGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDY8</accession>
    <name>A0A0D2BDY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">A1 cistron-splicing factor AAR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237394.1">
        <property type="nucleotide sequence ID" value="XM_016378717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDY8"/>
    <dbReference type="STRING" id="91928.A0A0D2BDY8"/>
    <dbReference type="GeneID" id="27331452"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04369"/>
    <dbReference type="HOGENOM" id="CLU_024943_2_0_1"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="199"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46382" checksum="5BDA0EEABBD1A06B" modified="2015-04-29" version="1">MDSPTILILSLPPKTFIGLDLLSFTSAPNFHGVSNVTPGLHFVYSGTDASLSIRHGRWVNITSQSQTQVLQWSAATESLDLLDPTCAPARSAINTISSQGLVDYSALQDATSDLSSHEASNSQAHRSATGDDDRGDERGESTDWRSMIFHVSPSLLTRILSPAWAVSSISSAPSDTETIPGLSHLEASDAFHQSPLNLLPVDLKQTWADEDIGRTRTDRARDRSWYLGHLIQSVTPPGSDRAVGAKQVIGELQFCFLMVLTLANYSCLEQWKRLLSVIFSCQSSLREAEAFFVEVLKVFRRQVAHIDDVEGGLFEMRDEGGSAWLRKTWGRFRATVDEVLTTNEQDKGQPDSSREEAALKKEVEQVQTLFEQKYGWASEKDILRRGMLELEDGERIEVSMLGADEDEETGEYAPVVVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE03</accession>
    <name>A0A0D2BE03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237046.1">
        <property type="nucleotide sequence ID" value="XM_016378369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE03"/>
    <dbReference type="STRING" id="91928.A0A0D2BE03"/>
    <dbReference type="GeneID" id="27331103"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04020"/>
    <dbReference type="HOGENOM" id="CLU_066247_11_3_1"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="159" mass="17684" checksum="1374934747106698" modified="2015-04-29" version="1">MSDKEFGGNDDLSLPKATVQKIISEILPQLPHDNSAAGKDGEMTFTRPARDLLISCSLEFLRMLSSESNDISERESKKTISVEHVEQALTDLGFGSYIEGCRGVVGEWQEVQKKRVGRGEKMRNFGGFDKMGEEELRKMQEALLGEARGRMEGQGDAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-05-03" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE29</accession>
    <name>A0A0D2BE29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_12105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847514">
        <property type="protein sequence ID" value="KIW09644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229860.1">
        <property type="nucleotide sequence ID" value="XM_016386412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE29"/>
    <dbReference type="GeneID" id="27339188"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12105"/>
    <dbReference type="HOGENOM" id="CLU_1023195_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW09644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="272" mass="30534" checksum="2419EF849487769E" modified="2015-04-29" version="1">MAIILEAGRIQVDQVSSTLFARLPDPAQVVRRINSRLWGTLSSEQRRRMSDVLRRSLYTSDPKMFPAAPALLPLAEVFDQCFTGLAQVSFTKIRTVTCCDGQITVKAGTTPQRENSLYLTRFPLIDAVRALFQGSHIPAGHDCSSGPGCTRSRKVRPTVLDRLPPTLVIHIPPTDEPSARAVELFRNITFTYLKPTGEVSVEYAVVACVMMSGTAGSIHFTVVWNVENESYWEYNGMRADGRLREIDSWFHIRGRPSAQQVVMMVYRWADNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF15</accession>
    <name>A0A0D2BF15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_04411</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016378759.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:PV08_04411"/>
    <dbReference type="HOGENOM" id="CLU_012348_7_1_1"/>
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    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="entry name" value="UBZ3"/>
    </dbReference>
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        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="43"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="12">
        <location>
            <begin position="577"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="593"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
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        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
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        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KIW17220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="659" mass="73835" checksum="47C94E791BBD557D" modified="2015-04-29" version="1">MSSSQPFQPSSPLASGKRRKSRFTYKQLHLLSQSSTSCPLRVIALIDYDAFYAQCEMVRLGVAESQPLAVQQWQGLIAINYPARDYGLSRHVTITEAKSKCPEIVVQHVATWREGDTKWAYRDDAASHIQTDKVSLDPYRLESRKSLALVKEILPPPPVQKVEKASIDEVFLDLSAQIHQILLERYPELKYAPYDDPTEHLPLPPSTALDWQADALVDLDSAETEDDDPDWDDVAMNIGSEIVRGVRAAIREKLKYTCSAGIARNKMMAKLGAGYRKPNQQTIVRNRAVQHFLSGFKFTKIRNLGGKLGEQVVDTFNTDEVTELLKIPIEQLKSKLGEETGTWLYGIIRGEDHSEVSSRTQIKSMLSAKSFRPSINTTDQANKWLRIFAADIYSRLVEEGVLENKRRPKTITLHHRQGGQTKSKQLPIPSGKKIDETILFELAKTLLGQVIMEGRAWPCANLSLSVGGFEEGVAGNKGIDTFLLKGEEAKAAIDTPPRSNTTTPNLEHSRPQKRRRVNDGPNITRFFARGESTEEANESAEEDMIAQEHQLEETEDSNEVRRDEGPDRRLAPAMHERDIATYFCQQCQKPINESDRGEHEDWHFAKQLQAQEAPIVSEPTNSRPPGSVQTSRTKRGGTGSSSRGRGSKPQKGQSRLAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF74</accession>
    <name>A0A0D2BF74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_11755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyt_P450"/>
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        <property type="entry name" value="Cyt_P450_CS"/>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW09979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="64666" checksum="9F4169BBCF789D01" modified="2015-04-29" version="1">MFLVVISSAVVGYFLWSVVRFVQNYHEAKRTGLPIIFTPVNAPGPLWMMLKDFLIPIASRLPLELGTWALRSDIGWTFPLKYKDHARYGDAFVIVGPGELELVLADPPATEDVMRRRNDFVKNPAMYGMLDIYGPNLDTVNGKAWDRHRKVTVPPFNEQNSALVWREAGEQAEQMLAVWSSKRQEVVRSTQRDVHALALNVLCGAGFGVKSSFVDSTLPPSSPSEDQGRSGDRDRDRDLKPQKLGYRESLRLLLADFINVVLLSLLKKGGYPDWALFGGMKKLNTAYEEFKVYMGEMIAHEKEAFARGDVSRHNLLSEMIRALDGSIAGAGLSDEEVYGNLFIYNLAGHDTTAATLHFAITLMAAHPEWQTWVAEEVDAVCKADDTGSLYYEETFPKLKRIHALMYETLRLYGPVVLMPRYTADEAQKLVIQDRVHVVPAHTTISHNFAALHRHPKYWGPDADEWRPDRWLVADGTKDGGQEEASLFQPAPGSFVPWNAGPRVCPGKKFSQVEFTRVIFHLFADGSRVRLVPEDGERYEDVKIRALQTVDAAKVVLTLKMSGTERIGLQWFRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF75</accession>
    <name>A0A0D2BF75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237491.1">
        <property type="nucleotide sequence ID" value="XM_016378814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BF75"/>
    <dbReference type="STRING" id="91928.A0A0D2BF75"/>
    <dbReference type="GeneID" id="27331549"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04466"/>
    <dbReference type="HOGENOM" id="CLU_037990_6_1_1"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29138" checksum="78F5181FE8E54A38" modified="2015-04-29" version="1">MGIPIAVRLQAYLDPLVLLGISIGYLPITLLSHPLLFLTSPQSFRSKWFESFWRVIGPKMAASEIQVDHIEEILSRARGTVLELGPGAGDQMYHYKPDQIDTLYGAEPNVFLHAKLAEVAEEKLGGGGGGGKTKFVALEAGAQPSSLVPALKKANLIDPGAGDGDGIAVFDTIVAVKSLCSAPQADLPATLALVQALLRPGGEFLFFEHVENDTDSVTMSFAWCVDWIWPVFMGGCRLKGKVDKIVLGMGGWEERNVTTIGDFKGYEVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFS1</accession>
    <name>A0A0D2BFS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230435.1">
        <property type="nucleotide sequence ID" value="XM_016385491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFS1"/>
    <dbReference type="GeneID" id="27338263"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11180"/>
    <dbReference type="HOGENOM" id="CLU_987058_0_0_1"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32824" checksum="23D29CAD00079B1D" modified="2015-04-29" version="1">MTASDQPEPEESPAASSSIGLLDLPLEVRHQVYKHLFCHRALPIPLGPGSLAPLQLQDKEDLAEPIFQTSIFRVNKALGTDALRFAYSANSFQLPADLSVFCRLGAVALASIWVLTVHNNCCLDGEESTRVWDIINHKCSGLELLIVQPSTHLLWQAIPHLKEYVASFGTDTSSRPRLVFDLYVFDRHFSFDTPEREYRRALQELKGTVVTDYRWGGPVNVREIVSFLPKHVKQINFVLDVNTGGVCALDEVLQDSADLPLVKVPLPASGKDCRYGFRDQLCYIWMDEKRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BG19</accession>
    <name>A0A0D2BG19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_04719</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237741.1">
        <property type="nucleotide sequence ID" value="XM_016379064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BG19"/>
    <dbReference type="STRING" id="91928.A0A0D2BG19"/>
    <dbReference type="MEROPS" id="M01.007"/>
    <dbReference type="GeneID" id="27331802"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04719"/>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_1"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="25"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="246"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="538"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW17525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="883" mass="98776" checksum="F53B98AFBC6D7CCA" modified="2015-04-29" version="1">MCRFMSDSPGVTSTQGRVVLPTNVVPKHYDVTLEVDFDKFTFEGSVIIDLEVAKDSTTISLNTLELDIHSTTVHADGALVTSSPSLSYDADTQTTTIDLGKSISKGQKVQLKQRYTGQLNDKMAGFYRSKRRDGQFLAVTQFEATDARRALPCFDEPALKAEFTVTLIADDDKTCLSNMDVASTEIVDSKITGGKRKAVKFNRSPRMSTYLLAFIIAELKSISTDAFRLPIKVWMTPEQNEEDGRFALDVAAKTLAFYEKAFQAPYPLPKMDMVAIPDFAAGAMENWGLVTYRVVDLLFDQKSAGAATKERVAEVVQHELAHQWFGNLVTMDFWDGLWLNEGFATWMSWYSCNEFYPEWKVWETFVIDTLQGALGLDGLRSSHPIEVPVHRAEDINQIFDAISYSKGSSVLRMISKYLGEETFIEGIRRYIKKHAWGNTQTSDLWDALGDASGKDVAHVMDIWTKNIGYPVITVSENEKDSSITVKQNRFLRTGDVKAEEDKVLYPVMLGLRTKDGVDEALMLTEREQTFKIPGGLDFYKLNADHSAFYRTSYTPERLTKLGEAAQKGLLSVEDRAGMIADAGALAASGYGKTSGILSLLQSFNTETQFVVWNEILTRINAVRNTWIFEDEATKDALKAFQLNLCSAKAHELGWEFSDDEDHILSQFKSLMFGSAGLAGDQKVQAAAKDMFSKFLAGDYAAVHPNLRASVFAMALRDGGEKEWDALLARYHSAPTADEKNTCLRSLGRAKSPELIQKTLKLALSGEVKMQDIYMPIGGLGTTSEGIEKRWEWMCQNWDELVEKLPPSMSMLSSVVSICVAGFTREKQLKQVEAFFQDKDKKGFDRSLQQSFDSIRAKANWLQRDSEDVVGWLKANGYLEKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGI2</accession>
    <name>A0A0D2BGI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230660.1">
        <property type="nucleotide sequence ID" value="XM_016385716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGI2"/>
    <dbReference type="GeneID" id="27338491"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11408"/>
    <dbReference type="HOGENOM" id="CLU_006937_6_2_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF8">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="65604" checksum="D48086177E80E9AA" modified="2015-04-29" version="1">MITQPTSEYQILPQYHSQPRRLKIIHVGAGASGLLFAYKAKRLLLNYELTCYEKNPSIGGTWFENKYPGCACDIPAHTYTYPFQPNTEWSGFYSCADEILAYFQNFHDEHELAPYIKLSTEVPSATWDEDSAEWEIELKNAEGIFKDRCHVLINGAGVVNKWKWPAIEGRELYKGILSHSANWDTSIKWEGKRVAVIRTGSSSIQMVPQMAKGSQTLTVFARNSTYISPLVSPGDYRVHPDGKHHYLEVEKEVFRTDPARHLQYRKDQETVLTKQFPIFIRGTPESVMAKEALTAQMLARIGPGHDELKKRFIPDWAPGCRRLTPGEGYLETLVLDHVRVAYDEIDRFTETGVVTAAGEELDFDIMACATGFDVSFIPHFNIVGRKGVSMREEWKGNVNIYLGITAPNYPNYFVIDGPTANWGNGCVMPSHEVHIEYALKCCRKLQEDRRRAFSPWSLDRDRRPRSGSTWILGTRNVASGVTTAGPGTKTTGPTVASTSGQEVCCTISRPSGSLATSTTTCGFGTRMSGPSWVTAARTWRSSGRTDLTSISNGPLHQEFRRPLDLGPAARLAAEAGGGEEGFVVVIATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BH24</accession>
    <name>A0A0D2BH24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11608</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230860.1">
        <property type="nucleotide sequence ID" value="XM_016385916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BH24"/>
    <dbReference type="GeneID" id="27338691"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11608"/>
    <dbReference type="HOGENOM" id="CLU_022256_1_2_1"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="27"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="442" mass="48997" checksum="C21A6A83ACC111FA" modified="2015-04-29" version="1">MSTTKQLHLTAFMRPVSLHTGAWRYPGAFPDANFNLGHLKSFIKALEDAKFDAFFLADHLAVLNMPVEALKRSHTVTSFEPFTLLSALSVETERIGLAATASTTYEEPYHVARRFASLDHLSNGRAAWNIVTTGNPESSKNFSRDEHMEHSDRYKRAREFYDVVTGLWDSFADDAFVRDQQTGTYFDPERLHVLNHRGNEFQVRGPLNIARPVQGWPVIVQAGQSEPGKQLAAETAEAVFCSPRDLASAKTLYEDIKGRATAAGRERSHIKILPAAFIVIGDTIEEAKSKRLKLDSLVHYDSAIASLSIALGSDASGFDPDGPLPTDIPDTNASKTGRAGVLKLAQDENLTVRQLAQRYGGYSGLAFVGTPESVADEMQTWLAEEAADGFTVAFPFLPQGLEDVTQRLIPELQRRGIFRREYQGSTLREHLGLPRPSNRFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BI27</accession>
    <name>A0A0D2BI27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_02892</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238819.1">
        <property type="nucleotide sequence ID" value="XM_016377249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BI27"/>
    <dbReference type="STRING" id="91928.A0A0D2BI27"/>
    <dbReference type="GeneID" id="27329975"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02892"/>
    <dbReference type="HOGENOM" id="CLU_014490_0_0_1"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000146">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000239">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZINC FINGER PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
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            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
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        <location>
            <begin position="490"/>
            <end position="517"/>
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    </feature>
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            <end position="31"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="329"/>
            <end position="458"/>
        </location>
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        <location>
            <begin position="10"/>
            <end position="28"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
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        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW18603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="685" mass="74675" checksum="869D00679DA462BC" modified="2015-04-29" version="1">MDDSRGRSPSRGNAQHISPQPSPNQYATTVPGVIPSVQAALTSGKFINSNTQPFSNPFFDPSQQNGLQTNSAEPSFYGNSQYQDTFQTNQFDNQSFDPSFNSNFMFQGENMSNEYQNYTLSNAYDMNPQTNINPADLSKVSSPPQDQQSPSLLPPENLSSQPGSPASTNGQFYTPQHSRHASLDPSSAYGDSYSGLNFQQHRRAPSDHSEISSASHSPYLGHSDLHDPTDLNHSPFLQAQPDTNNAFGMETFSLGEQASYRSPRLMPHLEGNQQGVGAEQGLSLNQPMGGIPIPNVYTSEASAYPSIIPSNHMRNTSVVSDIGQADQFAPPTINIEPAPVSRQQSFGPQGEAVEGALSPPSSNRGRSRSKSDVTFSRPLSRAGTPSTNNLAVSRSPDRGARSLSRDSSPGPVASGRVEKNRRASTSSMGQSRDYILDLADPSRPNASPSGQSARVQKHPATFQCNLCPKRFTRAYNLRSHLRTHTDERPFVCTVCGKAFARQHDRKRHEGLHSGEKKFVCKGELHSNPGQYWGCGRRFARADALGRHFRSEAGRICIKPLLEEEKAERQNRAIMEQQQHQQAQFAQNLQPVPQPMMIGMDPSTGTGGFALPAALLQQYPALQNIDWSQISTVDDQGDLSDVGGMGRASFDGSSGGEYYDEDISDGYVSGNGLDFSNPGPQMYMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKJ5</accession>
    <name>A0A0D2BKJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Choline transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016374393.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27327108"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00025"/>
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    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF27">
        <property type="entry name" value="CHOLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="139"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="57677" checksum="2B37868A8F4E6AF7" modified="2015-04-29" version="1">MSPAEVHTNAHIDRIDDDAAVLAALGHEEELNRQFSFFSLAAYATITANAWTSIAGSLITAIYNGGAPGLLYGWVVDNFFYFFIALSLAELTSSMPTSAGVYHWSAALAGPKYSKIIGFMTGYMNVLGWALGLASLFAVTGLEVTGLYALWHPEYESKTWHVFVVFVALNWTFAAFIQFGNRFLPLYNKIGLFFNICAWLVVIICLASIPPTHSTSSFVWTDYSNLTGWPNGMSFILGLVAPAFAIGTIDSTTHMAEEIPHPSRNVPRAMFVQWLGSFLLGFLFLIALFYVAGSLDTILAANPTFPVASIMDSAFENKNAAFACGLIIFLASLPCSIGAQITTVRCTWSFARDGALPFSSYFAKIDEKNVMPARANILIASISTALGAIYVGSTIAFNALVASYAVMSTTSYGIAIGVNLLTGRKRTIPGWFHMGHGPLGFIVNSIAMIYIVVSNVFFCLPYFRPPVTAATMNYTSLVSYGLALLVVLWWFVGGKKSYRGPKLSSQTLEALEGVRLDTASAVEPKNGDSAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKT3</accession>
    <name>A0A0D2BKT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239749.1">
        <property type="nucleotide sequence ID" value="XM_016374473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKT3"/>
    <dbReference type="GeneID" id="27327188"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00105"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="OrthoDB" id="4500315at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000396">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="89823" checksum="E983743AC2C1BCD6" modified="2015-04-29" version="1">MAPKIEKWSLGILNDKETEEVPGTVLLLSSNRNEPLGLEHQHARRSSSSMPAQPLTPPLRRPSYPTQKKTRDGQFILDPQPDDSLNDPLNWPAWRRDVALLSLGFYCMVGGGITPILAAGFNNVAETYHVSYSRVALTTGFYMMGLGVGSVIFSPTAILWGKRPVYLASAIMFMVTSVWCAVAPSYAQLATARVFQGISVSPVECLPSATIAEIFFLHERAFRVGIYTLLLLGGKNLVPLVSAVIIGAKDWRWVFWVVTMVVGFCFCLLFLFVPETFWDRTPRAKSRRPTHQRSLSSIFRHPLTDAKSHEQHPNSADPAALQAAIEKTMTPRQYMLHEQNVHARFEDSASDTKLDEESNTSINAQSEAIDHARYTEETKQPISEGSTASGSCDEKEESGLDDVQTSEPVTETSGRRRPKPTGLSMPPPPVLHGLPTHGADGSNGDNTPTRAPRTSPGDPVIVEPEAVAKARGSSVPHLHSLNSPYYVALEKNNDYLGGRITPTTQPARADGAAQQDAIPGTAPNAVSIPVTASQSPATSEKSRTADGYFPSDSLKLGRYTTTLRHAPPKTYLDTLKPWNGRLSKSNWFLVACRPFILYAYPSVLWSALVYSLSVGWLIVLSESITAIYKNRESYNFTSLQAGLVYISPFIGGVLGTAVAGKVSDIIVRYMARKNGGVYEPEFRLVMGIPIAITTAIGLMGYGWSAQERDNWIVPTIFFGLISFGCSLGSTTSITFCVDSYRQYAGEALVTLNFSKNIFHGLVFSLFFADWLEADGPRTTFLAIGAIQVICLISTIPMYIYGKRARMWTVRKSFMEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKX5</accession>
    <name>A0A0D2BKX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239471.1">
        <property type="nucleotide sequence ID" value="XM_016377901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKX5"/>
    <dbReference type="STRING" id="91928.A0A0D2BKX5"/>
    <dbReference type="GeneID" id="27330632"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03549"/>
    <dbReference type="HOGENOM" id="CLU_011226_14_0_1"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="114"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27939" checksum="7536C1F4A188F934" modified="2015-04-29" version="1">MASSSNLYIAETPKEVSSAKGLHLITQNTPNGQATQIILEELHDLYGTEWGTTLINISTNEQKKEWFLRLNPNGRIPTLVDNSQSPPFPVIETSAQILYLVKFYDKDDVFGFKDELERNEALQWMFFWHGGGAPYQGQVNHFTRAAPEKIPYAINRYKNETLRVYGVLEIRLSGIYTGGPRDYLAGKGKGKYSVADIKTWPWIKGWERSGFTAEDMKPFPHLLKWIDRIAARPAVQRGIGEKYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLV6</accession>
    <name>A0A0D2BLV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anhydro-N-acetylmuramic acid kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239751.1">
        <property type="nucleotide sequence ID" value="XM_016374475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLV6"/>
    <dbReference type="STRING" id="91928.A0A0D2BLV6"/>
    <dbReference type="GeneID" id="27327190"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00107"/>
    <dbReference type="HOGENOM" id="CLU_038782_1_0_1"/>
    <dbReference type="OrthoDB" id="5427593at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF2">
        <property type="entry name" value="UPF0075 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="48544" checksum="90701B31490F8992" modified="2015-04-29" version="1">MAISEWTGKPLSLKVIGTNAGTSMDGLDVVHMHFTQDSPTSPLKMQLLHAGEVPFDGDLKKRVMRLIKENKTTPEEISIVNIQLGEFAANAIIQFSQEQGFSLENDVDIIAGQGQTIWHLPLPEMFEGNPQRAHLDMAEISIIAAKTGITSLSNFRVSDMALGRQGCPLFVAWDGLSATHPTKNRAVQNIGGIANITMLPKGDIQQGYDFDTGPGNVFIDAAVRYFTNGKQQYDKDGKMGAAGKVDQSIVDEVLAGPYFVHDIPKTTGRETFGDTMGEDICERMLAKGASPEDCVATITRITAKALADAYEKWGPKGGIDEIYLGGGGSYNPNIINYLRERMPNTKIAFLDELGVPTGSREAMSFGFKGLECILGRSLVVPQRVESSRAGIIGHIQPGSGLAYHRLMKHVQDFWGSYPLEKRMDPVLEMEIVRPTANGANGVNGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM40</accession>
    <name>A0A0D2BM40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239876.1">
        <property type="nucleotide sequence ID" value="XM_016374600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM40"/>
    <dbReference type="GeneID" id="27327317"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00234"/>
    <dbReference type="HOGENOM" id="CLU_806614_0_0_1"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39873" checksum="809C2602C8753260" modified="2015-04-29" version="1">MQPAWVTSSSPSATPLPSTSPYRQTTLLSLPPEVRNLIYRYAFQQDEPLRLRCPSQRRLRPSRPPKDDTRAFLDSCHLVRSEALCLYYSLNSLVFRSTQHLLSFIADTGIHPCIKSSLAHVAVDFGDATDSDAFLKDHIILVDTCVGSLPRLKALETRFYARTMDACSLQHFQTLALALDGLDAEMNAPPSPRSSRSSRRSSRQSSVSSHRASSPVSEASSICSTPMELVCEPESIEPEQDQPEPEFDMSAIQAEVLEQYCFTPSAAVAFASSKLKFSVAASSHEYPGAKHDKLICYNLRISADGVRSALGDAKEAVQQRLTRVGMLPRRLSEMYDVSADGGFHQRVRATIASCARIDVGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMT9</accession>
    <name>A0A0D2BMT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232665.1">
        <property type="nucleotide sequence ID" value="XM_016384042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMT9"/>
    <dbReference type="GeneID" id="27336809"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09726"/>
    <dbReference type="HOGENOM" id="CLU_064985_1_1_1"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="263" mass="28833" checksum="2DD6CC362B1F2DCF" modified="2015-04-29" version="1">MGTVTYRDGIAILQLVVFPFIFAAALFIWKRAGWKAGRKVWRFAVVLALIRIAGSICSLLTISHDSYNLEVAVAVCELIGIAPLLLTYVGILRQIDIDTKVNPKFLNLLAAACFIGVGLGIAGVSTANDSDTTYHPNSIVKASMGVFLAVFAVVVVVCGLLYLKLRHTLRAFQKKLFLASVLSYPFLLVRLVYSALSDYTSWSNFAVLIGDATIYLCMSVLEEIVAIALAMMFGISAVLQDDFVKPDSKTSYQQFELREEVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMX3</accession>
    <name>A0A0D2BMX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_09751</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232690.1">
        <property type="nucleotide sequence ID" value="XM_016384067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMX3"/>
    <dbReference type="STRING" id="91928.A0A0D2BMX3"/>
    <dbReference type="GeneID" id="27336834"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09751"/>
    <dbReference type="HOGENOM" id="CLU_003488_0_0_1"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="10">
        <location>
            <begin position="24"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="621"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="11">
        <location>
            <begin position="856"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="811"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW12474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="963" mass="107815" checksum="7FE022B95E9BFAA6" modified="2015-04-29" version="1">MALDLDEGYVAQGLARGGVETSLPIFNVERVQLQFNIASDFVAGQVANNVLILALATGRILRIDLESPSDIDDVDLPKKTSEVGLIRRMFLDPSASHLIISTTLGENFYLHSQSKQPKSLSRLKGVLIESVAWNPSQPTASTREILVGATDGNIYEIYIEPASEFYRREERYSANVWKIPEGAVTGLWAESIQGKSDTRRVIVASRSKLYHWIGKTAGRGKEGSTSLYTDLFSKEEPVIHATNGASSTAPSSLSVSPESPEAGSEEERSFGWLYSQGVLTGELLTTPATADLGNRIFQDAKLHPRSIFPETMSARGGRKLIQDPIVSAILSQWHVLALVEGRIVAVNRLDGSVVYDQAVLEPGQSALGLVSDQKKNTFWLFTSQEIFEIVANDEERDIWKIMLQNQDYDAALRYARGATQKDSVATASGDYLSSKGQYMEAASVWGRSSKAFEEVCLSLIDNAQDDALRKYLMTKLGAYKKSSVMQRVMVATWLIQIFMAKLNSLDDMVATKAELLENTDAGGAKRDLEQTRSEFQEFVTKYKADLDAKTVYEVVSSHDREDELLFFANTITDYDYVLSYWVQREKWNEALSVLNKQTNPETFYRYSNVLMIHVPTGLVEILVRRSNLDAQKLIPALLAYNETANVPLAQNQAVRYLNFVVSNNFEVPASVHNALISIMASHPSPSESALLGYLESQPSPPLYDADFALRLCIQHDRVQSCVHIYSTMGQYQQAVQLALQHDDIDLAAIVADRLEGNDKLRKKLWLLIAEKKIKEAESIKEAINFLKRCELLRIEDLIPLFPDFVVIDDFKEEICEALEEYSRHIDSLKHEMDLSQHTAEQIKAEIAALDHRYAIVESGERCWICTLPVLSRQFFVFPCQHAFHSDCLGKRVLESSGSSKRKRIKDLQTEVNQGLSVGVQRQKLVQELDGLVAEQCVLCGDLGIKQIDEPFIHEGDDVEAWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN27</accession>
    <name>A0A0D2BN27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional regulatory protein DEP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240176.1">
        <property type="nucleotide sequence ID" value="XM_016374900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN27"/>
    <dbReference type="STRING" id="91928.A0A0D2BN27"/>
    <dbReference type="GeneID" id="27327618"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00535"/>
    <dbReference type="HOGENOM" id="CLU_012439_0_0_1"/>
    <dbReference type="OrthoDB" id="20886at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
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    <sequence length="664" mass="73514" checksum="7C6E032B34CE8453" modified="2015-04-29" version="1">MDSAADSLLALSNTVATIAPDHEPLSDDDRSSSLSELDENLEDGEEEELEAQRPGDVDSEAETERLQVTPDGLVKKKPFEVSPSKLVQREDVDMRPEIESLTGSPVSSPISSHADSDLDGELSDVPEAEDEVEAEPEAVTVNSPNKRKREESDSDPDAAPRSQRRRTGSVESRQEKSEPESEPEDSRRPSREQTHEPEIEARGNEDEEAEEPEEEPKEAEKVESSEDSKGKPRTRPRRKAKGDVIQEPQADEEEEPEGAEESEAVDENDAEAAAKSEEEQARRMAAMEALTSLEKHFAALRDRLYDEKIAAINHELALLQEARPSHPELIRQVEAVQKYRDEKFEVEQKLLVYKVGALKNKAVADRSQIHSQYFQTVRDIRERFLERISEHFYRIQRDRFKADSTVPSFTIPFPEKRSQQIIQQTAYNKEVSILSGVAKYVGFPAAPELAPSKQKDIQDDMAKMGISASQIQPIRATRPVQSTAIAQISAPQAEEQFLEQTPWANPQHPIHRLSRQNSNRSPMNEFLTPAHQQRTTEATQPHGSASTIADPSAQISSAINTPHDGPSSATHIDHQAGSSSNHNYRLHSASPLGTRDMQTKDSIRDIGSSPLNSRAQGSSPRTGSTRPDTRMLGVNNDSPFKSKDAGATAITAGSGFGGTGRFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN39</accession>
    <name>A0A0D2BN39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_00928</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KIW20353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016375293.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:PV08_00928"/>
    <dbReference type="HOGENOM" id="CLU_338896_0_0_1"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
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        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
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        <location>
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    </feature>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50030"/>
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        <source>
            <dbReference type="PROSITE" id="PS50053"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KIW20353.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="839" mass="90248" checksum="E0FC8AA851864858" modified="2015-04-29" version="1">MADSKEDLTDKAHFDPNWIAWNGGYLHSNNVLFYFATSPFFDQVSGNQSLFTQWAGTPNQNDILGTRAKFEANLRHQRGIQYVVEHDPLEENVTHDGPNGPEKSNVWVIRKQNRETEADSSVTTLGYYYIVNDVIYQAPPVASIFNYRMLNTVSALETVFSAPADMSFFDVSHGHTYHKPGHKSTSQALNSASQQSKEDTPLPGTQPPAGEKANGTRPQADGEIDGRTLWDALRMTLQHGKEYTDDVSLVGEPGNFRFSKNREAATGQPKSQIQGAATATPTQSRAASAVPAAKSPGAGLVKGSKAGEKTISAVKIRGVKQENQVPRIDTLFLLVCVNPAFASVHVKGSPGLPQWGLVHEQAVVSYGRRRHSQKSIITFTVTYFAAPLPQSLTLPRRLYLLFFVAIQNYNHTAFARHLYRSIHPQPLLDVSCLIKRPDQTRLASRGTMKLSFRDLKQQKFTIDAEPTDTIAQVKEKVAAEKGWDASSQKLIYSGKVLADANTVESYKIEEKGFIVCMVSKPKAAPAAKPAPPSTPAASTSASTPAAPPAPAAPATQPAAAANLPSTPTPGQAAASAPEVERGFNDPSAFLMGSRNEGPIREMEAMGFERSQIDAALRAAFFNPDRAIEYLLNGIPENAGPTEPSTSDTPNRSSATSPPAAAAQTAQPAQTGGDEPINLFEAAAQANQGGRGSGGAGAGATRGAGAAATGAQGANMDLTYLRNSPHFQQLRQIVQQQPSMLEPILQQVAEGNPQLAQMISLNPDQFLQLLAEGHEEGDGAPPMGAGVVTVTPEERDAIERLCRLGFSRDQVIQAYFACDKNEELAANFLFEQPEDDEPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPN8</accession>
    <name>A0A0D2BPN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240701.1">
        <property type="nucleotide sequence ID" value="XM_016375425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPN8"/>
    <dbReference type="GeneID" id="27328143"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01060"/>
    <dbReference type="HOGENOM" id="CLU_144283_0_0_1"/>
    <dbReference type="OrthoDB" id="5216128at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="130" mass="14249" checksum="6BB51CCFA8C913AE" modified="2015-04-29" version="1">MSAQSHPFFYNTSLALSVFPMLFGINAMLRPDSHLRALGFPLHTEPTAKKLNLALMRIWSIRNLSVGFLLALIWNTGDEKLMAKALGAGMAMATTDGFVSRLLIGGGETQHWIFPPVLGVVIAGLYGWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPV9</accession>
    <name>A0A0D2BPV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PV08_01105</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of Ku70 and Ku80.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240746.1">
        <property type="nucleotide sequence ID" value="XM_016375470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPV9"/>
    <dbReference type="STRING" id="91928.A0A0D2BPV9"/>
    <dbReference type="GeneID" id="27328188"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01105"/>
    <dbReference type="HOGENOM" id="CLU_014815_3_0_1"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000004">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="23">
        <location>
            <begin position="641"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="596"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity" evidence="21">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR003033-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KIW20530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="678" mass="75363" checksum="8567100FD9FCFD3F" modified="2015-04-29" version="1">MADLSYRSKAEDDAAREDGEDDEEDDIDESGYKTVKDAVLFAIEVSDSMLKKPPSSGSKKSDTTSPLLAALKCAYHLMQQRIISTPRDLMGILLYGTEATKFYDEDENSGGGWSFPHCYLLIDLDVPEASDVKELKELTEADSPESNDIFRPSKEPVTMHNVLFCANQIFQQKAANFTSRRLFIVTDNDDPHAVNKETRAQATVRAKDLYDLGVIIELFPISTPEHTFDTKHFYDDIIYKASPSDPDAIAYNPSSIVDSNESRLAAGSNDGISLLQSLLTNIASKVTPKRALFSSVPLEIGPGLEISVKGYLLYKHQKPARSSYIYLGSERPQIVTGSTEQVAEDTRQIQKAEIRKAYTFGGEQITFKLEEAQKLRDFGKPVIRIIGFKPMARLPLWANLKNSSFLYPSEEHVVGSTRVYSALYQKLSRDKLFGLTWFIPRKNATPVMAAMVPTLSAEPTDGRSNAAGVSPTGAPQGLHLIPLPFADDIRPNPPTTRQEPLHAPDDLVDAMRPIIQQLNLPKGIYDPSKYPNPSLQWHYRILQALALDDEIPEKPEDKTIPKYRQIDKRVGNETIEWGKTLERVFKEFHIDHPDAIPTGSKRYTNGHGSSASGSAAKKAKTEGGDGISEDEVRSLWQKGKLSSLTVAQIKDFCGAKKLSVAGKKADLVDRLEQWLESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQC1</accession>
    <name>A0A0D2BQC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233550.1">
        <property type="nucleotide sequence ID" value="XM_016382847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQC1"/>
    <dbReference type="STRING" id="91928.A0A0D2BQC1"/>
    <dbReference type="GeneID" id="27335605"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08522"/>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="23"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="407" mass="47185" checksum="F51B0876E28ABA37" modified="2015-04-29" version="1">MIRLIKTSDLSQHVFEGRSVPGYVILSHRWEEGEISLGELQGNLNLHKQGWLKLQRFCQFAETRGHRFVWIDTCCIDKTSSAELQEAINSMFRWYRRAECCYVYLCDVPARDDLDLPEWTKIFKASKWFTRGWTLQELLAPHRLTFVCSDWKEEIGSRQSLSHEVSEVTRIPEKPLVQGWSLKDDFGGAEFTVAQIMSWASKRSTTRVEDTAYSMMGLFHINMPLLYGEGSNAFIRLQLEIMSKYDDNSLFAWGIPLRDRHFESNSALNRALDIPEAYWWGGLLAPAIHCFEDCAGHFHHLERYEDARLFSMTSKGIQVEGLLRRYEKARYGGSHWLLPLNCGREAHLKHRLGIVLAGDGQLAMRVVNVQSVEPGLVECHWDAERELKAEYEYRRVFVPQAWPGDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRU9</accession>
    <name>A0A0D2BRU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_01715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241351.1">
        <property type="nucleotide sequence ID" value="XM_016376075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRU9"/>
    <dbReference type="GeneID" id="27328798"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01715"/>
    <dbReference type="HOGENOM" id="CLU_556709_0_0_1"/>
    <dbReference type="OrthoDB" id="2285533at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF9">
        <property type="entry name" value="MEAB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="490" mass="54711" checksum="858B307B61BAEFD9" modified="2015-04-29" version="1">MHPTELSDRASLDPDVFRRESRMSKEELWLSSRALTYFFAGIDNEGGHDCVDAAEDSSLQISSTTSSKDKRGKQVVSLRVCSPLAERSYTHAVGQASAVLEDRRQRNRQAQATFRLRRNEHLKQLEATIQQHQQTIRDLQESVRVASDDCLMLRYKNSILERVLLEKGIDVREEVYAKPLLPTKRRVSGASSRNSSSVQCGRNKRARDTLYPGSAPAVQAPVQTKTTSSSFHVGRLVPEVFASAPATSSVAPSVSEQSQSSTSRSPRLSQWQPRTTVSAETGMRTVRATKQAQDFQQAARARKHDLEHPHHNRSALQMPRPTSTTTSQSASRPRDPSRGHSVVPYSTMATATSEEAGHGHEVSFEKTTKKPHHALGKLPPSLFCPFLLGSCDHVHVREHEHEHEHDPDCELLLTTEPSHHDVHAHHFDFDLGIDIDMDMLENTLPELVPSQSTPTTVTYEELQDLSPFNAYGGGLDWTRSSNLVFEKPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSY8</accession>
    <name>A0A0D2BSY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234605.1">
        <property type="nucleotide sequence ID" value="XM_016381503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSY8"/>
    <dbReference type="STRING" id="91928.A0A0D2BSY8"/>
    <dbReference type="GeneID" id="27334254"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07171"/>
    <dbReference type="HOGENOM" id="CLU_008511_1_1_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="699"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="772" mass="86517" checksum="33CBA73862BAF305" modified="2015-04-29" version="1">MDQRGPETQNAPVQEDGEAPYNTDGNAPRKRKKAVLACDPCRVRHLKCDGTHPVCWQCARRRAPAGTRVEPCTYKSCPQEILRQKEYIDTLHYRIEQLERVNRELSNLRTSSDPGVGSQQPRCTDSPGSTQQGFAVQHPETATSNPTPPRNQEGYSPVDAMGANSAERPHEQAHDSRYYGSSSTVSFMQQVYSTIPNGDPAGASTGPLRNPHWPSVNLMDSTFWALKDPGQLSLLPRPIMDAALGTYWERIYPLYPFIHKPTFTRAYEQLWDPGPAESELNTPEAGLGGSAEYGPRSIVYHCALNVMLALATQFMNMPRDDRRRLEEVFANKARDLCRLDLFDDGSLAVIQTLLIMTQYLQCTPHPNRCWLCIGITCRLAQSLGLHIENPQAGKWTGPFALEMRRRVWYGCVTLDAVVSMTLGRPLMLSPPGNIPLPRAIDDYYLDRPNGQPPGYPSRLEFFVRSVKLYVMLGQVVSQIYAPSSTPQVSGQSSAKFANFGDFAFVQRMDTDIAAFEADIPHHLHWERRHKLPPDLFDGRVFEMQASVLYARYLHLRILLYRPMFIHYCQHVCSQAEEGTMDPTYRPPAPATEVSLIFARGVSIMCVENSARLIDQVHLRSTTAATGAWWYNLYYARTAGLVVLLAMACDTITESVGWTKLAESWNKCKATLSALLVFSPAATHCLRGLERLHQHIVSFKPGHRPGEDPQGGGADVYEWNRDRDGNAHSQSQLPDHNFEPGGASLPDDLGGLEWPNEMETSMLEGIFSFDAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVE6</accession>
    <name>A0A0D2BVE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235465.1">
        <property type="nucleotide sequence ID" value="XM_016379638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVE6"/>
    <dbReference type="STRING" id="91928.A0A0D2BVE6"/>
    <dbReference type="GeneID" id="27332377"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05294"/>
    <dbReference type="HOGENOM" id="CLU_007773_1_0_1"/>
    <dbReference type="OrthoDB" id="4120271at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23625">
        <property type="entry name" value="UIM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="733"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="839"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="950" mass="103170" checksum="B7926964305B14E7" modified="2015-04-29" version="1">MEPENDQPGLVDLVSDSESDEEVFDHLNPLGNEPVHSSIITPSHGDPMSAMRSLFPTDRSPRCLLPGRQETSDNDLSGSSSGNGGDSANPAVSTTAGIVGSKTQKPVIVDIIDEDDSSGSHTEAGSDSDSKGFRVLPGSSSNAESDRRAHQNREEDGTNSKHTTTIDLSQLSDEDDEDWRRAIALSLRDSTAQNAGNDSPSEKNSSKTESEDEDLKKAIALSLLDTDAVGGPNSSASCSSPKGNDQRGILTAKPERRREKSKETKINGIDAAVQHAEGGMEKSSDTIAIATTSSDTLVTSTPEPDSIAGSTLKTNTKPLDRDASTKKSGFSILALNRKQMEEERLARLKRKREGDMNSVNGKDSKTLRLDQNASSETRKTKISPPPSQRRAHRTGTQETSISRPIGVNRNAAGQGIPSTSASSIRNHSSAPSTTPQLFPEGKIFKTALADSSNVSSIGTISFDQLVSPSTSLESALLSSFIWDFDWLFPHFDTKRTKFQLVMHGKSASQRTSITSDFSGLNNVRITFPPVEGITNCMHSKLMLLFYRDELKPALAPPLGVTTRLGDGETKEQDWSKRCRVVIPTANLVGFDWGVGSFMENTVFLIDLPLKSPGVDTRTQFETSLRAFLKAQTVPDDVLTKLSKFDFDRASHLAFVHTLGGAHTNRQVIQSTGLPGLANAVAQLGLATCRDLQLDYVTSSLGNLNEAFMRNVYWAAQGDISSFGLAAASMSSSSSTSRSEARDNPAGLLDGARGKEKQEEDAWRRNFRIYYPSDTTVRTSKGGMQNAGTICFSGKWWAQQSFPQSNLRDCISLREGLLMHNKILYVRPTLATLAGTAVPHSSSHEHSRSILQPQRPWVYLGSANLSESAWGKLVEDRSTRQPKLNCRNWECGVIIQVPLTDEQTETTGLVESGQAHSEESLAVFEQTVGAPMRFPGESLVQMGKKPWTLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVG3</accession>
    <name>A0A0D2BVG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235490.1">
        <property type="nucleotide sequence ID" value="XM_016379663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVG3"/>
    <dbReference type="STRING" id="91928.A0A0D2BVG3"/>
    <dbReference type="GeneID" id="27332402"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05319"/>
    <dbReference type="HOGENOM" id="CLU_009665_3_2_1"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="131"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW15274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="411" mass="46557" checksum="F88D0A5AE1E0C4AF" modified="2015-04-29" version="1">MAEKKDPFHVLIIGSGMVVILVTLRPAINDDLYYVEQEGISYAIYESEPSATTYRPREWGMSVQWGLPMLADCLPKELFDRIYTAAVDPNFEPPDPGILPTYNGETGELMKNIPLLRMYRVSRRRFRKLCSEGIDVQYNKTFTEVTYDDDNSTVTAVFQDGSQATGNLLIGADGVKSKVRESIFGEEGQALSVPYSAVNLHVCYNDADKARFVRQGHPIMTMGMHPNGYWQWISIQEVPDPDNPATWVFQLQTTWHRKEGEQVDSLANLKAKAETMGEPFRSANLWIPEGTKVYSNNLSYWIPRPWDTHKGRVLLAGDAAHPMTFQRGQGLNHGIADSRSLVLKYKNAQEGKTSYEEAAEAYQAEMVDRAGEEVRLSKENTEMLHDWERMANSPIMQRGGHPREQQQSSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BY52</accession>
    <name>A0A0D2BY52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236460.1">
        <property type="nucleotide sequence ID" value="XM_016380633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BY52"/>
    <dbReference type="GeneID" id="27333378"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06295"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_4_1"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="56196" checksum="2D790AFA60541AAB" modified="2015-04-29" version="1">MSTLSSHEHKIQAMSGDQRADKEPAIHSVPTTDTNIGRVSTHKKPFTVLSALSLGFNITNTGISMVLVISNTVFGAGPLFFYSTLLIAAVTFCVAVTLGELVSAYPHAGGQYFWAAQLSPERYRRFFSYMTAILSWAAVICICASSAQASANITFQMVLLSRPDFGYQRWMGFLAMEGYNILAASLTVYEYVLPKLSKGFLMFVIVVTSALFIALLAPSSPKQSAAVVFGAREYFNLSGWPNGVAFLIGMNGVNWGFSCLDAATHLAEEIQHPRKNIPIALLCVTGMGLLVGIMMSLAIYFAAFDLQGTTDIIALLNAVFNNNPTCAYVLGISMLFCLVNALASAHAWQARITWSLSRDQGTPFHSYMSRLAPDPFLTPLWATLWGVCWVGLCGFLYLGSLTAFNAFVSGGVLLQYITYATPAALLLLHGRKNLIRGPFFWPKFGPVANVIVILWTLLTLIIYSFPYFLPIAADTMNYVSVMVVFAILYAITFWIAYGRKHYRLLDIQLASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C1M2</accession>
    <name>A0A0D2C1M2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_04748</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237770.1">
        <property type="nucleotide sequence ID" value="XM_016379093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C1M2"/>
    <dbReference type="STRING" id="91928.A0A0D2C1M2"/>
    <dbReference type="GeneID" id="27331831"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04748"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW17554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="550" mass="62330" checksum="199AFE782BD0BA92" modified="2015-04-29" version="1">MDMPSLLTLLHAFAAVIVLYFTGLAVFRIYFHPLAKYPGPLLAKVTQWPEARSAFRGRRFLDLHLMHEKYGDVVRFAPNSLSFRTVGALQDIYTDRRANVIKTGWTDVSLRISPGITTQVISNRQLHAARRKLLNHAFSEGALKNLEQYVLANIREWCGYMAQPKENSEKHSPWGKEREMGQWSTNLAFDVLGDLCFGKSFDAMKQGNSYIQKLIMSSAEFTTMAHRSDKETQVAYLPVRTLILPFAKPSILSRLGNNTVKQKVRYRQDIGVMVQRRFSLEKANSEKLDQEHRKDFFHYLLHAKNPETGETFQPADLVGEAALLVAAGADTSSTAMSACFFYLVRDPRVLRKLQEEVRATFNDVEEIKWGVKVTGLPYLRGCIDEALRMSPPVPGLLERRVLSGGMLVDGHSIPEGTLVGVPNYAVHHNEEYYPRPFEFLPERWVEGSDPSVTGFEVTPEMVSTAKSAFHAFSSGTRNCVGKNMAYMEMLITLARTMWLFDIRLKEGDHSGEGGPELGPGRERTGEYQLTDWFISERHGPVLEFKKREVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C442</accession>
    <name>A0A0D2C442_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Caffeine-induced death protein Cid2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238610.1">
        <property type="nucleotide sequence ID" value="XM_016377040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C442"/>
    <dbReference type="STRING" id="91928.A0A0D2C442"/>
    <dbReference type="GeneID" id="27329765"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02682"/>
    <dbReference type="HOGENOM" id="CLU_081050_1_0_1"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22882" checksum="EBB6B544AD0E0625" modified="2015-04-29" version="1">MSKPTATPPLTPQFCFDTRVLRDFLRLSRASIDDSISTTLNALITPASTSPFDPASTSIRSPGPYPRPPIPATTTRTFLENVLFPSWNSRASVIQYCTSVATSPDPEDPDVIEREALNRRDAERVVDERLDPYSARFFPREARTEMLASVLRNEVAVEGIVRARTWGTVTDRCEGVGGNWEGEFDRWKEREGGGGTGPGTGTASTRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C4K7</accession>
    <name>A0A0D2C4K7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238715.1">
        <property type="nucleotide sequence ID" value="XM_016377145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C4K7"/>
    <dbReference type="GeneID" id="27329870"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02787"/>
    <dbReference type="HOGENOM" id="CLU_113367_0_0_1"/>
    <dbReference type="OrthoDB" id="2129288at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="147" mass="17236" checksum="16B58557A3FF62D1" modified="2015-04-29" version="1">MPLWRIFSHPQTFTLDQRKTLAKKVTDLYVSIGLPAFYVNVIFIDVDEKATFVGGEQKSNFVRIAIEQIARTMASQETEQGRQQRKGWMDKINDTLKESIIDRGELDWEMHIYETPRDLWRVQGMDAPPAFSEAEKEWKEKNKPVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C505</accession>
    <name>A0A0D2C505_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238895.1">
        <property type="nucleotide sequence ID" value="XM_016377325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C505"/>
    <dbReference type="STRING" id="91928.A0A0D2C505"/>
    <dbReference type="GeneID" id="27330051"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02968"/>
    <dbReference type="HOGENOM" id="CLU_004804_2_3_1"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW18679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="742" mass="82349" checksum="A6F002326C34B299" modified="2015-04-29" version="1">MTPASSTSSSDFYHRHTPKRMRLGTRSCAECRRRRVRCTFPSDGRACEACSLHGVDCVPQKPTGQGKGAQYDPEKVELQRRLANLEAMVRQISTSANIEPETTTWAQLQLDSQKRLQSPSVALEADSIASSTRFSKLSDTDLPTDSADEMDQFEDAPLVTLFKDALKIERPPPEKDGARYSTDYRITAVIEDISPALPTLDDLRLVLEASQRFWSIWPMRPPGQGATGASRILLAQNFIVDSLNSGRPVIMAKALVWLTLCMHQLPRDFACQGTEFRRSRGHVLKRFLNAADTLLSIEGETGQGQGKDLLECLELQVKVCIDLGRPRKAWLTNRRAVNTAMLLGFQNHDTTATDEQTAIWKQLWHADRLLSLVLGLPCAISDTHPSLAKDCAGPTIESQVSHELALIAGRIVDRNMNHKTVNYSVTMDIDQDLERCKSRMPLSWRKPEFDTTLPFELAHGQQSIKLFFFSMWKTLHLPYMFKSSSDRRYEYSRIAALEACRDCIRVYKGLRDNKSGDVPVICDLMDFLAFSATVTLVIHLLSRSSKSGVDGVGLEETEDWDLVHSVSAVLSDVANKLSCSVAGQGSNLLDRLIMARRGKYADTEPFEAVIPYFGKVRIGRIPRVVKAKPTTQVQTPGPQMSAGLGAIVDGQSQSVVAQSQSSITSPTTLGLSSSSVSASSSSSQDLTSVNTVEFNLSDTTSFGQCPMDEWMSDAELTVDWESFIDVNMNYDWSQFFESAMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C5W4</accession>
    <name>A0A0D2C5W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239155.1">
        <property type="nucleotide sequence ID" value="XM_016377585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C5W4"/>
    <dbReference type="STRING" id="91928.A0A0D2C5W4"/>
    <dbReference type="GeneID" id="27330311"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03228"/>
    <dbReference type="HOGENOM" id="CLU_034311_3_0_1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="333" mass="36105" checksum="0454C32BCDBEEDCC" modified="2015-04-29" version="1">MAGKKHDTVVVVGAGIIGLASALLLAEEGLNVSIVARDIPGDGGLGWASPYAGATLIPPPELGNKEMAMESFRWYQRLAKSDPSSSVRTVKATEYFTDRENDDTIWYKEFVPEYKLLPKHSLPPGCKVGYSFETCLANPEVFLPWLKKKLEGLGVKFIRSEVKSLLEAKQMTGASVIVNASGLGAKELAGDSAVAGYRGQTMFVKSDYDEVRLINGDEYTYVIPRKFSGGVILGGISQENNFDGAVDTNLRKDILRRVNRMTGGAFEHVNIDTDVKDLVGVRPGRKGGLRVELDGSIVHAYGFKGAGYVFSFGAAAKVKRLVLQALETARPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CA26</accession>
    <name>A0A0D2CA26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240630.1">
        <property type="nucleotide sequence ID" value="XM_016375354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CA26"/>
    <dbReference type="STRING" id="91928.A0A0D2CA26"/>
    <dbReference type="GeneID" id="27328072"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00989"/>
    <dbReference type="HOGENOM" id="CLU_006465_0_0_1"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF16">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="428"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="783"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="820"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="904" mass="97449" checksum="9576B45BE85B9AF3" modified="2015-04-29" version="1">MSRPITPISPARSPFPPQPDASLQSARPTSARPPSSRPVSNIDTHHTDALSNYDQSGSYPNDPSANSPTDHLHDGEVVTGEGAPALPRTNSQMSGAQSLVPSRGGTLKKKSSLHKSASLRRTASKRSSYAGSVRSMKLGEREKYGETEETNSVFYCPVPTSGNPTEVLANRFQAWRKVLKDIINYFRDLHKTYEMRSKALLSTSNLVNSTSLPPNFLSSGGIGEANYILRDFHKQALSEASKARDLENEVIVQLTGLRSDLQQKIKEIKSLSGDFKNSVDKEQETTKRAVRSLQEALGLVDSDAASTSGKGDPFLVKLGVDKQIERQIGEENYLHRAYLNLEASGRELESIVVGEIQKAYNVLAGILRREADDAYDTAEKLKEGPLAMPKDHEWDEFTTNNNQMIDPRRPIRQVANIVYPGKDHPAAIEVRSGMLERKSKYLKNYTPGWYILSPTHLHEFKSADRVSSQTPIMSLYLPEQKLGTHSEPGSSSHKFMLKGRQTGSMHRGHAWVFRAETHDTMLAWYEDIKELTSKRGEERNEFVRRTHARSISGNSMKPASIISSEGGMEEDEADQIAFAGEQSVRGNSIANEAGMPGATGLGVLGANEVEDTRSEAGWRPPQQRPAPGGRFPSDLNIQRGLQAPLSPSSGASSDQDRDVIAAAGSLPGSGVPFSNTGDRHTELQPATAQTVPDSNDINTNSHYTAGQHPNILPVHTAIPRTQDTTSQYGEWMAPIAAGAGGAAVGAGLMHYHQQQHHEQPQPENIENQMAGGAAIPASGQSSAPIPVATAAPVNAPTGPRAMSESTTAPSSAAENATSSGTDTATLSTVPTSTGFPAGNESMFDANGVFAGPRTAKGAPTDYVVKPTERSKSHTTISDLHVPGEFPATPGLSEGPRLYGDVINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CDC3</accession>
    <name>A0A0D2CDC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241715.1">
        <property type="nucleotide sequence ID" value="XM_016376439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CDC3"/>
    <dbReference type="STRING" id="91928.A0A0D2CDC3"/>
    <dbReference type="GeneID" id="27329162"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02079"/>
    <dbReference type="HOGENOM" id="CLU_050230_2_0_1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="21"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW21499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="287" mass="31930" checksum="85D2F30DC8245C46" modified="2015-04-29" version="1">MSSTEEITSKSPAVERYLSPDKGTYQTPPPSASRSACPMINALANHGYLPRDGRQVTASDLESAMSLVGLSPSLGALFSNAVFLEHPTPGSPRPSLFSRLRAILQNPWELLPHRLGVLLPGQSDTSSTGNPHTKAKTLSLADLSLHGAIEHDVSLSRRDEAQGDNHTPQADLIYEIMASSNGDKTLTMDDLCALRKRRIETQRAENKELQYGSFEHELGCGEIALILKIFGDGERVKREYLQAFFGDERLPLAEGWNMERRNSWWKRLGLVELKWKVEQVKRKIGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8U0</accession>
    <name>A0A0D1Y8U0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231617.1">
        <property type="nucleotide sequence ID" value="XM_016385015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y8U0"/>
    <dbReference type="STRING" id="91928.A0A0D1Y8U0"/>
    <dbReference type="GeneID" id="27337784"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10701"/>
    <dbReference type="HOGENOM" id="CLU_023133_1_0_1"/>
    <dbReference type="OrthoDB" id="5590473at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF5">
        <property type="entry name" value="NYN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="497" mass="56107" checksum="D1DDF4811EEA32D5" modified="2015-04-29" version="1">MADTQDPLIWDLESAIGLLKNLSLKSQDIPPTPLSLVATFDGAQDHESTSPSLGDFSSLWDFLGRPHAADEQQAAELVKYQINDEPIAEVDLNQLNKGVRWRDEVDGADLEDNVEPAKATASYIRNKKRAERRARAKERAEKLAAQKKSTSDSTDLESGEELESLRRSPDRRAVIDDILGRSRPSVRETSPPTSPSPPKSEIRTPKREYPISHPFLWQDPDNKSPFKRTSIAPRDGRSLRQRKQALITELSRQFPDEKKYLKNPGLLEPAFTPLNVSSIGIHVFVDVSNISIGFHDCLKVARGMPRDTRLKRVPLSFHNFSLVLERGRPAAKRVLVGSDKYAAIQQAKSIGYETNILERVHKAKELTPRQRKYQSGETSGSETNNSLSMPTHAAEKWVEQAVDEILHLKILESLIDAERPSTIVLATGDAAEAEYSGGFLRMVERALEKGWSVELVSFKLNTSSLYKRKEFRQKWGPMFKWVELDPFVEYLIDEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCC4</accession>
    <name>A0A0D1YCC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232747.1">
        <property type="nucleotide sequence ID" value="XM_016384124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCC4"/>
    <dbReference type="GeneID" id="27336891"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09808"/>
    <dbReference type="HOGENOM" id="CLU_042300_0_0_1"/>
    <dbReference type="OrthoDB" id="4148626at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="359" mass="39381" checksum="7278BCC6F875A761" modified="2015-04-29" version="1">MAERSHSRLDQMSHLETSSVLSSRPVSRSTRRDMRPVTPIQIPEKSKEATTRSWEITPSSVSPSPSPSSRRTTVNFSRSFSTHNMPSSPLTQRSQHTLSRISERSPHQSMVSTNSADLFGRSSYHAAINPVDSTPLQGFPQTAADTPRRPSYVPSAASKPNFSTSQTTSTYRSSPLSTPPLAQDADSFRASASYSQSYQPAYSIAPRPRTADATISRKNAIENLRQSRVPVPEIPAPKPVVYPTTTTSGYPQVSLYQHSSKSQPDLTKRASMTGGSKRSSSGIVYDPQVPNYLSTRDDLQDLSSTLRYEGERMPVRNDHPVVGEGENVVGIVTVPGKPDTRVLKKKSLKRLPRTPSEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YE21</accession>
    <name>A0A0D1YE21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233552.1">
        <property type="nucleotide sequence ID" value="XM_016382849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YE21"/>
    <dbReference type="STRING" id="91928.A0A0D1YE21"/>
    <dbReference type="GeneID" id="27335607"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08524"/>
    <dbReference type="HOGENOM" id="CLU_022814_1_0_1"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037847">
        <property type="entry name" value="GRAMDC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402:SF1">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="618" mass="71608" checksum="A32D1A2C36DE649B" modified="2015-04-29" version="1">MSSAPLDSTGETERHANDLVDGALHLKSKAKAKVKKILNEPDHDDSIDENDIFYDAAFDPSRVLNQTSPKSQSKKSARDTIADGVKDATYIAAHPRRLIRSKVTKKAAARIGNARHPTLTVDRDRELLDAHEALDHAVSTNASTSDPRELQGEIDEASDRIRRVEEQRESLQTAWILGRHVTRVRVVRPIPRPSRPQFTSPSRFQWERYLGHLVLYYTRGFTSPYIDDFDSAPFDLEDVARIIERIAITSAPWQAFLMSVREVYMWQDPRRTGRWLALFLVLWYFQYIMAYFYFYIVYSTIRNKFQPSSVQTVRANVGRAIDREARVQAWGELIQRHGKRDWLEPFLDQIGPLIQRQLGDFADLLEVMVNFHRHEKPRLTFASVFFFSCCLAVCLCADMEFCMKVVWFVVGGGFFFSYPIATSFPKYRLLVSQFRWVFWGIPSHAELAILRLQEKAVVRDANLAEFDLHRDDDDDDDDEGDDGERTRWPMGESHAIAAVERDSGRGQLVVGRTALSWIRKTADERHWPFSELHELRKIDPDENDSMWKNLKNVHSRSSAGLEIVFLQDEITLLLHPSDRDRVFNLILAWSGQKWQSLHMERQHSHRGNLDRAIKRAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YHH5</accession>
    <name>A0A0D1YHH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234597.1">
        <property type="nucleotide sequence ID" value="XM_016381495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YHH5"/>
    <dbReference type="GeneID" id="27334246"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07163"/>
    <dbReference type="HOGENOM" id="CLU_095770_2_0_1"/>
    <dbReference type="OrthoDB" id="2679825at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="219" mass="24899" checksum="1079E7E0B2890290" modified="2015-04-29" version="1">MTSSASSSSRPQFIRSISSSSTKDKPRLYIALYPRGGSSTLSTFRSTFDCDSYHWSIIVGPQTADRKDPGVRYHIAHVLDDGDARKFIYEEQDIPSNVGAQSGLVRVAIAKVTDQRRLQGLLRDMVLREDDSAFNCLTWVREAFVKLLDDGKSVKSYLKPEDWSAVETCARKYCKRKRDAGRFRLDNNGNRRGGGDANNRWNPEMISTFNFWENRETTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIM2</accession>
    <name>A0A0D1YIM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235002.1">
        <property type="nucleotide sequence ID" value="XM_016381900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIM2"/>
    <dbReference type="STRING" id="91928.A0A0D1YIM2"/>
    <dbReference type="GeneID" id="27334654"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07571"/>
    <dbReference type="HOGENOM" id="CLU_012862_9_1_1"/>
    <dbReference type="OrthoDB" id="5607at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="2">
        <location>
            <begin position="171"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="392" mass="43271" checksum="276B9B80BA8ED9E9" modified="2015-04-29" version="1">MSRSTRAATAAARRVTLNGAVSPRLPNKEEEDFEIPIKEEQESPQRASRKRNAVAPSETKSRKKVKTEDGSGLISPPPTDDTKKTMTTPSSKKSPAKDLQAKKLKSYAQFANKSPFPDFHHPTPEECKVAHRILASLHGERVRPKEVVASTTRAGCGDSPSVLDALVRTILSQNTSDKNSTRAKLSMDKVYGGSDKWDAIVAGGQAKLQEAIKCGGLSAVKSKVIIGILQQAYEKYGEYSLDHLHQASSDDAMREMLSFQGVGPKTASCVSLFCLQRESFAVDTHVWRITGLLGWRPKSASRDETYAHLDVMIPDEDKYGLHILLVTHGKKCDECRAGGKNLGKCELRKAFRNAKVKGEAGEDAKQEEVDAIKWEKEEDEENKEPAKKRQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKQ4</accession>
    <name>A0A0D1YKQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235787.1">
        <property type="nucleotide sequence ID" value="XM_016379960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKQ4"/>
    <dbReference type="STRING" id="91928.A0A0D1YKQ4"/>
    <dbReference type="GeneID" id="27332702"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05619"/>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="323" mass="35102" checksum="1F0140966D93877F" modified="2015-04-29" version="1">MAAPTPSGKPRPTIVLGCASFGSEIDPLTRHHTTQQASELFAALTRHRHNIIDTSRRYPALAGGTSEELIGSTLRSAAFPDIEIDTKVLSAPGCHKPENIAKSISDSLRALRVDSVRTIYLHYPDRSVPLIEPIRALSHAVDIGQAKQWGLSNYTIDDVHEVLSLCKKHGLVKPAIFQGEYNAINRDSEELITLLHENGIAFYAYSPAAGGTLSPTGSRIAAQGLGGDRTRQLYGTEPVQKAIQQVRDVAEKNGLNGHETAIRWVVWDSMLDEKYGDGVIIGASSVSQLEETLRAIDEGPLPGEVNQAIEGIWASMLKDKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKS1</accession>
    <name>A0A0D1YKS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_05649</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235817.1">
        <property type="nucleotide sequence ID" value="XM_016379990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKS1"/>
    <dbReference type="STRING" id="91928.A0A0D1YKS1"/>
    <dbReference type="GeneID" id="27332732"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05649"/>
    <dbReference type="HOGENOM" id="CLU_018247_2_0_1"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW15601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="597" mass="66059" checksum="0C25665024C15147" modified="2015-04-29" version="1">MASDYSTRLQAIQQIRPHSPSPATGTARSNLAKTNLRAYTSRMVSQSVNKTALHPGGVEPGREHTELEEELHTTAHIDYDRVAIVANPSVSALYEDALVYETGTAITSSGALSAYSGNKTGRSPLDKRVVQEESSEKDVWWGPVNKPMSPEVWKINRERAIDYLNTRNRIYVIDGYAGWDERYRISVRVVCARAYHALFMRNMLIRPSREELKNFHPDYVIYNAGSFPANRYTTGMTSATSVSLNFAEKEMVILGTEYAGEMKKGVFTVLFYEMPVKHNVLTLHSSANEGEKGDVTVFFGLSGTGKTTLSADPKRKLIGDDEHCWSDKGVFNIEGGCYAKCIGLSAEKEPDIFGAIRFGSVLENVVFDPETRDVDYDDATLTENTRCAYPIEYINNAKIPCLSNNHPSNIILLTCDARGVLPPISKLNTAQTMFHFISGYTSKMAGTEDGVTEPQATFSSCFAQPFLALHPMRYAKMLADKISEHSTNAWLLNTGWVGAGAATGGKRCPLKYTRAILDAIHSGELAKAEYETYDIFNLSVPKSCPNVPDELLNPKKSWTGTANFTDEVTKLAVLFNENFKKYSDQATEEVIKAGPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YM73</accession>
    <name>A0A0D1YM73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_06162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236327.1">
        <property type="nucleotide sequence ID" value="XM_016380500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YM73"/>
    <dbReference type="GeneID" id="27333245"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06162"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="11"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW16111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="495" mass="54269" checksum="2C2D2F95F26DF44A" modified="2015-04-29" version="1">MAGSMWYTLGVSCFAAVGTFLFGFDTGIATTTIAHQSWIDYMGHPSKGLTGAVVAVYIAGEAVGALTQTFIGDQLGRIRFMQLMCIIVTVGTVIQTAAQNMGMFLAGRVLAGIAVGGMVATVPIYLSEISSPKHRGLIGGISGCGISLGTMMSNWVGFACSYASYGPTQWRLPLGIQIPWGIILFAGLATFMPNSPRQLIRKGKIDEARRHFMRIRRDLNNHEVHEEFVLMRAQIEFEMQREIKSIKEVFKLFRHRALVSIAVQTMTSLTGVNVIQYYQTILFKSLGINSHMILALAAIYGTLAFTSNVLTTRFLTDQWGRRKMILAGLSGVIIIEIYAAVMQREFQHTDNKVGKGFAVLGIYLFVVTYYGMLNSTTWLYGAEVLPVALRSKVMGLAAASHFIVNVGITEAGPSAFANIRENYYYVFVGCSAFFLAVAYFYFPETKQRTLEEVAAAFGDKVVLVTETDLAVEDAVMQDKAGAVQLERTQGKPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YTN5</accession>
    <name>A0A0D1YTN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_02879</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238807.1">
        <property type="nucleotide sequence ID" value="XM_016377237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YTN5"/>
    <dbReference type="STRING" id="91928.A0A0D1YTN5"/>
    <dbReference type="GeneID" id="27329962"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02879"/>
    <dbReference type="HOGENOM" id="CLU_018539_3_0_1"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="163"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="356"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="556"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="620"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="687"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="776"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW18591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="797" mass="89051" checksum="FBDB2B67DB525F73" modified="2015-04-29" version="1">MASSSDIRDIMNLGQAGPRQPAPKRKKLADTQPRMTGFKREVQALMGDSVPPIAIVEQRSYKSRPSISQKLFKPRHWEERPFQHGARTDGLVLRHWKRSIPGSQTRPPVVTNGEGSGDVEMTDDAKSTAAPELRYEDEYPSHKWNVKVQIPTYTDEQYENLLKADDWSREETDYLMELCREYDLRWVVIADRYDAKDIVKPSTSQENGEAAGREVAARLPERTMEALKQRYYTIAAKILETQIPISSMAQAEFQLWEKMRSFDAKTETMRKAMAEKLFERTKDEADEERTLLEELYRITKNEEDFIKMRADLYARLEPVAPIRRTERGEEQSTAMYQTSAGLSMLLQNMLAKEKRLKPPRPMPEGAHSGHSAATPTDARKASQQPSYSRRDTMDTQADETGSQKKGSVSQPTVRVLTPQEEARFGVAHPQERLTSGVQFRHEKINRLTMAKSQTQTTKIQAALTELGIPPRLLMPTERVCREFERLVKEINVLLDARKVNEKIATEIKILEEQRRIRLGLPKEGGPPGQTDGSVMEVDSSQIVDSKLETVQDSSMMAADEGKDAGGQADSTAERDHNQEKKDGAEGDESTMAVDKPDEDADADEDDEEAAAEASQLKHEEDEEQDENGDDEDQDEDADNSAAEQDQDGEDEDAEEEEEDEDDDGPQLGVDDDEDEEDGAEIAATPDIDSDADEDGENEEQDEDEDDEEDGEGDEEQEEAEAEAAEEESEGDAGQDDGEDGEDADADGDSNPAKDDPDEAVASVSAAATRAHKRSASVISEVSRAGSNRSGMGRKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YTQ4</accession>
    <name>A0A0D1YTQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_02915</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238842.1">
        <property type="nucleotide sequence ID" value="XM_016377272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YTQ4"/>
    <dbReference type="STRING" id="91928.A0A0D1YTQ4"/>
    <dbReference type="GeneID" id="27329998"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02915"/>
    <dbReference type="HOGENOM" id="CLU_015857_7_1_1"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="158"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW18626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="474" mass="51719" checksum="EEC9A77F4AFB8B34" modified="2015-04-29" version="1">MGERKVTTTQPGISPSNNTSFHRGTVESRAMAAKTADELSKLALNGSAAPAANSPAHGTNGVNGHLSDQDDSDDDDATAPGTGNTATGAAKKKKKKKPKKKKTTPKVQSDPPRVLLSQLFPNGYPVGEEVEYKNDNAYRTTNEEKRHLDRINNDFLQEYRQGAEVHRQVRKWAQANIKPGMTLTEIAEGIEDGTRALTGHWGLEEGDNIKGGVGFPTGLSINHIAAHYTPNAGNKWVLGEQDVMKVDFGVHVNGRIVDSAFTMTFDPKYDNLLAAVKDATNTGIREAGIDVRVCDIGAAIQEAMESYEVELDGKTYPVKAIRNLNGHDIVQHSIHGGKSVPIVKGGDQTKMEEGEIFAIETFGSTGRGYVVDDLEVSHYALRSDAPNTALRVQSARSLLNVIKKNFGTLPWCRRYLDRLGQEKYLLGLNNLVQSGIVEAYPPLVDVKGSYTAQFEHTILLRPNVKEVVSRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUA5</accession>
    <name>A0A0D1YUA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2237 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239057.1">
        <property type="nucleotide sequence ID" value="XM_016377487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUA5"/>
    <dbReference type="GeneID" id="27330213"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03130"/>
    <dbReference type="HOGENOM" id="CLU_127770_0_0_1"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.110">
        <property type="entry name" value="Protein of unknown function DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466:SF1">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14803" checksum="00D163F02472AEA0" modified="2015-04-29" version="1">MSGPLNVFRQPLAFFSNRPPTGFHRDGYCKTGAADFGNHAVAGVLTNEFLDFSASQGNDLRSAGLTEGCKWCLCTSRWLEALQAYRDGRISRNGVPRVHLEATEDSALRQVDLDTFREFSARPEGGANGVNGVNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YW32</accession>
    <name>A0A0D1YW32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3 8">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3 8"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239687.1">
        <property type="nucleotide sequence ID" value="XM_016374411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YW32"/>
    <dbReference type="STRING" id="91928.A0A0D1YW32"/>
    <dbReference type="GeneID" id="27327126"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00043"/>
    <dbReference type="HOGENOM" id="CLU_031312_1_1_1"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="349" mass="39134" checksum="E9B534432F0B1D4D" modified="2015-04-29" version="1">MAGATPTTAKEIQHDAIVQNTDHDAATSRLSAVDAGYLEDPFAHLIGPSEGVSRRLPLMNRGTYVRTTGIDRIVDAFLSAPENPHKQIISLGAGSDTRYFRLKQARRNVAITYHEIDFAANTRRKISHLRSPTFSVAAKTLAGIDMRAQEVDISEDGTTLTSPEYIIHPRDLRQLPHQQPGLTGLDTSLPTLIISECCLIYLPPDDADAVLQYFSNLFPSGTPLAIVIYEPIRPHDSFGRTMVNNLMNRGIQLQTLVKYADLAEQRIRLERHGFQNSTAGTLGGSRSVDIDFIWREWVEASEKERIEGLEWMDEVEEFVLLAKHYCISWGWRGYNEDGHWRSLPSAIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYW9</accession>
    <name>A0A0D1YYW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240687.1">
        <property type="nucleotide sequence ID" value="XM_016375411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYW9"/>
    <dbReference type="GeneID" id="27328129"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01046"/>
    <dbReference type="HOGENOM" id="CLU_1461333_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="185" mass="21591" checksum="43CC2C316523DE1B" modified="2015-04-29" version="1">MTEGVQGMKYKDEEIQELQVTWAQRQRDLARKRKEHAADVLMAKELGDINSSDSEYQEPKERRPRERAASEQGHRKHTENQSMILRLLGLGELNESDEDVQTALRRKVLKENIDLQTLNAKDRMQIEALDQVYQQTRERKAKNKDLAQRPFEGESLDDEELTKGQKVISELKRKMRSGKSQLTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZI3</accession>
    <name>A0A0D1YZI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240947.1">
        <property type="nucleotide sequence ID" value="XM_016375671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZI3"/>
    <dbReference type="STRING" id="91928.A0A0D1YZI3"/>
    <dbReference type="GeneID" id="27328392"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01309"/>
    <dbReference type="HOGENOM" id="CLU_039534_1_1_1"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF4">
        <property type="entry name" value="LACTONASE DRP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252323" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="2">
        <location>
            <begin position="37"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="479" mass="50704" checksum="64585159FF2C1BC6" modified="2015-04-29" version="1">MSKRSVFLTALIALLSLSSLAKSSSTCGPAPSGVIKPSVASGFHVQVVATGLSKPRGLLLDNAGNLLVVEQGRGVVSAHTLNENSGCMSVRSSVDLTSRLDLNHGIEMSDDGGTLYASSAGAVYSWSYDASARTVSNQAQIVANMTTSDHTTRTLLLSRKAPGMLVVTRGSTSNIDIDAASLESGHSQVKAFNLTNRTGVYDFDVDGLRLGWGLRNDVGVAEHPESGGIYTVENSADELTRMGVDIHEDNPAEELNFLGYLDGKEYAPQGGNFGYPWCFSAWGVDELPDNGNLTVGSQYAVDASPASHNKNQTDTYCAQQEPARLVFQAHMAPLDIKFNNSGTEAWITFHGSWDRTLPVGYMVSVVAFDRNGEPEDSLDSKDAARDVLTNQDNSKCPHSCFRPAGMAFDSHGRLYVSSDASGEIYLITRASGAKIPGPTPTSSSTSTSTATNIAGSIGPAWASGASRLSFVSMLLALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0M6</accession>
    <name>A0A0D1Z0M6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241377.1">
        <property type="nucleotide sequence ID" value="XM_016376101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0M6"/>
    <dbReference type="GeneID" id="27328824"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01741"/>
    <dbReference type="HOGENOM" id="CLU_019225_1_0_1"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000258">
        <property type="entry name" value="Flavin-binding monooxygenase-like protein (AFU_orthologue AFUA_6G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="561" mass="62820" checksum="5F0B43755C42D537" modified="2015-04-29" version="1">MDEVFDLIVVGTGWYGLAAAKTYTELHPCENVAVLETNSSVGGVWAEDRLYPGLKSNNMLGTYEYPDFPLDGATYGVKPGQHIPGTVLHQYLTDYAKKFGVFQRIRFNTRVTSAEPSEGSGWLLRTASAEGKVFQTKKLVIATGLTSEPYVPKLPGMEEFRGQMFHLRDFAGKADTLKDAQNVVVVGGAKSAWDAAYAYAQAGAQVDMVIRKSGHGPVWMAPPYVTPLKKWLEKLVHTRFLTWLSPCVWGDEDGYSSIRHFLHGTLIGRGIVSTFWKILGSDVISLNKYDSHPELKKLKPWDPAFYIGSSLSIHNYPNSFFDLVREGKIRVNIDEIAGVSSESINLASGQKLKADVAVLATGWRKEPSVEFVNGSEAEVGQRHSPADLEALTKQADHEILERFPSLKTQPERTSQLQEKLAERMGQPLRLYRFTVPPAMVAKRNLAFVGMSSSITTPIVATVQALWISAFFDNKLDRLPESEDDIKWETVLHSRFCRWRYPIGYGPNFPDFVFDAVPYVDMLLRDVNLESHRKPGKMADMFDPYGPEDYVGLVDEWKKGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z1V9</accession>
    <name>A0A0D1Z1V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241862.1">
        <property type="nucleotide sequence ID" value="XM_016376586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z1V9"/>
    <dbReference type="STRING" id="91928.A0A0D1Z1V9"/>
    <dbReference type="GeneID" id="27329309"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02226"/>
    <dbReference type="HOGENOM" id="CLU_092676_0_0_1"/>
    <dbReference type="OrthoDB" id="4119977at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946:SF4">
        <property type="entry name" value="COAGULATION FACTOR XI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237408" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="246" mass="25297" checksum="7A63BB5515C96D27" modified="2015-04-29" version="1">MLFSRTALVASLLGVANAVPVASSLSCVDDASDGQSYNGFVVQCGIDYNGNDMGLAWTSTFEDCIDTCASTSGCVDVSYSGTACYMKSGIGVYTINGVWGAVKAATSTLTCPSADGQVYDGFTIACGIDHVGGDLSNFYAGSLNSCLDTCSTTADCLGVAYAAPYCYMKSTINEPSSNPAIIAATLPPSNTGLCANGNTGTSTYSAGGKSFNVVCGWDYYGYDISNQQTKDLETCISRLLAGPIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z9Q8</accession>
    <name>A0A0D1Z9Q8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_12055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847504">
        <property type="protein sequence ID" value="KIW09712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229928.1">
        <property type="nucleotide sequence ID" value="XM_016386362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z9Q8"/>
    <dbReference type="STRING" id="91928.A0A0D1Z9Q8"/>
    <dbReference type="GeneID" id="27339138"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12055"/>
    <dbReference type="HOGENOM" id="CLU_443452_0_0_1"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="281"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="616" mass="69085" checksum="6B7C1DB8121F60F6" modified="2015-04-29" version="1">MAEAVAIIGLVSSIASLFELSVGIVSRLHDFTSKTSEVPESFRSLTIRLPLLTETLQRIQTQANSHRLPDDVTKALTAVVRNTSEQLLAIQTRLSKILPSDSASRLERALKALKSLAREDEIQQALEKIEKNISVLVLYQTTGHVDTGDLILAQLSELTMISKSASRSFGKDELLSLARATGKTILEELSPQTQSIISNSNRGLLFRFSQLPIAAQEKFIARQEKELRQFVEQEEAKVLEFLTGFDTRDRLADQGRRRAEGSCDWILESPDYLNWVGGNCNRLWLLGGPGSGKTVVSAFITEALNNGLRREDVLAVYACSFTDSQTTSATNILYALAAQIAQSSLACMEKCKRFLERHLSEGKLKAEIQDLQDLIVEMSLSTDIQRIFIVIDGLDEVEWEQPDHLMVIVDIPQYARKVKMLITSRPCPRVAKALQGYSTLSMNDVTFNDALAAFIDGELKRSRLANIPQHDFDELKESLIRTSNGMFLHAQMAISLLSESYQNVRTFQQTKEALLQDLPKTLEEVYNLKMLTIQANNSAIDATAVESYLRILAANPEMDPLTELHQAAIQECPDVPYYTPEDLAERAQGLLKWDPESRRLRFIHLSAIDYMLLHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z9V6</accession>
    <name>A0A0D1Z9V6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_11898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230013.1">
        <property type="nucleotide sequence ID" value="XM_016386205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z9V6"/>
    <dbReference type="STRING" id="91928.A0A0D1Z9V6"/>
    <dbReference type="GeneID" id="27338981"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11898"/>
    <dbReference type="HOGENOM" id="CLU_031281_2_2_1"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002247649" description="FAS1 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="171"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW09797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="377" mass="39258" checksum="F134D07B9871E822" modified="2015-04-29" version="1">MTITGLLLAALAGTAIAQSSDLVTVLNSTNGTATFSEVLAEIPGFLEAIAGKTNITVLAPNDTAIAELLASPAGQALEDGGADYALNLVLYHVIDGGYENITDYAVVPTLLTSSNYTNVTGGQHIGFYWDDDEDVVGFYGGNDFAPEASHTPIPFDQGWIYVLNGVLQIPPSMSETVTSGDFNGSSFVAALEKAGLKEEFDLLHDATYFVPVNDGFDAVEDALSKLSTEELAEVLKYHVVAGKVWDFELLEKVSQVTTLQGKNLTVTQTPDEEWFINQAGIHYTDLAVAGGVVLFIDNVLNPLAADFAAPRNGTDGEGLPAFTVTNATSTSGTNDSTSSTASASPSIASATSTGLAAMPLSVGISTLIGGIAVALLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAX2</accession>
    <name>A0A0D1ZAX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1742-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230378.1">
        <property type="nucleotide sequence ID" value="XM_016385434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAX2"/>
    <dbReference type="GeneID" id="27338206"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11123"/>
    <dbReference type="HOGENOM" id="CLU_088285_2_0_1"/>
    <dbReference type="OrthoDB" id="2158714at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21687" checksum="85A3AD987B0414CE" modified="2015-04-29" version="1">MSLPFANVYHLRTVAEASSKACFVCYKPSVKVLITPDNKDFFYICPSHLSDRGFASPVVDAEAEAAKKKKEWREKEIEKVKQEYEEKQKKKKAKKKSKDDKDKKKDNDDDDDDDDKAEKERDEKIKALQAGEGLGSKAEDLPRVYALQKNFFQMRIDRQRNMEIAKRNQQRIRDPNFFPAPPRGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZDI7</accession>
    <name>A0A0D1ZDI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_10316</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231233.1">
        <property type="nucleotide sequence ID" value="XM_016384631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZDI7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZDI7"/>
    <dbReference type="GeneID" id="27337399"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10316"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075018">
        <property type="term" value="P:positive regulation of appressorium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW11017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="357" mass="41238" checksum="1404B20E3B584BA7" modified="2015-04-29" version="1">MGQPQQQSAPSGGSRKISFNVSDQYDIQDVIGEGAYGVVCSALHKPSNQKVAIKKITPFDHSMFCLRTLREMKLLRYFNHENIISILDIQKPRSYESFSEVYLIQELMETDMHRVIRTQDLSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSAASTDDNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQLTLILDVLGTPTMEDYYGIKSRRAREYIRSLPFKKKIPLKALFPKTSDLALDLLEKLLAFNPVKRITVEEALKHPYLEPYHDPDDEPTAEPIPEEFFDFDRNKDQLSKEELKALIWNEIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZF54</accession>
    <name>A0A0D1ZF54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_10909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231823.1">
        <property type="nucleotide sequence ID" value="XM_016385221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZF54"/>
    <dbReference type="STRING" id="91928.A0A0D1ZF54"/>
    <dbReference type="GeneID" id="27337992"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10909"/>
    <dbReference type="HOGENOM" id="CLU_016574_6_1_1"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF24">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW11607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="489" mass="55877" checksum="64575E4B815BD006" modified="2015-04-29" version="1">MAETRVKAAPVRAGFAQACDARRRRKVRCDRSEHCKNCVHAGLPCVYSDRKDAARSRMSIVRGGVIAMCKTAKDQQRHASVTSIRTNSTSTSTQALLSMFPKTYFLDLINDYYTYVFPTVPVIGREEFRQAIRNMACSNHDTALVFCLAAQTIYLSRAFSSRPPVTKDDVRTLFEMTLRAREPLLSVQQITSASVLVSLLVSTGMIDTFKDQAMGTYYNREAIAGLQALRVDDSEHQSSLEPQVAAQRERLYWIVFIHDRYHSLQNDQLSNLPPLAFCTPQGLGDVPPDTDTWLDQEVRLFRVVDDDFLRFHKDKGDPRLTREWIVEKQLQLGSDAEAWIQTVQQFSELQQMDLIVTNYWLRTVLWRIALFRFPLMSNQGDAHQRILTLEYPMHLSRPLRHLLTTRSRAAVEFHGEGMLQKLFDITCTVADVLLNVLAHTWDVGTRSAQLENFVFLHAFLLGMSSLPEAKRRVLHEKMGEVQTVFPEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZH05</accession>
    <name>A0A0D1ZH05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232448.1">
        <property type="nucleotide sequence ID" value="XM_016383825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZH05"/>
    <dbReference type="GeneID" id="27336591"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09508"/>
    <dbReference type="HOGENOM" id="CLU_026673_29_2_1"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF19">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="25"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="352" mass="38151" checksum="AA2E261DFA7B03C1" modified="2015-04-29" version="1">MSELPTTTRSWILTNKPTSLPTISGDEPTFTLQTRDLAPLEDDQVLVKALYLSNDPAQRGWISADVPKDRLYVQPVEVGEPMRARGLCEVLDSRSKSIAKGALVLGVCNWTEFAVLDAATVTPLEPLPNGLSLTHYLGALGTTGITAYYGLVVVAEAKKGDKVVVSGAAGATGSMVVQIAKHIVGASNVIGIAGNDDKCRWVESLGADKCLNYKSPTFAEDLKDATRDGVDIYFDNVGGEILDLMLGRMSMYGRVAACGAISQYNSSEPLALKNYFQVISMRLQIRGFILLDYLQKRAEALQVFRQAIQDGKLKIGEGNQTVVPTKFEDVPKTWLKLFSGDNTGKLLTKIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHM2</accession>
    <name>A0A0D1ZHM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_09689</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232628.1">
        <property type="nucleotide sequence ID" value="XM_016384005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHM2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZHM2"/>
    <dbReference type="GeneID" id="27336772"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09689"/>
    <dbReference type="HOGENOM" id="CLU_010026_1_0_1"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW12412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="61712" checksum="C9BB591AADB4EA4B" modified="2015-04-29" version="1">MDAVDTPAPQAVPAKREPPPEKPEAVSLRTKIVFSFWAVIILLGVPTWWQTTSIYRANLPLQEMVDWADGLNTPTSIPLHIWVEAPSLSCLDAQRLVQDTQQALDDLNEYPTLHQRLHLVRGSWKDESGKGKEQHSGCGEDATNPVLGEPSLKILLEPAKDSFEFKLDPVAATAVVRGPIPHIPKQLADKVQDLFKDEQIAAALQVVSLAGHTNYAQSFLRSQSIEHVSTIEKRISRAYKASPEFHLTFSLFTATESPSSWDVQEALKDSIYPLVQALSNIAKIGITTQVQLYSAFSPAVQPIFVEGYNGTLLPQKDLTAFVNAAEWPLAPSIGEGPTLNFILYVPSPDQIPLAIDGSEGTSWLIPQWGGIQILNPDLTINSVSGKFTPPSHLNREILQLPFQTFSSQLLSLLGTLNSEESTKNLPLQLRLDAYKRFSALTLYLKAASSLGSLSRLAQRLSNIPIPKHVAQLIDDTIGNLTACCHAFQDSRWDLALSHAQTAYQDSEKAFFDKSMVGQVYFPDEHKVAVYLPLLGPIGVPLIVGLIRELKRTASKSKVVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIK7</accession>
    <name>A0A0D1ZIK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232908.1">
        <property type="nucleotide sequence ID" value="XM_016384285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIK7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZIK7"/>
    <dbReference type="GeneID" id="27337053"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09970"/>
    <dbReference type="HOGENOM" id="CLU_009184_1_0_1"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="225"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="730" mass="81369" checksum="51D5E30F408AE84D" modified="2015-04-29" version="1">MGANQLLGGMNDSYGPYSAVPGQLQEQHGPPNCDQIISIDQNVSPFGSTFDNTDFTSNLDWFLEDAGANNFLATPDFFGLFGFNENQSLHDPLMSAQQTAVPSARQSDAGGDDYVAMGDTREGDTSDSAPALGGLLTPRPQETGTSDNPWPVENPRPSQSHTILPGLGPEDQTPKSFSKFYSLVPVNDRTRQALVKCIMFPFEHSSTQTLNLDHFPNNETLDHCIDLYFEYFHPMLDVVHRPTFDPGRDLVVTLAMICIGSCYTGQPGAKSFSIALSELIRKLLVFMAEQDRRFVRTASYLTAQLLQGTHGYCSGSERLFEISESCRSTLVHHAKCMGLFRYESQHVLRPGNSQEEAWREWVREEGLRRLGWAVYKYDASVAYLHNNRPFLSIGDINLSLPSSTEHWSAESAQAWSSLHPWSTTCPPTSRLRPMIRLLFDGTTNPVEKIEDEEHCFVILLTLLRMLWTLKEIRSSPINDLVTPPIYDDGRLSLIHAIDKFAVAIVAASKNHTRSEINRLVHRMQLVHISHIYGAGDLMNWLYPYLRHGPEAENARTRMKQWANENAQRIRDVVFHCAQILALVRRYPSNMSLEPFLTFHAGVVLSCMALLLPTAVPLPQSPPILVDLLDSENREVTNRQSTWISQGGNERISLHGVPDLACALGRQQVLDQTALLLKRQRAWGMAANLSKVVLSLGARDMNDNTQAAVDSPQLLLASPSPPGIPLGLEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZK74</accession>
    <name>A0A0D1ZK74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233448.1">
        <property type="nucleotide sequence ID" value="XM_016382745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZK74"/>
    <dbReference type="GeneID" id="27335502"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08419"/>
    <dbReference type="HOGENOM" id="CLU_086085_0_0_1"/>
    <dbReference type="OrthoDB" id="4156944at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="275" mass="31484" checksum="6C46D0401B977635" modified="2015-04-29" version="1">MKKPVMNRRNRPLTFQSNRSVDDIRNPASPKSVSFTSHDHNRSGRGSAKRGSHRISKVKDNDTNPSPRQLDRYRSSVHDAVTKDFDNVEKNLLTSLEELSVDFDNHIGKLTSIEEPLGKPFATETLSILKEGDEQQQEVLLQDQVAAFRKLRADKEEILRRLWEEWEGTQLQLIGLAAEVLGQDALTFAQVRDEDLKPGQREKLQSTLTNAQRLFDKKREHQEGLQQHLGAFEENIGQIASKTEKTVVEMQQQYNTQKSKLFKGLHRHIELLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZKS2</accession>
    <name>A0A0D1ZKS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PV08_08615</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233643.1">
        <property type="nucleotide sequence ID" value="XM_016382940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZKS2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZKS2"/>
    <dbReference type="GeneID" id="27335698"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08615"/>
    <dbReference type="HOGENOM" id="CLU_007713_2_0_1"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001377">
        <property type="entry name" value="PRK00278.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="18">
        <location>
            <begin position="27"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="19">
        <location>
            <begin position="252"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="571"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KIW13427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="763" mass="82324" checksum="17997E96E926E06E" modified="2015-04-29" version="1">MAASDLIDHSPHQPVAAEKLASASNLVLIDNYDSFTWNVYQYLVLEGATVTVYRNDQVTLDDLIAKNPTQLVVSPGPGHPDTDAGISKDAIKYFAGKIPIMGVCMGQQCIISVFGGKVDVTGEILHGKTSPLRHDGMGCYTTLPQDLPVTRYHSLAGTHPTLPKSLEVSSWIAKGPDSGKGVIMGVRHKEYVIEGVQFHPESILTENGRVMFKNFLRMTGGKWSENPQVASPAKETNGVTNGHPPAKKESILEKIYAHRRKAVAAQKLIPSQRPEDLQASYDLGLAPPQISFPKRLRQSAYPVALLAEIKRASPSKGIISLGTCAPAQARKYATAGASVISVLTEPEWFKGSLEDMRAVRQSLDSMPNRPAVLRKEFIFEEYQILEARLGGADTVLLIVKMLDVETLTRLYNYSKSLGMEPLVEVNTADEMKIAVDLGAEVIGVNNRDLTNFEVDLGTTSRLMDIVPKDTIVCALSGISGPQDVQAYRKDGVKGVLVGEALMRASNTVDFISKLVGDPSVESSEIVQAPLSVKICGTRTPEGAKAAIEAGADSVGIILVPGRSRFVSDEVALQIAKVVKTTPKPTRKSAHAPDVGSTDFFDHSSRLLVRPDRAQLVGVFLDSPLEHVIEQVYKLGLDVVQLHGSEPIEWARNIPVPVVHKFSPHDHGISARGYHALPLLDVGVGGTGKQLNVDEVKAFFDKDPSVKIIFAGGLNPDNVESILKSLGPYRANIAGVDVSSGVETSGKQDPSRISAFVKAVKSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZLB8</accession>
    <name>A0A0D1ZLB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233823.1">
        <property type="nucleotide sequence ID" value="XM_016383120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZLB8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZLB8"/>
    <dbReference type="GeneID" id="27335880"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08797"/>
    <dbReference type="HOGENOM" id="CLU_023417_2_1_1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="507" mass="56985" checksum="8375AB73E013F44A" modified="2015-04-29" version="1">MTIAAPFRGTYKLRPNYPRTKTGCLTCRHRRKKCDERRPICRGCTRNELRCLWKDPSHSRPPGPYIDQAHGRKQCVLVVADDPNQAISSAPALQPPDLVLRLPPNQLHYASDRACALTSVSLGLLSHYIIHTGALLAAAPLEHSPFITQLLPLACLDDTLMHAILATSAAHLSFKNNGEVEIDMAAWKHYSSAIQSLQRQCANLCAMDPEKTLRLLVVLIVISHFEALSGNCNGTIFMHLRACRVLIHGFLNGHIAPLTGDCKSLFGFSIEIYAYLLFSNTLTPYGMLQERTLPYDSFLMSLDVLTQYQTFGTMFAGAHGLFQLIPLLSLLHSNRLNEQEVGEVSESSILISNQLYDLILHWDLSECEDDCDGHEASRRQLAAECYRYALEICLLTAMAGTEVTDITTIYRIETLTRAIMVTVEQLSGSSYCASMLWPLMIAGSCMINYRHQNKLEEMLRNSRYQMRHTVSAAELLCLLWKEDSQHVYGPYGLSVVMKKYNMNCCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZN73</accession>
    <name>A0A0D1ZN73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234513.1">
        <property type="nucleotide sequence ID" value="XM_016381411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZN73"/>
    <dbReference type="STRING" id="91928.A0A0D1ZN73"/>
    <dbReference type="GeneID" id="27334162"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07079"/>
    <dbReference type="HOGENOM" id="CLU_122933_2_1_1"/>
    <dbReference type="OrthoDB" id="3709982at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="90" mass="10643" checksum="C80CB3020151EC91" modified="2015-04-29" version="1">MQRTIEPRRIVLRFRVGYELEEAAILHDFFTTINLNPGDDYFSHLMAPYHEESTVMHIILDMYCRTNPTVDLETMAYGVFKVKKNTKLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZNQ6</accession>
    <name>A0A0D1ZNQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_07231</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234663.1">
        <property type="nucleotide sequence ID" value="XM_016381561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZNQ6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZNQ6"/>
    <dbReference type="GeneID" id="27334314"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07231"/>
    <dbReference type="HOGENOM" id="CLU_171977_3_0_1"/>
    <dbReference type="OrthoDB" id="44067at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW14447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="70" mass="7969" checksum="F2AA4D63BF9A2EAF" modified="2015-04-29" version="1">MSLGARFSSGLFNGIFRRNAVFLTSVFAGAFAFELAFEAGTNTLWDSWNKGRQWKDIKHKYITADEDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQQ8</accession>
    <name>A0A0D1ZQQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235343.1">
        <property type="nucleotide sequence ID" value="XM_016382241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQQ8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZQQ8"/>
    <dbReference type="GeneID" id="27334997"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07914"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38310" checksum="78E2DFE9C8261BDA" modified="2015-04-29" version="1">MASLKHVFDRSTTGTSVAEIFSSAIKGKTILITGINKGGLGGKMVEILSVHSPKTLILASRTPSKIQEIIDTWKAGSPNTTYIPVALDLGSQKSCREAASSILSNTQIQQIDLVFNNAAVMSLPQREFSPENIERQFATNHIGHFLFTNLIMPKIITAAKASPKGTTRIVNVSSRGVVYSPVRFTDINFDKVNETLPEAEQPAYEALASTGRHVDKKDRYSPEVAYGQSKTANVLFSLALTSKLYEKYGILSFGLHPGAIMTELARHMDPEKFAAVAERFKNMFVSVDQGCATSLRAGLDDSLDPADFKGDGKGIFLADAEIADAPAWAHDPKLAARLWDVSENLVGQKFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZRK5</accession>
    <name>A0A0D1ZRK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Erythromycin esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235628.1">
        <property type="nucleotide sequence ID" value="XM_016379801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZRK5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZRK5"/>
    <dbReference type="GeneID" id="27332541"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05458"/>
    <dbReference type="HOGENOM" id="CLU_354511_0_0_1"/>
    <dbReference type="OrthoDB" id="5204833at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="792" mass="85288" checksum="38FA4C5E6D54110F" modified="2015-04-29" version="1">MATPRRRSARLSKNAQPQRQSARKQGAATLGSLIERDETPEVNEPQSLDEVVATPTSAVTTKSQLAMLSGLKTPKTEPRVDRGEMHPEHAHQTTTKAPDSGLKLGFVDISSRPRTIASAQNTPSKARTSTPAHFQSTSVDFKFGAESQLSTEAQKLMDNVREEAASIKAQMQAERDAQQEKDDKAEAEFNGVNASGRKIAKPKGKAGRFSDIHMAQFKKMDSIANHPSAFRGKPSFAQPTTQSLKRSGSKAGLDENERPRTAGKGTPARRPPPPPFLGRPTSVSPFKSIPSQSERIENTTPAKRARHSELHDVSASRPVEPAQPLRTVSKPMSSNLFSPTKASLARAAASQIPVSSPNKASSLKRPASVKSLRTASSTPGVRPATAHGASYAPNPSKAPSADKARLNRPLPPPPENESSLSPSPESAKVVQAEPDVQGSSALKHHGFSSRLPKFNGLKSILRTGRRTDIMPPTQERQGTPKRPATATTGSGDVKKVDFTPSVKSRYAVKLAAGSPSPAKLPTQLTPGKALGPLVAYDPAAYVLGDDDGDDAWEDAESEIDYPVLPAMSSSPAQPVSGTTFEKKAKEHSRRASKEFKSIFTTLHHPSRPTQPSNLASVNARVNKSGPTAHVDKIMRSPSNTNFSRPSPSTIRRVRTSGAPELVQPFEDAEVQTVPHGIPGKKRRRESTASNEDEDSFEPMGKENRRISVMPSVPGGWCDTPQPEEQDEGQQRGGKRAKVGSSTTSPEKPQTEVKKPRQSMAREMAKKSADARKGKGILSLSRLNMLSRPKQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZRY1</accession>
    <name>A0A0D1ZRY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235728.1">
        <property type="nucleotide sequence ID" value="XM_016379901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZRY1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZRY1"/>
    <dbReference type="GeneID" id="27332641"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05558"/>
    <dbReference type="HOGENOM" id="CLU_1261348_0_0_1"/>
    <dbReference type="OrthoDB" id="4159459at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237865" evidence="1">
        <location>
            <begin position="18"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="245" mass="24379" checksum="5DFFB3011E3F929C" modified="2015-04-29" version="1">MRTSVAVAAGLVAAASAKTYSVTVTDDVTITSCPPTVTNCPYAAATSAGPWDDWTSSTTATVDPITTSTGDVTWGDWTTTTSSVPVSPISASSTTDPAWGDWTTITGSSSVPVSPVSTTSAPCPSYTATTPPAWFSLLPTEVLSSIEASWTGAPPADWCYYTYSTSSVATSASTPVGPIVTSTGSAYWPVGPTSATPVAPASTGAWSSYTPSSPVSPATFTGAASANAGSFAFAGLVAAAAVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZSH4</accession>
    <name>A0A0D1ZSH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_05832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235998.1">
        <property type="nucleotide sequence ID" value="XM_016380171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZSH4"/>
    <dbReference type="GeneID" id="27332915"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05832"/>
    <dbReference type="HOGENOM" id="CLU_014819_1_0_1"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW15782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="574" mass="61963" checksum="AA61B50068A8E4C4" modified="2015-04-29" version="1">MAVMEVFNYLYERTAETLRPRATGSSKEVGETVVKTIKMLVQRFAVALAWLSSLSQAATFEQQCAQFSSQLQLDNATVWFSEFVAAGTNLTLSQNNVTCARPSQVVEVDLCRVALYVATSNRSGISMEAWLPKNWTGRFLSTGNGGISGCIQYEDLAYTTSLGFSTVGANNGHNGTGGHAFLDNPDVVTDFGWRSIHTNVVVGKQISQAFYGKPHTKSYYLGCSTGGRQGMKSAQAFPDDFDGIVAGSPAIRFNGLDSWSGNFYPTIRDAGPEGFPPNTTWAAIDAAILAQCGTGAVGDAPDGFLENPDLCHFRPEALVCPTLSANVSSCISGAQADTIRAIFSPLYGVNGSLVYPQMQVGPGILEAIYAIYGKAQFPYTADWFRYAVYNDPNYDIDHLTPKDWAYAERLNAGETNTFDGDLSPFQSKGGKLLTYHGQADPIISSANSPTYYDLVSRTMDLPSTALDDFYRFFRVSGMGHCSGGPGATFIGNVGAAVASLDPDQNVLMAMVRWVEQGTAPDTILGTKFVNDTASLGVDFQRAHCRYPFRNVYVGGGGENATTDAWKDPANWVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTI4</accession>
    <name>A0A0D1ZTI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="11" type="ORF">PV08_06138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236303.1">
        <property type="nucleotide sequence ID" value="XM_016380476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZTI4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZTI4"/>
    <dbReference type="GeneID" id="27333221"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06138"/>
    <dbReference type="HOGENOM" id="CLU_032162_2_0_1"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003591">
        <property type="entry name" value="PRK05254.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="10">
        <location>
            <begin position="131"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="318"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW16087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="400" mass="43571" checksum="5AA5C26E94A4355D" modified="2015-04-29" version="1">MSFKRKAPPTSAGDDAKKPKKNSDLTSFFGPPKVKTATATNNGGLAGGGGVVAESAPTPKFDKDKWASGLSEEQRRLLKLEIDTLDPSWLAQLKDEVTSNSFLELKRFLQKETASSQKIYPPMEDVYSWSRHCPLHKVRVVILGQDPYHGHNQAHGLCFSVRPPTPAPPSLRNIYTAIKRDYPSFSPPPKSAGGLLTPWADQGVLLLNTCLTVRAGQANSHANHGWEKFTQKVIDTVVKLRTRGVVFLAWGSPAQKRCAGITGARHLVLKSVHPSPLSAHKGFFECGHFKKANEWLESRYGPEGVVDWNLDGNKSVPMKGPAKDVQGPVKVTEDQVPSPKEDGPVTEMVENGAGWNGEKKDDKDEFEGDDDDDAIAALEEVARLEAEAEAAAHGTGKVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZV87</accession>
    <name>A0A0D1ZV87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236858.1">
        <property type="nucleotide sequence ID" value="XM_016378181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZV87"/>
    <dbReference type="GeneID" id="27330913"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03830"/>
    <dbReference type="HOGENOM" id="CLU_1421435_0_0_1"/>
    <dbReference type="OrthoDB" id="4713722at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="191" mass="20289" checksum="D2272CB5C8F15F48" modified="2015-04-29" version="1">MPGRRLNEEGVIKALCEMVATATEFKVDAGAMQAHFGVQVERTIHRKIDNMIEPYGYRFRGGKVEKRPPPTAATVPAAAGPAPATGVAPAVVAPVVAAAAPAPAPAPANDNDGDGDDDDEDVDVDDNDNNNDDDDDDDEGQDDMANEEIIKKEDDDDIEMADVKDEADDDVSAGPSNVKEETDVVIKTEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWF8</accession>
    <name>A0A0D1ZWF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237213.1">
        <property type="nucleotide sequence ID" value="XM_016378536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWF8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZWF8"/>
    <dbReference type="GeneID" id="27331271"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04188"/>
    <dbReference type="HOGENOM" id="CLU_009538_0_0_1"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="81453" checksum="C6D502C10D779F2D" modified="2015-04-29" version="1">MSVHRRQTSLNSSASAASSHTSGASAASTSTPTSALAAAFSFAGLNFRSHAAKAALLTLTPHHLFYLLSRMEELDILVGPMNIRLENLHTDPSPSNYVSFLQSHKPSKGRSDRDSIHSVSSMRSVMSGMSTFWSSIGLGASTSKSEKAKALAEADLTYLYSAFTKLPSLRLTTDHRARLIQGYEEFPFDTAVPLFAFKNLQQLDIVDLDFRQFYGWDRLAEQLTLLTVKRANLDDPAELLTDIVLDDAEKRRRRSTKGGRASPTPPNLWPEVATPQAGYTHPHSDPGSPIGASLEHDDHVDFMPRDKQMSGSVSPKRPSPGRPTSSSYRHVRTYSSKVKRSGSGSSNSSEYSVQPHRSDSTSSLLSLNILAPAKWQRLKYLSLADNSLTTISARSLAPVATTLRSLNLSSNLFTEIPDSLASLTRLVSLDLSNCMIGSLQSLSKYPLPAVLTVNLKANRLRSLAGIEKLLSLEQLNIQDNKLSDPMDMARLTCIPNLKRIWVKRNPFTKTSSDYRVLTFNLFRKTPGYVDDIVIDESGPGYSERKQLVDRVPEVERQIAPPSIRIVELPVVVQHSEQTQQGHSQQTESVVNTTRRKKIPRRRIVDLAKDEAFARLPDEDLAATIPFPPTVTDHATVTVDENPPQLPVSSPGETAEEDLYDGSTRVASVGSSTQAIQEDDYRAKVEALRQEFGSNWLSVLGDQNWHNNHHMEITQGQTNLGHHSLHRPGPVIVSGGRTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWJ1</accession>
    <name>A0A0D1ZWJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237248.1">
        <property type="nucleotide sequence ID" value="XM_016378571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWJ1"/>
    <dbReference type="GeneID" id="27331306"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04223"/>
    <dbReference type="HOGENOM" id="CLU_011910_2_0_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="285"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="679" mass="75390" checksum="50064B58BAA02C24" modified="2015-04-29" version="1">MLLNTLDAMTENHVYQQSGGDSTASHDNLSKAKDHAAKQLDPERLRWPQIAGEGSSLNRPGAEQPNASSRAGSLNTIGELSSVVNLAQGGGASGLVGHMSEVAWIDQAFAVVRGRPDATRPRLLTSGVLDPHVFSATNFIYFVDDNEVLAVNEDRIDPYQRPSFSRSLILTEAYFHALQGAFPFVVRDEFLANLFDMSTPQHSWRGRRQLAKANMIWAIGSKWLEMTGMNGEALSPTDTHPHYYARARALGLDHRVVFDHPNIDQVQAMGLLALYLLFNGSVTRAWNTLGCAIRHATALGLHLQVTDPSVSNEDLRRRARTWYSLYSLEVLISEITGRPKSISVSDVTAPIDLLAGPASGSTRSTSLDDSTRSVPPVPISTTQVGEPILLEISRKAWLEHLKLMQNNNTATSSSSSSSLSPGLTIGDDDDHAIPTTYLPQRLHLCLLSDKIARQLYSGTNDPSWLGLQRRIHDLEAELRRWVETLPENLSPASSPAGRGDEFLNPRIRIELAMYYHSLQMILYRPCLCANSAEAEAVESREFNHRAARACVLGALSMLALLPDVPTIKEIYRLLPWWSLLHFVAQASAVLHLELAIDAQHFEGEVDKLVESVAKAMRYLHCMAGASLSAYRAWKIFRVLLNEVSRRYHNMDLNDFAQDAPRPHGWTEEVEKVMCVWPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZX13</accession>
    <name>A0A0D1ZX13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237453.1">
        <property type="nucleotide sequence ID" value="XM_016378776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZX13"/>
    <dbReference type="STRING" id="91928.A0A0D1ZX13"/>
    <dbReference type="GeneID" id="27331511"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04428"/>
    <dbReference type="HOGENOM" id="CLU_019692_4_1_1"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000054">
        <property type="entry name" value="DCR2p Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="215"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="543" mass="61370" checksum="76A0EF1F09749E84" modified="2015-04-29" version="1">MTRRLFRTGIQLAVIATVVLFTVIFIDNRYRVLPTSIHNHLPAHHPGFVVTDITVVTCSSLNPFSSCTKDGPYWHRINKDLYLNKGYLSKAYLLVERKRDTDLKPHEEVVLDIKVGRIQPSNVGVNSKDERWESRPAGIWIKKSAKRNDDHKIVTGVDVLFGADAADPRSNWNILDISLFIDGGSNTAEPRLTVRKGPAIRVEKPVPRIRKDGRFKIMQAADLHLATGLGECRHALPGGSKCEADPRTFEFLERLIDEEKPDFVVLTGDQVNGDTAPDSQTAIYKYSELFARHRIPYAGIFGNHDDEGNLDRAASMAIMDGLPYSLSTAGPEDVDGVGNYVVEILGRGSTSHSALTLYMLDTHAYSPDEHKYHGYDWLKQSQIDWFKTTSQHLKRKHREYTHIHMDLAFIHIPLPEYRNPDGLKWVGNWTEPPTAPAYNSNFKDALVEEGIVMVSCGHDHVNDYCLPALDKEKKKPALWMCYGGGAGFGGYGGYYGYHRRVRFFDFDMNEARITTWKRLEWGDTKSRIDEQIIVDGGKVVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZX19</accession>
    <name>A0A0D1ZX19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_04433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237458.1">
        <property type="nucleotide sequence ID" value="XM_016378781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZX19"/>
    <dbReference type="GeneID" id="27331516"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04433"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW17242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="575" mass="61756" checksum="90B66E822D4F63BF" modified="2015-04-29" version="1">MAREQQYQLEDQENLLPKKQVIIVFSALACILLVTFIDQNSVGVMLPTIGGDLHAENTISWAATANLIANTTFQVLYGRLSDIFGRKGVLLTAIVLLAAGDLGCGFAQNGPQLYALRGLSGVGSAGITALSMMTTSDIVTLRERGRYQGILGSCIGAGNIIGPFIAAAFTETATWRAMFWFVSPLAILAGGIVLVVLPQKTPGGSFMSKVSKIDFIGSVLSTAGMILVLIPVSGGGTYFEWRSVMVIVMFVLGGLCMIAFVLVEWKVAQLPTMPIRLFKNRAVCVILVQNFLFGSVYYSILYYVPLALQNVRGLSPLASAGVIVCLVFAQSISSVASGQYISRRGRYGEVLWFGYGVWTVGAALFCMFTRSLPIAAMAVFLLIEGVGVGCCFQPTLVASQAHCVKADRAVVISARNFCRTFGAATGLAICAAIYSNVLQADLPASLPESFRQTVTSSIFKTPNLSVLNHEQRDGVLDAYAHAARAVFILWAPVMFVCFLSMVFVEDKGLERPDEKKSDPVQVQADPVLEDSVVTVSPDDVQDSASHHEKKDVGIGRVEASNLDETHGKGGNREEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZY57</accession>
    <name>A0A0D1ZY57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pre-mRNA-splicing ATP-dependent RNA helicase PRP28</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pre-mRNA-splicing ATP-dependent RNA helicase prp28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PV08_04762</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237783.1">
        <property type="nucleotide sequence ID" value="XM_016379106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZY57"/>
    <dbReference type="STRING" id="91928.A0A0D1ZY57"/>
    <dbReference type="GeneID" id="27331845"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04762"/>
    <dbReference type="HOGENOM" id="CLU_003041_11_3_1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="389"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="605"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="107"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="762"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="794"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KIW17567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="808" mass="88803" checksum="C58B7140163D32AC" modified="2015-04-29" version="1">MATGMVNGHDADIPAPPVDPISRPQTPPPPPSTLAPPPPPPSDLAPPPPPPATNGAVVKKKGWGASTKPKSQPLSVEDLLKKKREADLAASKPKFLSRAERERLALEKRANEVEAAARAKSQNGHNGTPPLEAPQDAGRSKSSVAPTGPRAFRNGEVPTGPSAMRSKERNRGVDFTPPTAPKSISFGADSRTQKRQADEDRTGKAEVDLIRQRYMGAETNVSTFSASKKRRRTTEKKFNFEWNAEEDTTPDYNPIYKERAQPTFFGRGRLGGFDQQAADEAARKYAEALQSRDVEAGAARAQEILEMERRRKEESSRMAVDKHWSEKRLDQMRERDWRIFKEDFNISTKGGGIPNPMRNWKESGLPRRLLDIIDQVGYTEPSAIQRAAIPIALQNRDLIGVAVTGSGKTAAFLLPLLVYIAELPRLDEDEWRRNNGPYAIILAPTRELAQQIEIEARKFASPLGFTVVSIVGGHSIEEQAYNLRNGAEIIIATPGRLVDCIDRRIIVLEQCCYVIMDEADRMIDLGFEEPVNRILDALPVTNEKPDTDDAEDSRAMSRHLGGKDRYRQTMMYTATMPAAVERIARKYLRRPAIVTIGNIGEAVDTVEQRVEFVAGEDKRKKRLNEILQSGEFRPPIIVFVNIKRNCDAVARDIKSMGFSSVTLHGSKTQDQREAALQSVRDGKTDVLVATDLAGRGIDVPDVSLVVNFNMATNIESYTHRIGRTGRAGKSGVAITFLGNEDTDVLYDLKQMLMKSSISRVPEELRKHEAAQQKSQRGGHGGASKKGITASDESGGFGGGKSGGGGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0S1</accession>
    <name>A0A0D2A0S1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA splicing factor CLF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016377203.1"/>
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    <dbReference type="GeneID" id="27329928"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02845"/>
    <dbReference type="HOGENOM" id="CLU_013054_0_0_1"/>
    <dbReference type="OrthoDB" id="5352000at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="84630" checksum="DABCDB885D4DAAC1" modified="2015-04-29" version="1">MSAPKPPVALKNHCSIIHDGIIYVYSPDAFQTLELKEGAQWQQVENGVAVEGAACVKGGVDGDNSKTALYVVGGAANASSSDYPGLQRFSISDKSWQTITPTVKVTQNRLNHGAVYMNASSSILVYAGSQVTGYDGLSSETFVLEMYPPYRVLAYSSIAPPTTKPIMLPWGEDRAFMAGGSSTNTDIFTFGPQDGWQNLGLSLPDPLPNSSVAQSAILTLDDNSRILQTFNLGQDVPNITSNVLLKAGGQLADFGETVGGSTPTPTPIPFTSSGSKAKRDVTLATYPSYNDSLAPSTSRTDFDLVQGDDGLVAFVGGSTDSVAFFNQTGDSWISTTSLLGKQQEPLSSPSSTQSTSTATSTPTSAPGSSSHKTNGLAILGGVLGGICGLAAILIIILLWLRSVRRKREKAEKQSGYGDDKKRSGEYNFEEQGLQPLARQGQPMGRSPVPSAVITEADSTAMVGNKSDPKYLIRRVSSERVQTPGYRGSGIGFGQALFKRDKNPLSISKPMNPILGDYQPRPSIELGRATPVGEPIAAAVAKPARKASQRKTDEGWGKYFQSDPQTGNRTMFFGGRSSGASRGKSGFWPGSGVPETSTRSTTARSTKIVLRDSHGNPLQAHTVMAGSPTLAHGPPDPQSRGLEVAEGIPARISRASSVMTDSDEDYEDERIDGAFSSGIPASVSDMPWTPVGNTWGGPAQRPLRPPSSYYQTQDMPLQTASSEETTGTQSSSIPSFPMPNSVRSMNPDGGSITTAEAPLVRVNGRTQEARDYFTHARARSGTPENNDMSWLNLGTPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A2N3</accession>
    <name>A0A0D2A2N3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_03501</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239423.1">
        <property type="nucleotide sequence ID" value="XM_016377853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A2N3"/>
    <dbReference type="STRING" id="91928.A0A0D2A2N3"/>
    <dbReference type="GeneID" id="27330584"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03501"/>
    <dbReference type="HOGENOM" id="CLU_019988_3_0_1"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="277"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="164"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW19207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="517" mass="57728" checksum="CBBD6A1C58DF55D0" modified="2015-04-29" version="1">MVVLAASICTRGGKALLSRQFREIPKSRVEALLASFPKLADSSTQHTTVEQENVRFVYQPLDELYLVLITNKQSNILQDIDSLHLFGQVVTSICKKPDEREILRNAFELLSAFDELVTMGYRENLSLNQIKTFLEMESHEERIQEIIARNKELEASEERKRKAKQLELQRKEAARSASYGRGIAPKMPQQPTYTPPTQPNTYDTYEAEKNKVSSKFSASRATKGMQLGKKSKTSNAFAKVQEELGPEPETPLVEDLPDRTRPSTSTSTQDHTASAHTNPVVISISETLSAKLSREGALRSFEVKGDLQLKIADPALTKLALRVSADEGPLRAQFRTHPNVDKNLFNSSRTIQLKDTTKRFPSNNSIGVLRWRATAPADTPDVLPLTFTAWVNKSDDSYTITIEYELTNTDVTLRDVSVTIPYSSSEPSVSSFDAVYQVTGDSLEWTIGTLDADNASGSFEFEAQADDDGEFFPMTVSFEMTKPFVDVDVLAARLLEMDEDVDFEKVVKANADGFLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A413</accession>
    <name>A0A0D2A413_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">IQ domain-containing protein IQM6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_00165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239808.1">
        <property type="nucleotide sequence ID" value="XM_016374532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A413"/>
    <dbReference type="STRING" id="91928.A0A0D2A413"/>
    <dbReference type="GeneID" id="27327248"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00165"/>
    <dbReference type="HOGENOM" id="CLU_020021_2_0_1"/>
    <dbReference type="OrthoDB" id="7344096at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250:SF27">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
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        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW19592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="62020" checksum="7FFFF92E49E73275" modified="2015-04-29" version="1">MVDAPEDGESGAQPIIPGLSEKDSLKAAILIQKSYRGHRARRQLKGFGLDATTRWYEAVKVAKYQQLTIPRDSAQPYNVSGIHGKTSEEGEAPLSPTRKKWFKATEIARRAAADDQSPSVSDLSSDESDGAEEAKRKRQESNELRKKTAKMMDLQYFLEMVDQKHRYGSNLRKYHNYWKAQDTTQNFFYWLDQGDGRNVSLPECSRERLDKEQVRYLSREERLNYLVKVNSEGLLVWAKNGELVWTKDELYKDSINGIVPVNDSAPKWQHNVPPTNSEGPYSSSSDDSSDESSEDGDGHTAGDEGERYVNEGFHRAKGPAKLKHVSAAVLFNHMIRTSLKKGHKWIFVNTSLRLYIGYKQSGAFQHSSFLHGARILAAGLIKIKRGQLRRLSPLSGHYRPPANNFRTFVHSLRDMGVDMSHVSISRSYAILIGLESYTKTRKKIKLAERKVVHEKDKLINPAKVKAEEEAQQDKSMSAEMERLHLLEQQREAAEARANERKADRSISGRLSRAMSRLKPYKESEERSPRRLPGTGPEDGIPAPEGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A660</accession>
    <name>A0A0D2A660_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240498.1">
        <property type="nucleotide sequence ID" value="XM_016375222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A660"/>
    <dbReference type="STRING" id="91928.A0A0D2A660"/>
    <dbReference type="GeneID" id="27327940"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00857"/>
    <dbReference type="HOGENOM" id="CLU_011784_4_1_1"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="9">
        <location>
            <begin position="168"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="590"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW20282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="659" mass="74435" checksum="B000C7C61CA001B9" modified="2015-04-29" version="1">MKTTWKDIAPVPTSQEFIDIVLSRTQRRLPTQIRAGFKISRIRGFYTRKVKFTSETFCEKLQAILEGFPRLQDIHPFHKDLLNTLYDADHFRIALGTLSTAKRLIETVARDYVRLLKYAQSLFQCKSLKRAALGRMATICKRLKDPLVYLEQVRQHLGRLPSIDPNTRTLLICGYPNVGKSSFLKSVTRADVDVQPYAFTTKSLFVGHFDYKYLRFQAIDTPGILDHPLEEMNTIEMQSITAIAHLRSAILYFMDLSEQCGYSVQAQMALFTSIKPLFANKLVFIVVNKTDVTKPEDLDPELQRQLQDLLTQNSNTELLQLSCITNEGVQEVKNTVCDRLIADRVAAKLKAGQASQSATADAPSGRLGDLLARIHVARPMEGAVSETYIPEAVKNGTHKRYDKSDPERKRLERDLEEEEGGAGVYNIDLKKFYDLADPEWKHDKVPEFFNGKNVADYVDPDIEEKLAALEAEEERLTQEGFYDESDSMDDEEDAEIHMKAELIRNKRTLIMNEARMKKSLKNKAQIPRAKKSRTLGQMEKHLTSIGLDASSATDRARAQIRNAPARSTVGDEMEIDTPSARVKAISRAPKTNRLTDGLGASATGVTDPATREKASRMAKLSQRKMNRMARQGEADRHETASLPAHLLKGKRKMGSTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A767</accession>
    <name>A0A0D2A767_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8032 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240828.1">
        <property type="nucleotide sequence ID" value="XM_016375552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A767"/>
    <dbReference type="STRING" id="91928.A0A0D2A767"/>
    <dbReference type="GeneID" id="27328270"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01187"/>
    <dbReference type="HOGENOM" id="CLU_014950_0_0_1"/>
    <dbReference type="OrthoDB" id="5599902at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058345">
        <property type="entry name" value="DUF8032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26087">
        <property type="entry name" value="DUF8032"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="313"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="585"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="766" mass="84147" checksum="F44599423BCDB830" modified="2015-04-29" version="1">MQHRTPQSYQNIVAPPHVSQSRTLSSTVTSQQPYTSTNVYAQQANLHSPFLNSQHQFQAQAQNDAPNYFQPNQSPRSQSSVAGTYYPTEKPDSMAATATMQRPYPPIYTPQSNSPASVTSPQSHDHGRPMYPQPGPQLSQLPYGYPPYQSMNQVHQPPYGNHHGQTQQHQIQSQPMMSYQSTTPQLPQGPQHHSTISSSPRLKSENAQPYQQTPQARPGMLPHQQQPQHPSTNPATPGLGDYKQQGLGDYKQPGLGDYKQTLQQAQQQSGQQQQQQQHSPSGMQPNLPPGANAAPGPIPATTPLVVRQDGNGVQWIAFEYSRDRVKMEYTIRCDVESVDGSALTHEFKSENCVYPRACVPKDQYKGNRLAYETDCNQVGWALAELNPCLRGKRGLIQRAVDSWRNSNQDPRLRSRRVRRQAKINHKGKVTPSTPSQASGPVGSIPTGLPGPNSMPASGVRPPGVLPSAQNQILHNQQDVSPTAHSNVGASSYNTAPQGYRQDAASQHMSSPNDVRQSHVFPGYPSYPPAPTSMAPSMPPHMQGGLHHLGRPGGTAAMTSRDLEGKNEDDSALFGDLPESKRRKFILVEDTQKNARVRVKVTLDQIEMSEIPDSYRKQNSVFPRAYFPVQMQTADSTRGGRLAEEGEEVDGGAPTIGKTSVSVQTSNGEAEVSVPQISKSKRSREQKINELGYRMAWGQGRVFSGRPVFLARALDAYRTKQRNALLAAGSDASAIPAHLENRPGKRKWLERAHAVAHPLTPPTTTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7M1</accession>
    <name>A0A0D2A7M1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241003.1">
        <property type="nucleotide sequence ID" value="XM_016375727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A7M1"/>
    <dbReference type="STRING" id="91928.A0A0D2A7M1"/>
    <dbReference type="GeneID" id="27328448"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01365"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="263" mass="28094" checksum="CB59B4E980AE395E" modified="2015-04-29" version="1">MSTPTKTIALISGANTGIGEATARILAQDHGFHVLIGSRNLEAGQKVADSITSQGHSASAIQLDITSDASIAAAVRQIEQEHGGVLDVLINNAGILIDYLLHGRTEPSSSSDKDGKKEEDYPSTREIFTRTMLTNVVGTACLTDACVPLLRRSTHPRVIFVSSIMGSIKEATVKSNMWYPIDYKAYDTSKAGVNMLTVQYARILEDVGASVNAVCPGLVRSQLTRYSMGDPPEVGARRIVELAIAEKGGPTATFTNIHGPIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8P0</accession>
    <name>A0A0D2A8P0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_01722</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241358.1">
        <property type="nucleotide sequence ID" value="XM_016376082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8P0"/>
    <dbReference type="STRING" id="91928.A0A0D2A8P0"/>
    <dbReference type="GeneID" id="27328805"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01722"/>
    <dbReference type="HOGENOM" id="CLU_013513_4_0_1"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.20:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000025">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="9">
        <location>
            <begin position="85"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="611"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW21142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="843" mass="93395" checksum="C934EBBA0438D3E2" modified="2015-04-29" version="1">MPVSIAGTRYFSQPTSIGDTLSKTSLKAAANDMGAEHVERALEAAKEVKDSYTKQEKEPISAPTLPKDHLKQGITFAAQDKLPKLPIPDLDATMKKYLEALAPLQTSQEHNETRAAVRDFLENEGRDLQDRLKKYATGKTSYIEQFWYDSYLNYDNPVVLNLNPFFLLEDDPTPARNNQVTRAASLVISALCFVRAVRKEELPPDTLRGTPLDMYQYSRLFGTARVPTDSGCIIGQDSESKHVVVMCRGQFYWFDVLDDNHDIIMTEKDLAINLQVIVNDAEEIPIQEAARGALGVLSTENRKVWSGLRDLLTRDEGSNNADCLSIVDSALFVICLDYTEPADVSQLCGNMLCGTNEVVRGVQVGTCTNRWYDKLQIIVCKNGSAGINFEHTGVDGHTVLRFASDVYTDTILRYAKSINGQAPTLWTSQSPDPSKRDPESFGDVKTTPHKLEWDMTPELSIALRFAETRLADLINQNEFQTLDFSGYGKNFITSMGFSPDAFVQMAFQAAYYGLYGRVENTYEPAMTKMYFHGRTEAIRSVTPESVEFVKTFWADNTPQKKIDALKSACQKHTAITKESSKAQGQDRHLYALYCVWQRKMNDEGAEVASNAGFSSNGYSSPTDLSDAGSPKRLEDPPISPTRSQAGTESSRSPAPALHQMPALFSDAGWEKINNTILSTSNCGNPSLRHFGFGPVSGDGFGIGYIIKEDSISVCASSKHRQTRRFVDSLESYLNEIRRLLKATRPRAISAGKLTRAREAEEVGKDGRLKSRGRAIKAEATRVDGTQTPASMETAEVEDDGLGGYGFFDAGMLLQALKKEPPKPAEQLAQKKRTVGKKLALTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A9G3</accession>
    <name>A0A0D2A9G3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241623.1">
        <property type="nucleotide sequence ID" value="XM_016376347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A9G3"/>
    <dbReference type="STRING" id="91928.A0A0D2A9G3"/>
    <dbReference type="GeneID" id="27329070"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01987"/>
    <dbReference type="HOGENOM" id="CLU_074388_0_0_1"/>
    <dbReference type="OrthoDB" id="5374569at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="343" mass="37680" checksum="3C4DC20977909DB5" modified="2015-04-29" version="1">MARTLPWSTDQAPSTKRQRTIRSAGPHPEPPFSSPTRGRAGETLDTPPGNILPNATPSKQENDGTPASSPAKAPPSSELMHEGYDGDDIYIMVEDEFNTVAQSYTAHLHLAEYKRLVRQAREAPPKALPEPTSPMSKQAKQRLKADALQHRQKEALQKVLSRSAPDDEEEDTVDDPWSGTSLAPLMAGSNQRKTSLLGLEKISSNTKAGMGFARPTSSGSSGRDQESDDLSTKRNALGKPPTTWDYDMSTRLPSPTSGTAIENSSQYTVATTAKQRNARANVHPISHAPASVEVTTAEPAFSHSGTRRPRTMLRQHKDRLRTRQLEDEKKKKSRLEEVPMFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASJ3</accession>
    <name>A0A0D2ASJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_12070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847505">
        <property type="protein sequence ID" value="KIW09683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229899.1">
        <property type="nucleotide sequence ID" value="XM_016386377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASJ3"/>
    <dbReference type="STRING" id="91928.A0A0D2ASJ3"/>
    <dbReference type="GeneID" id="27339153"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12070"/>
    <dbReference type="HOGENOM" id="CLU_378129_0_0_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="2">
        <location>
            <begin position="6"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="3">
        <location>
            <begin position="562"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW09683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="733" mass="82298" checksum="2B76F0D2D594E097" modified="2015-04-29" version="1">MAEAAGLAFGILGAFNDAIQCFEYVQLARNFDQDFQTAILKLDIAKLRLSRWGQSVGLDQVVEGTQSLPGVSGSADDHEKAKELLDQIVGLFEDAERTSAKLKPLGSDTKVYDTNHDLDEATTSLHKRLEMLSLKRFKPGNILKKAKWALHKEKYFNRLIQDTTELVSGLIELFPAAQPKQKHLCEEDGSELASDQNASLIAPIVAEQDPELSAAIKSQHSAGAQNFNITFAGSHNYGLQQGYFSGQQTNNFGAQPSPPPRPPPPPSASIPFRRDRDCDFVERDVLNDLWQRASEPAARIGLVGLGGVGKTQLAIEYAYRVRNEYPDRWVFWVHANSAARFEESYKKIAERVQLAGWNEPKTDILGMVYTWLSNEDNGRWVMVIDNADSPDVMFEPRDCAGRTPGQPITALSSTSHSLSDYLPSSANGSIVITSRSREVTTGLVEYEEDILDVSPMAEAEAVTLLTRKLKRQDVNTISHGDLRRLVRRLDYIPLAITQAAGYINQRAPRMTVSKYLEILEGGDQERSKLLLTDIRDPRRDGQASNSVIATWHISFDHLWHSRHSAARLLSLMSLFDREGIPDYLLQDRYLDDQSEEADFEEDIATLTAYSLIGVGSTSNVFEMHRLVQFSTKTWLEVRNELTPWQERYVDILGAVFPTGDFANWPTCQILFPHVEATNGYQLTSKEHLLMWATIQHRGAWYELEVGRYGVAEKMVRSSFMAREAILGSVTLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASS9</accession>
    <name>A0A0D2ASS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_11883</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229999.1">
        <property type="nucleotide sequence ID" value="XM_016386191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASS9"/>
    <dbReference type="GeneID" id="27338966"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11883"/>
    <dbReference type="HOGENOM" id="CLU_022332_0_0_1"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="9">
        <location>
            <begin position="44"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW09783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="401" mass="43389" checksum="E9371879E46E465D" modified="2015-04-29" version="1">MADAEKKVRLSGEQPRAAEPATILPTVNPAAEKSAPPAPALHPAVYVVTWIGFSGGVILFNKWLLDTLGFKFPITLTAWHMIFATIMTQVLARTTTLLDGRKTVKMTGRVYLRAILPIGFFFSLSLICGNKAYLYLSVAFIQMLKACMPVAVLLTSWTMGVDSPSLKTLGNVSLIVVGVVIASYGEIAFNLTGFIYQAGGITFEATRLVLVQRLLSSAEYKMDPLVSLYYFAPVCAVMNGVTALLLEIPQMSMNNVYDVGIFMLIANAMVAFLLNVSVVFLIGKTSSLVLTLCGILKDILLVACSMMIWGTPVSGTQFFGYAIALGGLLYYRLGAEQLKGYVGHMGRSWSEFGVQRPALRKALVFGLVLITLFILLGGLAPTYAPDQTKNLKDMLSSGMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT14</accession>
    <name>A0A0D2AT14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_12109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847518">
        <property type="protein sequence ID" value="KIW09640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229856.1">
        <property type="nucleotide sequence ID" value="XM_016386416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT14"/>
    <dbReference type="GeneID" id="27339192"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12109"/>
    <dbReference type="HOGENOM" id="CLU_854049_0_0_1"/>
    <dbReference type="OrthoDB" id="5243188at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW09640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="326" mass="37100" checksum="6A667FDC5E379D87" modified="2015-04-29" version="1" fragment="single">MGSVLKPLNTIDSIEQGAWPYIDPRLLDLQTVGGDLNVALWPRGAKDRPVLMHVAALAYHYGPAVAASRQTHVWFQELGGKSMSAPTQFTRMLENVFEELLIPQQVTFFRYNIERLLRDEDHHREVQGSPERLLDNQFSLLERWSRSKYPFAWREFEPVMSTLIAPYSVASNPTSTKARLDFSRELYECCTSPDAAHKSRFASTHATWFAILRHVLQNFTAGHFKVEHWVAAISAAMLSCQIECVPGVYQSRLSFRRVIRLIGYTTPVGVLSAPVGSLKRLAMEAQHQAKRTRTTSHIDFGCSIPFTQIPELVKQGFEAQELHFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWR4</accession>
    <name>A0A0D2AWR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_10438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231354.1">
        <property type="nucleotide sequence ID" value="XM_016384752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AWR4"/>
    <dbReference type="STRING" id="91928.A0A0D2AWR4"/>
    <dbReference type="GeneID" id="27337521"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10438"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_1_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="155"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="330" mass="36358" checksum="4C26DCC0B02C5A11" modified="2015-04-29" version="1">MTDAIPVVSFERFLKGTRADQQEVAKQVYDAFSTVGFIYLKDTGISQARVDEIFELAETFFSLPLDQKLSYKLSSASTNQGYTADGAEGINDHKECYEHRRFANPLCPSSTALPGFKDTLDGFYSECLTLSLGVLKCLAMALGLGDDFFAPITAHADPQLRLIHYPPLHRDVIDAQGHARIMPHTDFGLCTLLFQDGTGGLEIDPAHDGEFVPAPPVAGTVLVNIADMLQRYTNGRVKSTRHRVVKPAAQDGFVGDILPARYSIPFFVHPDPETIIDPITLTEGEVKLYEPINAGEWRIWNTTKDYKLKDDSANGGRVFQEMGGVVEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXY0</accession>
    <name>A0A0D2AXY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231744.1">
        <property type="nucleotide sequence ID" value="XM_016385142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXY0"/>
    <dbReference type="STRING" id="91928.A0A0D2AXY0"/>
    <dbReference type="GeneID" id="27337912"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10829"/>
    <dbReference type="HOGENOM" id="CLU_079097_0_0_1"/>
    <dbReference type="OrthoDB" id="4117078at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="32728" checksum="256B0162A6915716" modified="2015-04-29" version="1">MNPVATAWVRACRGAPTRCIVLTYPSNITSFSVSRLHRRHAPQSQQAPFSSLRPAREAQRAHDNVSSVSEDPLISSSAAQSSPLSGATAGSIPLSSTTNTPFNSTTPVAYAAENPDDATKPAKGHTLVGRVSRVGTMNKTVRVSRTIQVWDRHLRKYYKRKAHDMVHDPFNILNEGDVVEYGSHAASIVQAPSSVRDEVHAAIGAVPESTGSGSEGEGKAPVNITYAPSGVSSLAAAGTTGGVTGTSIGVAAPTKNVKYVVHQVITPFGLPVHMRLPRTVGSPKGRWEGTAGEVLKGNVRQKARGKSKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZ00</accession>
    <name>A0A0D2AZ00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_10992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231906.1">
        <property type="nucleotide sequence ID" value="XM_016385304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZ00"/>
    <dbReference type="STRING" id="91928.A0A0D2AZ00"/>
    <dbReference type="GeneID" id="27338075"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10992"/>
    <dbReference type="HOGENOM" id="CLU_076902_3_0_1"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000043">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="45"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW11690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="134" mass="14369" checksum="EF5C56B810CF5972" modified="2015-04-29" version="1">MSERGHFRGGARGAGGGRGGRGGGGGRGGGSSQQTNQPHEKPKKENILDLTKYIDKEITVKFNGGREIIGTLKGYDQLMNLVLDDVKETMRDDEGNETTRSLGLIVARGTLLVMISPLDGSEEIENPFQLPAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0P1</accession>
    <name>A0A0D2B0P1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232491.1">
        <property type="nucleotide sequence ID" value="XM_016383868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0P1"/>
    <dbReference type="GeneID" id="27336635"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09552"/>
    <dbReference type="HOGENOM" id="CLU_031812_1_1_1"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="175"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="405" mass="44064" checksum="6507F62043818454" modified="2015-04-29" version="1">MGLQEQQKVADETITKASPELRDINWDLHSHPEVLFQEHHAHKVLTNFLEERGFKVDRSAFGLETAFRASYGPEGARAVAINLEYDALEQIGHACGHNLIATAGLAAAIGTAEAIKQGKINGRVVAIGTPAEEGGGGKIKMIRAGAYDDIFCCVMVHPAKKDNAYVTSMCGSELTIEYIGKPAHAMAAPWDGINALDAVTLLQTSIGLLRQQIMPSDRIRGVVLQAGQRSGVIPAYAKARYCVRSASLERYSVLKQKFINCLEAAALATGCELKTDWLPAYWDIRTNEALAAKFVEHMERQGVSFRSAYEQKMDQDCFSTDMGNVTYVVPSIHPTFEIISPGGTIHTAHFAAAARAQDAHDRTLRCGRAMASTALQVLMDDDFAAAVRRQFDAEDWSIAADPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B165</accession>
    <name>A0A0D2B165_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232631.1">
        <property type="nucleotide sequence ID" value="XM_016384008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B165"/>
    <dbReference type="STRING" id="91928.A0A0D2B165"/>
    <dbReference type="GeneID" id="27336775"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09692"/>
    <dbReference type="HOGENOM" id="CLU_007383_6_8_1"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="467" mass="51558" checksum="B1397C83741B5717" modified="2015-04-29" version="1">MAEIETGALHNGAGAEHPATGKDSREPCFRVLVTGGLGFVGSAIVRALQQHHPEWIVCILDVENGPGESLQDEYDELDLLRSCSYEYVQADITDFNVVMRVFDRVRPDAVVHTAGIVPPLRERYSRRMESVVKRVNVMGTRHVVEAARSVECRAFVYTSSCCAVVDDMTKPYPNIDERWPTPKKSSIYGESKIEAEKIVLAANRSHISPEKVVVCDGESSSAMLTCVLRPSVIFGEGDHQLTPSLHACIAKGESRFIVGDGCNLWDATYVGNVADAHVLALANLLGVGSRREEPQADMNEQLPEIGGNGVPSAAGETFFIQNNEPISFRDFSLAVWKEFGHYPPWLEIRIPEGLGWILGLVAEVFTRISGTPTTLSRGSVMDAVAMRYASGDKASRILGYHPRTGLEVGIRKSCRVSNVTCLHSHLLVFCKAATRIWPQEQVLTKCNVIQDYARRLEKGRRLRAHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1E8</accession>
    <name>A0A0D2B1E8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232686.1">
        <property type="nucleotide sequence ID" value="XM_016384063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1E8"/>
    <dbReference type="STRING" id="91928.A0A0D2B1E8"/>
    <dbReference type="GeneID" id="27336830"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09747"/>
    <dbReference type="HOGENOM" id="CLU_002341_6_1_1"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="296"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="4">
        <location>
            <begin position="574"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="993" mass="113188" checksum="E0CF2BFFEB554413" modified="2015-04-29" version="1">MVIPPLDALSIAAAVVQFVDFSCRIISKGNEYHKSIDGSLVENKELEVVAANIQDLSGRLHSTLSSKAKRALRKNLNGRTAQEQDQPLSYEEQALQAVVVDCQGFAAELLDALERLKLRGNSTRWKSFRQAFKTIWEKEKIEAMLTKLSQARQQLVVNLLVVLSTHSESEFNQIKESNARLEATLLATIKDSGASIQREIAKLSLVPSCNSIQQKETFKSTWSARNETDLSRMALALTAATRLDRANSNNTMLLDSLYFTQIAERKSNIRQAHTSTFKWVFEPRAEFEDRWTNLPRWLDGTEPGQNVYWITGKAGSGKSTLMRYLYEATETKDLLNAWAGNSKLLTACCFFWNPGNEIQKSLNGLLRTLLHELLTHSPNCIKTVAPWRWRSLDLGAKFLEPWTDAELLNVLDAFFRDTAKDTRICLFVDGLDEFHGTDETRENLIELLQSLASNDNAKICLSSRPWNIFEDAFGRGPMLRLEDLTRPDIRQYVSEKLTQHRRFEVLKQLYEEECISLVDNIVDKASGVFLWVYLVVRSLTQGLRDEDGISDLTRRLELIPADLELYFDQMLSTIDPFHLPRSSELFQLTMCTDRRLSQLTLSFIHEDKPDALVTFLRKDREAAILHAYNSTSRRVNALSKGLLEVNRTDSTNPYFMYGVDFLHRTVRDFLAMDEVRQKLEKYSKGAFPCQLRLCTAVLAQIRSLGPNFESLTDAEAFLRLLDEFLFYASALEMTRSRIPEELFAALRERLDLFDISNVVNIAGLRSREVQALDLRNNLKMFTSAHWSEGDAGDKNNQLSFFISTGLFDPVADLIGSHPDAISKKEGRPLLDYALRRDRHAAIELKLPNLQTTRFLLESGADPNQMYNERTVWHGFLSWMRDNQKIISPSQKAWADATKLMIEYGADAFPTVGAFFREIFDTQTAKELNTLLSERVAESEAETETKEGDSELSTAGIWLPRSRLEKKMKLMPAEKGDQGILAGFRQMFTWSQWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1W9</accession>
    <name>A0A0D2B1W9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">PV08_09873</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232811.1">
        <property type="nucleotide sequence ID" value="XM_016384188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1W9"/>
    <dbReference type="STRING" id="91928.A0A0D2B1W9"/>
    <dbReference type="GeneID" id="27336956"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09873"/>
    <dbReference type="HOGENOM" id="CLU_003376_0_0_1"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="742"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="774"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="816"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="869"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="893"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="27">
        <location>
            <begin position="115"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="26">
        <location>
            <begin position="260"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KIW12595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1123" mass="118224" checksum="7EC84F7CE6CC6955" modified="2015-04-29" version="1">MAHSVFSSCSLQLPAKLSTKGCFMRLDQGMKRSFIHRDVLSAKTVSAFRPSILHLRTRQNQHAKRHVYSRARGIVPPSVQSGSLTRSPPKPVVVWTRSKSEVPTSSVPYTKLTLGVPKETHPGERRVAVAPQNIPLLLKKGFSKILVESGAGTESEYPDELYEHMGAQVVDRKTVWTESNVLLKVRPPDVENEVPNIRQGAALISFIQPAQNKKLVDALAERHVTTFAMDMIPRISRAQAFDALSSMANIAGYKAVLEASNHFGRFLTGQVTAAGKIPPSKVLVIGAGVAGLSAITTARRLGAIVRGFDTRSAAREQVQSLGADFLEVTVKEEGAAAGGYSKEMSKEFIEAEMKLFMEQCRDVDIVVTTAQIPGKASPKLITEKMVSAMKPGSVIVDLASEGGGNCEVTQPGKLIVHNHVTVIGYTDFPSRLPTQSSSLYSNNITKFLLSLAPQENAFGIDMDDEVTRGAIVTHNGQVIPPAPRPAPPPTPTQHSEESETKPVELTPWQRQTRQVATVTGGMSAALALGKLTSPLFMGSMFTAGLAGLIGYRSVWGVIPALHSPLMSVTNAISGIVGVGGFFIMGGGYLPETVPQALGALSVLLAFVNVSGGFVITKRMLDMFKRPTDPPEYPWLYAIPGVLFGGGFIAAASTGMAGLVQAGYLVSSLLCIGSISGLASQATARTGNLLGILGVLSGILASLAAVGFSPEVMAQFGGIVAVGALVGALIGRRITPTELPQTVAALHSVVGLAAVLTSIGSVLAHVSDISTLHMVTAYLGVLIGGITFTGSIVAFLKLAGRMSSRPTILPGRHLINSGLLAANAGTMGAFVTMAPGAPTVAAMCLSANTILSFAKGYTTTAAIGGADMPVVITVLNAYSGFALVAEGFMLDNPLLLTVGSLIGVSGSILSYIMCVAMNRSLTNVLFGGIAPIVQTPGQEIKGQVTKTTVEETVESMANAESVIIVVGYGMAVAKAQYAIAEITALLRSKGVSVRFAIHPVAGRMPGQCNVLLAEASVPYDIVLEMDEINDDFPDTDLTLVIGANDTVNPIALEPGSPIAGMPVLHAWKSKNVIVMKRGMSSGYADVPNPMFYMPGTKMLFGDAKSTCDALKAALETRYKAQFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4B5</accession>
    <name>A0A0D2B4B5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234019.1">
        <property type="nucleotide sequence ID" value="XM_016383316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4B5"/>
    <dbReference type="STRING" id="91928.A0A0D2B4B5"/>
    <dbReference type="GeneID" id="27336078"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08995"/>
    <dbReference type="HOGENOM" id="CLU_000288_31_3_1"/>
    <dbReference type="OrthoDB" id="5338352at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="276" mass="31616" checksum="AB379CE0728E7DEE" modified="2015-04-29" version="1">MASQSEILLPRDLSSLPFINAGVTSVVRALDEHSVIKLTGDEDSLRALEVERRILERLGEHPRIVRLLYVHEKKLVLERLLYPLLVRLLELRDEEAAPSTEEILKWSAQAAEGMEYFHGKNVLQIDIGSHNLLLDWDENIKYCDFSGSCIDGGWTYAAPSTRAQHPSISPKSPSVQSEIFALGSVLYEISTARKVYEDLEEWEIERHFTQGEYPETQHLLLGHVITKCWSGGYNNAGQVAAEIRAIQRRFKYGDLNLPLGHYMRKQKESRRLRRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4V3</accession>
    <name>A0A0D2B4V3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233951.1">
        <property type="nucleotide sequence ID" value="XM_016383248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4V3"/>
    <dbReference type="GeneID" id="27336009"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08926"/>
    <dbReference type="HOGENOM" id="CLU_612491_0_0_1"/>
    <dbReference type="OrthoDB" id="3946700at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="436" mass="48438" checksum="80BD60ACECF6A986" modified="2015-04-29" version="1">MFREPEEDAADQATTKLDRNAATRRSSIRRESTLRPGRNTTSRQLLQLLRAGEVQVVQEPEHSRPSGLPSRIPERDIHDLDFELDRLRSMRQRRRARATQLERELASRSNIDPIRPEADLRRDIDLDALAEAGMEVFLSDSEGNLTQHLPRPSRESGLRFEVAATPSSESEQSRRARIDSDNLRIPFQPPVASTPAWAYGPAASDTDDDNDNENPSSTSIFPPRSPFRPPPPVAGTRRPIGGVDGLLDTPPPEGLEASYPPLRRVNHMSPRPLGMSSSRMDGLGDRVRSPSPSSPQEENWSSLLSNIGTGRSSVATSFMSRSDSRNGSNRSSQTAATSFGEIGGDDSCDLDLPSGITEEDARQIRARHGRLGRRTIGVRRHGPTSEELERLSRGNDRLLELELFGVILDRMQRREEIPDDWWAAVGLSSEVVRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B703</accession>
    <name>A0A0D2B703_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234924.1">
        <property type="nucleotide sequence ID" value="XM_016381822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B703"/>
    <dbReference type="STRING" id="91928.A0A0D2B703"/>
    <dbReference type="GeneID" id="27334575"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07492"/>
    <dbReference type="HOGENOM" id="CLU_026673_14_1_1"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="16"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="384" mass="40809" checksum="4412100DDF234B90" modified="2015-04-29" version="1">MALLGHGDNNEQSILGSTEALVVSQLGGPFELKELQLKEMRSDEIVVKMVATGICHTDLATAHGFKGPGLPAVLGHEGSGIVEKVGADVKHVGVGDHVLLTYNACLECTPCRRGKYSYCKHAERLNFGGSRLDGTRTFSYNDEDINSAYFGQSSFAKRAIVRGVCAVKVDKTLPLDILCCIGCGIQTGAGTVLNVLKPHVGSSIAVFGVGGVGLAAVMAAKNFTPATKIIAVDIVDSRLEMARDLGATHVLNSKGRDIVELIHSVTDGDGVDYALDGTGKLAVVQAMIASTANSGIAATVGGVPAGQHVQIEPSTWLQRNVSYIGSCQGSSVPQQFIPALAEFWRQGRFPIDRLTRSYPYKEVNQAIDDMHHGRTIKPILIWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BA26</accession>
    <name>A0A0D2BA26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236064.1">
        <property type="nucleotide sequence ID" value="XM_016380237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BA26"/>
    <dbReference type="STRING" id="91928.A0A0D2BA26"/>
    <dbReference type="GeneID" id="27332981"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05898"/>
    <dbReference type="HOGENOM" id="CLU_017860_0_0_1"/>
    <dbReference type="OrthoDB" id="4135937at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="178"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="557"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="723" mass="81559" checksum="6F774B6157FF10B1" modified="2015-04-29" version="1">MAPPRHLPEEIQAAVLRIKDVEVNNNTPKILNHAVVEAFSEEYLKGLKPGTFLLGTPDEEDELARSSTSRGDDSVGFDSLPSFGTQDRRSDDNEEDLLSDSMSLDEDLYQDEDEIPMGIEPDRKILVDGETYHVAEYLGKSWVAEIMAQHNVKPLQKPPNILFNPFDHQLKGAAQIDHCLEGVFKFFLLGDRMGMGKTLTATLAMWIRKDEPGMSLVVAPASVCAQWVNDIHRYFDEEGGLRAYWLHDPRKSASWLLSQGFDIIVVSYEFLETSLRPIQAFKGSIEAYANATRHATKKVHYPKRPTSALFSKIWKVTQQPWKRTVLDEAHCVSKRSGKRHQAILKLPTVGVVCLSGTAAHNKWTAFSGYLDFVKAHPWTSHARFMRTFCGANANPSNPGVVETRLLQRMLQAILVARPLDAEGMSRLHGLTAFAVCFELDPFDQILVATYTQKYKEEVVKTARMGDDQTDQLKNDGDDSRSAMGWASKARCAAAHPLLLAEIPKKANVQVPETSEQGPTFGRLKTITEDILDTERDYWLGLVQKDSRLMENSARVRVCVATYLWYRAQYPGEKIAIASVSLKILDIMDEVLKKRLQIDAVRFDGTVAPQKRHATLRKMEVAAPEVPLLITAGAGAFGINLPFISCLIQMEPWWNINMELQYTFRAYRLGQQKQVKYIRLEATNSAIDQETIEVQLRKKAVNDRVMAPLTHSHKDEPKILDLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBP9</accession>
    <name>A0A0D2BBP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_06051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236216.1">
        <property type="nucleotide sequence ID" value="XM_016380389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBP9"/>
    <dbReference type="GeneID" id="27333134"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06051"/>
    <dbReference type="HOGENOM" id="CLU_1304873_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="211" mass="24264" checksum="9540BDF4F9C28253" modified="2015-04-29" version="1">MATSGIATPESLLGHDLGLCCEPPTVLSEMRKLKVTLRGWPREMDEDDTWEDCRMLHLLCEILTDFLDLSQVSLTVALRYAKPFTWNTYERPESVLGALSLLRNLKSAKVCGIDRSYAAQLEALMMKSGRIENIWKMRRALQEWCEWWTGDRETDLDGDVPDAVYDSDIERFKLLRSDIIRGQQAENHPSVRDVFQYDLDPTQEHEALRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDM3</accession>
    <name>A0A0D2BDM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237234.1">
        <property type="nucleotide sequence ID" value="XM_016378557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDM3"/>
    <dbReference type="STRING" id="91928.A0A0D2BDM3"/>
    <dbReference type="GeneID" id="27331292"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04209"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36192" checksum="24A274F5879CB1BE" modified="2015-04-29" version="1">MPGNFLNPVHDDYKYDPDKHIPDLSSKVIIVTGGNNGIGKAAVTELAKHNPKRLYMTARSKTKYDTAMEDILAAVPTAKVDFLELDLASFASIKRAADEVIADNDQLDILINNAGVMGLPPHPTTKEGYEIHIGTNHVGHALLTKLLMPLLLSTASSSSSSSSSSPNTPDVRVVTLSSGAHNMASSGVPISRIATPMEGTWSFSRYGQSKMANVLFARELARRYPQITSVSADPGRVQTPLLDEKFKTRDFTTYFQKTYDLFASVLDPRQGAFTELWCATFDKAKVKSGEHYVPFGHRVPGHKKSRDEKHARELWEWQEAEFKKHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEB2</accession>
    <name>A0A0D2BEB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_12018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847503">
        <property type="protein sequence ID" value="KIW09734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229950.1">
        <property type="nucleotide sequence ID" value="XM_016386325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEB2"/>
    <dbReference type="GeneID" id="27339101"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12018"/>
    <dbReference type="HOGENOM" id="CLU_2654512_0_0_1"/>
    <dbReference type="OrthoDB" id="4159106at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW09734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="76" mass="9423" checksum="D69A06BB3EFA8374" modified="2015-04-29" version="1">MEIRALEEYNRHLKAEMRKYYQLQSVSQKLLEEVRTSTKRLKDAVLEFRRAHKDIEENFRQEEDLHEAEFLRSHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEE8</accession>
    <name>A0A0D2BEE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_04151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237176.1">
        <property type="nucleotide sequence ID" value="XM_016378499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEE8"/>
    <dbReference type="STRING" id="91928.A0A0D2BEE8"/>
    <dbReference type="GeneID" id="27331234"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04151"/>
    <dbReference type="HOGENOM" id="CLU_038704_1_0_1"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW16960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="399" mass="43155" checksum="07A6B4CEE1B29410" modified="2015-04-29" version="1">MSFSFGFAGDDIEDDDADQQDQVSLTGKISSCTINDKDALQPQTLAPKRHSFEDLLSSLPSQISYNTLTVPNSPPTTESPSTQSGTIAIHRRSLFDIRAQLMAEANPETHDAADILLSGLENGDLSSGIYEGGFKTWECSLDLASSSLVTSLDLSQNWHIVELGAGSAVPSLSFLTVFLTGNDDHQGPPPPSRGTLKFTLCDYNEDVLRLCTAPNVFLNYRRHLQSVQRRLRTQEATPSSRDQRADAEDVCENEGGDGDGDGDLDIEALGETFITTTLDDLKSLNVSFDFISGGWGDAFLDLIPNSGTDASSENLLILASETIYSPATIKPFTETVVKLLRRYPAANAKAWVAAKKVYFGVGGGVDEFLSEAAKHHVKSTRILETKDTGVGRVVLEVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFW6</accession>
    <name>A0A0D2BFW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238109.1">
        <property type="nucleotide sequence ID" value="XM_016379432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFW6"/>
    <dbReference type="STRING" id="91928.A0A0D2BFW6"/>
    <dbReference type="GeneID" id="27332171"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05088"/>
    <dbReference type="HOGENOM" id="CLU_545159_0_0_1"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="312"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="398"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="56211" checksum="183A607AC7AD47CC" modified="2015-04-29" version="1">MSEPPSSMSRSRSTTSLYESSGYGDESEGSSSVDESFSLENTSFVEPFVEKALSIYSKGSSSMTYTRTERQCILLLALVALHVVGGRNRRARSAMATPSRVAPRGAVTKPTTRTQNKLSISNPAAAARLLQKQQEQEKQEEEEQQQYEEERARQLQAQSREQSQYARDRTRRWVESLARHGPESQATLHHSKPDSSQPAAAAAAAAAATTLRRSPRANNSRKQEQEPQQETGVKRMQQESRVKKPQQETHVKQPQDTEKRLKRFRSKPPMSFQIKLERAKSQRMIVLGRKRIVKDDAPCELLEIVGSTGNVYEVVIGRMPSCNCPDALKGNECKHKVYAMHTVLKAPEHLQYQMALLISELEEIFASAPPIPSEVAASDLEKDSQQPGNNRKSTDGECPICYMDLDPKNNKLVWCKAQCGHNLHQSCFDQWVASMAGREVRCVYCRATWEVDVGDAEAIKKAGRHGEDGYINVAEQVGMSGHRDYSSYHRPWVRRQFGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGK6</accession>
    <name>A0A0D2BGK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238339.1">
        <property type="nucleotide sequence ID" value="XM_016376769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGK6"/>
    <dbReference type="STRING" id="91928.A0A0D2BGK6"/>
    <dbReference type="GeneID" id="27329494"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02411"/>
    <dbReference type="HOGENOM" id="CLU_047725_3_0_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33557" checksum="112F3189A2FB3DF5" modified="2015-04-29" version="1">MSLDTFNFYSRATARKPLPEDAGTRADIEHVLKHGYVVLPDCFTEAEAREARGEIVRLLGKDPLHGRNSFEGLNTNRIYSLLNKSRVFDKFLVLPRVLALNDYFLDPGYLLSAFHTISINPGEKAQALHHDDGYIQVPRPRLPFGAAIMVAFDEYTASNGATRIIPGSHLWDSSRRGTPEETIPALCPEGGVVYFISTLWHGGGANVSDRPRQSATVQYCNPYIRPIENQILAVDPRKLDQIDPRIVEMMGYKHMEPFMGYADGLGPRRAARRMVRWLQREVDDNPPTFAHEAPEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGL4</accession>
    <name>A0A0D2BGL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_11428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230680.1">
        <property type="nucleotide sequence ID" value="XM_016385736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGL4"/>
    <dbReference type="STRING" id="91928.A0A0D2BGL4"/>
    <dbReference type="GeneID" id="27338511"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11428"/>
    <dbReference type="HOGENOM" id="CLU_084253_4_1_1"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW10464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="175" mass="19635" checksum="4ABD173A08E07D51" modified="2015-04-29" version="1">MVLTSQELLQRHEASLVNFEPLPLLSELEPAQMPRMLIITCADPRCIPENIFNLHTGEAVVYRVPGGNAQFLLEHVLSLDSLLHFTECIIVQHTDCGATHFRDDKVKEGLRERAPDLEQQIEGLKFGEITGSLDENVKKSIDFLRASALVPEELKANTRGFVFDLKTGNLKEVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHI1</accession>
    <name>A0A0D2BHI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238634.1">
        <property type="nucleotide sequence ID" value="XM_016377064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHI1"/>
    <dbReference type="STRING" id="91928.A0A0D2BHI1"/>
    <dbReference type="GeneID" id="27329789"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02706"/>
    <dbReference type="HOGENOM" id="CLU_010001_0_0_1"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="779" mass="86476" checksum="D417F0E46A6C5B6E" modified="2015-04-29" version="1">MAPACEACRNLKMRCSRSALAEEPVNTSEPCDRCKHHGRPCKIPPSRPGGRKPGSRGRYKGVEKALRKIQTELRKAKHPSSSDQDNLRELLGFADGDQELIDLILSQNRSISDIQSQSDGYLETTSPSRSPNDTIQSPPEQNGSVSNPLGLVADVCGNLNLDPPSPSNMPLVEAESRPSFLATSAGESEPQNFARHLLRRPGYVSLGLKLNRQTLEDGLDALLTREVGICRYSDYFKPSDMTKDRDIGPDLDPVELGLASMEEAHYLFPLFFARLHPINGILDPILHTPEFVQSRSALLFTWIMAISAQFDHASGSIAKRLRIHGEHLSKHVYASGYKSVEIVQGYYISLLSAVPANTMVEERSWLYTIYAFGVAAELGLDREARAPGCSSDIAGSHTLPQASPGPDGSSDDRENNSQIGDPSFVKDPTDTERLARNRERTWLRILLWERAHSAARGRVSAFPETDLTLNIETWYCHPLADLNDKYTCAFILLRRHLGGLQDQLKRQIGFQHPSRHWVLDLIDSTLQPWCRSWLGSTEPLVTPSERVSNAFLRFVYMHGRLWTLSFALHGHAEDSNPNIDAIKEDCFESAVNCCEMAVHALQEIGEPIYCMLAPTWAMMAYSAVLALRLFPLLYGKQSGNEVELLSLLSQVALQLEKAGTTPSHRFGIAALLGQHLFKILRARANFLVRGAQSTIQSQAGSAALAGTTNLHLEHLVSGSIEDDSNQMVNQSQQLDFDPFISRFDPFLTLPFHHVNEDGFGEGFTDVLWDWVGQGFGNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BI35</accession>
    <name>A0A0D2BI35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238834.1">
        <property type="nucleotide sequence ID" value="XM_016377264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BI35"/>
    <dbReference type="STRING" id="91928.A0A0D2BI35"/>
    <dbReference type="GeneID" id="27329990"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02907"/>
    <dbReference type="HOGENOM" id="CLU_021928_3_0_1"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="212"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="630" mass="68610" checksum="EA57513FD31572BE" modified="2015-04-29" version="1">MRRAAVFALRTARRSAFRKFVPKSILSAPGNAAPVSASSNAVIRRYSTSRQPLQASMRLPKIPIAFVGTLGAISAWYAYRGDGPEQLLRNPTAPLSAQSMRSLSTKPDITSPTSEPTSLASVTAGQEPNRKALVVDNDQFFTGAIVGEGPLAKDTDDYGRKVLEMMTPEQATEKLRKNEQSYLVGRGRGVVRYDVVQLPSNDPIEDDHSEKIVEVPSSVAATDGAASSDWMFWGVFDGHSGWTTSAKLRQVLISFAARELNSTYKAALADAKSPFPPPAAIDQALKSAFVKLDNEICLDSVSKLSKNPSKRLAAEILAPALSGSCALLSFYDSRSKTLRVACTGDSRAVLGRRNTQTGKWFATPLSEDQTGSNPNEEARMRAEHPGEEHVIRAGRVLGNLEPTRAFGDAFYKWSRDTQDRVKRHFFGRTPHPLLKTPPYVTAEPVVTSTSIEPSKGDFVVMATDGLWEMLTNEEVVGLVGQWIEQQNKQASKSSNNTAWLTSWFKSSSPGALPVEKGGNMDKTGRIDNGKAGSGEKPIRQQQWDVKSENNGRFVVEDKNAATHLVRNALGGKDRDMVCALLTLPSPYSRRYRDDLTVEVIFFGEGEDTGAVVVNSEATAKNDGEGLKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ57</accession>
    <name>A0A0D2BJ57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinamide-nucleotide adenylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238826.1">
        <property type="nucleotide sequence ID" value="XM_016377256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ57"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ57"/>
    <dbReference type="GeneID" id="27329982"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02899"/>
    <dbReference type="HOGENOM" id="CLU_032651_0_0_1"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36756" checksum="820D47A97B1A6F31" modified="2015-04-29" version="1">MSDSDLDMNALQSLRSQFAQALTDFASSPSSTFKVLRSVQSTSPPSSSPIRTLYVLDSSFNPPSKAHLALVKNALRTTTFLSSSSRSETASRPPPPPQPSPPSQANPAESRVLFLLATVNADKTPEPAAFPDRLVMMTLMAEELRSALSDPPVVDIGITKKPYFVDKAASIDDSGAYATASPRDPGDHFEQIHLTGFDTLIRIFTAKYYPDHTPPLSALAPFLTRHRVRATVRVDKDSPSKNVKDTTGADEDLSSIDGQLAYLKRIADGDMESDGLKREWASRVDLVVDETGETQGVSSTRIRNAAKEGRWSDVNALVGRGVGDWIREDGLYTTTTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJJ4</accession>
    <name>A0A0D2BJJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239284.1">
        <property type="nucleotide sequence ID" value="XM_016377714.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BJJ4"/>
    <dbReference type="GeneID" id="27330441"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03358"/>
    <dbReference type="HOGENOM" id="CLU_261365_0_0_1"/>
    <dbReference type="OrthoDB" id="4152175at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF13">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1302" mass="146308" checksum="3E25B0105FB2619F" modified="2015-04-29" version="1">MRLLKVDGHGELTRCYPEENAPAYAILSHTWGTDADEVSFQDLGDGSYLKKAGWSKIQFCRKQAEKDGLLYFWVDTCCIDKTSSAEITVAVNFMFRWYRNAVKCYVYLSDVSASEEDKDHANVAWETQFRRSRWFTRGWTLPELLAPASVEFFSREGTLLGNKRTLEGLIHEITTIPIHALRGTSLKDFPVNERLRWASGRQTKREEDEAYCLLGILGASMPLLYGEGHSRAFDRLRETIDIFPRRWRVTRENHRGPNPDQLNVQAVQHIPANDSRKDTQNEPSFTDSGYGSLPNLHYATDARVPPHDLNNSLSSDTIDDESRQDTETHYSAATSVAPAEVHNYAIELCNDIFRKIGPDLDVHQWSSLSKALPRLIKAFAIMIGFESSAPVNREIMYFIHSQNKNIATYLDTIFQGEDNGESGSDRKTTDMSLDDKMRMWESKAGTDHTDPANHDDLYTGVEELEDEPPVLTDLSLYNSIIRDSYAYKWFLTSLQTESVLQCSETQPCIMIDDIRRKIMDEFPTGRISGRRGPHAYEGQFHLRWSGKTEQRFLRKTHKQPTGSQKSYADLITITGSIEEAQLLTIREYLGQTWPGRGCRLLDVIQEAVASHDRHCSVVFADKTRLEAIIVRSYLIVTAIGPAYFVAECGEQLSWLGAALQCYNDRRLVSTCAPSLRKNQQPYQLAPFSTKTTSQVSYEILFPVSSPMSSEDSVLDKQTRWQELVGNSVLITGFPVSRRPNGYPGLEVSFETLLSLLGADEASHNHGFIMVNGRKTTLCLIKCTGNIHLWHPFHNSLNLYPSCGNGPAETYSGNFDLRRLETGRHILIICMGFQAAMVADLDYEGMPTTDYKRMLSIHETNNARFQTQITVASPPIERDSSQSLRLSQQDKVRSLGHELCSHETGSGSSNFGTMVPSTLRHPRPRFGKVQTEEQVSPSVQKYLSAVGIEPDAMAGSPDYSLDSDLISLSGSSEDPELLDLDEGANESLNIVLHRLLSGFRSSIRDCAGSEIQGVSTGSAGSTSVDGSSEAQNDSGRSQKRTRQRRADDEDPDDPEKEGPPMPPPKTLKVSNEKTRQKSLACPYLKLDPIRYRKCCVDKHSRIRDVKQHLSRRHTPLRYCQRCFDTQFEDEESLKSHVDTGTCQRQDPSVLDGLSYHQSRQLSRKSKASLNEQEQWFAIWELLFPGRLPPSSAYLNTDLSLEMCEFREYCLHLGPAFVREQIQSEQSSLPLGLNTEQQHVALERLIGHGIIALFEDWHWRVSQSASGLPGGSGLQSMPHNTSTSSIADSGVALDSQPSPRGSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJM7</accession>
    <name>A0A0D2BJM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Parasitic phase-specific protein PSP-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_03089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239016.1">
        <property type="nucleotide sequence ID" value="XM_016377446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJM7"/>
    <dbReference type="STRING" id="91928.A0A0D2BJM7"/>
    <dbReference type="GeneID" id="27330172"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03089"/>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32870" checksum="8E947E9E58955CA8" modified="2015-04-29" version="1">MSSNEPVFVFNGTTYLGGGSNANCTISVCPVELSIYGYRPSLPLSISLIALYGVCGFVQIALGWRYKTWGYMSAMLLGCIDEILGYVGRILMYKNPWNHGGFIMQIVLITIGPVFFSAAIYVMLSQIVTYISPKHSRFDPRLFYYIFIPCDIVSLILQAIGGAMSSTSDGSSSAGVNIALAGLAFQVATLVAFVAMTVDYFVRSREVWRSAHLPLKFKVFVSFLALATLLILIRCCYRVYELNEGYTRHSGALRDQTLFIALEAAMVIAAAYALVIGHPGQVFYSGPRRLAGTGDDTTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK50</accession>
    <name>A0A0D2BK50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239514.1">
        <property type="nucleotide sequence ID" value="XM_016377944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK50"/>
    <dbReference type="STRING" id="91928.A0A0D2BK50"/>
    <dbReference type="GeneID" id="27330675"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03592"/>
    <dbReference type="HOGENOM" id="CLU_043688_0_0_1"/>
    <dbReference type="OrthoDB" id="2305845at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="381" mass="43064" checksum="2C407E7A0A3A93AB" modified="2015-04-29" version="1">MPSPLTVEGLQASDIHAKIESLMTNLVSIKDETGRFLQRLPDGRTIDTKGWNDWEWTHGIGLYGLYQYHTLTSSATALDVITRWFSARLAEGTTKNINTMAVFLTLAHLYEKTGDQSHLAWLDSWCEWAMHELPRTTFGAMQHITYVDENHNQLWADTLMMTVLPLAKVGVLLNRPDYVEEAKRQVLLHVQYLFDPTTGLFFHGWQFHDEGDAAAGRGGHNFARARWARGNSWLTIAIPDFIEILDLQPSDGLRMYLVSVLEAQCRALRALQTPDGMWRTLLDVAEDDGSYPEASATAGFAYGLLKAVRKRYVPKEYRDVALRAVKAVLRRINDAGELGDVSFGTAMGHDLKHYVNIERTSMPYGQAMAIMALVEFLRVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKU6</accession>
    <name>A0A0D2BKU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239441.1">
        <property type="nucleotide sequence ID" value="XM_016377871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKU6"/>
    <dbReference type="STRING" id="91928.A0A0D2BKU6"/>
    <dbReference type="GeneID" id="27330602"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03519"/>
    <dbReference type="HOGENOM" id="CLU_043293_0_0_1"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="187"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="434" mass="49302" checksum="419868E4958ED7D4" modified="2015-04-29" version="1">MANATLPDLPPLPSYTLTPRPSMIPGVPDIVCQLLAPVIAYWVVSGFFHILDVFDLCAKYRLHTPAEVLKRNHVTRWEVFRDVVLQQIIQTAFGLAVAYFDPEETVGREEYDVTLWAYRLRHVQQYVPGLLALIGLDAQALGSKLYAYPQLAAILRGGMYEPHTFASWEVLTAKFIYWIGIPAVQFTVAVLIVDTWQYFLHRAMHMNKFLYTTLHSRHHRLYVPYAYGALYNHPIEGFMLDTLGTGVAYLVTGMTIRQGMWFFTCSTIKTVDDHCGYAFPWDPLQHVTSNNAAYHDVHHQSWGIKTNFSQPFFTFWDRLLNTAWTGGDVSARYQRDRIAAQKKVDAELASKASVVNSPAIDMENAKQQARSSQKQVLENQDGARVIAEEAREEQEVKQSLRRSTRRKSGFDAKAFSDRMAGTLHGRSAAILHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLZ4</accession>
    <name>A0A0D2BLZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_00173</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239816.1">
        <property type="nucleotide sequence ID" value="XM_016374540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLZ4"/>
    <dbReference type="STRING" id="91928.A0A0D2BLZ4"/>
    <dbReference type="GeneID" id="27327256"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00173"/>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF3">
        <property type="entry name" value="TRANSAMINATED AMINO ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="9"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="207"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="406"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW19600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="578" mass="63966" checksum="1005F707366E3EEA" modified="2015-04-29" version="1">MSASTVPMGQYLFRRIRELGTEHILGVPGDFNLTLLDEIYNVPGLKWIGCCNELNGAYAADGYTRIKGVPGVLITTYAVGELSAMNGVAGAYAEHAGMIHVVGMPARAMQKARVMLHHTMEPNMNHAIYIKMADPIRKAHAYLMEDSTMADDIDRVIVACVHSRLPVYIYVPTDVVSVQLDAKRLETPLDFSLRNPDAKTEDEIVGKILSLVAAASKPSILADVLAIRHGGLELTKRLADITRFPSFSTPLSKGVIDETAPYYYGLYNGQASFPGVADAVEKSDLVINLGPLLSDSNTGGFTRQIKDENLVRLGHDLVQIKGEKFDGYHFLPILRRLVAEFEKQPQKYNLPRPQNGPKVEPPVLNTSTSGQLKQSFVWQRLGRFLKDNDIVLAESGTAQFGMPDATFPRNARYITQIFWSSIGYTVGSCLGALVAAKELKYPGRVVLIVGEGSMQMTVQEIGTYLRYGFKPIIFVINNNGYSIERAIHGPEQGYNDVSMLWDHQKMLEFFGARAGTGIKAKSRATKTVEELEAVLNDEDFGSGEMIQLCEIFMDAFDYPWRLSKQLEIARARMKQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM87</accession>
    <name>A0A0D2BM87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L33-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239936.1">
        <property type="nucleotide sequence ID" value="XM_016374660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM87"/>
    <dbReference type="STRING" id="91928.A0A0D2BM87"/>
    <dbReference type="GeneID" id="27327377"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00294"/>
    <dbReference type="HOGENOM" id="CLU_100745_2_0_1"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="109" mass="12385" checksum="34CC42D3B4E1FB21" modified="2015-04-29" version="1">MSSSTNHRLYVKGKHLSYQRGKRNTNPNVSLIKIEGVEDTEAAKFYLGKRVAFVYRASKERQGSKIRVIWGKVTRPHGNNGLVRAKFRHNLPPKSFGASVRIMLYPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMK4</accession>
    <name>A0A0D2BMK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_00390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="10"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240031.1">
        <property type="nucleotide sequence ID" value="XM_016374755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMK4"/>
    <dbReference type="STRING" id="91928.A0A0D2BMK4"/>
    <dbReference type="GeneID" id="27327473"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00390"/>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="400"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW19815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="836" mass="91269" checksum="C39122338EB9BEC5" modified="2015-04-29" version="1">MGSMPLQTTIDVEDVLSQLTTSEKVTLLSGIDFWHTAPVHRLGVPSIRLSDGPNGVRGTRFFNGVPAACLPCGTGLAATWDTDLIEKGGRLQGHEAIAKGASVILGPTTNMQRSPLGGRGFESFSEDPYLAGAMSAATINGIQSTGVAATIKHYVCNDQEDQRQAVDSILSERALREIYLMPFMIAQRDSSPDCYMTAYNRVNGLHASENPRLIQDILRREWGFDGLVMSDWFGTYSTTESIKAGLDLEMPGPTYIRGHLVNQAIGCGKLQVYDIDQRAREVLKLVKKAQSLGLPENAPEKTVDTAETSALLRKISSNGIVLMKNERNLLPFDKKKTTAIIGPNAAYAAYCGGGSASLIPYYAVSPLDGLQVQATDSKYALGAPGWKTLPLMTRLTKTKGDKPGLTMKVYLDPPSVKDRELVDEVYVNNSDILLVDYKNPEIKTTLYWVTVDGTFTPSETSEYEFSLAVAGTGKIYVNGNCVVDNETKQRPGDSFFGSGTAEEIGSLKLNQGETYNIHVEFGTYPTMKFNTKGATGFGAGGLRIGLERKVDIETEIERAVRLAKNADQVVLCAGLNKDWESEGYDRAHMDLPPGSDDLIKAVLAVNPNTAIVIQSGTPVAMPWLKDAPALLQAWYGGNETGNAIADVVFGNTNPSGKLPLSFPIRNEDNPAFLNYKSERQRAVYGEDVYIGYRFYEKTKKEVAFPFGHGLSYTTFEINDLSIDDDEANIVVSAAVTNTGNVDGAQVVQAYVSQRNPSINRPPKELKGFAKVFVKAGSTEKVRISFSKKYAASFWDEGRDSWTMEKDVYDVLVGDSSASTPLKGHFAVHETKWWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMV7</accession>
    <name>A0A0D2BMV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arp2/3 complex 20 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09741</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARPC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232680.1">
        <property type="nucleotide sequence ID" value="XM_016384057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMV7"/>
    <dbReference type="STRING" id="91928.A0A0D2BMV7"/>
    <dbReference type="GeneID" id="27336824"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09741"/>
    <dbReference type="HOGENOM" id="CLU_084855_1_0_1"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="200" mass="22682" checksum="B9082554EF3AA226" modified="2015-04-29" version="1">MVCLPCSTTTTLADHSQSQSLRPYLQCVRSSLTAALALSNFASQASERHNVPEIEAASSPEVLLNPLTVARNENEKVLIEPSVNSVRVSIRIKQADEIENILVHKFTRFLTQRAESFFILRRKPVKGYDISFLITNTHTEEMLKHKLVDFIIQFMEEVDKEISEMKLFLNARARFVAESFLTPVGIFEPGLLLANSRQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN71</accession>
    <name>A0A0D2BN71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240604.1">
        <property type="nucleotide sequence ID" value="XM_016375328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN71"/>
    <dbReference type="STRING" id="91928.A0A0D2BN71"/>
    <dbReference type="GeneID" id="27328046"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00963"/>
    <dbReference type="HOGENOM" id="CLU_018394_3_1_1"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="512" mass="55335" checksum="4B2F3FBC307FEDD9" modified="2015-04-29" version="1">MLLSSFKTADVFLHVISGSPNDDDPATSAKDAGAHGASGKKANRAVTLVFFVTGNPGLISYYRPFLESLVKRLEERKKRKKQGRQGDHGTPAVVVAGFSLGGFEAGRNHHNEGELDGGGGGGGGGGGGGGGDDDGQSATAKMRRELLMYPSGSGGGSRGGRHDGGDNDDDTEKIYSLKDQIELCYARIQRLCGLIRQEEEKEHELDEGERDRVRVRDGDVQHMSPPVKVILVGHSVGTYIGLEIVRLWHERSRKGSPSQHILEEEHDGHAGERQPPSPLPPPPATWAISSCILLTPTIVDLHASTSGRIATPLLTSMPVVSGYLPGLAHGFVRAVLIGGVPTTWLKGLVRKVTGMKEGHGLDATIAFLGSKTGVKQALSMAADELREIRADQWGDEVWGAAVDEEEEEEEREGNPTRTKREDEDEDDKVGTSTSTRSQNGPPRIYLWFAKEDHWVADMTRSEILKNRGRRGTAQGGPTIVIDETEGLVHAWCLEQSGMVAERVGGWLEEIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNC7</accession>
    <name>A0A0D2BNC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTP-binding protein yptV5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240236.1">
        <property type="nucleotide sequence ID" value="XM_016374960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNC7"/>
    <dbReference type="STRING" id="91928.A0A0D2BNC7"/>
    <dbReference type="GeneID" id="27327678"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00595"/>
    <dbReference type="HOGENOM" id="CLU_041217_8_0_1"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34699" checksum="F9FB3B05EAA97FAC" modified="2015-04-29" version="1">MNTAPPLITTTAPQPIPATSIEAKLVVLGAQGVGKTSLVSRFINPSAQLSKNVQSTIGASFVTKRITDPDTSTTVRLQIWDTAGQERFRSISRLYYRGANAGLLCYDITNEQSFEEMKTWLEEMKENCEDGEAMPIIHVVGTKSDIVADDPSRRQVTFERTITYVAQQLGAVAAESTASTPPLAMRSGNNIQSPDSKRSSGFWNQDIGWDSCHEVNAKDGEGVEEVFRVIARKLIDQKHQKDAAELTGLQGSRPRSDTGDDYFGGLHGHSGSFRVGYGDKRRSWLGLPSVGLGIGESESGGPGFGTRDPEEARRKGRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPB9</accession>
    <name>A0A0D2BPB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_01361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240999.1">
        <property type="nucleotide sequence ID" value="XM_016375723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPB9"/>
    <dbReference type="STRING" id="91928.A0A0D2BPB9"/>
    <dbReference type="GeneID" id="27328444"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01361"/>
    <dbReference type="HOGENOM" id="CLU_036731_1_0_1"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW20783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38840" checksum="4878D41063E3A410" modified="2015-04-29" version="1">MVHYIRFLRTPQTEVGKKTVGISAVVAVTTDLGDSLYPLDADLVVEVIETNRPFGVLHTQTIKWQAASRALKFTVNCPGKYMSRSARLHVTTKETASTIASLGIPEVLDVWSPAFTVADRQRTEPIVERQLLLPNKSRVCMWEETGDSIARHIWDASLGFLLYFAKALSPPAIQGATKLAALLMSSKVRRLRVLELGAGCGIVGIAFAQIVKCDMLLTDLEDAQEILASNVQSATPLAGSSISAEVLDWASSLDDSSNVNYDLFLVSDCIYNPDSSVHLVETLRQLATRAPNVLVLVGFKRRHEADTIFFERMRDTAFQVTETLNIALPHTVTDQDVNHPTVEFYTYVYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPL7</accession>
    <name>A0A0D2BPL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_01045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240686.1">
        <property type="nucleotide sequence ID" value="XM_016375410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPL7"/>
    <dbReference type="STRING" id="91928.A0A0D2BPL7"/>
    <dbReference type="GeneID" id="27328128"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01045"/>
    <dbReference type="HOGENOM" id="CLU_006072_3_1_1"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="183"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="629"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="729"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="632"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="773"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="798" mass="90060" checksum="5C0C312F4739D704" modified="2015-04-29" version="1">MEPQNSQNQSGKHQGGPESKSDINIEANPTSNDPTPPEGGLQLGGGQTIKLMLVPDKAPTPAPPKKKEKPHPQAKMTKFWDNFNPEYQGKVTRVLPERMTDKNVSLAKLVGEIAHRATTSYEHAKESCIRDVKRIIRECRESNQKYTDPHFDIERDLKITRARDCLDGLVIEQNDKEFPADVKRVTDIFDDPKFYVDGPSYDDILQGSAGDCWFLAAVSALGCNREFIDRVCVIQDQAVGVYGFVFHRDGEWHQCIIDDKLYLRAPNYDESGDVVLGQYGVRRNNQEDQYQELFQRGSQALYFAQCRDQNETWVSLLEKAYAKAHGDYASISGGQTGEALEELTGSITSEIYTTNILDTDAFWSNELSKCGKTTEFVFSCAVARWREWRPYLVANEKIREERRSGIVSQHAYAILDTYEGHGQRLVKIRNPWGRKEWTGTWSDGSKEWTPEWLSRLNHQFGDDGIFWMTYKDMLSKYKYIDRTRIFGPEWHVVQQWMSVQVPWSTLDYQTNYFSIDVPEDTEAVIVLSQLDDRYFKGLQGKYNFTLQFRVQKDSDDDDEYLARSKLNYELVRSVNVEVHLAKGTYSVLVKVEATSTSRDDVETIIRNNIHRRDKITQIGKLYDLAHQKGQLPGMSSTGTSLSPTGTSTPATTGTPVLSTAPATPTEETKPEEDAEKDPNRNPWNASCIVGLRVYSKQPDLALKIVVPSKEELSENKPTLDRDDVAKSALDEAQAAAEKVEESVKGDDDADDQGLPGQATKSASGKRVRLLVESSDEGQEEQGDASSSSDEESTVSYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ25</accession>
    <name>A0A0D2BQ25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">PV08_08421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233450.1">
        <property type="nucleotide sequence ID" value="XM_016382747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ25"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ25"/>
    <dbReference type="GeneID" id="27335504"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08421"/>
    <dbReference type="HOGENOM" id="CLU_055721_2_1_1"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="251" mass="27566" checksum="9AD99DF9472CBC7B" modified="2015-04-29" version="1">MTPSRSSSPEEQTDVFSLDTSLIPPRENKVAGTTSITFDGILPCCGTADSSYAHGAPLLLHEDLQEGCGGQLWPAGMVLSKYMLTHHKTQTLRGKSVVEIGAGGGLVGLAVALGCEVDADKPIYITDQVPMFALMQKNIALNNLQGRVKAEVYDWGTPPPAGMLAPGQYPDVVLAADCVYFEPAFPLLLTTLQDLIGPSTTCYFCFKKRRKADMRFIRAMMKKFAVEHVQYDGREADQREGIFLYTVQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQC9</accession>
    <name>A0A0D2BQC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PV08_01743</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 23">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241379.1">
        <property type="nucleotide sequence ID" value="XM_016376103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQC9"/>
    <dbReference type="STRING" id="91928.A0A0D2BQC9"/>
    <dbReference type="GeneID" id="27328826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01743"/>
    <dbReference type="HOGENOM" id="CLU_012062_7_0_1"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="20">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="19">
        <location>
            <begin position="307"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KIW21163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="558" mass="61871" checksum="AE72A7A385C708B8" modified="2015-04-29" version="1">MGKGTDKLYITHSEWASSDAYSASAGAGVRADTSGHAVFKRLPFNFCALSLQPFATPVCTANGIIFDHENIIRWLLKHDTNPTDGKPLKQQDLIKLEFAKNDSNEFVDPVTYKVFTDNTHIVAIKHGDSANVFAYDTVERLNIKPKMWKDLVSDQDFSRADIITLQDPQNIESRNLSSFKYLKEGEDSGIPKEEATINTASLGSAADLKIMKAKEAVAKARAERASAQSATAKDRSQLSSSTKKSTAASTYKPTPYNATGHTTGLAAASLTSTGMTPHTSAALALMSDEEYLLKRGRVKEKGYVRLSTSAGDLSLELYPEYAPKAVWNFIRLAQKGYYNGIIFHRNIRNFMIQCGDPTGTGRGGTSIWGKNFEDEFEGPLKHNARGVLSMANKGKNTNSSQFFITYRPTSHLDRKHTIFGRVVGDDGTSLDVLKRLEETPVDANDRPKEEIKIIEAVVLIDPFEEFWKNKAEKEQSEKEKEERKMEDRTTWTGKRIRDDGTIENASGGGVGKYLKAAMKNGPHEVEEDEIVEFIDEPEEPVRKKNKGGKGGFGNFDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQE0</accession>
    <name>A0A0D2BQE0_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PV08_01758</name>
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        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
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    <dbReference type="GeneID" id="27328841"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01758"/>
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    <dbReference type="OrthoDB" id="5313204at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="92" mass="10243" checksum="39F5F9F9211F6966" modified="2015-04-29" version="1">MDAIRAKLKRRMSHKDKEINFDDHDSADEETIDYVGKEAEDAEKEGYDAGRPGSFLNRLISHGNKKTEEQLAREAAAANPEAGGADRVVTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQX7</accession>
    <name>A0A0D2BQX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="91928.A0A0D2BQX7"/>
    <dbReference type="GeneID" id="27328526"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01443"/>
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    <dbReference type="Proteomes" id="UP000053328">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="240" mass="26506" checksum="EE42BF63EA32C0F9" modified="2015-04-29" version="1">MAPSDTTIIFVPGAWHTPDCFSPTTTLLEEAGYTIDLVYLKSVGPAEHVKDSQPDIDTTAAAIRRAVDRGHKVVLVCHSYGGIPGAQAIKGYESHIINFFLCCSFIIPQGKTLIGAFGSDLPWFNISEDRTEVNPATPAETFYNDMSEEQVKEAVSKLKPHSYQTFHSVVTYEGWRFVPTTYLYCLQDQAIPMFVQKLMVEEFAKGVDVKTPTVDASHTPFVSKPLETANAIRRAAGENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQZ2</accession>
    <name>A0A0D2BQZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241634.1">
        <property type="nucleotide sequence ID" value="XM_016376358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQZ2"/>
    <dbReference type="STRING" id="91928.A0A0D2BQZ2"/>
    <dbReference type="GeneID" id="27329081"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01998"/>
    <dbReference type="HOGENOM" id="CLU_062847_0_0_1"/>
    <dbReference type="OrthoDB" id="5428890at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="347" mass="39299" checksum="06950613471BB9F8" modified="2015-04-29" version="1">MKRLAPFFDHYRTWTALYGAETGGTGNALTKHQDLRNIIEKLHANPDVPRAELARIIFSAQPTSHPPSPSFSDRERALNLAVRVSAMINCSAVYQDLGVLEHGLLRQHWRGDISYSQFMSLLFPQIDHPTVNEDDSGKLPGFRTEVTARKLKKRARLRFQPTDDLRCHLQFHRKTRTVDIFHHTAFLKEQLRLTRDGAGDLLLSESLKLGALPRQLILEVLDSIQKVLFPLADEKSYALLQSLVSSSGFDPDCLRFESTSIRTAEETNISYHYLGARLAELYEESKNPTPHSLFDKWLERKSSARHVMLATLVGVFIAIVLGILSLAVSLYQAYVGYQAWKHPVPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQZ4</accession>
    <name>A0A0D2BQZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233820.1">
        <property type="nucleotide sequence ID" value="XM_016383117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQZ4"/>
    <dbReference type="GeneID" id="27335877"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08794"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="248" mass="26562" checksum="A4CF797A3CB32AA0" modified="2015-04-29" version="1">MPSYLVTGSSRGLGLGFVTQLLRNKDNIVVATARDTAGSSGLQELNARNNEGRLILIDLDVTKAESIKSAAEQTAKVLPEGLDHLISNAGVSGNLMRHVRDVDELVEEVKFPLVSLLLLVRGFLPLIQKGQAKKILVITSVVGSLTIAPLTENLGYGYGIARAALNMMARKWSTPLKAKGVTIALIHPGWVDSTDMGSSIVPWAEKNPSALSSITVEQSAAGVTKVLHDLKIEDTGSFYNYDGTTLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRB2</accession>
    <name>A0A0D2BRB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_02158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241794.1">
        <property type="nucleotide sequence ID" value="XM_016376518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRB2"/>
    <dbReference type="STRING" id="91928.A0A0D2BRB2"/>
    <dbReference type="GeneID" id="27329241"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02158"/>
    <dbReference type="HOGENOM" id="CLU_009388_3_0_1"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW21578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="74458" checksum="CB1FE806E2275716" modified="2015-04-29" version="1">MLKCAHRIMTHHRADMRKIEGNRSFTSILRAFRDGQNIICSIHTLVETLADMTAIATNHNTYVWAEGNHHFVFADDELHVKPPKQEALRMRLLERGWCPNDVEYITNTFALCRQYYISNLRRRASDKPHTACSSSLCFLKDNKSKFQQPKHRHSKCNCISISTQDDRVTASLKDGKIPRIHICPMLPMKDNTGQCEIKNSGKYVAISHVWSHGLGNSSANELPQCQILYLQQLVQNLYPPHHCPVHLWIDTLCIPAESEGKKLGLRLLKKAFHEADKVLVIDLELLDIHSVSDEEILIRINRSEWMRRLWTLNEAVISGPKLHVQLSQRAVDFKTLLGWHCPADGPPESSLPGPESVPDLDHDTAGHFAKIWAISMEKNLFRRLAKLIPVLHRRRVTDKADETICIATALGLPVEPLLDCHPELRMKTLISMLLKIPCNVIFSNAPRLGDIGLRWAPKTLLTGDLDFMNTNRAEQFYGSWTGSGISVRLGGFELHVYQKRFIRYLAHIPLKKFYFSYENKWLFATLVIPDGQETLAAVVTRPILRFALAVDPSFAQRRAILLGVHNEERHCIEVTYLARYNIGFLGDSFKQCAENIKRCAIESGYDLNPDISDMNQEERDSFEQINAAHEGLFALGASAAVNESYSLGQEWHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRI7</accession>
    <name>A0A0D2BRI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234085.1">
        <property type="nucleotide sequence ID" value="XM_016380983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRI7"/>
    <dbReference type="STRING" id="91928.A0A0D2BRI7"/>
    <dbReference type="GeneID" id="27333733"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06650"/>
    <dbReference type="HOGENOM" id="CLU_318320_0_0_1"/>
    <dbReference type="OrthoDB" id="4159571at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="943" mass="101126" checksum="D40A90429A2C610B" modified="2015-04-29" version="1">MDPESSDSDVSVGGGDEYRYASPLTAPIPLPAPPSKHALESADAVQARLDELSRVETNNEKKYSLLKAKRQRKDDKIRRKREAQDKKWLAITEARKRRDARIAARRKREDAAFTQFFEHDLDEEETNLRRRLKRLKRGLPLDESPKASTRSVSGPSMSPPASLSTIPPPAKRHQVGPPGQPDSVNSAQSRPSPQSNMPGSSTKSSLPGPPYSFYRDPNSAFSRPYQHGSYSSSPNGQSPTTGTNRLPDPAPAPPSHDRPLGILGRATSPRPRPSGNAQSPLTPGSSTNTQPPRQTSSSYDTRPPPTNTGSGFASINAPPSGFASINARPTSTPPAAHTPMTRPQTEGDVNRTPIGSHPNGGLDKDRFQQYGHTPTGVPSPGTSNSGSKRTPSTTHPYQMSEAFANRHHHCERVDSLNRGIWTSYGPGGTAENPTSAAVEMYLRCNHDNCSRIDWRTVHGLQCHIVKNHSQPKGTIGSLDKALERYGIPVKEVEDYEREHGNGSAGTMADPKNHKIKVKTKEATGLETRPYVRKDTPGVYDPDARPAGYRPSPAESPALSDDIKQSPTVSMNGFSREATTEESRRPPSQTTTASPMNTYSSSSNWYRNPFPGGLPPLHADLEPKRLQGDFGASEAAVKSSQPPPLGHHHQQAGSNLANGIQNKSPPLNTLPPPPKSSNTISVADTSKAASNIDASPVPSASSLAPTIPTTTEAPQAAEVPADANKDLPAHKEIAPSDALPAKPNGPAPGAATADPDVQMTDVDQQLQKENGNEKPTEISNGTVVGDDKQATPAAEVSSVPKVAPSGPDGEPVPKSEPGVSSQAPEEADLEDQSETIVVDGETGKEAGAAKRNAPSTNGPFQSPVMTTRSVQAAGSNVTTPTRRGSRRSSVVRKSVDRDGDNNLNSNEGRADKENEDKDEKDVREEKVERETRRSITGRLLRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSP0</accession>
    <name>A0A0D2BSP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241656.1">
        <property type="nucleotide sequence ID" value="XM_016376380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSP0"/>
    <dbReference type="STRING" id="91928.A0A0D2BSP0"/>
    <dbReference type="GeneID" id="27329103"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02020"/>
    <dbReference type="HOGENOM" id="CLU_067597_0_0_1"/>
    <dbReference type="OrthoDB" id="5378435at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="362" mass="39882" checksum="A41BCC7FEC393A18" modified="2015-04-29" version="1">MEYAPLWNYSLPETAYNPASMSVSSYFARPNRVVKPSSRNSSPRNSGRRKTTTGATLSSRTRSLVDHLRSRSQQQPDFDNSRSRPVSWHTTYDGLHIPFDSCTPEYDSSAWDFTTTQVNGLVTPISHPVMNEPQIQELMTPLDEVNAANIVIGHGSQHCLNQVWHDDKHSKFDRYTFAPFDSSLYSSQPAMVSGVATAPPSPSYPSASEINVQDLSLDSSDGKAQDNREELVGMGLYDSPAQVQSSSLLLGNFAGSGQTSLKLAESFEPVEWDPAADQDGEAEGDDDDDEVEMDEDIAQQHNPTPLDTSATMFSSYDSQSVANHMAFPTPSGVDPLAYKYLATLSQLNSAYYPNCQYGYGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BTN1</accession>
    <name>A0A0D2BTN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234805.1">
        <property type="nucleotide sequence ID" value="XM_016381703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BTN1"/>
    <dbReference type="STRING" id="91928.A0A0D2BTN1"/>
    <dbReference type="GeneID" id="27334456"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07373"/>
    <dbReference type="HOGENOM" id="CLU_760757_0_0_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="386" mass="44546" checksum="41B1EBA2FE83A020" modified="2015-04-29" version="1">MPRHDWSNVTYEPINGNIEEIDIWTRGPNRELIVRPGHQTSSASIPPVDPHPAPVWWVPPVASSPAVQWLVGQPQTGTAEAPVINNTPSSAPINVHDFANAASNSAAIASIEFNGQRSNLFSANGPYPDPYWWHHVPHHPPLESEEAIVRAHVLAEENDKKNASEQAVQKYKLELAEAEKVKQRIINEHELEMKNKEEDTRRLKDFWEAQQKAEQLKKENEKKKQEEDLKNEMRKKMVDHGFGPDEIEQAISGKPYHPTHHLNPVPYTHSSSHAHQHSLCADLSCPGLGLSDVEYVRVRWEQLNTETLDYFGIPWKFDSDDREVILILRPKSSLNIQDLFSHTREHYDFDVLMRVWKRKAVIEVRPTKKKKKKKKKYRLCLIREPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZ14</accession>
    <name>A0A0D2BZ14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236740.1">
        <property type="nucleotide sequence ID" value="XM_016380913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZ14"/>
    <dbReference type="STRING" id="91928.A0A0D2BZ14"/>
    <dbReference type="GeneID" id="27333662"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06579"/>
    <dbReference type="HOGENOM" id="CLU_022796_0_0_1"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047669">
        <property type="term" value="F:amylosucrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11324">
        <property type="entry name" value="AmyAc_Amylosucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044077">
        <property type="entry name" value="Amylosucrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF213">
        <property type="entry name" value="ALPHA AMYLASE CATALYTIC REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="109"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="636" mass="72699" checksum="C782533C32E464B6" modified="2015-04-29" version="1">MSNHLSIEQQARAAKAYVIQELGKTSVGESILAEEAFYRRLDMNFITIFAIFAELYGYRHDCLDQLVDLITMCGKSWMARDLELQKLDQERELDPEWYLSNQMLGGVCYVDRYAKNLDGIRSKIPYFQELGLTYLHLMPLFESPKPLNDGGYAVSSYRDVEPALGDIHQLKALATDLRKAGISLVLDLVFNHTSNEHRWARKAAEGDPEHSAMYWIFPDRNVPSAFERSTREIFPDDHPGSFIQLPDGRYVWSTFYHFQWDLNYSNPAVFRAMAEEMLYLANIGVDFFRMDAVAFMWKQMNTDCENLPEVHKLLRAFNALCRIAAPSVLFKSEAIVHPDFVVQYIDRYECQLSYNPLQMALTWEALATRDASMLAQAIERRHNIARGCAWVNYVRSHDDIGWTFSDNDALELGKQGANHRKFLNAFFVNRHPGSFARGVPFQDNPRTGDCRISGTTASLAGLESGQDGALERILLAYSIAMSTGGIPLIYLGDEVGQLNDYSYLNDPSKMDDSRWVNRPWYPEQRYNERHDQNTIAGRLYAGMKHLIHLRKTTEEIAGGRAIGFYTGNPTVLGYQRPGSNSNLLCLCNFSDTPQWVGRDRFMGLPESAYDLVGGYNVELRSAGIQLRAHQYVWLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZH4</accession>
    <name>A0A0D2BZH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236945.1">
        <property type="nucleotide sequence ID" value="XM_016378268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZH4"/>
    <dbReference type="STRING" id="91928.A0A0D2BZH4"/>
    <dbReference type="GeneID" id="27331001"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03918"/>
    <dbReference type="HOGENOM" id="CLU_538610_0_0_1"/>
    <dbReference type="OrthoDB" id="5424234at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="52850" checksum="F342CDB3A8435DD7" modified="2015-04-29" version="1">MTAILPRGLIDTIPAVEQDVFGAVDSVADNAEALHHFWRYFAVQSDLSGDPKCTRARNLFWRIWSDPELFHNMTVPRLMQLWRRCEDQFDLRPIGHINVSSRVQQLSTSGLTQELTPSMVPASESPSPLSHPIDPNYLETFPPLCQEPPGRRLQYDSSNELIPIRDQSSARTSAPASNTASGSSSRPALSRTTSGSRSRIPIVATAGRTRTKPQLGRRKSSSSRATSTIPNAPKPSRTPTEPFGRASASASSSHAAGRASTRGPPPGLLNPPAMRNSANFLVASPSSWQSVGSRTPTPPTGVTAPATTSADLVERDFRGKFVEAQKRLNSFTNLPVLMRMPKNKSVVRFVDENPSDEGKGKGKAILAESPEASMGAPSLWSSIHASPSASDDEGSSDDAVELPRTKSQLSMLIKHKRAQTGSQDLGPAISLVEPSARARDKDKGKAKEEELLSMARRDGVTKAGGVQVPASHRISGDDPGYLSPSSPEPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C4Y9</accession>
    <name>A0A0D2C4Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238875.1">
        <property type="nucleotide sequence ID" value="XM_016377305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C4Y9"/>
    <dbReference type="STRING" id="91928.A0A0D2C4Y9"/>
    <dbReference type="GeneID" id="27330031"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02948"/>
    <dbReference type="HOGENOM" id="CLU_008292_0_0_1"/>
    <dbReference type="OrthoDB" id="2117591at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017210">
        <property type="entry name" value="APP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037464">
        <property type="entry name" value="UCP037464_APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="353"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="848" mass="93157" checksum="E5BDAB464A1EE137" modified="2015-04-29" version="1">MTSYGQSGARVPGSRRDKVRGYLKAANELRQIYQDQISQKLQGSETDGSMPGDFPDVDIVRSGSEEMLLFPSYATTHRKRNTNSTEGGRYLPGTNESIESPQSSGDADYWKREWEKYEDANAVVDVDVRGWIYSPPSGPLNRKNRLLLAVARRLSGVYAPLPDQTPSRSSSQAPPGQGWREDSPSRYEDEIAAREAENIARHGELEADAAQRGSYSQESGNGSHGRGGGNGSLTQHNRPSTNDSTYHDPGQDSLKRRESWNEPANMNREELAAANKLLLTRLKPFMTTPVAHTPITVFFFNDQKSTSKSVTTDESGHFNLRAALDFIPAQVRVLASDKLSATEDVVVTESKGISLISDIDDTIKHSAIASGAREIFKNTFIRELGDLTIKGVKEWYAKLASMGVNLHYVSNSPWQLYPLLRSYFALAGLPAGSIHLKQYSGMLQGIFEPAAERKRGTINRLMNDFPDRKFILVGDSGEADLEVYTDVVLEYPRRILGVFIRDVTTPPKRGFFDQAVSNTTPDSMISSENGSRLPRSNQQHPASEDRPALPTRPKPEHKSHSMPPREEDLIDFGDEPESESSKTTRSHSDDLKLLNDKPAAPAKPNKPSSLRNFSTASMQSTNHDRLSASDTEVHEPGKKKPPPPPKPRRGGGSTRSESSSLAPLQRAPFSSTRQNQSATNVTVSAKGPAPTPPMTRTNTSASTVSSQSSTYDEGYLASARRQISSAYNALPPLRSTSPSWAADQTGISGDHRQNPPLPPRRGLSSYPAAAARWATGATGGDPAAGGDGGMPGGTYDKKLEIWKRRWARAEEIMHQRGVFLRTWRVGGDVMDDCVRLVKKELEKSESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CB59</accession>
    <name>A0A0D2CB59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphosulfolactate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241015.1">
        <property type="nucleotide sequence ID" value="XM_016375739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CB59"/>
    <dbReference type="STRING" id="91928.A0A0D2CB59"/>
    <dbReference type="GeneID" id="27328460"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01377"/>
    <dbReference type="HOGENOM" id="CLU_062679_1_0_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413:SF1">
        <property type="entry name" value="PROTEIN HEAT-STRESS-ASSOCIATED 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="(2r)-phospho-3-sulfolactate synthase ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35275" checksum="829BB44BDC321E25" modified="2015-04-29" version="1">MASKAAGSLISKAGRPASRIQPPQSHRLLSSNPVQAQAQTLLQDKENGFGFIRHNPRTPKPRTQGVTEIRGPYYSAYGKRHLQDVLETMGYHIDGLKFAGGSFSMMPEHAVRELVDLAHEHQVYVSTGGWMEHVLTQPDAPTAVDKYLKKCKNIGFDVVELSSGFLSFPPDDWLRLVDKVHSMGLKAKPELGIQFGAGGDTAAEDLEATGTSDPSKVINLGKKFVEAGVERMMIESEGITENVKSWRTDVIQATLRDLPREKVMFEAADPPVFNWYVREFGIDVNLFVDHSQIVQLTCLRSGIWGMADTFGKIVSYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCB9</accession>
    <name>A0A0D2CCB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241350.1">
        <property type="nucleotide sequence ID" value="XM_016376074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCB9"/>
    <dbReference type="STRING" id="91928.A0A0D2CCB9"/>
    <dbReference type="GeneID" id="27328797"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01714"/>
    <dbReference type="HOGENOM" id="CLU_049109_3_1_1"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW21134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="196" mass="21546" checksum="F7B5FE2FE442C1B9" modified="2015-04-29" version="1">MATRIVSVTVQGALLAAASNAIAQGFTIYRERSLSAFDPSPFFQFVVFSILNTPPNYMWQLWLEENFPGTAKKEEKPASALDEKKKAKSDGAKLDEKDTESLSITNTIIKFVLDQSVGAVYNTAAFIVIIGLLRGATYTQTVDALKRDFWPMMIAGYKFWPLVSLLNLAVVPVEQRMLVGGLAGLAWGVYVSLMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCS3</accession>
    <name>A0A0D2CCS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TspO/MBR family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241515.1">
        <property type="nucleotide sequence ID" value="XM_016376239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCS3"/>
    <dbReference type="STRING" id="91928.A0A0D2CCS3"/>
    <dbReference type="GeneID" id="27328962"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01879"/>
    <dbReference type="HOGENOM" id="CLU_091805_0_0_1"/>
    <dbReference type="OrthoDB" id="8841220at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23327" checksum="95979DEDD02199CB" modified="2015-04-29" version="1">MSYIPGLTLPSSVFSNAPISILLPLGLGLGSGLISQPGRMRPKTFSDPSAQARGKFRTTEEQYKALKQPPFRPPPYVFAPAWSMLYLMMGYAAHKAWTTGMSSLSPRVVEDTRRGATLYTLQLGLNLIYMPLFFGLGRPIEGMLDVVTLTGTVGYLTYVWSKVDKTAAYLMAPYLAWLGFATYLTAGTGHLNGWTIPSPEQKEETAMDKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIH2</accession>
    <name>A0A0D1YIH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234952.1">
        <property type="nucleotide sequence ID" value="XM_016381850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIH2"/>
    <dbReference type="STRING" id="91928.A0A0D1YIH2"/>
    <dbReference type="GeneID" id="27334603"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07520"/>
    <dbReference type="HOGENOM" id="CLU_011226_14_0_1"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10291">
        <property type="entry name" value="GST_C_YfcG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000172">
        <property type="entry name" value="Glutathione S-transferase GstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="96"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="29106" checksum="3AF4F43D3B7DFB20" modified="2015-04-29" version="1">MSRPDITLYTDSTPNGIKISIALEELGIPYKTEHVNISTNRQKEPWFLEINPNGRIPALTDTFTDGQKIRLFEAGSILTYLAEQYDTDHKISFPKGSREQYEMNNWLFWQNAGLGPMQGQAHHFVRYAPQKIEYAVNRYVNETRRLYGVLDKHLESSKSGFIVGDHISIADITTIGWVMSAGWGGLDIDEFPTLKKWEEMMSERPGVKKGCEVPKPFSIKERMKDKKALEEYAKKGSKWIVQGMEDDRKKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKQ7</accession>
    <name>A0A0D1YKQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-hexosaminidase</fullName>
            <ecNumber evidence="6">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_05624</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="6"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235792.1">
        <property type="nucleotide sequence ID" value="XM_016379965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKQ7"/>
    <dbReference type="STRING" id="91928.A0A0D1YKQ7"/>
    <dbReference type="GeneID" id="27332707"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05624"/>
    <dbReference type="HOGENOM" id="CLU_007082_0_2_1"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF58">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002247056" description="Beta-hexosaminidase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="9">
        <location>
            <begin position="225"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW15576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="492" mass="56538" checksum="492A0E6D86975EF5" modified="2015-04-29" version="1">MHFHLWVFFVVLRPIDAIWPEPAEWSTGSQVSWLGDAPEVTLRCEDRSSILQTRGRQRPKNHFTSLMYNLLYPAEAVWSHFQSLPEQENWQVDGKDFSENYILHEAAYETINSIQNSRFVPWKMHKRNEAFEPHPDSPRHELLALQIQLSLCPRNSTFDPDTFFDGDESYELAVANETAILRSNSTLGSLRGLQTFKQLFYAHSSISGVYIPYIPVHISDRPKWRHRGLSIDIARNPFKPQDLIRTIEAMATTKMSRLHVHATDSQSWPLEIPSLPDLARKGAYHPDLVWTAEDLKGIQLYGVSKGISVFIEIDMPGHTASVAHAFPNLIAAFDELDWSTFAAEPLSGQLKLNSTAVYDFLQDVLTDLLTRTSPYTSFYHIGGDEVNLPAYLLDDTVRSDDPAVLQPLLQQFVNHAIALCAKHRLQPIVWEELVLDWNLTFPSAKDTSKGTLVQVWRNSNRIEEVLKKGHRVVFGDFKHWYLDCKRFKFWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKT8</accession>
    <name>A0A0D1YKT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05674</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235842.1">
        <property type="nucleotide sequence ID" value="XM_016380015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKT8"/>
    <dbReference type="STRING" id="91928.A0A0D1YKT8"/>
    <dbReference type="GeneID" id="27332757"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05674"/>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_1"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="396" mass="44704" checksum="09FB00EF613AD583" modified="2015-04-29" version="1">MLKKNIIIIGAGPSGLTLAALLQHHSIPFTLYEREPNISSRFQGGSLDLHPESGQRALRTAGLEASFKKHARYHDQDYRFMDKHAKDWLFHQAPPDAEGRPEIDRSELRKILIDAIDPENLKWGHHISKITKTADGKYEVHFENHDTSAVGDLIVGADGTWSKVRTLLTATRPVYTGLTVIDCRISNLDKKFPELGKFIGRGTVFALSDGSGIFMQRNGDDSLRVYPCLKVPEKWAFESGIDWTDQKNATKMLLEDVYSDWDGRLKEVILSLDPKWNPRAQYRMPLGMRYETKPGLTLIGDSMHVMSWFAGEGANLAMLDALDLFLCIQKDPADLVTAVRNYEERVMGRADSTNKMSQDLLEEAMADDSPRAYVESMSKAMDIWFADGRLLEDVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKX7</accession>
    <name>A0A0D1YKX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05731</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235897.1">
        <property type="nucleotide sequence ID" value="XM_016380070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKX7"/>
    <dbReference type="STRING" id="91928.A0A0D1YKX7"/>
    <dbReference type="GeneID" id="27332814"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05731"/>
    <dbReference type="HOGENOM" id="CLU_001858_0_0_1"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="876"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1279" mass="145139" checksum="16DA75E03EB7D6C3" modified="2015-04-29" version="1">MHYGKHASRSAALEESSSDAPDKQCKVKAADLGFDVPEYILPDIIPISDSRSDYLNIHHQRDRRLRLLLRRFTNQIQYGCRNSNCTTPTCLSYRKRNSTGPLRRYTDLSARTLACQLLEDFSRGGKEPLAELCPNEPVVPWYEDPAVAKRRRTSLDKTSYLPNGHSTPSKSQPQAQRVRNTSPRSQSATQERGNLNHDGVVQAGRAIRGLDISKEPRELSGDVIDVVNSALSGQQNAGERREEYPTHNSIIPDTHAAYRSPDPVRSKDIASFTQTLFDLLPLRLLDWFPSKSLRSHDDLTANTHVSKGDQDERMPGEMTKSDDEQRGSEHPDSSKSHSTPLRPSDTTSQEARNATSQDHEAEGCRRPQLYSLRTLNWLSLPWLRHMEMEKVSIYKKSLLPFFRQSCSYCLSHPHRLIRTVVDLQKSHPRSFGLEDGDALDNSTDSPPGNTPDDGPKLATQFRRDLDGILSSLALLDAFEQRELVLGCILTALQHAYRLPRGVAAPRVGRRSLSITESDEKASANSRAHSFVQSDFSSDEGMDISTIFQQKDDSLLPLSDHHVVELCLVGLLSIASLAFSGYYGRFWGSKAPFDRLATIRNSGLAHSRWQSLDPRDDKEETQHFISVMIWALDVFDDWSVLRLLYAITDIISHRLLMEKSSATMRDPILTGLKRKKKKNLVTLLVQRFDKDTLRGWNSSDQRSSWIGTVVIELLRTVLLKAWDRKAVVQRNGSVGGTLELLAGLFHERKQLNLTAELFQMPFIADVFDEAAMPREWLSFRADTRKMHLLSFSFLFEPATLVKYFRAINLDIMKKSYESATLVYGDARQYLWAPKIPVYGHKEILAQLRPHMARYFVLTVRRDNLLNDAIDQIWRRQRMEIMRPLRVRVGKDEGEDGVDYGGVQQEFFRLVFAEAFDPDYGMFTVDSSTRTAWFQPGSFEPLYRFEALGILMSLAIYNGITLPVTFPVALYRKLLSLKVKKLDHIADGWPELARGLKTLLEWSDGDVGDVIARTYEFSYELCGSTVTVDMLKIGREDPWPQLTLRPNRKGKEKAKSTSFELPLEPSLTPPSLPSPDLRPAITPIHGKSSINIKGISTPQSINSDLLEEAALVTNANREQYVKDYILWLTHKSVQLQYEAFAKGFYTCLDRTALSIFTPEALKTVVEGHPEIDINELEHTVTYEGYDRDSEYIQDFWRVVRDFSPEQHKQLLEFVTASDRVPVNGLGSVQFVIQRNGDDEDSRLPSSSTCYGRLLLPMYSSREILRDKLSKAIENSVGFGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YL45</accession>
    <name>A0A0D1YL45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235987.1">
        <property type="nucleotide sequence ID" value="XM_016380160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YL45"/>
    <dbReference type="STRING" id="91928.A0A0D1YL45"/>
    <dbReference type="GeneID" id="27332904"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05821"/>
    <dbReference type="HOGENOM" id="CLU_018204_3_0_1"/>
    <dbReference type="OrthoDB" id="10016597at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="266"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="427" mass="46110" checksum="528B488EC48724C0" modified="2015-04-29" version="1">MVSFTIDDRQKALIQEVRAIGKDVLAPAYEVYSKHPDQLSRFHATKPFYEKAIKAGVLQLLIPAAVGGRSQTFLDCAIVLEELHGIDSSIMVHAIGTSLGLLPLILAGTPEQKEKYLKPFLKAEGTPLASLAHSEPGGTANFLEKGGKGLGVTAQKEGDFYVVNGEKRWTTNLAGWDGKGADLACLCVRLSEDGGPEKPDATPADNVMILAITRDIVAQNSPEAFKVLSEPDLSGHTGATGPHTRYTNFKVPADAVLFAPGAATPVIEQAFGVTAALVGAMAIGTMRQAFERALDFAKRDDRGGTVPIIQRQSPADLLIDAKIKIDTSRMIVWKAVDALENGPGTPSQRFETCLEAKIYPSDVAPTCVWDCMRVVGMTSYACDTVFPRLLNDATCYALFDGGNIGIRRRQFERLLAAKDYDPWANFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YLE4</accession>
    <name>A0A0D1YLE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236072.1">
        <property type="nucleotide sequence ID" value="XM_016380245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YLE4"/>
    <dbReference type="STRING" id="91928.A0A0D1YLE4"/>
    <dbReference type="GeneID" id="27332989"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05906"/>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_1"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000145">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="7">
        <location>
            <begin position="589"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="698" mass="75995" checksum="AA874684B03EA88B" modified="2015-04-29" version="1">MRALLRPSGPFRWGHTPRARSTGLHLRSFAAVADATRPYDVVVIGGGHAGTEASAAAARSGARTALVTPSLSNLGVCSCNPSLGGIGKGTMLREIDALDGVAGRVVDKAGIQFRILNKRKGPAVWGPRAQIDRDLYKRYMREEMLATPNLSVLEGKVADIIVSQDDLDPKSTISKGRITGVRLEDGQIIPASHVVITTGTFLGGEIHIGLEAYPSGRMGEAATFGLSKSLRKAGFTLGRLKTGTPPRLDRDTIDFSALEVQPGDSPPAPFSYLNKTVQISDEGQLSCWTTYTNEASHDIIRANLDKSIHIRETVKGPRYCPSLESKIIRFGHKPRHMIWLEPEGFEPNNIIYPNGISMTVPADAQYAMLRTIQGLENVKMLQPGYGVEYDYIDPRNLFPTLETKLIQGLYLAGQINGTTGYEEAAAQGIIAGINAGRASQGKGSFTLSRSEAFIGILIDDLITKGVSEPYRMFTARSEYRMSCRSDNADLRLTEKGREAGVVGDKRWAHFSSIRDQMAELQKGLEEARFSSQEWQRLGIQSRIDSTKKSAFDLLRSPGVTIDLLSGRIDSLPSASNYEDNVKARVQIESIYAPYIGYQQRAALAFERDESLELPLDIDYDQIHGLSMGEREVLKLVRPSSVGMARRTEGVTPAGALRLLKHAKRAGSLVSSVSRDPPVASEELLQTERAGAEGGIGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YLS6</accession>
    <name>A0A0D1YLS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-glucosidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236192.1">
        <property type="nucleotide sequence ID" value="XM_016380365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YLS6"/>
    <dbReference type="STRING" id="91928.A0A0D1YLS6"/>
    <dbReference type="GeneID" id="27333109"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06026"/>
    <dbReference type="HOGENOM" id="CLU_000631_7_3_1"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06591">
        <property type="entry name" value="GH31_xylosidase_XylS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051816">
        <property type="entry name" value="Glycosyl_Hydrolase_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863:SF2">
        <property type="entry name" value="MALTASE-GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="4">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="231"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="577"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="76179" checksum="126895D016FAEFDD" modified="2015-04-29" version="1">MLLSKDDALHYTYDSEHVQIEAWGPNALRVRATKLHTWPSGDWALTIAPQKSKPTITVQDKSAEITNGGITASISSRGKIIITNAKGERLLEEYQRNRLDVEDPKCSALEVEAREFKPLLGGDYHLTYRLESVDKKEKIYGMGQYQQPFLDLKGLDLEMAQRNSQASVPFMLSSLGYGLLWNNPAVGRAVLGKNIMSFEAQSTKFMDYWIVAGDTPAQIVEAYADVTGKVPMMPEYGLGFWQCKLRYQTQEELLGVAREYRKRNLPLDVIVVDFFHWPKQGEWKFDPTYWEDPDAMIKELQAMKVELLVSIWPTVDKRSENYNHMLEHGLLIRQDRGLRVSMDFQGDTVHADFTNPAARDFVWKTVKKNYYDKGVKLFWLDEAEPEYNVYDFDLYRYHSGSVLSTGNAYPVDYARAFYEGMVKDGKQKDVCNLIRCAWAGSQKFGTLLWSGDIASSWSSFRDQFAAGLNVGIAGIPWWTTDIGGFHGGNPTHPEFRELCTRWFQYGCFCPVFRLHGHREPMQPQHGTTGGATCISGAPNEVWSYGEECYEIMKKYLLLREKLRPYVRQLMTQAHEKGTPVIRTLFFEFPKDQACWDVEDQYMFGHKYLVAPVMYKGVDKKTVYLPKGATWRRFDDGEIKDAENLPGGQTIDVSCPLAVMPVFERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YM40</accession>
    <name>A0A0D1YM40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236277.1">
        <property type="nucleotide sequence ID" value="XM_016380450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YM40"/>
    <dbReference type="STRING" id="91928.A0A0D1YM40"/>
    <dbReference type="GeneID" id="27333195"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06112"/>
    <dbReference type="HOGENOM" id="CLU_018406_5_1_1"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="14"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="529" mass="59416" checksum="BB3E93DC59CF1BCA" modified="2015-04-29" version="1">MASASVQQQVIRDDSVHIRSSAGGGRSVHAARDFEAKSQIMFVAKPLLVALNTANLIANCYSCLKPPRELQPGSNGQDSTLKKCGGCKVVRFCNQKCQKLAWSQYHRLECKLYGNLFPRILPSNVRAMIRLLKQHKAGLLLAGEWDQLLSLESHVDQICSAGGERLEDLLLMTQAIKSYSGSDLDPQLILRVLCTLTINTFTLTNPQFEPIGLALHPRTSMFNHSCVPNAYVRFDVSRSDSLSRPADSHGISVHALQPLQKDEEITLSYVDGKYPFEQRQRELKERYFFICACELCRSEKNAPVLPSRTSQKAKSVESHAERVLSKVQSAPVVSLQHIDEIRTAMVAFAEPGCWPLYHYPWLQLRHELLQGLIGSTKYSDALLQSAAITRYIHPAVYEQPHHPIRLTQMWTLWNLCRTCVEAGFHPTDRAQDSRSLHMLNMLSCIVIDDLNKVLTDGIRINGEIEYGVDEALQLVAGRAGMWGEYQRAPTVARKNVWAWLENEINCQLKKEGVSQTLIDEVSLNQGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YND8</accession>
    <name>A0A0D1YND8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-methylcrotonyl-CoA carboxylase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_03769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236797.1">
        <property type="nucleotide sequence ID" value="XM_016378120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YND8"/>
    <dbReference type="STRING" id="91928.A0A0D1YND8"/>
    <dbReference type="GeneID" id="27330852"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03769"/>
    <dbReference type="HOGENOM" id="CLU_000395_3_1_1"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="39"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="155"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="643"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW16581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="80022" checksum="9DAC19476A39865A" modified="2015-04-29" version="1">MSHLRLPRTPAWRARPAVQSYVNRQLRRTHADHQHNTKSLDSILIANRGEIALRVNRTAAKYGIRTTTLYTDPDARSQHAHSSPFSFNLGATAAYLDQEKILSIAKEQGCQAIHPGYGFLSENADFARRCAEEGIAFIGPPASAIEDMGDKARSKEIMNAAGVPCVPGYHGSDQNPDTLAQEADKIGYPVLIKAVRGGGGKGMRIVKNAQEFSDMLESAKSEARNSFGNDEVLVEKYITTPRHIEVQVFADKHGNCVALGERDCSIQRRHQKILEESPAPDLDDVIRKDIWNKARAAALAVKYEGAGTVEFIFDNDTGEFYFMEMNTRLQVEHPVTEMVTGQDLVHWQILVAEGRPLPLTQAEVEEQISQRGHAIEARIYAENPDKGFIPDSGKLIHVRLPIETEDVRIDSGFVEGDIVSSHYDPMIAKLIIRGPNRTDALRKLALALQDYEVAGPATNIDFVRRVCRSPDFISGKVETGYIEKHRQELFAQAPVTPEVLAEAAIASYLHNSSHNTNNTVLPVSAQSSTSWLNTTSDFQPRNFHFQSADFEPGPGKSPDVHSIEVHQTSPGQFLFKQPSDTTATTVSSSLDPSTNTLTTYFPHTRHTSRVIFAPSSPVSSGAIHLFTPDGSFRLLPCQPSWLAKALGVTEKANSLLSPMPAKILRVMVKPGDVVTKDQPLLVIESMKMETVIRSPASDMTVKRVVHGEGEVVGSGVELVEFEAEATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YU18</accession>
    <name>A0A0D1YU18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238972.1">
        <property type="nucleotide sequence ID" value="XM_016377402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YU18"/>
    <dbReference type="STRING" id="91928.A0A0D1YU18"/>
    <dbReference type="GeneID" id="27330128"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03045"/>
    <dbReference type="HOGENOM" id="CLU_110355_2_4_1"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="9"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="110" mass="11829" checksum="6E55438C5E53028D" modified="2015-04-29" version="1">MSSTSTKEWLVHVPDFPGALEKRLAARPTHLGKLKPNVEAGKVVFGGATLSKQPADGEAPDMTGSVMLFKADSEEEVRKALEEDAYTAGGAWDVKNATIWPFKCAVRTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVU6</accession>
    <name>A0A0D1YVU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239617.1">
        <property type="nucleotide sequence ID" value="XM_016378047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVU6"/>
    <dbReference type="STRING" id="91928.A0A0D1YVU6"/>
    <dbReference type="GeneID" id="27330779"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03696"/>
    <dbReference type="HOGENOM" id="CLU_046457_0_0_1"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52193" checksum="A24A1423E1527BE8" modified="2015-04-29" version="1">MSIGSDSQSSSQHLSSSQASLNQSSKRTSSEISKIYKHASQLFLTRRLLEAYEALQPIVTPPGKKRPDDSPAQAPVATATTSQRIKIWSLYVTLLNSIVDLGYEEGGNTFGQKYYGDIVRNVRNGNIWDQVVRDGYQGREGSVDAEVVYNLSNLLLGQAPDQKVNQSRLETYLSSSQTDLDISTHLSNALSNGRQPGMNGTNTPKDLASRIKVLELFTLHVLPRNEEWDYAKSFISNSDILDEERREAFMQTLLELQEVSEGRDNAEEVEEDVFEDTEEAPYPHETASSEQNHVHESTQPLKTTSKHQRTSSEVDYGIEKEHPNGTHNTSIAQAVKLPKEAPLNSLPPQPLPSSLSPRPPPPPASAPSGRSTMSPPSQPPRRSTRKPKASKQNAMLAQARLLFTALSNLARNLAGTISKNPTNILRMLLFILAFVMAFSQKQIRQKTRSLVNTSWNKVRATIGMGTKVSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWN8</accession>
    <name>A0A0D1YWN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_00290</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239932.1">
        <property type="nucleotide sequence ID" value="XM_016374656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWN8"/>
    <dbReference type="STRING" id="91928.A0A0D1YWN8"/>
    <dbReference type="GeneID" id="27327373"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00290"/>
    <dbReference type="HOGENOM" id="CLU_013299_3_2_1"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="90"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="376"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="376"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW19716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="441" mass="48515" checksum="7E6D89BF2E22ED69" modified="2015-04-29" version="1">MATLSPAENPPSPVPHVPIPKNGVDYRGKVVLAPMVRSGELPSRLLALKYGADLVWGPETVDRSMIGTTERTNPRTGCIEWSRNSNNQNPDGLEKDSVIFRIDPKRESDRLIYQIGTANPDYAVQAATLIAPYVRGVDVNAGCPKPFSTSGGMGAALLRTPDKLCEILTSLVTKVGIPHEIGISVKIRLLETPELTSTLVNKLCKTGIAGLTIHCRTTPMRPRERAIREQLRMIGDICRSHGVACLMNGDVTSRDQGLALAKEYGVDGAMIATAAEANSSVFRSEEQGGLAHWEEVVKEYMKLAISVENRYRNTKFLLSQLMPGKNPKYQRIQMSKSYSEALAILEITDSELVESAKNVDHVLQLDLPRMTKADMKRLNKQQAKENQAKNKEKKRALEQNHDRGTEDRSPSQERTKKQKAEIAAENAGFEGFGQGAMAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYF8</accession>
    <name>A0A0D1YYF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_00901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240542.1">
        <property type="nucleotide sequence ID" value="XM_016375266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYF8"/>
    <dbReference type="STRING" id="91928.A0A0D1YYF8"/>
    <dbReference type="GeneID" id="27327984"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00901"/>
    <dbReference type="HOGENOM" id="CLU_013985_41_2_1"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW20326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="218" mass="23788" checksum="31CFD88268B40C08" modified="2015-04-29" version="1">MAETTTSTYTIRFATEADVPVILELIRELAEYEHALHEVLATEESLRETLSFPDPKAPDDGSGGTGFTRGYAKTILVVSHGKKTKNDDESATGAAVAATPAAAGTTDDDDDDDDEEEVAGMALYFHNYSTWTSAPGIYLEDLYVRPSHRGKGFGGALLSALARECLRVGCKRLDWSVLKWNEPSIKFYEGESVGAKRMSEWMGMRVDGDGLGRLANRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYY6</accession>
    <name>A0A0D1YYY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240702.1">
        <property type="nucleotide sequence ID" value="XM_016375426.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1YYY6"/>
    <dbReference type="GeneID" id="27328144"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01061"/>
    <dbReference type="HOGENOM" id="CLU_001083_0_0_1"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057283">
        <property type="entry name" value="RGF3_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23582">
        <property type="entry name" value="WHD_RGF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="934"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1163"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1406"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="588"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1251"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1773" mass="196478" checksum="7A30A570F7A6AA4B" modified="2015-04-29" version="1">MASYQNGQSYYPQNNHPASGQNVPYGSQPAYSSRPLERTSSFDAGDDERMFGGGQAQVQPAQGYSAYTASTGTSPHTHRTQSTATFSSSSTPYRTNTQHTALGGYQHQYQQPAVPAHQPYNPAQYQQQQQQHSTYNPQGYATSPSSSYSTSTYQPYVPAAYGEQNINRQNTGYNSYGYYDVNSQVNYPTSASQPPPPPPRPDQPAVYQSFQAYNAYAHDAPQAHAGRHHSSSSTGQSQSGYSPPAPAPPPHNASLLDRRHSRSTSIQDERFSHGTGLSAPYQDAYSLPDVERHASFASRMSNQSVSPQPSIPTPPSRNPSNASPQRTGTNRHPQGRSLPGVPSESDSDNDYFRSTETPNVAQRGSSPAAYDDLMHHLDEAIGGTSLHTRSASAQRYRNSRDGAVEGMFPQQPSPQPRLSPDEVPTHLNGAIASTGDTYINYGAFTDDSDAEAAAGLAAMQALDEQERAEDARRHSGSATLFPSQPRSDGGAARPLSREQSSDSDYTGYDLSSAGGGYLPDLSYGESATSNYAAAASMPQSELYSRLNNRMNSARSSGVSSEGRESQTSGYEMLPPIDTLRSYPAVPNVARVDTGGTGGLTEPSPHPRRLSYEDGDEGVFVDSDVGGRSGDTSPSRDSIPDLFFHPGMSQQRPLPPPPSHSDPGRIPHLMPTGTYTQQSRFSQYAETNRQSYPAAPDAYSNALLSPTTVPRSTSLSSTRSAPRVEYPIRSKTDADRQKALRQQGRPVSDLYDIASPQSAALDLPTLPRKRYNPAKLTADQFKKCSEPWALSSIVTWIRDLAEEEVDLKEHHIAEGIIALFMNKVPTMYVTEAEVLGERVVREMLAANALVREEEWVKFGPGTTSGVLYQLTGSGCYSSKLHLNQTRGRCYSYHCMRTLRKVDLDTLPEEKKSEDWATFYKLKKEDIESHEKKEIERQNVLHEIVTSEDLYISQLDVLRVLYRDRLSTAQPPIVPSKKLPNFLIEVFGGVDKVKKVNQDYLLGQLKYRQTEQGPWIVGFSDIFREWIRKARPVYVEYASNFPRADYLMRREAERNFHFKNFLDQARDDKRSNRLGWDNYLKAPITRLQRYSLLLSTVQKNMLKESEEKNNLAYALDEIRAATYECDAKFAEMTKKMELIEMQTKLRLRPPMEKEVELNLDHLGREIIFRGELQRAGGKGFQWVDTHAILFDHYLVLAKPLYRDRKEGYYDVSKVPIPMDLLVLESATDPAVVKSSVKGIGAVTTTVVPRGATAADTRLNRAQSSSSGGPGTLAHQTTSLSIGSGSASQSMVPITTLDSASSKEEKIMYPFRIKHLGKTETYTLYAPTAQNRQDWCEAIIQAKTRHAEALFSQNAEPFKLRVLADTAFGYEGISYPGKQIKIRGTPLDRAIQEAEKKFEGQGRPAPVCRAPVNCATVFNQPYGRLMCAVGTDYGVYISEYQNSRGWIRAIQMQRVTQISVLEEFNLFLLISDKVLIAYHLDVVCPPSGLPVSHTDTSSRKAPQKLSGSKDVGFFVSGRMKERTLVFYKKRDGIVSTFKVLEPVLQKSTTSRSRFLPSASRRGQTEFFREYDEFYIPAECYSLNLFQSSLAISTARGVEVLTLEKKQTWSVPNLRSEQPETQAHLSSIASRIKDLKPLGMFRLGEAEFLVTFEECAVYVNKHGDISRGVVMEFVGRAKSACLYAQYLILVDDDFVEIRDAQNGRLKQVIVGKDIKLLDDGGGGGGGAQTQAALGGGINGLGLKNFGTAPRMPKLVLQHPEHEKSHVLVELLLTTETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0Q6</accession>
    <name>A0A0D1Z0Q6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241417.1">
        <property type="nucleotide sequence ID" value="XM_016376141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0Q6"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0Q6"/>
    <dbReference type="GeneID" id="27328864"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01781"/>
    <dbReference type="HOGENOM" id="CLU_034979_0_0_1"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237383" description="N-acetylglucosaminylphosphatidylinositol deacetylase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW21201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="366" mass="39873" checksum="8F032823E83B20CB" modified="2015-04-29" version="1">MNGTTILTLSLVPVLFFALWHITAASVPPIPQSMRNKRIILLIAHPDDESMFFNPTLQALTHPSLQNHLKILCMSTGNADGIGDKRRLELEKAAVQLGLRRREDVYVLDDERFQDGMDQVWKPEDIVRVLASAFAPHLNTTPSSQSPAAVASSTSTSTPSKDKDKDKDKRKSKAPSSKTTKQPSSTSSVSTSNPSAPAGPLASIDVLITFDDHGISNHPNHIALFHGAKLFLERIMHGHSGYACPVSLYTLPTVNIVRKYSFILDAVPTMLSGIYGAVFSNISGMVSRSTSGRGSALGTASRGSGAAHRDNPGLLVFVNDIPRYWRARAAMTQGHASQMVWFRWGWIGLGRYMVVNDLKAEKIVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAI0</accession>
    <name>A0A0D1ZAI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230208.1">
        <property type="nucleotide sequence ID" value="XM_016386076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAI0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAI0"/>
    <dbReference type="GeneID" id="27338851"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11768"/>
    <dbReference type="HOGENOM" id="CLU_024588_2_0_1"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF5">
        <property type="entry name" value="ALLANTOATE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="286"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW09992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="518" mass="56321" checksum="AD1418A907E987D0" modified="2015-04-29" version="1">MSRVLWSPVWTFRCVGPKPSARTRATTHSLTRGFTTTPTLLLSTTELWQLNKFNLTVDSDRLWDTIHSTARWTAPKAIPNDDIRTAGLARLTLSEEDKQARDWFVETTKSLGCQVHVDQIGNIFAIRPGLKSTKAPATFAGSHLDSQPSGGRFDGVLGVSAGIEMLRTLNDNHIETEGPVGVVNWTNEEGAKYPISMMGSGVWAGQISLEDAWQVKSVTAGPSTSGTTSPPTVKEELEQIGYLGSVPAHFGEGIPIGAHFELHIEQGPRLEKAKQKIGVVQGVQAYKWFTLTVTGREAHAGTTEMASRADAMHAAAQLMLKVHQIAKHGCSDGKGLATFGRLSCMPGSVNTIAGYVEMSLDMRHPTDEGLAEMEENLYRVCKTMNTIQKNGEPGEDATSNSGGPRVTVKQDFASHAIMFDERAIDCVEQSAANVLAGEEAMGGHEQKVQKMMSGAGHDSVRTNLHCPTAMIFVPSKGGISHNPVEWTEKEDCAIGANVLMQSVLRMDKFRNERGDFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHJ2</accession>
    <name>A0A0D1ZHJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4-coumarate-CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232603.1">
        <property type="nucleotide sequence ID" value="XM_016383980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHJ2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZHJ2"/>
    <dbReference type="GeneID" id="27336747"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09664"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="468"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="64162" checksum="E5E1779769759FA6" modified="2015-04-29" version="1">MPIKSNFPDVNLSVTDIFSLLFDRKEKPFPDDQVIFQDGDHLERKYTYAQIKQLSTDFGKGLKSNYGFRKSDVLALYVPNDIDVGPVVWGTLWAGGVVSPANPGYTVQELVYQLKDSGAKLLVTHISALENAKKACKEAAIPESNILLLGKDGDPSRKFKHWSMVRNLEGTSRWRTPKISPKTDLAFLVYSSGTTGRPKGVRLTHHNMTSNVEQVTAAEPHLSHDGSKKVPGIPDAPKGKGDKVLAVLPFFHIYGLNCLVHLPVFQGIHTLVLSRFDLEKWCRLVQDEQVTFSYIVPPIVLLLCKHPVVDKYDLGSLRMTNSGAAPLTRDLVESLWKRKGVRVKQGYGLSETSPTIFMQPWERWMSAVGTTGVMVPNLEAKFCAVPGPGEESDGTKELPRGEIGELYVKGPNVFTGYHNNAAATAECLEDGWFRTGDVGFLDGDGNLTITDRVKELIKYKGFQVPPAELEGYLAAHDKVDDVAVVGVDSAELGTEVPRAYVVRRGGAGAVQPGDAEEIIQWMNNKVANHKKLRGGIKFVDAVPKSVSGKILRRVLKDQAKKEFKEEEEKKMKSKNSGKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJ83</accession>
    <name>A0A0D1ZJ83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233123.1">
        <property type="nucleotide sequence ID" value="XM_016382420.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1ZJ83"/>
    <dbReference type="GeneID" id="27335177"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08094"/>
    <dbReference type="HOGENOM" id="CLU_001029_0_0_1"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="2">
        <location>
            <begin position="89"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="4">
        <location>
            <begin position="676"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="3">
        <location>
            <begin position="1427"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1820" mass="202073" checksum="BEEE55D2D7091567" modified="2015-04-29" version="1">MAPGSLSPVYLPDLGRCLSGDLLLPSWDDLLDALLSHDDTRSSLAVEILSGDRPKKILSQSYPSFPKPSPSSKTAFDTSSAGIKPSPDYLYDVDQLKADALWLSRQVNIDELEAFRLAILEWQYSAESRLQEGYSEAEVASLKSALGAAFVDKHLQGPQSQSEDVFNSEGSRRTRLARRFLQEKVTILRLRKELLDTSLLPEAVGVSSSQLRSLAAELPSAPQDSIADEVETAIIAIRDQLKDLENGRTWDLDESNVLLLRDSSDTSSLETIGVVLEVLLLRVRQSKMTVSSAALVHWLELMSSVGFFSTFTSQVSRQLAAIQQIQSLGSFVSAALFNLASTIASLNETASSSQQRQQSRLSEYLHDIESIHECNEILAKHAILGNIQAGPAILAWAIIVHEIWTLANTIKEARESHHAQRAIDGVSTFDTATGRRSSGSSASTQQSIFEDLLDGISMGNSQEDPSSPLLDATIDQCNVFDYVTHLSASAQDPLSILSAFELQILQELVTVSQSFLGYTPELVSAQLGLLSNTYRDISNKRPYDPAVDFVEDKFLLAGFYDVSAARFPYECLPFLRFSRALAKADIFNDQRIHYVEFRLRNLTTFTQAAVKGVQYKIIREDESDSFVALEKPINMLDLTQNRLLAFSTRDTSSLSVLPADSVGQVISDPDAPVKIIKWEVNYSCLSYIGKLLECRYMKTLQTCLSPHDDQQAVVSEGIGLIADLLSSILQKAAGEEPTEEVRQHCVAILEESSNQLQSAGSIESLVFEILEQELQAFRQRSVATFNCDVLLSCLDFVIVLSKIQPHMVWSGINRTSLLGRHSTSTYILGIVSAVEVPTRTFVFLAKCAELYRSLVELTLRSYRYDSSMSGGVTSVRRHSMLPTTLRTQTSILSTSTEIMFNAFQEISEWLFQSAEQRNHIGSLIMDTFSDITRYAFDVGQGLDSNTSVTNPFVEPAKYLVSSFRDPSFDNAAISSVLRFLVIRHHETFGTTHVDSLEPRLESALSLATILVRFGDIEDAQFTSAELHIFNSMPSLIRLLLTKKLLRKQCLRLMRSILTAIERQKPTSLLGHLGSASCIDLLHLLRHIDQESQSLEERSELWKFLASLVNDTQQWLATVILNGTVPDGPSRIKEESVRTRHFRGKTFLVSAIEELTNIRNLSQAVAIPMLDFVLEAQQNWSWVTEDVASSSGLVSKLSSFVSQSAWSQSDETELAKWNLIAARVTDISNHHLHHAKAAKDVNDVKAFIPLLEWLTSYAVEVSLYKSSLHANLKKNFSAKYTGLSTLDIKRTGVTEQEYGPNFYYDIDYADKLLAVDPHWRGRKVQSAEQSFTAEFRKANTNLSVVDSELKLLASLQRLCVDHCRSFARDRECQKIMARLVRVCLQSNARAYPPESIFDSLFQTRLDLSVALLGELLTAGAKGEDFYQLLQPAWDAVRFRNGSYEQAIINNDLPYWRSTLYTLFMAMQFHVKKKTKATSIPGTSNAIIPIASTNTTFLEITSDIIAKGFESVVGALQDQKLNKNKTSSDENSLVGPRDVTLLLMLAQAILRLPTLPQFVAEMSARIINSGLLSSCLLLYSWSHLLTRPDLDDQPRYADFCVQLLASLSSLPPVAEHMAVEGVLSRLMTSKTTESLQRVPGGLSHVDQRPGGAFLYRVWAAGMLPLCLNLLHGVGGAIAGEISIFLNQFPNQLTRASTSFMLAPQTRTEGTELTLTVASEAATLALISYILSSYRDAGASAAVDPTTVLPLKGYDEHRKAIAEDIRDMIALKADVRRRMTVPADERESSWQDSNEGDKLDEKIVNELKIALTALGREDDDDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZKU1</accession>
    <name>A0A0D1ZKU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233658.1">
        <property type="nucleotide sequence ID" value="XM_016382955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZKU1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZKU1"/>
    <dbReference type="GeneID" id="27335713"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08630"/>
    <dbReference type="HOGENOM" id="CLU_000288_138_11_1"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="254"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="629" mass="70500" checksum="CC7D1E7B3169F69F" modified="2015-04-29" version="1">MKLINTKTFALEDFFAETAPPYAILSHTWTSEELTYQDITCDGGLSRNTKKGYAKLTQTCRLASQDGLEYAWIDTCCIDKSSSAELSESINSMYAWYGNSTTCYVYLEDLHPCDITSGTATDYGPGRDVEGDSDSDSDSDSHSNIHHAANSLQFCRWFRRGWTLQELLAPAQLTFYDSSWTLIGTRDTFSGVISRITSIPRSVLSQTFPVSECSIAIRMSWAAHRTTTRTEDIAYCLLGLFDVNMPLLYGEGMKAFRRLQEEIVRRSNDFTIFAWEKPASLLALRYSGATFTHGPEGLIDRSTTTGLSIFAPRPSCFANTTIIDWLSKEEVSFSVTNAGLLFSGTVDVRVLNSAHYILLVGLQTTSWRSRLATGIYLRKQTPTIYHRDPSVPLAQLSPLECASLPTVSIRNLVVSTAPKQIDSPTFHAFRQSTVHVSRNPTSPKSPGHRFRLVTAIPETLWSYNEHIFLKPEIYSSENGRESAMYPMVLGVRVLWWPRAIDSIKINESDDDEIDAEDHEDDRDSISLCILCDYRTTPPRCKIFLYGAQGALGPMLFDGRHKSDSVDWADVELQVPSIHDLSDEVDIPLDNDQFTTVSASLPPDRVTISGEEVHVYSLRLEAKSRHEKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZMP5</accession>
    <name>A0A0D1ZMP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234303.1">
        <property type="nucleotide sequence ID" value="XM_016381201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZMP5"/>
    <dbReference type="GeneID" id="27333951"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06868"/>
    <dbReference type="HOGENOM" id="CLU_1200384_0_0_1"/>
    <dbReference type="OrthoDB" id="4117659at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="195" mass="21520" checksum="6C66EB7D46F447D3" modified="2015-04-29" version="1">MSARSVPPASPRDGCSSTLGSLDSNSSGPSPPSSPISRTSSKVMAPLPGVARQPAECAAFGRMFSRTNSSSFKSFSFSCASSGHYPPPHYMGLPTHLPHQDHPCPPCQLENVRMKADREAIAQARAEFPHLTGEMLVRDGRPWEEWQTKPTLEAYVDEKRSDERQMWLHVTRKWTQDLKKARVLVAEEDGLGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZN51</accession>
    <name>A0A0D1ZN51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234493.1">
        <property type="nucleotide sequence ID" value="XM_016381391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZN51"/>
    <dbReference type="GeneID" id="27334142"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07059"/>
    <dbReference type="HOGENOM" id="CLU_447020_0_0_1"/>
    <dbReference type="OrthoDB" id="5392633at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252973" evidence="3">
        <location>
            <begin position="17"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="555" mass="59375" checksum="7C22E384FEFC2A2E" modified="2015-04-29" version="1">MLSIFWAVLSIGIVLSILSTQSSSLAAAATGGPLGAPAGNPPGTIPAGSDPSDNGTTSTDNSQEGYQPEVQALDTILAIACVVLTITTYAVLIGPGTRLLSTCKLPLSIIEENLGNLLSRSWPDNSDSTDSTDPPGANSSSDAIRLMYTGEIDGEQQRAARGLKQCEATLDERISTPPMWLTTGSSLTKSIVQLAVWEWVCAWAALSMTISTLAFNGFFNSDKGPDSYPRLVVVAIYAVAFFLHFWYVYRTFQGFFTLVIAGSSWSLLNKASFASVEFAQFKARLNDDPTSPLFRELGKAAASTTYSVCPATLLQDVGVVPVSDKETLTDSQMSEARTVGDWQKRDITSTVESGRSALDGIVANVMTMVGIVITTGFSVWTTRPTSGTVSSQLGSLALLASLTIGAAAMFSSAIDLSVMLDSFRNVLFLKEVMLNGEASGHVQKRASRKKILGFTHKTVTPRPLRIKDLCTFTSVWSLIVFGPAYALLPSISDHERQSAGAQFELTIRVRGKKVVFSTESTNRHNRKPDGSNVGAINVCYQATPSVQAVQVKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPJ4</accession>
    <name>A0A0D1ZPJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234958.1">
        <property type="nucleotide sequence ID" value="XM_016381856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPJ4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZPJ4"/>
    <dbReference type="GeneID" id="27334609"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07526"/>
    <dbReference type="HOGENOM" id="CLU_1578549_0_0_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19294" checksum="EF13A1115E030EB5" modified="2015-04-29" version="1">MSNPWVPHILRPDYTWPRPIAAIITDRTPPTPSVSSPPVRRFWGVIHSLLARFSELYCSWTGVPFSRQIMQLPFGLVLKWTERVRIEEVIAMQMARAAGMPVPKVLCYGEHPGSWRPISILMTRLPGIDLYNSFDLQAWKKIPGLKNFGNVWTRCVHGRAPLASLFVQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQE6</accession>
    <name>A0A0D1ZQE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235203.1">
        <property type="nucleotide sequence ID" value="XM_016382101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQE6"/>
    <dbReference type="GeneID" id="27334857"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07774"/>
    <dbReference type="HOGENOM" id="CLU_039194_0_0_1"/>
    <dbReference type="OrthoDB" id="2884638at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237880" evidence="2">
        <location>
            <begin position="20"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="588" mass="62430" checksum="30A2D79C1AC34118" modified="2015-04-29" version="1">MHALSVFILLLISTAEVRTSPLGWHEHGHGHGHRYGPHHSQRVDKDANYFGFNETHLPAGCHQVCGRPIECELDDGTWLTFSAPQPMHFPSASASATISGSLPPTSAVPTQWTSGELEGSSTPGMVVSTTPEPASSPAPTSEAQDTWAPPQSTTQGPNSAYVSSSTSSAGLPISDTPTSEVSPIDGQTTSTVGESPDTEVSATWPSTATGPPTSASSQTTASTGSVAASSLSQASTSVSSSTVSTGQLPSPSQFKADKGTRWNLQYIGNLSFANPLGELGVRGDNCRTAKIGDKVIWNCGDMMCGDDVLTCGFTMAPGYYGTDSMMHVDTAGKKSLQDFIKPWAGDPQPPEQYIWGEYSSNIAPINSTHGVVYTREYWRNGPGGDKDVGNAVSSVTLGEDRPIATRVGPLLTGTEAAYLGMLAIMRDGDYIYHYSGGGPSNIRISRVPASDDVFDITKYESLKADTENTWIPGVPMLGSMETGATTSNPGGKFACGGAWGSVVYNNYLAKYIMLCGEYMVSTNMHLADTPWGPWGPAYTIASGGNLTGSYGTMMHPEYSPLADGGDRSWYFSIGPNDKFYMYRVDFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQM5</accession>
    <name>A0A0D1ZQM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_07869</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235298.1">
        <property type="nucleotide sequence ID" value="XM_016382196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQM5"/>
    <dbReference type="STRING" id="91928.A0A0D1ZQM5"/>
    <dbReference type="GeneID" id="27334952"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07869"/>
    <dbReference type="HOGENOM" id="CLU_085752_1_2_1"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW15082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="147" mass="14773" checksum="9C0AF4D4D7CEEA7A" modified="2015-04-29" version="1">MGCASAIALTAFGASYGTAKAGIGVMTASVLRPDNMVRSLMPILMAGIVAIYGLVISILISYGISTQPTHLATSFTQLGAGLAVGLSGLASGFSIGICGDAGVRATAQQPRLFVAMMIILIFAEVLGLYGMVVAMLLLGRGAGGTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZS78</accession>
    <name>A0A0D1ZS78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Caspase family p20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016380051.1"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:PV08_05711"/>
    <dbReference type="HOGENOM" id="CLU_031206_0_0_1"/>
    <dbReference type="OrthoDB" id="5422579at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="579" mass="65549" checksum="FB8FF6DFBA3DC75A" modified="2015-04-29" version="1">MNPLSTLDHTNLCPELPNEILLLIIQACPGSTLKNVRLASKTLEQLATPVLWSKVVLIPNLECIRGFMEALERSKVLLHVTKLVYDARFGNFFYRIKTENPMLSFMATPGRDLSIEAVTQGRFQPYEDMAIEVAMLGKALRLLPNLRALRVREHEDSEEPGPFTSLASLKIPYFYQKMCKKYKVSLEAVKFSSMAGTPGRSYTKGILTAAYSSNIRLHSLKAMNVDARGMFGAMAIRPTGANHQLRLLRDVLQDLQELELGFRNDTLLPTANHIEAISFLLRSAKKLKRLKLRMTDCSLTRCQYTDDDLVSDLAALLETHTAGWTHRPLAPRLETLTLDACICHDQDLLHFLKLHGATLRHLNLSNITLLGGADRRECWVKVIKRFKTDLKLTSVSFSGWFTNGGRQQWFVATDNVDPNRLKPRVEKYVVDKRVQECPLDHVAIKPHLSDVEKPANGEEFEGDLTWTMVYANPLADNVDWQPTEPSFGGSSLNTSDPLSVSSPEDDLLVTDDATDNLNWSEDWDVEHTIHQEDPVILCTKEPYEKHSKSHPFKTIITKKHTVSHSAYTLKKKTTWLFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZVD9</accession>
    <name>A0A0D1ZVD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="27330963"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03880"/>
    <dbReference type="HOGENOM" id="CLU_537514_0_0_1"/>
    <dbReference type="OrthoDB" id="10419140at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="315"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="532" mass="59390" checksum="1535A0FE5CAF02EF" modified="2015-04-29" version="1">MLHLLSAAVQPFKRLPEAIKYPLVRVGTATISIILKAAKPTDDDKNVEKVSTPCLRLPYIKTVSGSLTAELSHFLLSEGRQPQVVKYDCTVKEVRPPIKALTESKTPLEPTTPMTHRQAPWQQHRTLFPCEVIGSTRNNSAQSQTYTAAAEPIRQNTTSAFGVPPPAVVATVPGHLQRVDIEDDSQYDSQSETGTTVHYNIDEHGRSTSYDSIDVNNTSTSVHLPYASSHLPRVHRTRTRTGAVRGSAPKAHLATSHRGFESTSSGDTDGVERVFSSSNTESTSSSTTPLDGNPFAFPQPDPDLEPFPDFYQCQLAVKEQEVEGLREELDQVTAAAQAVIATVQREKSRLEQETHNARLALQTMSMQFQEVDGQCQALERENMELRRYVQAVDQRRLESEDARRNMAIHIQTLENITRALEDGKTALRSRNSYLEAINNELQGRVNLSGASQQLNAALLAQMTEEKNVDVAELRGQVTSLTEQLDKVNEEKWDYFSEKNDAEDERDSERAAKEEAQRELREVRDELRSLQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYP8</accession>
    <name>A0A0D1ZYP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inner membrane assembly complex subunit 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04987</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238008.1">
        <property type="nucleotide sequence ID" value="XM_016379331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYP8"/>
    <dbReference type="GeneID" id="27332070"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04987"/>
    <dbReference type="HOGENOM" id="CLU_137473_1_0_1"/>
    <dbReference type="OrthoDB" id="4119406at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13148" checksum="7987351C62EBA04D" modified="2015-04-29" version="1">MRAFTISRAVRSSVARQQGALQTRYLSTTRSFRQTPTQSSSEGPPEKPINFYGTHGRAFFKAITLAFLTYQIAYWAWLTLETEEIKDQKTREIKSLEQEVRSLDDNRKSQRPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A067</accession>
    <name>A0A0D2A067_9EURO</name>
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        <recommendedName>
            <fullName evidence="6">Ribosome-associated complex subunit SSZ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238598.1">
        <property type="nucleotide sequence ID" value="XM_016377028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A067"/>
    <dbReference type="STRING" id="91928.A0A0D2A067"/>
    <dbReference type="GeneID" id="27329753"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02670"/>
    <dbReference type="HOGENOM" id="CLU_005965_0_3_1"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10232">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSsz1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000009">
        <property type="entry name" value="Heat shock protein Hsp70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000023">
        <property type="entry name" value="Hsp70 chaperone (BiP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="61862" checksum="B20825DB28808A1E" modified="2015-04-29" version="1">MSDNANGTGASPEHYAIGISFGNSYSSIAHISGEGKVEVIANEEGDRQIPSILSYVGGEEFHGTQAKSQLVRNSKNTIAYFRDFIGKDYKAIDPTPCHASAHPIEADGQISFSVQEKEDGEQSTLSVAEISTRHLRRLQNSASDFTGKSVNAAVVAVPSDTSEEQKAALTKAAAAINVEILQFIPEPVAALLAYDSRSFDSAATDKNVVVADFGGNRSDVAVIASRGGMYSILATAHDYELGGSQLDQVLVDHFAKEFEKKHKSDPRKNERSLAKLKLESEAVKKTLSQSTSATFSVESLADGVDFRSTVNRSRYEILALKTFGRFTRLIEEAIKKADLDVLDIDEVVLSGGTSNTPKIAKNIEAFFPESTQVLAPTTSTTALNPSELSARGAALQASLIQEFDKEDIDQSTHEMVTVTPHLTAAIGYQVTGQPASSFSVIIPPDTAVPARRTKVIEGLEGDVLLRISEGDREIKVTQAEAQPKPETNGAKDDDDDDDSDDDDEDDEPEEIREKVWTPKKALAEFVFKGLKKGSKIEVMVNVDAELALSITARPVGGKGGVRGEVKAPQVTSNGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A175</accession>
    <name>A0A0D2A175_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238943.1">
        <property type="nucleotide sequence ID" value="XM_016377373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A175"/>
    <dbReference type="STRING" id="91928.A0A0D2A175"/>
    <dbReference type="GeneID" id="27330099"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03016"/>
    <dbReference type="HOGENOM" id="CLU_048918_0_0_1"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="384" mass="41503" checksum="83730B031623DFA0" modified="2015-04-29" version="1">MFGIIPDLISSVTTFLLPAYLSYKALRTNDPAQTHPWLIYFTILNLTLLFESWTIFIIGWIPFYSWFRLFFLLYLVLPQTQGAKILYLDYLEPYIVGHETRIDQFIGEAHERLQQLGLGYLSVLIEFIRDKVLGQKSPQGDHVPLQQGGGAAAAGYAGYASYAQDLLSRFAMPGARASQPNPPGTSSASVYSMMSTFAGAAFAAGSASSPRSAAQEAASIPGSLFDDIPGSSSAEKQTFVSAQRERLSNMLKALDKEQQSLDLAYGQRPPSSGGLKTKSRSEVSFENVDYDEVTPQQHTPPRPVTEGRRSTSGNWLPAGVGGWFGGGGGGGGGGGDATSSPSDNHGHGGHDERSERERMTSRGWSAARDITEEITRGMSSGVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A2U0</accession>
    <name>A0A0D2A2U0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239468.1">
        <property type="nucleotide sequence ID" value="XM_016377898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A2U0"/>
    <dbReference type="GeneID" id="27330629"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03546"/>
    <dbReference type="HOGENOM" id="CLU_108547_0_0_1"/>
    <dbReference type="OrthoDB" id="5376498at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="180" mass="19602" checksum="03BBAFD5D297FF00" modified="2015-04-29" version="1">MSPSAGDPLAEMPTPEMITLLFKCHKSTTVLSVLPETPFSEIKNLLLAALRSRNVTTLPNTETPLPEDPEQLELGVLVDRKDASKGWVPLLIKEQEFRGAKGLKKKVGGETSVLNESPLGAGLNDGTWIAYRVKAQLKKSEDVDMAEADGASDLDLTEDPGWDVVIPSFDDDDVNDEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A451</accession>
    <name>A0A0D2A451_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239843.1">
        <property type="nucleotide sequence ID" value="XM_016374567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A451"/>
    <dbReference type="GeneID" id="27327283"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00200"/>
    <dbReference type="HOGENOM" id="CLU_032830_0_0_1"/>
    <dbReference type="OrthoDB" id="4118773at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="613" mass="67864" checksum="A7C659227B49AE90" modified="2015-04-29" version="1">MISDRKATVGCAVDLLRAHQLRRENAHLHRQTQAYHDELICTRAEVKELKIIVRGYQADRASSQSLRKLYEARSDEQAAQIRCLRGDLEMLKAETAKHEGEVARYCADTVPERRMLEERLSRIETLFQHAAEASKSHFQTVDARLEGLETGLQSKADAALVEHIHLLTGPIQPPDASLDSVSRVNNSVEVANPLLQEHTGIQVHDSQRTYLPERSANPALNPHHDAATKPAVQSSIPSDLDLDENVNTVSYAGHRILSVDDNDSLSFLSECRAPANELTRANNLTQEKFESWEHYYSRAHSLVQALPATFEEMVVRRFADGLFKTVQRKQCRQWLELKGWTWENVDSFGDISSQIPEAPSSTLAPSAEISARYSKKMGPLLEKKRSTAKRASNAPGRVPTGNNDTRMMPLRRSQRLIEKGNRTAMEAAEKPAKSESQVLGDSYRKNMSISSSQKRKALKEKASGPKQGRGHESTKTGRASGGKDTGHAKAIAGHNPAVTRAQGIDDGMEEAQSPAGCKENERVGQRSCQQEPTKGNSKQPRGGISCVPRLVPQKRALTGAASESSGDEGYLYEQRIKHNNAQEMPVTKHRRVAHRLPLPPPPEIPILSTSSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4T4</accession>
    <name>A0A0D2A4T4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240053.1">
        <property type="nucleotide sequence ID" value="XM_016374777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4T4"/>
    <dbReference type="STRING" id="91928.A0A0D2A4T4"/>
    <dbReference type="GeneID" id="27327495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00412"/>
    <dbReference type="HOGENOM" id="CLU_010348_2_1_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="47"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="307"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="354"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="452"/>
            <end position="454"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="544" mass="62673" checksum="FA81E42AD218300A" modified="2015-04-29" version="1">MSKRNAPDHPESKHPTTKRAKEIDAHTPYEELCSLLENQESPKETKRVLHWFRSKDLRIHDNNALHAASTLAEEAKAPLICAYINCPAEFRWHGTSPARTDFICENLRLMQSELKELNIPLVFLEAGERDELVSTILNFIRENDVSHVFANYEYEIDELRRDIKVLKAGPYENDSSKVFQISFHHDQTVVEPGTMLTGNGTPMKGFTPYHRAWLAEVKANPSLLDTVPPPSKKKFNGGVSEKLKSLFDSKPPTSPDEKRFKDESERKRIRTLWPAGHNAAIDRLNHFLFDKIEDYAATRSNPAKDSTSRLSAYFAAGVLSIRETLSAVRKAAKGSADFSQSGPGGYGIASWVRELVFRELYRQTTLTTPHTAMNLPQNLKFDFVHWEDDEEGYDRWEQGTLGVPFVDAGMRQIKHEAYMHNRLRMNVSSYLYCNLLIDYRRGERYFAETLIDWDLNNNTQGWEPSYTVFNPVSQAEKNDPDGEYIRKWVPELKDVKGKAIFDPYHRLSKDEFEKLGYPAPYVDWNETKQRANERFKSDMKDAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A574</accession>
    <name>A0A0D2A574_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016374877.1"/>
    </dbReference>
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    <dbReference type="STRING" id="91928.A0A0D2A574"/>
    <dbReference type="GeneID" id="27327595"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00512"/>
    <dbReference type="HOGENOM" id="CLU_048788_0_0_1"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="232"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="377" mass="43093" checksum="5E1CD83729776453" modified="2015-04-29" version="1">MTSRDERGTKHNAQHTTHNARSIGRSDHQTRWNGSYKERLFTLVVATMSKRTLDAFFSRADSPKRTRTNATSSAILPTAPVAGSIQTTNHSTYPWPVPHLPGRVTEELELQVTAQGKEIKDQPHLDLLYFQPFIPRSIERELFTFLRSELFFYRVKYTIKRFGKETLINTPRFTTVFGIDETSRFFNDGTQIVEASDLSKPVRKDKYKCRPRPIPECLDLLRRVTEANTNTKYNFCLVNYYASGSDSISFHSDDERFLGPDPAIASFTLGAKRDFLMKHKPPKGQEPKPETRDIKIPLASGDMVLMRGPTQSNWLHSIPKRKGGEAEKGRINITLRRAMIPAGTENYYRYNVGEGGVYKWDDSKREMLPWPGSNVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7W8</accession>
    <name>A0A0D2A7W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241098.1">
        <property type="nucleotide sequence ID" value="XM_016375822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A7W8"/>
    <dbReference type="STRING" id="91928.A0A0D2A7W8"/>
    <dbReference type="GeneID" id="27328544"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01461"/>
    <dbReference type="HOGENOM" id="CLU_000315_2_7_1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="438"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="896"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1065" mass="119957" checksum="E8AF8A71898411F7" modified="2015-04-29" version="1">MSPKHKSIPSFNQADPSRSNAQLPYSPARHSEHRALLDPRSIVQPKRSQISSFSPVQPTFHSGADDNVTHPHSSPPTGLNRQHSGPRSLLEAVHGVESRVDHPRKKIKPSPNPGSAEPKKASSYSHHPSSGIIGGYMRPNPEKSAEDTLRSLVDLTNDDEGDADDDIEIVSSRSLDDEEVCYGHFSTIVHAHRIPKPKNISTFHGEKEWPVMKCTLLRTRSKDTVIEVSDPWGVVFGKVNADFAAALAPVLDGLTGVRTQARLINRRKKPNEWPHVECSETLKMVVNVYGRRKDVARVGRHFGQHNFWFRPPMAPEPGIPIVNPHVKRDPLPPTPRKTGQSNILSDTRTLEEATEAVSKLFDSFAEARSALEESSPPSSVITTPLLSHQKQALTFMLRHERARTFGTEESDNSSLWRRMTTKTGATIYREVVSGISVKDEPEQVFGGLLADVMGLGKTLEALSLIASTLDEAMEFSKEKTIRDDQNVLLANTQATLIVCPTSTVKNWEDQIIAHMDPAAVSYYVYHGTNRERNPYKLSKYDIIIATYGVVASEFSGRGAPSVTPLKQLKWFRIILDEAHTIREHKAQQSQAIYSLEAQRRWCLTGTPIQNRLDDLGSLTRFLRLYPYDTPARFNQYIRGPAQAGDPSFLKALRVFVDSFTLRRLRDQIDLPERKDFVDLLDFSPEERQLHDFFKEIAHVQIQELAHMKQKNSGVQHHVLRGIMTLRLICAHGRDLLKEKDLEKLKGISKSEAIDLDHYMPTTISRQTAYESLNLMTEADLDLCRRCERRITEIEFEDEHGIRCYVLPCFDLICAECFASDKGTFDTRPDKEPVTCPYCFKEIAAQYVGFSGSTAQEILAAPDDNIAEDEDETAMHTYHGPHTKTKALLQDIAAMHMDSQAFEAAGEPPLKCVVFSEFTSHLDLIEIALRDNGYSFVRVDGKMSLNNRKKAMDALASDNNVTILLASIKAAGQGLNLTAASRAFIMEPMWNPAAEAQAVDRIYRIGQTRPVLVKRYQMKDSIERKIVELQKRKQQLADVSLNQNHRQLSKKEVREQHMKEILALFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AA16</accession>
    <name>A0A0D2AA16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241808.1">
        <property type="nucleotide sequence ID" value="XM_016376532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AA16"/>
    <dbReference type="STRING" id="91928.A0A0D2AA16"/>
    <dbReference type="GeneID" id="27329255"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02172"/>
    <dbReference type="HOGENOM" id="CLU_024064_0_0_1"/>
    <dbReference type="OrthoDB" id="5311681at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="597" mass="67522" checksum="FFC073B0F9DB86CC" modified="2015-04-29" version="1">MSFRGRHLYTNGPEVQGAFGVDSLPLTTVAHIISYLEDDATSLARLCRTSRVLYYMTLPQLWKHVVLRSHCAVHYRDDVPEGLGSASPFSMGLNALVTRNVAALVSSLVLEGDYKSLDLEEYSRAGRVSESTMILNIAIRAAINQCIQLEKFRWDLNVRIQANVYAGLGKLSRLESLWIRFQTNRLPQPHTEIPALPNLRSFTFTHYDPMCYPDDVSTLFLNSEKLEVLNMHFSPRMREQGEASVVLARFFRKNMNHNKKIRLKHVGVYNLLATSESAECMAAMDARTIESFTALNTFGVDEDELHRSNTLFIDRTWFLPNTKEAHNTKCLRMDQLHKIHAQEIATSPDLERLYLINARYRRDGVNGESSPSSVDASPRTVNGDTNRSSRSTPTYATAPMMSLRDAYLDSICNGCGPKLKHLIFPARWPLHSALTAKLIRSCPNLTQFSAAIPCSDMEVLRMVIPFLTKLWAIRVVAPRTHGEEGEKALGIFNACINQPDSVLEEDIAKSLRQRGPAGGVPDFPSLRYIGMGHKVWEVGSVYEEKVKVRSPAQMNTPEESSDSSYYEETIYHRKLKRITERDVSDVEIWKMDTMDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AA89</accession>
    <name>A0A0D2AA89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241898.1">
        <property type="nucleotide sequence ID" value="XM_016376622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AA89"/>
    <dbReference type="STRING" id="91928.A0A0D2AA89"/>
    <dbReference type="GeneID" id="27329345"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02262"/>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_1"/>
    <dbReference type="OrthoDB" id="4111246at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="412" mass="45557" checksum="A6210E420BD91C60" modified="2015-04-29" version="1">MGELLGQFLEGKRVFVVGGGIAGSSFVTALHRLWNPSLKRPEVIVLEQKSREASLETDPYILSLHGGSQDEGLVTLRQLGLLEAIGAQATHNSGAIRVWSDKWKQLATIEPTPYDNLPSAAIRISRQDLKRILLDEAEKTGAVWKWACSCTSIEQLSNGQVRVTTFDVNTESSSTQDCDLVVAADGADSRIRAILQPGDKLGYAGANQIGGISRLPNGLPRPIHEDYGLQMSSGEGVCCIYTPFDGQTIGWALSQKGTERRLKSGRFTTEEFYALKTEALKTGKMFHEPFKTIIEATDSTTVFIRPAKERKSASPRLSWSKVAFIGDSNHVLNCFEFKGANLALKDGWDLAEQICGNTSMVKAMAEFNRLSLPRAEHLQKWSHERIRFGHSSGVLWTMYKHGMAAQRWTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASK5</accession>
    <name>A0A0D2ASK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_12041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847504">
        <property type="protein sequence ID" value="KIW09698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229914.1">
        <property type="nucleotide sequence ID" value="XM_016386348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASK5"/>
    <dbReference type="GeneID" id="27339124"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12041"/>
    <dbReference type="HOGENOM" id="CLU_005562_3_2_1"/>
    <dbReference type="OrthoDB" id="4117635at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44273" checksum="FA3E4C2FFBAE5C46" modified="2015-04-29" version="1">MAALGARHQLFSLSSGATTAASSINLTTAVLIRQELVVNSLFWILGRFPTSTPLRLRRLAAKVYHLGGVHSGAAIAATLWFGISNVTLFNSLSSTSAKESEISIRTITILLDILLVTTIATAFPAFRTWAHDLFEIIHRFLGWIALVLFWILFGFLAHVQLTDSPQLTVMDVVGASPAFWSLLLATFSIVLPWLRLRKESVRSEPLSDHALQLHFAGERLPLCAAVRLSTRPLLEWHAFATIPSDDGTGYSVIVSNAGDWTAHLLESPPTKLWVRGMPTIGVLHMAPMFNKVVLVATGSGIGPLLSLTAHRHPVCRIIWSTPDPVATYSRSVVEKVREADPDAMIFNTTESGRPDLVRHIYRLYFTSGSEAVFLVSNPRTTRKVVYELESRGLPIFAPIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT57</accession>
    <name>A0A0D2AT57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230119.1">
        <property type="nucleotide sequence ID" value="XM_016385987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT57"/>
    <dbReference type="GeneID" id="27338762"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11679"/>
    <dbReference type="HOGENOM" id="CLU_024888_0_0_1"/>
    <dbReference type="OrthoDB" id="5287717at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="745" mass="82413" checksum="5DAE4321F4527FF9" modified="2015-04-29" version="1">MSKALYSVVSLRGAKQDSEVLSDENSTRYGSNATMHEPSSAFAIDSPDGDRMQVFLLRTVTCICVPILMTGYYAGLWAYWIEGYDNSGPVPWGPPAGLWAYYIWFVVSAVGIGMSKYGLAGIEAALLMDPRWAPGNAMQLMIHCDRTWSGPAGWVQIRSRPSPAWLLLGLISVIPYVALPLSGFTLQLMNGYTTTRSSTAYRANLVGLRPETFLDQNLEDVFTRSFNRWRSSSPSVLYEKSAYYLPAGSRSEADRSWLKAFPNNWPDEANITTFIAPQSSSIVEGEAWGLQTSLNCSVVSSISQFELLSQRNDDGTAPRCPPINFNSSEGLPEYSGLPDLCDFDVYLLSPIANETLLNLNILDSVNFPVGMMELAVKHQKDSDFGFDVPFSNVKPVLLEAALWQNPIEMVQKCAPLEKVVSNDLGTIVRGFKKTFTHTNLTAMLTGQTDMSPKELDAIGVQCRSSYRTGSATVDGRTGTYTKFVDQEADALVSATPVPLATAIPRIFRSEVSAALSLQDMYGEQAFVDTINSLNVEWTADSNMDLNPMAYVASNISWLQNLYKSVDAFYRQPLYCDDEGNVNLTTTTTWQQLQLINSTQLVTSMMRAHKAYALEMSKPTVQARSAFFLGNLTTVPQTLIVSRGDVPAQPVLALLAVWAFCCSVLGVLYGPRRRWSETLDGYSMFRFGTDQPQVRQACRTTRRFTECSGLRELPGLVGDAARQKSFGYITLVDQWQGAASVEKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AV60</accession>
    <name>A0A0D2AV60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230809.1">
        <property type="nucleotide sequence ID" value="XM_016385865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AV60"/>
    <dbReference type="GeneID" id="27338640"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11557"/>
    <dbReference type="HOGENOM" id="CLU_070845_0_0_1"/>
    <dbReference type="OrthoDB" id="4160315at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="300" mass="33048" checksum="E7F0F8C1E6B4D844" modified="2015-04-29" version="1">MQTRPIQVFLLVFTLILAIFLLIAASKYAAWSHVMVPASGSWLPLIFYVATIPLVSLLYAAVHLAALQFNALPAPPLSGRRSVDPSYDANYTASTTTFILAISILHFLAWLAQACLCTGCELAPILAGTQGRVPRWCPQSRFRDSGNPNLADMLGTLATVKDFMQWVMVLFTIALIECARRESRSAEHARRELFRRAGTGVDFGGPRGDAKGSNQVPLTVIGSNISGPRILTPAEIAAQQRQQQEEEDRKKKQAEERRKQAQLPAGPGVPDNKPDNYYGNGMGNGLKRTKTLNYMYDTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVJ2</accession>
    <name>A0A0D2AVJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10047</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230964.1">
        <property type="nucleotide sequence ID" value="XM_016384362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVJ2"/>
    <dbReference type="STRING" id="91928.A0A0D2AVJ2"/>
    <dbReference type="GeneID" id="27337130"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10047"/>
    <dbReference type="HOGENOM" id="CLU_1245380_0_0_1"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="4">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW10748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="222" mass="24312" checksum="622B5D328CC780DC" modified="2015-04-29" version="1">MENKAVWLAGPGKPPRISSAPTPKPGPGDLLVKGVAVQLGEWKIQAGLTSATLTYPTMIGLLLSVIVEKIGSGVSRFAPGDHVASNSTGVLRKDARFGAYQRFALVRQEMTAKISRRSFDEAASLPTAGGGGRILFATGARPEMQFPPGVSGFFKRFIDDYLDPNNKDFVQWVWWDYFEVAFTDGRIKSLPLEVKQGLAQVNEVWDLLRREQPGGKRLILVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVU0</accession>
    <name>A0A0D2AVU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">DNA repair protein REV1</fullName>
            <ecNumber evidence="14">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PV08_10157</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="14"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231074.1">
        <property type="nucleotide sequence ID" value="XM_016384472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVU0"/>
    <dbReference type="STRING" id="91928.A0A0D2AVU0"/>
    <dbReference type="GeneID" id="27337240"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10157"/>
    <dbReference type="HOGENOM" id="CLU_003901_1_1_1"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
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    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
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    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 14" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="61"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="366"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="740"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="854"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="926"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="861"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="946"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KIW10858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1177" mass="129489" checksum="A0D57AEFA8B80896" modified="2015-04-29" version="1">MGSRLEKNSASVRKRIESHTFSDEHGEEYEASKFGGFADYMRRKKIKLQNLDAEIRSHSGDKPPIFRGVVVHVNGYTQPSLSDLHNLVVSYGGGFLQYLDGKTAVTHVVASNLTPKKAVEFARYRIVKPGWVVDSVKAGRLLPWDAYRLVDEGVTQKVLGFENGQMISQTNNNQKDTYRDQSETSWYASQLRRVRDIVTETAQSSNPQSLPEEPDGLPPDRSEAGLPRGSSATVPAVPEARLEAIAGLVDDHSASNARDHADSPLPSPPTFPSHPLAVFDSNAAHKSENRQLTAEEHNAVLLQNPHMAKSSTANPDFINQYYRESRLHHLSTWKAELKAQMQARAQEKYSSRKSKQSRTPGARRYVMHIDFDSFFAAVSLRKHPHLSDKPVVIAHGSGPGSEIASCNYPARKFGIKNGMWMKTALEMCPTVKVLPYDYKAYEEASRHFYDSILAVDGIVQSISIDEALIDVSEQCIKAGGSDGRGVSEGSIYREQEAAQRLGDELRASVKEKTGCDVSVGIGGNILLAKVALRKAKPAGQHLIKPEDVLDFIGELVVTDLPGVAWSIGNKLEDIGIKFVKDIRLCTKERLINALGPKTGEKLWDYSRGIDKQEVGEQVVRKSVSAEINWGIRFINQQQAEDFVQSLSDELSRRLLEQLVKGKQLTMKIMRKAADAGLDPPKNLGHGKCDTFNKSIMLGVATNDASVLGREAVSILRSYNFPPGELRGLGVQMQKLEPLKPAVSGSAGLPDSSQRRLQFKKPPTPSRPAEEPSLHAAFPPVVHSPNAKHVEDPIEEIPTPEKGKLQDNVYSALDDHTNDAAQQRPLNVSGTQFIMPSQIDPTVLAELPSEIRTKLAPKQKSIMDSITRSSRSQTPPVDGHSRSTSPYPNDHESTLPRPSQIDPEALAALPQDLRDEILAQYKAQENGVSLSRAVATSPRKPKALPSSKKTSVTPTKRQKTSTLSGKARLKRVGDASLSTLAQSSFVSIPKATESYSTANQDPVEISESFLNELPEDIRLEILEEQKRSRMKAKSGLNFESARKKTKVTTTVESGVAGQQRLQLAKQAEKPTFTSQKLSSLPELRDAISAWVREFSSAGESPDQDDVNALADYLAKVVTIERDMAKAVAVVNWLGLILEYENFTGEDVHGAWKGALEILKQQVQVAVKERGLAAVVFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVV4</accession>
    <name>A0A0D2AVV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230766.1">
        <property type="nucleotide sequence ID" value="XM_016385822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVV4"/>
    <dbReference type="STRING" id="91928.A0A0D2AVV4"/>
    <dbReference type="GeneID" id="27338597"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11514"/>
    <dbReference type="HOGENOM" id="CLU_031573_1_0_1"/>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="38839" checksum="4D8AB0E98F7E3CDF" modified="2015-04-29" version="1">MAAATAAAEVQALLRFLTKDAKLPLAEAMSKITVLRKEQLNTPEKISRADEATLKSVFTDEKVRKQVHNAAKRVSNPRKRSAQAESSAPKRVKAESSVVDEESSLALPVTAISLEEIESLTIETNRAPLFLAFTIAVLSYTHSEQPLSSRWSLAQAVVSAGAQSKAKYLGLTSGRTAEEDGWAQGQPKVKIMGREVAVMRRHIPVQSGDDADTSPSTAFWGLDLEALRRSNGPLIGAIDGYRQDGPPIHKPSAPRNYLLKSMVVIGSDDAQGEGGKSDKSGKKPSPKSMAGKREEAAAILLKAIDAVCQSWASTLSKEDLDQRAQGWYMLVRPEVDHGQAGWGQRGKVHLKDVLKLKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXK9</accession>
    <name>A0A0D2AXK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_10743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231659.1">
        <property type="nucleotide sequence ID" value="XM_016385057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXK9"/>
    <dbReference type="STRING" id="91928.A0A0D2AXK9"/>
    <dbReference type="GeneID" id="27337826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10743"/>
    <dbReference type="HOGENOM" id="CLU_030352_2_1_1"/>
    <dbReference type="OrthoDB" id="2402916at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018571">
        <property type="entry name" value="Membrane_anchor_Opy2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09463">
        <property type="entry name" value="Opy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane anchor Opy2 N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="441" mass="46328" checksum="D8E41368ACAAD4F9" modified="2015-04-29" version="1">MADAGLSRSHTHNLFRRCVQCPQEPPSCPSCAADETCSLSAQSCNSCASTTCVKIDSIPGQSSPKKSTPIGGIVGGVIGGLILLAVVIYCIYRFRVRKKKRVEIWDPPEKRDQSTLHRAHRQSTRSAHSIASTVLTRASNVIQIAYIPGVTVRSPPESPALLVPPVPALPGGVGNSATSTPALEQHFFMPGDLRDSTWSDADSVDARFSVAPSLARNSVATTIYRSDAIVPPIPAQQAFRAQANVVSVKSGANTPGNSSTPNTRTPKIPQGPSMGSSTSSIVARNVTARPIEVKKTNSGTSVPTLANLAKKTARQSGTPIPGSEKSIPIYSDEKEVVASKSTVTSPITVLMDDPISPITIPRPAFAGDQSTRSSSVSAILPPDALKQSSSNNTINAMIADAISRARDPQAIGVTSPTSRPALVQHDSGPFSDSNEVKENLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXV2</accession>
    <name>A0A0D2AXV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231491.1">
        <property type="nucleotide sequence ID" value="XM_016384889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXV2"/>
    <dbReference type="GeneID" id="27337658"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10575"/>
    <dbReference type="HOGENOM" id="CLU_1288769_0_0_1"/>
    <dbReference type="OrthoDB" id="4113557at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="218" mass="24308" checksum="D218F1523B026756" modified="2015-04-29" version="1">MSVKKVPSPVSIARVIVSPPATTLAQSTAILRELQAFGPVTSFHRSKLTRKHTSRSPDNGLVKQEIEVTFSDPETTQMAVNASPFTVNFTCNVPNPQVEDPFNLRCLKAREVPRSRTMMCRVEPHIMKEFHGQNALSKGFSPNTQTRLHQSLLDMKPPPAIADGLGVLQPGKSDILDTTHLVERPPDLMTMYRQPHKQADQQFQNEDKKTRASTSIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYP4</accession>
    <name>A0A0D2AYP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_10800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231716.1">
        <property type="nucleotide sequence ID" value="XM_016385114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYP4"/>
    <dbReference type="GeneID" id="27337883"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10800"/>
    <dbReference type="HOGENOM" id="CLU_1777471_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="146" mass="16575" checksum="6C5A8261E605807C" modified="2015-04-29" version="1">MAQEQNTQTLLDFLANNGREVGHLRDMTSTYRERQLAFRGILRHAEQEIRDLRPALNGDNHGDALVAIARFHSIEDMASEALTIVDTMLRWLGELVALLAEIHTNPQLAGGFQRTFILAREIKYIHVRLGPYVSASLQVLRQDLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYQ0</accession>
    <name>A0A0D2AYQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231726.1">
        <property type="nucleotide sequence ID" value="XM_016385124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYQ0"/>
    <dbReference type="STRING" id="91928.A0A0D2AYQ0"/>
    <dbReference type="GeneID" id="27337894"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10811"/>
    <dbReference type="HOGENOM" id="CLU_032158_1_1_1"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="48317" checksum="ED200BEFBC070DED" modified="2015-04-29" version="1">MSRRTSMRQLTSHNLSTFRRQPFAEISGSLGDLGTFLPIVIALTGGHQISLTTTLIFTGVYNILTGFLFGIPLPVQPMKAIAAVAILNNLTAGQTAAAGIFVSSCILLFSITGLLSWFTRVIPIPVVKGIQVGAGLSLIISAGSKTLSSLSWTGPSWADNYIWMIVAFLVLFAISLRPRTPYALILFILGIIFAIIRVSANPHHHLPGFRLWHPYVQSPSTSEWKTGILDAGVGQLPLTTLNSIIAVTHLAADLLPDVQTPSVTSVGLSVAAMNLFGCWFGAMPVCHGSGGLAAQYRFGARSGASIIFLGLLKLLVGILFGESLADLLRKFPLALLSVMIIAAGLELASVGESLNTPRARDLYKERARSTSSPDLTDEERRNRWTVMLVTAGLLIAFKNDAIGFIAGMCCHWSYHFPSYIASMRRDRTLSRENNSATHDENQALLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0A9</accession>
    <name>A0A0D2B0A9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_09670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232609.1">
        <property type="nucleotide sequence ID" value="XM_016383986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0A9"/>
    <dbReference type="GeneID" id="27336753"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09670"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="64"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="507" mass="56675" checksum="349A947464A73B30" modified="2015-04-29" version="1">MRFSIDGSDEKANEYDVASGPGNTQAHYDPDLAHPAAAYIDNQAATLPAGVSERKLLTKIDLRVIPVLSVLYLLAFLDRTNVANAAIFGLQKDLGLSATQYSTALTVFFPPYIVFEVPSNILLKRFKPHVWLSGCMFMFGLVTVCQGLVQGYGGLLTTRFFLGLFEAGMFPGSFYLIGMWYKRHEAQKRYTFFFASTTLAGAFGGLLASAIGKMNGMRGYLGWRWVFILEGVLTCVVAFGCFFLIPDFPEDAKWLTEQERMYVKARLQADQGKSAIERRITFKDVVNCFKDYKFILGWLMYFGLIVPAYGYAYFAPTIIKTYGYSPIQTQLHSVPPWAAAFGFSMLVAVFSDRLRHRFLFALFPICISIAGFAILMNVHHDTHTEYAALFLITSGTYSAMPIIVCWFTMNLGGHHRRSVGSAWQIGAGNIGGIIASYSFAAKDAKTFFHKGYSICISFICLSAVSCILYFIACFSQNKSRAKTHDVGLTEYEKTELGDMSPDYRYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0G1</accession>
    <name>A0A0D2B0G1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232649.1">
        <property type="nucleotide sequence ID" value="XM_016384026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0G1"/>
    <dbReference type="STRING" id="91928.A0A0D2B0G1"/>
    <dbReference type="GeneID" id="27336793"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09710"/>
    <dbReference type="HOGENOM" id="CLU_027663_1_1_1"/>
    <dbReference type="OrthoDB" id="5376312at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="484" mass="51992" checksum="A63C07A5626D1A61" modified="2015-04-29" version="1">MTVLPTRSHPKRHDENQLYPRQSEPSGGPDVGGGGGGGGIAGSAVTVGIIVAIVAFITLSILVYSFLRKWRQQGKSPRYIPTQFLKRKWQTWQPGGKYSAVRNRDLSSTNTAYTGSNVAGSESGAGVDRNTSVRSVITLPAYSRTPKDTEQVIGREGERAGMDTVVEFPETADEEETRREDQMESLYQIRLARRREQAERDERRRERREARERGDTARVEELRRESRQRATESAVSLNGGVSVSAATLIAEHQSRGRDRRVSSVAYGSLGEVRHDGTRLRANSNESERGGLLSGAAPMGEAGGRPRLYSDATSMTTISRPQTRNRSISDVSVTTAGSDVDGQPTPGSTIAGDGARGRSSHSDERQSGTTNSSPTANRFTPDESTGSEDIGESRIPPTETDPAPLPPDYEVLEWGDAPSYEAAVARAASNAAARAGEPTRAPSIAPRLPQLNLPSISVSGATEPNTPVSPGVPSAERSPEEARTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0Y8</accession>
    <name>A0A0D2B0Y8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232576.1">
        <property type="nucleotide sequence ID" value="XM_016383953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0Y8"/>
    <dbReference type="GeneID" id="27336720"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09637"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="68"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="550" mass="61246" checksum="34129124E2AE2D6B" modified="2015-04-29" version="1">MALGILEPGVEHVPGTVYVYESEQRHADLLETARHLKRDKTGRVILVPQPSNDPNDPLNWPLWHRDLILGILCFVSCLATTASPLLAADSVTIALIFKRTFQDAALLTAYHLVGVGVAGWLFVASARVWGKRHLFLLGALLMVATSAWGGSTHTNHNYASLLWSRVFQGVALAPFEALVNACVGDLYFVHERGVRMAITNTCLFGGAFLTPVFVGMISAHIGWEWSFYLLAIFMALGFVLLFFFVPETAYRRAHALDLDLLAEDSSTETLPPSRNATAPESGEKPLHSMSVTESPGRKVSYVQTLMPFNGRKTDESFFRLLIRPFPLFFHPAVAWACLIQGVIIGWTVMVGVILSLIFLGPPLFFNEERAGKMYTGAFVGSMIGLLLAGLYSELVTNFMIRLNKGKYEPEFRILLVVPTLVFSAIGLYGFGITANEVAKYGWIVPVVFLAFIIISMVMGAIASAQYLLDAHRELAVEAFTDLLIFKNIFSFVLAYNAYNWVFAIRINNLFIIFASIEVALCLLSVPMYVFGKKNRDFFHRHDILKLTKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B342</accession>
    <name>A0A0D2B342_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233564.1">
        <property type="nucleotide sequence ID" value="XM_016382861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B342"/>
    <dbReference type="STRING" id="91928.A0A0D2B342"/>
    <dbReference type="GeneID" id="27335619"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08536"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_3_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="503" mass="53979" checksum="49745BB665932859" modified="2015-04-29" version="1">MDKLRQSPILLKDIPYTFKDISLLDDRAFAGGAWQKSSSGRTFPVEDPSDQQILARVADCDVDDYENAIHEAHAAFVSWKATTPNARGKSLRRWANEIQASCDDLAALCTLELGKPFKESLSAVTYAINCVNWFANLAEEGCGGETVPNSGGQSKTRIFTIRQPVGVVGAITPWNSPFSGVLKKIAPAIAVGCTVVHKPAPETALCAIALAKTSERAGIPAGVYNMLTSSARAAAEVGSLFSSHTMVRHVTFTGSTGVGRYLAERCGANLKKVTMELGGNAPFIVFDDADLDLAVRGLLACKFTSSGQVCIFANRVLVHTNVHDMFLEKLQHSIQQNIRQGSPWDQHTTLGPLYARQGAEKVDRLVNDAILKGAECLTSGNYEQGSTYYPAKLLIKVTGAMDISKEEIFGPVVAISAFQTEAEAIEIANSANTGLAGYVYTENISRLFRIAEALQVGMVGARTGTISAIEQPFGGIKDSGLGREGSRHALEEYTDLKAITLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3Q0</accession>
    <name>A0A0D2B3Q0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233521.1">
        <property type="nucleotide sequence ID" value="XM_016382818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3Q0"/>
    <dbReference type="STRING" id="91928.A0A0D2B3Q0"/>
    <dbReference type="GeneID" id="27335576"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08493"/>
    <dbReference type="HOGENOM" id="CLU_021588_1_0_1"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF2">
        <property type="entry name" value="CAIB_BAIF FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="572" mass="63947" checksum="F743F8C69E6AB423" modified="2015-04-29" version="1">MASDSLVSEYSIVDQSYQLLHSGILNNPVILKLLPSKAAEYAKRIKFEGCHKPAFPINWRFAESIAVLKATEGIMMNALLEQKYGVEPEDVVVNIDHAQLFLISCLLTTIKTIDHVSVSTEGFATTSIFPSCDIYRNSASAYRSCAGNMYHTKDGRFYHVHSNLNPDKLQDALGLPHDSEGDDDNYDVAHKLYQERAIQYTAAELDDLCNEVIKISGTVAWSVEEYLASEHAHANADRQLWNVQDVPNPNQAPCWWSSSDETSVSRPLSGLKVVDFSRIIAAPTLTRGLAEYGASIMRITSSHLPDMGFLHPDMAWGKWNTDLDLRQPADLEKAKQLILEADVVVYGYRPEVLSKYGLGCDDVLELCHNRERGLIVARLDCYGWVGPWAHRSGWQQISDACCGVSLDFGRAMHGTDEPVTPIFPNSDHCAGLAGHLGVISALLKRAQNGGSYIVDCSINAYSHWLVQSVGTYPQEVWDKVWSQHGRPKFRHYQPMQYLFPQGVKMLKANMPHLFNPDYFEDRDAKAMGCKVNCVKPALRFPSGKVKLRFQVGARTNGIDQPKWPSDLLTEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3R8</accession>
    <name>A0A0D2B3R8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233724.1">
        <property type="nucleotide sequence ID" value="XM_016383021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3R8"/>
    <dbReference type="STRING" id="91928.A0A0D2B3R8"/>
    <dbReference type="GeneID" id="27335779"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08696"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="55672" checksum="40612EBFB5104855" modified="2015-04-29" version="1">MISVSNIALLLLVYTLTKYFLGWYRLKHIPGPFWAGVTKFWQLKHTWNGTLYLESAEACFKYGTLGPLIRVAPDELITSDPELLRRMLNVRSPYRRSDWYEAIRVDPEHDNVLSERDDERHAMLRSKMSNGYAGKEIPNLEGAIDDVIGKLVNLIEKKYLSTKGQYRPMDFGRLAQYLTMDVIGEIAFGKAFGFLEDDEDKFSYISTTESTIPLIILTGAFPWLAKIAQSSMMKAFMPKDTDAYGLGKIMGQQVVQERFMTDATDHMDMLGSFIRHGLSQKDAESETMIQILAGSDTTASAIRATMLHLLTNPPVLNKLLAEIQSSKLSDPIKDSEARMMPYLQAVIKEGLRIHPPVTGLMLKDVPPGGDTVLGYYIPPGTKLGYCAFGLFSDPKIWGEDSKVFRPERWLEGTAEEIRQKENDLDLVFGHGRWQCLGKDVAKVELNKAFVQLLRNFEMAIVDPERPWSSFNAGVFIVHDMWIRVTKRNPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4L6</accession>
    <name>A0A0D2B4L6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233851.1">
        <property type="nucleotide sequence ID" value="XM_016383148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4L6"/>
    <dbReference type="STRING" id="91928.A0A0D2B4L6"/>
    <dbReference type="GeneID" id="27335909"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08826"/>
    <dbReference type="HOGENOM" id="CLU_024572_2_0_1"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015237">
        <property type="entry name" value="Alpha-amylase_C_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006968">
        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09154">
        <property type="entry name" value="Alpha-amy_C_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="31"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW13635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="553" mass="62673" checksum="909D73B70FCF6D75" modified="2015-04-29" version="1">MQRLNHLARSLSGGLVRHDTPEDSFPLAENKTIFQAFEWYLPGPQDDSDNNPSHYTLLTSLLPHLATLGITHLWLPPGCKATSVHDNGYGIYDLYDLGEFDAKRNGQPSRTKWGSKDELQVFCQAAKDHRISVLWDAVLNHKAAADDKEVSHAVKVDPKADRTKTTTRPFEIESWTVFTFPARGSKYSDMKWNWKHFTAVDYDSRKKDHGVFMFVGEGKKGEWATDVSKELGNYDYLMFADIDHSHPAVRSDIKNWATWISSTLQLGGMRLDAIKHYSLSFLHELLQHLDTTTPRGTDLFFVGEYWDANSEALQKIVEKFQGRLNLFDVQLVYNFSDISKGRNLDLRTVLDGSLVERTPRHAVTFVQNHDTQELQSLAAPVEEWFIPMAYAIILLRQGGTPCVFWGDVFGIHGPRPRLPACGGKLTRLVVARKLYAYGQERDYLDSDDCIGWTRSGHKTKSNGAGLAVLMTNSWDRKSKRMFVGQKHAGETWRDILGWELDVVIDRTGFGKFSVGHRSIGVWTHEKAPGLEGLRKFTFPRQSHGVPPITTLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6X5</accession>
    <name>A0A0D2B6X5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="5" type="ORF">PV08_07457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234889.1">
        <property type="nucleotide sequence ID" value="XM_016381787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6X5"/>
    <dbReference type="STRING" id="91928.A0A0D2B6X5"/>
    <dbReference type="GeneID" id="27334540"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07457"/>
    <dbReference type="HOGENOM" id="CLU_037990_0_1_1"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000133">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW14673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="303" mass="33242" checksum="AC7C27DD05C7DDFF" modified="2015-04-29" version="1">MLRSITRRLTSCRSHSSVSAGTPIRLFSTAQLRSQQLPGEDGQTTHFGFETIAEAQKEARVGAVFSSVASSYDTMNDLMSLGIHRLWKDYFVRSLNPGSRTDDKGWNILDVAGGTGDIAFRMLDHATNVNLDLNTKVTIADINPDMLAEGQKRALETPYGKSGRLSFMQGNAESMPSIQSNSIDLYTVAFGIRNFTNKDAALREAFRVLKPGGVFACLEFSHVNSSVFNAVYKRWSFGAIPLIGQLVAGDRDSYQYLVESIERFPTQEEFKTMIQDAGFLTSGGGYENLTGGIASIHRGIKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7C3</accession>
    <name>A0A0D2B7C3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_07334</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 13">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234766.1">
        <property type="nucleotide sequence ID" value="XM_016381664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7C3"/>
    <dbReference type="STRING" id="91928.A0A0D2B7C3"/>
    <dbReference type="GeneID" id="27334417"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07334"/>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_1"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000015">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000024">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="14">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="12">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW14550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="428" mass="45101" checksum="F60DADBAFDC371BD" modified="2015-04-29" version="1">MRRVVVTGLGAVTPLGVGVRQTWKRLINGDCGIVSTRHLGDEFKTIPSQVAGLVPVHSSLGGSWHAKDHVTPTELRQTARFAQYGLAASAEALKDAGFEAGKGLDPEMTGVCLGSGIGNLEELYDTTVAYAQEKNYRRIHPLFVPRLLINLGAGHISMRYGLQGPNHAVTTACTTGAHSLGDASRFIKAGEADVMIAGGAEACIHPLAIGGFARSRSLATVFNDEPQKSSRPFDKDRAGFVIGEGAACVVLEELEHAKARGARIYAELVGYGNSADAHHLTAPREDGRGPLLAMKKALRQAQIPPSAVDYINAHATSTPLGDAAENKAIETLMLGEHGRYSSAEITLSSTKGAIGHLLGAAGAVEALFTILTVQENVIPPTINLASPEKGFNCNYVANVAQQANVQVALTNSFGFGGTNATLCFKKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7E0</accession>
    <name>A0A0D2B7E0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleoporin Nup82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_07628</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235059.1">
        <property type="nucleotide sequence ID" value="XM_016381957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7E0"/>
    <dbReference type="STRING" id="91928.A0A0D2B7E0"/>
    <dbReference type="GeneID" id="27334711"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07628"/>
    <dbReference type="HOGENOM" id="CLU_009483_0_0_1"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="845"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="692"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="851"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="868"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="925" mass="101662" checksum="EA86347F0A897D24" modified="2015-04-29" version="1">MPKVIGHTPPWLSRPSAGAKVFSDPAPQSPASPSKRSSYLGSPASTEYQGPRRLVASRGTEIFTVVGNKIRWADLSLIKDEWEENAHSGHSRFGLSRSVESATEQVYRTLDVSIYYQIRQIVTSPSGIFLAIATEHTVHIAALPPSSRLRDQDRSPIKLKTFQLGPTIHVIPESPLASVLWHPLASSTASTDCIVTVTAEAAVRVWELDRSNKWSFERPALAIDLRKLADGVSCDQDFEPSGFGKTKGFSVDDFDMEVSAACFGGRGKDDEDAWASMTLWTAMRNGDIYALCPLLPTKWKPTSTTIPSLSTNAVSRMASIAGEHADMDERRAADQQYEWVQEIDSEEPLLLDSTDSLGEFEVRLRPQNPSAIPRLQGPFAIQPEDDASDIEISDIYVCPATIDEGDLMSGEDDDDFDQFASHGVPFTTVCVATTDNEVWFAIDLDGVSGQWLPKKGKSTFGVPTPDTKELTLIDTFALDAEADSASNWPMLTGDIVSSYSLFLTTSKHIYSLSLNDWTTHLAAEMTGTGNVDPGMRTRLETACETQVCITDKVISTNDATETLSAPTIVDDMSLGYLLLTATTSSAYSVFFDQAHLRASTLALSSPELTTTSSSRQLARISPSEENDVETLPTRSPYVPAKIFYANHLYPIEQMKQRLPPTLKRAVMDKPMRLSPAMLEIMTVTHRTVSAQSVELEKAAAELFRRCERLREELLSQVQQMSELAQRLQHLRSSEEVDEDGTVTAKKSVTTRIQDAQNRQAKLLARYEALRRKVGRVGSAKRELSSKEKTWIEEIDALSRNVGVGVREDGDEEQAGDRLDKRFDMVKQFSRELLEEGKRVIVEQAQAGAASSEPSQQPPMSASVSTIRSGTSASGAGAGSSTSSTFGVSSRLQKEKIADVMAMVEREGAVIDAVMKRLDRLNVEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7Y8</accession>
    <name>A0A0D2B7Y8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_07580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235011.1">
        <property type="nucleotide sequence ID" value="XM_016381909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7Y8"/>
    <dbReference type="STRING" id="91928.A0A0D2B7Y8"/>
    <dbReference type="GeneID" id="27334663"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07580"/>
    <dbReference type="HOGENOM" id="CLU_060603_0_0_1"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sde2 ubiquitin" evidence="10">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="11">
        <location>
            <begin position="97"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW14795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="335" mass="36445" checksum="AD381FE71F1D2AAF" modified="2015-04-29" version="1">MQPVVNVLLDTFPGLALPPTLCIPLPASSSTGELLATIVNLLPSRLPPTRLLLTSTTSRPIYASDTTTLADIAQHQTCRRDVDSTILPLRLSAPLVGGKGGFGSQLRAAGGRMSSRKKRQNAELATGSARNLDGRRLRTITEAKNLATYLATKPDMDKKEKEERRKKWEQVIELAEQREADMRAGKGPDGRRKGLSDEWVEEKEEIGENVRNAVKMAMLAAQEKSTSATSSEEADESSGSGGSASGSEADSDVDDVMELDQDEMARLRVEAEGGDADALWVLQHRLKIPSRLLPKARQPVRRFAGFDDEDDISGSDEEESPDEEVAGKGKQRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B843</accession>
    <name>A0A0D2B843_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3',5'-cyclic-nucleotide phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235259.1">
        <property type="nucleotide sequence ID" value="XM_016382157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B843"/>
    <dbReference type="STRING" id="91928.A0A0D2B843"/>
    <dbReference type="GeneID" id="27334913"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07830"/>
    <dbReference type="HOGENOM" id="CLU_016658_1_0_1"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="67717" checksum="A03C7C19F0A2DA9E" modified="2015-04-29" version="1">MREHDARREAPKQLRELGEKNEASFHVIVLGSSGGPLEHNVTGLLIRAPQTKWRKSSMIAVDAGSHLANIIRILERQMPPSSEHLPPADYSRTLEAGPFAGIPFPNISAKANGLHIFREILHAFLITHPHLDHLSAMAINTPALEYGREAKAIVALPSTIEAIKNHIFNDWLWPNLSDEGNGVGFVTYRRLIEGGNPRLGSGDSRGYVNVCDGLATKCWGISHGKCQRRRVSLSGHQHNDSFGYTGDYTFPSRRMSRISDASHDYFAAVAQQQQQSHLPSQPYIHGTSAGPMTPGGSGVPPTPGPDPNYLFEPVSSSAFFIRNDATGNEILIFGDVEPDSVSISPRNHVVWEDAAGKIVSSSLKAIFIECSYDDSVRNEDLYGHLCPRHLIAELTFLAKSVINKRKQHADQMTGIDQRTQSTAPVVPDMTMRQPPSPTDLRRKRKRAVTSLNGESTLVPTLEIEEPTNFDGTASGLPSTGPSTANTGYVGTRATSHTHLHQHSRRKTSREVNSHSSTASVPLTPGGRAKPASIQASPRSPTTVYSSSASQGHGHGGQSSSGPLPREKLGGPLKGITVHVIHVKDTLMDGPSPGDVILGQLRAQGEEIELGVEFNVTHCEDSIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B866</accession>
    <name>A0A0D2B866_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235299.1">
        <property type="nucleotide sequence ID" value="XM_016382197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B866"/>
    <dbReference type="GeneID" id="27334953"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07870"/>
    <dbReference type="HOGENOM" id="CLU_196188_0_0_1"/>
    <dbReference type="OrthoDB" id="2122015at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007008">
        <property type="term" value="P:outer mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035195">
        <property type="entry name" value="Emr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17237">
        <property type="entry name" value="Emr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="54" mass="6267" checksum="1D0919487917E1C6" modified="2015-04-29" version="1">MALPNLRRLFVEARTEAEENEYSRNAFYNLVLFISSVAVFSLVAQRMSNNKSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8G0</accession>
    <name>A0A0D2B8G0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235439.1">
        <property type="nucleotide sequence ID" value="XM_016379612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8G0"/>
    <dbReference type="STRING" id="91928.A0A0D2B8G0"/>
    <dbReference type="GeneID" id="27332351"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05268"/>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF1">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="58547" checksum="A6E3FC49B47A366B" modified="2015-04-29" version="1">MDNVYAMKDGGKYASEVHHSRHSSDGMQNVEKSVDRDEQEMARLGKRQELRRNFGFMSMLGFSCTLMITWEGLLTVFVYGLTDGGPAGLVYGYLFCWLGYFTVVASLAEMVSMAPTAGGQYHWTFLFAPKSCRNFLSFVTGWQSVLSWQACLASAAYLGGTIIQGLLVLNYPSYDFKRWHGTLLLFSVILLALLFNTYLAKQLPKIEGAVLIVHIVGFFGVLITLVYLAPHGSAHDVFIKYLNSGGYNKGTSFFVGLITTVFAFVGADGAIHMSEEIINASTVVPNSLVASIGLNGVMGFAMLIAILFCIGDIDSALTTPTGFPFIEIFRQAVNTNGGATAMSAIVLSLMIFATIAVLAAASRMMWAFSRDNGLPGSHYLSRVEPRTKLPLYTVGLSVLITMLLGLINIGSSAAFNAVASLVVSGYLSSYTLPMILLLHKKIFNPSSIHYGPWTLGRPFGIFCNIFGLCWIAIVMVFSFFPSVRTDLTLQTMNWSCLLWGGTMIIGITSYFGYLRGRYNGPIVERDIIDQVHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9I8</accession>
    <name>A0A0D2B9I8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235829.1">
        <property type="nucleotide sequence ID" value="XM_016380002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9I8"/>
    <dbReference type="STRING" id="91928.A0A0D2B9I8"/>
    <dbReference type="GeneID" id="27332744"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05661"/>
    <dbReference type="HOGENOM" id="CLU_046006_4_3_1"/>
    <dbReference type="OrthoDB" id="5371818at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07253">
        <property type="entry name" value="GLOD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050383">
        <property type="entry name" value="GlyoxalaseI/FosfomycinResist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366:SF14">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="133" mass="14593" checksum="0FA57287EAEC6B2F" modified="2015-04-29" version="1">MSPIARAKSLDHLVLTVKDLDTTVAFYQETLGMQHTSFGAANDPRIQRHALKFGGQKINLHVSGKEFEPRAQNVQPGSSDLCFLIEDNVDGVLAKLKEKKIDVLEGGKVVHRTGAQGALRSVYIRDPDGNLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BB25</accession>
    <name>A0A0D2BB25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236424.1">
        <property type="nucleotide sequence ID" value="XM_016380597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BB25"/>
    <dbReference type="STRING" id="91928.A0A0D2BB25"/>
    <dbReference type="GeneID" id="27333342"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06259"/>
    <dbReference type="HOGENOM" id="CLU_066707_0_0_1"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29445" checksum="F82F8B5D68B98640" modified="2015-04-29" version="1">MTSTSRTHTVAFFGATGGVANAILVHTLLSGHRALALVRTPSKLRDQLNAQGLEAAVIDNNLTIVQGNALDVANVKETLLASPDGAFPTYIVTGLGGTPSLTFDWCHPGHIATLDNPTICETAARTLVAALREIYTSKEAPLQAIAKPALVFVSTTGISRGVEDVPFAMRFFYHQALAVPHIDKKKMEDVYRGEMEKGEGEGVFRTVVGIRPTLLSGSVNYKDVKGLKSLKVGTESKPALGFNVKRADVGHWVYENVISPNATGQWDGEMVSLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCD8</accession>
    <name>A0A0D2BCD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236859.1">
        <property type="nucleotide sequence ID" value="XM_016378182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCD8"/>
    <dbReference type="GeneID" id="27330914"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03831"/>
    <dbReference type="HOGENOM" id="CLU_126104_0_0_1"/>
    <dbReference type="OrthoDB" id="4121160at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="157" mass="16690" checksum="828891BA0E09753A" modified="2015-04-29" version="1">MAPPKEPNEELKFVMMCIKYSETELKPNFDEVAREVGAKSANACYQRLWAIKRKLGMTGTGHKRGTAGDGVVGTDTTTAAAAAVAAATGARKRKTTAAKVKDEDGSGDESTSVKDNTNKKKRVTKKAPTTVKEEADDDVDIGTESAPGEEVKVEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFD2</accession>
    <name>A0A0D2BFD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PV08_04903</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237924.1">
        <property type="nucleotide sequence ID" value="XM_016379247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFD2"/>
    <dbReference type="STRING" id="91928.A0A0D2BFD2"/>
    <dbReference type="GeneID" id="27331986"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04903"/>
    <dbReference type="HOGENOM" id="CLU_040334_1_1_1"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="21">
        <location>
            <begin position="97"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KIW17708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="321" mass="35330" checksum="E7B6A7E28C0BD50E" modified="2015-04-29" version="1">MLATSAIRSAPLRTAARTVVRRTTTRAASSSSSEASSSPFYITAGASAATAATVGSIAWYYHLFGQDAYAMTPAEEGLHPTQYPWEHTKWNKTFDHAALRRGFQVYQEVCAACHSLKRIPYRSLVGTFMTVDEAKALAEENEYDTEPNDEGEIEKRPGKLSDYLPSPYKNDEAARAANNGALPPDLSLIVKARHGGCNYIFSLLTGYPEEPPAGATVQSGLNFNPYFPGTGIAMARVLYDGLVEYPDGTPATTSQMAKDVVEFLNWTAEPEMDDRKKMGMKVMIIGVALLAISGWVKRYKWSPIKTRKLVYNPPLEGRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BG50</accession>
    <name>A0A0D2BG50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238169.1">
        <property type="nucleotide sequence ID" value="XM_016379492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BG50"/>
    <dbReference type="GeneID" id="27332231"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05148"/>
    <dbReference type="HOGENOM" id="CLU_000960_25_2_1"/>
    <dbReference type="OrthoDB" id="4198076at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="610" mass="65700" checksum="7C5702FD579CC30A" modified="2015-04-29" version="1">MTEDTIDTAHGEIAIEDDQKLRHVLSAAIGDEATEHVRSVGLGLVMEPRMMMVIFAMIMGQFAGIWGFTLPAGILPFIEEDIGGSSNSALFSIVWTMGNSVGYALVGRLSDIFGRRWWMIGFNALGLVGGAKLTPITGIVAGRAQRIDVLIGSNVLLGLSSGGQFSMQFMSAELVPNRHKLAMLGLVVFGCFPSLAIGSFLGRAVLEGASWRWIYYIYSISCACAVGLHFFFYHPKEPVLPKSRLQLLKELDFIGLFLFVSSIALFVLGISLGGNPYPWDSAKVLGPLVSGVVASIGFFAWELHMPISRQFMRVQLLKDLRGFAGIVVCGAMGGLIFFGLSVAWPSEVYYVYATSTDWSNNAWRTTSLGIGIWVGDCFVSPLIGIFKYAKWQLVVYAGLLTLFLGIASLCTPNDVALGIAMSGLAGVVTGPFEQAPAALSQLFVEDEDLGMAFSLFGGLRSAFGAIGSAVFLSIIHNKVPEQLAIHIGAVAASHNISASEIPLIIQELSEGQISSLLKIPGVDASVIGELAYASRWAYADAYKVAYYAAVAFGAATFLVTLTLRDLDYLLTDHVPRTIAHNAAEARIHDEKEVRIHHEEEIPATATTPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BG62</accession>
    <name>A0A0D2BG62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04795</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237816.1">
        <property type="nucleotide sequence ID" value="XM_016379139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BG62"/>
    <dbReference type="STRING" id="91928.A0A0D2BG62"/>
    <dbReference type="GeneID" id="27331878"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04795"/>
    <dbReference type="HOGENOM" id="CLU_021763_1_0_1"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07387">
        <property type="entry name" value="MPP_PolD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.50:FF:000006">
        <property type="entry name" value="DNA polymerase delta subunit 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041863">
        <property type="entry name" value="PolD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="11">
        <location>
            <begin position="46"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="10">
        <location>
            <begin position="214"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="510" mass="56828" checksum="5AD56C042971C058" modified="2015-04-29" version="1">MAPIHGLLRPWQKDEKAQEQTRVSSDYSPLYSYRLLRGENKHYVQQYGDMYFLRLAKLKPAVEAIAAEDWDDFEIAGERAQRVERVLDVRQGQLCWVVGTIYMDLPLKPNILEDISKDRWVAGPASQHPYYSENGDTQVMLEDESGRLRLTGAMLKNNVLVTGVIVAVLGTENANGDFEVLDLHVPELPSQPKRWEGDEEEEVKMDLDRPGNKIAILSGLNISGTEADTLTLSLLSEFLLGEALDTEDRQEASTISRLIIAGNSVVSDFALHQPLSDDPKKLGNRKYGYDAAAYNPSPPAQLDQFLAELLPSIPITLLPGDQDPANVSLPQQPIHPAMLPHSRAYTTANVSDPEADQPGWLDSVTNPWDGDIEGWRFMGNSGQPVDDILKYVEYGGPDGKGADGRLEVMASMLRWRCGAPTAPDTLWCYPFQDRDQFVIEQCPHVFFVGNQPRFDTTVIDGPRDQQVRLITIPKFHETGELVLVDAKTLEVEVVKFDIHDAASQLNGHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHB8</accession>
    <name>A0A0D2BHB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen debranching enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238589.1">
        <property type="nucleotide sequence ID" value="XM_016377019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHB8"/>
    <dbReference type="GeneID" id="27329744"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02661"/>
    <dbReference type="HOGENOM" id="CLU_012888_0_0_1"/>
    <dbReference type="OrthoDB" id="2591256at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254499" description="Glycogen debranching enzyme" evidence="1">
        <location>
            <begin position="19"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="80491" checksum="C9D623C3786DEE48" modified="2015-04-29" version="1">MLTILLAVFAFWLHDALAQSSGSCRAVTQHLSDPPYDNYFYSDCHSDSQVVVTSPLPDSNLSIIGPRLIVAWPAGNSGICMFFQPQNGRNGSLGIELVNSTLGSPLGPVYRENAGTKYPYVGVEGIISFNSSATLTIPILGSIRTIRDFTEGPSLLRPTIQDAVNATKANGTGATLSRLWLDNVTVSTFTLVPHQNSGTNITIHQQNRTLSFGAGLYSFSASFNYPQLTQLAPSRVLNSASQQLIQQQPDQTTSLSFLSYSEKLLAGAWRFLTYFGRDSMISALLLEPVLSQGNGSATEAVIGAVLERINRTDGSVCHEETIGDYATYLNLQDNLTSTAPGFTYPMIDTDYYLPVLMAQYFNNSPSRISPLLQRSAGSVDIQNRNLTYADLTLINAEKIMNQTAAFARNQTRANLIHLKPDEVVGQWRDSTYGIGGGRIPFDVNTALVPAALRAIGRLARTPGVFPNDSATGVNVTSWRTLADTRAQVWEDQTLRFFERNVTASAARARLQHFVDTSTFYDGPTNASSLPSSGNVTNYAISLDGNNCLSSVDVLHSDSAFRLFFVNATPSTPDAQAQETRFINATANSLVRPFPAGLMTPQSMVVANPALSGSDVLIANFTNAAYHGTVVWSFQLAMMAKGLERQLGRCNGSSSSSSPSSAVPSWCNDKSVYGTVKRAYNLLWDSIEANEAQLQGEVWSWTYSNGTGFVTTPLGVLSSGTESDIRQLWSLTFLAVKRDTNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIV6</accession>
    <name>A0A0D2BIV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell division control protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238711.1">
        <property type="nucleotide sequence ID" value="XM_016377141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIV6"/>
    <dbReference type="STRING" id="91928.A0A0D2BIV6"/>
    <dbReference type="GeneID" id="27329866"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02783"/>
    <dbReference type="HOGENOM" id="CLU_005871_3_0_1"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="703"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="707"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="746"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW18495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="92126" checksum="32ABC12E13483C95" modified="2015-04-29" version="1">MYLPRELISQLYTNLVRSHHPLSPPVLLLVALEPDALCACRILTALFKRDYIPHKIQPVSGYADLARAGEDLIRPMKTSEGGSGGVVICLGVGGLVDLGSLLGLEDENSSEAMCGVEVWVLDARRPWNLSNVFGGLPMDAQTAETDTAMRRTPGVDKGCIQKSYRSGRGGIIVFDDGDIATELGTEREAYCTLSSMPDVGEDESDDEDSGDEDEDSQDTSSSRKRKSWSDRDDEGDESEMDEERPRQRRRSNSGSSIASTPRSRSPSSSQLTSPVSKPQSPGLQTAKQLRKRLRKLREKHERVLQEYNGLGTSYSEPIASMAYSLATDLGREDNDLLWLAIIGVTSLELYGHTSTGLGTSVSITNTHEHHRSWRATRSSQTYALLRDEVRRLNPPPADRSPTISPSGGGTSSPSDTSIRLTPDPRFLLLRHWSLYDSMLHSPYLASRLHVWNESGVKYLHKLLAKMGVSLTQCKQTYTHMDMDLKKTLRERLLKYAGVYGLDDLVPSGSGRASYEQEGWGFIRSWGWKAQLSAVDVGVILGAILDIGTTHTPAVSNPAAQNGSSQRTNIADDVPDRSEALLPRFFAAYDALAPNHPSHLLTAIPTAQHLLRSILRTGSSLMVKHQIRHLRAFRMGVVKDGPDLGLFANSPGALVKLALWVGEAVAVKEKDKKGSEAPTPLVLAALDEARGTYVVVGTGGGIGGSEDLEARKEKAERKAKREEAKEAKRKIREEKRAARKAARELNGDDDVDDGDEDSESSEEEDESEDESDEEDEEELARRKKRGYGHNRFGIAFQEVVEETNARVKIDSFDHCIVEVKKEDLGGFLEGLSLKAVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKR5</accession>
    <name>A0A0D2BKR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_03484</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239406.1">
        <property type="nucleotide sequence ID" value="XM_016377836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKR5"/>
    <dbReference type="STRING" id="91928.A0A0D2BKR5"/>
    <dbReference type="GeneID" id="27330567"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03484"/>
    <dbReference type="HOGENOM" id="CLU_000631_11_0_1"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000138">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239183" description="alpha-glucosidase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="10">
        <location>
            <begin position="332"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="11">
        <location>
            <begin position="772"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW19190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="999" mass="108324" checksum="BC79735461C7FE46" modified="2015-04-29" version="1">MNLVAFFTSLLAVPCLAVPQTSTAASRASSTTSFTPQFTVPASADEGATLLPNIYDPTAADAQAECPGYNATGVKTSSTGLTAHLALAGSACNVYGTDVHDLDLTVEYQTDKRLHINIRPSHVSSENQSWYLLSTDYVPAPSQEQGTMTTSDLTFSWANTASSGFGFNVTRNGTGDVLFSTAGTKLVFENQFIELVTRQEENYNLYGLGEVIHGLRLGNNLTRTLYAADVGDPIDMNIYGSHPFYLQTKYFEVGSDNSTRLVTKPVDSTSDTANYTSSSHGVYFRNAHGMEVLLRPDNVTWRTLGGSIDLYFFSGPSQPDVTQQYLNVIGQPVLQNYWGFGFHQCRWGYENWTVTEGVVDNYAKFGIPLETIWNDIDYMFQYRDFDNDPVRFNYSDGKAFLQRLHDKGQHYVPIIDSAIYAPNPDNQSDAYATFNDGNDTNSYLLNPDGSLYIGSVWPGYTVFPDWLTSAAHAWWKNQMVIWHQKIPIDGAWIDMSEVSSFCVGSCGTGNLSLNPVHPPFKLPGEPGNIIYDYPEGFNLTNATQAASAASASQSQADATLTASSTTVNSASSSSTSYLRTTPTAGVRNVNHPPYVINNVQGDLAVHAVSPNATHHNGIEEYDVHNLFGHQILQATYGALLAARPGKRPFIIGRSTFPGSGTVAGHWGGDNMSKFYYMYFSIPQALSFSLFGIPMFGVDTCGFNGNSDEELCNRWMQLSAFFPFYRNHNVLSANSQEAYVWSSVIDATKTAMNVRFQLLPYLYTLFYNAHTAGDTVMRALAWEFPNDPSLADADRQFFLGPSILVTPVLTQGATTVDGVFPGVVEGTDVYYDWYNKTPVSVPSSKNTTIDAPLGHIPVYIRGGAVLATQQMAMTTRDARNTSWSIIVAPGVDGTATGQLYLDDGESLSPNATKSVTLAAGVGIGGLSLNVTVTGSYTGLDLPLANVTILGVQRAPSSNVVKIDGEAVGNSTYDGTTKTLFIGGLGGALGGKAWGGNWTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL37</accession>
    <name>A0A0D2BL37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2241 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239889.1">
        <property type="nucleotide sequence ID" value="XM_016374613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL37"/>
    <dbReference type="STRING" id="91928.A0A0D2BL37"/>
    <dbReference type="GeneID" id="27327330"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00247"/>
    <dbReference type="HOGENOM" id="CLU_113369_0_0_1"/>
    <dbReference type="OrthoDB" id="10064407at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018717">
        <property type="entry name" value="DUF2241"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39199">
        <property type="entry name" value="BLR5128 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39199:SF1">
        <property type="entry name" value="BLR5128 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10000">
        <property type="entry name" value="ACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2241" evidence="1">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="148" mass="16386" checksum="6A86F049F82C355F" modified="2015-04-29" version="1">MAAVGETSLQTLLSSLTLVLHEPTYVFLTIPHEQFRSPFMIPFADILLSFREAEGVTLVVTQSLAEQHALAYQYPCRMITCNVHSSLEAVGFMAHLATKLAGKGLSVNPVSGYFHDHLFVPVEKAREAVEVLEKVREDAERATTSLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLF1</accession>
    <name>A0A0D2BLF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239616.1">
        <property type="nucleotide sequence ID" value="XM_016378046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLF1"/>
    <dbReference type="GeneID" id="27330778"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03695"/>
    <dbReference type="HOGENOM" id="CLU_031002_0_1_1"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="433" mass="46836" checksum="D628DA70F844BC64" modified="2015-04-29" version="1">MAAKRQYDIILLGATGYTGKLTAEYITSSLPTSIKWAVAGRNQSKLEALVKELKSINSTRTAPDVVTVANLTAPEMVTLAKKTRVLLNTVGPYHLYSTPVVEACAQTGTHYVDATGETPWVREIITKYEAAAKKSGAIIIPENGIESAPSDLVAYIATRLVRKVWDCGVMDVVASVHEMKSSGPSGGTLATGLSIFDHYSGKVIKESMDPFCLSPTRLKPYTKDTLYPPNPEPNTYARTGLQKLTGVWSYPRLGNLVTSISAKPNVAIVHRSAGLTPYFYGFNFTYEEYMAVGSPLVGVLIHFALVLLGFFLAFPPTRAILKLFASYKPGSGPTKESTKGDVLELRAIAVAEQLAKQPRKALATFRFEGGFYQLTAIFLAEAAVVLLSKEEEVKKAHGAGFLTPSCLGDDYLDRLDKANVKIGVQQIGDVGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLK8</accession>
    <name>A0A0D2BLK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239666.1">
        <property type="nucleotide sequence ID" value="XM_016374390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLK8"/>
    <dbReference type="GeneID" id="27327105"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00022"/>
    <dbReference type="HOGENOM" id="CLU_029940_1_0_1"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="305" mass="35282" checksum="5F0954A18E7A1E3C" modified="2015-04-29" version="1">MKKVQIGYGVDVDAVSGWIGSYGGEDSICDISRGLQAGEVNVHRLLKMFKKYNMTQTFYIPGHSLETFPNECAAIRDAGHEIGLHGYSHEEPNKLSPQQQEDVFNHTYDLLTKFVGEPPKGIVTPMCQISEASAQLLVDKGMEYDHSAMHRDCVPYYLRVGDQWEKVDPSKPASSWMKPLVRGKLTDLVEIPMNWFQDDFIPLTFVQNMPNCGGWQDPDTIIKIWKERFEYFYREYDYFIFPMCIHPDASGHPHVIMAHERFIEWVNTHEGVEWVPIYQMARTFRKMYPTKEDWLKAEEANGTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLY5</accession>
    <name>A0A0D2BLY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative peptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZPS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240164.1">
        <property type="nucleotide sequence ID" value="XM_016374888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLY5"/>
    <dbReference type="STRING" id="91928.A0A0D2BLY5"/>
    <dbReference type="GeneID" id="27327606"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00523"/>
    <dbReference type="HOGENOM" id="CLU_048223_0_0_1"/>
    <dbReference type="OrthoDB" id="4689212at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11307">
        <property type="entry name" value="M35_Asp_f2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000043">
        <property type="entry name" value="Major allergen Asp F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029482">
        <property type="entry name" value="HRXXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039124">
        <property type="entry name" value="PRA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399:SF1">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13933">
        <property type="entry name" value="HRXXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254627" description="Putative peptidase domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Putative peptidase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="301" mass="32006" checksum="33FDD2A5B716FC9C" modified="2015-04-29" version="1">MPGLVSALTVALATVASAAPALLAVRQEAPFTTTSTAWDAGAVTQFPIHSSCNATQARQLAVGLNETILLVEHAKEHILRWGNKSEIYQKYFGNRPPYDAIGAYEIVINGDKSGVLFRCDNPDGNCALEGWGGHWRGENATGETVICDLSYETRRSLNQMCALGYNVAGSKANTFWASDLLHRLYHIPAIGGEYVEHFAGDYDEVIELAQSNGTESTRDSDTLQFFALEAYAYDIAVPGQGCPGGSNDHDHDHDHSSSASATPAPAPASTTGSPTATQPPSTTSSLPANCHTHEGGDVHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMI2</accession>
    <name>A0A0D2BMI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240359.1">
        <property type="nucleotide sequence ID" value="XM_016375083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMI2"/>
    <dbReference type="STRING" id="91928.A0A0D2BMI2"/>
    <dbReference type="GeneID" id="27327801"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00718"/>
    <dbReference type="HOGENOM" id="CLU_061199_0_0_1"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33875" checksum="41F7F4049B94D481" modified="2015-04-29" version="1">MASGIPYTPKPATDIFTPYQTDINRRECKRIVPMRVLALGLGRTGTASLRAALKELGYTDTYHMMSASVENPPDCLCWMDAFAAKYEGKGKFGREEWDALLGHCQAVCDWPAVAFAKELIEAYPEAKVIITTRDVDSWHSSVMKTVNWRANDPELRAVANFDWAAGLYHPMLRKFWKYFFNDDFEQSGKQRFHDYYKEIREMVPPGKLLEYRVSSGWRPLCEYLGEPVPDKPFPRSNDADGFVERCRTQNRKQMMNVIFRALVVGVPVVATALSATFAYTHYLPKVAQHTSLFTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNL7</accession>
    <name>A0A0D2BNL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240341.1">
        <property type="nucleotide sequence ID" value="XM_016375065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNL7"/>
    <dbReference type="STRING" id="91928.A0A0D2BNL7"/>
    <dbReference type="GeneID" id="27327783"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00700"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="485" mass="51748" checksum="1057E211DF9CF90C" modified="2015-04-29" version="1">MVLSPDEYKSELFINNEFVSSKGSERLTLTNPWDESTVATDVHVANAADVDSAVAASVQAVKKGPWKKFTGAQRAACMLKFADLAEKNAEKLARLESLPTGRPVSMITHFDIPNMVSVFRYYAGWADKIAGKTFPEDNGVYKIVRYEPMGVCAGIASWNATFLYVGWKIAPALAAGCSFIFKASEKSPLGVLALAPLFAEAGFPPGVVQFLTGARVTGEALASHMDIAKISFTGSVGGGRAVQQAALKSNMKRVTLELGGKSPAIVFNDAPLEAAVGGVGQGFLVNSGQICVAASRVLVQEDIAEKFQEAVKAQFEAVRDGLGQNPLEPTTTHGPVVDKSQYDRVMGYIDVGKDTAQLLTGGGRKGDKGFAIEPTIFVNPKPGSKIWSEEIFGPVLSIKTFKTEEEAIEIANDTTYGLASVIYTKSLNRGLRVSSALETGGVSINFPFIPETQTPFGGMKQSGSGRELGEEGLKAYLEPKTINIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP33</accession>
    <name>A0A0D2BP33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hypercellular protein HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_01255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240894.1">
        <property type="nucleotide sequence ID" value="XM_016375618.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BP33"/>
    <dbReference type="GeneID" id="27328338"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01255"/>
    <dbReference type="HOGENOM" id="CLU_002231_0_0_1"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="359"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="673"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1238"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1371" mass="150943" checksum="00A2EF0DFB48A912" modified="2015-04-29" version="1">MGYNPFDPIAGAKVNVLCVPAGQITPDRFQRFVKTLQKSAIIPLEDVEPSATGKGTGDQQLIEREACSNYGSPERQDGQIFYDISTYQDARRPDFFPFDTNSRSQILLGLIDGHRVEGLSQSASLDQAAPHGISAAHQSIKDAFLHQSPSIPGLLVRQLIWFGSQPPTDLGQDPLFVPDEDNRNAAHDVMVSLSRMFMSRTTDTIDELKNQPISMVPGMVPGVNSSLPLRGGRTPNLEDGNSNPTSTRSPNATPVLQETEAQSETSRGRFNIIQGMLRLQNGLWTHALDCLSDGISIAQNGHDHLWHGKALESLLVCMIILSWSNSSFTIPQVCRSLPNRNGYLQTDSGPKSAKSGKALAQLMPPMVETILELYAKVSNLDLGGSLQDVLREARVRLVNLLVCVKRNGNILSQECLNQIVTGQRGVADSRETSGEPVAISKAGMANILIETLQAAQSSNSIGHYTTILVAVSSSLSTLGLDRKHAFYLKMLMQQLVPKLIEARKVGASEVGVHPAAGLPPVSNASQGIIPEMAAGTRLALDLAAAAYGLPLSPVPNPQEVIPANLEVIRDKLQAWAIEHSFGDTLLKIEMLRICVVACDALPDIPASLHFTSSILRTAKQVITMPLQEPCLAIPLITAEEQSKFVESLKRAIAAASRIGESGYRAEYWDDFLVRDVQVFERDSFSKLIPHKPSDLSIQGTTNLAETVRDPFIYNPFSKAKSVAAAPVLVAEELATFAVVLQNPLEVDVEIDQIELITTGCEFTASKHSIVLGPFSTQTFTLTGRPSGSGDLEVIGCRASIRHCYPQDFLIFTDDWKLPSSPKDNAVGKIKTRRKPNGVPDEDIATGTNLKLQTPISTSLKLRVINPQPRLTIQPTNFDSAAMMLLEGELRRYDFKMINESSRVSADFVLVTTQDSVTSRLQDTLENKDLLPADIYEIQTQLATNPVVQIENKDRPDSSSSLSPGQSINYTVAIVGRPGLVSATVQMDFAYLGAPSSEVKGNFYTRQVRYPISVTVNGSVEILRCNILPIHNDFSWNDKLRQTIYQNGDEVDKSHKRNIAHFSHWLKTHQDAHDHCILSLDVRNVWPQPLSIHIQARRPTWGDTAPDGRWNEAFSVLETLQPGHVSRILLLVPRLFIQDPTASIPNLGTQKQFVVSKSKVSAETEAASRESFWYREELIKCLRGTWNEEPSGRKGTIDLRKGIRLSSRMVDALKSDHVEIEYDLLPAEKSDAQSADESADGQTIQQIGRYHFAMKTEVFTTLSVRVHNRTRDTLRLLLRLQPSLRNQPHNIALDLSRRLAWTGVLQRALHPAIEPGGVCVAQLGIIALAQGDYEINASVEEVKGFRTDPPTVGSGRRMWHARSPCLIDAIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPC8</accession>
    <name>A0A0D2BPC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1772 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240586.1">
        <property type="nucleotide sequence ID" value="XM_016375310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPC8"/>
    <dbReference type="STRING" id="91928.A0A0D2BPC8"/>
    <dbReference type="GeneID" id="27328028"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00945"/>
    <dbReference type="HOGENOM" id="CLU_105974_3_0_1"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="16826" checksum="88F8ECE6BCD97814" modified="2015-04-29" version="1">MDSTTVLRATSFLGVSSSIWLSGISFSQSYLTIPLLVGIPSETSTALFKDLYYSGAKLIVPLALTSTLSTATAAYLDAEKRAGYAVAAAATISILPFTAAVMFPCIHRLIAIADDAKVREKTQPGEVAGLLTQWKWMNYVRAGLSGVGGVVGLLVYSGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPI1</accession>
    <name>A0A0D2BPI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_01005</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240646.1">
        <property type="nucleotide sequence ID" value="XM_016375370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPI1"/>
    <dbReference type="STRING" id="91928.A0A0D2BPI1"/>
    <dbReference type="GeneID" id="27328088"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01005"/>
    <dbReference type="HOGENOM" id="CLU_005646_3_0_1"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000004">
        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="308"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW20430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="601" mass="67884" checksum="0E7B651BEB25406E" modified="2015-04-29" version="1">MNSTSPPPYFYEVPLGRSNTTTHDNAPMYYLEKPLARSNTMSATSVMTERTRSTPLSRLLLSGEVSGEAPRGLTAKEKLERWMVNEGSRRVVVGLFVLVHALIFAFGFMNYQLKDNLTTARATFGITYPIARSAALVLHFDVALILFPVCRTLISLLRQTPLNSIVPFDKNITFHKTVAYSIVFFTWVHTIAHWNNFAQLAAKQNVGFVGFLKINFLTGPGWSGYVMLFALMAMFFTSIEKPRRANYERFWSIHHLFIVFFGFWSVHGAFCMIKTDSPPFCFGTGVFWEYWMYGGFAYLLERVLREVRGRHKTYVTKVIQHPSNVVEIQMHKERTKTRAGQYIFLCCPEISIWQYHPFTLTSAPEEDYISVHVRMVGNFTKALGKALGCEEGKGARGGDKRSEVVSMAPGAGLTKLLPRIYVDGPFGSASEDVFKFETAVLVGAGIGVTPFASILKSIWYRMSAGRDSNIRLRKVYFFWVCRDFGSLEWFKSLLMAIESQDKQHKIEIHAYLTAKISAADANNIMLNSTDADAITGLRTPTNFGRPNWDMVFRAVRKLHSPGEAGVFFCGPKGLGSQLHIKCNMYSEGAKGFNFVWGKENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPM8</accession>
    <name>A0A0D2BPM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233250.1">
        <property type="nucleotide sequence ID" value="XM_016382547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPM8"/>
    <dbReference type="STRING" id="91928.A0A0D2BPM8"/>
    <dbReference type="GeneID" id="27335304"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08221"/>
    <dbReference type="HOGENOM" id="CLU_014251_1_1_1"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250021" evidence="2">
        <location>
            <begin position="17"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="4">
        <location>
            <begin position="155"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="3">
        <location>
            <begin position="345"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="765" mass="83706" checksum="AD41A54331BD7F8F" modified="2015-04-29" version="1">MFPFAFSLFLVSGALGQSVSQPSPTSTLEPCAQIRELQKTSLAADPAATVFRFPPEVAYECQLSVPIVQNDAFQIIDGLRALVEWQSTLGWLKNPPAGYPFRPVDLVGGLEELRSQVQSGHLKSELEFEWKLIGLLSSARDGHLQFHPDADFVFSFRNPIGNLVSVSSDGRALPEVYLYSELIRGISEGWEPSAISKLNDIDIVEWLTYEALNTTFTFQDPDANYNFLFYSNTGSDGAFFANAESRYNGTDMTVNFKNGSTASYGWVAATAKSFAAVEDGTSFYNAFCNVTQKLSNTDPGSSAATSDASPGASDPNQLRPLYPKALVISDDASIAGYFSESDPDTAILSINGFSEGAAPSAQQTMTSFLNMCREQNKTRLIIDLSQNGGGTIMLAYDYFKQLFPSLEPYLAGQLRAHEQLDVLGQYFTPLAEQAQRDDPSNLTYLTDRGRYGYFDARSFVNDSGQIFDSWDDFYGPVDRNGDKFTNLFQLYIRNADYDHSSGAITVSGYANNSEIAPQPFDPENIITFTDGYCASACTIFMHLMRYQAKVKTIVAGGRPQMGPMQYVGGVKGSLDMPLDYVYNQTKYLYDHAPKEMIERANKTLLKSILDYGSYLQLRSVSPQALPSVNGQNAISQYDSSETPLQFVTEAADCRIWFQPIHMVNITALWDTVGQQAFGLNDTKPYSLCVKGSTNDPTSLNGNGTFYDDGRLANVTGYDPDNNGTVSGTEDGNNSGSIDGTNGASSLSNGPTILMVLALCSFSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPS7</accession>
    <name>A0A0D2BPS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08311</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233340.1">
        <property type="nucleotide sequence ID" value="XM_016382637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPS7"/>
    <dbReference type="STRING" id="91928.A0A0D2BPS7"/>
    <dbReference type="GeneID" id="27335394"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08311"/>
    <dbReference type="HOGENOM" id="CLU_077168_0_1_1"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001607">
        <property type="entry name" value="Gluconokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="224" mass="25636" checksum="5097738A348E223C" modified="2015-04-29" version="1">MLSAERIPRHQPFRYQTSTTKAALDVSVREMAAEGDEHIEHIWIITGPAGCGKTTVAQHLAQELSLPYVEGDDFHPVANKQKMASGIPLTDADRWDWLITLRNEAIKQLQHSNGVIVTCSALKHKYRDVIRVANYEHPSVQVHFVYLKVDETTLQKRVAARVGHYMKEGMVHSQMATLEEPELDEEWDVLPVDVRDDKETVKKHALEVVQRKLKEYESLPKRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPU9</accession>
    <name>A0A0D2BPU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_01095</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240736.1">
        <property type="nucleotide sequence ID" value="XM_016375460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPU9"/>
    <dbReference type="STRING" id="91928.A0A0D2BPU9"/>
    <dbReference type="GeneID" id="27328178"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01095"/>
    <dbReference type="HOGENOM" id="CLU_027174_0_1_1"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="31"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="307"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW20520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="498" mass="55303" checksum="09AB422C087FE65B" modified="2015-04-29" version="1">MITAIQPPISYGRTAQSGFITTATDLDPYSYQVGYGNRFATEAIPGTLPQGRNTPQKCKYDLFSEQLNGTPFVSARASQQHAWFYRIRPSVAHRPVTTSVDNPNLVASFAATNPSTKFLARDQSWGAFPIPEESDPVDFVQGIKTIGGHGDAMSKEGLAVHAYTANRSMGKTAFCNNDGDFLILPQHGRLDIQTEFGHLMVRPGELVVIPAGIRFKVELPDGTARGYIQEIFGAHFELPELGPVGSNGMAMPRDFEYPVASFDVDQTVWTIVVKLAGRLFEYEQEHTPFDVVAWHGNYAPYKYATEKFVNSATVEKEQSDPSIYCVLMAKSKTAGVALTELLVFTPRWSVTTNSFRPPYYHRNVCTELMGMVYGDWKGSATLLEPGGLTYEPSLMPHGESYERWSEATTTELVPERVNENTLAFMLHISGHIALTDYALEKSGTLHEIQANFWDGFDSGFTKHIDQIDRDLASAGLGGLRRPEKTKEANELDSEIMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPW8</accession>
    <name>A0A0D2BPW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_01115</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240756.1">
        <property type="nucleotide sequence ID" value="XM_016375480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPW8"/>
    <dbReference type="STRING" id="91928.A0A0D2BPW8"/>
    <dbReference type="GeneID" id="27328198"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01115"/>
    <dbReference type="HOGENOM" id="CLU_030047_0_0_1"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW20540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="542" mass="60810" checksum="DD411E38B7F0CBAC" modified="2015-04-29" version="1">MRRRSTFITHPSRAVNPADIQVYENQLLLGALKAAREERLTLGLKELPEEVVEVLQEAHELHIRWTREETYHSSPPFLSRTSPGLHVQYTPLKEDQPDHLCKLLQKVFGDQVHCKSPKATFISPPLISERFAQTASSHYYTLLPTVRHLASYLQRTICKPSDLSCIHTATLLNLADVIDFDYDSISHALILTVQWSKQPEVIWDPIGDFTTFDAWNLDIQSSPNDKVEVGILSPSPATEPSDLQLSGFLTTVGSDDHPKATLFSFPSRHHTLGPAQRRDQRYTVSFEQPTGLHPILKISFPNGESLVEPQTKPPGSVCALQTYVTLPSHLFADKYAFLSNDPLFQKSHNLGQLHSIAGETDLEAPDYVVDRWGSTMLLDIRTPDTDEGGEENKKKHDERTASSTQWNVTIPLHLRYLEPSSGGHSEVEMPWPIVFWACTAEEGTKFPVNPFDRIHLGYDGLFGPRTMFYHLDPAPEVGSSGRLVERISVPVLDTETASPRTIELVTLATIALGFVWVLLKLRIPSLLSSSSRAEKPVIKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ61</accession>
    <name>A0A0D2BQ61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241289.1">
        <property type="nucleotide sequence ID" value="XM_016376013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ61"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ61"/>
    <dbReference type="GeneID" id="27328735"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01652"/>
    <dbReference type="HOGENOM" id="CLU_035888_1_0_1"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="428" mass="48695" checksum="80EEF96077E52DE9" modified="2015-04-29" version="1">MPSEIGAPQQHRQSSRKGKKAWRKNVDITEVQTGLETLREEILQGGPIAEKASEELFALDTKGSEDIKKKYKLQKPLKVDEILSRRSAVPALDSRKRPHSAVGDGVITSSKRQKPDWVSKKEIQRLRNNLDKTTFLDNQNIEAENADFDPWAVESVPLSSKDDSEEYLPKPKPKVAPATIRRAPIAMTASGRPVRAVQQPEGGASYNPAFEDWDELLNKEGERELQAEKARLLEAQIAAEKEQRIQQLASAPDPNPADEESAWEGFETENDDPELLNKKRPQRKTPAQRNKIKRRKEAERLARHEKRMGDKQKQAEQIINSLILQQERENDLASKGEPSEPVGTDDRALRRRKLGTAPILQKPLEVVLPDELQDSLRRLKPEGNLLNDRFRNLLVNGKLESRKPILQPKKAKKKITEKWSYKDFSVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQD9</accession>
    <name>A0A0D2BQD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240921.1">
        <property type="nucleotide sequence ID" value="XM_016375645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQD9"/>
    <dbReference type="STRING" id="91928.A0A0D2BQD9"/>
    <dbReference type="GeneID" id="27328365"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01282"/>
    <dbReference type="HOGENOM" id="CLU_004804_0_2_1"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="789" mass="86852" checksum="F95B558F385CC2F9" modified="2015-04-29" version="1">MNADQQCERGEVESKRKRLRKGTHSCWECKRRKVRCTFASSTDSTCITCQRRGTRCIGQDVPEEECPVDDGAGSMERVEALLNKLVKNIDHRTTEDRPRRQSVQTQESHGRMNSSRAASRPPPAPSVSSRESPAGGILQGSRDWNAFLTAPSDCTPEFQASPISWTSVSKASGQDKISQALFASFPSQNEINTLMKANPGFSQICPRIKSGFFHRSTGEIAGAAKELGPQTHPVLLAKHMLMVAALLMGFPRHQQAPGVLEHHHSVMLKLADAAISLVTTNDEFSSSLESLECILLEGQHHSNCGNIRRAWLAHRRALMVAQLLALDRVNGPAPRRLDPETKTNRASLWTHVLYVDRFVSLMLGLPPGNTDITSNPEVHAAPANEKPREGLESFHAVVSVKIFERNQLRPSQQVMAQTLEIDRELRKTAETIPANFWRPAECSGMQTDTEDALEEALRIRDHVTHFSLLNQLHLPYLLCPSSGLNEYSRTSCIYASREILSRFITFRTLNTISACCRLADFLAVVAGITLVLAHIDGHRVAKNGNALSHQRLGDRAVVEKVLEEVEVISKPNDDMLTAKCVDVLRRLLRIEADAAEWHEERTDEAKGAGNGRDDGRDSNGIFLMTGPYCGTFKVSKRGIEFLEEGPDDAPSPDHPGQGIKLGGIGTIRVVEGTIADDHERELPTAALQMGVGRQHGYVSPPSENDQPPHALTDADNLQMTNASALPSDDFMMQNTNIYPASVTPGANEWAIPGMDGVFFDSLIMMQMDPQAANGDASSDWTRSMNAYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQT7</accession>
    <name>A0A0D2BQT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241584.1">
        <property type="nucleotide sequence ID" value="XM_016376308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQT7"/>
    <dbReference type="GeneID" id="27329031"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01948"/>
    <dbReference type="HOGENOM" id="CLU_2605824_0_0_1"/>
    <dbReference type="OrthoDB" id="5218421at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="80" mass="8713" checksum="0A319F053E10058B" modified="2015-04-29" version="1">MPASVEYLTTPSEPFGSNSDPLVAMTSYAKMMHMHTQQQMEAATRSARRRSSPTHGVDAHAQNGLSKQSTHSSNSSRSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR73</accession>
    <name>A0A0D2BR73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241151.1">
        <property type="nucleotide sequence ID" value="XM_016375875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR73"/>
    <dbReference type="GeneID" id="27328597"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01514"/>
    <dbReference type="HOGENOM" id="CLU_2250201_0_0_1"/>
    <dbReference type="OrthoDB" id="10416599at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="129" mass="14399" checksum="5F1AD1A91784909B" modified="2015-04-29" version="1">MCFRDHIPDPTQQPIRITQSPEASHDSELKSHGDSARHVPPHRHHSTASTNTKTAAAAKNDHHRSQSQSQSQSQSGRSLSTTSDHHNYNDNTTSHTKSAKELRRLKAKDPNVIDKMNMYPPRAMIVGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRS9</accession>
    <name>A0A0D2BRS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234145.1">
        <property type="nucleotide sequence ID" value="XM_016381043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRS9"/>
    <dbReference type="STRING" id="91928.A0A0D2BRS9"/>
    <dbReference type="GeneID" id="27333793"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06710"/>
    <dbReference type="HOGENOM" id="CLU_009665_3_2_1"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="310"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="429" mass="48020" checksum="EC7A672DEE76CBDC" modified="2015-04-29" version="1">MATTSSKPIIVIGAGLVGLTLAQGLKKAGFPFEIYDRDTSLDARPAGWGITVHWSLPSLQACLPRELYDRIPSIQVDPAAGERAHDRYRFLDLETGKDKYAMPSGHHYRLNRQKLRQLLCTDIPVHWGKTFKSLELEEDGVVVHFNDGTRVEGSMLLGVDGKNSRIKRLLLGEEESRLNPLPVAFMGFTLRFSPTKMQPFRDIHPVLWQGCHPRSGYFVFFSMLSTPESNGSAATEHPYYEGQFNMSWLTSKHGPTPKTPAEQLAKAKEAACAASGMFPPLRQAILEIPDDTHALEIALEDWPTQEWPLYDGRVTLLGDAAHTMTMYRGEAANHGMYDAAALVHQLNQWRRGVKSRLEALQDSQAEVVERTHEAVLLSRYACLECHDLENLRDDSQVFQVSGFNARVKEERAAFDLSPDPLPMPAEIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BS72</accession>
    <name>A0A0D2BS72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_01865</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TFS-II family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241501.1">
        <property type="nucleotide sequence ID" value="XM_016376225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BS72"/>
    <dbReference type="STRING" id="91928.A0A0D2BS72"/>
    <dbReference type="GeneID" id="27328948"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01865"/>
    <dbReference type="HOGENOM" id="CLU_037637_1_1_1"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="12">
        <location>
            <begin position="142"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW21285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="305" mass="33474" checksum="24454C3356B0F359" modified="2015-04-29" version="1">MDRREVLSKGSALQKAIAAKEPSENIMTILRDLKANVRPSEELLRATGIGKIVNKVKGVPNLDPQVGQLASEIISRWRHVVNEQKLASGTSTPVGARTNGTSSPAPKPGTPTPKAASPGVAPDKRNWKADKVRRDEITNDSARNNCIGLIYDGLCLGSELPTKHILELAQQVESAALNLPEAKGSSASAAYKEKMRSLYQNLKNKSNPGLRKRILSGEISAARFVTMSHEEMKSQQQREEDRKIAKENMDKAMVAQEEKSVSTSLECGKCHQKKVSYSQAQTRSADEPMTTFCECLNCGNRWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSG4</accession>
    <name>A0A0D2BSG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_01950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241586.1">
        <property type="nucleotide sequence ID" value="XM_016376310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSG4"/>
    <dbReference type="STRING" id="91928.A0A0D2BSG4"/>
    <dbReference type="GeneID" id="27329033"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01950"/>
    <dbReference type="HOGENOM" id="CLU_053731_0_1_1"/>
    <dbReference type="OrthoDB" id="5368863at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="207"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="301"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW21370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="360" mass="40865" checksum="F0C5217BC8CC483F" modified="2015-04-29" version="1">MSARPTTPTRSGEPPSSPLTPEQVRRIEINRLKAKALREQRDAEAAPVYPAQPADGAVAGQKRSFATFAGATTSNRDARSPINPTRPLEAIQPARNFAKYVEYDFSKMTDTKGGFLTADDDPHNKALHTDEQDPKPTHMTQREWERAQLLRSLRNQKAGPFEPGISAAKDEDTKSCRDCGTQEVDWKWLEVFGIAVCNACKDKFPEKYSLLTKTEAKEDYLLTDPELKDEKLLPHLERPNPHKSTWHNMFLYLRCQVEEYAFSEKKWGSAEALDAEFERRQDDKKRRKESKFKSRLADLKKRTRVEAHQRSRKGGGGNFGDDIGEGKHVHEFGRPIDNPESGIPVKKCIICGLEVEEMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSV5</accession>
    <name>A0A0D2BSV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_07146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234580.1">
        <property type="nucleotide sequence ID" value="XM_016381478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSV5"/>
    <dbReference type="STRING" id="91928.A0A0D2BSV5"/>
    <dbReference type="GeneID" id="27334229"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07146"/>
    <dbReference type="HOGENOM" id="CLU_010119_4_0_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="193"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW14364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="352" mass="39330" checksum="232CEFD93FB72DFC" modified="2015-04-29" version="1">MATATTSLTMQQHGTLPPFPETLSHAPIAEISSRKLLAKDLETTAAVWKACQTYGFFYLDMTDSDQGCKLVADAEQLYGLSKETFALPFQEKDKYDFRRRKSFFGYKPSGSVKKTDTSQRPDTTEFFNVGKDCLFDVAPSNPYPDIIQNARPLLRDFCKGAHEMAMEILRTLARAADEDEEIFVNLNRFEESSGDHIRLTLKRPSDEKKSEIGLPSHTDFGSVTILFNWLGGLQIESRTPGRIGEWEYVKPVPGKAIINLGDAMVSFSNGALKSAKHRVVESPGAQAGIERVSVVYFVRPTHHSLMKPVGKFDSGGSRVKVGGKFSDGIDEKVYTAKEWLEERFVQLSHSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXC7</accession>
    <name>A0A0D2BXC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone deacetylation protein Rxt3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236155.1">
        <property type="nucleotide sequence ID" value="XM_016380328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BXC7"/>
    <dbReference type="STRING" id="91928.A0A0D2BXC7"/>
    <dbReference type="GeneID" id="27333072"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05989"/>
    <dbReference type="HOGENOM" id="CLU_005227_0_0_1"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="94965" checksum="E7095E4ACE910BCF" modified="2015-04-29" version="1">MYGPQSRSMLPPSPQQQFPSQRFPQPPLPHPSSGPTVNNGPPPSYKRPGSSMSISSMLGGEPEKPAHDQYHHHHSQASSTSSRQPSGSGPSMSLGAVMSPPQYSSKPNLGEYTYKPRSKTPDRFGNTATGARPHRSSSGTMTQGPGPFYETQPRNGPSTNTYPSPSFGASMPPRDEIDEHSRRTSISGILQRPESQPQPSMTTSLSVVPPPPTRPESIPPSLVHLDRSSHPSVSGIDPPRQNGYSGSYGYSHQQSANLSRPVHAGPPSQPTSAPIERPYKQSQSPELRRPQQNGNDTRPYQSPYGTAVEPSYGAHAMARQDSVQSQSDRSVLGDRLRNRPYSPFAGSVASQSGAIDDQVRKGSDELSQHRAILGLSSESKRGRYSPLPQAVQGAQAQTPVPDAGIKSEHGRVFSGIGSGLGTTSANPTPTPQPLPASPFKQNDANARLSEENLMKMSRSASGMGKRSRKTFDEDARAESDTGEMKKAAPTRGKRSKYQHSYKLDLEETARKNALGTIRRTGTPTSHPSLSALQRQSSATDHASLFRPKRIIRISNVVAIAGRNKRRHLGFYKYDPEVTSVDINKPSSPKFDISIRPNLLPVFNEAEQINCTYTIRVPRVWLRERERGLICAERYLWGSGIYTDDSDPVAAAIHSGFIRAVHPPGIDEALLEKVIEEQNPTIEGSPAPDKPKAVDENKDLHITLVVLPQLERYAGSARFGVRSRSWPEEQQGTDGSSPGSKAPHDGVSFMVLKCEAVDDGAEVKRVGRTGKEKRERLHRELVERQRTIQLEKEKLARIAGKLKERKEESKRPKKAGATGMEKNSSNLGKDVTSRAVADDQENLVKGKDEKAGDLDVGQSPGDWIRQLAVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZK2</accession>
    <name>A0A0D2BZK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236990.1">
        <property type="nucleotide sequence ID" value="XM_016378313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZK2"/>
    <dbReference type="STRING" id="91928.A0A0D2BZK2"/>
    <dbReference type="GeneID" id="27331047"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03964"/>
    <dbReference type="HOGENOM" id="CLU_046006_1_0_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF19">
        <property type="entry name" value="LYASE (GLO1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="38"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="247" mass="27097" checksum="D51CC2DD3558B2C0" modified="2015-04-29" version="1">MTETTCTSSTEPEAGKLVIGGHYPNPPLPEDDVTVGNKFNHTMLRIRDPTKSLHFYRDLMGMRTIFTINGGPFTNYYLGFPHTAEHRKDLGAFSAETAKNLPFTPGLLELKHIHGAEKMPEDYYSNGNTPPSLGFGHLGFTVANVPETVQRLEAAGIKVFKPLGVANRASIPLSDWEAERGVGVGDEDSIHDGYKQILRRIAFVHDPVSQSPSPALRIPRVVNSSAVALDPTRLQMLPRRLDDGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0L3</accession>
    <name>A0A0D2C0L3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237420.1">
        <property type="nucleotide sequence ID" value="XM_016378743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0L3"/>
    <dbReference type="STRING" id="91928.A0A0D2C0L3"/>
    <dbReference type="GeneID" id="27331478"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04395"/>
    <dbReference type="HOGENOM" id="CLU_024465_0_0_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="520" mass="57847" checksum="3C19D2B21F1A0DC2" modified="2015-04-29" version="1">MTAARLSPAASLLRNSKLFALPTALSVPPTEPTSEPVVSSDTATTPYPLRAALETPRSTLFKGDWGLKRALPVSTTTKSGTPTVRILRGIDTPEHVADFESAADHVLTLRKYQELNLRVTLPATRDKRHYERTSAFDPEIDHTAEVPLTLKGKNGPVSWLDKSPAERAAELPKHLRDTLEKATKDNPESNSASATSESSLSPARLSRRRWRYLGPYLAGLNGAEFEAFLGQITRAKKAEFRKHVERHLINQRIAQRRAEALESGETGETGPADDTSVKVTEEDVDEHLRQLRSEPSKFAPLIVEFFDLADGPKTSVMNREPWHYGRDTIAADQYKESGPPRTHPSAGLSYLRSESFAQNDVIVGPRDTRPPVPARLLKTIQIGQQRSIPNVGMAGFVIPQPHWSELRDRPWQWQSVKDGPKLVVQPVSAAVSQSGKVEINTKLMKDWYLEDDVPVEITERRRAGTNTTRPAPATQVRPLDRLFKRQSTVARSTPAPSQDISEELNEMTRRATQNLANRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3A5</accession>
    <name>A0A0D2C3A5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238300.1">
        <property type="nucleotide sequence ID" value="XM_016376730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3A5"/>
    <dbReference type="GeneID" id="27329454"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02371"/>
    <dbReference type="HOGENOM" id="CLU_120625_1_0_1"/>
    <dbReference type="OrthoDB" id="2559326at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031833">
        <property type="entry name" value="DUF4748"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15932">
        <property type="entry name" value="DUF4748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="128" mass="14198" checksum="D2AD780E8B112546" modified="2015-04-29" version="1">MNTIRSTWYGWGVLCVAGGGAYYFAKKSINADRAARFEAEQKQKAYQRRIEDSSYAPPRKTRTRTQADPSSGTHNAKGLDHAGSPSSEISEDVAPVGHAPVDSEQRIREKSKYEAAVPYRSKKGDRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C5F1</accession>
    <name>A0A0D2C5F1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239035.1">
        <property type="nucleotide sequence ID" value="XM_016377465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C5F1"/>
    <dbReference type="STRING" id="91928.A0A0D2C5F1"/>
    <dbReference type="GeneID" id="27330191"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03108"/>
    <dbReference type="HOGENOM" id="CLU_823871_0_0_1"/>
    <dbReference type="OrthoDB" id="3254104at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="333" mass="36956" checksum="2E9F85FF8EE0635F" modified="2015-04-29" version="1">MQKQYVQMRETAFDLYTERDALPWYYRACALTSSCSCLAGYIIFALVFTSDESNVKVSRTALIVLASIFLIAGYASASAIAFFGRSLLFFYDGVLIPILTSSFMGIVVTVLNHALHKDFPIPNHAYIYIPLVTACTTTVASAALTFVIYKRLAKMKRLDNHRRQRIRKFDRHSSMSYGDAASTTELLPIDPSIPEDEAQRRQLLRLLLNREAAEQSSPSPGMPSSESTYKIFLPGDEGFGGTQVVPASARPRSGSLPNSSTSAKWNLLAKITGDHSPPVESSFKDHRQRRREEIERSSILMPAGTDSPWLQPFSAASPSPSHSLSWSRSARYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C730</accession>
    <name>A0A0D2C730_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239590.1">
        <property type="nucleotide sequence ID" value="XM_016378020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C730"/>
    <dbReference type="STRING" id="91928.A0A0D2C730"/>
    <dbReference type="GeneID" id="27330752"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03669"/>
    <dbReference type="HOGENOM" id="CLU_046582_4_0_1"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="7"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="311" mass="34846" checksum="D9D2E9BF7A257CAC" modified="2015-04-29" version="1">MGLTPVHFFSHGSTRMLEAETESGDYWRKCGEEAIAHGVKGVVLMGAHWACLGDKIEVATNPNPGKSPCPFVDPALYKDWKPNPDLAGAERCISMLANEGFNVGPNKDFEWIHDTYMVLIKMFPDASKCPPTTIVSMNARYDPWYHVKVGATLRPLRKEGYLLIGTGGAVHNLYRNYWTDMLLYRESLGQEKPPEPWALNFRQATEDVVTRNRGPALRKAMIRLMQHPAYREAQATDDHWMPALFAAGAAGDFEDEAESNILAAETWELRNMCNSQFTFGTYTATEGDIVSERKTIGMDRVPRPRMVAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C892</accession>
    <name>A0A0D2C892_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanuric acid amidohydrolase</fullName>
            <shortName evidence="3">CAH</shortName>
            <ecNumber evidence="3">3.5.2.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the hydrolysis of cyanuric acid, an intermediate formed during catabolism of s-triazine based compounds in herbicides such as atrazine and polymers such as melamine. Catalyzes the hydrolytic opening of the s-triazine ring of cyanuric acid (2,4,6-trihydroxy-s-triazine) to yield carbon dioxide and carboxybiuret, which spontaneously decarboxylates to biuret.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanurate + H2O = 1-carboxybiuret + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70363"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:38028"/>
            <dbReference type="ChEBI" id="CHEBI:142864"/>
            <dbReference type="EC" id="3.5.2.15"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">Inhibited by barbituric acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Xenobiotic degradation; atrazine degradation; biuret from cyanurate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The monomer structure is formed from three repeating units (RUs) that share the same structure as one another. The monomer, the active site and substrate all possess threefold rotational symmetry, to the extent that the active site possesses three potential Ser-Lys catalytic dyads. It is possible that any or all of the three active-site serines may act as nucleophile (albeit only one can do so per catalytic cycle).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cyclic amide hydrolase (CyAH) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.15" evidence="3"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240010.1">
        <property type="nucleotide sequence ID" value="XM_016374734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C892"/>
    <dbReference type="GeneID" id="27327452"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00369"/>
    <dbReference type="HOGENOM" id="CLU_808206_0_0_1"/>
    <dbReference type="OrthoDB" id="5210206at2759"/>
    <dbReference type="UniPathway" id="UPA00008">
        <property type="reaction ID" value="UER00502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018753">
        <property type="term" value="F:cyanuric acid amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019381">
        <property type="term" value="P:atrazine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.160">
        <property type="entry name" value="Cyanuric acid hydrolase/Barbituras, RU C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.170">
        <property type="entry name" value="Cyanuric acid hydrolase/Barbiturase, RU A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.180">
        <property type="entry name" value="Cyanuric acid hydrolase/Barbiturase, RU B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01989">
        <property type="entry name" value="Cyc_amidohydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014086">
        <property type="entry name" value="AtzD/Barbiturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043008">
        <property type="entry name" value="AtzD/Barbiturase_RUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043006">
        <property type="entry name" value="AtzD/Barbiturase_RUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043007">
        <property type="entry name" value="AtzD/Barbiturase_RUC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02714">
        <property type="entry name" value="amido_AtzD_TrzD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09663">
        <property type="entry name" value="Amido_AtzD_TrzD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="RU A" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="RU C" evidence="3">
        <location>
            <begin position="253"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="337"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="376" mass="39161" checksum="9D863BF712A9B549" modified="2015-04-29" version="1">MVAVDILKFPISSPADTTPLDRLVESGYKSSQILAVVGKTEGNGCVNDFSRTLASTVWEPKVPADAVTIFSGGTEGVLCPHVTFIVRAEDTSSNNPSYTGLVASVGHTRALHPHEIGTPDHARTVAATIESMMADDLSVRPEDVVLVLIKCPLLTSAKVEAVRATGKEPITTDTYESMARSRYACAVGIAAALGEIPNTQIDSALQPAKASGSGSVWSAKASCSSGAELEDNHIMILAKDLAVSDVGSTGPQLRAVSRPMKDAIDADAILDLLSQVKQDGGKVVQVFAKAEADPYGTVRGNRHTMNTDSDIHSTRHARAAVGGLLAGLVGDTLLYVSGGAEGQGPAGGGSLCVVYTIRSEATSHEQSLPDRELSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CAS9</accession>
    <name>A0A0D2CAS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240900.1">
        <property type="nucleotide sequence ID" value="XM_016375624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CAS9"/>
    <dbReference type="STRING" id="91928.A0A0D2CAS9"/>
    <dbReference type="GeneID" id="27328344"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01261"/>
    <dbReference type="HOGENOM" id="CLU_028035_0_1_1"/>
    <dbReference type="OrthoDB" id="5078320at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF2">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="2">
        <location>
            <begin position="4"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="408" mass="44513" checksum="75DFF740964D98F8" modified="2015-04-29" version="1">MMKKKSVYANITPIPSHVPRQLAIDMLHSHGEIIELNPLVIGYRPIKAPQSAPADEYFSTWYEIDQRIQFVPGIGKAGAGKISFKGCFHDMPWGLQTHVYPPMGIEIRNKWQIRGNQPGEPPEPKELGSGAPAEGLYLREDIEITCNRAMMQFTKNGMKEASKVMVERLVRKAELIDSGVLSAMMEDGKLKTLNPADRSHTFQQSGQYSPGLMSPATAQFGPRSPGLPPSMDRNYLQSPNTPAYGRNSQYYGGYAHDPRQFQNASHLPPPQGLAIEMEGSVQFAPQQHQNQNLQPPHRFSTAASELSASSPPANQTLFPNSNASDRQSYAGSVSSHPTSYDPDGSMASPGLDKRSFAVELPGHDNAASNRSMTPQGGTSPDPNGAGFAGGGTPGQQYRYNPVEYARMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CC89</accession>
    <name>A0A0D2CC89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241310.1">
        <property type="nucleotide sequence ID" value="XM_016376034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CC89"/>
    <dbReference type="STRING" id="91928.A0A0D2CC89"/>
    <dbReference type="GeneID" id="27328756"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01673"/>
    <dbReference type="HOGENOM" id="CLU_067676_7_0_1"/>
    <dbReference type="OrthoDB" id="4863010at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW21094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25899" checksum="E5F47ABAC913EA71" modified="2015-04-29" version="1">MASTRTDSTPPTANPLQGVPSHVVDLLTRLHDESLRQENALTRDDFKKATMEEVMRDKFIALDRDKAEFVYQLCRATGAETIVEAGTSFGVSTIYLALAASANASRTGRRARVIATEYEPTKAARAREYWAECGRTVTDAIDLREGDLRETLKTDLENVDLLLLDIWTPVALPTLKIVEPKMRYGAVVITDNTIGAARGYKDMLEYLRNPESCYINMTLPFSKGLEMSVYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCL7</accession>
    <name>A0A0D2CCL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241460.1">
        <property type="nucleotide sequence ID" value="XM_016376184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCL7"/>
    <dbReference type="STRING" id="91928.A0A0D2CCL7"/>
    <dbReference type="GeneID" id="27328907"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01824"/>
    <dbReference type="HOGENOM" id="CLU_008375_2_0_1"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="28"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="847" mass="94198" checksum="0FE54A575ADE608A" modified="2015-04-29" version="1">MEVDGFLNGHLHAAKSVTTASSTTVVSYDPGYVVLSFFTSLVGCLTTIELLQRRTSTRGLYNWFLLIASAITMGGIGIWAMHFVGNRAIVLDHGDSQRQILYNQGFTAASFFLPIAVLIFAFYLLGTPAKARQLHVAVAGILTGAAVCGMHYMGQLGVENYNCSYSPGNVVGAAIISVAASLISLSLFFRMRDKWSDLWWKRTLCACVLAMAVSGMHWTAAAGTMYHWKGDLAVHGDSRTRTSVVASCLSMGACIVLLVVIGIRGRRRHNARIRSQRLVLACAYFDDEGNLMITQDGLLPNTKITNHYVEKTFGEDELSRTHETFLWIFQASHQWKLFKDLIPGMKNDVETDPTMHKYRPGSTATTLPVDTSEISLNFARVFKELFCVAAQQLANTIHEPLEKVGVLFEEPMDTGAVYCPPQSPKGLRKMSLLSTYTMSNDVERGIVSKTFTRGKYLFLVREVNRTEAAKFASLGYRFASVQQIADSLANSMQVNRSDLVERMLRVRKSSARSFLPPPGTYLACFMLKPSMYKSFDLLVPTDKQNQLPLVTLQIPDLSPEQKNQLQSFDEMAISEILKALLNGGTARAIDQAFRWQLYNAFVKLVDFIGDYDTMMQAKFSAKEFCVCGQHGGRSSSTKNCTTCVFYTVRILRDIHASPTRKELTFVPLSFFSVQQQVHTDNMDNEVFAQTVEQQFGHLQKDAQKRGRSSTSGGRTSSVAELNGSRSESPKSPRSPTFISPFGRSAVSRRSDEATIVDYDRNWKDSSAIEMRRVRSCEGDSPTRSSQSPIGETKNWVSELFGLFQLKPEGWSASKPGGWGLNISVQNSVEIETQDRRKDSSNTVSTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y709</accession>
    <name>A0A0D1Y709_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230892.1">
        <property type="nucleotide sequence ID" value="XM_016385948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y709"/>
    <dbReference type="GeneID" id="27338723"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11640"/>
    <dbReference type="HOGENOM" id="CLU_174947_0_0_1"/>
    <dbReference type="OrthoDB" id="4159979at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="94" mass="10723" checksum="3745D7E0877A2245" modified="2015-04-29" version="1">MAQRMKSLNTQLRKKGLEIVQESNDPEFGPVYTITPKKPGITNSDLAYRLYYWGETAKWSATRRKAIEKATNRINRIKAQDAASRKESSESSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7N5</accession>
    <name>A0A0D1Y7N5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_10230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231147.1">
        <property type="nucleotide sequence ID" value="XM_016384545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7N5"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7N5"/>
    <dbReference type="GeneID" id="27337313"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10230"/>
    <dbReference type="HOGENOM" id="CLU_015772_0_0_1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF30">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="791"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW10931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="895" mass="98912" checksum="E7B9FBD0F292B926" modified="2015-04-29" version="1">MAPKNRSQTPRLSGPAEPTLPVLSQHTTTTFLSDPSNHHSRRGSRDSLRNISSAQLPTPDTVVSTRSPIVPDSPHSTLESSNSRRESVSTMRTSSISLDGPPTCTPTGRVSKAKKGKRVHACEFPGCGKVFTRAEHRRRHELNHNPEALFPCTRPGCRKAFHRLDLLQRHQERHDLENSAASPGQMSQTPQMSVSSEPPSSVMPAAVISSPQADRSAPRSSAGALSIGSLVHPQTDYGYSMGTPAFNGFGRQTIPFIPGFNSSDDSLFYTPESSQSPVSDYYGRYPHRQSISSSSSVAAFEPNGASPLISGTIPGPWAPSSAPPSILPSNMLDDGAYLPVSSPFLWTGAYTEADQSPADSSIPIPLSDLDGYEWSVIRGELSNSSGLLSGDSPTGVSDTIRWHCLDLYWQYFHPHFPVVHRPTFLPTKPSPLLASAMSAIGSQYDDRPDAKQYSLTLLEIATKLLRRRDSITSRSRLADLQTVFLLEVLSKYCSRRVEVEMSARFRSLFASLDQARRTLATDPLAVFRTLRKDKTSEDIARAHKFWLDHETRRRILQASTVLDHQQATLFEQQPTIVQHGRPRRTTSPSLRCNIPLPCSEELWETSPIESWVQLAANNDTSKPRSHRQDSSMGPPQDYFQNLVGMVACQGLPDQAPLRQERLADAAAYMAFNQHASEMARNTPIRQLLMTSGESWILGKKLENEAEFQDAKRTLRAWADSNFQSRIALWHATQLIRSRVKFSYSEPTRTELGVMFQDTHMLHEPWVLYLAALVCWAYGFSASTALDVNVQGSGAGSTTSNPQSNASRTPSSSASAHPALLDSHEAAYSMREYLQTTDVDKVDGILSIDPQIFGRTHGLLEAIRLNKIGSLLGGLMNEAERVLYRLVEGRSRLSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8N5</accession>
    <name>A0A0D1Y8N5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231572.1">
        <property type="nucleotide sequence ID" value="XM_016384970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y8N5"/>
    <dbReference type="STRING" id="91928.A0A0D1Y8N5"/>
    <dbReference type="GeneID" id="27337739"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10656"/>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_1"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="143"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="409" mass="44293" checksum="2439969548EA569E" modified="2015-04-29" version="1">MPHLKIAIIGAGPAGCLLAPYLIQGSIEVTIFEAEDSPTARSQGGTLDLHPNTGISAIEEAGLGVALSKLLRCGGSRLKVVDQRLQTYFYLPSALHNAPEIDREQLRTMLLASIPDQVIRWSHKLKEIPSPGVLTFDNGQSEADYNLIVGADGAWSQVRRALSNQLPVYSGVSGYDLNIPDAVNISPASSDLVGGGTIFAFANGKSIIGQQLGSGSISVSVWSRQGDGWMTDRREQSPLPADILDGYNDWAPELQTLVVDAIGPIRISALYMLPLGFRWDHKPGITLVGDAAHLCTPFGGEGVNLALRDAQKLGRAIIEASRDRDLVTNLDKRVAVYEADLFKTGHKAQVMAYDMMRAMYFTNGAPRAGIESWVIARAVYNTPQILVGVHHLLLAVGVYSLFFFIKLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDI1</accession>
    <name>A0A0D1YDI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233237.1">
        <property type="nucleotide sequence ID" value="XM_016382534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDI1"/>
    <dbReference type="STRING" id="91928.A0A0D1YDI1"/>
    <dbReference type="GeneID" id="27335291"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08208"/>
    <dbReference type="HOGENOM" id="CLU_412210_0_0_1"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF3">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="269"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW13021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="666" mass="74647" checksum="EFE99C6373C430DA" modified="2015-04-29" version="1">MERPVRPSQQQSQARNDSPHHGVLPPFRDLVQRGTVAVSPSRPNAQQETVALGGSSSGDTTPGSVVDSWRPPNGNLERFDAFLGNHSDTYAPLFVDQLPQALAKTPAYGATGSSLESASLSRDHVPTVVSPKTAAEHPDHLDAADIAFLKAKGAFDLPPTNLQRELVESYFKYINPASPVVNQTRFRADFDRGVVSRLLLFAVFTAGSKACQSPLLIDVRGTRLKSGQQYFKITKALLDTSYETDKLTQVQALLLMSWWWDKHDDGRNMRTYAIKAISVAQSLGMGRWIQYPTSDPVLCGLWKKVWWCCVIRDATTSTASRLPLFLRDSDWDVPLLSADDFVEDDGLSCSESEIQFFIQLAKLSEMLGMVLMKNYRRILAQDRDFAMELDRLQREWFDNVPEELQYDVDDTQRHRYWPAYLNIYFFTMICIDGLERSGLKTQTQGKEQASDQYWSQARGLAAASMVIKTIRNLKAHGQIGQCHGFMINSLLYCLIYCKIEAESPRSEVRAYARQKYSICLNALYDFGQLWVSASYLHTVFEALQPAMNGSNQKPGPNSLFDQGDMQPWPSEVKSSAEIGNSVMRIILAAERPSGPLQLHDKDHDGVSPPDRQLTDTNLHPVSLDTLLQNDLSSFSPDLFGYNGNFSVDTMDTENWYGFLNMGGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YE32</accession>
    <name>A0A0D1YE32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233567.1">
        <property type="nucleotide sequence ID" value="XM_016382864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YE32"/>
    <dbReference type="STRING" id="91928.A0A0D1YE32"/>
    <dbReference type="GeneID" id="27335622"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08539"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="336" mass="36847" checksum="E7E3B6A2A9BC4317" modified="2015-04-29" version="1">MKVLLTGGSGFIGTHILKELLNHGHETVVTVRSAAKGSFLVNKFRSSGNVSFVVVEDVAAPNAFDQAMQSTPAFDGIIHSASPFHFNIRDAKKDILDPAINGTTNVLTAAAEYAPFVKRVVITSSLGAMLSMPNHPDEYNETVWNPTTMEQALNDFALTYNASKKFAELAAWDFLRDKKPAFSLATINPPFVFGPVIHDLRSLDNINTSNGRILSAANGGFRDKIPPTGSFMWVDVRDVALAHVRALERPDAGGHRFLLVSSFWTNKDLVETIGVQFPGLKANLPREIKSDMPDEMFTFEIEPSRSILGLQYIRFEKSVVDTVNSLLAIDPSLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YGT3</accession>
    <name>A0A0D1YGT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234422.1">
        <property type="nucleotide sequence ID" value="XM_016381320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YGT3"/>
    <dbReference type="STRING" id="91928.A0A0D1YGT3"/>
    <dbReference type="GeneID" id="27334070"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06987"/>
    <dbReference type="HOGENOM" id="CLU_004894_0_0_1"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF3">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="334"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113167" checksum="AA6294F42065D9CF" modified="2015-04-29" version="1">MSKPVNHQEQHCTILPSSPRLPILKDLHDRHDRNAEPFMTHEIKSSLPLLSTDSPPSSDDMVFSLSPVLYPPSSSPAPPVQPPAKKRRLFQPFPTELQRKRPKVVGGFFEDSDVEEDQNEDEDENVSIRTDPETVEHATEQQPPGVPEVPDSASDRAHHGPSSTPSLPPLPRPLLRRLPPKTLNVRTASGANVDVPLRQKTEAVSYERTIAQRSTTVAGRSRRSYYGVEIHKLVDEARTQRQLDDFEKQRQAEQVATTPSVETPPLGRRSDSVAYQMWTEKYRAKKFTDLVGDERTHRAVLRWLKSWDDLVFPGHSRPKPTKIYEDRDVTEQQHRKVLLLTGPPGLGKTTLAHVCAKQAGYEVLEINASDDRSRDIVKGRIKDTLGTETVRGIKEHGKARKAGRPVCVVVDEVDGVTAGSSSNGGEGGFVKALIDLVQLDQRNSSQTGNQTSAAGKKRKGDKFRMLRPLILVCNDVYAPSLRLLRTSSIAEIVHVRKAPIDKVITRMKAVFEKESIACENDAVRRLCENAWGLAMRKQRGLGTRASGEGDIRGVLVQAEWIAHKLRANGSKTKLTRKWLEPQLENAQAGQKGLGRGGVREIVERVFIEGAGLPDLPASLSADDKRLVAESKTSPVGVADLRKRAAIAALREMVDTSGDHDRVMAECFATYPNQVYQDDVQLSKPNASYDWLHFHDCLSSRVYSGQEWELTPYLSTSACAFHHLFAAVDKGSKAWNDDKPDEEQVDAHPFSGDKADFAAYEAEKQNRTLLTELQSSFSGSLLRLFSSVDTIATELIPNVGKMLAPDVKPVVIGGSGGSASVASVRKDTEKMCIKNAVRTMMALGLSFEKVRVEIEGGGAHSNGGYAYRMEPPLDTLLTYHLDGKVAPVRYAVRQVLDQELVKEKILQNSAARHARAGAPSHLGMTVEADKENMATSEKVGGTTPTKNPGAKRDFFGRVILESAHVQNETWLPSSDGGRKSLSSGTGRKGLTTMTTKEQGARIWVSFHEGFSNAVRKPITLKEFLDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKV9</accession>
    <name>A0A0D1YKV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235872.1">
        <property type="nucleotide sequence ID" value="XM_016380045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKV9"/>
    <dbReference type="STRING" id="91928.A0A0D1YKV9"/>
    <dbReference type="GeneID" id="27332788"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05705"/>
    <dbReference type="HOGENOM" id="CLU_485737_0_0_1"/>
    <dbReference type="OrthoDB" id="5303703at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="62301" checksum="402FEC0D969566D2" modified="2015-04-29" version="1">MASLTPYEDERRAKTPDYDDCGFYSKTRFVHILDLFREGQARDLALKSPSKTPISASTYDLRRRVCSYAHFAVGYEDKSSSDDDYDPATENRRRPVRNTGRAGGNQRSPRGTNQNGGGVDTDVGGLRKRQKIVPPRLQPGSSKEAPRKLATQQSSQGRSEIPGQVEQSGGGGDLVSPDSSQGRSIRPRGEPRDSYLGKLDEESAGIDNANGRALRNRTIPDQEQTQHEKGAKCAGCHAARKKCIWTIGHTCARCKRQDIECVKWTDDSPIETTPTNDASFTIPSMADDNMETKTEQGVSTQTSPLMNPQHVEASVPMNSRTSPDPSQLPIGSSANPIVLDSPPDSPLLSASPASIRQIVTHWAHPIDFKHVKNAGPCHFCTDFRFGVFGHGRITTKVIQYPGSTALEEIGDGHRSNGKEPTRMCVICALRRIYISKCTVHRFKHMDNQAGVQKSILYAQQLRAEVWDPPVDSTAYSTCKICPELADWRCCVDKTVGITGDPLRDGRGPGRGCGLQLCNTCKLQVEGCGGVLEKDRIMKADGKELRADVEFLFEESLLHRAYFPPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKY5</accession>
    <name>A0A0D1YKY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235907.1">
        <property type="nucleotide sequence ID" value="XM_016380080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKY5"/>
    <dbReference type="GeneID" id="27332824"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05741"/>
    <dbReference type="HOGENOM" id="CLU_029043_0_1_1"/>
    <dbReference type="OrthoDB" id="5412502at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="532" mass="59831" checksum="92E82FA0246F83BA" modified="2015-04-29" version="1">MHWIDSFDDLQLDIVGIIAVLGEASVTRNAQVTSLSWWSAIPRLLPAPQALLEHERKSRLPTAPGIVAGAYSGNIKKEINFFAQLVHPRQLEEYEVELVEVTRRKEAKDAFGAQTFGPLLWVSLLGFSMSIALVVLSVIYHDGFALLATIMLSMVSCAVGFGTRWELVFAEPEIKKERENKMPRSDVLIYYPNGAIRVIRPAYEEIARLYFQTEHARYKIDDTPYRTLALFSTIMLIAGVVSLANASNKLQVSFTAAYVLLNVLYWGVSALNPCRFHWKHAYQTRVLDIAPLPGPHDKALDYKGVVKRSVRQLRHDWHHFQRSWGLVEPARISRTFVDPEIGARTFTAALWTAIVLTGTAQWLNEATAIAPVNGAWKAWITEADSKVEPIDLFEGRHQPHRTSALPRQGTNWRQTRFQTGPDARDKRRIIIRDKIRDWKYDERLTSILAEHANKTRKPYPDETDETVEITPEKHDVAISIDGSSAASGERLATARLSRRIDSGAGISGTTITAGVEVVDMLTQSSEVEKGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSB5</accession>
    <name>A0A0D1YSB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238347.1">
        <property type="nucleotide sequence ID" value="XM_016376777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YSB5"/>
    <dbReference type="GeneID" id="27329502"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02419"/>
    <dbReference type="HOGENOM" id="CLU_043410_0_1_1"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36506" checksum="6840F499644FE975" modified="2015-04-29" version="1">MLRSSIRQSLVTKVILRSISTTKLGGMNSAPVVVSPSKAEVQAGRLRERNLELAVRSVLQDGLVVIKDAINHDVLDKLNDKMKEDAVILRNAGENSPFNYNRGNLQQDAPPVRAHFEPTIFLNPLATQVTSSVLGPRPKLTFMSGNTAMPAAEGVEPQRQPVHADADFRHPSHPFALVINVGLVDMNPNNGSTELWLGTHATTSIDDQEGAHGERASGRIKEASLERRRAVSPPMQPTISKGSLVIRDLRLWHAGMPNLTAEVRIMLAMIHFAPWYRNQMRLELGEGVRSLVEAEKDLDIRADFIPEQEAMKRYLNRGFGNSYDFNQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YTN0</accession>
    <name>A0A0D1YTN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_02874</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238802.1">
        <property type="nucleotide sequence ID" value="XM_016377232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YTN0"/>
    <dbReference type="STRING" id="91928.A0A0D1YTN0"/>
    <dbReference type="GeneID" id="27329957"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02874"/>
    <dbReference type="HOGENOM" id="CLU_004329_1_1_1"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000206">
        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="290"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="817"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="993"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1057"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1158"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="827"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="995"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1061"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1163"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1193"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1246"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW18586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1269" mass="139236" checksum="7196BB648BAE4556" modified="2015-04-29" version="1">MSDNVGITWAPNLEQPRHSQGAATATGGLNVHHKSGNDGRQDQWGDRENHDERDSGTQGNTPIALVAQDPLETVEEDHGHELDAQALPGLAASPAFGPPRPERSLPSSTQTSSNSLKALSLLESDRGFGSGVSMVQRKLSTRSSQSQIRGRRLSHSKSLSSSHPRLSGITADHPKYPDQSFAALQAQFNGQRPHPPLRTRSSHPAQNLVYNEMSTWRPSKERHPGAHGTKTADNTPMSSPGLFNPDARVPSASSLTDLSPHLHHLQTPKETHTVEIEHDTFSGNKFINNYEIVQELGRGEHGKVKLGRDIEKGTLIAIKIVPRYSAKRRLGRLGAPEDRTKREVAILKKARHPNVVSLLEVIDDPSKNKVYLILEYVEKGEIKWRKPGVREVLAVNNNRFSQERVGIDVPIEPTERDLYIVAQAARRHEQQERSRLSNLQSIPNWSLEYGGEEEDEDEFSDISRSASRHFYAGSSNPSRTNSHEDYHADSALAGSMYGAYVPETYRPRKFSIATSAISHMSSEVNFEEIDDEHSFVPALTLEEARRAFRDTLAGLEFLHFIGIIHRDIKPANLLVSATGTVKISDFGVSYLGRPTTEEDPENRLTEKDVSALDDEKELARSVGTPAFWAPELCYEDASMFEEKNGPRITGALDLWALGITLYCMVYARLPFYANDEMGLHEAVCRAEVFCPKSRLVPVDTSRDKPTSYVPSSINCNKRLDYELKFEPVPDGVRDLIRKLLVKDPAKRMTMEEAKTHEWVVEGMPDPNQWIKGPMEMAKESKKKILEVDEREISHAVGKRNIIERALNTAGRIAGSLLGRSNTRRRAPSAATSASHSSESIASPSSTSTVGRGDRENKIKDGRRSSLRGDEVLAALKTSRDNGEHPLAQSQTASPDDSPRETYFTSSLKGLDAPSTLSSTVPEREGRPRGPDRAISTMSTAESVKTIRASQMQRLLLPHAETAPELERPFAAGERSFKAMVDGLWEGTSKTLVRLGSRDRRSQHLDRSPAPSRHSSDGDGHAGPSLAISTASASGAIEQPEALKTVMSPVEYHTAPPASAALSISRTNTKISPPTSSQEAFEHAQEVNQRRHIQEVHSRAEAATAAASRAQSENVADECAPSPDDIAFLERQRTRVANEAPPISIEAGPSASTIASSLEDYGNSSVSQSMSNPSFGVTSNASSPPGEGYYHGESASNHQTTPATGKDLEPDFMRTADTIIKHGRPQQTATAPSLEDWATQSYQNNDGDYDDSDDDGMVMMKGSIVPKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YW60</accession>
    <name>A0A0D1YW60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239707.1">
        <property type="nucleotide sequence ID" value="XM_016374431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YW60"/>
    <dbReference type="STRING" id="91928.A0A0D1YW60"/>
    <dbReference type="GeneID" id="27327146"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00063"/>
    <dbReference type="HOGENOM" id="CLU_023303_2_1_1"/>
    <dbReference type="OrthoDB" id="3433125at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053221">
        <property type="entry name" value="Burnettramic_acid_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="439" mass="48926" checksum="34CB603BD6128F39" modified="2015-04-29" version="1">MDTSHDGLNPVDDELDSSTDSQDEVEPQQSGESLLNTFIQAHSQPSTSTTHLQAAKSRLPYPVIITQRRPGHKRRGFIKAYAPVLEQYGIDQDTFIEFIRATNKAMEENKLLVAVQLAAAGTGFVPNHIALGVSIAVQFIAGAIAQAEAKWRTNSFLDRINDEFFRPRGLFCLLMCYNPIALEKKDAPEEIDAVSKAISPSLKPSFGGRARRNLRDPVAATVEGEENLPANTAPLVYLEKTESEDPHSDANSREKQNIGDRLNKYFDKRAQARYAKESNGDILSNPEPVKFKNRYLDPTSAASNGGLLGLVSGGKLTRDPEKTKQSIQAQFEAQERAIQEQQSIVMAGLQQQLQAMSLSPAQQQQYIKQYQDIYEGQLQQVRQQSDLFTKGKLHRRIDVLYLMIVDMPSDEEMETARTQLRTSGQTRATNKVKFATVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWL0</accession>
    <name>A0A0D1YWL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239907.1">
        <property type="nucleotide sequence ID" value="XM_016374631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWL0"/>
    <dbReference type="STRING" id="91928.A0A0D1YWL0"/>
    <dbReference type="GeneID" id="27327348"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00265"/>
    <dbReference type="HOGENOM" id="CLU_073901_1_0_1"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="8">
        <location>
            <begin position="85"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="193" mass="21973" checksum="8A46E6798AF963D0" modified="2015-04-29" version="1">MFILTKFEDLVQIPPHGFTNNQITSKDLEDRINEKYSNKVVQKTGLCICMYDLLKASDGLIGTGTGNANVNVTFRMIVFRPFKGEIITGTVQKCTPTGIRITTQFFDDIFVPQTMLFEGCHFDEAEKTWVWRTEESELWFDEGTVVNLRIEAEKWHDLAPKGPNEVEKEGERKVPYAIEASMAEAGLGGVEWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YY21</accession>
    <name>A0A0D1YY21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_00751</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240392.1">
        <property type="nucleotide sequence ID" value="XM_016375116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YY21"/>
    <dbReference type="STRING" id="91928.A0A0D1YY21"/>
    <dbReference type="GeneID" id="27327834"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00751"/>
    <dbReference type="HOGENOM" id="CLU_042307_0_1_1"/>
    <dbReference type="OrthoDB" id="9975959at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09080">
        <property type="entry name" value="TDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="12">
        <location>
            <begin position="65"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW20176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="339" mass="37773" checksum="8A1AD176E52612D2" modified="2015-04-29" version="1">MDPKLKRMIELIESKKKPSHPWKREERHSQPYYTFSPSTSSWDAVTPAPSRPSDSPSTPNTFTLVSWNIDFMLPYPDERMAAALNHLQSLTTQTSNPTVILLQEMLESDLSLIQAQAWVRSGYHMTDVANTHWESGHYGTVILSPKALPVTAVFRVHYEATAMERDGLFVDLDIQGRTVRICNTHLESLVADPPKRPLQVATAARHMHDPGVAASVLAGDLNAIQPFDKTLHSDNDLQDAYLALGGQEDSDDGYTWGQQAPTKLRNMFGCSRMDKVYFCGAVECTRFERVGAGVTADEQHVRDGLVQEEDMDQGWVTDHLGVLADFTVLPAGPRSEPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYK2</accession>
    <name>A0A0D1YYK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240582.1">
        <property type="nucleotide sequence ID" value="XM_016375306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYK2"/>
    <dbReference type="STRING" id="91928.A0A0D1YYK2"/>
    <dbReference type="GeneID" id="27328024"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00941"/>
    <dbReference type="HOGENOM" id="CLU_056572_0_1_1"/>
    <dbReference type="OrthoDB" id="4158841at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17242">
        <property type="entry name" value="DUF5315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="301" mass="32513" checksum="A56FC74F4BC7C37A" modified="2015-04-29" version="1">MTSSARKPSLLEVPASPLERPKSNFTRTNTHRLPPPSLFQGPPSKNASHGSLSLPGAGGGSGSGGDRSGPEPDLPHRINRPSRVPAAASFSGPSMRQPPTQPDLRRAENLWAEMQKTLADVEVSALNTSHVFGASHIKALEDLRMAQHSLAQTWAKTEADELHDVEHEGVTDNDDAAATIGGKVETSSTTNNKNKNNKGNANAAFTNNKNLEEETERDIQLARRRREANDRYFEQVNRGVLDVVNKLDEVAGAMRRVERESREIWDESSDDDMSGSETGSVTDHTGVTDSPLHATAGKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZC9</accession>
    <name>A0A0D1YZC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240872.1">
        <property type="nucleotide sequence ID" value="XM_016375596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZC9"/>
    <dbReference type="GeneID" id="27328316"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01233"/>
    <dbReference type="HOGENOM" id="CLU_2573909_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="81" mass="9323" checksum="FEB3D137C1E4E7F8" modified="2015-04-29" version="1">MSALRKKLQSLNKQWVAIEQKLKYNLKRHELEVGVQQRQLAEASNQLAQASYHLAKSNRNVSNIIMVSRSTEIMLADEIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z042</accession>
    <name>A0A0D1Z042_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_01505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241142.1">
        <property type="nucleotide sequence ID" value="XM_016375866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z042"/>
    <dbReference type="GeneID" id="27328588"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01505"/>
    <dbReference type="HOGENOM" id="CLU_1384185_0_0_1"/>
    <dbReference type="OrthoDB" id="4118192at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW20926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="224" mass="24894" checksum="5C5DC1C17BBFD8B3" modified="2015-04-29" version="1">MAIFERIHLLQSILLPRPRTNPAWQKAKMRFSFTATALLFGRLTLVSALPRVHVWMESQEQYDDSSDICDAADDTCSWRPPHLSHLQGAAMDELDLREGYFLDDQEANESNEAVVIVIHTPTRTSKNTVATAASPCHLRMVTSAQLQLQPRNAVPEPLEQVADIPKSIQQEESEAPVTVTTAPAPLVACGRWGSCPDGYDWFPFFQGCFCELKLTKTISVPNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z1N1</accession>
    <name>A0A0D1Z1N1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241762.1">
        <property type="nucleotide sequence ID" value="XM_016376486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z1N1"/>
    <dbReference type="STRING" id="91928.A0A0D1Z1N1"/>
    <dbReference type="GeneID" id="27329209"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02126"/>
    <dbReference type="HOGENOM" id="CLU_009665_9_3_1"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF7">
        <property type="entry name" value="P-HYDROXYBENZOATE-M-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="414"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="72548" checksum="E2DE6BF818682731" modified="2015-04-29" version="1">MPEVPLYDVVIIGAGPVGLLLSVALSRWGYKVRHIDNRPVPTATGRADGIQPRSIEILKNMGLKRKIMAHNPARVFEVAFWDPAAGGKIVRTGTWASCPDFLDARYPFTALLHQGLIERVLIEDIEKNGTHVQRPWTITRFETNNVNPEYPVEVDLKNLDSNVTETVRAKYLFSGEGARSFVRDTLGVQIRHKDPISHVWGVMDGVVRTNFPDIKMKCTIHSDHGSIMVIPRENNMVRLYIQIASSTDPDFSPRKTATVEEVQAAAKRIFQPYYCTWDRVEWYSVYPIGQGIADKYTLDHRVFMGGDVCHTHSPKAGQGMNTAFHDAINFAWKMHLVEAGFAKRDILTTYEVERKFIAETLLNFDNKYAALFSQRQPTANEVDSAHNSHGGHDTKNEFVEMFKANCEFTSGFGVAYNPNIFNHSSEHSFQHPLIIKDSPKLRPGRIMPPSNVTRVVDANVVHLENEIPFNGAFRLFVYGGASQSPKRGQHKALSDLASGLTSPGSFYTRYESKERQRDNHHDSDNPHSRFFSIALTLVAKRSEIEISDLPAVFQDYSGRIYADDRKDIRVLDAKASAHAKVGLTGSEGAVVVVRPDGHVGVSVRLVEGQGTVEALEGYFAGFLNGTYDKDGRSRSRTGLGGGSEHVRAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z9X2</accession>
    <name>A0A0D1Z9X2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230033.1">
        <property type="nucleotide sequence ID" value="XM_016386225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z9X2"/>
    <dbReference type="GeneID" id="27339001"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11918"/>
    <dbReference type="HOGENOM" id="CLU_354126_0_0_1"/>
    <dbReference type="OrthoDB" id="4151037at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="793" mass="88045" checksum="8CD9E0BD85E59E0F" modified="2015-04-29" version="1">MPGKYSHTVVLATYSSRGIFNVPSSQRSNPERDDLSGTSYSPFLKSRNGESPPAKKTSATTPSQSTPDHPRRHPRKDSSRKSTQPSNNTSSHTPRDSHNHPSGVAAQTHGVSSHGQESRPRQAEAGIESSSKPEYGLSRYSHYESDPWFIPSRQSHQIGTDAAERAIADPSEPYAMPQHRHVRKYEPRPDVSERRGLMPRSRHYRSAKAEKHVEPLLSLQQFLDLLPPRDGSSSQLDRTPPQSVFLSSSKRVTLLPGFRPAPPRCDSAPALHRRSSHLDSARPPPRTANSSDSFNRGDTSFIDSSDDSEEGEEVTGFEKLHAAHMPPSTPAGHDDFQPPFSGYHEDANSRRKIVDLTKDLRELPAMYSPRPENGANSPPVTVTKVHQMQSERSSLYPYESDVSEDFPLQKHSPPPQLRSATFQAAHLTRSQTPIYELPDNQVERIVDGLRKGPLSSDPKTQKLNVAAEERLPPLPEFSDIDDFEENPNTPSVIDPPHGRQRYYRTKGEETTKSESRISISRLTSRKSFDIGRRASLSSAIYAQGRTPSRIAGTPEPLHCDMSISSATDIPEVAPLRIRSKTPPVPTRDSRRVTSPTACPGPTIPFRPVNPTPNFGTLSVVRNPDEKTMLKVQNVSRSTTPLPAEGKASPQKFPLLQRHLLHSFSDLASMKSINVPELTRRSSYESLVSPERKGMSPEAKTPSTADFADDSWGRLSIEPARSTRRVAEFESQPAQSHDNVEKRGRSNDINHQRGPVALPPPDIYRHRPGEVQRGAVAVGGRNQSKGVFGRFIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZA32</accession>
    <name>A0A0D1ZA32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_11983</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230098.1">
        <property type="nucleotide sequence ID" value="XM_016386290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZA32"/>
    <dbReference type="STRING" id="91928.A0A0D1ZA32"/>
    <dbReference type="GeneID" id="27339066"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11983"/>
    <dbReference type="HOGENOM" id="CLU_048602_1_0_1"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW09882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="321" mass="34979" checksum="F20C2B1ABA2D57C0" modified="2015-04-29" version="1">MGWWKADPVPEPPQQQTTPSTSSIPQPPPPAPPSNSGASASACPVDPQTRSIWLQQAQAQKNKNTQSQSQLPPSHPPLPPHHPQVEASSQPPLLPTAYASSKECSSDRISQDPSPPLTSAYKTSRPLSQDRAISSIPRSQTPTASSSSSSAAPANAETETGHHSSGNWIYPSESQFFNAVMRKETLTSSNPEDLLSSISHIIPIHNAVNERAWSLIKTWEADSSSACGGPKLQSFRGLGAGALSPRARMKSLMGYTQPFDRHDWVVERCDGGTVEYIIDFYQGKPDPNGKPNSLNFYLDVRPKLNTLEGCKMRAERFMGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZDC0</accession>
    <name>A0A0D1ZDC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231183.1">
        <property type="nucleotide sequence ID" value="XM_016384581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZDC0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZDC0"/>
    <dbReference type="GeneID" id="27337349"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10266"/>
    <dbReference type="HOGENOM" id="CLU_016204_0_0_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="958"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1078" mass="117495" checksum="7EE674FB5655E1EF" modified="2015-04-29" version="1">MKPDVPPSYENAISREAWPIIAPYIPSSDLCSACLVSRKWYSIFVPFLWGDPASHFGIANDAVYVALTRFKRTLRKARPSVRSLTHTLHLPPALSEIYGGPNPTWLRDVLEYLPNLQSLIVAKLPFFDHHSLNALRVASNGRKQSAAEDDELPPYGLKLLLASSEPNTTSSALAGALPRFQSLVYLDLSYTSPARDAAVLASLLWLRDLQVLKLRGVGLKDGEAEVLANAIGIKVRLLDIRDNLLTDMAVRSLMQACFLPSDTSNRGNLNLEDWPVGMAPGPNFFSLDTLRSEELDHELLKQLTKPLTGRLAFEDIPHRGLTHLYISGNRLSVEGLASLLKSERLHVLDGGSVDTVKTIARTKSLSSPTGYIDEVRFPGAEKLVPVLAKSASKNLTHLRVDHALVTAKLEGPHDSIKTKASSAVSAESATSQPVTAELSSEERHIAEAPASAHYAVELPDSQAIFELDATPAQPRVELVGDMMYFALSPPIGEKPQESSPVVEKHSPIRGEGPFAPEVVNEHDSKKENSAEDHGNATESEISDETGTHSTTRSLFSPVSPISNQGTYQPLVPPTAKAKSTPTTLPLVKESSDSISETPVAQPDATLAPPPTPTSHRQAQIEALLAKRPVQPSKLQQGLKVDQTAFSNLRSLHPSLLPNLRTLILTEVPTTTSKSSGVLENLKSFISACADESALARLLARTDYSLPPGRARYMAELEQARALFALRTIILEMEQPAAKNADAQRRWQHSRQDVTMSKSSTGDMDSENLWSAAANDFSFFGEEGEEHDECGIYEHDPEKYFPTAHFDDKIILTADDGHDDVRPNSPHGSLNQGWGTGSGTLSPFSMNLGGRSAGTIRSPRNLPLGRNRRSSNETRSRPHSGSGSGTWDPRGMLSEMQGGPVPPKLLNEHSQPAQRRIAPTTSHPKQVEQDNEPEEEKVDVIAELAAWRRERKKAYEEELARHKSSRLGHSRGPSQNGLTHVNGASTNTRLDSTDGPRGYGYGFDPGAVNAATGAGNLPMSNGSATPKAITHGDVNDIDMKFVEGHWKGEIKVIRNPTPKGRTGVVDMYGNYFEKGYLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZDJ0</accession>
    <name>A0A0D1ZDJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_10321</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231238.1">
        <property type="nucleotide sequence ID" value="XM_016384636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZDJ0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZDJ0"/>
    <dbReference type="GeneID" id="27337404"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10321"/>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_1"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="6"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="92"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW11022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="520" mass="57246" checksum="648D7611FC6EE5E1" modified="2015-04-29" version="1">MAKVDQKAVLIVIDGWGIPSETSPPEGDAIAAADTPVMDGFAKEGSSTAQGYTELEASSLAVGLPEGLMGNSEVGHLNIGAGRVVWQDSVRIGQTIKKGEMKDVPSVKNCFQRAIDGNGRLHFLGLVSDGGVHSHIDHLFALLQVAKEMKVPKIFIHFFGDGRDTDPKSAAGYLQQLLDKLQELGVGELATIVGRYYIMDRDKRWDRVEIGMKGVVLGEGEDSTDPLATIKERYDKGENDEFLKPIIVGGEDRRIKDGDTLFFFNYRSDRVREITQLLGDYDRSPKPDFPYPKDIEITTMTQYKTDYKFPIAFPPQHMGNVLAEWLGKKGIKQCHVAETEKYAHVTFFFNGGVERQFEGEEREMIPSPRVATYDLEPPMSAQKVADKLSERISDNKFEFLMNNFAPPDMVGHTGVYEAAIKGVTATDAAIGTVYETCKKEGYILFVTADHGNAEEMLNEEGKPKTSHTTNKVPFVMANAPEGWSLKKEGGVLGDVAPTVLAAMGIEQPEEMGGTSLLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHR8</accession>
    <name>A0A0D1ZHR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232663.1">
        <property type="nucleotide sequence ID" value="XM_016384040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHR8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZHR8"/>
    <dbReference type="GeneID" id="27336807"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09724"/>
    <dbReference type="HOGENOM" id="CLU_030571_1_0_1"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42091" checksum="9D5E10BDD983E74B" modified="2015-04-29" version="1">MAKDQANGTSNNAGVARIDLHIPPSVTSATVKIIDIASVNNVPSHALFTPTVKGIDVHNAPSFCFLIEHPSGQKVLFDLAIRKDWENLSPAITERLKMVGHRPVVEKNASELLDESGVGKERINAVIWRQAYSPGHAHWDHTGDMSTFPGHTDLVVGRGFKEHFLAGDGNSALGGILPSDVEGRAVREITFEESEVVRIGQFPAYDYFKDGSMYLLDSPGHCVGHLCALVRTSTSPDTFVFMGGDAAHHCGEFRPSQYLPLPDTISLQLPQHDRPVPFCPGAWYEDLQTSRNRDPKGPLWQPSFGHNMEEVMATVGHMQEYDGDDNVFVILAHDASLRAPNVPMFPDSINEWKSRGLGRDLRWTWIGEILSALEASGGRVPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZL86</accession>
    <name>A0A0D1ZL86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233788.1">
        <property type="nucleotide sequence ID" value="XM_016383085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZL86"/>
    <dbReference type="STRING" id="91928.A0A0D1ZL86"/>
    <dbReference type="GeneID" id="27335844"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08761"/>
    <dbReference type="HOGENOM" id="CLU_050461_0_0_1"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="288" mass="32174" checksum="1458F3B787E25862" modified="2015-04-29" version="1">MADFDPEKKYQKQEETFFDDGREIELLHFIYGNPDLENIRNSPSKVLAAIDVFARTKKYLMNVGEDKGRIVADLIAEVKPEVMVELGGYVGYSCILFGDAVRKAGGKRYFSLERNPEFAAVIASLVDLAGLSDIVKVIVGSSDVSIKRLHASGDLRHIDLMFLDHYKPAYTKDLKLCEELDLITPSSVLAADNVIKPGNPPYLEYVRSSVEQKKRATKLADTVNGVDSRFADKTTNQYLKREGQAQLDETRVGNPLLIYESKLINSFEPSGIPVGRPSVFNFLESPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQF3</accession>
    <name>A0A0D1ZQF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235208.1">
        <property type="nucleotide sequence ID" value="XM_016382106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQF3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZQF3"/>
    <dbReference type="GeneID" id="27334862"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07779"/>
    <dbReference type="HOGENOM" id="CLU_068979_8_0_1"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="202" mass="21984" checksum="C639527E844B940F" modified="2015-04-29" version="1">MVQLDSAPALVVVDMQNGFCHKQGSFAKMGMQSDPTAIVPHINRLRAAFHAADVPVFFVRTAYNADYSDRRPHDCGDRVERLGGLLRGSWDAEMIDELTPGPGEEVVDKTRNSAFLGTCSLDKILKERGVNHLVLTGVGTDVCVESTARDAYQMDYRVTTVSDATGTCTETDHLAALHALRIFGGTASTAEVIEALQELEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZR42</accession>
    <name>A0A0D1ZR42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235498.1">
        <property type="nucleotide sequence ID" value="XM_016379671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZR42"/>
    <dbReference type="STRING" id="91928.A0A0D1ZR42"/>
    <dbReference type="GeneID" id="27332410"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05327"/>
    <dbReference type="HOGENOM" id="CLU_294056_0_0_1"/>
    <dbReference type="OrthoDB" id="4120896at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115761" checksum="B7433A5DC39F0DB1" modified="2015-04-29" version="1">MAPQAYFDLEPDFENEIFQSKRFGKLRLVTGEVICVAMAARILFLLKNDHSSSCIPCHILTEFNVEIDIETIRAVVEKDFEVFAQDLSAGEYVVPTVPSIVGRGYHRGHILPAGIAYECINLREYGIRFVRRYAKIQWGLTIPDTVLDELIEQWETSLTIAGGEEPPNARPQHEGRRINRLALWPYPALERRHQLFEHPPPQYEPRPVYRNNSGQEVLLRHPREVPDNHPLGSQALTVPAYTAGEAPPTYSDIQLPLPASSHEEPHLLNPQAESTHQSLPSNRSLETGLAKARHSLEAEFVTYSKSDIVNYLFSNMPATHLDSELGILTFQQVSRAFRRFLTLSMLARSRPLREIDLWPQECLGNPPVLSEQGHRMAKLVRDVITELKVSACASSRRILTGTPIIENREGLTVLLRHMQRGRGAQELGDFVSSRHLWRAVLEELHESDNLHVKMVMKRTLMNPQGVTLEGLLEEIKQARLNDKSFQVTLQSSIATPRLLVMVAGADASPALSIGELEGDTHSEVVGRRLNSYVNLLLGAKIVLQATVGAMTDDMFIAARCQLERLISGGATAVGIDEESFQQLQEALERVHALRDAKEASRINPEYWAAVMTNSCLALFGRFSSSRAWIMMPTSDEPPRQLAFVYIPKPLFPYTIQASTNHRSTIRDAQRLALRWMHTFESDLEETISHFHGSYDVFLVQWEFFQGNSDPNPYAVSEFEELDKGYRHALGKLHDVICRIETASLIANAESKASFITELNTHQKLRYAFEERLATCWRLSFTKLADLDRAEAAFHKYCTELVRVAHWYLRGKQTPIDPANHKALAAEVDQMLTTLEAAQVYSECDAAEAQASGGMGQSDSVASSSDAESSPDSSISLANSQAVSPADGDEKMVPQVSGAATQQDEEVLIHGRAVFATESTADEEEPVLRQREVCPSNPNSGSGQDPLSGIIAVRLQQENLRPWQTTKMPWIGLERDNVRWVLPNFCLDREAAHDDYHACSKLKVVTENRDYRFPEGKENIPTRPGDVVPVDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTJ4</accession>
    <name>A0A0D1ZTJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236313.1">
        <property type="nucleotide sequence ID" value="XM_016380486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZTJ4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZTJ4"/>
    <dbReference type="GeneID" id="27333231"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06148"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="285" mass="31087" checksum="6B21276C9FCB3B03" modified="2015-04-29" version="1">MAVHKDKRRSVLVTGCSSGIGKALVDELRIQGLRVFAGSRSVDSLSGVVGVEPLELDPASPESIAKARDEVSRRTGGKLDILINNAGQWLESPAIETDLKAIKAMFDVNLFGVMEMNRQFSPLLIAAKGVIVNHGSMVRAMPHPMTAAYNASKAALSQYSNTLRLELEPLDVRVVELVTGRVSSSLISIPTLPESSIYKPLEPALVKRAREAETVQAPAVFAKRVVKSLLVANPAREIYKGTMASISWFLESYGPKWIYDPIMRTMTGLKQHRGELAKRASHIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZVN1</accession>
    <name>A0A0D1ZVN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03967</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236993.1">
        <property type="nucleotide sequence ID" value="XM_016378316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZVN1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZVN1"/>
    <dbReference type="GeneID" id="27331050"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03967"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="32667" checksum="FC68B0780ADEDD1F" modified="2015-04-29" version="1">MATSAMGKRLAGKTILITGASSGIGRSTAFEFARTSPEDLKLILTARRIDQLKTIAAEIEKEVGRGVKVLPVQLDVSKGSEVASFVDMLPAEFRQIDILVNNAGLVKGIARAPEIAEDDMNIMFATNVTGLINMTQAVLSIMLARGESGAGDIINIGSIAGREPYVGGSIYCATKAAIRTFTESLRKELIATRIRVIEVDPGQVETEFSVVRFYGDKSKADAVYAGCEPLTPDDIAEVVVFTAGRRENVVIADTLIFPNHQKEAHLTQTRTGFSNDHASQVIDERGLDGMKEMLKVESHRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWH9</accession>
    <name>A0A0D1ZWH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Post-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237228.1">
        <property type="nucleotide sequence ID" value="XM_016378551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWH9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZWH9"/>
    <dbReference type="GeneID" id="27331286"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04203"/>
    <dbReference type="HOGENOM" id="CLU_073382_3_0_1"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Post-SET" evidence="3">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="181" mass="20128" checksum="89285BCC0ABD594F" modified="2015-04-29" version="1">MKDTTSTLSSVMRVNQREGFHTSYSSSLVSLGPGALFARTTCPPMTLTSKARWSSVQVSENQHIELNTDLVFINHSCEPSLEFHVLSDASDQPVLELRVATRVDENGHPRGLSVGDELTFFYPSTEWEMQQTFKCLCGTKSCHGEIRGAKYMTPEQLRGYFINAHIEDLRSVPASDGKKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZX02</accession>
    <name>A0A0D1ZX02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetolactate synthase, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_04418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237443.1">
        <property type="nucleotide sequence ID" value="XM_016378766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZX02"/>
    <dbReference type="STRING" id="91928.A0A0D1ZX02"/>
    <dbReference type="GeneID" id="27331501"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04418"/>
    <dbReference type="HOGENOM" id="CLU_055003_0_0_1"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="94"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="352" mass="38670" checksum="74AB0F88EAC33410" modified="2015-04-29" version="1">MAGTRNLLSFAGRNALRKYRAQNGPSFLDSLAPASTRSKSTNSTSALAYKALHRRSPLPLPVTDTSPQYGAAAAVSSILYETPVASQAPPKKHILNCLVQNEPGVLSRVSGILAARGFNIDSLVVCNTEVEDLSRMTIVLQGQDGVVEQARRQLEDLVPVWAVLDYTSAALVQRELLLAKVSILGPEVYEELMEHHREMTTQEYDEPNEESHDTHEENAERRLQELEGNKQDEASLVQRAKEMLGQGASYHPNRLAASQALRHKHEHLEAITHLTHQFGGKVLDISTNNCVVEVSAKPSRIDSFMKLIAPFGILESTRTGLMALPRSPLYGPNEDLQREADEVVDASTLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZY55</accession>
    <name>A0A0D1ZY55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sphingolipid long chain base-responsive protein PIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237778.1">
        <property type="nucleotide sequence ID" value="XM_016379101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZY55"/>
    <dbReference type="STRING" id="91928.A0A0D1ZY55"/>
    <dbReference type="GeneID" id="27331839"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04756"/>
    <dbReference type="HOGENOM" id="CLU_046464_0_2_1"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39598" checksum="E0AAAC790FE0D112" modified="2015-04-29" version="1">MHRTYSMRQSRAPTASQIENPPPPPSSTKSGRLFGKSNFGHAFRKGTAGAFGPDLAKKLSQLVKMEKNVMRSMELVGRERMEVAQQLSLWGEGCDEDVSDVTDKLGVLIYEIGELEDQFVDRYDQYRVTIKSIRNIEASVQPSRDRKQKITDQIAQLKYKEPNSPRIVVLEQELVRAEAESLVAEAQLSNITREKLKAAFTYQFDAIREHCEKVAIIAGYGKHLLELVDDTPVTPGETRQAYDGYEASKAIIQDCEDALTNWVTSRAQVKPKLSTRTRSLSQRRKNSAKREGGVDLASQDQPMKDDRDSWVPAGQHGEYEQEEEDEEEEEEGEDEHHAGTNGEFPKSREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZG3</accession>
    <name>A0A0D1ZZG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238298.1">
        <property type="nucleotide sequence ID" value="XM_016376728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZG3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZG3"/>
    <dbReference type="GeneID" id="27329452"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02369"/>
    <dbReference type="HOGENOM" id="CLU_015910_1_0_1"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="671"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="706" mass="79948" checksum="15AF19261B5E3D96" modified="2015-04-29" version="1">MNGHSTKRDIKNHLLFEIATEVANRVGGIYSVLKSKAPVTTAEYGDKYTLIGPWNKNSAAVEVEALEPPAGPLRETIASMQERGIELLYGRWLIEGAPRVLLINTGTGYRWLDEWKGDLWSIAGIPSPAGDNETNEAIVFGYLVAWFLGEFISRERDRAVIAHFHEWLAGVALPLTKKRQMDLTTIFTTHATLLGRYLCAGSVDFYNNLQWFDVDAEAGKRGIYHRYCIERGAAHSADVFTTVSHITAFESEHLLKRKPDGVLPNGLNVKKFSAVHEFQNLHSIQKEKIHEFVRGHFYGHLDFDLENTLYFFTAGRYEYRNKGVDMFIESLARLNHRLKVTGSKLTVVAFLIMPAQTTSLSVDSLKGQAVTKALSDTVSNIERGIGRRLFERSVHWKEGDPMPDDKELITPADRVMLRRRLFAMKRHHLPAIVTHNMVNDSEDPVLNQLRRVQLFNSPSDRVKVVFHPEFLNSSNPVLSLDYDDFVRGTHLGVFASYYEPWGYTPAECTVMGVPSITTNLSGFGCYMEELIENSADYGIYIVDRRLKGVDDSVNQLTDYMFEFANKSRRQRINQRNRTERLSDLLDWKRMGMEYVKARQLALRRAYPASFEDADEFDDIIGGTEQKISRPLSVPGSPRDRSGMMTPGDFASLQEGKEGLSTEDYIAWRLPEEEEPDDYPFPLTLKTRKAPGELDSPAPLVGGMNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3C6</accession>
    <name>A0A0D2A3C6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239613.1">
        <property type="nucleotide sequence ID" value="XM_016378043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3C6"/>
    <dbReference type="GeneID" id="27330775"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03692"/>
    <dbReference type="HOGENOM" id="CLU_035756_0_0_1"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF7">
        <property type="entry name" value="PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0268928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="6">
        <location>
            <begin position="137"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="6">
        <location>
            <begin position="207"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="416" mass="47583" checksum="44E04B04CC50134F" modified="2015-04-29" version="1">MGFLGLGEPSIGTLIIFLGAWINRDFTTPVDQYAHEAQPDIERSDSPVTKVEPVAWNYQDRWRQREISIFGFRKTVNTPNTAVFQNRLASRLLLRFPFLIEIVYWALIYSIYQMGRGMLAERLRQSTVDVACHHALQVIRLEQRLHIFWEPAIQRFFLQYPGAMYWINRIYSYVHLPATITFLVGLYWFAITRNRTLARWRQPVSGPYLYESKRRSLAICNLLAFCVFSTWPCMPPRLLGDSKTPGHVEQARSFGFVDTVHGRDGAVSVFNTRRFTNQLAAMPSLHFGYSLLVGLSIMQLPIAHPGRCYRVSIPVPWSSKFGFDAFTATIRIPSLAKLMCQVLGFSYPALILTVIVATANHFIMDAIVGGTICLVAYRYNEAMLNFLPLEDCLLWCLRVHKPVQAPVCLPKGPDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3J0</accession>
    <name>A0A0D2A3J0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_00024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239668.1">
        <property type="nucleotide sequence ID" value="XM_016374392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3J0"/>
    <dbReference type="STRING" id="91928.A0A0D2A3J0"/>
    <dbReference type="GeneID" id="27327107"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00024"/>
    <dbReference type="HOGENOM" id="CLU_039478_1_1_1"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002248450" evidence="5">
        <location>
            <begin position="24"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW19452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="392" mass="42789" checksum="915C0BF8603E749A" modified="2015-04-29" version="1">MAPSKLVWAVSLLATTQVSQVWGKINVGPNFKYPIEDLDYDLPFSNIVTFAHLPWERCFNLKHDSAFDIAVVGFPFDTTVSVKPGARYGPRGIRSGSTKEKPGRTYNVNYNLDWHQNWARIIDCGDVPVTPYDNAHAYKQMEQGYRMLLHKPVTLTSSSPPSLDKVTHPRLISMGGDHSIMLPILRSLKSVYGPISVIHFDSHLDSLNPTKGYSGVVSEQSQFTHGTFFWHAAQEGCIANSSVHGGLRTKLFSPADYANDAEVGFSLIHARDIDDIGIQGIIEKIRAAVGESMAYISVDIDVLDPSAAPATGAPEAGGWTTREFKRILEGIKDLNLVGADVVEVAPDYDTNAEITSIAAADIMIDIISAMVEKGPLGSEKFDLKGNGGKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4V4</accession>
    <name>A0A0D2A4V4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240073.1">
        <property type="nucleotide sequence ID" value="XM_016374797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4V4"/>
    <dbReference type="STRING" id="91928.A0A0D2A4V4"/>
    <dbReference type="GeneID" id="27327515"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00432"/>
    <dbReference type="HOGENOM" id="CLU_013148_3_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049174">
        <property type="entry name" value="Beta-AFase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049049">
        <property type="entry name" value="Beta-AFase-like_GH127_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465:SF2">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20737">
        <property type="entry name" value="Glyco_hydro127C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="1">
        <location>
            <begin position="20"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="2">
        <location>
            <begin position="459"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 C-terminal" evidence="3">
        <location>
            <begin position="587"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="717" mass="80207" checksum="2B51EC76DBAE3E10" modified="2015-04-29" version="1">MSYPQESFIQTSLLPGSLLARRREVVSSNTLLYQLEVLKKTGRYDAFKLKWHPSYSDPPETWPIPNHLFWDSDIGKWIEGACYFLHKQPDTKIHSAINDLVKMIRSAQQPDGYINIHYTVVEPGKRFTNLRDFHELYNAGHLIEAALAHNDLYKNGDLLEPLIKYVDLLCRTFGPGKDQIHGYPGHPEIELALLRLYQRTKDPKHLDLARYFITERGNPAGVDGRHYYVVEAEKRGDPAHARMVYWGGNDDALWYYQAHKPIVEQETIEGHSVRAMYLLTAASDLVGMSTTHPVAGASEQQHDDNTRPLQDAIYRLWDNMVERKMYVTGGIGAIKRWEGFGLEYFLPQSTDEGGCYAETCAAIGVMMLAERILQYDLDRRFGDVMELCLYNAMLTSMSHDGTKFTYVNQLASSDADASKREEWFTCACCPPNVLRLFGQIGGYVYSDKRRTTEKDDATQVNVHLYVPSRHEVEVGGQGQGQKVVLTQTSNWPWDGRVEFEVQGTTSDTVAGTARVSIALRIPAWAKSWKITPSTPTAAAAAATTTGGGHADADADAGTTLQKGYLILSAHWVSQHPKFTLDIDISPRLVSPHPYTNQDTVAVARGPVVYVVEDVDNAWVTDHFKGVQLDPECSIRERTVTDGTTGDTFVALTVPDGGASILPSAGIHASPGVETGKLREVERSAEAVIDELHFVPYYFRANRGGRGQARVGLRRWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5W1</accession>
    <name>A0A0D2A5W1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_00742</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240383.1">
        <property type="nucleotide sequence ID" value="XM_016375107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5W1"/>
    <dbReference type="STRING" id="91928.A0A0D2A5W1"/>
    <dbReference type="GeneID" id="27327825"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00742"/>
    <dbReference type="HOGENOM" id="CLU_025505_0_0_1"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000243">
        <property type="entry name" value="Probable transcription factor steA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000390">
        <property type="entry name" value="Transcription factor stea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="552"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="597"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="662"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW20167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="688" mass="76406" checksum="E15A056A3D6809EC" modified="2015-04-29" version="1">MAQPQKPETFMLSNEAQQSLPQDAQVALQQVDNLKYFLISAPVDWSPDSLIRRFLLPTGEYVSCVLWNNLFHISGTDIVRCLSFRFQAFGRPVKNPKKFEEGIFSDLRNLKSGTDASLEEPKSPFLDFLYKNNCIRTQKKQKVFYWYSVPHDRLFLDALERDLKREKMGQEATTKAVAEPALSFEFDSSQSLFEQLTKAQQANSSSFATANANVNYSQSTSPVLRATDSMPPPQMMPTQIPRSQEQPPAMYTSMAMQTPITTTAMSREQDFSAIAYDRNGLPFDRSHMRHASMPAYMEYSPAPSFVSSHFEDYSTRGLSYEPITPPQHAVPVGAEPAYIANEDTGLYSAIPEMQPMPAYNPMASLPPSTLAGPTYAAAPRPFPPANVYSVIEGSPTYKARRRRSSIPSSIMNAVAANAVAQVTHGMKAHVPQRPSDLRRSMSSSVLPIAEGDESGDHSPSGLSHNYAASFAHKVDHLNDYSRHTTPLASLEEDPVQSMGMVTGPEGMPGLIGDDMHPASMHASPAVRLERPGPVRRARSATMMELGVPYKSHSCPIPSCGRLFKRLEHLKRHVRTHTQERPYVCPYCNKAFSRSDNLAQHRRTHESQHDGQPAPTTSEEELENEENDFGSMDELSSPDEVTRPTSVSGMMAMSMPPPSTLVMQSMSQSMSQPMMAPSQLVQPSMLQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A649</accession>
    <name>A0A0D2A649_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240483.1">
        <property type="nucleotide sequence ID" value="XM_016375207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A649"/>
    <dbReference type="STRING" id="91928.A0A0D2A649"/>
    <dbReference type="GeneID" id="27327925"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00842"/>
    <dbReference type="HOGENOM" id="CLU_021934_0_0_1"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="368" mass="40295" checksum="8CA4EB54BF088171" modified="2015-04-29" version="1">MAAASPLPPHLRSDREVHVVISILSGQRKAQEYYDDTLKPFLDGHQIRYSTHTTKSSKTITELTTSLFLPNAVKGVKQTIILLSGDGGVVDVVNTLTSTLNRSSDDIRMPSVFMKPAVVLIPTGTANALAWSSKVAGDPLDAMLTGTPRPLPTFQARLSPGARLVVDEGQGRELLAASDDAETVTYGAVVFSWGLHASLVGLSDTTEYRKHGLQRFRMAAEQLLKDDHKYRGKVKWRKAGGEWTDVRGLEHSYVLASLVSNLEETFRISPATKPVDGTLHLVHIGSEPASEIMRILGLAYQAGQHVTDPKVSYEDIEGLRIEFYEDDEQWRLVCVDGKIIAPAKDGWVEVTKIPGSGVDGRRVVELVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8I0</accession>
    <name>A0A0D2A8I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-coumarate-CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241283.1">
        <property type="nucleotide sequence ID" value="XM_016376007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8I0"/>
    <dbReference type="STRING" id="91928.A0A0D2A8I0"/>
    <dbReference type="GeneID" id="27328729"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01646"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF194">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="454"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="61751" checksum="D75E969C1CA382D5" modified="2015-04-29" version="1">MPYSSPYPPLDIPKQNILSYLFPPHKPLSTKPLWIDSRDPTISLSQAQMLLWIRRFAVGLDKLGVKEQQAVMVLTPNTLYVPAIYLASAGSKRYFTGANPIYTVSEVAHQMKAIEAAVVLIHPSLLETGVAAASQANIPKDRLFIFSETESSPQHGVQDWRSMLASEAEAESWQWDALEGEASVKTIAAINFSSGTTGLPKGVCITHHNLISNAAQCIFTRFEGTPYSADNPGPERWLAFLPLYHAYSQLWTINIACRLQVPVYVMGKFVFEDFLACIQRYKITTLQLVPPVLVMLSKRPETSKYDISSLRNIMCGAAPLKAELQNELTRRFGVVIVQGWGMTETTCAGIMMPGMTQDSTGSIGHLLPNTEAKLADDDGNEVVKEGEPGELWLRGPQMLLGYWRNEQATKESKTEDGWFKTGDVAVCREGGKWWIVDRKKELIKVNGLQVAPAELEAVLLEHPDIADAAAVGITVHDEELPRAYVVLQERAKGKVTEDDIKKFVANKVAKHKRLEGGVKFIDEVPKLASGKIVRKLMKEWAKRDAKEVEGQVKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A9W5</accession>
    <name>A0A0D2A9W5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutaminase</fullName>
            <ecNumber evidence="3">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02107</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241743.1">
        <property type="nucleotide sequence ID" value="XM_016376467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A9W5"/>
    <dbReference type="STRING" id="91928.A0A0D2A9W5"/>
    <dbReference type="GeneID" id="27329190"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02107"/>
    <dbReference type="HOGENOM" id="CLU_027932_0_0_1"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.710.10:FF:000005">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544:SF29">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="465" mass="49965" checksum="591A9F08D94478A0" modified="2015-04-29" version="1">MKSPIPDYLNASLEKVRPIEDGKPAQYIKTLANADTSKLAVALVMVDGNVYSAGDDQVEFSIQSISKAFVYAIAIEDAGLERVLEKIGVEPSGDAFNKLSLHKGNNRPMNPMINAGAIAAHSLVVHPDATAEERTDRILKTLSRLAGRQLHVDEEVYEAELEDADRNMGIGYMLKAAGIISCKPAEVVKGYIRQCSINVNVRDLAMMAATLCNAGVNPVTGEKIMPADSVRQVLSVMTTCGMYDAAGQWVSRVGIPAKSGVAGGVIGALPGQVGIAAFSPKLDDRGNSVRAVALFELLSRDMGFHMMDVSQIARASVSTSVAKIVAGKDDPHHPNCDRQVVIFALRGAVRFAGSERLTRAIVRELGEPNPKDPGSGQHRDACAIVISLRDAFSLNLVARRVIHESIKRLLAENKTVVVLDPNGVLQMDLDSLPTHQQPRIVESEQQAREYIGGAGCSAVLQSDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATD5</accession>
    <name>A0A0D2ATD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230184.1">
        <property type="nucleotide sequence ID" value="XM_016386052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATD5"/>
    <dbReference type="STRING" id="91928.A0A0D2ATD5"/>
    <dbReference type="GeneID" id="27338827"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11744"/>
    <dbReference type="HOGENOM" id="CLU_015286_0_0_1"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="78755" checksum="E72DF87F53F4E1D4" modified="2015-04-29" version="1">MAFQNFYFTFIHTTNVGRFVYWARNHPSTQTFWSMQSVPLMRATCRLGRPLLWRRIARPSRKNLRSTCVPTGLRTLVTESGDSANASFVGTVPETLQTASQNTPASRSSLQKNAILTSRRLPVSCPGCGALTQDVEPREAGYYSRSRKAVRTYLRESERRGQSKDGEKGAEADATDDESGEDVNQGHADETREIQHPLLPPMCDRCHTLIHESRGQPIAHPSIENIADSIAESPFSKNHVYHVMDVADFPMSCVPSIYKQLSLAKPRSQNRRSQHSFSSKPSLSFIITRSDLLGPSKEMVDRLMPKFIAILRTALSRTGQNLRLGNVHLVSAKRGWWTKDIKESIWQRGGGNWLVGKFNVGKSNLFEVLFPKGSSGHDSVHDELRRRREAKADDFLSVDGLLPPPQPEVPFPAMPVVSSLPGTTASPIRLPFGDNKGELIDLPGLERSGLDKYVKDEDKLDLVMTHRPTVTQHNIKPGQSLLLGGGLVRITPLLDENDPSTIMMAYAFVPLKSHVTATEKALSTQQQERESGIESILAEDAGPHMASAGRFELKTNVTKSRAGAVIRAGVDPAKLPFQVYATDILVEGVGWVELVCQVRKKPRAPPPTGLPDETTGEAMNERDVPTSDDLSIGSTGFVPFSASISKGGASDRPGYPRVEIFTPEGRFIGQRECLDVWQMWNTGKPRKDTRAARPRKPMSGAKKRAKTARRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AU36</accession>
    <name>A0A0D2AU36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein S35, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230474.1">
        <property type="nucleotide sequence ID" value="XM_016385530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AU36"/>
    <dbReference type="STRING" id="91928.A0A0D2AU36"/>
    <dbReference type="GeneID" id="27338303"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11220"/>
    <dbReference type="HOGENOM" id="CLU_049223_1_0_1"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44642" checksum="ADE3CE93F5121695" modified="2015-04-29" version="1">MPPRIPPSTASIALPTPSVHTHCKSCFNRAFSSTPTSQTRLRAEMFAWLQGPGAVFKRPLPGSTNYLSAYDRRGNLLRQRDQRSGDSSEDSSENATPSESEEDLRPFPRNLHFISQSILSEEVQHEIWHRVQVLQKSVRQVSVEMGIDMRRVAAVVRLIEVEKKMQAEGQELAIPYAKAIHSMVPVNRLNQTTRRPMEQHESINDLEQHPLTYPQLFHPTSESRAFNRTDAGRVFSGAPRLPDDQDAGQGGTPAREPWEDTKPEYVGKAGHSHPILKPADARIPHPQMIADELDKQNPRLANDRQRRRHLSAQRLEEDARKRKEAKELKARLEEENRTRVDTGRWQFIFTNVAATREGTKLDGRGTKSPGFRYGVPSQERKKGQVKIPTKVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUU1</accession>
    <name>A0A0D2AUU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230704.1">
        <property type="nucleotide sequence ID" value="XM_016385760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUU1"/>
    <dbReference type="STRING" id="91928.A0A0D2AUU1"/>
    <dbReference type="GeneID" id="27338535"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11452"/>
    <dbReference type="HOGENOM" id="CLU_103010_1_0_1"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="232" mass="24569" checksum="B0D994C52E6D91A7" modified="2015-04-29" version="1">MAANPVVLILGSGPRVGAAVAAKFFSSGYKVAVASRGGTGTKNSDGYLSLKADFANPASIPALFDAVKAEFQAAPTVVVYNAAALTPPPVQDNIFSIPVETVTKDLNINTVSPWVAAQQAVSAWATLPKGTKKTFIYTGNGLNTTVIPVPLMVDLGVGKSASAYWLGTADALYSSQGIRFFYTDERFEDGKVKGQELDGPAHADFYAQLASHPDNVPWLTTFVKDKGYVQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVH5</accession>
    <name>A0A0D2AVH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sof1-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_11404</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230656.1">
        <property type="nucleotide sequence ID" value="XM_016385712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVH5"/>
    <dbReference type="STRING" id="91928.A0A0D2AVH5"/>
    <dbReference type="GeneID" id="27338487"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11404"/>
    <dbReference type="HOGENOM" id="CLU_033999_0_0_1"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000657">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000743">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="9">
        <location>
            <begin position="353"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="395"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW10440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="443" mass="50012" checksum="9A081570B2BD80F1" modified="2015-04-29" version="1">MKIKSLTRAPPPPGDGAVRQSRNLDPSHHPFERAREYTRALNAVKMERMFAAPFIGQLGVGHVDGVYSMAKDPGSLERFASGSGDGVVKVWDLPSREEVWQARAHENVVRGMCWTPDRKLLSCATDKTVKVWDPYNGEKNGVPLTTYLGQGAFTDISHHRDHSSFAASSSAISIYDLSRPASGPSQVLRWPTSTDTITAVSFNQTETSILASAALDRALVLYDLRTSSSISKVVLRLASNAISWNPMEAFNFAAANEDHNIYIFDMRKMDRALNVLKDHVAAVMDVEFSPTGEELVSASYDRTIRLWNRDRGHSRDVYHTKRMQRVFSARFTADNNYVLSGSDDGNVRLWRTNASSRGGIKSARQRQKLEYDQALIKRYSHMPEIRRIKRHRHLPKTVKKASEIKGEELKSIKRKEENVRKHSKKGSMPRQSEREKMVLGTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXH6</accession>
    <name>A0A0D2AXH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231361.1">
        <property type="nucleotide sequence ID" value="XM_016384759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXH6"/>
    <dbReference type="GeneID" id="27337528"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10445"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="24"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="360" mass="38493" checksum="D38A70A9AE8E1BA0" modified="2015-04-29" version="1">MPDESGQLSEPDDNATPPPDGGYGWVCLACCFVINCFTWGVVASYGVYLSYYLTINAFPEARPLEYAFIGGLNFGIAMLSAPLITHLARSYGIRLPMLAGAALFGGGFIAASYASRIWHLYLSQGALVGLGVGFVYVPSIAVLSQWFAKRRSLANGISAAGSGIGGLIFSFAGGALIEHLGIGWALRITGATALLANLLAAILIRDRNGIIRPKQHPFDSRLASRTDVLLLLSWAFFSMIGYIPLLYSLSDFSISIGLSRTQATQVTAFLNMGTAIGRPFIGVASDRFGRFGVATSLTFLCGLSCLVIWVPATTFGLTTFFGVLSGAILGVFWMVRIIPGTQNSTFRCSADLLDYRATLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXL8</accession>
    <name>A0A0D2AXL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231421.1">
        <property type="nucleotide sequence ID" value="XM_016384819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXL8"/>
    <dbReference type="STRING" id="91928.A0A0D2AXL8"/>
    <dbReference type="GeneID" id="27337588"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10505"/>
    <dbReference type="HOGENOM" id="CLU_012966_2_1_1"/>
    <dbReference type="OrthoDB" id="20772at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="551"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="806" mass="88965" checksum="47B24C63B56259A3" modified="2015-04-29" version="1">MSLYLSDDDLPDLAAIVAPRPLMATSTNASVRRSPRKKAGPAVCESRSPHKKDTTVKSLIQEPQIHLESHQTSGRSPAKRTKPPKAASIVDAIPNLPRNSSTTEMLLTSNNRRSAASPQSSLRLTHVASLRLPQKSVAMGEGEDQEEQTVSRLVLDTHRLQSNDAGSMSRMSRITEAARRSAPEKTRKQKAAGSLASRFVLKEARCNDDVESSMDEEDEDEDTDLSGFIVDDNADLSYYGTSASEADDDWVAPTQQPRRASPRKRLHRGRRSLQRREPEEGSYSEKENRINGGLADALRNMRLKEDTNEVKEKIVEVIDLTTSPLTSPKLISTTAQPINSPQFIDSKKPPTFTGTINVFDAPIKLAPPSEKPSLIDTPQLAGVSAMEKTEDQVPSEIPANNEVKTPPATPPKSPVKLKSPSKLLSPSKRQLIPRSPHRQSTDAFWDHNTVNEWIDEYSPKKAPATSPKKVGLARYQIWSDSEEDQDEDMTISDSFPSPCTSPRKAGGKGRSPTKSPEKEEKKRQAEEKRAAMSRKRNFDSSKVQLAIDLLRELDVGVADSQLGRLAASTGGVKIIWSKTLRSTAGRANWKRTVTKLSGSPIKGGEVSVPGVKVQHFASIELAEKIIDCEDRLVNTVAHEFCHLTNFMISNVRDQPHGASFKQWAAKVTCHLRKSQVEIWRQVEVTTKHSYVINHKYLWVCAGRERSAAMAFLNIEEDEGCGAEYGRHSKSIDPEKHRCGKCKGRLVQVRPKPRASPRKKLLDAPVKKGREGSTDSTTSSNSSSRMSAGSDSTGTVGRMIDYVELSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZ23</accession>
    <name>A0A0D2AZ23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232159.1">
        <property type="nucleotide sequence ID" value="XM_016383536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZ23"/>
    <dbReference type="STRING" id="91928.A0A0D2AZ23"/>
    <dbReference type="GeneID" id="27336299"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09216"/>
    <dbReference type="HOGENOM" id="CLU_077732_0_0_1"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25199" checksum="8094013A6BC62473" modified="2015-04-29" version="1">MPPRGRRSAKGSTSAHAQSRLSFNNSARVTKPGARQDDSAKKAASKLSEVTPAPVEHEIETPEPDADDESQLTEVQATPEEPELKEVDVAIRESPLKPRTTNPKAKKKSSVQDKDERELSAEKITDAQIRKYWKAEEDGRLAPRVHQENLSLHEKILRHFDLSSQFGPCIGIQRLQRWRRANMLGLEPPVEVLAVLLREENKKTSQGCGKLAYIDELAGGKVVLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZY8</accession>
    <name>A0A0D2AZY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_09570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232509.1">
        <property type="nucleotide sequence ID" value="XM_016383886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZY8"/>
    <dbReference type="STRING" id="91928.A0A0D2AZY8"/>
    <dbReference type="GeneID" id="27336653"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09570"/>
    <dbReference type="HOGENOM" id="CLU_017779_3_1_1"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF116">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="142"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW12293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="571" mass="62344" checksum="6CC6F65441D1B651" modified="2015-04-29" version="1">MTRLRLFRLLARPQLKRVSHLQTLPHYHFRRLISQDSELSRPNKKTSDGSEHFFGGVFIGAGAVLTVLFYSDGLSLLGNAPEATNSTTPLASLTAPSYNLSDKNIHDAKNEFIALLGKDGIDDDLGARISRSSTDWSPAPRGDLDRPCLIVYPTTTEDVSNIVKICHHRRIPVIGFGGGTSLESTLAAIHGEVCIDFRRMNKVIEVHDKDLDVIVQPGVGYVELNEMLGKVGLFFPPDPGPGAQIGGMISQGCSGTSAYRYGTVKDWVIGLTVVLADGTVIKTRRRPKKSSAGYDLTRLFVGSEGTLGLVTEATLKLTNKPENVRVAVAAFPSNHDAVNAAVKIVQKGVPVGALELLDGISMKAINNSGYCVKDFKEAPSLFLKFSGSENVVQEQIQQVRALSKESNCLSFQFGKDEAESDAFWHARKTMLWSLMTLKRNPGDKFIGTDNAVPISRLADIIDITNRKIQESGLVGACCGHVGDGNVHAAIFYDEVEKEKAEKIVLEVERLGIEMDGTITGEHGIGLEKRDRLVDELGKDSVDTMRRLKLALDPLCLLNPQKVVRLTTNTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B080</accession>
    <name>A0A0D2B080_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232316.1">
        <property type="nucleotide sequence ID" value="XM_016383693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B080"/>
    <dbReference type="STRING" id="91928.A0A0D2B080"/>
    <dbReference type="GeneID" id="27336457"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09374"/>
    <dbReference type="HOGENOM" id="CLU_043296_0_0_1"/>
    <dbReference type="OrthoDB" id="427960at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="289" mass="31220" checksum="8734C12AD0434311" modified="2015-04-29" version="1">MAGLSTQGAQAQPKSMSSRLLNMKFMQRAAASTATSPAAATQSSSSPGVVHQPSKRRRIDYETSSPSSTPGTPQTPTTEPQISTFGQSRGGISTFDRGEGADTEWVLDLKMTFPNPSQTAHGSRKDGDRVNGTRFNQLSQITDGDSDSEEDDIWNNGPPGRQTYGSFKTKRGSRSQAARDVGNGADSPSDESDGEEGEEHDHSNHRTPTRNRKKAESKGDDSDEEMKQVRRAIEAKHRNMSGQGQVHRGSPGGGGWNSRSPVAGNPGQGPKRRREEGNYKAHKKARKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0G9</accession>
    <name>A0A0D2B0G9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232431.1">
        <property type="nucleotide sequence ID" value="XM_016383808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0G9"/>
    <dbReference type="GeneID" id="27336574"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09491"/>
    <dbReference type="HOGENOM" id="CLU_088979_1_0_1"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="241" mass="26378" checksum="31F0F5E5393FB272" modified="2015-04-29" version="1">MASPDHIQIGNLTGVFKVVSKVFDPFFPNMSPPPSTVNQEKHRESGPWLTIGLGIFVDEQNKDLSDDIAPLLELQNINWLIRKMMATGAPTLDIKEYVDSDGGGKAKLEITLSGPAGIKGLDHKVLDWEPVKKSNGPFGLVENRGRYYSGKVEPVSSPLADEVVEFLNAETLADGSPSAWAGTSADQHLHTAMISEGGGWISEQTWGFEIIDGQRYHTRRGIVSKQGGETRRGRLVYDYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0R9</accession>
    <name>A0A0D2B0R9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_09577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232516.1">
        <property type="nucleotide sequence ID" value="XM_016383893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0R9"/>
    <dbReference type="STRING" id="91928.A0A0D2B0R9"/>
    <dbReference type="GeneID" id="27336660"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09577"/>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="116"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="632" mass="67922" checksum="2D5D404CEA03996F" modified="2015-04-29" version="1">MTSPPNKASFTCLDEHVADNGVSHAASFASDTSASSVDVVGKPQYSDPSHNEAIKQTAKTYVRPSLAPRISTIARRHSFIDEEEDPVAATVAVNAASSTSTKVEAVTWSSLPKKGQLAVLTIARLSEPLTERSLAAYMFYQLRSFDPSLPDSTITRQGGLLTASFAAAQFVTAVWWGRAADTPWIGRKRVLLVGLFGTCVSCIGVGFSKSFAQALFFRACAGCLNGNVGVMRTMISEIIKEKKYQSRAFLLLPMCFNIGVVIGPILGGFLADPIASFPNVFGPGSAIGGDSGVDWMTTFPYALPNVVSAFFILTSAICLFLGLDETHPALKNRPDYGRRLGKFLFRLLCRWRGKGVEEYEYTELSDHQIELQDAAAAADLEEEAHEPRTSDTESLRSNQQPHNPAKPLLRRIYSKNVILTLLSHHLLALHLSAFNALVFLFLPAPRSDNNEARLPFSFAGGLGLSSERVGLATAIIGVIGFPLQIALYPKLNSKLGTLPSYKLFLPFSIASYFLMPYLALLPDKAYLVWPALTVALALQVISRTFALPGQTILVNNCTPHPSVLGTIHGLAQSISSGARTVGPTLSGWLLGVGLGNNCVGAVWWGIAAVAALNWCLLWLIYEGDAGAAAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B303</accession>
    <name>A0A0D2B303_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233196.1">
        <property type="nucleotide sequence ID" value="XM_016382493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B303"/>
    <dbReference type="GeneID" id="27335250"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08167"/>
    <dbReference type="HOGENOM" id="CLU_043410_0_1_1"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36911" checksum="C304BDFCFA3A767A" modified="2015-04-29" version="1">MGSYTPNNDQEIHTVFIPEDVRRSGKATLDIIAEGVAFLHKDGIIVLENAIDTEHIDTLNAKLAPEALEIAADPDHHFNFGTQTRNMDQAPPPTRELMYKDIWCNPFAAAILSATLGPRPVIHYANGNTALKAAPDGRQPVHSDCEFAHPAYFPFAYVINISLVDVTAENGGTEVWVGSHHVSVQDAHVSGCDNEQMLSIRPELLEERRKHSPPFQASTKKGSLVIRDLRLWHAGMPNLTDEPRVMLAFVASPEWWQGKSKILLPKDVKEMVESWKDEFQYDAEYVEGEVEYKKLSSSNVDFGSKSKILERYESELKVWPNYVPRWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B375</accession>
    <name>A0A0D2B375_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ERCC1-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08227</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233256.1">
        <property type="nucleotide sequence ID" value="XM_016382553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B375"/>
    <dbReference type="STRING" id="91928.A0A0D2B375"/>
    <dbReference type="GeneID" id="27335310"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08227"/>
    <dbReference type="HOGENOM" id="CLU_041616_1_2_1"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="56"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="378" mass="41490" checksum="74D2F8F21BC08E4B" modified="2015-04-29" version="1">MAEEFDDAEFLAAEAGVQRSASAVPQRTASPAVTNVAKVVQPKPQAMPGRQGPSAILVSTRQKGNPILNHVKSLPWEYSDIPCDYVLGATTCALFLSLKYHRLHPEYIYSRIRQLGKLYNLRILLTMVDITNHEEALKELSKTSMINNLTLILCWSSQEAGRYLELFKSYEHASPASIRAHQAETYQESLTEFVTTPRTINKTDAASLISNFGSLRAAVNAQPEELALVPGWGEKKVKAWTTIVREPFRVKRAAKSSAALLRQESTMYSDGDSAPLTPDPVPTPIPISTVRSLSRQGTPMNTVAESSEGPRGLKRSRLEEIPMNEGIDADEAALLAMAEAESHLTDVEQPKVAQAITRKEPELSEGVMAALAKLRQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4Q6</accession>
    <name>A0A0D2B4Q6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_08876</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233901.1">
        <property type="nucleotide sequence ID" value="XM_016383198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4Q6"/>
    <dbReference type="STRING" id="91928.A0A0D2B4Q6"/>
    <dbReference type="GeneID" id="27335959"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08876"/>
    <dbReference type="HOGENOM" id="CLU_125186_1_1_1"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW13685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="93" mass="10514" checksum="248DBE7D813883E8" modified="2015-04-29" version="1">MTGRGGGGRKTLLAPIHFIFSLLQKRSTVSIWLYENLRTRIEGKIRGFDEFMNLVVDDAVEVQLATKDTPEKRRQLGQILLKGDNVSLIQSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5D8</accession>
    <name>A0A0D2B5D8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_06894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234329.1">
        <property type="nucleotide sequence ID" value="XM_016381227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5D8"/>
    <dbReference type="STRING" id="91928.A0A0D2B5D8"/>
    <dbReference type="GeneID" id="27333977"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06894"/>
    <dbReference type="HOGENOM" id="CLU_005482_2_1_1"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000006">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="10">
        <location>
            <begin position="362"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW14113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="724" mass="78964" checksum="737094CBFB91D45A" modified="2015-04-29" version="1">MGCYGQDLFEPIALGQPPTNIQQQGGHPVPRLGITNATGPIETNKFYENFVLGTQNFPAFLMPYTLAWSKGSGNAQSWGMAISHVEQSQKVFGPANTAIPNSPDSYYINPLGIQSLILSAAEFQSNTILTTDSLLAFSANVHLQPSTGSTSILTMPVVQGMVFITGQYINLQPNIQSSVFFRSVSAAGEPKPGVFKYRITLEDGKVWLLYALPSNGINPNFKLASSTLLQGPENWYGDVQVAKLPSDGLDFIYDDAAGTWPTAGQVGGHAQDAKAQYSLSWTKAGPFSENSTLVMFALPHHVQSFAATSPKTVTNLTLATTTVGNATAVIADYWVLEENELPTSLGFAPWRPADSSESTMNLSAAAVAAIQQVSVTEASQNMSAQTNLNSMYYSGKALSKFATLVYTMHDLADQADLAKTALLELESCFEVFSDNQQEYPLLYDTDWKGIVSSASYVTGDDGVDFGNSYYNDHHFHYGYFLHAAAVIGYLDPTWLIKNKDYVNALARDVSNPSSLDQYFPVFRSFDWYHGHSWAKGLFASGDGKDEESSSEDSMFAYGLKMWGKTIGDASMEARGNLMLSVLARSLQNYFLMTSDNVNQPAAFIGNKVTGILFENKADHTTYFGNDLSYIQGIHMIPVMPFSTLTRTQQFVAEEWTTYFADGAVRDATGISGGWKGIVYANFANINPSAAYSFFTQDNFDMSWIDGGASRTWYIALSAMLGGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5P7</accession>
    <name>A0A0D2B5P7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation initiation factor SUI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234206.1">
        <property type="nucleotide sequence ID" value="XM_016381104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5P7"/>
    <dbReference type="STRING" id="91928.A0A0D2B5P7"/>
    <dbReference type="GeneID" id="27333854"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06771"/>
    <dbReference type="HOGENOM" id="CLU_082805_3_2_1"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW13990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="114" mass="12909" checksum="15B70D507DC3E97B" modified="2015-04-29" version="1">MSTIQNLKTFDPFAEADDDTGEAKQSQNYIHIRIQQRNGRKTLTTVQGLPKKFDQKKILKVIKKKFACNGTIVTDSEMGEVIQLQGDQRKDVQEFLVAKDGLELDAKTIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5S6</accession>
    <name>A0A0D2B5S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234499.1">
        <property type="nucleotide sequence ID" value="XM_016381397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5S6"/>
    <dbReference type="STRING" id="91928.A0A0D2B5S6"/>
    <dbReference type="GeneID" id="27334148"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07065"/>
    <dbReference type="HOGENOM" id="CLU_014528_0_0_1"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.400.10:FF:000001">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF261">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="29"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="713" mass="79142" checksum="2A395FD56958FA6E" modified="2015-04-29" version="1">MVAFTIQTNGVTNGVTPNGNSTHSSHGLDVLIVGAGIAGLTAAIGLRKQGHHVQVFEQSRFATETGAAVHIAPNANGILKRLGLHAEDIEANKMERFTEYTSSGHELRSIDLVEPNKLWQHDWRLAHRIRLHEVLKKLATSKDEQGPPAVLHLNSGVAEVDPREASLILTNGDVVRGDVVLGADGVHSVCRRKVGGELVKPFSSGKSAFRFLINRRAALEDPITQGLFRSAGELVTWYGTDRRVVMYPTSNNSLLNFVCIHPEQESEAGEDWTNDSNKDALLRVFKDFDPKCLALLSKADPDSLKSWKLLDMPVLDTWVNDRLALLGDAAHPFLPHQGQGAGVAMEDAAALSVVLEKGLKPEEVPARLKLYETIRYERANRIQEYSRQVGKDIQKDSKINMIEYSNYNFGHDEFDNSTQRLREWKWAQTPQIYWRMPVAFGPMPGPRQSHAGVVRDAVESTFTTASIKFKTSRTVLQNLFPPGVNGYRFKSPGTVAYCSFSCTTLNKMQWLGGTGYNHIGLYIHGVEYVKPDGEVISGTYMPILFESLTDPIVSGREELGMPKLYSAIDIYRGAESYRIKTSWQGSLWGNFRLDGLQPDDDLAAATGKVSGEDDDGILVYRYMPKVGRDFKGQSEAEYPVFVPFAEERPQPVTRRVWKASAASINIDALDWDALPTLHHVISRLEEIPVYEIVQAKVVEGVGVPDVAVARRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6V1</accession>
    <name>A0A0D2B6V1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_07187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234621.1">
        <property type="nucleotide sequence ID" value="XM_016381519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6V1"/>
    <dbReference type="STRING" id="91928.A0A0D2B6V1"/>
    <dbReference type="GeneID" id="27334270"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07187"/>
    <dbReference type="HOGENOM" id="CLU_413868_0_0_1"/>
    <dbReference type="OrthoDB" id="4161342at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="604"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW14405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="764" mass="87510" checksum="76BB7A9945D8DA95" modified="2015-04-29" version="1">MRRPLTDAEVSLIIDHLNQKEEPSQVLVKNTNRPYCSQPLHIGEQVRLIEEPDAVPMAAEQFDLETQEAAFRLVKSDSRIERGIRHAQPWIRIDGITRSLYHYQLYVMYWLLREEHESARQGALVNDLMGLGKTTEALCGTVFFSLVAKNAEHIKNHPEDHLSQMDATDSSKYCNVRDDFPLECACHVRSPAYRWKPRMGASLVLTPAGLLGTWATEWTALGINTTIVGVKLYIHHADYPGRYVGEEYHRRLRLQPGPGKIMMAPAEPQAYRVIILTSVESYQSCVADFLNNKAGHLVKRGTPRPDGIAWARVWRDEAHLRVNWDTTLYGILGRLVDNGDWADPPAFYALTGTPILRNGLLDVLPLVRCINIASPRLKDDPRFVEYLDDNELVKKAKGLARATRRRGTDRRLADEEEHRFEEDTAFFARMLPLYAIRRRGSTMQNGKVLTFIPPLNSFDIACTLPCGEDFLLLRQVEALLRNKLNKAWDREITKWIDEGGVRDDFMPDEELLLDNVFLARLLATAPGLARLGLREHLTWTYIRDRDWHSYPKCSNIYRNLRQLESTSGKLQKLREFLSRLDQCVAFDGICESLVIISEFPFICHLVHCFCIWLDYKAEWMHADTKPEERRAMVKKFQHPHQEGPPEIQIIIGTAAIMGQGLTLHRAHRVLLMEPSRHFAVECQNADRVHRLGVKTDVCYFYRLVNTNSCTEAALVVSQAIQNQTQCLLESLPTLQEVTDESETTAQLLQELSAFVNRENGVRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B722</accession>
    <name>A0A0D2B722_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_07522</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234954.1">
        <property type="nucleotide sequence ID" value="XM_016381852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B722"/>
    <dbReference type="STRING" id="91928.A0A0D2B722"/>
    <dbReference type="GeneID" id="27334605"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07522"/>
    <dbReference type="HOGENOM" id="CLU_007948_1_0_1"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF8">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YRBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="11"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="285"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="433" mass="45740" checksum="A3B312B22F456726" modified="2015-04-29" version="1">MVNGEAIAYSVSSFVCALYVLEFGADKFIDHTAIVAERTGIPQGIIGLLTAGAEWEELAVVVLSIARQRSSLAVGNIVGSCISNILGAFSLGLIFRKDEAPIIFDRSSKVYALLLLLLAIPIAGLSKFGHRGMWTTAGGIAIGVFVVYIASIAWFITRGRMVAPELSDSDSDSESEVGNDEGSFDGPEENHSSTHYAYGSFQESASPTPATAPTNTKFTQRANAPDDAAPNNSLVPLLTPPAVDTEDQSDSAASLDLEEALGARAAATSYRAALDGTYKHSVAYHVVVLVLGFLAILLSSYVLSRAASNLVDEMGISDVLFGVVVLSVATTLPEKFVAVLSGYRGQPGILVANTVGSNIFLLSLCMGILWVSTGGSFDRGSVNAAELGVMLGSTAVLTFTVWCGARWSRWIGGCMVLAYVVFLVLEFTVIRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8C4</accession>
    <name>A0A0D2B8C4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_05218</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235389.1">
        <property type="nucleotide sequence ID" value="XM_016379562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8C4"/>
    <dbReference type="GeneID" id="27332301"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05218"/>
    <dbReference type="HOGENOM" id="CLU_146833_2_1_1"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW15173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="121" mass="13190" checksum="825DFB206CDF32D8" modified="2015-04-29" version="1">MPISKLEASNGTSTPMASHTEHAPTVLKASYQSPTGLADFHHVIAAPVSHALNSEAKTQYLGELRASSRKLQDEINKFLTEKMDEDKKGQNQESTSGASLQKTQEELEEENYGEEVAGDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8D1</accession>
    <name>A0A0D2B8D1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)H:quinone oxidoreductase, type IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235399.1">
        <property type="nucleotide sequence ID" value="XM_016379572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8D1"/>
    <dbReference type="STRING" id="91928.A0A0D2B8D1"/>
    <dbReference type="GeneID" id="27332311"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05228"/>
    <dbReference type="HOGENOM" id="CLU_051402_0_1_1"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="194" mass="20825" checksum="05DA11E908178E57" modified="2015-04-29" version="1">MYGHIAQLAQAEKKGIEAAGGSADLYQIEETLPAEVLTKMHAPAQDTSIPFITPDILKTYDAFLFGIPTRYGNYSAQWKTFIDKLGQLWFTGALHGKYFGLFVSTATPGGGQETTCINALSSWVHQGMIYVPLGYATAFPLLANLEEVRGGSPWGAGTFAAGDGSRQPTAKELELATAQGKGFWEHVSKVSFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B972</accession>
    <name>A0A0D2B972_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235426.1">
        <property type="nucleotide sequence ID" value="XM_016379599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B972"/>
    <dbReference type="GeneID" id="27332338"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05255"/>
    <dbReference type="HOGENOM" id="CLU_068979_8_0_1"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="28"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="237" mass="25408" checksum="88B27541271B0F14" modified="2015-04-29" version="1">MGEMRLSSVVEAEPYRWPHNLSLGPDNTALIVIDMQVDFCAPGGYLDAQGLSIESTRAIIPRIQELLDAFRKGGYQVYHTREGHRPDLSTLSSRELLRSRNNPSGKGIGDVGPLGRLLVRGERGHEIIPELAPLPSEPVIDKPGRSAFQHTDLKLLLDNRGIKNMVICGVTTDVCVTSTMRDGNDMGLDCLLVSDASAAGQQHLHEAAVASVCEEGGIFGAVATTQEVLAAVGRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9V3</accession>
    <name>A0A0D2B9V3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235994.1">
        <property type="nucleotide sequence ID" value="XM_016380167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9V3"/>
    <dbReference type="GeneID" id="27332911"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05828"/>
    <dbReference type="HOGENOM" id="CLU_096861_0_0_1"/>
    <dbReference type="OrthoDB" id="5387413at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="233" mass="27529" checksum="E233AF1B41B9FE5A" modified="2015-04-29" version="1">MAKGATSQRVVNFAKEINSSRPPRDDEYFVMYRFAKHASKCNFCADPYACYEQDLDLCDRGRSYARDVSSYLFSKGAKPFSKIDRSNGDSVQVEIPAECEVINRLIKAWDRGMTLSKAKKPIIVNPPTRNPERHEKVETPKAKEYFYDEPRRSRNYDVVEIIPNSSRRGRERVYRDDHGAEERYRYVHKERPVSYHGSKGSLYERDEEEKRRRQQYDQQPIVIIAEPSRRYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9V8</accession>
    <name>A0A0D2B9V8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05833</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235999.1">
        <property type="nucleotide sequence ID" value="XM_016380172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9V8"/>
    <dbReference type="STRING" id="91928.A0A0D2B9V8"/>
    <dbReference type="GeneID" id="27332916"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05833"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_3_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000009">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="251" mass="27924" checksum="558373E965E7582D" modified="2015-04-29" version="1">MARRYDSRTTIFSPEGRLYQVEYALEAISHAGTALGILAKDGIVLAAERKVTSKLLEQDTSAEKLYILNDNMICAVAGMTADANILINYARQAAQRYLLTYNEDIPCEQLVRRLCDLKQGYTQHGGLRPFGVSFIYAGWDPQRQFQLYQSNPSGNYGGWKATSVGANNASAQSLLKQDYKEECDLKEACGMAVKVLSKTMDSTKLSSEKIEFATVGKTADGKIYHHLWSSEEIMTLLKEHDLAKEEEAETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDU1</accession>
    <name>A0A0D2BDU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237334.1">
        <property type="nucleotide sequence ID" value="XM_016378657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDU1"/>
    <dbReference type="STRING" id="91928.A0A0D2BDU1"/>
    <dbReference type="GeneID" id="27331392"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04309"/>
    <dbReference type="HOGENOM" id="CLU_047036_5_0_1"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="141"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="299" mass="35159" checksum="F26C793C9F066BF6" modified="2015-04-29" version="1">MPSGFSYRVDLAVANNIRLQEFYYNVHLNVFEKAWAAWYAYMQNDVLATGIMSFAMHEIVYFGRCIPFMIMDKIPYFRRYKIQGQKMPTLSEQWKCAKLVLLSHFTVELPQIWLFHPMAQYFGLSTSVPFPHWTKMAWQIALFFVLEDAWHYWFHRLLHTPRLYKMIHKLHHQYSAPFGLAAEYASPIETMILAFGTVGIPIVFCAIFKDLHIMTMYLWIIGRLFQAIDAHSGYEFPWSLHHFLPFWAGADHHDVHHEKFLGNYASSFRWWDAMMDTEAGSASAPKTREKKAAVAKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE90</accession>
    <name>A0A0D2BE90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237126.1">
        <property type="nucleotide sequence ID" value="XM_016378449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE90"/>
    <dbReference type="STRING" id="91928.A0A0D2BE90"/>
    <dbReference type="GeneID" id="27331183"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04100"/>
    <dbReference type="HOGENOM" id="CLU_023261_0_0_1"/>
    <dbReference type="OrthoDB" id="5383818at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238964" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="52"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="281"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="427" mass="43556" checksum="29D9C27A0AFEF327" modified="2015-04-29" version="1">MVALLYAALLGSASLIAGLPVAEKRAVTVLDQAAFEEAQQRDDTATRAFSSVPIKTSAGQCLFVDELSGDFRANLTPIQVGKCDGSEGQLWDVITAGKHDDQPGTMLIVSTLTQACFNFDPRRAAGNQVILFSCGGRADGGGSVTDSQLFPFAGSAGPQSFSPVNAPGTCLTVSGAVLDQTACDASDANQSFTFGDTVSASTAVASASTTSATTTVEVASPTTTSGSEIATITLAPTSSPTAVAPATSASVISVSRAGIVLDPSAAAEANPRDDTATRAFSSVAIKSSDGRCLFVDPTAGDFRENLIPIVLQPCDESANQQWDVITAGKHNEQPNSALIVSSLTQGCLNFDPRRAAEDTVILFSCGGRADGEGSVTNSQLFTFTSGQASLALQPENGSGDVCLVPNASGRLDQAACSGSADQLFTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEU2</accession>
    <name>A0A0D2BEU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_04326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237351.1">
        <property type="nucleotide sequence ID" value="XM_016378674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEU2"/>
    <dbReference type="STRING" id="91928.A0A0D2BEU2"/>
    <dbReference type="GeneID" id="27331409"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04326"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF5">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="19"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="392" mass="41521" checksum="251E87FF391F3788" modified="2015-04-29" version="1">MEAPDIPTQHKALVYDNPGSISTKIQYVDTPRPGVGEVLVKLTHSGLCHSDMAIMTNRWTARIEPTPKGQIGGHEGVGEIVAFGPGAEDQISGLKLGSRVGIKWMAYACCNCIICLAGLDSYLSIHCSGAYVCWQGLREAEFRKVSSTDNVVDRYFYPGTFQQYAIAPAHYVTPIPDGVPSDMAAPLLCAGLTVYSALRKAGAEPGDPVLILGSGGGLGHLALQIGSNGMGYRMMGVDMGDKETISRECGAEDFFDLAKYGQGGEETLASDVKAATGGRGVAAVIVCTGHNAAYAQALSLVRIGGTVVCVGIPEGGEVAMPNATPSQFIYLNAKVVGSSVGNRLEAIQLMELAARGKVKTHFQTKKLEDAAEVFELMDKNHLRGRIVFDLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGX3</accession>
    <name>A0A0D2BGX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238086.1">
        <property type="nucleotide sequence ID" value="XM_016379409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGX3"/>
    <dbReference type="GeneID" id="27332148"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05065"/>
    <dbReference type="HOGENOM" id="CLU_042952_1_0_1"/>
    <dbReference type="OrthoDB" id="5327145at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="427" mass="46980" checksum="928B67FBDF38A0DC" modified="2015-04-29" version="1">MLAARDQENIVHARQTAAAGKPLNQNIRSLHPKTPGNLKTPFRVSKNDENAPFTFKGQRGLNKDGPSKSDKNSFVTPLAPRNRAPLGAKTTNAKAAAFKTPAAAPLTSKPGHGVPKPSTARRSGRSKIVVSRAEPAEADVLTAPHEEDDEPDYGYAPPPPVALPDPPLDFNSEEFPPPLTREELSREIAELYLNSPKDENGFSLRLKKEQEEWERFDEERIKHTLKVTDMPVESPDRQVDAMIAAGPKKQRPPLSRVDSMQAKSAAEALSEPQPRLPSAALRPTQASEQKRKGILPSTKPRHLSTSTVSGAGRTTHAAVSKNTIGFPKAKKPPSIIPKGAGTDRSGPISVKKPAKVDQSKIHPKDFRDLYGSPPIESDMWFRLKEYELLENDEDKDADLVDDLFEPDFFPFDNSKLDDEDFQLPMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHJ3</accession>
    <name>A0A0D2BHJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238286.1">
        <property type="nucleotide sequence ID" value="XM_016376716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHJ3"/>
    <dbReference type="STRING" id="91928.A0A0D2BHJ3"/>
    <dbReference type="GeneID" id="27329440"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02357"/>
    <dbReference type="HOGENOM" id="CLU_020880_2_0_1"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF43">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239115" description="3-phytase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="551" mass="61415" checksum="6D78307ABB7AAFB8" modified="2015-04-29" version="1">MRLSFALFAVLPALSRASPFARQRRQSSGSSSSEPLLDINVIQSYWGQITPYADNAENFFGVNATGLPDGCQVEQAHLLQRHGSRFPTSYFDDGINNEDFAAKVYNWTLENSTEEFTGPLGFLNSYEYQMGEGLLVGTGAVQLFQSGVTFWERYGRVLYNATVGQVAYNASFPNGTARPKPVLRTTSQSRIENTQINWALGFFGTSFTDTPNPTLANATSPFSLVVIPEGGTENNTLASYDSCFNDYNLPEGYIGDLDLMFEYLPIYLADATDRLSQYVPSGFNLTVNDTYAMQSICAYETNYLGRSDFCGLFTEDEWAGFESTLDQEYYYDYSYGNPTGRAQGIGYLQELLARLQHQYITVSNSSVNSSITNNSRDFPLDQKFYADFSHDDIIISVLTAASLDYLRDPPSLTDYPPDPQRHFILSHLTPFAARLVTEVVGCTSGNPSPQNTTRTQYYPGQYGYEPSDATYKFVRMRLNNGILPLSSIRGGYCGNRTDGLCPLEAFIQSQESSYELSNYQYACFGNYTIDWPNNGTDYDGTIFSGSASGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHL7</accession>
    <name>A0A0D2BHL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231080.1">
        <property type="nucleotide sequence ID" value="XM_016384478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHL7"/>
    <dbReference type="GeneID" id="27337246"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10163"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW10864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57966" checksum="77EFFE374479B761" modified="2015-04-29" version="1">MSDIEKTPAQVVEPPEAAEPGSSTRISKVMGYIKGTTTNDLNVLGRDMLRKALEYDEAQLERDAIKVRRKLDFIVLPMMMCTYMLSFLDKQTLNYSNAYGLQADTHMKGDDYSWVASALYFGWLLGAYPWNVILQRYPIGKLLGCMLFVWGSVCMLQAAVFNFGGFFAIRFFLGMLEACISPAFVILTSMLWTREEQALRTSFWLSTNGVSSILGALLAYGSGHADGLAVANWKLIYLIVGAITFAWGFVIIIYLPDGPHNAKMLNEYERTVAVWRVSKNQMGIKHQAFVPYHIKEALMDGKTYLLLLMGVCTGILNGGVANFISSLIKGFGFDALKTSLLQTPGGAFELIGCMFFGWVATKKNMLGVSVIISSLPGIAGLIGLLTISIKHRYALVAMCWLQNVLGAPIILGWTLPGVNTAGHTKRTTVIGLFFCFYCGGNIIGPHLFLPSEVPRYFTAIKALLGTYCALIFFQVIYTVWCWFDNRARDKKGLHAQREDELLEGFDDLTDKQNLHFRYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHU4</accession>
    <name>A0A0D2BHU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238709.1">
        <property type="nucleotide sequence ID" value="XM_016377139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHU4"/>
    <dbReference type="STRING" id="91928.A0A0D2BHU4"/>
    <dbReference type="GeneID" id="27329864"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02781"/>
    <dbReference type="HOGENOM" id="CLU_034130_1_0_1"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051673">
        <property type="entry name" value="SSDNA_exonuclease_RecJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255:SF2">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="2">
        <location>
            <begin position="101"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="481" mass="52610" checksum="24ACB5B8B2E7D3DA" modified="2015-04-29" version="1">MPSVLKVSRQAVLRPFRKCTRGIIYSFATAPFRPLVLPQQANGTRGMKRASTSKPRPKLPEYCEVDPRRDETGKPIWPAPAEAIERVRTLIRECAASGKRTLIVPDKDADGLSSGVTLYRTLTTLGLDKSLIDVHLVQKGSNIHLRSEREAMAAKDPAYVFVLDQGSVAGPPVVDSPTTKSIIIDHHLSDQFPEGAEVVSACHYPPVSTTSLLTYEICKTLSDGIESACAYLACIGTHGDLGNTLKWLPPFPDMKETFKIYTKKSINDAVSLVNAPRRTSKYDVITAWTALLESTSPKDLLSNGRLQSARAEINEEVELNTHTPPKFSSDGRIAVLRIHTPAQVHPVIATRWAGYLNSKALEIVVCANSGYLPGVVNFSCRIARSARSRDPPVNIIESLKAAADLSTDGLRDRLGESFARGHKEASGGVVPVAAFEELMQLLRIGEKPEKKDGGEDPKPKKLKTVEKSPQKNTLGNYFRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIM0</accession>
    <name>A0A0D2BIM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4387 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231430.1">
        <property type="nucleotide sequence ID" value="XM_016384828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIM0"/>
    <dbReference type="STRING" id="91928.A0A0D2BIM0"/>
    <dbReference type="GeneID" id="27337597"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10514"/>
    <dbReference type="HOGENOM" id="CLU_1731487_0_0_1"/>
    <dbReference type="OrthoDB" id="4161653at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025496">
        <property type="entry name" value="DUF4387"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14330">
        <property type="entry name" value="DUF4387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4387" evidence="1">
        <location>
            <begin position="48"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="151" mass="16529" checksum="F14E984A893A6EF5" modified="2015-04-29" version="1">MEADLVKEKVKPKSTALNRIALGEDAVAEDKAATSVLLREPPPGHAFLADLATYIRSKNAGPYELTFDVIFSDPTRMNMVKATGILNRSTVARLYGIYEEDVLASLWWDPALAFKATIKRSRVSGGFWERDAHGAQQAVPLMELAVPVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIP2</accession>
    <name>A0A0D2BIP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like protein arp6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231450.1">
        <property type="nucleotide sequence ID" value="XM_016384848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIP2"/>
    <dbReference type="STRING" id="91928.A0A0D2BIP2"/>
    <dbReference type="GeneID" id="27337617"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10534"/>
    <dbReference type="HOGENOM" id="CLU_027965_1_1_1"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="53894" checksum="EFCE1E73EA59CD25" modified="2015-04-29" version="1">MPRQSKASTRHVPGLPSTAFVLDNGGYTIKAGFAPTDAAAADDGAALARCHTIPNAIVRSRERKTYVGSESAQITQWSEALFRRPVENGQVVSWEAEKEIWDRSFFDEKTAGKDVLVKSPEDTTLIFTEPPNSMPALRKNADEIIMEEWGFGGYSRMIGPSLNAYNDLHPLFEDVPSASHDPSFAQLPMECLMVIDAGYSHTIITPLYKGRPLHRAVRRLDFGGKHLTNLLKEMISVRHFDLHQDTKIVNDIKEEVCYVSKSFREDLEKTWKGNKGRSKPASAKAVLRDAGGGVGSMELDERQDDEIRVDYVLPDGIHLLKGFSRPHDPTPAAKKRKQAALAGATSVDSEITMTLGNERFTVPEMLMSPSDIGSKQPGIPDIVMQSLSVLPPLVQATMLSNVLVVGGCAKIPGFVERIEAELRAQIKTDWEVRVRKMNDPVTSTWLGGARMASHFPSVVREYGITKEEYWEHGSAWATRRFAYGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIT5</accession>
    <name>A0A0D2BIT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231485.1">
        <property type="nucleotide sequence ID" value="XM_016384883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIT5"/>
    <dbReference type="STRING" id="91928.A0A0D2BIT5"/>
    <dbReference type="GeneID" id="27337652"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10569"/>
    <dbReference type="HOGENOM" id="CLU_137480_1_0_1"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF2">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="117" mass="12969" checksum="8D11CD87EE9E8263" modified="2015-04-29" version="1">MPRGNGPVTKVFFKGSTDDFIVFIESPEDLARWKQDKSIPLAEVVNSFKIMVTHKHGAQGQLDGASKASLENEFGTSNEDEVIKKILEQGQPQIVQNPERHGDRNETMGPRQGHPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJY4</accession>
    <name>A0A0D2BJY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SLT11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor slt11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_10880</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231795.1">
        <property type="nucleotide sequence ID" value="XM_016385193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJY4"/>
    <dbReference type="STRING" id="91928.A0A0D2BJY4"/>
    <dbReference type="GeneID" id="27337963"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10880"/>
    <dbReference type="HOGENOM" id="CLU_027112_1_0_1"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12265">
        <property type="entry name" value="RRM_SLT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000396">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor slt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034356">
        <property type="entry name" value="Slt11_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="226"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="159"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="315"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW11579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="373" mass="40829" checksum="4B6E5E0848A3E7DC" modified="2015-04-29" version="1">MASRQIKQDLNRSGWETTDFPSVCENCLPDNPYVQMIKEDHGAECKICTRPFTVFRWKADRTARTKRTNICLTCARLKNCCQSCMLDLSFGLPLQVRDAALKLVAPGPTSGINREYYAQEHEKELEEGRGAVEVYDKTDERARDLLRRLAKSEPYYKKQRRLEAEGSSEKALEQKPSGYGPVRTSDSRKAANAQRGPRPGAGRAVAGAARPPQPEDYLPPADPNITSLFVTGVEDDLPEHAIRSFFTPFGQIRSIVCSHRAHCAFINYATREGAEAAAAQCQGKAVIQGCPLRVRWGKPKPLDNADREQRLEWAREGRQTASTTPNAQSGSQGVSGSEGARALEGPSAEEGASFTLAAPPGQGEVSYASLAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKF7</accession>
    <name>A0A0D2BKF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NmrA-like family domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03703</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239624.1">
        <property type="nucleotide sequence ID" value="XM_016378054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKF7"/>
    <dbReference type="STRING" id="91928.A0A0D2BKF7"/>
    <dbReference type="GeneID" id="27330786"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03703"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_1_1"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000181">
        <property type="entry name" value="NmrA-like family domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="8">
        <location>
            <begin position="3"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="301" mass="33263" checksum="B135BD054BBDA39C" modified="2015-04-29" version="1">MSRIITVFGATGNQGGSVIKHLLADSQLSRQFKIRAVTRDLAKPAAQALAKQGVSLVKADLNSRVSISEAIKGSDTVFLVTNYWESADPSVERTQGKTVADVAKDLGVSHLIFSSLLNVTETSGGKLKNVPHFDSKADVEKYIRSLGIPATFVLAGYFMSNYTTMLQKQDDGSYSLAYPVGRETRFPLFEPAEDTGKFVKVALKHPEAYRGKQVLMAADYYTVDRITSDFEEATGKRLNFLQVSAEQYKSFLPKAIADEMLENHLFVENPGYYNGASLKESLDALEDKPTTWKEYAKKTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKV1</accession>
    <name>A0A0D2BKV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenine deaminase</fullName>
            <shortName evidence="4">ADE</shortName>
            <ecNumber evidence="4">3.5.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Adenine aminohydrolase</fullName>
            <shortName evidence="4">AAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AAH1</name>
        <name evidence="6" type="ORF">PV08_03524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenine + H2O + H(+) = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="4"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239446.1">
        <property type="nucleotide sequence ID" value="XM_016377876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKV1"/>
    <dbReference type="STRING" id="91928.A0A0D2BKV1"/>
    <dbReference type="GeneID" id="27330607"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03524"/>
    <dbReference type="HOGENOM" id="CLU_039228_7_0_1"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF7">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW19230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="363" mass="40544" checksum="7683DB37DD63CBB3" modified="2015-04-29" version="1">MSSDPAAPQVQDGDDIRTFIEGMPKCELHVHLEGCLTPSLARRLAERNNLPLPPSLSSLDPSQTGYSFHDLTSFLAVYYPNLSVLQTEHDFRDLALDYLTRAHAQNVKHVELFFDPQAHTSRGVPFPTVIRGYRLGLLTAQRTLGISASLILCFLRDQSPEYAMATLMEALPYKDAVIGVGLDSDERDNPPSKFAAVFQRASKEGFLLTAHCDIDQANSITHIRQCINEIQVDRIDHGTNIVEDDSLVDMIISKNIGLTCCPVSNSVVTADFKGREILTLLRRGVKVTINSDDPAYFRAYVNENVEKLARESDVTRKELIQLQRNAFAISWISSWRRNHFLALLDDYEAKMIQTPALVNGAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLF5</accession>
    <name>A0A0D2BLF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239621.1">
        <property type="nucleotide sequence ID" value="XM_016378051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLF5"/>
    <dbReference type="STRING" id="91928.A0A0D2BLF5"/>
    <dbReference type="GeneID" id="27330783"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03700"/>
    <dbReference type="HOGENOM" id="CLU_024395_0_1_1"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="142"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="562" mass="63116" checksum="9520B0498101F784" modified="2015-04-29" version="1">MDASSHATAQLLTECRKAAKEAKWDSALKLIERALRACGSTDSRTRITILDTRVAVRLRMSMPALALQDAKGMIRSDKSDGRGYVRCGQIEQEQGNAPAALKWYEQGLKHVQPTSQYFATISAEASKAQERIRVETMNSKPIDPMQTLPLELAERVLSFVSYKQHVRMLRVCKGWDKLLRSLRPLTDTLAFPSPSRDINSKMLHAALRRLKRPTAIHISRLQPAASEVLGDRMQYWQNWQRLAVLEVHDRRFASWNLPLPKFDLRTIKLQDHNAIPFSAVQQILRDCTHLETAMFSKVAYERSLAWENPPTLHGPELRSLQISVATSTAATILVNLSTMFARMSRLESLQLENIDGGRSVLELRHIENLRHLTLTGLSVGEIRLPPSLESLELYHSAAHPGDHTDPFSSTRLPHLGIFSVVDCSGLPRLLSKAIAAENIVQLTWVFARESEEGRFLKDLVDQGRLKGVRDLHLKIEDLCDSRSSTFVRGLPKLETLCVEEAMITGAFISDLIEGNGKLRKATLIQCPKVSGDIVPWSKARGVQVERVNSINASGRRVVEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLN1</accession>
    <name>A0A0D2BLN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_00428</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 17">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240069.1">
        <property type="nucleotide sequence ID" value="XM_016374793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLN1"/>
    <dbReference type="STRING" id="91928.A0A0D2BLN1"/>
    <dbReference type="GeneID" id="27327511"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00428"/>
    <dbReference type="HOGENOM" id="CLU_049331_1_0_1"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="67"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="211"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW19853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="248" mass="27990" checksum="B35E01896C42413C" modified="2015-04-29" version="1">MSSESPKVDDRENRIRSTALRHATEIEDRKKLQTRIADLIVEAFELPTKPDADPARPSPSDASLFKQCLGLFQQSDLDDLIYERNVDNRCGYALCPKPNQRLSHTGNLVWNRKGGKDFKLVNKAEMEKWCSSLCAERTAFVRTQLGTGPAWLRDITAVDIKLFDEFDTDHLAESLNALSVARTAEDEVAEKMQALALERGELKVNRNEEGVTLIEKSSDEIPEPPSLTSQQQGTIEGYQPRKVRFQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLV3</accession>
    <name>A0A0D2BLV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6 zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239746.1">
        <property type="nucleotide sequence ID" value="XM_016374470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLV3"/>
    <dbReference type="GeneID" id="27327185"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00102"/>
    <dbReference type="HOGENOM" id="CLU_024934_0_3_1"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35295" checksum="4E87EC6AA0FDD57C" modified="2015-04-29" version="1">MSSRISSHAVWRDTIFAEALRHDFLLHGLMATAALHKATMQAKTSDAYAEYSKVALAHQNAALAGYIPAVNKPNQNNGIALFCLSLYLTIWAFASKRLPEGLNSVKLDLNPGESPGIALPLHSPTADFIEIVMILRGIYAVIRETDTWLQGDIEELLRYPQPGDLPPHPADVSEAFNLLAEVADDPKLIPLLGGEDPAASRASYLEHLGRLRDISRCRSVVEWDGHIFSWFIMAPTTFIHSLKRGDPWTLILFAHWAGAFRCMDHHWWAVGWAYSLVVDLSALLDPVWRPYLEWPRRQMGLVFQDNALPDARRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMD2</accession>
    <name>A0A0D2BMD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240299.1">
        <property type="nucleotide sequence ID" value="XM_016375023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMD2"/>
    <dbReference type="STRING" id="91928.A0A0D2BMD2"/>
    <dbReference type="GeneID" id="27327741"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00658"/>
    <dbReference type="HOGENOM" id="CLU_056472_0_1_1"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="291" mass="31921" checksum="AF58D1872773DFA1" modified="2015-04-29" version="1">MSVTTQATIASFGGKLLKLAHQSPTLGCEMKFNLYLPPQATQNSLHKVPLLIWLSGLTCTGDNCSEKGFFQHGASKKGIAVLYPDTSPRGIGIKGEDDSYDFGSGAGFYVDATAEPWSNNYKMYTYITKELPETVFSAFADQIDSSRVSISGHSMGGHGALSLYLKNPGKYKSVSAFAPIANPLKCPWGEKAFKGYFGESDWQKKGAEHDSTELLKRWKGGDLDILVDVGTGDNFHKQGQLLPENFIAAAKEIGQEKGLNVRFQPDYDHSYYTMATFSDDHIDHAAKYLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQB0</accession>
    <name>A0A0D2BQB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_08507</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233535.1">
        <property type="nucleotide sequence ID" value="XM_016382832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQB0"/>
    <dbReference type="STRING" id="91928.A0A0D2BQB0"/>
    <dbReference type="GeneID" id="27335590"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08507"/>
    <dbReference type="HOGENOM" id="CLU_013325_9_3_1"/>
    <dbReference type="OrthoDB" id="10265862at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000125">
        <property type="entry name" value="tRNA threonylcarbamoyladenosine dehydratase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="13">
        <location>
            <begin position="103"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW13319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="514" mass="57345" checksum="54735D65D8F24367" modified="2015-04-29" version="1">MSQWVQRHASTTVQLSVAAALGAIAATSIIFTATSIRRRRITEELKASIPELSREHHATQLTEYGGALRPSITDKEDERSAKIAARARKGEYDEELILEQLARNRVFLKDEGLAKLRDAFVVVVGLGGVGSHCVAALARSGVSRIRIIDFDQVTLSSLNRHALATLADVGTPKVHCVRKRLEQICPWTRIDCRNELLGSNTTEALLAKWDYEVRDGEDCKEPDWVVDAIDNIDSKVGLLHYCAMKGIKVISSMGAGCKSDPTRIQVGDISTSTDDPLSKSTRRRLRMKGVKDGIPVVFSTEKPGEGKAELLPIADEEYNKGNVDKLGVLPDFRVRILPVLGTMPAVFGYTVANHVICSIAGYPMDYRVGDKGREKMYEGILAGLQAVEERLVRTTDGQVTVGLRIPVSRDDVAYLVEEVFRGKSVVSGLISRLALIRWRKPEGGFRIDESYLKEGQKMIKLPIADLVLMTREEAQRHEKEILRGSTAPEDYYEPEVVNTVERRRREQISYERYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQU6</accession>
    <name>A0A0D2BQU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adhesin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241061.1">
        <property type="nucleotide sequence ID" value="XM_016375785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQU6"/>
    <dbReference type="GeneID" id="27328506"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01423"/>
    <dbReference type="HOGENOM" id="CLU_648959_0_0_1"/>
    <dbReference type="OrthoDB" id="3539644at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="47268" checksum="D1974E668A72ACB4" modified="2015-04-29" version="1">MSPTACHCPHEKTPLIEVLPVPVIATRQKKRPSCCHRLFKVVIALFGALFVLDLLSHGPVYRRLRNNYHGFVDSLPDSFADLYVDALVSGGGEGGQPKHPVPPMDDWTPFEGTTHFEIEPRAASGLAVHGDKAFGKVVFETSKLSDKVVIDLDIKTNKLDKHGDVIVEEKNGHLTIRTPDAGKLETYASAKIQIPSNILGTFGMRHFDIDVPAHMVDYSALPKSLEIGDFAIRVAKGFVKPGPVHTNRTAISIADGAVRGSLTHGRQHTEIDVAKGNATVDIPRISAGNEGSTHIHIGNGHLNGTLAVYNSTSVDVGFGSIWIDVDFKDTEHRAHLSTKIVSGPSRVFVDSLPPDRLFRSEHLTVAGDQLITYPSSFEGTIDARGFAGDIKLTGDDLDVEEVVGGAVGRKGDWDRNYMSVKAVKGALDILVGDDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR33</accession>
    <name>A0A0D2BR33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241674.1">
        <property type="nucleotide sequence ID" value="XM_016376398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR33"/>
    <dbReference type="STRING" id="91928.A0A0D2BR33"/>
    <dbReference type="GeneID" id="27329121"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02038"/>
    <dbReference type="HOGENOM" id="CLU_057565_0_0_1"/>
    <dbReference type="OrthoDB" id="4001642at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="185"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="401" mass="44367" checksum="66C618725D8B5BA8" modified="2015-04-29" version="1">MSAFVRVTGRPNTNFLVGYPGISATLPRIEGTVELRPGVGISSPVNISVVTIALQRRESIHPHADSVAKKHLAAPRKESTETVGKEMLLFRCPANREYEEIMYMDLPFVIFVPFGRGGQETARRVPPASLQLSRRTAETYYEMVVTVGYGSGDRKQYAFPVPISRYDTLSTFGMYNRPESAERVSDHLVTLGISLPRWSYGPLDPVSVYIKLSPNPDWLSKARKVTIRKIEIGIDEEVIYNHEGDEPQRKTKNLVRKTENVGVKMPEAGYFTNLGLVFPANDLRDADGIMPRGRAAFPQYAVTGFTTTAGLYKVEYYLTIKASMNGAKDIVLRQPIVVCPYDHAMCKAEMEAIEQAARDASHVNADNPMLPLATIVRASDPNAMSCIGVALVGSVKKPLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRB5</accession>
    <name>A0A0D2BRB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241804.1">
        <property type="nucleotide sequence ID" value="XM_016376528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRB5"/>
    <dbReference type="STRING" id="91928.A0A0D2BRB5"/>
    <dbReference type="GeneID" id="27329251"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02168"/>
    <dbReference type="HOGENOM" id="CLU_009375_1_0_1"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="571"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="638" mass="71906" checksum="5B328DED9DFF2EDE" modified="2015-04-29" version="1">MDDHEHDPPQATPKVRNEKPFFYPWNRRLRHLHGISLRNLHVTAPSPRKHAKTITDDDAPYNLTSPSKRALKSDAQSLPQSRSFTNLISVTGEAHTPNAFHKAATSYEKNEKQTDRPRAGRMRRRSTLHWTSASPRARQSKLEDMVVDRLADSWISIHSPDSTEPVYISEVIERSMNPSFAFFDLDNTDSQVARSDEGTIRVWAKASNADEYCLLVELALNLRSLQFIGRTLENFHHPLPQNCVLLHLSDGIYTSFTDLPADVRSGSDHLIDHKEGSARPGVSFDVLMQLANLDECIQDAINVRTQLEEDINKLIADSHLFSVNDEGPSRLESDEPRAEAALASEQKHLRQLTKRRDEKQESLTKRRNALSLCREELTKTRKSIEDRTKSCQEIESLLQQTDKDSTGQVRRICEALLTIYPIEPIKGRTLQFTIRGIHLPNSVYNDTNRDEIAAALGFSAQLVHHLSLYLSVPLPYPIEPYGSSSFISDPISIGLSQRRYPLHPTTVPYKFEYGVFLLNKDIEFLMNRAQLRVLDIRHTLPNLKYLLYVLTAGTGDLPPRTGGIRGLLGGRMGPEPLRRDSEESVQSLPSALGADSNQGRINGGFASPKEKDINDRFVSTSPALGVSYRHGFKDTTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRQ4</accession>
    <name>A0A0D2BRQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">D-xylulose reductase</fullName>
            <ecNumber evidence="9 11">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_06690</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 11">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 11">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9 11"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234125.1">
        <property type="nucleotide sequence ID" value="XM_016381023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRQ4"/>
    <dbReference type="STRING" id="91928.A0A0D2BRQ4"/>
    <dbReference type="GeneID" id="27333773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06690"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="13"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW13909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="367" mass="39062" checksum="CCCE6D5C793931F0" modified="2015-04-29" version="1">MASSRNPAVFLYGPGKARIEDTPEPRITEPTDAIVRIKYVGVCGSDVHFWNHGGINGKYVSETLPLIMGHEASGTVHAVGAAVTHIKPGDNVAIEPGRPCRSCTRCKEGLYNLCPSMKFAACPPDTPGCLAKYYKIPADFCYKLAPGVSLQEGVLAEPLAVAAHAVRMVNVKPGQSVVVFGSGTIGLVCGAVARTFGAKKVIAVDILDHKLDFARRLSNAATFKPDVGASAEENAARIVEENNLGLGADAVIEASGAESSVNTAIHVLRPGGAFVQTGLGKPVISFPIVAMSEKELHMHGAFRYNTGDFRVALDVLESGAFPLKSLITKVFDFEQTTDAWEETKHGRGIKNMIRGYGLNDHSRAAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRW6</accession>
    <name>A0A0D2BRW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234175.1">
        <property type="nucleotide sequence ID" value="XM_016381073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRW6"/>
    <dbReference type="STRING" id="91928.A0A0D2BRW6"/>
    <dbReference type="GeneID" id="27333823"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06740"/>
    <dbReference type="HOGENOM" id="CLU_017594_4_0_1"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.180:FF:000003">
        <property type="entry name" value="Type I phosphodiesterase/nucleotide pyrophosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="701" mass="77747" checksum="F593603B839D37E7" modified="2015-04-29" version="1">MARTRDGLLSEKRYDDDAATLVPSDEGSEDESDGSAGGADTVQDGDRDILDETEEHENLLRKPGKLDAVRELAGIRGSKQNGARKTGRRKDRLKSYGRRAKGESDTMFEMEGGFKDTSSQSSTDSEIEGTKWDRRAPAKSHRGRLTLLLLAIIALFVSLVFGAYKASHKHTLAPTVHRLTRLSNGTHTFRPTTILISLDGFRADFLNRGLTPALNAFVASGVSPKYMLPSFPSVTFPNHFTLVTGLYPESHGIVSNQFWDPDFQEEFYYTNVGVSMQPKWWTAEPIWVTAEHHGVRSAIHMWPGSEAHIPDVEPTYLDKYNGSEDLTRKVDRMLHWLDLPGDDDGGDDVTEKRPQLIAAYVPNVDADGHKYGPNSTEIRATIADVDSMFVSLVEGLYARNLSEIVNLVVVSDHGMATTSNDRLVQLDDLMDMSLVDHIDGWPLRGLRLKNPDRDVPILYEQLSKEAAKAGSFDVYTLETMPERYHFSNNDRIAPLWIVPKTGWAIVEKSGFDVAEAQKTGQEYQPKGLHGYDHEHPLMRAIFVARGPAFPHKPNSRLAPFQNTEVYNIVCDSLGIEPHPNNGTLRLPLKPEGLHSDADAPVVDIPADPIDQGENVADPEPEKPQDSPPQEHEEDPVDATDPVGGTDPEQSDDPSDDGGGADDAKSKWWKFLHEGLQKAKDWAKQFVESIRGNKKGEGDPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BS77</accession>
    <name>A0A0D2BS77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_01870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241506.1">
        <property type="nucleotide sequence ID" value="XM_016376230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BS77"/>
    <dbReference type="STRING" id="91928.A0A0D2BS77"/>
    <dbReference type="GeneID" id="27328953"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01870"/>
    <dbReference type="HOGENOM" id="CLU_016972_4_3_1"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239291" description="endo-1,3(4)-beta-glucanase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="8">
        <location>
            <begin position="15"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW21290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="492" mass="51243" checksum="1A10B244661B75CC" modified="2015-04-29" version="1">MLSRSVLALAGFISLSTAGYVLEDDYSGDQFFSMFDFFTDRDPTNGYVTYVDQTTAQSNNLIGTNNGSVYIGVDHTNVASGLGRSSVRLTSTKTYTHGLIILDLNHMPGGICGTWPAFWTVGADWPNNGEIDIIEGVNSQVGDAMTLHTREGCSISSSGNFSGYALTTDCYVDAEGQASNAGCQILDSNDPASYGTPFNEGQGGVFVTEWTSAAIKNWFFPRGSEPWDIASGSPDPSSGSWGTPVASFSGGCDIDSFFSNHQIVFDTTFCGDWAGNVWSTDSVCSSKASTCEDFVQNNPSAFADTYWSVNSLKVYQNPFGSSSNGTTHGPPSPSIPVSIPPWSSAVSGGWPSAAASTATATATASDAPTAGFSRGGNGRFTKTWGGNNGDGGAGAFAATSTAADASQPEITSGPSLGGGDGGSFATDYTTVTALTYGDFSGRQGQKVKRDASPGVGEIDQVRGHMQTHRKVHRHLFKHVGLAGMGPGSAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSH9</accession>
    <name>A0A0D2BSH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_01965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241601.1">
        <property type="nucleotide sequence ID" value="XM_016376325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSH9"/>
    <dbReference type="STRING" id="91928.A0A0D2BSH9"/>
    <dbReference type="GeneID" id="27329048"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01965"/>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="134"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW21385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="329" mass="37362" checksum="3B65E5474C33D4EE" modified="2015-04-29" version="1">MDSKMDVDVGKPAQPHGLSAVTDSQSIPTLDGWIESLMDCKQLAESDVSRLCDRAREVLQEESNVQPVKCPVTVCGDIHGQFHDLMELFRIGGPNPDTNYLFMGDYVDRGYYSVETVTLLVALKIRYPSRITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALIDNQIFCLHGGLSPSIDTLDNIRSLDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHNNGLTLVARAHQLVMEGYNWSQDRNVVTIFSAPNYCYRCGNQAAIMEIDEHLKYTFLQFDPCPRAGEPMVSRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSL2</accession>
    <name>A0A0D2BSL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234480.1">
        <property type="nucleotide sequence ID" value="XM_016381378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSL2"/>
    <dbReference type="GeneID" id="27334129"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07046"/>
    <dbReference type="HOGENOM" id="CLU_006937_6_2_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF2">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="76363" checksum="9E5DCEFD361A877A" modified="2015-04-29" version="1">MAYHSETNGVATSATKGTPNGPIKGVGVTVPEPTAHVGDAQSLKDASTTLKPLPAYTPRRLRVVTIGAGYSGLTLAHKFQHQHPDLADLINHTIYEVRPELGGTWLVNTYPGVVCDVPSHIYAFPFDPNPSWTRFFSTGPEIWEYMKKTAQKWNLERDVKYNHRVTGAYWQEDRGQWQIMVEHNGTIIEDYADIFISAQGFLNTWRWPSIPGLSQFTGKKVHSASWDHDYDYSNKRIAVIGNGSSGIQILPQLAKLQGTKVASFQRGPTWVVSTMNPASLLGKDDPAYNPVYTEEEKQEFLDNPRRHHEYRKKIIHGINDSFKMFVKGSELNQQIYHLARTQMTSKLQNNPRLCELLIPKWEVGCRRITPGEGYLESFLRDNVQLTQSPITHIDADSVVTADGKMYKVDVVVCATGFDVSYRPQYPVVGRNSVNLQDKWAEEPSSYFSLASADMPNYFMFTGPNALIGHGSLMESLGWSAEYMIKWIRKIASEDIKAVVPKQSAVNEFIVYSDQIHKTLTWTGACRSWYKNNTVDGRVTATFAGSALLFKRLIQDLRPEDFEIVPRDKNRFRFLGNGFLEYELQSGNDLAWHVERAAAEAYDVDESTFLNRMNGIKPRNETRTANHTLTLEEEQTLVEWILDLDTKDYLPNQSSATQVAEFLLGQRTTRLFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BTF5</accession>
    <name>A0A0D2BTF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234715.1">
        <property type="nucleotide sequence ID" value="XM_016381613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BTF5"/>
    <dbReference type="STRING" id="91928.A0A0D2BTF5"/>
    <dbReference type="GeneID" id="27334366"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07283"/>
    <dbReference type="HOGENOM" id="CLU_357880_0_0_1"/>
    <dbReference type="OrthoDB" id="4161349at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="824" mass="92921" checksum="BC46413A0DC11175" modified="2015-04-29" version="1">MRRSARLSAISGSETLQNVQEPEDSLHDVTAILNAEASNSNRTPTSKRKRNATKQVHHGESPSKRREVQDVRASTLAKSPSRPSTIRSSGKLKARPSLALRPLPSKRDAYDLPESPTDGPEPKNLMSPPVKMRVLNKRKQLPVSPFRGRGEFDTRSTATVYLDDSPRKAVTKNTLQKIGSSFLNLKPPARQQASTDIPFNGDVFAEALVASDGPDTPILLPSQVNKLASTEADSRTPVKRRIAQPLSGQVKAAARNGPPSSTEHDQEQISEKARVPNPLAHAVVATQTKSNSPRGRKKKSTLPDRSLTAGLAPKTPVREISSALHAPDASASDRRQNPGTSRPAALHDREVADDNDDTDNINNRNASDEEDPEQRGNEDGDDDSFGKATNCRPEAEDSYDQQGHQDDHDVQENRPKSRVQRPETEAERRRRKQLEAEEEDAEARRVRKAMNSINEAAEIFDCKLAWQTALVASAEITEERAYSELRSTNGKAIARSLRSLAEAYKELIRHGNNSDAGGSTATIQKDLQVYKQRCQHISECRHSPILDRHQDRRRERKHMIWDIYEHLVPDSLKLAKYVLRAQYQANHLNTAALREMIEVLKVTRLLANSATQWQPRPKVPVGIRRKVQLKVAQNVEHIIRQYQEKVSIEDQEIYRDELEIKQRADHERFLLEVQRRRAAVREKHLTYAARISREPVDQVVDVGDSNQDEPLYQHGQSRFSQPNVVGSPPDKAFTHREPTQESGRTAAKQWSSSELELLLNALQKYTSPTRFEDIIAAYGGYRGRLGKYNKDEIIAQARWVKKSILRESYDFYNGQWDWLLSLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BUG8</accession>
    <name>A0A0D2BUG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235115.1">
        <property type="nucleotide sequence ID" value="XM_016382013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BUG8"/>
    <dbReference type="GeneID" id="27334767"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07684"/>
    <dbReference type="HOGENOM" id="CLU_011915_2_0_1"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF28">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="189"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="569" mass="63558" checksum="E36B92E75E607EC3" modified="2015-04-29" version="1">MEKIHQSFQEVLNHVRPEMAVPTAPLQPLVAATLAPQGNGPDPEIWPSSQQIAEVPYFAPTPLMERLPGPLSVPAMEDASSGLPPTAVLHELVELFFELVHPWAPLFCKPNFTAGMFAPDRQVLLHGIVVVSFRFWRNPAPSAQEKDNFVKTSREQVLLKSVDTCSLVSTQALALLALDAIGQGPGPRTLNLMSMLITAAHQLGLAKTRSPTTPETNTPLVRNEEPLDGADFSNISKEEKRRLFWIIYSLDRFSSVAHGQSGGIDTKAIKLPYPLNDGEWNQTVTPEWFQAGQQTKPSHAYCSASLWHHNIDLLASLDRSNQLLIQPVDLSLPAHCQEWQSVFRRLDITMTTWFENLPKDVRERPATFDPMWVMLHATFQLVNIRMYTVAAFPSTTSPYLKPSASARGRCRQAIRTVASLASSLQPQEFDRLNPMFAFVVWVAARSLIILWTTGYENTFGSMPVDLEPLLSVLRQMSTRWMCAQRYADIIQLILDTKNNPGGPTGLEIFNDTRRTSYGLQNLLGTLVAHRAPESFSNSFDFLDMPLLDLGDFGPSRIGNFVTDNDGEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BYN4</accession>
    <name>A0A0D2BYN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06476</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236640.1">
        <property type="nucleotide sequence ID" value="XM_016380813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BYN4"/>
    <dbReference type="STRING" id="91928.A0A0D2BYN4"/>
    <dbReference type="GeneID" id="27333559"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06476"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_14_1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="4">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="378"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="911"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="977"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1043"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1109"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1181"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1211"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1271" mass="141458" checksum="9F95F1CDBF1155DE" modified="2015-04-29" version="1">MRLLTWGSENELVLTDHRNENIPPYAILSHTWGLEHDEVTFGDIQNREGRSKSGYAKILFCGEQARKEKIKHFWVDTCCIDKTTIELSEAITSMFRWYQQATKCYVYLSDVTVPESGKIGNEQSTWELDFRNSRWFTRGWTLQELLAPANVEFFSQEGEFLGTKQTLAHQIHEVTTIPLAALCGTSLDQFPVVEKIRWTEGRETTKREDGAYCLLGIFGVYMSLNYGEGDNAFSRLRRKIDKRHGSNVAARLDAVEKVWSSGPCDSPAPCNNIADLLGRASDSDQRPQTGQPSMLRPAKRARTSYNTNFFGSSDTLPHENTVVSHRASTSSHTQHSEQSSRDVSRIMSEDKYNSLLKSLLFERIDFRVNNVRKALLSTCQWLFHHPHFQTWYEGDSSAQHSGFLWIKGKPGCGKSTLMKVLLEWARKRKSKDRGRQSVVPYFFNARASASLEKSSLGLYRTVVHHLLSSCPKLGILFAEKFAFKDPGQLGEQWSVEELQEFLMDAVESNESFGLCLLIDALDEAEYEDDVRDMIRFLIQLSDRASASDSSCKLRICLSSRHYPHINITKGLSLVVEDQLEHGQDINYYITKELTCNDGDEKDELRVEILNKSAGIFLWVVLVVKILNTLDDRGASLSDMKTCLKTIPANLKELFREILKKGGDEIGKSVLLFQWMLFSLRPLQPAELIVAMQYSEPLDDQHSPLAMDISIPDPERLARSILNHSRGLVEVIQDGPSQTVTVQFIHETVREFLLKENGLASISQALAANVEGTSHQVLRIACHRRISTTDIPKEFEHYCEASHRTNASLDIFKSTMRLKWPFLDYAIAYLLEHAEQAQKRDISQQDFLKSQIGANGLWLDHYRLWWNALERYKTKKVKPNVTLIYFVAERKYSHLLTALLNLSDAINTPCGRYGSALQISSYYGSQEMVKILLDKGADVNTQGGEFGNALQAALENGHEKVVQILLDYSTDANAQGGRYNSPLYTASCRGYTKIVQILLEKGADINAQGGLYSNALQAASACNHEKIVQILLEKGADINAQGGRYGNALQAALVRDHKKIVQILLEKGADINAQGGYYGNALQAALVCDHEKTVQILLEKGADINAQGGLYSNALQAASACNHEKIVQILLEKGADINAQGGRYGNALQAALAASAGGYEKIVQILLEKGANINAQGGLYGNALQAASAGGYEKMVQILLENGADINAQGGRFGNALQAASAGGYEKTVQILLEKGADINAQGGLYGNALQAAEARGHEQVVHLLTGFRTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C1C4</accession>
    <name>A0A0D2C1C4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_04678</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237700.1">
        <property type="nucleotide sequence ID" value="XM_016379023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C1C4"/>
    <dbReference type="STRING" id="91928.A0A0D2C1C4"/>
    <dbReference type="GeneID" id="27331761"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04678"/>
    <dbReference type="HOGENOM" id="CLU_012353_1_0_1"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="693"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="698"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="716"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW17484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="752" mass="84484" checksum="4790F2019306CB54" modified="2015-04-29" version="1">MSKVVSESEPATNEVSHPDQRTTPASFRVVVPTSLVFDVRAVFLTLVGFRLLNALTIRTFFQPDEYFQALEPAWRWAFGEDAGAWITWEWNSHLRSALHPAAFGMFYQTASFLAEALSLDSHTRSELLLATPKVMQAFLAAGGDYFTWKLGSYIYGNDTVSSLMVLLLNVISPWQWFCSTRTFSNSVESTLTIVALYNWPWHWMQPLTTEGQRDSNTDSKGLRVRGSNSEEQADSADEMTRLRRALLCAAAATILRPTNLFIWFSLASMGFFRFWKSAGPSWTELVTFIRETILCGSIVLLFSSLVDRLFYDEWVLPPLKFLYVNVIQSLATFYGSNDWHYYLSQGYPLLLMTALPFTLISMYRVLCNRVAESEATPTGLGTLKPLTMLCVLVPALFSNIAHKEVRFIYPLLPALHIISALQFSRVFGCLVTGSSRSGRASKQLLLAVLLALNACIAYYSSYVHNSGIIDLTHYLRHEFEHAYLPMSPASNMTTGMLMPCHSTPWRSHFQYPPTAAHPGILAWALTCEPPLGLNATEKAAYMDEADQFYDNPTLWLKRHMSRRPPRRKDGVRARGDAAGVFAPLDASSASRKRTGVSSDSIDAERDKHYWNTGEGRKPWPDYLVAFAHLEPTMTVALRGSGYVECKRLWNSHWHDDWRRTGDVVVWCLDGSRAANSKSAGENAVLHETGNLENAIHDGAGGQSEGGQKVLGGRQGESPKSKGEKVTEKRVKNPVKRVVEKPFWKIRDPELEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3E2</accession>
    <name>A0A0D2C3E2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Benzoate 4-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238350.1">
        <property type="nucleotide sequence ID" value="XM_016376780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3E2"/>
    <dbReference type="STRING" id="91928.A0A0D2C3E2"/>
    <dbReference type="GeneID" id="27329505"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02422"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239458" description="Benzoate 4-monooxygenase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="55322" checksum="AFB85E553285C201" modified="2015-04-29" version="1">MLLICILLYPILQPIYAYFRDASGLRQFPAPSYAGLSSLWRIGHAIRKKHYLAVHNAHKALGTHVRIAPNHISICDPAAMTEIYGHGTNMLKEGWYDGGAGVYRNMGDTRDKAEHQSKRKKFAHVFAQKTIVGLEPVVHSMVQTLNSEIDKRAASGETINVRRYLNYFTIDLISKLLFGESLGCMTRGNDTVSAETKDGKVYETTLIDALHLSMSINTPLGMEAPLLPYTTRLFAFHPYRRAGARFEDIVYHNTMKRLRKTEDQDDFFAKLLVNNKGEELNLELGEILAESGVIMNAGSDTTTSALTSTVFLLYKHPQVLAKLRKELDANLGDVAIPAYEAVANLTYLRACIEESLRLRPAQSIGLPRTVPAGGRTIAGRFIEEGVTVSVPTYTLLRDPRAFDEPETYNPDRWMTGDKEKMARYHLPFSVGPRACIGRNIAYFEQLIVIADLVKNYDFELLSSDFELENFERLNSNPGELPMRVRRRINNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C929</accession>
    <name>A0A0D2C929_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240255.1">
        <property type="nucleotide sequence ID" value="XM_016374979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C929"/>
    <dbReference type="STRING" id="91928.A0A0D2C929"/>
    <dbReference type="GeneID" id="27327697"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00614"/>
    <dbReference type="HOGENOM" id="CLU_007426_0_2_1"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="871"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="627"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="871"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="889"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="927" mass="101555" checksum="D1BCAED5C964BFE8" modified="2015-04-29" version="1">MTPTPPSGHSSHSGASPDQFRVVRKRNRIPLSCAPCRHRKLKCNRQQPCDNCTKRGDNTSCTYAAPATRKKGSSSHSASNSTPDDMQNRIDRLEGLVLSLMTSGSQSVGPAAVQQALSAGTSVIGSGSLGPPLDSELDETTMMDDGDNQEAESETDGVTQSFGILKVDSEKQKTFYVGEAHWAALLSEIGEVKNYFNAHKKEYEAQMEKVEQARKAMGTDAGAGPALLFGSTVPPSRAEILAQIPSRYMSDILIGRYFNTFDPSTHILHGPTFQRHYNQHWQDPSKSSIVWVAMLFAMMRLAMLSYGREGDEPPEFRGKCQDYSANFRTQMAHCLITADYTKPHNYIIETLIFHLHAEHTSNRDSEASVWVLVGMIARLAMRMGYHRDAKLFPNLTPFQGEMRRRIWTFVRTADLLFSFQVALPSMIRIGDSDTDLPRNIYDDEFDEDSTSLPPARPASEATPISYMIAKGRLSFGFGRVLEEVNGVNKKGYDEVLKIDSGLRDIYESIPDHLKIRPMPEQTLAPISLIMARFSLASVYHKSQCVLHRRYMRLARPGNRYVHSRRMCLDSAMQLLSFQAIQHQQSRERGRLRSLRNHVNSLTAHDYLLAATVVCMDLYNHRERGDNDVSTPSTSVSGGSVSQGSNNSDGGAYVQGLNYTRDDLIRALEESRDVWMANRDLSMEAYKASELLNVLLYYIKSPYSPSNPGTSQLPATAQPTPGSSNDEQNAAMTLGMLQAGGLASGQSGGVAQAPSPGSQFDKMGLNGVLGASSDLTGAGIFGTGAANAASPFPAAFFNGMGDFGQNMNLDWEAWDQYMQPQSLSLDPAANLWSSNSPSNNLFTQSPDAANDMSFGMSGASSFYAPNTISSVMSGSTDPKSNDQMPNLTANSTSPPSTDNNSGEVFMGVSTPQPGGIPSWKWTVMSDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C933</accession>
    <name>A0A0D2C933_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_00619</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240260.1">
        <property type="nucleotide sequence ID" value="XM_016374984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C933"/>
    <dbReference type="STRING" id="91928.A0A0D2C933"/>
    <dbReference type="GeneID" id="27327702"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00619"/>
    <dbReference type="HOGENOM" id="CLU_003818_0_0_1"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW20044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="583" mass="65114" checksum="092303C3FAA50604" modified="2015-04-29" version="1">MAGPARATGGRRLCNCITLIAVSVTTLLLFRPIVSFVLPLNIDSPLQTTIVPSSFNWAALRPYHPPTSTTPLPSGRFHSFSVQHDFEPESRSDTSKRLSRRKAVESAFNKCWKSYKAHAWLRDELEPLSASGKDTYGGWAATLVDSLDTLWIMDLKSEFREAAKAVAVLDWANTTGTACNMFETNIRYLGGLLAAFDLSQEPVLLAKAVELGDMLYAGFDTPNRIPPFWLNFEQAKQGSLIAETHQISASVGSFSLEFTRLSQITGDSKYYSAVAHLTSVFAESQNSTAMPGMWPTFIDARNARFDENSFTLGALADSLYEYLPKMYSLMGGQEQIYEKMYLDAMDAVKKYLLFRPTTPDNRDILFSGSATVSQGVVTLGHEGQHLSCFAGGMFILGGKLFSRPDHLDIGARLTHGCAYAYEAFPTGIMPEIFDMMHCASLDGCEWDERRWQNQGNLDLPRGFARVRSASYILRPEAIESIFILYRTTGDTKLQDLAWRMFQSIQKATETPYGNAGIEDVNAVGGEIKQKNSMESFWLAETLKYFYLIFSEPDLINLDDYVLNTEAHPLRRPVPHPSSRVSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C986</accession>
    <name>A0A0D2C986_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240350.1">
        <property type="nucleotide sequence ID" value="XM_016375074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C986"/>
    <dbReference type="STRING" id="91928.A0A0D2C986"/>
    <dbReference type="GeneID" id="27327792"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00709"/>
    <dbReference type="HOGENOM" id="CLU_026209_5_1_1"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="28"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="318" mass="34188" checksum="D28C19A5B2AFDA07" modified="2015-04-29" version="1">MTVTSEAEFATKDGTKLYTKSWKPDSGNTSAVLMFLHGFSDHINAYYDLFPTLSSAPFNIAVYGFDQRGWGRSVHKTSDQGLTGPTSLVISDIHDFILHVSGLDETHNKPLFLMGHSMGGNELLTYMLSTSSAYSNRPPISGVLLEAPYIELDPSEQPNAVTVVAGKMAASLLPHMQLKRALNAAFLSRSTTVQRDFINDSLCHDTGTLEGLKGLLQRAGDLSALSHGRKVSGLTTKVPCPVLVSHGTDDKIISFPAAERLFSVLDAPGGDKVFQAYKGGYHKLHAEPEGGAEQFANDVGNWILAHANHSSSGTQVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C9A1</accession>
    <name>A0A0D2C9A1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240375.1">
        <property type="nucleotide sequence ID" value="XM_016375099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C9A1"/>
    <dbReference type="STRING" id="91928.A0A0D2C9A1"/>
    <dbReference type="GeneID" id="27327817"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00734"/>
    <dbReference type="HOGENOM" id="CLU_122021_1_0_1"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="132" mass="14918" checksum="80BFEB37A93274B9" modified="2015-04-29" version="1">MSGYPKVTRENKSSYLSSFVRWLQLKKYQYEVTFSLYMLTPTEKFVFNFILFMLVSLLVTAAYYYLPDHVFLIYNRVWYYLQGELAYSAVAGGGGNKSLYLTEGSRRTADALTALTSPGSLVGSVTAVAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCB6</accession>
    <name>A0A0D2CCB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_01709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241345.1">
        <property type="nucleotide sequence ID" value="XM_016376069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCB6"/>
    <dbReference type="STRING" id="91928.A0A0D2CCB6"/>
    <dbReference type="GeneID" id="27328792"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01709"/>
    <dbReference type="HOGENOM" id="CLU_012358_11_1_1"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF37">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="63"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="478" mass="53449" checksum="0EB3EEE862074389" modified="2015-04-29" version="1">MHTKILKNGTVLAFDDASATIKVLPQADVIIQGDRIAAILEPHQEADAGVLSNADVVDVSGHIISPGFVNTHAHTWQTAYRTLGPDTTLAEYFGWVSQMSPKIGEWTAEDIYVSTLEGYLEGINAGVTSYVEHAHCNWGESAMKAAFKGAVDSGVRVWWCYHPLPREDFDVIKQIDILRELKAQSSQTNDLIRMGLAVDGLDHMSDGQIQQTRQVVVDLEAEVLTSHYLGKPWPFAIGLPEIAAKHEFHKLRAPFIYSHAGFLTEKDQELLRLHDQYVSITPESEMHYGHGQDTSRLIHDQASIGIDTNWTFSNDILLQARLWLQNMRGHISTDILKRGNIPKQNPMSVVEGFLLATRNGGRSLRRDDVGVLRVGAKADIVCFDGNSVNMLGWTDPVAAVLLHSNIGDIKHVMIGGQFRKKDGQMILKIGDWDDISERFKQTSQRIQEVFREPPPLPSQIWDKYTFEDVKVGTAKLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCG6</accession>
    <name>A0A0D2CCG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241410.1">
        <property type="nucleotide sequence ID" value="XM_016376134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCG6"/>
    <dbReference type="STRING" id="91928.A0A0D2CCG6"/>
    <dbReference type="GeneID" id="27328857"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01774"/>
    <dbReference type="HOGENOM" id="CLU_076687_1_1_1"/>
    <dbReference type="OrthoDB" id="5854584at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039632">
        <property type="entry name" value="TMEM42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28141" checksum="CF93BEE370A6148F" modified="2015-04-29" version="1">MTQRRRRAPKTASQSQTQSQPPSPSLQVPSLSPASRSSVPAAMDSDSRLFSALRRQPVWIVLAVSSGACAAINGVFAKLTTTALTSTLSSHIATFFSLSPSNKVVEFLVRGTFFLLNLAFNAAMWALFTAALTRGDSTTRVSIVNVSANFVITAVLGWMVFGEKLSGLWFLGAALLAVGNVVIGRREEGKKPGGTIGLDETRDEAIRQSEDDGEEEEEAARLLGRDAVELDDELGGGRRRRSSEEETRNTLKRGVEVDDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CDM7</accession>
    <name>A0A0D2CDM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241860.1">
        <property type="nucleotide sequence ID" value="XM_016376584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CDM7"/>
    <dbReference type="STRING" id="91928.A0A0D2CDM7"/>
    <dbReference type="ESTHER" id="9euro-a0a0d2cdm7">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="27329307"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02224"/>
    <dbReference type="HOGENOM" id="CLU_006586_14_1_1"/>
    <dbReference type="OrthoDB" id="4137226at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="11"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="540" mass="59677" checksum="2187619E89FBDD1D" modified="2015-04-29" version="1">MASEVFVHPALGTLVGISRGDDIVQFRGIPYAEVPARFRQSILRPRLPKEPFDARQPGPSCPQTTTLPFPQYWTGPLPPDGVKLDRPKTDEFNCLNLNLTIPRAGIIGTQKLPVLVYIHGGGFMVGSCSAQIAGREVWDATDLVRRSLTTGKPIIVVSINYRHGPLGFLASNELTEFNRQHGEAVGNYGLHDQRQALEWVSRFITGFGGDADNVTIDGGSAGAVSCHFQTFFPHRKFKRAMLFSGTCLALAAMRLEWHQKIFNTFAQRFPGAGSPVERLQKVSPDVLTHDVVGVWYTPLIDGEWIAGRTLAELKSIEVPPEFLIGSCSFEQDLTLSILRPPPILSPTDADKFMRTTIISILSTLGLTTYPDTLLSQKVLELYSIAESESSPTKQFAAWAQFVAELVFRIPPYHVALNHTGSKTYVYEFQATSPFPGWDLGFGKAGHAVNELLQFNAGGDLVEQKHQAALSGAVQELQDVVVNFCQGQLRWEPFDTYNKERLGPVYTLTNYGRGRKYGSIGDVVGLDVLGRWKAILEVSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y447</accession>
    <name>A0A0D1Y447_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_12015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN847503">
        <property type="protein sequence ID" value="KIW09731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229947.1">
        <property type="nucleotide sequence ID" value="XM_016386322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y447"/>
    <dbReference type="STRING" id="91928.A0A0D1Y447"/>
    <dbReference type="GeneID" id="27339098"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12015"/>
    <dbReference type="HOGENOM" id="CLU_003059_1_1_1"/>
    <dbReference type="OrthoDB" id="4145609at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF8">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="439"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="9">
        <location>
            <begin position="506"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW09731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="980" mass="109566" checksum="4BE674AE385A6660" modified="2015-04-29" version="1">MKLCNHHPWLRICDQGYETSLIDTGRLQTLGSRFEQPEDTCPSLIVLVGQQAKSVALEKLFDVPRSRLFKSKLYVGDIDLHVAPASPSSRRPILIATGSVGSERVRQTPNRHRCRDGSLWPLRTRPGGSKSHHMQRTEQAIYSRLLLPFTDVFCIFASDLGGIRGVASQLAGWLRDVTGPTSTPSTRPSVVVVTDKIPLTQMAETEAQKALLLLLKEETSQDPSVLFSFIEVVAVPPSQKFRGTAQGSMEHLKQQLLLRVRKAENCRREARTLYSLTHFTAFFESACEHFSASGSDPFDFIRASRSHNPLAEDHALHLTNFFKACDTARDLTNFAVPVIASSLMIDSYPPNCHLFDSVQVFQSLYRDALREALGGRVVSFEGSPDIILRSAVLKLIQGKLLQYFDSLVSGTELPSASLHLQVLQQFVKGWRRIRSDVTCLCCIRRPPQYRFPCGHCFCETCIQIFGKTQPTRPWTYQVSSCFLCKRVWDRDITVAVKPPTSGVSILSIDGGGTRAIIPLTVLRRLQDRIGLPIPIQKFFKVVGAVSSGSFVTLNMWNRGDSVEKSIQMLLQLAETAFEQDKPCKIPLISWLTKVAKWYVRDGRYRPDNLESILQSLLGRSTTMQDCSYATRLGTKLLVLAATVLKAPSCHLFTNYTKPRQNNLNPGKCQFPRKTRKARLWEIARAASAAPTFFPTKEVPQLGTFQDAGLLENDPVSTVVSEAKMLYPSSRTDFIVSLGTGTIPDVDVAQDAPTAKARKAPFRIQDLIWEKSRDKQVRQAFAHHPRYHRLDHEMDRDYALDDVNQMRKLPDRVEGDDSLTEQIDHLAHCAIASLFYFELSGMPSRRDGKFTGAGFLLCSIPGVDPAFKPLLTRLAAGRAQLYVNGQPMTCNWDDDTHRDENGNFSRRINYDTGDQISITICMGLSTPPGALISGLPSAVLDLASEQGLNACFGTSDHRKRKRVADDDVHVAKKKCRFHRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y5B0</accession>
    <name>A0A0D1Y5B0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230332.1">
        <property type="nucleotide sequence ID" value="XM_016385388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y5B0"/>
    <dbReference type="STRING" id="91928.A0A0D1Y5B0"/>
    <dbReference type="GeneID" id="27338159"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11076"/>
    <dbReference type="HOGENOM" id="CLU_001127_0_0_1"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="726"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="788"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="672"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW10116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115465" checksum="4E56FA7E3FB8213A" modified="2015-04-29" version="1">MAASEADQHRLNPRASLRNCSYIDPSTGARSNRTFTLRFHDADNHDFGSDTSDESTPLLPRASQYGSNGQRTKVGIVLHKSRDYAIRAKQFVVSETGKGVFKCALAYLLGSLATFVPALSQLFGRQSSKHMVATITVYFHPYRSFGSMLDALLLASIAFLYTAVVSLLSMTVAAFFADTVHLIELGHAIVLIFFVGGGLGLVAWIKLRKSDPLVNIACSLTSLGLINILTREGAVQAGDYSLRTIGSILEMIVAGVIATLLVSLLIFPISGRQKLRQNLLDVTDLQSDMLALITSSFISGDEGELENNVLSRVTEMHKKVSATVAQKLKEAKYEHYLLGTERQALIEARLAHCIQRISQNIGGLRSAAAMQFVVVKEPPFGSPMRTGGIAGAADAWDDSHKADRANGDVEGLFNNSKSIPASQGTEAALLHPNQEPFRSPAQIFELFIENLGPSMRSLAFTLKEILDHFPFDPDRNYAVSTIPKFKISLDRAIDLYKDSRQKSLAVVYGQKDMDRSRPLTVQADWEDAAAACGYFSFSLVEVAESVKDYLVVLDELQLEVDEQPAGKTWNWLKFWQEDVDHQELHGIHPELAEIVKKAGDLDLQFTQKPFDTSRHYNEAAWQDRPRIKRRLFHKIYDASAFLRREDIRFSLKVALGAVLYALPSFLPSTRPIYSHWRGEWGLLSYMLVCSMTIGASNTTGFSRILGTCLGAALAIAAWEVSDDNPIVMAFLGFCMAYWTAYIIVGQGKGPKGRFIMLTYNLTALYAYSLTTPDDEDGGDEEDTGKRPLIVQIATHRVVAVISGTIWGLIITRVIWPISARQKLKDGLSLLWLRMGLIWKRDPLATFTDGLHPNRYMNLREEFYLQKFLAKLQGLVEASKSEFEFRRPFPHETYARILRKTEEMLGAFHAMNQVILQDLNASPGEEALLSATADERAQLCVRISHLFSVLASSMKLEYSIASDALPNIEHTRDRLLARIFAYRRNDAQEQRSTDEDYSLFFTYALVTGQLNLGIQDVLKDLGELFGVMDEEALRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y6T4</accession>
    <name>A0A0D1Y6T4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230792.1">
        <property type="nucleotide sequence ID" value="XM_016385848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y6T4"/>
    <dbReference type="STRING" id="91928.A0A0D1Y6T4"/>
    <dbReference type="GeneID" id="27338623"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11540"/>
    <dbReference type="HOGENOM" id="CLU_025462_0_2_1"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="52934" checksum="EA0B9B077ADC8884" modified="2015-04-29" version="1">MDSETLKQSLRDLVARSQPYIKQASGHILASRDHCESFLKSAHPELRRFLEESRGREILPAVLLLIFLTLGLSSYIRSRRKPNSIRPSTPTIEKASSTFAKPTRKPGTWEPSSFKFPTPPPYPDWSITETKPLPYRPFRHGPKYFVTMGLRNVKHQEWIELDNHYPRYHDDKARRIIERGPKCCRTAPEALPAALELLEELSSYLPARYPTLYKRTETGILNLWSNEHVDTTSRPLPEDPMQSCARLVQDDLAIMIERPDGQYYLLAGAILLAGFWRLEDKLGMPLSEIHTSGDVPQYREKLEKGMMNFFRRLKPEELVARNNYFLQVDEDLAWSHSIGSEDSDGISWNTAEKNRAIEHHYFRSERQTLRRLPKSGGVVFTIRTYFHPITEIAEEDYVPGRLASAVRSWGSDVSRYKGKEKYEEVLLEYLDKKHQEQLDRGLKVEEEDDRRSYPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7F6</accession>
    <name>A0A0D1Y7F6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231057.1">
        <property type="nucleotide sequence ID" value="XM_016384455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7F6"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7F6"/>
    <dbReference type="GeneID" id="27337223"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10140"/>
    <dbReference type="HOGENOM" id="CLU_090028_0_0_1"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000066">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="65"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW10841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="174" mass="19589" checksum="7976902D293E02F2" modified="2015-04-29" version="1">MSDTGLPPDWEVRHSNSKNLPYYFNQKTHESRWEPPEDADTEKLKIYMAQHHSSANTRIDGAPADGKIRVAHLLVKHRDSRRPSSWRETNITRSKEEAIEMLKGYEEEIRSGQKSLGDLAVSESDCSSARKRGDLGFFGKGQMQKEFEDASFALAPGEMSGVVETASGVHLIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7S8</accession>
    <name>A0A0D1Y7S8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231187.1">
        <property type="nucleotide sequence ID" value="XM_016384585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7S8"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7S8"/>
    <dbReference type="GeneID" id="27337353"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10270"/>
    <dbReference type="HOGENOM" id="CLU_022730_2_1_1"/>
    <dbReference type="OrthoDB" id="512662at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="484" mass="52787" checksum="A0AF2CF0B378CA38" modified="2015-04-29" version="1">MGSSIDPSIWQTLAARLVRDPGTPVDNPTTSFWQEPLLPIAQHASSSLPKDAEVVIIGSGIAGISTALHLLRRDPRLSIVMLEARTAISGATGRNGGHIKAVPWADYFALKETYGKESAMKITKFRLAHLEAMVAEAEALGEEGKVGLVRRVDGVCAIYDKDFWTQAKLRLGVFLDDFPEEKGRWNIHEDEKELKALELADAHGCIVGPAGAAWPYRFLGVVLSRLLQSGQLSLETHTVAKDIRRTSSPTHPYEVHTTRGTVVTKHVIHCTNGHAAHLLPALKGKLYPLRGQMTVQAVPPGFPRAGMQRSYSPMWAKGFDYITQSAGEDGSLYLGGGLLQDGLDNDEDLGNPDDSRLSAGCLRHLEAVPGRAFVHGKGSTIEKKWTGIMGFTGDGLPLVDRVHQYLSGREECDPAAGGEWLAAGWDGYGMVHCWLTGKALAAMVTDHEDEVLEWFPRAEFACTQDRLARMSPESALRHLLGHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YA44</accession>
    <name>A0A0D1YA44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_09094</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232037.1">
        <property type="nucleotide sequence ID" value="XM_016383414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YA44"/>
    <dbReference type="STRING" id="91928.A0A0D1YA44"/>
    <dbReference type="GeneID" id="27336177"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09094"/>
    <dbReference type="HOGENOM" id="CLU_011500_3_1_1"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="243"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW11821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="679" mass="75944" checksum="2CEAFD305A18E092" modified="2015-04-29" version="1">MSQTTPHPLDPLTPEEISQTANHVRRAFPGKDAYFRVITLSEPPKADMIKYLEAEHGDYLQTITLPRLAMVQTFLGPRDSSHYYQLKVDVETGGIVEQKQLVGCHGHVDATDMQRAERECLNDARVQAAIRDMKLPAGAEVKIEPWTYATDGMNDMSEKITMCYFYMKLIDHPDANHYAYPLDLCVEMSGDARVLQIFYLPPGTSNDISTSAQAYDEKKIHGSEIEYHPDLRTTQRTTTKPYRVSQPDGPSFQVQGNLLQWEKWRFRVGFNYREGLTLHDVRYDGRSVFYRLSLAEMFVPYGDPRMPYTRKAAFDLGNDGAGCTANNLQLGCDCLGHIKYFDGWHSTSAGDPLKLPNAVCCHEIDDGILWKHTNFRTGNAVVTRSRVLVLQTIITVSNYEYIFAFQFGQDASLHYEVRATGIVSTVPIGVGEKVPFGTAVAPGVLAPYHQHLFSLRIDPAVAGYQNSLVIEESHAMPIQDPQVHNPFGVGYTTESRVVENECGLDLDHSVNRVFKIVNEQVINPVTGGPVGYKLAPCYSQLLLAHPSSYHAKRSEYGAHAVWVTRHSDDELFPSGHHTMQSLGGQGIASWIKDRQEKKQPTSVKNSDIVVWHTFGSTHNPRVEDWPVMPTEKMIVGMKPVNFFTSNPAIDVPVSTQETNQSVLVEGVAAMPTKGHCSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YB45</accession>
    <name>A0A0D1YB45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA damage-inducible protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_09411</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds ubiquitin and polyubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232352.1">
        <property type="nucleotide sequence ID" value="XM_016383729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YB45"/>
    <dbReference type="STRING" id="91928.A0A0D1YB45"/>
    <dbReference type="MEROPS" id="A28.A06"/>
    <dbReference type="GeneID" id="27336494"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09411"/>
    <dbReference type="HOGENOM" id="CLU_020435_2_0_1"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="14">
        <location>
            <begin position="192"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="12">
        <location>
            <begin position="370"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW12136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="408" mass="44703" checksum="D50B6BBC2BAFD0EE" modified="2015-04-29" version="1">MSLNDIKAFVEAEINIPPTAQHFLHEGRPVTDTSITLAQMNVREGDVVALAVQTRQRRRTANENTTGQPAQRVRSGNDPEQLRLRILGDSHLLAECQRQDPELAAACSDRQKFHDLWSLRQRQNEEAQRQKEEQIALLQADPFNVEAQQKIEEMIRQERVAENLQKAMEENPESFGRVTMLYIDVTVNNVPIKAFVDSGAQTTIMSPSAAERCGILRLIDKRYGGIARGVGTATILGRVHSADIQIGQYNLASSFTVMEGKDVDLLLGLDMLKRHQMCIDLKKNCLRVQEDEIPFLPESDIPKMMEEILENEPKVAGPDGSTIGATTGTVEPHTESSTSSEPTAGPSGTSAQPSSSQSGAATGNFGQSQPITPESIAKVTELGFTREEAIAALRQVDGNVELAIGLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDC7</accession>
    <name>A0A0D1YDC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233177.1">
        <property type="nucleotide sequence ID" value="XM_016382474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDC7"/>
    <dbReference type="STRING" id="91928.A0A0D1YDC7"/>
    <dbReference type="GeneID" id="27335231"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08148"/>
    <dbReference type="HOGENOM" id="CLU_010595_7_1_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF102">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37710" checksum="F54F0EF61209211C" modified="2015-04-29" version="1">MSSPGQISDHANFEIEADELNEADSTLGDDISQATESIRSSLHQGVVENGRQYHKYKDGSYILPEDDMEQERLDLQHEMFLKSFGRKLYLAPIDCELHEVLDLGTGTGMWAIQFADEHPRSSVLGIDLSPMQPTSVPPNCKFEVDDFDTPWAFQKQFDFIHGRMLLTASADFPALFRRAYDSLKPGGWFEMQDLYMPLLSDDGTLEGTAFGEWNEKYMEACAVLKRDPSWTAKYKEWITGAGFTNVKEQIFKWPINPWPKDKYLKEMGLWNMVNMLDGLDGFTVRLWTVALGMAVEDIQAFLVSVRKDIRDTKIHSYWPIHVVYGQKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YF01</accession>
    <name>A0A0D1YF01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233857.1">
        <property type="nucleotide sequence ID" value="XM_016383154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YF01"/>
    <dbReference type="STRING" id="91928.A0A0D1YF01"/>
    <dbReference type="GeneID" id="27335915"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08832"/>
    <dbReference type="HOGENOM" id="CLU_030571_1_1_1"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="52"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW13641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="328" mass="36999" checksum="8120780CC9C80C3B" modified="2015-04-29" version="1">MSSAYLKRAPPSPPESASETTVEVYALKAGHLTLPERFFVDPASETERKTVPSLSFLVVHQDAETNQKTRIVFDLGIRRDPKRYIEPIQRHIETRQPLDTLPDVTASLAVGGLSPEDIDYVIYSHVHWDHVGEPRDFPRSTFVIGNGAQALLQGGGSLRGSHSFFESDLLPEGRTIELSNPYEDAEEQTKKRQEPTSGPDFDQEWKPYGNLPRVLDLFHDGSLYIVDAPGHLPGHINLLARTGPMSSIYLAGDACHDRRIMRKERAIGEWLDDHGQICCIHADRKLAEQTIERIQELESKGVECVFAHDFEWEENPQNQSRFFGPHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YF80</accession>
    <name>A0A0D1YF80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233967.1">
        <property type="nucleotide sequence ID" value="XM_016383264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YF80"/>
    <dbReference type="STRING" id="91928.A0A0D1YF80"/>
    <dbReference type="GeneID" id="27336025"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08942"/>
    <dbReference type="HOGENOM" id="CLU_046006_7_0_1"/>
    <dbReference type="OrthoDB" id="4118563at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF6">
        <property type="entry name" value="BLR8189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="12"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="176" mass="19190" checksum="B13249FD6C3B2F83" modified="2015-04-29" version="1">MANSGVTGTTCAINHVALSVDDLDQAVQWYTENLGFCEIIPSAYMDREKDPKGIVFRVYGGELHKVKVAYLEASNSVGFEIFQFIDPKSEAGTVQQPTRFDARSWTQGGFFHVAVTAAEPQKLASKIEDAGGRRVGDAVTLSNGHTALYVQDPWGNAIEICSTNFFDLITSANRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YFF6</accession>
    <name>A0A0D1YFF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_06596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234032.1">
        <property type="nucleotide sequence ID" value="XM_016380930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YFF6"/>
    <dbReference type="GeneID" id="27333679"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06596"/>
    <dbReference type="HOGENOM" id="CLU_1209847_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="229" mass="24783" checksum="6CFF281CE33C77F1" modified="2015-04-29" version="1">MSDEIDAGRCNELAQIDPASPCCWCPRKPSPNYCRYRAVSLVAFCYASWMTQEHRTGPTAEVERRANGRHAEGPSVTVRVCGHIGPGQSVEAGDATGAAVAAVAASMDNNPSALEPTVVQNGRVGGVVDDMQPRQEAIFTQPEFAMGQDDPRKITRTKSTQPRCSTQKRTWWPFVNVDFEAAGFILESAFLAIPAMLFCVTIPSTYLDVGALKLIRLSNKGVTSGFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YFI1</accession>
    <name>A0A0D1YFI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234047.1">
        <property type="nucleotide sequence ID" value="XM_016380945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YFI1"/>
    <dbReference type="STRING" id="91928.A0A0D1YFI1"/>
    <dbReference type="GeneID" id="27333694"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06611"/>
    <dbReference type="HOGENOM" id="CLU_082177_3_1_1"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.10:FF:000013">
        <property type="entry name" value="37S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="166" mass="18742" checksum="E28929FD944F01C6" modified="2015-04-29" version="1">MSLRLSSSLGLQLRVASSQPLRAAITQVPVRNAARLAVRSKDEQKAQENQALSRQMTRTWKVGDVYAPHDLSGAEARKWKQRTRPTTDVFDALSVNPLSLYKNFSIMSEYMTEMGRIRHSSSTGLRPVNQRKIAKAIRRAISLGLMPSVHRHPEILKAQLQKRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YGA1</accession>
    <name>A0A0D1YGA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234222.1">
        <property type="nucleotide sequence ID" value="XM_016381120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YGA1"/>
    <dbReference type="GeneID" id="27333870"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06787"/>
    <dbReference type="HOGENOM" id="CLU_135725_0_0_1"/>
    <dbReference type="OrthoDB" id="5386823at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="118" mass="11967" checksum="9C80B05ED6EE076A" modified="2015-04-29" version="1">MSSSDTGDKTMDTVPGGETPQYESIKTQTLPTPKQRGQLGSGPNTSEEASISEERAQKTADNIRYGQNISESGVGGKTTSSIGSAGQEGGFGGTPDQSGKQPDSRPQQGYGPGSGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YI32</accession>
    <name>A0A0D1YI32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234797.1">
        <property type="nucleotide sequence ID" value="XM_016381695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YI32"/>
    <dbReference type="STRING" id="91928.A0A0D1YI32"/>
    <dbReference type="GeneID" id="27334448"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07365"/>
    <dbReference type="HOGENOM" id="CLU_007060_0_0_1"/>
    <dbReference type="OrthoDB" id="3231004at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="818" mass="89906" checksum="5979D24E80018C6A" modified="2015-04-29" version="1">MDDCGPLYNVRMKRGQGYNSYIQEVRIDNAVTITKLQDNARTASLTGSDSETVTASLTTTASVSNAPPKQGIDMTDLIAVVKEGLKTTTAESPQQPKLPYLLKLDPNARHNQTVTFSSKQVKSVLEMNNAMGFNASAAIKATSLGPGAEAGSSLATSNDLGANDVNFLVHVKVVNEADDRKEEWSFNEVTGLNEVLSDDKDTHTRSVEFTRIYGDCFISDFVEGGEMYAWIGIKSLDRKNSRQLALHASAQLTPMALPVQASGKMDMSQERSRLFSQATTSIRIQWRGGGQIKNHDFPWGMDNLVLIANAFPSMVAAKPAKIRAVLTSYAALKSFQDHRLANPRIPLPLTYDHCAIYTSTLYEDFVAFQELCETLNDMIRVPQNYRNRDDDKTKKDSQKMALQASVAAQVPGGGVEAGFEFSRSGPRYSVVAQTAVPAGDDTETDRKTRPLMDLDAILLDTTRRLASMDPDPQKLSMMRLLCRSSMIYIQEQAAALVVDPERSITKHDEHGRHVYSLPKYVCPGVIQSILPVPKYDDNSSSSDWRVKDLADLSAAKNILSSPSNYWWDVIGEPLSQYKKYKHFAIGNFDLEDEEFPQRIAVQPFEAAWYRGRRVKDSHNAIGGIGLGYADNKSVLNVNVKTVEGNEIRGLKNSTTEEQGTMFANMYVGCKPGPERWKQIDERGLAAAPINRVHVYYLPGTGRIAGLEFLSDPSLTDGNDALARATPVFVHKAWEQGTNADSVEAEKLLDRMECQALYPGDGLSGDEIDKNWMFAGLVGAFEKVGVLGSVGSSTGGRVLAKVAVIWKRRPGSLNTVANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIS6</accession>
    <name>A0A0D1YIS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235057.1">
        <property type="nucleotide sequence ID" value="XM_016381955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIS6"/>
    <dbReference type="STRING" id="91928.A0A0D1YIS6"/>
    <dbReference type="GeneID" id="27334709"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07626"/>
    <dbReference type="HOGENOM" id="CLU_069674_0_0_1"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="278" mass="29840" checksum="30F68CE75252C578" modified="2015-04-29" version="1">MPMTLTVGVLALQGAFLEHLILLKRAASHLHSQGLTASFDFTEVRNVEQLSRCDALIIPGGESTTISLVAAESGLLEPLRDFVKVDRKPTWGTCAGLILLSEAANATKKGGQELIGGLDVRVNRNHFGRQVESFQADLNLPFLKSEEPVSNEPFPGIFIRAPVVEKILPNVEGVQKGEQQVAQTVVAPSKSARDKQARQAMSSHVDVMGVLPGRLKKATAVGAEVNAGEEVGDIIAVKQGNVFGTSFHPELTADIRIHVWWLKQVMDAVGRSPVTGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YM25</accession>
    <name>A0A0D1YM25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase IS30-like HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236257.1">
        <property type="nucleotide sequence ID" value="XM_016380430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YM25"/>
    <dbReference type="STRING" id="91928.A0A0D1YM25"/>
    <dbReference type="GeneID" id="27333175"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06092"/>
    <dbReference type="HOGENOM" id="CLU_2606045_0_0_1"/>
    <dbReference type="OrthoDB" id="2117591at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="9279" checksum="71DAD387EFA22541" modified="2015-04-29" version="1">MADSSPSTPPRRRRLTRDQRRDILLMRRLGYTYQYIAEFLKISQRAVQYTCQSGQASPQHRNAGRRPRPSKEGTDSRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNR7</accession>
    <name>A0A0D1YNR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_03946</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236972.1">
        <property type="nucleotide sequence ID" value="XM_016378295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNR7"/>
    <dbReference type="STRING" id="91928.A0A0D1YNR7"/>
    <dbReference type="GeneID" id="27331029"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03946"/>
    <dbReference type="HOGENOM" id="CLU_009617_1_0_1"/>
    <dbReference type="OrthoDB" id="2283631at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF79">
        <property type="entry name" value="C6 FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="662"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="793"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="804"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="818"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="843"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW16756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="930" mass="103089" checksum="0E5DDE77BCF793DC" modified="2015-04-29" version="1">MQNFSITSGPPSGPKNYVFVDEHNRHKRLKVMRACEGCRRRKIKCDSATTNTWPCAACVRLKLHCVPPAGGLEGETGDSGPDSAVEQSIESQPFVQNPTPSLQQAPSYGLATPPFPATQAGNFAYDAYVANYSKPPYDITENGYYPNPQQYPGALDDQYQAGAHAFPQYQGDPDSQREERAASTPMDQMTAEELMEYLGQLKIGENGIAPYLRPEKTQGKDSVAPVNEPEAEAKIAAAFSTDAGSHIRIPPALMPSDEEASQAFQTFFRDVHPYVPVLNRRQFYDQWRNDRASISPLILEAIFANAGRLSDDPAQGAQWLALANKHEACFLDSPRLSTIQALLLLLKARESAPKRGYYYRSWMTCKTAVTMAKDLELDEHYEVHTSGESCGSTKIECLTKTRLWQTLLVCETMVGGPQGRTDLGVDPKSVDTSVNPPSSDVDDFEKAISRQFAYFVRNARNIRLITDVSIKLKKKKDWGLDQEFVAHNVAFKKWPDELPKDLQVTFPQDGGVPTLPSHFVGNMHSHYHLAIVMLHRPQLKASESFGADTQWRHHMSTCYQSAKALCRLQEAVLAQYDLTGLLYMQRGINFTIYAILTCVMIHLIALSSPDPEYNLEAKDYFVRHMRILERCIAAWPMPETEAQINSLRSAFSADVNKPFELKESFPLGSPSDQSRPSPASQGPYEKQQQQQQQQSTPQVSVKTEIQQPQPNYFPSHIQQMRGPAGYLATPPVSAYSSDSQPQTPLYAQQYDVDQAHYTSMPTSAYYHQQGTSAPELQWNPTPIIDQFDTAFAIPPSQLAPPPSSLYGGSSSSPPGGSMQNMQASFTSTGSPTYGGINSQNYPQQQQQQQQQQQQHYFASQPQSFPDLSSPVAGHMGQLPAASSSSSTAYPASGVGAGMFVTSRQWQQSVANVMDTGGLKRRGDFDQQRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YP29</accession>
    <name>A0A0D1YP29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237127.1">
        <property type="nucleotide sequence ID" value="XM_016378450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YP29"/>
    <dbReference type="STRING" id="91928.A0A0D1YP29"/>
    <dbReference type="GeneID" id="27331184"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04101"/>
    <dbReference type="HOGENOM" id="CLU_009665_3_1_1"/>
    <dbReference type="OrthoDB" id="4111246at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="316"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="464" mass="52167" checksum="351B1C168883B3A7" modified="2015-04-29" version="1">MGDQFKVIIIGSGLSGTLLANGLIRNNVEVTVYERLTKGIKREGYQIRIGPDSLRGFQACLDDGQVREVLGKCGRSNGSRSSAPVMYDKNFNVLLDATKFPTYNKSAPINRVILRDILAKPVEDAGCVLSGKQFERYSILNPGTTSERVRAHFSDGSWDDCDLLIGADGSHSKINRQVGLNNISELGTHLFMISKCELPTERYRTMSSPLQNYPLLTFADNMSMFYCAYLPDKENEETLNEGARSFDDKLSSCMFALIVPVDKCPPDFSQLPVEEQWDFIAATLRSWAPEYHEIVDLLRGSSIYAYKTRASKRPSMSWRKKVQRSGAVEQGHPRVWLLGDAMHAMLPARGMGGNTAMRDTETMLPLVTELAEYAEEHKSLPSTVIAEKLAQYEAEMIPRAFEWVEKSGGTTIMPLDSTRFLSRVFFFVAAQAMNLSYLWKKFTSIFTKAKPVQTDVDFERYLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQK3</accession>
    <name>A0A0D1YQK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237712.1">
        <property type="nucleotide sequence ID" value="XM_016379035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YQK3"/>
    <dbReference type="GeneID" id="27331773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04690"/>
    <dbReference type="HOGENOM" id="CLU_1540072_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="174" mass="19523" checksum="F463493A0132AC4C" modified="2015-04-29" version="1">MASTQKTLMTPPPKQHKLLPMAAASTTTPAPKLARKTRPPPSLFVKDKKKPANAQIGIFDKPNQSDLERGFIEGGPVTSIERPYLVLLECRRGFTKKDMVLGLKTRPKATIIPIAKDAKTISQEGRMKELLAITKAEKEQREGGKKRRREEEEDVKKEAGKQQGRPKKLFKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YTL2</accession>
    <name>A0A0D1YTL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_02849</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238777.1">
        <property type="nucleotide sequence ID" value="XM_016377207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YTL2"/>
    <dbReference type="STRING" id="91928.A0A0D1YTL2"/>
    <dbReference type="GeneID" id="27329932"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02849"/>
    <dbReference type="HOGENOM" id="CLU_026337_2_0_1"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="267"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="547"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW18561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="596" mass="64534" checksum="A85E22B0BC9B756D" modified="2015-04-29" version="1">MSTLADELLNDFEDSGDENEDQTLQDHETADGLNGTHHDDSEEGLAEDVANDGAMEEDEEEKEFVSADVLEDEDETKAKVEKMHLGMVRDVRSVAGLMKILQPVLDKISHYQNLPPNLRTSTVGSIEDNPEYHLLTQSNSLSTQIDNEIILVHKFIRDHYSTRFPELETLVQNPLDYAKTVAIIRNGPLENIKALADSTDNLVKATLRSVLDGPTLMVVTVEGTTTKGQPLSDAELETTLRACQMVIELDRAKKILTEYVQSRMNIFAPNLTAIIGSLTAAQLLNFAGGIKGLAKVPDRNIPAMGSRKQKQSGLATNVGIRQQGFLYHSPLIQSIPNDLKIQAMRIVSAKLVLAARVDSVHQAPDGSTGEQLRDDCLRRLDKLTEPPPNRGPRALPAPDDKPSRKRGGRRARKAKEATAMTELRKQQNRMAFGKEEKEVGYGTGEETVGLGMIGQSNDGRIRATQIDRRTMAKLSKKNPGWGGSGTATSLNSGMNTSLKGFGMGGNTTSLRASGLRTSGVGGTASSIAFTPVQGLELVDPKVQAELKRKRDAESAGYFSSGTFTQANAGKSEGGFKVPSLPPSKKSNMGPPPTPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUB2</accession>
    <name>A0A0D1YUB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239062.1">
        <property type="nucleotide sequence ID" value="XM_016377492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUB2"/>
    <dbReference type="STRING" id="91928.A0A0D1YUB2"/>
    <dbReference type="GeneID" id="27330218"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03135"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="94"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="243"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="556" mass="61430" checksum="AEF2E5D351FBD41B" modified="2015-04-29" version="1">MASRSLPIVVVKPMPKGTPEYEANRLPILAALSKNIPEEWYLPQELIDNPPRDVSNIPRTCGLLNAEELEITENYDATGLAEAIAARKYTSVAVVKAFVKRASIAHQLVCCLTQLFPDDAVEQAAKLDEYLAKTGQTVGPLHGVPISIKDHMPIAGHKSSYGELATTYDDDKDCLFVKILRKAGAVFYCKTNQPQALMHMESSSHFGRTLNPYNIQLTCGGSSGGEGALLGMKASVLGIGSDIGGSIRAPAAFNGVYGWKPSSNMLPFQGMIRGAFPAELNVLPVAGPLGRSLRDMNLVTKAVLDAEPYREDPKLFPTPWKGLQAPFSRKLKVGIIENDGFIEPQPPVKRAIAWVRKLLSDPKYKDLVEVKDFQQYKAAEAFDKAFRMFLPDGGAGVLAILEASGEPVLPLTRWFIPEGSEMKNASEVAVLRQERDEFRTEYAAHWNSQNVDVVIGPCYVGPAAEHDTARFWTYTSFWNLVDYPGLVFPTPIKVEAGEIYAEDYEPLSDQCRIIKQEWEAGEFERAPITLQVNARKYHDDQLFSAMAILKDILNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXR9</accession>
    <name>A0A0D1YXR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor cwc26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240277.1">
        <property type="nucleotide sequence ID" value="XM_016375001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXR9"/>
    <dbReference type="STRING" id="91928.A0A0D1YXR9"/>
    <dbReference type="GeneID" id="27327719"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00636"/>
    <dbReference type="HOGENOM" id="CLU_024195_0_0_1"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43961" checksum="88C33092491CC9A7" modified="2015-04-29" version="1">MPSSNLAAYLAKNYLTASNSSNQNGSGDFQDSNRPKKKRRKNKDASADSGLIIADDDEPLTLKSSSARPRDDDDGDMPIYDTNVRSAEFRKKKGGGGWKVIAQPDTNTTATAQAEVDEADRIIAAAAEEADARRREIEDEDAPAIVDTQDGGVDDTNSTPRMSSGVKAGLQTADDTARLVEHEERERERELALEQRKKKSSSRKKGGDGRGDGETDAAEETIYRDATGRRIDISMKRAEARAAEEEKRRAERQAREDAMGEVQRREKEARKQDLQEAKFLSLARGVEDEDMNEDLKRAVRWDDPMAAYMAQKQAEEHDATDPGAVTTTAAAAAGKTGKSRNKKVYVGAAPPNRYGIPPGWRWDGVDRSNGFEKEWFLARSRKGRNADLEYQWQMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZD9</accession>
    <name>A0A0D1YZD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_01248</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240887.1">
        <property type="nucleotide sequence ID" value="XM_016375611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZD9"/>
    <dbReference type="STRING" id="91928.A0A0D1YZD9"/>
    <dbReference type="GeneID" id="27328331"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01248"/>
    <dbReference type="HOGENOM" id="CLU_004298_1_0_1"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="747"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="816"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="853"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="906"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="941"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="984"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW20671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1019" mass="112216" checksum="38924F4E4A23F1BF" modified="2015-04-29" version="1">MSTLADQSPQAESFNGATSTVTPDTEARERQRSIAFKVSHVLISVFFLWLTIVHIIGILFFAKGFLLTRLVLDNKSECTALPSGQQSREANGCWHPKSFNRAVVIIIDALRYDFTVPSTASPSIKHPQRHYLDNLPTLYDTAVANPEHAFLLPFIADPPTSTLQRLKGLTTGTLPVFIDIGSNFAGTAIDEDNIVSQLKDAGKTIVHLGDDTWQSLFPGYFDPNMTRPYDSFNVWDLHTVDNGVIEHIMPLLEQSPARWDVVFGHFLGVDHAGHRYGPEHPAMAEKLRQMDGVIQQIMQRLDDDTLLVIMGDHGMDAKGDHGGESDDEVEAALWMYSKKPRFGRVSPDSLTPPLNAKERPIGQIDLVSTLSLLLGLPVPFNNLGRPIAEAFAGPGKTKWQNLAEVAHLVQAQIARYQRHYSQSRDLGLSDDVYQSQAAHMMRSVDAIGTGRWQDSYHAFVDWHEEVISTYRKLWANFNLGDMLYGVCISAAALAFLLFFARFSKGDKALVATGLLRSAGLGSTAGLALGPVLGIILPKYFTAIAGLVFGVTCGGILGASVWSYQNNVARRFRFPSIWGWMTFVFVVTQAAGFASNSYTIHEDTILLFFLTTFGLVALISSLRQAYQKDRILGVYQSVMFVLLARLSSFSRLCREEQMPGCRSTFYASTTSSTSAPWQLLVPFAVALILPEITKAFYRGTASYAGSAGFWIGFCFRIGLLLVAVYWTLDAADNGEWWRHRISSSTLQTAKITVARCVLAIALPVGVSTFIWAKPCIDISITDPKSSARGTQAPSRPQLTVFGYANAFGSRFYLMIPMLVLTVALLLPPMGQFSIAICAWQILCLLEILDSNALAMTWASPSSVGPIVLALLGSYHFFKTGHQATLASIQWSSAFVPLRTIRYPWSPLLVILNTFGAQIMCAAAVPLTVLWKRPLGKAGLRGVWHDVVNACLTHALYYATIQLATTMWAGHLRRHLMLYRVFMPRYLMASGVLLIVDVVLVVAALGGARVVGLSVGEVFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZF1</accession>
    <name>A0A0D1YZF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240902.1">
        <property type="nucleotide sequence ID" value="XM_016375626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZF1"/>
    <dbReference type="STRING" id="91928.A0A0D1YZF1"/>
    <dbReference type="GeneID" id="27328346"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01263"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_1_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF236">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="448" mass="49923" checksum="01BE539158A984E6" modified="2015-04-29" version="1">MSNFARLPPSGVKVIIVGAGFAGLCAAIECDRKGHSVILLEKVKELKPLGDVISFSSNSGHIFERWEGVVDELDPITHKSKGLDFHDWMGNFATRQVWDVEKQWGRRINGHRGQIHDVVYRHAKARGIDIRLGQHVTDYFETDTEAGVVSNGEKLVADCVLAAEGVKSAGRKIVLGFEDPPKPSGYAVYRSWFKSDELAKNPRTKHLVINGDTHTGWIGEDKHFLAASVKNGTEFSWVLTHKDDADIDEDWQFPGDKAEVKKNLEGWAPIVHDIVDATPPDRLFDYKLVFRDPLPTFLSPKARIALIGDAAHPFLPTSIQGASQSMEDGVTLAVTLEKAGKDNVQLGLRAYEAIRYGRVHRAQMTGVTTREQWHKADWDKIWKDPKSLHLKREPWLLDFDAEPHAYEVVDGVLNDLRRGKDVKANGLSEPANKNGLATVVAQEVDQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZF7</accession>
    <name>A0A0D1YZF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_01273</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240912.1">
        <property type="nucleotide sequence ID" value="XM_016375636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZF7"/>
    <dbReference type="STRING" id="91928.A0A0D1YZF7"/>
    <dbReference type="GeneID" id="27328356"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01273"/>
    <dbReference type="HOGENOM" id="CLU_018204_1_2_1"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="150"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="264"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW20696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="51135" checksum="3DA1E9D58C8FE433" modified="2015-04-29" version="1">MAPAPTASESIPPIAQPFVSERARKLLDVVEKFVDEECIPADAVYHAQIGLGEARWQGHPSVMDDLKRKAQSLGLWNMFLPKNHFKEGPQFTNVEYGLMAEQLGKSITASEACNCAAPDTGNMEVIARYGSPAQKERWLKPLMAGEIRSAFLMTEPDIASSDGSNIRLRMERKGDHYVLNGSKWWSSGAGDDRCKIFITMGQTAPDHPDRYQRQSMMLVPADTPGITVHRMLSVYGFDDAPHGHGHITFTNVRVPLDAMILGEGRGNEIMQGRLGPGRIHHAMRGIGASEKALEWLINRLNDERKVPFGKPLAEHGVLLEWVAKARIEIDACRLIVLNAAIKTDQRDAKFALREIAEAKVKVPQVALEVIDRAVQAYGAAGVCQDTPLAYMWAHLRTLRIADGPDEVHLQQLGKRENRTRRDAIKAKLARQAQRSDELFRTMGVEKVALGAQKFQTKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0G5</accession>
    <name>A0A0D1Z0G5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241297.1">
        <property type="nucleotide sequence ID" value="XM_016376021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0G5"/>
    <dbReference type="GeneID" id="27328743"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01660"/>
    <dbReference type="HOGENOM" id="CLU_1026850_0_0_1"/>
    <dbReference type="OrthoDB" id="4155053at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="244" mass="27074" checksum="309CF64B592A3F00" modified="2015-04-29" version="1">MADTASKEVWQEFFVQHDSLVSLLDSHAAVLVELRHRYAGSSEAVEALTTRLLSTETLLAGFKSSTEALRSITDQDDFESTDAASGRHAPLPTATPMVDSSGLFSFDANPSIVSDLLKGNTTPKRKLQADGDTDLEHERKKPKPNGQFQQESSEEEDSFVRGVEARVQAKANRKKDRTEKKRKRQSDGSTSGGKKSHQNKRQKQEGKPSGNKPLETRQNNNGKRPQASSKSSMRGNKTHKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZE15</accession>
    <name>A0A0D1ZE15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231473.1">
        <property type="nucleotide sequence ID" value="XM_016384871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZE15"/>
    <dbReference type="STRING" id="91928.A0A0D1ZE15"/>
    <dbReference type="GeneID" id="27337640"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10557"/>
    <dbReference type="HOGENOM" id="CLU_035756_2_0_1"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF10">
        <property type="entry name" value="INOSITOLPHOSPHOTRANSFERASE AUR1_IPT1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="191"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="422" mass="47833" checksum="352DA3EC9227F4A0" modified="2015-04-29" version="1">MAAAVVNVTEAAVAAQPNMGGAQFASHAWVEPIIVVSIMITSLTVNRKRNYRILDSNRGRSPTRSLLPHESQEYSPDSLGELDSYESSESDVLTSSKYPPKKRDCCGMVIRTPNSSRFSDHVHSRILQKFPFLIEMFYWVLNLLFYVLTKAIAQLTMSGDDGLRDLAQDHGILILDIEHKSWLSFLFPIREAAFQGWFLNGHLTAITFLNRIYSLVHIPGTVAFLSWYYYSAPNHATFATVRRTMTLGNFAAFAIFTVFPTMPPRLLPQEFGFHDTVRQDNAESVWVGGNYVNQLAAMPSLHFTYAFVIGCTFLYHSGLFRRAQRNEPRKSTFMQIFYLVAGICYPLLVLTVIVATANHYWLDAVVAMMTTTLSLLCNKIWMFLLPAEDVLCWILRVDKPVPTTGDRLKGEKYLPVKDEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZEZ9</accession>
    <name>A0A0D1ZEZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231733.1">
        <property type="nucleotide sequence ID" value="XM_016385131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZEZ9"/>
    <dbReference type="GeneID" id="27337901"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10818"/>
    <dbReference type="HOGENOM" id="CLU_331202_0_0_1"/>
    <dbReference type="OrthoDB" id="4117168at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="485"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="778"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="892"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="921" mass="102548" checksum="BBF1E8CECA7CC2EC" modified="2015-04-29" version="1">MAPQSTSKPPNLTLRAVPNGGLGGLIPSDKAGITGRSMAANASFVQATVLGKRRQKPPPILTSRSLSDLSITSVKASAGSVLEYVWPWTPKTPKDCTCAESLPGESRKILQLPVVVPKDAAVTSDLYQSLPETPVTLVSDLTSPPVELPGSLLLPSQGFPQTDPISPPPSLYRSRRDTQESIISLVPTQSTSVSTDDLAMETLRNLTTSSRRNDQSAIPSYTIGSRNVPESRITKPFTAMTVEELLDYLPQCKNSDTVKELWLPALRIHMDKMAALILDATEIKVDEGLDQITLNQDLNHFAHEIRLVSNSFRKIVDSAESLAERDSRISHERLELLEGQIEDCLKTMYSKQKVVDTQSRTIEELNHTIRDIVRILGTFIQKNIPHLVDFVEDPRTQEVLQVVSDYAPHGDDRPVPYLRVPETTISKYAQAAREADVALSEYRKMLHVQSATIREQSHNLDAYTSKYEGVVRLVKERDHEMGLLMQQKEDIMKDLEKTKSALIQSQLADVEKQDLAQRYEELLHEATNLKIAHRMELEQRELEICKLRQKLGSAREEVIARREDVKNIMSQTRAVLESARQPEPTLRNSNASKALRFLGMEREKDKSKSTSSLASSQSLMTFAPETANSADLKCSFKEQAPRLSKPIAQHLGSTDQGFSTQSGPKAYTASRRSPGESALTLPRPRAGSLSAMQNRATSRLPIDTQKLLPDPPVRPETHRLSSARVAEITQCISSPTAAQIASDYFKHSVLGQTSARRVLSHIPELSVQTAPEANLPHNEGHHDERRKSDDSVASADREMYRHSVCALDMLNSNTLPYNPTEDNLTEYFEHSQTRITPDPDYDEDMDNGEDACFQTGVAHLHHVGPGSNNLRAALVNRRKTREVDDQARKSIVSDTSEYQTSDSEPMTVTQLYHEGGRHIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZF16</accession>
    <name>A0A0D1ZF16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231758.1">
        <property type="nucleotide sequence ID" value="XM_016385156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZF16"/>
    <dbReference type="GeneID" id="27337926"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10843"/>
    <dbReference type="HOGENOM" id="CLU_108086_3_0_1"/>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="155" mass="16944" checksum="048043EE08FCB832" modified="2015-04-29" version="1">MATTTTTTTEDPSSTPSPFNYVLSFLLVGICWGFTTPFIRKAAVNYTPPSHPSISDPSRSWISRQLAKAFFTVVGLLRSPGYAVPLVMNLTGSIWFFLLVGQAELSLTVPITNSLAFLFTVLGEWYAEGKLISRDTWVGMILVCAGIGLCVWSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZF49</accession>
    <name>A0A0D1ZF49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231813.1">
        <property type="nucleotide sequence ID" value="XM_016385211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZF49"/>
    <dbReference type="STRING" id="91928.A0A0D1ZF49"/>
    <dbReference type="GeneID" id="27337981"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10898"/>
    <dbReference type="HOGENOM" id="CLU_070841_0_0_1"/>
    <dbReference type="OrthoDB" id="2794762at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="183" mass="19822" checksum="6E39A287486B200B" modified="2015-04-29" version="1">MAHSSSGGDFTIHNLDSSTASKDGAIRAILALSNHIFDTSSGPPTHHSSLDEWYRRLSRPDSIVVYATPPPSGSRDPEREGAPNPGDEALGFIFAHAKVDPQLPTRTLHVWLAGTTARARGKGVFAALMKTLEQHARTRGIGTLSVCTFPDTFSNMFAILQKTGWTVQAWLEDGKKVLMSKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZFC9</accession>
    <name>A0A0D1ZFC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231933.1">
        <property type="nucleotide sequence ID" value="XM_016385331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZFC9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZFC9"/>
    <dbReference type="GeneID" id="27338102"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11019"/>
    <dbReference type="HOGENOM" id="CLU_1896225_0_0_1"/>
    <dbReference type="OrthoDB" id="3250044at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="134" mass="15393" checksum="405030C741A1A899" modified="2015-04-29" version="1">MEKWFNSRLFEHNPKLSLRNCKLVLCHLDIAPRNLLWQEDGSLCLLDWASAGYCPRLFEFCAQWIIEGKDGSFNSILLNSMNPLSDIELGQKEAILCFWRNIQKYSLVPSGIKKCFEFYPSTSSADAGIPTRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZFU6</accession>
    <name>A0A0D1ZFU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
            <ecNumber evidence="19">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">PV08_09135</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EC" id="6.3.4.16" evidence="19"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232078.1">
        <property type="nucleotide sequence ID" value="XM_016383455.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1ZFU6"/>
    <dbReference type="GeneID" id="27336218"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09135"/>
    <dbReference type="HOGENOM" id="CLU_000513_2_1_1"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00058513"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
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    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
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    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
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    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KIW11862.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="2297" mass="252073" checksum="21F5247E18BE7D6F" modified="2015-04-29" version="1">MVRTTPLTGDGRPSPSGTSLPQSPTVAASVGFPQMDRTISATPRLEGERMGSLIPIATARASQEDEAKIYLELQDGQVFEGLSFGAPKSISGELVFQTGMVGYPESVTDPSYRGQILVITFPLVGNYGVPSRETVDELLGNLPKHFESDLIHIGGLVVASYAGEAYSHHLATSSLGTWLKEQGVPAMYGVDTRALTKIIREEGSMLGRMLYASTASQAKLSNGIRPDAQSNGEVMMGPVSWREQVEPVEWHDQNKRNLVAEVSVKEPRVISPPKSKALLHPSGRPVRVLVVDVGLKYNQLRCLLARGVEVLVVPWDYNFPELAGKDYDGLFISNGPGDPAMMSTTVKHIAAAMSEGRTPIFGICLGHQLLARAAGANTLKMKFGNRGHNIPCTNLLSGRCYITSQNHGFAVDSMTLPDGWEELFVNANDGSNEGIRHVSRPYFSVQFHPESTPGPRDTEFLFDVFIDAIMKSVASVEALVQPVSFPGGTIEENDKAHPRVQVKKVLVLGSGGLSIGQAGEFDYSGSQAIKALKQEGIYTVLINPNIATIQTSKGLADKVYFLPVNADFVRKVIKHERPDGIYCTFGGQTALQVGIQLKDEFEGLGVRVLGTPIDTIITTEDRELFARSMESIGEKCAKSASASSIEEAMHVVKDIGFPVIVRAAYALGGLGSGFADNAEQLRELCTKAFAASPQVLIERSMKGWKEIEYEVVRDARDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPFSKEYCIIEVNARLSRSSALASKATGYPLAFIAAKLGLNIPLNEISNSVTKKTCACFEPSLDYVVVKIPRWDLKKFTRVSTQLGSSMKSVGEVMAIGRTFEEAIQKAIRSVDLHNLGFSDISNPLMSVDDELQTPSDQRMFAIANAMHAGYSVDKIWEMTKIDKWFLSRLKGLSDFAKLMSKYSTSTIPPSLFRQAKQLGFSDRQLARYWNSNELAVRLLRAEAGIHPVVKQIDTVAAEFPAYTNYLYLTYNGMASDVTFEDHGIMVLGSGVYRIGSSVEFDWCSVRAIRTLRQEGYKTIMCNDNPETVSTDYDEADKLYFENINLETVLDIHQLESANGVIISMGGQAPNNIALQLSRLNIKILGTSPDMIDSAENRYKFSRMLDRINVDQPAWKELTSIEEALEFCAKVKYPVLVRPSYVLSGAAMNTVYSKDDLASYLNQAVDVSREHPVVITKYIENAKEIEMDAVAKDGVMIGHFISEHVENAGVHSGDATLICPPQDLEPETIARIEEATRKIGNALNVTGPFNIQFIAKDNEIKVIECNVRASRSFPFVSKVMGVDLIEMATKVMMGRPVTPYPPVDIPADYVGVKAPQFSFSRLSGADPVLGVEMASTGEVASFGRDRYEAYLKATISTGFKLPEKNILLSIGSFKDKMEMLPSVRKLHDMGYNLFATSGTADFLEEHGIKVKYLEVLGSDEKEQKSEYSLTQHLANNKIDLYINLPSSNRFRRPANYMSKGYRTRRMAVDYQTPLITNVKIAKILIEALARHYDLSIHTIDFQTSHRTAVLPGLINVAAFVPGVAQTGSHDFSLVTKASIAAGFSMIRVMPVGIDSAITDVRSLKIAQQNAEGGSYCDFNYSVAATDSNSEQIVHVKGEVGSLFIPFNHLAGNINKVATVTAHFGTWPEYKPIVTDAKTTDLASILLLASLHGRKVHVMNVTSKDDISLIALSKEKGLKVTCDVSIYSLFLSQADYPDCPALPTAVDQKALWDHLSAIDVFSVGSIPYQIAGDHAVPTVGLADALPLLLTAVSEGKMTMEDVTTRLHDNPKTIFELHDQNNTSIEVDINRPYVLQAGSAWSPFVGKTLRGAISRVIFQGKTACLDGELSLDGPRGVDMSSHLLTPPTPAVGPTSPILRAQVDASVDRRPTMFEATANRRVSTTVRSRPITRARNMDEVLDDTNSPLLPTAAFRQPTAPSTISPSLLSLLASSPFKNRHVLSVNQYTRQELHVLFTVAQEMRLGVQRQGIVPILPSKVLCTMFYEPSTRTSASFDAAMQRLGGRTIAINTDHSSTQKGETLQDSIRTLGCYGDAVVLRHPDNESAATAAKFSPVPIINGGNGSREHPTQAFLDLFTIREELGTVTGLTVTFTGDLKYGRTVHSLVKLLQYYEVRINLVAPKDLALPEEVREQIISSGQLAMESETLTPEIVAKSDVLYCTRVQKERFTSLAEYERLKDSLIVDNSVLKYAKSTMVVMHPLPRNREISEEVDFDQRAAYFRQMRYGLYTRMALLALVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJZ7</accession>
    <name>A0A0D1ZJZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PV08_08334</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233363.1">
        <property type="nucleotide sequence ID" value="XM_016382660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZJZ7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZJZ7"/>
    <dbReference type="GeneID" id="27335417"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08334"/>
    <dbReference type="HOGENOM" id="CLU_014629_3_1_1"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="17">
        <location>
            <begin position="32"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="18">
        <location>
            <begin position="289"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="16">
        <location>
            <begin position="512"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KIW13147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="699" mass="79090" checksum="0F1A224C8AB16AD0" modified="2015-04-29" version="1">MPTNPAWVKALKPSGPQGSELLQQERAKSNLNVDQLAEFMFTKEILERNERILNILAADPVFDKSQNYFRGRTERIEAALARGKRLQQLQVKHKWSRDEFQVANELISEPTPYGLHSTMFLVTLREQGTPEQHKLFLEKAEAYKIIGCYAQTELGHGSNVRGLETIATWNPEDKTFTLHSPHLTASKWWIGSLGKVANHAVVMAQLYIGGKNYGPHPFVVQIRDLKTHEPLPNIHVGDIGPKFGYNTMDNGFLLFKEVKIPHINMLARFSRIDPDTNKYIRPSNPSLIYGTLTWVRSNIVLQSGSTLARGVTIATRYCAVRRQFQDRDAPANEPGENQVLNYTMVQVRLLPLLAATYALHFTGKGMISLYEENQKRMNGNVGKPSDANRAPGPEELNPGTDLLADLHATSCALKALASTTAAEGLEVCRRACGGHGYSSFSGIGSWYADYLPTVTWEGDNYMLTQQVSRYLLKSARSVLKGKAAGNDTTRFLTEFVRRRDIGAAFDVIGNDQDLVDAFSWRVAFLTFEALRHRDEDKQSWNSLLVDFWRLSTAHAQYIIVKNFHEALNDSKTTAQLDPDTVSLLHKLFRLYALHTLEREASEFYSSAAVTVRQITLARTKAVMKLLEEVRPHAVRLVDAWKFPDWQLDSSLGRYDGNVYEDMFHRASEVNPLNSIVFDPYPDSKVLFKKDERENLRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZL72</accession>
    <name>A0A0D1ZL72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233763.1">
        <property type="nucleotide sequence ID" value="XM_016383060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZL72"/>
    <dbReference type="STRING" id="91928.A0A0D1ZL72"/>
    <dbReference type="GeneID" id="27335818"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08735"/>
    <dbReference type="HOGENOM" id="CLU_016972_0_1_1"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237847" description="endo-1,3(4)-beta-glucanase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="8">
        <location>
            <begin position="15"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="369" mass="39724" checksum="F5100D5715737BAD" modified="2015-04-29" version="1">MLCILSSVLLVSVFLKPALATYQLVHDYSGDAFWTGFDFFTDHDPTDGLVQFQSMEVANATGLAGFIETGTPSKAVFMGVDTAQVAPQGRASVRVSSNETFQHALVIADISHMPGGICGVWPAFWMLGSDWPNNGEIDIVEGVNDQTANSMTLHTNSGPIITDGAHFSGELVTADCDVNAPDQPKNAGCSIGDSSNLTFGSDFNSAGGGVFATEWTSQFIKIWFFPRGSFPDDIVSSNPNPGENWGTPNSVFQGSFNIDDHFKNLQIVFDTTFCGQWAGQVWNTTSCASLAPTCEDYVSNNPKHFIDAYWAINTLQVFQDDSEPAANSGPGRGTFNPPFNPSSTRNKSKRSPVAPSTANSGRRVLPIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZMF4</accession>
    <name>A0A0D1ZMF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234193.1">
        <property type="nucleotide sequence ID" value="XM_016381091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZMF4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZMF4"/>
    <dbReference type="GeneID" id="27333841"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06758"/>
    <dbReference type="HOGENOM" id="CLU_031973_0_0_1"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="59"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="596" mass="66427" checksum="8CE0B9B12824068F" modified="2015-04-29" version="1">MTSALMPAYTDRVAYGSHSARYSHHPYHQERPPLLSTDVDAIVGTAHVQKAGAFVPRTAEDWNVHRDVISSLYEELPLREVQRIMETNYNFKATKRMYNTRLKRWDIWKNYRAEEKEELAGRIAQAHVENRPIDTINFRNKPVKVNRVLRHCRTTARKRRGSTTLEVSKVKKGKGSEASSEDSTDSNRGSTDRDEMVRVPRSLGVNMTRRTPRSGSSSSGFVLLTPESGDTSATILTPSASGLSDNEVVPYITGGQATQEDQVPSPDPPIFPAKGPINVELILNQTQTYYLAHLESIRSEATDIYNVTAASNLFWSNVKSAIYFLKMKTPTLAWPLFNEACGLVGDVLSNSPILFLNSVFAVLSPVNTRICPLARSTLLRHLSNMASIKLTPLHPLAILFREIAQEDEFGFTSETAMLVTLNLLRQHLGGDHTGTFTVQRSLISLLRRDQRLVEAKQQSEELVRTTEQALVSQVGLAIQAKKPTSISMTELCIAMTELVHVYIDMKEYAVAKDICDKVIQNYKMIQGPSFPDSRAAYAMEDMAQLSEQLGDNGGATYWLGQAMEASCLLRGESDAATQHVKNKMDELVKKMVVTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZSD1</accession>
    <name>A0A0D1ZSD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235953.1">
        <property type="nucleotide sequence ID" value="XM_016380126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZSD1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZSD1"/>
    <dbReference type="GeneID" id="27332870"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05787"/>
    <dbReference type="HOGENOM" id="CLU_025201_0_0_1"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="180"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="283"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="374"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="528" mass="56166" checksum="6D6F36AE522948B3" modified="2015-04-29" version="1">MSDLSNILAALAAQQRQGGTPSQAPPPLPGAGFPPPQYATPPGGAPPAYGLPPPISSGSVDLAGIKPVSSGSVSIADAIAKARGIAAEKGIPYDPSRPPINTDPRSGSRAYRRSRSPSRSPPRMNRDSYRDSYNPYRDERRGNERAYTRERSLSPRGGRYSPARFRDDRSPGRERGAGAEGESEVLPLEKGVVGLVIGRSGENLRRIENTTGARVQFLDGPEVAGTQRHCRISGSRAARSAAKAEIFRVIDDNDVAKRGGGGGGGGPEKSRGPSKASVPTSKDGDSLQMMVPDRTVGLIIGRGGETIRDLQDKSGCHVNILGENKSINGLRPVNLIGSVSAQQYARDLILEIVESDQKGISIKDLHREREETQGKISETVYVPGEAVGMIIGKGGESIRDMQNQTGCKINVSPASGRDVEREIGLIGSRHAIDAAKRAIMDKVDTVRARSQARDGRDDYTDRYTSQQQPSYPPPGASTPAQPAAPPPAAGAADPYAAYGGYQNYLQMWYAAMAAQQQQQGGQGQGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZSD6</accession>
    <name>A0A0D1ZSD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235958.1">
        <property type="nucleotide sequence ID" value="XM_016380131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZSD6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZSD6"/>
    <dbReference type="GeneID" id="27332875"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05792"/>
    <dbReference type="HOGENOM" id="CLU_050072_0_0_1"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="33239" checksum="8ABE9EF959F2D9E6" modified="2015-04-29" version="1">MAAAITKLPPVRRSPTTLQYLEYKHKVKLDKPYFKPRFTFKSEDRKHTLLRPEFRFTDPLMPPYPYGKNAAFREANFGLYGGATLQSGNKISKGRNKGKTLRKWFPNVRIENFKSDALDTELRIPVTARVVRTIRKCGGIDEYVMGTKPARVKELGMLGWKLRWLVMTSPKMLARFDKERAELGLPQSTSLRAAFEDVWNDSDQRAKLLQQQELAWSDLRQAASRFEEHVRKHWIENGEEVDYEIPEMHTLRRRSPTSYILPEQLEGNLSNDVEKLTLEEPTAQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZUH2</accession>
    <name>A0A0D1ZUH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_06469</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236633.1">
        <property type="nucleotide sequence ID" value="XM_016380806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZUH2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZUH2"/>
    <dbReference type="GeneID" id="27333552"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06469"/>
    <dbReference type="HOGENOM" id="CLU_029499_3_0_1"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="11">
        <location>
            <begin position="310"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW16417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="440" mass="48517" checksum="10B81A432C2CF58F" modified="2015-04-29" version="1">MLKVPSRNKASGPNAVTKAVILVGGPSRGTRFRPLSLDLPKPLFEVAGHPIIWHCLKAVSKVPDIKEVILIGYYDESVFRDFVKDSSKEFPQIKIQYLREYQALGTAGGLYHFRDAILKGKPDRFFVLNSDVCCSFPLEAMLKLFEEKDAEAVILGTRVGNDAATNFGCIVSDTHTKRVLHYVEKPEGHISNLINCGVYLFATECIFPSIRIAIKRRTERPRMISYPSSENIEASFIADPEEDGEKNEVLRLEQDILSDLADSNRFYVHETKDFWRQIKTAGSAVPANALYLAKAFQSQSDEIATPSANIVPPVFIHPTATVDPTAKLGPNVSVGPKAIIGAGARVKEAIVLEEAEIKHDACVLYAIIGWNSRVGAWARVEGTPTPVSSHTTSIIKNGVKVQAITILGKECAVGDEIRVQNCICLPYKELKRDVANEVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWW9</accession>
    <name>A0A0D1ZWW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237408.1">
        <property type="nucleotide sequence ID" value="XM_016378731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWW9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZWW9"/>
    <dbReference type="GeneID" id="27331466"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04383"/>
    <dbReference type="HOGENOM" id="CLU_013866_3_0_1"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="614" mass="68628" checksum="09A153635F20C820" modified="2015-04-29" version="1">MIAHQYNGLPWSQRGLQGVQDSPCQVRPNPTILQQLYAPASQLSRVILRRVEKQNTLRDSTSSSDSTSSNSPSNDSPAESSLSSGSGSGSSSLTPPSRGPKKPLQWVIYSAPSQTDESLRDSQLSTNELAADRALQTRHSQRDTRPSIGIMLKPDSEEAATCFFFHHYTGSIYDENIHNGFATMWKPQFVRAGLDSPLRLVTSAFTVNITMMWCLQGCDTRPARKLMTKALTATRKAIQDPTPNKMDELLMTILIFDLYDSMVQHYIPLPVTSGKHKEGALALAQIRGKTNYDNPISAGLAKATRSTLLLHALRTRTRLIPGAEKLFEDSLLPINKGSELELIVVRIVNLQARQWELRTSQPGQQQGQRRRRPCDDRHVYYKYEAIIREAIALDDQLVEWRQSVTDPNWLPQYVHRDEVAPSIRAAGFYGDRCTVWQELIFAEIANYYAQSRLANLQIIRQAFADAPSPEEAQEGGVSATAAEREKEMRQILLTTNATVQRVVDAVCDSVPCHLGDTTVLTNPLYSDQMNVPFKTVKNPATRTVTTVPADLPLYKSRAAASGGWVLFPYVCGVLRLAEPEDDAVPIVLRDGQLDWIKGQVKRMQKTFLYCDPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A1A3</accession>
    <name>A0A0D2A1A3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03041</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238968.1">
        <property type="nucleotide sequence ID" value="XM_016377398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A1A3"/>
    <dbReference type="STRING" id="91928.A0A0D2A1A3"/>
    <dbReference type="GeneID" id="27330124"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03041"/>
    <dbReference type="HOGENOM" id="CLU_006937_8_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="65013" checksum="D366E03E73191888" modified="2015-04-29" version="1">MPIKRDIADVTENTDNTENPTQGSPQNEGEVLDMLIVGAGFAAVYLLHRLRQHEFKGKIVEAGSDLGGIWYWNRYPGARVDSQYPVYALSIPEVYNDWTWSSHYPDHAELREYFKHVEDRLHIKKDCVFNSKVISAEWDDKTCLWTITCHTGAVFKAKFWTACTGFAAKRYIPDWKGIEDFQGVIHHSSFWPKEGVNVSGKRVAVIGTGATGVQITQEWAKEIGEDGHLEMWQRTPNLACPMNQKSLTKEEQAKLRDDLAARFSERNNYYNGFLYQWRENLTFDHSDEERDEFYWQLWKMGGFRFLMNNYYDMTRNDEANQKAYNFWRDRVRERVHDPRKAELLAPWERPHLFGGKRLSLEQDFYDHFNRPNVDVVDVRNNPIKCFVSDGIIQEDGTHHKLDIVALATGFDSITGGLKDMKITGVDGEVLTEKWAKGTWTYLGISTASFPNFFFTYGPQAPTAFSNGPSCIEIQGDWITSVLNDMRAKSFKKIDAKRKAEEDWRALIFELIHDTPRGKVDSWYNGANIPGKPREHLNYAGGIPRYKKTLEKVRQDGYEGFTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A213</accession>
    <name>A0A0D2A213_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin Pex22-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239188.1">
        <property type="nucleotide sequence ID" value="XM_016377618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A213"/>
    <dbReference type="GeneID" id="27330344"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03261"/>
    <dbReference type="HOGENOM" id="CLU_025740_1_0_1"/>
    <dbReference type="OrthoDB" id="5327700at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="54145" checksum="D5780065ADD534BB" modified="2015-04-29" version="1">MSYQYTVTERRRRTTNSGYGHSGHRSTFGYWVPLVVTVTAAAIGVAAWVWSERRDDEEESSEEEHYPGGVPPPGYASMSGALPAGPPPPGGYQGPPGPGPEGFQGPPMMPGPNQPGGFQGPPPPPGVQGPGPEGYREARGEYYASRPTVEEQQEETGFVARMSSALGFGRSTTPSQSLTRGDPVQQPYDWTNKPFASGVAAAGAMVGAAISSIRGDGGEGYEDHERWSEEVEQRESAQDVKQGIKRRGTADEFFSGKVDIPRESSIARQKRKAVAVVVSAAGLGSDGDVDHASILSYLPEYVDPDTTRVFVLIYAPELKAHPLGNRIPSQSMTSSFSNISQAEAHTPAHTPGDFPSGTPDDGILAHVDPKPVEDGTSAYKILRDQALTIVDRETMILPFTSSRGHKHILRSLAPELVYIQESLCGADGEIVSELSGWVRQTVVVIGDEGGQGGLVDTDDESVTHRPETWWQKEERTGLGKRVGVVESLKIGEDWQRRINDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A441</accession>
    <name>A0A0D2A441_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239833.1">
        <property type="nucleotide sequence ID" value="XM_016374557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A441"/>
    <dbReference type="STRING" id="91928.A0A0D2A441"/>
    <dbReference type="GeneID" id="27327273"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00190"/>
    <dbReference type="HOGENOM" id="CLU_032489_0_0_1"/>
    <dbReference type="OrthoDB" id="4146035at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="53698" checksum="F788342A30337B0C" modified="2015-04-29" version="1">MPEIFSPVGSGQNDPFAVYPFTSSNDDCKLFQFFHNVVAEVIYGYGPAAPLCYLRSVTHHFVHDDAIVQLILAFSSFAWSSLSMERKRYERTGVIHKAKGIQALNRRLGEPHHLISDSDIQAAIIMSAIEGRAGNLKAFKIHASGARSMIKLRGGLDKLDPLLVWQICSSESRIFEVVGVEMFPCTDRHFGRFLLRCRPDVAVCHAAFRRKSAASKPPLEEIENFVEPLDLPPDLFLSACVTEFVMVTAQFQELSEERLGYRRNPSPGGWRGLSFAPTQWASISDIFCSTLHPILSPSRQILESVTISQNSTASELYTHDTTRLICLLHIHTMLWRYRDNPTQAEIYMLRIELEIKRNGLGATKSLDALHWVLVWICLNSDGLHPDQDELGWKELTRMIARLMRVARCLSRRSWKILEYALFESLGARRRLYLEDLDATQEPSKHPEEEIEWLEPEVVWEESMAEPPSWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4V7</accession>
    <name>A0A0D2A4V7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_00437</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240078.1">
        <property type="nucleotide sequence ID" value="XM_016374802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4V7"/>
    <dbReference type="STRING" id="91928.A0A0D2A4V7"/>
    <dbReference type="GeneID" id="27327520"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00437"/>
    <dbReference type="HOGENOM" id="CLU_078274_0_0_1"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="11">
        <location>
            <begin position="73"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW19862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="244" mass="27759" checksum="ECD7AB093F0179F0" modified="2015-04-29" version="1">MAFPHAPGLLPAEVAFLCEMEQITVVPRQRLDRLDLLGGPTKALIPPQRTTLPLWLAILLKRQRRTNIIPPPWLSTESLEEILEIETRHFTETFSPAPQIPATRQTDYSGRPFYASPPFVGSCTANAAPTALPYHWYELSEILLESASDDVSDPDRVRQLLRDIREVRLAKMRKEVDQLSGDGEGTRLDGVGAMEISESRGFVTGVMDGLRKLDASREQARREREEEERENRRYDDDDEDDEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4W2</accession>
    <name>A0A0D2A4W2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240083.1">
        <property type="nucleotide sequence ID" value="XM_016374807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4W2"/>
    <dbReference type="GeneID" id="27327525"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00442"/>
    <dbReference type="HOGENOM" id="CLU_166271_0_0_1"/>
    <dbReference type="OrthoDB" id="4509278at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238164" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="12095" checksum="BE7C75FAB1DF6EC6" modified="2015-04-29" version="1">MFSLKSSFIALLPLLGSLSSLTSASPIDARQSSGVSVTFIGAADAQYTLEIPANSVFTPTNNALSISHIQTSAGGPCAFFGVDGAVFVAPPSGGYGDVGPPQTIAGGICGPFPGHQYGMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8Z3</accession>
    <name>A0A0D2A8Z3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLP1</name>
        <name evidence="13" type="ORF">PV08_01842</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241478.1">
        <property type="nucleotide sequence ID" value="XM_016376202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8Z3"/>
    <dbReference type="STRING" id="91928.A0A0D2A8Z3"/>
    <dbReference type="GeneID" id="27328925"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01842"/>
    <dbReference type="HOGENOM" id="CLU_018195_3_1_1"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="11">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="12">
        <location>
            <begin position="128"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="10">
        <location>
            <begin position="355"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="131"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW21262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="503" mass="54266" checksum="5A64809496C39D37" modified="2015-04-29" version="1">MSLPGLGLSEPEEVSTVETQQHDLAKECEWRFEVAVGKYIHVKILSGNAEIFGTELVVGNTYIFTGTKAAIYTWNGCAFEVSGDALQSEYKAEETPMNEYVNVHFALENIREQAKALGREGPRVLILGPDDAGKTTLAKILTGYAYRAARSPAVVNLDVNEGMMSIPGTLTATVFKSMMDVEEGWGTAPMSGPNGAIPVKLPLVYFFGSSKPEEKDGKVYRAQLNRLALAVAGRIGQDQEAREGGLIIDTPGELTNTKVGAIGYDIIQDIVSEFAVSAIICLGSERLYSDMVKRFDGQLTSSRSTGGSTGTISVIKLAKSGGCVDRDEAYMRAFRAAQVKTYFYGNPRLSNGVSLQPRQQQVDFSTLTVWRRISSTPDPTATTFPGDEDEDTFLPGGGMDNEIAAPGAGGGLSKVPLPSSQIYERMAAPYAAMRSSILAVMNCEPEAEQETIRDSSVMGFLYVTDTDEARGRISVVSPVAGRVPHRAIVWAGWPEPILGLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASL0</accession>
    <name>A0A0D2ASL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Tryptophan synthase</fullName>
            <ecNumber evidence="3 10">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_12046</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="3 10"/>
    <dbReference type="EMBL" id="KN847504">
        <property type="protein sequence ID" value="KIW09703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229919.1">
        <property type="nucleotide sequence ID" value="XM_016386353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASL0"/>
    <dbReference type="STRING" id="91928.A0A0D2ASL0"/>
    <dbReference type="GeneID" id="27339129"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12046"/>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_1"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="12">
        <location>
            <begin position="70"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW09703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="408" mass="44033" checksum="93814470F19F649B" modified="2015-04-29" version="1">MPYLESDESNLNENRTGEASGRFGRFGQFGGQYVPEALKESLIELDEAFVQAKADPDFWKEWRNLSPYTGRPSPLYHADRLSQHVGGAQIYLKREDLNHTGSSAINNALGQALLARRLGKRRVITQTGSGQHGVAMAAICSKLTLECTVYMGVTDARRQSVNVVDMKILGAEVVVVGRCAGALRDAMNEALRASIHDLDRSFYATGSSIGPHPYPIMVRTFQSVIGQETKDQIRDLTGRLPCAVLACVGASNSVGMFFPFRSDSDVNLIGVEAAGHGIDTDRHSAALGSGAVGVYHGAMTYLIQDEHGQINTSSSIAAGLDCPAVGPELAHWKDSARASFVTVTDVQALVAFQSMAQLEGILPSLETSHAIWAGMKMASTMKLEETLVICLDGKGDKDLEVVADRLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATN0</accession>
    <name>A0A0D2ATN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230294.1">
        <property type="nucleotide sequence ID" value="XM_016385350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATN0"/>
    <dbReference type="STRING" id="91928.A0A0D2ATN0"/>
    <dbReference type="GeneID" id="27338121"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11038"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF238">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="427" mass="47535" checksum="762F6D02F2BDE3BE" modified="2015-04-29" version="1">MVQTVERERLSILIVGAGLSGLAAAIGCSTGGHSVDVIEQAQELTEVGAGLQITPNATKILGQWELPQSFWQATAEPKTLSVHRYSGELLAHEEDFHGKMRRKYGAPFLDSHRADLQQALFARAVDLGVNFHFGRRVETIDFSGPMVKTESGETYTADLIIAADGLWSRCRECFLGTKDDPIPTGDLAYRIVLKAEEVRNEKLRAVIENPQVHFWIGPGAHAVGYSLKAGKAYNIVLLVPDDLPPGIARQPGSVEEMRELFKGWDPILLEFLKYCDKADKWKLMHHEEMPSWINEALNLVFIGDACHPMLPYLAQGANSSIEDGAVIGGLLAHVKKKSDLPGLLRLYADLRKPRGEAIALETFKQRRDFHLPDGEEQRKRDEIFISQLGKGLQGAFPSRWTCPQVQPWLYGYDAMKEVQNAVNSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AW25</accession>
    <name>A0A0D2AW25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_10232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231149.1">
        <property type="nucleotide sequence ID" value="XM_016384547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AW25"/>
    <dbReference type="STRING" id="91928.A0A0D2AW25"/>
    <dbReference type="GeneID" id="27337315"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10232"/>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_1"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000025">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF11">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="14"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW10933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="534" mass="58942" checksum="EADF208DE04AB4A7" modified="2015-04-29" version="1">MESIKLPEFKTTPVDEIPAIVSRLRQTFYSQKTRPAEFRIKQLRKLYWAIEDHKEELVEACRRDMNKGHFEAMAGEVNWVQNDIVFQTQNLEKWMKDEKPPDIALTNRLVSPRIRKDPLGVVLVIGAFNFPVNLSFGPMVGAISAGNTVVLKPSESSPNSAAVMQKIMEESLDPDCYACVQGAVPETSALLDQKWDKIFFTGSSRTARIIAQAAAKNLTPIALELGGKNPSFVTKKADPRLAARRLLWAKTMNAGQLCISQNYILVDKDVVPSLIEELKIAMKEFFPDGAKKSKDFSRIINTAAFNRIKKMVDNTSGKIVIGGTMDAEELFIEPTVVLVDDPKDSLIVEESFGPLIPVLPVDNLDQALQIANETHETPLAVYAFGSKEETKKILDGTRSGGASINDALFHGIVPNLAFGGVGDSGTGAYRGKASFDCFTHQRSITSTPGWMEKLLAVRYPPFYGTDKLKQFNKMGLIAPDFDRNANKKVGWLWWLLTLGTASASKGVSRAALVAGLYVAITMLMQRRALRTALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWT7</accession>
    <name>A0A0D2AWT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PV08_10209</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231126.1">
        <property type="nucleotide sequence ID" value="XM_016384524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AWT7"/>
    <dbReference type="STRING" id="91928.A0A0D2AWT7"/>
    <dbReference type="GeneID" id="27337292"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10209"/>
    <dbReference type="HOGENOM" id="CLU_006515_2_0_1"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002774">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="4"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KIW10910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="831" mass="94092" checksum="A855B015D2637C0A" modified="2015-04-29" version="1">MEPSQEDFYHPYQPYAIQLEFMTNLYKCIEERKVGIFESPTGTGKSLSLICGALTWLRDHERRRFNDTNAQADASDWLLQAEFAAQRRELMLEREELERKLSKLRDEENRQKQTRIDAKGFKKARTAVVQSQITEDIDFLVDDYESDSERTAASQTSEGGFSSSTQALLDKLRPSYKATEIEEPSDRLKVIFCSRTHSQLTQFVNELRRVKPPSSMELTADDASQTSKMQERVKHLALGSRKNLCINPKVLQLSSTAAINERCLDLQKPGIAKEKKCPHLPSKEDKERVAAFRDRVIAQIRDIEDVGNLGRDMNICPYYASRTAIAPVEVLTLPYPLLLQKSARDAMGISVKDNVVIIDEAHNLMDAIADTFSVALRLSQIEQALRQMTAYAIRFKQRLKGKNRVYVTQVIRLLNSLIDCLQVVTEKAHSHELTVTAGKLMSGKGADQVKPHKLLQYLHESKLCHKVEGYSESQTDGKCNTVKGSMMQFQNFLTVLMNPDDEGRFFVSRQGEDIVVRYTLLDPREHFRDIVEEARAVILAGGTMSPMSDYADYLFSYLDRERLELFSFGHVIPTSHLFAQAVVKGPSNIDFDFTYERRGSELMIVELGNMVLRTCTVVPDGVVVFFPSYDYLAQVVSVWQRRPASYPLMQSLAAKKTVFQESKGAAVDDLLRDYAIAIDSGKGGLLLSVVGGKLSEGINFSDKLGRAVIVVGLPFPNAHGAEWKAKMQHIEELQYQQCRKAGRTEAESRAAAKSASRDFYENACMRAVNQSIGRVIRHRNDYAAILMVDRRFSTTRIRQKLPGWIKDSMHNSPLEWKVAEEGVQAFFEAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AY53</accession>
    <name>A0A0D2AY53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231571.1">
        <property type="nucleotide sequence ID" value="XM_016384969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AY53"/>
    <dbReference type="STRING" id="91928.A0A0D2AY53"/>
    <dbReference type="GeneID" id="27337738"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10655"/>
    <dbReference type="HOGENOM" id="CLU_033465_6_0_1"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF11">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW11355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32138" checksum="0A2DC30244A44043" modified="2015-04-29" version="1">MSTRRENTPACAAYNRALDPGNYGYHPSLAAGVVFSTIFGLIAIGHLVIVMRTRVYWIVLFSIGATIETIGWVGRAIGYHCPYSRSLFLMQTATLIMGPSWTQAGIYIALWVLVRGLGRKTSPFSPTVYLFGCFVADVVCLSLQATGGGLAGSAYSKHESTDPGTKTMVAGIISQLGVAVVFCFLFAVVVHRGATQLRDPGNRKLWHITIAIVTAISMMIMRNVYRSIELLQGWRGYLITHERFVVGLDAVPMTISMATFLVIQPTMGLIKRKVHDQGSRPETTLTESSREKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYH5</accession>
    <name>A0A0D2AYH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231984.1">
        <property type="nucleotide sequence ID" value="XM_016383361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYH5"/>
    <dbReference type="GeneID" id="27336123"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09040"/>
    <dbReference type="HOGENOM" id="CLU_066708_0_1_1"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="33"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="252" mass="29103" checksum="BB1067A6CE744F18" modified="2015-04-29" version="1">MSPQWADQPYGLLSTEPFSKDSSNGAYYTATQMALAHNGILRGLNSIYLQAIHIPTGDLATVKDFLTYCQCWCESMHHHHDAEENTFFPSIERLTGVPGLMERNREQHRAFTPGFDHFNEYVRTCLPKDYDGKTIKTLIEEFAGPLTQHLHDEVETLRALDKYDGEQVRQAYRRLEKILMDTDNYRIAPLVFGTADRSFEGGRHDFPAVPFFVPYIIQYVFARRNRGVWRFNPCTIWRDPRELAYTGARAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0H7</accession>
    <name>A0A0D2B0H7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MmgE/PrpD family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232659.1">
        <property type="nucleotide sequence ID" value="XM_016384036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0H7"/>
    <dbReference type="GeneID" id="27336803"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09720"/>
    <dbReference type="HOGENOM" id="CLU_026574_0_0_1"/>
    <dbReference type="OrthoDB" id="4120269at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="397"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="61823" checksum="001B2D197A005BBC" modified="2015-04-29" version="1">MSHSNGDASIQMPQDHLQTQTGVDETIELPSLTQLAVQHLEKIRKGRLSSEVRDKTVLCLLDYLGALVSGLSAPWATSLLRYAQVSSGGGGGGSPGPGTSSQSGSNVMGLATRCSAETAAFTNASIAHSIIRDDMHLAAGAHIGVMVIPSALALAQRDHWSGEQLLKAVVGGYEMAVALGSAVRHSGTCNPHFRPSGIVGAFAGASTGIVADPTITSAQAAHALGLAANMAAGLNEWPWAGGVEMTTQMGAAARAGITSYDLAKAGMGSSLSVLEGKDGLFAAYGCGDRDVAATFFRNWLHAADAESKNDKAAGGGVSYGTGIMGVKFKPVAGCNFIQTPVSVALRMHDSLYVDVHAKAKAKVNFQVNLDLKLNMPVTGMTPIMSTTTNTNTDAIVDVGDIDRVTIVTTSLARAYPGCDHAGPFEKVQQTKMSLQYGVCAGLLFGRVDEWTYLQFSNEDLISLLGKCVLETDAAFDEDLHKRGRQPCRLEVRMKKKGNGAQLVHRDFMADVPWLNDTPGAAVEERFRKEVAAIFDRRAPPDVTNRDVVDDIVLECRRLLENGSSSGTERLFDLLASPPQGLPVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0X6</accession>
    <name>A0A0D2B0X6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ER membrane protein SH3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232566.1">
        <property type="nucleotide sequence ID" value="XM_016383943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0X6"/>
    <dbReference type="GeneID" id="27336710"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09627"/>
    <dbReference type="HOGENOM" id="CLU_080510_0_0_1"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029187">
        <property type="entry name" value="Shr3_AAP_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24211" checksum="C85997848743B8BE" modified="2015-04-29" version="1">MPSNPFATFLIICPVSFFLGILFSLFPYDYPLLWSSLPTPDSHFDAIESHLKLLHNAPNLIQRILHIMLSAGLLGLIIKLYKPSESNMLFDGGSLVLYMVAVIVYIANIVKGLRIVTDGSYGVVPDAVDTPGYDADAVDSVVGREDNLKVLAASNTILALVLVGVLVLQVGQWYAERVDERALKDFHEKEKLEQEKKEAESPPSAAVKRQGSSREGKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B1K6</accession>
    <name>A0A0D2B1K6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232716.1">
        <property type="nucleotide sequence ID" value="XM_016384093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B1K6"/>
    <dbReference type="GeneID" id="27336860"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09777"/>
    <dbReference type="HOGENOM" id="CLU_2757797_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="70" mass="7413" checksum="3B9269CC5E1D82EC" modified="2015-04-29" version="1">MSNFVTKAKEGAYQTSNEAKADDTCDLKNDNSHKPKSTDKIEAGKGSGSGSNQDDREGPHAKAASKEDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B214</accession>
    <name>A0A0D2B214_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_08125</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233154.1">
        <property type="nucleotide sequence ID" value="XM_016382451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B214"/>
    <dbReference type="STRING" id="91928.A0A0D2B214"/>
    <dbReference type="GeneID" id="27335208"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08125"/>
    <dbReference type="HOGENOM" id="CLU_031246_0_0_1"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="26"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="236"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW12938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="412" mass="46125" checksum="AB4713E055537303" modified="2015-04-29" version="1">MDVPKPGEWPVDPQEDQEPRKDRIWVDGCFDFAHHGHAGALRQARQLGKELYVGLHSDEEILVNKGPTVMTLNERVAAVDACRWATKSIPYAPYVTSLPWISHYGCWYVVHGDDITSDAGGEDCYRFVKAAGRFLVVKRTAGISTTDLVGRMLLCTKTHFIRSLMDELKSNDDGAEKLQKIKEYATDETALNPGCEVWNWAQASHDKSLHETIDAGTFSNIVSGNGPKPGQRIVYVDGGFDLFSSGHIEFLKRVNEAEKGEAYVVAGVHNDDVINHWKGFNYPIMNIFERGLCVLQCKYIHAVVFGAPFVPSIPYLESIPFGKVDAVYHGPTSYLTSSFDPYTDAKKMGILRQIEAHPYAHVNAEEIVGRILKGREAFEERQRRKGQKAIGEEAAREKELLEQRQSEAGVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2B7</accession>
    <name>A0A0D2B2B7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232981.1">
        <property type="nucleotide sequence ID" value="XM_016382278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2B7"/>
    <dbReference type="STRING" id="91928.A0A0D2B2B7"/>
    <dbReference type="GeneID" id="27335035"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07952"/>
    <dbReference type="HOGENOM" id="CLU_2133553_0_0_1"/>
    <dbReference type="OrthoDB" id="3439190at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12533" checksum="41A30A7DE3A773CD" modified="2015-04-29" version="1">MSSSKAPIRSLSPIGSVRSAAPGAPTPGPTSTVISSYGNYSNHGKDNTKVDVFYGSREKLRLFVTQLIATFKLNRTRYVTHEDKVLFAGLYIRGSAFYWFEPIMMDYMTSPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3K3</accession>
    <name>A0A0D2B3K3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233461.1">
        <property type="nucleotide sequence ID" value="XM_016382758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3K3"/>
    <dbReference type="GeneID" id="27335515"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08432"/>
    <dbReference type="HOGENOM" id="CLU_978444_0_0_1"/>
    <dbReference type="OrthoDB" id="4148416at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31715" checksum="581DBC64489EFD22" modified="2015-04-29" version="1">MKFTTRRVSTGTGFAISRPQLQTTFPPPPVPAPSRTSRRPQDRALHQLHEFRTIGLPMLLVLVFTTLILNAIYAYCVAKPHTDIAERLSKDATAEANGSIFRRSGSLRVFSDAHLLATRDNAAASTGTSSTSEVALLFYTLFTPCMSLVHLCFELTAHHATPRHLRSKAAFLVLTPSAALFVAGWVTTLSFWMHCELPSLNSNPAGQAVCPAQVRGHFMYGIHEVSIAKIAVGWVVSLAYALHVLVLARAWRIGGSGSGSGSGNEALEHGETATHATEIAVGLDMKPRAQYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3P1</accession>
    <name>A0A0D2B3P1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial DNA replication protein YHM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233704.1">
        <property type="nucleotide sequence ID" value="XM_016383001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3P1"/>
    <dbReference type="STRING" id="91928.A0A0D2B3P1"/>
    <dbReference type="GeneID" id="27335759"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08676"/>
    <dbReference type="HOGENOM" id="CLU_052717_0_0_1"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000053">
        <property type="entry name" value="Mitochondrial DNA replication protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000085">
        <property type="entry name" value="Tricarboxylate carrier, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="121"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="222"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW13488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="319" mass="34351" checksum="6085CDB022C12576" modified="2015-04-29" version="1">MSAQQQVLGTSAAPGVTKIEKKPVKFSNLLLGAGLNLFEVTTLGQPLEVIKTTMAANRKDSFAGAMSRIWGRGGILGYYQGLIPWAWIEASTKGAVLLFVASEAEYYAKTFGANNFVSGITGGMVGGVAQAYATMGFCTCMKTVEITQHKLAAQGVKPPSTFKTFADIYRKEGIRGINKGVNAVAIRQTTNWGSRFGLSRLAESAIRKVTNKEHGEKLSGFEKIIASSLGGGLSAWNQPIEVIRVEMQSKTNDPNRPKNLTVGKTFKYIYESNGIKGLYRGVTPRIGLGVWQTVCMVALGDMAKEAVEKLTGDKVTAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3U7</accession>
    <name>A0A0D2B3U7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08751</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233779.1">
        <property type="nucleotide sequence ID" value="XM_016383076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3U7"/>
    <dbReference type="STRING" id="91928.A0A0D2B3U7"/>
    <dbReference type="GeneID" id="27335834"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08751"/>
    <dbReference type="HOGENOM" id="CLU_006332_4_0_1"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249450" description="Arylsulfatase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="29"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="566" mass="63722" checksum="FC8C1CE1B5898032" modified="2015-04-29" version="1">MVPILTWAYVSFLLLSVSWASKCPTKKKPNIIFILTDDQDLRLHSLEYQTQTMKHLRDGGTSFEKHFSTTAVCCPARVSILTGKMAHNTNVTDVYPPWGGYPKFVQEGYNDKYLPVWLQNAGYDTYYTGKLFNAHNLANWNKPLPAGWNQTGFLLDPGTYTYYNTCIQMNDQPPAFRPGEYSTDIIANLSLSWLDMAAKSSRPFFLGLAPIAPHTESIIGRGNSVWFDVPRPAKRHENLFLDSKVPRGPSFNPEEACVSWVKELHRQNQSVVDYNDSFYVKRLQSLQAVDEMVGALFEKLKALGMDQNTYVIYTSDNGFHIGQHRLNPGKQCAFEEDVNVPFLIAGPGVPKNHSVSFTTTHHDFAATIFDLAQIPLRQDFDGTPMPLTLHAMDKVAVSTIREHVAVEYWGVAGEEGALYRSGVNGSFTPHANNTYKGIRIVSPQYDLMYTVWCNHEHELYDMKTDPYQTYNLFQTFVQINGQPVNNVVSRLDALLMVMKSCKASQCVEPWLTLHPDGKVTHLIDALDPSLDSFYASQPKVAFTECALGYIIAAEGAMNVDPYHVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4D0</accession>
    <name>A0A0D2B4D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">O-acetylhomoserine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="12">2.5.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_08693</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:27822"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10048"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-acetyl-L-homoserine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="12"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233721.1">
        <property type="nucleotide sequence ID" value="XM_016383018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4D0"/>
    <dbReference type="STRING" id="91928.A0A0D2B4D0"/>
    <dbReference type="GeneID" id="27335776"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08693"/>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_1"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000083">
        <property type="entry name" value="O-acetylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="432"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW13505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="461" mass="49582" checksum="203257C74BC8FA6C" modified="2015-04-29" version="1">MSAGDHVSRFETLQIHAGQEPDPATKARAVPVYATTSYTFNDSAHGARLFGLKEFGNIYSRIMNPTVDVLEKRIAALEGGIAAVAASSGQSAQFMTIIALAHAGDNIVSTSNLYGGTYNQFKVMLPRLGIETKFLTSEKPEDFENAIDDKTKAVYVETIGNPRYNVPDFEAISKVCKAKGVPLVVDNTFGAGGYFCQPLKHGADIVVHSTTKWIGGHGTSIGGIVVDSGKFDWKANAKRFPQFNDPAPGYHGLKFVDTFGPLAFIIRVRVEILRDLGSCMSPFNAQQFILGVETLSLRCERHAENALKLAKWLEKHPNVSWVSYPGLESHPYHALAKKYLPRGFGGVMSVGIKGGSAAGAQVVDGFKLISNLANVGDAKTLAIHPWSTTHEQLSKQERLDSGVTEDMIRISVGIEHIDDIIHDFEQSFAASSAAQPDAAASADNATAESKPSTDAKLSGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9C3</accession>
    <name>A0A0D2B9C3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRO1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235714.1">
        <property type="nucleotide sequence ID" value="XM_016379887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9C3"/>
    <dbReference type="STRING" id="91928.A0A0D2B9C3"/>
    <dbReference type="GeneID" id="27332627"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05544"/>
    <dbReference type="HOGENOM" id="CLU_007181_2_1_1"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="4"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="854" mass="94987" checksum="2106B13352F7C399" modified="2015-04-29" version="1">MASNVLEIPFRRTHSVDLSSAIKQYISSKYDQSPGMFTDDLRGIDALRADAINVQEPHTSGLRRLTAYAAQLRYIGGKFPIDIGVDFPWYPAIGYDRDKPILQNNIRFELANILFNLAALYSQLSTHTNWTTIDGLKQAAEYGIAAAGVFAFMRTEIIPDMRSTPPEDMDDVTLDSLQSLCLAQAQECFWQITVKKNMSDGTVSKLAAKVSDYYIAAADASRQSRAVSSEWIHHMQAKHHHFAAAAQYRQSRYCLQNKQYGEEIARLKDSINCVNEGLQEARWVNATVVGDLNGLKTRVQEDLKRAEKDNDVIYLQAVTPKSELRLLDRTNMVAPKTPAEVANGISLLGEGQPFGKPLFEKLVPYAVHQAASIYEDRRDRLVNQSIIADLEAMTARLREVLQSLDLPGSLQALEKPLGIPGSLVSKAEELRQQDALYRIKRSIDDTTKLKTNDVAIYQEGVSLLDAEKAEDDRARSKYGTDRWNRPSSEVALAKLYQSSKELQTYLNSAAASDSLVQAKLRENEHILKVLSGTNRDLERFVPSSRQVEMTPAIEQAASRLRTCLNEVSRLETRRKNRINALREKAQADDIGPALLTEAARLEREFPMQKIEPGQFEGLFDRRLQTYDSDRDVLVVEQEEQDQIVARLREANKAFLEARRGDTSTRDRQKALQALDTGYSKYKELISNLETGRKFYNDLAGHVTRFRENCKAQVNERRVEASQLEAELAGQDMGRLNLEETRRELAGPQTRSRGQVASNPQQPQRKRQGQGHEDGAGAGQEGIISAPIPTRNHHPPPPSVEAAGVMPSTAPVSVNVAGGSIGGGGVWTPDIGIRFGGGAPANQPGQAGYPVPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAL0</accession>
    <name>A0A0D2BAL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235831.1">
        <property type="nucleotide sequence ID" value="XM_016380004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAL0"/>
    <dbReference type="GeneID" id="27332746"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05663"/>
    <dbReference type="HOGENOM" id="CLU_046319_0_0_1"/>
    <dbReference type="OrthoDB" id="4137691at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="489" mass="56297" checksum="610DE78F43E75A97" modified="2015-04-29" version="1">MQTLPQLCRRAALPNIGGRCLFGRNAFNSLRPSSSSRAARKPPNMKPVRDRQNNLTRLTKSPSPLDNYYITLALGQKLTKLGFRSIQTVVKLFNHHRAELQRAKIHHDRAVSTSLHNSQWTRTYEEALTSDEVALVLNPNVLPRIFEAFGEADFHRQNVGKFAQLGYYSLCCAFEAGDLEAAIKVAFIEHQSKKVSSRVSGFLKQHAAKMIDWRTMSLWCELATEMSHSKEGAEANYLLAKKLDAMLEPSNRLMSRAEMFERYRPTWSLVHDSANHYLSHFDRDDPEGDPVQRDLDNAIRDGVKKWKDPKAAHELLLMPGEVTKFSDRWLSLMTMSAMEGSAEHCVRLALYHLGKDGWLNHHLDENDHWVTSERKDKPKNWIGIEWLGLSAALENTDASLKTRRYLRLALLLREHGLDKDAIPWLTTAKDDLEDQGLDTDREWVEYIDGFAQHWYNDEFMTRKSEDDWFLEDFEARSKNDAVEESLQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCB2</accession>
    <name>A0A0D2BCB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236481.1">
        <property type="nucleotide sequence ID" value="XM_016380654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCB2"/>
    <dbReference type="GeneID" id="27333399"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06316"/>
    <dbReference type="HOGENOM" id="CLU_079904_1_0_1"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="2">
        <location>
            <begin position="69"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="265" mass="29708" checksum="0B6DB26F1F2C4C6D" modified="2015-04-29" version="1">MTRKVLFPQLQGGHGTNRGNPEPKPASKEDPDQRPVCTSIGKQQRQQQQQHRWETLLFMRPKSKLATHIVPAAHGFAFEVKASSHFRIVDLEGQQVVDFMAWALPYTRSTDCEHFSASYTRYALGGLAAPQEGECLYSNRDRKMFTLVADTVRTHDLLFMACNPGFYSRQGQPDHRSCATNFAEAMAPWGMEHWSDVIDPFNVFQNTPYYTLKALNSSKPGDYVEMRAEMDTVCAVSSCPYTGGGFNGGNVTRVAVVTEVVEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCX9</accession>
    <name>A0A0D2BCX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237039.1">
        <property type="nucleotide sequence ID" value="XM_016378362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCX9"/>
    <dbReference type="GeneID" id="27331096"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04013"/>
    <dbReference type="HOGENOM" id="CLU_095017_0_0_1"/>
    <dbReference type="OrthoDB" id="4072826at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="260" mass="29300" checksum="F5793D58C21D3282" modified="2015-04-29" version="1">MDTSISTPRLQLTVITAAERGSPEFEWVHQLRSDKQATWWSILPRSETPEDTEKAIQKILPTTNTSLEAHKDALNIDDERRKAHRVTFAVHEIRNDDDGCNSGQDHNQGRVQRQAEHPRPHETRFIGLVALVHVDADNLVLPEHLSPSASETSLILELSYSFLPDAWGKGYATESVNAVLAACGRCVSLWSPYAQVYVRAIVNGENRPSLRVMEKTAMVKKGVYELNDRPVFLAGKIRQHHVLHIYGMYLVDQTITQGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BD57</accession>
    <name>A0A0D2BD57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236731.1">
        <property type="nucleotide sequence ID" value="XM_016380904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BD57"/>
    <dbReference type="GeneID" id="27333653"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06570"/>
    <dbReference type="HOGENOM" id="CLU_767339_0_0_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="191"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="361" mass="40912" checksum="4A0C7551B6385B44" modified="2015-04-29" version="1">MAQSYATMLCPELRSMPMPKEIGLATRVSLLEARFSLMNEMDHRAKSKASPGAGSAASSPGSTSQSFRYSSKYSQLPPEPVLRSLLDTFFRSCQNQPYVYFRQAVFYRRLEDKEYPDYLLLAMIALSARFSDEPFFESQQLAAVDFYGRTAWSEIFDQAFADDTQLLDIHMVQATNLLAVVDFTAGRHRLGWVKIGLAVRFAQSLQLNTEPRSDLPFEEQDERRLTFWSVYLLDRLASCGAYRPSTIADSDCSTLLPSDCPDAHQTMPGLRLLEEMHTIHETRHMDPFTYTILMASALGRVERQALQQQGSTDRYPPWDSRSDFAAIYSLLLSFEGYSRVTDASVSDAVRTHYLDLEGSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BD88</accession>
    <name>A0A0D2BD88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236766.1">
        <property type="nucleotide sequence ID" value="XM_016378089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BD88"/>
    <dbReference type="STRING" id="91928.A0A0D2BD88"/>
    <dbReference type="GeneID" id="27330821"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03738"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_1"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="128" mass="13801" checksum="16206EDB5B6065F0" modified="2015-04-29" version="1">MAGGELQVIFNDKGVHPIGPYSQAIKAGGFVFLAGQVPCDSQAKVVPGTMRDKARRMCENAKLMIESAGSSMDKVVKVNIYFEDIDRDFAAVNEVFAEYFVSKPARTSIQVAKLPVGCPLEMDVTAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFD6</accession>
    <name>A0A0D2BFD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_04908</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237929.1">
        <property type="nucleotide sequence ID" value="XM_016379252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFD6"/>
    <dbReference type="STRING" id="91928.A0A0D2BFD6"/>
    <dbReference type="GeneID" id="27331991"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04908"/>
    <dbReference type="HOGENOM" id="CLU_009681_0_0_1"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF187">
        <property type="entry name" value="EF HAND DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="9">
        <location>
            <begin position="282"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="422"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="458"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="530"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="710"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="874"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="845"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="882"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="927"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW17713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1057" mass="119774" checksum="37BCC75D4CEC3852" modified="2015-04-29" version="1">MSKYDYRKPLIIALAGATVLSVAFYAYTYTTTKPHVESTQSPTLHRSNAVRRPRHRRRWRPGFAPRPLNYDPAQRAVDNLGHRNHTGEGYGEYRNNWFFSETTDTEGSNLTLLPCNLRTIYEHLMRHSPEPLSAYQEDCLRLHVHGIFTQNFLREEFPEGYIIGEDAYIVAQSLELLGVNEEIVHEVLKAFDSGKFQLTEDWNPLEAPPNGPNYDTVQSEEQVEDMAPRDALQALRNPAGDDDVESEVSFGNNEDDAEGSQNMLDLLYHIAGEQARREGFIHRGVECNNCGTHPIQGIRYHCANCFDFDLCESCEAGSAHTSSHVFFKIRIPAPSRGDIKQVMPPWYPGDPNAFPTSLPKNVSKPLLEQTKMDRTEMDALYEQFKCLAGRFWPADPTGLGYAIDRKGFDSYFIPSSAERPSAANLIYDRIFAFYDTDHNELIGFDEYIQGLARLQKKSRYARLERIFEGYDLDADGYVDRKDFLRMFRAYYALSKELSREMFNAQKDYGLNEEEEHEVVHGSRPISAAFGGSTLNGHASRAGQDKERRPTGDLELANGSSGVLQLESGMQGDRFRAIGNLAIGNRTRSHPFRSFRSNQPEDEPVMLLPGDENFIRSGMEDVDETSEAELTGPDPPLQTYSWPPPLTPTVEDIITALGHEVALEEITDPIDRTRVIYAQSERLDDEADRTEQVRRAEAVRDRWRRRQFYLDEEEGMSKPPGYAEPDSSDEEGLPSALKKSSGEGSASPRRPSVRSRSSSKVRFDDSAIDTDYETRSNASSRSIPVNERWGGYELGQAEADIGKDILYQAVQQGFNELLDPLFKEKEDEWLEVIRTRANRHEFKKERDEYKKALLAADARLDEALQEADQLRTEELFKEATAARPDEDKNDTTRPESSVVPEMHTTAVHDPDDHIELMFGNRLPKPHRTPNDSDQESRSEVSYHDPTLPQFRPSFEGRQSSPAVKPRINPLAGDPVRARALYDLWRRHDEIDAEADERGGPAKLSFEELRRKMVPEDAIGNALGAKGKSTGDEDPEGWESSADLGRLAFIGTWLEMASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFS2</accession>
    <name>A0A0D2BFS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238074.1">
        <property type="nucleotide sequence ID" value="XM_016379397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFS2"/>
    <dbReference type="STRING" id="91928.A0A0D2BFS2"/>
    <dbReference type="GeneID" id="27332136"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05053"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_14_1"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="615" mass="68015" checksum="5333391C6E017417" modified="2015-04-29" version="1">MGRWRGRLYATDRARDFDHERDRHVRVRQIYETIDRQGFQWVVVLVAGVGFLLDGFSLFAGNVALPMIAYVYWHDEVSSFRLTCINIATLAGTLLGQVAFGYLADRNGRKKMYGIELVLLIGSTLGVVMSSRGYNGSMSIYSWLIWWRLMVGIGVGADYPLSAVITAEFAPTKHRARMMATVFFMQPLGQIAGNLISLIVVVISKSSNAEDTVRSVDQMWRWIIGLGVVPGVIALLFRFAIPETPRFLLDIEDDPVKAEFDATQLFGGTAMDTELESNMWCDSIADIEESNLSSHRSVDEHSEGSPSWGITQAPRATLNSSWHLSKADIKQYFWVEGNWKTLAATAMCWLLLDFGYYGIGLSSPQFLAKTWGSLNTSGPRPPWQTNDSPDANIYDMFLDSSVHALVILNSGSFVGGLLMIAAAGRLNRVSLQKYGFLVLAALFIALGTVFITIHQEGALAITLYVVGQIAFNFGPNSTTYIIPAELFPTRYRATCHGISAAAGKLGSILVQVFSAYYKFGSTSPGDDQTKRYGTILVIFSVCMFLGAIITHFWIPDVQQKQNPAKVKRTCPSSVLDLRAVTRTRPSKPLEELALGKWGARSMSVVRSQPVRDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGF3</accession>
    <name>A0A0D2BGF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237936.1">
        <property type="nucleotide sequence ID" value="XM_016379259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGF3"/>
    <dbReference type="GeneID" id="27331998"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04915"/>
    <dbReference type="HOGENOM" id="CLU_1686590_0_0_1"/>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="154" mass="16671" checksum="10E67528CA7332AF" modified="2015-04-29" version="1">MAATNSKLPTLPGGYNYPPPTVPPRAGAPYLESSTLPENFVFIVVGAVLGFVGFLIIAWRVVMSWSINRAFKRDAKSGAAGGNVSYTPLPDLKKNPAAQSGHDMQDLSKLPRSFSNVPSLFFSPTAEVAKQSQRPPSQHLPAGHYRDASDTFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGL2</accession>
    <name>A0A0D2BGL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_02421</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238349.1">
        <property type="nucleotide sequence ID" value="XM_016376779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGL2"/>
    <dbReference type="GeneID" id="27329504"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02421"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW18133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="530" mass="57902" checksum="FB1BC9A25F77FC87" modified="2015-04-29" version="1">MWTLGLKPADVPGSPLPAILIGLFVSFGGVLFGYDTGIIGGILAMKKWRELFSTGYINPTDHLPDVNTAEQSEIVSILSAGTFFGAIFSAPAADYLGRRWAMILNSCVFAFGVVLQVASTSIPLFSAGRFFAGGGVGLLSATIPLYQSETAPKWIRGTLVGCYQLSITVGLFLAAIVNNATKNRDDTGCYRIPVAVQFLFAIILIVGMLLLPETPRYLIKIGKPNDAAKALSRLRRLPEDHPSIQEEVAEIRANHEFELSLGQASYLSCIKKPIRKRLLTGIFLQALQQLTGVNFIFYYGTSYFSNSGLENPFTVSVITSVVNICSTLPGLWLVEKWGRRRLLLFGAVGMATSQMIVASVGTALPDNLAANKALIAFVCIYIFFFACSWGPSAWVITGEIFPLKARAKGLSMTTASNWLLNWAIAYSTPFLVNSGPGNADLGSKVFFIWGGFCCLCAVFVYFSVYETKGLSLEEVDELYTDVKYAWRSQHYQPSSTFVQMQEDVQRKASVLITEGETKSVVDSSVHIESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGP1</accession>
    <name>A0A0D2BGP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Far11/STRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238384.1">
        <property type="nucleotide sequence ID" value="XM_016376814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGP1"/>
    <dbReference type="STRING" id="91928.A0A0D2BGP1"/>
    <dbReference type="GeneID" id="27329539"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02456"/>
    <dbReference type="HOGENOM" id="CLU_003184_0_0_1"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="107"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="537"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="974"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1101" mass="123783" checksum="AA80702EF4F4EB78" modified="2015-04-29" version="1">MASDQPSQELSQGQHLFVRADEVDSGTTILSPGKELPLSALSPSDPTPVGRRPKAPPRPGLRREDSAPPPPPPSQPPPAPPTQTDPTDSLSLPQLRQLVSQFPKIEQQAYAFQYSDAEDYEPEVDEWFHYTELEQDRDYLLVSRESFEQRWKQFSQEHDLSDDLTWITVSPDDRQLFLSEIRKDLAQTSYDDRLDALCCIFYILTGVWSVTSGLEPKRPARENEDSPKLEDDRPNLVQVQWMHKGADEIQQSGIIPDIYACLINAAKAPDYHRVQQDDADDLGDGAFGEAEYRELSLCLSPFYLLVESARVRINGDAGKAIRRSIASLEPSFLVFLTSIISRLRWDESYNIPLMHALQLFWKSILVLFGDLKEHLGRIKSILQPRVDPFSADAAHPVLTASPLDYHQFRQEITSKYPSYNPPLPLIPLETEQKTMLPPLPPQSRADSVAQAYSQPGNATRGSIFHQPVHIATPAPSPPPSPVGPGGKAGKKQNYQTNQNFPFLYPPLDSSSNSIGGKGSTEMQDLMVGKQWEGSDIPLSIIEAGELFASRMRMTRAMRQLWKERDLFMKYERGWRADKFGSTDESSEDAQEENELDSLDPDLRARMEAVEEFFQQALPDLQSLVIVMMKVMLTNVQDIAVRNGGIQDTSQTGGLSRSKSNSNMAQTQGLPMPPPPPRPAEMTLEDLDNVRSREISQKAVSGAIFLLLKWLKASHILKFEYMTQLLLDSNYIQLTLKYFAHQNLEDLVAFKYDRDDLSVWHYCHAHSDHPPLSPTSPGERSETSSIDEAEPPPIPRQRKSPIPNPDGQFREPDPSQGLDAPNRPSVDELGNPLGPVPSQPITTYSFRQFQTAIHLLRILQKLTRGKSHRILFLVTFKSSQILRRVLRVPDPTLRLYVLKLFKSQVPYCGRKWRQSNMRVITAIYLHCRPELRDEWLAGMHDASVEGEVDEAVPLEWALRGLTFWWQRRRYPGVMRKGKQGTVPNGRGKTKDHEDDDDVGEDEDEYEGGQGIDDEERDFFRRELDAIGWGLAGVRIGDGTEDVAFGEEAIGVNGGTNYVSTNGAGGSMGLDQSGVQQTQGPVPAAQPQWITPDATSIENWQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHL8</accession>
    <name>A0A0D2BHL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238321.1">
        <property type="nucleotide sequence ID" value="XM_016376751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHL8"/>
    <dbReference type="STRING" id="91928.A0A0D2BHL8"/>
    <dbReference type="GeneID" id="27329475"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02392"/>
    <dbReference type="HOGENOM" id="CLU_002027_1_1_1"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000036">
        <property type="entry name" value="Inositol polyphosphate phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="870"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1257" mass="139682" checksum="3807815D600E2A17" modified="2015-04-29" version="1">MAEPTYKGTDAAPIKPVSSLRSHFEGLKVNLAPHDDRGSTPSSPQPLRPVDGQSPVPMIRKSFDMVRPTSPWATGANIDRQGSATPSRGDESPPRPVYKRPMSMLVQSSPQLTPSVKVDSPRSPPRTFFERSVSRSPERVDNTPFGKVRELISQHSSRNSSRPPSPRASSPEHQEVLNAGSREQKGADRPLSKSPGRAPPVNRADKPKVPAKPNIIPVPVEPPPGNALNPEARKPSFEARVSPFSTPPSSDESSPSRTPDLNIPTAAFRPVAAASTAGRNAGPPLPEPVERPRDARIMGFASKTPAADRKDPRTLGFGYSESQSHPVQAPTGLPSRANTVSEKPSRDPRDFGFVAKPAPRHVSETIRASPSPPVHSLPPVRAPPSRDARQFGFSSRPQSEVDTIEEEQRPGLPPRRNIEPPPRPSNESKNPPRSTATPSQTTTPDRFKKPFPTQQLSRAPTAPVDMRFPPPPKRGSVDSVEPSISASPLRSQMLNGTSPSRPGGRVYGSDSDEAEGHVEEPLTIRSEYPDATHTNRRPPYCKGAVWEIATKSDARTMEVCGQHLCTTGYTTRVFDMTSGEQIMSISHGETVKVTALAFKPATDLSGEGAKIWLGTITGELMEVEIATYTIKITNSDHNRREIVRILRSRGDLWTLDDDGKLFVWKADETGIPNMKYSHISHKVQKGHTFSMAIDGLLWLATGKEIRVYEPGDEMTFTALTKPLSQHGTGDVTCGTHSTEAGGRAYFGHNDGRVTIYSTRDFSFIGNVKASDYKINSMSFVGDKLWAAFKTGMVYVYDTSTSPWKVNKDWRAHNGPAHELLLDPRSVWTLQRLQVVTIGHDNFVRLWDAALEEDWIESEMQKRDVEYCTFREIRAAVVTWNVGASSPYYLKKDFIADAIHAEDPPEILVFGFQEVVDLEDRAVTAKSILGFGKKKDTVKNEQYQSRVYREWRDHLTSAISRYTGAHYAYSELHTSSLIGLFQCVFIRQEERKNVRNLQAASVKLGLKGRYGNKGALITRFTMDDSSVCFINCHLAAGQTHTSHRNNDVATILEAEALDPEADPDCRSSLYVGGGDGSQILDHEICILNGDLNYRIDTIPRDTVISMVKRNELAKLLERDQIMVSRRRVSGFRLSQFTELPITFAPTYKYDVGTDNYDTSEKKRAPAWCDRLLYRGPGRVKQIEYRRHEVHASDHRPVSGVFKLRLKTIDARKRARVKEDCLNKFVDIRRRMAEKESIEYLVSTLGVAEAEAKRLITAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHZ7</accession>
    <name>A0A0D2BHZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor CLF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor clf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_02846</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238774.1">
        <property type="nucleotide sequence ID" value="XM_016377204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHZ7"/>
    <dbReference type="STRING" id="91928.A0A0D2BHZ7"/>
    <dbReference type="GeneID" id="27329929"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02846"/>
    <dbReference type="HOGENOM" id="CLU_011554_1_0_1"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000269">
        <property type="entry name" value="Crooked neck pre-mRNA-splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="13">
        <location>
            <begin position="225"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="13">
        <location>
            <begin position="367"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW18558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="675" mass="81139" checksum="25A27FFBEAD576F6" modified="2015-04-29" version="1">MDSSRGPPRVKNKAAAPVQISAEQLLREAVDRQEPGLQAPTQRFADLEELHEFQGRKRKEFEDYVRRNRINMNSWMRYAQWELEQKEFRRARSIFERALDVDSTNVQLWIRYIEAEMKTRNINHARNLLDRAVTILPRIDKLWYKYVYMEETLGNVPGTRQVFERWMSWEPDETAWLAYIKLEKRYGEYDRARAIFERFTVVHPEPRNWIRWAKFEEENGTSQLVRDVFGVAIESLGDDFMDEKLFIAYARYEAKLKEYERARAIYKYALDRLPRSQSVALHKAYTQFEKQFGNREGVEDVILAKRRVQYEEQLKTNPRNYDVWFDLAKLEEAGGDVDRIRDVYERAIAQIPPSQEKRHWRRYIYLWIFYALWEEMTNKDVERARQVYQECLKLIPHKKWTFAKIWLMKAQFEIRQMQLQAARKTLGQAIGMCPKDSLFRGYIELEKQLFEFVRCRTLFEKQIEWNPSNGQSWIQFAELERGLDDLERARAIFELAIDQPTLDMPELVWKAYIDFEEYEEQYDRARALYERLLSKTDHVKVWINYARFEINVPDPNEPEVEGEEQKVSEDAKARARKIFERAHDLFKSKSMKEERVDLLNAWRSFEQTHGSPEDIEKIEKQMPRKVKKRRKIEEDRFEEYIDYVFPADDESAAKMSKLLAMAHQWKAKQTNGSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BI39</accession>
    <name>A0A0D2BI39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="1">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_02912</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="1"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238839.1">
        <property type="nucleotide sequence ID" value="XM_016377269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BI39"/>
    <dbReference type="STRING" id="91928.A0A0D2BI39"/>
    <dbReference type="GeneID" id="27329995"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02912"/>
    <dbReference type="HOGENOM" id="CLU_014658_2_2_1"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="5 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="378"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW18623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="586" mass="65830" checksum="7CFE15EC0841C0F4" modified="2015-04-29" version="1">MCGIFACHGHPSIATFKTTALQCVKCLRHRGPDWSGNWIGNNTILCHERLSIVGVDTGAQPLVNDEGSIALAVNGEIYNHRILRKHLQEPYNFKTHSDCEVIIPLYMQYGIDAPKHLDGMFSFVLYDKTQDRTIAARDPIGITSFYLGRSSTTPGAVFFASELKALAPVCDSIESFPPGHVYDSKTDKLTRYFEPSWWDPEKVPSTPVDYKLLRKTLEKSVLKRLMAEVPYGVLLSGGLDSSLVASIAQRESLRQRELISSQTNGASSEINGDTPQTGAKLVGIDDEDELSTVTFLPQLHSFSIGLPGAPDTKAALEVAKFLGTKHHDFTFTIQEGLDALSDVIYHLETYDVTTIRASTPMYLLSRKIKAMGVKMVLSGEGSDEIFGGYLYFHAAPNREEFHRETVRRVKNLHLADCLRANKSTSAWGLEARVPFLDKQFLEVAMNIDPADKMITKDRIEKYIIRKAFDTTDEPETKPYLPDNILWRQKEQFSDGVGYGWIDALKDNAELNVTDEMMKNPKAEWGDDIPDSKEAYWYRTMFDQHFPPYCASTVMRWTPTWSKQTDPSGRAIATHVARYENGEVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BI92</accession>
    <name>A0A0D2BI92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_10368</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231285.1">
        <property type="nucleotide sequence ID" value="XM_016384683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BI92"/>
    <dbReference type="STRING" id="91928.A0A0D2BI92"/>
    <dbReference type="GeneID" id="27337451"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10368"/>
    <dbReference type="HOGENOM" id="CLU_012062_37_0_1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8 11" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="13">
        <location>
            <begin position="12"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW11069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="371" mass="41037" checksum="27ACA62CA7F88F92" modified="2015-04-29" version="1">MAESKSGRPRVYFDITIGGRQEGRIVFELFNDVVPKTAENFRALCTGEKGEGKSGKPLSYKGSIFHRVIKSFMIQGGDFTAFNGTGGESIYGEKFPDENFELKHDRPFLLSMANSGPGTNGSQFFVTTVPTPHLDGKHVVFGEVINGKNIVRKIENLPTQSDKPVSDVVVADCGQLEGSDYSTATQKAPDATGDPYEDFPDDQGELKGEEYYKIALDLKEYGNKAFKAGDIETGIEKYQKGLRYLNEYPAANENDPKDLQANMDSLRFTLHSNSALLAIKAKRYAEAQKWAGFAIDAIPKDAKDTDKAKAYFRRGQARVALKDADEALKDFEQAAKLAPEDAAIKSELAKTKKSLQESLKKEKDAYKKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BID5</accession>
    <name>A0A0D2BID5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238934.1">
        <property type="nucleotide sequence ID" value="XM_016377364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BID5"/>
    <dbReference type="GeneID" id="27330090"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03007"/>
    <dbReference type="HOGENOM" id="CLU_063290_0_0_1"/>
    <dbReference type="OrthoDB" id="2290255at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="163"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="321" mass="32666" checksum="FD490D61253B5228" modified="2015-04-29" version="1">MSYNDDRREYGGGGRDGDNYYDQSQRYDDGPQRGEGYGRDSGRDSYGQQQGGYGDSEPPRHHRRENEGGYGGGGDRYDQGGYGGGRSDNYGSSGGGRDRYDEGGYGGGGGGGGGGGGGGGGNYGNSGSGGGDRYDEGRHGSGNYGGSGGGYGGGAGGGNADFDEDEIVRHNQRHGNSEDEGLFSQALGFLNNHKQSAQSEDLDEGRIQQSHQQLYQQGGGGQQHDASSLGAGAAMQALKMFSGGGSGGGSGGSQSQMIAMAMQEASKLFDQQSSQGNVSGGTDKQSVVNSAAKYALQMYMKSQGGGSGGASGLMSLASKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIZ1</accession>
    <name>A0A0D2BIZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PV08_02808</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238736.1">
        <property type="nucleotide sequence ID" value="XM_016377166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIZ1"/>
    <dbReference type="STRING" id="91928.A0A0D2BIZ1"/>
    <dbReference type="GeneID" id="27329891"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02808"/>
    <dbReference type="HOGENOM" id="CLU_082461_0_0_1"/>
    <dbReference type="OrthoDB" id="4121174at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249868" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="18"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KIW18520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="203" mass="19833" checksum="4167AB082C2955CE" modified="2015-04-29" version="1">MRYVVYIVALVTKLALAIPQVDSSQLSALPPCARDAAAAALGSSGCALSDTTCICNSKAFQDAITTTILQSCSAGDVQAAVAFGQTICGNALGAAAPTTSDSSYTAPTSDADAGAVSTTTVPTTETSTTSVPVDTASAPITTSVSTVPTTMATMWNTSCTTTGTVPTAPGSAPSTYTGAAVETKLGQGILAVLVGVAGAVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJS3</accession>
    <name>A0A0D2BJS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239384.1">
        <property type="nucleotide sequence ID" value="XM_016377814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJS3"/>
    <dbReference type="STRING" id="91928.A0A0D2BJS3"/>
    <dbReference type="GeneID" id="27330544"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03461"/>
    <dbReference type="HOGENOM" id="CLU_017779_3_1_1"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF116">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="173"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="599" mass="65480" checksum="A896B7D2076A081C" modified="2015-04-29" version="1">MLRVGRPAASVLRCVEPQSQCRNSVLQRVPAAKLFHSSTRTSDKQEDASRSFRGQLYESTADRLKRERQEQAEYIKASSERKGEPRALALSVVILSVAGGAYWLGSRGEKALDTTSTTPLSRAQPPQHDTRDSVLQAAWVDFAQIVGKENVSTTPDDLLSHSGSEWSSYTTKPNEKPFAIVYPATTEEVSQIMKVCHKRRIPVTALSGGTSLEGHFAPTRGGICIDMSRMDKILQFHPKDLDIVVQPALGWEDLNEYLGDSGMFFPPDPGPGAKIGGMVGTGCSGTNAYRYGTMRDWVVSLTVVLADGTIIKTRRRPRKSSAGYNLTQLFIGSEGTLGIVTEATLKVTVLPKKQSVAVATFPTIHAAAECVAKVVGEGILLAGMEILDDVQMRCINKSGMTSKKWQEAPTLFFKFAGSPDGVKEQINIVRNLAKGSQNKSFEFAKNDEEAAELWSARKEALWSVIAIKENPSDHVWTTDVAVPISRLADIIQETHDDVAKSGLIGGICGHVGDGNFHTILLYSDSQKQIASDVVHRMIQRAIEMDGTVTGEHGVGLKKRDYIREELGEDTVDAMRKLKQAYDPLGILNCDKIVQLEAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJY1</accession>
    <name>A0A0D2BJY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239444.1">
        <property type="nucleotide sequence ID" value="XM_016377874.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BJY1"/>
    <dbReference type="GeneID" id="27330605"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03522"/>
    <dbReference type="HOGENOM" id="CLU_001136_0_2_1"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="164"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1274"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="895"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="940"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="945"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1434" mass="159722" checksum="E63FA2E1F6E6F1D0" modified="2015-04-29" version="1">MASQPSQAHVGLGFDVPYRTRPATQEYNHHLSRGLGGDVARYSTASAHQTPGQIHGSTSHQPNGASPRIIPEAEDYLSSRPAPLHRTKSDLGPRARGGMASPPSEDKLAHIRHGWDDEYTSNEYLSLLHSTFYMYYTEKRHESNGSPSEESKQYPSVDWRMKDRMKTVSAALAICLNIGVDPPDVIKTNPTAKLEAWVDPTGSSSGSTKTMEQIGKRLQEQYESLSLRTRYKQYLDPSIDETKRFCISLRRNAKDERVLFHYNGHGVPLPTASGEIWVFNKNYTQYIPVGIYDLQSWLGGPSLFVYDVSHAGNIVANFDTFLAKHEKENEEARKKDPNAALQNYGDCIQLAACGKAEMLPTNPDLPADLFTCCLTTPIDIALRWFVLQNPLPNGHSLEDGKIPVPGRLQDRRSPLGELNWIFTAITDTIAWNILPRPLFKKLFRQDLMVAALFRNFLLSERIMRANHCHPISSPPLPETHHHPLWQSWDLAMEMVLSQLPLLREAEEGKRVYEYQHSTFFSEQLTAFEVYLSSGPTKDHAPDQLPIVLQVLLSQVHRLRALILLSKFLDLGPWAVHLALSIGIFPYVVKLLQAASLELKPVMVFIWARIMAVDYTVQSDLLKDNGIHYFISIMNPRSDIPVGNASEHRAMCAFIVATFCKRYPPGQTVCLLPELFEACLLNMAEPENPLLRQWSCLCLSMLWSDYADAKWMGIRSMAHARLCELSLDPVPEVRASMLHALTNFIGIPDLTDQVSQIEEGVASSVLFMTSDGSTLVRKELVVFLSAFVKRYENKFLVVAYESLVEERDRHPYWGNDASAVEPNASLMPISANSIYGCVWLQILILSIDPHPEIARNAAIVVDYIHDTLINHSPLAQLALRVIDDLLRANKREETQLKKVPSMASLRQVESRPGTPPPQMQKQTSYLSLSLKRAGTSLRNLAFGASEPSTPSKENSPQTSPSKTRDSVHPINTPRGRLPPEWSRAPETADAHGAVGPYQSAILPTSAGFVPLDAKQKGRLPLTSTLLEWSTEYFREPQMRPNDPDEPGSADYNSRLWRRNRNEKIIADSQPLKGVAGSSKWTRLEGFLNNQNQPMRLAFHQFDDHLAVTDDKDTVTIWDFQRNEQVSRFSNGNPTGSRINDAKFLNEDDQPLLMVGSSDGVLKVYRNYHSSSEVKVITAFRALTELIPSNKNAGLVFDWQQGQGKALVAGDVKVIKVWNAATELCVGDIPARSSSCVTSLTSDQVAGQIFIAGFGDGVVRVFDQRLNPRTAMVKIWREHQQWITNIHMQRGGVRELISGSRNGEVKLWDLRSDKAVLTLAATSNKVHDGHLAAATTAAGGPGGVVAHGPLLRSLSVHEHAPVFAVGTDRHEIRTYNTNGDALGVFEPLPRRLERVVGGSLAGRGTQSPIVATAYHPHRMLLACAALGDGHVSLMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKP3</accession>
    <name>A0A0D2BKP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239371.1">
        <property type="nucleotide sequence ID" value="XM_016377801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKP3"/>
    <dbReference type="GeneID" id="27330531"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03448"/>
    <dbReference type="HOGENOM" id="CLU_041442_0_0_1"/>
    <dbReference type="OrthoDB" id="5394557at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="478" mass="52064" checksum="4D6BA4680DD3400C" modified="2015-04-29" version="1">MISTRPLYNSNLEFFRRSDRGDHMPLSQIHHIQDYHEGPGHLSNRTTPSSEPDNRSTGGQRKRVPVACERCRKRKIKCSGNEGDNQSCANCKNAGHGDSCRFLRVSSADVGTFGPRGWHSPLRYSPYSVPSTHRHSYVPSSSRYTSQNSVTYPTVHSNIDFAPYGATTPTADWTKAPYVGTYSPYPDDEETSPYTSYPPPYILPNTDPMSSASSYYVHTQNVRPHPGTLWSEQQSCLSQQNSSLSNPTFTVIPETQQSYAATAGFGNLPSDRILPTPFSARGTSSTHASSLDSVPNSASTQRSSMYWSPDSVASTQHIPSQVDSDADQEQLDDRRNASYSLNDMSYSHVALGDSLSTGILPVGLSLPADAPHTPPTVTSAEGLQAHQSLVQRSRESPKSHLDNTPATYGYTALMTGRSSQMRSTSTQLSNGSVYCHSHPLLTRREALLDGCNPADSSGCPVNPTRNPTTGISNVTSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL11</accession>
    <name>A0A0D2BL11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239506.1">
        <property type="nucleotide sequence ID" value="XM_016377936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL11"/>
    <dbReference type="STRING" id="91928.A0A0D2BL11"/>
    <dbReference type="GeneID" id="27330667"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03584"/>
    <dbReference type="HOGENOM" id="CLU_006197_0_0_1"/>
    <dbReference type="OrthoDB" id="3989227at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF79">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="994"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1112" mass="123814" checksum="FB08ADC5B99EF71A" modified="2015-04-29" version="1">MFHFSGRGHEPSSDSTMPASRNQGSSGEKRQITRSRISYSCQTCRKRKVKCDKVHPVCGGCKKANEDCVYNEDTKPPIAALTETSDGSKKRRTTYERQTSTSNSSSSPPQDKSMPPPPQLKAIEEQLRRLTSMVDALRNSSSNDSDLRDLLTPVHSQSEHESDDASSRPDLSIGMFRSRNSGSPKDVNELNWPLSGLKLTNGNPKRAEDPFWIHISDELDQLNHMMRRANNCNVPTGVQNKQGDGPKPPASGLHASSIKDDFWEPMSFEKAAAVSRIDAYNPDSDCTMCQTVPFSKATLLHTIPIHCSHTTAYHHLFKAFPTRAQSNVLLRCWLSTVYPILPLHIPSDVLEKHEKLWNQIETAGLAQMQTQYPDLELYTIMYVIWYAGVLSLSRKGLQRWFPGLTRAELATKFHGGAVFTLRMGHFMRDVSLHKLAALVLMQSLPIAEEDPVQASLYTQLSVRLGLTMGLHREPTLFDLPVAEEGMRRRIWWQLVLLDTSLVISTGYPTLISENVSDTRINCEDKDAFAADDDEGISLEGGKKTKPFSWGEAHSTDENGNLTLHRTMCLVARAKSVHACALRAIIDTHLSTKTITHTDMQKLKRVMAETEEQINGIIAQIPAQGLPEMGFVPEGPNGKARQAYSLDCDSAMSSSVTDKDLAFYQNYVSDDKLATPLARYHRRKLAVFNKWARITLSMLNDKLHCVAYAPFLKNAKSKMWTVARQCALHVCHSFMRKFISLVEDPDLETFRWTWPAMYGPLHAGLIMLVDLFEKPDSVEAPRSRELIDKVFSLSDPQTGIVGGPNGVTIQRPLREGGVEPWDMLRGLRSAAWQRAGLDPNVLWTQEDQLKVGVATPLTDAQRIAQSLREDTVYENGNGQATLVNADEGNRTTDHGVRYMVKLAASEINGEEEPEGYPCSRALRNRFLRDIESGDRQARGLKLVRLEGQQKMPFPLSGFAEQCSQQAAQGHIPGSCSGIGNPVIRPTALGYHQCSTGLASSDKREDDGPTPTVQQDGHHNSHSDTRLPPIGEDTPQKSLLGEPTGHGLSAPVMQSSHGNHENEQTFNAHQETQNDVSVSSNADFGFDWARWDSVFGQYTGFTDMMEDVTLSWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL44</accession>
    <name>A0A0D2BL44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_09212</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232155.1">
        <property type="nucleotide sequence ID" value="XM_016383532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL44"/>
    <dbReference type="STRING" id="91928.A0A0D2BL44"/>
    <dbReference type="GeneID" id="27336295"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09212"/>
    <dbReference type="HOGENOM" id="CLU_006587_4_1_1"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA-binding" evidence="19">
        <location>
            <begin position="55"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW11939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="675" mass="73813" checksum="45EA62686FDDAD34" modified="2015-04-29" version="1">MPSASGPAPISNGLPKVNIPDGNNSPGSETPFSANDNIRRFDPPSRVLSPVQHALFHNKTRCFVYGMQPKAVQGMLDFDFICKRTTPSVAGIIYTFGGQFVSKMYWGTSETLLPVYQSVDKAFEKHPDVDTIVNFASSRSVYSSTMELMNIPQVRTIAIIAEGVPERRAREIMIKSKEKGITIIGPATVGGIKPGAFKIGNTGGMMDNIVASKLYRKGSVGYVSKSGGMSNELNNIISQNTDGVYEGVAIGGDRYPGTTFIDHLIRYQNEPECKILVLLGEVGGVEEYRVIEAVKKGQITKPIVAWAIGTCASMFKTEVQFGHAGASANSQLETAVVKNQSMKEAGFFVPDTFEEMPQVLAEVYQKLVKEGTIKPAPEPVPPKIPIDYAWAQELGLIRKPAAFISTISDDRGQELLYAGMPISDVFKEDIGIGGVMSLLWFRRRFPPFASKFLEMVLMLTADHGPAVSGAMNTIITTRAGKDLISSLVAGLLTIGSRFGGALDGAAEEFSKAFDKGWSPREFVDTMRKENKLIPGIGHRIKSRNNPDLRVELVKEYVLKHFPSHKLLDYAIAVETVTTSKKDNLILNVDGCIAVCFVDLMRSSGIFSSEEAEDYMRMGVLNGLFVLGRSIGLIAHYLDQKRLRTGLYRHPWDDITYLLPTLAKGGSGEGRVEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL78</accession>
    <name>A0A0D2BL78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Golgi apparatus membrane protein tvp15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232175.1">
        <property type="nucleotide sequence ID" value="XM_016383552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL78"/>
    <dbReference type="GeneID" id="27336316"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09233"/>
    <dbReference type="HOGENOM" id="CLU_120579_0_0_1"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW11959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14427" checksum="2C3BD427B48EDA7F" modified="2015-04-29" version="1">MDFSNIFRLVNLAVGGIMVLGGISQFIPDIGFRNIIVGIYVIIFGLAVAGLELLPQVPPYLPKYASFLFSFLGRGIFYIFVGCIILENHVLRIIAGTLIGFVGVGYCALEFLPSIEPPSNMRDADAGWGAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLC4</accession>
    <name>A0A0D2BLC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239969.1">
        <property type="nucleotide sequence ID" value="XM_016374693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLC4"/>
    <dbReference type="STRING" id="91928.A0A0D2BLC4"/>
    <dbReference type="GeneID" id="27327410"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00327"/>
    <dbReference type="HOGENOM" id="CLU_041441_2_0_1"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="323" mass="35898" checksum="3D3A5D5F4AA88394" modified="2015-04-29" version="1">MAATIPTRLLILSDTHGVDFSPEDRPQQYADVAIHCGDLSDGSELDEFRTAIQTLKSINAPLKLVIAGNHDFTMDIAAFQGKLAEAATPLEPELVAREYGTPGQARQLFEDAKNDGIVFLDEGTHHFALQNGAKLKVYASPYTPALGAWGFQYHPDKGRQFDIQEETDIVITHGPPKGIMDFTHGRERAGCPNLFTAVAHARPLIHCFGHIHEGWGARLVTWKDSGFDKPSHFTSIDNGNSPVIGKLAALRPNRFDSEEIAEEKQERLRELARNKCAVTSHRNQDQDPLEAGKETLFINAAIKGEEEFVQRPWLVDIELRKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM63</accession>
    <name>A0A0D2BM63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239906.1">
        <property type="nucleotide sequence ID" value="XM_016374630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM63"/>
    <dbReference type="STRING" id="91928.A0A0D2BM63"/>
    <dbReference type="GeneID" id="27327347"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00264"/>
    <dbReference type="HOGENOM" id="CLU_018986_2_3_1"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000043">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="440" mass="46944" checksum="3B6F0FE154001C92" modified="2015-04-29" version="1">MTITASPRPLRPNERILTSEDGAIHTPARAPSPVHQFGTLAVHAGSPHDPSTGAVIEPLSLSTTFAQTAVGKPVGQYEYSRSANPNRDNFEEAVAALEHARYALAFASGSATTATILQSLASGSHVISVSDVYGGTHRYFTKVALAHGVEVTFSPSIELDVEELIRDQQTKLIWIESPSNPTLSLVDIRHVATVAHRHGILVVVDNTFLSPYVQNPLDHGADIVVHSVTKYINGHSDVVMGVAAFNSDELKERLTFLQNAIGAVPSPFDCWLAHRGLKTLHLRAREASKNALAVARALEASPNVIAVNYPGLDSHGQRAIALKQHRDGMGGGMLSFRLKGGHPAAERFCQQTRIFTLAESLGGVESLCEVPSAMTHAGIPKDQREAIGVFDDLVRLSCGIEDADDLTKDVLQALEKAVVGPKISNGVNGATATGSGIPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMJ2</accession>
    <name>A0A0D2BMJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240369.1">
        <property type="nucleotide sequence ID" value="XM_016375093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMJ2"/>
    <dbReference type="GeneID" id="27327811"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00728"/>
    <dbReference type="HOGENOM" id="CLU_176431_0_0_1"/>
    <dbReference type="OrthoDB" id="4120262at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="106" mass="11444" checksum="D06F0F6420E00079" modified="2015-04-29" version="1">MPPMRLPVTTLGQTVRTFASHSARRTLAHRLPGLHGPSARILAKTARPHHMPASSFPMVVRDGLSYSALGALTSAGAFLIYCAQYLLVPVFFAPLPIPSRGVDRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPF2</accession>
    <name>A0A0D2BPF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite efflux pump SSU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_08146</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump also represents a detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233175.1">
        <property type="nucleotide sequence ID" value="XM_016382472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPF2"/>
    <dbReference type="STRING" id="91928.A0A0D2BPF2"/>
    <dbReference type="GeneID" id="27335229"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08146"/>
    <dbReference type="HOGENOM" id="CLU_030057_6_1_1"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000004">
        <property type="entry name" value="Malic acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW12959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="448" mass="49962" checksum="2807A66A9ABD230B" modified="2015-04-29" version="1">MDPSGTYANCQISRTRSFHHECQDGVVQTGKDQLESSFSAVNSHGWRRVVLNFTPSWFAATMGTGIASILLHNLPYNGDWLYWLSVVVFCLNVALFCTFLFISVLRYTLFPGLFMAMIRHPVQSLFVGTFPMGLATIVNMIVFVCVPAWGEWATTLAWTLWWIDVVISVASCMWLPFVIMHIHESELSKMTAVWLLPIVATIVAAASGGIVAEVLPNPQHQVWTIVTSYVLWGTGFPLAMVVLVMYFHRLTIHRLPPREVIVSVFLPLGPLGQGSFGLMQLGKVCAAVFPKTENLGGPEGGRVIYSASIVCALVIWGYGCVWLFFALASITRSKFPFNMGWWGFTFPIGVFAVSTCTLAKEIPSLFFKVLGTIFSIAVVLLWLVVATVTCKSAIAGTIFFAPCVQQYEQEIVRERKRKGKESGRPWYKIRSVNKDQENEESKDAKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR95</accession>
    <name>A0A0D2BR95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02123</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241759.1">
        <property type="nucleotide sequence ID" value="XM_016376483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR95"/>
    <dbReference type="STRING" id="91928.A0A0D2BR95"/>
    <dbReference type="GeneID" id="27329206"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02123"/>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW21543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="218" mass="24470" checksum="3A2556846C13856E" modified="2015-04-29" version="1">MAALTSSWQFLREYKLVVVGGGGVGKSCLTIQLIQSHFVDEYDPTIEDSYRKQCMIDDEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSITSRQSFEEIMTFQQQILRVKDKDYFPIILVGNKCDLEGERAVSREEGAQLANQFGCKFIETSAKSRINVDNAFYDLVREIRRYNREMSGYSGGAPPLGGHGPGQKFEVDNQSDGAGCCSRCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRT4</accession>
    <name>A0A0D2BRT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cyn1</name>
        <name evidence="5" type="ORF">PV08_01695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241331.1">
        <property type="nucleotide sequence ID" value="XM_016376055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRT4"/>
    <dbReference type="STRING" id="91928.A0A0D2BRT4"/>
    <dbReference type="GeneID" id="27328778"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01695"/>
    <dbReference type="HOGENOM" id="CLU_103452_0_0_1"/>
    <dbReference type="OrthoDB" id="10019422at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate lyase C-terminal" evidence="4">
        <location>
            <begin position="87"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW21115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="160" mass="18174" checksum="0AE82F754236DE69" modified="2015-04-29" version="1">MSLATLDVRQHPNLRSSSETLFEAKAKKKVTFEAIAKELGRDEVAVAALFYGQAKASPEDVKKLSEYLELDHATLEAQMTGFPDRGKSVEMPPREPLIYRLYEIVQNYGYAYKAVLNEKFGDGIMSAISFSTHVEKEVDKDGNTWVNIHLRGKWLPFTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRU8</accession>
    <name>A0A0D2BRU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234160.1">
        <property type="nucleotide sequence ID" value="XM_016381058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRU8"/>
    <dbReference type="GeneID" id="27333808"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06725"/>
    <dbReference type="HOGENOM" id="CLU_885764_0_0_1"/>
    <dbReference type="OrthoDB" id="4142835at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="325" mass="37174" checksum="F55CBD3126C6E8C1" modified="2015-04-29" version="1">MCVRTKTTYGCGCEFKTTNECNDPHCSHLERWKFPREGDCKICKEGGQAVTRGREGKGRYAQQLNRRHHQEGREPSCDPVPEDIGGGVSPWAAPLKREKEWHSPSRKMADDAWLQEHAERNSDLQTLRESMSAHSDSDRASTAILSPPSRGRRVYEVEEEDDYCTVDRDADYNHRHRRQPAPRSLQIEIRSVHNDQPRRTSSRHASRHRRRHDSQESFQSVHSGQSSSRRYKPAPTSYTTHDIYETHDSGYGSYGSRTSHHGYEIAKTEPYTYSPAPRVVTIKAPSSSYQTGYGIPPHHGSHPSHPQGINVVTRSPMYTYSSQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVB8</accession>
    <name>A0A0D2BVB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235430.1">
        <property type="nucleotide sequence ID" value="XM_016379603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVB8"/>
    <dbReference type="STRING" id="91928.A0A0D2BVB8"/>
    <dbReference type="GeneID" id="27332342"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05259"/>
    <dbReference type="HOGENOM" id="CLU_006533_2_4_1"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="166"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="656" mass="75494" checksum="9E942FEF442D99BD" modified="2015-04-29" version="1">MAFAAGRICARCSHRLASPRLPPQSQHRAFSQSWSRTAFTPPTPASLGKAVPAKQFKRTRKWIRRLAYLSLFGAAAYVVDKRYYASSLTRCTRTFAAGLTTALDYKINFRENPPFADDIADVHARNATRLFHLLRSNGGLYLKIGQAIAMQSAILPPEFQKMFAKMFDDAPQNDWAEVRQVIMEDFGGKTPEEVFGISFDGDPEAGVMEKKARASASVAQVHWARLKDGREVAIKIQKKEIAQQVGWDLWAFKVVTKIYTWWFDLPLYTLVPYITERLLLECDFQAEAENSKRMAELVKGEPRLRDRVYIPKVYDELTTKRVMTAEWIEGVRLWDKDALTRPWQGGWRTGSPGCHGTPLDPPQTPMTTLQQRSRQHDEELKPDRSYWRGKDGKGGLGLNLKEVMTTMIDLFSAQMFLWGYVHCDPHPGNIFVRRLPNGHSELVLIDHGLYIHMSPKFRHQYSLFWKSLMTFDNQTLKEIVGQWGVNNAEIFASATLMRPYEGGDLTVSKRIKGISEAERRKRHYEMQQAMRKGIKEILGDEEKWPRELIFIGRNMRIVQGNNQFLGSPVNRIKITGNWASRALAEDKNLSFTERWKNFGSHLIFKMVLLATDAYFWYSKLKQVLGRGKGMDDDMEQQMRRMAKDYGIEMNHNVFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BX70</accession>
    <name>A0A0D2BX70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236110.1">
        <property type="nucleotide sequence ID" value="XM_016380283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BX70"/>
    <dbReference type="GeneID" id="27333027"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05944"/>
    <dbReference type="HOGENOM" id="CLU_051062_2_1_1"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF7">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30436" checksum="C7F4CDF4A74AD4C9" modified="2015-04-29" version="1">MAKEAAASLDLEAAATRILTATSRPELTQRSSGSSTQHPFGEDKPIYLSPGVGHGLGSPTALAIGAFATTLTTLSISLMEWRGVTTTNVYIGNFFFVAGIGMLISAQWELVKGNSFAYTVLSAFGGSKALHSTFSAVGYMYTDTQKGLFYAGFGAIITPDFGVLQAYGGDITQYNNALGFWMLLWTVFNTFFLIASAPINVVYLLIFLTVELSFGLVAASYFATADGHHGAGINLKKAGGAFGFASGLLGYYTLGHLMCQEALFFTFPMGDTGRFFRRRLKKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BYB5</accession>
    <name>A0A0D2BYB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236525.1">
        <property type="nucleotide sequence ID" value="XM_016380698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BYB5"/>
    <dbReference type="GeneID" id="27333443"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06360"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="68"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="600" mass="63132" checksum="C7072D8CC72565E3" modified="2015-04-29" version="1">MAIEVASAEADASDQVPTETSPLLGRQNGQVVDPINPQPGSSSENVENGDNATALAAEGPSTKKLVLIMAAIWTGVFFAALDTTIVATLTAPISSSFDSLSLLSWLASGYLIANAACQPLSGKLTDIFSRRYGLVFSNVFFAAGTLICGLAPNAQTIIAGRVIAGIGGGGLSCITTFVTSDLIPLRRRGLWQGYGNLIFGLGMGTGGVFGGLLADRLSWRWAFLLQLPFIVVSTVMVWFLVDIPVNASTKPALRRIDFLGSFLLVTSLVLLLLGLNSGGNQLAWSHPLIVTSLSLAFVTFALFLFVESAPPKSSPESSSSSSSSSSSSSSSSSSPTGRRLRRLLRSAVAEEPVIPVSLIVRTRTVLFSCLANWFGTMASFIALYYVPLYLQARGLSSTQAGLRMIPFAASTSVGSLGSGYLMRLTGRYYGCMAGAMGVFVAGAALLCTFRLDTAAWATYAYVAPLALGYGAMLTVTLVAMISAVDHAHQAVITAASYAFRSTGSTIGITVAAAVFQNVLTGDLEAHFGRLPGSDGHIRRIRDSLDAVKHLPEGWDAHLVYASYMHALRGAFFAGLGLAFLAAVAGLGMKEHVLHKNLARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZT4</accession>
    <name>A0A0D2BZT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_04054</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237080.1">
        <property type="nucleotide sequence ID" value="XM_016378403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZT4"/>
    <dbReference type="STRING" id="91928.A0A0D2BZT4"/>
    <dbReference type="GeneID" id="27331137"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04054"/>
    <dbReference type="HOGENOM" id="CLU_013528_3_1_1"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000186">
        <property type="entry name" value="Putative Cysteinyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="12">
        <location>
            <begin position="31"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="723"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="806"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="723"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="814"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW16864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="832" mass="94504" checksum="227097956853A900" modified="2015-04-29" version="1">MSQPPWNQPTGPTHQPQLKIYNSLTRSKVPFVPLQPEHITWYACGPTVYDDSHLGHARNYVTTDIIRRILRDYFHFKVRFVMNITDVDDKIILRGRQKHLYDAYKKNHRYDEDSNRDETGSDQETRYIDDKVRQDVRQAWHYYVQKNLKRIGPKTLLTPETFDGVVEHFYGDILAGGSLEPGTKPGDKEAKVKMHINTARSTAKALLSDPKMLTPHEFYARVNDPMCLVLDDQFGKSIRGDDYAVFTKLTKEYENRFFQDMHDLNVLDPDDLVRVTEHGKEIADFVKKIADNKMAYRTTDGSVYFDIKAFESAGYPYARLEPWNRNDKELQADGEGALSQKDGTSKRSEADFALWKASKPGEPSWESEWGPGRPGWHIECSAMASGKLGQQMDIHSGGIDLAFPHHDNELAQSEAFWSDGSHRQWVNYFLHMGHLSIQGSKMSKSLKNFTTIREALHVRKEWTPRSLRIIFLLGNWKDGIEITDDMVVEGRNWEDRVDNFFLNAIENIKNAKASNDYKGIMTIPLLDAEEKVRAALLDSFNTPLAMSTISTLINAYNSAKKSDLTAEDHRNTGLFVTKMVNIFGLNGNEPAETETIGWRGIDIPDVAKEYVYPLAKMRDELRQAAIAKAITAEKVQEIVSTSPGLEEPPPSGRPRPSYARALSEFSRSALEVASPAESKDLNKQILALCDRVRDVDLWQLDIYLEDRENAPSLVRPVTEGLKAARREREEKARAKEEAKKKREQEALEKLQKGKLAPSEMFKPPHSEEFSAWDPDGVPTAAKDGSALSASRVKRLKKEWDAQRKAHEKYLAVTQQQQAPPQQNGLAAGGQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C747</accession>
    <name>A0A0D2C747_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239605.1">
        <property type="nucleotide sequence ID" value="XM_016378035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C747"/>
    <dbReference type="GeneID" id="27330767"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03684"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_8_1"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="528" mass="58615" checksum="9FC1A7DE4800F018" modified="2015-04-29" version="1">MQSDKHSVASGQEIETTREAEFAEQVQSEDLEKQPTRKNRHGIALVPQPTDDPEDPLNWSTARKSTTLAILCLASFAGIVQALANSAGFFVQAELYHKSPVDVSYSLSAAIAGLAVGPLLWTPVARQLGKCAVIFWSLILTLCMNIWSARMTSGDDYIPFVVSRLFAALFGSAASVVGSKFIIEVFFLHDRGKCIAIYTCCVLLGTVASATFSGFIVQDASWTVQFWYNVGVEGVVAVLCLIFLRETGWTRPGGPEFPPRPKTRFQEFTATYFFTRRTTPPETIAQTFRAALLPLAIGVSPVTMLVGFPLMLYFSWSVAVTTLLSVFLQEPVEAGGYAFSPRRNAAFTFTQWVGVFVAQAYGHFVNDRLPLAICARRGGKWQAEYRLHSLWVPILIVYPLGLGIFGASLLYHWHYMVLAFAVFLITFSGVAGVPAVVNYVIEAFTPAYANEATGIMNFYRLVFGIALNFFLFPWAAKVGINWCFGMMAFFTIFAFLLIMIPMRYGETLRRYNLVKAKSEEGMMIIRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C7S4</accession>
    <name>A0A0D2C7S4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_00192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239835.1">
        <property type="nucleotide sequence ID" value="XM_016374559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C7S4"/>
    <dbReference type="STRING" id="91928.A0A0D2C7S4"/>
    <dbReference type="GeneID" id="27327275"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00192"/>
    <dbReference type="HOGENOM" id="CLU_074878_0_0_1"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="85"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW19619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="244" mass="26159" checksum="E8C31FB2F0F097F6" modified="2015-04-29" version="1">MATESYKTTLLPLLLEASVLSFGTYTLKSGRVSPYFFTSSLLHTSTLLGALARSYASVLTSPPFSLPLGKDEAGSEAEVPLSPQFDILFGPAYKGIPLSAVVTRELEFSGKQFAGVSYAFNRKEAKDHGEGGTIVGAPLNGKRVVILDDVMTAGTAMREAVSIIKAQGGIVVGVVLLLTRQERVSDSEPRSAMKVAEDELGIPVRAVLKFEDLIEAIEAGQLQGAGPEQLEQMKIYREKYGSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C938</accession>
    <name>A0A0D2C938_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00629</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240270.1">
        <property type="nucleotide sequence ID" value="XM_016374994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C938"/>
    <dbReference type="STRING" id="91928.A0A0D2C938"/>
    <dbReference type="GeneID" id="27327712"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00629"/>
    <dbReference type="HOGENOM" id="CLU_007738_0_1_1"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000011">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="175"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="513"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="604"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW20054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="895" mass="101942" checksum="874D8768168885CF" modified="2015-04-29" version="1">MASLHYRSASATDRRGTQFSSGPARVNSAKYRDYERPSARDTASPIFPDGYSEATDGKHKHTKSENRFSGLDRRKEKATITTTETFITRISPKKGVKVTESYHGRQTSTPSLVQSRPNKDENALTWGPTVSLIPHSSAPLATRITSPPLSRTAPVDLDPTPLGGMTMQEQEKAILDDLLYVFMGFEGQYIRFRDTYNPREEKERLNGPAFDPLPGLDPSLKDLTSSMLSMATHHCAIEAFIEVQSQEEFGSVNHALCAAIRKLLKDYLILIAQLEMKVLTDANFTLHQMHIAIIPTAQCLAQLYSLAQELLKRNSLLEEDLDDSLDDFDPDNIIERLKEGGDLLPGSLNKKRCIGGNVLGLLSHRLSTFSGDPAARAILEMLLRESSRPYMVMLNEWLHRGGINDPHSEFLIGERASIKRERLDEDYTDEYWEKRYYIRDKEVPPQLESVKEKVLLAGKYLNVVRECGGVNISSKIVDTPATFDDPRFLDNVNNAYSFANKELLHLLLTKNSLRSRLRSMKHYFFLDRAEFFLYFLELSDSELRKKQRDVNLGKLQSLLDLVLHQPGSIAVADPFKEDVRVRMNSVGLTQWLIKVVNVQGIDQDNPDSMADQYKTPAQSSSADRQSKDKKEDEKDIIGFDALELDYAVPFPLSLIISRKTVMRYQLIFRYTLALRHLETQLVGCWSTHTKEKAWIHKSSDKRFEMWKRRVWTLRSRMLVFVQQMLFFATAEVIEPNWQKLMVKVDDAECDDVEETKSGLTVKSKPTVDELMQDHVDMLDSCMKDLGLTQAKLLKLHAKLMTGCGMFASYVEYITKSIYEADPSIQAGKSVHGPTDPARMKRIEESIKKYEEHFNRHLKILIDALNWFATTETVSLLSLCGRLTNADVQKRDDLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C9T2</accession>
    <name>A0A0D2C9T2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chalcone synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_00909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240550.1">
        <property type="nucleotide sequence ID" value="XM_016375274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C9T2"/>
    <dbReference type="STRING" id="91928.A0A0D2C9T2"/>
    <dbReference type="GeneID" id="27327992"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00909"/>
    <dbReference type="HOGENOM" id="CLU_034992_1_1_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00831">
        <property type="entry name" value="CHS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877:SF46">
        <property type="entry name" value="TYPE III POLYKETIDE SYNTHASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chalcone/stilbene synthase N-terminal" evidence="4">
        <location>
            <begin position="76"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone/stilbene synthase C-terminal" evidence="5">
        <location>
            <begin position="248"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW20334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="44311" checksum="EF9C7534C70FCAF0" modified="2015-04-29" version="1">MSPSAVNSKVTPPYQRPNLYIHGIGVEYPPYEIKPEQLATLARRHYPSSPALEKVLTINEYTGIDARSAIGTIDHPIANGPEAPSIAELCEVFLDHGVKLSVQACRRALEQWGGDLSEITHVVATTCTNSANPGYDHYVVKQLGLNQSIEKVLLHGVGCSGGLAALRTAANIALGASFRRKPARILVLACEVSSILVRSELDSIHKDQEVRIGVALFSDCASAVVLGNGFSNRYDEEPILELLDWDHRIIENTEKDLGFDVDPVGWKVVLTQRVPKLASAAVPAMFEDLVGSIPELVDAGKFKAADYDWALHPGGATVLSGIEKTMHLKPEHLRASYEIYISHGNSSSATIFSVMDRLLKGETTEHIVGCAFGPGIAVEMMMFKRSVSGSNSGTASPTASLTETLVAEDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCC7</accession>
    <name>A0A0D2CCC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannan polymerase II complex ANP1 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_01724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241360.1">
        <property type="nucleotide sequence ID" value="XM_016376084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCC7"/>
    <dbReference type="STRING" id="91928.A0A0D2CCC7"/>
    <dbReference type="GeneID" id="27328807"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01724"/>
    <dbReference type="HOGENOM" id="CLU_017872_3_0_1"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF2">
        <property type="entry name" value="MANNAN POLYMERASE II COMPLEX ANP1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="450"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW21144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="62252" checksum="8F720B17301E0EAD" modified="2015-04-29" version="1">MNRHHAFSNGYAAHKKRDDEGYNKYSDKSDLENKYIWGMPDLVEDEKHDASFHKKFEPRKRAFHNRARLMRLGGLALGIFVFLLWLFIPSASRVSSWSNTTRSMQDQSDIETLRYYDLEDVQGTSVGWEREERVLLCTPLRDAATHLEMFFSHLRNFTYPHHLVDLAFLVSDSKDNTKELLATMLEELQNDPDPSQPYGEISVIHKDFGQSISQDFESRHGFAAQASRRKLMAQARNWLLSGALRPYHSWVYWRDADVETCPFTIIEDLMRHDKDVIVPNIWRPLPDWLGGEQPYDLNSWQESETAIALAETLDEDAVIVEGYAEYATWRPHLAYLRDPYGDPDVEMELDGVGGVSILAKARVFRAGVHFPAFSFERHAETEGFGKMAKRMQFSVVGLPHYTVWHLYEPSIDDLRHMEEMEVEKRQREEKEAEEAKKLKKAQENFQKVDSQWEKDKQAIAEADEAGKPEVKKDANGKPNTEKDTLKGTPKSEPKTESVQKINTFKDDKEKTGDKAKGGGEGEAQRPAANVPKPGQKKDYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCK8</accession>
    <name>A0A0D2CCK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_01814</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241450.1">
        <property type="nucleotide sequence ID" value="XM_016376174.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2CCK8"/>
    <dbReference type="GeneID" id="27328897"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01814"/>
    <dbReference type="HOGENOM" id="CLU_241013_0_0_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="68"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="873"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1532"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="945"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1051"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1125"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1282"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="913"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1532"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1543"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1571"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1590"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1634"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="155"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW21234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1769" mass="197026" checksum="E64346381D2EA260" modified="2015-04-29" version="1">MISSPPGSPEAARQVRAQSMYSVPSPDPAQKQRPQSMIGRPPPRSNSRMSQSSNHVGSRASDEDAKTSVKVVVRVRPPLGPTDPGFELIPQRFQRSMVQVNTNTSLAVESPQGRKMFIFDRVFGGDTDQEGVWEYLQDSVNSFLQGYNVSILAYGQSGSGKSYTMGTSGPNEQFDPSMKGVIPRAAQHLFENLNGAPTHSRHNSGLKSPTRYSVTSLNQVMRNSKSFPDKGWEMSVTYVEIYNEQPRDLLLPEDAPFTERANVQIREDPRGRIFVEGLNSVRVSSMEELMRVLNHGSTIRQTDATAINARSSRSHAVFTINLRQTKAQGFTSTKDKRASIAGDHFPSHDSPMTVESKLHFVDLAGSERLKNTQATGDRAREGISINAGLASLGKVISQLSSKASGTFVSYRDSKLTRMLQDSLGGNAITYMIACVTPAEFHLSETLNTVQYAQRARNIQSKPKIQQVDDGADKQAIIERLRTEIAFLRQQIRSAESGDRRPGGMSERGDRPNDRENELQNQLLDVQESYGALSQRHAKLISELTKNTETYDQATSLPGESAIDRLRRSQANQEMIEQVVMEYEKTIQSLETNLSTTRSSLATTESSLLEKETKCAYVETVNQQLNARVQKMMDRESNTEQYLHDLEARLDNQSTGSEKNDAIISELRKEISRIRESETNAEDYICTLEERLAEADQDVEIMQRESERLEHLVERQRSLGKLDNLLYELDHIQDKEGKSKLSSKRAPEEDKIIEEEHEQGLNVAEAIELPPAKEDELDEHIGDPADHVVAESDAAGLEKLETAVAQREHLTAEQTNDALPSPAQSKFITEKFEAVSQELFDLRLEHESTVNELDLLSAKYEEALRTLAQMHDSFEEQRQGEISEQAEPVHSPSSPRFLDESQLQEVEDGRELPSSRSLSSELSLAGESSTSVDTDITPVSKASPAMEVATQEIERLQNLLEEHERNIQQVTEQYTRLQADHKDALTTVDRLKSQVQRARPASPSTPGMLRRMTSQSNNAIDRGLRSITSLRSLLVEEFENRPDRMEGAEVHLSAASLELQARLERIQSLEAEVKTVKKDMELKSTIISGLTRERTSIKAGSPVDLNMVSQLRDQIIQKETELKSLHEGYARREQGLQEEIQRLNAEKANGHLTPPGSPDHGKIESLNEQLSALTSKLEASQQAVEESQKKYSRTKSELEAAMASVATLKAQQVSGEGDVASERANTAAAMQNERDNYQELIDSLKHEVEEQRGLNTEYAARVSELQQLHDSLSKDFDAQTELAKSHRSEIASLKTHVAQLEQKVKEADSALESHKQGLKSLHDSHNSQIEEMKLAHAGHLAGYDDQIAEMTKKHEKLVSTYKKDLEHALTTIDQLVSKAQGALGHPTNADMLASHIQDVVDEKCHIVEANLRLKDVNAELERQLDGRQGLLELEEALADANAKIANYQETIRSLANEVANHEETIREKEAQIKKAEAAVDTIKAEKAKKSIIIEELEQQLQSSFEQHHNRVSVIQAQGNQALVEAQQRIASLEKDLDQRRSINDGGSDSGSRTNTMKSQNRPQSPPVDGSVPRSNSISSNLRKSASIASLPSPPPAIPLPPLPTLPGIQVGGATNPSPPQSRHASKEVTLPVTPVSGTAVSTNSQNVRRSSALIEEQENRLRTIEKHLHAEKQLTATLEEALVDLETQSNKLRADAEIWKKKAWSMEEELAGLKKERRSERLSVQAVEEEVKKRREAEAARAQLEERMRLLTVGKDGKTKKRKGSSLNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y4N1</accession>
    <name>A0A0D1Y4N1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230107.1">
        <property type="nucleotide sequence ID" value="XM_016386299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y4N1"/>
    <dbReference type="STRING" id="91928.A0A0D1Y4N1"/>
    <dbReference type="GeneID" id="27339075"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11992"/>
    <dbReference type="HOGENOM" id="CLU_026305_1_0_1"/>
    <dbReference type="OrthoDB" id="4119166at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002246649" description="DUF7580 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="2">
        <location>
            <begin position="201"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="609" mass="68527" checksum="58FFF18BD54F20E7" modified="2015-04-29" version="1">MVTGIETVGVVLAILPLVVNQLDNYVRGIETLKGFRNKRHRRQLEEYSTRLGTQHAILLNSLEQALEGVVDYEDDISDLINCPLGSSWRNQEFQRKLSRKLDRNYDVFVRTTTEISRELQYLSTKLGWDSATTTQMSWDDTGTVERELRKFKDIFSKSVYNELLSKIENANGALQTLIEQSRRRETTRKHRVFKKKPLLKYKNARKHATNIYNAIVHGTCWPCPCSESHCVHLRIEPQALDEDDLKHQTQEAFVPKIRMVFTSKIPSKGTPLWYWQEVETIPVASEPVTVAPSLTKAKSASASTVVTKRTGPDRRVTFAAIVESTLDTVPWPRVNNSLPPPKQISNMCSALCSQNAGDRLLGSILDRSDPTHQYHIYLTDRVDTSVPTKSLADVLEASAKDSLRFSIANQSLMLSRHDRLSLAATLALSVLQYQGSWLKPQWRIQDILFKDHDSGNPTLLDRVYLSAHDVSPTGDSSSLSNGAETSEGASQQLTVAVTSSSLIRCALLFPLALSLIELSLCTPLSSLQTAEDADPVEAISNLKTAVRVLPRVYAESGCRYGDVVDTCLYWPDTKNMQLDDEEFQRTVFEVVISPLLDDLRDFEGKDRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7Y4</accession>
    <name>A0A0D1Y7Y4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein transport protein SEC24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein transport protein sec24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PV08_10315</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231232.1">
        <property type="nucleotide sequence ID" value="XM_016384630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7Y4"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7Y4"/>
    <dbReference type="GeneID" id="27337398"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10315"/>
    <dbReference type="HOGENOM" id="CLU_004589_2_1_1"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="19">
        <location>
            <begin position="255"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="20">
        <location>
            <begin position="329"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="22">
        <location>
            <begin position="576"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="21">
        <location>
            <begin position="670"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="18">
        <location>
            <begin position="799"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KIW11016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="935" mass="102460" checksum="E48368B49578230F" modified="2015-04-29" version="1">MSQYPQPTPPGQDGYGQQAPAGQNYENYETTSPPGVMPAPPQGQAHGGRKKRAYAGQAYEFGAGANAALGGQQQAGGAYPGYSAQQDAAGYPQGGYQQNPVAVQPNTTPMYPGAEAAGGYQPPAAGYPTAGVAGVTQQFGQMDIAQQPPVAAAPQQPQRAPVLNQLYPTDLSNQPFNVAELDYPPPPAILPPNTSVTPSPFANCPPKYVRSSLNAVPTTHSLLKKSKLPFALVIQPYTSLHDVEDPVPIVPDQVISRCRRCRSYINPFVTFLDHGHRWRCNMCNLTNDVPQAFDWDAAAQKSLDRWQRPDLNHAVVEYIAPQEYMVRPPQPLVYLFLLDVSYAAVTNGLLATTARCIRESLDRIPNADRRTRLGFIAVDSSLHFFNIPRDGTENGQTSMLVVSDLEDAFLPTPADLLVPLSECRENIENFLDKLQEMFQNTQNGASAMGSALKAGHKLIGPVGGKMTVVTASLPNIGHGKLEMREDKKILGTSKESSLLQTSNSFYKSFAVECSKQQISVDMFLFSSQYQDVASLSNLPRYTGGQTYFYPGWNAAREDDAMKFAKEFSDYLSAEIGLEAVLRVRATTGLRMSTFYGNFFNRSSDLCAFPAFPRDQSYVVEVAIDETITKPVVCMQAAVLHTTCNGERRIRVLTLALPTTQQLSDVYASADQQAITQYYSHKAVERALGSGLDSARDMVQSKLVELLSTYKKELAGGSMGGGGLQFPANLRGLPVLFLALIKNLGLRRSSQIPSDMRSAALCLLSTLPLPLLIQYIYPKMYSLHDMPDDAGAVNQETGEIILPPPVNLSSERIVPYGLYLIDDGQTQFLWVGRDAVPQLIMDVFGVSDKSQLKVGKQRLPELDNDFNERVRAVISKSRDHLAKGVGSIIVPHLYVVKEDGEPGLRLWAQTMLVEDRADQSVSLQQWMGQMREKVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCG6</accession>
    <name>A0A0D1YCG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_09889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232827.1">
        <property type="nucleotide sequence ID" value="XM_016384204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCG6"/>
    <dbReference type="STRING" id="91928.A0A0D1YCG6"/>
    <dbReference type="GeneID" id="27336972"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09889"/>
    <dbReference type="HOGENOM" id="CLU_020594_0_0_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="165"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW12611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="853" mass="94448" checksum="2E105ED6EDA739A2" modified="2015-04-29" version="1">MTSPRVHETLYPGTSSPLAKWWDESPGATIRSLSFDLPQLLSEMEEYDLDNVNLIGADPLWDSSVFSTAVLDTPRPDCQLEHHQAASPVAPVLRQLNPERVHQRRDQQGIPGDDITNSGSKRSYSSQMADLFRITSPPGMDSSQTSREAPTPRVAKQALRRQNRSCDQCRSAKRACDLSNDSSIPSQKPSRACSLCTIRGVECTATWLANKQSSLRGKKRPRLTAPIFAEEESSDLGLNAMEEHRVDMDVSPAAPEANLAKLTIAEEACSQHFNLYVDVFDIPISHCLFLDSMPPGYSLGVAALSPIKDSSSLSGYLSKADAWIKSCWNLNFNAFGSTVPAPHIFHTVSVLDAVFQRTGAQPYRSSMTSRDVAITETYKWAAIALAARFAPAKSGEKKPLNPESGKYLEYRHDVALAAWEKAKEKVFGNIAATTSFRVALSLLLFGLVPVPGSTNQGQELDEDAEYAFCEGVRRLHTLCAKARQRILVYSQANGSNSVTDSRGSPNGSHDLPHLSPEDSKYILELLGAVEWLINIINAVAIGVSRGKTQAFPSQMSTPLTIHRPHDNGDTSSRPGEDRLWLFRRHDLSNLSLMQTESKSEAFTTIWCKGAHDDVLLQTLRRLSYVVVVIWKSLADLTMAIESAHRNNVGYEENVFQHYETTISLLQRWRSAFGILDSGMRECFDKASDEIWRTVAFTSNDCDLAILLFCDLVQRFEIRLAQQPFTPETERLRGALRLTSDFRKTQRLISAEQVSLVASTCRQTSRPGFEGSSGLKSHIQDIAAHPNPSLMVHLHTLAGNALRGEVHSSISQLEGKRVSELTRSFDICRETVQGLKETLVTFPDIASSDDLEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YES6</accession>
    <name>A0A0D1YES6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233772.1">
        <property type="nucleotide sequence ID" value="XM_016383069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YES6"/>
    <dbReference type="STRING" id="91928.A0A0D1YES6"/>
    <dbReference type="GeneID" id="27335827"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08744"/>
    <dbReference type="HOGENOM" id="CLU_983642_0_0_1"/>
    <dbReference type="OrthoDB" id="4144003at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34229" checksum="B245BC9C20CB3489" modified="2015-04-29" version="1">MERYHFVVKDAKSASLSRGDDEETYRIRSHAQTRRRQGEKSLPQSVASIPKERSRGRRPNSDNQETTTSREHSECREVNSTTIDSPFFSDGTTVVQSHWTHYFRRAARGEELDHPSVVSISVQPSGNSIDPFNSTNMIHHPSAYQLMRFLQSDFNSSNFHAEALGRPLEAISRTGPCFRHEAAYSERMRDALQDDMLMLSMLAYASGAISWRYGVRFEDLPPEYFIQQTYRNIRERLRRSEAVEEALLWSIYGLAAAEMWLFNFDAAATHMRAVQVLISQIGGMTKVSPLIMESIILGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YG27</accession>
    <name>A0A0D1YG27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234187.1">
        <property type="nucleotide sequence ID" value="XM_016381085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YG27"/>
    <dbReference type="STRING" id="91928.A0A0D1YG27"/>
    <dbReference type="GeneID" id="27333835"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06752"/>
    <dbReference type="HOGENOM" id="CLU_461531_0_0_1"/>
    <dbReference type="OrthoDB" id="10566359at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31192">
        <property type="entry name" value="SPERM-SPECIFIC FAMILY, CLASS Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31192:SF4">
        <property type="entry name" value="SPERM-SPECIFIC FAMILY, CLASS Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002246934" evidence="1">
        <location>
            <begin position="23"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="538" mass="52092" checksum="2D69A92916C273C6" modified="2015-04-29" version="1">MFGKLLYSALLASWTLSVFTLANPVLPRQESSVWSDWTASAGSSTTDVGGVTGGCTGHTVTSISVITTTLSGGGDDSSTAPSIITRTITLPPSSCTPVSPGSTGSSCVAGTVTTTVVGSGPGGSTITRTVTAPGSGFTTTIISSVSGGISTVTETRTVNAPPSTTTVVSTVQAPGGTTTVVSTVTQPVPGPTVTVTSTQTGPGQTVTSTVLQPGTPTTVRLPPETITVPGPTVTQQSPGSTVTSVVTVAGPGTTSTVTLPAGTTTVVQTTTVVNTVQGPGATVTLPGATETVVRTTTAIGPVQTVTSVVTIPGNTNTVTVPVTVPVTVPAGTITSTRTITVPGGTSVITSTVTAPGGTSTVTVPVTVPAGTITSTRTVTVPGGTSVVTSIVTAPGGTSTITVPVTVPAGTITSTRIVTVPGGTSVITSIVTAPGGTNTVTVPVTIPAGTITATLTVTAPVGGGGTTVVTSTVTAPGGTNTVTVPAGTVTRTVATGGGTNVITSVVTETAPCGSTVWGDWTSAPATATAGVRRRSGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YI53</accession>
    <name>A0A0D1YI53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234832.1">
        <property type="nucleotide sequence ID" value="XM_016381730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YI53"/>
    <dbReference type="STRING" id="91928.A0A0D1YI53"/>
    <dbReference type="GeneID" id="27334483"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07400"/>
    <dbReference type="HOGENOM" id="CLU_811426_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012972153" evidence="2">
        <location>
            <begin position="16"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="342" mass="35036" checksum="1BDF308E9B54968B" modified="2015-04-29" version="1">MKSAVVLGLAAVAVAAPGGPGGWGGGQGGWGGHQQGGESGGNWGDWNGGHGQWPPSEETSTFSPQPAPASSSAIPEPISQGWGDWETTTTTTTTPSPSPISQTTTTTTTPSETVWLDWTTTTTTPSPSPISQTTTTTTPSETMWLDWTTTPTTTTTTPTPSPISQTTTTPSETMWLDWTTTTTNSVSPAPAETQWADWTTTTTKSVPVSPISVTTTTKEAWGDWTTVTTTTTSIPVSPISITTTTKESWGDWNSTSSVPVAPISTATESWGDWTTTTPPPAPITTTTPPPAPKSSTTKPVAPSSTTPVAPVVSTFVGEASAQFGGAKKIAGAAAAIAVAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJL1</accession>
    <name>A0A0D1YJL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_05211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235382.1">
        <property type="nucleotide sequence ID" value="XM_016379555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJL1"/>
    <dbReference type="STRING" id="91928.A0A0D1YJL1"/>
    <dbReference type="GeneID" id="27332294"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05211"/>
    <dbReference type="HOGENOM" id="CLU_072993_3_0_1"/>
    <dbReference type="OrthoDB" id="2096797at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02233">
        <property type="entry name" value="cupin_HNL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047263">
        <property type="entry name" value="HNL-like_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43698:SF1">
        <property type="entry name" value="BLL4564 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43698">
        <property type="entry name" value="RIBD C-TERMINAL DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW15166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="152" mass="16582" checksum="EA945C621598365C" modified="2015-04-29" version="1">MSYSDNVIVKKRDTSIKSPISSITQHGRVEGAESISSEAFGTFVGQVWLDPMLKSGDDILVANVSFQPGARTNWHRHEKGQLLKVTGGSGWVCDQGQKPKRISVGDIIWCHAGGIHWHGADDGSFMVHEAVSLGGIEWYDPVDEEEYAAKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKG0</accession>
    <name>A0A0D1YKG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_05507</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235677.1">
        <property type="nucleotide sequence ID" value="XM_016379850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKG0"/>
    <dbReference type="STRING" id="91928.A0A0D1YKG0"/>
    <dbReference type="GeneID" id="27332590"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05507"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_1"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF4">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="15"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="414"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW15461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="451" mass="47820" checksum="2CE1F9CA20CB3815" modified="2015-04-29" version="1">MAAPVLPNSGPQTFRVLVLPGDHVGPEVMKEAIRVLDVVEASSQGRVKFQYNWQICGGCSIDKHGTPITDEVLRIAKEESDAVLFGSAGGPEWGTKPPNPEAGLLRLRQHLDAFANIRPCRFYSRSLVEHSPLKRSIAEGTNFIVLRENCSGAYFGPKVEEPDMASDSWTYRREEIERCARVAAALATTMGSDGQGNGPPAVVWSSDKANVLASGRLWRRVTSDVFAKEFPHIDLRHQLADSLSMLMVKNPRMFNGVIHTDNTFGDMLSDQAGGVVGTLGVLPSASLCGVPDGRSRCHGIYEPVHGSAPDIAGKGLVNPTAQILSAAMMLRYSFALHSEAAAIEAAVEKILDARDIGGLEIRSGDLGGSATTSEMGDAVCRVLAEILDGNSTGVATGQNGSATAAAAAAATTAPGDMVSPVHETHSGENKHWENLLKKEHGPTGPGESLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YLQ8</accession>
    <name>A0A0D1YLQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236177.1">
        <property type="nucleotide sequence ID" value="XM_016380350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YLQ8"/>
    <dbReference type="STRING" id="91928.A0A0D1YLQ8"/>
    <dbReference type="GeneID" id="27333094"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06011"/>
    <dbReference type="HOGENOM" id="CLU_004083_9_0_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="682"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="733"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="743"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="775"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW15961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="915" mass="102651" checksum="A0ABE77AAB1C7ACD" modified="2015-04-29" version="1">METLRMPDDTPPSGDKDRSQSQRVRRRNRMITSCLECRRRKLKCDKLHPCTNCSKFSRDCLFLAPALDSVSQQRLNEIKEKMGSLERVLEQDVARREGKSTPSSSENSQRRTSADLPGGEYSSSDNEAAVPDDIKGLEPTPMAVIDGAYEDDTNDDVLDLGVKIGKMSRLTERLGGFFRPRIGEEVASQLDDPNVDHRTADEKLSAVPQLPDHGYDFLAPGPTYIAPGSGFLFGDVGSKRSLINFLPAKGAGDLLIRKYYENVHFPVRVVHWPSFQLHYDNFWTAVLAGLEPPAWQQSLVLATLFSAVASMADGDVAAIFARPKSTVLGNFQTGTEVALSKASFLRATKLETLQALVIYLIPMCRDQISRAHSVIVGMAIRLAECMGLHRDPEDVYGLNPVECHVRRIVWFQLCALDFRTCETQGPRPGIKREDYDTRFPMNINDTDLLLANPQEAKDQWTDMTLSRIRFECLEMQRIIWFDRIRLEKKKISLTHLLGKVESFRRAMESKYNKTFDLEVPIQNYAHLLMTLLIQRMYVMILHRYLNNANNVVPERLGQLTVQSALKACESAIAMERLPLLEKWKWFGGAHQQWHMAFLLLTIIYNEPHMRDADRVWDVLDYVFEPDPTLSRTQRARTIIAALRDRTNVYRELRRIRIPISMANRPASLSTARIISPNTVGANSGLQSISRPSDAGPPTSNLELPPDIKYSTDTTWSFDSPATLYMRKLNSAPVRGQQSDIATKSVSPQPAQQVPTQQQKASPQPQQQQQQQQQQHRPSWSEPYQTSPGQQGDFNSPSDSGTNESWPPLIAPDQLGWRTVLNTSSAPSMPVVSMPSIPAIGTTSIPNDAGDNPYGIGSGFPNDQVNIPQFQPSNPRGDSVMLDINWAEWDQLFPPDATPGVFAGGNGFGVDMGQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMQ8</accession>
    <name>A0A0D1YMQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236547.1">
        <property type="nucleotide sequence ID" value="XM_016380720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMQ8"/>
    <dbReference type="STRING" id="91928.A0A0D1YMQ8"/>
    <dbReference type="GeneID" id="27333465"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06382"/>
    <dbReference type="HOGENOM" id="CLU_360162_0_0_1"/>
    <dbReference type="OrthoDB" id="4119098at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF10">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN YAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="235"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="766" mass="85388" checksum="9617834948055708" modified="2015-04-29" version="1">MPPFHAFRDGWTDDDESDLEIYEQTAPLQKQKPQRERDASTDVELVDHARTSKGTPPPTSLHSPRARVQRERYVPVDKSIPEVSSRGSTPEFPTTEQEEDEKWQEEFLGKGDKEEWLELSESGDGDEETDQQKYDNDTIEVSYEERTLLGESDELLNGTPSLAAQWQNAVRSPSISISQKPPHSPEPQQSRPRSASTQKLRGNASPSLAARPHREKKDHPPSKTAATPGETPPQVYAISRSNVPVFEIKINGISVMRNQMDSWVNASSMLRAIGVKDGTMRRKILVQTGGPQRVTNGGHWFYQSTWVPLATARHLATMYDTEDATLPLLEISPSDPIERPGDIREAVRPPTNGNPVSVSPQRSASPYEDGELENIADRSAQGHGRLATRGDWSNSSDSEDDVHLPATANRPGPTRSMVTSDLPNTRTALLDRMNSGKKRHSDIPDHSGERPVPPAKRARIESLSAFPPHVSSQDTDSITASYSRGRRDNEKQAAKELRGLLPQRYLDEGADLDGRCNPTTRIIKSAIAFIADLSDQAIGGTTSKSQRRAKKQGEEAGDGHSPARSQPKTKDYNETSSESLTQALIQTLHHSETRIVTSWEGPDHMANPPLRGLDVGPRRKSSDNYSKSKSAIQSLEKWHNLDGLQRVFRRREMADNTAMYEAMQKINRQPIWDRLTEDEKERIRTDEKKAVLQRRFEQGKSHSYFVAQLIDVCKQCGVTECDMLNMVLSKLPKARAAVIDLFNDVVEVDESGKLTIIKPPAGKVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNF0</accession>
    <name>A0A0D1YNF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03789</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236817.1">
        <property type="nucleotide sequence ID" value="XM_016378140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNF0"/>
    <dbReference type="STRING" id="91928.A0A0D1YNF0"/>
    <dbReference type="GeneID" id="27330872"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03789"/>
    <dbReference type="HOGENOM" id="CLU_002227_3_0_1"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="283"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="803"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="825"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="942" mass="103324" checksum="7DEE4CC0CCE2E1CA" modified="2015-04-29" version="1">MFTFTPLLGAQSNSRSSQSILELDGGVKILVDVGWDERFDTRQLAEIEKHASTLSFILLTHATTSHVGAFAHCCKHIPIFSQIPVYATPPVIAFGRTLLQDLYSSNPVAATFIPGSGSPEDDSSVDDKSRSNILRQAPTFEEINKFFTLITPLKYSQPHQPTPSHFSAPIEGLTLTAYNSGHTLGGTIWHIQYGMESIVYAVDWNQARENVIAGAAWFGGVGGAEVIEQLRKPTALVCSSVGAARAGLAGGRKARDDALLGHIKSSIAKNGTVLIPTDSSARVLELAWILEKAWTDPVLKGAKVYLASRSANATLRHARSLLEWMDDSIVREFEEEDENQTQSRRRNGSKQINGTSKSSRPFELENIKIVERKSQFERLLKAEGPRVILASDVSLDWGFSRSLLEHMVQRPENLVLLTEKAEMRPGSLSPSQVFWTWFEQRQDGVALEKTLDGEQLEQVHSGGRMLKLRHAEKASLSTQESQRYQQYMATQRQIQDSLAANEQDQGGVDDNLDDESSTSSEEESEDEQQGRVLNVSSALGHGARNKVALSDEDLGINILLRKKGVYDYDVRNKRGRNAVFPYTHTRRRGDEFGDFIKPEDFLREEEKEEQEAQTDSKSMALLGQKRKWSEADNAREMHQKRPRQGGPASAADSGDESESDESDEEGQMEIEGPQGPAKIVFSTSEVTVNARLAFVDFAGLHDQRSLQMLIPLIGPKKLILTSGNPSDTLALASDCKELLGVKAAGVEEETSTEIFTPQEGQTIDASVDTNAWVVKLSRELAKTLRWQNVKNMGVVTIQGQLKAEGEQKADVEDDPQSKKQKIDTEASSQTTPQPGLSIQPVLDVLPASLAASTRSVSQAIHVGDLRLAELRRIIAMDGHTAEFRGEGTLLVDGMIAVKKVGSGRIIVEGAPLGVTAMSTSTADNFTRVKQKVYEGLAVVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQH2</accession>
    <name>A0A0D1YQH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237687.1">
        <property type="nucleotide sequence ID" value="XM_016379010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YQH2"/>
    <dbReference type="STRING" id="91928.A0A0D1YQH2"/>
    <dbReference type="GeneID" id="27331748"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04665"/>
    <dbReference type="HOGENOM" id="CLU_367597_0_0_1"/>
    <dbReference type="OrthoDB" id="5383784at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="763" mass="85131" checksum="95A72D3FAFFF46D7" modified="2015-04-29" version="1">MGRKAHLARMALGRSPFDAPLQDEDGEFILGPNVQHATARNYVQRFDSRGHPENLASEASRRRLRRAQNEVLSTVGVVVRKAKMNRSRWESMGDDQKHLLLLDENIAGANIGIVESVVLKMSTRWLSALRRRILVFKSYVGLSVPRILRTEWNVVGPWSVLFAGLPFGAVSAVSQALRDDILDEHRFTNLLRSSSTSPAIKFANLIGSHRLDFLKLLCSSLIVSSLRMLWFAAEYPLYAFSTLQSLYLIPAGAFPHPWSFVPFSNISPIQLPRPLPDGSLTSVVIYVTRLCAHPFTIAYVRDQIGKFIYTKLYILARHLVVKPDRPDRISLQSARANSSVFNDTTIPGLGADGKALSSHNEPSPFTETIKTLFPALFWLWEKILQTQSASLTVELTPDMQEELVQRSMMYYRDSIRRQRRDYGATRHSSRTLRVMAIRDAFADFGLDPDQAMVDIFELAEGLHVSARDDASTATPEPEADILTSPMVIVAEADGALHVQPARTADASQLESQHSPGDRSPENLQEANGADATRTDIVEGISEMPTLDERTVPLERLLLTAPSDRLAIHVDEPIDAQLFPSPPPSSPPSPPELGINRAQSLIATAPRPVRRETDIYNEQARPIRQDLFSRHHSLRAQEEDDGVYRVTILSNHPAEAFALNVASAIEPLLLLPLDILFFRSMVRNFTTQPTSYGLSLSTGSLLTRTLPVVFNFGADEYNGSSAMLPILGNWVITLATQSIINFTIWKMTTHLILRLGRRFGWGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YR37</accession>
    <name>A0A0D1YR37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase mitochondrial F1 complex assembly factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237937.1">
        <property type="nucleotide sequence ID" value="XM_016379260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YR37"/>
    <dbReference type="STRING" id="91928.A0A0D1YR37"/>
    <dbReference type="GeneID" id="27331999"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04916"/>
    <dbReference type="HOGENOM" id="CLU_054226_1_0_1"/>
    <dbReference type="OrthoDB" id="16535at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39844" checksum="50B532A8AC04B94D" modified="2015-04-29" version="1">MAAPYSFALRRTIHHSASLLRSQPQRRYARVHDVRFVTTHRDSTRILDRYKDKLERKAKQEGHNSISSLKEAYAEKINEYKRSATDPPTEQSTPAPKRSSLQQPPPPAPTPQPSASSVQSQNQASEGKPESSAPGIRPLSSYLDLEKVAALSNKEVEYIWRVRHADDPLSLCAVIPLDTYNRIYRTARTHPQFVLPLPRPVADDGSGDVKQSPQGFEGGERSAADIHFLQWGFHPPASAPASPRVNTLNSHISTVLFTHLAAFKVHGAYAQPHTTVTHHLDLADSHGIVLLSGSVVENRGVSVEEGRWLLMCLQRFYDYEGHGGGIGREKRQGLLEKFSKGDQGFNIQELVDEAERIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRR9</accession>
    <name>A0A0D1YRR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238147.1">
        <property type="nucleotide sequence ID" value="XM_016379470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRR9"/>
    <dbReference type="GeneID" id="27332209"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05126"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26278" checksum="DD0FB92EACCE5379" modified="2015-04-29" version="1">MSGINALGFYQSTIFEQYLRLSPTIARVLSACVFTFQTCCSPIGVLAVDKFGRRKLMMVSALGMGSCMAIVAGASSQSHNVACVGVACAFIFLFSLFFPIGFLGLTFLYASEISPLMARVPITAMSTGCAWIFNFFIAEITPTAFATIGWRYYIVFACTNMFLILPCVYIFFPETNRCSLEGVDQIFRDSKDCLQPVKMAARLSRGLLDEAVQTDQKLSNEMVECCEAACERDDRGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YS31</accession>
    <name>A0A0D1YS31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_02298</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238227.1">
        <property type="nucleotide sequence ID" value="XM_016376657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YS31"/>
    <dbReference type="STRING" id="91928.A0A0D1YS31"/>
    <dbReference type="GeneID" id="27329381"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02298"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="57"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="556" mass="60510" checksum="20E7BFA9831F13D4" modified="2015-04-29" version="1">MAETKTQYAGKAEGDMESTLAMTTTSCRGDLADLPGGLDESVLTEVKELKQGLKQRHIQMIALAGTIGTGLFLGSGRAIAHAGPLGAFLGYAIIGMAAASVVLAVGEMGTLVPLSGGIVRYSEYFVDPALAFANGWNEVYGYLVSIPSELVAVAVLVEFWTTSVSNAVWITIFGLLMLGTAFLFVRVYGEIEFFFSTLKILLIIGVNIMALVITCGGGPSGESIGFRYWKHPGPFVQYLGISGSLGRFLGFWTVMSNALYAFSGIENITLPAAETQNPRQAIPKATKRIFWRILIFYIISIFMVGLVVSSDDPRLLTGSANAARSPFVIAAKDAGIKVVPSIINAVVLTSAWSSGNANILGGPRILFALAKHGHAPAFFTRLNRFGVPYIAISLFGIFMCLGYMSLSSGASTAFTWLQDLVSVSTLVNWMTICITYLRFYYACKAQNIDRHTKLPWAAPFQPYSTWASLGMFIIIYLTGGYKTFMRGRWDTETFISSYLNLPVVIVLYFAYKYIKGTKLVPLAESPIRGFILLAEANPEPVPKPKRGIQKFNILWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWH3</accession>
    <name>A0A0D1YWH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PV08_00220</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239862.1">
        <property type="nucleotide sequence ID" value="XM_016374586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWH3"/>
    <dbReference type="STRING" id="91928.A0A0D1YWH3"/>
    <dbReference type="GeneID" id="27327303"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00220"/>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_1"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="893"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="942"/>
            <end position="965"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="994"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1029"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1085"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1090"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="ARBA" id="ARBA00022842"/>
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            <dbReference type="ARBA" id="ARBA00022967"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KIW19646.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1120" mass="122896" checksum="5DC216E812322507" modified="2015-04-29" version="1">MGGKGESAEQNYPKQPFLLSVDEVVDHLQTRIESGLANAQVQQYQDKYGPNKLSGDGGVSWYSILGKQISNAMILVLVLAMALSYGVEDWVEGAVITAVIVLNVLIGFYQEFQAEKKMDALRSLSSPSAAVVRDGTEMTIPSGEVVPGDIVSIKTGDTVPADLRMFEVMNLECDEAILTGEALPVAKEVDFEAKHGAAKEDLGLGDRLNIAYSSSTVTKGRGRGIVVYTGMSTAIGGIAASMQGKKRKPNRSMSRKKHGPMQPVKGGALRVWDGIGKFLGLTEGTPLQIKLSKLAYVLFGCALLLAIIVFGVNEFNVTNEVAIYAISTGIAIIPESLIAVLTITMVVGMTQMRKRKVVVRQLSALEALGGVTNICSDKTGTLTQGKMVTRKAWIPGVGIYSVDNSSNASDPTEGTISLGKAPGSRKDAEAERQARQEALDRKRSVAGVLFDVPQEKLQKDNQKTAHPEEPVAVEDNPEVTPELRAFLEAAALCNLATVRKVNEDGTEQWKTTGDPTEIALQVFSHRFEHGKKKLEEEHGWTQKMEFPFDSSIKRMTVVYQKPNEDHSTIFTKGAVERIIDLCTTVGIGEHEEEITPALKESILEQMTFLAEQGLRVLALARKFTPLDIAEHSDIDRAEVETELTLLGLAGLYDPPRLETKGAVQACTNAGITVSMLTGDHPSTATAIAKEVGIIPRNMGQLAPDVAAAIVKTATEFDKMTDEEIDALPTLPLVVARCAPETKVRMIEALHRRRKFAAMTGDGVNDSPSLKLADVGIAMGLNGSDVAKSASDIVLTDDNFASIVNAIEEGRRMFDNIQRFVLHLLTSNVGEVILLICGLGFKDSTGLSVFPLSPLQILWINMLTSSFPAFGLGREKASADVMERPPHDNKKGVFTWELITDMLVYGTIQGTCCLMTFVFIVYGPGPDGLGEDCNRKYSESCNVVFRARAAVFAELTWLILISAWEFKSMRRSMFRINPHDTRAFPFFADIWENQFLFWSVTIAFFSVFPAVYIPGLNTNVFKHKGISWEWAPAIVCVFVFVSGMEAWKYVKRAMGWFEKEETEGMKARRHQRSALNLRQGFFTMARSFTKSKSEEKRTPSSHDEKEDSSRVVSMPRSREVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXG1</accession>
    <name>A0A0D1YXG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016374896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXG1"/>
    <dbReference type="GeneID" id="27327614"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00531"/>
    <dbReference type="HOGENOM" id="CLU_066252_0_0_1"/>
    <dbReference type="OrthoDB" id="4107213at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="429" mass="45568" checksum="EA2DEA172AD654EC" modified="2015-04-29" version="1">MSQASPEVSSKPSIFAPYLSESLASHLSSAPSPIDIDSLSRTPLSRLQQTALPNLGLIELVSSADFTTLYDDLYVASFPRRPERENSDLIVARLAAQAANTRTGLAPYRIVGLRDKQGKAIGAAQFSILPLPLRPRTDIDTTDAYNDTLQNGETNAAGPSSPPPAAGLVVPYLQYIYIRPSSRRQDMSEVLHTFVLAVSAADAATLSFPTPSNLPSPSSSVLVPKSNHDVISASGSSGLNGGSGSSGSSRSSNAGGGAVTTYVPFTLFETEPPDHGVDAPSRSYALERSKIHTSTGGVAVVLLRRPPGSDPSSSSSGRPTAGAEEGEEGEERGGERRQRQILSAHVQPGLEPDDPPLTLVWVIRPSPNPGISYDIRRIGKDLVAAYYQSLRDEGFPESNIALAESMVEERCRDADFHLMPLGEVSDFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZL3</accession>
    <name>A0A0D1YZL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016375701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZL3"/>
    <dbReference type="GeneID" id="27328422"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01339"/>
    <dbReference type="HOGENOM" id="CLU_038732_9_0_1"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="352" mass="37246" checksum="E8D76EE473E9941E" modified="2015-04-29" version="1">MTQNIFHADYPWTSPDVPLVVSAPMMKITLGSHAVSVSSSGGLGFLAGGFDLTPLANDLAEAAEFAKAQEVPLHNGCLPIGVGFQNWGSDLQLALEAIKKHPVAAVWFFAPKQLSDLLEWAREIRTATENKTKIWIQVGTVSEALEVAKTAKPDVLVVQGADSGGHGLAHRASLLTLLPETVDALAEEGIKIPIVAAGGIMDGRGSAAVLALGADGVALGTRFLAAKEAVIAKGYQDEVLRVSDGGVSTAASTIYDVVRNIHGWPQTYNGRGVVNRTYQDAKHGMSNEENVQLYKKAMQQGDSGWGPEGRMTTYAGTGIGLVREVLPAGDIVKQVQQETVKVLQKSTARFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0D3</accession>
    <name>A0A0D1Z0D3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241227.1">
        <property type="nucleotide sequence ID" value="XM_016375951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0D3"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0D3"/>
    <dbReference type="GeneID" id="27328673"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01590"/>
    <dbReference type="HOGENOM" id="CLU_014603_0_0_1"/>
    <dbReference type="OrthoDB" id="10045710at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="480"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="600" mass="64698" checksum="BC8A4D146B074FB5" modified="2015-04-29" version="1">MTEKQARRPPVAPKPSFIQQDASALRVSPVPSPAVRGATLAFAPTSAKASNPTSHNPAAGALLAASLAASKKPQTPQASKEAKSPRPNAPWAQAPPSSPRGRMLTDSKVPVAASELHSDHPPPPPASGPRLPRSTSAVAAAAASATASTRTSPVPIPGTRKPIVYLGPPETRQEGRPRARSTASHNDGGLSVSQSSDALAGAAAASMAVAAAHIQSGFDDRPRHELGSIPRLTLPSSEVSVTSSPSPSVTAAAVSASRNAESVEGRRRGQSTSSRSTQLDNAPSVSTWTDRSWHRFIPSPQESESENDSAQQEILTPDRVLPAPIPLRSSRAAMIAQETPDSKGSPALDTRTKMTASSLADAMVASSLASQLTGSRNASPKPRPPPPVPRRRSKSIGPVENVRHHLHFPHLRSETPPPPPPLKPLPVRHMRQTLRTQSSDHDEVHKEVLHKRGRGHWTRHPNKHHEGDRKRWRDKITERERKRYEGVWAANRGVLIELDPELAVSGHSNDTTPVSDLVVNVVVRDIWERSRLPKDVLEEVWDLVARPGAKALNREEFVVGLWLIDQRLKGRKLPIKVSPSVWSSVRHTQGVKISNRALQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z1A4</accession>
    <name>A0A0D1Z1A4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241647.1">
        <property type="nucleotide sequence ID" value="XM_016376371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z1A4"/>
    <dbReference type="STRING" id="91928.A0A0D1Z1A4"/>
    <dbReference type="GeneID" id="27329094"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02011"/>
    <dbReference type="HOGENOM" id="CLU_009665_6_4_1"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW21431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="429" mass="47269" checksum="385DDC8ED986E38A" modified="2015-04-29" version="1">MGSYQETINVAIIGGGPAGLAAAISLSKLPFLSTVLYERNPEPQEVGAGISLSYNAWKVLDLLGAADGVKGFSKADTRQRNGYTGEVILLQPHPENSDLDPRGAIRARRTRLQSGLLAKVPDGVIKYGKKLVSAQDVGSQGVRLSFEDGTDALADLVIGADGIRSVIRKTLYPDHKIHFTGNTVWRTLVPRSSLTHIPDVTNGTSWWYVNGGHAYLSGVDDSSEVPLEDQLFELSVRSYHEPDIPGRTVSWGIPATNERVQARFVKYDQRVRDAIAAVPEGAWKEFANYAGPGPEKITGWNKVVLIGDASHPLHGAFGSGATFGMEDGWLLAQALEREYSRGSERVVEGALQTFEEIRLPYYQRMYSYLDTQRANAAKVEEEGKAFDKALEVRFKSFGIGQENKLDWIYKHDIGKVWSDYLKGIKEFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z1N6</accession>
    <name>A0A0D1Z1N6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241767.1">
        <property type="nucleotide sequence ID" value="XM_016376491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z1N6"/>
    <dbReference type="GeneID" id="27329214"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02131"/>
    <dbReference type="HOGENOM" id="CLU_096170_1_1_1"/>
    <dbReference type="OrthoDB" id="5388322at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="187" mass="20757" checksum="7C86B11C932F2E00" modified="2015-04-29" version="1">MAFNAKNLQYNKQEPSFLRKLKGEYGGLDGRSNVQIARPKKDRLKTGDGDEDEPLIVDESGETVEKAEFERRQRQGSQTVLEDGSSTEKAERDSKGGEQQQQQSERQKVTEIGSSANAKKRKVGKVVTSDEVDDQGDGNAEDGQSKTKNAQKPKSEDKDGREVKTPKKDQPKKKGKKIKLSFDDAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZCM8</accession>
    <name>A0A0D1ZCM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_10096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231013.1">
        <property type="nucleotide sequence ID" value="XM_016384411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZCM8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZCM8"/>
    <dbReference type="GeneID" id="27337179"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10096"/>
    <dbReference type="HOGENOM" id="CLU_043966_2_0_1"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="9">
        <location>
            <begin position="60"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW10797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="424" mass="46236" checksum="D445A180C783DA32" modified="2015-04-29" version="1">MTTIPTPPSTTLSEPPSPTERRITVSFVDPFDETDDMSASNQIIKTTTTTITPIRMHPKPIYLIVATSLNPPMGIGNNGDLPWPPIKADMAFFRKVTSHVSPSEQTVPSRMFNAVVMGRKTWESIPLKFRPLSDRLNVIITRSKSSDLGSRIIEELKSSTGNKGEQWSMHEFAMSAKPSKSKTSGKNSRSAILTPPPSATAHHAPILISPSLQSILALLSNPSVIAGPTSASTSGPPALTVNKIFCIGGAEIYRQILSMSSAYTDRYALKKSANPAADSETDTDTDGEGDNSDFDVRILQTQVRKISAKPPPPSDSSPTALSKQRSPEPDFECDTFFPDLLPADPSIKSTKWKPLPAEWLDEWIDGIEVPQAQSSQATDDSDAEEESSGWYRDEKANVEIRVVGWERRGARSDSVASLPKDFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZD03</accession>
    <name>A0A0D1ZD03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_10186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231103.1">
        <property type="nucleotide sequence ID" value="XM_016384501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZD03"/>
    <dbReference type="STRING" id="91928.A0A0D1ZD03"/>
    <dbReference type="GeneID" id="27337269"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10186"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF3">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE SRDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW10887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="291" mass="31321" checksum="E19A272603A5BDE7" modified="2015-04-29" version="1">MPRTILITGCSDGGLGAALAIQFHRRGDRVFATARNPAKMASLTALGIETLKLDVLSDDSVKACVDEVSALTGGTLNMLINNAGAGYSMPIIDISLDDMEKLYRLNVFSVVRTTQLFFPLLRAAAPDATIVNQTSAATIITVPYQGAYGSSKAALDNLTQVLRLEMMPFRVKVVDLHTAAVKTHFFANVAQQPGSTLPPNSPYAVLKDKVQAVMNGDMEGVKQQDLDLWAKNVVNDLSKRNPSAQIWRGASATVVWLASFLPLGALDGTLKKMTGLDVLEKKVQEETSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZD53</accession>
    <name>A0A0D1ZD53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231133.1">
        <property type="nucleotide sequence ID" value="XM_016384531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZD53"/>
    <dbReference type="STRING" id="91928.A0A0D1ZD53"/>
    <dbReference type="GeneID" id="27337299"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10216"/>
    <dbReference type="HOGENOM" id="CLU_007254_1_0_1"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="751"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="447"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="794" mass="88332" checksum="8142562DDDA833AA" modified="2015-04-29" version="1">MGARQRAQARPKKGNSAKNPKWSQKQPTSSVKFTELNPRNRQQALLSDWQDFSDSASPHARTGHFTMSEEARNTERHTAAWGPSRLRDRAVVFVSAGTLVREEPVMESKESTQGTDQSAGDGDSVQLDARHDSVEQDQVTVAAVHQPVEEVAPTTTTESSVTNTPAPRRYSASSVSSDEILFTGRQNRAEPRPRKVDISPNPPSSLPTSTKHDSDLQAGETSTGSPPQKDFTPLSHHIGPIPLRKKNVDRRGRPLIFSSRREEEEAIMNDYIANLVFDDDSDEEEEEDSAPTTAKPSRRDEHFKLHGNATEAPFKVQTKPPTRYEQSKTAPSQAIDWDSADLEDFDDLSTTDEEVVEVSQVLRHRERPSGPQYLVTLPGQDASEARWVLHTKLTSVSARDEVSIFHDIQAIQFENTSDDLEADDTGSDDDDEFRDDADDDRESEMEENDRIIDRVTRMSDEQIARAFAKQAEMGIGGDELLLFDGQVDDEDDDQDMDEFIANDDFIKFSSKKHISSRGKSKRNRRQRDTFPPAEAFADALDQDPYGAFDIMDFDRPSLRPKNKGRKSDPFEWALEDEELAQHLSSTWSKDREKKAARKRERQEAREDALLEAAERNSPAVIKAEIRRFLVQEIDVLELAPMEPTARAGIHRLAKALKLKSHSEGKEGRGRGRYPVLTKGPQTPHYTIDTVWQIDNLIEQRRFFPRQKGGFNGASNPRARVTGGRRGGGGAMSGATYMNGDVVGASAPELGADNKGRAILEKMGWTSGMGIGAVGNKGGLEAIKHVVKTNKAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZEI4</accession>
    <name>A0A0D1ZEI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor IF2/IF5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_10692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016385006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZEI4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZEI4"/>
    <dbReference type="GeneID" id="27337775"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10692"/>
    <dbReference type="HOGENOM" id="CLU_026663_0_3_1"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="249"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW11392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="381" mass="41465" checksum="8DC56BED468C0405" modified="2015-04-29" version="1">MAEVVSKQNVTHSPHAVAVAAGSQLKPPASRPTAQKSNPFNIATQTLLQTNNTDPHTTQQDAPQPPHVRKPRKSVAFSGDDTIMDENGEISEAPTNTAEDKPTAEKHSSPPDDKAVDEMTDMFAGLNKKKKKSSKTKTADGEAGADDAAAAGDEAFDPTVLKKKKKKSTKSKTEGGEDFAAKLASAGLEPGSEDQATSEQPQQEQSGDMLTGTGIWSHDANTPISYNLLLKRFFLLVNEHNPDILSSGSKSYKIPPPQCLREGNKKTIFANIAEICKRMNRNDEHVTQFLFAELGTSGSVDGSKRLVIKGRFQQKQIENVLRRYIVEYVTCKTCRSPNTELSKGENRLYFVTCNSCGSRRSVTAIKSGFTAQVGKRKRLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZEP2</accession>
    <name>A0A0D1ZEP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10727</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231643.1">
        <property type="nucleotide sequence ID" value="XM_016385041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZEP2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZEP2"/>
    <dbReference type="GeneID" id="27337810"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10727"/>
    <dbReference type="HOGENOM" id="CLU_008523_12_3_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112779" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW11427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="536" mass="58942" checksum="D87E1D461A41A413" modified="2015-04-29" version="1">MKLSLVTLALGLASFVTARRTGSHIGKQLPQPKRNLAPRSAAPAPAHPQLEKRAPEHQFLTNATKKFAVNGSAIPEVDFDVGESYAGLLPISDAKDSPELYWWFFPSTNPAAKNEILIWLNGGPGCSSLEGLLQENGPFLWQYGTFKPVQNVWSWTNLTNVVWVEQPVGTGFSQGTVTATSEEDVASQFLGFFKNFVETFSMQGYTVYIAGESYAGYYVPYIADAMFNANDTEYYNISSILIYDPSLSYDVVQEQLPAAAFANYWADALYLNKTYMESLNNMSDVCGYTSFLEEALTFPPKGPLPSPPNLDLEDDSCDTFDSLFYAISEVNPCFDIYQIFTTCPLLWDVLGFPGSFDYVPDGATIYFNRTDVQKAINAPVQPWAECASDPVFVNNTDLSTPSALSVLPGVIEKADRVIIGHGIIDMVLIFNGSLVAVQNMTFNGAQGFSVPPSQWDDFYVPYHVSYDNQLGTIAGAGVMGQYHTERGLTMVTVQLSGHMVPQYAPSAAYRQLEFLLGRIPDLGTVGPFTTMKDGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZF31</accession>
    <name>A0A0D1ZF31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231778.1">
        <property type="nucleotide sequence ID" value="XM_016385176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZF31"/>
    <dbReference type="STRING" id="91928.A0A0D1ZF31"/>
    <dbReference type="GeneID" id="27337946"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10863"/>
    <dbReference type="HOGENOM" id="CLU_023880_4_0_1"/>
    <dbReference type="OrthoDB" id="4145260at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="486" mass="54145" checksum="1611529225B37A22" modified="2015-04-29" version="1">MVTKEAEIQRASRACRLCRTRKKACDKKLPECGYCIQRGLTCVYGDDSHSTSAEKAAIFVGSVLAMRSSIPIWLAGDLSPSTMQSQSPGLYNSHQGVQDPAMSLAKAVHAQVDHIIRAANISSDYIQERYFRHFHPRLQILEPRLFQEAIEQECGVPAPDVTILLLAMYLITLEPPNDTIYITLRTIFTAVQTSIRTSIALIQASLLISCYEYTHGWLDAAYISVGACVRMGRLIGINRLQGSRDDESLKSDTRETLKLVESWNLWWGITILESALLSEVDENVQKSVSDYHLGDQSPLPLGSESTVGSSMLRCLKCVPLTVSKDNSDFTRLAQATCLLNRVRRAVTFKIDYSELAAIDKEIQSYLLLALNEDRDGCPKALHSISVAIAVRGLFVLHQRILNDVGERQDGYSRNSYAALYTASKMVLDAAKDHYSSSAKPRILFLPLCCRRNIQDAKAFLTDSGEQHCSAVDLQHLRLAEEALNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZGT7</accession>
    <name>A0A0D1ZGT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232393.1">
        <property type="nucleotide sequence ID" value="XM_016383770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZGT7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZGT7"/>
    <dbReference type="GeneID" id="27336536"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09453"/>
    <dbReference type="HOGENOM" id="CLU_028452_3_1_1"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF5">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="44"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="483" mass="52283" checksum="416DC3814272D6B0" modified="2015-04-29" version="1">MDVDAITERQASTADAMANQKRKSVVNQGLTGASALTVRQSIFPVALVTLLFFLWGFAYGLLDVLNAKFQTSLNITAAKAGGLQGAYFGAYFIGPLTYSGYIVRRFGYRVTFMTGLCIYGVGALMFWPSAVYKSFGGFCGSLFIVGSGLSTLETSANPYIATCGPPRLSEFRLELSQSFQAVGSVVAPLLASRVFFKHTHSTDLSHVQWTYVGIAAFVFLLAVVFFFAPLPEVTDADMALQAEQCADLTGYEVKPLRKQYKLFFGVAAQFTYVGAQVAVASQFIRYAQESAGISEAAASDRYAIGQALFAIGRFAAAGLFMFVKPRLVLLVFMTMIMVFIACSMGVEGEGGVAMLSLVLFFESCIFPTIFTLSIRGLGRDTKRGSSWIVAAVSGGALFPALTGLAADNFGSYHLAMCVPLCGFFVSFVFPIYLNVFCRKELDGFRATKIGYKDEGRGTIIGDADDIQTFEAMAKRQSVMVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPB7</accession>
    <name>A0A0D1ZPB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234868.1">
        <property type="nucleotide sequence ID" value="XM_016381766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPB7"/>
    <dbReference type="GeneID" id="27334519"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07436"/>
    <dbReference type="HOGENOM" id="CLU_097999_0_0_1"/>
    <dbReference type="OrthoDB" id="4118178at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="248" mass="27259" checksum="F924FF6E4F0B79AA" modified="2015-04-29" version="1">MSCMSRPVFSDGPRAVQPAYRRASDPESSTTTNRNPVSQQPSCSGDYYHKCYCGCKGCGCHTSPITDEANHHRRNSQKGRAIPIPENPVTVLPWAPSSLSTIHSNDQKFSFDNSFEVGDTYLQAADVAQHEVDSTIEHDEDDDPWTTGQYLSRPDDIELENSSNMIGAEDMEYASMYVEAGGPSSAEDSMLSSQYEASFRRSSGSVTTSQLINGIGDAFASQLPQSAAATMECQHTKTRQMCQVCRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQ53</accession>
    <name>A0A0D1ZQ53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-dehydropantoate 2-reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235138.1">
        <property type="nucleotide sequence ID" value="XM_016382036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQ53"/>
    <dbReference type="STRING" id="91928.A0A0D1ZQ53"/>
    <dbReference type="GeneID" id="27334790"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07707"/>
    <dbReference type="HOGENOM" id="CLU_031468_2_1_1"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="2">
        <location>
            <begin position="203"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="38820" checksum="05F0AC6EC109230D" modified="2015-04-29" version="1">MAEKVRVLLVGSGGIGTMTALNLELGGHAAVSAVLRSNYAAVKEKGFTIDSCDHGKFEGWRPSEILSKVPDVVSDPSAKPFDYIICTTKNIPDVPPVLVDIIRPAVTPGKSVILLIQNGLNIEKPLLKEFPTNILLSGVSFMGADELSPGHVLENDTDRLSVGPFFNPALEIGDQIAAAEHFVKIYSATGKVQCSYDRDVLFIRWRKLLYNAVWNPICAITGMDTTRLRLASEDDDPGSPLNTLVRPAMNEIRAAASAVAGVSLPESLVEVMVDADPLEIWCAPSMMQDTRKKRFIEYEYLVGEALRAGESKGVAMPTLRCIYGFCKAVQWRTKEHHGLVDPQKLMEERKKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZRV4</accession>
    <name>A0A0D1ZRV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235708.1">
        <property type="nucleotide sequence ID" value="XM_016379881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZRV4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZRV4"/>
    <dbReference type="GeneID" id="27332621"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05538"/>
    <dbReference type="HOGENOM" id="CLU_027816_4_2_1"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="92"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW15492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="528" mass="57799" checksum="C141054DB4E4F594" modified="2015-04-29" version="1">MANTDPMSSSSWRGCLMRQSIASYFCGKKEQEKSSEAAVGEASRNESTASSSSNGILSGISPGDELEEKGATEDDPMASHGLKDGVEYKSMAWWQAGMVMVAETISLGILALPNAMSKVGIIPGLILLLCLGAMASYSGYVIGQFKQRFRHIHSMACAGEVLFGKWGGEILGWGQFLFYVFIMGSHILTFSIMMNAITDHGACTILWMVVGTLLSLLCTLPRTLKNLSYYSVASFLSIVGAVMITMIGVSITKPGFIDGRMSVRLWPQPDLSFQDGFQAVNTMVFAYAGHVAFFTFISELRNPNDFPKALAFLQISDISMYIITAVVVYVYAGENVKSPALDSASTVVKKVAYGIAIPTIVIAGVVNGHVGVKYVYVRVLQNKPHDLMHQPLRRHNEVSNKKEFTKLGIRSYGTWVLICTLSWVAAWLIAEVVPVFNDLVGLTSALFASWFTFGLSGMFWMRLNLLQDQDGKLRMVPFNLWTWKTAVLFLINTLNILVAAILCFVGIYASISSMIHNGATKKPFTCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZVP2</accession>
    <name>A0A0D1ZVP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_03977</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237003.1">
        <property type="nucleotide sequence ID" value="XM_016378326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZVP2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZVP2"/>
    <dbReference type="GeneID" id="27331060"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03977"/>
    <dbReference type="HOGENOM" id="CLU_013430_12_1_1"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000013">
        <property type="entry name" value="Cation efflux family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000010">
        <property type="entry name" value="Cation efflux family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="44"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="367"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW16787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="418" mass="44899" checksum="3B43EBA0A545D2C3" modified="2015-04-29" version="1">MSFTQTLTQARSHAGHSHGHGHSHDTAYLTSKNKNDAGVRITRIGLFVNLAMAIGKGIGGYVFHSQALVADGFHALTDLVSDFMTLATISWSLRPATSRFPSGYGKIESLGALGVSSLLLFGGMGIGLNALDALYSQFFLDAAAHAHEHAEHSHGLFSLLGHSHSHGGVPDLNAAWLAGGSILVKEWLYRATIKIARERKSAVLASNAVHHRVDSLTSIVALATIGGAHVFTDASWLDPVGGLLISAMVIRAGWGNTKSALLELADVTVDNEVKSSVRRAATMALKGDAAKGITALPFGDQVEIRDVQGTKSGQNYLIDIELAVPQGFTLQQMEDIEHAVRERTGSKVRGVRRVRVKFVPTEDTRSTLAGDFIPADVSPRSSPEPEDEHHHDHDHGHDHNHHHANGHAHNTSKTKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZW37</accession>
    <name>A0A0D1ZW37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_04092</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237118.1">
        <property type="nucleotide sequence ID" value="XM_016378441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZW37"/>
    <dbReference type="STRING" id="91928.A0A0D1ZW37"/>
    <dbReference type="GeneID" id="27331175"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04092"/>
    <dbReference type="HOGENOM" id="CLU_019266_0_1_1"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="86"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW16902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="534" mass="60116" checksum="7B22BC79E9A5B84B" modified="2015-04-29" version="1">MDKEKDRPDAGLRDLDHYKIKLPKWRYSLREQLLPIVRWETPYVAWLQESLRTPALDTYFAFSANLGTHTAFMVLLPILFWCGHTSVGRGMVHVLAAGVFFTGFIKDMLCLPRPLSPPLQRITMSGSAALEYGFPSTHSTNSVSVAIYSLYLLHGNDQMNPNTKLGLQILFYLYAFSIVLGRLYCGMHGFFDVVWGTFIGAVLAWVQCRWGESFDEWLHTGDIQRLFFVILVVLVLVRIHPEPADDCPCFDDSVSFAGVFIGCQYGVWHFAQTSYAWAEPSPGTVPFDLTKMGWGVVVMRIGLGVLTIFAWRGIMKPTLLRIFPPIFRVIEHLGLTLPRRFFKPASEYEKVPKQRNDDNVIPPARDIPHLLSSFRRRRAISVGPQSEADAYEALAYRNKRRRDSRILEGPPSPATQASPEPNSFQDDNPAQKSSPASGRQRSSSLETFRAQMGAGVDQLSPMLLTTPGGHGSPSPQEVQAMDLLQERRLFASIQRPRVRYDVEVVTKLIVYSGIAWLSVEGNPILFKHLGLAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWK8</accession>
    <name>A0A0D1ZWK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237273.1">
        <property type="nucleotide sequence ID" value="XM_016378596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWK8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZWK8"/>
    <dbReference type="GeneID" id="27331331"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04248"/>
    <dbReference type="HOGENOM" id="CLU_464623_0_0_1"/>
    <dbReference type="OrthoDB" id="4159521at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="565" mass="64535" checksum="7F8366B38CC54054" modified="2015-04-29" version="1">MAGSSRPRPGSSLFAIFHPEMDGYLHVGKIASGDRSSTTLVQSVADGRVCVRKNVLATHAFGADGTCQEVEFYRQYSHPQIPRLLHAQANRMFADGALIGAQYKGTSLLFEVCNGHTMERLADMEKFKPSTLFLWRTFDQLLGAFSFLHRNDLVHTNAHLGNIFLHFPDEDARLPDVVLGGLGSVTPLSPDIWKDSDRTELKDDCDEQSVRPLLEDLAWIRSAMADLLSLSDPTVAAEDANEEEDEEDALDVVEVLREVLEDTIQKNIAWGKHGREMYQLWWRFDEVIQGMLEKGMHWYQELRKIQKEVTRVRLREDRRLPSDKAQDMRPLMRTVDKPNPCFSVDDAEPYLFSSRTELESYVESEQIQGPYRIARIDAGNSKRILNIDKFDHGYFHAGTWHMDVPVFSQHLLPILQERQKYDWRSWPDVVRLADKLLDGIVVPKQSFCPFGRRLETLPGPVDEETVNKFFTPDPEWHTRHTYSRSETYEILYSSTLNSLVGSLSIHDDHDDDDDDDDDDDDDDDGDAMSISTENSRVTGTVAGMKRKRTATDEGNELPSGKRREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZY41</accession>
    <name>A0A0D1ZY41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_04726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237748.1">
        <property type="nucleotide sequence ID" value="XM_016379071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZY41"/>
    <dbReference type="STRING" id="91928.A0A0D1ZY41"/>
    <dbReference type="GeneID" id="27331809"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04726"/>
    <dbReference type="HOGENOM" id="CLU_012774_2_0_1"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="184"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW17532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="599" mass="65924" checksum="BB4008514BB38D10" modified="2015-04-29" version="1">MAASVLGKRSRRLIDEEDISSLSPVPKRRTRRSAPQIYEDTDGKKHLGEQPSPSKHQSPVQTRSVRHRIEKPKRIEPDSLVDSKTTAIEIQDENTTPAALSTPTTTTRFKNALATPPCTPKHRVRLGARFLTPRSARTSTHSRQNVYSQARQLFTQASNGKVIGREPERKRLTEFITKALETKKGGCTYVSGPPGTGKSALIQEIMQDFQEKNVKLATINCVAFKSSNEVLTSFAQEFGCGGGNQKATKASLSRLFTAQKGSSDMHLVLLDEVDTLLSGECEVLYNIFEWAMHPTSSLILIGIANALDLTDRFLPRLKVKNLKPELLPFLPYDAQQISKILSEKLRTLLPADSTAPPDFIPLIHPAAVQLSSKRIASQTGDLRKAFSLIRRVIDKIEQETLAKLSSSQTTPTKQPLVEVGNLQKTIESRSVLSQLTIETAPRASPAHVAAVASSIFNNTTVSRLSGLNLQQRAVLCSLVASESRQRHCDPYTTPSKSQSRIPTIKALFERYTALCKRDGTLVPLKVTEFRDVVASLETLGLVHESSGRTSSLLTPTKTPSRSGRALDDKQVLSAVSEKEMRDSLSGPGADLLLKLFEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYH2</accession>
    <name>A0A0D1ZYH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_04902</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237923.1">
        <property type="nucleotide sequence ID" value="XM_016379246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYH2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZYH2"/>
    <dbReference type="GeneID" id="27331985"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04902"/>
    <dbReference type="HOGENOM" id="CLU_002458_0_0_1"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="9">
        <location>
            <begin position="24"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="10">
        <location>
            <begin position="210"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="419"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW17707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="803" mass="91796" checksum="A94D3024F0143634" modified="2015-04-29" version="1">MSLHASKDASWNDQFKDINQRNIKVQIFISVGLGLSAFLSFCVLRPKWTSLYHARKKQSDAASRLPDLPKTLFGWIPVLYKISQEEVLASAGLDAYAFLSFFRYAIKYLCVTLFFSLTVILPVNYRFTGQPLFPNPINGTDPDAGSVMMFRIDPQKPKKGVIEKDNSYLWMYTVFVYFYSFVAIYLLIQETKNIIRIRQAYLGTQATITDRTLRLSGIPSEMRSEQAIKYFIEDLGIGKVDSVMLCRNWQTLDSLMFQRMKCLRKLEEAWTVYLGHHHSLRHSRARHQQRIRLGDADEDGALLSRSEMEQAHVMPADRPRPTVSLRYGPLNIYRRKIDAIDYYEEKLRMLDERIHTLRTAEFKPMPLAFVTMESTAACQMAIQAILDPEPGQLLASLAPPPADVVWKNTYLSRNHRMIRSWSIMIFIGLLTIFWAAAVAPLAGLLSIEVIDKVLPGLAAALEEHEIIRSLVQTGLPTLLFSLLALAVPYLYDWLSNQQGMTSQGDVELSVISKNFFFTFFNLFIVFTIWGSATNFYEFWQDLQDILRDTAGIAYAVAKALEQLSPFYINLIILQGLGLFPFRLLEVGSVALYPFYLIGAKTPRDYAELARPPVFSYGFFLPQTMLIFIICIVYSVLPSSWLITLFGLVYFCIGGFIHKYQLLYAMEHRQHSTGQAWPMICNRIITGLVLFQVAMTATLALRGALTASLVLAPILVITIWFTLYFQRTYVPLMKFIALRSIDRQNLLDFPTPSETPWDRDTDYGRTVDTDPNTGLRYINPNLVQPLETLWIRKPGHGIPQSDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYH5</accession>
    <name>A0A0D1ZYH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016379251.1"/>
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    <dbReference type="STRING" id="91928.A0A0D1ZYH5"/>
    <dbReference type="GeneID" id="27331990"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04907"/>
    <dbReference type="HOGENOM" id="CLU_091064_0_0_1"/>
    <dbReference type="OrthoDB" id="4130940at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="267" mass="30541" checksum="23B4D993772360D9" modified="2015-04-29" version="1">MSLCLVLPRHRFGSSRFNTVVLLFLRLFYHAGPFETVAPTTTAVPTQSSAPSAQAPNATDADEPSGLGCVGQPEGFNSYRKFSTQEWLRHLSNVPENLTDWKVCSITWIKALASPFSHEFLQFVVQDVKSGQRTRLAAGREEDGDWVLVGWNWASGETPSDHYKLPLPLLSLEFDGHEKMPSMHALADVLAATTRRRPHYRFRREMCWWYAETVLEEMSAKYGGSVTEWPWSRYRYSFVVKTSFIRRHTLTQHAEAFKTRLAAEMTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYS3</accession>
    <name>A0A0D1ZYS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238033.1">
        <property type="nucleotide sequence ID" value="XM_016379356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYS3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZYS3"/>
    <dbReference type="GeneID" id="27332095"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05012"/>
    <dbReference type="HOGENOM" id="CLU_034111_0_0_1"/>
    <dbReference type="OrthoDB" id="4160292at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="572" mass="61566" checksum="9E48655A4798A95E" modified="2015-04-29" version="1">MARRKRTPSDPASSDASQKRVAFEVPASLEHLSTISRALATSTDPGRQAASPGHSQPRQPQPGLTSSQSSSVAPASLLATNRVNPTKQIQFIVQNRPFPDAQPWPQPMPQTQSYNATSTHSARPTNQHYSRPLPSTSEVTPSAVAPANPQSFNASKPGSATSSTQEPALKPGETPSLTTHPNLIASLVARKRAENEARGFREIWAKRQAEYKMSKSAQSSPQNGLKAVESVAQQNPPDTASKSPSTRSAPMLSRASAPIKAVVDTAAATDNRVSAPATGDSKMDKGVPERRRTESDSSFSPTFPSPATGAPEKPANTVGLKGTSKSTSTSNKRYMNNPPVPQSHEHQRSLPTAPTSTQTNTSVEHAPIPPLFSDKGFRDQSQSQPQNHMSEVGQMDPTYKYSPDVTQQHAYPRIPISRQNSQSQLKAYGAQPQISSQPPVTASNPYYARSPSMSEYYKMDMQTQFYSSDQNSNTQSNSNGFDVAEVYGRSSTPMHMTYTGHLAQNPNAYMASMPPATGPLSSYGASMASPTEQPKLQSQSTNTMMTAADMVAGINTKFKVATQDGFAVPRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A1X1</accession>
    <name>A0A0D2A1X1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="14" type="ORF">PV08_03226</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239153.1">
        <property type="nucleotide sequence ID" value="XM_016377583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A1X1"/>
    <dbReference type="STRING" id="91928.A0A0D2A1X1"/>
    <dbReference type="GeneID" id="27330309"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03226"/>
    <dbReference type="HOGENOM" id="CLU_029061_1_1_1"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023268672" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023268673" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="510"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="111"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="509"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW18937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="564" mass="61771" checksum="7A4F578C5C286AF8" modified="2015-04-29" version="1">MATVTASNVGRACLYRRSPSVISSTLVRPLSEPLPSSRPSPYRVQLRVQPRRSFGHTPRRCRENRQKSDEESFSSRLGKAWRSTRTEWKPIPIGLGIGFLGLFQLIRIRNREGGASEGSGETDGKRPPKRQRIYPTGGGWQVSIMSTLPLKAISRVWGRFNELTIPYYLRVPGFKLYGRIFGVNFDEIAEPDLHAYPNLASFFYRELKPGVRPLDPNPNAVLSPADAKVLQFGTIENGEVEQVKGMTYSVDALLGQIAPTTPNPQHPSAIFANPSTKDQSTPEDDPDLESKSIRADEEFANVNGISYTLPSLLSGSSRSSPDGDGAKTQDASTKSLPSSEAAVSADLATTSPWWSPFSSPSTNKKLYYVVVYLAPGDYHRFHSPVSWVCSARRHFAGELYSVSPYVQRMLPGLFTLNERVVLLGRWKHGFFSYTPVGATNVGSIVINFDKELRTNSLTTDTESDRQAAAAAARGEPYSGFSEATYEKASKILGGHALRRGEEMGGFKLGSSIVLVFEAPAGHRKSSLNEGGAVGGDLKGGFRWAIERDQKVKVGQALGYVVDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A581</accession>
    <name>A0A0D2A581_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240158.1">
        <property type="nucleotide sequence ID" value="XM_016374882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A581"/>
    <dbReference type="GeneID" id="27327600"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00517"/>
    <dbReference type="HOGENOM" id="CLU_1421433_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="191" mass="21402" checksum="9192B038E3B25B08" modified="2015-04-29" version="1">MPLARVYNHVETVDRPWPGGRDLGPAQPWILRRRRRRSMWVDDGSPEPPLQRRPYNPFGAARDVPPPDGGGGEGDDGRGRDDPARDDEQQPPPQPAGDNNRPQARGRQGGEEWFFPRDLMRERRGDRRPPPLVLEPYPGIQPTPHLVGCVAMEQKPEPQPTTDDHRAHVRVHVLGVVAGEHEGPHGRSLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5D6</accession>
    <name>A0A0D2A5D6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240193.1">
        <property type="nucleotide sequence ID" value="XM_016374917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5D6"/>
    <dbReference type="STRING" id="91928.A0A0D2A5D6"/>
    <dbReference type="GeneID" id="27327635"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00552"/>
    <dbReference type="HOGENOM" id="CLU_490922_0_0_1"/>
    <dbReference type="OrthoDB" id="3439209at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="61548" checksum="193970E21966CF51" modified="2015-04-29" version="1">MSREPFDPLVTDDYPGEYAPTNDSSHPVGIPSDSADFKQFTNSRASVAERFVPAPYDTCCQCHRHEVAPSQAQEGSRHRTFYENGHSLQATSLDTMSPSVLPASDYFLNASFIPRDWSSSSHTLGETSGMLSGTASLPPPCQPGIENGLFDHNGENTMRSSAVNRFLSTVDDAHCSNALLSADLDIHPIGTVPLFATSSPPTRQSNIAEPYLHTFEGDDGTVQDPFRYPDCENVVLPTLGLGVDALDGHDHLQYDVQTSSFGKMATPEVFLENTDTTLVSAAAVNHLVRNSRNQQSVSLSVPSFHPSSLYAECSFQRPSSEDVELQNPSKFQQLEAVPMLEYPPLPELDDYAYQELEQADSTNHGPHDDLHHQWYMEEQDHIAGLPEVPPSILHNNHTLRAAPRSEFHTSTTSRQVGSRSGQRDTSKDDLLVHLKSQGMSYKQIKEIGGFSEAESTLRGRYRALTKPKEARLRRPEWGDREIELLFEGVAYCSNTDPLASSSLHNLDAISIGQFVNKVPWKQVAEYMEGKGTYRYGNATVKKKYLEILKLRGTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5M6</accession>
    <name>A0A0D2A5M6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240278.1">
        <property type="nucleotide sequence ID" value="XM_016375002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5M6"/>
    <dbReference type="GeneID" id="27327720"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00637"/>
    <dbReference type="HOGENOM" id="CLU_1525170_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="176" mass="19156" checksum="12FF86992C6682B7" modified="2015-04-29" version="1">MALTTDPTPATTTLTATAKKDNQASMLLLSSSSSPNTTSLSTALVLKGSSKPCECPTKPQPPSTSTTLRTNAVTVHPARKPSRLSKYNHELEPIWEEPEDFSYHARTTADKINNGFKDTDERKVSNGSINNNINDRSNSRSSSQGSHLAFATSTGQRLTQRPAASKPSLWRRILPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7Y7</accession>
    <name>A0A0D2A7Y7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_01476</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241113.1">
        <property type="nucleotide sequence ID" value="XM_016375837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A7Y7"/>
    <dbReference type="STRING" id="91928.A0A0D2A7Y7"/>
    <dbReference type="GeneID" id="27328559"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01476"/>
    <dbReference type="HOGENOM" id="CLU_005431_1_0_1"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="452"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="689"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="579"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="915"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="938"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW20897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="949" mass="106376" checksum="F9AE51B6400B2715" modified="2015-04-29" version="1">MDNRSTRYRSPEAKSAVPPTRNRDRHNSAPTSDRRKDQHSRHVPSAKSISDGTQRTHKPSPRQDSLMSPDKRATARHADQRPANDHSSQSNLASQLGHSSTLSFNFLVLGAEKCGKSAFIKTAIDQEGSRTSTQVTIKDQSYHIRFIELSLDDVDFSSERRIEWPTSVNGAPFPEVHGVFCLYSVSDKESVADVPTALTSMTKTGLPCMLVASKSDTKQESRQINPLFLEQVKRNLASVAIAEVSLKTPQSIKLCFLNMLNRVIGSPRAPARTSKPQTVSSQSTTQRTGLRDSSPKKPRSRSRSKTRLQTSKSKEFLLNMSVRAAVIESANEDIESSSAEEVTSPTRKTKLQLDTAAASKPQRRRQEPHTPVSSGEWTNKLMSPEQTTTATVPETPESYYVKSMLRPASPDHVESKAYRTFLNMDEESNEMPSRGDVDQLGPPLNANKPDDSSKQELGVPFKELVEKLLILPANKTDSKFVPSFLCLYRAFATPKQLLVAIIDQFVAIEKSNMVHFSKVAEMLRYLQVLAQWTATYPGDFAQGPARDKAIPFVQTIEKSKVFAPAAREISNNLDTLVPDDDADWAYTDPPKKTPSSSATSLPLLNVDGTKADRKSPHDSDSDDDNNDSPAPSNTPSTSSSMTRPYNTSSQSASNVVQLENAKLQADHLKKSIPHIRLGKLQWHQFMEIPVEELAREITRIDWTMYSAIRPRDFVRHVSLSAEQKRRYRGTDNISAMVKHFNHLALFVSGMILLRDKPKHRAKALEKFMELAWKVRQLNNYNSLGAIVAGITGHEIARLNSTRELVSPESLKSFMRLTILMGLSRSHAAYRMAWENSFAERIPFLPLIRQDLTMAASANPTFIGDNVNWKKFEIMGEVIVGIQKSLETPYSFPPKTVRTEETVKLLLETRIVDEPEDSADPRSELYDRSIQVEPQHTGADPRKKFDWLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8Q8</accession>
    <name>A0A0D2A8Q8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241378.1">
        <property type="nucleotide sequence ID" value="XM_016376102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8Q8"/>
    <dbReference type="STRING" id="91928.A0A0D2A8Q8"/>
    <dbReference type="GeneID" id="27328825"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01742"/>
    <dbReference type="HOGENOM" id="CLU_049915_0_0_1"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="65"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="212"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="325" mass="37015" checksum="08F91B4E03C44C58" modified="2015-04-29" version="1">MNDILLSPALEDQVTSKFDELVAKGEIIYEPSTADIKEDEGFKVCCRHYMSGLPSRRQILTWYPGAQFQFRLVPHLVRKPITAHDAPERKTGRGNNPFLNPDPNFTLSEVGSFHLLLLNKYCVYRPSLLLITRHFAPQSDSLDAHDLSAAWSLLNRFEKKYMMIFNCGYEAGSSQGHKHMQLWHYPDEREMGFPLFPSKAVSTTEITSDIEDVPHQHFVLRLPSKVDETVLVKAYGRLHKAVEDCHARYGGGPAYNVILVREWMCLIPRRHCGLERGAGANAAAIVGTVWVISETEKEIWNAEYFRYLGYPREARPVGLVHQSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8R3</accession>
    <name>A0A0D2A8R3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241383.1">
        <property type="nucleotide sequence ID" value="XM_016376107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8R3"/>
    <dbReference type="STRING" id="91928.A0A0D2A8R3"/>
    <dbReference type="GeneID" id="27328830"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01747"/>
    <dbReference type="HOGENOM" id="CLU_686959_0_0_1"/>
    <dbReference type="OrthoDB" id="5409998at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="387" mass="41989" checksum="29DAB586B81C00EE" modified="2015-04-29" version="1">MAVTKPAYDPLRIVEGMFNGSVTRIAYAMKDPVNYAQSTRAVLVETAKKFQDALDDCEVQILDAKWYLENKLAQNRARREAKAKEDSAATAKRKRDEVEGAQEKTQEAEQETASKRVKTAEPDTSVQTQPQPPPPPKPKDSPPKPSKAPAKPQTSPKIAKKTAPAKPAEKQVAPTKPDNKKSQSPSIPAVKAPAKMPEKPFENPPPPVSEPKPTPLNFDDFAKATPQDMSAGGNEDFNFTSMFGEPSTDMMTGSGNDMNFDMNNLGDGFDASVSQDTSLNSLLPGLESYANQAGDDTFNMPPTDNNVSSSGNAPADASQPAPLNPNDFSLPALGPNEFDELLNSSDMNFDDAVNFDSTGMMNMDNMDSMDNMESMENMDLDFDSMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A9V2</accession>
    <name>A0A0D2A9V2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="17">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PV08_02082</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="17"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241718.1">
        <property type="nucleotide sequence ID" value="XM_016376442.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2A9V2"/>
    <dbReference type="GeneID" id="27329165"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02082"/>
    <dbReference type="HOGENOM" id="CLU_000846_5_2_1"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000172">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1335"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1368"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1397"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1441"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="227"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="338"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="1222"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="635"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="914"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1556"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="14">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="761"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="808"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="831"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KIW21502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1603" mass="179206" checksum="D0619A88CCDE2FC8" modified="2015-04-29" version="1">MAVTPPSPPGDQELNRNAPDSPRAGQSNSENAHGAQDSEGELVGTIHNETSRVRFSVELPRSGVEGKAQKDPTVSAQKPASVLKAPSYGRSRGYSLRRSLFAQNIQRQNEDHGASFELGTSDSSLDSRKSKESGHLQYTSITIQETGEESQLAAKSPARLSDPNLDLPLYRRWLSKQSSRVTLWQKARNTYQQARDRIAKANTIPPSVDGRHVRVRVLQLDSPLDERTGKPYIDNLIRSCRYTPWNFVPRQLVAQFGKLANFYFLCVSILQMIPGLSTTGTYTTIVPLLIFVAISMAKEGYDDVRRHRLDKEENERLTKVLHMGNFSQEDGFQAGALEWHEKRWHQVQVGDIVLLTRDCPVPADMVLLHANESSGTAYVETKSLDGETNLKSKKPLADISEACQDTDGIANLSAEFVVEDPNLDLYKFDGRVDMNGRSFPLTNNEVLYRGSVLRNTSSATGIVIYSGEECKIRMNATKNPRVKAPALQAKVNRVVVIVAALVIFMAIILTVAYTIWQKTTEEDSWYLQSAKVPFGHILTSFIIMLNTMLPLSLYVSLEIVKVAQMFLMNDIDMYDPETDTPMEAHTSTINEELGQVSYIFSDKTGTLTNNSMKFRKMTIAGTAWLHDLDLHEDAVGDGGREKLRHKKRGGKGKEISGRKSKQSHAKSTRKSAASATVEKEALSAEVEDRSESLPWKASSGLDMSMETGNTQDLLDYIHHRPQTVFARKTRFFLLSLALCHTCIPEKNDAGDITFQAASPDELALVTAAQDLGYIVTNRDSHTVTIKTYPDNDEDPIYETYEVLDVIEFSSTRKRMSVVVRFPDQRICLISKGADSTLRKLLRLADLASSSVQAAEGRATQRKSVEAQEALRRKSVALSHRSNSVHVADSSPRVSGLTIDKSRTARESIDQWLKEREADPGISRPRRSSQFYSPRPSVQFGSRASETFGSRAQFSSQISPRPSMQVEGVEELVEESLVINEKAVFERCFQHIDDFATEGLRTLLYGFRFLTEDEYSTWREIYESASTSIVDRQSKIEQAAELLETKFELLGATAIEDKLQNGVPDAIDRFRRAGIKLWMLTGDKRETAINIGHSCRLIKDYSTIVVLDHEAGDLHSRMASGFAEIDDEKTAHSVLVIDGQTLTIIEADRASMALFADLAIRADSVICCRASPSQKASLVKTIRTKVKGSVTLAIGDGANDIAMIQEAHLGIGIAGKEGLQAAKTSDYSIGQFRFLLKLVLVHGRWNYVRICKYVLGTFWKEMLFYLVQAIYQRWTGYTGTSLYEPWSLSMFNTLFTSLPVIFMGVFEKDLAASTLLAVPELYNIGQRDRGFNVKLYVWWAGLAACEAVIVYFIMYSIYGMALFTRDQGLYAMGSIAYSGCVVIISLKLQCIELHNKSVAAAIAIFLSVGGWWLWNLILGVIYPQDVIYSVRHGFLDRFGRNLLWWLTLLLVILCVCLLELIIKTIKVAVWPSDVDVFQGFEQDREVRKRFEEAAADLLQQGWDRGTKKSSLELAREEAEQADREAQVQALLDRPRDMNRRKPFVREVSSTSTMQVAKSGQVLPKGGGDGGGQEMEEVPRKSLDAGELFTKGFGAVRRETMQELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASI9</accession>
    <name>A0A0D2ASI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_12065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847505">
        <property type="protein sequence ID" value="KIW09678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229894.1">
        <property type="nucleotide sequence ID" value="XM_016386372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASI9"/>
    <dbReference type="GeneID" id="27339148"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12065"/>
    <dbReference type="HOGENOM" id="CLU_011910_2_0_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="206"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="575" mass="64793" checksum="B09E746DCDBCF1E0" modified="2015-04-29" version="1">MGELSRKVSLAQGEGAFGLVGNMSEVAWIDQAFGVVRGRPGATRPRLSTSGVLDPHAFSATNFIYFVDDDEVLTVNEDPIDPYQRPSFSRSLVLTEAYFHALQDAFPFVVHDDFLSNLFNVSTQHSWTGRRLLAKANMMWAIGSKWLEMTGMNGEAPRDTHQHYYARARALGLDHRAVFDHPNIDQVQGMGLLVLYLLFNGSVTRAWITLGCATRHATALGLHLRVTDPSVSDEDLRSRARTWYSLYSLEVLISEITGRPKSMSVSDVTVPIDLLERGNLDYSPPSPVTSQIGDSILLEISRKTWLEHLDLMQNTSSLEVKVGELGQEAASPDYAIPNAYLPQRLCLCLLSDKIARQLYSGTNDDTWVGLQRKIHGLEDEMQHWFENLPENLYLVSRGRQSRNLRARIELAMYYRSLQMILYRPCLCANSVEVEAVESREFNHRSARACVLGAMSMLALLPDDPTITEIYRRLPWWSLLHFVAQASAVLHLELAIDAQHFEGEVNQLVESVTKAMQYLHCMAGASLSAYRAWNIFRTLLTEVSRRYHNMDLSGVAQDAPRPPGWTEELDKVVSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AV74</accession>
    <name>A0A0D2AV74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230591.1">
        <property type="nucleotide sequence ID" value="XM_016385647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AV74"/>
    <dbReference type="STRING" id="91928.A0A0D2AV74"/>
    <dbReference type="GeneID" id="27338420"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11337"/>
    <dbReference type="HOGENOM" id="CLU_694518_0_0_1"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW10375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="397" mass="44965" checksum="64BD274574BEED64" modified="2015-04-29" version="1">MAAVNIDMTDRCESDEHITHTVDQFLSKRPRRSYPKACHPCRRRKVRCNNAQPCSNCISRDYPELCYYAFTEAERGSLRQRRRRNGAALWETNGKDQVTARRSSRLLEFERELHILERTAFTEAAPSVKAKDGHRSFSDSVAKSYERATHRKVSSAATTMKPETEHPPHQQLDERCVRTPTVSDTPYMADAGNIHPFENLWQPGSSVREVAMALPSDEIFTRYLEAFYEVYQVAMPCGPMLELREDARRFWRARSLGNYVGPELQSTSWLALLFSCLAFGSCFADPSSEDTQLNANIFVCCAFQLLRLDNYLLAPKIEHILALSTLGGCLRGQANPDASWSLLGTTIRLAQRLGLHQQAALSASSTPSEKYAWHLWYVRLSIILMNLVVLASARPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVR0</accession>
    <name>A0A0D2AVR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF985 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231044.1">
        <property type="nucleotide sequence ID" value="XM_016384442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVR0"/>
    <dbReference type="GeneID" id="27337210"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10127"/>
    <dbReference type="HOGENOM" id="CLU_097615_0_0_1"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="1">
        <location>
            <begin position="27"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="244" mass="27041" checksum="0DFA966DB996A607" modified="2015-04-29" version="1">MMIPPSDTDYARALLAHPPSSDPAAVQHTISALSLQAHIEGGFFAETDRDKLLVPNPFQNLPLLANATSRQKKDLDTSATRSASTTIFYLVAPTSPVGYFHRNRARTVHTLHRGRGRYVILHVDRRDDQGRVPVESFVVGQDVERGEKLQWIVEGGKFKASFLLPDTAAAAAATTTEAAETGVSEKGLLISETVVPGFEYSDHDFLTAEGMVEYLDPKEIEELRWLLKRGEQDRLDEALKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXF7</accession>
    <name>A0A0D2AXF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADPH-dependent FMN reductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231331.1">
        <property type="nucleotide sequence ID" value="XM_016384729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXF7"/>
    <dbReference type="STRING" id="91928.A0A0D2AXF7"/>
    <dbReference type="GeneID" id="27337498"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10415"/>
    <dbReference type="HOGENOM" id="CLU_055322_2_0_1"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="251" mass="27931" checksum="9083653960987928" modified="2015-04-29" version="1">MAKSVAKVAVVICSNRKPRANPQIANFVLEAIESTYQDRWSLEPSFKVIDLAERNLPFFDEPDVPSQIHDYTKYAHAHTREWSQEVQSYDAFIFVCPQYNWGYPAVLKNAIDYLYNEWKGKPAMIVSYGGHGGGRAAGQLRQVLCGVHMIPTKKHVELAFPSRSVLLEAAYGKDLGLDGFNAKGTWASQRKEIGDVFAEMMDLLTSNKVGKALKSAAVTFGYAKEELRKKFKKGSTAGEATGRGEARSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYM8</accession>
    <name>A0A0D2AYM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231706.1">
        <property type="nucleotide sequence ID" value="XM_016385104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYM8"/>
    <dbReference type="STRING" id="91928.A0A0D2AYM8"/>
    <dbReference type="GeneID" id="27337873"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10790"/>
    <dbReference type="HOGENOM" id="CLU_780825_0_0_1"/>
    <dbReference type="OrthoDB" id="4160849at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="355" mass="39945" checksum="B8FEE54ECA3F9390" modified="2015-04-29" version="1">MALHGRLTFLFDDKFDYEFEIIMKQLPALSDYEVALEMRSLMKRPDVVERAKQMLQVRPGVVNVFLDGRYLIHDALNQTSCSDAFWVSELLKYGADPNARSNSGDTAVSWACKLCRNNGSAYLQALQSLVQAGGDINFLNDQKPVGEGQTPLILAVNTSRLWSEDKLRPDEDDKRAFDLVDACIGLGADVNATDTSGRTALHWAAMCGNVVVVKRLLDAGADPELKDSKQRGVLDWWTHQRNKATFKLLKERMNPRNFAAKTVKTSTEDGDSEIDSEDEVDQRNELSKYFPNVPKAPGAALAQPPRQGPTTLSEEQDRLVKKLMWWSNTLQWSRETCIEGLERCNWDFNSVKCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZI4</accession>
    <name>A0A0D2AZI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232081.1">
        <property type="nucleotide sequence ID" value="XM_016383458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZI4"/>
    <dbReference type="STRING" id="91928.A0A0D2AZI4"/>
    <dbReference type="GeneID" id="27336221"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09138"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34989" checksum="F52F6DD04707F68B" modified="2015-04-29" version="1">MMEFGWGTTGNEVVHQFKDRVTGKTFLITGPTPGGVGAESAKSLATGNPKHLILAGRSPSKIQPLIDELNANYPNVKVSFVPLDLSNLDSVRAAAADVKTLLAGDKIEVVILNAAVMACPYALTGQGVELQFATNHLGHFLFCNLLLEADLIRARVVVVSSLASQRKASLLMPHLKDLSYDQGKTYDPTTAYSVSKACNILYAKRLAKVLAPKGISVFSLNPGSIATNLQAYITNEMRQRAIEQFKIENPGFQPPERKNLQQGCSTQLRAALDPTLEPNSGAYLDNCQVLETDEHKDAEAYIDEVWTLSEKLVGKRFDFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4P4</accession>
    <name>A0A0D2B4P4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233886.1">
        <property type="nucleotide sequence ID" value="XM_016383183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4P4"/>
    <dbReference type="STRING" id="91928.A0A0D2B4P4"/>
    <dbReference type="GeneID" id="27335944"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08861"/>
    <dbReference type="HOGENOM" id="CLU_000288_138_13_1"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="552" mass="63194" checksum="6C054388FB9C36C7" modified="2015-04-29" version="1">MWLLNARTYRIKHFTIPPPYAILSHQWGDEEDEISFADIRRTREESQARVRRKAGWRKLQGCCEQALKDGLEYVWIDTCCINKESSAKLTEAINSMYRWYKNSVVCYAFLYDFAAPEGIDKMLKSRWFSRGWTLQELIAPQDVFFYDRDWHYFDCRSDRFSEISLATHISMGLLGGFESIDDYSVAVKMSWAYGRQTTREEDVAYCLMGLFDVNMPLLYGEGRKAFIRLQEEIIKNADDQTILLWDPLPPDRTRISGILAPEPSCFGRTFAFDIINYKTEPFQMTNKGLSLTTRLSPYNDDIYVAWLQCGTASAAIGIFLRRLAKGDRFARAYPHGSSTCIEGGSISTSFSDKRHIFVAKEIPASREASTWMYTLSSHCSEKILLNTVWYPSRYEIDLMDALKHESEAAFGSNLVAHWNLNRACLWMVYGFDFDLNPVCVFYRKSVCSHTFGEILGGGAPFKILGDIKDDVCLSWKEFVAASDSGRLDMDLLREGVLALKDITQRGLHVKLTFGRECEPRHLSVRVRLESSPHLFFGFKNLPSVDNPGPNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5H5</accession>
    <name>A0A0D2B5H5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234384.1">
        <property type="nucleotide sequence ID" value="XM_016381282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5H5"/>
    <dbReference type="STRING" id="91928.A0A0D2B5H5"/>
    <dbReference type="GeneID" id="27334032"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06949"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW14168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="350" mass="37818" checksum="1F4852F01D966B81" modified="2015-04-29" version="1">MDDPHNPYAAAHKRPRGAGDARPTALQIIKDNDRLSKLSDLVILITGCSSGLGVETARALAATGATLYLTARNVPKAREALGPEILSNSQVHLLELDLDSLTSVRSCASAFLAQSSKLNILITNAGIRHVPYAKTKDGFERHLGVNHLAHFLLTYLLLPTLQASSTMAFQSRVVALSSTAHRHSDIHFDDINLAKPEAYTPPTGYAQSKLANVYMATEITRRYGSPKAALGQPGVWGLAVHPGGIRTGLQAASGGLREVLNWYYARNFMKLINYIKSTEQGAATTVLAAVGERFEGRGAMYLEDCGEAVPVKPGWGLIDPGYVPGRTDNEEDARRCWALSCKLLKVEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5P0</accession>
    <name>A0A0D2B5P0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_07035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="4"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234469.1">
        <property type="nucleotide sequence ID" value="XM_016381367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5P0"/>
    <dbReference type="STRING" id="91928.A0A0D2B5P0"/>
    <dbReference type="GeneID" id="27334118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07035"/>
    <dbReference type="HOGENOM" id="CLU_049611_0_1_1"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW14253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="319" mass="34997" checksum="10901DCDFEB798FE" modified="2015-04-29" version="1">MKVVILSDSQAAAANIAQHIIDRINSFAPTDTRPYFVLGLPTGSSPLPIYRLLVDAYRVGTVSFRNVVTFNMDEYVDLEQTHPESYHSFMFTNFFNHVDVQPQNINILNGNAADLDEECARYEDKIQAAGGIDLFLGGVGRDGHIAFNEPGSSLVSRTRVEVLAQDTIHANARFFGGDLSLVPTRALTVGVQTVMDAREVVIIATGAQKASAVRNAIEGGVSQMCTLSCLQLHPNGIVVVDEDAALELKYATVKYFKSLGDLSTLNISKHQRHSVLPRTKLCATPPQTPDSKSYLEDDELTPDRMSSRIMTWPLAARPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5V4</accession>
    <name>A0A0D2B5V4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_07085</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234519.1">
        <property type="nucleotide sequence ID" value="XM_016381417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5V4"/>
    <dbReference type="STRING" id="91928.A0A0D2B5V4"/>
    <dbReference type="GeneID" id="27334168"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07085"/>
    <dbReference type="HOGENOM" id="CLU_012773_0_0_1"/>
    <dbReference type="OrthoDB" id="5321960at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF46">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="634"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="758"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="800"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="860"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW14303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="873" mass="98699" checksum="01EFC5AD32900CAD" modified="2015-04-29" version="1">MLDQAFESITDPWSIPDILCLALSAPLVLLAFFESFLWVAAFCYCLGKAYQKADHWSQRFMAVVMTLCFVIVRGIFFPIMVVTLPLPHRVTQYFPGKMAHVFQQFAFYSFAVMLMVPWLFCVYRSFILPLGRDKMIKSPLNDLNAPKVVVVMPTYKEPPDSLWKALNSVVKCDYPASSIHVFLSFDGDEVDELYLKTIDRLGIPITMEDFPQSIDVAYNGARVTVSRFPHGGKRHCQKATFLLIDKMYKRYLLHKDDMFILFIDSDCVLDPFCIQNFMYDMELRPGNKRNMLAMTGIITACTEKNSLLTILQDIEYLHGQLFERSVESGCGAVTCLPGALTILRFSAFRNMAKFYFSDKAEECDDLFDYAKTHLGEDRWLTHLFMLGAKKRYQIQLSTTAFCKTEAVQTYRSLLKQRRRWFLGFITNEVCMLTDVRLWRQYPCLCALRFMTMTIRTTALLMLIELVAVATTSSQLSELPWEFMCISLGLNWLLTFYWAVKLHRWKAILYPLMFTLSPFLSWIYMVYGICTAGQRTWGGPRADAGAADAKVTPQAAIEHAIATGDDLNVVPETFRPAMEVRKRRVRPSQLHPSSSVEGRFTSAEQEALRVDGKALRSPSSSDVDLEARTRQFGHESLDMSDSEGLSIHTPQRVITSSGDEEDSTKGARGKQRAVSYSSDEEYMTKRHNNTPIGNNLSNDEEHIARTGHTTPRAGSGSSDDEYYARRAASGPYGTFGIPDEDVYRPRDFRSSSESVITVIPRRPIVNGEPSRRRSRRRRRSTSSSGSGANSEELTRRLSLMLAQQSPSGSAVHAQPSSPLGRNSPMTALQKDEDIPPLQEPDGGAGSKKAIKTQAEPWSPRKSGRRRRPGSVHMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5Y1</accession>
    <name>A0A0D2B5Y1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234539.1">
        <property type="nucleotide sequence ID" value="XM_016381437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5Y1"/>
    <dbReference type="STRING" id="91928.A0A0D2B5Y1"/>
    <dbReference type="GeneID" id="27334188"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07105"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF576">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CSK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="71"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="384" mass="42640" checksum="115EB444208F3EDC" modified="2015-04-29" version="1">MSVDAARNEARNLEEEIRGKASSTTEYQGRLQRALDTLLLPIDSTPQETQESQPPTNVEILNHEGPTFGKYRYATFHADGQSSTIYKAESMDQSAPGQIVALKVTNIGSLNPPHNPERESRLLVKARHEHVVPLLDTQREAPGRFILVFPFLRQDLENLLRSGRLDRGQAKMIFDGLFQALEHVHGLGMVHRDVKPSNIMLASMQGPVYLIDFGIAWTAEDEDCEPADAKITDVGTTCYRPPELLFGYRSYDTSLDMWAAGCVVAEMIRDGGGAGAVGGLPLFDAGPVGSELGLIRSIFTTLGTPDSRTWPSARLYPDWGKMKFKEYPARDWREILPGATPRSIDFVRRTVCYEPTERLTASEALKQGLERADFGKSVKDSSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B714</accession>
    <name>A0A0D2B714_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234944.1">
        <property type="nucleotide sequence ID" value="XM_016381842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B714"/>
    <dbReference type="GeneID" id="27334595"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07512"/>
    <dbReference type="HOGENOM" id="CLU_102618_0_0_1"/>
    <dbReference type="OrthoDB" id="4112164at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27572" checksum="5F62E265277FE1A3" modified="2015-04-29" version="1">MSGPNSAAPITPAARLEAEQELQRHLESITNAMAVITKEKKIVDRMNGHHHFKYKITKIPSEIYLNEASDQPNDPLSKLDNDAMYRIFQSLPLDADRAALALTCKRHADTYELLKEKKWTVTVDGVKKREYYLPRPQRVTDIHRLQVLVRVNKGFMNPEGKWRLCYNCNQLIDTTHPDNQGTWGGDRADPSVENAGATKRARIRGPRCPLCVRADQLQLANHRAEFAQFKRLAKGITMKETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8B8</accession>
    <name>A0A0D2B8B8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235379.1">
        <property type="nucleotide sequence ID" value="XM_016379552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8B8"/>
    <dbReference type="STRING" id="91928.A0A0D2B8B8"/>
    <dbReference type="GeneID" id="27332291"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05208"/>
    <dbReference type="HOGENOM" id="CLU_030571_1_0_1"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="55"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="376" mass="41360" checksum="C66334A6019E51E7" modified="2015-04-29" version="1">MAPNLLHPAKKPEPLNAPPGASAKVQIVDGTARITAPTDVFMTPPIHGHTQMFAPAFSFLVEQVSSGRKILFDLGLRKDWQSHPPAVQSLISGPGWAFDVPKNVDEVLQENGVDVKGGAIEAVIWSHWHFDHTGDVSQFPTSTTLITGPGVKDSFFPLYPENENSPLLSSDFANRKHKELDFEGKSQLKIGGLRAIDYFEDGSFYLLDAPGHAIGHTCGLARVTSTKEGDTEDTFIYMGGDTAHHGGEFRPTEYLPLPAEISPSPYVSKFASVCPGHLFEAIHPRKKGVDPYYDLSTHVAHNHEESIHSNERMQVFDATDNVLVIIAHDMTILDPACGLEWFPHGTVKNWKAANAAEKVRWLFLRDFVPAVENSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8W4</accession>
    <name>A0A0D2B8W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235311.1">
        <property type="nucleotide sequence ID" value="XM_016382209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8W4"/>
    <dbReference type="STRING" id="91928.A0A0D2B8W4"/>
    <dbReference type="GeneID" id="27334965"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07882"/>
    <dbReference type="HOGENOM" id="CLU_386854_0_0_1"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF4">
        <property type="entry name" value="BLR0106 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="714" mass="79483" checksum="4758CCE9FE862CB8" modified="2015-04-29" version="1">MGKQTPVNKVIIVGAGPSGLLLGILLAKEGVKVQILEATNDLDKNPRAAHYAPSAVYELERAGVLEDVKAQGIHPDAVCWRKPDGSLIAGIKSRMDIEHPMVCLPLDKLDILLLEHYNKAPNTEVLWEHKVVSIDQDEHEARVHVETPTGKKTFSADYIVGCDGANSQIRRSLFGDLNYPGETLQKQIIATNVYYDFKKFGYWDSNFIIDENDWYMAARITDDGLWRVTYGDAWGLSTEEYLKRQPERFEKILPGNPKPGDYKLVSASPYKLHQRCADAFRVGRFLLAADAAHLCNPFGGLGLTGGIADVGSLFDALVALRHGKADDSILDKYSEVRREKWQKIIDPMSRANFSRVCLEEAESERNEFWALCKKIEEDEELAKQMAQAAASPKLRVPSANPPKPSTFDFGPLHTRLSCFGVLLHPDLYGLSEFLPPSPVLGHFSLRETSTRSVRATPKHHAKHWTTFGLFIQDASAWLWARVRRMADFSLVPSGHGNNYTGMLTRSIVFSAALFVFLAASGMTIASIIIPNWIAFDGSTPHGDPVHYTYGLHRRCSSTNIPPPLDSRSTRSIVMADSLQCVQFPRYNDCRGDDVYFCSMWRSVGFLMSFAVVLEGMTIAAFTILLVGGKQKREQGWGVLTILVALAAFVQAIGMALMAYLYENDEKFFSGWFLDKSWTMCTISWSFQALCAIAITLAAVILPSEGGYELIPDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9A4</accession>
    <name>A0A0D2B9A4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-repressible protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235699.1">
        <property type="nucleotide sequence ID" value="XM_016379872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9A4"/>
    <dbReference type="STRING" id="91928.A0A0D2B9A4"/>
    <dbReference type="GeneID" id="27332612"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05529"/>
    <dbReference type="HOGENOM" id="CLU_179513_0_0_1"/>
    <dbReference type="OrthoDB" id="10039103at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
        <property type="entry name" value="Grg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7456" checksum="446033B71F8149ED" modified="2015-04-29" version="1">MDTIKNAANYVSESISGATSTASKEANKNVAKDSDASLTTRAQAAGDALGDKIDEQTHNRKADVHKEAAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9H5</accession>
    <name>A0A0D2B9H5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235809.1">
        <property type="nucleotide sequence ID" value="XM_016379982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9H5"/>
    <dbReference type="STRING" id="91928.A0A0D2B9H5"/>
    <dbReference type="GeneID" id="27332724"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05641"/>
    <dbReference type="HOGENOM" id="CLU_007149_0_1_1"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000033">
        <property type="entry name" value="Anaphase-promoting complex subunit ApcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014786">
        <property type="entry name" value="ANAPC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01013">
        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="8">
        <location>
            <begin position="377"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW15593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="734" mass="81273" checksum="21B717883A4FAFCD" modified="2015-04-29" version="1">MSKTEVLPSNKATFASVFSQPRIRPPKHPQRFTATASKQLPVIKSMLKDQLRSLLGIGNEDFVYGNDDWIPGSGGPFRSHFGSCPEPQQIRQPTSEDHTTQLSRESGSPLWPQLERWKSTIGSSTLKKQLASVLIDLLAEFITWSYAGVYREGLERHLDFWVEHLLSRIAKWTCSHLEDDGRNAPDPAEVKKWKDMATARLGALRVDELFTIVVEWDATAPAIEDLRAFTTNPATRAYLTQDFANVLQARLLHPGASTVEILQIYISIIRAFRILDPKGVLLDRVARKLRRYLRERDDTVKVIVVGLLSDPGNSDGQETPSDPTVLTELAVELNNTNAQSSGADDADFDWNNMDWVPDPIDAAPDYAKTKNDVIGSLITLFDTKEVFVRQLQSSIAERLLKKNKDFEQEISVLEHLKLRFGDAALQGCEVMLRDVLDSRKVDTVVRRDRGMHDPDSDSPVVHGRRTKEEGEGDGVHLHAKILSRLFWPAMPEQGFTVPRVVQQQQESYEAGFEALKQNRKLTWINSMGQVEVELEFEDRTVVEEVLPWHATVIYAFQDASADDGLSPSSSSGPVSKTVAELAAELNMSATHVRMACVSWVSKRVLAETSRDTFVVLDRLPDESDNAMQDDGGGGGGSSGRVHDSAAAAAAAVAQAAKEAEEEERKAKMAVYHQFVVSMLTNQGAMPLSRIAMMLGIVVPGGFPFSNEELKEFLAGMVKDGVLDIGHGGAYKIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9Z3</accession>
    <name>A0A0D2B9Z3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_05873</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236039.1">
        <property type="nucleotide sequence ID" value="XM_016380212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9Z3"/>
    <dbReference type="STRING" id="91928.A0A0D2B9Z3"/>
    <dbReference type="GeneID" id="27332956"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05873"/>
    <dbReference type="HOGENOM" id="CLU_067096_1_1_1"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="30"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW15823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="234" mass="25678" checksum="6C7EC40B68D0ECEA" modified="2015-04-29" version="1">MANSTSTTTTTTTTTTLPQTGTSLRHVLLPQTQLLSTWMTSLRDQKTDNKRFVEVAQKVAAQLMVHALEFVPTTDREVWTPTSHPYPGCTYTQKLCGVSIWRAGASLEDALRQAYDGPLSFGKILIQRDEKTARPTYLYSKFPSSIQESYVFILEPMLATGGSICKAVQLVLDQGTPEDRIVVVSIMASRTALNNMGASFPSVAVVTASIDQNLSPERYIVPGLGDFGDRFYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAY8</accession>
    <name>A0A0D2BAY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236369.1">
        <property type="nucleotide sequence ID" value="XM_016380542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAY8"/>
    <dbReference type="STRING" id="91928.A0A0D2BAY8"/>
    <dbReference type="GeneID" id="27333287"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06204"/>
    <dbReference type="HOGENOM" id="CLU_490024_0_0_1"/>
    <dbReference type="OrthoDB" id="5421784at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="139"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="64922" checksum="DAFB57DD046B8C24" modified="2015-04-29" version="1">MERPAKRMRISNPEVRNPRDTGSRMTEGLFTSELGIRSDDSDEPVHATRTISLSDFQRRNIYGEYQRVPRQVLPRGDQGIYLRPRAPDATVTASVVEINVNDGTSVSKVTEITAAPSGTVVSLSNMGTAAVSLTVPGNEATDSSNTASETSTSTTDDPSSTSSSTTSGTVEVTTTSTGSSTTASTTGSIIPNGPTNGTTTSATITELTVTVTATSTYEISLINGTFITPNVTAFVTATDYSQTGLITDIDTATTSATFTFGDLTSTPSPTYSSDYFDSGAASTGYLPGGIVQTGSPTETSGSASSSSPSSKSDSGGDGPGLSPTQQQVVGGVVGGIAGIAVALAILLVVLRWYRRRLKARGQLPEQIAARQLGSDSDNRYPMSMRSSNTPFTAAVAHNLRRLRPHSLQTNATTATGGTDFSAKDSERGFQRIAGRKIAPVLSSGGDPYGGNYGAFEKEAEAGPSDPLHGAERSLAGASFYRDHDGFYGGKGNHSPTFPPSPTTAASGGKAGELPFGLAGLGSTVRDFAGTIGSDSQTSLNAPSRPEGIAVMRPSPARTPVTLSPAASSIRLPIQPPPTLDEDAPPLPTGLNIPGQMQRDGVGRSLASQDGSHISRSSGRSGTRFVENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCF5</accession>
    <name>A0A0D2BCF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_06361</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236526.1">
        <property type="nucleotide sequence ID" value="XM_016380699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCF5"/>
    <dbReference type="STRING" id="91928.A0A0D2BCF5"/>
    <dbReference type="GeneID" id="27333444"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06361"/>
    <dbReference type="HOGENOM" id="CLU_017266_1_1_1"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="13">
        <location>
            <begin position="70"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW16310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="496" mass="55433" checksum="0163D353E107ADDD" modified="2015-04-29" version="1">MSIRRTLWQSLHCTNNVLSPLKPIGRLPRAPLRSYNSASGIVSAADLSFGQPVHETHPHVLQPGELTPGITAQEYADRRTRLAAKLPDNAIAIVAASDVEFRSGSVFYEFHQDPDFFYLTGFNEPEALAVIGKDSTGTDHTFHLYVREKDPKAEIWDGARSGTQAARDVFNADETADISRVKTILPELVGSASGIYTDITTPDSTQSALRRFLYGKPRRTTEFADLLQSNKINRLRPVMNDLRAFKSPAEIEVMRRAGRASGRAHTEAMRKAWTREKQLDAYLRYQFVTQGCDTSAFEPVVAGGKNALGIHYVRNDDVLQDDEMVLVDGGGKYGGYIADITRTWPVNGKFSDAQRDLYQAVLNVQRTLISLCRGSSTMSLDKLHSVAEEYLSSELRQIGFDMSSKAVEKLFPHHLSHYVGLDVHDTVGYSRKAVLQEGHCITIEPGIYVPDDERWPKHFRNMGVRIEDSVCVQEDTPYVLTTEAVKEVVDIEALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCY6</accession>
    <name>A0A0D2BCY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236686.1">
        <property type="nucleotide sequence ID" value="XM_016380859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCY6"/>
    <dbReference type="STRING" id="91928.A0A0D2BCY6"/>
    <dbReference type="GeneID" id="27333607"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06524"/>
    <dbReference type="HOGENOM" id="CLU_044876_3_2_1"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="305" mass="32089" checksum="519F018345D43B51" modified="2015-04-29" version="1">MSTKVAVAGGTGNLGPQVVNALLAANYSVTVLTRTGSSSTSKLPKSPQLKVAEVDYSSVASLSEVLQGQDVVVSTLGSAVIGGQKPLIDAAVAAGVKRFIPSEFGSDTTHPKSSQLPVYKGKVETQQYLKAKAAENPGFTYTLVINGAFLSWGIQVGFLVNIQSHSATVWNGGDVPFAATNLETIGKAVVGVIQHLPETANRAVYVQEALITQNQLIKYVKEIDGVEWQITPKETAKAYEEASAELAKGPDGNIGAAMLGYLMSAIFDASYGPDFSSHLDNELLGIKPYTEDDVKQLVKGLVGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BD44</accession>
    <name>A0A0D2BD44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_06555</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236716.1">
        <property type="nucleotide sequence ID" value="XM_016380889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BD44"/>
    <dbReference type="STRING" id="91928.A0A0D2BD44"/>
    <dbReference type="GeneID" id="27333638"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06555"/>
    <dbReference type="HOGENOM" id="CLU_003824_0_0_1"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="725"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW16500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="839" mass="92439" checksum="59F1AB6ADCAD5C8B" modified="2015-04-29" version="1">MTSRTSCRCTQVQSLIDYPVKQFIRNVRASKTIADERAVVQKESAAIRASFREESHDSNIRRNNVAKLLYLFTLGERTHFGQIECLKLLASPRFADKRLGYLGTMLLLDENQEVLTLVTNSLKNDLNHSNQYVVGLALCTLGNIASIEMSRDLFPEIETLISTANPYIRRKAALCAMRICRKVPDLQEHFLEKAKLLLQDRNHGVLLCGITLIASMCEADEAEGGEEGLVEMFRPVVPHLVRTLKSLTSSGYTPEHDVSGITDPFLQVKILQLLRVLGRGDATTSELMNDILAQVATNTESTKNVGNAILYEAVLTILDIEADSGLRVLGVNILGKFLANKDNNIRYVALNTLIKVVAIEPNAVQRHRNTILECLRDPDISIRRRALDLSFTLIREDNVRVLVRELLAFLEVADNEFKSVITTQIGIAADRFAPNKRWHIDTMLRVVKLAGNYVREQILSSFIRLIATSPDQQSYSVQKLYSALKADITQEALTLAGVWVIGEFGDALLQGGSYEEEELVKEVRESDIVDLYSTILNSTYANQVVTEFIITSSMKLTTRMSDQSQVERIRRLMQSRTSDLSVEIQQRAVEYSNLFGYDSIRRGVLERMPPPEIKEEQRVLGQATAPAKDKRKTLKAKTNTKVSKTTESDMLLDLMGGSDVPAVTASATLNGRQQTADLLADILGGGASVSSPPPQTKSPVPTSNTDSIMDLFGNGTAKNASPALSGLQAHPAYNKNDLVVFMQLSKSSSGAQIVARFKNNSSFGSMTGVGLQAAVPKSQKLTLQAINRSTLGGGEEAAQAMKVVPATGSLPPKLRLRLKISYTKEGAAPVTEQVDWTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDE7</accession>
    <name>A0A0D2BDE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_03823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236851.1">
        <property type="nucleotide sequence ID" value="XM_016378174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDE7"/>
    <dbReference type="STRING" id="91928.A0A0D2BDE7"/>
    <dbReference type="GeneID" id="27330906"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03823"/>
    <dbReference type="HOGENOM" id="CLU_041583_1_0_1"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW16635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="397" mass="43749" checksum="3BE17917F3C1D3D8" modified="2015-04-29" version="1">MGPKKAFSSSSSSATSKPKLASKRSNRKSLKSGRPPLLSSSPSSSTKVNNGGGPSITAPSLSSRHTRKLIRTHHTLQKRLSRARAENDTALVEELESQLSASGGLATYQHASTVGQSAERGGDSSRVLVRWLKDELDFCRQAATVTTVAAAEQRRQQHQPRQMMKRLRILEVGALSTTNALNVPHATTVRRIDLRSSGPGIEEADFMQFPLPDGASGKGVWQGERGYDVLSLSLVLNYVPDARGRGDMLRRTTRFFFTRSDSDSDSDRAGGDTDMDVDESARDRDGGHGRDIIQSQTSSSSSSSSRRPPKLPCLFLVLPAPTIHNSRYLTPSHLDLIMSSLGYTRLETKTTRKLHYSLWRYDRDRRDRWIQDGGPTVFAKKEINPGPGRNNFCIVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BE53</accession>
    <name>A0A0D2BE53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_12084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847506">
        <property type="protein sequence ID" value="KIW09669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229885.1">
        <property type="nucleotide sequence ID" value="XM_016386391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BE53"/>
    <dbReference type="GeneID" id="27339167"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12084"/>
    <dbReference type="HOGENOM" id="CLU_2109044_0_0_1"/>
    <dbReference type="OrthoDB" id="4124760at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="115" mass="12996" checksum="77CA9DA2CCA9956E" modified="2015-04-29" version="1">MSLVMNLAAFGLQRFSPREILWLALLISNILLALGGLFKTELFKTLYFKIRLLYLGHVGHELPMRRSSSREQIVSNEHSGANSTTTFATMNGRVNELDQALDQSMQTLEGIERKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEK6</accession>
    <name>A0A0D2BEK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230040.1">
        <property type="nucleotide sequence ID" value="XM_016386232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEK6"/>
    <dbReference type="STRING" id="91928.A0A0D2BEK6"/>
    <dbReference type="GeneID" id="27339008"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11925"/>
    <dbReference type="HOGENOM" id="CLU_046066_1_0_1"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF13">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="270" mass="28788" checksum="20A667A2E35A73FE" modified="2015-04-29" version="1">MASTPSTAILFVPGSFALPEFYDPVFEKVRAKGYNIQGLHMPTVGLSASEGRPTGPGGGPPTMYDDAAYIATEAERLADQGTRVVIIGHSYGGVPVSQSTKGLSVADRSARGLPGGVARLAYMTCLVPGVGETAVDVLSKGPQDQQVEMDVDDSGWMTHRNPEKTASLILQTIPLDEATALVKLFPKHSAPSFVNQLTYAGYKDIPVSYLLCEDDLCIPPDVQQRGIDIIEEQSGSKVDVTRIKADHCPNHSAMQSVVDWIVSVAEKAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF70</accession>
    <name>A0A0D2BF70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">INSIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_04823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237844.1">
        <property type="nucleotide sequence ID" value="XM_016379167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BF70"/>
    <dbReference type="STRING" id="91928.A0A0D2BF70"/>
    <dbReference type="GeneID" id="27331906"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04823"/>
    <dbReference type="HOGENOM" id="CLU_039316_0_0_1"/>
    <dbReference type="OrthoDB" id="205546at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF3">
        <property type="entry name" value="PROTEIN NSG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="36971" checksum="8EA92E732CCAD4FF" modified="2015-04-29" version="1">MEMPQVYRPIPRRTFEIPSTSTDSSMPPSPASEGVNGELPSGSKSDSTPGRTRSILNLTSSTLLGIYSPISDGNREDLSTPWGTGAQTPSKRQSIDDSLHRKPEVTWQQDGSGPRLKPKPKRRGFPALVLQTALLFTFGLGYGSIVTHLHKTRRITPVPVPDVEQHSVWYLISWGIFGILLGNALPLLDAVWEGSGAHGTTKNQGTSNTKSATVGSDETDASDGGLGPMWYSAVRSIGVFVGIAFAVRRLPWQSTLQVALTLALANPFLWYLLDRSLPGFAFSAIVSVAGTLVLLLVDPNFVPVPAIHQQVVSDQFGVYTWLASILFCTSICFGAIGRRLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFX1</accession>
    <name>A0A0D2BFX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230485.1">
        <property type="nucleotide sequence ID" value="XM_016385541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFX1"/>
    <dbReference type="STRING" id="91928.A0A0D2BFX1"/>
    <dbReference type="GeneID" id="27338314"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11231"/>
    <dbReference type="HOGENOM" id="CLU_103834_0_0_1"/>
    <dbReference type="OrthoDB" id="4094614at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038843">
        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523:SF1">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239084" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="23831" checksum="8C7C321073BAF43B" modified="2015-04-29" version="1">MKFTTTVAAVAALAVSAHAATTTSETGAWDDWTSSTTSTTTKKTTTTTVATTSATGVWDDWTTTTTTTTTSSDPAWADWTTTASTTSAKTTTTTTSGAVVWGDWTTTSAPASWTTKVVSTITTYVPGPTNIVHAGKTYSCTGATTLTITDCPCTISVPVWTKTATSCSTPVAAVTTWGTWGTPVAPASTSTPVAPVWTYTPSSSLPVAPATYTGAANALNVGAGLAGVGAIAAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BG09</accession>
    <name>A0A0D2BG09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230525.1">
        <property type="nucleotide sequence ID" value="XM_016385581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BG09"/>
    <dbReference type="STRING" id="91928.A0A0D2BG09"/>
    <dbReference type="GeneID" id="27338354"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11271"/>
    <dbReference type="HOGENOM" id="CLU_028286_3_1_1"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="134"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="330" mass="36989" checksum="5614642C7525A70E" modified="2015-04-29" version="1">MCTIQRLFIYPVKSLPPVQVSSVELTNEGLRFDRCFVLVTPPKDNSKEAKFLTIKKHFKLMLFKPTIDDSWTKLTISHIHASPPSSITVPLTPSPLSLLQNKTFEVSIFGTTAIGIDLGEESASFFSNHLGQDVRLLSIGGTGRREIPGAAYLPSQHNALSLALREGLQPQRIRFADAAPLLITSTASEEDARSRLPKDWQHEDIIVRFRPNIHVDVKGQLPAYDEDNWSSLLVRSQSDEAQEVTIKCIFRTVRCLSLNADPDTGEMIHRDRQLYGLLASDRRVNDKFPHKPVFGQYGFAGPSGAILRTGDQVFVTERKQRTQDPEADKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHE5</accession>
    <name>A0A0D2BHE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02292</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238221.1">
        <property type="nucleotide sequence ID" value="XM_016376651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHE5"/>
    <dbReference type="GeneID" id="27329375"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02292"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="58"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="547" mass="60011" checksum="F8621A42AA0F2124" modified="2015-04-29" version="1">MAEHQATSDTEKVQCEMLEQRLPPDVIQPEPQWARYIPGGYSKSRCLRIRGAPMMCAVLLLAGTAIMFFGYDASVMSQVNSNKDYLHLMRLEGGTSGDSAFIGGIVSIWFLGFAIGGLLVGIYADKVGRLKTIQLGCVWALVGAALQAAAQNVSMMMVGRVIGGVGCGHLNTIVPIWSSEIADPKYRGAFVAAEFTMALLGSTLAFWMEYALVKTHAAPFAWRFPVAFQVVFLIVIMIITPFYPESPRHLARSGRVDEAQEILEQCRSNPDHQAILQEIEEIKETIRLEAKAASTTYYSMLFRKDDLHNRRRILLGAGIQVLQKLTGIDFIATYAPQMFALSGFTGNKPALLAGGNFFNYTASLALAVFLADRVGRRKLMLSGCTMMGTVLVVGGVLSKMTLTHQGTDKAAGFGTGVCAILYIYTFIYGSTWLTTCWVYPTECFPLATRAKGTALAVVAFSVAGGVVNTIIPYLITAVGFWVFVAFAVINVLMLIPIYLFYVETANRHLEDLDILFATESPLVWRAEKEFARRKAESSRLDQPTGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BI60</accession>
    <name>A0A0D2BI60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238864.1">
        <property type="nucleotide sequence ID" value="XM_016377294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BI60"/>
    <dbReference type="STRING" id="91928.A0A0D2BI60"/>
    <dbReference type="GeneID" id="27330020"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02937"/>
    <dbReference type="HOGENOM" id="CLU_072829_2_1_1"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="164" mass="18388" checksum="F5AEAF9D80BF790D" modified="2015-04-29" version="1">MSAAAQPITDEQFAVAIQDLPFENLYSKAAEIENSISHLVRSNEHLQKYIDSINSDESLPDATRQEGDKECSEAIQENVVVIDRQRDRIRLLKQEVERRGGRWHELNKEPNTNGSSGTTSTNGGQLTANSSAGAPRRLTDDELSQRMLERLAEDERDEDDGVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIH6</accession>
    <name>A0A0D2BIH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosolic Fe-S cluster assembly factor NAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cytosolic Fe-S cluster assembly factor nar1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nuclear architecture-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_02683</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238611.1">
        <property type="nucleotide sequence ID" value="XM_016377041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIH6"/>
    <dbReference type="STRING" id="91928.A0A0D2BIH6"/>
    <dbReference type="GeneID" id="27329766"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02683"/>
    <dbReference type="HOGENOM" id="CLU_018240_0_1_1"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000042">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1780:FF:000004">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor nar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="10">
        <location>
            <begin position="118"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW18395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="593" mass="63818" checksum="14DEAD7AF04CE3BE" modified="2015-04-29" version="1">MSAILSADDLNDFISPGVACIKPVETLPAQAESNPYEVTTEDKVQAPNPAPASISLTDCLACSGCVTSAEAVLVSLQSHTEVLNTLDSYPPLDVRYLVESRNGSVNGHAPPPPDAKLFVASVSPQVRASLAATYGISEHQSGFLIEQFLSGSQGLRIGGHHNSGFSYVVDTNQLRQACLVLGAEEVADAIEAKSKPKPVLTSACPGWICYAEKTHPYILPHLSNLKSPQALSGTLLKSVLSKTLGIPPSQIWHLAIMPCFDKKLEASREELTHKWWQSSSLADAPVRDVDCVITSRELLSLAEARGVQLAQLPLQPLSPSERTPFPEGRLSSFLFPKPRRRSEQSVTAGSSGGYLYHIIMTEQARHPGSTISVQRGRNADVMEYALVSSSGQTLMKCARYYGFRNIQNLVRKLKPARQSKLPGAARRMAAGASGGSDYAYVEVMACPGGCTNGGGQIRIDDVASILPQTRGEEVVNTSPQSQKEWLRRVDEAYYSADSECESESDGDIHMTNGSVVENGHLTNGSQQAINGINTGEVQDFLNQWSSLVGISLRKLAYTTFREVESDVGKNKASKTLDDTARIAQIAGMSGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ84</accession>
    <name>A0A0D2BJ84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pex N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_10704</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231620.1">
        <property type="nucleotide sequence ID" value="XM_016385018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ84"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ84"/>
    <dbReference type="GeneID" id="27337787"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10704"/>
    <dbReference type="HOGENOM" id="CLU_024591_2_0_1"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF4">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="16">
        <location>
            <begin position="78"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="405"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW11404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="458" mass="51348" checksum="B5C7ADE0C06CB1C4" modified="2015-04-29" version="1">MSSSSFAAAQERILARQHVRQQESQATNSRAIPPPVRSLTRLTHSLRPELSAFWSTLLDSEGTRPAFRVGQVDAELLDEELLGLLKTQVGDALKYLGPHLQDDWSQEILLGLRAVLFKLSIWDNDASYGAALQNLRYADARNSSLALPKPTRWQKALYGMVTVFGRYGWDKWEDWLIDQERGYTAPSETVQRLMRLTSFASTAHSIAAFCSFLVFLVNGRYRTLTDRLLRLRLVSPSNQVSREVSFEYLNRQLVWHAFTEFLLFLLPLVGISRWRRWLARAWKKTKDAMRSESTDEDEGKIKSGPLSFLPERTCAVCYEEQNPTSTSEAEILGANTGAGGGVVGSATTDVVNPYETIPCGCIYCFVCIAKKIEAEEGGGWTCLRCGEIIYKCQPWNGDIVVPKKTSQKNGKSVGFSVSEQVHSDELEEEESLDEAPEMMESNLISSQWSMPEESSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ96</accession>
    <name>A0A0D2BJ96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_10714</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231630.1">
        <property type="nucleotide sequence ID" value="XM_016385028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ96"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ96"/>
    <dbReference type="GeneID" id="27337797"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10714"/>
    <dbReference type="HOGENOM" id="CLU_013819_3_0_1"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="13">
        <location>
            <begin position="497"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="250"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW11414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="629" mass="70699" checksum="2535D7F472682EA6" modified="2015-04-29" version="1">MASRKTQQEIDKTFKKVDEGIQAFEGIYEKIYSSTNAAQKDKLEDNLKKEIKKLQRSRDQIKTWAAGNEIKDKSALLEQRKRIEKCMEIFKAVEKEMKTKAFSKEGLSQNTKLDPKEKEREELCDFLSDQLEEINRILTEELEPEAGNLQAALKKKQKDNSKADRLAEIESMTETYKWHESRLQLLLRSLQNGNVENDVVAAIKSDVEEVVREGREPDFDAEAYEGIYDDCNLDSEEAQFGLANEVDRISSQDTQSIQEDNDPEAVVPKKTKADHAPARRPSTQLKSPLPALATLNTMPPPPPVPKDNTMKPAPLPNRPAGETLKYASAAAAAAASDKSGVGIAPLPPPIAAGPAPASHPLPAPLRTSTTTSPASVPAQPVEKTASPAPIAASMDGSISHDQSSHSKSPTLSSTSAPAASVPSSIPPTPAMDKSEAVQEPVIADELPTTNGESHEDTVESIYHLPPGLQDLLDSFETTKSRATQPPSQLARLLQASQETCPEPSDSDRPQHYRPTFKYNTPAHYPQDVLPIFDDPALYDNQRLETDTLFYIFYYRQNTYQQWLAARALKQQSWRFHKQYQTWFQRHEEPKQITEEYEQGTYRFFDYESTWMNRRKADFKFVYKFLEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJA5</accession>
    <name>A0A0D2BJA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239194.1">
        <property type="nucleotide sequence ID" value="XM_016377624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJA5"/>
    <dbReference type="STRING" id="91928.A0A0D2BJA5"/>
    <dbReference type="GeneID" id="27330350"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03267"/>
    <dbReference type="HOGENOM" id="CLU_483140_0_0_1"/>
    <dbReference type="OrthoDB" id="4203839at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="470" mass="52316" checksum="8832D1F073DFE48A" modified="2015-04-29" version="1">MSHYFGNTAMLSGSSPVLDQAQSQLNSARMSHAEIQQELQSLMQYRAMTPMSVVEGQQRDGEMLQLRVRLRQMEDEMNGLRDTIARQQATIRNQSVAISNPRQYYPAPKDNTPQDRMQGHMANRQGPPTVRSTTHQTMYHPHGPSSANLFGSPAARPSNNTGKTPQGVQRTPFNPPSARGGGQGTPGSATQHPDNHMALVPVSAVTSTATTVKGQIARVFDMVEMFSWAHVNFPSSHGDNQLNKSLKERFLQAAAPTQAFPLMTSPATRYLLVAKVINAWILDKVLRADSFRGFNANIDSMIDAAKNQVYQSTPAQVKFQLFNKIAAQMRELRQNVQFKRFVDKLTQDRGNELWELMAPLMHTKTSRDWDDMATLMEEAHRLAIMMFSGTDQYRFEVKEGGSFFKKAAMAVVSRQTLPDGTTTPDQLEARGARVKLGVSPQVVVKNSTPMGLINERTVVPAKVLVDLTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK19</accession>
    <name>A0A0D2BK19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_03562</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239484.1">
        <property type="nucleotide sequence ID" value="XM_016377914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK19"/>
    <dbReference type="STRING" id="91928.A0A0D2BK19"/>
    <dbReference type="GeneID" id="27330645"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03562"/>
    <dbReference type="HOGENOM" id="CLU_014210_0_0_1"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000039">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="106"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="489"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="651"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="692"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW19268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="721" mass="80042" checksum="9039E9DC039921F3" modified="2015-04-29" version="1">MASSDYNYDDQGQFFPFFMLTMAGIVTLPLTYNVFKASTDLEQTAAHVKSDFKPKDGDLIDEQRRKRKRRNRKTKRIIAMVSGYAFMAYMTYLIVITQRTVPQIWDPYDILGVKRSASEKEIDRFYKRLAIKYHPDKAKPDPAKNETIETINDRWVEMTKAYKALTDEEIRNNYLQYGNPDGRQSTSIGIALPKWMVEEGNRYFVVAFYGILLGIILPYTLAKWWYGTQALTKDKVLHASSGNLFREWKEDISEGGVVAATSAGEEFKETLKGARSDAGAAKVESKVLKSSMLSDADKARLKSIEDPVRRKTLALLWAYLARIDLEDAELEREKYAVAPTAFLLNNSFASVTLPFQVVKPLLSAYHTSQSIIQAVPPNASPLLQLPNFTPELADKITGTSKEPVTLQKFMSFPPSTRRSLCSSLSETQYNQAMQVASQIPHVQVEKAFFKVVGERVVTPGSLVQLVVKARVIPPGAKDVPPIDPLDLEDIDPEEGDLDALHGRKPAKSKRRKTIDGKVIEDESTPGSVQPPLAHAPYFAADHAPRWHIFLAEARSGRISVPPFTFTAFDKPIFNEDGTPTFNMLTLKCPFQAPPQVHAFPFVLHLVCDSYIGLDSKLDVILDVRNPSEANQVDSDDEISEPDEDTIAGQLQAMKSGGLSGATTGSTTTKRKKKTTASQVDVPVVGSGNAGAESDDDDESDTEGDESDDTSETDTETEDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLL4</accession>
    <name>A0A0D2BLL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239671.1">
        <property type="nucleotide sequence ID" value="XM_016374395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLL4"/>
    <dbReference type="STRING" id="91928.A0A0D2BLL4"/>
    <dbReference type="GeneID" id="27327110"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00027"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="316" mass="34584" checksum="6CDE98A361504361" modified="2015-04-29" version="1">MTRSQGFQISEIPDLNGYVVIVTGGNSGIGYETTLQLAQHGARVYIAGRSPARVDEAITKMKQTNPGLDVRFLKLDLQDLQSVKAATSEFMQRESRLDILINNAGIMACPYGLTKDGYELQWQTCFLAPHAFTLSLLPLLKSTALQYPNNKGRVRVVNVASDAAFLMGPRHIIYDDPNMSGVTGSLSPWKRYGHCKLAFILATRALNDRLSGSGVTAYSLHPGLIRSNLQSSYPGMIGALARFSMKITPTISPQDGSRTSLYCATSSHAPSHAGRYFVPYGKLDVDRSKWVDDAKEVTKVWDLADSQLKASGIYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLN3</accession>
    <name>A0A0D2BLN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239686.1">
        <property type="nucleotide sequence ID" value="XM_016374410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLN3"/>
    <dbReference type="STRING" id="91928.A0A0D2BLN3"/>
    <dbReference type="GeneID" id="27327125"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00042"/>
    <dbReference type="HOGENOM" id="CLU_026108_1_1_1"/>
    <dbReference type="OrthoDB" id="5554151at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053088">
        <property type="entry name" value="Beta-glucosidase/SUN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239103" description="SUN domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="52352" checksum="6CFCAE3016E7E2E1" modified="2015-04-29" version="1">MRKRTVTSSATALLLLTASVVSAKHGVHEHLESLHKRHRAHRHLDMRSTAENGAQGIELRSVEETTSKAPVEKRGGQCAFPTDAGLVAVTPGEQNAGWAMSPDQPCLPGNYCPYACPPGQVSVQWDPSATSYSYPKSMNGGLYCDNNGNIQKPFPDKPYCQSTATNIGVQNNAGGVVSFCQTVLPGNEAMLIPTSVSDYATLAVPDTSYWCGTAAHYYINPPGIDTETACVWGTHANPYGNWSPYVAGANVDKSGNTFIKLGWNPIYLEPTTPFRNDMPNWGVKVDCPNGGCHGLPCSIDPSQNQVNQMVGSASDGAGGGAFCVVTVDQGATANFVVFSSGGDQSDNNSNGNSNSGSSSGSGSSATGWNKGGQFYQTTTSPVASTSPSTTSSTTTSESTTSTAWAWSSSTTTSSTQVQTWTSASSSTWHSRAPTHSPYYSIFNSTTISTGRVDYSSVEATATPSGPTASAQPSIVSATGAASSVQVSVVGLLSALAFYAVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMB6</accession>
    <name>A0A0D2BMB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">xyloglucan-specific endo-beta-1,4-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.151</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Xyloglucanase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Xyloglucanendohydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>xyloglucan + H2O = xyloglucan oligosaccharides.</text>
            <dbReference type="EC" id="3.2.1.151"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.151" evidence="3"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239956.1">
        <property type="nucleotide sequence ID" value="XM_016374680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMB6"/>
    <dbReference type="STRING" id="91928.A0A0D2BMB6"/>
    <dbReference type="GeneID" id="27327397"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00314"/>
    <dbReference type="HOGENOM" id="CLU_073364_0_0_1"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033946">
        <property type="term" value="F:xyloglucan-specific endo-beta-1,4-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="307" mass="33071" checksum="19FA037DA88FC355" modified="2015-04-29" version="1">MGIKSLISYGFLILPVAVTLGVLLGLRSYRVSHGFAPPFVSNKISHKQYCQLSFGISPSTTGQQYTLNPNQWGVIEDTTVGGLCLNVTSFDNGSYPTRTTAPEWSITWQFDQGPPTQPVHAFPNILVDPDNNVLPVEISAVSAINITTEWHYGVGTSLPTDTNTAELTNAELNANVAIDMFIDSNQHAATSTRDAKYEVMIWLADFGASTQPIGLEQGSRKTVDIGGTTFNLYFGVNGQQQTVLTWVAAGTVQSISADFKPLLEDLTAVGGPSTTDYLGYLAFGSEALWSTTNVTFSNPVLSMDIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNE9</accession>
    <name>A0A0D2BNE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mannan polymerase II complex MNN10 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_01028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240669.1">
        <property type="nucleotide sequence ID" value="XM_016375393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNE9"/>
    <dbReference type="STRING" id="91928.A0A0D2BNE9"/>
    <dbReference type="GeneID" id="27328111"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01028"/>
    <dbReference type="HOGENOM" id="CLU_021434_0_0_1"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000117">
        <property type="entry name" value="Glycosyltransferase family 34 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW20453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="57113" checksum="A3A9726CC2C11CA3" modified="2015-04-29" version="1">MSSTRTPSPLRTGRWSAHGSADQASTLNGLGLGLDLSAQTNGYSGNDDQWAAAKAKSAQVRGFPTIQTKNEGFFQRSRRKLTSTLPVFNSPYPPLSANWKDPEKLGRSRWSPGRESVFSMVKTLLGNLLRKCKFLVIILALVTISTLIMSQTNLLSSIRSNAHLGGGSKFVIVLGANEGGGVMSWKGPREWAIERDSVKNKKRYAERWGYQLEITDMSTKKRYAHEWRESWEKVDLLRNAMARYPKAEWFWWLDLNTFIMEPSRSLQSHIFRNLQDNVYRDINVYNPLNITHPPVTKFLDPISRSPTGDNLSSSIDIIIPQDCSGFNLGSFFIRRSPFTDRLLDMWWDPVLYEQKHMEWDHKEQDALEHLYASQPYLRTHFAFIQQRKINSFPPGACAVETKEEPSDADKDKAQKSTTDPRFHYSETERDFMVNMAGCEWGRDCWAEMYSYRELSNKLNRSAWEKFKDSASGIWTSVKGMIGQKKVDQDNKGEDEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNX4</accession>
    <name>A0A0D2BNX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_01178</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240819.1">
        <property type="nucleotide sequence ID" value="XM_016375543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNX4"/>
    <dbReference type="STRING" id="91928.A0A0D2BNX4"/>
    <dbReference type="GeneID" id="27328261"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01178"/>
    <dbReference type="HOGENOM" id="CLU_030988_1_1_1"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23811">
        <property type="entry name" value="UBCc_ScCDC34-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000063">
        <property type="entry name" value="CDC34p Ubiquitin-conjugating enzyme (E2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW20603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="254" mass="28977" checksum="79406836CD55717A" modified="2015-04-29" version="1">MSSQAVLLKEYKALQKEKWVQIDIDEDNMLHWNIALMVVNPDSLYYGGYFKAQMNFPKEYPYKPPDFRFSKPLWHPNIYADGRLCISILHAPGDDIMSGETAGERWSPAQRVESVLISILSLLDDAEISSPANVDASVMFRDDKEAFKAKVAQDVEASKKDIPEGFVMPTHESTKPVIEKVDDDFWQDSDAEDVDFDDFGDFDDDAANGSESDQELNNDSEDEETYDEDEDDTEYAKGKRREDRLDSDMTEPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP20</accession>
    <name>A0A0D2BP20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_00850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240491.1">
        <property type="nucleotide sequence ID" value="XM_016375215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP20"/>
    <dbReference type="STRING" id="91928.A0A0D2BP20"/>
    <dbReference type="GeneID" id="27327933"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00850"/>
    <dbReference type="HOGENOM" id="CLU_135754_0_0_1"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW20275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="124" mass="13935" checksum="EFE8D247510DDBD6" modified="2015-04-29" version="1">MAAPPSAYKDRQFLAVIGDEDSVTGLLLAGVGHITDPPDSQKNFLVCDGKTEKSTIEQAFNRFTKERKDIGIVLINQHLAEVIRDTVDKFQDPFPAVLEIPSKDHPYDPEKDSVLRRVRRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP59</accession>
    <name>A0A0D2BP59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240526.1">
        <property type="nucleotide sequence ID" value="XM_016375250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP59"/>
    <dbReference type="STRING" id="91928.A0A0D2BP59"/>
    <dbReference type="GeneID" id="27327968"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00885"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="37585" checksum="631CF1D729BFE50E" modified="2015-04-29" version="1">MTSNSTFNQETGASEVAKVYSDAVRDKTVVIVGVSPQSLGESTAMALASQSPGLLVLASRTTLKMSAVASKIKAQHPDVRLETVEVDLASLASVREAADRISEVVDDKIDILINNAAVVMQTHAYTKEGLEMQFGTNHIGLFLLTNLLMPKLIRAAEKSPSKGTTRIVNLTSAGHIISPVRFSDYNFTKRPEDIPEQERPMSRPGVSFDPPPGKTYVPFVAYGQSKTANILMSVSLSEKLAQEGVRSIATHPGSIWTDLSRDLDEEHQNLVSKTGSFWKTLDQGSATTLVAALDPKLSEDTSVIYLSDCQVAEPAAHAKDPIAAERLWKLSEEIVGQVFAYGDKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP89</accession>
    <name>A0A0D2BP89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233125.1">
        <property type="nucleotide sequence ID" value="XM_016382422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP89"/>
    <dbReference type="GeneID" id="27335179"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08096"/>
    <dbReference type="HOGENOM" id="CLU_090700_0_0_1"/>
    <dbReference type="OrthoDB" id="3354680at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="309" mass="33800" checksum="5AD5282AEED1744B" modified="2015-04-29" version="1">MITSSRILAATVAVTAPYYLYNVSHSLSSVPTSNTRTESPPPSFVQSQTHLSVVNPRDHKGVTDSRSITFKLPPSRQSWSDEQILATFVQGYFGGWVFTPERRLLGLLNILLRRRIVGFSSKLRLDPASSSSSSSSSTTTTTIFPRWIIFCYQRELKLTLFAAIKDDPGRDQIWSCNDLSPSKLPPLYATLFGAFQVVDYHISTHDDDTGTGDSAGESYVDIGFGSDTTHFSGFHRFSVHRGPYDKGDHATTESGAKSSSSGTVTITNSSVACNPSANTQSRLGSLHAFHKVYAMLLFREGAARVISTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2022-12-14" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ00</accession>
    <name>A0A0D2BQ00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233425.1">
        <property type="nucleotide sequence ID" value="XM_016382722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ00"/>
    <dbReference type="GeneID" id="27335479"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08396"/>
    <dbReference type="HOGENOM" id="CLU_2386180_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="94" mass="9849" checksum="17F0A04EE953FFC3" modified="2015-04-29" version="1">MVQCDSAVSITVMLTILDFSAPKLLGSTGQTTRSRAYTWEGIAEERKPVGGVLVPERCLKPIPVTLSDHGLGGSLAAVFFGGRAEVCQSVLVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ42</accession>
    <name>A0A0D2BQ42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233465.1">
        <property type="nucleotide sequence ID" value="XM_016382762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ42"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ42"/>
    <dbReference type="GeneID" id="27335519"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08436"/>
    <dbReference type="HOGENOM" id="CLU_054962_0_0_1"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07739">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="302" mass="34110" checksum="1AF0DE873D326F6A" modified="2015-04-29" version="1">MAPLQCFFRSSSEKGLSSVTTLIVGSKVAILFDPPFLIPDAEAVVKWTKETTPLPVKAVFITHHHPDHYFSANPILEAFPESVLYAAPYVCAGIDREYDDKIKYWPSIFGKDVPEQPRKPTPFTFSFLQLDGDPNSPIVLLGPLQGDSVDHTVFWLPQEKVVICGDSVYARSTHVWVEEIETPQILEAWQKTLDVIESLQPLKIIPGHLEAGWELNAKEDMAHMRRYLNLFSEKITHAPAKPQVKDLYTTFKEAFPQADKNLDFFLGHLSNQFGEGGEVWEENRHHNVGARTKTDLLGFLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ50</accession>
    <name>A0A0D2BQ50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241274.1">
        <property type="nucleotide sequence ID" value="XM_016375998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ50"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ50"/>
    <dbReference type="GeneID" id="27328720"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01637"/>
    <dbReference type="HOGENOM" id="CLU_055668_0_0_1"/>
    <dbReference type="OrthoDB" id="3643156at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="269" mass="29764" checksum="0D837C5DD5CE31B1" modified="2015-04-29" version="1">MVPTETFKIKDASRQAERRRRKSQGLPASPDVGVLADMVSSLRHEAEEHLGHGVPSALAATPNLAALYREDIEDAFEYLSLKFLHNPNPHLPLFREPAAVYAGHGFGICRHPFDSHSCLDELLKMPDTSVLTVLYTRSVLGVEICELASAYRYVPYPTSPTSMDFSLGSDARHDNPDEWYYWQAVRERVLTAIAVNWPNNKPSKLFLMGESAGDLMFRIILEDTVVGALGYNPDAYPGHEVFGAARGAAVLASRGGYFWNSTQSPLILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRH2</accession>
    <name>A0A0D2BRH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ChrR-like cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241889.1">
        <property type="nucleotide sequence ID" value="XM_016376613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRH2"/>
    <dbReference type="GeneID" id="27329336"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02253"/>
    <dbReference type="HOGENOM" id="CLU_093224_0_1_1"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20302">
        <property type="entry name" value="cupin_DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChrR-like cupin" evidence="1">
        <location>
            <begin position="58"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="193" mass="22173" checksum="8FA717EF5741B4FA" modified="2015-04-29" version="1">MSTIITTSPQSALPNLTLANDTAKPVTSETERIKENTERELDIAARKGAPDVYVDAEKDTDWFHWQGTIYVKPLRFENRSGTYVIMLKTAPEAQLGKHRHRGEVRALTVKGSWGYHEYGWTAKAGDYINENPGTIHTLWMGRDSEVMFNVTGSIEFFNDNGELREIMDLFSFWRMYVDHCHKKGVPANENLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BU66</accession>
    <name>A0A0D2BU66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PV08_07604</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235035.1">
        <property type="nucleotide sequence ID" value="XM_016381933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BU66"/>
    <dbReference type="STRING" id="91928.A0A0D2BU66"/>
    <dbReference type="GeneID" id="27334687"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07604"/>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_1"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KIW14819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="365" mass="40982" checksum="082E31238333665A" modified="2015-04-29" version="1">MKERFPPLKNDRLLRAARGEKVDRPPMWVMRQAGRYLPEYHEAKGKHDFFECCRSPEIASTLTLQPIERYAGLIDAAIIFSDILVIPQAMGMEVKMVDGIGPKFPNPLRSPADTQYQEIVKRDVDVAKELDYVYKAITLTRKKLDGRVPLYGFCGAPWTLLCYMVEGGGSKMFREAKTWVYKYGEETKVLLKKISDICVEYLALQVAAGAQILQVFDSWAGELSPASFKEFALPALRYISENLPRRLREMGEDVVPMVVFAKGAWYALDELCDSGYDVVGLDWLHDPAEAVKIARGRVTLQGNADPGVLYGSHEAITSVVESMVKGFGGGQERWIVNLGHGITPGVNPDDLKFFFEEVQRCTTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVN6</accession>
    <name>A0A0D2BVN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235570.1">
        <property type="nucleotide sequence ID" value="XM_016379743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVN6"/>
    <dbReference type="GeneID" id="27332483"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05400"/>
    <dbReference type="HOGENOM" id="CLU_011910_0_0_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="546"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="929"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="937"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="951" mass="105407" checksum="32DA8422D2D3232B" modified="2015-04-29" version="1">MSDQQHRSTGGGGGSTRGGGAARPLSIPDRPRSSSRSQIPARSIESTNTPAPPSTTAQIPGTTVQTSSFRVPQSPKSAIGESSTNSGKVAIPRLKRSIDAVGDEGNRSGGRHRVNHACEPCRHRKTKCSGERPVCRHCQDFKIACFYADGKRDRVRKQFGTMTEKVAEYEKLLKDLLGRVQDEDAQLIRASLESVPYDNEDTATEPGTLTLSAIPSIEKEDSRSGAESDASAGAGSTGALDRTDEDFTREKARTTGYMGKTSEVTWLQRLREENSFGDKPGSVLGDDRQKKLAQASVTSFSSMRPPSDMQVSLAEADDSYAMSDYNYHLDDTSIFTFEAVDPYEMPTPEAAHQLFNAYISRVHPTFPVVGKINLGAQFRKFISGTIQRPPEKWLAIINMIFAIGARYSHLVKADWQGDERDHLIYFTRARLLTMNSETLFQHPDLQQIQVLALMSFYLFCASHVNRAWLLSGVAIRAAVSLGMNLRNDSANLANPLKEIRYRVWWALYCLEHNICNMTGRVSCILDDHCTTPLPVPLEEDKFETEEGVKLLSKESQQGDRAPSSNPQTPTVSNSTPSSERSRSQTKINSRSPSMPTGQGDLEWAKDIPPNNSLYFLHLVQISRLAQDIFHGLYNPTSLTGTWSDVQAKIADLDEQLERWYRKLPQPFAFRRKQRDRESYEHRLNLGFVYYSTKITIHRPCLCRLDRKIPNQSNKSMEFNRNSAASCVKAAMEMLELIPDEPNAVGLLKVGPWWGILHWLVQCTSVLMLEISFRSNHMPEEVDAILEACKKGIRWLHALGEDSASAKRAWAICFPMLQASVKKVGRDVGDVPQQPPGKSDISMQDAMVSGISGYPFAGASGDIFSTAPNVPSMYASGPQAMPQIPTSQAFALYDPMMAFDQYFPAEFPGQAIPFSQARATEMDFMGNAFQDPQQQNFQGGGQSSRGGGPGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZD3</accession>
    <name>A0A0D2BZD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236895.1">
        <property type="nucleotide sequence ID" value="XM_016378218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZD3"/>
    <dbReference type="STRING" id="91928.A0A0D2BZD3"/>
    <dbReference type="GeneID" id="27330950"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03867"/>
    <dbReference type="HOGENOM" id="CLU_007784_3_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="177"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="650" mass="72735" checksum="67EE828B46856B99" modified="2015-04-29" version="1">MAALLTSARYTPLAKSHNNAIRDLLSRHIKLKQHSRNGLPFNESVSQEVTTSYAEIGAPESPDFVVDPDLFRQDMLPSILFDFDNFNPPAFARPHVQSPSDHILPRFSTRLPILDDANYEVKPCDEPSGMFKDAVGVIPWAFSDSVYEGFCLEVESFSAVLPTDWELPSRNSLSRNLESYFRCVQESLPFIHSATFSVAKTDVELLLAAAALGALNRFENHCSYILYFMSKAILAEKMRFQDFDSLDQSVAGRRNGIGKIQTLNLLVSYASWAGKDVLQDGLALATQLSTLVRRHGLSEDEYTSSFGIQIPDNESRDQLWCKWVAAEERRRTLLCAYVLLSLQNIAYNTPPQLLNEEIATLLPSCVDSWKKTTAEALHHPALHHRQYYFKEALSLLSRGIVVPVSSFANYVLILGLLQQIILAHSEARGSSIPHGTLEKFEHALRTWQLSWECTYEATLDPLSEKGPLGLNATALLRLAYIRLNSNMGSWKALSSRDPGDLGIEKMSLERTPQVDRAVLHAAHALSIPVRLGIGLVTHTRLSFRSIEHSLSSLECVWLLKGWLDMISSVVDQCGLEGLRNTERRLLDIITGVIGETSFAETLNTPQDESSRYHRMAIITVQLWAQIFQGVHVLEIDKFIGSGLQLLADTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0L8</accession>
    <name>A0A0D2C0L8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237425.1">
        <property type="nucleotide sequence ID" value="XM_016378748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0L8"/>
    <dbReference type="STRING" id="91928.A0A0D2C0L8"/>
    <dbReference type="GeneID" id="27331483"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04400"/>
    <dbReference type="HOGENOM" id="CLU_1012059_0_0_1"/>
    <dbReference type="OrthoDB" id="3946343at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239413" description="CFEM domain-containing protein" evidence="10">
        <location>
            <begin position="26"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="275" mass="27170" checksum="E8F81C2C8ACA8AF3" modified="2015-04-29" version="1">MKSFVLAAALFASSSFAWLPSCAWSDCTGSWDGTNCDSKSGWDCLCSNQTAISQLNTCVATSCTNQTDQEAIYGAVAQLCANAGVTVTASQEATFSATSGGSAWPSQITAGPGFGPGGNWNSGQWSSWISACSTGLPSAPSGWNGQGGWGGPGMWGGHGGSGGPGGPFGGPWGTKASGINCDSWTTWTAGWGPFSSWTGTWSGCSTTTASPVPATITTTVTTGGSTQVITGTTFGIQAVAAATTTGSSDSGAASVRGLGACGALVAAIFVTMIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C793</accession>
    <name>A0A0D2C793_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239645.1">
        <property type="nucleotide sequence ID" value="XM_016374369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C793"/>
    <dbReference type="STRING" id="91928.A0A0D2C793"/>
    <dbReference type="GeneID" id="27327084"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00001"/>
    <dbReference type="HOGENOM" id="CLU_2171079_0_0_1"/>
    <dbReference type="OrthoDB" id="10019231at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12198" checksum="A42F639BB71088B7" modified="2015-04-29" version="1">MSECCKTGFRWMGTPEGKETKVTFTNARLLADHYAKETDATVYLVDFFSGEVMTPDMMENLKKANAFSVRAFLGRHSKAVRGPKIFAAAKALKQELRYKTVGGIGFCYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8T1</accession>
    <name>A0A0D2C8T1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ZIP Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240165.1">
        <property type="nucleotide sequence ID" value="XM_016374889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C8T1"/>
    <dbReference type="STRING" id="91928.A0A0D2C8T1"/>
    <dbReference type="GeneID" id="27327607"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00524"/>
    <dbReference type="HOGENOM" id="CLU_027089_5_0_1"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002255037" description="ZIP Zinc transporter" evidence="6">
        <location>
            <begin position="20"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="55187" checksum="05BF05A178B136BA" modified="2015-04-29" version="1">MTMLSISVLVLFGVSSVIGQVTYTGCHNHSSVEYCFGPDGEETALATYASAPMVTTFSTSTLPASVSASVTTGQTSAVTGCHAHETNTFCIDGIGNEVQISGTTTATGPPPAQYTDCHSHGDHQYCIGPEGEEVQILAEGAHSESDHDEASGDNADMDCHFHAGVEHCVPKGGSESSSSSSATCELQERDYNIGLRVGTLFVVLVTSAVGVFTPIFMARLPFQSVNSIIFTTVKQFGTGVIISTAFVHLYTHASLMFNNQCLGRLDYEATTSAIVMAGIFLSFLFEYLGHRIILAKSSGNHADAIAYGTTSSLPTKEDGSTPTSAASVQAVNSARGPGVSRSLANLGHNHGSPFDPTNPNSKLSVSIMEAGILFHSILIGLTLVVAGDSFYRTLLAVIVFHQFFEGLALGARIALLPEGMGSFWRTKFPMATAFALITPLGMAIGLGVIHSFNGNDRDTILTIGTLDALSAGILVWVGLVDMWARDWILEGGEMTASDLGYGKIGLGLLSLVAGFIAMSVLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C935</accession>
    <name>A0A0D2C935_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein GOT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240265.1">
        <property type="nucleotide sequence ID" value="XM_016374989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C935"/>
    <dbReference type="STRING" id="91928.A0A0D2C935"/>
    <dbReference type="GeneID" id="27327707"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00624"/>
    <dbReference type="HOGENOM" id="CLU_124519_1_0_1"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15244" checksum="583B4EAC695470ED" modified="2015-04-29" version="1">MPSMWLTDVQKIGVAFCSGGGLFLAGGVLMFFDRSMLAMGNILFLIGLTLIIGIQKTIIFFARRQKLKGTAAFMAGILLILIRWPLTGFLVELYGIFVLFGDFFATIASFAGNIPIVGPYIQMFLQKISSGRRNAELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCC9</accession>
    <name>A0A0D2CCC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241365.1">
        <property type="nucleotide sequence ID" value="XM_016376089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCC9"/>
    <dbReference type="GeneID" id="27328812"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01729"/>
    <dbReference type="HOGENOM" id="CLU_1454429_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="186" mass="21495" checksum="B484C70AF65D9361" modified="2015-04-29" version="1">MSTSTRHRGHSRSSSARQHTSSQAFLRGPFDLTIGNPRHEIEEGEIPQSGFRVNVQWYINELPPADEIATIERIAVVEAKRQGCKVVCIRSNIHDTTRMRVPHSRPARYVHVSDPVGWHYTAEMRLPNGDWLPAHFYTETQVINGTKITRGLDRRLGKNNPIVWTTDYFPHVKGEFRREVYYTVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7T5</accession>
    <name>A0A0D1Y7T5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Type 2A phosphatase activator TIP41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231192.1">
        <property type="nucleotide sequence ID" value="XM_016384590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7T5"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7T5"/>
    <dbReference type="GeneID" id="27337358"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10275"/>
    <dbReference type="HOGENOM" id="CLU_039187_0_1_1"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31690" checksum="C4CC2D39D921106B" modified="2015-04-29" version="1">MAVNDTQSRDAVDTNYPSATTAPPRSFSIEGFRITTQKLPILKAGPIEEMTNKLGIAPPEMIFGDNFVAIEHPSSGWGIKFDAFGALDRVDKTGEKRLKVAYSKEWHQSREDSHDIKEVIKPFDWSYTTDYKGDLSPEGPQFDEGVSPIPLELLKRPDPILFFDDVILYEDELADNGITMLSCKIRVMPARLLLLCRFFMRLDNVLLRLRDTRVYIDFRKKEVLREYVAREESYDKVHNDLAARRDDVAAVLRDANQMPDLLPVVERRLERLELGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y9B9</accession>
    <name>A0A0D1Y9B9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_10867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231782.1">
        <property type="nucleotide sequence ID" value="XM_016385180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y9B9"/>
    <dbReference type="GeneID" id="27337950"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10867"/>
    <dbReference type="HOGENOM" id="CLU_012970_1_0_1"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000335">
        <property type="entry name" value="Siderochrome iron transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF107">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="67309" checksum="3AC7CA8829D51C1B" modified="2015-04-29" version="1">MGFLSKLKPRATRPEVSSASSVPGVQKSDGPLDAPADVSADSDSDGLSLEERNEKEVQRHPNTITEGAQLGVRKAEATALVWPKWAVYATYGWIWVCFFMLALQQGTTTLFNAAAYADFIAAPQLTTANILSTIIGGVLKLPIAKILNIWGRAEGFFLFVCVYLLGMIVLASSTGPSGYAAGYVLYWIGYDAIYLILDVFVADTSGLRNRAFAFAFVGTPFICTAFTAPLLGQAFLKTTTWRWGYGAFCIIMFFVFMPLVLVFKYFQRKAERMGLFKNEASDRSALQSFVHYFHEFDIVGAILLMAAFVLFLLPFSLQTNGKAQYSSATFIAMIVVGVLLFPAFAIWEKFFARVHFVRWELFRQRTVLGACSLAAILYFSFYCWDVYYYSFVLVVYDLSFSDAGYMSQIYNVGSTFWGVVFGFWVRLTKHFKYTCLFFGLPLMFLGAGLMIHFRGTDHGIGYLVMCQIFIAFAGGTLVIGEDMAVMAAADRDGVPMMLSLVNLFASLGGAIGYAVTAAIYDNVFPEALLRRLPASTKGDYETIFLGGYTVQMTYAVDSPTRNAINYAWGETQKYGSVAATAILVLAIPAIAVWKNYNVDKKQNKGTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YC01</accession>
    <name>A0A0D1YC01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232667.1">
        <property type="nucleotide sequence ID" value="XM_016384044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YC01"/>
    <dbReference type="STRING" id="91928.A0A0D1YC01"/>
    <dbReference type="GeneID" id="27336811"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09728"/>
    <dbReference type="HOGENOM" id="CLU_331541_0_0_1"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="95752" checksum="5352100EB41F3360" modified="2015-04-29" version="1">MSTTTRLAHTQRRQGRRVKDFFDDNTFEFAAKSRLPMGFFQDLDVLQDKMEEIRQEPGEEEAGKKEQERSSSRLEEQMQLLNSVRKLESKLAQMKSKLAESTQHTPVRTEPPPRPPEVVLSRDDYKALVDLYFYTNHSRFDPESPDISPTPVLLEDYAFKLSEDFAPPQAFAEFYNDDEDFRSPLKEVEERLLSRQLREVKVTQDFVDLLLDNHSSNAELFKAYKRLPQPGMAFLPRGIIRIFLQRMATPWQKSEKSMIRYLSLIDDAQRADVPVTRAEWASAIYLAGRSFAKVTQSEVNAAFQIWRRMETEAGVKSHHVTLNILFDIAVRANKFPLAQMVLKEMHDRGLRLNRLGRVSVIYYHGLRADGDGVRKAYRDFVDAGEIIDTLVLNCVIASLYNAQEPTAAEQIYERMKSLQQNLRRGKRDDGQTVLYRRYPLPGGEVIEHELAANHLKRVLLNASRLKDILPEHHQQLQDSMPLTPDHVTYRTMISYHVNVSGNLNRITVLLEEMNSLFNLPMQSIFFQLLFKGFAMHGATRDPDASWNNQRLDLVWKACQDAIRAGQAATRGKFSRDTDATLPTSEAIERNLEDTSEHTRPTPLKKLSTWNEFVLDLAVFPRERRKHIERVHAELFDEEEEQKRALFKSSSSSYTSKQSLPHTQETYYPLGEASLDQEEGEYVLPSPSQVIDPAFEQHRQDEPWLDTEQRSDCYGEHEEQRYDGRDQDGDYDHDHDQEQVQDHEVPDERDTKPISITSKHQVQATRPLICWLLRAYTVCTGDRTKVEQVWASVRRLWKTQDPNDRENVSRVLRRCLRDCDRFGPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCJ8</accession>
    <name>A0A0D1YCJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MutS protein homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_09929</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232867.1">
        <property type="nucleotide sequence ID" value="XM_016384244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCJ8"/>
    <dbReference type="STRING" id="91928.A0A0D1YCJ8"/>
    <dbReference type="GeneID" id="27337012"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09929"/>
    <dbReference type="HOGENOM" id="CLU_002472_8_0_1"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001067">
        <property type="entry name" value="DNA mismatch repair protein MSH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="708"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW12651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="894" mass="99739" checksum="FD0A354C556D75B6" modified="2015-04-29" version="1">MTPRQLFYTLPALSQSRSTENLRWPQSDDDYSEHIIMAINVGSKNIIGCAYYIAGEERLLCMEETGGGDHDFVERLKIDIQPTTVILSPRADSLAETTTSGSRRLTSIVDSADDQQPLPYETEIRPPAEFSYEGALDKIISLASPGLCDDSGQFYVPDDPAYHEEDNQLTEIGFTQRRGRLLQLSTRLNLDNRMSIGCAGAVLSYLQRKRSAAYLPDDPRGGQMFRIVRFDMFSLRNTMLVSGDTLASLQLIEPRATGSTWTTGSSKGKGAALSIHALFHVHARSPQGKSFLRQAFLRPSLDVEHINSRLDFVSILLRPENQQQRRDISMSLGKIKNMGNTITLLRKGIERGKQQHNPFKGSVWSSLRDFCSHSMDIAESLRAVIGAERLRLWTRAVELLDRCRLQTIREMVVETVDFEGSADEERTVINRDINPRLDEAKDLYEGLDEILSETATDIVRSIGLEIALGVIYIPHLGFHIRVPLDPTTHEPLFDGSGRDWQQMFTTDNWVCFKDSRMQELDDDIGDQFATICDYEIEIAHNLAQNVLEHEKFLTEASDICGELDCNLAFVHCAYEYRLTRPKITTDNIIDIEGGRHLLQEKSVPSFVPNDTFIVGGGGEDEQAPVGPSMLLLTGPNYSGKSVYQKQVALAVYMAHIGSFVPAESATIGITDKILTRLTTRETVSKVQSAFMIDLQQIAMALNSCTRRSLVVIDEFGKGTDTCDGAGLAAGVLLYLLSLDTQAPKSLVATHFHEIFDTISFETWENVFYAHMEVQVENTDVRGTVQHSSVTYLYNLQRGRSDLSYGTQCAAMNGIPEQVVERALQLCRLARKGEDLVTQCSRLTVSEAAELETAEVAAELLMDQNFDQQMTEIGLRALLNALVEPASNDSEELDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YEV7</accession>
    <name>A0A0D1YEV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CDP-diacylglycerol-inositol 3-phosphatidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233807.1">
        <property type="nucleotide sequence ID" value="XM_016383104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YEV7"/>
    <dbReference type="STRING" id="91928.A0A0D1YEV7"/>
    <dbReference type="GeneID" id="27335863"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08780"/>
    <dbReference type="HOGENOM" id="CLU_067602_0_1_1"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33451" checksum="4B13C6C798E82DAA" modified="2015-04-29" version="1">MARKAEKRQSSPNGHVLHKGEEAKVNGVLERLESDIYEEENIFLFIPNIIGYARIILAVASLYYMPLHPRTCSFLYSFSCILDAADGMAARRYNQGTTFGAVLDMVTDRCTTSCLLVFLASAFPRWSIIFQGLISLDLASHYIHMYATLTMAGSGQSHKKVDSSRSWILHLYYTNRAVLFAFCALNELFFIALYLLSFSSPYLSPSLLITNSNGTGVSSTQPGSPVHPKPSTLFANPWSAGALELARANKMDSTVPWILAGASFPVMAGKQIINVIQLVKASKWLGEGDIAARRKAGIAKKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YGD1</accession>
    <name>A0A0D1YGD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234257.1">
        <property type="nucleotide sequence ID" value="XM_016381155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YGD1"/>
    <dbReference type="STRING" id="91928.A0A0D1YGD1"/>
    <dbReference type="GeneID" id="27333905"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06822"/>
    <dbReference type="HOGENOM" id="CLU_018687_4_0_1"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="285"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="620" mass="69755" checksum="B28725CBE6628FB5" modified="2015-04-29" version="1">MAQKKPGLQEMVQVDRSEYGQFARRQIMLTSGRRPSSPFWRSRSSSRQASGKSNKVIGASYSHADMFKFDSLSIGSGSNPRSPPNHPSRSSHTSPADGRGYHEQERKAYPGYTSSVLSESWDVVGDGDVEADDDDLVYEDDEDEFGLPSIASMRRKRSIKNKALKAQHVTYPSIHQTSSGATLAPSPMPQLHRSSSFDIAEERNPLSYPSAKKGDGKILRPQYKDILRDPANSLHLINHPVLASNATPKETEAHSTRISRINKFKRILQASSVSLPDLRSAAWSGVPEEVRAITWQILLGHLPTNSERRVTTLERKRKEYLDAVRQAFNSGSVGNRNGSSTGLTGLGSQPPVTTGRGRGLDEAVWHQISIDVPRTNPHIPLYQYEATQRSLERILYVWAIRHPASGYVQGINDLATPFWQVFLGTYITDLDIESGMDPGQLPRPVIDAVEADTFWCLTKLLDGIQDNYIVAQPGIHRQVAALRDLTTRIDSGLASHFESEHVEYMQFSFRWMNCLLMRELSIKNVIRMWDTYMAEENGFSQFHLYVCAAFLVKWSDQLMKMNFQEILMFLQALPTREWNEKDIELLLSEAFIWQSLFRGSRAHLRTSNSTIPMGSLGPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YH43</accession>
    <name>A0A0D1YH43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234502.1">
        <property type="nucleotide sequence ID" value="XM_016381400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YH43"/>
    <dbReference type="STRING" id="91928.A0A0D1YH43"/>
    <dbReference type="GeneID" id="27334151"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07068"/>
    <dbReference type="HOGENOM" id="CLU_096188_0_1_1"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF3">
        <property type="entry name" value="CUPIN 2 CONSERVED BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="91"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="188" mass="20555" checksum="FC0D16B04CA14F30" modified="2015-04-29" version="1">MAASRPLLDNNLPTIDRFVTDHGGDGKAVFSQAIPENLQFQELADGARFCLGYTTRKTPVDMSDGKDLSDYQRDLDNKPGIMIPGGTVLRIVDMRPGALSPMHRTVSLDYGVVLEGEVELVLDSGEKRLMRRGDVAVQRGTNHAWKNASSTEWARMLYVLQEAQPISVGSKVLGEDYGGMPGVRPSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YHD3</accession>
    <name>A0A0D1YHD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_07133</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234567.1">
        <property type="nucleotide sequence ID" value="XM_016381465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YHD3"/>
    <dbReference type="STRING" id="91928.A0A0D1YHD3"/>
    <dbReference type="GeneID" id="27334216"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07133"/>
    <dbReference type="HOGENOM" id="CLU_034765_3_0_1"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000043">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="75"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="283"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW14351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="385" mass="42311" checksum="931F7B488308462A" modified="2015-04-29" version="1">MKRLRLLRWSGSVLSPRTRPEPLHSHICHFRRCQTTVTDISGPGDYLEGAPIFSEDVLVKLPSPPVTAAKTSAKLAALHARLALPTRLPLETLARTLVDDSADPSIRFNNKPFAVLGNDLLGYYTSENILAQYPRLPMAVVFAAMYAYHGPATLSSLAREWGVESAAEPGGEVDPGLLQFKRLPPEPKPQRPSLQVIEAYQDGEKFRRTMNSRTVYDDQFGERPASQEVTQKGVTLERASTNFVRAVFGAVYLHAGRAAAKQFYNDHIASRQVNMASLFQFKNPTRDLSRLCAREGFQAPVAKILSETGRKSRTPVFVVGIYSGSEKLGEGAGASLIEARTRAAVAAMKGWYLYSPTEVRLPSEMEEPGAKAWTPVLIDAGEIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YHM2</accession>
    <name>A0A0D1YHM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234637.1">
        <property type="nucleotide sequence ID" value="XM_016381535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YHM2"/>
    <dbReference type="STRING" id="91928.A0A0D1YHM2"/>
    <dbReference type="GeneID" id="27334287"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07204"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF5">
        <property type="entry name" value="GENERAL AMIDASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="81"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="234"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="533" mass="58386" checksum="C034412225F8512D" modified="2015-04-29" version="1">MVRDWKELVAQKRADVAKQLPQEWRLPQAILDTVSAAADISVLDVPTKCGLLTSKELEITEKYDAVDLIAKMASKDLSASEVTLAFCKRAAVAHQVTNCLTEMFFDKALERAKYLDEYLQKEGKPMGPLHGMPISLKDSFNLKGIHATIGYVSFIERPAADTNSPLVDILLANGAVLYVKTNIPQTLMTADSENNVFGRTLNPHKLKLTAGGSSGGEGALVAMRGSILGVGTDIGGSIRIPAFCCGTYGFKPSVNRIPFGGQVSPVADGLPGIMPVAGPLAHSPRDLRLFLETVIQSKPWDFDYTALAIPWHPVPEPKSLTIGVVLQCPTWKITPPMLRTMKTAVEKLKQAGHNMVMLEKFPSFKAATDLSWDMFDIDNEGTGFKNIQASGEPLVTSVADLYTPPPGGRKDKTLDDLFKMNIKQLEFRRDWLRVFMENKLDVILAPGSHKTAVPHDTFRYPPYTVMWNLLAYPACIIPFLKADQTVDKPDAEVPDYDPQAVDGAPCHVQLVARSEQDEELMAAVELAAKALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKU8</accession>
    <name>A0A0D1YKU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235857.1">
        <property type="nucleotide sequence ID" value="XM_016380030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKU8"/>
    <dbReference type="STRING" id="91928.A0A0D1YKU8"/>
    <dbReference type="GeneID" id="27332773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05690"/>
    <dbReference type="HOGENOM" id="CLU_1085998_0_0_1"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28866" checksum="9B81A041806BDC81" modified="2015-04-29" version="1">MEEARSSKEYQLEERTTNSTEPLMGSSHRSVHMDDNGSDFNQLAGRPKPWNIFGRTAPVAVLFVAVVEGVALLLLSMSSTPARTSFTFNEVATTSFSEAVKYTKGVRPPMFGPEFPRKTVTFIKDPRFMGPPAHVHNAWAPYLDEGIFAAMSFKWDSGRGYGVSGYHQFHCVWMFLQAVYMAKNGTKPPKDFEGHALHCVEYLRQSTICNADNTIERSYQGVFGTFEANNTHVCRDWDALMGWAHENVYVEQETDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YLB4</accession>
    <name>A0A0D1YLB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236047.1">
        <property type="nucleotide sequence ID" value="XM_016380220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YLB4"/>
    <dbReference type="STRING" id="91928.A0A0D1YLB4"/>
    <dbReference type="GeneID" id="27332964"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05881"/>
    <dbReference type="HOGENOM" id="CLU_029628_0_0_1"/>
    <dbReference type="OrthoDB" id="5430106at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794">
        <property type="entry name" value="THAP DOMAIN PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794:SF2">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="579" mass="62509" checksum="B0CB5D1B04A21554" modified="2015-04-29" version="1">MPSASPSPMKRPSLNERTLSTQSLSSSGKQATGHKVHRPQKVTRHSRNVSHGKGLSKLGRNHSTAAILTDHHHHRKKSSGTTPPQSPKTPLVKRNSSHAALPKNQSHGNLRKNQSANALARNLSHPALKKIGLAPAPKQKTKKKDGVFQLGDHSSDEEEAEWEDSNTQSPEMTRNNSKTSTPLKVGTPDDEEVTDNGMEASMARHTRRTSSPPAPSLRTNNRSAPNLRKDSNMSPPQLAPDPALLHQQHRASRAPPAMSTVSALAGPSQLLRSESSKSFTHITHGEAASTHTLPGMSGSGQAAASSSADGGVSHFLSESAAPSRQQVIDESDDDSPSTFMDNYKPQPSESPEKTRTLHKVRLPTHPSRTQQKLELQRREIMRASAATPTTPPAHGMGLSIGSSTSLHSRTSSRNRNRSLAGGRGLAGDLKAIQKDYESAVKQITVVRKFRSPIIESMLRLKEDNALPAELGQGSSAIPTSKSRPASRRGPGTTTINGRSLEDKKPALVSRSSHRTSQSGRVHFQRQSSHENIGVTPSQGSPDDDGRDDEHGLSPEEALLRRIWESRGFYEAGDVAPPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPG9</accession>
    <name>A0A0D1YPG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_04262</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237287.1">
        <property type="nucleotide sequence ID" value="XM_016378610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPG9"/>
    <dbReference type="STRING" id="91928.A0A0D1YPG9"/>
    <dbReference type="GeneID" id="27331345"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04262"/>
    <dbReference type="HOGENOM" id="CLU_032441_0_1_1"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="14" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 17" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW17071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="357" mass="38922" checksum="3792006FA3433BAE" modified="2015-04-29" version="1">MAAKDVWEIWPLARSMGVWQGGLGLLPEELVLIFVSLCIQAQVIANSGHDDMIHDAVLDYYGRRLATCSSDKTIKIFEIDGDQHRLTETLKGHEGAVWCVSWAHPKFGTLLASSSYDGRVHIYRETPSQQPNGPAQWTLVFTSTIHTASVNMVSWAPPELGCLLACASSDGNVSVLEFRDNQWAHVIFPAHTMGVNAVSWSPVGAPGAITRKDGGGSSTSSASASASPVRRFVTGGSDNSVKVWEFNAQSQTYETSVVLPNGHVDWVRDVSWSPTLLSKSYIASASQDKTVKIWTSVNPADAASWTLAKTLEFDAVLWRVSWSLSGNVLAVSGGDNKVTLWKEDLKGNWEMVREVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPQ5</accession>
    <name>A0A0D1YPQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_04387</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 14"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237412.1">
        <property type="nucleotide sequence ID" value="XM_016378735.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1YPQ5"/>
    <dbReference type="GeneID" id="27331470"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04387"/>
    <dbReference type="HOGENOM" id="CLU_000914_2_0_1"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="17">
        <location>
            <begin position="252"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="16">
        <location>
            <begin position="479"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="147"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="640"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="809"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1156"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1444"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="658"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="833"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1156"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1444"/>
            <end position="1456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW17196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1489" mass="163761" checksum="0C1847160DE24E09" modified="2015-04-29" version="1">MEQGSPLHRTSTNNSESALDDTSSLTAVYSGSSSVTSSRPPVSLGRPPSTHSLLASHKNPEVRKAPQAETTKASADRSSISMPPPSSAPTINRRLSTSLNSLRSQRKSQDDARSPPASVKSLDAPILATSPTTIQVPTTAYDPTVVTTASTSTSPGAPVLSPPVFDPSMSNPSDLVSSQATLAPSGTKSESSIPAGQTLGSASKTDGSETVLPNRAPRVTKPRSISSSRRLSGTGSSKNDAGSTESKISMGKIGVCALDVKARSRPSRQILTRLQGNGDFEVIVFGDKAILDEDVENWPICDFLISFFSDGFPLDKAIAYVKLRKPFVVNDLPMQKVLWDRRLCLKILDQMQIPTPRRIEVNRDGGPRLESAELAQHVYNMTGVVLEGPEDGTGGGAPPAKSVELTDEGDTIIVDGRSLKKPFVEKPVNGEDHNVIIYFPRSQEGGARRLFRKIGNKSSEYDPDLVVPRSITEPGSSYIYEQFLRTENAEDVKAYTVGPDYCHAETRKSPVVDGLVRRNTHGKELRYVTKLTDAEREMAAKVARAFGQRICGFDLLRTGTSSYIIDVNGWSFVKDNEDYYNDCAKILRGMFVTEKLKLENGWTEEPSPESNGELPLRRQGTNHPHRSALKTILKSPSMNKLSQHLPHSNRHHQSTAGPSSRSSTLTTPLSSPPTMEKSSNAQVMPRAVDNPEMLPPPAVHTASVGPAAGELMTPAKEPEAQAPMPSSKHSWKLKGFVTVIRHADRTPKQKIKFTAHSQVFADLLKGHHEEVLLKGEAALASVEAAVRTAQKDHLEDPDKLRNLRVALAKKGSQPGTKVQIKPMFRKRKPEEMQANSMDPTNPSSPSVLSIPETEPFQIHDSPLADRSGSIPDLKDPNQLHRPQTRSDSMSGATFSRFSAAENDLVLDKLQLVMKWGGEPTHSARYQSQDLGANMRDDFKLLNREVLNDVRLFTSSEKRVKTSAQIFAAAFLDRQDIPEDFIQVRKDLLDDSNAAKDVMDKVKKKLKHLLREGSVPEAFAWPKDVASPFVVMQNVIDLLKFHRKVMRHNFKKLTSGAVASLAAINGGSESKDSSKEGVSVASIQSRWCTGEDPELFKERWEKLFSEFCDTEKADPSKISELYDTMKYDALHNKQFLEWVFTPSQSLLDDLAKEENLAASTSPVEQEQIEGSVSPSSKSRQESTASVAGSLSDKHSFAHKIGLRRQSILKQPVAAPPLNSWEQGASYFKLFSGSSESKSSLDQRLGRLRELYRYSKILFDYIGPQEYGISDEEKLEIGLLTSLPLLREIVDDLEELQASSDAKSFIYFTKESHIYTLLNCIMEGGIHTKIKRSTIPELDYLSQICFELYEAKDADTAESTYSIRISISPGCHTIDPLDISLDSKHAIGSAPRRSLTNHQDWKEVISTLKAKFNTVQLPKSFLAVNVSDKHEQEAERRASYLQSEAARVKHERGEHEEATVIGSQDNSAPGEEAVTSGDVTGPDSVAITRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQB8</accession>
    <name>A0A0D1YQB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237652.1">
        <property type="nucleotide sequence ID" value="XM_016378975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YQB8"/>
    <dbReference type="STRING" id="91928.A0A0D1YQB8"/>
    <dbReference type="GeneID" id="27331713"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04630"/>
    <dbReference type="HOGENOM" id="CLU_044118_1_2_1"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000019">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF39">
        <property type="entry name" value="PROTEIN QUTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="348" mass="38021" checksum="9B184FC29D1765A7" modified="2015-04-29" version="1">MAGSDQYDVSDTELTEIYAFAIQLGKDAGAILLDSLHQRRHDGAEDAGTQGSKVPEELVMEEKLNSVDIVTKTDNEVEEFIHSSIHKRYPSHSFIGEETYSKGSSKEYLVKNDPTWIVDPLDGTVNFTHCFPMFCVSIALVVNQKPVIGVICAPLLNQTFSACRGKGAWLNETTKLPLLGSRGVGPIPKNAPSKCIFSCEWGKDRRDRPDGNLHRKVDSFINMAAEIGGRDGKGGMVHGVRSLGSATLDLAYTAMGAFDIWWEGGCWEWDVAAGICLLEEAGGLITTANPPENVDTAKIEEAGLGGRLYLAIRPAADTAGETGREGQERLVREVWRRVRHLDYSRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRN6</accession>
    <name>A0A0D1YRN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238122.1">
        <property type="nucleotide sequence ID" value="XM_016379445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRN6"/>
    <dbReference type="STRING" id="91928.A0A0D1YRN6"/>
    <dbReference type="GeneID" id="27332184"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05101"/>
    <dbReference type="HOGENOM" id="CLU_013866_5_3_1"/>
    <dbReference type="OrthoDB" id="5429770at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="509" mass="55901" checksum="FB04EC97991E0DE3" modified="2015-04-29" version="1">MTYCGRPSTACHACRQKRGKCDRRKPGCGQCARKRISCPGYRDPDTIVVRDQTVSTIRRFRAKRDRLTKELTPHESAILPPVHEHPTKPTKPTTTPPDSLSFGLAIAPAPEDAASAFFLFCYAPAGPMACLPILANVCSPADVLLMPALLAPALAILSFEFKQPSLMKLARKNYATALKEVNLALASPTHVANDSTLASVLLLALFEAVAFQRSDSLNSWTVHVNGAAELLKVRGPSQFESALGRALFLDVSNGIYASCAQRRIATPAAISELWVHWRKIAGDDGPEVGMGRVSDAMANLLARMTASGEESLGNEGVVREGLELDALLVHLLEQLEEISPYQTLPPVEVPTLAYNNVAHNYKSPQAARHWNVLRMMRMFVNKWVYRAASAMQDVSIGGVGSEEVILPERLLEMTARNSETMAFDVLSSVPFFQCLPSWRHSNQSMARWLIWPLSAVAVSMFVPVSAQMYARNSLQAIVKDSGLSQAAEALDMVDERRSLENWLHLCHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSB2</accession>
    <name>A0A0D1YSB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phenylacetate 2-hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02414</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238342.1">
        <property type="nucleotide sequence ID" value="XM_016376772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YSB2"/>
    <dbReference type="STRING" id="91928.A0A0D1YSB2"/>
    <dbReference type="GeneID" id="27329497"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02414"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_4_1"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW18126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="61912" checksum="D82D6A8BB5FBBB21" modified="2015-04-29" version="1">MAPTVSGLLQVVNHDYTIWISGTILIIFGLYWWSTLTDIPKIKGIPEIPGALPVFGHLLQLGPDHATVCEGWWRKYRQSVFQIRLGNTRAVVVNSFEDAKQMLIGHQTAVIDRPTLYTFHGVISSTQGFTIGSSPWDNSCKNKRKAAGQALGRPAMRGYFDMFDLESYCIVRDLFRDSHNGATEIGVRPYIQRYALNTTLTLCYGIRMDNVYDDMLREILHVGSAISLLRSASENFQDYVPVLRYFPNNEKNRRSKELRDRRDAYLNFLLDKVRDMIAKGTDKPCISAAILKDEETKLTGVEVSSICLSLVSGGFETIPGTLTSCIGSLSTKEGQVFQDRAYADILRHYPSGPKAVWEHSFQEEKVPYVNAIIKEAARYYTVSAMSLPRKTVTEVDWNGAKIPAKTMILINAQAANHDVDHFGPDGAVFNPERWLNDDFVMNPAVGAPEEKPAQGIQHFSFGAGSRACSGQFIASRLLYTALIRLLTCYKIVASDEEPPNTDYVDYNQFKSALVAIPRDFKVKLVPRHDESVIKELMADTAERTKDYYAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YTS8</accession>
    <name>A0A0D1YTS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_02950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238877.1">
        <property type="nucleotide sequence ID" value="XM_016377307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YTS8"/>
    <dbReference type="GeneID" id="27330033"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02950"/>
    <dbReference type="HOGENOM" id="CLU_1229951_0_0_1"/>
    <dbReference type="OrthoDB" id="3647246at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="225" mass="25480" checksum="40FDC6CCBB688E48" modified="2015-04-29" version="1">MPGRATFMSPPSVLEYARFHGLALDYRSSDPFAYLNTLEPNGQIVEVDPALSDPVFLFLKPISQESKLQLSREASQILSDSIKDPCSDISSQHLVPRFRRLKNLKLEEPLLSTDHQTDVWNFKRSTPVGVQLRSILLRAEPFQLPGSGQLVDEFNHVFRGRTHGKFEQVGQERLLISRGTLSRISKVCLDDWNEMDKYDDLMVRLDLKKVSGAILADVEITGNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YTY2</accession>
    <name>A0A0D1YTY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238937.1">
        <property type="nucleotide sequence ID" value="XM_016377367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YTY2"/>
    <dbReference type="GeneID" id="27330093"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03010"/>
    <dbReference type="HOGENOM" id="CLU_1115771_0_0_1"/>
    <dbReference type="OrthoDB" id="5243686at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="255" mass="29325" checksum="678CF9E5B963FD0D" modified="2015-04-29" version="1">MAQNPPFFQPFLFCVSEVTIHNNPQRAGRSTPNDRYWVPPADKEEFSKQQPPQWRVWNPGQRQSLHGFRHLHRPTTETIRDFRHTRTCSVFWDPERHGYVLVPYDCTRISDCETSPFNWRRLSFGQNNTHPDRRIALVGYEMTSHNLPFAGPQSWFDQLLSDVYRGQGAGNGHNCGLAGNLAVLIALIAFSANRGDAYAAVDQSFRPDISSTTLRPHGHPVSHRNLRRGIIVEIRVQDETVLRNWEMGMYGPIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUK5</accession>
    <name>A0A0D1YUK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239152.1">
        <property type="nucleotide sequence ID" value="XM_016377582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUK5"/>
    <dbReference type="STRING" id="91928.A0A0D1YUK5"/>
    <dbReference type="GeneID" id="27330308"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03225"/>
    <dbReference type="HOGENOM" id="CLU_019096_1_0_1"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="111"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="574"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW18936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="749" mass="81034" checksum="1F1EE39B8C9B8A5D" modified="2015-04-29" version="1">MDDSSDSGSPVSEHPPASLYEQSPPQSSQQPILLPSTLQPRLPTVTEEEDSPHIETSLPASEESPPPPSQQPSPPISDEPPTVTVPPDHVNLRVVYLVTGNPRPPHSLGVLPVSTTVSALREQIQSELPEHPSPERQRLIYQGRPLLRGDATLREIFRIQAGSTPGPLPHTLHIVIQPQTDAVPTVAVSNPAEPLNQRTAQRTGPMPVGGQLALERVQAHLAAIQQHFETNRADLHNVQPSVATQHHTMAVHVDGPVHVPVINPGGILPPLPGAIPAQIAQFRQPAFRGHQTGPDAWTVTANTTANVNNIPQQTLPAFRRVVMPNGQQRTEVRNPTTTQASRDPPGVSGPARSTQPPTIQQAAPSNPPEANATQLQAGSIHLPNLIGHLPQPFNQTRSSIRRNLPPNGTAWLLMTSTGPRGFLFAPGFGFFSSYRDPSEMPAVNAQATQSESTAQTEGVMQQQPLGEMGAANADIDGAIIRPAQGPAQGPAQGGAPQPQVAQAVRNAEDNDLFAFLIQRGWLLLRLYLFMFVFSEPGTWKRWAMMLIAVVVCLQPRNGPFVRAMRAARQHLDNLIGPQAPQPQPDAAAPRQARPADPTNQGPSRPANIRGAVQMTPEEAAARLLRERAERNRGFWRESLHRVEQSIALFLASLIPGVGERHIMAREEARRQAQRDEEERRRTEEEASAAAGHRAEETTESAQTSEAVAETGLGAQTEAKVDRPEGSSSSSSIQVRDAGAEDGELRNRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YV83</accession>
    <name>A0A0D1YV83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239417.1">
        <property type="nucleotide sequence ID" value="XM_016377847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YV83"/>
    <dbReference type="GeneID" id="27330578"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03495"/>
    <dbReference type="HOGENOM" id="CLU_463095_0_0_1"/>
    <dbReference type="OrthoDB" id="4159241at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="589" mass="65108" checksum="03597EE048F85011" modified="2015-04-29" version="1">MWRARSRGRNRRGATVTPQNTQSPWKPVVDLTGDTLPVSASAPTPRVAPPLAPASGSGYKTNNATTIEAPLDPKQSPAYLLQQMALLGNRARVRPSFSSKVRPGLSDSGTSSELGPEDKENTPTPHSNTRIIRPNDNKSEKKSRAGGSLSSFPIVSSDDHQDKTRVNSKAAASKRDTSVEVVFQETRKKTDDRRARARSSESRTGGQDQDENDNHENTSNVTAGVEADDGPERPRKKPKSKTKSKKKKSTTTTTTKKKNKHDNSGQQGEEGENTHVNVEAESESGTVGNKNKDNTGKSKKRKRDRRKSRGESEGEAEAQAERQEKGEIVSSAEAKALKQLREILPSKRVSRVETQLRLEMAAWGCEPTETTVLVTTARDTVIDLARQQVVQTERSYQAIQAELLRMLKEQNKKLRRWERRAKTTNATNTSSTPAADTTPHVSESGIGTCRSGSEVRSTGTSAVVCSSSEDKSGSDSEQEEADAEEEEEQSDEEEEEEADDDDEKSEEQSDDEDEEMDKEEEKDASPRRKKQKRSHGHDRHGHHALRNRRSTQRSGHRIRLSPVSPVSHRRRAATEDPQPRASTCQGSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWE4</accession>
    <name>A0A0D1YWE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239817.1">
        <property type="nucleotide sequence ID" value="XM_016374541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWE4"/>
    <dbReference type="STRING" id="91928.A0A0D1YWE4"/>
    <dbReference type="GeneID" id="27327257"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00174"/>
    <dbReference type="HOGENOM" id="CLU_021695_0_1_1"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="467" mass="51899" checksum="949B7DDE0EB6722C" modified="2015-04-29" version="1">MDEIAPEYDVIVLGTGLTECVLSGVLSVKGKKVLHIDRNDHYGGEAASVNIEALFKKYGNFQEGQEPWKKYGRINDWNIDLVPKLLMANGELTNILVSTDVTRYLEFKQIAGSFVQQGSGPRATVAKVPSTAAEALSSPLMGLFEKRRAKKFLEWVGSFEENNPATHNGLNLNKCTMREVYDKFGLEATTRDFIGHSMALYPTDDYIDAPGQGKETVERIRLYANSMARYGKSPYIYPLYGLGELPQGFARLSAIYGGTYMLNTSVDEIQYEGGRVSGIKATMRERGDDGEGMKFSTKTKMILGDPSYFPDKVQVVGHLLKAICILNHPLDKTADSDSLQLIIPQSQVGRKHDIYIAMVSSAHNVCPKGYYIAIVSTIAETSANHHLELQPGLERLGRIEEKFMGPPIPLYQPLESGVNDQIFISNSFDASSHFETVTENVRDIYRRAMGEELKVEGLREGQTLAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXN9</accession>
    <name>A0A0D1YXN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240232.1">
        <property type="nucleotide sequence ID" value="XM_016374956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXN9"/>
    <dbReference type="STRING" id="91928.A0A0D1YXN9"/>
    <dbReference type="GeneID" id="27327674"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00591"/>
    <dbReference type="HOGENOM" id="CLU_013539_1_0_1"/>
    <dbReference type="OrthoDB" id="3344043at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW20016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="596" mass="65610" checksum="8EE9A2A08964FF71" modified="2015-04-29" version="1">MPSTRGDIPDIISLSSTTLRRFAGAKVDPYVRYVAFLLLRDLKIGIAGQRNMNNALSNLPVHLSVAPADKLCFGWGPSHVIYDRAVHEDEGSYDHLAVMLALTETFRETYGALVLMEMSSAAAGAAAGPDDFTPHFAQWKAALHGCNGALASTDFGLLVEDYIQLYPYTIVNLGRLESLIPPKVVAEALSALLEVTSGRQSKVTFTGSAVTGWIGALAEWLCDLPLAVYQTGGQQLRRTHTDKEPQITLVFVEKPGLTFSFEKRDLGSPRIADLSLVDRTYSSAVHATPFGGRVAWQSLLPRVFGKSFHYLDHDESRAFATMMGSAAKMFEGLALGRGHEEHNDLVSTQNQNNSASYGAGLIVTLTNWLPELRRFEGRMEKQLKSSHENAAATYVEQLTRIRKACHCGICTAKEHLVDGQDGVPPSHGYCLAVLVETIIALGLSLSRMTVAPRLYPTRSGIQSFYLGQVSKRLEARGMHWKEHFKIVYGNEWNAPDARRLQNAIQVFTGSRPTTNIPENLVAISHEGICAYFVAMEKGYSSENVQQVQLIRVVSGSINVGEKLFDRASLGALTRADPDDPWEELNYDHLPKPVFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXR1</accession>
    <name>A0A0D1YXR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240267.1">
        <property type="nucleotide sequence ID" value="XM_016374991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXR1"/>
    <dbReference type="GeneID" id="27327709"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00626"/>
    <dbReference type="HOGENOM" id="CLU_001265_2_0_1"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF104">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="90"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="549" mass="62720" checksum="6B2312D1454F9984" modified="2015-04-29" version="1">MARTSFNAGPSGLELDHDLKKETVRDMGPVEDCSSSEGSSYAEDKTFIHVDGEDTYVPIDKYEGRHRWDPEFEWDPAEEKKLVRKIDLRICTWVCLTFFALQLDRANIVQALSDNLLEDLNLNTNDYNYGQTIFYVCFLSAELPSQLISKKLGPDRWIPIQMISWSIVASCQAFLSGKSSFYACRALLGLNEGGFIPDTILYLSYWYKGRELPARLAWFWTSYQATSIVGAFLAAAILTMRGVNGLAGWRWLFALEGTLTGLIGIATYFYMPPSPCQTASRFRGKDGWFSVREEKIMVNRILRDDPSKGDMHNRQAVTPKLLYYAMCDWEMWPIYLIGLSFLIVNYPATQYLSLILKQSFGRFEVNMLTIPSYVLFIINLLFWTWVSEKTNQRFLTGLVSQIWAMPLLIASELLPAGASRWVKYTLVTLLVGTPYVHAIHVAITSRNAGSVRTRTVASALYNMFVQASNIIGSNIYRNNDKPMYRTGNKILIAICAYNMLLFLGAKGFYVWRNKVRDLRWNSMTSAQQREYLATTTDKGNKMLTFRFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYN2</accession>
    <name>A0A0D1YYN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240612.1">
        <property type="nucleotide sequence ID" value="XM_016375336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYN2"/>
    <dbReference type="GeneID" id="27328054"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00971"/>
    <dbReference type="HOGENOM" id="CLU_1299724_0_0_1"/>
    <dbReference type="OrthoDB" id="10639665at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252272" evidence="2">
        <location>
            <begin position="27"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="212" mass="23765" checksum="26A33BCC4EDD1ACD" modified="2015-04-29" version="1">MAVHSKSAIPLFIFLALLLLLLPCAAILWHGKRKFREQRRRRRSRQKTVQKIIHTMSTPIEMGKIRTPTVGVAPWRERIQARKLPLAWRGPDGKFIIPNQASNGQPSPSQGARISVEEGQPSIPSPRSTPHFNTPGEPLLPTQFATVVDLESQPFDLKPAPQFKKKQSHARVHKAPQRKAGLAEAPHVDSQYGIPGDNVEYDTQAQTQKDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0T1</accession>
    <name>A0A0D1Z0T1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_01821</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241457.1">
        <property type="nucleotide sequence ID" value="XM_016376181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0T1"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0T1"/>
    <dbReference type="GeneID" id="27328904"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01821"/>
    <dbReference type="HOGENOM" id="CLU_063514_1_2_1"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="38"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW21241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="309" mass="32834" checksum="7D2DC623098E28A4" modified="2015-04-29" version="1">MSDRRRVNGPAGTTSPPVFVASSQTVEAEKKRLRAHNELRKIFLQTGVVPSASGSAYLELESQPVKPTLVSLSSTIKLSCSVQGPKPLPRTASFSPNLQLSASVKFAPFATRNRRGYVRDSTEKDLGLHLQNALKGVVIPDRWPKSSLDIAVTVLEGEDDQETGDRISGLGLYNMLAGCINVAMAALADARVDCLDLLAAGVGAIVSGADGKPVKVLDPAAIEHKKVVSSCLVGYLPTRDEIVELWCSDSGSSQGKEDAGFEELVDSAVAAARGAQTVLKEVLLESMMRNQVTTKKLTGQTAKDVEMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZB17</accession>
    <name>A0A0D1ZB17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial protein Fmp25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230423.1">
        <property type="nucleotide sequence ID" value="XM_016385479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZB17"/>
    <dbReference type="STRING" id="91928.A0A0D1ZB17"/>
    <dbReference type="GeneID" id="27338251"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11168"/>
    <dbReference type="HOGENOM" id="CLU_021989_1_0_1"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000027">
        <property type="entry name" value="Protein FMP25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="281"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="345"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="64999" checksum="A3C978ACF870F46F" modified="2015-04-29" version="1">MVSTKLNTNAARSLARSQRSRITQARSRVQLYNPRHHIHNYSATHRAWKRPSAAIFAVVASIALVYSASQPKHIQAEAPAQEPPELVIEKLKKKKGASKEEIRDLISSQHLQVKKSWENPGVYAWGSNTGRVVAPDSDEAYVKIPRRIPFFDDVLLRDLKLDRDFGAAVLENGDLVQWGKGYSEDNVQPTVTLKGKNLSSIVLSRDRIIGLGKNGIVYSVPVSKLDQEIGKKMSERSWIPFWTTTSDIAYRKLTPKGLGALEKVTAISGGLEHVLLLTNSGRVFSAASGTEDFPSRGQLGVPGLTWLTRPEGAYDMCHELTTLKGFDITKLASGDTHSLVLDKEGRVFAFGDNSSGQLGFDYNPEAPYIDTPSLLPISKYYQGTNQVPKVTSISAGGRNSFFTIDATRVVGPSEDPSEVRNLGRVTSDTWSCGTGIRGALGNGRWTHIQDGLTKVPALSGLFEYDERTNSVIPIRMAQISVGATHVSAVMDNVTYLDASDKSSENDTNWGADVLWWGGNEFYQLGTGKRNNVPNPIYIKPLDSAAEIQAGRKEEHRFHLTPKHSVQVKGRKVQLEQRVECGRNVTAVYSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZEG1</accession>
    <name>A0A0D1ZEG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231593.1">
        <property type="nucleotide sequence ID" value="XM_016384991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZEG1"/>
    <dbReference type="GeneID" id="27337760"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10677"/>
    <dbReference type="HOGENOM" id="CLU_062486_0_0_1"/>
    <dbReference type="OrthoDB" id="4161485at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002247770" evidence="2">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="278" mass="31125" checksum="AF278E0CC55F1898" modified="2015-04-29" version="1">MCNLFLPLCPFVLHSIATGQGQRPANDGPDAKILFSYLSRNPYKNSSDPDQAQLKPLALKTAKLYKRTSWHTCPCFFQTVSVLHPLPGPSKPVFGFAYKYCARCSAAARVLRPMRLGGIGDRSYKGDQYFNRCIFAGVQCIFADSVSSPDVYSNLTRCPPSSQPPPSLHSHLHPVSPAQGNMSADDEGEEQRGQSRYSYYRHVDTGEDSDDAYEVDGSNRSTTTHRETSLRRHREWMETTPEPETSAQVSRRRTFQSGLDAYLTETYGPRGGKDTRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHH8</accession>
    <name>A0A0D1ZHH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016383970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHH8"/>
    <dbReference type="GeneID" id="27336737"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09654"/>
    <dbReference type="HOGENOM" id="CLU_044876_0_2_1"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="325" mass="35914" checksum="17FA650348E878E0" modified="2015-04-29" version="1">MVKLAIAGGSGQVAREIIDALLATRNHDITILTRNETHPNDDLPGIQRRVVDYSDQNSLVEALRGFHTLLSFIQPLSDPEGRVQKTLIDAAIAAGVKRFAPSEYGSAGTINMPWWSGKEKIREYLREVNTESKVLEYILFQPGLFLDYLAFPYKTSKHIDPLRSVFDIQSCRALMVEGHGDAVMTLTSAKDVAALVARAVDYQGQWPEVGGISGNRMSVAQIIATGEEIRGRPFTIEKVKSEDLEAGVLKTSWSLAKRHQSISEEQANGMATTVSIGILLSCSKGAWDVSNELNQLFPDHHFDDMQSFLTRVWDGKPEELVSSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJU6</accession>
    <name>A0A0D1ZJU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233298.1">
        <property type="nucleotide sequence ID" value="XM_016382595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZJU6"/>
    <dbReference type="GeneID" id="27335352"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08269"/>
    <dbReference type="HOGENOM" id="CLU_1571503_0_0_1"/>
    <dbReference type="OrthoDB" id="4154650at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="198" mass="22651" checksum="8B02AAD9CF7BFA0B" modified="2015-04-29" version="1">MPVEKEQQNLQLIFDARRKYKASPSTAESIFSVFKHDEDPYKCDVMVKLDGETKYLGRALLDTGSMYSMMSEKTAVRVEAWGLTTIDRSEATRTEGIKTAEGILEEAKIKVVGKLSLKFSGDGVHYYRHTFIVIPHEDRFEILLGAKVLHRWVTADRCANSSSQSPLAKYRLLAPLGRTWDRRSCRQMLRSTLDFIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZL43</accession>
    <name>A0A0D1ZL43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233718.1">
        <property type="nucleotide sequence ID" value="XM_016383015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZL43"/>
    <dbReference type="STRING" id="91928.A0A0D1ZL43"/>
    <dbReference type="GeneID" id="27335773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08690"/>
    <dbReference type="HOGENOM" id="CLU_074611_0_0_1"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF8">
        <property type="entry name" value="S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="116"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29676" checksum="BC7533688051717B" modified="2015-04-29" version="1">MSSSSATSQENGHYPKIKLYTNYGCGWCHRVQFVLKELGLAYEQVLVDLDNPRPEWFLKLNPRGLVPVLQYTASPTSPPLTLTESGAIVSFLTDLYPSHLLPTLSPHSPSAPPSADDIEKAHLRYRMVFFVDTYFSKIQPLFFKLVGADDATAKAKLVDDIVALLEKEIEPLLADAQPYFAGSKDATFVEAMTAPLMARMYDFTNDVIFPSALGERMTGPTMPNFARWLALSSSHPSVLATWDKEYFIPRIIERLPRAKAKYGPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZN03</accession>
    <name>A0A0D1ZN03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234433.1">
        <property type="nucleotide sequence ID" value="XM_016381331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZN03"/>
    <dbReference type="STRING" id="91928.A0A0D1ZN03"/>
    <dbReference type="GeneID" id="27334081"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06998"/>
    <dbReference type="HOGENOM" id="CLU_007860_1_0_1"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="62"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="770" mass="85516" checksum="8600E3E6AF708E1E" modified="2015-04-29" version="1">MDGAKEKPVKAPRRTKKKRGNEKLIPWLYDLVLWVMSVLIELFFREVHPRGAWKVPRTGPVILVAAPHANQFVDSLILMRILKTEARRRISYLIAEKSTHRKFIGTLSKAIGAIPVARALDNVKPAQGKIFLPDPENDPTLVKGIGTDFKNGRFEIGGLIVLPKVRGQTPSTDIAEIISSTELRLKKPFKTQEALESITKPASDGDSTPGCSFKVAPFVDQTKVYNAVFQELDAGGCIGIFPEGGSHDRPDLLPLKAGVAIMALGAEANHPGCGVKIIPIGMNYFHAHKFRSRAVIEFGHPIEVHPDQVAAYKSGDRRNAVGSLLETVYQGLLSVTQACPDYDTLMLVQAARRLYNPWGKKLPLPLVVELNRRLVKGYTKYQDDPRVVAVKKDVLNYNRQLRALGIRDHQVEWGNAAKRPWWLVFGTLIYRLGELFLLGIGTLPGLAMFWPVFVTTKVISVKKSREALAASTVKLQGRDVITTWKLLVAMAFAPALYAYYTIIVSLWLVYNRRDGYYTYRVPWWMVARTYVPDFVPIWLFAVSFLVLCISITFAALRIGEIGMDVVKSLPPLFIALNPRSSSRIARLRETRAALSVKVTELINTLGPEVFPDFDAERIVADPFREGAYQSSYKKMPEEPRLLDGGEPMAPTPGAFEATSESPVQRSFSSMLPSNESFGNIGGFGFFASRPTTPKSRSRSSSAGGALTSASMPLKALSTLNTTESFDEVSKRIRGAMRERGRKRESEGMDTGTESSWDMASEGDEEPKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZNI2</accession>
    <name>A0A0D1ZNI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234613.1">
        <property type="nucleotide sequence ID" value="XM_016381511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZNI2"/>
    <dbReference type="GeneID" id="27334262"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07179"/>
    <dbReference type="HOGENOM" id="CLU_1023196_0_0_1"/>
    <dbReference type="OrthoDB" id="5424338at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="272" mass="31166" checksum="DC63F92A35858927" modified="2015-04-29" version="1">MAPRKFGEFNGLEAGMKWFQQDGGRVTITREFWSGPRVLPDGCRLALALTELCSERGIGRVYVLARHPDPANIHRERERSRAAMRFQEVPELCYVPELWTAEEIEAWPNLKPIEQLSRLCARNWVVDRLTVLPIDVQLVEKAPKTLFLQAGTTATVTLYIHTQLYAGLTKDMRKMCNKEPEFTSNFDRDRVTGCHYMIKNNSLQSLKSFRVDTGEALLDQFEKWHREAFENGNELVMTFETLMNFMIDAGLSAVSDGHAYGEQGEVEEEEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQY5</accession>
    <name>A0A0D1ZQY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235438.1">
        <property type="nucleotide sequence ID" value="XM_016379611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZQY5"/>
    <dbReference type="GeneID" id="27332350"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05267"/>
    <dbReference type="HOGENOM" id="CLU_068979_4_0_1"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="213" mass="22910" checksum="49D11A756F325F15" modified="2015-04-29" version="1">MVYGSRAILSSTDAASPLSVTPPETALLLLDYQNIVVSRLADAAPIVLNTARQMRDWALSKGMLVYHCVFDARPGSRPFPRSKMALNWRMIEDKFASLPELGYEADVLAPIDPGQERMVVRPPGIVSALESAGLLEELAQRGVKSLMLCGLTTSGCVLSTARQAADRGFIVTVVEDACFDPVPGLHGMLSAHVLPATAHVVISAELKDAWKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZTE6</accession>
    <name>A0A0D1ZTE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236243.1">
        <property type="nucleotide sequence ID" value="XM_016380416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZTE6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZTE6"/>
    <dbReference type="GeneID" id="27333161"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06078"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="62460" checksum="10DE11F823EA3136" modified="2015-04-29" version="1">MGVLQTLNANGGAILPLTTVDILKYSLIGAVAIPILWVLVDYVRVLRLRRKMPPGPLPLPLFGNYFTIEKYKPWAQFERWSKEYNDPMITIWQGHRPTIMCNDIWSISDLLDKKASIYSSRPRMIAMGDMINATTSNQVNLEYGDRWRLHRRLMHTAVGSQAVRPFRDVQANESKILVRDLLERPDDFVMAIERYSTSVVSIIGWGRRIDKINDYVGQLALQVMEGVDFIIPGLYIVESIPFLANLPRMLNWVYPWPKQMLNLSKHMQRYFAALSKEGAQMREDNFAKRLYKEQAQSGLSVEEIASLTSNLIGGGVDTTSGTTLAFILAMCAFPDVQKKAHDELDKVVGKERVPNWNDESSLPYVKAILSETLRWRTVTILGGIPHAPIQDDVYRGYFIPKGTPITGNVWAIHRNPREYPDPDSFRPERFVGGLERPYPNKQGHNAFGWGRRQCSGQPLAEQGLFMTIATLLWAFDMKPGLDENGNEVKLDTSLDGFTKSENMRPEPFKARFVPRSKGIEQIIRAEAARARKELTVFDGETRLTMENVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWX3</accession>
    <name>A0A0D1ZWX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small-subunit processome Utp21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237413.1">
        <property type="nucleotide sequence ID" value="XM_016378736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWX3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZWX3"/>
    <dbReference type="GeneID" id="27331471"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04388"/>
    <dbReference type="HOGENOM" id="CLU_002774_1_0_1"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="5">
        <location>
            <begin position="75"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="607"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="4">
        <location>
            <begin position="822"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1030" mass="111663" checksum="D704355E6F4F3AE1" modified="2015-04-29" version="1">MPSNSQRPSDSAVKVSRALSTSRHERVLDSFLHFEYALAAFSEDLLLTARKTLGLVSPTSVPFTSVPLGKTTFQITTSVGYALQTYDLQRGLNLVFLSRPQCPSQITSTCAYRDRVFAAWGGSHPASPRGVWVVKRGQVVGELEVDNTYTQEIERILVFGSWIVGCGKQAIEVWKSDTYEHYTTILPSTPAAASNSKEVFSGQICTLPTILNKVFVGRKDGYIEVYNVSTGRLVHTILAPSANCGSVTALSPALALCLLAVAYADGSLIIFDVESDEKVLELHQKDTKKPITSISFRSDGMGAGDDGRKSGSMATSSIGSGDITLWDLNRGGKIVGVLRGAHETSSLGQATGVNKVEFLPGQPVLISSGLDNSLRSWVFDENPFSPTPRLLHSRSGHSAPVTRLRFLPTASDGSDAAGKWLLSAGSDRSLWGFSLRRDGQSTELSQGAVKHKARKTGLLTDDGPGVEQFKASPIIDMACSLNRDGGMGAVGGQVWANAKTSNAEVTSSTGWESVVTAHLNDRFARTWSWGRKKAGRWAFETGDHKPVTSVTITTCGTFAVIGSAGGSLDMYNLQSGVHRQRYPPRLTPSQVKLLQQQAQSEQILTIPQGHRDAVTGIVVDSLNRTMVSTSLDGSVIFWDFSTGRLLERRADAQAVPTAIRYNPSSGLLALSCDDLCIRIIDIESRKIVRELWGCVGQIYDYCFSHDGRWVVSCSMDSIIRVFDLATGHLIDAFRTATCTSIAFSSTGEFLATTHAGSAGINIWTNKALFTHVSTRQVDEATGVIDLTETAAFQAASQLAIAEAEADADDEIDGIDDESSTVDQLDRSLLTLSIVPQSRWQTLLNLDSIRERNKPIQAPEKPKAAPFFLGSALTNGTGADTSLSTAAAEVEETERSRISRLALASSSQPSHSKISSLLTSFSLERDSRELCDYLTTLPPSAADLEIRSLTLSEMPLFVGALTAQLESRRSFELVNTWMSVFLKVHGDFVADVPGLNDAVREWRSVMQVEEERLSKLVGYTRGIVEFLRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZX62</accession>
    <name>A0A0D1ZX62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237498.1">
        <property type="nucleotide sequence ID" value="XM_016378821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZX62"/>
    <dbReference type="STRING" id="91928.A0A0D1ZX62"/>
    <dbReference type="GeneID" id="27331556"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04473"/>
    <dbReference type="HOGENOM" id="CLU_056802_1_0_1"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237953" description="CREG-like beta-barrel domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="67"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="262" mass="29153" checksum="D000794427459777" modified="2015-04-29" version="1">MHISITIVSVVLLLTSHGACAPVEAPEQLQLPRLQLQSEINNRVDVDSFSPAYDDEDEAPLRIPSRYESTVLGRRLLGLSKTGVLTTVFPENTTSSRVPADVANTPIGLPDYIASCEEPSGNPTLLALTVSTSTKNAVAGSNVSLSLSWWDEYVHLTHTQPWSAANLPRLSMIGYLEEMSAEEVESQGIPSCFTKIHGDSVMWLPGRKWAAHKGLWMRMVVREVYWIGGFGDRNYIGWFDRDEWRGVKEEEWANVRLPGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZYD3</accession>
    <name>A0A0D1ZYD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3 10">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04852</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3 10"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237873.1">
        <property type="nucleotide sequence ID" value="XM_016379196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZYD3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZYD3"/>
    <dbReference type="GeneID" id="27331935"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04852"/>
    <dbReference type="HOGENOM" id="CLU_033446_1_1_1"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043647">
        <property type="term" value="P:inositol phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="363" mass="39090" checksum="2AA736A68979C431" modified="2015-04-29" version="1">MTAPYQKELDLGLLAVQRAALLTKTVLASVDKGAQTKEDNSPVTVADLGAQALLISAIHHNFPNDEFVGEESSETLRHDKHLCDRVWDLVRTTCLACQDTQHLLGTISSKDDMLDAIDRGCGRGGRSGRIWMLDPIDGTKAFMTGGQYVVALALIEDGEQRVGTLGCPNLHLERFGGEVSDASAATEGEGVVISAVRGQGAYVRPLSLSRPGLLLSLDSEVRRISKPPRRSGRPIQFVESTESRSSDLDAHRGVAEKLGSNWPGTEVFAIQMRYVAMAAGHCDVMVRIPSDNEHHEMAWDHAGGVLVLQEAGGKVADLDGSPIDFGAGRQLQHNHGIVAATNDVHAQALKTAQEILRDRSKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZ55</accession>
    <name>A0A0D1ZZ55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238158.1">
        <property type="nucleotide sequence ID" value="XM_016379481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZ55"/>
    <dbReference type="GeneID" id="27332220"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05137"/>
    <dbReference type="HOGENOM" id="CLU_000960_25_1_1"/>
    <dbReference type="OrthoDB" id="2587356at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="597" mass="63949" checksum="33060419B1A2A8E2" modified="2015-04-29" version="1">MNSTQEPNTTEQQKSAAKSGTTAADERLFELADAGEMDVLLGWRTWLVVFISAFLTLFMQIFTTVAAPSVIAFIVQDIGDQAMSAWVLQTPLLIQAVLNPIIGRLSDVLDRKMLVTLTPIVAFAGSVMSARAHDMNLLIAGGVLYGVTLATIGVVGTIPAEILPLKYRTLASGIGFVGGASGGLVAGLAAGAFCRTPGGWRNMFWVQAALQLLVSASFFIFYSPPKVDREIPRMRITEIIWACDPVGSCLYIGGATCCLMALNWASGLYSWSNPHVVAPLTIGIVCLLLCGVYEWKGRADGLLAHVFFERGLNFPLALFITMVEGWIYYSAVNTIMNQMTFYLGWETDSLIIGVRQLVYSGPTIIASIVIIWYSTRYKDLKWPLVICFTLFLATAGAFAAMKRDWNYVSLGISAIAGVGQAGPLILLIAVVQYAAPHAFLSTATGLAFSIRAIGGAFGSAVLYTIVFGHVKSHYGTAVAKASIAAGLSPEEVPILLCVMAGGNGPPTEALLARVLSQALPSATLPIIRASRTAGQVVYARGFQLAWASTVPMIVVSLVCCALLQGVERLMTDKVESPLEKTQRDLEVKITTSAEAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZ78</accession>
    <name>A0A0D1ZZ78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238178.1">
        <property type="nucleotide sequence ID" value="XM_016379501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZ78"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZ78"/>
    <dbReference type="GeneID" id="27332240"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05157"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="493" mass="53050" checksum="D8D37A145194C106" modified="2015-04-29" version="1">MTVSPQSGISFPNGMETRLYINNEFVPSRSGQKFDVINPATEEVTASVFEADGADVDAAVQAAKAAFPSWSALGGFQRASYFYKLANLVESCNFDLAKLEAVSMGKPVGKYTEGTNMARFIRYVAGKAADVKGESSLQTAGFVNLTFRQPYGVCAAIIPWNAPVTEFFFKVTPAVLAGNTIVLKSSEKAPLTSLLLARLCQEAQIPAGVINVLSGMGPTCGAAMASHMDIRKISFTGSARTGRAIKQAALESNLKHVALELGGKNPLIIFDDADLSKAANAAASSILYNSGQVCIASTRVYVHASILERFCDLFTSSLVKQAANPIKGNDPLSPFTVRGPQADKAQFTSIMKYITDSRKAGYKILTGGDREGERGFYIQPTIILNPEESSAVMREEIFGPVVCVRSFQTEEEVISLANETEYGLYASTFTRDLSRAMRMARSLEAGIVGLNCTSPMMTLDMPFGGVKQSGDGRENGQHALDDWTELKTVYIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4B5</accession>
    <name>A0A0D2A4B5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FMR1-interacting protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239908.1">
        <property type="nucleotide sequence ID" value="XM_016374632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4B5"/>
    <dbReference type="STRING" id="91928.A0A0D2A4B5"/>
    <dbReference type="GeneID" id="27327349"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00266"/>
    <dbReference type="HOGENOM" id="CLU_030447_0_0_1"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMR1-interacting protein 1 conserved" evidence="2">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="459" mass="49545" checksum="13683A73FA4D7FF2" modified="2015-04-29" version="1">MSGQPFTFPPPPPPPPKRATEPVNRPNNNFSSNRGSSRGFGRGGRGGYPNAPYHANNRQQHGSHRDGWNGPQKRDHNTAFRSTNQPNRRVSAASPAVPSFNASIEHLLPRKPPQATPQPPSQKVADVPKKQNLLGLTPTRVDADSEPEDDEGEEARLAGQSKVSAGLEIEYGGRNITLSTPAEIAAWIAERKKRYPTQAKIEVAKKEADERKRRWQEEKAAKMQAAREARQKALEARRRREPPKSQKSESQVEGTGRADSAAQAKTKAERLRAKALKARERLAKAEEALRLAEEQPGSGTLTANENQTEPIADDTSSSALTDSDATSSSGSDSDSDSGSDSESGSDSDADSAPEVLSTKRAALEHEFSNAPSKPPAPSSQAAGPEDASARGGCNGNGNSKRNKNQRVDASTSSRTAGRRKGLWQVMVEQEQEEERKMLLQAIVTLGEHGVLDEPEPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4Y6</accession>
    <name>A0A0D2A4Y6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_00457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240098.1">
        <property type="nucleotide sequence ID" value="XM_016374822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4Y6"/>
    <dbReference type="STRING" id="91928.A0A0D2A4Y6"/>
    <dbReference type="GeneID" id="27327540"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00457"/>
    <dbReference type="HOGENOM" id="CLU_038839_0_0_1"/>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF32">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G04120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="190"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW19882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="339" mass="37058" checksum="8DD4FB869951881C" modified="2015-04-29" version="1">MTTTVHITCLCGKNAETLQLDAHLPVSVSPCSCDECRRSTGMLYFSGLPIPSRPGVVDALTEYKSSEKLSRYFCQTCGSHMVLHVVKDDAWSVCSGVVERVVGLEQVSRLSLEKIVQHEFVGDTRDGGLAACLANFHGRSVPLFDQGPGGGELERPLVAHFDWPDSGNSSEAAITASPTYPPLSNQTNEIDAACHCGGVKFRITRPNALSSQCSSPFPDLSCRLGAGSPIQCWAFVPKANIVQANKEPLSYEMGTLKQIESSKDCFREFCRVCGATVFWHCRERPDLVDVSVGLLRAGEGSRAESLLEWWTERVSFREDALDKGLIEALEKGLRDIGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A723</accession>
    <name>A0A0D2A723_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240768.1">
        <property type="nucleotide sequence ID" value="XM_016375492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A723"/>
    <dbReference type="GeneID" id="27328210"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01127"/>
    <dbReference type="HOGENOM" id="CLU_472533_0_0_1"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="67543" checksum="A6F6B60D50274275" modified="2015-04-29" version="1">MANSNDSAANSYTFVDYQNTPNHSASHRRAVKSHISSKYRTSVRQQKQPRYALPQRSPVGAKEVAGEGREGSEVGLVRRRPTRPSTHSPATPQTLPFSQTPSPSEMNFNGIRTDPFDALPGKHTPCVRKALDYYTQVLSPLHEPLLMAMNTVNPMMTWVFPLVLKHESAFHGAVALSQAYLEKRQNPLLPFSQEVDFHRRMAVSILHDHLLNHEGPPDDATLMTVLALAALDVLDGSDNIAHRNGLALVVAQKGGLDRLGCRGLVKAYLIQFDYFWMLETGGKSIFPLAKRKKNRIYPQHPFDPDMLALIGTLPEGFRALAYQGTLGVDVVDILSRVNRFARAKANNLHLPLINDPIPDGQDYQDIFDTCSCLHASASTEHSLEKNICLAIILFCFDIHSPAGVSAKITPYRGARQELTRSLKFTPWDTPSERACLIWMWMIVIASWKLDHDLSHESLWLCQTFFEKFPEARSWSAMSRAMQQFLWYEPLKHAWGTSWREALSDHQRMQQNPRLMEAGEEIQRSPLSSSGTKHSTRESTPASASSAGFGEDWTRPRSLPTRTRQTSQARSQDAAEDGTPGPPRTNVPLPPMFTLDTYLGEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATQ3</accession>
    <name>A0A0D2ATQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230106.1">
        <property type="nucleotide sequence ID" value="XM_016386298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATQ3"/>
    <dbReference type="STRING" id="91928.A0A0D2ATQ3"/>
    <dbReference type="GeneID" id="27339074"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11991"/>
    <dbReference type="HOGENOM" id="CLU_006240_1_0_1"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042511">
        <property type="entry name" value="Sld3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="3">
        <location>
            <begin position="281"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="654"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW09890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="959" mass="106635" checksum="CC2263DC2120C252" modified="2015-04-29" version="1">MQSPSTSERSALVTVASSTLNTISNSLPNNKKRKVSDLYSKEAHTETLTATVLPARSQSWDLERVTLLARAYLPLSWLATSQPATVIVFETPTSFVQKWNQGALITKRKSNGVLYAIERGGLDHFIALALQSWVSEEHCKDAALGNVAETRLENLLNKDDGAQQTHRRSASGSSFTALPTPKSPRRPTNRRGALARMSILTQKDTKSQESVFQTSSSPTLIQQPVLAHSSSGTMLPITPTAQTETANPFEQPEVVAEEVSISHQIQPVPPALAVENPCASERLRAQYLEHLYTSKTSLAFYVKGPLSRARAHVRSSQNPSTLLSELMEFYAQSILPAKKLDTKYKDSLPNILAELPLESTESSKKKSRKKKQKLGKDCLWPEEDNYVGRWWRTRDLRSISSSGDRQSEIRRELADLRMRETKMQLLLVLEFMLLEMAASKLSEKPIPTDPDVKVESVEDDVPSVLAKTPQKSSKKKRDATNELDTIIERLCIWHSVSLTDATATENAQKDHTSQSGDSLREFCKDVLWPFYSAKLPEQMKAVSRKLSGLESSPNRPPQMSKGSHNITAPVPLLKSRPGEPLVKRTLQRVLSEDHLSRHASPPTLSRASTGPIKPSIPTLKREPSERPMSRGGMLSKSVSFSNREIDLVADSKIRDAKRRKLDKLAQQKQELEAAIDALKRPSRSAVAAAFMDEVEKRQQEKTVQISATPRARRIRDPGEFSEPELPPMPRQVRGEEASVVIPSSTRKPLAAPPRVPSSNSVVRSSGTKRAVLSAIHETPSRAKERKEPHPSALSRIYEDFFDEDEEGERDAATAGPIKSPPRPRPSVNPYDGTSETAMEPRSDLGVSSSSQMSSSRKDELCMTRSRRPVLFTPVKKSDVRVEHAFRDAPEIPQRAGLMMNRVMGGHGRALDFGFNGREEHATNSPSHPRDVEKNVTVQVADGENEDIYDKLGWNDDFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATY2</accession>
    <name>A0A0D2ATY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230151.1">
        <property type="nucleotide sequence ID" value="XM_016386019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATY2"/>
    <dbReference type="GeneID" id="27338794"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11711"/>
    <dbReference type="HOGENOM" id="CLU_1927612_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="131" mass="13999" checksum="79C75E4F49D6407A" modified="2015-04-29" version="1">MTELVCEPEVDDDPDEAEVADVDSVDVLMAEDVPELDTVAVVVLRADEVEIAELAVLILDDEATEVVPEADETVADVDDGPPEEDEEDRVGTCSGINEGRHEVPCAVQAETTCSSQLSQSTDKEPSVEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AU87</accession>
    <name>A0A0D2AU87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230216.1">
        <property type="nucleotide sequence ID" value="XM_016386084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AU87"/>
    <dbReference type="STRING" id="91928.A0A0D2AU87"/>
    <dbReference type="GeneID" id="27338859"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11776"/>
    <dbReference type="HOGENOM" id="CLU_002540_2_1_1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249150" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="450"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="826" mass="89600" checksum="D468644CFFD51593" modified="2015-04-29" version="1">MWPSHACFFWLYVALLICCANGQSTYWLANKPNVGKVAFQTDPNYPVFRNVKDYGARGDGIQDDTDAINNAIAAPGSLSTITQRLNGRCGGGNSTVGSFCESATVTPALVYFPPGTYKVSKPLIMYYMTQMVGDAVTPPTIKVAANFTKIIGLAVMDADIYIPSGSGGEWHANQNNFWRQVRNFIIDMTTAPLDTAGIHWQVAQATSLQNIVINMAAKDVVNNAQQGIYMENGSGGFFSDITVTGGALGMYLGNQQFTTRKLSFNGCSTAIKMNFDWLWLFTQVTITNSNVGIDMTNGGFSNQATGSVVVIDSVISATQGILTPYAPGYSSPQAAGTLVLERVDFTGSPAAISAAGGTQARTVLAGGQFIELFAQGNAWTTAGQGLNGQTFNGTSCTYANSSQTAYTAQETTIQRQLAPIPRPSNLVDSNGQYIYRVKPQYETLQWSSFLSAKANGLAGDGQTDDTAAMQNLFNLAASTNKVVYFDKGAYIVTSTVKVPPNLKMTGEMLPIIMATGPFWGDQMNPKPVLKVGNPGDVGTVEISDLIFETRGPCPGAIIVEWNIKAQGPALAGMWDAHWRIGGSAGTNLQSDKCIKTPSQPITSGSSVLTDCIGAFLLLHVTPQADGYFENTWGWVADHELDLGTREQIYIFNKAGFLFESAEGPVWLYGTASEHSVMYDYQFSNTKNVFMGHIQHETAYYQGNPDALHAYFTPQSSWNDPTYADCTQPNCARTWGVRILNSSSIFMYGGGLYNFFENWNTQACLGTESCQERMVDIQNSTDVYLWALSTKGSQFMISYEGTDVVPYSVNRANFCETIALFELAESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXC2</accession>
    <name>A0A0D2AXC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231266.1">
        <property type="nucleotide sequence ID" value="XM_016384664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXC2"/>
    <dbReference type="STRING" id="91928.A0A0D2AXC2"/>
    <dbReference type="GeneID" id="27337432"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10349"/>
    <dbReference type="HOGENOM" id="CLU_013390_2_0_1"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000504">
        <property type="entry name" value="C2H2 transcription factor swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001649">
        <property type="entry name" value="C2H2 transcription factor Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="710" mass="78609" checksum="F2C0F23E827D687B" modified="2015-04-29" version="1">MMSNPPSSLHHGQAMHRRQHSTPVAASEAMKVNTSMPPQRQTLHKRGQSFDQQRSPIRRQQHHGNTRQKIARPGQHLQLNLDIPISPDCGIYSGVSGSMPETLENMPMNAFVHQNPQCMEFPHSQQFFSDMNMSMRSGMPSMSVMDENSPQYLFDAQAHNLHSQRTRNLSFDARRQSQPELRVQTQLRPHTPSHQIQTAQFPLTPPFSQHTSGAQYSRSLQASPSLQSPYPLPMTRDRSLQGIIEHEEFKADFMNTPTAANFEIAELPTPAARRQLASPQMLPQGEPRKAVGSSPPAMPSDDNMPKLGERPTPVLTTGAVPAGSASPGRPALSPRRMSISDLNLEPGISASIEETNITLDDIAQFIEGPDPADNKWVCTYPQCDKRFGRKENIKSHVQTHLGDRQFRCDHCGKCFVRGHDLKRHAKIHTGNKPYPCACGNSFARHDALTRHRQRGMCIGAFEGTVKKIVKRGRPRKHRPEMDERVDKAQRTRTKNAAVHGSEFSNDPYPSSSSSYSASSYGSPPTEDMDNLSIRATPPFDNGMQMFGSISSNNNNRHVVGIEPMLTFPPDSFSFTPPASPGYSTGNKPSPTYRELSPADFIEHAAEASQMLPDLPSMDPSLSVMNGVNNNHGYSAQSLPSLSHSSSSPAADVVAFDFSDHLPPDSSSAMVMSSSQMPMKLDNDRNDFDAFLDYGGMEMNMDPGVQDFFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXP5</accession>
    <name>A0A0D2AXP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_10763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231679.1">
        <property type="nucleotide sequence ID" value="XM_016385077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXP5"/>
    <dbReference type="STRING" id="91928.A0A0D2AXP5"/>
    <dbReference type="GeneID" id="27337846"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10763"/>
    <dbReference type="HOGENOM" id="CLU_072692_0_0_1"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34816" checksum="49A36378CC266A84" modified="2015-04-29" version="1">MNSLRLVSRALPKASLRRSVVRYSSSVSRLALRRPVWQTAAKASYPAFSTSAFRREAAGDFDVELSEKLNSEQQLELENSGEGALSEINDFLKNHDYWKVQDKPGTHEVFFTREFGNEKIKVALTVADIDNIADEDEYGGMDEDAALDDEVDYGSNKATINQSGVRGGKVDVMPEDSIAPADRDAEDTGLPDETPAYPINLTITITKPSKRAIEIRAVAQEGTIELDSISIFPKESLLEAQTPKDAQEARSLYAGPTVGNLDPDLQAMLEKYLEERGIDVDFANFLPKYIDYKEQREYVQWLDDMKTFVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZX8</accession>
    <name>A0A0D2AZX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232191.1">
        <property type="nucleotide sequence ID" value="XM_016383568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZX8"/>
    <dbReference type="STRING" id="91928.A0A0D2AZX8"/>
    <dbReference type="GeneID" id="27336332"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09249"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_1_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000030">
        <property type="entry name" value="Thymine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="193"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="350" mass="39453" checksum="30CEEE09A0167EB9" modified="2015-04-29" version="1">MGSLGNTVQKGVEQDDLVMPLIDFGAFLNGDPSIKRTVAEQIVEAFKTSGFLYLEHHGIPQDDISRAFDESARFFQRPQSQKDELQWTTPDSNRGYVAWGREKVTQSADPEEIARLRASNPDLKESIEIGREGVPGFPNQWPSRFGDDEGKRFTDDMQSFFLRLKDLHVQVMRAIALGMGYDEAFFDGYTDAGDNTLRLLHYPSVKKSLWKQNPNQVRAGEHSDYGSITLLFQDDIGGLEVKSPRGTWVRAKPIPGSIVVNAGDLLSRWSNDTIKSTNHRVIQPPPKETAQDDDDDENAMVPARYSIAYFCNPNFDRYIEALPGTWEKTGKKYEGINSGDYLVMRLAATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B041</accession>
    <name>A0A0D2B041_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_09314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232256.1">
        <property type="nucleotide sequence ID" value="XM_016383633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B041"/>
    <dbReference type="STRING" id="91928.A0A0D2B041"/>
    <dbReference type="GeneID" id="27336397"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09314"/>
    <dbReference type="HOGENOM" id="CLU_011811_1_0_1"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000512">
        <property type="entry name" value="RING finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="191"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="526"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="580"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="701" mass="78141" checksum="E15C6A910863629F" modified="2015-04-29" version="1">MSSSATSSPASSKLPFPSNSSNYSQAPSSAGVDLSSKRSNSSGSFGAGSSTRHTSQARANQALRKQHKGQQRKPRLLLDEDAIAETAAMRSINSRKGQTSITHLMNFSLPPRPQNHYQHHFNHRHPRRNPTWGLGSGYHAVDKARYVHANYRFIVRPDREYHAQTSDADVYVSWDAVLQVLASAETQAASCPICLSTPVAPRMAKCGHIFCLPCLIRFMHATDEANPVPEKRARWKKCPICEDSIYISEARPVRWMAGQDASMLREGGDVLLKLLKREPGKTLALPSETASGYGRADDIPWFHVAAVMEYARFMKGGEEYMRSQYDQEIVALDAQEREDELMFGDENTWTRKAVLAIEDAQQKLAGLGNPPPTSTTVKKDDEIPESWETADQPLPSALASAMRSLTVGESSSISTSPSNTLQPNTGTMRSQSHAFYFYHALPNFFLSPLDIRILKTAYGDFSTFPMTILPRVEHISTGHIVDDELRKRAKYMAHLPYGFEVSFLECDWTDIIPPSVLEQFQDDIVRRRKRHSEREAREERDRIRAEKEEDDKRWAPVRRQRRESSAPRSFSESDFRPLIDTNTHPSSSPGESGLATTPPWNTRTHSSFAALTTPGTSPDAPRTVWGTAAVMATSPPLTAAHEPTHDDGWLQGWEKDLLDEHDAVAMVEASLNDGSKAVGTTGKRAKKKKITLMSTNNRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0J9</accession>
    <name>A0A0D2B0J9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_09516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016383833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0J9"/>
    <dbReference type="GeneID" id="27336599"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09516"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="510" mass="56738" checksum="AB38EF7DAA3FA7DA" modified="2015-04-29" version="1">MDRSEAEKGRDVIEARSAAPSQDVGHGSLSEKYEVDTLHNDEAMKVLATYQGNPAWDTQEEKKVRIKIDRRLLPILAVTYGLQYYDKTMIGQAALFGLRTDLGLTTGNRYSMSSAIFYLGFVGGSYPAAQLAQRFPIERVAGGLVLLWGICFVLTAACFSWQTFYVQRFFLGFLEAGVSPIFMLVVGQFYKKNEQSFRMGVWYAASGFITLVSPLVNYGLGHIQGSLSPWRYMYIVGGLITVLWSVVIYFFMPPDPIRAKGFDERERYIAVARLRTNNSGVRNTHFKIQHVLELFLDEKFWLIFAQAYLSMIASGPVNTFMPIIISGFGFNTLNSLLLNIPAGAAGAILILGATYTSYKFRNMRTIAIFVAELFVIMASVLLWKLPRDSKGGLLFAVYMMTAYSAGWGVIMGLSIANSAGYTKRVVSSSAIHVGYCLGQFTAPLLFKPKDAPEYAPGFIAVLVTAAASAGLNLLYRFVCVWQNKRRDRAGILEAFDHAYEDDVTDKKVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B136</accession>
    <name>A0A0D2B136_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232834.1">
        <property type="nucleotide sequence ID" value="XM_016384211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B136"/>
    <dbReference type="STRING" id="91928.A0A0D2B136"/>
    <dbReference type="GeneID" id="27336979"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09896"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051638">
        <property type="entry name" value="CTBP_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029:SF7">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="130"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="313" mass="34838" checksum="9CFCF491B0FC0BB5" modified="2015-04-29" version="1">MATTTSIPTYTIIQADGLYPDDVVEQKILNEAPTHEYRVRYVQTDLWPPGTVDAKPWSAIEKALRDEVDGIMVLKMRFTAEDLALFPKLKVIVRMGVGYDRLDRVALAARGVTVCNVPDYGTAEIADHALALALSLRRGVLLHHDHQRGPQPSPWAYIESPLVERIQKSTFGILGLGRIGTAAALRAKAFGWNVLFYDPYKPNGTDKALDVERTKDIRELFRRSTTLSIHCPCTRETRGMVGYDLLSLLPRGAVFVNTARGEVVDLDAVERCLKEGIISGAGLDVLPEEPIPEPAHPLIQAYRNKEDWLTGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2D1</accession>
    <name>A0A0D2B2D1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233249.1">
        <property type="nucleotide sequence ID" value="XM_016382546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2D1"/>
    <dbReference type="GeneID" id="27335303"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08220"/>
    <dbReference type="HOGENOM" id="CLU_000960_25_3_1"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW13033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="570" mass="61543" checksum="3070921BE6D6E8CC" modified="2015-04-29" version="1">MSATNLGQEGKQPDLMHVEKGEKNLADDVDVHNEFAYKGDDSDGKAAWTFRHYVAAVSLGMLYAGSQANLYFVGGCLSFMEADLDAQKVGSWLPVSNTLAITAMAPFVGYLQDLLGRRYITLAGMLVIMVGIALTGSAHSFGQAVTGMALAGGGAGVCELTSLAGLSDIVSVRHRGFALALMTASLVPFTPYVMYSQLLATYVTWRWTQWIVLIWNGIVFVGLLTTYFPKSHPRMEGMTNREILARIDYVGAALSIVGLTIFLVALQSGGYTHAWTSAYVMAQLIIGIFLILAWIVWEWKFARYPMIPRELYQTQRVAPLAFLVAFIAGFDFYSLINFFPISFAALWDPDPVQIGLKGLGYGISTTVGAVFWNSMLSTKMPAKYILLISSIIMTTFTGALAATTPETPRMAVAFGTIASFGVGGILVPAATVAMIVVPDSLLATTAALSLSIRTVGGSIGFTIYYNIFVKKLTSQLPVNVAKYAMKAGLPASDVEEFVLTFLTAPAHITHAPGFSPQVLAGATMGSRWGYAEALKWVWITSIPFGALAIIACFFIPSIKKYQTNRIAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2D9</accession>
    <name>A0A0D2B2D9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233264.1">
        <property type="nucleotide sequence ID" value="XM_016382561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2D9"/>
    <dbReference type="STRING" id="91928.A0A0D2B2D9"/>
    <dbReference type="GeneID" id="27335318"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08235"/>
    <dbReference type="HOGENOM" id="CLU_007003_7_1_1"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF83">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="730" mass="81387" checksum="F83841EE36742C36" modified="2015-04-29" version="1">MSSLKLNAEKTRRVAIACSACQQKRVRCEGTEPSCRRCIENGITCEYQYRENKRKPPSKRFVESLQARIKVLESQLSLLGKDTYDLLLNDDGHIPGDEAEGMGETDESDDQSALSPMHDFVRELAHTYGSLTLDDNGQLRYFGPQSNFNLLHSYMDHRDRQSVHDVQDHGVPSRTWVTPEIQIPLELQEHLLDLYFCWQNPWLYLIEKEIFLRDFRSTDRTRYCTPVLLLAIFSVAARYSDRTEIRANPADPNTAGDEFAQATKTLLMIDCEKPTVTTVQAAALLALRWIAENNEPAGWLYTGMATRIAYNLGLNVDSDKWLKSGLITEEDAEVRKVAWYGCWTLDKLFCLHLGRSGTVPDRDVTCCKPSLSNSAEFEPWSSGQSGPGELFGAHARIASTAHYMTDHLSLVLHALDLIYAPNSKLSGAEVDALVSKTDLATNTFWSTLPSYLRLPSSSRTRALPHIYQLHIQYHVAQILLHRPFIAKNQAKPRSSKLVLDVDNIHLKLCRDSASEIVRLLRVYKHHYSLRLVPVGTVSHTFTAAIIHLMDATSGDPTIQKQGNAKLRFRISALQEMETAWFWSFRARRAIQILASAWLTKAPASPLSASTGRSQAKISAVTESAATAQPPYDISPHSDPGAGTMPVGFPATFSAFEQQSSNGSVPELSADDLNWIFNVDAATNGAFDGLGDWQSLNETDMWLSMAAQSTFATTNMETYPYSPNVEGSTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3U9</accession>
    <name>A0A0D2B3U9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferulic acid decarboxylase 1</fullName>
            <ecNumber evidence="1">4.1.1.102</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenacrylate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">FDC1</name>
        <name evidence="5" type="ORF">PV08_08543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-4-coumarate + H(+) = 4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33227"/>
            <dbReference type="ChEBI" id="CHEBI:1883"/>
            <dbReference type="ChEBI" id="CHEBI:12876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-cinnamate + H(+) = styrene + CO2</text>
            <dbReference type="Rhea" id="RHEA:46920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15669"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:27452"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29749"/>
            <dbReference type="ChEBI" id="CHEBI:42438"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>prenylated FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="1">Binds 1 prenylated FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. May form higher order oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family. UbiD-like/FDC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.102" evidence="1"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233571.1">
        <property type="nucleotide sequence ID" value="XM_016382868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3U9"/>
    <dbReference type="STRING" id="91928.A0A0D2B3U9"/>
    <dbReference type="GeneID" id="27335626"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08543"/>
    <dbReference type="HOGENOM" id="CLU_023348_0_0_1"/>
    <dbReference type="OrthoDB" id="4878259at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046281">
        <property type="term" value="P:cinnamic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033494">
        <property type="term" value="P:ferulate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1670.10">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01983">
        <property type="entry name" value="UbiD_FDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032903">
        <property type="entry name" value="FDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00148">
        <property type="entry name" value="UbiD family decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF17">
        <property type="entry name" value="FERULIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="3">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="2">
        <location>
            <begin position="121"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="4">
        <location>
            <begin position="327"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="172"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="511" mass="56501" checksum="BECFEA26988702B9" modified="2015-04-29" version="1">MSTETHSAASSLRTFLEECKAEGDVVEIDLEVDPYLESGAITRRAYESGSPMPLINNPKGKDGPDGLFRILGAPVGVRSNRVERYARFAKSIGLPSNASGHDIIQKLIASKRAGPIPSVHVRDAPLKEHKIFGDEIDLFKLPVPQNHERDGGRYFLTYGLHSVQTPDGKWVNWAITRCMVIGKRQLTGLVDVNQDIGAIWSMWKAQGKDTPWACALGVPPAAAVASGMPLPKFVNEPDYVGAITGSPMQVIKCETNDLVVPAQSEVVLEGTISATETAIEGPMGEYHGFLFPAKKAPEPVFTVNAITYRSNPIVPISVAGRAPDETHTVWALTICAEILDLLQQHGLPITQAWCPYESQAIWYVVQVDRARLVKMKTTPEKFCRQVGEIVFSSKPGRFVPKIFLVGDNIDPSDLHEVVWAEATKSQPQDSDFFFVGDYPTYKLVPYATYGLNISEPQAKVVRLCMLPAEFKTLDRPWIEASFRASYPEEIKSKVLKNWQAYGYQQQDSANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B570</accession>
    <name>A0A0D2B570_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7896 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234229.1">
        <property type="nucleotide sequence ID" value="XM_016381127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B570"/>
    <dbReference type="STRING" id="91928.A0A0D2B570"/>
    <dbReference type="GeneID" id="27333877"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06794"/>
    <dbReference type="HOGENOM" id="CLU_474090_0_0_1"/>
    <dbReference type="OrthoDB" id="5377599at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="2">
        <location>
            <begin position="458"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="645" mass="69250" checksum="140B76830F8244AF" modified="2015-04-29" version="1">MDSNVNAAIEMLKSCRQVFDAEHQHLSPGQREKGWSRHWSAIQAAMANSGTMPPLGSSVPQKRNASTMGVVGKEPASKRAGGPASLASSAPTAPCLERHSSTRSQSGPVSPIVQTTATTAPVVVPRHSSGQRRTSNAGSYPNRYQGTNLNYIQEVQDLSPTDFLASHGELSMTPPMNMERGESSNYLSTLTSPYFSAIESPAGYTPVTSTSDAGLTAASTILSEPMTRANTNDVLCEPFGMFRMDSMSMSQLPQTVDMLDMSQAHDVLDSQLFSFSSVVGTGHGYNNPACLSFVDDDSFPSSSLSSCSSSSSSSYEMKNSLSSGSNASSLSVSSRQSHHGRDRSQTQKQAAVHGQGGNAPGSCSLNEVSICVSRPIAPKMQRTVNASRSSFDDMPVPKIVAVKGEDGTVKHKAAIARATRQPPLRKTTFCQFCSDQPQGFHGDHELRRHIDRHHASLRRVWICKDASASGTFLSNCKACRNGKTYGANYNAAAHLRRAHFNPCKTRRGGRSKKSENRGGMGGGNYPSMEFLKNWMYEELEMNLNGRVVVQNIVPDTIFETATVNEMANATGGTVVVDDYAAAATAASAANNMQTPNMAMAMTPAPFDLMTEPLYFDNVLPPAPPAYAMPSNGYFGVPESQTPLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6S9</accession>
    <name>A0A0D2B6S9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016381499.1"/>
    </dbReference>
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    <dbReference type="STRING" id="91928.A0A0D2B6S9"/>
    <dbReference type="GeneID" id="27334250"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07167"/>
    <dbReference type="HOGENOM" id="CLU_041181_0_0_1"/>
    <dbReference type="OrthoDB" id="3232309at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="52354" checksum="4FB1E52A3F24BD0A" modified="2015-04-29" version="1">MFSSLPSWLDWYRKPSYRDPIIFSASIRADLENGLTSRPGSISSQSDSAIPSNLTLDHVLNNDTCSPLSLYDFYMYLKHIERSPENLEFYIWFKDYEARYNESSHTNSPTQETPLLFSSKDEKSSSAGGGTYCSLGFGAPGDATELSTPTTTTTTTIAATQLPDPAFQTYIEDLVVSQGSRRCRPFWDRSNNNNNTNPNSSDKTLVHAQAHTHGGGHAADLATKTATTMSAYPYTRREEVSHVVARYLTEDSPRELNVPPSMRAQVLSAMARGDLSPGPLRPVAEHVYYLLRNCSHRNFIRLGVKNGTFETLCMVTVVGVLFTALGLLTMLLVAFASPSVRRSSRWRGLASAPFWVVGFSFLFAGWRGSCFLLLLFSRRQELPWERLSDDGSTRTRRSSSSNNNNTATTWGRGLVRFAKKMMIFERKIRVKDRGLRKLQRKIVVQSVVGAVLATAILEVVFLVLPIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B718</accession>
    <name>A0A0D2B718_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein ARB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234949.1">
        <property type="nucleotide sequence ID" value="XM_016381847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B718"/>
    <dbReference type="STRING" id="91928.A0A0D2B718"/>
    <dbReference type="GeneID" id="27334600"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07517"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="103"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="414"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="635" mass="70349" checksum="63C78BE84296A172" modified="2015-04-29" version="1">MPVSASKAARMAKKAEKDGKKTAASKLSSKAGSKNASAAGSKASSVNGDDGSPMLDEDELDAPATSAQQMDKVKQLTEQMDKHGISDRVTTGVLASLESSRDVKITSASLVFHGKVLIQDSTLEVNFGRRYGLLGENGCGKSTLLKAIDKREFPFPEHVDIYLLNEGAPATDMGALEWVVKEAEKEVKRLDDLAEEILEKEGPESPTLMEIYERSESMDPNTFETRASLILTGLGFNKKTIHKKTKDMSGGWRMRVALGRALFVKPSLLLLDDPTAHLDLEACVWLEEYLKKWEKTLILVSHSMDFLNGVCTNMIDMRQKTLMYYGGNYDSYIKTRSENETNQQKAYLKQQEEIAHIKKFIASAGTYANLVRQAKSRQKILDKMEADGFIQPVAQDRVFSFRFADVEKLPPPVLSFDDVTFSYSGKPEDNLYEHLDLGVDMDSRTALVGPNGVGKSTLLRIMTGKLSPTGGSVSRHTHLKLGLYSQHSADQLDLTKSALDFVRDKYSSVSQDYQYWRQQLGRYGLSGEAQTALMGTLSEGQRSRVVFALLAIEGPNMLLLDEPTNGLDIPTIDSLADAINAFSGGVVVVSHDFRLLDKIAKDIMVCENKTVRRWDGSIGEYKNYLRKKMVSMGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7B6</accession>
    <name>A0A0D2B7B6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07608</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235039.1">
        <property type="nucleotide sequence ID" value="XM_016381937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7B6"/>
    <dbReference type="STRING" id="91928.A0A0D2B7B6"/>
    <dbReference type="GeneID" id="27334691"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07608"/>
    <dbReference type="HOGENOM" id="CLU_027089_1_0_1"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF24">
        <property type="entry name" value="FE(2+) TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="46590" checksum="1ABA1035269D4B98" modified="2015-04-29" version="1">MSKPQCGGGAAELSEYDLPLHVGAVFMVFAFSIAGAGLPVMGKRVSWARLPPRVIFFCKHFGTGVLIATAFVHLVPTAFQSLGDPCLPSLLTDDYPAMPGVIMMFALFALFTIEMYLKAKTGGHSHGGPMGNATSAPGPHRHGHAHVHRPGLAEQGARPGVGTPQTLPAYGVHSQDESEVDGFEKPHAYTHSYEISAVAREEMEQYNNLTDMPTWFQVFYAQYVRQREELKDMILAVTPRSFYPAEKSVFDDSSSVGVPDTDSEASVDAMTLKTMNLNISLLEGGILFHSIFVGMTVSITTDGFVILLVAILFHQFFEGLGLGSRIAAVPYPKQSIRPWVLVCAFGTTCPIGQAIGLLTRNSYDPSSAFALILVGAFNAFSSGLLIYAALVDLLAEDFLSEEASLIMTKKDKIQAFCFVLTGAAGMSVVGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7I3</accession>
    <name>A0A0D2B7I3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234856.1">
        <property type="nucleotide sequence ID" value="XM_016381754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7I3"/>
    <dbReference type="GeneID" id="27334507"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07424"/>
    <dbReference type="HOGENOM" id="CLU_1077822_0_0_1"/>
    <dbReference type="OrthoDB" id="3599804at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="258" mass="28284" checksum="7D1A05F580DC76BA" modified="2015-04-29" version="1">MPQKAAADLETGSPALKPKDFDYLFSRDDRHELFLEMVKVEVSNILSDYNLPSDGNANSTNPSSSCSGGNNNNNNNRTIFTTSDGQLLRRIAETQMKKALEDRIKEKQDVDKGIYTLLGRESIEAVRAINQAVVTIAALGAGFTFTVIFSGLAPPNKGSTEARVRLSVAVAWLLFVLAMSLASYATVLQAMREQMVTVTYRWRVAQGLILAGALCASAEAVRAYEAAVGVTAFVLIPTVTIGWMAWTNRFRVWKLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B871</accession>
    <name>A0A0D2B871_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235091.1">
        <property type="nucleotide sequence ID" value="XM_016381989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B871"/>
    <dbReference type="GeneID" id="27334743"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07660"/>
    <dbReference type="HOGENOM" id="CLU_131496_6_1_1"/>
    <dbReference type="OrthoDB" id="4641034at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050744">
        <property type="entry name" value="AI-2_Isomerase_LsrG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33336:SF15">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33336">
        <property type="entry name" value="QUINOL MONOOXYGENASE YGIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="113" mass="13176" checksum="08C80E284729C0AE" modified="2015-04-29" version="1">MTEAEKDWRETNWEIPEGEFAVFGKVYTDPEHTDKVEAIYRETTKRAHEEEGTLSYCLGRDPDDPSIIHFFERYTSKAAFEKHNDQQIIQDLVNSGWMKDVKAVFVKPIPPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9K7</accession>
    <name>A0A0D2B9K7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235541.1">
        <property type="nucleotide sequence ID" value="XM_016379714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9K7"/>
    <dbReference type="STRING" id="91928.A0A0D2B9K7"/>
    <dbReference type="GeneID" id="27332453"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05370"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_1"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="11"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="353" mass="37026" checksum="E74844B2541B19B1" modified="2015-04-29" version="1">MKAIYISEYVESPSDLRVTSIPGPTPRPDEDDVVTVTVTHSALSHVDLLYARGLHQNNHSGLVKPPFVLGLEFAGVVASARPTSAFKPGDKVWGASVGAFAEQIAVPASAVRRVPTGWTLADAAGLGPATAPVSYGALVRVARVTRGQTVLVHAAAGGLGVYAVQIALALGAKVVATVGSEEKAEVVRRGYGGSLGAAGAGAVLGVVRYDVDWWEKEVLKIVPAGVDVVYDTVGLVAKSIRCLKFGGSVVVAGFAGLNGKMETLSMNRVLLKGARLLGYRYGETGRRNPSETEQVWKGLDAMLESGRVKPVIYRTYHGLESVPRALDDLASRKVWGKAVVEIQPAPPSVGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9W2</accession>
    <name>A0A0D2B9W2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236004.1">
        <property type="nucleotide sequence ID" value="XM_016380177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9W2"/>
    <dbReference type="STRING" id="91928.A0A0D2B9W2"/>
    <dbReference type="GeneID" id="27332921"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05838"/>
    <dbReference type="HOGENOM" id="CLU_022884_0_0_1"/>
    <dbReference type="OrthoDB" id="1872003at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="91"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="461" mass="48864" checksum="DB04E7DD8E8746A1" modified="2015-04-29" version="1">MAYSQRCSLPTPLTPSMPLSGSITEQIESLPITPPEISEPFYDHNFVADSKTIKKALHVLATERLALSHLEDLYSNSAELQAFLLQAIRQIIQSETRHGKTIFTGVGKSGHIAKKLVATFVSLGIHAVFLHPIEALHGDLGVVRPNDTVIMVTFSGKTPELLSLIPHIDPSIPLIVMSGHLSEQSCVILRHPTRANSRNILIPTVIHESETASFGVSAPTTSTTITLAIGDSLALAVADDLHSAAGLQTPAIFAANHPGGAIGQQAGAHMSKPGHQHTSTATTAAAAAAAAAVAGGVGVGAGTSDPMAIAQLGPALDPEPRMSDIATIVSHIPIATPRPGYKDLMCFDVLLAAVRSPKGFVRTSPHHMIGPRRIQNLPSTEVGVADLTDAFGGVVIEKTDWISVLGSTTVDECRRWIHQMRNEGCGRGREFLRRGTLLGIVDGNNEVTGIVEIEEMMGEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAX9</accession>
    <name>A0A0D2BAX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235976.1">
        <property type="nucleotide sequence ID" value="XM_016380149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAX9"/>
    <dbReference type="STRING" id="91928.A0A0D2BAX9"/>
    <dbReference type="GeneID" id="27332893"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05810"/>
    <dbReference type="HOGENOM" id="CLU_013387_2_2_1"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014390">
        <property type="entry name" value="Acid_Pase_Asper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000900">
        <property type="entry name" value="Acid_Ptase_Asper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112390" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="79"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="273"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="531"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="605" mass="66712" checksum="85ED8EBC5AEC7C1E" modified="2015-04-29" version="1">MKVKTTYAVYGLLAAAVEGAPVVDTTYDYTGPAIPVGDWVDPTVNGNGKGFARLVEPPAVTPSTKNPTNNVNVIQLSYLPNGINIHYQTPFGLGVSPTVFWGTTAGKLDRKAQGYSRTYDRTPPCSLVAVTQCSQFFHDVQITGLDPGTTYYYQIPAANGTTTSQVMSFSTAQAAGDETPFSMAVLNDMGYTNAIGTFKHLTQAVDEGIAFAWHGGDLSYADDWYSGILPCESDWPVCYNGTSTQIPPGDYPTDYNDPLPEGEVPNQGGPLGGDMSVLYESNWDLWQQWVGKVTNKIPYMVMPGNHEAACAEFDGPGNPLTAYLNDDKSNATAPETNLTYYSCPPSQRNFTAFQYRFYMPGEETGGVGNFWYSFDYGTVHFIALDGETDFPHSPEYPFEADLKGNETHPTEYQTYITDSGPFGTVDGPYSKVQSYQQYQWLVKDLESVDRTKTPWVIAMSHRPMYSSETSSYQKYIRNAFEALLLEHEVDMYLAGHIHWYERLWPLGANGTIDSSSIIGNNTYLTNPGTSMTHIINGMAGNIESHSTLDADEPIKNITNVLDQEHYGFSKLTVYNATALKWEFIRGDGAGVGDSLTLLKRGCYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDF0</accession>
    <name>A0A0D2BDF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237179.1">
        <property type="nucleotide sequence ID" value="XM_016378502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDF0"/>
    <dbReference type="GeneID" id="27331237"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04154"/>
    <dbReference type="HOGENOM" id="CLU_1594550_0_0_1"/>
    <dbReference type="OrthoDB" id="4120143at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025061">
        <property type="entry name" value="Diedel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13164">
        <property type="entry name" value="Diedel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="157" mass="16910" checksum="AF4E58D30C175F23" modified="2015-04-29" version="1">MVSAYCCSSPAFCADGSESSIWECCAYGSCNIFCCNCDGGCITASKKRSWTDWGHGRGCSPFPGAFDADEVCPATISDDQCVIDKLDALDGNLDGRVSLAEVLASPDIVRPLITQLDLDPEDIKVKMTELFNIFDTNKDGYLDLAEASARQVVKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEV4</accession>
    <name>A0A0D2BEV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237371.1">
        <property type="nucleotide sequence ID" value="XM_016378694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEV4"/>
    <dbReference type="STRING" id="91928.A0A0D2BEV4"/>
    <dbReference type="GeneID" id="27331429"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04346"/>
    <dbReference type="HOGENOM" id="CLU_068979_0_0_1"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="228"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="332" mass="35909" checksum="B04B44B75DE16912" modified="2015-04-29" version="1">MNNTDPSHRRGVIGDPEGSFWLYDSTKGFDLTHPATPTSPCPTPNHTLKTNTLPVTVASSKTALVIVDMQNFFLSPSLGRPEDSKGLFAQHQLLTYAIPAARKAGIRIIWLNWGLTDAEIKAMPPSTLRAFGFETVLAPDFESYATASANQKRAAIDSHGVNQGCDSFPDAQIETSSGKNPRLYKGLGTDIGPVTLQGKTTVDGGRLLMRDTWNADLTSELRASYEQGLTASPPDVWIHKNRMSGLWGPRTMCTDFLEKEGITTLLFAGVNTDQCVGGSLQDAFSRGYDVILLSDGAGTTSPDSSQESIEFNCARTWGFCTTCKDFAESVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF28</accession>
    <name>A0A0D2BF28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230165.1">
        <property type="nucleotide sequence ID" value="XM_016386033.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BF28"/>
    <dbReference type="GeneID" id="27338808"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11725"/>
    <dbReference type="HOGENOM" id="CLU_242146_0_0_1"/>
    <dbReference type="OrthoDB" id="3989227at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="910"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="945"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1030"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1069"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1102"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1135"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1166"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="213"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="5">
        <location>
            <begin position="753"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="6">
        <location>
            <begin position="918"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="847"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1205"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW09949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1661" mass="185450" checksum="FCA195B14B856A51" modified="2015-04-29" version="1">MQRGPDLRTFTGILGHDEATTPSNFVSDMQTTKSKTHPVCMRCNSSRLTCTYDTSATLELPENQSGVVIQSASLSSAALPRENESQARSQRVSLERPTTRQNSSEKGRLTAFAGGRSVYTPATYWANPLMPKDSNEMDDNDDVPDESSNFVRWPPASEDHSGWAGAKFRPPRSSTLWTGASSNKCKFCGRNYNVSCVMALLPTREVCEKLCRLFFSTVFPLMPLLHLRSFGEDFGEFWEGTRTGNMHNSEPSLLLLKKPGFLCLLTSILFSALSSASKSRVKLLLGDSNVPDTGEMYFAAMVSASLTGFPRRPSIYSLAAYLFAQSQFVREEEFSDVPDFIATSFRLALGMGLHRQFSDVGFTRAEMETRRRVWWYILHLDVMSSASSGLSPLFIDKKMANTDEISPHDCVEGGSNVNTEVDVRYVVALQRYKVTKEIREVLKYHFEDHFQSLDQVNEVAKQLKDVANSVKSTVETLLRSTPASSRPTRVAEGQNLKGRPFDRAWSLRLDADDKEVVDFSAWAVFLLHLMVHKAYCVLYRPLFRDQAMSVHDVIRMNAIKHAQAFIQLFIRVCNDPSSEPYHWMYPGTYQPLQAVATLLADLLQHPHSDHAPLSRGLIDAVFELYRVDEGIVSREEPPQRQLSPAGKDAWTMLLRARRKALAQIGADHHVLHPSPTISSNSCICGDQIVQDTSAAPSSQQHSSRELSPVAPEESPRDLFHVEADQSNLSPGMLSQMNFDWRAWDNALDPSIVVSLQVARSNIAYPARILLFCLHGLGTVFGLAYNSNTPDLYPNTSHPSLAWTLWAIAIFEAVVSVVKSVSRSPSPKSTFHASHDRHPLMSSSRLFQDSDESLDHDRRSTRDPGESSPRRNLTFLPSRRQRRTFSWRTGWSRTTLSSRLVRIGASASTNLLITMIILAFVSFCTGTVTMAGIFKGINLFNGLAHFIKGGVFFFFGIVTVLRCIGCFSELGWAWNLKVTTKPPSRKPSRPFTMEGLECLLIFIYGITNVFLEHLSGWGGAWTAQDLEHVAISLLFIGGGACGLMAESRASRESVEDSLALEEKQNTIPGYSTNPVPTMIIFLLGVILGGHHQDTMESTMMHKWFGNFLTGASIMRAITYLLLYITPAKSTSPSRPPSELVTSFCLMSGGLTLMASNRDTVDAIIENHVPAMVVATVIMGISAVLMAWCFILVSIREWAQGRENLRTIESETPRGTPDTDDTASLEGRRVQSKSLESEKVHFESLASQEIQSASLEIQKLSLSLSLDLSDVFVRFLDNYIPRDQPLVPTGHRPQLSWLQAITPPRANDASLDSAILALSLVCLGRKHGDERLRREGTANYGRALHRLQDILSRGNLLFEEQTLASCMALSTFELLEVSGHNTGGWASHIEGIARLIQLRGPELHVSGLSHRLFLDFRSSCLTYSLATRRSTFLAQPDWLTVPWKVHPKSDLDRLRDMMAQLANLIAENERLDATADEKRAGIIGRGQELQSQLDTWHGDLTRKHPGPLYYERPSSAPFLSRFASVFPTALHFQNFGIARIMVNYWAVLLLLYNGIPAATDEFARRQRQVLDLARMIVQSMEYLISDDMRVLGPQTVFFALRLTMHVFTTAGEPDELDRCREVLEELDRRGYPFGKILSSCAWDDIPALLSGKAISSDLRTHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BG13</accession>
    <name>A0A0D2BG13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237731.1">
        <property type="nucleotide sequence ID" value="XM_016379054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BG13"/>
    <dbReference type="STRING" id="91928.A0A0D2BG13"/>
    <dbReference type="GeneID" id="27331792"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04709"/>
    <dbReference type="HOGENOM" id="CLU_058677_1_0_1"/>
    <dbReference type="OrthoDB" id="5384020at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="258" mass="27522" checksum="51A253058C402C48" modified="2015-04-29" version="1">MSSQNRPSSPAPQHRRRSSFIDMFNPRSNTTNTGLSSSPPTNTSSTPNTNHHRRGTSITGLGLTTNPSGQTPFSAFQRRASIATSSVSSSPDFKNSFGDEPAVIEEDDTTTQAIGQPPSPSFARRVSFGAQALRDVRMGSSPGSAAGGGRRPSSSLFTLVENSNSENATPSRPSLTGTAKTTEGFNWSEALRDRSRRSPSFSSGNPFAQGASRPRSGSISTPEPPKEIPKAVEPPAPARMKKPDHLGERMLRGDFMMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BG14</accession>
    <name>A0A0D2BG14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230530.1">
        <property type="nucleotide sequence ID" value="XM_016385586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BG14"/>
    <dbReference type="STRING" id="91928.A0A0D2BG14"/>
    <dbReference type="GeneID" id="27338359"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11276"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="203"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="353" mass="40696" checksum="DF7627D459C1EB25" modified="2015-04-29" version="1">MSSTATQEEDSRTITLTNGKTFTFDSNASTTDEAIPVIDVSRMYSDKLEDRKAVAEEIREAAHGIGFLSIINHGVDMKLAQDVMDEAKSFFALPTERKMEVCTDLMPDEYCGYHPMQHYNPNGWKKRDLYEAFNWNYNAANDPDFPDESISEINLWPTELPGFKKILCTYQTEMIRLARKLTRMFALALHIPEDSFEDMVQRPEAGCRILHYPQQETSRDEQNGIGAHTDVEYFTIITADAEGLEVLSKSGRWIKVKPIPGSFIVNIADCFMRQTNDFFVSTVHRVINESGRERYSVPFFWGFDRRSVINPIPTCVSEDNPNKYEIMTAGEYYLWRTRRQKIMWKIGEGQVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BG28</accession>
    <name>A0A0D2BG28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="4">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="4">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ6</name>
        <name evidence="6" type="ORF">PV08_11286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="4"/>
    <dbReference type="EC" id="1.14.15.46" evidence="4"/>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230540.1">
        <property type="nucleotide sequence ID" value="XM_016385596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BG28"/>
    <dbReference type="STRING" id="91928.A0A0D2BG28"/>
    <dbReference type="GeneID" id="27338369"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11286"/>
    <dbReference type="HOGENOM" id="CLU_009665_8_0_1"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000245">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0274">FAD</keyword>
    <keyword evidence="1 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="43"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="357"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW10324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="533" mass="56581" checksum="4F8D4726AA6B7ADA" modified="2015-04-29" version="1">MPTRLPRLRVSSSFVCAQCRKSLTSSKRRRLLSTTASATPEIYDVVAVGGGPAGLALLAALKSSPVTSHLKTALIELQDLSKHRQWASSSDQYSNRASSLTSSSVSFLESTGSWTHVEQSRVQAYDEMQVWDAANGASIQFDWASETKQYNAPPQTIATMCENANLTRGLLERIVELGAESSLLANTSVSSITNGEDDPEGLNLSSWPVVNLESKSSSSHTTSVAARLLIGADGFNSPVRAFAGINSSGWDYNRHGVVATLSVQDGPSTSSSHSPDETSDFDFDLFASEPLPNRATAFQRFLPQLGGPIAILPLPNGHASMVWSTTPAYATYLKSLPASGQLAMINAALRLSQTDLKYLFTLPSDSPDAHESELRWRLAHTDAPGIARQPPIVTGVQENSMASFPLRFRHATSLVNPRIALIGDAAHTVHPLAGQGLNLGLADAQSLATCIAYGVEHGMDIGDAMALERFSSDRFGKGLLMAGGVDALNSLYQIGASGDGMLASVAGRARGVGMKVINDLVPGLKGLIMKQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGQ4</accession>
    <name>A0A0D2BGQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238399.1">
        <property type="nucleotide sequence ID" value="XM_016376829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGQ4"/>
    <dbReference type="GeneID" id="27329554"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02471"/>
    <dbReference type="HOGENOM" id="CLU_289495_0_0_1"/>
    <dbReference type="OrthoDB" id="4153178at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="856"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="950"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="977" mass="106376" checksum="D545D3DA1CF57A33" modified="2015-04-29" version="1">MSSSPSSVKQRSPKRASPKRTPLAERTASQANEIIRSGRDGRLQQENTSIYNTTPFPTKAAHVLLPSSIKKRKDTPGSTPNFLGFPFDLDSGRTKDGPRSPQGAARQGVKLKRSVKALRDLYESQADDSSRPSTATSPPLRPSTANSTRLRSISSSESLSGAFSWDSLRKISTDDLALLPTLPAGRRPARRLSSRTSFTSTAERAGATSSPNYRVLGVTSSPRPQTFQDLSSAVLQPFEEDLSSSTAQDSSSSPNIVRLANTSSTEHLPLPELSSSPIVVKLGTSSPVGPRHGGFEYANFSRSSSTSSRKRKRSDTVGSTQTFAERAGARNPLASSPPLDPYIPTSAAASIISPDNGGFPSSAPQSIRLVEDSQDESSPVVRRIASSDLPSSDSSSLSGTHASLQAALSSSPPSRIQYPIVRAPPRSQEAGLVVPKRASRSMSTDGGRPVFASRLSAVPSEASRGIKTRSASVASSELELDVDDYLHSDDLAPASAYIINNAGNQSQIRIVLDQESETHEATDEVSALPSSDEVYKSPSSHPSYRGSFVYSPTSSQQSRLNSMKSFTQLRHQHSFLSRPTSSGSTSTVANGLPIPTWAKRYYSGFYHDSFNFLYASNSHANLHSLAQSPSRVPRPDESNAQLSVNGSPQRPRSFHQVVTERVEALLKTRSRPRVEARKSHIMPGVGPLVSNPVGEHPSTAALQQRRQTYSLSRQQTPAVQNHNRSLSAPLSPADPRAHWAGVVEIHQRPLPHGRSSYTIHHTHYRRYSNGEYSVSPSESQSVIHHPSPVHHRSSRRWSGSPHLHHDYRLNTGSTASRGFGFPFNSHSRWTAPSVITTRSAGFMPRANLRSTQVACFALGFVVPLAWFVAAFLPLPRRPSSYADLEKAAYANAISHAARGSERTSRQLYMPPEEALSDWEQLDVLARLRTERQLAGAAELKFQNARWWRNLNRWMCAVGVVVCVLVIVLAVLGTRGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BI40</accession>
    <name>A0A0D2BI40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cell cycle control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_02583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238511.1">
        <property type="nucleotide sequence ID" value="XM_016376941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BI40"/>
    <dbReference type="STRING" id="91928.A0A0D2BI40"/>
    <dbReference type="GeneID" id="27329666"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02583"/>
    <dbReference type="HOGENOM" id="CLU_025025_0_1_1"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="45964" checksum="D2522CBE97AD8BB3" modified="2015-04-29" version="1">MSQTDVVQTDSIHEEDPHNEPPKKQKSRRPANTAFRQQRLKAWQPILTPKTVLPIFFAIGVIFAPIGGLLLWASASVQELVIDYTDCNTTATTSFTAIPESKVSTSFKSSNSTARPLWRRTLNTTHPPYSVELRNTPVCTLQFSIPNDIGPPVYLYYRLTNFYQNHRRYVKSLDTDQLKGDFLSNHTIHDSSCNPLKLDHNGKAYYPCGLIANSIFNDTLNSPVAVSTSGGQESQQYRMTNEGIAWSSDASLYKRTKYTNFDVSPPPNWAVRYPDGYTDENPIPDLSKYEEFQVWMRTAGLPTFSKLALRNDNETMTAGTYQMDIYDFFPVTVYSGKKSILLSTRSVVGGKNSFLGIAYVAVGGLCIVLGVVFTIAHLIKPRKLGDHTYLSWNNDSPSTGVSTGREVRPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BI74</accession>
    <name>A0A0D2BI74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238879.1">
        <property type="nucleotide sequence ID" value="XM_016377309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BI74"/>
    <dbReference type="STRING" id="91928.A0A0D2BI74"/>
    <dbReference type="GeneID" id="27330035"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02952"/>
    <dbReference type="HOGENOM" id="CLU_068770_2_0_1"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="289" mass="32720" checksum="E4B6EC5EF2FDCEB8" modified="2015-04-29" version="1">MSKRKELGDKIVDKDAMVDDESGDDEDFDVLDVDFEWFDPQPEVDFHGIKTLLQQLFDVDAQLFELSALTDLILSQPTLGSTVKVDGNETDPYAFLSVLNLQEHKDKPFVGKIIQYLQSKAKSKPELTPLADLLSQATIQPIGLILTERLINVPSEVVPPMYTMLLEEIQWAIDDKEPYTFSHYLILSKTYTEVASKLDAEDDRPKKKKKATGGGFETMYFHPEDEVLHRHAICHGQYDYSIKQDEGHSDSKRAFQELGIKPQGHVMLISGDEFKAAVQDVAEYLKPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIK9</accession>
    <name>A0A0D2BIK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238636.1">
        <property type="nucleotide sequence ID" value="XM_016377066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIK9"/>
    <dbReference type="STRING" id="91928.A0A0D2BIK9"/>
    <dbReference type="GeneID" id="27329791"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02708"/>
    <dbReference type="HOGENOM" id="CLU_035063_0_0_1"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="30"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="350" mass="39283" checksum="BB46014955E351AD" modified="2015-04-29" version="1">MASNRVRIAVATNSLGKSAAGHDIQSKLLAAHSHGFDGVELAWECLEAHASSTLFSEESVRERRLCLAAEDIQRTASTLSLEIIALNPFGFYDGLTQEQDIQSRLYEAELWLQICDILNAPILQMCSCIYPLQKPLTPDKHHIASNIRRLGMLAQKYNKVVAYEATAWGIHVDTWQQTRDIVSLVNLPNVRLCIDTFHIAAREAGDPFNATAPIRIDGLRNLRQSLAEMRRTIKPDDIGYFQLSDATVADPNQRGYPRPDLNQPPYMTQSRNCRIFPCEPQHGGVLPVVEVAKAVFALGYRGWVSMEVFHVDMWRKDSSVPEEWARRGMASWRKVAQKCGLESPATNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIZ2</accession>
    <name>A0A0D2BIZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239109.1">
        <property type="nucleotide sequence ID" value="XM_016377539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIZ2"/>
    <dbReference type="STRING" id="91928.A0A0D2BIZ2"/>
    <dbReference type="GeneID" id="27330265"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03182"/>
    <dbReference type="HOGENOM" id="CLU_550978_0_0_1"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin cofactor biosynthesis C (MoaC)" evidence="7">
        <location>
            <begin position="118"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="495" mass="53971" checksum="21F15D8710A4DFD8" modified="2015-04-29" version="1">MSRIHWRHFSSSPTRSSAFARRWYHDSAPQKTGSRRVLSKNTFRYIRCQGDFRFLPTSEPENIPSFRSHTWSEARARVKTRKLSSQENVRHSSSSSSSEFDKDPPELNHLTTDGEAHMVSISGKVPTRRSATATTVLLFSDPQTYRALLAARLRKGDAIAVARIAGIQAAKKTADLIPLAHPGLCITGVRVHLEPFMSDQLPKPFTAGPLALGQDALKYGGVAVTATVDCEGKTGVEMEAMSAASVAGLTMYDMLKGVDKAMVLTATRVVAKSGGKSGDWVWDEKSNSIVKVGVAVDDNRAVDRAGPAATPKRRDTKTSLTNAIKADDDADVLRALEQQYHEIKNKKIASWTSHMQREIDNGVLMPNIHYHWARWPVTTTPPHSGSGSGGGGGGGRPDTKEERRASSTTTTTSSSPAVPNFATNEQHEQAEAVAVPVESKMARRAGDCEASDSFTTTLLRRGRVGTREFLSTRRQRLVDMLENGGVPLTTERGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKS9</accession>
    <name>A0A0D2BKS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239744.1">
        <property type="nucleotide sequence ID" value="XM_016374468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKS9"/>
    <dbReference type="STRING" id="91928.A0A0D2BKS9"/>
    <dbReference type="GeneID" id="27327183"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00100"/>
    <dbReference type="HOGENOM" id="CLU_011226_15_0_1"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="109"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26155" checksum="7D7B5F9EC87651EC" modified="2015-04-29" version="1">METLKPTLYHLSDSQSQRILWLLEELEIPYDLVLHKRVESGPRKRRAPEELKQTHFLGKSPQLATGDGRVIVESLVIARYLIETYDKEGRFKGEGDWIRDDELCNIAATSIGIPMVTEILFKAMATMSPFFVRPLVSLIHSGIHKGYTGAELELNLRYLQEQLGSSDYFGGTSPSRADFIISWPADNCVQNNIIDFSKFPSLAKWHQRCQNRAAWKRALEKGNGYDLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM13</accession>
    <name>A0A0D2BM13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240179.1">
        <property type="nucleotide sequence ID" value="XM_016374903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM13"/>
    <dbReference type="STRING" id="91928.A0A0D2BM13"/>
    <dbReference type="GeneID" id="27327621"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00538"/>
    <dbReference type="HOGENOM" id="CLU_008679_1_0_1"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="374"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="604"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="651"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="664"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="790" mass="85948" checksum="FE6624E74D8E3B78" modified="2015-04-29" version="1">MVVGSKRSATDAGFTSSSVEPTSKIPKATASPVQEMASITNPPSINMNEAHRNGMPQRRKVDVSADVRGGADQVDDAGWSVAESKSSRKKKRRKLREDSTVHPSINFLDTKPARVQLKALQDLVLYVLADGVAPTWLAVNNAKQIDKIVVLMIPGLDRATLEDRATLEAAISLYEQTLPQTPGAESVAAEAHVRDPPTIPDNVLLSDVPDSRGDVTSPLSPQSLLDHLLTHMIEVKAPGDSHANRVHSPLQGMLIAPLPPSSSTNPKNKHPEKSSHYTRTPISQFIHTADELREAEYPVHPAAFTNPQDAALEAARREATSQSLSHGWVDTSVVKSTPVLNASSQTDGTSSAAAHSRRRRTSASSRDPLTEGLKPYALDCEMVLTTDEKSSLARISLLDWSGSTVLDSYVKPDLPVKNYFTQYSGITESHLADVTTTLSDIQTRLLSILGPDSILLGHSLESDLNALKLTHPFIVDTSIIYPHPRGLPLRSSLKFLANRYLKREIQKEGADGHDSVEDARAVLDLVKLKCEKGPRWGTLDANGESIFKRIARSIRADGSNRHRRTAIVEYGTPERGFGKEATYKIACTSDDEIVQGIIRAVNGDCPADDSENGAARDGGTDKTADGQETTDQEIPEGGVDFVWGRLRDLEALRGWNNPPPPPTTTTTISTSEPNTSSEAAATTTAAAAAPAASEQTAESSESLRQTASRTLSRLLTLYAALPRRTLLMTYSGTNDMRPVLRLQQLHTQYRKEFKVKKWDELSVKWTDVEEQQLRSAVDVARKGVGILAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BND4</accession>
    <name>A0A0D2BND4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016374970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BND4"/>
    <dbReference type="STRING" id="91928.A0A0D2BND4"/>
    <dbReference type="GeneID" id="27327688"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00605"/>
    <dbReference type="HOGENOM" id="CLU_049351_2_0_1"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW20030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="225" mass="24694" checksum="C1222DB362150F69" modified="2015-04-29" version="1">MSRAFEVPTGQGKNVSIKICEPELRAQGLSLTTWTSSFVLARQLHTLDVQPSHSTSLPVLELGAGTGLVGLTAAAVWKTHVCSTDLAPLLPGIAANIALNLDCTEGRVDCGSLDWDSPELLKLENGSTLNPDNDPASVILAADTIYSEEHPELLSKTILRWLAPGPSARVIIAYPLRVAYLDYLRELWELLEAGGLEAFEEGKEQADVKDWDDECLIEWCVWRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNY1</accession>
    <name>A0A0D2BNY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240456.1">
        <property type="nucleotide sequence ID" value="XM_016375180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNY1"/>
    <dbReference type="STRING" id="91928.A0A0D2BNY1"/>
    <dbReference type="GeneID" id="27327898"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00815"/>
    <dbReference type="HOGENOM" id="CLU_033074_1_1_1"/>
    <dbReference type="OrthoDB" id="5317787at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="392" mass="44446" checksum="3466CBF872248539" modified="2015-04-29" version="1">MPRHYLVRSRTTRDSCSSASSASTCSQESDLSGRSSRTQYTSNTSYSYTKPTTKHSETCAEDVVVETTAVVEQNDNVDPRSSTETYASTIASERESDSLKGPCLLPLTRHLCYQPDAIACTPKEFAELFPSTRRILIQHDDTSPDGNLNLRADTEIPLSKGQKAKLTLFHLRMYDLGDRQFSLRRYQRQSGREVCSTKRKYLKPVAEPSTTFKRHPLTTALRKMSFRAQKPRPRPSPEVDEEGSDDDFELFAAQADIEATVPTDTIRIEFSNYAQVELDRSGRGDGKLYDFEYWGERYTWRKNVYQDGMESVFSFELVNLNTGACIAHITPDRLSSRQIRKEAAQGSWVPPCSMRILEKQISSDLGDVLIATGLMALTDDCIRKHWHEAHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPH0</accession>
    <name>A0A0D2BPH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_08161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233190.1">
        <property type="nucleotide sequence ID" value="XM_016382487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPH0"/>
    <dbReference type="STRING" id="91928.A0A0D2BPH0"/>
    <dbReference type="GeneID" id="27335244"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08161"/>
    <dbReference type="HOGENOM" id="CLU_044094_1_0_1"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000052">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="348" mass="39325" checksum="2456E5A9A7AE5FEC" modified="2015-04-29" version="1">MKVIKHCASRFPTVATGFITGMESNGTLEVTNCFPFPVVDLPPEAQYDQQHFNSAAAAPRAKSNTQYQAEYIRMLREVNADANNVGWYTSANLGNFVNTNFIENQFHYQKELNEKTVALVHDVSRSSQGIMSIRAFRISPQFMTAYKENKFTTENLLKSGLKYTDILVELPVTVHNSHLVTTFLQQIPKMLSSGVMRPPTSVAEIENNPIIKNDTLAPNFESLTISIDPYLSQTADNLLDSIETHHVEANNFSYYQRAMAREQAKIQQWQAKRKAENAARALSKQPPLPEDEWQRLFKLPTEPSRLESMLNSRQAEQYARQVDGFVAGTTGKMFAVRGNLLPNEAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ36</accession>
    <name>A0A0D2BQ36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241259.1">
        <property type="nucleotide sequence ID" value="XM_016375983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ36"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ36"/>
    <dbReference type="GeneID" id="27328705"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01622"/>
    <dbReference type="HOGENOM" id="CLU_071329_0_0_1"/>
    <dbReference type="OrthoDB" id="4159513at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="331" mass="37754" checksum="D67FA85C322D38FF" modified="2015-04-29" version="1">MVILGGLELVAAGYLLKEVAKDSKEEEEREQERRRRRRRRHSRDDHHHSHSHSGGRHDNSPPSRPGRPSQSSLYPPPNGPPRPYSAPPAQTGNPPYSGPPPPQPQGMMWPPQQQQQQQRPYPHPQGPPPNPGTWPLAQPQQYQQPQYPPWPAKPPPQQNIPQPNPNNNNFVPPPLQRPATVMLPPPNMHYDMKTGKWQNNMLPPEMFEGRDRETDRDLDRIHSHERLRRENTMPASTPHINVSPPVGHHSTSSLSLPQGVSELDSETPGRYRPYNSSNNNNNHGGEKNSYSYGPQRSERRRPRAHSGSSATTRYYDEDDDDMRDPPPAYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQJ4</accession>
    <name>A0A0D2BQJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233620.1">
        <property type="nucleotide sequence ID" value="XM_016382917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQJ4"/>
    <dbReference type="STRING" id="91928.A0A0D2BQJ4"/>
    <dbReference type="GeneID" id="27335675"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08592"/>
    <dbReference type="HOGENOM" id="CLU_015643_0_0_1"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14474">
        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="812"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="672"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="855" mass="94090" checksum="D5DDB1C6A91DB79E" modified="2015-04-29" version="1">MKFGDTLYQRSVPKWTAYNVKYNELKHLIKIRTSAGVVVPVGIPVQGKSKWEELENELYTLIEGEYNNVTLFLRSKQGEIERRLAYVEKQIKLAQRAVEDNALHKSIIQARKYRQLIKDVDGIGDEVQNLSRFAAVQKTAFRKILKKYRKWTGSTALQTRLDVEVFSSKKLQTDFSDYLQELSEQKAILTEELAGPMLTGRPGSPSSASDKQQKRISASMKRSSTTKLNEAVLRGSLAFDAAILTVPYGETAGSVFYWIHQDNLDETRALLLRHMRDASVSSTPSRNNSLESIASRKRPTLESDSNLLTHMAIFDNAYRYTKDQGISRPSRIALSSHWGSAPEAIVTLAGLSPTSSDSTMLTVSRKDLVSALQCDQTTSSTSENVHIVRKYLREHRDIQPLAHVHFARNRYLGLTNTTEMGIWATLDSNVTVTSVDMDHIGEPLPQTQTGDVFPYSILHIRWEAARIPPAARAFDESHLVERVEGFTLEDLAIHAVQKDLAEPSWHPLLQKDIRKVPTSPRMSRLGSASRSRLNVADMAGTSSGPSSTDGPQGSIFSAGTVEAVSVTSESAEQGNTGPSRVSAVANKPRRKKIARIKVPERAPSPVRYWNEFDDGDSDVNQGGGYVIYVDPDEPAFPGAEKMAQAFGALYDSLSRGTTKLVSWLPLHSEKGQDGFAGERSPLLSGENDDFDTSGSDTEGSIVQRSPRQANRRRQSHRPRSGTSTSYRPGQVLTPRQKALEQMLFMFYSGLIAISYVLLIMSSILLGTGRRKAYVEVDAGVVAGVVSAETCAIAATILIMMRRQQLSVLHWGLVAVLVSSVVVVGVALLSFMFAGVAPGSDKKGSGGKSARITGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQS4</accession>
    <name>A0A0D2BQS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_08677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233705.1">
        <property type="nucleotide sequence ID" value="XM_016383002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQS4"/>
    <dbReference type="STRING" id="91928.A0A0D2BQS4"/>
    <dbReference type="GeneID" id="27335760"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08677"/>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_1"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW13489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="471" mass="51647" checksum="B9A78345F156746C" modified="2015-04-29" version="1">MASSLRVGSSLLRSTSVTSKPFVQKAAFNGVRCASTKTLKDTFADKLPGEIEKVKKLRKDYGSKVVGEVTLDQVYGGARGIKSLVWEGSVLDSEEGIRFRGKTIPECQEVLPKAPGGEEPLPEGLFWLLLTGEVPSEQQVRDLSADWAARSDLPKFVEELLDRCPSDMHPMAQFSIAVAALEHTSEFAKAYAKGINKKEYWTYTFEDSMNLIAKLPTIAAKIYRNAYKDGKVAPIQKDKDYGFNLANQLGYGDNADFVELMRLYLTIHSDHEGGNVSAHTTHLVGSALSSPMLSLAAGLNGLAGPLHGLANQEVLLWLTKMKETIGDDLSDASITKYLWDTLNSGRVVPGYGHAVLRKTDPRYVSQREFALRKLPNDPMFKLVSQVYKIAPGVLTEHGKTKNPYPNVDAHSGVLLQYYGLTEANYYTVLFGVSRALGVLPQLIIDRGLGAPIERPKSFSTEAYAKLVGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR35</accession>
    <name>A0A0D2BR35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TMEM14 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233895.1">
        <property type="nucleotide sequence ID" value="XM_016383192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR35"/>
    <dbReference type="GeneID" id="27335953"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08870"/>
    <dbReference type="HOGENOM" id="CLU_096652_3_0_1"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF15">
        <property type="entry name" value="UPF0136 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03720)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="10327" checksum="3338232E2EF70A60" modified="2015-04-29" version="1">MASETPAYIISALTSIGGVTGYVRTGSVPSIAAGLTVGALYGLGGYRISKRQPYGVELALLASVILAGSSIPRAIKTGKPLPAGLSVLAATGLFIYGKAFLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR82</accession>
    <name>A0A0D2BR82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241729.1">
        <property type="nucleotide sequence ID" value="XM_016376453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR82"/>
    <dbReference type="STRING" id="91928.A0A0D2BR82"/>
    <dbReference type="GeneID" id="27329176"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02093"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_1"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="423" mass="46010" checksum="A12D285A859B3421" modified="2015-04-29" version="1">MSEVTVLIIGCGVAGPVLANLLKRKGYSPIVFEKVSKLGDAGASLMLMPNGLKVLNLVGMAEEIEKGSQPLDAYEDLTSDGEILGFSDLPQSFRSKYGSPAMGVKRTELNLMLKNMLTDLNVEVREGWELEDIEEGENSVTAHFKGHGSVTGSFLIGCDGIKAASRRILLSKRGISEGLPDFSGLTQTAGLSPTPKALKTRYSMRNWFGEGVHMIAYPVSPDVTSWALTLPEGEGNEADWGLCSPQEISTRKEKLLAKISSWKDKSPAELVQNPSRIIKFGLFDRTEMSPDQWHSRRIVLVGDAAHPTSPHLGQGANQALEDCFHLSRALPYLIPGSDDYEDGLRKLGPGLVNIFQAFAEKRQPRTSALVKGAHIQGQTRVVTTGPDDCAKRNDKVAAGWKDVDAISAKYDALCREPFQGTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRU3</accession>
    <name>A0A0D2BRU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241341.1">
        <property type="nucleotide sequence ID" value="XM_016376065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRU3"/>
    <dbReference type="STRING" id="91928.A0A0D2BRU3"/>
    <dbReference type="GeneID" id="27328788"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01705"/>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW21125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="296" mass="31412" checksum="86DF197DC8321F71" modified="2015-04-29" version="1">MASASIPFKRLVRFIPRSDSSKIFIGQPHDDTLDVGLALRNGQDVKVDVFSGTSVLSPGQATGTSAVIDRVLSPLHISEVGTIRCVGLNYKQHAAEVNMALPTVPTVFLKPATALGDPWPAPTVLPKLTQLDDCGDYESELAVVLGRTAKNVPESEALDYVLGYTACNDVSSRTSQFAQSQWSFSKGFDTSCPLGPTLVSPALIPDPSKLRVRGVKNGDQLLQDCGTDDLIFSVAQLVSFISQGTTLPAGTVIITGTPAGVGVGKKPKVTIKAGDEFHVEILPHIGTLVNVFENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BST6</accession>
    <name>A0A0D2BST6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_02060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241696.1">
        <property type="nucleotide sequence ID" value="XM_016376420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BST6"/>
    <dbReference type="GeneID" id="27329143"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02060"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW21480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="510" mass="56264" checksum="E9D92CCD93A560D1" modified="2015-04-29" version="1">MGAFNRGYAKSLQGLPLQSAITICSAWAFTLFGYDQGVLGGLIALPSFLRANRINPDNADIQGTIVAIYDIGCLTGCIIAGFVGQKLGRRVFIVIGGALLVVGAGLQAGAHGASYLITGRVIGGVGMGLTTTMVPIWVAETSKAHSRGALIATQLTIVILGLTIAYWFDYGMLQHHPNTEAVWRLPLAFQVVFILLTWATIFLLPESPRYLYANGAVDDADDIMSRIYAVPVDSEEVTKHRADVFAALEAEKEYSFGLKNLFYDTSPVNTTWRLWLGVLTQLFQQMDGNNIVSYYATYLFINSLGMSQNQAAITSGGVTLLFLGGTATTIWTVEHLGRRTVMLYGAIFCSIFMILFTIGLGVNTDPSLKLAVVSIFLFEFVFGASWCPLVWVYVPEIAPLHVRHIGTAMGVFTQWFITFIVVKFGPMGIQNIGYRFYILFCVFNVLAIPFVYFCVKETKGLSLEEIDVLFARKEYKHVLQARLRGDHEAADKKQVQEKEDVVEEQKVDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BT85</accession>
    <name>A0A0D2BT85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241836.1">
        <property type="nucleotide sequence ID" value="XM_016376560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BT85"/>
    <dbReference type="STRING" id="91928.A0A0D2BT85"/>
    <dbReference type="GeneID" id="27329283"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02200"/>
    <dbReference type="HOGENOM" id="CLU_054590_0_0_1"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="256" mass="28374" checksum="D7C4EA0325E09524" modified="2015-04-29" version="1">MSHTQSEACCNTPAVVSTGYHEKGQWITVDGLKTYATGPSSVSQGILVVYDIFGFFAQTLQGADILAHSDKDHQYRVFMPDFFEGEPADISWYPPKTEEHGRKLGEFFQTKAAPPKTVARVKSVMDELKSANPGIKEWGVVGYCWGGKASIPIHIVNLVSGSNTVFKAAAACHPAMVDPNDAPNVTIPMCMIPSKDEDESAVSQYESKLTVPKQIEWYKDQIHGFMAARADLEDEKVRAAYEKAYRTLLGFFHKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BTK1</accession>
    <name>A0A0D2BTK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCA7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234765.1">
        <property type="nucleotide sequence ID" value="XM_016381663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BTK1"/>
    <dbReference type="STRING" id="91928.A0A0D2BTK1"/>
    <dbReference type="GeneID" id="27334416"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07333"/>
    <dbReference type="HOGENOM" id="CLU_044734_0_0_1"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="174"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="370" mass="39987" checksum="FB5ECA3BAAA1C0B5" modified="2015-04-29" version="1">MSSLVAASGYDFSKADRKLGKKKLKSTAQIKKEKETNGVKNGGSQAPSPDVPKFDEETMANFPNGKQEPLETLVCKHCKKVILKRTARGHVALCLKTKQEKARKKKEAREAAQRAKERAERADDDDDDDDDSKGGDRKANAEDDKKSKKRKAEGDDDKEPKKKKTKKEEAKAKAPKPKGPVDVEKQCGVTLPNGAQCARSLTCKSHSMGAKRAVPGRSLPYDMLLAAYQKKNQARQQKAAIDANAPALLDDDIDPALAGPVDSDEEKDAVMSAIARSLANPQPLVTQPLIPRKRLYQMVRFREQLSNAMSGNRGAGLFSVPADSARITIPGSATNESFPQSLSASSAPTGVGMAQPGLRATPRKTSIDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BTL2</accession>
    <name>A0A0D2BTL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_07348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234780.1">
        <property type="nucleotide sequence ID" value="XM_016381678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BTL2"/>
    <dbReference type="STRING" id="91928.A0A0D2BTL2"/>
    <dbReference type="GeneID" id="27334431"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07348"/>
    <dbReference type="HOGENOM" id="CLU_026016_2_1_1"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF7">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="56408" checksum="929874A25BC9854E" modified="2015-04-29" version="1">MNDPEKGMSTDTSKAVDPPPVGLDDDHEQGLGKGELQVIRIRDGSSLLRKLRQAEVWMDRKLRIEGMGAERIPENERKPPRMMLFWFSMLMSPGLLTMGILGPIFGLSVNESIILSVFASCIGSVIPAFTATLCAPLGLRQIAASRYAFGIWGSKFCGLLNIIVNIGFGTINCIVAGQLLSAVSGGSLTIVVGIVVVCVGSFVISFFGFRLIQKYESVAWFLIFIFLCVEFGQSAKYFSPTPGLSYVSGSDRTGAGLTYFAIVFGEAAAWCSMTGDYYVHYPPDVNKWLVFGMTWMGLALPTIFVLILGNYYGGIVNTNETLSQVYDDGGIGALILATMEPSGWAKFVCVMYALSFLANLTAIIYSSSLSIQLWGKHFLAVPRFVWNTLLTAIALGLAWGGRDHLETILNNFLSLLGYWTICFGGVLAIEAFWFRPRLGGYDKEGWQDQSRMPLGLAGCSSLALGIGVSFLGMDQTWYVGPVAKLIGSGGDLGNEFTLVAVALSYPILRQLEIKHFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BUC6</accession>
    <name>A0A0D2BUC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diacylglycerol O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235090.1">
        <property type="nucleotide sequence ID" value="XM_016381988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BUC6"/>
    <dbReference type="STRING" id="91928.A0A0D2BUC6"/>
    <dbReference type="GeneID" id="27334742"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07659"/>
    <dbReference type="HOGENOM" id="CLU_024469_1_1_1"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="51679" checksum="48A6FFF482A7A363" modified="2015-04-29" version="1">MSRAGPDSVLRPLGIFEKFMVTRSQLGVYHKVGVTAFYSFDRKTTTHSLRSVLYSALALVISRHANLSITPVDPDSSEPYFARLPYVDLDEVVTFTEIDDVLDGQGRHHPVLDGFLEREHSRPWDLEVPLPLWRLHVLQQPGDESRFVLSYMFHHAVGDTKSALVFHQALENSLNNPTETEGPSKVVSPNLPLVPPLDAFVDTTRVVDGNGSEEPDGLWTGARQFLPVRTKCRSLRFGANDSAEFLRMCKGHGVSLTAAIQAMLVMALFEKVPSEYTALKTDCPISLREWLPPPVSALSMGIFVDTFLETHRRSDFLVDGAKGPFAWVHDAQRTKRRIDRAVRERRGDGLLEKLVYIKDVRALTMDKMGQPRVTSLELSNVGKLPSLKEDRRAMIQGLVFSQSAGAVSGAIKVSCVTGRDGRVVLGFTWQEGVVEDVFMDGLVEEFQAILDQDLQCFQKTPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWG5</accession>
    <name>A0A0D2BWG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235820.1">
        <property type="nucleotide sequence ID" value="XM_016379993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWG5"/>
    <dbReference type="STRING" id="91928.A0A0D2BWG5"/>
    <dbReference type="GeneID" id="27332735"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05652"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW15604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="496" mass="54552" checksum="1DEEDF5A85FA6626" modified="2015-04-29" version="1">MENEKSVNEGYAPEQDRRVSVHTAPLDATPKTRWERSWPTIACGAGLFSDGYLNGVIGSVNTMLRILYKDEYVNSSAQSNVSSIAFAGTVLGQLVFGYLSDHWSRRHSLLLSTIILIVFAALGAGSYGAGGSIGGMFAALAAYRFLLGVGIGGEYPAGSVACAEATGELKHGHRNRWFICFTNLAIDVGFVVSSFVPMIMVLIFTESHLRAAWRMCLGLGVIPPLSLLYLRIKLQEPEEYNRNKMNRYPYWLIFKFYWFRLVVVSLIWFVYDFSTYSFGIYSSSWLAFLLPSDAPLWKTFGWNTVINLFYCPGAIIGAFLSDILGPKYCLILGVTLQGIVGFVMTAIYKHLDQPSQVGGFVVMYGIFLALGEVGPGDNIGLVASKTSATSVRGMYYGFAAAMGKVGAFVGNYIFPDIIKAAGDDVIKQGQYPFYVSSALCIFSALVALFCLPNIGQDTITEEDERFKAYLIKHGYDVDTLGTKKFREEKTSLATSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BX47</accession>
    <name>A0A0D2BX47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236090.1">
        <property type="nucleotide sequence ID" value="XM_016380263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BX47"/>
    <dbReference type="STRING" id="91928.A0A0D2BX47"/>
    <dbReference type="GeneID" id="27333007"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05924"/>
    <dbReference type="HOGENOM" id="CLU_003953_5_0_1"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="319"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="807" mass="91941" checksum="2DD44F9F2575671A" modified="2015-04-29" version="1">MTFQFSRLVPPAAGSTNQRQRQRLRRRQSQQVRASSPALASSSASTPTSPRTRNTNNNTNLSSTPVSASTTHDLSMSSSEPVDGPSTNATIISLTKKFRTLGRLSPWVKSGELRTPPEESYICDTCLRLDLRVESFCVQPGDNEYERQHKFRYLGRLSQIRRKTHCPFCRLILAIADRPFDQRTPSLHADDDPVCYARWVVDGQEDVGPDPARPGEHIFRPKTRRLLIYSEPQAFKDGYIVLLADDAPSREFFGRRITSPDLLDAEVLRRWIHVCESTHGEECEESLVHPDLLGKPKNVFRAIDVNNMCIVSVPQSSRYVALSYLWGKNFIQLFTTSKNLPKLSQPGALEKEKLPRTIKDAIRLTKMLGERYLWTDSLALLHDDGFQYHDDWVYARATVTVVAGSGKDANAGLPGVRKESRTFHQDIEEVKPGLRLMVSHLAEDYISTSQWDSRAWTFQERMLSRRCLLFVNGRIYYQCRRTTFCEDIEMPKGNGWSLDSIDMPTRIFRERPFVQYTSAVELYTRRELTNPADILHAFEGVQLVLEKRIGANIYYGLLETMMDSSLTWESNKRLLRRPGFPSWSWAGWVGEIQWKYTEPARSWIEWHADQADGIHTFPRQTLERIPPPIERAGDDQPMSSHNLSKTIPLLHFRTVTAHFALTSPALIHKSVISPLRKRLTGPSALSTVRPAPADPGLIRVGIADKNGLWCGTIDLDLTWMNRAGRSFEFLIMSKVSRFTDDELNIWEGTLPDDVEDILTGRNYGVYNVMLVSKRAGIYYREGLGRILAESLTRVLEPGPEWKDIVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZL2</accession>
    <name>A0A0D2BZL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03979</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Golgi apparatus membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237005.1">
        <property type="nucleotide sequence ID" value="XM_016378328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZL2"/>
    <dbReference type="STRING" id="91928.A0A0D2BZL2"/>
    <dbReference type="GeneID" id="27331062"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03979"/>
    <dbReference type="HOGENOM" id="CLU_074845_1_1_1"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="188" mass="21161" checksum="3EE3819A6BB787C0" modified="2015-04-29" version="1">MADEPGSLNWRLSAHPVTLLTYLGFRIGSLLMYLFGVLFIPNFVLVFILTLLLLSIDFYYLKNIAGRRLVGLRWWNEVNTSTGDSHWVFESAPEGTRDQNKTDKRFFWLSMYIGPALWVALAILAIVRLQNLIWLVTIAIALILTITNTVAFSRCDKFSQASSFAGTAFLGSGIARNLAGNMVGRFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0J9</accession>
    <name>A0A0D2C0J9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237395.1">
        <property type="nucleotide sequence ID" value="XM_016378718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0J9"/>
    <dbReference type="STRING" id="91928.A0A0D2C0J9"/>
    <dbReference type="GeneID" id="27331453"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04370"/>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_1"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="143" mass="16090" checksum="4A54F99127C40F6B" modified="2015-04-29" version="1">MSAPQSVQCFGKKKTATAVAHCKKGKGLIKVNGRPLSLVQPEILRFKVYEPILIIGLDKFAEVDIRVRVTGGGHTSQIYAIRQAIAKSIVAYYQKYVDEYAKNQLKQALVQYDRTLLVADNRRCEPKKFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C1K2</accession>
    <name>A0A0D2C1K2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PV08_04728</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237750.1">
        <property type="nucleotide sequence ID" value="XM_016379073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C1K2"/>
    <dbReference type="STRING" id="91928.A0A0D2C1K2"/>
    <dbReference type="GeneID" id="27331811"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04728"/>
    <dbReference type="HOGENOM" id="CLU_000288_2_1_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="7"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="279"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="379"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="523"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KIW17534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="673" mass="73555" checksum="E59F95889A88CF27" modified="2015-04-29" version="1">MDPEELYTKQNCIGGGSFGKVYKGVDKRTGHAVAIKIIDVENAEDEVEDIIQEISILSELQSPYVTKYHGSFLKGSDLWIIMEFCSGGSCSDLMRPGMIHEDYICIILRELLMGLEYLHGDKKLHRDIKAANVLLGQNGQVKLADFGVSGQLSATMTKKNTFVGTPFWMAPEVIKQSGYDHKADIWSLGITAIELAQGEPPYADIHPMKVLFLIPKNPPPTLQGSFSRTFKDFVELCLRRDPRERPSAKELLKHPFIRKAKKTTYLTELIERNERYIATHGSRSSDDEDEDEVPAQQSHASENEDLWDFGTVRPVGGRGAGLRPMNDSDANARASAEPPASRNKGEWDETVKVPSSPQKSPVKGAFPTPAKAPLPPSPTRETSSSGAPVPSQLSTPAIPPKSSTPLSVPQTPANPVKTQVSTSQEHKDSPDSNEYNKAFQAQLAKDMAFLKIDGSDSPTSQGSTPRNKKPHMVIPEIPPFRGKPGRGEPLNPAKPAAPLTTVAQQPLPSFSTKDLAPVPGSQLGISSTDQPPSQPLTSKTNKPTPLTQPTSGGPSHQHSKEDPNDELTALNSVIVPALEAAIHRRSYMLKELSRTRQQGSPAAAEIQHQRVQTHEKVRRLAAKAAAIFQEIQRCDEEFPVGMSGGVTEFLEGFLEEILVRVEAAEEPESPKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C236</accession>
    <name>A0A0D2C236_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_04914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237935.1">
        <property type="nucleotide sequence ID" value="XM_016379258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C236"/>
    <dbReference type="STRING" id="91928.A0A0D2C236"/>
    <dbReference type="GeneID" id="27331997"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04914"/>
    <dbReference type="HOGENOM" id="CLU_081098_0_1_1"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000019">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="194" mass="22347" checksum="0FA093D402461368" modified="2015-04-29" version="1">MGVQKKTRKFAQVKRIIGQRDARLKKNQDTNKPADKKKNDDDVIREVPQVSSALFFQYNTALVPPYSVLVDTNFLSHTVQKKLELLPTMMDALYAKCTPVITDCVMAELEKLGTKYRIALRIARDERWERLKCGHKGTYADDCIVDRVQRDKIYIVATNDRDLKRRVRKVPGVPIMSVARGKYVIERLPDAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C675</accession>
    <name>A0A0D2C675_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239235.1">
        <property type="nucleotide sequence ID" value="XM_016377665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C675"/>
    <dbReference type="STRING" id="91928.A0A0D2C675"/>
    <dbReference type="GeneID" id="27330392"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03309"/>
    <dbReference type="HOGENOM" id="CLU_010595_0_2_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37475" checksum="B87E94A55EF7C1E9" modified="2015-04-29" version="1">MEHHQHGEPIEPDSQSDEGYDTATIGSDMTSLKSSVMNYQFENGRRYHGYQAGKYMLPNDDKEQERLDVLHHVFRLTLGGDLCLSQPSLKDPEKILDIGTGTGIWAIDMGDEYPAAEIIGTDLSPIQSTWVPPNVRFEIDDATHEWAFPHESFDFIHIRCLAGSIKDWPELLRQAYMHLKPGGLIELSEGRPHMCCDDGTYSEESATYRWVAEFYRISRGAGLEFDAFPQYADFLKEAGFVNVKTHEEPVPIGTWPKNKRLKEIGMFFEHQFLEGAVDGYSLALFTRLGGWSEIETQMLLAQVRTETKSRKMHLYTHCSYATAQRPLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6Y5</accession>
    <name>A0A0D2C6Y5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 21">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 21">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PV08_03633</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Does not play a role in the biosynthesis of MPA, but is involved in self resistance to MPA, since MPA acts as an inhibitor of IMP dehydrogenases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 21">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 21">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 20">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 21"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239555.1">
        <property type="nucleotide sequence ID" value="XM_016377985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6Y5"/>
    <dbReference type="STRING" id="91928.A0A0D2C6Y5"/>
    <dbReference type="GeneID" id="27330716"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03633"/>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_1"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 21" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 15 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 17" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 15 18" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 15 21" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="138"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="201"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="15 16">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15 16">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="295"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="345"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="385"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="408"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="433"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KIW19339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="549" mass="58744" checksum="E5C44C2C9543A443" modified="2015-04-29" version="1">MPIANGDAASNGVPLNRDVEKLDWRKALQVLEEYETRDGLDVHTLLDAKKNGALTYNDFLVQPGYIGFAASEVSLDSPVTKRISLKTPLLSSPMDTVTEENMAIHMALLGGLGVIHHNCSAEDQADMVRKVKRYENGFISEPIVLSPKTTVAEARELKEKWGFGGFPVTETGELKSKLIGIVTTRDIQFHPQPEDLVTEVMSKDLITAPAGTTLLEANELLRKSRKGKLPMVDKDGNLVSLLSRSDLLKNLNYPLASKLPHSKQLIAAAAIGTRPDDKNRLQKLVEAGLDIVILDSSQGNSVYQIEMVKYIKETYPELDVIAGNVVTREQAANLIAAGADGLRIGMGSGSACITQEVMAVGRPQAAAVFSVSSFAARFGVPCIADGGIQNVGHIVKGLAMGASTVMMGGLLAGTTESPGTSFLNREGKLVKAYRGMGSIDAMEDKKAGGGGKDSKASNAGTARYFSEGDRLLVAQGVSGSVLDRGSVTKFVPYLIAGLQHSLQDIGCKSLVELREDVSRGKVRFELRSVSAQAEGNVHGLDSFDKKLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C9C8</accession>
    <name>A0A0D2C9C8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1776-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240405.1">
        <property type="nucleotide sequence ID" value="XM_016375129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C9C8"/>
    <dbReference type="STRING" id="91928.A0A0D2C9C8"/>
    <dbReference type="GeneID" id="27327847"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00764"/>
    <dbReference type="HOGENOM" id="CLU_022136_0_0_1"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="55590" checksum="6CCCEF1403B01ACE" modified="2015-04-29" version="1">MTSDDQQFLDLLASIPQDMAAYGSRIADYIEKHTNAIASDIRDAIDNADWIPDSLRPPRQPASGPSYFPRPPSPPQGLLEKTTTWVSKNRTIIAVCVAFAGTTLFMIHRRKKAHARKRRAKKLPNGGKKEIVVLACSTFHDALTRSLALDLERRGYVVYVTVSSTEEDSLVHQEAKPDLRPLWIDLTSTVPNPAVDVHPNLEPIRELLSHPVQTQNHMSLAGIVVFPGCSGYAEGPLALLPPSDIVDNINTRLVSPVLTVQQFLPLLANHSVDPKSPASIVIAYPSIPNSLSPPRQIPECLVTSSLSALASSLKRELKAASANITVSELKLGNFDMGSVTSSRTTPTQSAYHASNTPGASSALMPWHSSQRAALQRKTLGQRSFIRGASAREFHNAVFDALAPPQTFKAFGRFEWTATRRPGVVFVGTGARIYDVVGRIMPDGLVAFMMGHRRREDDETDVRQARVRHFAQNDQRRRDSSGGSAERGPAASTVWGFGSAGSESGIWEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CBC5</accession>
    <name>A0A0D2CBC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241065.1">
        <property type="nucleotide sequence ID" value="XM_016375789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CBC5"/>
    <dbReference type="STRING" id="91928.A0A0D2CBC5"/>
    <dbReference type="GeneID" id="27328510"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01427"/>
    <dbReference type="HOGENOM" id="CLU_004184_11_0_1"/>
    <dbReference type="OrthoDB" id="3557394at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF81">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="80"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="611" mass="69759" checksum="7271509A50A28803" modified="2015-04-29" version="1">MSGLATVRMAANQSVHRSGSTRISDISIPPQGGSTTEFQYEELDPSVDCMRLIELDPGGDADDVPRCKLIHVTFGQKPRYQALSYMWGDVTIKKKISVEGKELLVGQNLWDALRYLRNCGSSRHYWIDAICINQANIFERNRQLRIMPHIYMRAQTVLVWLGRKYAKYRAEDWQVWMDWRVDGKSDMSFSASELVARMEQKQLISTMSLELCSDDYWNRVWIVQEIGMARTIQVCFKECRMTWNTFIHRLTLSCGGNGNGPFILERMLRNKHHRGHTLRELLENHQQAVCKDPRDKIYGFVGLAADARMFPMDYRKPLLEVWKDTMTVMYGHAPFGHDMVLCASLVKNLLGGRHVASKEQVAREYASRTEPPLRIDNKDPRYPTFDLTAYVAGMIICIGPSTAHMMGDLDAVDEWRAQIQQNFPDESVDADHDNDLLVEVLLNAENDDPDLLSLSRLHVCWSAPKVLCEKIQNCRMRSKLEVRSGNFKDEGPRASPMASDIEPQGPKITEALVPASTPRLYQMKRIIPQSSPWKMGIVAGEAQVGDLICWIPRVKKAVAVRINDGWLEIIGTAMAPTKLFWKGTQNRTNYFESDEELELHLDLDSAYVLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y6L2</accession>
    <name>A0A0D1Y6L2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230712.1">
        <property type="nucleotide sequence ID" value="XM_016385768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y6L2"/>
    <dbReference type="STRING" id="91928.A0A0D1Y6L2"/>
    <dbReference type="GeneID" id="27338543"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11460"/>
    <dbReference type="HOGENOM" id="CLU_054813_0_0_1"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="334" mass="38042" checksum="B9288741D7ADB967" modified="2015-04-29" version="1">MSDGLYGVKQASKTKAKEISSSTSLAFSTKLASLISSSSSSKTNSTSGRPRPSKDKSDIFTAHNKNVKKRSAADLEANEQRHKTRDEIGSVDDAELHRSKRKMEDKVRLYNAMKRGEYIGREDYDERGLVDFDRKWAEAQAKGQVSDSEASDSDDAGTDDDEIVEYFDEFGRLRKGTKAQAAREERRKRIQANAAEEEERMSARPSMPTNVIYGDTIQHSAFNPDQDIAERMGEIAKKRDRSATPPPDSHFDATAEIRTKGTGFYAFSQDSDQRKKEMEALEKERKETERIRQEREEKKELRRKEIEERRRVIAEQRAKAQADKFLDSLDIEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7Z3</accession>
    <name>A0A0D1Y7Z3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BolA protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231252.1">
        <property type="nucleotide sequence ID" value="XM_016384650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7Z3"/>
    <dbReference type="STRING" id="91928.A0A0D1Y7Z3"/>
    <dbReference type="GeneID" id="27337418"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10335"/>
    <dbReference type="HOGENOM" id="CLU_109462_4_0_1"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11044" checksum="E495A8E08F492B21" modified="2015-04-29" version="1">MAAPTDTAAAETAATSGVTPESLSEKLKSSIGATYVSIEDMSGGCGQAFNAIVVSPEFEKKTLLARHRLVNNALKAEIAAIHAWTPKCLTPEQWEKEKEKIGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCA7</accession>
    <name>A0A0D1YCA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232727.1">
        <property type="nucleotide sequence ID" value="XM_016384104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCA7"/>
    <dbReference type="STRING" id="91928.A0A0D1YCA7"/>
    <dbReference type="GeneID" id="27336871"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09788"/>
    <dbReference type="HOGENOM" id="CLU_064110_0_0_1"/>
    <dbReference type="OrthoDB" id="5421757at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="365" mass="41456" checksum="BF71BF9A8D7CCA9F" modified="2015-04-29" version="1">MARAAGKRGGKPKATTAPVTQPQTQSTAGPPTPFEYAPASLQPFLSTLPTDHIYLVHLDVTPTSLKKRVFLVPLLLNLLITIGLCIRAYYAAPVYLQQIITIFGYDTDYKVDAKKASAGELVSTIASRTALLMVDYTIFALIGSWPKQFMFGSRWSRYTGPWTWRRTIGFQDTEIIVRCGRMWDTPLLTSEVPEQTKTWVVDEELTIKVKVEPAMRPSYLAKTGSLLLDKDWDLDYKAMVDAHRLDQDGTIQMRDMSNLTMVYYQKRWLIWRVYDQRDITPEEAEQDSVVEKFRRKLAECGAESVFFRWIEIVQFETSQPGGFTPGRQADALRELKRLLAKRGVDYGQFWDDIGGQAGVPGFAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCK7</accession>
    <name>A0A0D1YCK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232877.1">
        <property type="nucleotide sequence ID" value="XM_016384254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCK7"/>
    <dbReference type="STRING" id="91928.A0A0D1YCK7"/>
    <dbReference type="GeneID" id="27337022"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09939"/>
    <dbReference type="HOGENOM" id="CLU_011226_4_3_1"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="113"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26854" checksum="27FEB392476396AE" modified="2015-04-29" version="1">MSNTIVLYDLPSKQGKSWSYNALKARLVLNYKNIPYQTEWTEYPDLKVKLGKTGLAPNETGPAYTSPAIRLPDGSYLQGSRAIAERLEQLYPEPSLHLDLPDQEHVEELVVKFTNIIRPIFTPSVPKILLNPPSQTYFIEAREKRIGMKLDEFAKGAKKCVQTVAPVVKELGEAYEKNEGPFLHGHTLCYADLIFLGLLRMLNNLGEISQFYELEGGDKLKALYEAGKAKGLFDRDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDK2</accession>
    <name>A0A0D1YDK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_08253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233282.1">
        <property type="nucleotide sequence ID" value="XM_016382579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDK2"/>
    <dbReference type="STRING" id="91928.A0A0D1YDK2"/>
    <dbReference type="GeneID" id="27335336"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08253"/>
    <dbReference type="HOGENOM" id="CLU_009967_0_0_1"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000077">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000127">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="610"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW13066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="750" mass="83127" checksum="59B5F493DCDC43DE" modified="2015-04-29" version="1">MPPRDPPFNSKYSHTFSATYLESLRSYRPARPTGSRPPPFTPRTQTVSSESSLTRSDSLPTVNSVQSKAQPDESEPYTIQSPPIPNSSSISSAASLLKGRPLAQPPANDRPILRGRKVSPTAIVQVPQLTEDGVYLESVSRRLEKQEAHNLREALQLIDHKDDENRIYQAAQDEAADLVWKHQNPHAAEVEKTAAYRNPDLKVNGNRRSSGQRKASGTRKVSFPNPESQIYEEPEQQEDRSEKPIKTPSTGLPLRIKSTNTLPWLKKRGMNKPDPAPMADNNRINRVEIHKNPPTRSRDAQYTANTPPRHAAIDTIEEVETPKSSTSTLEIRGEDIRAATSMKRKDRSPNLPTPVAVSDHVGRPIVSFDPSWKPSNDSPRASQDVERPIIKLTERPTPQKSSERPLPTPGQVMPEVTVSAPAVPRINLPDDPPVPLINVCAPGVPTINLPEQNNPVPSINIGEEGTNSSSFPTINLPGEIKQHARPLPKHAATTPTTASSLQKAPSSRLPWLHRHPMPTVSCSSCALPISGRIVTAAGSSSSSVKARFHPECFTCYHCATPLECVSFYPEPDEKRLDRLESMGIEATSPEASNDPLRFYCHLDFHEFFSPRCRSCKTPIEGEVIVAAGAEWHVGHFFCAECGDPFDSSTPFVERDNYAYCVSCHTKRTSARCRRCKQQILDELTVEALGGKYHETCFVCFECGGGFGDEGRFFVRDVDVEPTDKERRKGITRKIEEKAVCGPCEERRLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDL1</accession>
    <name>A0A0D1YDL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233302.1">
        <property type="nucleotide sequence ID" value="XM_016382599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDL1"/>
    <dbReference type="STRING" id="91928.A0A0D1YDL1"/>
    <dbReference type="GeneID" id="27335356"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08273"/>
    <dbReference type="HOGENOM" id="CLU_043314_1_0_1"/>
    <dbReference type="OrthoDB" id="5425848at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF10">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002236878" description="Mid2 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="37347" checksum="57E3306558AA43F6" modified="2015-04-29" version="1">MRVQQIPLSPRALVAGLLLLRPVAASFLPDLLRNFEDLQNVHKRCSNPCGYYGQLCCASDEVCYTDANDQAQCGAGGSGAATTTADGGEWRTYTTTYVQTDLKTVTETFSSYVPASTISCSYSTGETPCGNVCCLSGQYCQSSGVCAAVGGGSSGYYSSLYTVTTIVTNTASAPLRPTSNTLVTVTGAATTTQPFVTPVGTGGSIIYGQSTDSGGGLSGGAIAGIVIGVIVGIIILLLICACWCAKGLIDGLLGIFGLGPRRKRTTEEVYVERHSHRSDRHNGGRTWFGTRPGRTEVVEEKKRRSGIGTAGWVAAGLGTLALWLGLKRRNRRDDKSDVSYDSAYYTDYMYSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDP5</accession>
    <name>A0A0D1YDP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233367.1">
        <property type="nucleotide sequence ID" value="XM_016382664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDP5"/>
    <dbReference type="STRING" id="91928.A0A0D1YDP5"/>
    <dbReference type="GeneID" id="27335421"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08338"/>
    <dbReference type="HOGENOM" id="CLU_1562898_0_0_1"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF11">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="171" mass="17697" checksum="F82AFAFD11E13FEE" modified="2015-04-29" version="1">MEPWGICSDCYAHSGFLDSWNSAKSIVQGAVDGAKQANPSYSIVSTGHSLGGALATLAAADLRNSGHNIALYTYGSPMVGNVALATFITGQGGGNYRVTHANDIVPKLPGYPLGFAHVSPEYWITSATSTTVTANDVQVSSGVVDLQGNQGQLGGTVSDHLWYFNAIAACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YED6</accession>
    <name>A0A0D1YED6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450 oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233657.1">
        <property type="nucleotide sequence ID" value="XM_016382954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YED6"/>
    <dbReference type="STRING" id="91928.A0A0D1YED6"/>
    <dbReference type="GeneID" id="27335712"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08629"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="55375" checksum="36CEF331E278C22D" modified="2015-04-29" version="1">MSLKTYFDYPYSYISAALFLFTITCLLLLNTRRKRGLRDIPGPFAASILPLDRILTTYSGHQFAKHLAYHEQYGPIVRSNFYTLFHAKSPVGSIPTVFSITDPQGHRDLKRPVGAAFALSALLDLETLADECTAILQRKLDGLEGQNIDLGTWLHWYAFDVIMYITFSNSIGFLEREEDVQGIIAAIEGRLFYNSIVGQVPYMHRLLLGNSVVSRLADLVPSLARLNSARSIVNFAAAQLSRRQTAAAEHGKKDIVARFKRTKEGEQVMTDKELLGHASSNVFAGSDTTAISLRALFYYLCKNTRAYNNLVDEILAFDDRGELSEFVTYAEAQRMPYFQACMREALRMHPAVGQLLERIVPAEGATVSGHFLPGGTIVGMNPWVAARDKSVYGVDADIFRPERWLEASEATLKLMDRNWLAFGAGARTCLGKNISLMEMSKLVPQLLRRYHVQLADPAAEWTLHDYWFVKQEGLRCVLTRRTRKDRRKTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YI28</accession>
    <name>A0A0D1YI28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234787.1">
        <property type="nucleotide sequence ID" value="XM_016381685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YI28"/>
    <dbReference type="GeneID" id="27334438"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07355"/>
    <dbReference type="HOGENOM" id="CLU_2133552_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002246998" description="RxLR effector protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12182" checksum="036125FCFA52CE39" modified="2015-04-29" version="1">MRFSVLVIVAPFVATTIAIPITTAAADNGNDHGHNVTLSNDGAPTVVLDHVVLQPDIPVEILTEEFVKDSTAVMVPVEKRGVKGIALFFRAIFCFFGLSFGEKCETKKTAQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIB2</accession>
    <name>A0A0D1YIB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="15">2.7.7.1</ecNumber>
            <ecNumber evidence="15">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PV08_07460</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="15"/>
    <dbReference type="EC" id="2.7.7.18" evidence="15"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234892.1">
        <property type="nucleotide sequence ID" value="XM_016381790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIB2"/>
    <dbReference type="STRING" id="91928.A0A0D1YIB2"/>
    <dbReference type="GeneID" id="27334543"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07460"/>
    <dbReference type="HOGENOM" id="CLU_033366_0_1_1"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000074">
        <property type="entry name" value="Nicotinamide-nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 15" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="18">
        <location>
            <begin position="26"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KIW14676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="270" mass="30391" checksum="951CDF3DFA5A5A51" modified="2015-04-29" version="1">MDEYRFPDSRLKKKMDDSSKTPLLLVACGSFSPITFLHLRMFVMAADYVKHNTEFEMIGGYLSPVSDAYKKQGLAAAEHRVAMCQLAIDKASTWLMVDTWEAEQKEYQPTAKVLDHFDHEINIVRKGIDAGDGTRKPVRIALLAGADLIQTMSTPGVWSEQDLDHILGRYGTFIIERSGTDIDEALASLQNYRDNIYVIQQLIQNDVSSTKIRLFLKRGMSVQYLIPAPVVEYIEQNHLYTDDHRGSSTSLSHPQDNDKGKSKETTASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJF2</accession>
    <name>A0A0D1YJF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3431 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235302.1">
        <property type="nucleotide sequence ID" value="XM_016382200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJF2"/>
    <dbReference type="GeneID" id="27334956"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07873"/>
    <dbReference type="HOGENOM" id="CLU_031559_1_1_1"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW15086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42969" checksum="775C5CD83C8E9FDC" modified="2015-04-29" version="1">MLWRRSTILSLTLGLITLVYLLIGLSSKPKYIYGQNDPLSLYNPSMFTPGTAKPAGHNYSRVLVMGHLETEDVSWVSRDIPGLRTKFYRVDSNSSRSDSGLPANKGHEAMVYLTYIIDHYDSLPDVVLFFHPHRTAWHNNILLDVDSAKTIKLLSSAHVVRQGYFNTRCHLDPGCPDWLHVDRPRWRHDLKHKPEEPALTSALFHELHGADVRVPAAISQPCCAQFAVSRERIRQRPRADYLRYRAWLLSTDLDDDTSGRLMEYSWQYIFTGNFEFCPSQHKCYCDGYGICFDGESGLQHWLAVLRERERLEEKLTSLWDSGVTAGEKYKGLVAKIKQKTQLLDRLREDALRRGFDPALRAAECGREWHEGDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKA0</accession>
    <name>A0A0D1YKA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235622.1">
        <property type="nucleotide sequence ID" value="XM_016379795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKA0"/>
    <dbReference type="GeneID" id="27332535"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05452"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="12"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW15406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="499" mass="54803" checksum="4A990205C60FF09A" modified="2015-04-29" version="1">MALSASVIRFFIVLFVALGSLTYGYCSSIIATTLGQPTFISYFDLDTRSNATQLIGAINGLYQAGGLFGSLSMIKFPDWIGRRKSLLLYSIITVVGGALQAGSVHIGMFLVMRLITGFGIGALVGLVPLYQSEMSPPRIRGLLVGMHGVLICVGYTLASWVGLGFYFVNASGAQWRLPLAIQCLPPLFLAIGVLFLPESPRWLIDRDRVEDAYQAFKAVRAETRDNIVNNEEAIQEEFKLLQGQILHERQEALSMMDLWRLPHMRKRCIMGFLVLFGCQGTGTLVINNYGPSLYSSLGFDTVQQLLIQGGWITVCPFGNLLNSLMVDRVGRTNMLVWGYAGCVVALIGECITVDLFNKSGDRGLASAAVFFLFLHIAFFSATCDATSYIYASEIFPTPVRAKGLAVSISGLFVATIIFLQVAPTAFAAVGWRYYIVFIAVTTVIGTAIFFWFPETKGRSLEDIGELFGDSVEPLHLDEKVRAQHASTEIVNQIQAEEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKR6</accession>
    <name>A0A0D1YKR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_05639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235807.1">
        <property type="nucleotide sequence ID" value="XM_016379980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKR6"/>
    <dbReference type="GeneID" id="27332722"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05639"/>
    <dbReference type="HOGENOM" id="CLU_120071_0_0_1"/>
    <dbReference type="OrthoDB" id="4142992at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW15591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="135" mass="14571" checksum="64FD713245BCFDBE" modified="2015-04-29" version="1">MCTAELIKSRTCHHKWVTIVKECNKGAGFEAGHLHRFEPARPGLFRSRYISAAAHTCPECDKKADYNPSTTRIIVNNAKDRGTLGNGYTLTDGYGNPLPGHYSGGGYGGQGYTSCGMARMSKRPSADHGCGCNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YP34</accession>
    <name>A0A0D1YP34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_04106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237132.1">
        <property type="nucleotide sequence ID" value="XM_016378455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YP34"/>
    <dbReference type="STRING" id="91928.A0A0D1YP34"/>
    <dbReference type="GeneID" id="27331189"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04106"/>
    <dbReference type="HOGENOM" id="CLU_004835_0_0_1"/>
    <dbReference type="OrthoDB" id="5244761at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="571"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="931"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="291"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="939"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1089" mass="120324" checksum="F26157D0C73402E1" modified="2015-04-29" version="1">MDDISDVDVKHERSNPYPPSLPLPPPPPPPGAVHRMPPAETPPLHSYHQSQAAAMPPPAPAWNPAPSPYTNSEPSEHRPPPPDLGHQQPYPPPSQSYPPPPPPPPPPGRETPSYPPDPGYGRPGSVSGPTRSPAELNRPPYHPVSAPHEPPYYQPPQDYRAPHHAYSGPENQPNGTHQPLHVVTGHDMMPSQPPGPPGPYGPPSAGPPATPGPYVQPPYYDPNYQQRRKPVRAAQACDSCRQRKAKCDEGRPECQHCKDNGLKCTYREVPPQKSEKQILNITDKLETMSGNIEMLIQNQKAQAELQQAQAEKINQLLNTLQQKQQSEVVAAPTPDEQLDAGLRQQQQSTVTHNPPDPAYPFRRGESSDAQSTRRPQVQPKTSTVQTGEGERENFELTLPLKHTTAAQNLLNWPSIKKLIPPRITASYVIDEETGRGLLRLYGSGEGEDKNDGHEGAPSPAGSTSSDGRRIDEETSSSPHGVWGTGQIHAPTPSSIPNNPHAVRDHPGGVSPHGGLMLDSDAVDRYFRSYMDHMHILHPFLEPRVIRHMIHTFKRKYSWDVRSTPHTAATIGTKRKREMTESPTPMEEHTSNHINSRPQGRPLSTGVPLIEHSVANAIVLLVIALGKVCSYREPLPGPATTTSMRTSTPHGALYSDLPMPMSAPTSPFNAQSNLNGTNVMSISSPANPQGKNMDAIPGLAYFAKAADILGELPGGTDVSYIQANLLAGLYMGQLARIIPSYEYIMKACMAAQILIESRPYKERTIKPNRRNLINFAFWSCLQLESDIAAEMDLPLSGITRFESSQHKDMPTSVTLEHGLDGTSNADDIVRFYLYQIQLRMTMNSVHSTLYRQSKDPSTRPSITIMGVLDENLENWRTILSNWQWSDDDHESPDINTARMRGKYYGGKYIVWRPAVHYALLISEGLLKDHSDESPAGYGNSELTSPSASYTSVGDHQPPRQPSEMPYISPDLLRAAKMCIQAAIRSTTCFDKVPRRLIVTNIFGTVHAQFGNMLVLYATYTARHPGLNSLIDEYTLKRLHDRTIRILRENEAISPVLAKDRQILEHVRTKVFGPPTSYPGVSTSSSFSSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPU8</accession>
    <name>A0A0D1YPU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PV08_04442</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237467.1">
        <property type="nucleotide sequence ID" value="XM_016378790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPU8"/>
    <dbReference type="STRING" id="91928.A0A0D1YPU8"/>
    <dbReference type="GeneID" id="27331525"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04442"/>
    <dbReference type="HOGENOM" id="CLU_000846_3_1_1"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000067">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQT7</accession>
    <name>A0A0D1YQT7_9EURO</name>
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        <recommendedName>
            <fullName evidence="3">Spc7 kinetochore protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016379105.1"/>
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    <dbReference type="OrthoDB" id="5592879at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Knl1_RWD_C"/>
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        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
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        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
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        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="929"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1632"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1675"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1690"/>
            <end position="1699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1727" mass="189174" checksum="432DA82718CC9D2B" modified="2015-04-29" version="1">MADSSTDRKSHKPKSRQSIAHIPSSRSSASRDNVTTDIAAIHARNNAAQAAKKRSRGKSLGPGGLEALTETTGNLTKTPVPFQIKSILKPSIPLTPPKAIPSFDELRKRSTGKGKSPAKNGAEELLIDFSTPGPNMQNRGGISLEGSENVADPFSPMTRQSPGKSKAASAEAQEREREEEAKRQAEKQAILDRRAARRKSLANRRVSFAPEATLHTWSVMELAEDSTTSSASNSTRRQSSMTAQQSPVKVMPSRDSSASPSTPVEQLENPMETPSPAHQRDLHQQKRRRRSSSTAREPMLDESQYEVFSSSPSGDVTTNSSPMHVEDGIESSDDSDTDGDTAMSMDDETSHTVNSQDSGSSTHSSLEGRLRQAAAQAGTAGVDYDEHDEEDMSMEMATGTVTHAFQPYARKQVSEIKNSVNQENGNFVGESSRHDAGREDSSFQVDDDAQSQSEDMSMDVTRAVGGIIPRQSPGKTNQKSPKSRRRSIHPRRSMGNESSFDETIEFTVMQGGIIGESDKSDASMTQTRSFDEMTMEFTIAVGGVLSNADRRQSDMSEEFEENQTMDMTAAVGGILMPIEEHTEPQTDAEDEQTVAMEETRAVGSIINQHSPAKRRVTRQSVGNASTSPRTLPSERSTAKTTPQATPRSNTKTTPKTTPKSQLHRTSVASETGSPSLVAKPQSSSRSQRSSSKASTTPQAPPPSTPIMSHRRPQAGTPSQQITPLPEHAPSPNKTPLSANVQHRGASPKKLFKAEIKARASPASTRREATLKTNSLFSRDAETGQQTPSIILRASRPQLQRRRSSGIGIDKAGIGSPRISEILDRRASIGDTSAEFKLGAIKPTKLRFEDAEQLGQEVELERQEEHRRESGRFVMEREADEAQEEQTTSQLKEMIETMSPQKLKASKIKGRKSLAVGGAKGLLGKRPAELDIDDDEEAESTPKRLKAVSREGSPVKKVHLPKPPSKDETTGKLSLKLQKSLAEMAGTVRSTPTVDAFQLVRETVPASPEAGTRFRDVVATGNDRPTSFGDKLDNVVGAIDVSTAQLEEGSTSAEQEKISLQDFLNMTNIHFIELSTTKRRHTLAQSMPQRESQEGTTAPSTEMNFVAAATTLPLLELYQHATRELKSYISTGRKIIRSIEAETLAEQPPLFREYLDARPDVKVIMDNQFRNGKANARLQSKEGWYQWRGQLVDGLKAGLQGIKKGMAADLEVLQQQQRALDDVVPQALQEQSQLETQANSLRQSLEEIDSIDHEALEDFRQQLRHVDEQFLQKSAHLEDLQQQMEEKNDALIAAADYKAELQDQIAESERVREENRGVPVAEVLALKSRVETVEKKTGWRLLTAEEDVDEPNEFGPALVMVYKDELRLFFHPQAFQFKPEQSGRRRSGRKSASTSGPSAPISLTYAPDQDDSQAGPPSLSTEKRFFLQLIRSQLHAFAMMPKGTITAKTLLSTVSNGWSLACRVSEELRLLGLVGVTTVSIMGDEKLGVKVMLLLPFRGRVDIEFAVTVTILNDGEIVATSVVTATAVYGGAVNTLAGKNRKVQNALGKEVESRPLGDGAWVSAIHGFKAWVSAQEKAKEEKTSKKVEEVASVPVVPAPVSTHEASAQVVSPSTTQQRRQQQEPHHPPPPSASSPLRRSPLAPKRTNAIQKKTLPVSKQRIEKFNLSRVNVEKENFNPSLSTSSKGNAAHDGNDWDKEISRPAIPPEMQEAMMHTPIKRVGALRRSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRP3</accession>
    <name>A0A0D1YRP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238127.1">
        <property type="nucleotide sequence ID" value="XM_016379450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRP3"/>
    <dbReference type="STRING" id="91928.A0A0D1YRP3"/>
    <dbReference type="GeneID" id="27332189"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05106"/>
    <dbReference type="HOGENOM" id="CLU_010170_0_0_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="680" mass="74760" checksum="943966AC83B62831" modified="2015-04-29" version="1">MAPSTASSTRRRCNNACGNCKRRKERCDGVKPCQRCRARGVKHECHFSAPVLRRVVLDSGAEAYEAPDRDTWNKDRLSLILGRSSDKAPATANAPNLKQHKPQITPLPRPWKRSEGGFIYFGGSSASSLLQNVRHLAKIAVGDCPFVSSSYNLSAGPPVDERLPSTIRGRLVAPSKPDIVRAKSLAKWYLYSTACFGALFDESFLIYELSAWLSHPDGKQDGVTSRLFLILALGAQTCPEENDIVAQEYYTYGRALTVLDTIGDSSAVLETAQCYTLITMYLINASRLNAAFIHLGQAVRAAHSLGLHRTDLGADFTPFERNARETLWKAIRVLDVYLSATLGRPLATCESRQTDMTTNYSPTVDMCMIYESLLTEVYAKSSTCDEILQQIIDRNRQWAARFPSGLQNDGVCASEQIESGDHFLPNVGLFHIKQAFYGVTILLTQSHLAGIVSASTQSPDHRRVYPGSQSSQMLGLACVQSAIDSIELFRSLLVADQAPKHLPLVTNSIFYAVLVLGMATFSDLYATLPIDEHLGTACKLLSVFDKHDWLSRQYLGISEDLSAACKTYTEKKLQNELNTRRALVSEIFGAVGSNQDVGLGQANLEPGMFEKKCPSVSIREEVGQNPSPAATLPDQVGTSMDLVIGSLTIDPLEFSDFLEDPFLIDTQDHFVLPISSLPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YS29</accession>
    <name>A0A0D1YS29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238222.1">
        <property type="nucleotide sequence ID" value="XM_016376652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YS29"/>
    <dbReference type="STRING" id="91928.A0A0D1YS29"/>
    <dbReference type="GeneID" id="27329376"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02293"/>
    <dbReference type="HOGENOM" id="CLU_039765_0_1_1"/>
    <dbReference type="OrthoDB" id="4388755at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002237297" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="76"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="385" mass="43557" checksum="1DD38D8565C434A9" modified="2015-04-29" version="1">MVLSRGFVTVALVVYTVLSKFANSVTAKSLHDNSPKCDCYVTNGRSSAFFQYHRFFDFGDVSTDSVYDSEPANVTDSQSSGDEPSQQGYIRSHAFSKDWSIQTWGRKSTPPVYPVTMQMSPQNVFIQRNPEELPSTHLTLRAYRSRNFYSTAEIQYQQRNLLHASIRLRARIRGASGSVAGIFVYLNDTQESDIEILTNDPSNHIRLTNHPVFDSDGVYVPNAMSDVELPAPTVWTDWVTYRLDWTPTKSSWYANGQWLFEKEYGVPRFPSVLIINMWGNGGTWAGNMTLGSAAYLDIRWIDVVFNTSGPVTGYTPDETKRKFRRDTGLLEKREDDDNCHRVCAVDDIPAVGFPVLVSDATRTTWYSQRTLEYILAITLAVVVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUZ6</accession>
    <name>A0A0D1YUZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239312.1">
        <property type="nucleotide sequence ID" value="XM_016377742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUZ6"/>
    <dbReference type="GeneID" id="27330471"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03388"/>
    <dbReference type="HOGENOM" id="CLU_1061866_0_0_1"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="262" mass="28801" checksum="691B6147F6F830F2" modified="2015-04-29" version="1">MDKATSTPGAPERHVLLIGINAYQDKPLEGCVRDCWAMRAYLESLPVPLNLRMLTASRSSGTPRPIEDPRYWPTYDNVKAWLEDIASRAKPGTLVYIHYSGHGVRIRPSTAIFSLQDGDVALALLAGDDGDRVRYLRGLELAHQIKALVAKGSLVTLVLDCCFSGGFSRIDDTDSIRSLLYDADIDASYPFNPAAEIAADASHSASRDVSMLPNWVINPEGYTVLAACGPHQVAREIEFESGQRNGALYRATLTQWELNGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YV79</accession>
    <name>A0A0D1YV79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_03490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239412.1">
        <property type="nucleotide sequence ID" value="XM_016377842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YV79"/>
    <dbReference type="GeneID" id="27330573"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03490"/>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW19196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="65739" checksum="67D849D2F2D84BEC" modified="2015-04-29" version="1">MAARNLDAQQDASSHPIGEHRPIRVVCIGAGYSGLMMSIIVEQKMKNHNVSFQVYEMNEDLGGTWLVNRYPGCQCDIPAHNYAFSFAPNPSWPNYYATSEQIYDYMKNTSAKYGCDKYFAYRHKVTGATWSEQSGKWILTVEADGIEFTDTCDVLINAGGVLNNWQWPKIPGIHNFKGKLLHSANWDTSYDWTGKNVAVIGIGSSGIQILPKVAPGMSHVDFFVRSSTWISPAPGINEPTPEDPDVDEHYNYASYELERFRTEPEYLQRHRRFLADKRIANFKRSMAGSKAQNETDQLFRKTMIDRLGSSEKGKRIAEWLLPDFPVGCRRLTPGPGFLEALTMENVNSHWDNIDSITQTGIQLKDGSHKELDAIFCATGFDTTFRPRFPLKGKNGLDLAEKWLTDPPEAYFSTTVPDMPNYFMFIGPNSPISNGSLVQAIQMTGVYIYKCINKLQTQSLKSMTVNAAATKDYNEYSQNWLSKTVWVAPCRSWYKRGTTDGRVVGVYAGSCFHFAEALRDPRWEDYDLEYLPDGHLGMNRFSWLGNGFTKREMVGKSIGDTQTLTFDEYWDLMVLPEIHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZL9</accession>
    <name>A0A0D1YZL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240982.1">
        <property type="nucleotide sequence ID" value="XM_016375706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZL9"/>
    <dbReference type="GeneID" id="27328427"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01344"/>
    <dbReference type="HOGENOM" id="CLU_084512_1_0_1"/>
    <dbReference type="OrthoDB" id="2121879at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252326" description="DUF7707 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="3">
        <location>
            <begin position="45"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="221" mass="22052" checksum="D1A9B465BA8AB4CB" modified="2015-04-29" version="1">MSRALLVASAIAAVAHAQTLETSSASSVAATSTASQVMPPVATQAFNPAGINTTVSFNWCHAQLNTCPLICGGSASLNQCDDVAFTYSCVCANGTVPDSTAFIQTLPFFICQETYIQCINNNPNDAQAQSVCKDNEQCGTRNATAEYLAEQAAASSAAASTTAAASSAAPSSTPSTSENSSATATSSSAGASGSDNAAAGMAHVTTGAFAAVLLAAFKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZA04</accession>
    <name>A0A0D1ZA04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydantoinase/oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_11958</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230073.1">
        <property type="nucleotide sequence ID" value="XM_016386265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZA04"/>
    <dbReference type="STRING" id="91928.A0A0D1ZA04"/>
    <dbReference type="GeneID" id="27339041"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11958"/>
    <dbReference type="HOGENOM" id="CLU_007154_0_0_1"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="201"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="3">
        <location>
            <begin position="589"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="4">
        <location>
            <begin position="749"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW09857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="971" mass="103858" checksum="E10F6D4CBEA8A432" modified="2015-04-29" version="1">MPSKTPSYVIGIDVGGTNTDAVILQNEQVVAWHKTPTTSDIQAGVELAIREVVRKGDIDSGQIESVKIGTTQFINAVLEQDRSKLDKVAVIRLCGPYSQRSPPFVHFPEGLRTLMEGHCGYVDGGYQVDGRIVRALRHEQLKEQAAIIKSTRIKSVVVIGINSPSNPKQELEAESVLISELGPGYDVSCSHKIGRLGFLERENASILNASLRRFARHVIAGFKFAVQRLGKCSLYITLNDGTLSKASEAAEYPIGCFSSGPTNSARGAALLAGSLSQDEADDREVLVVDVGGTTTDICALLKTGFPRQSAAFVKVAGVRTNFTIPDVHSIALGGGSLVRTERDQTRIGPDSIGSRLVRDGIYFGGQILTATDLILSNDLTERLVPSHIKASGLVEIKRAVEEAVDLVKTKQGDARVILVGGGSIIISDEIAGVGELIRPKHFEVANAVGAAIGKISGSVDTIVAPKADNASMDEQIEEAKALAMERCVAAGGSRATLEVVEIELIPVSYATNGATRLIVRVVADLAEGHEDPEESVLPMLYDFGKSIDSECRADGADSKASSYDINQNLDVESYRPRIEGDLWYLSEIDLQFLQDGTGVLGVGSCGDAYPSYVACVHALAKGEDITIRRQDTLPDSASVLAAGFMGSPTVYLERIPGMHEVIDAMNAVIETADITSFDAVIPNEIGGMNAFEALLAASHFGKSTLDADCVARAYPFLWQTVRCLRGVSVVPAAVADGAGRRKVFTAEHDNFQAEELMRDACTDLGSLAGICINPLQGSEARSLPRNSYSLAWSIGRSIALSRSRKIDPVAALLKEHHGVLLFRGKIVSVVRHVAKGFTRGSVLLSAFSDESIPQSDGDNYSPGSSLQVEFENENLCAVLKQEGQEDKLLAICPDLICFLDMANGAPLGISDYKYGLRVSVVALSAPPVWTSEKGLRMGGPSAFGLDMEYTPVGTEAYEPPTSVWDMFGKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAU7</accession>
    <name>A0A0D1ZAU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230353.1">
        <property type="nucleotide sequence ID" value="XM_016385409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAU7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAU7"/>
    <dbReference type="GeneID" id="27338181"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11098"/>
    <dbReference type="HOGENOM" id="CLU_272250_0_0_1"/>
    <dbReference type="OrthoDB" id="10422723at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1187" mass="133009" checksum="C10EB5F307A7D29F" modified="2015-04-29" version="1">MLPALISSIRNNDLGSPNKHRPSDSSRLDATIILPWSNALRSLPSIKTIFDTSEDVIKVVKKLSRASPLRHLKFTVVNQTSGATKTIESIALSMRSQRYSYHLGRFMIPAKHGHRLGMHLRCLAESAASPPSNLTSAQHLWLLRGALSLLAADVNKSSNSGSESLVSLPSPHIYRQENGQLTCRVPLWGHGKATETSRAGQDLWDAHWELDVATILRCRPVQPLYTAYVKWTQLDDQQSADTQLNDKDLLHVHNVAKQAALIGGCWIGWPEQCIAAASEACTASRTVSLRNSPLCNFQKVFERGVVLLEPGAWLRNRAEVKFSDIRLNGPTTEEIFWVIDAILQGLNHGLSIHDAWLEGAAMSVTLREMYLEGRGIWPVTSCDHPVYANALHVCPGCWVLRVCSDFVESPNHPNPICKKCDSNGPQLNLTMPLDLTPYLRWRATVTFRNESKTHKLGWNQAEIKAKVDTLMVNLQPFFVDDTRDTIRDAFIDMDLKQDIRPVHLTEDGMRRHPLTPSIDAFTAVYPGADGRTAYHHEANIVPTSDAINHLMGVYEKPLLRAFSAMVLATEDTPSDRRLYERALQFWRDCHKNSYEMGSFLSRLLSHRINKPVPANMPAIMEALRTGKPLLPRTTSLSTVYRVTIEGQKVYLPAGWKFPDYSYIMDSIHSAAREHGLDSPELRVLWLRNGTFCPFALDCVLPEDYNDGTIWNIFYVRFDRMRKDCDWREVGNPHRERAEIGELMIAVAHLWFRNIKRDLQLGIPVDRCGRDELGLIPHATIRSLLSASVGHRHHAKPMTLGISNWDPAGGTACSFDYDKCNICWETCACNWIKFCWNEKYYPLIFNLLPNVRKEPLPGIDPKFHLVELPDQPLQTEFLPCLVPVEMTEDDAEEYSVPTDTEPASVTVHEDKPSKVERSKLGKHIELLEDVNVENPGFVTGYVDLRDYALDERDQQRIIADIEAAPVAQSLDVQAFEALTEDAIARIDPESPGRSGFSLVLDLLRKYYGSDRSATFADLANRLLQHIGMHQAFDVAISSRDELMDTITSAMSSAEGAETTIPLTPRRSKGHPAPEAELPSRIPKDVGSAKRVVVKDEAYSGSPTKSGRKKTLLSSPRAVSRLGMHGFAQPASPRIPSLAPRLLFPPASHAPGGQNSPRQYSHEGNDEDESRRGQQQQQGDEPTDNRDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZB31</accession>
    <name>A0A0D1ZB31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11188</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230443.1">
        <property type="nucleotide sequence ID" value="XM_016385499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZB31"/>
    <dbReference type="STRING" id="91928.A0A0D1ZB31"/>
    <dbReference type="GeneID" id="27338271"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11188"/>
    <dbReference type="HOGENOM" id="CLU_011455_2_0_1"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="136"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="608"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="663"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW10227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="782" mass="86263" checksum="62B43D321C2E3A45" modified="2015-04-29" version="1">MSVRGVERPSLTWQRRTEALYQENVNLKQQLGASRSPPESVIDQNAREDTLEPAANPLSNPAMSTSNSVLNNGGSDSASLLPRPLTAEADVNFPPSWNQPFAQASTRQSPNPTATVSRSLAGMTVEADEIDEIFRLYFAHYHSHLPFLDPNISPNSYYDQSSLIFWAIIGVGVRRYTANPTLFGSLAEPILHLPWPPLHPTPAVIPAIQGLLLLSSFPFPTDSTSKDTSYTLSGMAINLALQIGLHVPTFSQDYSRSKMTLTQQDIQRRLQLWFHCIVVHQKAACGLGYPIMVSPDQLQRSMDPRGLTDSMTPLLLLEMRLASLLSRINTLFSPSMFRVEDAQDKHSRFAREMMSDTFENQLDELESERKLSELEKLYINITRLQIRVHCLQDRENPATSVKVTQLGLCATSIIESIERLEVEMSLIQHCPHYIFRIAALAASVLLRLSKQSRPPPPTSTSRKTSIGGVNGISGGSDDYNNNDSANRQQYARQQYKTYFFQTISLLRKMSVESNDMPSRMAKIFSQLWSIDKIFEQTNTVNAAAAAAATTSSSTGAVVVDGVSPGDESGSSSASSLSAASPLIVQSRLSMSVLHDAMWRWKDRFKWAGQKQHQNQNQNRHHHDSNQHQHYHQQQQHHHQGRQSSRGMAIAQENHAHHDRRSSMAATPSMTTNNTSANANMAASPPTSENQFPRPLSTIPPASSSSVTGGYVGTPAYNFPAVNMTPDVGTDGSLNGGGGGGGSGGMMMSFVDGFSPLGSLPWESATNQDFEMMIHRFPESWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZEF3</accession>
    <name>A0A0D1ZEF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_10672</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231588.1">
        <property type="nucleotide sequence ID" value="XM_016384986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZEF3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZEF3"/>
    <dbReference type="GeneID" id="27337755"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10672"/>
    <dbReference type="HOGENOM" id="CLU_013294_0_1_1"/>
    <dbReference type="OrthoDB" id="5561659at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="421"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="673"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW11372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="697" mass="78650" checksum="FA56F6614719E0A1" modified="2015-04-29" version="1">MSTFNGIVREFPTIRIDYFRPHLDQPPPEALFLSHVHSDHLLGLESVKMPFVYCSATTKQILLRLEKYPSRINFAKGILEARKLHYRHLKTVLRTLPLNTAVQIQLNPKRTINVTLLDANHCPGAVMFLVEGDGKAILYTGDVRAETWWVNSIVQNPFVLPYVCGLKTLDCIYLDTTFASHDEPYKDFPTKAEGLKELLEKVSQCHPDTIFYFRAWTLGYENVWIALSNFLQTRVHVDKYQLRILRPVEDHGFNPYPEGAALTGSTVGNQQVSGCLTTDTHVKIHSCEPGLPCHAELSRLNNVKWITPIISRLKDGTEILELGAGGGGGDLYQSSELSLGDSASLEQLGALCLQLTDDEQVKAKITAEVERGKRLRDFHIHIRGLPLPDSHDTPTVALKDLVAKLAKCDSWSDPSGLIKEHVGTHNKNNTIHFPYSRHSSYHELRHLVRVFRPHDICACTVDPETWTDEVSMEALFGDLCSSKYFFFDKMVRNAVEEKKIVAPSYSGKRKRDWIAEAQSQETQASHELDHEDAFETAQAEADIEQKQNLVLHNTGSTATDLLNDTLDKIRAAFLQINQGRTRIDLEDDRIDSLATSDFESQTGSSSKLPRKQNEGIVLQVLPEASTHQDNVLPTELETSTQGVFGDDQLENDQRSRARMEAYMAAKRCLQDNDSSEWDDLPLRSVGRQGHQEKEFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZGQ7</accession>
    <name>A0A0D1ZGQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase CHIP</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RING-type E3 ubiquitin transferase CHIP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_09422</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232363.1">
        <property type="nucleotide sequence ID" value="XM_016383740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZGQ7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZGQ7"/>
    <dbReference type="GeneID" id="27336505"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09422"/>
    <dbReference type="HOGENOM" id="CLU_056455_1_1_1"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16654">
        <property type="entry name" value="RING-Ubox_CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045202">
        <property type="entry name" value="CHIP_RING-Ubox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="211"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="138"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW12147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="287" mass="32805" checksum="C2E4CE63F1842E8E" modified="2015-04-29" version="1">MTNLSFREQGNERFKAGEYKEAEELYSAAIAEHSRSDPKVFANRALTRLKLQDWQGAESDARKAIELYGPKHEAQAMKSHYYLAQALLPQRHVGEALTEAKHAYATCLETKDSSAELIGQFILKAKQAQWQAKETARLRELNSTLALVEDLLNQQLERDKQEVQARFENQEIGETGRQEEIDELEKEAEARRANIRKAFENSASPETVERVVPDWMIDPITFEVMHDPVVTPTGVSYERTSLHRHIKAHGCDPLTRQPLKYDMLIPNVALKNACSEFLDKNGWAVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIU7</accession>
    <name>A0A0D1ZIU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233003.1">
        <property type="nucleotide sequence ID" value="XM_016382300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIU7"/>
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    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="19"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="375" mass="40409" checksum="7ECCC55E4F99EB1F" modified="2015-04-29" version="1">MALKHLPRSMKAYLLEEFGQPYRLREVPVPKIEHPDDILIRVEAGSYCHTDAVLAAGAMHPPSLPHIGCHEFAGTVVLLATGKESSHGLRVGDRVAVSGRGYHVCERCLECQHPSGPDPDEPGFSVYCPYTHGGLGVHGPGGFQEYAIVDSKQVTLIPGTMAAVQVAPLMCAGLTVYAALRKCNLQPGQRVGIIGCGGGLGHLGLQFAAKMGFKTTGADVSPKALDLARGLETGIQIIDALTETPEDIRRSMGKEDNREHISEMGLDAVLILPESQKSFDYGVNLLRNGGLAVVVSFPPEGFHVSAADLVFRRISVTGTLIGSNRALKEMLEFCVEHKVQAKIKTYPFSAVNELVEDYHAGIPGKLVVDMLQKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJY5</accession>
    <name>A0A0D1ZJY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233348.1">
        <property type="nucleotide sequence ID" value="XM_016382645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZJY5"/>
    <dbReference type="GeneID" id="27335402"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08319"/>
    <dbReference type="HOGENOM" id="CLU_043418_0_1_1"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41417" checksum="99C4A59A93D35E44" modified="2015-04-29" version="1">MALPVVRSLAECAVYNNTVAPYVFQLHSLPEVFVQSWTNVPALKQLYLDTNPLVSAVAFSVAISPVFLVVSELNKNYSQVDRVWSILPTFYNLHYALYASLAGLDATRIGLVAGISTIWSMRLTYNYYRKGGYAIGSEDYRWAIVKRQVGPELFFLFNIVFISLGQSLLLTSITTPSYVLLLASRYATYNSQASGFGLEDFVASSIMLSAILVSFVADQQQWNFQTSKSNYRTNAKIPPGYTQEELDRGFLTKGLFAYSRHPNFAAEQTVWVGLYVWSCLVTRTWYNWTGIGALSYLSLFQASTWLTELLSAQRYPEYKIYQQRVGKFLPFSTTPGWASQKKKTKNIGNGQAKDSEVAQASRRYALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPW6</accession>
    <name>A0A0D1ZPW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235078.1">
        <property type="nucleotide sequence ID" value="XM_016381976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPW6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZPW6"/>
    <dbReference type="GeneID" id="27334730"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07647"/>
    <dbReference type="HOGENOM" id="CLU_012287_1_0_1"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="337"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="773" mass="83968" checksum="6F1DA26B079F4221" modified="2015-04-29" version="1">MPYTPPTHQSPASSNQSSPTPSRSHSYIKGQFLSPDLPATSGRPNLPRSSGSSTYLTKHRRSPSLNDAHNDVLYNGESYEENGILDPYGSIRQSPPPASNSLIPAGMTISPPDSSHNSSDDEESESRGRPRDLELGNLEALQAAIRSLEQRKTGSPTRQKNDKPETTDPQVDDRGASDNSAVRRPPLSQEARKISHSRSSTDSNIVFEPVKPSTPPSISQPESDDSDSDSRSTHRPPMVRKKSGELVRPALRPSSRRRPSSMPGTPTYSKAVHFDSHLEHVRHFLQVDRPLAVSAGSSPVETYESESEFPFGSDEASARPRANAYEWDLRLRNFDENNPARKSQVVFVERIFLSSDNKSLIGTVAVQNLSFHKQVVARFTFDYWKTTSEVVADFNHDVRRKPTSDGLDRFNFSIRLIDQANLENRTLFFCVRYTVNGQDFWDNNFSLNYQVDFVKKSKVQQHSLPTLGARPITALPRTRQSPPTSSGRTNRLPSSFDDFTNGFDSFGYQSASALMGEPKLKLRSPRSKGDLVSDAPSRRKASNGQAFGNRYDFNSSLSAAKSSALAALGEFSGLTTSRADTKRSSSHEVPASTHMKSVAIAPPKHDTGVNGSINGASSNAPAVAPMTSKPAALVTEKPTLTSESYQDLAMKELVEKKFCFFGTAGTSKHGEPLKAAALRLVDGAADSASASDLSADGSSRSANSSGSSTPTPPRSSSPALSANSNGTYFGRPPSQGPFYGSRSQSPVSFGYPYHSSSQHTLMSETPTPTAIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZR80</accession>
    <name>A0A0D1ZR80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235533.1">
        <property type="nucleotide sequence ID" value="XM_016379706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZR80"/>
    <dbReference type="GeneID" id="27332445"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05362"/>
    <dbReference type="HOGENOM" id="CLU_022766_0_0_1"/>
    <dbReference type="OrthoDB" id="3469225at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="639" mass="71201" checksum="13EE949E51537CBC" modified="2015-04-29" version="1">MSPANDQHDALTLLNPPAVPSLLDLHEPPTSAHLPINAGMNISGSSTIPAKTRGLLEQRRNPPTSRELAVSTDRTQGGSFVDLQIIRVHSPCHHISVQDRSRIKAHAMRQVHERRRTSKKGPLWALAGQATQRSTELQIQRPKTHADTNGNPSSQGTGAPLAISSPFERTSQGVTLVCVHCGLSRFPRNHDSDYFDIEYDGLPNAPLAESFDVFATTLAPITHRVHELLNHYLEIVAPVLNPPLYGTTNKSVAAFTLIDILRGMVNDEGCMHAIVADAAWEISARRLKNNELEEAARSQREAGFHFFEAVKFLQRRLENSKEALSCSTIVTSCHLAGVAVGYTLGAFAYQDVDGERIPQTKGGKEQFAAHHNGIIRMVQMRGGIDTLPRQAAYHVSKGDGLMAWMRNKPPFLPLFRSRFYRGGKLTAEAKTMIQTFRKSTVDDHLQEFLGEHLAGVEDCLQNLTQLVELNSHSPRRVTSAMREFGEDTYAKVQHNIVSFSISPRDVNVSPHGHRQDAWRVAALIYLNSAIRRAPSKYLLQSMTARLVAALQSSDMATLWGSHRTVLFWVLFIGYLGSNGQTEQIWFAVKIHQVVQAEGFQTLGEMRTVLRRFLYRDNMYDRLLKDLCGAHLDMPLPSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZV76</accession>
    <name>A0A0D1ZV76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RING-box protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_03815</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236843.1">
        <property type="nucleotide sequence ID" value="XM_016378166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZV76"/>
    <dbReference type="STRING" id="91928.A0A0D1ZV76"/>
    <dbReference type="GeneID" id="27330898"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03815"/>
    <dbReference type="HOGENOM" id="CLU_115512_2_1_1"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="59"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW16627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="125" mass="14089" checksum="98B4A7C19D207ED6" modified="2015-04-29" version="1">MADVEMPDAANNASEEPKGKATVKASKSAAADGDSKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQGAATTEECTVAWGICNHAFHFHCISRWLKTRQVCPLDNRDWEFQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZXS5</accession>
    <name>A0A0D1ZXS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237663.1">
        <property type="nucleotide sequence ID" value="XM_016378986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZXS5"/>
    <dbReference type="GeneID" id="27331724"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04641"/>
    <dbReference type="HOGENOM" id="CLU_486629_0_0_1"/>
    <dbReference type="OrthoDB" id="10640387at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="560" mass="62787" checksum="0C2CC4D9B8A63DEC" modified="2015-04-29" version="1">MERNTIPASPEGLGKSRRTLPPLARIRFNKEEALKNPEQKSPDEFSKPPTQLSHYERLRLPGGPGSGTPLLPTPNALDTWASLQRHTENCMKFLTPEMSSTPGRERKSFQPRLQAPPGSEDGSEVDPQNPYPPKGNALVRNPFTGKLERREGLETRYQSQKEAWEKKQREKMQELEARAPTERETPNLADNDKDTNGNTTEAGNANVLEHTTGIQKKEDDSPSHDAPNDADLKPVMTTEHVGNPNVQIQVHGDGDVPKAGNANVLEQIAGLQEKEDDSSSHDEANNADLKPIMTTERIGYPSVQIQAHGDDDVHNGDASTSPASDPVHPPTTTTEVPKITITSSDDDEGSDTDTVAASDMQEDDDRTRTHTGQDFVAATHHIPIDEMLVREFGNRHIWLQVHQDAVTQWALKRKLVLVLLCQLACLHNHAAPRIQERQRLLVGKPLLMVINHLAWVRYVDRFPVFTERVMKYVAWLELLESEYARGVPHWDMFWSAVERRVAPDEGVLEALNRLNDKRLFLHGKILLEEHVVGDLTSEIENTPTWMEWAEAEAEAAADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZY26</accession>
    <name>A0A0D1ZY26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237723.1">
        <property type="nucleotide sequence ID" value="XM_016379046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZY26"/>
    <dbReference type="STRING" id="91928.A0A0D1ZY26"/>
    <dbReference type="GeneID" id="27331784"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04701"/>
    <dbReference type="HOGENOM" id="CLU_079104_1_1_1"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="317" mass="35774" checksum="D35109BB32DD9763" modified="2015-04-29" version="1">MAPVTVGIAGFTGRVATLLASSLLEQDPNVHIKGLARVPDNVAKSISSKSNVQVFQGGAFDPDQIRSFVRGCDVVVCCYSHDDRIMVDGQKLLIDLAEEEGVPRYVASDWCLDYTKLEMGELFAKEASQRIKVYLDSRNSIKGVHMLIGGFAEVIFAAFFRIWDWQTSTLRYWGTGDEIWECTTYRDSAQYTAAVCLDRNAVGVFRFVGDVISTKAIAAALEKVYGVKPKLEYQGSIDELRSTMITEKEKHGDDYWNYVFHWYHYFTLSGKALMGPKYDNDEYPQVKPVKVDEFLKTVPLEQLNGVYMAMDDKIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZY39</accession>
    <name>A0A0D1ZY39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04721</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237743.1">
        <property type="nucleotide sequence ID" value="XM_016379066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZY39"/>
    <dbReference type="STRING" id="91928.A0A0D1ZY39"/>
    <dbReference type="GeneID" id="27331804"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04721"/>
    <dbReference type="HOGENOM" id="CLU_007859_0_0_1"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="683"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="741"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="821"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="894" mass="98553" checksum="7B69DD971B13311A" modified="2015-04-29" version="1">MTFMRPACDDSGRRSSSQERFHRPSLTLERTRTPYHLKAESLGKPIGLSTFSAPDGSASSARSRSESSESGTEADDERGPLLKSLPAPPLRMRKGLRGASPAALTPSASPLSTPPAFVEAREFEYFGTPRKTARKIPQPQKNGKDFEAYKARKRREIVRRCVETVLLGAIGGIIWTSARESPEISDWKSELLAYLLLPPVTYLTVPVRLAFRALAAGKSILQAVRLGFHIPSRFDPGPLLYPVVLPVLIALSLFQRCHTFLPVAIVCGLSSIPPTITATPRVRAMGYYAHWLMTIFPLHASRLRSPHEYLHKPMSLRLNNEGLLQQDDLTLLYPLHQSLMTVLGYLTTSSLDIAELRLLSAALIHLFLFARTPQAEILKAMLWLGGLCIFITCRRILAWEVALARVPTWKLLRKRPRPGLISHVDQAICVVLMRGHLRSRRRESSDSDSEQLPLPPISTGKSTLRLNINGRASEAPIDEPLSAMEPSSQRTAFPDEPVLPTTPRRNTFTVFDRIARIKQSSARKKMRTPLAGPSNVFLSFTIEQARVRKYAYAATAYLCVSATILGPVRLYVGNRALSGHEPFGWAIGYLFGNISKFRFWVVSNNLERWICLPARVSGDAAPDSSFSIEYIRQNIFGPANTRLLICGYCIAVLFVGIFAVLRLTSVVEVDTRRKVFHGIMVAMLLPTIFVDPCFIALALSLVLAVFLLLDLFRASQLPPMSKPLTTFLAPYVDGRDYRGPVIVSHIFLLIGCAIPLWLSLAATPRTGEDAWSGWDTPVRELSMVSGVVCVGMGDAAASLIGRRYGKTKWYWAGGKSLEGSLAFAVAVVCGLATAWTWLRLGGWALWSSGPFSLTFAKFAVAGLGASLLESTLTAANDNVVVPVGLWLLVRGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZZ20</accession>
    <name>A0A0D1ZZ20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238123.1">
        <property type="nucleotide sequence ID" value="XM_016379446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZZ20"/>
    <dbReference type="STRING" id="91928.A0A0D1ZZ20"/>
    <dbReference type="GeneID" id="27332185"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05102"/>
    <dbReference type="HOGENOM" id="CLU_064985_0_1_1"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="3">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="311" mass="34808" checksum="05C3BD24FD89FC5D" modified="2015-04-29" version="1">MHFGSSSIVAVAELVVYVPSIILAFVVCARHGFSRSSGWYYTFTLCLIRIAGAVCQLITRKDHSIGLLKTVLVLSHIGLTPLLLSTLGMLSRIADWINARSPSPSLSIKYFRLAQLFVVLGAVFGIIGIESSSSSSSDGGGGDDHNAVNNSPTTWSKVAVICYVATYAMLLFLMARSLSFRRQLPGKERLLVPAVWVALPLVFVRLLYQVLVVFVHRGDFRRINAPIVVLVLMSVVEEFLVVFIFLFVGLRLDKLEESEQGPILSRPWKNRDRKQRRGGRRRRRQDKYQEPLSSYQAPVPMEYMGDRHGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A1T2</accession>
    <name>A0A0D2A1T2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_03191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239118.1">
        <property type="nucleotide sequence ID" value="XM_016377548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A1T2"/>
    <dbReference type="STRING" id="91928.A0A0D2A1T2"/>
    <dbReference type="GeneID" id="27330274"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03191"/>
    <dbReference type="HOGENOM" id="CLU_011501_0_0_1"/>
    <dbReference type="OrthoDB" id="2110451at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="18"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="8">
        <location>
            <begin position="324"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="820" mass="89716" checksum="C3FF2450FF451D06" modified="2015-04-29" version="1">MDLVATVARRRTQNDHGEGQVGVWRLNGQCVFEAQFERGDTGGGGGGVDEDDTGQGDDDDSKRNEEDEEGWIRGLAWRRDGQMLAVACADSTVALINAFTGKIAHRITTAATVSQSSSSSQSQSQSQSSSKSPRPHTPSSTPTCISWNTHFAAPTSSAIRTRLEGPDSQVTLDEILGLRADVDKLLRMKADLPRELGALDIEVSLPKLATLPPLGVGSDDDIFSSRSSIDAVFHANGQAGSGHGDSVDRVDALLVGLQSDNGGHRCAVHIRIFDSFEIGTVDVGACLPGGSKGGKVVKIESHPFLSTALLVVEQMTDDGPATLHLLGLDMSFISQTGRHLPVVAKKATQLGNLLRYVAQIHTQLASEVKAAFDLPGRFLRNINEYLGDGDDYVDFVHAAHHLAVTGECDGKLKEWLVDEVGERGLKRWEKAVGDCLDIVRRLTSECLMPALERCQVVLTRLDGLAQFGPTSSRLGLEEKNVRKVMETVNALGILAEDLLADVKVEIVEFTAFMKWLKWECEVEALEETSERAAELRESWTGENELLRVLDYVGGAMKDSRIKKYIVPDGPEQSAGALIEDDTDAGFFLDYMKRRAAPPPKAKKNKSMPTFGQVVGRLQTQAERVFAQIAETFRKSILPSHMLEFPRRCDGRRLDLRIVPDVHDRTIYRLYCMARDRSEEGSLQYIKSIMQQDGGGKGLRFGPAELPPARIREAKSILDVKFVDEDTCMVLATTETDIRIFSRLLASDVQADNWEVHHVFDSGRMNAGMTPARLEVNGRVGRRAVAVVDDAGLGYTVLDLDAADGSVEEEGEEMDDEIMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A2D9</accession>
    <name>A0A0D2A2D9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_03384</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239308.1">
        <property type="nucleotide sequence ID" value="XM_016377738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A2D9"/>
    <dbReference type="STRING" id="91928.A0A0D2A2D9"/>
    <dbReference type="GeneID" id="27330467"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03384"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="32"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW19092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="288" mass="32594" checksum="630B2AE76A98196C" modified="2015-04-29" version="1">MAHQAPTKLDINTSYTMNSGYKIPALGYGVYQTPAAECEEVVLHAFKTGYRHVDSARMYRNEQPCADAIRASGLRREDVFFTSKVPPKSMSYEAAKKAIESSFAQTGLDYIDLYLIHAPYGGKEGRCGAWRALAEAQRAGKIRSIGVSNYGVHHLDELEEYIRNSGVGGTLDVGQWEIHPWLPRNDIVEWARRRNVVVEAYCPIVRGERADEPVLQALSKKHRKTWAQVLIRWSLQKGYVPLPKSVTPTRIEQNADVFDFELDEDDMKSLDMPNSYEPCAWDPTTSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3Z8</accession>
    <name>A0A0D2A3Z8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Abscisic acid G-protein coupled receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239788.1">
        <property type="nucleotide sequence ID" value="XM_016374512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A3Z8"/>
    <dbReference type="STRING" id="91928.A0A0D2A3Z8"/>
    <dbReference type="GeneID" id="27327228"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00145"/>
    <dbReference type="HOGENOM" id="CLU_039213_0_0_1"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="7">
        <location>
            <begin position="201"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="6">
        <location>
            <begin position="332"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="58267" checksum="2C7FD5236F9214AC" modified="2015-04-29" version="1">MLPQSAVEDCDECTPDYLNPSRQFGTKAAFSTLPFITTFALLTFVAYRKVYPLLSSSPQAFDGHKGLPRPATSSVEPATQHLARRIAASTFAATIGLSAVLTELLLCEISNSFNPTARTVALQITVASLLGLLVVAIPLLGISSVVAKSGYRFRGQKRAQVRLAWVLEFAGYAAFLLAFWAIGALLPSSASISESLSRHEGLFQACLDRLAITGVSFMALLSGFASVSAIWQCFGPRPRLVTENDITRKQAGLDATLHMAAQKREQLRALEQRSLESPPANFWGWTIQPFRGNQHTQERKILELELSGLETMSSELETSLSIMRSRHATQSKATTIMGRLSLTFSYVFALYCVCRICTTTVNIIQRMFSRTSPTSDTDPVTYSIALFARHVYPSLDRVSWAQQISFLLSGAMLLASFTAVTQTFQLFARFMPGVVHATRTNFALLISQISGMYVISSAIMLRGMMPKEVGSVINSALGAGLLEPAWVQRWFDGFFMFAVFGTAGGIFIGRKISGGLAFDDDMAWDGALGSGKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7W2</accession>
    <name>A0A0D2A7W2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_01456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241093.1">
        <property type="nucleotide sequence ID" value="XM_016375817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A7W2"/>
    <dbReference type="STRING" id="91928.A0A0D2A7W2"/>
    <dbReference type="GeneID" id="27328539"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01456"/>
    <dbReference type="HOGENOM" id="CLU_089740_1_0_1"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW20877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="243" mass="26350" checksum="1ADDD0A50DB46EE6" modified="2015-04-29" version="1">MSSPPQKVSLYSVNDLKNATDDALAPYLTSLPKPYTFKQLHSSTNVRLILGYTAVIIAGVLFYADYKLGWDATKAYTGPACVAYFVLNSLLTYWIWAVEAGTVFVGTREGGQKLTLKSSSQKYSPSYKLKVSYEAPSGKKWENKEIEGSFTQWFNTHGYLQKKEFQSWLAENIEVLGVAKKEGKAAISEPATDNIEPIDDATLAAISSAGGMNFSSGVDAVGPAPPVPATPSTTKKGRSKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AT07</accession>
    <name>A0A0D2AT07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_11959</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230074.1">
        <property type="nucleotide sequence ID" value="XM_016386266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AT07"/>
    <dbReference type="GeneID" id="27339042"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11959"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="69"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW09858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="567" mass="63302" checksum="A4484BFADF87ABE3" modified="2015-04-29" version="1">MTDRRRSSVVQVERANDGVARINDESIRKLSIINPQVVQEFEEAKKAVEKEHELTVRDALKLYPKAIIFSIIFSSAVIMEGYDLSLMGSFFGFPPFRNFYGTEDNPDGGRNIGAAWQSGIQNGVQVGSIIGLWLNGIISDRFGYRKTMLVSLVLMIAFIFLPFFAQNIQTILAGAILCGLPWGVFQTITVTYASDVTPVVLRPYLTSYVNLCWVFGQFIAAGVLRGFLNRDDQWAYRVPFAIQWIWPPIILVGVILAPESPWWLVRHGKLDEARKALLSLTKASSGVPFDVDKQVAMINATNELEKAMSEGTSYWNLFKGIDRRRTEITSMVWITQAFCGAALMGFSVQFYERAGLDSENSFNFNLGQYAMGAVGTVGSWFLMPHFGRRTLYLWGLVILFALLMIVGGMGVAGTSRGPSLAAGTLLMIYTFVYDFTIGPVCYALVADIPSTRLKIKTVVLARNLYNVGGIINNTLMPRMLLNTEWNWGAKTGFFWAGACALLFVYMYFRLPEPKGRTYGEMDVLFENKVSARKFRTANVDQFAGHSTELVEDSSDGEKNSSRQVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATK8</accession>
    <name>A0A0D2ATK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230254.1">
        <property type="nucleotide sequence ID" value="XM_016386122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATK8"/>
    <dbReference type="GeneID" id="27338897"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11814"/>
    <dbReference type="HOGENOM" id="CLU_012769_0_0_1"/>
    <dbReference type="OrthoDB" id="4160666at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="977" mass="108408" checksum="3D74481F826527B3" modified="2015-04-29" version="1">METHGKASAQEDITINESFVQGDSGVQTVDLNGTSEPPASTESNRWTGMRDHNKASFTPSETQVDELADSEAIADSSASEVEGNPSQSSTAPIHTGPPASPRTAPGFRDAKIAFAIDISGSTWGPVLEAEIRAVREISSLLPGPTRQEVTVLPWSDFAHLPARLLDLDELDPDGGTRPSVIIDDPECRYALQESSFWFLMTDGDILPPDVRQFARGLVEYGLHALASVVAIFGEREQPPAQCNVSVGLSVFAVSPHCAFLYTDTATYQTYVLQTKGCFSALLPRGKTNPKLQDDTRWQDLPRISYENLARINVPPRQTVGADEVVLSDNSRVNLSRLLSNSEVNMDVAHQILDNEDNVKTVALTAKLRGQADELRKWLDAVERTHEEAYRSASMEQKSTGQDSNLFTNAISQLMAEETSDSVRHSPTQVRPVVIHNMAPFPPPPPSPLGSPQASDSLAAVGLSSLGPLAPPSVAQQSHRRTSSGISHCRRVSENNDSISASNNIGSVDYDVYADYLSPLPPETSLSATQQTFRRVDRSSYSENLSIPGFRKPQFQKDFFRGRCPRCGREDRVLALLLGPCAEDGRTENFPPPQSSSRLFYPLTMGNYPETDIISTTIRCDHCSSRLLKNSSLPDDRKFEAALPLVSFAKNEAAWLQTVNLATQKRFCTDDLSLIFLSILYTKLERLLDEEPSDEAFTLRLGIEWACGTLLREVRTCNLRVLSPVPMLEVLQTLEDDIVSTFRLALEGQSATPLLRYPLDGFIITNVALSNTKNKTKFSVAKRQRLVFLRFLFYLAERYEEIASESGEVVLEALKLHILLLNDPNTSRSLLNLERLRQFSVYDTKNLVKNLPKRWGGGRRERASRHQRLSISVRDLLSTPFLDEQTLRVFQRLGGLFTWVENHTSHAIAVFLHYLFYLDTPLIRAADRFDGIRAGPEIREVMENPTKVSANIAEVLIEKVQTQLLFAPKGDAAVKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AU76</accession>
    <name>A0A0D2AU76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_11265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230519.1">
        <property type="nucleotide sequence ID" value="XM_016385575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AU76"/>
    <dbReference type="STRING" id="91928.A0A0D2AU76"/>
    <dbReference type="GeneID" id="27338348"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11265"/>
    <dbReference type="HOGENOM" id="CLU_110897_1_0_1"/>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW10303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="93" mass="10509" checksum="EE07BB8B4D638F68" modified="2015-04-29" version="1">MATKYAFTQGLRELRFHLCSSGQGSEATRSFLKRAYPTMKHHNPNTPILIREAVGVEPKVWVRYGLGKEKSETLSGLSDKEIEEKITTLVKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AV64</accession>
    <name>A0A0D2AV64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230586.1">
        <property type="nucleotide sequence ID" value="XM_016385642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AV64"/>
    <dbReference type="STRING" id="91928.A0A0D2AV64"/>
    <dbReference type="GeneID" id="27338415"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11332"/>
    <dbReference type="HOGENOM" id="CLU_002406_0_0_1"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="827"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="858"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="928"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="997" mass="114184" checksum="D204D33011C91B71" modified="2015-04-29" version="1">MMAFVQGQPHPLIKEAFTKFEALVGVNDARLFKSTILANVREAAQIIERDQSQRRCLRNMRRIEPLFDALQKLAGPMETLCSGTPYLCFIWAPIKLVLHIVDEYTNAFDQLLDAYREIAQNLPRCDRLGTAFCDQDGFQAVLAEIYSDILEFHTYSYQYLRRGGWKSLFDASWKSFSRRFNSILQRLARGRDLIDKEAQSFAILEAKEFRQQVLEKIERFEHDRHDWQLRDTLSWLDLKGQDREQDDLFECRSSARKPGTCEWILQNPKVRCWLDPEDCRSQLWLRGKPGSGKTTLVTFLYDNAPIPPNSFILYCLCSYGFARSEANVCGLVFRSLLAQLVRKQRSLLSHVYYNFVNTGVVLSASKARDLLKSLLQASGPAFLMIDGLDECEGIHQRQLLSDMRQLLVSTKPISENEVPIKILICSRETKDVGGSLKKVPQLFLTEEKDKVSKDIAEFAKDGLSPLKERFDATVVAELEQDVVEKADGMFLWVQLVLQMLLEQHSVRDLRNAVEEMPTDLPGVYASILNRIQKACNEEQKNRLKHIFGWLAFSYRPLKVHELCDLVVFQKKHVLLDDNTKLRASVLEMCKPLLEEHGDHSVTLVHFSTREYFLHEYSGPYLPRQQIHLSITQACIRYLMTCQPFTSESLTGQTRTEIVKGFHDIYPYVNQFWANHLVECFRDVPTIVSDEDSRAKKEVYSLLIALLQSFQVDGQDQSNEAGDNPTTTLTHTRILALEDLPSPILQVLDLKKGKNAKGEALSLNRVLTKRPPRQAILEDPVSLNAAFSCFQNSFEALLTDQPSDLANELGVSLTEIIEFKTRHSYAAYLCRKRGCVRASVGFQSPEERSKHETCHDEKFRCPEPACDFSVRGFPSRSGLQRHYKTYHRNPDDIVLPPFPSSRHVDNDEADPSWQIPKAQMDSPRIRTPSPINGFTSKSGHNPNMDQAPVGSLRFDFSTLENNDVIDNFDFDRFLNSTSDDIFNFDGVDLSRLMERNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWL6</accession>
    <name>A0A0D2AWL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231299.1">
        <property type="nucleotide sequence ID" value="XM_016384697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AWL6"/>
    <dbReference type="STRING" id="91928.A0A0D2AWL6"/>
    <dbReference type="GeneID" id="27337465"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10382"/>
    <dbReference type="HOGENOM" id="CLU_050242_0_1_1"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW11083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="354" mass="40080" checksum="25930A6E31537A9D" modified="2015-04-29" version="1">MADGSHENDVATTVAQPLDSIASSALLQTLSDTSTETCVICLDHITQKAIARPCRHDQFDFHCLGTWLQRQQVCPLCKGHVDSVRFGINEENKQGSQIFYLPEPELPPPGRQSVASPSASFDRRARFATLHSRNTRRHRSTRARNDGPNDTGTLDFRKQVYQRRLYSLHVGTNRLSRYRNLTPDSFAKDQPWQSRARMWIRRELGVFDFLNSASTVDSPGNSGSSSTADRRAGNAGFLLEYIIAILKSIDLKGSSGQAEELLKDFLGRENARLFLHELESWLRSPYEHLRDWDRAVQYSIPAESGQEGGEAMSRSSSVSVPPRQRPRDHSAATVPEWFSDRFVLQRENHRDRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AX39</accession>
    <name>A0A0D2AX39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_10279</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231196.1">
        <property type="nucleotide sequence ID" value="XM_016384594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AX39"/>
    <dbReference type="STRING" id="91928.A0A0D2AX39"/>
    <dbReference type="GeneID" id="27337362"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10279"/>
    <dbReference type="HOGENOM" id="CLU_079283_1_1_1"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="10">
        <location>
            <begin position="45"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW10980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="203" mass="21670" checksum="9FC580DB6168DB38" modified="2015-04-29" version="1">MSRRALLGVPRAISASAQSSVRPSFASRTPLLRPAATQPTQRRSYHEKVLDHYSNPRNVGSMDKNAVDVGTGLVGAPACGDVMKLQIKVDPDTQKISDVKFKTFGCGSAIASSSYLTELVRGMTLEQAGKIRNTEIAKELCLPPVKLHCSMLAEDAIKSAISNYYTKNPNARQTDLGSASASMPKIEIERVTATTDTGASATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AY34</accession>
    <name>A0A0D2AY34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231829.1">
        <property type="nucleotide sequence ID" value="XM_016385227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AY34"/>
    <dbReference type="STRING" id="91928.A0A0D2AY34"/>
    <dbReference type="GeneID" id="27337998"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10915"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF265">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="445"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW11613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60371" checksum="D68454C6B2982577" modified="2015-04-29" version="1">MPFLAEKSAPISNKDILSWMFDEPLFDQNKPVYIDALDPANSISGNQARKIIRQLAAGLHAAGIRPGDCVCLHGFNSIHYSMLFLGIVAVGGCFAGTNPAYTQFELTHHFKTSQAKFLIVEPELLANVVPAAKECDIPRSSIMMFDTQNEAIPPGFVSWRSLLAHGERDWVRFDDERTSRTTTAARLFSSGTTGLPKAAALSHYNLVSQHTLVYEYNPSSYEPSRLLYLPLFHAAMVPSAHVSPLRAGHVSYVLRRFELQPVCEALAKYRITEMTLVPPVAMAMLKFPGIRDYDLTGVKAIFCGAGPLDKEHQNALLLIVGGDTSFTQVWGMTETSCVATKFYYPEKDDTGSVGRPIPNLDIKLIDDDGKDITAYDTPGELCIRGPTIITSYFDNPTATADSFDDEGYFKTGDVMYCKAGTKKWYIIDRKKELIKVRGFQVAPAEIEGVLLAHPHLQDAAVIGIQKMDEPEVEMPRAYVARKPTPEGKKLTEAEVRSYCDEKLAKYKSLTGGVRFVDAVPRNATGKALKRIMREMAKAEAGNEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZ22</accession>
    <name>A0A0D2AZ22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231936.1">
        <property type="nucleotide sequence ID" value="XM_016385334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZ22"/>
    <dbReference type="SMR" id="A0A0D2AZ22"/>
    <dbReference type="STRING" id="91928.A0A0D2AZ22"/>
    <dbReference type="GeneID" id="27338105"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11022"/>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="105"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="340" mass="37428" checksum="DEA73F275DEC736F" modified="2015-04-29" version="1">MVQLPPGPPEWQGPPPKNGHLSDIDPEFAKYKDQLDKDLTALWELPIDEFKAAWLSAPVSLPDNAPQPGQDYIVLDQVAPVRDGTEIGIRVYRPVKSEPGMTLILKSHGGGWVVGSHEVEEVENRFLAAKAGAVVVSVDYRMAPEFRYPYAVNDCFDVLQWCKRNATDLSINPERIIVAGGSAGGNIAAVLAQKARDENVSGVIGQILNIPVTCHPDFFPSDRYPGGSYQQNKDASIVNAPQMFWYWNQYMPEPSPEAYASPLLAKDLSGLPPALVQVAGLDPLRDEALAYAEALEEAQVPVTLRVYKGLPHAFYLLPQLKQSFEFWMNSVDFVVSLGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B052</accession>
    <name>A0A0D2B052_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3CxxC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232271.1">
        <property type="nucleotide sequence ID" value="XM_016383648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B052"/>
    <dbReference type="GeneID" id="27336412"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09329"/>
    <dbReference type="HOGENOM" id="CLU_089692_1_0_1"/>
    <dbReference type="OrthoDB" id="8121437at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="4">
        <location>
            <begin position="56"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="162" mass="18117" checksum="C99759BAB08C1407" modified="2015-04-29" version="1">MPKRRSGRDNGGESRVLFRFPGLHKDVVKAVSGEMASPRFHGRGSNQTPNREYSTHVMGRFECKNSACSSGGWASKKIAIVIKGFPDNGYNAEVYNQRCKFCDKLGTLILDKESYVERVAYRIKRWAGVEVEHPHYGPKKGLPHESAHCEGCKRGVCRETSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3D8</accession>
    <name>A0A0D2B3D8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233366.1">
        <property type="nucleotide sequence ID" value="XM_016382663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3D8"/>
    <dbReference type="STRING" id="91928.A0A0D2B3D8"/>
    <dbReference type="GeneID" id="27335420"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08337"/>
    <dbReference type="HOGENOM" id="CLU_022730_0_1_1"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="466" mass="51717" checksum="08017FB3277EF8C7" modified="2015-04-29" version="1">MAFPHPQPMTSYWLSAAADLANHRTTESLPTEADVVIIGSGYSGSAAAYFLATGSRDGNTKRPSTVILEARQVCSGATGRNGGHLKPDTYYSAAEAYQKYGAKVADELIKFERQQVFDVKRLVEEEKIDCDFELTRAIDIFTDQQTADSVMKTHNEMKSNGFSFPDDLHVIDDPKRAEQISGVRGAKAAFSFTAGSVWPYKLVTHLLRRSIEMGANLQTNTLVQQISADQADGRWTVKTNRGEILARKIIVASNAYTASLLPEFKEKIVPVRGVVCRIAVPEETGKRAPHLNNTYALRFNPEHFDYLISRSDGSIVVGGADRCAVEKQAYWYENTDDSQLIPETEQYFTGYMQRMFNGWEDSKAHITDIWSGIMGWSNDSMPFVGRLPGKPGIYVTAGFTGHGMPRILGCSKALVELVQSDGETIDMNTKNGIPIPYLLTDARLEDKTSDIFSYAQKDESDLKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3V8</accession>
    <name>A0A0D2B3V8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine aminopeptidase 2</fullName>
            <shortName evidence="8">MAP 2</shortName>
            <shortName evidence="8">MetAP 2</shortName>
            <ecNumber evidence="8">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_08553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233581.1">
        <property type="nucleotide sequence ID" value="XM_016382878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3V8"/>
    <dbReference type="STRING" id="91928.A0A0D2B3V8"/>
    <dbReference type="GeneID" id="27335636"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08553"/>
    <dbReference type="HOGENOM" id="CLU_015857_7_1_1"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF1">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="11">
        <location>
            <begin position="160"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW13365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="478" mass="52060" checksum="41CC9EA2D484D04A" modified="2015-04-29" version="1">MGSKTPQNGDHGGYGEANSPVETNRAGGEPRGTHTSRDGDGCLGDAGGEGDSDDDDDGADKETSLATLEPPSSIVGATTDAPKKRKKPKLKKKKKNKAPEGAASLHLKQSSPPRIPLSDLFPNGDYAEGEVQLYTRGPKAAAEARYDDLRRSHDAVFLHNYRKAAEAHRQTRQWLQDTVKPGDKLMDVANGIDDSVRALLGHAGLEPGDGLKAGMGFPTGLCLNNQVAHYTPNPGQKDVVIQQKDVLTVDFGVHINGWIVDSAFTMSFDPVYDNLLAAVKDATNTGVKTAGIDVRICDVSAAIQEAMECYEVEISGKTYPIKPIRNLSAHNIGHYHIHGGKSIPFVKNSDTTKMEENEVFAIETFGTTGRGYIYDDAGIYGYGLKEDAPLKVSLPLASARRLHKTIRENFGTLVFCRRYIERLGVDRYLAGMNSLISHGIVESYEPLRDIPGSYSAQFEHTLILHETHKEILSRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B487</accession>
    <name>A0A0D2B487_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233706.1">
        <property type="nucleotide sequence ID" value="XM_016383003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B487"/>
    <dbReference type="STRING" id="91928.A0A0D2B487"/>
    <dbReference type="GeneID" id="27335761"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08678"/>
    <dbReference type="HOGENOM" id="CLU_016577_0_0_1"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16984">
        <property type="entry name" value="CID_Nrd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000026">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000397">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF4">
        <property type="entry name" value="PROTEIN CBR-NRD-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="8">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="459"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="586"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="644"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="72307" checksum="A7F3112F133EC012" modified="2015-04-29" version="1">MSSAVAELDSILQSMLSLKPPGVSGSKISAITSLCTANIQSESVLIQKIYTHFKKTPGTHKLGVLYVVDSVTRQWVDQARKAGQQIGSGAADGTFAAGVNRVTELLPVLMNDIITTAPEDQKVKINKLLEIWDRSQTFPAPLLSSLKEKLNAPRVSTTPEGSPAPGFVPLGQQQAATAMSATQPSTAPAQQDTSAILEALKNMAKQNAAAPQPSAVPAPASLSSLLGAQTGTPLPTSTVNQSPAAAGGSVPGVNPLGALLAGMNNGVQSQSPANVPQNPLAAFLPQPQAPVPIPQNPVSINPDIQAQMQLVQLLAAQGVPPDQWATALQLLNMQNAGGSANAMPFQPPIQANNWAAPNGGQSRDAHTRSPPGQYRRRSRSPGYDKRRELSPRRHRDSPGADQYRDRDGRRGNDYRQRSPGRRRRSPSPQGHDPSLPPPGPKNVTFDRSLPKGHIKVYSRTLFVGGVTTGEASLRQVFSQFGIVQTCIVNIDKRHAFIKMINRQDAEAARHGMEEYKLGDSQLRTKWGVGFGPRDCSDYSTGVSVIPIERLTEADRKWMVTAEYGGTGGQPIQEFMVIEEPDIEIGAGVSSKAMSRRIPTDSGGRRGPQSSRQHGGRDERRRDDDRRVDRDERSASNGNTGAMAPMGFPMNFGNGMPMFPPGFQFPGIQQNQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4L9</accession>
    <name>A0A0D2B4L9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234094.1">
        <property type="nucleotide sequence ID" value="XM_016380992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4L9"/>
    <dbReference type="STRING" id="91928.A0A0D2B4L9"/>
    <dbReference type="GeneID" id="27333742"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06659"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="8"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="346" mass="37417" checksum="B31D75DB85C27206" modified="2015-04-29" version="1">MKAVVYRGKKAVVEDRPVPKLRDDYLLIKVNAVALNPTDWKHVENQMPAEGGIIGCDFSGTVEEVGSAVTKPWSKGDKIMGVAHGGNYVQPEDGAFAEYIVAKGDVQMKKPDRLTFEQAATVPLGSVTVGQGLYQKALELNLPTDPVKTKEYVLIYGGSTATGSLGIQYAKLSGYDVITTCSPRNFDYVKSLGAVEAFDYNDPDAPKKIREFTGNKLRYAWDTVAEGKSPQFCADALSDSLSQVGSCAYGATLPVKFPRDDVKATSTLMYSIFGEAFDFAGTKIPALPEDFEFAKKFTSITEKLLAEGKLKTHAEEVRGGGLDAVPQGLEDLKAGKVSGKKLVYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4V9</accession>
    <name>A0A0D2B4V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233956.1">
        <property type="nucleotide sequence ID" value="XM_016383253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4V9"/>
    <dbReference type="STRING" id="91928.A0A0D2B4V9"/>
    <dbReference type="GeneID" id="27336014"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08931"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF3">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="13"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="364" mass="39933" checksum="AAC3CC705F970EC3" modified="2015-04-29" version="1">MTTHSAIVTVGPGLPLQVIQVSTPVPIRDQVRVRSEWTASTPLDLHQADGGLLVTHPQILGDGVAGTVVEAGPDVSTLAVGDRVFGFTWRNQAEKAHQEFVVAPEYLVGKIPASFTMQQAVTLPNNFVTVWHTLTKDFGFELPWPKPDEFVPTEAAQAILVWGGASSVGQYALQILKYYGYKNVIATASARHHAKLLRYGAAKCFDYKDAGVVHDILDFLRSQGNNTFFAYIYDCIGSLQGSVRPVAKLASAGCKVAILLPVIVKDAAQGIKPEYEMDVNTCADWQSGVKVAGVRTHFYLDNKFLAEKLQSEIMPTLLARAIVEPNQYITVEGETMLERATKALEMLRNKQVHGARLVWRVADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6E1</accession>
    <name>A0A0D2B6E1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234476.1">
        <property type="nucleotide sequence ID" value="XM_016381374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6E1"/>
    <dbReference type="STRING" id="91928.A0A0D2B6E1"/>
    <dbReference type="GeneID" id="27334125"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07042"/>
    <dbReference type="HOGENOM" id="CLU_1562897_0_0_1"/>
    <dbReference type="OrthoDB" id="5398665at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="171" mass="18263" checksum="88491707A1DE78E2" modified="2015-04-29" version="1">MDVGETSTTNGSNNGTEQTTTTPELTSDSEEEEAIVVEPEVLEAAAVEGGMLYTMTATNTTDNAASGHAGEQADAEADAEAEAGVEGEEDKQQEEEVPIHEAIMTSNTYLTIAAITADQQAAFEDNDLVLHFQPGIEPPILGFDPRVVQDDFDPFDLDFSGLIDFNTNMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6F8</accession>
    <name>A0A0D2B6F8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_07232</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234664.1">
        <property type="nucleotide sequence ID" value="XM_016381562.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2B6F8"/>
    <dbReference type="GeneID" id="27334315"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07232"/>
    <dbReference type="HOGENOM" id="CLU_000684_1_0_1"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="11">
        <location>
            <begin position="84"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="8">
        <location>
            <begin position="84"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="453"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="517"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW14448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="2150" mass="242108" checksum="838EAD5D0C6B0376" modified="2015-04-29" version="1">MSLPPSDLDRQLRQALCDHPRRYGYRYSDTARNSLLEGLFRSLTNDRSDYLHELFPNGFPPSYKLQDAQGVQENVEYTDAARGHPCGHIFKAGEASYHCSTCTDDSTAVLCARCFVSSDHEGHQYIIQMSPGNTGCCDCGDDEAWKTPIQCAIHTARDDWATTDEVVSPLPQDLQESIRVTVSRALDYFCDVISCSPENLRMPKTTETVTQDEARSRLLSEHYVSGDEVEANPEFCLIIWNDEKHTVREVQSQVARACRQRESWGLAKAEETNDIGRSVIRFSRNLSELTRMAKIIEEIKVTVTIRSARDTFREQMCGTIIDWLADIAGCSVAGDSHVLRRIICEEMLQIWRVGSEAWNAKVGKEDLDDHGEEDDREFRRRARVIPFDPIQFAMQRIVAEGDDMLTDEDNEPMDPDEDEDEDDDEDDELGDVEVGLESNDLILRTIAFEDTEDANSIVEHSGDAEATDDADEMDTDGDGDGDFLDVAERMDTDPTSPAPATVPGQNTINPEDGIRVGGADTPAAADTNANYLNVPRTPAASSRPSSSQSPPPDHWKLSKPGQSASGTSLPVYEDLTKNIRVDSMILFDLRLWKLARSNMRDLFISTLVNIPQFKRILGLRFSGLYTTLAQLYLVADREPDHSIINLSLQLLTTPSITEEVIDKGNFLTNLMAILYTFLTTRQVGFPKDLDPGATLGFDAGSVANRRLYHFFSDLRYFLASPFVQAKARSEREYLCQFLDLAKLSQGICPNVRAVGEHVEYETDAWISASLLTRDINKLCRQFAEAYYVAKDSNPAAVRATCDAIKHAAGIAIINSVGLERRRFDQAEIKDPVKFHNVGPFGDSTIFSVVDFVVERGSLSFHHPLHYTLSWLLECGKYTKNSIEALREAAQAFLSHLHDTLGARDHAIKQALVTVDDALLTMFDYPLRVCAWLAQMRANLWVRNGMSLRHQMMQYKSVAHRDVGHHRDLFLLQSALVTCDPSRVLASMVDRFGLADWMKYGFVSSEICDDGQMLDLAEDFTYLLINLLSDRDALIADRSNLESQLLAVRKDIAHTLCFKPLSYSDLCARLTERAQDHEKLQDVLKQMTRYRPPEGLHDSGLFELKEEYLMELDPYNSHFSKNQRDEAENIYKKWMAKKLKKSPDDVVLEPKLHPIPGEAYTNLCGVVHTAIFADVMHKTLLYVSQGHKGKTGVTATRVEAFLQIVLQLALIATLEDKISEQGNASSFIGNAIDMHLPSHDEPHSTILDQLHKIWLMDEFTSCRSKIRYILRLFNQKRPQQFMRATEHLEFPSGRFDTSSPANAENEVEAKKRQAMERKARVMAQFQQQQQNFMDKQGVIDWGDDDLDSPDEELPKSTETRHWKYPSGLCIQCREESTDSRMYGTFAMVTDAHILRQTDVGDEDFVGELFAIPDHLDRSIEHIRPFGVAGSNHEQLRRLNAEGQEITVDFQGLGKGWPKHHTMKGPVSTSCGHIMHFACFENYYQSVTRRHSQQVARNHPERIALKEFVCPLCKALANTFLPIVWKHTEQSYPGALGVSQDFDHFMDNDISKFTPASVPMDNNAFDNLASKMYSETLDTFSNSSLTPAITMWQAGDLTISPTSQAWAEKPELAPFAELSGIYGRLRDSLTITARTSYVVPPDSTSPVNHFHVLIDTLANTIASVEIGHRGREAEFGTPLLTCIPQQTLSHVQTLCSTLRAYTVTGALTVRGSTESQFRGLCDHLERQLAGTVTGHEPQNGNPDLALPLLRTDAFQFLVQSTMVLCPLRRLEVRHFLQLSLTLEVLRVALAFMLDPQGFIRASEKLVQNQIRHAVPLQADTEEVQSVKSLLAWMLSMLEPEAARVAGVGQLRNLFLSMTANEYRAMYRLFQVYALAFMRKSAIFFHTGHGIDFPTTVGSEANLPELERLLHFFQLPKLQEILMSFDQFSVHGTLKDRAQSWLSDCYRYAVDIGPAWPQSVSLGIKPLHPAPFELIGLPKYFDTLMEESYRRKCPTTGKEVSDPALCLFCGEIFCSQTVCCLTPELRGGCNAHLDKCSSPVGMFLFIRKCNIALLHVVSDPRTLDLERQRNGRGTHPLLHGSLTLSHGSFFPAPYLTKHGETDPGLRSKHQLILSQKRYDKLLRDAWLMTNGSIWSSIARKLESEVNAGGWETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6K4</accession>
    <name>A0A0D2B6K4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urease accessory protein UreG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234704.1">
        <property type="nucleotide sequence ID" value="XM_016381602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6K4"/>
    <dbReference type="STRING" id="91928.A0A0D2B6K4"/>
    <dbReference type="GeneID" id="27334355"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07272"/>
    <dbReference type="HOGENOM" id="CLU_072144_0_0_1"/>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="54"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="274" mass="29031" checksum="A16BD6F69CE6D237" modified="2015-04-29" version="1">MATHSHDGGPSHSHAHNGAAPHGHSHEILDGPGSYLHREMPIVEGRDFSDRAFTIGIGGPVGSGKTALMLELCLALRNEYNIAAVTNDIFTREDAEFLTKHGALTPERIVAIETGGCPHAAVREDISANLLALQGLHAKFGTDLLLIESGGDNLAANYSRELADFIIYVIDVAGGDKVPRKGGPGITGSDLLVINKCDLAVAVGADVDLMEREANKIREGGPVVRAVIKNGVGVKETVDMILSAWKSTSGYSESRKRWANGGQRGSGEQPKVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6R7</accession>
    <name>A0A0D2B6R7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234591.1">
        <property type="nucleotide sequence ID" value="XM_016381489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6R7"/>
    <dbReference type="STRING" id="91928.A0A0D2B6R7"/>
    <dbReference type="GeneID" id="27334240"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07157"/>
    <dbReference type="HOGENOM" id="CLU_005168_1_0_1"/>
    <dbReference type="OrthoDB" id="3538597at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="872" mass="99653" checksum="252A5049DF5058B7" modified="2015-04-29" version="1">MAAAAKDAGTRRLLRKYNVSFHVDKPEGPLDDDPEAYFKDIKRLGGYSIDRYEFNPTVDSRQMPWREKTVERAKSISAKARRCAEEEKNESGWRLNLETEILARFSIESRPECRRRLWKSEVEVAVTTADGRLKKLVDRQRARKFCNCPPRKRGKDIADDGLIDIFDDRTDETIQYEDEIKQVLDRGKRPDRVFGLRLTKRLERILDFTEGPDGKLVRELITTTPFQDSSRPLLFPFLYLEAKSEKSRDSFSKIDLQSGFALRNLLQLQHNLMHAAIENGEAHMVPLVWYLAYRGQHWHLAAAYVEEGTKDGEPNYHILQLWDGEITFADRALQLLLMLDYIFDWARDVYRKDIISALLSFVPNASSSLLESTDIGSTYNDPPFSFDGDVQEPVMDYDIDPPESFGIPHMLEFFDDGKLAIRDASYVTHRVLALHVTLENLGQFLGKMNSKYKASTLARQLWMSMQGDATWLVTADCLNAIERVWTGHDRESDTFQNPQQVFLASFSVTSKLAGKYGKLTDSKPWNQIHALSYIAIAKSALQELQKRTEYGPRRLMISLTGMPDVSTERATEIFSKLRFAPVRQLFAAAIARSELLSTCKESYRAGTGPGDSLMGFRSYVRTPCFTSALKSPETVGPAELCESIYTLLNSGMSELTESFLRISHQSSKHDIGLEDRDDSSIPKCWRKLPVDKLQTSVAVLVDSGGCRSCYCLFVFGLDTFHSRSEDGDEKNAQDTSERVETHRIYPGIVRTFYRGSRRRYKFYDRSCSADTEDFPQISEILRHVSNQYERILSTDTTSRFDSGHADWFRRRCRFLEGPGTGWPFDFFETVDNIKQIGGTSRFGFILDRLLSLYDTAMSLNPPGEPEEGEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6Y5</accession>
    <name>A0A0D2B6Y5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_07467</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234899.1">
        <property type="nucleotide sequence ID" value="XM_016381797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6Y5"/>
    <dbReference type="STRING" id="91928.A0A0D2B6Y5"/>
    <dbReference type="GeneID" id="27334550"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07467"/>
    <dbReference type="HOGENOM" id="CLU_009049_2_0_1"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="161"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="608"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="778" mass="88997" checksum="0D77050A8B75D87F" modified="2015-04-29" version="1">MPHQRPTSGYARLAQADEEEPLGDEDSDHENHHTTPMTTRYASIQPGPRESMRSGPQYNPGRRTTRRMRSNSSGVDIKAINARLERWAEEIVTKFKINSVKGKTQEEEQLEIHHTVFQAPPGIQPYTAEDLASYAAIETQHMTKHQFDDVVETVRVAIEMGVHPKMISQGSSGSYFARNSDGKVVGVFKPKDEEPYASRNPKWTKWIHRNLFPFFFGRACLIPNLSYVSEAAAYVLDRQLRTYIVPYTDVVWLSSKSFYYDFWERRSSWRGKKSLPAKVGSFQVFLKGFKDANIFLRENPWPDQATEFRADVEHKRKRRPLSNCIPSAAHSDDEEESPRLLSPQPQMEQAPKFHWTPTIKQAFREELEKLVILDYIMRNTDRGLDNWMIKIDWKLEEVSLIAEPPKPQGDGQNGDATPRQMSVSPRPESNTSRPYRRYEAMESRSATPSLGQENNCSITLGAIDNSLSWPWKHPDAWRSFPFGWLFLPVSLIGQPFSKKTRDHFLPLLTSTAWWSETQLALRKVFALDDDFKESMFARQIAVMKGQAWNVVETLKQEDHGPLELTRRTRVCVWDDLVDVPVAIPMRVPSTEMHRKNRRFDQQEEMDIGASYSSAPPGRQQQPTHDLLGSPTMELPNPNRFDLTRDDSAGDVSFASGHEGPASPPVDTSGFDSFDYAKEARNSLGNSASLPPRPTMKKQQNRFSFDFPRREAAPRPSARRQRSMSTRSGKRAPIILYEGDDLEGDLGYAAASDMEQNKRKVIVERLETIKGKQPVFTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B715</accession>
    <name>A0A0D2B715_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234686.1">
        <property type="nucleotide sequence ID" value="XM_016381584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B715"/>
    <dbReference type="GeneID" id="27334337"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07254"/>
    <dbReference type="HOGENOM" id="CLU_411618_0_0_1"/>
    <dbReference type="OrthoDB" id="2534600at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="667" mass="75219" checksum="2CF5706A8A7EB495" modified="2015-04-29" version="1">MPPTELDDERPPKRQRVSRACAPCRYAKLRCNGQQPVCATCRQQRKNCVYETGAKRRGLRSGYVRALELLWGLTLQEIEHAEPTVNNLLGRLSRQDLVASLDRGELNTAAAAVLDRWKQSSILRRLDDLLDENDEENDEAGAGGVPDESQNLRPDHPPGWVIVRYQRDQSEPTSSNVVRPNVNVEVNMSSLESCYASQVSHPPERWPPAYAFQLLLLFLGHGQSWLPILERHTLLRTSFSFQRKLPSIKHGDRAVLWGVYAYASATCGHLLNAAEESRQAKECCNEFRTQAYSMLPLDSDLPVEMGHVQCAILISLTRLGSGAVRASWRLVRMAIQMMREMSRQYGYTVNQDTLAKAWLACFLLDTLTSACLHSQPLLHFCDVANWCHIDESGTEEWQPWCPPTTTNYGPPLDLPTHSLSMLLLQVKLMRILNDYLHNKSTTTEKSRNDLIDWNQELLSCLSRERLTSILQREDLEILQLPPSFTNLSIIYTGVWKRIMKQPQDPRCTPSLSGCGPTYPLLSHTNLQKLQQDQTAYSRLPALQLLTWDGPVSGLNNRPDNSVVVSEPALELLEDVNLVIASLDPPRTIPEPNSSLAMDMAEPMLPEVSDISTQAREPFTSFDAVSNPNRMVDAEQGSGSEFPSFDCYMDSTDAPFLEYLDTLDERPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B858</accession>
    <name>A0A0D2B858_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 18">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PV08_07650</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 18"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235081.1">
        <property type="nucleotide sequence ID" value="XM_016381979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B858"/>
    <dbReference type="STRING" id="91928.A0A0D2B858"/>
    <dbReference type="GeneID" id="27334733"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07650"/>
    <dbReference type="HOGENOM" id="CLU_018693_4_0_1"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="23">
        <location>
            <begin position="162"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="483"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="541"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="19">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KIW14865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="591" mass="67346" checksum="5DE9712DFAAF4997" modified="2015-04-29" version="1">MATSNPSDSVITDNQSLGVADGQAPTHTYVPNQGYIDGSGTGHQRRLALGQFIQEDDENDDDDDEDGEDYEEYYDDGDVDTNRLVDPDDLASGNPSDLTKSYNRQRRLDDAMANPNVPSWQYPKANPQKSSKPDMGELGYGMKKLKIEGPESLPTGPSKGKDKSDRATSEQVLDPKTRRILFQMINSGIVSEINGTISTGKEANVYHAVAASDDPDEPDTHVAIKVYKTSILVFKDREKYVTGEFRFRKGFNKSDNRAMVKLWAEKEMRNLKRIHAAGIPCPEPLYLRRHVLGMSLIGDSKGKAAPRLKDVEFEDDNPVARWRDVYLDVLAYMRVMLQVCKLVHADLSEYNMLYHGGKPWVIDVSQSVEGDHPRSLDFLRMDIKNVNDFFRRQGVSVLIDRKVYEFITNQTKSEDDVQMDVMRKDLDRIMAERKEGEDDEVENEVFRKQYIPQTLDEVYDAEKDAETMKTAGRDALVYKDLLAPDKAELQREASPDEEEEEDDDDDQDENFGAPLQRVESHSQDESGDEHSGGESGSSSEETGRPRGKRFQDKDEKREHKRKVKEEKREKRATKMPKNVKKRLVKESTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8V9</accession>
    <name>A0A0D2B8V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235574.1">
        <property type="nucleotide sequence ID" value="XM_016379747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8V9"/>
    <dbReference type="STRING" id="91928.A0A0D2B8V9"/>
    <dbReference type="GeneID" id="27332487"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05404"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RAB GTPase Vps21/Ypt51, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="26500" checksum="F35A4BD60444E0B0" modified="2015-04-29" version="1">MADPSSAPKPSSSVKLVLLGEAAVGKSSLVLRFVNNDFQENKEPTIGAAFLTQKISLPNRIIKFEIWDTAGQERFASLAPMYYRNAQAALVVYDLTKPTSLTKAKHWVAELQRQASPGIVIALVGNKLDLCAESSGDSEASPEDGEETESNTEAEPTDNGDARKISTREAKSYAEEESLLFFETSAKTGINVAEVFSAIANAIPETSLKGARGASGGGTQAALSGAANRADEARVNLADRAKQKSNDCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAH3</accession>
    <name>A0A0D2BAH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_05613</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235781.1">
        <property type="nucleotide sequence ID" value="XM_016379954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAH3"/>
    <dbReference type="STRING" id="91928.A0A0D2BAH3"/>
    <dbReference type="GeneID" id="27332696"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05613"/>
    <dbReference type="HOGENOM" id="CLU_002656_1_0_1"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="476"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="210"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW15565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1070" mass="117972" checksum="16807CA761386421" modified="2015-04-29" version="1">MAPKKKGGKKQADDWDADMGETIDPIAQATADAKKAEATEDAAEEEVNAGGLMAALRKNRDKRAKKGKPVNDFVEGEDADGAAPTPPAEDFAAKAPAEATLDDEDDVFAGNAKKTKGNKKQADDGDDGEGGGVKSKKEKEREKKEREKQRKKEQAAKKKTTAPTPAPKAEEVKPVEEKKPEVAAETDKAGKKKKVPAHLAAIQKQQEALARQREEEARLEAEEKALEAERLRKEAEEEAKKAEARQRKKEKEKEKKEQLRKEGKLLSEADKKRKQQQELRLQQMLEAGVKVAGLSETTEEKKKPAFDKKRKGPKKEEVDLEAAAEKARQEAEAAAAERERLAKEAEAAAAAAEAANAGNDEESELDDWEKAADEDVKDSWDADSDEEPAKPTVNGNAKAAINGAATKPSKSSTLPLRDGPPPKERPIESDTSDEDSSDDEEQTSNQRAIAQRKAEAAARRQKAHEEALAARSKDNLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATYFPVEALQQKTAVVNKDGKFEFKVPGLLVIDTPGHESFSNLRSRGSSLCNIAILVVDIMHGLEPQTIESMNLLRERKIPFIVALNKIDRLYGWKKIDNNGFQESLAMQNKGVVNEFKDRLDKTKLAFAEQGFNAELYYENKDMRRFVSLVPTSAHTGEGIPDMLKLLVTLTQERMTSSLMYLSEVEATILEVKVIEGLGTTIDVILSNGVLREGDRIVLCGINGPIATNIRALLTPAPLKELRLKSAYVHNKEVKAALGVKIAANDLEGAIAGSRLLVVGPQDDEEDLEDDVMGDLQKLLTAVSKDNRGVSVQASTLGSLEALLKFLKDMKIPVANISIGPVFKRDVMMAGTMLEKAKEFAVMLCFDVKVDKEAQQYADENGIKIFTADIIYHLFDDFTKYRNQLAEQRKEESKLNAVFPCVLHPLQVFNKKDPIVVGVDVVDGSLRPLTPIAAVRTNPVTHVKEIVSLGRVTTIEREHKAIPICKKGQPAVAVKIEGPNQPLYGRQLDEKDTLYSLISRQSIDTLKEFYRDEVTKEEWSLIRKMKPLFDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAT3</accession>
    <name>A0A0D2BAT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236279.1">
        <property type="nucleotide sequence ID" value="XM_016380452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAT3"/>
    <dbReference type="STRING" id="91928.A0A0D2BAT3"/>
    <dbReference type="GeneID" id="27333197"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06114"/>
    <dbReference type="HOGENOM" id="CLU_061825_1_3_1"/>
    <dbReference type="OrthoDB" id="5223589at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="19992" checksum="F4F0CC35845EA8A5" modified="2015-04-29" version="1">MAVILPGATHDLFITANIGMSLGCFLLAGYITGQLSHIIGPRNRAWIVFCNFFQTGLVFIAAALQYIYGIHVEGTSTVIIIGLLAFAAGSQVVLSRSLSMTEISTAMATAAWVDLLIDKNLLALSNRPRTRRASFLAALVAGAFFGAYIYREVGSEAALLLSAAGKLIVTIMFLFNGIEKPSVCQGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BB18</accession>
    <name>A0A0D2BB18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236414.1">
        <property type="nucleotide sequence ID" value="XM_016380587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BB18"/>
    <dbReference type="STRING" id="91928.A0A0D2BB18"/>
    <dbReference type="GeneID" id="27333332"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06249"/>
    <dbReference type="HOGENOM" id="CLU_008057_0_0_1"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11399">
        <property type="entry name" value="bHLHzip_scHMS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019006">
        <property type="entry name" value="Sre1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF4">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09427">
        <property type="entry name" value="DUF2014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="133"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="844" mass="94111" checksum="A96EB77B266BCB4E" modified="2015-04-29" version="1">MDPQLDLNSAGRDFDNWLDWNAASTSAGTATESKSTVNPEQVFQFPISPSSTINGDAHHSLKADPLTAHPKHDLLTPQHSSSSPESHSSLDLRLSGDTLREQTSPNERPMLKRKLSPSDVPTTDHRNEVNPTAKKRPHNVIEKRYRANLNEKISELRDSVPSLRIITKKTTDGSNADSDDEDLEGLAPSNKLNKASILTKAVEYIRHLEFRTKRLEEENKSLKERLETLDKVIAQGGHDAQRAAAFTSDTVIEESQATSQVEFPSETRASSSKPPQGLIPVPDSWRKLRQNQSQEHYGHVYDTDRSKYRGKWPTRIMLGSLAGLMIMDGLSESDTGTESREKGLFGIPLELLDGWKFLQSPKIYLAAFTQFCQAGGVIPLIKGFMALTILAFLVFSYLFNSKPAPKEDIEEASSATRFAPAPASPIQVRRRAWSTSMQELHLPHHSFFPEWVAVTSEWLRYTVGYLFGSRAYAWLTGRSAEDDVARIKAWDIAIDAQLAGGDIEVSRSRVVLTIFGSGTLPKTPLRLMLKALHCRVLLWNVGSLGTAPNRIANRVGQFFANWQWTRAQGLHEKLPLRDTDRLPPYLSEMLDLPCNEVFLDTVCQRAYNLMYDRPTQEESSNALMNVVVEDHAIRSPLDAVAAWRSTYSLTQALDAILRCPEPSEMVQKHLTEAMKLAPPGSAAETRALAASSIFSTTARSACFVRASESMDAPPPNAQFERPPYIIDSSTPSSARSDILNCLHCARTLQLLDYEQNEEEARKHFYSKALDSVNVGLLTKASLAYLHQRLPEFQLPGVFAGKDEVRLLPNDPESSADLSAQSKLRRYSSYSNDTGYESQDDSLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BC31</accession>
    <name>A0A0D2BC31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_06236</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236401.1">
        <property type="nucleotide sequence ID" value="XM_016380574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BC31"/>
    <dbReference type="STRING" id="91928.A0A0D2BC31"/>
    <dbReference type="GeneID" id="27333319"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06236"/>
    <dbReference type="HOGENOM" id="CLU_033546_4_0_1"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000001">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="14">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW16185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="341" mass="37080" checksum="C45CB854E62A304F" modified="2015-04-29" version="1">MASNSIKLLTGNSHPELAKAVAKRLGIELTKIMVLQYSNQETSVTIGESVRDEDVFILQSTRPNDINDGLMELLIICNACKTASARRVTAILPNFPYARQDKKDKSRAPITAKLMANMLQTAGCNHIITMDLHASQIQGFFNVPVDNLYAEPNSTKWVRENLMHATEDNAHINGAKEDCVIVSPDAGGAKRATSIADKLDLPFALIHKERSRPNEVSRMTLVGNVSGKIAILVDDMADTCGTLAKAADTLIKHGARDVVALVTHGILSGKAVEILQTSQLSRLVITNTVPVPEEKVEALKVEDGQKGCRLEFIDIAPVLAEAIRRTHNGESVSYLFSHPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDL1</accession>
    <name>A0A0D2BDL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_04189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lipid hydrolase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237214.1">
        <property type="nucleotide sequence ID" value="XM_016378537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDL1"/>
    <dbReference type="STRING" id="91928.A0A0D2BDL1"/>
    <dbReference type="GeneID" id="27331272"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04189"/>
    <dbReference type="HOGENOM" id="CLU_009031_2_2_1"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 6 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="9">
        <location>
            <begin position="280"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="644"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="6">
        <location>
            <begin position="311"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW16998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="707" mass="80876" checksum="E302A9DDDDC4B4F2" modified="2015-04-29" version="1">MNGKTESNPATGNGSYDPSALPDYDNDFIAREDLEAFAHALTAPTTEPLVALNDWGPIRQRVKRTRVRRKPPRRSKDETREGFVYSLLYYPLLFVVCAWIVFLFIIYNLTRFYIFAYEHLFTWTGRRETLRRQLQQANTYDEWKSAADQLDKYLGNEEWKQQDQYSYYNHQTVRKVTAQLIELRQKAETEADNGRVGFRVSPALDELKALLESCVKNNFVGIENPRLYSETYLGTKVLIQSFVDEVERSLKLVLHSEELTDHDKAVFFRHLELNYGRTALCLSGGATFAYYHFGVIKALLDAGQLPEIITGTSGGALVAALVATRTDDELKELLVPALAHRIRACHEGFATWIRRWWRTGARFDSVDWAKQCSWFCRGSLTFKEAFQRTGRILNVSCVPSDPHSPTILNNHITSPDCVIWSAVLASAAVPGILNPIVLMRKTRDGQLVPYSFGNKWKDGSLRTDIPLKALNLHFNVNFSIVSQVNPHINLFFFSPRGSPGNPVTHRKGRGWRGGFLGSTIETSVKLDLQKYMKILRHLELLPRPMGQDWSEIWLQRFSGTVTIWPKTIVSDYWNILSDPSPQRLDRMIRVGQRSCFPRIRFISNRMKIERVILEGLRRGGPIDDSHRVPDPVHEQQAQEALLHGRRKPDSLRPDGYGDEIEGRTPRRQSSILAELTRQASVLWQGEGHTEGEEDAIDSPYEAEEEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDR2</accession>
    <name>A0A0D2BDR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="5">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_04274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="5"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237299.1">
        <property type="nucleotide sequence ID" value="XM_016378622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDR2"/>
    <dbReference type="STRING" id="91928.A0A0D2BDR2"/>
    <dbReference type="GeneID" id="27331357"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04274"/>
    <dbReference type="HOGENOM" id="CLU_005116_1_0_1"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:interstrand cross-link repair"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21315">
        <property type="entry name" value="FAN1_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="7">
        <location>
            <begin position="812"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="670"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="892"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="686"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1008" mass="114401" checksum="F4142CDED5DB3608" modified="2015-04-29" version="1">MPMAPGPQSPSIHNSLMGTRIPHPASTRWDDEDDDFPLRPTKRNKIAPSSPKRISPRKPLPKQRTRNEIPDSEDEEQDLEEDGGVRLPADFRATQLEATLPPVQTDEEAIEAYEAYKASEYVGQQQEEDGESTSVSRLESRRWVRGRSSIYVDAFNLALNTVLEDEGHLFNEAEHSLFKIWQKLDYEAQYLYVRLFLRKTSKWFRVKDLQYYSDVADIDAAVLELQKQRPLPTDEAEPEIYPGELEPDRESVLGQTFAFAECSSAQITTLDEASSLLLLDELKILAKEAKVQGKNKRELLQNFRRTSGKQTGLGFKELRRTDTEESATSVMSEDSQSLYDDDEDGQTSGSRTPTINNRDAHFTKKILRRTGRCIRLSLTPLKLFERVHLVFYRSTEWTEKSLTTLILAKISRRNFPEYIVSRSATIFESRALLLEFEASLRTQFKVDNILEFNGTPGRKSLEEVQRIFEAVYPRWKFLLAEEERKEERVYESGEGAYLRRFSPAWVYTRIVHKGLQPLARFKEHLREHEILTELLDQRLFHASRRGAWYQRKALLEEHYLHALTPSEGRSPEVNKKHWKRIALSTCEQGLQDKECHIIYHYDLQKRVKKLEKQLRIPVREQHDFGHVRLAKPFERDVVGVKLEKDDVEPWRSLSGISNRKSSVTSLVADVHSNDEKAGEDGEEKTTNTSVRVSASKTPSSTVLVRHPSTGSGGGSAPGAKTIWLDTLDTNEPVSVEAMCLSHYRKVLGYKGYHSEGGILRTIFGLLFYDILFFNPYIPNVFQTAYQTCPLDLHTDSFFSSRVPEILGRINQISNGEAEDIVRRVWDDNFERRTCIVGVRWDGFERDDLMECVSCWDNQGLATVMLVMAQEYQSRGGGVPDLVLWKVVDGNSGSGSDADSDARHRRQTSPTGPSGAGTGFGDAEDERSESVSVPVATSENSEARGATSKGKRRGGEVIFVEVKSANDRLSDTQRLWISVLLGAGVKVELCHAVAGEVRPTPQLSTTTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEK3</accession>
    <name>A0A0D2BEK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="91928.A0A0D2BEK3"/>
    <dbReference type="GeneID" id="27339003"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11920"/>
    <dbReference type="HOGENOM" id="CLU_032690_3_2_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="52"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW09819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="225" mass="25162" checksum="A9B88CE4EDEA40A9" modified="2015-04-29" version="1">MASEKGASDLHGPEHLPWPFRFQRQTESVPTDLGPENGFMPKGSPIESRGHTITNEAEPWRRHAQQWIRTRGTISASGGHQAQAVALAYLSDSYLLGTISRVNHLYRFRGVEATKSASSKPSSADEDSEGESVERLKEIEGFRDDPDNRNGRPEVDMTVSLSHSIYFHRPKDVRADQWLYFDMSSPWSGDERGLAVLRIVSREGVQLGTCIQEGLVRLTQSVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BER9</accession>
    <name>A0A0D2BER9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237674.1">
        <property type="nucleotide sequence ID" value="XM_016378997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BER9"/>
    <dbReference type="GeneID" id="27331735"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04652"/>
    <dbReference type="HOGENOM" id="CLU_114180_0_0_1"/>
    <dbReference type="OrthoDB" id="4120715at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="189" mass="21228" checksum="DA19A29F591E2ECB" modified="2015-04-29" version="1">MPPKRPSRKATRAQPASSRRRRNDAAADDDGANDAPIDDDINMDDDDDGDGDGESATESANDLRSVEESLKISMVVDTGLRKEQRQRRLETEFEGQVRLVEEQVENRGEERKREVAQWQSDVLARLLALSRRKSDLETQIFKETQELADAYLALKEEFEAVLQGREGDVNEAIDSLNKLEEAAPPKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEW0</accession>
    <name>A0A0D2BEW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_04351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237376.1">
        <property type="nucleotide sequence ID" value="XM_016378699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEW0"/>
    <dbReference type="GeneID" id="27331434"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04351"/>
    <dbReference type="HOGENOM" id="CLU_061199_3_0_1"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW17160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="31195" checksum="EF179F273CA4C15B" modified="2015-04-29" version="1">MARALPPTPKPQTPMDFPGPLQVIAAGLPRCATSTLKEVFEDHLSIGPTMHMNRCPPQPATMKLVHDALREQDTTKRRTILYKLFQGCAATADFPGHLFIEDLVEMYPDAKVILNVRKGGATDWGSSMKTTIAPFMSWSYRVACYWSVPDWWHYQTERAWEEDVRERFGVGHFWDSAVYDMHNEWVKRICREHGREVLLWEPGMGWEELCGFLDREVPVVPLPRNNDRKKMEDVVKWRIALGWKLWARKAAITVLATVFGSWGLKRISGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGN5</accession>
    <name>A0A0D2BGN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein Dnt1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238011.1">
        <property type="nucleotide sequence ID" value="XM_016379334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGN5"/>
    <dbReference type="STRING" id="91928.A0A0D2BGN5"/>
    <dbReference type="GeneID" id="27332073"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04990"/>
    <dbReference type="HOGENOM" id="CLU_279398_0_0_1"/>
    <dbReference type="OrthoDB" id="4120314at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="880"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="983" mass="105870" checksum="FF4F9AACAF2C7CDC" modified="2015-04-29" version="1">MVKLRVAVRVISEDQYLKHADRPAHLAIEGEKRLLVVVREPERWQIGTLALEVQRAYKSCYQHDLPTIKYLKDDEDDYDLDPQLYVSDLLVDEGKAARDGADQRATIKVILEQGRAVREGSVAIGSQLDDPQYQRQLHKTSRPPVPTFSGVTSSLGKHSLPVDDNVARTNGAKRPRQVEALGSIREESLVSSIERDVSPGLAEVTQNQEMHPDPKHESPELFRHMQAIPAATLDELEELPEQPHDFAPHNERRRDSSGRGVGGVLQEITKVFSPLATSRQSHAQSQGPITPPTDVPSRQSSSSRIQPRTATSGQGSASASKFKRNNIYDFPASDIDDSQMSPRSRQGQLGQPRTSDRLSHIERLGTPNDNDDDPERRLSTQEAYDALETESLLDDNGMPDRNALRIGQDTEGPVQSEGTDYAIYEDEAVNGDPAIPDPSATEHPDADKENSAVSVVHAHPDREASAPQEWPNEHPEPTTRVNEISAMAATNKATEIDNDNDQTQQKTQTRTARGSTSNISSASSNDDLENIKTRKALRPSAKVTTKLPAQTKVNGRKRERSGTPSLDSPGEQLFQTLEESEKRPEPTSSAKPKGTKQKAAARQTSNSAAKKKSLSGGNVSQATVDIATTKDPVLEGKHAAERAAVVGNVEVNATQPRVPAKPLPSWGSGSTTSRKQAAKDLDQTKSLSTTHPSSEPKKSPSVSYSYTEEEKRIMESRAGMTEEERAARKSAAATKVKPSQVRKETPGKSSSAAIKSITPHRETSVSTSSKGKQSDTAVAPKTPSAKTSSVKSTVTNTASKQRSASSAPSTGPKPVASTKKSSTISKTPVASAKANIQPQATPKPNPTLTSVQPKAPTITSAKRLTDLRAALRNVDHMANSTATSTSLSRASSRAPLGRSALATSDSDESESDSDSESDSDSDSGSDRGKTAAQKPTSSVSLGNKQVNGSASKKVLGRPDPSIRDRSVDSDDASDDDDEDDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGR8</accession>
    <name>A0A0D2BGR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LYR motif-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238041.1">
        <property type="nucleotide sequence ID" value="XM_016379364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGR8"/>
    <dbReference type="STRING" id="91928.A0A0D2BGR8"/>
    <dbReference type="GeneID" id="27332103"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05020"/>
    <dbReference type="HOGENOM" id="CLU_151409_0_1_1"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20262">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045293">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF0">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="8">
        <location>
            <begin position="36"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="105" mass="12361" checksum="1201CD9A200A3427" modified="2015-04-29" version="1">MRPSLRLLASPAATATPRPRTKKPPPLSFDHFIQRQRVLGLWRTILRKLYKIPQDRRAEPVSYARGEFERNKHVKDISQIRYLISTGKAEFDGMQRYIDELASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGV3</accession>
    <name>A0A0D2BGV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230770.1">
        <property type="nucleotide sequence ID" value="XM_016385826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGV3"/>
    <dbReference type="STRING" id="91928.A0A0D2BGV3"/>
    <dbReference type="GeneID" id="27338601"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11518"/>
    <dbReference type="HOGENOM" id="CLU_281871_0_0_1"/>
    <dbReference type="OrthoDB" id="5341924at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="899"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1098" mass="122616" checksum="D27B6C36DA24B513" modified="2015-04-29" version="1">MRRCFEQSRFRRHLHCFAHRSVYPPKPVPHYQTFPPSNTTSLYNVSTLVTRPLSTVRRPKQITLSASQSDPRFQFAKTQRHISGHKRGGQTRVTKAQKKKPEYWIALLDGFLPKDLSLSFRNDARTDFDERKDFENVFKILQDAKSFAGLDLLAFMALGQGRHKAVVYLAEILLKPAKSLPGASLEQTLPSNIAWPQFSFSKLVKQPIELDAERHVKRQSVSNALPNQDSNACETGYERVMPLLWQSLAELVIASIRRPQKEGKLIIQTVLIILAKIHHVDLIPSAVYTYAVPKAPTNIQHSPILSLLNSRILSTLSDAVWQAQQEDELAKAATGDASRHDLTYDEVLPGGRFRLELRELGPEVWVEFILWCCVEGGYPSAGARIIRALRADTEYPWSAVHWTTSGQNAENPVPSIDWDRVRRRPGGSVGGFEAYSREDPFVQMQPRTISTEVVLALVDCLINSVDSVSLRSTTGIGSKIWDVLSFLEPHGLAPSYFDYLAVRLLQTENFGLRTGPHGLENWALTVSHLRSLRPVKVRSFQKPSLTYDYILKHTMFQAGFWHQVLQAYIESHRATKAVEVLTRIQQLVDTSKLEAIGEFMSGVVRPQDGFFTSRPSKRHTEYIDSHGQLPEYKLLLVINLVTSAKLFGLSDWLLHSSDVDGPLIPVEVRGRPSIASGLSRHAIAKDDLFLLRSVVEQSARSDRKPTVNLLRALANAQIHFRAWGDVSFLLQQLKGSETGGYSPSIIANLAASILRLEVESKIQQRDGAVQDHQQAEKLLIDILSGRYNAPSSDFTVLQRKFFRQQVNSLLHVLQAIPDSSLEDVAAQYLAKYPVSNLPQLDRATFNVIFSAIVEVKGALEGRRIWEMFCTPNGWVSSSDYNSTDEVETTDAEGRHDVSDGSTSDLSTTSPTDDWSGAPLAVSDEVLRDNTVKVVSEGQQNAELSLPQSLGLEDDRNDIPFVSSVDTGAAASGLHLQTSPVVVPDLHTLQILVNAALSEKESDFGQRSSETQHTELDDLLAWATAVAKSWGMSSKDIETELNIPAAFHSWILAPYPGLSRKRQAFMDRHGPLDVSSYFMRGLMVPRAPSIKYGSMNSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIJ1</accession>
    <name>A0A0D2BIJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="9">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_03052</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238979.1">
        <property type="nucleotide sequence ID" value="XM_016377409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIJ1"/>
    <dbReference type="STRING" id="91928.A0A0D2BIJ1"/>
    <dbReference type="GeneID" id="27330135"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03052"/>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_1"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="75"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="606"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW18763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="807" mass="86708" checksum="CFA08FD98D92C2A9" modified="2015-04-29" version="1">MSAFLQRRPSLAVRCPLDLGTSIWRRAARRAYAVHAQSQPLPRRKAAVPPYQKILKRFEEVRAILGSRKLTLAEKILYAHLDNPEESLLTNTDNGKNIRGNANLKLKPDRVAMQDASAQMAILQFMTCNLPSTAVPASIHCDHMIVGEKGADTDLPNSIAGNKEVFDFLESAAKRYGIEFWPPGAGIIHQTVLENYAAPGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALVDAPWELKAPKILSVRLEGKLSGWASPKDVILHLAGQITVRGGTGSVIEYTGPGIDTLSCTGMATICNMGAEVGATTSIFPFSENHIPYLQATGRAALVDAIKGIAYGSEQYNFLRADAGAEYDREVTINLSGLEPHINGPFTPDLSTPLSKFKGAVETNKWPSTFSAGLIGSCTNSSYEDMTRAEDLVKQAQAAGLKPKSDFFITPGSEQVRATLEDSKTLQTFEGAGGTVLANACGPCIGQWKRTDGMKKGEDNAIICSYNRNFPGRNDGNPRTMSFLASPEIVTAMSFSGLTSFNPITDEIPLPSGEKFKFEPPKGTALPGSGFAIGNPAFLPSSAEPDSSVQVVVDPESDRLALLEPFEPFPEGELKGLKVLYKVKGQCTTDTISAAGPWLKYKGHLPNIAENTLIGAINAATGETNVAYDVDGSKSSIPELAKKWKQQGQNWLVVAEDNYGEGSAREHAALQPRYLGGQVILAKSFARIHETNLKKQGVVPLTFANKEDYDRIDACDSVDTEGLWDVLRNDGQGEIRLKVTKMNGETFTIPVKHTLSKDQCGFILAGSALNLLAKRNKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ73</accession>
    <name>A0A0D2BJ73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_02919</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238846.1">
        <property type="nucleotide sequence ID" value="XM_016377276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ73"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ73"/>
    <dbReference type="GeneID" id="27330002"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02919"/>
    <dbReference type="HOGENOM" id="CLU_000404_1_2_1"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="791"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="791"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW18630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="882" mass="98736" checksum="010868C7108EB958" modified="2015-04-29" version="1">MFVFKRDGRKERVQFDKITARVSRLCYGLDPEHVDAAAITQKVISGVYQGVTTIELDNLAAETAAYMTVTHPDYAILAARIAVSNLHKQTKKQFSSVISDLYHYVNPKNQKPSPMISKETYECVMKHADELNSAIVYDRDFNYQYFGFKTLERSYLLKIGKQVAERPQHMLMRVSVGIHGDDVEKAIETYNLMSQKCFTHASPTLFNAGTPQPQLSSCFLIDMKEDSIEGIYDTLKTCAMISKTAGGIGLNAHCIRATGSYIAGTNGTSNGLIPMLRVFNNTARYVDQGGNKRPGAFAIYLEPWHADVFDFLNLRKNHGKEEVRARDLFYALWTPDLFMKRVEKNQDWTLFCPHEAPGLADVYGEKFEALYEKYEKEGRGRQTVKAQKLWYAILEAQTETGTPYILYKDACNEKSNQKNLGTIRSSNLCTEIVEFTSPDEVAVCNLASLALPTFVDQSTGEYDFGRLHEVTQVVTRNLNKIIDVNYYPVPEAKKSNMRHRPVGLGVQGLADAFLALRLPFDSPEARQLNIQIFETIYHAALTASCELAKEQGTYETYEGSPVSQGILQYDMWNVTPSDLWDWDSLKAEIAKHGVRNSLLVAPMPTASTSQILGNNECFEPYTSNIYSRRVLAGEFQVVNPWLLKDLVDLGLWSDNMKNRIIAEGGSIQNIPNIPDDIKALYKTVWEISQRTVLQMAADRGAFIDQSQSLNIHLKEPTMGKITSMHFAGWKMGLKTGMYYLRTMAATQPIQFTVDQEQLKVADTNVARERSAPKKRTSLGYGQSYTTSSVRPMYASKNSNSSFHGGATSMNGIPTPTSTPPPTEDKQLASKLARSRLSDGASSGEPSPKDKESDSEEREGDIYAQKVLQCSIENKEACIMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK72</accession>
    <name>A0A0D2BK72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239181.1">
        <property type="nucleotide sequence ID" value="XM_016377611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK72"/>
    <dbReference type="STRING" id="91928.A0A0D2BK72"/>
    <dbReference type="GeneID" id="27330337"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03254"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF127">
        <property type="entry name" value="3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="26854" checksum="28252166AF00FE20" modified="2015-04-29" version="1">MSVDNELKGRVALITGASGGIGSACARDLYRQGCHLALTYSKNKASVDTLLAELQASSSDPRISTHQVDMASAEQMENLYAEIETEHGHGPDILVANAGYGKRIPQIGDITYEEFDYTIQINLRAPFILAKLAVPHMAAQKWGRIIMISSISGYGGGINGCHYASSKAGLMGMVKNLALKLGQDGITVNDVAPAMIGETGMIPNAEFLQGTPGDVRNIPVGRLGTPQECANVVTMLCKTGYLTGQSIILSGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKC8</accession>
    <name>A0A0D2BKC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231955.1">
        <property type="nucleotide sequence ID" value="XM_016383332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKC8"/>
    <dbReference type="STRING" id="91928.A0A0D2BKC8"/>
    <dbReference type="GeneID" id="27336094"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09011"/>
    <dbReference type="HOGENOM" id="CLU_083057_0_0_1"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="197" mass="22510" checksum="54FE503C14AC52A2" modified="2015-04-29" version="1">MQPTLNLDHFLTDDDCDIGDEYASVVDAALDMRRKFSSVLRQARQLKTTLQAKQADLEHERQRLELRTIAETSRNKLRQQSRRLRQCKDDNRSLRLQNQELASRLEVARKELEKVDHLRCTLCTVAFKDAMLPCGHTACRVCLDLWIGQGNDCPWCRRSFEVGDIRDLYLADPSATADALEEDGDVTDVISLASDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKJ2</accession>
    <name>A0A0D2BKJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232010.1">
        <property type="nucleotide sequence ID" value="XM_016383387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKJ2"/>
    <dbReference type="GeneID" id="27336149"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09066"/>
    <dbReference type="HOGENOM" id="CLU_581449_0_0_1"/>
    <dbReference type="OrthoDB" id="5296805at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="470" mass="54035" checksum="C030DE0E743B59E4" modified="2015-04-29" version="1">MSGDTLMGDPDDALFFPDTRRAGEGGGDGGSPFDTDAWDDEVLDVIDKASDTYAANRSIHYYLEYHKQEFLELLERQVNLIKTRSPVLKHNRITVYDKALLNITRSGRDLDQPAAIVVFCEEYLGISIAVKGRASDVTTALGRAMDLRNTLIRDAPDHADSYQRSPDPEPEHPAVIEGGQTHMQVVDTQVTRLWQVYEQAKADFNAVPNREGQEIIDAAKFLRDTAENAIQYLADKDVDPEAMAELQSTCNMAKANVVSLTGGRKRKFDVVDKLEHAPRGPEADVAETPTVSYGPETFEATPNPAAEQAQAYRRRPLDAREDDVNSKRERSEGKDQHHHHDHHYSKSSDSEYGAGARYSSYAGESERGRNRERQRRNRRLYAHSGRGHGDRDRDRSRSRRRKDHTRDASRGKDREYECGRDRDRDRYHRERSDEDGYWRRPETPPWDRHWSRERTHPYRREVDSYKPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLB0</accession>
    <name>A0A0D2BLB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239959.1">
        <property type="nucleotide sequence ID" value="XM_016374683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLB0"/>
    <dbReference type="STRING" id="91928.A0A0D2BLB0"/>
    <dbReference type="GeneID" id="27327400"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00317"/>
    <dbReference type="HOGENOM" id="CLU_096188_0_0_1"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="98"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="196" mass="21313" checksum="EA8EEC4E2D0805D9" modified="2015-04-29" version="1">MASSDPISKHTASSASPLRDTTTYITGHNSKDYTAIYASVRPAAWQAIKDTNHFNVSFTTSEMPVRMDDDADIAKHDEVMSSGSLGLVRPNGTVCRTVDFAPAGEALMHRTKSLDYGIVVEGEIELHLDSGEVRTLKRGDVAVQRGTMHAWKNASPTHWARMIFVLQDSAPVRVGDRVLPEDLGHAKGVIPDSGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLG4</accession>
    <name>A0A0D2BLG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240009.1">
        <property type="nucleotide sequence ID" value="XM_016374733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLG4"/>
    <dbReference type="STRING" id="91928.A0A0D2BLG4"/>
    <dbReference type="GeneID" id="27327451"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00368"/>
    <dbReference type="HOGENOM" id="CLU_014055_1_0_1"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000037">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="451"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="572" mass="61897" checksum="3A1D31252F8F3578" modified="2015-04-29" version="1">MDANAAQRPAQPAPAQQASLIRPEQVQRLPQLNPAQKQQYEQGVKRYWEVLNSTQQGDPKYNEAYQGLVRTSGLLMAGMKQWQTAAKQRQVAQQQASQQAAQQAQAQQQAQQQQQQQQQQAQAQSQGQKQAAQVAQAPNGAVQAGNSSMQFNQLMPEIQKRVNEQNFYYPPAMTKGTEPAENWLREAKARLGQALQRLQVAKQKKAEFQRQAQQRQQAGNPLTPQETEVYNNKIAQCDRAINESGSFMKKFNEQQEQFRSAQPQHQYTKQATAGGEATESGVMPHLQPGVQGPQAHSISSAVSAARNQANTAQATVPAVTTAQAGQITTTASQATPVTATQQQFPPTAPTDGTTAARPVSHQGQPIAPQSATQSAMHPHPLNTSINNAKTPTPVITKNLQVAEPKPVQMPPSRPTMTGGAGVGLPGQLAQPALTALPGYVLESSEDGRVLSKKKLNELVREVCGPGPDEQLDPEAEEIFLQVADDFVDDVVTQACKLAKLRGSPSLELRDIQIVLERQYNIRVPGYSTDEIRTVRRPQAAPGWAHKMSAVQAAKLTTGGSNTATVGAGGKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM79</accession>
    <name>A0A0D2BM79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_00573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240214.1">
        <property type="nucleotide sequence ID" value="XM_016374938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM79"/>
    <dbReference type="STRING" id="91928.A0A0D2BM79"/>
    <dbReference type="GeneID" id="27327656"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00573"/>
    <dbReference type="HOGENOM" id="CLU_1555269_0_0_1"/>
    <dbReference type="OrthoDB" id="4159735at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="49"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="172" mass="19487" checksum="609956BEA1E63935" modified="2015-04-29" version="1">MGLTPCPRTACPLRSMEPADQQFDFDRTPMSWLQQTENTPVQSSKKATVKRSERRREQNRLSQRAYRERKENHVKSLESQLQSLCESHEILVQSYRGQAREVGQLEGRLARLKAELQTLRASHVRPLAEFCCSRAVINLVELSVSGPIPGCSTGYADHSPVNPDTECFSPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMU8</accession>
    <name>A0A0D2BMU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240101.1">
        <property type="nucleotide sequence ID" value="XM_016374825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMU8"/>
    <dbReference type="GeneID" id="27327543"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00460"/>
    <dbReference type="HOGENOM" id="CLU_122943_0_0_1"/>
    <dbReference type="OrthoDB" id="4161095at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="151" mass="16018" checksum="D4D9A39D6B2043B7" modified="2015-04-29" version="1">MSANYSYSSSSFVSATYSSSGTASSSSDAARGNNGHNQAHSQRYTETVTSNDRDGTTVYRTHEETGKPILAEAYHAPATSTGAGPGQGRGVTRGIADGGGVSSDGTHAQNRIQDVTDDDDDDAAVDPEQEERDRQYLERMEDEYAKREGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNN4</accession>
    <name>A0A0D2BNN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxisomal membrane protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240361.1">
        <property type="nucleotide sequence ID" value="XM_016375085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNN4"/>
    <dbReference type="STRING" id="91928.A0A0D2BNN4"/>
    <dbReference type="GeneID" id="27327803"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00720"/>
    <dbReference type="HOGENOM" id="CLU_054132_1_0_1"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW20145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25439" checksum="AA1592840323FD7C" modified="2015-04-29" version="1">MDVLKDTAESIILNPDLAPLLAILKAARNGAVYGAKVRFPHALVMVFLFRSGSIREKTRLVLKATKQHAKNLASFAVVYKSAMLVLRLLNPTNPGKEGPYDTFFAGLLGGYTVFGRAKQGSVNQQIVIYVFARVMLALARLSIEAPAMTSTTPTPTLWTQRLSPETKAMVQRNAWPVFASFSWAFVMYIFRWQPESIQPSLRSSMKYIYVNSDYWDSLKNFLIYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNV4</accession>
    <name>A0A0D2BNV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor cwc2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PV08_01158</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240799.1">
        <property type="nucleotide sequence ID" value="XM_016375523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNV4"/>
    <dbReference type="STRING" id="91928.A0A0D2BNV4"/>
    <dbReference type="GeneID" id="27328241"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01158"/>
    <dbReference type="HOGENOM" id="CLU_043308_1_0_1"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="188"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KIW20583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="418" mass="45872" checksum="AAE7333ACE420238" modified="2015-04-29" version="1">MAEVVQARTSFAPSSPSRKRSASPDAGDSAATTALTTTNNDTTLASSEPPTKKTKLIRRKRRPARPQVDPSTIKSEPPPQTGTIFNIWYNKWSGGDREDAYLSKTAAPSRCNIRNDSGWTAADKTPGSYFCLFFARGLCPKGHECQYLHRLPTIYDVFNPNIDCFGRDKHSDYRDDMGGVGSFMRQNRTLYVGRIHVTDDIEEVVARHFQEWGEIERIRVLTGRGVAFVTYVNEANSQFAKEAMAHQALDNNEILNVRWATVDPNPLSQKREAARIEEQAAEAVRRALGERAVREIEGRETKEEREQRRIESGFGLDGYEAPEEIWYNQQKQLEDTGKGLLEAPPQNTNQAPGSETTQNTAGGDGDSSSGGGGGIFSGSTLAALQRKMATVRPLPAQAAKPAATAGPLVGYGSDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNZ7</accession>
    <name>A0A0D2BNZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_00830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240471.1">
        <property type="nucleotide sequence ID" value="XM_016375195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNZ7"/>
    <dbReference type="STRING" id="91928.A0A0D2BNZ7"/>
    <dbReference type="GeneID" id="27327913"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00830"/>
    <dbReference type="HOGENOM" id="CLU_055156_0_2_1"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="94"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW20255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="253" mass="29560" checksum="890D60080EEA2180" modified="2015-04-29" version="1">MTKPVVKSTVPTQDQVLVPETLLKKRKSQEKAREQRIAEIEKRKKTNKEKRGVIFKRAEQYVKEYRDAEREKVRLARLSKQKGNFFVEEQPKLVFVVRIKGINKIAPKPRKILQLLRLLQINNGVFIKLTKATQEMLTIVNPYIAYGYPNLKTVRELIYKRGYGKIDKQRIALTDNQLIEDNLGKYGIVCMEDLIHEIFTVGPNFKQASNFLWPFKLSNPNGGFRTRKFKHYIEGGDLGNREENINALIRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPF5</accession>
    <name>A0A0D2BPF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="16">ATP-PFK</shortName>
            <shortName evidence="16">Phosphofructokinase</shortName>
            <ecNumber evidence="16">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PV08_01401</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16 17">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="16">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16 17">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="16"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241039.1">
        <property type="nucleotide sequence ID" value="XM_016375763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPF5"/>
    <dbReference type="STRING" id="91928.A0A0D2BPF5"/>
    <dbReference type="GeneID" id="27328484"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01401"/>
    <dbReference type="HOGENOM" id="CLU_011053_0_0_1"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000010">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 16 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="18">
        <location>
            <begin position="13"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="18">
        <location>
            <begin position="401"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="16">
        <location>
            <begin position="1"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="16">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="16">
        <location>
            <begin position="401"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="114"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="197"/>
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        <ligand>
            <name>substrate</name>
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        </ligand>
    </feature>
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        <location>
            <begin position="204"/>
            <end position="206"/>
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        <ligand>
            <name>substrate</name>
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        <location>
            <position position="260"/>
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            <name>substrate</name>
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        </ligand>
    </feature>
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        <location>
            <position position="288"/>
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        <ligand>
            <name>substrate</name>
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        </ligand>
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        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
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        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
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        <location>
            <begin position="534"/>
            <end position="538"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="579"/>
            <end position="581"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="639"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="665"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        </ligand>
    </feature>
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        <location>
            <begin position="671"/>
            <end position="674"/>
        </location>
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            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        </ligand>
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        <location>
            <position position="747"/>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00365"/>
        </source>
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            <dbReference type="EMBL" id="KIW20823.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
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    <sequence length="794" mass="87101" checksum="D08DB5648E066BA4" modified="2015-04-29" version="1">MAEADKAPARKRRIGVMTSGGDSPGMNGAVRAVVRMSIHMGCEAYAVYEGYEGLVQGGDLIKEMKWDDVRGWLSRGGTLIGTARCMPFKERWGRLKAAKNMILRGIDALVICGGDGSLTGADLFRSEWPGLIKELVDTNELTQEQIEPYKHLNIVGLVGSIDNDMSGTDATIGCYSSLERICSAVDDVFDTAASHQRGFVIEVMGRHCGWLALMASIATGADFVFIPEKPPRVGWEEQMCDIIKKHRSRGKRRSIVIIAEGAHDENLKKITANHVKDLLSHRLNLDTRVTVLGHTQRGGQACFYDRWLSTLQGVEAVNAVLEATPETPTPVITIRENKIERSNLMEAVALTKSVTAAIEAKDFDKAMQLRDVEFKEYYNSYMITTSTDHPKLRLPEDKRLRVAIIHVGAPAGGMNPATRAAVAYCLTRGHTPIAIHNGFSGLQRHHADKPLGSVRECKWIDVDPWVNEGGSEIGTNRGLPSADMKTTAECFQKYQFDAMLLIGGFEAFTAASELRKARNEYPAFKIPLVVLPATVSNNVPGTEYSLGSDTCLNTLINFCDAIRQSASSSRRRVFVIETQGGRSGYLATMAGLSVGALAVYIPEEGINIHMIARDIEFLRENFANDQGASRAGKIILRNEKASQTYTTQMIADMIKEEAKGRFESRAAVPGHYQQGGKPSPMDRIRALRMAIKCMQHIEDRFTGKSKAAISDDPLSVTVIGIQGSEVVFTPLGGETGLEANGTDWADRRPKNEFWMPMRDTVDILSGRPKLGDCCDECGKPLSGNVLKNLSLAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPJ9</accession>
    <name>A0A0D2BPJ9_9EURO</name>
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        <recommendedName>
            <fullName evidence="5">Maintenance of ploidy protein mob1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01025</name>
    </gene>
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        <name type="scientific">Exophiala spinifera</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016375390.1"/>
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    <dbReference type="GeneID" id="27328108"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01025"/>
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    <dbReference type="OrthoDB" id="8170117at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33247" checksum="2CF27580130DCD07" modified="2015-04-29" version="1">MASLLTTMYEFLKSSPSYPPQPLNPHLTFKQSSSCITVNTFTCYDSEPNSVCSSPSTPSRAAKLLRQGLTSSPASHIDSPSSNARTRGQFKPQRTNKGTTSYQLRQFAEATLGSGSLRKAVKLPEGEDLNEWLAVNVVDFYNQINLLYGSITEFCSPQSCPEMKATDEFEYLWQDAATGYPKPTKMAAPEYIEHLMTWVQSNVDNESTFPSRIGVPFPKHFPSTVRQLFKRLYRVYAHIYCHHYQVIVHLGLEPHLNTSFKHYVLFIDEHGLEKGGGKDYWGPLGDLVESMLKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPX0</accession>
    <name>A0A0D2BPX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_08356</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016382682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPX0"/>
    <dbReference type="STRING" id="91928.A0A0D2BPX0"/>
    <dbReference type="GeneID" id="27335439"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08356"/>
    <dbReference type="HOGENOM" id="CLU_000315_3_2_1"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="SNF2-like_sf"/>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
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        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
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        <property type="entry name" value="Helicase_C"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="309"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="731"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="850"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="97"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="802"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1028"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="804"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1028"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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            <dbReference type="ARBA" id="ARBA00022806"/>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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            <dbReference type="PROSITE" id="PS51194"/>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW13169.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1052" mass="118613" checksum="7EFD7AC91425C123" modified="2015-04-29" version="1">MASEDIGDDMAAGDVAALAAFRANHPSSDSKPVNLKPVNVESVNWDAELVEDSKTAIKENETRKATFARLQEEFESRQAQGITTEEDEILYATAKSAEEQRIKDFERSQIEIEEPVKVPDQPSEEDENSLFIPEVPERPEPPQNSKKATPKPKNRLTAKDKDEAISAGLTRLGTGKPKRKKTQDKGQEPRKRQRTKSTPKRRRPALSNLQSLGSTNIIGPAQANAERPDMPTFSSKDKSKALKELIASIPNSEQRLHSSEKNAILEASKKFNGHGAIRSDGQGGWKLRGMESSLYHHQLLGAAFLRDRERSKTRPHGGLVCDEMGFGKTIQMIANILDGKPEEGSAVKTTLIVAPPALINQWMVEMDKHVKPRALGRILRYHNGSRLMSNDVVADLSSYDIVLTTYSEVQKSYPMIDPPKHLSSEAKKNEWWRDFYVNNCGPLHKMKFHRIVLDEAHAIKNHNSKTSIAVRGLTGNFRWAITGTPILNYIEELFPYFSFLRVPHTGDYTTFCHNYCNNRSNREPVNMARIHNILRSIMLRRTHVDSLFDAPIVKLPGISHTTHEVEFNSVERAIYSMVKRRYAQQINTFSSSGNLTANYSNILSMILRLRMLCSHIFLCQDTLKEMFVAADIENLWQLTQKEVETVDQGTHRTSETIIALRKMLQQKDKTITTCQTRHDDVSTSTDALEIENAESAISTGASFGLTFKFRRFLRELSESNTWVELHARSKCAKCQSLPDEPMCTSCFHVYCQECLAQLRLEKGEGPKVACLECGTLFEETSPCSGLKELGFNLAPVAERAERLKGKRQTAAKGRRSTSRGRNSPDEDDQGKEPSDWIEFGQVLPSAKLTATKAAILNWREKNKSEKIIIYTQFLGLCRILARICETEEWGYVNFNGKMTLDAREKAIENFRDKPEICIMICSLRAGGIGLNLTMASKVIILDLWFNSSVEAQAYCRAFRIGQQNKVEVLRFVVKNSIDEDLVNMQERKDIEVSGAIGPDSLSKRATVHQLLELFGSVKEGEGQNEFILVEDEEEDDDDDGTDVTKRLPPRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRN6</accession>
    <name>A0A0D2BRN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_01629</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241266.1">
        <property type="nucleotide sequence ID" value="XM_016375990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRN6"/>
    <dbReference type="STRING" id="91928.A0A0D2BRN6"/>
    <dbReference type="GeneID" id="27328712"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01629"/>
    <dbReference type="HOGENOM" id="CLU_017054_6_0_1"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
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        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="9"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="390"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW21050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="593" mass="62717" checksum="4E9C24499E4D43DB" modified="2015-04-29" version="1">MQTKHFINDPTHLVQTALSSLTLTNPSLAFDSLNKVIYRRPTKESEENPKVSIITGGGSGHEPAFAAFCGKGFVTAGVAGTIFASPNTLQVQRAIMSRVETRKGVLVITFNYTGDVLNFGLAAEKAKAAGIDTEFFAIGDDVGVGRDKGGKVGRRGIGGSILVLKIICALAEAGGSLKEVYNLAKQVADNLVSVGSSMEHVHVPGREIPAPDSDEMIPNDEIEVGMGIHNEPGSRRVTATLPELVKIMLAQMLDPNDKDRHFAHITKDDKVVLLINNLGGVSNLEMGGIVAEVYKQLKEDWGITPVRVISGTFITSLNGMGFSASILKLEDTGLGAGKSMLELLDAPAEALGWSAPINTETWNAKNDSTMEHHADSSRDLKASNLSINPERSFSLLKAGLDKMIAAEPEVTRYDTIVGDGDCGTGLKRGSEEVLKALSSGELPSDAVSFVNKIVPVVEHHMDGTSGALFSIYLNALVHGLREQDSGSAKQMDAKTWAAALKSALTALGKYTPAVPGDRTIMDALVPFVDTLASTADVKKAAEAAREGAEKTKAMKASLGRAVYVGGESEWMGKIPDPGAWGLSELLVGLADAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRW5</accession>
    <name>A0A0D2BRW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_01735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241371.1">
        <property type="nucleotide sequence ID" value="XM_016376095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRW5"/>
    <dbReference type="GeneID" id="27328818"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01735"/>
    <dbReference type="HOGENOM" id="CLU_055491_1_1_1"/>
    <dbReference type="OrthoDB" id="5290969at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF3">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW21155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="148" mass="15935" checksum="F6CFC0D9D381D630" modified="2015-04-29" version="1">MQGRCQCDAVRFTTPVPNPFKWFVCHCLECRRQSSSAFGISAIFPAFDIRAAATKGGDEIGVFTHSNTASGNTKTCYFCKRCGTRFMHHGHGGANVAVKGGCLDDVDGDCLASATHIWTKRALMPIPEGAESWPEDAPEPEPKSDAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BS91</accession>
    <name>A0A0D2BS91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_06860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234295.1">
        <property type="nucleotide sequence ID" value="XM_016381193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BS91"/>
    <dbReference type="STRING" id="91928.A0A0D2BS91"/>
    <dbReference type="GeneID" id="27333943"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06860"/>
    <dbReference type="HOGENOM" id="CLU_013394_1_0_1"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000182">
        <property type="entry name" value="Outward-rectifier potassium channel TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF342">
        <property type="entry name" value="OUTWARD-RECTIFIER POTASSIUM CHANNEL TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="258"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="522"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="796"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="853"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW14079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="909" mass="102461" checksum="1F8A0777FEF98AB3" modified="2015-04-29" version="1">MGYDHAEQREVHPPGTDSSTGSAGTANASDNSLSKEWDGPRESNQSVASEGNNDGAGERKRHHRRHLEAPKLRLRAADDDLPTDWWFASTAIPLLAATFAPMANMISIEALVVAWRNNVVDPDDPIYYQATSVGYPDPAWCINLNIASLVCGFVGNLFLLLNFTKRVRYIVALPATIILFYVSAAILIGITVSMHVYVPPGQDQVYSQGFWNAVIAACLYMFNSMILMVNMGGYFLGHYPQHFTLTDEQRNLILQTMMFFIWLAGGGGVFSRIEGWGYPDAVYFCDVTILTVGFGDYYPTSNLGRGLVFPFSVGGIIILGLMVSSISKFAGELSTVNVLRKHVENRRLNTLSRVVTVETAEEDNRRQDLEKKVEIELNHGRKLSISAPIPDPRIERNLDREAHGGLETGLSTGRDNDQDQQITARQIGFEDTTAETLKQADESLPHPRQFLKHDFHKGPVHATLKLLAKPVNDLRRVRTRGHKVILMREERDKFNAMRDIQEDAKKFKQWFALFVSTIAFGVLWCIGAVVFWQAEQNTQGLTYFEALYFCYVSLLTIGYGDLSPKSNAGKPFFVVWSLIAVPTMTILVSDMGDTVISSFKRGTFLLGDMTVLPKKGFWHDRINSNPWLYQWMSKRVEKRRRKKGLPVGPDETDASPIVSIEELAAEELNETELTQRLAWAIRKTADDLQHAPRKRYSYEEWAEFTRLIRFTRNGLEQLQFDEETDGVVDWDWLEESSPMLSGQTESEWILDRLCESLLRLLKRHMMGFDTALSRSATDLTTYSLSRQVTRQELGDAIKSKQDKGKAVQPSPPSKRQERRRRASGADAVLAFLTGPREGERARETEAPQWSSRAKTKAEKRRAKDAHKKRRGPFSKLESRVTGTVGGGRGGAGMRTLKKRHMDFDADSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSW7</accession>
    <name>A0A0D2BSW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall proline rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234590.1">
        <property type="nucleotide sequence ID" value="XM_016381488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSW7"/>
    <dbReference type="STRING" id="91928.A0A0D2BSW7"/>
    <dbReference type="GeneID" id="27334239"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07156"/>
    <dbReference type="HOGENOM" id="CLU_007264_0_0_1"/>
    <dbReference type="OrthoDB" id="5406427at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="892" mass="95653" checksum="5C67C2975D243E72" modified="2015-04-29" version="1">MTSISLPPTVPGLSLFGPEPESPTRSPAAHRRRPSRNPNAAQLPSFSFNPGADDTMNAGEMGRRNLRGGIATVEAGQRPSRPALPDFKFNPGADLPPERSPSPTHPVLQEMALNQQRAVRSARPAPLPAFTFNPSAHPAQASPSPTKLSPGHVQPPSHRSGHRRGVSEFVGGGNNGPQLVSTSPEKPEYRPHPPVTATRGHAHRRSQAVSISDIDTSELIKANALSKARAGPPPTSPSESALAFSYPRAGPSLRQSMSNIVRTPPSSPRRRDSAPGVRPRVGFSDQVDVIPRPLSLISSETEGSNSTIRGCHSLSGSINSIASPTPRPAVVITSGEIWSSPERPQTADAQSTLSPGMASATQPISLINLPKRPLSASGSPGTLSCSSPPSKKKYFWFNQSTMSSPSTTPRTEHSDPMDVFSSDMCPQPSVLRAFADQGRPKTSAGEPGSSSSRKRKYHTWTSGIFSRKTDSKRSSKAKETEVPPVPALVRRPSDRLKDIFDADDTIILREPSPVATRVRPPMPHPVPAQASIPDEPAEHITSPVLDLDAALGPFGSEEKLSPGRNNPLDRMAKLHSSERRGNVDAFGSVHRRTESAPTMPAVNRTTFGVHRMGSNSSLTEDVFDEEEEDNFLAGENIESQSHLPADNQSDPMSIDALGTSPPARFNGPSLKPTEGLGLSLGKNRADGVIIADLEEDVARAEARSSNSTIEAPVFPDFETQKPSTSPMVLAYPAPQSYYASSTEGRTTSASMISSPDADHISFETMARPNRTVGEASPDFVLRASIDDLPSLSDSLSSGVLPRFSSSAGTRSSTDQRSHSMIDPSTSRSHSQQAWKRASLASLNRLIPSSSNGSKLKFETVPDPLVGDVKVRKKNNRISKLVNFWRSKDKPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BV61</accession>
    <name>A0A0D2BV61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235350.1">
        <property type="nucleotide sequence ID" value="XM_016379523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BV61"/>
    <dbReference type="STRING" id="91928.A0A0D2BV61"/>
    <dbReference type="GeneID" id="27332262"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05179"/>
    <dbReference type="HOGENOM" id="CLU_008719_5_0_1"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF24">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="53205" checksum="CC8192F7A14A2694" modified="2015-04-29" version="1">MDLDTANTFVSPGALSGESAFDEYASNPRFQQLQTELRSWLFVGANSRDHSPEPELTPEEHNLSASYRPGHEYLWEHMVNGASQIPPFKKIHYLQVWITDCAPWLDMFDGERHFGQQVPIIAQRSAAVLHAMLAVGARTAERQARIELSGSHDSLELYSQAITSLTSSLSTREPTVVLTACLLCVLEMMSVSPRDWRRHVEGCAALFASFGINGFSGGLLQAVFWCYARMDLCGAIIANGTEATVLGIDKWIRLEEFSGSDVEKGEEINRRFWLKGQQVPDMYANFAVYLCAKVCDLLVRRIKCVEMGEDNGCEHGNLESEWTQLWGDLQEWLSRRPVEMLPVKTIRDGAFPRIFFSHWAAISGNQLFHTACILMLEIKGIQELDRPEQVYSPLWHARRIVGISLTNPHPGCINNAIQPLYVAGKLFTHREEQAIIVKLIDSIETRTGWGSRWRIKDLEAFWGYHRGTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVB6</accession>
    <name>A0A0D2BVB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_05254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235425.1">
        <property type="nucleotide sequence ID" value="XM_016379598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVB6"/>
    <dbReference type="STRING" id="91928.A0A0D2BVB6"/>
    <dbReference type="GeneID" id="27332337"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05254"/>
    <dbReference type="HOGENOM" id="CLU_060351_1_0_1"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW15209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28589" checksum="E7C04D9592B141D0" modified="2015-04-29" version="1">MIPVPHPASPEFEKLPPWARKLLNRPLVEIRRGLSLDYDPPTENHSVLVLTAPSGKYVDIRFASASKDKYEGIKESDAFNGYATAGLSTAWLPGGTDSCPEYDCVAHVKWEHPIDSSREYGSDGADMYLLSNGDVMEVGFLTVKGKKKMFKEYWLEGKLSSPKPSFLVAEPVDEPGGESGKGLIIRIDNYCQGILQTDAEFLAERWQVQENGEWVKDPKSSSGAERLPCEWLMAATTKAGDSLVFGGRQWRVVESDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVE4</accession>
    <name>A0A0D2BVE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_05289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235460.1">
        <property type="nucleotide sequence ID" value="XM_016379633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVE4"/>
    <dbReference type="STRING" id="91928.A0A0D2BVE4"/>
    <dbReference type="GeneID" id="27332372"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05289"/>
    <dbReference type="HOGENOM" id="CLU_005843_0_0_1"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="484"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="948"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="948"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="965"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="978"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1001"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1082" mass="119433" checksum="68919282C6DEB335" modified="2015-04-29" version="1">METAIRFSRNSHRGTPQRFLYVDVTGKSFKLCNITKKTKLSVEYESVHTSTKVPAFRAFDWHPVNEGLVVVGQAGGEATLINIAEGYHDSLSFQVRSQRLCNAVALNSHTLLAAGLDKVRTDFCLNVWDYNQRLPAPGAKGFSKSYLEPLHKLASGEPITSLKFFHDDPQLLVAGVKGQFVRLYDLREPSVGNGLQFATRCVHNLAVDWLDENYFASGYPTSDPSICVWDRRMISRLNTPHMSFGAGSNTGTGQPDASLELKNVIESPGTIWSLRFSKARRGHLGVLSSTGNLKVYDISKDSSDETHQAEQDGGHDTSWENSAPVDIFLDRAQEVAKQHSGDPSLQDEKTRIVSFDFMTTLSKLGQPEILTLTGDGRLRVSSTNPPPEPVVLGNLDFLCKGDTVIEQSLLDASTLGKTIEEIRRKAQPRNILKRTIKQSRQEGKAPDTRKMSSLENQAWYSDLGYYERDVPLQDLLALNSIQRGRCQAGYLLNPTKNKDIVSDSNWLQSFWGWIEHSSRIAQNGNMTQDNFDLAYVGVYALWMEDIHAKNRTLGPCSNKPGKIIENLVRRLNIASLKSSKSEYVTNRQLCLHSIGLAWSYEELEARTNRLVAQNQHTKAAALAMFSLERKLAYKALRGKGSNQSHKMLAMAIAGASKKMRNVDAAATSGDDSDAQDDWAETISSLAEELTDPYARAILAYVITGDWSQVVAEDSLPLKYRVCVALRHLDDSKLTEYISRATKEVLNEGDVEGIILTGIGTRDAFGLLNSYVRRFGDLQTAVLALCPAVPRYVDDDEIVRRFDGWKDVYRHMMNGWNLRFDRVRFDIACQNAAVDESGRRLIPPAKQQVRLVCGFCAQSIAHNAGANDEASPGHKMVETPQHPLTREKAAAVGTVCPKCGRHLPRCGVCDLWLGMPDESYLPWYGPLEARLNGSKGGVIDLGASLSGSVHSVHTTIGPTKSSGNLKATTSSPAPKSSPHSQVNSRKSGATDSSAETAVPAAQESTNGVSSVPTIAVEEAATPQQGVDREVQKAEQARQWDSTMAKLTVLCLKCSHGFHAAHARMWFERHRICPVPECRCLCNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXQ7</accession>
    <name>A0A0D2BXQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_06085</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236250.1">
        <property type="nucleotide sequence ID" value="XM_016380423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BXQ7"/>
    <dbReference type="STRING" id="91928.A0A0D2BXQ7"/>
    <dbReference type="GeneID" id="27333168"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06085"/>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="39"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="302"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW16034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="425" mass="44726" checksum="B37A1424DD14BE5A" modified="2015-04-29" version="1">MSAQQRLQNIAGHINSSATSTQSQSPGLKKILEKNPDDIVITCATRTPLTKARKGGLKDTPADELLIHVLKALKAKSQIDPSKVDDVCVGNVLLPAPGFGARSAVLAAGFPVSTASNVVSRFCSSGLLSIQTVAGAIATGSIEVGIAVGCESMSTNKDAPPAGMSDMITSHPVAKDNVMPMGWTSENVARDFAVPRASQDRYAEMSHARAARAQAEGWSADEISPVTTRWVDPKTKEATTVTVDRDDGVRPDTTYEALSKIRSAFPQWGPTTTGGNASQITDGAAAVLMMKRSTAEKLGQPVVAKFVRSTVVGLEPRIMGIGPSLAIPKILDLTGLTKEDVDLFEINEAFASMYVYCVEKLGLDIEKVNVRGGAIAIGHPLGCTGTRQVVTVLSELKRRKAKVAVTSMCVGTGMGMAGVFVSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXV4</accession>
    <name>A0A0D2BXV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236325.1">
        <property type="nucleotide sequence ID" value="XM_016380498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BXV4"/>
    <dbReference type="STRING" id="91928.A0A0D2BXV4"/>
    <dbReference type="GeneID" id="27333243"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06160"/>
    <dbReference type="HOGENOM" id="CLU_072876_0_0_1"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239373" description="MICOS complex subunit" evidence="3">
        <location>
            <begin position="25"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="263" mass="28495" checksum="ECA457BF72CB6230" modified="2015-04-29" version="1">MARLRVLRATTKAALLVAGGAAVAQAPLRFPTAHAEAPLKDEVVLTSSTRARPALTVSKIPDKKPIYSSYEPSPTAPTLPADTPAPKPHPTSPTPTDRLAEQVKTARLFLYRQSLSAENGVNDLLTWAFKKETSIANTIASLAPAPETGEQLLPGAIYVLVSTMAGSIVTRNRGIFLRATFPLAVGITAGWMLIPVTMRNTSDLIWEYEKKVPAISETHLQIKDAVQETWKQARTYAQGATRWADDTAAETRKKVEDLVSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZ16</accession>
    <name>A0A0D2BZ16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236745.1">
        <property type="nucleotide sequence ID" value="XM_016380918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZ16"/>
    <dbReference type="GeneID" id="27333667"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06584"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF70">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="515" mass="57392" checksum="E8ECF96C2DC45549" modified="2015-04-29" version="1">MVFCERKSQESVVVELPALARAEANQGDVGIDENADIRQGDDVALAYYRKARQTEISEAEQKRVLRKIDLHLMPLLMVSGFLQYLDKQSLNYSVIYELREDLGLVGKQFSWVSSMFYFGYLVWQFPSLLLLQKFPVGKYFSLQVFAWGCFSLLMATTSNFGGLAALRFLLGAAESVQLAAFVIITNMYYKREEHAYRLMLWYAMNGVAIIAGGLFAYGVGHIRSSVALWKFPFLVCGSLSTAWSVVLLFLLPSNPTSAWFLNETERAIAIARVYENKTGVESKTFKRDQAVEALKDPKVWLNAISTGAGNILGGVSAFAGLIIKGFGFSALQTQLLQCPTGLIELISLLVFCSAATFIPNSRLTLSLVATAVALAGSIMLYAVNLNHRWALISGFWLMTGFIPNSFILGLGTVSANIGGHTKKLTAQAVFFICYSVGNIVGPQLYTSAPYRQGLRANVVTLVVVLVTNSLNIVYMIYENRQRRKYLDANKDHLREEDYAFRDYTDKQNPFCFNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C1V6</accession>
    <name>A0A0D2C1V6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237850.1">
        <property type="nucleotide sequence ID" value="XM_016379173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C1V6"/>
    <dbReference type="STRING" id="91928.A0A0D2C1V6"/>
    <dbReference type="GeneID" id="27331912"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04829"/>
    <dbReference type="HOGENOM" id="CLU_154777_1_1_1"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="93" mass="10801" checksum="FA389581C8C2FD3C" modified="2015-04-29" version="1">MRYSGLQREVMKLYRQCLRAAGKKPEVRANSVAFSHRLIGLKSSKTHFRDAARREFRKHQKVDKKDFAAIEALLRMGSRKLELYSSPGVKDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C976</accession>
    <name>A0A0D2C976_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_00694</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240335.1">
        <property type="nucleotide sequence ID" value="XM_016375059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C976"/>
    <dbReference type="STRING" id="91928.A0A0D2C976"/>
    <dbReference type="GeneID" id="27327777"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00694"/>
    <dbReference type="HOGENOM" id="CLU_070610_0_1_1"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="76"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW20119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="190" mass="21457" checksum="BE3F1187B230BBAB" modified="2015-04-29" version="1">MDNSSSAPDADTRSDINEAARVDDSIDARPVFSPPPYWRHNRNASYSSEFSDRPPAIILEDHTLSREASRAALWAKAITIDDYVIVQGTTGIGSYVVWNCKVQTLDGGPMVIRKRYSEFDELRSRLIKAFPHSTNSSLPPLPPKSAIYKFRPKFLEKRRQGLAYFLNCVMLNPEYAGSTIVKDFIFPPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y5A7</accession>
    <name>A0A0D1Y5A7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230327.1">
        <property type="nucleotide sequence ID" value="XM_016385383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y5A7"/>
    <dbReference type="STRING" id="91928.A0A0D1Y5A7"/>
    <dbReference type="GeneID" id="27338154"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11071"/>
    <dbReference type="HOGENOM" id="CLU_106738_1_1_1"/>
    <dbReference type="OrthoDB" id="2148716at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="139" mass="15231" checksum="E0315AB4FF8565E2" modified="2015-04-29" version="1">MPNAGGLTDREAAIDAIIRFVCSLDNGESELCVSAFTEDVVVTLNFCKTDMHYDPSIRRDDVVDVMMKKVGKPLDTNHSTADICCTVTGNSAELTTCVLAQPFQGGEGPSPEFQRSYFFGSHYKTTLVRAGELWRVSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y5G2</accession>
    <name>A0A0D1Y5G2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_11132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230387.1">
        <property type="nucleotide sequence ID" value="XM_016385443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y5G2"/>
    <dbReference type="STRING" id="91928.A0A0D1Y5G2"/>
    <dbReference type="GeneID" id="27338215"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11132"/>
    <dbReference type="HOGENOM" id="CLU_015385_1_1_1"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000281">
        <property type="entry name" value="Actin associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF36">
        <property type="entry name" value="ACTIN NUCLEATION-PROMOTING FACTOR WASL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="4">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW10171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="66419" checksum="F22D877677271E02" modified="2015-04-29" version="1">MPSILSEADKETVKRTVPKAANKIQAVAVARLYVAYPNQKRWTYTGLQGAAVLSNDLVGNTFWIKLVDISPANRGVIWDQEIYDTFQYNQDRTFFHSFELEQCMAGLSFVDEKEARTFKKKMDEREKNASKQTKAQPFASSAGGGQVHVAGSSHKHHSRVGNFLRGHRHSSNPIPQSQPQSIIPQPMYSPASTSRPQSSAGGIDLADPSWRPILDELLQMGITEDQIAANADFIKKYVQQKQAEEMANGIVQALPSVSETRSRAPPPPPPPSAPPARLSPDDTGASSSSRRGPPPAPPPSRRPVGGRAPSPPRSPSPPPRTPSPVASPQPRFRAPPPIEDAGKYAVKEGPAAYAPRRARASSGSLANPGPPPPPRPPKTPIDEEPQGMFRVPPPFMGDRKSSAPPPPPSRGPVPPPPPSRDTSTPQSMPPPLPPKAPGPAPSQAYIPPPPPPPPPARGGPPPLPPPNTRAVPPPPSSAGPPPPPPPPPPMPSSSGPPPPPPPPPPMPSSSGPPPPPPMPSSGGPPPPPPMPGASSGPPPPPLPPVGGGGDGRDSLLAAIRGSGGGGGLRKVKDSEKRDRSAAMVPGTESAAPPPPGGAPGSPAGAGDAQGGLAGALAAALSQRKKKVSGSDDEKDDDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8Z1</accession>
    <name>A0A0D1Y8Z1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_10741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231657.1">
        <property type="nucleotide sequence ID" value="XM_016385055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y8Z1"/>
    <dbReference type="GeneID" id="27337824"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10741"/>
    <dbReference type="HOGENOM" id="CLU_011099_5_1_1"/>
    <dbReference type="OrthoDB" id="4116913at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="223"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="518" mass="57525" checksum="104694C275F48A5F" modified="2015-04-29" version="1">MAPSQPVLTSTLTPNSYSASRSSDPPGHVSLFEQNSHDHRYGHTSSLRGPRPSEDVYAQLTSEISQVFNTQASGETGRVSGSLDAIDIDLNPRSRILGVRKCSMPPAQGGLFLLQEYLVDFNTAVPLFDAATISGLFLDCYNGRADGRMVSWLVVKIVLAIAHRIRAMSPLGVPQDTENVQTYLEEVIAELPALILMEPSLLIAQLYVGIAVILSTSSRPQPTSTLVSMALRVLQNIRTNDPDGDHSAMPTDLQHRERVFWIAYGMETEISLRTKISPCLPSNLISLHLPSEDDPEGAGSLRAAEGDFTINIFRLRAELGLFQARLVECVLAPGPHERASPALQEMAASLSKWRGHFLFRLEATELRNMLHRSDLVHIIILESIYFMTAYLVQFYNFSGLGLRYNLLSANGLSAAMALRDGVLPDSDARRFVQFLKLLADDEILCHWLSVEAVASAVVVTLMHIMHNPGNTDAQADLDIIRPVLHILYRLIEFRKDEDFSQLRYICADLYLRVDSMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y9K9</accession>
    <name>A0A0D1Y9K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231887.1">
        <property type="nucleotide sequence ID" value="XM_016385285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y9K9"/>
    <dbReference type="GeneID" id="27338056"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10973"/>
    <dbReference type="HOGENOM" id="CLU_036005_0_1_1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000008">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF9">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_3G01010)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="86"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="387" mass="43474" checksum="0FA189AE5B452B6D" modified="2015-04-29" version="1">MAPALIEESIKDYVVPKKDTLGLPEPTLKRLTKAGIDLSHGYPYRPNRPLYLQDVYNIRNKERKHVDAGARADKSKHALLSAATKVTDLTTHIGTEIEGLQLKDLTDQQKDELALLIAERSVVFFRDQDLSPQQQKELGEYYGEVEIHPQVPQVPGVPGVTVIWPALQATEITASFRKPGGASRWHTDLVHERQPAGITHLHNDTVPPTGGDTLWASGYSAYEKLSPDFRKLIDGKQAVYRSAHPYLDRENPTAGPQYIERTHPLVRVHPATGWKALWVNRAMTSRIVGLDKAESDLILGYLFDVYERNVDIQVRFKWTPGTSALWDNRITIHNASWDYGGNYPRHGTRVTSLAEVPYFDPSAPTRREALGLLDPDEKKVDGVLVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YA76</accession>
    <name>A0A0D1YA76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232072.1">
        <property type="nucleotide sequence ID" value="XM_016383449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YA76"/>
    <dbReference type="STRING" id="91928.A0A0D1YA76"/>
    <dbReference type="GeneID" id="27336212"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09129"/>
    <dbReference type="HOGENOM" id="CLU_078883_0_0_1"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="205" mass="22604" checksum="CB663BB4E270E037" modified="2015-04-29" version="1">MSSQVTPEVLWAQRSSSSDPEKNYIYLTIGVPDVPPKSLKLELTPTSLTFTGTSDTKKTTYHLEMQFYSEIDVENSKTHHTPANIQMILRKKELKEEYWPRLLKDPAKVHYLRTDFDKWVDEDEQNEAPEDDYMNQFGGGLGEDGGFGGIDFSKLGGGGGDMPGMEGLGAGEEGGDDEDEDDEDMPDLEEDAEEGDAKGKGKGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YB61</accession>
    <name>A0A0D1YB61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232377.1">
        <property type="nucleotide sequence ID" value="XM_016383754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YB61"/>
    <dbReference type="STRING" id="91928.A0A0D1YB61"/>
    <dbReference type="GeneID" id="27336519"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09436"/>
    <dbReference type="HOGENOM" id="CLU_008220_0_0_1"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="722"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="756"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="798"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="853"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="886"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="84"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="527"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="915" mass="102734" checksum="98C57453AFD0702E" modified="2015-04-29" version="1">MASPPRTPRKLQKRRSTPIQPTDPPQKGRADPDSPSKALLQAGGSSSFAVVAGEDGLEPLPEDSFTSPTAHLSVQVESQTDMFKCMVRLLYLRQQQLQNRWADEDSAEGILLKTGNGNYISQPRELAEACGGFSEQMRKLNVKVAMTVKTPVIQTFLATYKPPYVPYTQDQRISILDSIEEVCQAHRHHYAVFVRSTGLLVVWDEDAVEITDRAIRIEKHLVDLVWAMSSEQERDIHTIESAEPPREDATASVVTAQPLPATPAEAETGAPEAPRQTLLWQALVVGCGGCLTVFCLSIGWRNLAVEIKIDHSWTRLLLVVASPLQLWLGWFFFMTVVTTIAQLVGPVKQVFQNSKFYSAVPTKRLRDNLPHVTIQCPVYMESLDSVISSTVASVNKAISTYELQGGSASIFINDDGMQLLPEEEARRRVQFYEDNNIGWVARPKHAPNGNADGQGVFIRAGKFKKASNMNYCLSVSNRVEDKMAEVERTPTWTQEDEDRLYTSAFEAIVKEDQGRSWGAGNIRMGDFILLIDSDTRVPEDCLLDAVSELTATPEVAIIQFSSGVLNVTTSFFERAITFFTNLVYTSIRFAVACGDVAPFVGHNAMLRWSALQDVSYIDVDGTEKYWAENTVSEDFDMSLRLQSLGYIIRYSAYYGDGFKEGVSLTVYDELIRWEKYAYGCAELLFHPFHKWPLHGPVTPLFRRFITSPISWMGKLTMMSYMGTYFAIGSAWALTLLNYFLLGWFNGYLDKDYAESFNMYFGLVIVFQGAGTVSVAVLRYRTENRSLFKCLVENMTWMLVLAVFLGGISLHVSGALLFYLFGIDKSWGATAKEANTDTSFFREIPVIIRKFKFTFIYCILSVAMMMVLAGIGPLGKLVPDFWRIKSFIAIFPQGIMIVMHFFLPLVLNPGLMLFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YC95</accession>
    <name>A0A0D1YC95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232717.1">
        <property type="nucleotide sequence ID" value="XM_016384094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YC95"/>
    <dbReference type="STRING" id="91928.A0A0D1YC95"/>
    <dbReference type="GeneID" id="27336861"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09778"/>
    <dbReference type="HOGENOM" id="CLU_006033_2_2_1"/>
    <dbReference type="OrthoDB" id="2932980at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050197">
        <property type="entry name" value="Aldolase_class_II_sugar_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789:SF0">
        <property type="entry name" value="3-OXO-TETRONATE 4-PHOSPHATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789">
        <property type="entry name" value="FUCULOSE PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="16"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="299" mass="33743" checksum="0D108716837A350D" modified="2015-04-29" version="1">MDPDIDSDNEIDQVLSHLITAFHILHQHQVLDEDGQVSVRNPQDPSTFFTSNLPAILVSSKKDLSQWNVADGSPVDDPYPELAKASEHSAVSEIFAHSSIYKAYPGVQSVLHSHCASAIAYGLCSSWNSMLQPSYLMAGFIGYSPPIFDIARYYVNLPASHPRNLLINTQYLGDELAMTLHRSQREEPRRHNTPTVLPEQKAVFIRGHGYATWAESLEDVVWRAVHIRRDADIQTTAMTQRDNSELEIVYLTEQEAVDCELTINHAEQKHWLSWVAQVDRSGMYRNELDGYGAAPRTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIM7</accession>
    <name>A0A0D1YIM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235007.1">
        <property type="nucleotide sequence ID" value="XM_016381905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIM7"/>
    <dbReference type="STRING" id="91928.A0A0D1YIM7"/>
    <dbReference type="GeneID" id="27334659"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07576"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="13"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="330" mass="36218" checksum="1043C16EC67032D8" modified="2015-04-29" version="1">MVTFTVFKGDKQGRIFEDTTTRTIGEHEVLVRITHSGLCGTDIHFKTSNIGLGHEGVGVVEEIGERVTLFKKGERAGWGYEHNSCGHCKQCLTGWETLCAERRMFGEVSLDQGSLGSHFVMDENFLFKIPESMSSAEAAPLMCGGATVFNPFKVYNIKSTDRVGVLGIGGLGHLAIQFAARWGCEVVVFSGTDSKKEEAMRLGATEFYAVKGLKELKIKAPLDHLLVTTASQPDWQMYLPLMAPSGTIFPLTVSGGDLKIPYMPFLQKALTVQGSLVAARQVHREMLDFAAHHNIRPIIQTFPMSLEGVNKAFDTLAAGDMRYRGVLVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YN31</accession>
    <name>A0A0D1YN31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236677.1">
        <property type="nucleotide sequence ID" value="XM_016380850.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1YN31"/>
    <dbReference type="GeneID" id="27333598"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06515"/>
    <dbReference type="HOGENOM" id="CLU_228178_0_0_1"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000022">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1633"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2517"/>
            <end position="2548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2522"/>
            <end position="2533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2538"/>
            <end position="2548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="2548" mass="286926" checksum="1FB477BB9613A361" modified="2015-04-29" version="1">MSSSTSDSSARNRSDSTEGSGLPQHEHKRPRLSESKPDETHVMSDLQQTEKPSLAPSVTLVDENMPALEGSPHQTPPLPPRPAVIATAMSPTSRVTIQTRPLSSQSVTEPNQSLADTAKSKTSLTPNQPTSHAHGTGMDGAEDLSHSSTAELSDVEANTHEQPDTISISSSPSKSPEIEIAEVEDFDRDPTQTRWTTRIGGSASAAIPKSMQPHYVHHTFPYAGDSPGSARRAVGEIANRFQYGGAQDGELFSKVKDWMVEFVNTCVEFPQRLFEEDRDFWQYLPGLVENLLRRTSGPPPEARVEDLIEYFVAYARVTKLIMEYDARHVQDLSPDADARDFKDFAVKSMPYYQPLIWMLQPEGIPFYDALRGTMGFEIAQLLVPVLDRICGSEVALLASVSELLSSITPFLSKKQDLVKLLINLLMATSYAMKPLTSAAAAAEPIFQPSNFTQIDCIRVAVAEIMLKADDIIQQAIVKQAPWLNLESAPKIIDQLMPIVGVIAVEVPKIGQDIVATAGVGFVDGDLTDLPSTMPQAWKFKTLRKFITHGRMELRVFGVENMSNDLVQVYKERILNRPQAPTTDPLVRFLVKFIQQNQLIDYIIGVDSHPQLIRRSHNVVGFLCVSGTYTDATTDVIWKTIAESQDPRTVHEVFNLLSNCHVYDLHALCYICKKLADYPFQRFDTHVLQFTVGLLEKIRGYSESTSQQPSDPTIRRLLVRLLREASLDENLSLEQAAVIRKEFPRHLGTSLTLGGLLDASIITVDEAELHQIIRESAESLKSHEEYSSGDVLVLTVLVPIMRQSLSEVIAEFDLIGLLVADIAHLTTEFQQMLQHNVSVTFFEVAYDVRATLLYSLMLLAPTMFSKSSIESLWSSFFTAKQLPMSVRARAWETLISVMRRRQVNDQNPVLDLIINELVQGLGPQDYDETVLEFLKISVSYTIRHSGHTTPDVKDVVVIPGIDRIWRVMLEAPSDTVETQATEFIIQQYLDHQLITRQSREAIESTHSSLVDRCVQQVMASAAKLKSYADESLSGEDEPMAIIASEQEIRAEELRFDRSLLFLRKFLEGMKSRPRYSPTPSQQPQRLPGFLLKKGDEIEVSIQVYGSRYVIPEKQKVTFGSENTGNELWKYIADASGFTDFAIYHWGQGIELAGCEKTLAELNASQALFMVHKTANASEKVPTRTTRASSPVDDKIMHHFDDLYDLLDADERLSREVYTFLSLFPAQSELVRLIRSREKSPTDLLPPKKPFKLLYCARALLACIEDESFSSDPNTLFLTYSIQTILAVLPKLELSDANNPLQMSIAHWLVQALLLALRAKVPAATSQDYIEDRQGFASEIYRLLHFTLQADNATNNEVAPASMAKMIMEAFTEACLHDDRVWEHVDANNKFEELLMLAFIADGRPEVRHSLLEVVVGLTGAVGTKIHLKINNPRAARSRFPASAVEACLSHLWTTLVKALSHICTYPERCAELSEAVLVILRRIGKSITIGSIHDHFVQWSTMLLEHDHRETVGQPTRDHVVSSLTKLLYECCKLLKSNDLLPPSHRLLEKIVDRLLLPPLSVGGVLSEASLAVPVLDSTVREGLYNLLLALSQGPQDMATILAKLQDSAILERDFFEPMYVHERQSLRTEVGYAGLRNLSNTCYLNSLFTQLFMNLQFREFFLDVENFSDSRNKLVKELSKVFAYMQNSYEKSIDPTLAVEAITTYEGDQIDVSVQMDVDEFFNLLFDRLESQIDHGARDLFKSIYGGQLVQQIKSKECEHISERLEPFSAVQVEIKGKARLEDSLRAYVEGEVLQGENKYSCTACGRHVDAVKRSCLKDVPDNLIFNLKRFDYDILTGMRTKVNDEFQFPDTLDMAPYTLARLSDDGDGEPDYFQLTGVIVHSGTADTGHYYSFIRQRPSSKPVADSWVQFNDQDVTVFDPSQMRDNCFGGNADAGFYHLPKFYSAYMLFYQRTSSIERFEAQYRQHDTINPVRLSLPYNMEHHIAQQNELFLRSYCVQDSTHAQFVLNLLERMVSGPKCSDYHAIETSTLEMALDYVYQISSRWKDHPAVEETLKLVGQYAENCPACAKVVAEWFATPRVLEDVITRSPYQLVRKAYANLFTLVFSHLHALKSSIEITEDDRTQLTANYSRWLQSAIAQLAKSWDTITRSGRCWPEYFGILLALQRLGDDVVVILLDEEFLEKCIDIISIHVTNSDFPISKRLKARYGVYLAAREKNRPFNHGLLVRFLVNLVLRVDLHNIPDGDYRLTDKKIGLTPSELEVLGVGKMPPNLEWVLRLIAGQQNPAAVNELVTCLARDPILAGALSEVLHKGLNDRLIHIALTFLDPIVTFCEQCESEPRIIDLVQSALDSISTVGVEYAREYFGFVEAVLKLENQSLDEEAGFLEEEVLKTIPHWGPTFLLCPVDGQTHIRHATTELLKKLLFNPLQESESDDPRFHRQLRGLVQELAREAQAYIHTQFLTSRSRGGSPLFPGQVHQIIDVVETCLAYFDLETAQDEDQVASIQTTMAALRAKAEAEAETLSTEWQENSSEMAELSTEDFEDLQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPH6</accession>
    <name>A0A0D1YPH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor MEX67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04272</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the export of mRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237297.1">
        <property type="nucleotide sequence ID" value="XM_016378620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPH6"/>
    <dbReference type="STRING" id="91928.A0A0D1YPH6"/>
    <dbReference type="GeneID" id="27331355"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04272"/>
    <dbReference type="HOGENOM" id="CLU_642733_0_0_1"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042272">
        <property type="term" value="C:nuclear RNA export factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000018">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TAP-C" evidence="11">
        <location>
            <begin position="374"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="430" mass="47180" checksum="0BAF30617F6BD3E4" modified="2015-04-29" version="1">MATTQLAVKGWGNSKIATSSQDQGLDALLAFLERKSSRQILSNKLVGRSVLIITINEADKSRFTHLNGFSFSGSSLIVEDARPPRNAPSQSIQSPQNTSFGSRVSQPSRPQFQNGFSQPPPGPRGHFSNQSSQPPSGPRGPGRTYQQPNTRDTRRTNGSVTSDVENIIISVIHKRYHAGDKHLILNLLGEEPDFINAGLVSEPTKLYKAIFALCESKIWETLPKRKEAVLSVSLRDNSIQTIHDTLPLANAFPHIQNLDLANNALQDLEPLKFRKNQLSSLQHIILSGNPVASKPDTLSTLLKLYPNLKFYNNEPIQNATDVDIQPQQPAFGGGAVQPIQPQPQLGPEPTLAHPEFPPGSTFGIATPDKPAEVLLKEQMGLQFSFETKLKMQWVENCLSANNWDYQTAMANFAQLKAQGQIPADAYIAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPV6</accession>
    <name>A0A0D1YPV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04452</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237477.1">
        <property type="nucleotide sequence ID" value="XM_016378800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPV6"/>
    <dbReference type="STRING" id="91928.A0A0D1YPV6"/>
    <dbReference type="GeneID" id="27331535"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04452"/>
    <dbReference type="HOGENOM" id="CLU_013253_9_3_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252082" description="Peptidase A1 domain-containing protein" evidence="10">
        <location>
            <begin position="29"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="73"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="392" mass="41662" checksum="EB991DFEC235B0C6" modified="2015-04-29" version="1">MYSFNLLVTTILVVLSLLLTFLIASVETSPIGNKAETTSSPRTLRLPIRRQASSHGKRSNVFSGTLQNVEWSYLIDVQVGTPPQSLSLVFDTGSSDTWVFSPEACSSDAQCAGSFNSSVSSTFDDTSPGSFAISYGDQSHVEGDYFIDDLRVSNATISALTMGLAKTGQFQGVATSHGIMGAGYVLNEAVTGANEYPNIVYELVSQNIIGNYSFSLWLDDLFASTGTILFGGYDSSRFHGSLTTMHTLANANGMISTFLVSMLSLGATYKNRTTTFTSPTFNGAALLDSGTATTHVPSAVYAGLANYFGADANGVVDCRLGQTEGHASFGFVGVTIRVPFSELSLLDSTTGLCTFGFFDGGESLILGDTFLRSAYVYYDLGNNEIGLAQTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQQ4</accession>
    <name>A0A0D1YQQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237747.1">
        <property type="nucleotide sequence ID" value="XM_016379070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YQQ4"/>
    <dbReference type="STRING" id="91928.A0A0D1YQQ4"/>
    <dbReference type="GeneID" id="27331808"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04725"/>
    <dbReference type="HOGENOM" id="CLU_022666_2_0_1"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="46"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="673" mass="75728" checksum="A7160C9E8A81F1F7" modified="2015-04-29" version="1">MAQANTDAPALRKEHPADKIGPKLVNETDKLQNKYHPNAGSSAPEKKKGPAGGFDDTPIPYAPPGYTLKFTFHKAENLPFADLNTLSSDPYILAVLKSDLVKRHKQDPDMCIRTPTIHRNTNPEWNTDWIVANVPSSGFHLKCRLYDEDPSDHDDRLGNAHIDVSSIDENWKGFSRRSFGLKKRMGSKRAYTFRGCAALFSRNIKMDGHLIVSVENLGRTKDETGGRMYTVGPLAWSRHYSPLIGRLAGTKDTEMGKDGKETQRYNFQAVQMQFRGPVPADLYHRYVEFKPFVAGMFTSHSLRGRLLNRALHHQHSRIYNYDRMTKYGTFPEPTVDMTKLFLDLVHYDEGGRIFTYVLTLDGNFRFTETGKEFGIDLLSKHTMHSDVSIYIACSGEFFVRKIRHPKTDSNEKDVDPLEGTHKPAPESGMAEEERQNREIDRLAINQDSDEDGVQNDEKDNADADEKENDSQDAVTPPPPSSRNGKDKEKDKDEGSEGTDVPIEKSSKDTDPSHYVLIIDNDSGTYRPNGEKLHLLRDFLKTNLPGLKVVTLDCQADAERMDKLKSEQRERKKATRKPVMFMQNSSFSSLSSSDEEDLAARAAGEDPKEHRYKKQYHAFLDGGTDDHHGRRDAAAAGGTSTDEQTEKGTPPVENGRVIDDAENPVPPDASDEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YQY3</accession>
    <name>A0A0D1YQY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237852.1">
        <property type="nucleotide sequence ID" value="XM_016379175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YQY3"/>
    <dbReference type="STRING" id="91928.A0A0D1YQY3"/>
    <dbReference type="GeneID" id="27331914"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04831"/>
    <dbReference type="HOGENOM" id="CLU_008716_0_0_1"/>
    <dbReference type="OrthoDB" id="5341904at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1020" mass="113596" checksum="9D6A7E9133576A30" modified="2015-04-29" version="1">MRFAQQRPDKAIEIVREAPEARRRNRLSKPLTKKPGTSVSTTSLPEPVPKPRNASTGDRRIGGPLSSNPSDAALRQQIRSDVFGSSSDSQSKHSKTESSWSIAYMVKEAEEASVEEPRSLQQEEQPLSPVKPRKRKSLILRRLSTHRSNSFRSSTSSGRLNSLHDEATSASTPASPLDRIVDAPSIPPTRRASFTPGTATRKASRVLREEQIDEEKTLEETEDCNVIGTDFFEWQPPEPPAMMGRAGTPADLSYSHLGGLRHGSLQVVNGRASPAFSEMSKTSRSFLLAPKANRDVSSDYGDAEDEQSKVAGPDRYLPRLNTLGKKPQRRDFSRESNKQKAQQTPLRAVRSAVHPTDSTEIADQTSLMAQEYMAELPISPFSDLKTTSSHASLRKTKSEGLLQTCSSSSTPFVSPCPDHLIPKDSEIVPPSRSPSPTGSVIYKPQRMEDGEQDHNIVGLLSNEDRQHRDTDTVWSPTRQFVDQSFQPAAELEATTPRTRLQPPPAPAKSDSGYSSSSSLNSLRKDRNSEPDTDKEALQTGPSNTANTQVERQEAIPFPRSHRPWNLKSRKTAPQLTTLSDVRPAEIASSQVSALLESDAVIAKPVKTRKKLQKKRTLSQPPPKVSIGRVHSFEGQSIPSVPHGVREALRLRSEIVPELDNTYLQETSLASIDHQETEIRFPSPAPENPVEIRRSRSRSRPRSWISRSKEAKTPSQRHSGFSHHEDNTTIIHDLGTVATSLGASPYDLAHENIVSKETLNPYSISTVALRPRYIMDDRAAAELSRSKSRTVQERLGRLGGRRSSFNDRGGIPGRNIRPASFASDAPPITPEMVLNQRLASLSSVSAAPPPPPPHVRQPSYIDYEEDYSDRAWVPPPPLHSPQPLDINPDQWPLHATTRQDKLRAIGDDLRRQSWKIHNSQDYYEDYQDLGYDETLYPVISPAENQQQGLSQYNMNAPELVFSTQDRQDHGYTPYEKATYKPSSPRYYSAYTQGVPFVQKSRHYSMIQDYSYSHGGVNDFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YR67</accession>
    <name>A0A0D1YR67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_04946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237967.1">
        <property type="nucleotide sequence ID" value="XM_016379290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YR67"/>
    <dbReference type="GeneID" id="27332029"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04946"/>
    <dbReference type="HOGENOM" id="CLU_073109_1_0_1"/>
    <dbReference type="OrthoDB" id="5398396at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW17751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="161" mass="17845" checksum="7435F558218BDAB9" modified="2015-04-29" version="1">MGFWNDGIRPKDRDRSRSPSRKVYYASRPAYSRSGSSFFSSFTGGSSRGHRARPRSGFINRIRRFLREIYSYMRRHPLKVFLLVIMPLITGGALAKLLAQVGIRLPPGLQRMMGGATRQSSERFYARGGARDFDAGTALPGMGGGMGQSISSLMGIAKMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWR5</accession>
    <name>A0A0D1YWR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAUS augmin-like complex subunit 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239967.1">
        <property type="nucleotide sequence ID" value="XM_016374691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWR5"/>
    <dbReference type="STRING" id="91928.A0A0D1YWR5"/>
    <dbReference type="GeneID" id="27327408"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00325"/>
    <dbReference type="HOGENOM" id="CLU_698298_0_0_1"/>
    <dbReference type="OrthoDB" id="5575722at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028163">
        <property type="entry name" value="HAUS_6_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14661">
        <property type="entry name" value="HAUS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAUS augmin-like complex subunit 6 N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="419" mass="47233" checksum="01F5D67CD4252C57" modified="2015-04-29" version="1">MDSSNPSRFALPYRPRDYVSIFIHTLHLLDLDLLPDFPAALTESTLRSSAKVAPSNLQQRVKCVEWALYRLFEMYDPVETREKLQPHFPPSTPKDSLNLRAALYRSLTELKKNAALSRETVLRKTMLDECKGDKFEEMLASFGMLVLRKKADAHRLHSGVGVKATHNGLQNVGTEQIVPIMLAHRVSLRNTLQRRQTLKRSAAAQMDEIRQLREAIAARTALVSQNALPDEELGEDEYDALKDRLNRAFAMDRRWVTFLLEGTTAPRLGLSSSTATAAGTESPWQQQALTLAFEMVDNTAHHDDNNDDDDDDDDDTDNGDKHKNNSASEHDAAGVANEPMTQLLRSLDDRRSHIQHLKRLRDTIQRPSAPAETETETVSLQQFQTATQAETRHDHPASTSANRKKAMRFSRHQGLNLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXC5</accession>
    <name>A0A0D1YXC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240142.1">
        <property type="nucleotide sequence ID" value="XM_016374866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXC5"/>
    <dbReference type="STRING" id="91928.A0A0D1YXC5"/>
    <dbReference type="GeneID" id="27327584"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00501"/>
    <dbReference type="HOGENOM" id="CLU_030130_6_0_1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="329" mass="36733" checksum="4D57D532FD84B818" modified="2015-04-29" version="1">MSASTTNKTVKVAVIQAEPVWNDLQGGVEKAIGLIKEAGKNGANVLGFPEVFIPGYPWAIWSQSVGDCAAFMDEYFRNSLVKESPEMDRIRDAVREAGIFIVLGYSERHNGSIYIAQSFIDPTGTIVHHRRKIKPTHVERAYYGDGQSESLTTTAETPFGRVSGLNCWEHSQLLLRYYTYWQNTDIHVASWPLIWDMPPDGSPWQWHITPDASNRFSQVMAMEGGCFVMTATQILTEKNKKKCLLDNYSYARAPGGGFSMIFGPDGKELVKPLDPGEEGILYADVDLSARALAKHNLDTVGHYSRPDLLSLRVTKHGEKHPGTQVHFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZJ7</accession>
    <name>A0A0D1YZJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DCG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240962.1">
        <property type="nucleotide sequence ID" value="XM_016375686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZJ7"/>
    <dbReference type="STRING" id="91928.A0A0D1YZJ7"/>
    <dbReference type="GeneID" id="27328407"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01324"/>
    <dbReference type="HOGENOM" id="CLU_053002_1_1_1"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30102" checksum="AEDD2CE182CC7559" modified="2015-04-29" version="1">MGTTPKVRILVINPNTSTHMTEALKPVLEDLKMPSVEYSFFTSPTPGIPSINSPEDAAESAKSCLPLLVPLLPHHDAFLVACYSQHPLVTQLKRECKRLIRAATSGSDGHGARKYVTGIFEASVLASLAVTDDAEDDGFGIVSTGKVWEKALKTAVEEFLGEAGNGNGDAKKPSRFYGCETTGLNASELHDLPAEQVRGKMMEATKRVLKRGQYQHEAGETTSSGSASRVKAICLGCAGMVGLENAVRQACIEELGPEAAKEVSIVDGVKAGVALLCSLARTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z9W0</accession>
    <name>A0A0D1Z9W0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Charged multivesicular body protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_11903</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847502">
        <property type="protein sequence ID" value="KIW09802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230018.1">
        <property type="nucleotide sequence ID" value="XM_016386210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z9W0"/>
    <dbReference type="STRING" id="91928.A0A0D1Z9W0"/>
    <dbReference type="GeneID" id="27338986"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11903"/>
    <dbReference type="HOGENOM" id="CLU_086201_0_1_1"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW09802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24085" checksum="27B6DBA35A1B0CF6" modified="2015-04-29" version="1">MGNSQSAHKISAQDRAILDMKNQRDKLRQYQKRITVITNRETEIARECLARGDKSKALLALRRKKYQESLLSKTDAQLEQLEKLTSSVEFALVQKDVLFGLQQGTQVLNMIHKEMGGLEGVEKMMADTEEARRYQEEISEALAGQMSNEDEDEVEDELEAMEREITGVSALPDAPNKTVLGEGSLPDAPQTELERLQKQKERAKQRRIALEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZA72</accession>
    <name>A0A0D1ZA72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230133.1">
        <property type="nucleotide sequence ID" value="XM_016386001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZA72"/>
    <dbReference type="GeneID" id="27338776"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11693"/>
    <dbReference type="HOGENOM" id="CLU_973296_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="286" mass="32378" checksum="219E4605157894B3" modified="2015-04-29" version="1">MGQLPSRTDQSWPEWRDQREHILMEKLLKGLLDSLRSARMGRLVTQPSNHDMTCFTFGCTAQDIDRGVLRRDTFVSNMVPQQESSVHNVQHPGNTSSVEKRTIFTIRNLENNVKGGDNSTSPSEPTMDFVLGATLQSKVDAFIGQRDMGTDSGKDALTNDIRIQASWTHENIIALQRCSQSMKLPQQDIYAYSGQSNDLQISLDLLVQERADLENQLTTALHDLEETRAVILTLQDVLDKERAEKRELQAQLDDYFLTVKSIHAEWLTMKEKIASCKSAQQQLETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAL9</accession>
    <name>A0A0D1ZAL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_11813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230253.1">
        <property type="nucleotide sequence ID" value="XM_016386121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAL9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAL9"/>
    <dbReference type="ESTHER" id="9euro-a0a0d1zal9">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="27338896"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11813"/>
    <dbReference type="HOGENOM" id="CLU_006586_14_4_1"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="10"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW10037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="539" mass="58682" checksum="C2C911BC1AEEA714" modified="2015-04-29" version="1">MTSTLNHPTLGEITGRDGDGVTQFLGVQYATLENRFAEAQVKSSYSTPLNATAHGPSSFGPVDAFDNEMLFIQQTVPKPPTNHSDLECLNLNITVPKTTQKKIPVFVWMHGGGFLLGGNSWPHYDHAKIVKLANENGVPVIGIGINFRLGFAGFMTSEELRSKGFKTNNQLRDQRAAYIWVKQYIEGFGGDPDNITVIGESAGAAATTLQLYSKEKIFNRVIATGGSCLLTPTFPKEACEGMYTQALSFLGLESLGVDERINKLLTLPADEIIAKLPPFVQFVPVIDDEIVPVRPTYASIGDPSDKSMSGKEWADGVMIGDSQFDASVFGFLMAHLKPNCRENFSRSLRKTFASTPKVGETLIEAYSLGAPASPNQAEDDEISFKNFLKFATDIGFYSSTLTFARGWSEGAGKVYTYFLNEPNPWPGAYQGETTHVFDVALLFQNYNDKLPPEQKAAAEGFGLDLMKFVAGQAPWQSYTPAHRAAKVFGPSLGKGQAAAKVIDDAESPETGRRMTVLELSKEVGFDAISRGLGNFIMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIA6</accession>
    <name>A0A0D1ZIA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232818.1">
        <property type="nucleotide sequence ID" value="XM_016384195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIA6"/>
    <dbReference type="GeneID" id="27336963"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09880"/>
    <dbReference type="HOGENOM" id="CLU_020884_2_0_1"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000048">
        <property type="entry name" value="Zn-dependent hydrolase/oxidoreductase family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="117"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038896-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="412" mass="45812" checksum="69D2754668606CE7" modified="2015-04-29" version="1">MAYSSSTSALVYAATVAVPSIASARPDDDITKAKAWHVKSGGFNNPWPSWDMHSAPTIIRGMLMRRFSGRANIPNTTPPTVPVHAPTFLPSRTSSTSLRATWLGHACYYVEFPSGLRVLFDPVFTDRCSPFSWLGPKRYTEMPCQIRDIPTIDAVVISHNHYDHLSHPTIMEIHKLHPKCHFFVPLGNKKWFEACGITKECTELDWWDDVDFTLTPSSSPAKSDKVSISSADTPSAKPTTDADAITSRISCLPCQHISARSVHDRAATLWSSWSVTSGGKSVYFGGDTGYRSVPKESDGKDDWGEEYAHLPHCPVFKDIGDLKGPFDLGLIPIGAYMPRWIMSPMHADPRDAVEIFRDTKCKRAMGIHWGTWVLTEEDVLEPPKLLKKALAHHSIPETGVFDVCDIGESREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJT0</accession>
    <name>A0A0D1ZJT0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233278.1">
        <property type="nucleotide sequence ID" value="XM_016382575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZJT0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZJT0"/>
    <dbReference type="GeneID" id="27335332"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08249"/>
    <dbReference type="HOGENOM" id="CLU_015101_1_0_1"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="336" mass="37343" checksum="0BC57635EC45A2E1" modified="2015-04-29" version="1">MLPRQAKNKPWSVSKFHSLLTFGDSYTDESRLGYFIQNNGSAPPAGVLLPESNSTAGGGRTWPRYVVQYTGSTKNGEWNPSMTLYNYAVSGAVCSNKITPRWFSAIDAPFPSVLEYEVPAFQADMKAQRVNATPAEAFFTPSLSAQSAVYALWIGTNDLGIWAFLTDSQVRGKVLTDYTSCVYEVFDKLYAAGGRMFVLMNTAPLHLAPLYANSTLHGVGPNQYWPNKTSNHTQIAETMHEYTSTVNGVFKHQTPFEVLVAHRYPDAHFAVFDTYSLISDVYDNPTKYLNGTGVEAGTESVWGYINHCNVNQTVCEKVDNGTNSDGFLWYDELHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZKU8</accession>
    <name>A0A0D1ZKU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoporin POM34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233663.1">
        <property type="nucleotide sequence ID" value="XM_016382960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZKU8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZKU8"/>
    <dbReference type="GeneID" id="27335718"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08635"/>
    <dbReference type="HOGENOM" id="CLU_044363_0_0_1"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="38836" checksum="D494E701075E3F01" modified="2015-04-29" version="1">MSTTATSLVPLSVKSTAETALQGSQSVASALRTTQNIVSSEVASGTNYLKRRVQEAGKTPAKSPLNSTNFSTPPPSPGNFRHPRITEILARESATSISERRVKGAAVNAAVLLFTFIFHDAFCSVVTWLLSWSGFDASQALSTTIVIARLVSCANIVLCLQPVIPYISKKDQITDIPLTPSQRSLLGLDPSVQPTPSPAGSSLSYITPPRYRRSSGSFSGSSQSANGGGLSSTGRRSISANYASSPLSTSRNAIGFSSGTPIRRTAETGSGFSPSPAASPLFHKSLNNQSSQIPDIDFGGITGRSSFGASTGSGLARSQSLRERPRRESLEPASPASRTKSPQIVPGVNYKWLYDKGRALPKSESYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZMG8</accession>
    <name>A0A0D1ZMG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_06768</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234203.1">
        <property type="nucleotide sequence ID" value="XM_016381101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZMG8"/>
    <dbReference type="GeneID" id="27333851"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06768"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF51">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="528" mass="57767" checksum="D1787481DA42F375" modified="2015-04-29" version="1">MSFPVGLAEEKPSVFTTETLANDLEKSGATQDDKPINHVKVDEKISWWTSLRQNPKAFGWCCYMLFTCIMWGYDGLASAIVLSIPKFREDYGRLWHGQYVVSANWQLAFTAASMIGLMLGGICSGLSMKHVGQRWAMAVGYVFTTAGVFLQWYSPGHLAMLFGGKLLTGIPLGVFLTTAPVYCSEVAPPSLRGAMIAAVNWSIVIGQLLSYGVMRQTQSRDDSMSYRIMFAVQWGFAGVGAALLPFCPESPMRLLARHKLEDAKTSIARLYNSDVVDSKVAEIQALLAHEAGLAANAGTWLDCFKGTNRLRTLIACSVFFLQANSGVSWVVGYMGYFMQLGGMKPKTSFDLNVGVTGLMAVGCMCGWVFVEKIGRRLTILIGLIACTVCLLVIGILTQFIDHGSTIVYTQVGFMAVWGFMYQASIGGVGYTLISEVPASSVRSQTQGLATATNGLFSSVWSFALPYMINPDEANMGGNVAFLFFGCLVVGDIFVYFAYPETKGRSFEEIDELFNRGVRPRDFAKTKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZP36</accession>
    <name>A0A0D1ZP36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234763.1">
        <property type="nucleotide sequence ID" value="XM_016381661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZP36"/>
    <dbReference type="STRING" id="91928.A0A0D1ZP36"/>
    <dbReference type="GeneID" id="27334414"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07331"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="80"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW14547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="545" mass="60808" checksum="F7D957706A242FC8" modified="2015-04-29" version="1">MTTKTVAKQPWEERVKIPRKVRDDSVARVDPPLQGLPDKLPQNSQGLAQAVLTPRELEITGKSAIELLEKLQSRELSSEEVTRAFLRRAALAQHATNCLTELLWDEAIERARYLDSLPEPVGPLHGLPISTKEHHGSKSKNGVANASYVYWIGKPQGSILLYDILYDAGCVYFARTTQPQTIMHLETESNIYGRTVNPYNRNLTPGGSSGGESALIGFRGSVLGVGGDIGGSIRCPAAHTGIYGFKPTTKRLPSSGQRTHMIGKETIGSTLGPMATDRDSLELFMKVALAAKPWRLDPGLTAKVWTPYHFTKPLKIAVQWWDGVVKPHPPMLRALKEVSEACKAAGMEVVEWDCTKLDHKKGWDITAGLYWPDGGAEVLGMIEEAGEPILPLTKFIIHEQPTAKNYNMHELWQLVAERDAYRERYARAWTDTGKDDGREVDVILCPPSFGAATPHEQSRYWGYTSNWNLLDYPGVVFPVTTVDQEKDKKDVDYVPKNAEDKFVYEMYSPEKYLDAPVNLQIIGRRSYDEKVLAALVEIEKALGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZP77</accession>
    <name>A0A0D1ZP77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234818.1">
        <property type="nucleotide sequence ID" value="XM_016381716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZP77"/>
    <dbReference type="GeneID" id="27334469"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07386"/>
    <dbReference type="HOGENOM" id="CLU_2084869_0_0_1"/>
    <dbReference type="OrthoDB" id="10416128at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="122" mass="12360" checksum="2B449BC451DEACE0" modified="2015-04-29" version="1">MSPTSAVKQTQEIPAAAAAAVVDDVTDGFTANESVPETDTGTATRGSAADAVVGGEPVGDLAAKSNAAVANRHRDPDVEPPRVSKDQKPDITAESAPADTSARKTAPTLDTDQVPPNDEKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPD4</accession>
    <name>A0A0D1ZPD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_07456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234888.1">
        <property type="nucleotide sequence ID" value="XM_016381786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPD4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZPD4"/>
    <dbReference type="GeneID" id="27334539"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07456"/>
    <dbReference type="HOGENOM" id="CLU_029393_1_2_1"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="103"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW14672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="456" mass="51294" checksum="D7057CC70BEABC41" modified="2015-04-29" version="1">MKTRAAFRPLLGWCRYRDGVLLRRQGLRWASDTWAPGPAQKAGAESVNFPGALNSSFTSMMKFHNPAEVTAMPTYRIMDADGNIVDNTRDPQSASDEDVIQWYKTMLTVSIVDLIMFDAQRQGRTSFYMVSAGEEGIAVGSASALTPEDVCFLQYREQGVLLHRGFTLKELMSQLFSNKDDNGKGRNMPVHYGCSRINVHTISSPLGTQIPQAAGAAYALKMQRLINPNVPPRVVACYFGEGAASEGDFHAALNIAATKSCPIVFVCRNNGFAISTASIEQYKGDGIASRGMGYGIDTIRVDGNDIFAVREVMREARKRALEGNCKPILVEAMSYRVSHHSTSDDSFAYRAKREVEEWKRRDNPITRLRKWMEKKGIWDEDKEKEARASIRKEVLREFSAAEKVKKPAIREMFTDVYEEITPEAREQMKQLKEIVEKYPKEYDLSVHEGGVKTLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZVN7</accession>
    <name>A0A0D1ZVN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236998.1">
        <property type="nucleotide sequence ID" value="XM_016378321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZVN7"/>
    <dbReference type="GeneID" id="27331055"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03972"/>
    <dbReference type="HOGENOM" id="CLU_078149_0_0_1"/>
    <dbReference type="OrthoDB" id="5377026at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="1">
        <location>
            <begin position="7"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="342" mass="38381" checksum="08953CF9E53F76BF" modified="2015-04-29" version="1">MGKVVAAVGLSHAPGALAFPETAQPEVRKRTEDATRSLGISLESSQPDVIVAFLDDHFENFFRDLCPSVVMGIADQHVGPADQWMETLRIDKKTIFPGAPALAEKLLGSLVSQGYDVARAGPCEYGNNLLMPWKLMGVEQSLAGVPVIPIFINVFTPPLIPYRRAYTLGEAVRHGIETAWPADTKVAFIATGGLSHWPPYWNPIQGGDPPSDPFLQRIKRYQTEGKAYLKQDPRLFVDFDDYEVEMAKKNEYPLNSKHPLVNWDWDRMFMQKYSAGDIEWMKNLTYEEVEEEAGHGGHEVLNWVAMLGAMKGAQSKMLLYEPVVEWICGMVYQDFCVTEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZW08</accession>
    <name>A0A0D1ZW08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_04067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237093.1">
        <property type="nucleotide sequence ID" value="XM_016378416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZW08"/>
    <dbReference type="STRING" id="91928.A0A0D1ZW08"/>
    <dbReference type="GeneID" id="27331150"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04067"/>
    <dbReference type="HOGENOM" id="CLU_508081_0_0_1"/>
    <dbReference type="OrthoDB" id="3695171at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="59882" checksum="3D4F006EB11E8EAF" modified="2015-04-29" version="1">MDPISAFGVAAGTLQVVDFAAKALLGTIGILKEASNTPKRMTLLLQDVEKSVEHIRLLRELFGGLESLSGKLNGSHLDHVNDNITDICEAIGDLKNTLEPVVRNCNASSPHKHQQILAAMKSVTARSQVEQKASRLILLGQILSASLQGVILESQEILTKQIGQTSLMSQFQHDELTAQINSLKLMSQSIQGNIQDHQLVVDRLQQKVASSETQIDRIHDHVAGLSQSLDSIDSRSQRIEANLEVSQADLRLNQMRFQHTLQSAIKEYDATRKEIFQLRDDFMQWIAGNHGSLSSPPESFNRLDDTMKSNVRLSLISKLAEAPSALKSACEHVSYGIRTVRKSTRADSQSTQGCVCVPTPDRRITRKGCVSFEYESISEHLPKCRIYQNRKRFRNYTVAVQPLPLIRSTLALIIKNKSGAGGCSMGISLSYHRTVKRSESELFKLFDSFPRKLSKKAYSHSSLSEEMSFLQDYEGGEPPSTITFSCMPMEIEKETSEWVQSFNKLLERGCVWDKDEHGNTCLHVSRPEEFLAAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0P2</accession>
    <name>A0A0D2A0P2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_02800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238728.1">
        <property type="nucleotide sequence ID" value="XM_016377158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0P2"/>
    <dbReference type="STRING" id="91928.A0A0D2A0P2"/>
    <dbReference type="GeneID" id="27329883"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02800"/>
    <dbReference type="HOGENOM" id="CLU_037227_1_0_1"/>
    <dbReference type="OrthoDB" id="4149656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="43016" checksum="03571ABCF7096299" modified="2015-04-29" version="1">MESWGSSTRDTENNNQSADEAKKALEPVFSVGDNVALQNFQSVFRTGVDDPALLNAVLLTATYAATKDVLDHEYLKYQTETMRIVRERISFFDPSTTVSTMGAILLLAGIETRLGMRSQVEIHLKAIYQLLQSSRVGQVYLTDGIKRAIFWQDLYAHILTASERIVTHELRWERDIFPSDIFVLSPGFQRKAHLFPEEFLEVLVDIHAMQSCRDSSFFAYEDTVSMMRVDNQQASVQSKLANLPNMPYVVECSRWAAYLAASMLCCKVWRLSVMPPLISSQLLQKLQQEHDESDWYGHSDLLSWMLYIGGAFAPRGPTRTGYIKLLQKQAEFSSEFMHLSLSWSDLVQDLRQFVWSEKAFSTQVRSFWDEVQSAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A1E1</accession>
    <name>A0A0D2A1E1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial ATPase complex subunit ATP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239003.1">
        <property type="nucleotide sequence ID" value="XM_016377433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A1E1"/>
    <dbReference type="STRING" id="91928.A0A0D2A1E1"/>
    <dbReference type="GeneID" id="27330159"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03076"/>
    <dbReference type="HOGENOM" id="CLU_047290_1_0_1"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="40101" checksum="2F0EF75E9B48692F" modified="2015-04-29" version="1">MGREEICSLFVALALRPHSRCIYRTHRTWRPHIRHASSSNAPPAAPKQQELPKQPTIPLHVGLDRNPDAVSAISRIPIPRGERGEKFTPSVLSRPLGLEHPPLPGQNSPIDTRSLRERKEDFANYQKALERRRIYLRSYFRPYFQEWNRTEHYKGKSFVSNERLFRRDKALYFPNIWGQTLATEGDGPNGGRDLTPTITGKISLIGMQSGQWAEEQVDTFFGPKDNPDLSGIIATSNGLVQRVDVNIQGDWVRAWLVKMFRGRLRRMIPEDRWDKYFMIKLPRDIRRGLTDDVRDAMGLLNSQVGYVYLVDSSCKIRWAGSGHAWEGEVAGLNAALQRLIQEERKFRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A1V7</accession>
    <name>A0A0D2A1V7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_03211</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239138.1">
        <property type="nucleotide sequence ID" value="XM_016377568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A1V7"/>
    <dbReference type="GeneID" id="27330294"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03211"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF72">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="17"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW18922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="504" mass="55586" checksum="BA0210BE27273AD3" modified="2015-04-29" version="1">MRYLEWFSPGRATRTAVAVTCGQAFFLFGYDQGVFGGLITNPDFLNIFGHPAPGLMGIIVSIYNLGCLFGCILNFFVADPIGRRKAILVAMFFISVGAVIQCSSYSRAQLMVGRFITGLGVGIDSSTVPMYQVELCKGDNRGRLVSTEVIFIALGISFAYFFDFGLSYGSGPFVWRFPIAFQIVLALPIAAIILALPETPRWLVQQGNLDEARSVIQRVYGLSETAAQVDGQLKEIVDAVELERSTEFKWSAIFRRGDPLQTGYRVFLACLILLMNQWSGINVVVFYAAVILEDSVGLEHKTAIVTAGCVNLAFAAGCIGPILGLDKIGRRPLLMIGTAGQAVSMALIAALLSFKGTNKEHATATASVAFFITYMLSFGSSLFPIPWLYAAEILPLQVRAKGTALAVMNNWVWVFTIVMITPTLVHNIQWKTYLVFMSTNFAFLPLIYFLFPETKGLTLEEIDYIFLKRDRLQDDHSDNQSPGDLTQQEEKKAEYVENVVASET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A301</accession>
    <name>A0A0D2A301_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gluconate 5-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239513.1">
        <property type="nucleotide sequence ID" value="XM_016377943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A301"/>
    <dbReference type="STRING" id="91928.A0A0D2A301"/>
    <dbReference type="GeneID" id="27330674"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03591"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="29293" checksum="BB242C7582620C73" modified="2015-04-29" version="1">MGSAQTDVELQDFGSIFSLEGKVAVVTGGSRGLGLHVASGFMQAGCSKVYITSRKAKACEEAVAALNALPNKRPGAVAISIPADSAKISEIERLAAEVAKTTDHVDILFANAGATWGAPFETHPESAFSKVMDLNVKSVFYTAQKFEPLLKKQANTENPSRIIITASVAGLGVGTLGENATYAYSASKAAAIHLAKNLAVELGPRGIITNAVCPGFYPTKMASGLMELQGGQAALAAEVPNKRLGHPEDIAGLVVFLSSRASKHINGAVITTDGGSLLSRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A3W6</accession>
    <name>A0A0D2A3W6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_00104</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239748.1">
        <property type="nucleotide sequence ID" value="XM_016374472.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2A3W6"/>
    <dbReference type="GeneID" id="27327187"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00104"/>
    <dbReference type="HOGENOM" id="CLU_002034_1_0_1"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057344">
        <property type="entry name" value="ARM_SRB8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25326">
        <property type="entry name" value="ARM_SRB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="13">
        <location>
            <begin position="251"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW19532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1494" mass="166251" checksum="50B5C6429FDFC89B" modified="2015-04-29" version="1">MTSNPPAEPRPPPLRRPPDVPRPSLDRAASDALSSSGRRPAGPQRQYPEPTQDRPTKRRKVEGDGFLNQASSNGNASTATTTQHGASQLRLVPPSASALLFGAHPSQYGKWLEGGADNGVPDLPHRPWDLGRQSKTTEDPLPTHRSRIYVPVPTTPDSLASPERVPHFVPKKAAGFFPWTGKHPEDVLNDVNVKQGYFDKPPNPTEKELNTARVPLYNALKHKSGVDSLSVLFSLILDKKSQQSIINVPTTFKPPPRVTLTEAKRKSWIADLANADVPLRRLSRTIPQGIRGQLLLDQCLQNHVPLSRAIWFAKCVCANEIRTLKRKGTTPAVAMGSEGKWLREWTTSVEQFLESYLGQAGNSDWRSNIQYAIRISTRLYMENLLDRDHYIDWILRSFAAASLQQLPFWLMVSHIYKQDMSYYRRRGRRLAETLIEKYELVRKTAGPGAAPLLQRLHHAIRDLLLSRPRNFLMPDRWPEVYSVVQTCLDGKIQQEKQILEELNRINERTMGFNKGDFCNKRSAVQEIVEVLDTLKPPFDVAKLAANLTTICSDTGVLISTCFEWACTRFRSSDARIHLFARLLRRWQRAGLDVDTIILNYLSSCREGKTTADTQCLRRLVAQLSRSNSFPTAKYLQWLMVRGLPKAGTVTLGQDTGAGTNSISDFSKVNFFLLDLCLQNTGAHVINLRSSILARCGFDLNSEEELYQHHIRYIEQQLSRSFAGASSSTPNISEPSFASLPWSVKSKISVWLRARAVQIAMRDMPGPLTSTRSDCAQFAFIRYILECMGDEPVLADVIGILCNTQDDALMASLTATVQAHSEVLQSIGAFDVLQRRLCQIYMSWRSTKPAMPLFTNFLLDLCSTYPVATPSVKSLQQDFVRGDRGRAVAACSPYSDGIAESLQQAGATFVEDFEAILQSEPNMSEQTMNGLFSVLVDRIEKQQKFGDDSLTLFSFCQLLSRLRLCRKGQADKLIQKWLTRLAPFLDATFGPCLFQNLIGAGCVTFAGFLEAMDLTKLQLRKLPSAATLLRWLHAPDRESLSNLAFYQTRIRWTEYCRGEPQHVLEVLTQLGRPDSQAPLPISLVHSLANDLPLTSTRPSESVTALLLQTLDGFLNLGNATPDAVDLRGLLSGINIFSCRHIQLRLWLTSARTTSEGQGQLVDILTDVLERTLQERDVQQCNVAQLLHTAGSEVANRLRHKVESEFLEALPKFPMGRTSSPLSAVFPSDIQHLSEIVDRAFRVCVKDTSPMTGFMTQLLEKLTQIFKSQNSHVATSNPSSMTGLSGNSVTANHAQMVTSSPNAIANTSEGGAGGSNGWATVNYLDAILYMVCLQRLSLISAGRTGPNTKQGQSEQVQLLVRLALIFTHPAIAALTALSSNKQEQEKVKNVHDFILDVIATIVDQVGDEVKMMCAKLLKDKMHDVRLRYLFGSVNITGSVQVQDMGQGLQMVKEGKGIIGEWRPRVWEVLDNGSGKENETPLGLGLFGARRGRLTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4Q9</accession>
    <name>A0A0D2A4Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_00387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240028.1">
        <property type="nucleotide sequence ID" value="XM_016374752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4Q9"/>
    <dbReference type="STRING" id="91928.A0A0D2A4Q9"/>
    <dbReference type="GeneID" id="27327470"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00387"/>
    <dbReference type="HOGENOM" id="CLU_036208_0_0_1"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW19812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="62884" checksum="1DA255AB100C92B8" modified="2015-04-29" version="1">MSSATGRGTTLPDEILAMICAELGNDNDFGSLFSCALSSKSFADPALRTMYQRHQFSPVFEQRDDLVMQKEVDFSTKAAEEKRLYQKWNLLWRSIISSSLDDTRWPTYKPYCRYITTLDFRNLLAMVDDFKFTPQVQSQFFKKGLQKFWFPKKEFARQTVDGVATVNAVGDALTAKTHLLEEINGHVSQGHLSDWIALSPKLVSMVLWKGDALSNGAGKAIAQHCESFKSLTIHEWSSPDADIACSTFLNDLKPDTLEYFEMISFNTLGKLSFAALGRHKSLRELSLSNLDKEAMLNLNALKECTELHTLKLDDNLGNVQLQRLYNDVFLEVVNWLSSCRKLRDLSLKKFLDGPGILSRVLCSPNVHLTRLSLEGYNVRTTDSQLFHSALPEQQSLESIWLKGQGEYTTSDDLAIMVQGLCGLKNLKELVLKDVSDEFTETHIATLALSLPHLEDLWTSGGEISEDILGILAGLDKLKNLTLYALTQFSSEAILDFLERLNPVTQKGFNLSLMAAHPDYDLTEAEQDLIREYIRANLDGRFDLVVWRELETSDSEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A5K3</accession>
    <name>A0A0D2A5K3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240233.1">
        <property type="nucleotide sequence ID" value="XM_016374957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A5K3"/>
    <dbReference type="STRING" id="91928.A0A0D2A5K3"/>
    <dbReference type="GeneID" id="27327675"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00592"/>
    <dbReference type="HOGENOM" id="CLU_648957_0_0_1"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="46"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="383" mass="42224" checksum="F420306FAE911837" modified="2015-04-29" version="1">MPTLSASPPYRRGVSFDTFDTEDAPFKHFTLSFAHSDYAAASDRRVFLCGIDGTESSDLVLDWALSELVDDGDEVVCVYRVEKESMFTSWSRSKGGRHRIEAEKLLDSVVSKNTRDKVIKVVVEIVGGKTSTVIQSTINLYEPSALVVAAGDGTSSDVQKMLSGSVSNGCWQQPMVPVIVVRAGMARPRRNQQQQQHQHQQQDQGRRWSDQRSLSISHSLSSQDSAVSTQEMAKGTAKVGGQSHRGILKNKHERLFIKNDSGSSDGEADETLGEKGFILPIGFLSTESVPKADLALKSPTIAALEEDWDDDELGISSRKVQQQTVKDRGDDPVVSDDEDGLKPMRIVEERRPSVRETTPWLASILNATEKNPRGHNRKSRANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AV12</accession>
    <name>A0A0D2AV12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230749.1">
        <property type="nucleotide sequence ID" value="XM_016385805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AV12"/>
    <dbReference type="STRING" id="91928.A0A0D2AV12"/>
    <dbReference type="GeneID" id="27338580"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11497"/>
    <dbReference type="HOGENOM" id="CLU_023529_2_0_1"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="274"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="498" mass="57851" checksum="68E0F8379F1EC70D" modified="2015-04-29" version="1">MNPQMNYRQYAQPQGRTPQARRPVAYPGGAPNPMVAAQQAAQREQAAIMEAQAKQRIAAADHQRAQRIARKPTDLDLPDSLEEIVIGDGVQQYNALREAEKRLDAIMMRKRLEYMDSASRNTKHFKTMRIWVSNTVEDQFWQTEWPEGDTFRLEDIKTPTYRVRIHGMLLEYKEDDISYRSDDEDEDEVEGESSSPKKKKPKTKTLIDPPSRPFGWFWKDMHVEFEGQNPDYTLDENVTVNWKKTPESADVDTIYFKRRGDHNQNITICLTRDEQPERFRLSKALADALDMEEADRAEVVMGLWEYVKFFNLQEDDERRTIRCDNNLRQIFGTDTIFFPQVPERILAHLHPLPPVKLHFTIRVDEEFHKNPEPTVYDVQVMVEDPLRALVIKNTNSPENIARNREISRINDEIAVLMQAIRHSKARWKFFTAMAKDPIGTTQKWLASQKRDLSVILGEPEKGDVAGLEFMTEVWDSDIVREAVRYRLAKMDVGGGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWK5</accession>
    <name>A0A0D2AWK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231081.1">
        <property type="nucleotide sequence ID" value="XM_016384479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AWK5"/>
    <dbReference type="STRING" id="91928.A0A0D2AWK5"/>
    <dbReference type="GeneID" id="27337247"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10164"/>
    <dbReference type="HOGENOM" id="CLU_017936_0_0_1"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW10865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="504" mass="56121" checksum="194B3C06A455A4DA" modified="2015-04-29" version="1">MSSRSRNGCIDCKKAKVKCDEVHPFCGTCRRRRRQCSGYIQPIKPSRPVSGPSSPRTPTTSVRQLTDHATSPDRRLSEPQPFVPPALYAGAFSPGPGSLGSPLSPVAFNSTPSIDLPLLKSIPTIPAGTINPADETFIEMYFLRHPKELVFGPEFVEEMNSSVIKVLQDSPLAVGDILSAIGEAYCKDSALPLVLPVASRRARILARLRGMDKHGVSMELLLSIMLGLCAVELVDSSAQRQTSSLPVLLDNLSMMLHRHLGKGDDLNQLAKYFLRAMARQDMLISLTRMHRSKIPTTWWLDDGAKARADRFMGYTGTLMPILSRLSDLAADIRVSWLETPRHSVEGNLHARASNLQYELSMWHPIVDPKLPFQSSRKFLMHANSYRQASLLYLFRLFSPPGSSAEADRAALTMAYEVMSHIADHEEDLKMSLWPVFLAACEMCSESDRLSVTNVLDSICRSRKTVTALGTRSFVLNRVWVARDAGIDWSWMTLNVKYPNELLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYI5</accession>
    <name>A0A0D2AYI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231994.1">
        <property type="nucleotide sequence ID" value="XM_016383371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYI5"/>
    <dbReference type="STRING" id="91928.A0A0D2AYI5"/>
    <dbReference type="GeneID" id="27336133"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09050"/>
    <dbReference type="HOGENOM" id="CLU_023867_0_1_1"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000457">
        <property type="entry name" value="rRNA processing protein Pwp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="274"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="411"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW11778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="549" mass="61141" checksum="CA2098B3260C62E5" modified="2015-04-29" version="1">MSMTLATTWVRRGVAAQFPTKYQVDEAELDRISRLARLQLEDAQEDLERAQNPKEDADESQDTDSDNGVSTMEASKASETKADEDDDLKEYNLDDYDDDEPDEQTQKFAMFGNVGSLAYHAPEEEDPYLVLPEGEQESEDEREELQILPTDNLILAAKVEDEVAHLEVSVYEDDADNLYVHHDIMLPAIPLCVEWINVPVGKDAEKRKDGNFVAVGTMSPEIEVWDLDVVDSMYPNAILGQEPETAAEGEQEMDSKQQKKKKSTKKKKKPKANDEYHVDAVLALAANRQHRNLLASASADKTVKLWDLNTGKCAKSYTMHNDKVCALDWHPTESTVLLSGSYDRTVVATDMRAPDAVAPRWVVEADVEKVRWDVHDPNFFFVTTEAGTVHYFDAREAPTAHDKPSKAKWTLQAHDGAVSAFDLNPAVPGLIATGSEDKRVKLWNIENNIPSMIVARNLDVGRIFSVQFAPDPEVAFRLSVAGSRGQLQVWDVSTNPGVRKALSGKVKLPETEGKERVVAINDSSDESDDDDGGEMDAEGRDGWESMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYJ4</accession>
    <name>A0A0D2AYJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kanamycin B dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_10760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231676.1">
        <property type="nucleotide sequence ID" value="XM_016385074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYJ4"/>
    <dbReference type="GeneID" id="27337843"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10760"/>
    <dbReference type="HOGENOM" id="CLU_043410_0_0_1"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW11460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36281" checksum="06ABD26AD023FBFA" modified="2015-04-29" version="1">MIVAMEKDHVQVVSMSDDERKKGKYSPLTLQKALEAMNQDGLVVLKNVVDTDHIATINERMCLDAEKKRVDPSQTFNHGVKSNFLQRPPVTESSYLFEDVYFNPFLLQLANAYLGHTPIWNWLTSNVALSNTSGLRQPAHKDCAFAHPQYPYYFIANIPLCDFTVETGSTEFWLGSHAHASFREQVIATTPEQIVEYGRLGEPLPAITDEAKEARRAIRPPIQPECGPGDIMIRDLRLWHAGMPNESDKHRIMLGLGYQSPHYPNYSQRCHLPLSQQDFFMRSSAGGTVEVRANFYEDGEFDRLTKDTWFQLRPDYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYW2</accession>
    <name>A0A0D2AYW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232114.1">
        <property type="nucleotide sequence ID" value="XM_016383491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYW2"/>
    <dbReference type="STRING" id="91928.A0A0D2AYW2"/>
    <dbReference type="GeneID" id="27336254"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09171"/>
    <dbReference type="HOGENOM" id="CLU_004131_2_0_1"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000033">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="250"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="381"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="662"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="764" mass="84500" checksum="E1C19F4B0D5BE3D1" modified="2015-04-29" version="1">MADSMEVDADGPRGVKRTASEAGLPPETPRRIKALDQDVVNKIAAGEIIVAPMHALKELLENSVDAGSTIVEVVVKEGGLKLLQITDNGHGIEASLKDDLPILCERFTTSKLKNFEDLLSIGTYGFRGEALASISHIAHLKVTTRTVNSSCAWQAFYADGRLAPSKPGQSAEPKPTAGRAGTQITVEDLFYNIPNRRRAFRSPSEEYAKVLDVVTRYAVHREGVAFSIKKYGESGTGFSVAAAATKIDRIKQAYGGAVAKELMEFKVQDDKWGFKASGYATNANYSVKRTTLLLFINNRSVESSAVKKAIEQTYQMFLPKGGHPFVYLSLDIDPGRVDVNVHPTKREVHFLNEDEIVELVCDNIRESLAKVDTSRTFKTQTLLPGVTPMTPLNPRARASESTPPTDGSAPNRPSTTKKPYENNLIRTDSKMRKITSMLPPALLTTTSQDGPPATGGVRYSTTDREQIQIRLSSVKNLRAEVREAMHDGLTEVFASLTYVGVVDITRRIAAIQAGVKLYLVDYGMAANEFFYQVGLTDFGNFGLIQLQPAPRLRDLLDIAAEYQIESAADCAHLDKGQVVEKVYDQLMSRRQMISEYFAMELSDDGTLETLPLLLKGYMPCMAKLPTFLLRLGPFVDWTQEEPCFKTFLHELASFYVPEQLPRRKSNDRNRATTLATASEDIMTGTEPGGGSASNQEDGDDDDDDDENEDDLDVMTENRRKELEHVLEHVLFPAFRSRIVATQSLLGGVMEVANLKGLYRVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZP0</accession>
    <name>A0A0D2AZP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_09469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232409.1">
        <property type="nucleotide sequence ID" value="XM_016383786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZP0"/>
    <dbReference type="GeneID" id="27336552"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09469"/>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="20"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW12193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="502" mass="56131" checksum="DFAB4014B1F65005" modified="2015-04-29" version="1">MAEQKTSHPRSWKGWLWDSADVSKEERLFLLKIDTSNITNAFVSGMKEDLNLYQNQYNYIVVSWTVGYIIGQWPSNFILTRVRAHIWIPFLEVGWTIFTFALAGAKSYSAMLGLRFVVGLFEAGYWPALYYILGSWYNKRELGKRNGILQSAVSIAPIFSGFLQAGIYNGLNGHAGLAGWRWLFIINGVISFPIAVLAFFCLPDTPFTAKPGWLFTERDLEIARNRMSLAGRAPEGKPYTFEVILGYLTSWKTLLFTLIFTMQPFGTQPFTAFVFWLKAHNKKGQPPVYTVAQINEYPTIGNGFTAAYSLLAVWISDGPLRGRRWPIILFSNTIAIVIFVLLAVTPVMGPFQHRAPLYIVSSIGGACVPLTMAWMAELISNNAEQRAFTAASMNTLQYTFSAWIPLVWFQQVHQPYVTAGNRAAAVVAGFNIIVFTTIAILAHREKIRNKRNGQLETEVSSVESAAADSTGAEVLKEHHVGVEHEHEHGGEKKASGLKVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0F1</accession>
    <name>A0A0D2B0F1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232416.1">
        <property type="nucleotide sequence ID" value="XM_016383793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0F1"/>
    <dbReference type="STRING" id="91928.A0A0D2B0F1"/>
    <dbReference type="GeneID" id="27336559"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09476"/>
    <dbReference type="HOGENOM" id="CLU_031980_0_0_1"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="65579" checksum="284B9F2D783189DD" modified="2015-04-29" version="1">MVAAPTKAQPASIQKGGRTESTTPPSTVSPETTPDKPRDRSPTRLKRTHNKVRTGCLTCRYAVRIMLATLSPRDEGHPRCQRCAKAGRFCEGYTQPKPSSAFDPRPNAVPVSHEVTSNFHRATTIHFFEDSDFNRPTQYFLECTAPRIASYFAEMMDSIIDDKSMVNQINMQAWTFWNRLVIQASETNACIRHSLAAISSLHEWLEFTKRTPWQNQSFTLHYTKAIAEINQDHGKLPLEIILVACVLFAHCDFLMGASAAGLTHLKSGQKIILESKTKQAHLSPEVRQLIEPVIEGFILKSANYRLTETSSVEKGTNAGTTYSLPEMPKVFRDLDQSNKFLQQALYWVLLLELGQPNHLSSMAPGVRKYVADWATSFGQWKVTYELDDPVLKDWQLLLLAHHRMALLILKSLPPENDKIYSRAAADFRIMFVQIRTFLRGGYTELLHEEHNDDLVLKVHLGFIAPLFFLATECRARDLRHSALDALRDLKVVEGHWNSCVAYAIAKTATELDEKASQGNPGKTVRIKLDSVDRWKDGTMTLKYYKVGLGNVVTGEAELEAITEPACHDEVNMQWVSADYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B239</accession>
    <name>A0A0D2B239_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232886.1">
        <property type="nucleotide sequence ID" value="XM_016384263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B239"/>
    <dbReference type="STRING" id="91928.A0A0D2B239"/>
    <dbReference type="GeneID" id="27337031"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09948"/>
    <dbReference type="HOGENOM" id="CLU_039765_0_1_1"/>
    <dbReference type="OrthoDB" id="4388755at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238782" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="81"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="369" mass="41038" checksum="8C905E9CB1AECA41" modified="2015-04-29" version="1">MVSLSVALIALLSLQSRASQLPERRSPLFPRASSPSSSKCDLYVVSGQDTTKFEHYTFSDFRALSNYSINEPPSVTAEEDQGQENITSPYFAQPPFSDQWEIRRGIRNAESTVPMIYSASNVYITKDPGSGGSETYLTLRTTRLQDFQSVVQLVSVPDLLHASMRTRMKILPDGKDGKNVARGAVVGFFTYESDTQESDIEILTRDPLDTVQLTNQPASSTTPGASFDSTIPHGKHWTDWTEYRIDWFPGRTLWYLDGKMVFNTTDSVPTDPSNLMFNLWSNGQSFSGTMRVGREVYVAVQWIEMAYNLNGQGQSSNQTDGKTQCSVDSVHTKGVPEVIKSSSAKHRAVSRLLDTINSVLFVLIACYCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B371</accession>
    <name>A0A0D2B371_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233251.1">
        <property type="nucleotide sequence ID" value="XM_016382548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B371"/>
    <dbReference type="STRING" id="91928.A0A0D2B371"/>
    <dbReference type="GeneID" id="27335305"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08222"/>
    <dbReference type="HOGENOM" id="CLU_058851_1_0_1"/>
    <dbReference type="OrthoDB" id="5371334at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="44"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="319" mass="34926" checksum="45C48305441FAB2D" modified="2015-04-29" version="1">MASTNSNTRFTPFSLALQNGAIVTGIAHIPSMTSTTHTHSKPLIVGIHGATCTAQNFDISEDYTASTVSAALGVPFVAFNRPGYAGSSPLAPFDEATSYLREDGNWEHNFILPALWNHFGVTNGCNGIVLLCHSMGVPGSMVAAALWSQENSPKYPLRGLILSGFGVETFWTDQPAILEGHGPSSSELSFPLAVKETLMLSEPSLWCAEPKVRSLVGPQTVPMKRDELIDMGFIWPQYWRSYAKSVRVPILYAVGEHDWLWKGTKELVHEFGSCFPICPRFEGSIVQGAPHALEWSSVSLGWYARCFGWAIEVSTYPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B3L3</accession>
    <name>A0A0D2B3L3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233471.1">
        <property type="nucleotide sequence ID" value="XM_016382768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B3L3"/>
    <dbReference type="STRING" id="91928.A0A0D2B3L3"/>
    <dbReference type="GeneID" id="27335525"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08442"/>
    <dbReference type="HOGENOM" id="CLU_471846_0_0_1"/>
    <dbReference type="OrthoDB" id="4115096at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="586" mass="65164" checksum="6208BADEA3C414B4" modified="2015-04-29" version="1">MSICPDNSTECLLRALVSEVNASRALLEDILDSTSHFNWDPLNFAFTAAIGALALIIACITVFQSLLAAGPGRIKASKLAIGPYAASAKSRFDYTELSLRTVVYVPSINHVNEIYQVDRAIPDHACCSKYDPSAGKSESSASWLRLLVELGLSDPRLWTVVARQTDVLPADISAAPAAGSVRFLAHLAAVADENCTIERHPNGRFVTVIGQASQLTFRDHPVLGSVAMYETYRESPSYARRHVKKTMTEYRPVTGIRDRHSIGIMETAGMLNLSHGLVKCRHLGYAVTEGLIQLSFGLLLQRLTSHCTHGHLSDNPASILFGSRGTNGVRRARGYMYFLLFFTSVLSVVRAFPSGLLKLPEAIRDISRLIPAWTTSPNDVIFEINNVVRTYGGNFQEIPMAAYTFYILGARARHYSHSEWLEDPPGAGWCTNSMHSDFRKDEDDLVYGEEVIQLCFQWASLINVQNKSLKEFLPEKEQLLASLYLVDDWLRRRNKDDIICAALFLIQDTAVERELRSSQLSSPAIDLRASQVSQNDISEQVDIARLRPMQVMLTYRAILLGALLELSTDTSCIVDESFQDTIVKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5I6</accession>
    <name>A0A0D2B5I6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234399.1">
        <property type="nucleotide sequence ID" value="XM_016381297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5I6"/>
    <dbReference type="GeneID" id="27334047"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06964"/>
    <dbReference type="HOGENOM" id="CLU_175704_0_0_1"/>
    <dbReference type="OrthoDB" id="10444597at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="107" mass="11755" checksum="4D833CFBD3ED50F8" modified="2015-04-29" version="1">MSLTSTPRVQIGSQHAGTGLHRRSGRSRNNTSSYTVEIFAMSTDQMDPLILGVVNQQTRQMSSSILFAQLDTIAALFQQHGTPIHVPISSIESTDLAFVGGQFERHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B5X2</accession>
    <name>A0A0D2B5X2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_06841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234276.1">
        <property type="nucleotide sequence ID" value="XM_016381174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B5X2"/>
    <dbReference type="STRING" id="91928.A0A0D2B5X2"/>
    <dbReference type="GeneID" id="27333924"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06841"/>
    <dbReference type="HOGENOM" id="CLU_519742_0_0_1"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000503">
        <property type="entry name" value="Calcineurin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="451"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW14060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="524" mass="57096" checksum="DD3C6DDB827A36AF" modified="2015-04-29" version="1">MAGGMPRRRKANGCRTCIMRHVKCDETKPNCNRCLKARRRCLGYPVTTDASPVAFLVMAQGSNRPECDAKARRAFQFFYEACASSLSQHGNTAVWTRMVLQTSHYEESIKHLVIAAACLGLCRRFGVSSADEEITFLFHHGKALALLSRGQWHNPSVILLACLLLVLCGQLQNRDDMAAQHAKAGKKILASYYGENSHPGTGTDPLIDEIAMIFSRLNFDTPSPIQTAGLPTDSPPVSTTSSPGSLSAKRNRSGLSLDFSSLPPMSQPAPPSNTLLITRLEDNKIFHPASLATIRQHINEIAPLNSFSPLKSLCRIICSFYDTDSAIRVRQAIDGTAILGSSVAKCYFGEPTPIGDEKKYLDRPDAGRLFFISPPPSPPVGWEMKHEDPPNREVHAEDLASKLQKLSGKLGTATATATVDEENNEDGESKPQYSAEALQRLKEYRARAALPGGVSTDNSASAPSPIKHRSRSSTLIYDPKAHGDSPGLPAVMLEAEDESDVELEDSGTKIMAHTPRPPVELMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6Q6</accession>
    <name>A0A0D2B6Q6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_07147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234581.1">
        <property type="nucleotide sequence ID" value="XM_016381479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6Q6"/>
    <dbReference type="STRING" id="91928.A0A0D2B6Q6"/>
    <dbReference type="GeneID" id="27334230"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07147"/>
    <dbReference type="HOGENOM" id="CLU_014722_3_1_1"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238819" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="357"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="558"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="678" mass="70929" checksum="ADEEEE8E4DA5F1A5" modified="2015-04-29" version="1">MSALLTAGLITALAASPVSAFWRLPCKSPIVVERADPIVSPGKVASHLHTIMGGNAFDFTMDDNTTRSSTCSSCTVIGDDSNYWTPTLFFQHQNGTFESVKQVGGATVYYLQRKGDGETLKAFPPGFRMLAGDPFKRSGGDDFASQAVSYNCLNYNGPAKPETGMFPNYNCPDGLRAQVFFPSCWNGKDLDTPDHKSHMSYPANSYNSGACPPDFPVHLISIFYEVIWDTGKFADQWYGDSQPFVWSMGDPTGYGGHGDFIMGWDPDLLQRAVDTCTNDSGRVEDCPEFKLIPDSQAEGCRIASKVDEPVSGLLDALPGCNAVQQGPEPAKPQTDCGAPTTVGAGNATFFTDLTSKGWSYTGCGTDNYYNRILTGTSESNGQMTNEACVAFCDSKGFSVAGTEYSSECYCGNSIPTSGMPVPGVVGNCQMKCSGDDSEFCGGAGLISLYQKCTGSECVNTGGAGGGAGGSSQVISTSSSAPVSTTTSPTSSSAAAPPSSSSSSSSTSSARASSSSAVATSAPPSSSSQATLTTLTTSSSSSTAIASPTSTTPVSSNPSWSYSGCFTDTVFPRSLPEWSNFNGPTMTNDACISYCDKAGFPVAGTEYAGQCFCGTSTPTPQLTEDKCNMACTGAADQVCGGPGALSVWNKKTTTTKRASAAVKRHASHLRKHQLRREMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6Q9</accession>
    <name>A0A0D2B6Q9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_07347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234779.1">
        <property type="nucleotide sequence ID" value="XM_016381677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6Q9"/>
    <dbReference type="STRING" id="91928.A0A0D2B6Q9"/>
    <dbReference type="GeneID" id="27334430"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07347"/>
    <dbReference type="HOGENOM" id="CLU_039228_7_0_1"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF7">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW14563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="381" mass="43328" checksum="A513B21898C248E3" modified="2015-04-29" version="1">MSVLRSISLAERQAIKRDILASNDTFVAALPKVELHVHIEGTLTPSLRWKLAQRNGMTLGLKRTGTVYHTLEQLEASYELIVSRPGHSFNHAEERFTFFEAYYDGFEVLVTKQDFYDLAMNYFEHAASMNVRYCEPFFDPQGHTRRGVSWATMMGGLKEAQLEAERRLKVKSKWTMCFLRDMSPESAMEHLEAALPYRDMIVGIGLDSDEYLRPPSLFEAVFSRARAEGFHLTCHCDVGQQDTHDHIRQVASTMGGTGAERIDHGINAAEKPELVELIRRNGLGMTICPWAYMRHEPLDEIFPRLRVLYDAGIPVSIASDDPAYMEDSWLIHNMLVAKKMCNFTNEDMEKLTRNAVSICWAPDNVKSDILQELEAVVAAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B6W2</accession>
    <name>A0A0D2B6W2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_07198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234631.1">
        <property type="nucleotide sequence ID" value="XM_016381529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B6W2"/>
    <dbReference type="STRING" id="91928.A0A0D2B6W2"/>
    <dbReference type="GeneID" id="27334281"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07198"/>
    <dbReference type="HOGENOM" id="CLU_024451_0_0_1"/>
    <dbReference type="OrthoDB" id="2117459at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
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        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX-associated" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="163"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="357"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW14415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="760" mass="84293" checksum="1BBCB7C8BBD1F3F7" modified="2015-04-29" version="1">MGEEVLSTAQSAALFDILTHYNTYAEIREFRNPGSLAQYGPPFNHDTAKPSTSPALQALVSKYLLNLPGLNNLPEKWWKVQCHTIIENLEKANLSESYDKGAIGSRKTVATATSALIEYPVRGTFGGIPKKTDRVAHYDTGRAEDLSRAFRDFLNDAVYGDVLDEMVQKTAQTDRLEDHPPLTKAVHEFVLVNLASFMHYTLILSPKGQYLLKLIDNANKLVPYLVIKQTLKIGNVATMINAMVKVGLAKMSVASVTNWIGLTSNSDEGMNLMQTIISTVLNWDIRDLESRAAKLERERAKLGKEQLHTLKAYTTKPQHEQDRIRRQSQTQSISIVTAILRDSKCSSTELTEHHHAQALEYLSIHLSVRDRKQLIQVLCRSNPDHLTTSVREVVDAYEPVIRRLHKAVDLSGTVNDFEYFLRDLIKLGRIHTDKTGHSVVPTVGDFVQLLRKHQRSTHVFMHQCCKNDKELTGWYLDWAKQAASQFRRDHPGDGHPASKAQGPGNLTPDLHRLFGSLDKSTQDRIVPILDSHSSYLEKMHAQSTARLQSVIHSRPSRSPAIAKLFAGTTATTNNNNYYYYNNTVVHASSTPPSRASSPPPDRPRSVPPPEPQPSETSREIRERPTTPKVSSSSSSSSPGPGSFLARWQALLDATPITPLTQSGPPKAASSPEVVRASATDVDGSRLVDFGPEEASGAKIRVEGGGGGVGGSSNKYSTSTSSSKSPSSIHEARERQRQYRVIVDAMGQEFRSLLAERSRYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7M4</accession>
    <name>A0A0D2B7M4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamyl-tRNA amidotransferase complex subunit Gta3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234901.1">
        <property type="nucleotide sequence ID" value="XM_016381799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7M4"/>
    <dbReference type="GeneID" id="27334552"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07469"/>
    <dbReference type="HOGENOM" id="CLU_085810_0_0_1"/>
    <dbReference type="OrthoDB" id="5522061at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049545">
        <property type="entry name" value="Gta3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20978">
        <property type="entry name" value="Gta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA amidotransferase complex subunit Gta3" evidence="2">
        <location>
            <begin position="64"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="219" mass="25316" checksum="11CEF4F547551AA9" modified="2015-04-29" version="1">MPRIRVPLRIRPELVGPERSPQRDRFVKVVKDIEINPRISELLQTPTWSVSSLMPSPDQKAEDSSEISREKLHHLLRLSALPPPASKQEESSMLNTLRQQVHFVKEIQKVDTTGVQPLVALRDETAEARSERQFTRSSLKEFLDLEEKRGKNGTIRRNKEVEPRRNILTKPRQFQAEHTDDRLEDPFNLSNDPAAHKSDKKRGQYFVVRRSTKDAAQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7Y7</accession>
    <name>A0A0D2B7Y7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_07765</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235194.1">
        <property type="nucleotide sequence ID" value="XM_016382092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7Y7"/>
    <dbReference type="STRING" id="91928.A0A0D2B7Y7"/>
    <dbReference type="GeneID" id="27334848"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07765"/>
    <dbReference type="HOGENOM" id="CLU_015166_5_1_1"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="106"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="203"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW14978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="300" mass="32549" checksum="E4F1CC38BA01F0DD" modified="2015-04-29" version="1">MATSAADGDKTKAKPSALRSIIAGSTAGAVEIAITYPFDFLKTRSQLNRHLPTEKKLPLPPFPSKEWYTGCTTAIIGNAFKAGVRFVAFDQYKHLLSDEDGQISGPRTVAAGFGAGITESLLAVTPSESIKTQLIDDRKRAQPRMRGFLHGSSVIFKEKGLAGFFQGFVPTTARQAANSAVRFSTYTSLKQFAEGYVAPGEKLGSVTTFALGGLAGVVTVYATMPLDTIKTRMQSLEAKQLYRNSFNCATSIFKNEGILTFWSGALPRLGRLTLSGGIVFTMYEKTMELLDSLDPDRKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B883</accession>
    <name>A0A0D2B883_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016381999.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="116" mass="13373" checksum="33C46654C1F4C2DD" modified="2015-04-29" version="1">MSRSNKLAPEANRILFVKNLAYNVDSESLWSLFTKFGGVRQIRLGNSTTTKGTAFVVYDEVLDAKQACDKLNGFNFMNRYLVVLYHQPEKMKVEAKEDIAARQENLERMKREHGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B933</accession>
    <name>A0A0D2B933_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235386.1">
        <property type="nucleotide sequence ID" value="XM_016379559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B933"/>
    <dbReference type="GeneID" id="27332298"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05215"/>
    <dbReference type="HOGENOM" id="CLU_129963_0_0_1"/>
    <dbReference type="OrthoDB" id="4113403at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="143" mass="15901" checksum="9052357A304C6D92" modified="2015-04-29" version="1">MNRFSKAIKFFTPENIIRLLLLVVGAVAFGLSIAVGHIGRRKAVFTVLPVAYATSTVCNALIFLSSLRTFRSKVISKRLRFRDEEKDVKAPSLLFLAADTLGLFTFLALYIWSTIETANAENNYGWYPIMLMTYSGAGALVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAA1</accession>
    <name>A0A0D2BAA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cutinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_05968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016380307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAA1"/>
    <dbReference type="GeneID" id="27333051"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05968"/>
    <dbReference type="HOGENOM" id="CLU_705976_0_0_1"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238990" description="Cutinase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW15918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="43194" checksum="EFCE8E6A0EFD02B0" modified="2015-04-29" version="1">MKLSWFALLSTTVILRANLVLSQDDSSNPGVNPDAQVDPTTPSSLSTQAESNARGDPNVAVVLSTNAHSRRSSGGEPVPEEGSKNDLVARQEIVYAGIPHIPDNCSDIRVFSFRGSNEPYPGRGGAMLGTLCALIEPKGLSCDYEDVDYPANISWSGLYCSSAHIGTTAGVNQMTDYVQKCPDSRLVMLGYSQGANVASDILGGGGGELFGCQQAPNPPLSRDIKPGSNIVAVVTMGNPRNTADQPYNLGRGSNYSGELGRSGQQLVDLNKYEDVMANWCNYGDPVCAVGSEPTNLTAHWDYYDEYSYVASEWVVATVMGYTDERLDLTLDGQNQSVVLVNKTSDSSSGNNGPANAHNSSGNVSTGSGNGSNGSRGGGGDEDGAFSFRSNAAGGLSVLMLVALVTAGLSFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAZ9</accession>
    <name>A0A0D2BAZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor BYE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_05835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of transcription elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BYE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236001.1">
        <property type="nucleotide sequence ID" value="XM_016380174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAZ9"/>
    <dbReference type="STRING" id="91928.A0A0D2BAZ9"/>
    <dbReference type="GeneID" id="27332918"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05835"/>
    <dbReference type="HOGENOM" id="CLU_009292_0_0_1"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21538">
        <property type="entry name" value="SPOC_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055499">
        <property type="entry name" value="DUF7071"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR BYE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23257">
        <property type="entry name" value="DUF7071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="74"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="10">
        <location>
            <begin position="272"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="701"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="735"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="764"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW15785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="858" mass="93574" checksum="DFEBE2A1EC73B3C8" modified="2015-04-29" version="1">MAGKRCHIHLPRVAQASSKNPLTDMQPDEPRRSGRATKGQYTKDRDIQEDAPKKKGKEKASKAKAVEEEEPEETIRCICGTYEEEEDVPRAMICCDKCAAWQHNSCMGLAEDYEAETYFCEQCRPEDHKDLLAAIARGEKPWEEALRKFEEKTKKKGKKGRKSGAGRASEVPSVASQEVKDQTPQPSSTGQKRKLEDSPVVPEVKVSRIQDFHRSYLTHRQNKKARGTPVADTNTNGTKSATPASRPSETPSRRVSKTEYPVPSDVKELDNVRKQAATTLIKLVEQQIKEATKQGEYNLPSGSSAQNVANQMGLNLEAALYHIHAGGSGEPNEAYKAQLRSIPFNLKKNHALAVQLLNGDITPQELAGMDPKDMASEEQKKKDAATMKELEKQHTIVEEQGPRIRRTHKGEEYVDESRQVAAESESSNAPARRPSAMEPAEGDAHSPDVKSPSDIADRPKPTVDTKRQSSANFDIAKVWSNVQGSPDTDGQRFGELPQESPGVAVREPVGPGAKADADIDALLKDEEAESPPYSPQETAAADGTVWRGNINGGNLGRFHAIAKYAAGATPESDTLRMTYDDILPADITIGGRIQPSKADEYLCGLEYSNTSDLVIVYMPEPQNSPDQQEFDKLFRYFKTKERFGVCVQQQTPAIKDIYLIPLNKGQELPTFVKKLETDFPDPAQERMLLVPIVIKNSELPHMKGVNHDGSVDSPLTRGPAVAQTPITPHEGSFESQHASAAAYSQSPAPAGQYGTNGVPNQSFAPQGAPYPGYGQQQPPPPQLPQSPAMANAQKILGPMAGSPAVVQLCAQAPNAGEMEFKIIKECIERNPEAANRLDVLTTMLQETSVAAGGSGGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BB82</accession>
    <name>A0A0D2BB82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236091.1">
        <property type="nucleotide sequence ID" value="XM_016380264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BB82"/>
    <dbReference type="STRING" id="91928.A0A0D2BB82"/>
    <dbReference type="GeneID" id="27333008"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05925"/>
    <dbReference type="HOGENOM" id="CLU_665893_0_0_1"/>
    <dbReference type="OrthoDB" id="3021074at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="450" mass="49706" checksum="2345EB507D803083" modified="2015-04-29" version="1">MSWNQYDNVTTINCVYPISGAYGLLPRVLYYLTLVAAIFGRSREWLVIGALVSALTYAGTSSVHMMTLVRSRTGAFDLDILAAWAVLSTGALGYIGMMHWSSTMRNSRARMVMILWGALVGMGLIFGRALLFDTPASPGEKACWSTTATSNHYYYDSHSHNHNNNNNNATDGSGSMVLLTQVYQLQGSEFNCTYTCFGITKPLRQWSEIMAVPSQLVHGRYSSLSFVLVGPIQFAAYAAVSADSASEHTPSALCTRLVMKHLLRDGGYGRAAAAAEDLTKVVYKASMESWYGGYFVFIGYIRRVRWCWLKVRWASVLLPWLALSFAIDVLCLPLMVANIVLNEVTLLGGGFPVNEANMNIGQWGPVVSSLLVVIAACVNKGTEWWEERRTRRKKCRECEPGEGDVVVEEVTVVAGKHSDDDDDGQVLGVVKPKMVHVHTLQDMEDLRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBA7</accession>
    <name>A0A0D2BBA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236514.1">
        <property type="nucleotide sequence ID" value="XM_016380687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBA7"/>
    <dbReference type="GeneID" id="27333432"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06349"/>
    <dbReference type="HOGENOM" id="CLU_064039_0_0_1"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052358">
        <property type="entry name" value="Aro_Compnd_Degr_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563:SF2">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="12"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="309" mass="34949" checksum="0FCEFEE6C32D302E" modified="2015-04-29" version="1">MSKVRLPSQSWDSHMHVFEPHSLDHDSAPYSPIPSDLPHALAFEASLGLRNIVLVQPSCYEFDNTYLLRALKRLGPQRARGVVAFDPLTITVPVLQLWHQLGVRGVRINLKSVNETMDRLAFEALLLRYANAVRPLGWVIQLYIPMELATWLEDLSPALDVRLCLDHFGCPDLSFMSSAISSSHSSSTAAQTPVDPYEIPGFRSVVNLLAQGNTYIKFSGAYRLSKDSHMRDLAPIAKELLRVAGPTRIVFATDWPHTRFNGLDIRPFVDQCVQWCDNDHVLIDRIFRDTAEELWDIREHGSDSRHANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBP0</accession>
    <name>A0A0D2BBP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_06480</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236644.1">
        <property type="nucleotide sequence ID" value="XM_016380817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBP0"/>
    <dbReference type="STRING" id="91928.A0A0D2BBP0"/>
    <dbReference type="GeneID" id="27333563"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06480"/>
    <dbReference type="HOGENOM" id="CLU_102602_3_2_1"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW16428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="136" mass="14236" checksum="2529C1A8A8FA00BD" modified="2015-04-29" version="1">MSSELTYAEVSKHSTKKDLYIVVHDKVYNASSFVDEHPGGEEVLLDVGGQDATEAFEDVGHSDEAREILDGLLVGNLKRVPGDPAPKIGATDKISAGPGGKSDAGTGLGVAMYIVLLAGAAAAYFGYTYMQSQEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBQ5</accession>
    <name>A0A0D2BBQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236221.1">
        <property type="nucleotide sequence ID" value="XM_016380394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBQ5"/>
    <dbReference type="STRING" id="91928.A0A0D2BBQ5"/>
    <dbReference type="GeneID" id="27333139"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06056"/>
    <dbReference type="HOGENOM" id="CLU_068279_1_1_1"/>
    <dbReference type="OrthoDB" id="4141102at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="74"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="315" mass="35379" checksum="082FADF13FF085D0" modified="2015-04-29" version="1">MADPTEEVMTAPAEQVMAESTEQAMAEPAEQVMREPAQRAASPASVISDWQTDDQMEAQEMSSDEEPQSFTISPLVTVIVGKRRKLYKLHRAQLMDKSPFFAACLSSGMVEQQKNEVVLPEDSCRGFDIVADWVYNKSEWDTVTMEGSMLRAYVLADKYGMPSLQNALIDKLGHFWTYKTRIRPARVLWLARNAMPECPLYRLATEQLAYELKKEGKHYGDKQDTTPPTMVKTEPNAEPQPTRTVDADVDRAKELTKALAHPDLSTKLLWGAIHASRSTRPPAKASVFYRVPVNKPRKRVAVEDVDSPDAKKHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBR7</accession>
    <name>A0A0D2BBR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SUR7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236246.1">
        <property type="nucleotide sequence ID" value="XM_016380419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBR7"/>
    <dbReference type="STRING" id="91928.A0A0D2BBR7"/>
    <dbReference type="GeneID" id="27333164"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06081"/>
    <dbReference type="HOGENOM" id="CLU_059603_2_0_1"/>
    <dbReference type="OrthoDB" id="5419460at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28484" checksum="CCE5D644CBE58ABE" modified="2015-04-29" version="1">MAGRSLFSFVSLILVAGALLFMFLILLAGAVDGDPVNKFYFLQAETGNIPGAPPVSRWSYWNVCNVVNGKTACGDEHYSDVHPAFPLDPSSHREFDTDVNVPRNFVRHHGYYFYMTRFMFAFMLIALFFGVCALFTGLLALCTRLGSYLSGLLTMIAMFFQAIQASLMTAAYVKGRDNFRRNGQSAHIGKYAFGFEWAALACFFLATVLFCVGGGARRDSTPKTAGGRRFGGLPFRGRRTRSTRSRGSFVHDKEYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCI9</accession>
    <name>A0A0D2BCI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236909.1">
        <property type="nucleotide sequence ID" value="XM_016378232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCI9"/>
    <dbReference type="STRING" id="91928.A0A0D2BCI9"/>
    <dbReference type="GeneID" id="27330964"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03881"/>
    <dbReference type="HOGENOM" id="CLU_894386_0_0_1"/>
    <dbReference type="OrthoDB" id="3928876at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="311" mass="31719" checksum="82C0064A43FBB7DB" modified="2015-04-29" version="1">MAPEKPVPSSSSSSSSPGGETDSSLSRLAGRLQGAITKTVTTSGRAIDRFLPPQRRERWKDAIVAFASKRPYLAGFLALQIVMNGVPLVLFACTTVSIFIFSLLTGILVGILGGLLFVVPAIGLGLLLLMPLLFFTTAAAVCVWIWAVAAYATVNWLGSGRREDTAAPPQSGGTTKTVGANGANGATPPTRQGALGQPNPVPTTAVGGGNGSGLQPSPEMNGGGRHAEQPATTSPPPPPTSQLRRGEVQQLHAVDSPSTKQPDLDTSMLGVQPDSSSEGTQSHGHTPSNSNSSTSTSSNGSNGNSGAIDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BD89</accession>
    <name>A0A0D2BD89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236771.1">
        <property type="nucleotide sequence ID" value="XM_016378094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BD89"/>
    <dbReference type="STRING" id="91928.A0A0D2BD89"/>
    <dbReference type="GeneID" id="27330826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03743"/>
    <dbReference type="HOGENOM" id="CLU_039326_4_0_1"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF274">
        <property type="entry name" value="ALPHA-CARBONIC ANHYDRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239045" description="Alpha-carbonic anhydrase domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="72"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="309" mass="34738" checksum="71E54224FFAE13C8" modified="2015-04-29" version="1">MLSKIFLASILTTAALGCADHSNHLPHPHARRDVPPEEVDPGRDVNDWTYEVSSDWAYINPSEPNLPVNKYLDWSFSAHDIELHTDILGIGTEYALCQNGTQQAPVGLTSDQGFSEVHEPVFGNYEGNVTGTYYNWGYGPAFTPMYNKSTIYSLPNLTFDGNTSYMVGWHTHAPAEHPVNGKRSMAEIHFVHADTDGNYAGVLAMRIDPSGDIDSPFVSQWPWTIGFNETRQLTNVQQDLDLALQEVVYFDNFWTYMGSLTVPPCKEGIRFFMAEQVLYVSNAQMQRILGMSAYSTRIEQPIWLQGVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDU5</accession>
    <name>A0A0D2BDU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237339.1">
        <property type="nucleotide sequence ID" value="XM_016378662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDU5"/>
    <dbReference type="GeneID" id="27331397"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04314"/>
    <dbReference type="HOGENOM" id="CLU_388849_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="710" mass="79352" checksum="F847D8FB98ED1145" modified="2015-04-29" version="1">MDQSVQPDHDNGPVAEEWDQWLNSPLFISDSDLLPSQQDVVEEDPAEMQPTNANVGGLVNTSDNKEALNSGTASTQLGSLEVGFGFDDTFTLDVWFGVNNEDSCSINTFGGNTVTSGDTLSHPLVQDISEINESFTIPQEPLSQEVRGSENSAGCDLHSNQKLLGGSQLSTEPQQLTLTDSASSEPQPRGQQRANRSNTQAQNPTKFVPKAAPRKPTETDKLLGLSYQRYSLDQPKTPRRRDHKNILSLRNSRGQCIRCIYRHRKNTGAISDFLKSKTPGQKRRSVAFDVYSCFENSFWGFEEPTLETWNLLQAITNLAASDETSNLSIFWRRCLTESGFQAPATFAMSSLLLAKPDYLRLLAPEQESFVRACRSHSSSCLLKIIDRVVRGQSFPNCGSSGRESLSESTVIFAMLLLGSMIHLSIHENALDRKAHDAYQFLERYLTETLRLIGPSLENSGYHNPGSSDWFVLQKINTRLTHCHFLPDESDLNSYQAFARFSGLRDLGSPNDYMALVPLSWWKSRNYPSLPGLTAGDLYNTLGLVCCCISDNTTRPSELLQKARRSWAGIRLFVGLLTDDIVAQIAPCRSLPHDSFFSDLISEWKFVLEFFEEIRPKHFKHFDLINYVGTWGDFLQGAYVCSLPVVLMSMRVISLDRLVTTLCVLSLYEKYRLAAIFLLRHPAGMDLVAKLLSIRHRVEEGALSGTVTGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF97</accession>
    <name>A0A0D2BF97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_11770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230210.1">
        <property type="nucleotide sequence ID" value="XM_016386078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BF97"/>
    <dbReference type="STRING" id="91928.A0A0D2BF97"/>
    <dbReference type="GeneID" id="27338853"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11770"/>
    <dbReference type="HOGENOM" id="CLU_003827_5_2_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="58"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="270"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW09994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46092" checksum="F4F8A7FED8751C9F" modified="2015-04-29" version="1">MPIVSNVNKRFRVYLTSLKEKLCPFDDGTVQKPINRESQMIDLISSFITKSDHYDRNHGPIQHRIGSEHTVTVNGLVSRPLNLTLDQLVEDFPQHRVTCTLQCAGNRRHTMRTRIKEVLGVDWFDGAVMNCEFEGPLVRDILLAAGVEEDGVMQRNVVPKHVHFANHGGKTQHDEWYGGSIPFARAMDLEMDVILAVKMNGLPLEARHGFPVRAIVPGVLGARSVKWLDSITVSDQESPCFYQQRDYKVLPPEVSDAKTAEEHWARCPSMLEMPVNACVAWPVSGSTIKLPASGFIEVLGYAVPQGCHGPVIRVQVSGDEGKTWTDAQLEHGGEHASKWTWVLWNARIKIESGEGKRIFAKATDSGGYTQTEERSTWNLRGVAYNGYEAAFDLTVIEEVDRPAVAARLDVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFU2</accession>
    <name>A0A0D2BFU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_05073</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238094.1">
        <property type="nucleotide sequence ID" value="XM_016379417.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BFU2"/>
    <dbReference type="GeneID" id="27332156"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05073"/>
    <dbReference type="HOGENOM" id="CLU_001883_4_0_1"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="158"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="646"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="1269"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="745"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1033"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1033"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1050"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1088"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1101"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1126"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1163"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW17878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1336" mass="145486" checksum="A6C1ECFD4C1BDDE2" modified="2015-04-29" version="1">MAGTGGKEWPMLGRGTLPRSRPTFSTRTATDDAAQLLRRSSFPALLDSQNQASHEHGDAVPDSSRPIPIPSGVSSPSVSRPQTASSTGAYGTFSHVHNVPERDQANGQADFAASMPHDTLTGSMHSASTKPENFTFNQVPVAPRTNGGTDKLGTFSGVFVPTSLNVLSILMFIRFGFILGQSGVVGMLGMLTVAYLINLLTTMSISAVASNGIVRGGGAYYLISRSLGPEFGGAIGLVSYLGFVFNTGMNAAGLIDCLYYVFGSKSGDWTNTIPEGPWWQYLFSTAVVVICVAICLAGSSIFARASNALLFVLLLATFSIPLSAVIVKPFYGKNHFTHFTGFSIETLKENLLPKFTKDAAGSQLHGKENYQDLFGILFPATGGILAGASMSGDLKNPSKSIPRGTLAGLALTFVSYTSVIIALAASVTRESFYRNVNVVQDTNVSGSLILVGEIATTFFSVLMGIIGPAKQLQAIARDSVFPGLAIFGQGSRKSDEPVLAICVTFLVAQLTLLLDINRIASLITMTYLMTFFALNVATFLLRIGSAPNFRPSFHYFSWWTAAAGAVLCVASMFFVDGLSASGSIAILLVLIVIIHYTTIPKPWGSISEVLIYHQVRKYLLRLKSEHVKFWRPQVLLFVNDPRRGYKLIQFCNSLKKGALFIIGHVIVTQNFGDSVPEARRQQAAWNKFIDFSKIKAFVNVAISPSIEWGARNIFLSAGLGGMRPNIVIFGFYNIQQFRAEQPLVDVPSPPPERKHSTLKKRRTSKSVMRGELPTDSCYIEKRTDVQSYVMVLEDMILKLKTNVAIAVGFGELELPKAQESITKKYIDLWPIQMSAEITSEADGEARNVLTTNFDTYTLILQLGCILHTVQSWKRAFKLRVAVFVEYESDVEDERSRVTSLLENLRIEAEVLVFWLACGSVKSYNFIVNGQEVDDETRDQADKVLEDEAWWRDLQTLRGHSQSGDVSAADVLSMTEDVEWPSSSFQGRREASVVRFEGLRKLLNRPTRKSSFGNLSNLGVSLSMRTSRLDDDMLSRHASHPSDSEDSGPLSEEEEEEEERDDSDDDDDDEYDDGADYEASSPSSSEDELLLHETDSADLRTSSKTKSSSKKSSLASSKRSRKKNKQSKQQGASESASSSSQKQPLHGDLVGGTNEDSRERNAAITGSSAATHMSTEALKVSSSKRPGSPTFTSSPLPETRLAGEEGVGPSIMFADEPHPRRQTVDEVDPGTGRSIYQRTTEDGTRSRTPAGFPSAASIPLSFNDLPSRAQHLILNELISQNSEDTAVIFTTLPAPVDGTYKSEADSLGYISNLEVLVGGLPPTLLVHSNSMTVTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGJ7</accession>
    <name>A0A0D2BGJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_04955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237976.1">
        <property type="nucleotide sequence ID" value="XM_016379299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGJ7"/>
    <dbReference type="STRING" id="91928.A0A0D2BGJ7"/>
    <dbReference type="GeneID" id="27332038"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04955"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF111">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_1G10100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="321" mass="34217" checksum="363E6C258C98471F" modified="2015-04-29" version="1">MAARIPARRTFSSTNMPKDVVYRPHEGKIGIVTGGSRGIGAAVARNLAAKGCSLLLVYTSDSSTEPTKALCEELSNEYGIVCTSVQADLSEPSRAAPHIVSTAKNNFSHPRTGAFQIDIIINNAGIAGNKLLNDPELGPIEETQFHKQYNVNVLAPLLLVQACQPYLPKDRSGRIVNVSSVSASLGCESQSIYAGTKAALEAMTRVWARELAENCTVNAINPGPVWGDMYSQAGEKFWKINQQYVDQAPLMNYKGGDAAIQSRAGGNPEEYDNIVLKGMGGKRPAFTDEIAGVIGMLCSEESGWTTGSVICANGGMKMSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGT4</accession>
    <name>A0A0D2BGT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_05035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238056.1">
        <property type="nucleotide sequence ID" value="XM_016379379.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D2BGT4"/>
    <dbReference type="GeneID" id="27332118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05035"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_5_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="893"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="932"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1032"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1107"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="277"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="603"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="896"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1216"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="818"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1187"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="818"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1193"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW17840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1495" mass="164816" checksum="88B7F29A73380396" modified="2015-04-29" version="1">MATRTCEPAADNNFGPVVAICARLFDFTLLFEQSILSIPTDSLFIIVAGWRMWHLLFTARKVNPNRLLSAKLLGIFGVIGATLTVLILEITDARTLTHASIPSAAVALVASAMLPALSYFEHVKSIRPSTLLSCYLMLSCLLSLPELRTLYLLPGTHVSAAALTVVICLKLYLLVLEARTKRKYLAPAYRDLPREMTSGIFNRSLFIWLNAFFWSGFRRPVGSRDLGVTDSQLHSEALHDAVRREWKRQQLDCCAPLAKALFRALRRSCLAPVPARLCYAALLFAQPYLIQRTINFLREPPTRIGDDIGYGLIGATAVIYLGIAISNMWYKHLVYRNIVVVRGSLVSVIYSESLVQLHNVGDPQAAVTLMSTDVDRICQSLAFIQEIWSRALELGVGISLLALQIGWISVMPVAVVFISGLLDAWITTSIGAQAGAWAAAVQQRISLTAGVLSSLKSVRMLGIEKPMSRMIQDERHNELRFQAKFRWSTVWLNTIGNAPTALAAAITFTTYAIRARVDNAQSLDVSKAFTSLALISLVTTPANELLSAVPFTVSCFGSLNRIQEYLVGKRRQAGKGSITTADYYPQDQTRIPPAEKYQSKPIARLHNVYLMDSSDEKSNIKGIELELYPSSLTIITGPSGSGKSTFLRRFIGDSQYVRGTLSAFSSKVSYCPQSPWLVTATIRENICGLERAPVDTRWYTEVVNSCCLTPDFVEMPNGDLTVIDGQVARLSGGQRQRIALARALYHRPKLILLDDVLSALDADTEAKIMERLLGPRGLFQRLDAAVVLVTHAIKYESAADNIISINHCRNISVRTDLQAHTRSKTPGNDETCSHGEKYDLQTDEDGLPKNQAPDRPGTNATGEGNYRLERTQKKKLDGDLADYIYCFKSVRGVWVLIFFTFASINTVCYYTSQVVLQWWTADNGQHETKWMPLYACLACGNLLFFGLLCWAMFLRLVPQSASSLHQILLDSVMGAPYPFFASEDGQVGTILNRFSQDLTVVDTQLPTGLLCTVIYLFWTFGSLALISTGSRYMAVIIPVVFVVLYMLQKVYLRTSRRLRLLDLEMRSPLYSHFLDTLAGLSSIKAFGWEHRFSEEMFDRLDTSQVPYYLLICAQRWLNLVLDLIVAGLAIIVVTMAVKLKGASDPSSLGLSLNNILSFSEILSLLLQFWTQLEVSLGAITRTREFARITPGEKAPEPDEEGSRGRPSSAWPEHGAVEIQNLQAGFTSDKMILEGISLSTRPGEKIGVCGRTGSGKSSLLLAILGLLEPSTESSLLIDGVDLRSVSRGIIRERIITIPQDVFLFDGSVRQNLDPGAAYTDTQLIAVLSKVKLWHLIQTQGGLDSAMRSDTFSQGQKQLFGVARAILKTSTPAIPVNTAICGIPNESHAAAAGGKVVLLDEATSNVDRETDAFMQRIIREEFATHTIIVVAHRLDTVLDSDRIAVLDGGKLRELDTPQALLAKEDSAFAALYRVSRCHATAVESEGASSATHGISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BGT9</accession>
    <name>A0A0D2BGT9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238439.1">
        <property type="nucleotide sequence ID" value="XM_016376869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BGT9"/>
    <dbReference type="STRING" id="91928.A0A0D2BGT9"/>
    <dbReference type="GeneID" id="27329594"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02511"/>
    <dbReference type="HOGENOM" id="CLU_070640_0_0_1"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249814" evidence="3">
        <location>
            <begin position="17"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="282" mass="30405" checksum="BDA53F301260647F" modified="2015-04-29" version="1">MRFSSTLLLLPLLVAADQQVAFKDQAAAWFDKAKAYLPNAAAVVPNPIDAGAAQVADSRVEKINLRNWKSKLGPKLDTEEEWMVYMTGGNKSCFGRCGKVDLTWNESVPLLAALPKTASSPPLHLGFVDCDKEAVLCTGWAASLPSIYHFMVPVQSNPPSKVPLRVIPLNLTSATVADIVAIPSNSKSRYLEEEEYTGLLHPFDGIVSQFGLLEPFGYLMWGLSTIPSWAMMIGISFFSRRIMNRRMQGPQAGTPAPAAAAPAAPRPAPAAAVAQGGGRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BH74</accession>
    <name>A0A0D2BH74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238559.1">
        <property type="nucleotide sequence ID" value="XM_016376989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BH74"/>
    <dbReference type="STRING" id="91928.A0A0D2BH74"/>
    <dbReference type="GeneID" id="27329714"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02631"/>
    <dbReference type="HOGENOM" id="CLU_012062_23_3_1"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="69"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="204" mass="21748" checksum="1F7C1DE46B03FE16" modified="2015-04-29" version="1">MPDEYDVKDEHSEPHGDGGEEEEEEEIAAMKRRVAEMESEAAKLREMQSQLETQSESGPREDREDVDARSIFVGNVDYSATPEEIQAHFASGPGTINRVTILLDKFTGHPKGYAYVEFSDAALVSQALVLNESVFRGRNLKVVPKRTNLPGMGRGRGRGGGARGGGGRGGFGGRGGFGGGAGYGGPRGGPRGGFRGRGRGYAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHA7</accession>
    <name>A0A0D2BHA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin subunit beta-1/Transportin-1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_02651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016377009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHA7"/>
    <dbReference type="STRING" id="91928.A0A0D2BHA7"/>
    <dbReference type="GeneID" id="27329734"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02651"/>
    <dbReference type="HOGENOM" id="CLU_008136_1_0_1"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000313">
        <property type="entry name" value="Importin beta-2 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000219">
        <property type="entry name" value="Importin subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="474"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Importin subunit beta-1/Transportin-1-like TPR repeats" evidence="8">
        <location>
            <begin position="521"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW18363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="949" mass="105537" checksum="16FE606F34776C70" modified="2015-04-29" version="1">MAWQPEEEALRQLSEYLKNSLSGHDRNKQKEAELMIMNARNNNDYVNYLTYIFTTPQLGQQLQLNTPSLFLIRYAGGVNLKNHIKLFYSNIPKDQLAYVKAATLTVLRDPNPQLRGFAGTVITEIVTQGGLLQWPEILQELLSLVDNSAGNAPAETQEGAMSALAKVCEDNRKLLDKEFQGQRPMTVIVPKLLEFATHSNPKIRVLALSTLKTFIPQKSQVLFSALDIYLQTIFQLATDPDVQVRRIVCQSLVQLVETRPDALSPHLDGLVNYILTQQQSSGNPDLALDAAEFWLSVGEQDQLRDRMGPYLNKIIPVLLAGMVYGEDEVFRLGGDENDADVEDRSEDIKPQFAQTKAGRGVKSEKEDSAPGTPQANGTPSKNDDLSDGEIEEEDEDEEWDDDDPENAWSLRKCSAAALDVFAVNYGVAVFDIILPYLKENLSHSLWPKREAAVLALGAIAEGCMDVVSPHLPELVPFLISLLSDEEPVVRQITCWCLARYSEWASRLESQADKQRYFEPMMEGLLHRMLDKNKKVQEAGASSFASLEEKSGEKLKPYVEPILRQFTECFKRYKDKNMYILYDCLQTLADSVGQEIAKPELVNLLMPVLIERWNKIQDDSREMFPLLGCLGYIAMAYGDTFAQFAAPIFDRCIKVIYSNLQQHMAFVSGQTVDQPDKDFIVTALDLLSAIIQAISPEKSAPLVQNSQPQFFDLLSFCMEDPTTDVRQSAYAVLGDCAIALFNTLDPYLAKLLPVSIRQLDLDAMPDDDSENSFNVLANVCWSLGEIAARASTSRISPFIEPLYRGLVTIIKNEEVPDPASENAATALGRLGLVCPEHLAPFLSEFAEPFLSSMSKVSTSHEKASAFLGFNNVIERNPQAMEASLGLYFSAIAQFPQKGKQGADYSEVRSSFGRVIQGYVGLIGQDGFRNFLGGLSAPVRQKLSDGYGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHU5</accession>
    <name>A0A0D2BHU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238426.1">
        <property type="nucleotide sequence ID" value="XM_016376856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHU5"/>
    <dbReference type="STRING" id="91928.A0A0D2BHU5"/>
    <dbReference type="GeneID" id="27329581"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02498"/>
    <dbReference type="HOGENOM" id="CLU_026535_0_1_1"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="273"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="360" mass="38760" checksum="DAB4825B94DD72D0" modified="2015-04-29" version="1">MSRPTVGILSADGASSGETLPLPAVFSSPIRPDIVQFVHTGMAKNKRQPYAVSEKAGEQTSAESWGTGRAVARIPRVSGGGTHRAGQAAFGNQCRSGRMFAPTKVWRKWHQKINLGQKRFAAASAIAASSVPALLLARGHRISTVPEVPLVVSSKAFEGAALVKTSAAVALLKAVGAGPDVVKVQKSRKLRAGKGKLRNRRHRQRRGPLVVYNPEKDGRELVRAFRNIPGVETSPVTALNLLQLAPGGHLGRFIIWTSSAFSALDTIFPGTKSNLVSNADITRLINSSEVQAVVKEPKGYATTKRSSVQKKNPLRNRQVLLRLNPYASQFSKEKLGQKGLGNQAKPERISSQALEVLHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHX3</accession>
    <name>A0A0D2BHX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_10268</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231185.1">
        <property type="nucleotide sequence ID" value="XM_016384583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHX3"/>
    <dbReference type="STRING" id="91928.A0A0D2BHX3"/>
    <dbReference type="GeneID" id="27337351"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10268"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_1_1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="527"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW10969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="558" mass="60488" checksum="C45A76BDD264F10B" modified="2015-04-29" version="1">MAAFGGQTPTIIVLKEGTDQSQGKGQVISNINACLAVQATVKSTLGPYGGDLLLVDGNGRQTITNDGATVMKLLDIVHPAARILTDIARSQDAEVGDGTTSVVVLAGEILKEVKELVEQGVSTQTIIKGLRRASVMAINKVKEIAVGTTEGNKRETLRKLAATAMSSKLIHRNADFFTKMVVDAVLSLDQEDLNEKLIGIKKITGGALEDSLFVDGVAFKKTFSYAGFEQQPKSFANPKIVCLNVELELKAEKDNAEVRVDQVSEYQAIVDAEWQIIYNKMEALYKTGAKVVLSRLPIGDLATQYFADRDIFCAGRVAADDLERVCQATGATVQSTCSDILPSHLGTCGKFEERQIGGERYNLFSECPEAKTCTLVLRGGAEQFIAEVERSLHDAIMIVKRAIKNHTIVAGGGATEMEVSGYLHRYADKNVPHKQQAVVKAFAKALEIIPRQLCDNAGFDATDILNRLRVEHRKGNTWAGVDFDHEGVRNNMDAFVWEPALVKVNALSAAVEAACLILSVDETIKNEESQQPQAPARGLPPGAAQRALRGRGRGMPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BIZ6</accession>
    <name>A0A0D2BIZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238741.1">
        <property type="nucleotide sequence ID" value="XM_016377171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BIZ6"/>
    <dbReference type="GeneID" id="27329896"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02813"/>
    <dbReference type="HOGENOM" id="CLU_008599_1_1_1"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="306"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="612"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="780" mass="87396" checksum="E35476704787EBD1" modified="2015-04-29" version="1">MANILARHVSGIGRQLLAIIHSRDRDKYLRGVEKISQTLQDYRGVLQKLFPNMHPDQLREMSRDSLVELISKRSPCHPPSPRTPSVDEKPHLVNPEAGSLEQLQPMPEEGSEVLDQRSTQLRGMTDDVSILSMHVKQNPSYLGISSVMAVLRVITWLNPDCLSDPPDQNALMSRDGGSSPSHQLTESGTTPGDTSSSTAWDEIPLINAYFTYVHPFIPLLEEQSFRDTYMAASRTDTGWLLLLNAVLVMGSIANSSAEDTAHLIYYERAKQYLTIEVLDSAHLETIQALAILSGFYLHYVQSPNQANSLMGSTLKLATTLGLHRDYSEGVGPAKAEKAAYSIEMRRRVWWSTFMLDTWAGNSLGRPSMGRLSPAITAKLPQEPIGQSHTLLSLVRENIRFCEISTRMEDALACSPLLEETERRDLEAMYCEWFKHSSVAPASPRSTTADPPGTTTLKNVMRWRYYTNRIYLHRPALLWYAMRRMKWENLSSEKKAAIELCREACADLINDIATTWRGQKPCQMAGWNANWLMYQAVMVPLLSLYSDTSDATVVSSSQQQVETAMATMRDLQMWSTTAKRSLEVVVRLYESSKHSDGALGPSASSEVLDVCVPSNMTPKSTSDTLPQQQQPHQQQEQQVQAQSQSQSQSESGFRPSYIDVSYANTYGATTAQPLSTAGQEVYMDNMFDTIRWSTSWDSPMGGPQMSHGWDYNSMQHWAGMPHADEYFDVGGGFNEDQSQLGFDLDMQQTQTQAPTSIPSEMMRRGQYGHENMAGGIRHRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ01</accession>
    <name>A0A0D2BJ01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238751.1">
        <property type="nucleotide sequence ID" value="XM_016377181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ01"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ01"/>
    <dbReference type="GeneID" id="27329906"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02823"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="19"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="353" mass="37649" checksum="EDD1C59C536B1F6A" modified="2015-04-29" version="1">MGDCIPKTTPLWRVTGYKGFDSLKFIEEPVPELGDSEVLVKIRAASLNFRDIIIPLGKYPFTQKPNVVPGSDGAGTVLAVGKNVTRFRAGDNVVTMLYQRHWAGSLDAAAEDSALGGSIDGTLRSIGAFDEGGLVRMPQGLTFLEAATLSCAGVTAWNALFGQPGRELMAGQWVLTQGTGAVSAFALQFAKAIGARVIAITSSDAKARFLQKLGADHIINYREVPNWGERAKSVTNENGVDLVVEVVGAATLEQSVASLRLDGTMSVVGFAGGEPEGVEVPNLLSVWLKHYTARGISVGSRLQMEAMGRAVEANIDSLRPIVDSRVFKLAELKEAYMYLQSGANMGKVCIDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJT8</accession>
    <name>A0A0D2BJT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239071.1">
        <property type="nucleotide sequence ID" value="XM_016377501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJT8"/>
    <dbReference type="STRING" id="91928.A0A0D2BJT8"/>
    <dbReference type="GeneID" id="27330227"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03144"/>
    <dbReference type="HOGENOM" id="CLU_326777_0_0_1"/>
    <dbReference type="OrthoDB" id="4508400at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="881" mass="98956" checksum="D953A9B248539168" modified="2015-04-29" version="1">MSSGTSDDSETSWPIDDRPRERTDASKHTKTKRNLNEYLDPQGLASPLAEWHKAAWLYDFYPWSHIADPEGHFDWLEKTHSRVLRSSEFYRIHTKQDVAEWAHRRRRLTNVSRSTLKSILSEDSSLISSDMKRRRHDAYFSFDMDTNTTSSIEALAGSPQLEDILEDLGQSYLILCDILNTLSELTAAKFCEGSYSVLVQHSKPGIAELVLVRRSDLEDVKGSLERGIDEIAGRENSLESIMWRYIVAPICGLLGRLCFPTSTDLFRSWSPSLALCRMTCLLLDLTLITYVGSHATDFQQDLGYFENNIAIKGNLEQISGFRCIRRRLACLDGFLDSNMVWVFERLGPEAPEANVVDSPNLTPLSLLCEMSTFADLWGPVWSVSSGKSRGVQRYAVSKGFIAAVGEKGSSVVENAVPCHWYAMPMSKTELDNVGKQAFNEHDKLLIGTFLETNLNCTYNLDKFQSDYHTAMAPMGTSEASWRPDTRTLGFGFAQYVTANVSATKKLLPGVTYKQSVWDMMQLSPSEANPCFLMNWMGVEVSSCTGHARRVRLIDLFKIKRIQRHLDIRRRDWRTTAWGRSLISWQSDDMNDILDFWHIFQAERKQVAKVIRALLNMLHNTGLMGDVFSACFFTEYDERCITINLELNTWARTLAESTTSGAYVFISEKCLHPRSRGGVTPPPCTNDQGLTALETSIVPIRHRSEVPLEQLDEGGRVEFVPTGQTLTRMNAAKSRRIRLRKTNLPLNTLLRLGRPAAVVQEEVISGVAVVNSEIGVVWMTNLNPGSEEQQEEEEEEEEEVVREGPHESSLEGVVATPSNLRFVVPCGGPGGRALILQLEENIILQSAFDAQISETITSAASSGPNWIPSSSYPEPTHICLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKK6</accession>
    <name>A0A0D2BKK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239321.1">
        <property type="nucleotide sequence ID" value="XM_016377751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKK6"/>
    <dbReference type="STRING" id="91928.A0A0D2BKK6"/>
    <dbReference type="GeneID" id="27330480"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03397"/>
    <dbReference type="HOGENOM" id="CLU_089876_1_1_1"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="80"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="174" mass="19057" checksum="3D3858D3FA738546" modified="2015-04-29" version="1">MSRSAPSRNPSRMVWEREEFYKMNVRERVLALEAQIVADPEFFGFDTYALRDSNSVLVEAEPNKTVWELDIGSHLCNKSGNLHGGAAATLLDNLTSTALVTIAKPGFLDGGHVSRTITMTYLRPVPKGSRVRVECETQAAGRNTANIVGKIYLNGKLCVTCVHDKAVFSTGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKZ6</accession>
    <name>A0A0D2BKZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histidine acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232125.1">
        <property type="nucleotide sequence ID" value="XM_016383502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKZ6"/>
    <dbReference type="STRING" id="91928.A0A0D2BKZ6"/>
    <dbReference type="GeneID" id="27336265"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09182"/>
    <dbReference type="HOGENOM" id="CLU_023111_0_1_1"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF127">
        <property type="entry name" value="HISTIDINE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239095" description="Histidine acid phosphatase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="64304" checksum="21D96310E061A5FC" modified="2015-04-29" version="1">MARFYSVHASTLFFLSLFLAVAPQTVLTQQVLSTFIYTRYGDRTPLVLSSTPSLTPLGAQQLYAAGAKARDRYISPTDGDYTGSSTISGIAGNQLAYDQINVLSTDEQYVSASALAFLQGLYPPLELSSNWTYIEGQSTVANGTNIVAPLNGYQYPQITTISSNDLNSIWVNGMDSCPSYTASGQVYYQSPDYQSILNSTMEFYRSLQPEFLDGIFSNAGVGYYDAFYIYDYLSYAYTHNSTVRESLREEDLTKAKILADDWVFAMNADLSASGTTSGDKIRAIAGRTLATRLLTTFNTAINTQGQTEKMTLLFGSHEPMISFAALTRLISQQNAAFYNVPAPGSSFIFELVSMQADETDEWPNTTDIYVRFLYQNGTDSDSSLVEYSLFGLSPSQGVVPFLDFVAGLEEFLVSNVGEWCTTCGSYSVFCPAFTDTDDKYNPSTGLLSSSHKGLSPAIAGVIGAVVTLAVAALLFAAVMLLGGVRLHRVHTKPKSEMAGFKGGAKMASDQDLVIPKGGAGATMVVAATEAESHPTRGHERVGSWELRDQVKAEEAQGRVLGDAPPRPRRPSYEDDELPITPYTPAVDPHDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLB7</accession>
    <name>A0A0D2BLB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose 5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239964.1">
        <property type="nucleotide sequence ID" value="XM_016374688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLB7"/>
    <dbReference type="STRING" id="91928.A0A0D2BLB7"/>
    <dbReference type="GeneID" id="27327405"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00322"/>
    <dbReference type="HOGENOM" id="CLU_091396_1_0_1"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="163" mass="17442" checksum="DD2ED0EBB63EC237" modified="2015-04-29" version="1">MTTNGTKSPLRIVVGSDNAGHAYKTALKETLKKHSGVTQVLDVGVVNADDATAYPHLAVDACKKIKSGEADRALLICGTGLGVAISANKVEGIRAVTAHDPYSVERSVLSNNAQVLCFGQRVIGLELAKKLVDEWVELRFDEKSASAEKVADISKYEEKFGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN37</accession>
    <name>A0A0D2BN37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232735.1">
        <property type="nucleotide sequence ID" value="XM_016384112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN37"/>
    <dbReference type="STRING" id="91928.A0A0D2BN37"/>
    <dbReference type="GeneID" id="27336879"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09796"/>
    <dbReference type="HOGENOM" id="CLU_450571_0_0_1"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="96"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="606" mass="62296" checksum="9287E746069E04A0" modified="2015-04-29" version="1">MTVLLSTSTVVSTPTQTLTLSQSSDDFSSRTSSVTSQPSTKILSDGSSTTVTPVSTTTSVYPPPLQSSATSIQSSGPIESTTTTSESFSEPTKVASFEYAGCLGPIPDSPFADSFTLRDFSETMSIQQCVSACAGFNYAGIFDTQCFCSLYSGSPPPQDFIKYPDSACNTPCPGDESQHCGGLAHLPPSHRFRLARRQIPEGDDSVVLITTYNNTVGDSVDTSSSSLMSSSTVAGGGSGGSLSSSTRSTLLDVSPTTSTTQVHTSTATMSFSMTTSTTSTITSDVQTQIDSPILASTSSAPVSSLTGGPTSTVITSPTTISTTYTTICVSDSSTCPTPTPTVLTTTIVVLDCGCDGMPSPSVPMTTTFVYCPAAEQTPSKDEDGGETQNEPGESDLSTATLTLNVPCTQSISALAAEVQKWYASAAVTPVVLENHHQPTTTATPAPGRWSDDQGHDDQGQGDNSAYHHQRPYSFPITFPMTPAASAESHPTPETTVTVTLTIAPVPWFNSSTPRNNSTQSGIGNGTGGGTGNGHGTTTQNTPGGAGGGGGGGGVELVPTVSSSVSHSSATRTRVMTLSRRSLQCTALPHFTFVAVTVMAMVVGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNG2</accession>
    <name>A0A0D2BNG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dimethylaniline monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232890.1">
        <property type="nucleotide sequence ID" value="XM_016384267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNG2"/>
    <dbReference type="GeneID" id="27337035"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09952"/>
    <dbReference type="HOGENOM" id="CLU_006909_5_3_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52763" checksum="B36D4B608F6C22F8" modified="2015-04-29" version="1">MPARHPTVAVIGTGPSGIAATKALSDENIFDRVRVFERRDRIGGTWNYDPVPDPFSTGLNGQLKRSLPSHFPHSAPLTAEDTSGRTGLYDTLDSNVGAKVMAFTHTPLPDINSAASIERYGRDNPTRPFRVVAHYLEDVFRDYYHLVSFNTSVERVEKVNGKWVLTLRRSDHILRGERREYWWQETFDAVVVATGHYNIPAVPQVSGLREAYAARPEAFEHSKAYRSPDDYVGKKVIVVGGNVSAADIVADIQGAVSGPLFLAQRGVNEFFKPAFQLPNVVTKPQLKEIKSTTKGIEVEFGDGTKVSGVDKVIFATGYRLSYPFLSPDPVTPNNRLAGFYQHLFKIGDPSLTVIGQLKAGISFRVYEYQAVAVARYFAGREAKPLPPPSEQDLWETKRLETKGPGINFHELRLEWPEYYGFLVDLAGPAAAGSFGYELPPWQDKWAELGFSVIQLKDKYWKRSALEQIRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPL4</accession>
    <name>A0A0D2BPL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241109.1">
        <property type="nucleotide sequence ID" value="XM_016375833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPL4"/>
    <dbReference type="STRING" id="91928.A0A0D2BPL4"/>
    <dbReference type="GeneID" id="27328555"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01472"/>
    <dbReference type="HOGENOM" id="CLU_011715_0_0_1"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="571"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW20893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="803" mass="88438" checksum="C42A454FFF95C1F8" modified="2015-04-29" version="1">MSNTPAKANPSARGPLPAFGAFNPHQGSASLLLEKSNPGLRRSTPDSEALASSDDEVDHVKPSANANVKTNRNVRRTSWLNDVTISNPNRKPSTTGLYSPSTSHPGTPGSEQSPWSSANMTTPGTAWHNPGNNPYGWNIWGQDARKDPPSRLQEVLPTTNGDGFPFSIPLQPTHKAYRSQSYSVGQLDTTSALPATAPVSTSIEATRNRLGSAYPQRHITRTNGVGGLDSVGLGRLREVDDDEEEGHVNGGIPDQLATEQARVIERLEKENAQLRQAAHRERTFSAASTATQPPPGFRTRLRGAVPEEEETAIDDRDEPIYPPRPNATRRMSEQALSFADRQAFAAAETRNLDGVKKAHWQTSLGFGPIPEAPQSRRHSFADVPTRHGSFSSSERGRDASMYEASTQALSQGEDPAYFNTDEATRRAADARVQQSHQNYGHLNVGQYLEPPVQPLYIVNFKCCRSDVFYIQEGTGLHVSVGDLVIVEADRGTDLGTVQHTNVSWEDARRYKEYYAEEHYKWLMMFSLQSRNGGPNVVNPNGLAGRPGSAVGGMGLQNHHGHDGTHQELKPKLIKRLAQNHEIQALRDKEGNEAKAKRVCQQKVIEHRLNMEILDAEFQMDSKKLTFYYFADSYINFNALVTDLFKIYKTRIWMSAINPASFQTPTASLGLTPAYNPAPGDERHRRRQQPASTHELGPQPVTTPFGDTFDADRNFNNQSQAIRNAYYPGYQDSGAAHQQVPPGMGSYPANMGGQMDPFMSFYGPGYPGLNPNATSFATGRSDFRARGPAQQDWMGRFQGLSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPS9</accession>
    <name>A0A0D2BPS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240716.1">
        <property type="nucleotide sequence ID" value="XM_016375440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPS9"/>
    <dbReference type="STRING" id="91928.A0A0D2BPS9"/>
    <dbReference type="GeneID" id="27328158"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01075"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22670">
        <property type="entry name" value="FHA_MEK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="113"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="53870" checksum="C3C3D9E8DA8AB72B" modified="2015-04-29" version="1">MIIGRDNSRCQYIIEDPYISKRHVRLYTVVYEDDDLGGVETLVYVEDLSQNGTYWNGSTIGRGNGGYLLSDGDVLRLSRRTILTFHTVPNSSSNVNFDLTQEREMTLFRGEYVITDRLLGSGTFGRVFMAIEQHARAQVACKVVDLRKMTGGALRHGSPERPVPAEAVDIRVQRRQIKAWADQQKRENCLEGKLKLYFREIEILTSISHPNIIGVEKVYVTQNTIYMMQTLVTAGDLFSYIESKNGSLLEVEAAVIIRQILIALAFLHENNIVHRDIKPENILMTSLATGSRVVLTDFGAARRIANPRSRMQTALGTREYAAPEQSHNGKNGRAGYTRAVDMWSVGCVTVVLLTGGMAFSDPITNSYSESLAADCNLKSLQETPEWEKIRERPKDFISQLLVLDEAARPSAEEALKHSWFSNELHRTDFEELYQRTIKHWNPRVPKSPSIDFKGGGNCYKYMSSSSDPRDFSKRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQB4</accession>
    <name>A0A0D2BQB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08512</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233540.1">
        <property type="nucleotide sequence ID" value="XM_016382837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQB4"/>
    <dbReference type="GeneID" id="27335595"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08512"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="472" mass="51359" checksum="E7589CADD3A4AFF4" modified="2015-04-29" version="1">MMSGLNILPSYTDYFHLNTATFALQSAIGWAGTATAGLFYGQVTDWIGRKKAMWLSAVITLVGVILQVSAQNIAMFVIARFVVGLGNGTAFLCGPVYLSETLTLKWRGVGLGIFMSFFYVGGLLAAGITYGTAKLDSTWAWRLPSALQGVLTLISVTVLPFVPESPRWLVYRGRQAEAMSVLAATYADGNREDPVVMVTYKEICDVLEREVTEGQRLNPYMLLKNHQNLRRLALCLSVAAITMLSGNNIISYYLGKMLDNAGITNTNTQLEINIILNAWCLVCALVGTFTLDVVGRKPLAIVSSVAMTVFIFLVGALTKRNSNSSGVYGTVALIFLFQGSYSLAWTPLAMLYPPEVLNYSLRSSGIGVYTFASNGLGLMVTMSFPYALDAIGWKTYMINGCWDVLQVVYVVIFWVETKGKTLEEVDELFGVEPSSGVPHLATVIQGVEPGLRLRGSTDLPIAAPLTETMGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQF2</accession>
    <name>A0A0D2BQF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">IZH family channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240931.1">
        <property type="nucleotide sequence ID" value="XM_016375655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQF2"/>
    <dbReference type="STRING" id="91928.A0A0D2BQF2"/>
    <dbReference type="GeneID" id="27328375"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01292"/>
    <dbReference type="HOGENOM" id="CLU_029962_0_0_1"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="56171" checksum="D3B3E6823ADEADD9" modified="2015-04-29" version="1">MTCTASAVTIESSSSSPATSSSRDDERTALFLRGRRHSYNTSRRRNSSICNADAVFVRVDLFLTELRQRVDRLEKYRQESILSLDSQLERAFQIVRDVRDSCSPYHSGELLWGAARQRANILVETLESRYNDLMPSRETFEQKAQASLRLMECYLSELETRAHSRKKQLFDSGWKKVDDSITATREILEDGFDKAIRATDLLAESISHALSRAAESRLIHYDDLPVPWRNNPHILRGYRFNRTKIECITSAFRPSNETVNIWSHGIGLIIVLAVAFYYYPASSTFPLSSKWDVLIAASFFLAACKCLICSIMWHTMNSIADKCLLDRFACVDYTGISFLVAASILSTEWTAFYCEPLSRAVYMTMTALLGIAGVILPWRESFNRADMAWARVSFFVTMAVTGFAPVIQLNYTRGVAWTFYFYAPVTKSVMVYLTGAIIYASKVPEKWWPGLFDYAGGSHNIWHIAVLAGILFHYTAMQEFFHGAFQRANDGCCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR58</accession>
    <name>A0A0D2BR58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Threonyl/alanyl tRNA synthetase SAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233935.1">
        <property type="nucleotide sequence ID" value="XM_016383232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR58"/>
    <dbReference type="STRING" id="91928.A0A0D2BR58"/>
    <dbReference type="GeneID" id="27335993"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08910"/>
    <dbReference type="HOGENOM" id="CLU_004485_3_0_1"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000018">
        <property type="entry name" value="Alanyl-tRNA synthetase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000008">
        <property type="entry name" value="Similar to alanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF2">
        <property type="entry name" value="THREONYL AND ALANYL TRNA SYNTHETASE SECOND ADDITIONAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Threonyl/alanyl tRNA synthetase SAD" evidence="3">
        <location>
            <begin position="229"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="273" mass="29394" checksum="9820DCD4E1BA7DA4" modified="2015-04-29" version="1">MAASIRRTVLSYQLNAKLYTLPTSVVAITPFPSLAESNRQLFKSATDDDSVVVTEETIFHPQGGGQPSDTGSMTSSSGSSFLVSAVRMSATDEGQVLHLGRFADPSKPFASGETATQHLDVDKRLLYSRLHTAGHVLGAAVRHLLEKQVPGFDELKASHFPDSAACEFAGLIEGKWKDGIQAKLDEYVAAAMPVEVDFWTEEDFRTNGLERLIPNGDGVKLAPGEKYCVVKIIGAEVYPCGGTHVDTTDQCGKVGVRKISRSKGTSRVSYNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR61</accession>
    <name>A0A0D2BR61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chaperone DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_01504</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241141.1">
        <property type="nucleotide sequence ID" value="XM_016375865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR61"/>
    <dbReference type="STRING" id="91928.A0A0D2BR61"/>
    <dbReference type="GeneID" id="27328587"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01504"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_2_1"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254704" description="Chaperone DnaJ" evidence="7">
        <location>
            <begin position="23"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="149"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW20925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="47356" checksum="92AFE790EE6998A4" modified="2015-04-29" version="1">MLLLQVLRHLLPLLLLFTCALAVEDLYKILGLDKSCSERDLKKAYRTLSKKYHPDKASGDEKKFLEVADAYETLSDPTTRKIYDQYGHEGLENHKRGGGAGGHHHDPFDLFSRFFGGGGHFSGGSGNGIRRGPDLEVRLHIPLRDFYTGRDTEFTIEKQQICEECEGSGSADGQVETCHQCGGRGIIIQKHMLAPGIFQQVQAACDQCGGRGKSIKHKCKVCGGNRVVRGPTTLTATLERGMPKGHRLVFESEADEHPDHVAGNLYAYLMEQEPAMPEDESQRTDGTFFRRKDDDLYWKEVLSLREAWMGGWTRNLTHLDGHVVQLSRNQGEVVQPGQIDTIRGEGMPIFHEDHMHGHDHDGEEFGNLYVEYKVIIPDQMDSGMHKEFSAVWDKWRKKKGVDLLQDSGRPTYIVRGKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BTB5</accession>
    <name>A0A0D2BTB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241866.1">
        <property type="nucleotide sequence ID" value="XM_016376590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BTB5"/>
    <dbReference type="STRING" id="91928.A0A0D2BTB5"/>
    <dbReference type="GeneID" id="27329313"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02230"/>
    <dbReference type="HOGENOM" id="CLU_022730_0_1_1"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="344" mass="37698" checksum="589760A8EB4AC0DF" modified="2015-04-29" version="1">MFIPLPNGTTSFWRTEPDELDNHRSSKSLPDSCDIVVIGAGYAGVSVVHHILGRGNGKATPSILILEARQACSGATGRNGGHMKPDPYNSISRLAGEHGIEAASEVAEFEARHVTAIKDLIDHEGIKCDYVLTKAMDVQLSADHCKAMKAQYDRLTDGGCRPTQETEYVEKKDAVIGAQGCFVYAAGHMWPYKFVLHLLRRALDSGHVNLQTHTPVTSVVRSMKNHGSHPWIVTTPRGSAAARKIVYATNGYTPSLLPQFADVIVPVRGTCSRIVVPKHSTAPRLNNTYTICWNSWDYDYLVPRGDGSIIVGGARSSFVHQIGDWYNIIDDGHVLESAAKYFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BTG7</accession>
    <name>A0A0D2BTG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234725.1">
        <property type="nucleotide sequence ID" value="XM_016381623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BTG7"/>
    <dbReference type="GeneID" id="27334376"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07293"/>
    <dbReference type="HOGENOM" id="CLU_088985_0_0_1"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="284" mass="31825" checksum="FA440F7E4DD977A3" modified="2015-04-29" version="1">MHSKNAPVGVYTLYYNRFSICSLMTLLTIRWKGQPASLEQAIDIVEEEVDIYAGEQNEEEFLKKNWKGQVPVLLGPCDLKVTDSLQITKFLASRYTGLIPSGCEDVITAMLNELHQVWFVSLSFSAQEGRGAGILLQIQNILAQPTTSDDYKTALQRKLQYYATTYQADPHAPEIVAREKLKTQKFLEKIARTRHFHNIERKSKWIFGVEIGPTALDAHTVVFIARLIDAGHASLIGSDMLEYGTQHLESNAWRGIVDGNTTLHSLWERQEAAKTMTVGGGAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVA8</accession>
    <name>A0A0D2BVA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_05244</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235415.1">
        <property type="nucleotide sequence ID" value="XM_016379588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVA8"/>
    <dbReference type="STRING" id="91928.A0A0D2BVA8"/>
    <dbReference type="GeneID" id="27332327"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05244"/>
    <dbReference type="HOGENOM" id="CLU_013394_0_0_1"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF301">
        <property type="entry name" value="POTASSIUM CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="219"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="388"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="537"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="701"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="538"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW15199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="775" mass="87089" checksum="77F2C2B31591E92C" modified="2015-04-29" version="1">MNDPGLAEPIDNADSQVKENVLSPKKKSPEDDMDEEEEERNFLTPARWWYASTGFPLIAGTFGPMANAFSICALVENWRVKIPPGGTEEHGIDIKDPRWLIAVNAISLVCALIANVSLLLNMARRVPFEVAQPITIIGFWTASILLIALIAVASHHFHAPGVRDQALTQAYYYAIFAAGLYQIISYLMCVTVYGAYKGYYSREFKLTVAQRTLMLQTILFLTYLLLGALVFSHIEAWKFLDAVYWADFTTLTIGIGADYTPKTHLGRGLLFPFAIGGIIILGLVVSSIRSLVLERGKKKLAARLTEKTRARLVREIEKSMQKQIDLKRQIAMGLGKATADALTVKPGDDRMAEKDRRRAEFEAMRKVQDRAVTQRKYMSLGISSFAFAFLWCIGALVFFRSEHNQQWTYFESLYFSYTTLLTIGYGDFQPISNSGKPFFVFWSLLAVPTLTILISDMGDTVVKVIKDSTIWLGEVTVLPSDETSMKNRLKYGIYRSTWGKLGSPHSDVESVEGEQNGFHELHPGLVKLFRIGSGGRQQDTRARADHAELAGDVEQSKRVDESQARKGGSHWEENEHNNRHVLLSQIRKVYTDTTASTPKRYSYDEWVDFLKLLGEDERDPTTHRHASALADPTFRQGDTTVDNRKVLDLGGQEGAYGKGSDKKKKVKWSWIGNRSPLMGDKEEAEWLLERLFEKLEESLRRELDEREEEQEGAKKKPKRRINSIADQEDTCTSGSEESSDTTRCRESGQTEQGGGAGGGGGGAEEEERKDPVRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BWK4</accession>
    <name>A0A0D2BWK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Checkpoint protein RAD24-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235880.1">
        <property type="nucleotide sequence ID" value="XM_016380053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BWK4"/>
    <dbReference type="STRING" id="91928.A0A0D2BWK4"/>
    <dbReference type="GeneID" id="27332796"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05713"/>
    <dbReference type="HOGENOM" id="CLU_006397_0_0_1"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="511"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="802"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="832"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW15664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="912" mass="98665" checksum="42F17CA75A79093B" modified="2015-04-29" version="1">MALRPAKRQRRSTIVLSDDSDQGEQPRAKTQKSSHQREITLDGRTSQNVSPVKTPKGKAVAKKGPAQKSPSHSSPEKQRKTTRIKAEPEKSGSLHNFFSKATAEERWRKKSVTPDIDAENGELLDAIEDDDLSDDTLQELGLKTNTGGPAADRRKPAISATSGPSNRSIGTSFPASQRFVRPSDMNRPSSNDVNQTQPEEGHRPWADRYGPNSLEELVVHKKKVSDVQNWLQGKIDGRNGQKILVLKGPAGSGKTTTLSLLAKSMGLQLVPWHNPTASETGSKNSVAAQFDEFLNRGGRFGSLVFGDDSTQSDVSKQDSAHRVLVIEEFPATMARLSGALQSFRSVILQYLARSRAASTATLRGQPSPDHGSPPVVIIISETLLSSSTALTDSFTAHRLLGPEILNNPYVTVMEFNPVAPTFVTKALDIVMKKEARDSRRRRVPGPAVIQKLAEMGDVRSAVNSLEFLCLRGDNNSEWSGTVAAKAKKSSKDNVPLTDMERDSLQLVSQRETTLDMFHAAGKIVYNKREDPRVLDTRAEPPPKPPDHLMHLYTPKASQVDIEALLSETGTDIQTFISTLHENYILSCSGDKFEECFDGCSDMLSVSDVLNPESRPSQRASWNPYASIIQANLQAGSSDTLRQDEISFQVATRGLLFSLPYPVNRASLPGGKKGDTFKMFYPASLRLWKPTEEMDSLIEMYVNGDGLGTGSGGALSHKASSTVGDGGVATWRTRAFGGADTYSGIESGSGADDDDDERERRQIRYAKDTLTLEVLPYMTRIFATTSKDTGVLERITTFRPNVFLSPAVGDQGPEDDDENDDVVAGAGAGAGGDATVNTTGSGSVSTAASRLSGSASRRTGAVPSPLMPHTFRKNETTSSNGARPRPGTGDGVDGIDLGAVEKLYISDDDIEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C0B5</accession>
    <name>A0A0D2C0B5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237230.1">
        <property type="nucleotide sequence ID" value="XM_016378553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C0B5"/>
    <dbReference type="GeneID" id="27331288"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04205"/>
    <dbReference type="HOGENOM" id="CLU_012970_2_2_1"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF200">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="64234" checksum="329F9599D4E4B902" modified="2015-04-29" version="1">MDAVTQAHDEPSSAQQVSKSDQHTQLDQDDLEMAKSTMIVADSTVTSGTARAEAMQLVWGTNGRCIVWLGICVMLIVYQFDHALLYNYRNYATSDFDNVAGLSTLAVAGNIVFAVAKPPIAKISNVVGRAEAYLFCIVCYLLGYILCASSSSFGVYAGGFIFANLGMTGANILNDIIIADVTSMRSRAFAIGISFFPFLITPWISGFIVQDVVGPGGIGWRWGIGMFAIIMPFSAAALVVPLLYYQRKAKKLSVVLTQKISIVDFCSQIDLGGTFLLTAGFAMFLIPFSLAGLTPSRWDTGYIIALIVIGAVTLAGLFVYEIYAAAHPILPARYFRNISIVICCSLGFLDTLGFEATHTYLYAWATIVHNMGPRDATFLNYTNGVWQCLVGIIAGAIMYKTRRYKWLMVIGTAIKLLGFGLMIRLRGADNSWAELFVVQSVQGWGSGIIEIAIIVGAQVVVPHAEMAQVTALVLLCAFVGAAIGDSIAGGIYSGSFKDALRHHLGSGATDTIVDAVFESITSTDIPAQGTPQRKAVNLAYSDVMRNITYVAVGTSVLCLVVAFFLPDLLLKEGQSLVPGGNADASIERGETETETGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C119</accession>
    <name>A0A0D2C119_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_04573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237595.1">
        <property type="nucleotide sequence ID" value="XM_016378918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C119"/>
    <dbReference type="STRING" id="91928.A0A0D2C119"/>
    <dbReference type="GeneID" id="27331656"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04573"/>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW17379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="455" mass="50134" checksum="B915008FFC9DB75C" modified="2015-04-29" version="1">MEPANDSPTSQHSDILIVGSGVFGTSTAYHLSQSHASLRVTVLDRAPAPSPWAASSDINKIVRADYSVPFYMDLAYEAMQYWTDSPLMSRFFHQTGWVALDEKDSDLSTRIRKNFRESGRADASADITLDEVKTRWDGVLAGIDTTGYDKAYTNSSAGWADASSAVEAMMAGAVQAGVHYEVGEAVELVADVDRRRLSGVRTADGRFFTGDRILLATGAWTPWLMSPLEKALHIPEEDSIHRQIQAAGVCVAAFQLSEAEAEHYSCMPVLIYGSKGEVMPPTAATTTTTANDDDKAQGERFFFFKFTNSNTFLNTTLHPDTGQLISVPAPDQRAVPSALRSESIDVIRRRVPAILHNGRVPDDWRICWDAVSPDQNQLITRHPVSTLSNLFLATAGSFHSWKFLPNIGRYVVNVLDGKSNGPIKDEAWAWKRTWAGRGAHEKVLPKREFADISKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3A9</accession>
    <name>A0A0D2C3A9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238305.1">
        <property type="nucleotide sequence ID" value="XM_016376735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3A9"/>
    <dbReference type="STRING" id="91928.A0A0D2C3A9"/>
    <dbReference type="GeneID" id="27329459"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02376"/>
    <dbReference type="HOGENOM" id="CLU_419785_0_0_1"/>
    <dbReference type="OrthoDB" id="4160691at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="667" mass="75613" checksum="15C6CCD648DE09F4" modified="2015-04-29" version="1">MFSTGRRNYWVERGPDGRLREARDLPEEPLPRERAGEKRSGADEVVIEVPDASPIVETQEVRLLRRNLPSFGEVERLLDLYVATGEGRGAYTKAVKTVEQEHRRRFVEHYYGDDDDRFDDFINYGGPGPGGGGPPRSMPIFARGSYDYDLDEYSERGERSRHPTESIYVTRAPRERRRTQEGSDDSDDDDDRPTAGQPPLPRPSGGGPSSGPRGSYVINLENPRNARPGALDLEETTRVTSRPPQEGARRENVFVRTISPRRVVIHQDNREIVDEEHIRPPVRIAERYRSTRRRMQPTVQEVSDEDGEVSLRSIPSEEDDLRLSTTRELEVVRGPRPRSRRVQSIFQSSPGVRLSQRRSMRGGGLPEHIVEEMWGQNFRRRLHLRGGGPVVAPPTKTAAVGGGVVDDFSTASKTIALYFFSVSKGRIISSRKRELYRTFRELYPHEYSSDVAHSSDVWLVNRLKEHYWTICRRGQRSIWDLTSMRTIGFAIFIRFERTVKRGHDPGNYFVTARAPAISAEGQEAVSHFVYMMRYPLQKSKMMLFLLDRMAGSTKRGNDHNTFYAVEIKETFDTSKIYFLLAILILVSTAAGVVYSVVKSDPGTGLSIASYILACLSLILAVVVAGEWLGLRKPDAFSFAYDWVENRVVGKDDLDRIAGGRLSTYQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3B2</accession>
    <name>A0A0D2C3B2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238310.1">
        <property type="nucleotide sequence ID" value="XM_016376740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3B2"/>
    <dbReference type="STRING" id="91928.A0A0D2C3B2"/>
    <dbReference type="GeneID" id="27329464"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02381"/>
    <dbReference type="HOGENOM" id="CLU_020821_0_0_1"/>
    <dbReference type="OrthoDB" id="5357734at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37576">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37576:SF2">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="631" mass="68631" checksum="5951AB14E414FE1B" modified="2015-04-29" version="1">MSVPMKTLASSQTSLVSVRREGVALDANEEVRQDEPKGFACSEHKHVRHDFFPPTQYPHEKIAIDKASFPIKGFAGLIGAALAVICSWALLVASNNTQQWQERFPTVAKVLQPSSILSAIISANGILLHLAFTEGMTIAWWLRATKTGATPSELHEAWVTSTSALGAVQSGRRFNYMALATIVVAIIPINGLVLQGALSVRPVFLNTASVNVSVPFVNDFDPSFSGSLTATGALDVISTTFSGEVYNYFAGDNKGYIVLYSNGTTDENVDYDADASPTNCKETCIFDAPGVGLYLSCDEIEDHPFNFTVDTSQPGWEELPIVKQGLPIYSTAFGWSASNPNTIQFNLTSKDTYGCSGQYYQLACSLDARHTTYNTTLHLNNSGLSGATTLSLDPDSDYSDDLYGTPIAANDELSSRKTKFGFLAKAFNDYFGSSIVVQYSNASGEPEYVLGQNGTYANAPWIIYGQDGRETSGDTVNLTAHGAQGCEVWIDWERDPLSNDRDVIMAEIRRFMFRLSYEYSNSASLTTYPPLLARAFVTQNLYQVSWWHWVASLAVTLVIVACVSLTFWGFWALTRLPTMSPLETAQAFQAAAGSSPDLAWDQATMSPPPGTHLAADGRSMLSSSGMSRPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3P7</accession>
    <name>A0A0D2C3P7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238485.1">
        <property type="nucleotide sequence ID" value="XM_016376915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3P7"/>
    <dbReference type="STRING" id="91928.A0A0D2C3P7"/>
    <dbReference type="GeneID" id="27329640"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02557"/>
    <dbReference type="HOGENOM" id="CLU_154205_0_0_1"/>
    <dbReference type="OrthoDB" id="194076at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="107" mass="12834" checksum="635F50C8F84CA92C" modified="2015-04-29" version="1">MVYTITVHLRAKSSDPAIIQKLKNKLIEASRVYSKDKETISWFVMQSVHDPRDFTIVERYEQESSQKYHLENPYWKTFDPYVKPLLEGEMDLRRFEELDTSKDVFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C5X8</accession>
    <name>A0A0D2C5X8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_03238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239165.1">
        <property type="nucleotide sequence ID" value="XM_016377595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C5X8"/>
    <dbReference type="STRING" id="91928.A0A0D2C5X8"/>
    <dbReference type="GeneID" id="27330321"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03238"/>
    <dbReference type="HOGENOM" id="CLU_075333_0_0_1"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052174">
        <property type="entry name" value="Flavoredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43567:SF1">
        <property type="entry name" value="FLAVOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43567">
        <property type="entry name" value="FLAVOREDOXIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="4">
        <location>
            <begin position="10"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="261" mass="28422" checksum="C0DFF2EA1E716C14" modified="2015-04-29" version="1">MEHQEISPAILYWGTPVVLISSANDDGSANIAPMSSAFWLGHGAMIGLDASSRTTQNIARTRQCVLNLASDDMAAAVNALARTTGTDPVPAGKRTRGYRFVKDKFAVARLTPQPSRHVACPGIKECPVTMEAELVATHTMFGDGSAAAAEEALILAFEVRILRVTVHENLRMQGEGLCNRVDADRWKPMIMMFCELYGLKQGKLAHSNLADIDEEAYRPFADLSRKGKIEAVDVYVDVDADVKVVQEANSERAHELGADNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6E4</accession>
    <name>A0A0D2C6E4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239355.1">
        <property type="nucleotide sequence ID" value="XM_016377785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6E4"/>
    <dbReference type="STRING" id="91928.A0A0D2C6E4"/>
    <dbReference type="GeneID" id="27330514"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03431"/>
    <dbReference type="HOGENOM" id="CLU_046006_7_0_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF6">
        <property type="entry name" value="BLR8189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="166" mass="18204" checksum="F4841A717B0998D4" modified="2015-04-29" version="1">MSEAKTWNRPLNHVAVSVPDVQAVVDWYSTHLGFRLLGKIAHIKRSTDPDAAIFGIYPSNLNEVKLAYMSTGNGVGFEVFEFVDPKPVAAEREFQYERAGFFHVCVTDPDPDALADRVVGAGGKKVGQTVDPGNVGVKCLYLADPWGNIVEVLSVSFEWLACRTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C7X9</accession>
    <name>A0A0D2C7X9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239905.1">
        <property type="nucleotide sequence ID" value="XM_016374629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C7X9"/>
    <dbReference type="STRING" id="91928.A0A0D2C7X9"/>
    <dbReference type="GeneID" id="27327346"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00263"/>
    <dbReference type="HOGENOM" id="CLU_035733_0_0_1"/>
    <dbReference type="OrthoDB" id="5419542at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="348"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="512" mass="57270" checksum="42CCCB0875643586" modified="2015-04-29" version="1">MSQQLGMPPPYSRSRSHTDPSKSSPSPTEPQTAGANLQPTRPSHVRSRSYLSPTETKPRNALTLPAASALERTAERLHRVHIPGSSHLHHHRSSQHQHSRSHSHARGSNASDVPYKGDHRPTQSDGLTHKTSFRRAQSKQSKDALPHLLAGLNAERDKRNHLQRINTNTNAHTHSNGSSTTTTGQSGSSLHPPLASQTSEHADRRNLDARLRETSEPYNRPQPRQKTSFEEALDRGDQARVARRIYVKKADIQRHDAEIAAAEDEMRTRIANMTAKGVEITRRLDYGYYNLLETINSLVATITSFQSLSDQTSQLIINFDKESERLDQDTSGRVERFKREFEVRNAKAEQLSARGKKVNERAEDLSLRLENARVVLKNWERKEDEMRKVWFRVGRVGWYLSLLVVISVLAFVVGKESLSRRGGVHGESTGDTRGAWNGSIDLPTVDVTLLSETPGVPDDVKRLIEGAAERNKARNHGSAPGAEDDGGTTMKIGKDAKVVNVDDPRFRVWDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y579</accession>
    <name>A0A0D1Y579_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_11847</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW10071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230287.1">
        <property type="nucleotide sequence ID" value="XM_016386155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y579"/>
    <dbReference type="STRING" id="91928.A0A0D1Y579"/>
    <dbReference type="GeneID" id="27338930"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11847"/>
    <dbReference type="HOGENOM" id="CLU_482345_0_0_1"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW10071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="565" mass="64015" checksum="781D559A117A732A" modified="2015-04-29" version="1">MEASNGSDGSDMSLSSQPYPTVYTDHSLLNSSRRDSRYPKPVTSTYILGSWKLNKILEYPDHGKFFITYFHYSVIIHCQYQNCEYGSLEAGLRMLPLDAKSEALYDALQYHLQNIEFGAITFLTLKTIGGTLEVQVKSLHERSDINGNILEESPSVSSRGGDLYQRHNEESRREGFHEIDLRTIDPGTLSCPSLASETPTTLRREIAEKYPRSKAKPTMVDDNFGAIRQKIESAPKAFASRSEIARHKLIHSGIKPHACDFEGCGKRFTRRPNLTRHMRVHTGEKPYMCERCSKNQQAQLILSHSIQVNFMDIESLLLDPNQSEGSPGQDSTTIDIDSTATGNYHEVVQVSEESIDSQATDQRFSYEQLLLILSCLYVTTGDHYRTGDERPLDDIIQRHPETWTRTLDKESWKSVHHAFNSISSTMVASKELKLWRNIILDKLQRLPDQSIPPIIPEQLDWDWERSAHLVCLHYGVSSADPDMSKFWDEERFTRLTEKLSGSAMFPNSLTLGELKSAVNSLALLLGKPAELNPSLFPLMIPRDRTKRSAEGGLGGRNAKIPRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YA11</accession>
    <name>A0A0D1YA11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232012.1">
        <property type="nucleotide sequence ID" value="XM_016383389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YA11"/>
    <dbReference type="STRING" id="91928.A0A0D1YA11"/>
    <dbReference type="GeneID" id="27336151"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09068"/>
    <dbReference type="HOGENOM" id="CLU_038526_0_0_1"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000725">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="350" mass="38529" checksum="52011923F71DC354" modified="2015-04-29" version="1">MSNQFAVPEPPADAISALRFSPQPDSFRFAVASWDKNVYIYELSDGKSCKQTAKFEHRAPVLDVCFGKDDNEIYTACLDWDVRRIDLKSGTQTVLSTHDNSVRSVVYSKEHSLVISAAWDSTLHVHPGDGDASWSTATINLPSKPFSLAVSASKLVVAMANRALHIYELKALADECKSSSANSLQNRLDIEPWQRRESSLKFMTRAVDCMPNDEGYASSSIEGRVAVEWFDPSNESQARKYAFKCHRQPVDDVDVVYPVNAIAFHPVHGTFATGGGDGVVAIWDAIAKRRIRIYPKLASSVAALSFSSNGKYLATAISPGFEDGKDEIAEGSIGIYIRELGENEVKRKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YAA6</accession>
    <name>A0A0D1YAA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase synthesis protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_09154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion inner membrane</location>
            <topology evidence="2 8">Peripheral membrane protein</topology>
            <orientation evidence="2 8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the ATP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232097.1">
        <property type="nucleotide sequence ID" value="XM_016383474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YAA6"/>
    <dbReference type="STRING" id="91928.A0A0D1YAA6"/>
    <dbReference type="GeneID" id="27336237"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09154"/>
    <dbReference type="HOGENOM" id="CLU_050107_0_0_1"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000044">
        <property type="entry name" value="ATPase synthesis protein 25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040152">
        <property type="entry name" value="Atp25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="323"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="389" mass="43291" checksum="6F0EB00715AE9AA8" modified="2015-04-29" version="1">MHRTPALSRCTSCRRSILEAFTSLAGVNLPARTALPPLSRPLQTQTRAFSHASPFRQSLEPPTSSDQSEFVPWYLQVEDPEPPVPASPLLALQEIPPLPENPPAILSSVLNHLSTQIGLDNLTLLDLRHIDPPPALGANLIMVIGTARSVKHLNVSADRFCRWARKEYKLRPFADGLLGRNELKLKLRRKARRMKLAQSVGNTMVTRESDDGITTGWICVNMGPVDEAVLPAEVEGEAQTALAEASVADSRPLPDEVAEDEEDEYTNPPDDYVGFGSRINSPRIVVQMFTEQKRLEMDLEGLWDVRNTRRARKASRANAAVEETQREQDMEAASARDKEVHEEATKQNSPRDDPMHDEDVPSKMEKEIERTEEREGVDQSKPMGSIGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YB64</accession>
    <name>A0A0D1YB64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_09441</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232382.1">
        <property type="nucleotide sequence ID" value="XM_016383759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YB64"/>
    <dbReference type="STRING" id="91928.A0A0D1YB64"/>
    <dbReference type="GeneID" id="27336524"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09441"/>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000009">
        <property type="entry name" value="Guanine nucleotide-binding protein G(O) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="180"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="205"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW12166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="358" mass="41430" checksum="E86479C498ABE929" modified="2015-04-29" version="1">MGCTGSKIDPQEKEASQRNARIERQLRHDRKAESRTVKILLLGAGESGKSTIIKQMRIIHSNGFQEDERVQVRAVIYSNVVVAFRVLYEIMQDEKIEFEDEANEAHAEFLESIDSDVDAHEAFRDKRVKEAMVTLWKDAGVQKAVAKGHEFALHDNLNFYFQNIDRMFEPGWTPNDQDMLHARLRTTGITETVFELRELTFRMMDVGGQRSERKKWIHCFDGVQCLLFMAALSGYDQCLVEDVNANQMHEALMLFESLVNGEWFKDKPIILFLNKIDLFREKLPVSPLSAHFPDYTGKEGDEEASKQFFANRFKSINKNSDREIYIHFTNATDTNLLKATMEDVQDILIQKNLQRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCI2</accession>
    <name>A0A0D1YCI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232847.1">
        <property type="nucleotide sequence ID" value="XM_016384224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCI2"/>
    <dbReference type="GeneID" id="27336992"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09909"/>
    <dbReference type="HOGENOM" id="CLU_081019_0_0_1"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2470" evidence="1">
        <location>
            <begin position="34"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="250" mass="27087" checksum="81E04E1F4B1FBAFA" modified="2015-04-29" version="1">MSTEPLLATAAATSAGTAPAAAPPRGAPDAAAMKSRIITHMNADHALSLRLYLMRYAHVPLGGTTGAQMLDIALDHMVLQSGYGRHVVALAPPMKSLLEARERLVAMHASCLADLGLSDVVVDRYVPPARASQVAVTALSLLVFATFPFRDALLDPTTVPGGVWSLAGAAPWLARLGYTLQPYVLSFMVVAHLAETAFLTVPRLKRHWVDVGSWLWWAWVLDCAVEGFGCWTRLDEIVADVEEKRKTRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YDS2</accession>
    <name>A0A0D1YDS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_08388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233417.1">
        <property type="nucleotide sequence ID" value="XM_016382714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YDS2"/>
    <dbReference type="STRING" id="91928.A0A0D1YDS2"/>
    <dbReference type="GeneID" id="27335471"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08388"/>
    <dbReference type="HOGENOM" id="CLU_048953_10_0_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF48">
        <property type="entry name" value="ECTOINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32013" checksum="13593DB7621ACE6D" modified="2015-04-29" version="1">MTSFVPTQALVEQYHRDGYLLLRAEEHGLVDPKELQLWTKEVKEWPAAKGKWMPYHEVNVSGERQLMRTENFVDYHPEFKELLCGDAIAQILKTISGEDMLLFKDKINYKLPFGNGFAAHLDAPAYDHIGRIEHLTANFSVDEATPENGCIEVVPGSHKMDVELSHGGAISQAWQDGHEWTKVPLHPGDVLLFGSHLAHRSGPNRTNTSRSMIYATYHGKSDGENLRQQYYKHRRENFPPDSERVEGKDYSQGYKTYGFAAPFMSEKQVEQEKTRVQTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YEE4</accession>
    <name>A0A0D1YEE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High-temperature-induced dauer-formation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233662.1">
        <property type="nucleotide sequence ID" value="XM_016382959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YEE4"/>
    <dbReference type="STRING" id="91928.A0A0D1YEE4"/>
    <dbReference type="GeneID" id="27335717"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08634"/>
    <dbReference type="HOGENOM" id="CLU_007392_0_0_1"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="943" mass="104327" checksum="7A6B763B0C5FB9A4" modified="2015-04-29" version="1">MGASESKLVFKQGIFKLSEERNIPASDPYWTGFWELPESVEDVFSLFSHSDIRRARDSALENLETLILAVTSRLIVLKNHPSFPDPDLAPERDALNCIRVLTRLLPYVYEAEQLAEWEEKFFWGLRRRRTRRAQVAGEILFDDSQRLETERVDGEDQDFEEAKPLAEELIDTLIDLLFYAGFTIPYLPQAKSKVTYAIWQSGVGCKASIPTNKELETNRCEVLRLLLTLTSKAMYMPSGTLPVQGVKAITYIATCPDKQIVLSVLCSLINTTIKSSTSSWRLPYDHVVRRDSKQTLVIYSLQFLLVLLLYPVPEGGNQATPKNFYRHYLGRLHRPEDFQFLADGMTRVLSQPMEATTSYLPGSQKSVKWAPEMIMLFWEALQCNKRFRAFIIESNRAHDFIILMLFYAIEYKTDASRQGIVRMCVFVLQTMSVESPFGNNLNKKFEGQDSLPPSIRLSNFRGTYADFLIISIHTLITTSKGKLEAIYPALLAIINNMAAYVQNLSLAASSRLLQLLSSMSTPSFVLANESNHTLLQALLEAISTMIEHQYTSNSNLIYAVWRSRKRIEGLRAFTLDGGQAEIERVAQRRKESSLTDVTNNLSRSSTLTDMHTPTHNGPVSPHTDNGVDGTFAIGDSDESDNEDAPTPSQSTQSMRTSRTPSIASSSAVDDHVPIQLSGMSEKARGKMPAGALAFSRQNSTTSLSGSSNYGGGRGSFTPTAEWLESWLVDLPLHTLLTVIKVLSAHPPVSSDRTRANFDGSSDQPRRSSNSNPSSRRQSFTNDEPSITEFRAQIPNTANHPAISAILASPSPIRVHLFEWSPLSLGWYMSVLWSLIFTAEMMITPASSTAATLTGAGAVAAPVGVWNGTNVKLFQVATEGRREGPSLSQPRGAVDAVGSRLVQGVQGLNLGGLVGRVGAAGRSVSFQGSNGNNNGRQGLRTREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YEM9</accession>
    <name>A0A0D1YEM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_08689</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233717.1">
        <property type="nucleotide sequence ID" value="XM_016383014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YEM9"/>
    <dbReference type="STRING" id="91928.A0A0D1YEM9"/>
    <dbReference type="GeneID" id="27335772"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08689"/>
    <dbReference type="HOGENOM" id="CLU_010060_1_1_1"/>
    <dbReference type="OrthoDB" id="406864at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002246906" description="non-reducing end alpha-L-arabinofuranosidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="544"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW13501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="739" mass="81607" checksum="BBB3AE8BE64E84D9" modified="2015-04-29" version="1">MFSSSVLVALLQLSTSAWGRSVVKAPVKRQSYDFINITQYNSTPGPVELSVSLNAGGRNQTAPLLYGWWVAFYHVSPYVILWLIRGRMHEDISHSGDGGIYGEALVNRAFQGSGAIIGAVQGIPGSSVQYSENPILPWGPVITGWRGIGGVNLSLTLLHPLSDALPIALQVDIPWDATGEVGILNEGWWGIDVRPGTYNASFYILSNKPRNNGTLSHIDVSLRSNLTDDVWSSSSISFGEGQNISSFEWTQYEVQLGNTVKAPNSNNTFAITFDASEVAGNTYYFSLVSLFPETYKNRPNGIRKDLGEAIVNLGSKVLRFPGGNNIEGYSIDQRWKWHETIGPLKDRKGRVGDWGYTNTNGLGLMEYLEFCEDGGIEPVLAVYAGFSLDIWGQDGVSFPEDRMGDVLQDILNELEYITGDTSTHYGALRASHGHPEPFALKYVEIGNEDWFSSTYPYRFPILYNGIKQAYPEITLISTAFDENDDYNITIPAGGMWDTHHYEEPSYFIEHFDFFDNWQESTGNTDVTVFIGEYSVFQVDTPDGAVNYSMPLGKHIFYPTLMAAIGEGVYLLGAERNPNVVKMTSYAPSLVNLNWQNWTPDLVAFTANHDETVLSASYYSQQLLASYRGTQTLPVTTNQGDYNPLWWVATATEGDERVYFKVINSGNSSVPLTVNFDEGFSAVNGTILTHPDIAAFNYIGNATAVSLAPITDLPAASAGETTFTWAVPPWSVNVLEFQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YG50</accession>
    <name>A0A0D1YG50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">beta-glucosidase</fullName>
            <ecNumber evidence="4 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_06767</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234202.1">
        <property type="nucleotide sequence ID" value="XM_016381100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YG50"/>
    <dbReference type="STRING" id="91928.A0A0D1YG50"/>
    <dbReference type="GeneID" id="27333850"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06767"/>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="12">
        <location>
            <begin position="391"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW13986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="839" mass="90684" checksum="A30756ABA6DAB4EA" modified="2015-04-29" version="1">MGSYSGSQQGFESIISGLTVEEKATLLSGADFWTTSPVTRVGIPALKVSDGPNGARGGHFQGKTTSACFPASVSLAASFDREFAYKIGRALGQETKTKGAHVLLGPTVCHHRDPRGGRNFESFSEDPLLAGELASEWIAGLQSEGVGATVKHYAVNEQETRRFTIDARVDQRALREIYLKPFEIAVKRADPWAIMTSYNLVNGKHADEHKELITDILRGQWGFKGLVMSDWGGTNSVAPSLNAGHDLEMPGPPLKRTVDNIQRALQTGELTEDTLNQRVGNVLKLLQRAGKFENPEIAEEQAVDLPEHRSLIRQAAAESMVLLKNTNNILPLKSTNTKSIALLGLAREYLGHGGGSASVNSHHKVTAYEALQAAVGSSVQLNYAEGARIVRNLSPLSENVYNEEGVPGFTMKTFSKLNGDNPTVSTVPSSVYRTLEPSSIDQMTLLGTFKPKTSGLHYISLSTLGGTRVYINDELVFDYSNSQTTDIMAFLIGSPGEDKKRYLFTAGESYRIRIEAKATKDTISGFSLFTKEAIGFSLGFALESEHDADLLTAAIEAAKSSDVAVVFVGHTPIWESEGADRSGMDLPKDGSLDALVVAAAKVNPNTVVVNSTGSAISMPWIEDVAAVVQAWFPGQEAGHSIADVLLGKVTPSGKLPVTFPRAITDVPSYENFPGDIKNEVVHYKESIYTGYRHFDRRPEGVLFPFGFGLSYTTFDVVVTSVSRTKLRNHETLTVSADVTNTGTTEGAEVVQVYVGAGEGTSAIDRPAKELAGFAKVHLRPGEARKVAITFGRDSVAYWNESRDKWSVDKGAYTIYVGTSSVDIAGKLEVEVPEAFDFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YGL4</accession>
    <name>A0A0D1YGL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_06917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234352.1">
        <property type="nucleotide sequence ID" value="XM_016381250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YGL4"/>
    <dbReference type="STRING" id="91928.A0A0D1YGL4"/>
    <dbReference type="GeneID" id="27334000"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06917"/>
    <dbReference type="HOGENOM" id="CLU_017718_8_3_1"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="91"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW14136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="467" mass="53313" checksum="3E1272F3BAF04047" modified="2015-04-29" version="1">MADLIPNTAAVSPNGVRNSPSPSVPNGKPASPYVKESNPMGANAAQTVTSKDPKAAAAAANDMRNVVRRKLTGYVGFANLPNQWHRKSVRKGFNFNVMVVGESGLGKSTLINTLFNTSLYPPRERKGPSLDIIPKTVSIQSISADIEENGVRLRLTVVDTPGFGDFVNNDDSWRPIVENIEQRYDAYLEAENKVNRMNIVDNRVHACVYFIQPTGHSLKPLDIEVMRRLHTKVNLIPVIAKADTLTDEEVALFKQRILADISHHSIQIFEGPRYELDDEETIAENQEIMSKVPFAVVGANYEVTNPEGRKVRGRRYPWGIIEVDNEEHCDFVKLRQMLIRTHMEELKEHTNNVLYENYRSDKLIQMGVSQDPSVFKEVNPAVKQEEERTLHEQKLAKMEAEMKMVFQQKVQEKESKLQQSEEELFARHREMKEQLERQRAELEEKKTRIEQGRPIEKEGKRKGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YGT8</accession>
    <name>A0A0D1YGT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234427.1">
        <property type="nucleotide sequence ID" value="XM_016381325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YGT8"/>
    <dbReference type="GeneID" id="27334075"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06992"/>
    <dbReference type="HOGENOM" id="CLU_930765_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW14211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="299" mass="32649" checksum="8CD59A97D30941BF" modified="2015-04-29" version="1">MADFNDNFFIQSVLNSIDDLNQIDRVVAAELGLPPFPSFEDLLRRGWRPSSAHSNPAPATSSVGVPQRQSNGPNSDQQNGSQSAAVAQRGPPAIRAVHPRLCPRPLAPSHRPSLAHANSTPAQQGVIGRARATKRKSPDDEEEDIPANGGEPAGKRQSLGGAKLVGTTKELPGFPASKEPLPTDWTLELVVTKYPNHTLLPSVLDAFTQYFWTGNDIYKRFSPEITQEWNKVFPNQPGNALHKRLIGRWKKMGSAALRDLINAPKIVPCFAIGEPYFGKSNPGNLDLNPRAPRKPVKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKC4</accession>
    <name>A0A0D1YKC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05472</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25325"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:25322"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoethanolamine + S-adenosyl-L-methionine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20365"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58190"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20366"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235642.1">
        <property type="nucleotide sequence ID" value="XM_016379815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKC4"/>
    <dbReference type="STRING" id="91928.A0A0D1YKC4"/>
    <dbReference type="GeneID" id="27332555"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05472"/>
    <dbReference type="HOGENOM" id="CLU_060397_0_0_1"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="47"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW15426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="236" mass="25709" checksum="52C357FE949B0707" modified="2015-04-29" version="1">MSTPGARAGLETFDDLNIEYENAYRDNAFKVACVRKAISLVPPGSRVLDVGCGTGIPVSQMLAEAGLQVVGFDISPKMIALASTRVEGSFSVSDMLQYRPQGDFAAVFIIFAQLQLSYADFHAAAYKFARTLVPGGVFVIGQMPADKYVKNIADYDETGTFVEDYDAPFMGEPLPTFMLSAQGQRDFLASMGLDIVSETIDMFQPKNPKCDPEEQQYIIAKRTSGAPLQPPKPLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKS3</accession>
    <name>A0A0D1YKS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235822.1">
        <property type="nucleotide sequence ID" value="XM_016379995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKS3"/>
    <dbReference type="STRING" id="91928.A0A0D1YKS3"/>
    <dbReference type="GeneID" id="27332737"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05654"/>
    <dbReference type="HOGENOM" id="CLU_019318_0_0_1"/>
    <dbReference type="OrthoDB" id="5369841at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="60842" checksum="1D037FC4A9C1C95C" modified="2015-04-29" version="1">MESREFATKDELWRIQETLSELSATQAVHSDRIMRLEQKTSEGSRSRTLWGSASPFPGGLGSSHHESTLNPAAEAFRNFDVEPAASMMSSLTLDATDESRRAAASRANSVRFDESANNHYATSRQSIELPTRTGSGLGGHTLSERSLSHRSDGRPSVAGFGRTNSFGLEQSRLLGSIHNSPRVLGNPPPGFFILGPCPSIIRCWLTESFSNDSLLYAAICTGSSTSSVSLALVAKLDLLDSIFDDGEFRAIRLPVYLTEAKIHSPAVRSASPVPHVPTLTVKFVIDEQPVCETSIQIVLGSDVLRSHNGDILFSQDRLMIFDEERNQLSIPLVRPEDDASYKDLCTAPRRRAASIEGAMLPPPVSPVGVIGRPGRSNTAQMVASPRVAPSSSIPSATPSEPGDIRRSDLHAEQSTRSSLDLTPSRPADDSKSTTGSEKSFSTPMSKSGQGVWSNSWRSASSFTQNDQAPKTSSTYARPSVSRPMKILRPAKTMANATRTASTPIGTNGTDNPPKPDEFGRKASQTDLKDNARSAQSTSTIKSNPVGSGTAFGWLNTGPQRRTTANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSL0</accession>
    <name>A0A0D1YSL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238467.1">
        <property type="nucleotide sequence ID" value="XM_016376897.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1YSL0"/>
    <dbReference type="GeneID" id="27329622"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02539"/>
    <dbReference type="HOGENOM" id="CLU_002322_0_1_1"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="435"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1323" mass="151235" checksum="60F1313F16F838EA" modified="2015-04-29" version="1">MPTTPAHLGTKVDWAVDHLNSHWDLEIPKLHGIPARNAAGNDRLPFRCFSRIRMLTFRSIPIEDIIEEFDQKARAIHSKWVWKPSQEKGTLPLLTVSKSLIESEKRRSQVVNLTPSQRADLCQALFEFLDEYCKLAQLSESMSTERLSDTTYSTAPSTPSRRKDSTRTQGTLSTPRRDILREGQEPRLKNPGSSVKRSIPSPDSKSKRQQTLKQLDYFRPPPFVVKSEPLLPSNNRSLQEPTSFETTSTSRVSSIFDDCDEQKSDISHQTSLIEGLEELADPEKSQDLFPTQELEELLEDEDFRRSFHESSCLPNDIDAALSNTFPERRKLPSHVPFWLSWEIHRLADKADVLPFDLYNFVRRRCKTDLPTFEAYWEAAREYSKHNQVSTPPRSEIPSWMATENKYIDLNSARAIYLTANLAWRKDFPDGVFKLETNEIRLEQSCRLYRKFGADRFLVLTTPEFSQSSYPEALKARDSNADPMRQRITDFLTRKSHFIAGRYWRVFYVEPEKNKRRKDQPSRLKFFLFAESGYDMESSLSTIDPYSDLLNASARHQEIGIEVMAEWHLRFGANAKSKDLKLFSRWGLGLSKTTPTIVLDRKEFVVRHDPPSAPIMDDGCALISLQLAQAIWEKCGGQGDVPCAVQGRISGAKGLWIVDFHNRHPGISDREYWIEVSDSQLKIKPHPRRRKRDDADLRTFEVLKWASECKPGHLNIQLITVLEDGGVPRQALENALVADTLSFSESLTAAVKDKGDGRLLYLWMRSNGLLSPSEAQKVLGTFPYDCRQQLTLLLESSFNASESAKIKKCVKTLLTNYMANYVERLWITQTSSTTVFCVPDPTGKLKNDEVCLNFSRAIQDPRNGMSELVLNDIDVLVARNPAYLASDIQKRKAVYIHELRHYRNVIVFPTTGTRALASMLSGGDYDGDTCWVCWDPAMVEHFHNSDLPALPDQGRCGMKQESRPLREIFTKDRPIEEAMQDFSQTCMRFNARPSLMGICSSEHEKLIYSLSQRQKEQKLSHPGAIKLAALASYLVDSSKQGWSLSETSWFSLRADASGRKQLPIPAYKEGKAPRRQGGEFPNVVDFLMFEVAEREKDRTLAKFQKLNPGAGVYDGVLSVTWKEMWEDALEEKKVWEKKTGHGSRGVNSYAKSRVPVNEQEPARGLGIYLICDNLKQRIAEVQQRWKEVAPAEDSSDQAKYNYAVRQIHELFLAIEPKQIDHVIRRQYEKEKTRHFSSWSLLRASCLHYTVCQRGSFPEWVWYIAGRELCHLKAMSHGGPVRLVAEDILDIMKVGSKFAKALVERQSMDDEEIDGEELVDDVDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWB3</accession>
    <name>A0A0D1YWB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239767.1">
        <property type="nucleotide sequence ID" value="XM_016374491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWB3"/>
    <dbReference type="STRING" id="91928.A0A0D1YWB3"/>
    <dbReference type="GeneID" id="27327206"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00123"/>
    <dbReference type="HOGENOM" id="CLU_035066_5_0_1"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000029">
        <property type="entry name" value="CDP-alcohol phosphatidyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF77">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="423" mass="47459" checksum="B1C2BD035948370E" modified="2015-04-29" version="1">MAESVDPLSDQAMVHLMAYKYQSVDKSFISNYILRHYWNGAVKLLPMWLAPNMVTLLGFICILVNVVFIQIFIPDLVGPGPTWVYYSFAAGLWLYSTMDNIDGKQARRTGTSSPLGELFDHGIDSLNCTLASLCETAAMGLGPSKTGAFTALVPCLPMFFSTWETYHTHTLYLGAFNGPTEGLILACAVMILSGYLGPQIWSHRIAEYVSLPEKLPFDIPSDLTFRDLWVPIILVAFFTAHIPACVYHVARARHQADLPLLPVFLEWAPIIIFTGCCMAWLGSPYSTLLAENHLVIFSVTMSFVFGRLTTKIILHHLTRRPFPYWTSSMAPLVGGAIMAWLPLFGQKPVSPTFERLYLYAYLLYAMALYFTWAVRVINRICDVLDINCLTIKRKEADTKDAHAFSNHARSTSNGAVRKTMKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWE7</accession>
    <name>A0A0D1YWE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239822.1">
        <property type="nucleotide sequence ID" value="XM_016374546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWE7"/>
    <dbReference type="STRING" id="91928.A0A0D1YWE7"/>
    <dbReference type="GeneID" id="27327262"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00179"/>
    <dbReference type="HOGENOM" id="CLU_032482_0_0_1"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="60"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="457" mass="49145" checksum="390CB410EB49260F" modified="2015-04-29" version="1">MATSPPRIVKFTNGYLLKDGQLVSGDLWVSSDTGRIMSPQTAFYSSRLTADKTVDLQGKILAPGFIDVQINGSHNFDFSTPSPEFASGFAHARKQMIKSGLTSFVPTVISTRPEAYHAVLPHLGPSGKTRDFNEGCESLGAHIEGPFLSPLRNGVHNPEVLREANSWADVEECYGSSNLENVRYITAAPERGQMMSLIPKFVSRGIVFSVGHSDATFETAQNAIAAGASMVTHLFNAMRPFGHRDPGIFGLLGQSAPTTPVTSPKQSRPTSTSSSPEASPRSSRRSTPRSSLSISTSVDDLDEGARYRQPFFGLIADGIHLSAQALKIAYSAHPRGAILVTDAQKFAGCPDGVYDWRGEDRFVKEGKLLKLESNGRIAGSVVDLIDCVNNFKRFTGCGTAKALECVTSTPAKMLGKDVEASKGKLESGMDADLVVLDETPDGELTVQQVWKFGVQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWT9</accession>
    <name>A0A0D1YWT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_00350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239992.1">
        <property type="nucleotide sequence ID" value="XM_016374716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWT9"/>
    <dbReference type="STRING" id="91928.A0A0D1YWT9"/>
    <dbReference type="GeneID" id="27327433"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00350"/>
    <dbReference type="HOGENOM" id="CLU_006696_2_0_1"/>
    <dbReference type="OrthoDB" id="635774at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF291">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="343"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW19776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="976" mass="110336" checksum="446A9AE049DE02C3" modified="2015-04-29" version="1">MGIRPQYAEEPLRQLETEPHLPKHSLKSGMWQKIHKLFVKDDPTDDSVDFTEDRRWPETTPDDDELSRQDSTTRPLAIGLPRQATFRRQNSERRDRLLPVKPCHAERRALSAVRHTSTSLPRPRATSSPPCWGPGRTSAPAVALTSRIDAPAADAGFDAITSSLDPALVSNTEDIWPQDTFRPPRPPSTTSSDDSHFLRMPLVDDKADLRDELDTRWILNLSMHFRDKSDREKFFVTYAETPSRWRRVTVSCDYRNAEPGSLEMDLKELQFQRDKSMQIYESIRDSLPEIQFYDTVTNLKLETTDGRLHVHVTEDVNEIIPYPPRHTLGHILHDDEFQPMVIRESELIFDSHISGFVYKVKHKNKVYIKKDIPGPDTVDEFLYEINALHALHGSSHVIQLEAIVVDDEEQYVRGLLITYAEKGAVVDLLYDHRGAIPWEDRCRWAEQATCGLSEIHEEGYVQGDFTLSNIVVDGEGNAKIIDINRRGCPVGWEPPEIAAKIASSQRISMYIGEKSDLYQLGMTLWALAMDDDEPERHVSPFSVDEFPSEVPEWYQDIVRICLSRRPRDRCSAKTLAKMFREGDTKPPHSKERHERPTLKLRTPQDYIDPADAVGRDDIERFSNQHEITDVPYSPESSRDDYTFTYPRSSNYEIDSETSAYDRPRGRAPPANYAHLGRNERHHWIGDDDRPTLVDDAEPNIVPISPGMEHEFDKVELDGHPYLVPRRTFNDEELEILERAAEAQQTSQDSVSSANFVTPGQIDHPLARDASLSRRPSVVTTCSMRSDSTPRNSHAVLSASTHQHYGELTSEPEEIRDQGLPIEGSATPTDDHNAAATAHPITNSDGPAVAIPSAPDRLPRLPFADSGYDDSFDADGDLDLSVQTLTTTREEKGEEPKTDSATPEIDRELMTTPEAVGTEEISDEAQADTQPNRLELARSDHLAVPDSQVARQQELNRSEQTGQSNQVTPPSMQDVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYG3</accession>
    <name>A0A0D1YYG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240547.1">
        <property type="nucleotide sequence ID" value="XM_016375271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYG3"/>
    <dbReference type="STRING" id="91928.A0A0D1YYG3"/>
    <dbReference type="GeneID" id="27327989"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00906"/>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_1"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="148" mass="16768" checksum="E6B78947046A46BD" modified="2015-04-29" version="1">MPREQSDEAQWWFQAVYSAVQQIPFGKCTSYGHIATLLGYPKRARQVGICLKHLPSFDPAEPDKWFYHDHNVPWQRVVNSKGGISPRGDGGEAAMRQAERLRAEGVEVGDARGVEEMSVDLGRFGWFPKRLEGDDQSESETDDENEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYR5</accession>
    <name>A0A0D1YYR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_01006</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240647.1">
        <property type="nucleotide sequence ID" value="XM_016375371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYR5"/>
    <dbReference type="STRING" id="91928.A0A0D1YYR5"/>
    <dbReference type="GeneID" id="27328089"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01006"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW20431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="147" mass="16553" checksum="40E5F14ABE97C9A0" modified="2015-04-29" version="1">MALKRINKELTDLGRDPPSSCSAGPMGDDLFHWQATIMGPSDSPFQGGVFFLSIHFPTDYPFKPPKVNFTTRIYHPNINSNGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKTDRARYEATAREWTRKFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZ27</accession>
    <name>A0A0D1YZ27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240717.1">
        <property type="nucleotide sequence ID" value="XM_016375441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZ27"/>
    <dbReference type="STRING" id="91928.A0A0D1YZ27"/>
    <dbReference type="GeneID" id="27328159"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01076"/>
    <dbReference type="HOGENOM" id="CLU_1061865_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="262" mass="29078" checksum="631C7D0B5617C2B5" modified="2015-04-29" version="1">MHLAFWPQRDPRGRLTQGVVDAIENSRIYSPRIREELLKSSYRKEGSITSKYWKKDSRDDVDHKKGERLPSSTKKASQKIGYEPAYKARQPFDNLALGRPPTPKPRNLLSRRASSMPPMGCTEVAGSTFDSSGTNDDSDHVEHSNLAGRDALQHDDPPVAASPEISSSAVHARTITPTDARRNSHSGSRLRPLGNGKRLKRRTGTLSNGRGKKQNRGSIFDLAEDDGDNETRPPASSTATLVDRPKQSVSKKCTPRKLYLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAE1</accession>
    <name>A0A0D1ZAE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230178.1">
        <property type="nucleotide sequence ID" value="XM_016386046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAE1"/>
    <dbReference type="GeneID" id="27338821"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11738"/>
    <dbReference type="HOGENOM" id="CLU_394328_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="699" mass="80333" checksum="B3C11B7F3F917158" modified="2015-04-29" version="1">MSRREYRDESNHIGRPRRPDNYGPRFEARSPYQRTRSSSPRRSSGQGHGDLHADDDYERRHRRRGRYSDSESSGDERRRALEYERRQEQRRREYVELERLQSERAEFERRHGNAQQSGSHRQYGHERSNESEVEQRSTPNSFGDSRGRGRRRNHHGRGGRDTPRGRGRGQGSGRGRGRGQGGGRQHQSPHENEPENSQPADPLVERLRRSHARLVAKSGLSEERKKELEEELAQDLADFIATRSNSGSTVGNQTTGEVSQPATKLAAQETQNASVQEVNQADKEDHRMSNTTEVAEQSLASNPEASMQPTPDQTAQEVEALRGQLARVEHLVVQCQAQNMSTEQKFGILPAVFQAIEDIRLANEANRVDAQFLNNRMSTGFEVTAQILAEHNHQARLTNQNVLYMGEQIQQVRDDVMDVDYTHEQRYNLMMEGWRKYFLYHQQVIESGPLELEYDLATLEIQDRPLRQLMAPERADTEVARVPVTDSNPTAMTNDKGRQCDDPTVEAKAQQETWLQEIRNYWHNYSANLQNVGEVVKQVLETHYQGDEFQTEEFQGHCTAFATYLKGIRDDIDPFWNECMLLHISAWGSYGDIPQEATEQQKQDEYGIAMNKSNAAKSQLEQRMKEVAKAIRNDGIFMIAKFDGVDERTTPEVFLARWRPVYHKVLQLLGLQDSNEPTFEPEDVLLYCGEKNHTVMDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZC20</accession>
    <name>A0A0D1ZC20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230743.1">
        <property type="nucleotide sequence ID" value="XM_016385799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZC20"/>
    <dbReference type="STRING" id="91928.A0A0D1ZC20"/>
    <dbReference type="GeneID" id="27338574"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11491"/>
    <dbReference type="HOGENOM" id="CLU_006836_1_0_1"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="886" mass="98061" checksum="437E065F70CD3403" modified="2015-04-29" version="1">MVKADVKRDYYADLDLPSTADAEEIKKRFRYLAKQLHPDRNPGHEVEVVPKFQAVQAAHEILSDPVEKAKYDAARAKMAARNAAAAATNYTDPYGFARPTPTKQTATPQFPFPPPPKAPQRGMPQQASRGADKFNAFTRSAPQSWDRARFDNARADAARGFPNMRTTHTNQKMPPTAPRQAPTAPKPSPTSEVPHVPNVPPTTFPGLSRTASARKQGYTPGTHGTDDQQAPRSAYAYVRGTRGPPPPSAPMYNQDGTPLQSPPVSRAWPGASPLRPTRSTDYDMKQDFQDGSRPSSRYAGAGGERTDIHGDTMHHRSSSVRNSPIDRHWDAPGPFGKPASNFEHVPRHRSASPGMRSAGRHAEFSSDTSSDEDEAYNVNTRPKATPRSRPRPRTAAFADNPGLTGSFPSTNYTRIVNDSKHQFPSSDSRETPSKPFASEPFPATEEHKTSDTHVNGGQEEVSDGPKYARSRTFSYPWWTQAANCPRSTARGLSFNGLPSWAVPASVFPRTSPAGRKRADPFVTAQTPIPKRVFPHSEEQADPSHSHEPQPPSKFSADEWHEKLNVDDIFRPTDSQMRKSPSKLNRNGSKPATRGRGMSRGVDQESSSSADRAEDSKAKAAAFQKGKLPPDWGSNVKPTPPPGDTRTASDRTSHGSHSTDDSRDQYVVVEEDIMDVDDTPPMKAASNPTRSSPFEAHSTKRRSSPDGGVNLREFTQQAPFAPTAAGLKGLDDLAAHLPFESKPEDKYEKAPTRLRALNLPKPPKVVIPPAADRLDKANFLQYVDNMNAYMQDWNNFNATMLDHFKARHNRVCGTMSQSWVSMLWDGPDADKIDENGTQKAGYSAYLQWLHDDAQCRQWWDHANEKHLQCMEDLGRVREVARRKFRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZCT3</accession>
    <name>A0A0D1ZCT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_10141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231058.1">
        <property type="nucleotide sequence ID" value="XM_016384456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZCT3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZCT3"/>
    <dbReference type="GeneID" id="27337224"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10141"/>
    <dbReference type="HOGENOM" id="CLU_095071_2_0_1"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW10842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="134" mass="14779" checksum="3D70F9983771EB0D" modified="2015-04-29" version="1">MIQLKTLLNCIDNSGAAIVECVQVMRKKTQHARIGDRIIVVVQKQRSFGADNPGGSSLGIANKVRRGDIRHAVVVRAKKEIQRKDGSLIRFDDNACVLINRNGDPIGTRLSSMVGAELRDKKWSKILSLAPLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZGD9</accession>
    <name>A0A0D1ZGD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232238.1">
        <property type="nucleotide sequence ID" value="XM_016383615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZGD9"/>
    <dbReference type="STRING" id="91928.A0A0D1ZGD9"/>
    <dbReference type="GeneID" id="27336379"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09296"/>
    <dbReference type="HOGENOM" id="CLU_792347_0_0_1"/>
    <dbReference type="OrthoDB" id="4133437at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="324" mass="35486" checksum="74A70512C2DEFD11" modified="2015-04-29" version="1">MGAVLVIGYPLFMGALAASIYGILSLEHKSNERSLTEKDVQHTGVTLALVNGFMSWGEDSAIALTWNGGEPTTNKDIEEVLVPITSDDKAVFHHWNDTLPQWISVKNRGASPVCLAGVSIQKDDTVMTLAGDLGRVCGAEYYESSRFVLPEDQHTQAPSCTWIDANHPIRFNLAGNDNNDNDDNNVVRDPTDLCKAPFMTWAPSDKGAGAGNQQRGIEDASPFDGILVKSSRPLSSAVRLCNSVMAKGPSFVSEPEELYCDMTTKTLYPVCKEGTQGICFDDNEDELIDNDAPPEIRQRGFDAAPKSLEKTRVLKAFRDVRKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIE6</accession>
    <name>A0A0D1ZIE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_09920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232858.1">
        <property type="nucleotide sequence ID" value="XM_016384235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIE6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZIE6"/>
    <dbReference type="GeneID" id="27337003"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09920"/>
    <dbReference type="HOGENOM" id="CLU_039456_1_0_1"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="132"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="230"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW12642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="34097" checksum="36B64309AE6BE47D" modified="2015-04-29" version="1">MAATLPPSSTGSTKLDAAVQVAKANEPQKLSGFGLYSRFAFAGAVCCAVTHGGLTPVDVVKTRIQLDPVTYNNGMIGGFRKVIANEGAGALLTGVGPTFAGYFLQGAFKFGGYEFFKQQFINQLGYETAANNRTAVYLASSAAAEFFADIALCPLEATRIRLVSEPTFASGLVSGFSKIAKTEGFGAFYSGFGPILFKQVPYTMAKFVVYEKVAEAVYRSVDKNTASDGTKTIINLGSGLIAGFAAAIVSQPADTMLSKINKTKGLPGESTTSRLVKIAKELGLRGSYAGIGARLFMVGTLTAGQFAIYGDIKRVLGATGGVEIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIT6</accession>
    <name>A0A0D1ZIT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_07959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232988.1">
        <property type="nucleotide sequence ID" value="XM_016382285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIT6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZIT6"/>
    <dbReference type="GeneID" id="27335042"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07959"/>
    <dbReference type="HOGENOM" id="CLU_069859_0_0_1"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="85"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="337" mass="38859" checksum="B4D6A93F725E686C" modified="2015-04-29" version="1">MPSNLQYTELSSRAQQAVDDFIPPDDIVQKRSRHFASVQPRAEDSEGDKEALDGVEFTHHFVDAPGDHECVRFHYVEAGPKKGEVIVFLHGIPDSWYQWHHQMATLSATYRCIAPDLKGYGQSEKKAGDYRHEGAADNLFSMFEAIGLATTKFNIVSHDRGTVQADYIVAKHPEAVLRYGRGEQHLYHFNPVLAPQGDIFMNAPWTGIMEDPKHFVVWVYTWVAKQPIPDDQFARIIQEYSYPLVSRAVPRYFNSSTFRAEWLDRRNRLLEKWKCPVFIMQGYDSRTQPREFYEDAREYIPNAKEVQVKYLPGGHFWTMESPEETTKAIQDLLAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZLM8</accession>
    <name>A0A0D1ZLM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_08933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="235"/>
            <end position="277"/>
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    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="282"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="326"/>
            <end position="360"/>
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    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="383"/>
            <end position="417"/>
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    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="436" mass="48942" checksum="208E55E518EF8702" modified="2015-04-29" version="1">MADDEENLSEELNNEDAETEQKIINEEYKTWKKNAPFLYDMILSTALDWPTLTTQWMPDVHDVPGTNYLKHRLLIGTHTSPGLPNYLEIAQVQLPKPKKPDVKDYNEETGEIGGYGGGPAGKNQLEVKFNIIQKIDHPGEVNKARYQPQNPNLIATMCTDGRVMVWDKSKLSGRPSGTPTPTIELHGHEREGYGLSWDPRQAGQLATASEDSTVRLWDITQASKANNVLKESRKYTHHNSIVNDVQYHPNLGNMVGTVSDDMTMQILDLRQSDTTRSALKCDNAHRDAINAIAFNLAVDQLVATGSADKTIAIWDLRNINHKLHVLEGHNDSVTTLEWHPFEESVIASSSYDRRIMFWDLARVGEEQTPEDSEDGPPELLFMHGGHTNRISDFSWNKNSPWVVCSAADDNLIQVWKVAEAIVGPDDEDVPMNELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZLW6</accession>
    <name>A0A0D1ZLW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formyltetrahydrofolate deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016380951.1"/>
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    <dbReference type="GeneID" id="27333700"/>
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    <dbReference type="Proteomes" id="UP000053328">
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        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:amino acid metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
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        <property type="entry name" value="PurU"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706:SF1">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036480">
        <property type="entry name" value="FormyFH4_hydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW13837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="281" mass="31328" checksum="E9850AA8AC1E00A6" modified="2015-04-29" version="1">MANDHILTLSCPDKPGIVHAVTGIFAQNSLNILDLQQFSDRDSEKFFMRVHFGPADTTGFLVPEFDALAASMQMDYSLRPVSQKPNVLIMVSKIGHCLNDLLFRQKTGQLPIEVPLIVSNHPDFEPLAKSYDIAFHHLPVSKDTKAEQESRILELIAAHKIDLVVLARYMQVLSPKLCEVMSGKIINIHHSFLPSFKGAKPYHQAYDRGVKIIGATAHFVTADLDEGPIIEQRVARVDHSMTPKELVDEGSNVESQVLAAAVKWVSEQRVFLNGHKTVVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZNA6</accession>
    <name>A0A0D1ZNA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_07109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234543.1">
        <property type="nucleotide sequence ID" value="XM_016381441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZNA6"/>
    <dbReference type="STRING" id="91928.A0A0D1ZNA6"/>
    <dbReference type="GeneID" id="27334192"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07109"/>
    <dbReference type="HOGENOM" id="CLU_026278_0_0_1"/>
    <dbReference type="OrthoDB" id="4121132at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002248030" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW14327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="389" mass="41869" checksum="5116DADCD7DE2BEB" modified="2015-04-29" version="1">MVSFIQAVTAVSILVKACLAANTAIQIFNGPYGVGTATAELINTKLLDPYAPTKQDRRLMVSAFYPVAEIADCQHTNISYMPAGTAAVYDQEYGAAGLPNGTFEALHLALCGNTLSQNPPKNKYPLAIFSPGLGFSRLIYSSFAASLAALGYVVVTVDHPYDADVVEFPNGDLVMAANINDSDVSQLDTAVAVRTKDLSFVMDQMRNRTVTRSLLQKVYGKMNPSQTFVFGHSIGGAAAAETMLQDHRPLAGVNLDGTLFGQVVSEGLDKPFMFFEHDGKNQSTEATWASIWTHLNSSKAQMTVVGSQHGTFTDFPIIVDTLGLRALIPSQELTPLIGSVKGERILTIVTTYVNAFFQFVLGHPPAPLLQQASPKFPDVVVANSTLTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZQW8</accession>
    <name>A0A0D1ZQW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016379591.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1ZQW8"/>
    <dbReference type="GeneID" id="27332330"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05247"/>
    <dbReference type="HOGENOM" id="CLU_252507_0_0_1"/>
    <dbReference type="OrthoDB" id="3918840at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008626">
        <property type="entry name" value="Mediator_Med15_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05397">
        <property type="entry name" value="Med15_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit 15 KIX" evidence="4">
        <location>
            <begin position="102"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="581"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="758"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="831"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1104"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1248"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1331"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="509"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="586"/>
            <end position="615"/>
        </location>
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        <location>
            <begin position="624"/>
            <end position="642"/>
        </location>
    </feature>
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        <location>
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            <end position="689"/>
        </location>
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            <end position="768"/>
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        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
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            <begin position="831"/>
            <end position="854"/>
        </location>
    </feature>
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        <location>
            <begin position="862"/>
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        </location>
    </feature>
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        <location>
            <begin position="881"/>
            <end position="897"/>
        </location>
    </feature>
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        <location>
            <begin position="1144"/>
            <end position="1154"/>
        </location>
    </feature>
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        <location>
            <begin position="1161"/>
            <end position="1180"/>
        </location>
    </feature>
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        <location>
            <begin position="1248"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1346"/>
            <end position="1376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1454" mass="162507" checksum="BFB62B7250AAC9C1" modified="2015-04-29" version="1">MNPQQFQNMAGLGRGIPNNMQQMAMQMGGQMGTQMGAQMGAQMGGQMGAQMGGQMGGQMGGQMRNQMPGGMPQRAGGQMTLNHPSVQQHIFDFLNSQGPYTGWQANVSVRERAGQVKLLVDSLRLVQPPVELLRAIEVALQFERNCFTQGASREDYVRACSDKLGRIRDWRAQQMNQGGTGAMKGMQMPMQQNMQMPNQNFAQIQQMQNMNPNMGIPPHLLQQQMQGSPMMNQPQQPVKPAPMNQSQPGMQMNMQANSQQKQAQVAELTADDNKAINLRAAELAKSTPKEEMRSIVEKMNPQLRQNLSQKAVDPIIYYFRMLATKEFRRAKQLEAGVAPGQMSNNGNLMTQQQNQPKQANQVINGSANMMGDMGRFQGQQAEGLRSQGEGELVVPASTAQGMIPEQMRLQQQMMANQQRGGQQGQGNINPAFMAQQQRLQAAQATKMQQAQLQAQNQAQAQARAQAAAAQAQMANQRQSMPQSNTPLSTINRPVGPNVSGASPAPPVARPVSNTPMLNQQQMQMNTGMQQQGQQQQSMQLEQHRREQALANFPAPLQAILRQKPQSEWKNILTQFQNSGNMRRSLSQQPQGMQNQQQQQQQQQQQPSQVPQMQNGAFLGGNNVGGTQMMQSLSQGAMSQQGDLNAMQAQMQQNQEMMRQRQIAMQQQKQQQPQQQQPQNQGQPQASRQQLSPQQMKVMDQQPVPPAVFNNIRQHAPVPEMRTWYQLKQWLIQNPVPNWPVSHVLDIQASHFAHIMRTRGQQQQNNGMSQVPQPQQPQQMPQAQVQGTPAQPPMAPGNMRIPTQADIQKVRAANPQLANKSDDQIRGMIVQRQRQQFQKAMQQQGGGQAMSQPMQFSASQHAQQFPMQPPQNQQTQAQPRPTSGQAGSQPRPSPSQGDSKAIKRPSGDDDIIEITNHAFNKPPQQQTENKFPQLSKEQYNQLDPAKKHQYLNLQREQQLRKRIYEIMKEVQSSMPKLRPIPNMDPASKERLTRMLTSDNVKNMVGRFDAFLVACYRMDQNEATLKQLTTQKIQLMSQYKPDAYQRKSFEVVDNFSITPDTAEVIIGNIMSKFQQTVATIPQNKARAQPAQLTEENMNLLQAQEAERKKALKANQAPPAPTSSQPPFQLGDKGQGAPAWYGTPGLKQEDLKLPADPKRRKKNQPQAAGSTPPVVTSPQQTKTPKPAQTFKCPVQGCEHQLKGFATQAELDQHHNVTHRLDMEPVTDPLAFLKDSLRSALNLDENMKQIKKPKTESKAGIVKEESAAGNSSSKISADEINVNDDNPWAHTNITLDQMRVAFGGDEWEELFPTQEKIQESESKFYEAYRNTSERWRKINEGPNGALTDTSTDKSKSPETSDKELPAAKDKNAEPVKKEDDPWVVSLEGIEGLDLSSLDDMSPFENIADYDAGIGGSPFEQVEKPLSTEQQFLKMHGIDLEHPESWSQSQRELAEFAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWW3</accession>
    <name>A0A0D1ZWW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">REM-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_04373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237398.1">
        <property type="nucleotide sequence ID" value="XM_016378721.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1ZWW3"/>
    <dbReference type="GeneID" id="27331456"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04373"/>
    <dbReference type="HOGENOM" id="CLU_001013_1_1_1"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
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        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="4">
        <location>
            <begin position="113"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="6">
        <location>
            <begin position="244"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="5">
        <location>
            <begin position="682"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="7">
        <location>
            <begin position="1091"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW17182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1305" mass="145982" checksum="662C48D949748FFF" modified="2015-04-29" version="1">MASSDQGSGYSVTPTQGKGFTFRHSSRKSDDLSASRRPSIKDGRSLSGGSSHYGPKAFMAAMTSANPPGSFSADLKSAMQSGRTTPQSELAAVQFSRHPPQYKDGDILDTSEKRQAAVRDKIAKEMKIKLGTENMLEALLSKNNKQTKEQRQRVEMELGSSNRKLAELKQELDQEIMRAQSPTTPPSKRMTSYFRGSPLRTPPSLAQSQENPLAESIDSESPTVVLTETLQQLEADGMQPDYYIERANTLVELLKRNPTLKYDLAWSVFSLRVQLMLLSESSDVVAAGYRLTRHAIADRKSLQTIRNLHTDELVILSLVKREKALLEREQAVKFVRAFLDVKDGVYEISRAVVRSLVAVAETPDDRLKDICLLTLAELLTKHTGLVVSANGMSTLTEALADGSFPAPEGLVAGFLQILDHPLQRRFLHTGREFEAMFAPFTDPLLLSGHEDRLKNCAQAISAMLKTWPGFLLLSRNGAAPLRSLIDSLVYPIPQSRDIVLELFFDILRIKPPSWSSSFLAGRRLTTYGRVNTAPVEQPSQRQIAESSAEGKFDLTYHFSAFVLAALVKADLIHALVQLVRIEEDLMLKRKAALLLTEVLKLAHHTLPESVSANIQVLGDLIPTLQDYGSETSATNMTLIYQIESINRTLNRTTGSLYGRGVRADELVAAPQAVERSRYTAMMDSDQFRQAMTDSQVTSHSQYVKWKWDLIHSLVEGPLTNPKRLEDAIKSPKFLKRLVGFYRPFKYRFSIIRNTRPNQRYVRTGCALMKTLTQTSLGLEYLTENKLLRQIAECLAQVSPHSGITSASPLFDRQHMAETLSGGYFALIGALSQSSEGLRLMERWHIMDIFYHLVRLKDRDDLVKALLGNMDYTLDSHLRVILSKALTSGVKDIRIFATRLLRRYAVGRVQYSSGLQDRASSHWALRLVLTQLYDPDIEVGEIAVKILEEACNQPRHLEYVVKCRPSLDHLGEIGAPLLLRFLSTSVGYRYLSGLDYITQEMDDWFLGRNDAYVALVEASILRAYLEGAPHKTQFSVDPALDPSEPGVAPPHFYRELARTQEGCKLLRQSGHFYEFASTIRDFRLDEEDAESLTKVKGCMWAVGNIGSMDLGAPFLEEADVVTAIVRVAEGAQVLSMRGTACFVLGLISRTLHGFEMLAESGWDTTVDHRGRSLGLCLPRNLEALCLKTVGSDAALRVATPEEDAKYKAAVTDDDPMRAKILKHIVEMGNSVMYKKAAGDLHALKVKHPTYFAETEMFKRTLVILESHHYRLQARHYILNLFNKGLMRRIILDEEMDEDDTTGSDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0A2</accession>
    <name>A0A0D2A0A2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238633.1">
        <property type="nucleotide sequence ID" value="XM_016377063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0A2"/>
    <dbReference type="STRING" id="91928.A0A0D2A0A2"/>
    <dbReference type="GeneID" id="27329788"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02705"/>
    <dbReference type="HOGENOM" id="CLU_012153_6_0_1"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF5">
        <property type="entry name" value="NADH:FLAVIN OXIDOREDUCTASE_NADH OXIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="366" mass="40675" checksum="4D3C7463A714CC48" modified="2015-04-29" version="1">MSISALAQPITLKLSGKVIKNRIYRTPLSEYASTYDENDIEKTGIPKPRYAEIYQELADGGAGLICFGNIPIDRNNLENYNNAVLDPRNPWDAVAAFTPAIRAAKSRGAICLPQLQFPGRQVPEFLNKHPKSASDVQLGPCLLKTYGKPAPLTREEIKELVGRYVWAAEVLAKAGADGIILHGAHGYILNQFLSPLTNKRTDEYGGTLENRARFILDIVNSIKAKLPSDRFVIAVKFNCQDFIKGGQSFAEQCVVIKWLEDAGVDFFDISGGTYESPAWRGNIMTELAERPSQKIRGSYFVEWAQELKKVLSRAVIGTTGGWRDSRRMAEAVENEDVDMIGLGRTLREDPAWVDKAIRGEVRVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0T0</accession>
    <name>A0A0D2A0T0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_02855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238783.1">
        <property type="nucleotide sequence ID" value="XM_016377213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0T0"/>
    <dbReference type="STRING" id="91928.A0A0D2A0T0"/>
    <dbReference type="GeneID" id="27329938"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02855"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW18567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="224" mass="24940" checksum="164BA12AC4421E86" modified="2015-04-29" version="1">MPLCGGNKVVQRKLVLLGDGACGKTSLLNVFTRGFFPTVYEPTVFENYVHDIFVDGIHMELSLWDTAGQEEFDRLRSLSYDDTQAIMLCFSVDNRGSLENVGTKWIAEINEHCPGVKIVLCALKCDLREEHEKEEDEPNTPPRPMIQYNEGLEVARRIGALRYLGMLPILLATSVALVYAGTNDFAECSAMRNRGVNEAFTEAARVALQVKPAKSEDDSKCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A4G2</accession>
    <name>A0A0D2A4G2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239948.1">
        <property type="nucleotide sequence ID" value="XM_016374672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A4G2"/>
    <dbReference type="GeneID" id="27327389"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00306"/>
    <dbReference type="HOGENOM" id="CLU_014597_0_0_1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="677" mass="76225" checksum="3F39ED5CE276B54E" modified="2015-04-29" version="1">MPPRSRAGCPRCRSMKIKCDETKPSCRQCLKRKVTCPGYKRPIKWSDKHEVFNAWRPKPPSARDSGPLPLNAVDSASATEPNLLVEAFQPTLRARPTQIAPTTSHSLVTDVVSSSQQTQPRNSNDPNHVPFPPAVNNDDNDRSTADILREDLREWLTSHEPLALLEQQDWTWTIEGSGLGSGEGSTFSATLDCWDAGPSQGSEFNQALVQYFFDNLCGIHSVLDDTAERFKALVRRYLSTSPLLHKSVVCMAAAHCFQDDESMLSTCLECHTAAVRSLSEAVFQIETVLEQSTDSPQKSALSDENMLRKLEETLLASIILGFCAPWSDPRDLGLPHLRGARKLCEYLVNYVTKDGREPEKALMNTDHHFLIGAMSYWEACMAFVVDQPKTVVHYLYQFCQPTKTTYIHMFAGISLPLLVTLARVGICVRQNRALRNMVGVGWKDRESYQILASEVTQDAIEVAEYALDYEIPADETFDTKTLGSSTYRQLKAFSQMCRFAILLELQRNFPSLLDSQFDDAEAATPESRPFPRTISLDRWYFELSGAILSHAQDIPEGSTCGLYQTILLIICGSVLRASKNTSSVFSRQRTLRDKAETHVLSTLARHEELDKRRAFIRRRLQSNCASFGLRQVFSRAELLLEDVWNEFDAGTGEGDDLRSSRHWIDVMADHKLETFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A6D6</accession>
    <name>A0A0D2A6D6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome recycling factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240568.1">
        <property type="nucleotide sequence ID" value="XM_016375292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A6D6"/>
    <dbReference type="STRING" id="91928.A0A0D2A6D6"/>
    <dbReference type="GeneID" id="27328010"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00927"/>
    <dbReference type="HOGENOM" id="CLU_057161_0_0_1"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="6">
        <location>
            <begin position="143"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="241"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="315" mass="34394" checksum="BA7DE5D92CCDEF4A" modified="2015-04-29" version="1">MSRRAKDTARILSDFVSLSRGHPSPRAAAAAPAPSLCLQCRRSRFFDDHTNPSTTRFRAAAANLEGSRRTFTTSSALLKKSSSSSKSSRKSPDVSSPKVNTHIPDNAATKNRDSEVDPYDFSELNAGIANAIARLKDALVRTRDAGRVTPDMIESLPVDLNVKGAAAHGTRAHHERAKLGDIASVVQKGGRMLQVYCSEESHVKPISSAIQASQHSLVPQHDDNNALLINVPVPPVTAETRQQAKEEAKKVYDKASQAIRNVRGDQQKKFRKMELGKMVIVDELRKAHKQMEDVVKKGQDEAKKVYEAAVKALGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A922</accession>
    <name>A0A0D2A922_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_01867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241503.1">
        <property type="nucleotide sequence ID" value="XM_016376227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A922"/>
    <dbReference type="GeneID" id="27328950"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01867"/>
    <dbReference type="HOGENOM" id="CLU_064550_0_0_1"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF18">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="210"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW21287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="372" mass="41628" checksum="25C26837610290E7" modified="2015-04-29" version="1">MSEPGAVLASTVTSIAALGFIPVAIHFNFFTLLNRIGPIATAEELTKASDAERSDEDKQHSPLWCLTLVEDTMFAMAGLGLVDLVDDRTFQANSITAHMVAVPSSLHGMLHFTTEPLWSAAFLMRQLRDTNFEYPFQENKTPTQYGYKMIGEERFVNEHTYSIMHMQGRMPSFSSFMEGKFDRFGSMPDRVKSFGYDLGSVLKSDASSIAVVDIGGGRGEMLLEVKKAFPHLKSENLVLQEDHPDQTNAEELTIQRWNFKDESPEPIKGALVYSLTHIYHNLSDLEALRLMKKVSQAMAPHSRMLVHEFTKNSTYGKMHATMIQLFAGRIRSSREWKQMAALVGLEVTFEAYPVAGEGLIEMRRLGSSDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASI0</accession>
    <name>A0A0D2ASI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_12083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847506">
        <property type="protein sequence ID" value="KIW09668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229884.1">
        <property type="nucleotide sequence ID" value="XM_016386390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASI0"/>
    <dbReference type="STRING" id="91928.A0A0D2ASI0"/>
    <dbReference type="GeneID" id="27339166"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12083"/>
    <dbReference type="HOGENOM" id="CLU_417392_0_0_1"/>
    <dbReference type="OrthoDB" id="4124765at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009970">
        <property type="entry name" value="HC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07382">
        <property type="entry name" value="HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="657" mass="72971" checksum="B5F8CFDE0159860B" modified="2015-04-29" version="1">MGNHQSNEVNPEILTSLRDLGSKLQNYDDTETKTLGDLVCNLTKAPSTLLEARPKLVKLFQAEYERQTTNSFEDVKAWLGTIKHNNQALSPHEIDLIAPMLRAWRLNEEQATSRLRDASQWIKDPSTFWGVTPQTSLKSNMDVVPHCLRYDEDYLRSDDTLLRLRRRVVREIICLSTTYEQVRVTGFTGGIKLVTEAIAAHKNIDTNKRNALYQEVKRCTTAGRRWLLLGHGVSLGIHKNVVDFERNPITEVEFDAAQQYCRQLDLFKGNILSTAWNAIVNWFLQSLYKEIVCDGVLLRLKCDLRRELRTNEETTEKETTAKNASGKQTTEKETASKKVSGKMTTEKETTEKETTAKKTARKKTAANKTARKKTAAKKTAGKKTAGKKTAGKKPTAIGTTIALSAHDESDNTGMFDNVSEIHHTQPSCHELIDRQPKRRRLNGVELVASGNSMDLNNFTQNAISETCSRRHQSSTGEGSPSDANSNAGNVTPEEQMDDAGAEDIEELRPLESSAFAGCEEQISGDYAGVRDELGSTAQELMADESCPGNDVPGMLMDFEHEYGGLDISLSRNNNPGSSNVCPGQFANNITGASINDTLPAQPVDFDPPSETSFMLPVETDYGTMMGFDFTPFADADTNFMHALDEADTWELGFPNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASI4</accession>
    <name>A0A0D2ASI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_12060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847505">
        <property type="protein sequence ID" value="KIW09673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229889.1">
        <property type="nucleotide sequence ID" value="XM_016386367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASI4"/>
    <dbReference type="GeneID" id="27339143"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12060"/>
    <dbReference type="HOGENOM" id="CLU_1232437_0_0_1"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24744" checksum="7219536620FB42B6" modified="2015-04-29" version="1" fragment="single">MAALGAKHQLFSLSSGATTAATSINLTTAVLIRQELVVNSLFWILGRCPTWTPLRLRRLAAKVYHLGGVHSGAAIAATLWFAISNVTLFSALSSTSAKENEISIRTITILLDILLVTTIATAFPTFRTWAHDLFEIIHRFLGWIALVLFWILFGFLAHVQLTDGPELTVMDVVGASPAFWSLLLATFSIVLPWLRLRKESVRSEPLSDHALQLHFAGERLPLCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATX1</accession>
    <name>A0A0D2ATX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_11149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230404.1">
        <property type="nucleotide sequence ID" value="XM_016385460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATX1"/>
    <dbReference type="STRING" id="91928.A0A0D2ATX1"/>
    <dbReference type="GeneID" id="27338232"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11149"/>
    <dbReference type="HOGENOM" id="CLU_040908_6_0_1"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="61"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="314" mass="35260" checksum="8EDBBB0F63C68042" modified="2015-04-29" version="1">MRDKARLPPPPPPPPKPKSLTGQRTNSQSQSQSSPSRKSKRGLGWPWDSAASQFKLYTPYYSTGRISWVFNWELWVPESIPPDIEWIPCVRTAANAKDIDAFLTDIIFGRGIKTEALLGFNEPEISDQANLSVGAAVDLWRNVLAAKTKFGLRIGSPGMSSDVSRSVPWLTDFLSRLNGDDGIDFLVVHWYGPRFEDFRTFLEHMHSTFKLPVWVNEFACSTMGNGEASQDEVMAFMDEALPWLDRCEWVERYAYYGHGQHKDVGSWVGRASNFTESAVEEPPSPPPPGTTSTTSTVVSDARRLSRVGRHYCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AU68</accession>
    <name>A0A0D2AU68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230509.1">
        <property type="nucleotide sequence ID" value="XM_016385565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AU68"/>
    <dbReference type="STRING" id="91928.A0A0D2AU68"/>
    <dbReference type="GeneID" id="27338338"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11255"/>
    <dbReference type="HOGENOM" id="CLU_013987_1_1_1"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="644"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW10293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="722" mass="80613" checksum="F3A7ADE471FEF4A2" modified="2015-04-29" version="1">MSAAPRRKLACRVCTRRKVKCDKKIPCDNCVKRGTPAQCERAENDGILARGSSVSAGQHDGGAASLNALQARVAELEALLQMQRGTDSHTVPHSSTPAIEEAIQRTITQTRSSSPSHDSDIEDAVTVLEFLAWGRMKDPDKAMLSPEALRVSEYDDGTGTSPAGDLETALDPDPNLLSWLQIILPSRRQVYQLVEYHNNCLLWFHGSYVAASFSRTLDSFYTEHSGRFDSKGLNLQWVALLFSIMTGTITSAPSSEARSWGFDENEAKILSQKWHKAVITSLNAANFTAHHSLYAVQAIASLTNAAHMLGHSNTQSIMLASVVRIAQSLGLHRLDEDARGSDSELEAGRRAWQELCTQDWFSTAFSESYSINPLHSTSLPPKNCDDNMNVLPDEEPTITSFCKFLAKIAAIMPALQDAMALSSTLYTKHEAVLVHDKKMRSLATGRPCFLAHTALDKSWPCYIPWARRAIAMSSAHKIIMIHRYAAPDITKHYYRIADILARKFLGLSFSNPVFAFTRRTCLAASKTILKEYQASSNDETSPMLWTHQAFSVAACIIICFDILHSRSSSHDEEYLVDQTVEHLQSCRQKSMIAARGVKVLKALQKQIENRGEVRRRLVDSPRDEPPRKRRRGFDAAEFARSFVDLESDSPAEHDTQQRRENSAAATYERPQRTEESPQMDDEDEQVTLPSDLNWLWNMPSHDHDGMQTFNSLLSFANQGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUE4</accession>
    <name>A0A0D2AUE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_11060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230316.1">
        <property type="nucleotide sequence ID" value="XM_016385372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUE4"/>
    <dbReference type="GeneID" id="27338143"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11060"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF240">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="21"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW10100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="413" mass="44694" checksum="EE22853E34355A43" modified="2015-04-29" version="1">MDSFEHAESVSDAYPERGWKAYGVTLGAWFILFPASGLLNSTGIFQAWLLGNDLKMYRESEVAWIFSVFAFLFFFGGFFVGPLFDKFGPKILLPTGTVGVVTAFICGSFCKSYYQYMLALGCLGGGASSILWTSSIATLGHWFQQNRALATGLATTAGGVGGVAFPLLFGRLSQKVGFLWTMRCFALISTLCFVLGLSLLRTRLPRNSQARLVLDWRGFADLRFVLTMMAIFILDWAVLVPPAYITLYATTENLHQISQHILAVLNAASILGRCLPGFIADKVGRFNVMIVCSAMCTLSILGLWLLLGSRMAGLLSFAVIYGFFSGSAYSLTPVCVAQLCRTEEYASRYGTAYGVVSVATLAGVPISGNILRTGNGENYSALIWFCGAAYAASAAVFILARGFGVGWSPAIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AUH2</accession>
    <name>A0A0D2AUH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230594.1">
        <property type="nucleotide sequence ID" value="XM_016385650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AUH2"/>
    <dbReference type="STRING" id="91928.A0A0D2AUH2"/>
    <dbReference type="GeneID" id="27338423"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11340"/>
    <dbReference type="HOGENOM" id="CLU_054079_0_0_1"/>
    <dbReference type="OrthoDB" id="6256716at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="3">
        <location>
            <begin position="122"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="212" mass="24308" checksum="2E362231D02AC465" modified="2015-04-29" version="1">MLQGPSQYLEVYLPSPTTVSFTVTTRRPESSKLRANVRHFLRHTCRIVLVYLAVLANAVKARDVFLLLDSDARRYHLDAILKLCLGSSWIRSLTERSEWWILTPLSLLVVYLCLRRDYVEESLLVLQGLGIQTSTTSRYFFMAPTTTFIPTTQIQDIVIHEAFKGLAVRFYLAVIVEGATEVVVVFPTLLPRREILEEVWRGGRKCLYSGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AV88</accession>
    <name>A0A0D2AV88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribose-phosphate pyrophosphokinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_11597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230849.1">
        <property type="nucleotide sequence ID" value="XM_016385905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AV88"/>
    <dbReference type="STRING" id="91928.A0A0D2AV88"/>
    <dbReference type="GeneID" id="27338680"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11597"/>
    <dbReference type="HOGENOM" id="CLU_033546_0_1_1"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000030">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000047">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW10633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="456" mass="49482" checksum="59D4A9AB666D173C" modified="2015-04-29" version="1">MVRNIVVLGGSSHPALTETICEILGIEQGQALFSKFSVGETRVEIGESVRGKDVYIIQSGGGKVNDHFIELLIAISACKTASAKKVTAVLPLFPYSRQSDVPYNKSGAPLVKAAKLDHKLLQDGNGYSFDSVPPTPHSEKGESYGLLNGHSLQKAASKSQLDGDGDASPAHQARSSHYRDSNSQSKLGSEYFTHSRKRSESNASTSNSIVNRDFAVTPSKSENKAEVPESFKPRPGYRQWVAQAGTLVADLLTCAGADHIITMDLHDPQYQGFFDIPVDNLYGRPLLKKYIQQNIPDYKNGVVVSPDAGGAKRATAIADALGIEFALIHKERRPNKINDRQNATMMLVGDVTGKVAVLIDDLADTSNTITRAAKLLKKEGASKIYALVTHGVLSGDAIDRINASALDKVIVTNTVDQQEHCKRCPKLEVLEVGHVFAEAIRRVHYGESISVLFQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AVX9</accession>
    <name>A0A0D2AVX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230811.1">
        <property type="nucleotide sequence ID" value="XM_016385867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AVX9"/>
    <dbReference type="STRING" id="91928.A0A0D2AVX9"/>
    <dbReference type="GeneID" id="27338642"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11559"/>
    <dbReference type="HOGENOM" id="CLU_560198_0_0_1"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="53488" checksum="C76E1054F980D966" modified="2015-04-29" version="1">MPDPPVTTTGSSRQSFAFISQSSQTGRVDRETQRRVHSHAQANYRRRTSKRQHQGTVELNLAPLQGGSTNAELTLPRHYSSPTTLLDASRTDPFETFALQGGRRAHQLWDHVYDGTCAKFRVLIDIGFIDLVRESTALSQLLSASAWHLVHFLRCEHDTGDDARYSMISNQALQHKLNDIVTGTSDDVVTAVLAAAAYANLSKDPLLFQTHITGLSQILQHRGGEDSLNARPALRLALFWVETNGRFRQDSSPIYPPPYHILVAQTKLTPAFIDVSQLSADRQFGDIQRCTTVRYMFDRLRQLTETVDNESSTKNNFWFESSFLIYTIHPLLHELLSVPRATGHDSTLLQQRECVRLAAVLYVCNIRNRFDPDPGIGMLYGTKLYAMLRSPDLFSSWSENNTSLAALIWILTVAACSAALFDDVRLPFKTLLSTTLRSTGIVTTFPDFYTLIHGLLWSNTVLEPDLGSLENDLAFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYB9</accession>
    <name>A0A0D2AYB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major royal jelly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_11015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231929.1">
        <property type="nucleotide sequence ID" value="XM_016385327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYB9"/>
    <dbReference type="STRING" id="91928.A0A0D2AYB9"/>
    <dbReference type="GeneID" id="27338098"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11015"/>
    <dbReference type="HOGENOM" id="CLU_031076_0_2_1"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238763" description="Major royal jelly protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="44395" checksum="E9DDE50F758E82E3" modified="2015-04-29" version="1">MFLSATTIVVVLCAISGSLAQNLSRDPIGIGPVPELIHLYYDEWPTGIAVSSSGRKFSNYPLGLDATNTKYQVAELTGNSTETAYPNSQINSPPGGAIDYSKFPAQSKGLADHLIGVQSVVVDAKDRLWILDTGRALLPNGTLTTSQYGGPKLVGVDLANNTVFRTILFPPTVSYPDSYPNDVRFDLRASVTGSGQGIAYITDSSSEGRNGIIVVDLGTGESWRHLENIPQVRPKPGFFVTVWGEPVYSNPGNGKPVSRLAFGSDGITLSNDGETLYFSVVSGRHLYAVPTARLRDRSASSELFAQASVVDLGQKGVSDGLESDSNGIVYGGSVETDSVFAFDPANGTVQTYVRDARIEWTDTFSVSGQYLYFTENQLWRGPSQQGGVDRRVKPYALYRVPLLNNGTKIELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZ69</accession>
    <name>A0A0D2AZ69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">PV08_09242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232184.1">
        <property type="nucleotide sequence ID" value="XM_016383561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZ69"/>
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    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW11968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="357" mass="39291" checksum="49DD8FBCFE2F095A" modified="2015-04-29" version="1">MIANPCVDCREHEATLTVRNRRLCSACFTYYVQSKILKRMASYGFKSLSSEKERRLFLPLSGGLSSLVLLQVLDVQLQKQIANRNKTSYDIIVARVVLPGEKNSGSIQRDYEALAETFASHTFLPLLSLHQILQLDCDVERDLRHLGIVRHGGESDQDFFIRIVGCSTSASAASDLQSILLKRLLVAAARDQHCDNVLWGHSDTRLAALVLADVAKGRGGSVSSSIADGQTLQGIDFNYPVRDLFKAELQTYARVSSEPALKTTVEQDTQVQQPTSIRNTAIDDLLNTYITSQGEKYPSIMANVVRTASKLEAKRPADNTIVACPVCLLPRVGTQGSLATNSGLCYGCQRMRQDIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZX0</accession>
    <name>A0A0D2AZX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232494.1">
        <property type="nucleotide sequence ID" value="XM_016383871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZX0"/>
    <dbReference type="GeneID" id="27336638"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09555"/>
    <dbReference type="HOGENOM" id="CLU_2922639_0_0_1"/>
    <dbReference type="OrthoDB" id="4116718at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW12278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="61" mass="7035" checksum="EBB5B63F59A85F28" modified="2015-04-29" version="1">MEKNGCKTASTPEDVTLEFYRLRKPIGAASIFEYINPETHEHVYEPSRHFTKSFTWGGDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B048</accession>
    <name>A0A0D2B048_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_09620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232559.1">
        <property type="nucleotide sequence ID" value="XM_016383936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B048"/>
    <dbReference type="GeneID" id="27336703"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09620"/>
    <dbReference type="HOGENOM" id="CLU_773948_0_0_1"/>
    <dbReference type="OrthoDB" id="5426355at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238737" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW12343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39581" checksum="A4C995C071B277CF" modified="2015-04-29" version="1">MREAPRIALLAISTFFGLSVTQSIVPTSGSGTFPACAVNCAVLLQAQSTCTPPNVATTNDLTYENCFCQSSLLAALYSTPDSICTAECTAESDRSELQTWFQGFCSEVGKGIDPLATTSTQTPTSTIVVTITSTSTPSPTSTGTGSVGGGTSGSNKSWIDTHWRWILMIAILIVGFALLAWLLVWLKRRHRRKVESQRVAMSGLPVVSEKDSTRGPTPDLWGPHQHMHHTQGFEYPVASTMGSGALNASDDRRDNRHSKRGSSSQPKRQGRSEMTDVAGRPSASRRRSSKGKARARDSTAEIGPEQISPVERDRSTSHRRRDRDRDRGRERSMESASDINHQQRLREVRGARRQKDHDDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B0A3</accession>
    <name>A0A0D2B0A3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_09405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232346.1">
        <property type="nucleotide sequence ID" value="XM_016383723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B0A3"/>
    <dbReference type="STRING" id="91928.A0A0D2B0A3"/>
    <dbReference type="GeneID" id="27336488"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09405"/>
    <dbReference type="HOGENOM" id="CLU_074889_0_0_1"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="187" mass="22041" checksum="C3DF0C8286988D18" modified="2015-04-29" version="1">MDVPEPDTTPFDAITVQSNKLQRQYQTYLDKSTPYVTYRWSATGALLVLFFLRIIIAQGWYIVAYCLGIYLLNLFLAFLQPKFDPSLSQDEGLEDGEGSGLPTKQDDEFRPFIRRLPEFKFWHAATRAVTISFLCSWFEIFNLPVFWPVLVMYWLILFLLTMRRQIQHMIKYRYVPFSFGKAKYSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B111</accession>
    <name>A0A0D2B111_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="14">PAGM</shortName>
            <ecNumber evidence="4 14">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PV08_09856</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232794.1">
        <property type="nucleotide sequence ID" value="XM_016384171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B111"/>
    <dbReference type="STRING" id="91928.A0A0D2B111"/>
    <dbReference type="GeneID" id="27336939"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09856"/>
    <dbReference type="HOGENOM" id="CLU_022890_1_0_1"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="68"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="141"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="21">
        <location>
            <begin position="210"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="330"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="18">
        <location>
            <begin position="499"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="17">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="405"/>
            <end position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="530"/>
            <end position="534"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KIW12578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="566" mass="62459" checksum="8FC8EAA98D3F0D0E" modified="2015-04-29" version="1">MSSYNPRESVFNQPKPIVHLPHALLQSITKAVQPYPIPEGKKYEYGTAGFRMKANAGLDHVMFTVGLTAAARSKKRNATIGIMITASHNPAEDNGVKLVDPMGDMLEQSWEQYATTLANTPNDSLATAYEVLVNETLVDEIRQLHERPAKVVFARDTRASGPYLVNALKAALDAVKVEYTDYGILTTPQLHYIVRCVNTLNTPYAFGEPTEQGYYEKMANAFKTLMYGRAIQGSVTVDCANGVGGPKLKELIKYLPSAKEGGIDIKVVNDDVVRPEALNFECGADYVKTKQRAPPSSNAQPGDRCCSLDGDADRIVYYYTDEQKTFHLLDGDRIATLGAVFLADMTRVAGIDNKVKIGLVQTAYANGAATEYVEKVLKLPVTITPTGVKHLHHAAARYDIGVYFEANGHGTVLFSDNAIKIIKESEPKSPGQKHALDSLRACVDLINQTVGDAISDMLFAEVVLAHKTWTLENWRNTYIDLPNRLVRIEVRDRSMFKTTDAERKLESPKGAQEEIDKLCQMYVKGRAFARASGTEDAVRVYAEAHSKTEADKLAQQVSEVVRKYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B483</accession>
    <name>A0A0D2B483_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromosome transmission fidelity protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233994.1">
        <property type="nucleotide sequence ID" value="XM_016383291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B483"/>
    <dbReference type="STRING" id="91928.A0A0D2B483"/>
    <dbReference type="GeneID" id="27336052"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08969"/>
    <dbReference type="HOGENOM" id="CLU_053544_1_0_1"/>
    <dbReference type="OrthoDB" id="5329385at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031342">
        <property type="entry name" value="Mug163-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17119">
        <property type="entry name" value="MMU163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40193" checksum="077AD420760088B1" modified="2015-04-29" version="1">MTSKVMRKLPKATTRSSVSSWTGRPSSPSPGRCRHKSTSAGNSAPRQILPRRYLAQVRPEPLSELWFTASSPRFGPADELLGPPTPGKDCDHQPPDERLLKLGKSNTLLNHILQGEKLTTVIALRRLSPLLPDILTKPLPQEILSPDVTLHLFPSTHPHLPAVKGKVAYRAALWTCPVAWGCVPIVGNVKLKIISEKIVRTGYTYAIPQSDDEPADLSAEKLVVRWQTEPKQNGQTSTASHFSASSSAAQANEVSHGGINRGLSKLLGGDKPIFNLSNDDEFSGLFIFTFDSEGRIASHTIEHADEDSSFDKTSKVVTLTDWLLGKARWNRAKEKEEELVPGLAMRVCREEWDLGRRLGQGNGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4B9</accession>
    <name>A0A0D2B4B9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_09000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234024.1">
        <property type="nucleotide sequence ID" value="XM_016383321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4B9"/>
    <dbReference type="GeneID" id="27336083"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09000"/>
    <dbReference type="HOGENOM" id="CLU_885765_0_0_1"/>
    <dbReference type="OrthoDB" id="4153848at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="323" mass="36129" checksum="FCEA28815266CA56" modified="2015-04-29" version="1">MTEFGPPPANPERPRPDSQALAFQPMIDEVSTLETLTDTEVSTSGSLTDADSTLDTFNDTRVEFIDEEPQDFNQLAFEFPLYLDDQRLTSLSLFTSFSSRRDEVIAELGGLDNSHFLERIAAIVALSLCEGIPSFLKDWSESLEAEELISQLHAELHSDSSQVHAELEGEKTVNHTRNLLLLVAGYVIQSHFQPREHLVSKLELPSRLSSDGSTQYKIATLCYARHFHCMPALSVLAPSLSLESVSRRELQAFQDYALQHFPLKLSYDNPPAYESSTLPGLTPALTYGEETSEFEDNDSGTWLSSIMNPFMRCLPFRRQSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4I5</accession>
    <name>A0A0D2B4I5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_08779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233806.1">
        <property type="nucleotide sequence ID" value="XM_016383103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4I5"/>
    <dbReference type="GeneID" id="27335862"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08779"/>
    <dbReference type="HOGENOM" id="CLU_006909_5_2_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW13590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="53658" checksum="502CBCCB95058BC8" modified="2015-04-29" version="1">MGGTITCPRVAVIGAGASGVAAAAHLLVEGIDVVVFEKARVTGGVWVFDPRRPPDPPYPNLKASACYESLRTNAPTPLIEMSLNSWSPDTELYARHSVVVDYIRQTAAKTGVDKTILHNTKVDSVTKDQETWRVRTSTWDTTAEVVSQEWGFDAVVVATGHYHAPYIPDIPGLAQWKEAWPDRVQHSKGYRSNKEFQDQVPVVWIAQWPKNDTEHCLQVVLLVGAGASAVDIASELGPCAKKIWQSTRGSTTDHPLEMLPVNATRVAEIASFGPLHSEAASSAGPIPGKITLVDGQILEGIDKVVMCTGYLFSLPFLARHHNDNLSAGEAGPDVLVTDGSQIHNLHEDIFYVPDPTLAFVGVPTDVASFSLFEFQAIAIAAVFSGQTMLPSEEDMRTQYDERVKDRGTGKRFHSLLKKDVAYAAELMEWVNRGRPPTKRKSNGYSKEWLDRRATFIQRYKGKGGHLKADSTRLRIKDTWMEETGGKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B7I0</accession>
    <name>A0A0D2B7I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nitrite reductase [NAD(P)H]</fullName>
            <ecNumber evidence="19">1.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PV08_07419</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NH4(+) + 3 NAD(+) + 2 H2O = nitrite + 3 NADH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NH4(+) + 3 NADP(+) + 2 H2O = nitrite + 3 NADPH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="19"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234851.1">
        <property type="nucleotide sequence ID" value="XM_016381749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B7I0"/>
    <dbReference type="STRING" id="91928.A0A0D2B7I0"/>
    <dbReference type="GeneID" id="27334502"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07419"/>
    <dbReference type="HOGENOM" id="CLU_003291_0_0_1"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015980">
        <property type="term" value="P:energy derivation by oxidation of organic compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19943">
        <property type="entry name" value="NirB_Fer2_BFD-like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19944">
        <property type="entry name" value="NirB_Fer2_BFD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1100:FF:000002">
        <property type="entry name" value="Nitrite reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="22">
        <location>
            <begin position="923"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KIW14635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1121" mass="123642" checksum="530FEB823893755C" modified="2015-04-29" version="1">MANNQTPERSEDAPNGGPRKRIVVVGLGMVGIAFVEKLLKLDAKRHEYDVVVIGEEPHLAYNRVGLTSFFQHRQVESLYLNPETWYKNHPKESFNYHLNTLVTEIRREERTVITAKGDEIPYDILVLATGSDALLPRHTPGHDAKGVFVYRTIDDLQKLISFSSTVKGTTGCVVGGGLLGLEAAKAMMDLEEFDKVKLIERNRWVLSRQLDADAGTMVVELVRKLGLDVMLSKRVGKILTDADNAVKGIVFEDGEQIDCSCVMFAIGIKARDELARKAGLKCADRGGGITIDNDLRTSDPNIYAIGECASWENQTFGLIAPGVEQADVLSFNLTQAKSHSPRTFKKPDLSTKLKLLGVEVASFGDFFADRDGPKDLPKRHVKREERKASESQAGQAQDKVKDLTTGPPPPAVKALTYRDPFAAVYKKYLFTLDGKYLLGGMMIGDTKDYVKLVPMVKNKKALDVPPSQFIIGASKDGDEGGDDLTDDTQICSCHNVTKGDVVQSVKDGCKALGEVKTCTKAGTGCGGCMPLVTSIFNKAMKDMGNEVSNNICPHFAYSRADLYNIIYVRKLQDFGSVMREAGKDPESLGCEVCKPAVGSILASMFNKHIMDKPLRGLQDTNDRYLGNIQRNGTFSVIPRVAGGEISPEKLIVIGQVAKKYNLYTKITGGQRIDMFGAKKQDLLDIWSELVAGGLESGHAYAKSLRTVKSCVGTTWCRFGIGDSVGMAIRLEERYKSIRAPHKIKGGVSGCVRECAEAQNKDFGLIATEKGFNIFVGGNGGATPRHSETLAKDVPPDDVIPILDRYLMFYMRTADKLQRTARWVEQLPGGIKYLREVVLEDKLGICAELEKQMQELVGTFFCEWTETLNDPEKRRAFQQFANSDETREPAVEKVEERGQVRPAYWPRDSVHDDFKGTKWSSLTWQPIVEARKFQDLDTGSSQTVIRGDTQLAVFKLKGKYYASQQMCPHKRTFGLSDGLIGETTAAAAPDCKEDSKLYVSCPYHKRNFQLNGAVNFDKPDAGAGSCSNDTSMSIATFQAEERGDGWVYLKLPPVEEMDAVLGTSKWVVKSQEAQDPFESLDKKLGLHKGLRPSRTVGAMPGTGNVMAARRTVGVAAQRRIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAF2</accession>
    <name>A0A0D2BAF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235751.1">
        <property type="nucleotide sequence ID" value="XM_016379924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAF2"/>
    <dbReference type="STRING" id="91928.A0A0D2BAF2"/>
    <dbReference type="GeneID" id="27332666"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05583"/>
    <dbReference type="HOGENOM" id="CLU_010194_48_0_1"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="475" mass="50670" checksum="DEB21CF7D7031BD4" modified="2015-04-29" version="1">MDALLRTTSRDQSQPFTIAPSSPSTQRSPAFSSDSTFKIALPSTTDPPSATNPPKQKVWVIFGATGHMGRSVTKTALAHGDLVCAVGQSLQDSPSTLSTLLSVLSNASSTNYADTYLGLLCDVRIRASVSSTLDKTIAHFGRIDIIANCTGYGVIGACEDQDEHEIRNQFETNFMGTLNIIQLSLPHFRKRQAGRYLIFSSTSGALGVPGLGPYCATKYAVEGLIESMLYEVDPFGIRATLVEPGHLRRDDGGVGSSTAASTGAQGAVGVPTTNGSGAGVSRPGTAAAGSAGAGNSVNTLPLFGHFKVAKASEPYTGRDAPAAHAQRTLHWIGNNQPVSVVKAAELVWQLGHCRYPPLRLILGTFAVESIRDRLKSIIEEIEDWKHLSFPPLEPEPDADGEVDGEGEGEDDADEQGDGDEMDRDGGDDDNDDDNTDGGDRCDDRKRAETKPQQRGATNYEGTPEVKMEDRMDVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BAU3</accession>
    <name>A0A0D2BAU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236294.1">
        <property type="nucleotide sequence ID" value="XM_016380467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BAU3"/>
    <dbReference type="STRING" id="91928.A0A0D2BAU3"/>
    <dbReference type="GeneID" id="27333212"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06129"/>
    <dbReference type="HOGENOM" id="CLU_030671_1_1_1"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF8">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW16078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55428" checksum="7E06D95D9B242D09" modified="2015-04-29" version="1">MKSHSHHVDGDGNHHKGDGAGNDESAVEIHPMHLLPFDSLPNKKQVWPCRPGSRGEGLGRLVLLTPDVVAAAAARCIRTGRRVSLGWELTKLEIANFGRSPCDHRIVPLLDGVAFDDIYTFNPQQSSQWDGLRHFSQPVVVVTPPGSGSGSAEETGLEEKEDRVLKEDAEGDGEVEVEVKVEDKGKKSTGSKRLFYGGVTPSEIISTASDRIGIQHWAKQGICGRGVLLDYVRYAERRGITYSTFSDHAIPLSAMLEMAAEQDNLTFRRGDILFVRVGVTREWDTVMTRGDKIAYANSPNPQHAGVEGTEEMARWIWDQGFAAVASDAISFEVYPPKESHVRRCCRPPGEDEAVVEVKAGAEVEAEAGAVNENGNVNGDTKNTNGTEDTHRDIADRKSTEHDDDCNGDHDHDDDGGHGVEEKKKKKKQKQKQEQKDAVGHTSVVPGIFLHEYLLAGWGMPIGELFDLEGLSRLCEQHRRWEFFVASSPLNMPGGVSSPPNCVAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BC21</accession>
    <name>A0A0D2BC21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_06226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236391.1">
        <property type="nucleotide sequence ID" value="XM_016380564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BC21"/>
    <dbReference type="STRING" id="91928.A0A0D2BC21"/>
    <dbReference type="GeneID" id="27333309"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06226"/>
    <dbReference type="HOGENOM" id="CLU_300902_0_0_1"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="1">
        <location>
            <begin position="15"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="994" mass="112619" checksum="E88CA2EEB5736DF0" modified="2015-04-29" version="1">MASTQLPQHMSLAYKRYKRDTEAVATWLAEKAFKLGFVASASAPSPKQPKLRGRARKLARDAAKLSPSTAANGPKYTYTVKTTDFIQMATKIVSARPRITLSRSLETIWRRAIQARLDFSAWFRSRSSVDPLADEKHAHFTTVLEKALELLQPCCELPDAQEFPQESKEEVAETPLEQMNNMFQHLEVEDISSDDEEPAAEKSTMKSKTPAPARAYIEFKEEEAEAEFFFAIWSFLQDVTAVRVYVACTWQLYSTGVIELMQCASVTNFAVDLVRRAEADFEASLQRPRNYPASEFPTGSLPFLIFKLHLDKENGGPLDFDPDLPSTIVICGCEICDMLLYVPWAMAKAYVDVLVECPPTLPTSNNAFAVDVPGLPPAKTHRAEFYHAKNPSQKAVDELHEILPTSCMLSLMFKNAFVEDEILHASRHLIENHTVPVWVSFAFQVQLDMQRLNTMKPIPAFRELAESYGDIKSRFKRHRAWVKSLEHAVWDLDGSARSLVKDFGDWIEGSKVGRADPTEFNLRLAAGQDRASAMRDTKRIPLLELFPLTCATLKTELYLEWHILGLKLVNYTGHVPMLCHLYNALRKLNPDAPIWPDLELVIRNQDPARVFIGGIPSTPEDFLKRFFLAMGMSSSMLARNNNAGFSKSNARKHQFQEAPIAGNLFARWLGSETRKVDEVAYQLQKVLSDPKYKDDLAHRLFIPVQDRSDELKMTLLNTEMVRVLISFSEGFAAEMPAFMFDYFAMERRCYDFYLRLRDAYRKNMDKYETLQSKEEEKINSPVSITIAILTLARDGEAIAHNMRSRRAQNKAQGPAIAKLMKASLIGYTDEKTSDFIEDLIDLTRKNGAAELIQQYMDISEHALARNTFHPMLATLQNFLEENKSDREIRNLKTKVGDSDYGIFLFCRASLEALYSSQHPEAWADLLVPDDKLYDALKCSAANPILVMLAILNLRQKKVMCGTGEDSHSARLLEEISPAELAEYAKTQGQKAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BCW5</accession>
    <name>A0A0D2BCW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237024.1">
        <property type="nucleotide sequence ID" value="XM_016378347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BCW5"/>
    <dbReference type="GeneID" id="27331081"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03998"/>
    <dbReference type="HOGENOM" id="CLU_1170651_0_0_1"/>
    <dbReference type="OrthoDB" id="4146887at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="237" mass="26516" checksum="A32580516D7B2C86" modified="2015-04-29" version="1">MPTFSISKHGISREVLETDLPLYLGRDARVVNTHDSDRYVIEASLSPPSTMIPSLRDDSARWYESNGYRRRNSYAESSVHRERRQSFSQDSGGSHRYSAARRDSNVSRSGTSYAIPAIAIPQRPNMMPRYSSNSSSVMESVSGSPSSTFGSPPSRSGRSYSYSTNYTSSRRPSDAMASLDEHVLNRADSSSSESSDYGIDGILGFEKRDARDARRRDGHGSGRRDHHRSSRSHHDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BD70</accession>
    <name>A0A0D2BD70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236746.1">
        <property type="nucleotide sequence ID" value="XM_016380919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BD70"/>
    <dbReference type="STRING" id="91928.A0A0D2BD70"/>
    <dbReference type="GeneID" id="27333668"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06585"/>
    <dbReference type="HOGENOM" id="CLU_012023_0_0_1"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="40"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW16530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="911" mass="100806" checksum="06D9D7960B7E9A97" modified="2015-04-29" version="1">MAEVVRLVASANARGPTSGFTDADDDAVQLPLDYDRQGSKIFLPLRVGAFTLQHRIVHAALGRSRSIYGQESPLAVKYFEQRATPGGLIISQATGGKPEWSAWPFSASIHSESQIKAVRQITEAVHKKGGIWFQQLTHVGRCTSPALVKLAWERAGHSKPPDYGYKAFAPSAIGESGVCTHSGEPFGVPHSVSLEQIKEIREDFQNSARNAVRAGADGIEILSGNGFLLDQFLHDNINQRTDQYGGSVENRSRFTLEIVDDIAQIVGHQKIGVRLSPFSNFHETDGSQPLAQILHLARELALRGVAYIHVGEARVSRNLGIEENLQRLAHKGIPPEDISLRPFHKLLQETRPTNPSDAPTVLFGAGGYTSATAILTVDGDLADAVVFGRRFISNPDLVNRLRLGVPLTPYDRDTFYTHGSKGYITYKTYSEGNIDEDVDSTTNDTSYGTTSSVNGHHKPKTVAIIGAGVSGIVSASAFQRLGDEFEIHVFERKSDPGGSWAYDPISNVIPIFPASDPDVINPPLPRPKAKLPVTTARNKQQRFTSSPLYESLYANIPYNVMSENSSIKLPNPKLESAPYCSADQISEAVVTAALRFEKLIRYNTTVEAVEKIENKRLRLTLRTENPNDTDTWYEEEFDFLIVATGHNSVPHVPAIPGLNTWKGQLSHTTTWRSGKDFSGKRILVVGSNESAIDVTLQSLPYVQWPIYVSQRTPHPRFPTVFTRKGVEVLPTIECIEGGTIHFSGGQALTSIDTIVFATGYFYTYPFLKHVRPSVPGGQRVPGLYQHVFDMYNPNIAFIGVANGSLSWLTWEKSAFLSALLWSGRIKLPPIEEQKKWEARRLAETTSKEKMFHILAKPSERVIYFDELNELAADYLHTDAPDDELLRSFPWDWIVSLGTGAARKAQYYGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BDT7</accession>
    <name>A0A0D2BDT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calcium/proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_04304</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237329.1">
        <property type="nucleotide sequence ID" value="XM_016378652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BDT7"/>
    <dbReference type="STRING" id="91928.A0A0D2BDT7"/>
    <dbReference type="GeneID" id="27331387"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04304"/>
    <dbReference type="HOGENOM" id="CLU_001583_0_0_1"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000017">
        <property type="entry name" value="Calcium permease family membrane transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="927"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="960"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="995"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1034"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1065"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="11">
        <location>
            <begin position="239"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="511"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="926"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="768"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="861"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1112" mass="122651" checksum="50DDE166E7DC867C" modified="2015-04-29" version="1">MSSSETPGRSPAKSPVLRFVPDVQAEATAGEVASGTIRRDYGTLGSVQASASQRPPGPRVDDVSDLPPLSPQLSRPKKPPTMRRTSTRTGKLLPHRGEQFSVDDDPSEVEEANSMQPGPSASRQQSTVRRRTHPATLTRVDSAEEEAEETAPEQPTEADAEEPLDDTEAGDLGDNEEEELSDAESFTLRDRQLAINQTHPFGIRIWKPALYKKGRSVEKAAEEDIHSSPSQIVSPWLWFFNCLWTVFFGWWLAVSAAIAAFACYLFAFDPSAAAYGRVFLGLSNYLFWPFGKFVKLVQDENYVEEDEGEGRSISEYERWQSGDLEYGRLMFGPTFTHSGSIVGRHRNSIDSASETDSLLARSGRTDRQDTTLSNKKRRLFGRGQWTLGRVIFFVFYYFFVAPLLLFASGICWFMVFWIPMGRVTLILFSNLRKRPLSMTFHRDVSAARSSTKPSSILLCTYRAVGKRYWKYTIDGTNIFLINFLAVVVFVILDYFVLKVALGVNFWLTSPALTFTLALISIIPLAYFIGQAVASISAQSSMGMGAAVNAFFSTVVEVYLYCIALNEGKAALVEGSIIGSIFAGILLLPGLSMCFGAIKRKTQRFNVKSAGATSTMLLFATIAAFCPTLFYKIYGSHEIICRSCTTDDSNPNDCRQCYFRQLPAITDEFYVKAVRPYCWMAAIFLFSSYIIGLLFTLRTHAAIIWSTDLEEKKPSPAGQVPTDISPLDTRNQSVANSQFLNNPNGYVPKTAIRESQLYKRILGQSLRSAGLSAESDTQNERERPVTPKSVLHAHDGDQSDLPHLVPPKSSHGTESLPSPEILPFVPSLSEEENNYLVRQVAEIAATAATVAARDAVNHPRTAAYQASHASRSDTVKTQRPSNGRKTTMADQDAFTTPATEHAVPHEVSEQSGQGGHDAPNWSRTKSSVILLTATVAYAIVAEILVDTVDVVLESVDIDEKFLGITLFALVPNTTEFLNAISFAMNGNIALSMEIGSAYALQVCLLQLPALVLFSAVQGQWIDAGELIDHTFNLIFPQWDMVTVILCVFLLSYMSGEGKSNYFKGSILVMTYLVVVMGYYFSGFTTLTIMETSAWQSGTPGPMGVSSVRPGREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEI7</accession>
    <name>A0A0D2BEI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="8">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="8">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PRT1</name>
        <name evidence="12" type="ORF">PV08_04592</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237614.1">
        <property type="nucleotide sequence ID" value="XM_016378937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEI7"/>
    <dbReference type="STRING" id="91928.A0A0D2BEI7"/>
    <dbReference type="GeneID" id="27331675"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04592"/>
    <dbReference type="HOGENOM" id="CLU_011152_4_0_1"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000419">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000235">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="644"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="743" mass="85070" checksum="5B1586EA0CD758FB" modified="2015-04-29" version="1">MAPGFDQLSDHDFEDDIDDIDFSDLKERYDVRMEEGLDTFVVIDGLPIVNNDQKAKLVKFLLKRLNTVGRIKDGEESVFMPMNDQGVSEGFAFVEYQTPEQAIAATKQLHGVALDKKHTLAVNKLTDIEKYGREGRIDEQYVPPEVEPFSEKEHLRSWLFDPAARDQFAMFRGDKVGVFWNNKKEPPEMVVDRMHWTQLFVSWSPQGTYLASVHQQGVQLWGGPSFKRIRQFPHPFVSLIEFSPGEKYITTWSHQPIVVEEGKGPLTIDEEGKHIIIWDIETGKPLRSFTAYDLTPPPGTDPSAVPPKAKVQWPAFKWSADEKYVARMKPHESISIYELPRMNLLDKTSVKAEGIVDFEWAPAITQREGVKTYESLLCYWTPEMGSNPAKVALMSVPSKEIVRTRNLFNVTDAKLHWQSEAKFICVKVDRHSKSKKSLATNLEIFRIKEKGVPVEVVDSLKDTVINFAWEPKGDRFVLITAGEAVAGSNVLPKTAVSFFAPEKIKGPGTGAFKLVRTIDKKNSNGIYWSPKGRFVVVATVSVQQHSDMDFYDLDYEGEKPESEANVAANLMLMNSEDHYGMTDVDWDPTGRYVTTSASVWTHQMENGYKMWTFSGQLLTEAPTEKFKQLLWRPRPPTILSKEEQRTIRRNLREYSKEFDELDKELEEGANLAVVEARRRLYMEWYSWVAQEKELLKEEREELGLPDPESELQLQRTKSLEADGEKVVEEVVEEVIEETEEIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BEK8</accession>
    <name>A0A0D2BEK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237634.1">
        <property type="nucleotide sequence ID" value="XM_016378957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BEK8"/>
    <dbReference type="STRING" id="91928.A0A0D2BEK8"/>
    <dbReference type="GeneID" id="27331695"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04612"/>
    <dbReference type="HOGENOM" id="CLU_069253_1_0_1"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF13">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="226" mass="25080" checksum="2072017560A410BD" modified="2015-04-29" version="1">MGKPEGGKLKIYIDCVSPYSWFGFTNIIKYRPLLNAHGVSVDIIPFFLGGARDGVGNPWTPTPKAKEAFSAQDSKLTGELLGLDVVTPEVFPILSLFPVRVATYVKDHYPPEKFEATFPAFSSAYWSKGINISTPEGIIQALKGIFPEDEIKDIMKKALSPENKKRVVDVTMGSGAFGAPWISAVNSKGERRDWFGNDRWDQVFYHLQVPYTPVSIIPPEEAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BF52</accession>
    <name>A0A0D2BF52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal eL28/Mak16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_04446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237471.1">
        <property type="nucleotide sequence ID" value="XM_016378794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BF52"/>
    <dbReference type="STRING" id="91928.A0A0D2BF52"/>
    <dbReference type="GeneID" id="27331529"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04446"/>
    <dbReference type="HOGENOM" id="CLU_106801_0_0_1"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000002">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW17255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="152" mass="16619" checksum="4AAD1881BE563E53" modified="2015-04-29" version="1">MSEVSNVSGDLIWEIVRGNNAYLVKRKTAGGVQFSRDPFNLTNKHSRTHEGFVNDKAVSVQANDKGGVTLLTKKPGKSNTPKTAYNTHAYGKTTSNRKIFKNIADAVGKRSYRGDLNQAAISRASNIKYSQAPKKDTPAAKPRGLKARKQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFB9</accession>
    <name>A0A0D2BFB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237909.1">
        <property type="nucleotide sequence ID" value="XM_016379232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFB9"/>
    <dbReference type="STRING" id="91928.A0A0D2BFB9"/>
    <dbReference type="GeneID" id="27331971"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04888"/>
    <dbReference type="HOGENOM" id="CLU_022339_1_0_1"/>
    <dbReference type="OrthoDB" id="5281682at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="619" mass="69876" checksum="3B29060336B9DA62" modified="2015-04-29" version="1">MLVQEMVLDNDSNQSRDIYGRHFVPMSKNARSDVSFPLAPPRTRAPSMASTVDLGEKDGQSMGVFTIRATDSPVPETMRHERERDNRVPDKTGEPRPSLQNLPLEVQGKILDFIFGDMHSVYAGSTSLRGKSVSSLMRHPRRKAVSDFALVSPTWRELVQERIYRHIKIKGTRAGLDETQEFFLEHMHLTKYVRHIEFWVPVWGDKASLDDHIYNPLNPLGTDRNTNLHLANHVHENLLPVNDFIGYSFKLCAASATLSQMFSLVNCFFSNARVFTLEGGHCKKSNMIRHFPQTLFPDPNQRLEELHNIRTFAMRGAWNIMRSYSHWKTIEAALPNVEEWHCGYAKPRSEADSTIDAILINLPPQYRHVNISLDGMYSKDPTTLGSSHHHGQSHLCERLGNVLPQLESLSYTGKVCDCLWSSAFSALSQSKAEPRLKALEIVVKSCCRQRVTDTDLETGETIYHEAGGAGITNLIFIRSFERLVMKTVEALPLFPQLNYVRIRFIDLDSPCTLLNPYWQLENGKVSGIWNEQIVERLAELRPDIGYIELSDGIEPAGWHKRPNLPTVTGTGGRHFQDVPTSPLSVTDAVVGNGCSLYPKTKPKSIKTSSYKLVAESRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFK2</accession>
    <name>A0A0D2BFK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230355.1">
        <property type="nucleotide sequence ID" value="XM_016385411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BFK2"/>
    <dbReference type="GeneID" id="27338183"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11100"/>
    <dbReference type="HOGENOM" id="CLU_028818_2_1_1"/>
    <dbReference type="OrthoDB" id="5086080at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="55252" checksum="3B1D96AC7779A410" modified="2015-04-29" version="1">MTLPARKKARVDSGSSGASADAASALQSTAMERRLKKRESDRKCQRISRERTKSRIAQLEKLVEELSQADDSGKVAALLETVSQLQQERDNLANKLKSIESILFPGEPPTKVKVPKVEGSPSSNLNLSSLAAEPEHDAEVVSTATEVPEGSAQGISGPVVNPKHITGTAEDSQRMVLQERSLRNDQYMPLLAPIGGFVCECSYARSLQKQTLNFWYQGNMTLGAWMKWPKLVPAVSDDDPFHDDTPVRAIIEGWDAVEQRGHVHPMWRLLRTMDEGLFSHAETATSRLGILGNVSRVLRAHLDTTHKQLKQLPTYWPSRVTAEHCAYATNFVAWPGVRQALDRDEHRFCSNHFWTVFINSMRVEWPYEFRDCYLLNSATGLYKLSPLFDETIKDIRKIGVCKSFFQHYPELEGAVNVIYENPSHVECVTAARCAQVDVNGLDLGLKVAKARGPSTGIVATGQKPSTALASGLFDQQASWDLLDAIPELSLIPNRDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BH05</accession>
    <name>A0A0D2BH05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_05100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238121.1">
        <property type="nucleotide sequence ID" value="XM_016379444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BH05"/>
    <dbReference type="GeneID" id="27332183"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05100"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="9"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW17905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="506" mass="55528" checksum="F1503514EE8CA5EE" modified="2015-04-29" version="1">MISLVQFGIVLFVALGSITYGYGSSIIATTTGQPTFLSYFELDTRSNSDELLGAINGLFSAGGLFGCISCFWIPDKWGRKKAILFASFVSIVGNGLAAGSVHIAMFMIARLLTGFSVGALVSLIPLYQSEISPSRIRGLLVGMHGTGIAFGYVAASWIGFGFYFVNASGTQWRMPLAIGGLWPLLLATGVVFIPESPRWLLVKSRPEEALKAFKACRTESGPHNNEHAIHEEFQLLHSQVLEELKDHVPLKEFFTRPALRKRCWIGWLTMVAGQCTGTIVINNYGPFLYRNLGFSVVNQLLIQCGWITVCLFGNAFNATVIDYFGRVRMLLFGFTGDVIALAGECASVSVYQRTGSTAAAKAAVFFLFLHIGFYGWTIDASTYIYATEIFPNPLRARGIGISCSGAAPTAFNNIGWKYYLVFTILTAICVVIIWFFFPETKGLALEDVAEIFGDGIVLTDTREEQIHQQFKQSHYHAEVLEEIADVPPVHVSEKSEGGKPKAEHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BHM6</accession>
    <name>A0A0D2BHM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10173</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231090.1">
        <property type="nucleotide sequence ID" value="XM_016384488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BHM6"/>
    <dbReference type="STRING" id="91928.A0A0D2BHM6"/>
    <dbReference type="GeneID" id="27337256"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10173"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_1"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="212"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW10874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="594" mass="67087" checksum="613F4DDF750A4155" modified="2015-04-29" version="1">MRAAKLLRKSHLQLCPRISPVQVESGMLWRFEKSPCISRSLRCLQRHSLEPKAIRHSFHHTRPVRAEKNDGTSSALRAVRHATLVDSSRLYDAASRNAIVKVVGLVRSVRKQKNVAFARVADGSTLGSVQAVFPHPNIAKDITNGAYVSLIGKWVASQGAGQSHELLVHEIETIGESNPLENPIQKQSMTAEFLRTVPHLRMRTAFQSLLVRVRSQLTAAVSAHFNNRSEPVYQVHPPLITSSDCEGAGEVFTITPRSKELPRFIPPSKSKEQEKLYFREPKYLTVSSQLHLEAYSAQLGDVFALSPTFRAEESDTPRHLAEFYMLEAEHRHIAFDDLLASVRSLIVDLTQSLQAHKTGKELLQYYEDHKHRPDDVDFVDLEERWSRLTGPWHTVTYTAAIDALEKAHEASSRTLFVNRPQWEWGLQLEHERWIVENIAEGKPVFVTHYPKAIKPFYMLPSAVISSSGQHSAPADNYTEHQETVACFDLLLPYGYCEVVGGSLREHRLKELIHNMRSKGLIKNAEEAINRTDYPFLEPGESLGALKWYADLRRFGSNPHGGYGLGFDRLLAYLTGVANVRDVVGFPRTWGRADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ22</accession>
    <name>A0A0D2BJ22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231565.1">
        <property type="nucleotide sequence ID" value="XM_016384963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ22"/>
    <dbReference type="GeneID" id="27337732"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10649"/>
    <dbReference type="HOGENOM" id="CLU_024696_0_0_1"/>
    <dbReference type="OrthoDB" id="3557758at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="496" mass="55077" checksum="E26BAD5D2E400214" modified="2015-04-29" version="1">MTDEEVEMMRQGQMEAAVNRVRLKERSRDGRDSGRFYQYLTVETNETTPSLTLPIQLGASDTLRKDLDRTGTDNHHHPIDPTLANNKKCVDHHPSSVTTTTSDTRSNQSGPVLERLQQRHYDHGAKSSQYWSGRYLSVCDRIRSEPLKNNKLLPPVESSTQAMDMVFDACEKARIRLALDELRRSCMTHDALESFEHFETGLLKKIGTSHHSLYRESNSLSRVSDTGSILRTTGGGGRKSGDALNVPNLLWTPSTPNRWLSSINAEAAMSISSGSFEGKGALAKSKTTGNLASFIPKFSSRQLPPYIKTNHQSNSTAPNAHQRRVSYIGLSPESAGSTAGDREPPSASQNRSTHRRSGSQMSSPGLVNSESRSPESQSTLTTTTMVEKDRSLIFGKKVRKLDQVVRSLDCAMMESGHTIPPCERKSQPFFPRVQMVTVQGEKEKVIRSWRKSERQSSGEMLRNLFGAGVREVKKMGRRVGAMSIGSSEDLPSSRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJ49</accession>
    <name>A0A0D2BJ49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238816.1">
        <property type="nucleotide sequence ID" value="XM_016377246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJ49"/>
    <dbReference type="STRING" id="91928.A0A0D2BJ49"/>
    <dbReference type="GeneID" id="27329972"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02889"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF2">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="252" mass="27070" checksum="80DA8CD505BEAB68" modified="2015-04-29" version="1">MPYNLRDRNVLVTGGSRGLGAIICERFAAEGANLLINYVSARDKAEELAEKCKQSFGVKVAIAQGDVGVAADCSRLVQETVKQLGGIDVIVNNAGWTRFAKFGDLNDLSHDEWNKCWHVNVMSQLCLMQEAAPLFNSNPDGGVFLISSSVAGISCGGSSMGYSVTKAAGIHLMKCLASTQGPKIRVNAILPGLLLTDWGKKYPEERQQFIINSAALKHETYLDDCADSFVSTAKNTSITGQQIVVDAGLVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJC9</accession>
    <name>A0A0D2BJC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_02999</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238926.1">
        <property type="nucleotide sequence ID" value="XM_016377356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJC9"/>
    <dbReference type="STRING" id="91928.A0A0D2BJC9"/>
    <dbReference type="GeneID" id="27330082"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02999"/>
    <dbReference type="HOGENOM" id="CLU_034486_0_0_1"/>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF26">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="149"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW18710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45915" checksum="F32E5C11E3217DB3" modified="2015-04-29" version="1">MSLEDDPSDFDGVLPVIPIDSPPIYKDGTSNAATGASAAGARAFAAQAVAFYFRAPVKAFFRTRVDYLAYAKSILPPTQNDRFSWRNTTPGLLAHAIHNYGWRFIPEQLFPPLAANIVVGAALYTSYLQVLGRLYEPSSHASKTVYPPPPPTHTFAAGFAAGTIQSVIAAPLDALQVRFDQRGEAYQNKTMWQYGKGKLHEIGARGIFAGWGLSFLKDSFGSAIFFSTFEYVKAQGYVRFVRWYYGSLGHVAVDKLAHIRGTVATESQPTAVIRPHYALEPGFLMLAGITASVAQQVILYPLSTFQTLHFERLEDLDKKAAQLEHSSSTRQSRGRMLRAYYHAYQETLGQARAQANQVAGMRTWLFRGFWWFTIRQVPSTSAGLIIFELVRRKYGLSGDEVRITEDGYDILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJE5</accession>
    <name>A0A0D2BJE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231675.1">
        <property type="nucleotide sequence ID" value="XM_016385073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJE5"/>
    <dbReference type="GeneID" id="27337842"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10759"/>
    <dbReference type="HOGENOM" id="CLU_022148_3_0_1"/>
    <dbReference type="OrthoDB" id="2831684at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249879" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="27"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="170"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="7">
        <location>
            <begin position="443"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="59277" checksum="95A7030EA3E8B98D" modified="2015-04-29" version="1">MRPSASGTRAWCSSLLLLVAAQTTTSFSPWTRSTALGVTVPASAEGASYGQSSSFASFSFEPAFWVEFFGNASKPNTLTFELLSRIHERGGRPIIRPGGITMDSMIFDASAGDPERTTSPSGGVYRTTVGPSYFHSWSNFPQGTKFVSTLNFGNDSLDIARDMALASVMYQQEKIEYFELGNEPTNYPSTRWDNSTAAYVQQWKQWTGEIDTAVNHTLGANASRLGSDRWWASSATTDKSGLNVRPADIIPAGVDSADQVAEYSIHSYAFSTCDPGRAALATTQNILNHTELTTYADEEIYPSAKAALDSGKPWVVGEFNSISCSGQPNVTDTFAQALWTVDVELIYAVRNASSVHLHQGATLVFQSDNQVNSAGSDGSPGYSTYDILYPRDSRKRGKARALPSFVSQLFMAEAFHTSQNGAAGVRVKELKPPQGVDSARFAGYSFYVNGKLSKVALLNMKPLYANSTEDFSLDLNLGLSGQAWVKRMTAPSVDETRSQNVTWAGQSFPNGEAIGKLEIEEVGKGGSVSVRGSEAVLIFLDKNDVYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BJG4</accession>
    <name>A0A0D2BJG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PV08_03318</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239244.1">
        <property type="nucleotide sequence ID" value="XM_016377674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BJG4"/>
    <dbReference type="STRING" id="91928.A0A0D2BJG4"/>
    <dbReference type="GeneID" id="27330401"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03318"/>
    <dbReference type="HOGENOM" id="CLU_022550_2_0_1"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="20">
        <location>
            <begin position="190"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="535"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="234"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="302"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KIW19028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="579" mass="63717" checksum="871613CA94F5018D" modified="2015-04-29" version="1">MSSSDSIISSSNRGSNLATATLSDASSRSHGINDNPRPTFPSALDSSPVPNPLIRSGSGQSNQMSIAALIDPPLPGPTNDQITEERRRSIIARDRKRRLTTTVEDGRRRTNSGSYYDRRTAHDAYRMDGPSTQMRNHTVAANPAPEVIDLTETTPSPSQASALYRHGETRMNPTSSASSGRYVVPRWQPDSEVNECPICKRPFSWMFRRHHCRKCGRVVCNDCSPHRITIPRQFIVHPPGPDTVPPLGQGARSRHDPIDLTADGNDDDPFDNPASPNPYLALDGGEKVRLCNPCVPDPQPDPFPHYPVLENEPSRRESPWSHTLGHARASSHPQGLGNRPPIPARNDSLRNPMRYDGSGPLPNRSSWTGPHPSLTSPSQYSLSALVGEAASPAPSRDRFASERRPSYGNSHSHSRQPRDEWVGGLSRSTYVPPRAPYETTATRFPVTLPSIVDGPSRPRLDERDICPICQRALPPKEPDGTETAREEHIMSCIVARDPSARYEGAGGPSQARIYVLPFTATEKDCVGEDGGPQECSICMIEYDVGDELARLECLCKFHKSCIIEWLGRKAECPVHKLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK93</accession>
    <name>A0A0D2BK93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239196.1">
        <property type="nucleotide sequence ID" value="XM_016377626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK93"/>
    <dbReference type="STRING" id="91928.A0A0D2BK93"/>
    <dbReference type="GeneID" id="27330352"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03269"/>
    <dbReference type="HOGENOM" id="CLU_2542594_0_0_1"/>
    <dbReference type="OrthoDB" id="5415741at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="83" mass="9312" checksum="FDB89EFEC9AF9D88" modified="2015-04-29" version="1">MSSLGYQYEAIVRSTGIPRRSVVNIIKKARERGFNPQQDPRVLDHFIIDGYKPGRPKGTKETAEREGPADIPQDRASREESSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKM6</accession>
    <name>A0A0D2BKM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">10 kDa heat shock protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232040.1">
        <property type="nucleotide sequence ID" value="XM_016383417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKM6"/>
    <dbReference type="STRING" id="91928.A0A0D2BKM6"/>
    <dbReference type="GeneID" id="27336180"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09097"/>
    <dbReference type="HOGENOM" id="CLU_132825_0_0_1"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10639" checksum="E0FCF7DFD6560E35" modified="2015-04-29" version="1">MQTTALKSIRSLAPLLDRVLVQRIKAESRTAGGIFLPESSVKELNEAKVLAVGPGAFDKDGKRIAMGVKEGDKVLIPQYGGSPVKVGEEEYHLFRDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKT7</accession>
    <name>A0A0D2BKT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="9">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_03509</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Endoplasmic reticulum membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239431.1">
        <property type="nucleotide sequence ID" value="XM_016377861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKT7"/>
    <dbReference type="STRING" id="91928.A0A0D2BKT7"/>
    <dbReference type="GeneID" id="27330592"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03509"/>
    <dbReference type="HOGENOM" id="CLU_020802_1_0_1"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW19215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="558" mass="60388" checksum="A2D73BCAD30DCB1E" modified="2015-04-29" version="1">MNPSEAISYKARKEAFVSNLSGSSLTDINLVALVSSAAVLLWTALQKRQSFFTPYTPVSLVADFLLNVCAILFAVTLYSATPIVLSIFLITPALLLLFLTSAPSNLDSSSSLSSKKSNATKIASKSTNINISTDANPSPSTAKTLPVRPFLTHYRGSMLVVTCVSILAVDFPIFPRRFAKVETWGTSLMDLGVGLFVFSAGVVSARAIVKPSSSSSSFVSRFLISLRHALPLFILGIIRLLSVKNLDYAEHVTEYGVHWNFFFTLCLLPPFVEISDSLTRHVVRSYDLLAVLISVTYEFVLNSHPTLLRYILISERGPSWLSKNREGVFSFIGYLAIFLAGRGTGRQIVTFNTPPTSSGSSARAKPKSSQLMMMMTTTSVDDVRNERRVVLRTLAVRTLIYSALFIFTTNIYGGNLTVSRRLANLPYVLLVAAFNNGQLFLFGVVEDLGPEFIYANAAAADEDSSRGSSSRQRQSKAGGGEGGKARGVSFATSRILRVFNTNGLVIFLVANLLTGLVNLTVNTLDMAALPAMAVLILYAAVVTGVALGLDHAGIKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKW8</accession>
    <name>A0A0D2BKW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-protein ligase E3A N-terminal zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_00151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239794.1">
        <property type="nucleotide sequence ID" value="XM_016374518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKW8"/>
    <dbReference type="STRING" id="91928.A0A0D2BKW8"/>
    <dbReference type="GeneID" id="27327234"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00151"/>
    <dbReference type="HOGENOM" id="CLU_012913_0_0_1"/>
    <dbReference type="OrthoDB" id="193703at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056012">
        <property type="entry name" value="DUF7590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF15">
        <property type="entry name" value="FUSION DEGRADATION PROTEIN (UFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24503">
        <property type="entry name" value="DUF7590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23580">
        <property type="entry name" value="Znf_XAF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="3">
        <location>
            <begin position="169"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7590" evidence="2">
        <location>
            <begin position="271"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="85515" checksum="6D0DD0D05B755A28" modified="2015-04-29" version="1">MASSPDTLQWSAQLEVAPSNRRLVGDKITLPQSALEALLAAAPVVSVQSSSRNLTSTFDPFNPYTFAAERHARAAVEDRQQQLPHPLTFRLVNPLNGRAVYAGIREFSASEGTVGLSSGLREALGLSNDSSSQTSRESTPGGDIAMSNGLHPAKAKGEIVTIHAKQLQKGTYVKLRPLEAGYDPEDWKSLLERYLRDNYTTLTSGELLVVPGARHERFRFLVDKFEPEGDGICIVDTDLEVDIEPLNEDQAKETLSKQLARKRRQQDLPEGSSSGGSLFLDTDVHGRVLAGEYVDYELKTWDRSQDLELVLQASDENSSLDLLVSPFSARQRSKPRQDEFVFGELNARPTKRIKLSHTNVDLEMAEALNVAVYAWHDPVSGTVDEIKPIPYTLKIAPATLEDDRSDSAAQELAADEVICKNCRQVVPKRTLPLHEAFCYRNNILCPKCAEVFLKNSDSWKNHWHCPHDDDHGNDPASHRKHDSIFHPKTPLQCASCDFEAFDLPILAHHRTTTCPGKEILCQFCHLVVPQQGPDDPAFTDPEVLLSGLTPHELADGARTTECHLCNKIVRLRDMKTHLRLHDRERFSRPRPRLCSNQICGRTIKHEDEARTQKEQLGLCNECFGPLYVTAYDPEGKMLRRRIERRLLQQLIGGCGKSWCRNGQWCKTGYKNVTGEDRVVSAKDGLVMLKPIVDQLARGITSGLVFCVDEASQTRRSLATMMAGEGEYELEWCVKALEEERNDVGKARDWLRDRAPKIDEVVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BKX9</accession>
    <name>A0A0D2BKX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239476.1">
        <property type="nucleotide sequence ID" value="XM_016377906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BKX9"/>
    <dbReference type="STRING" id="91928.A0A0D2BKX9"/>
    <dbReference type="GeneID" id="27330637"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03554"/>
    <dbReference type="HOGENOM" id="CLU_449792_0_0_1"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000060">
        <property type="entry name" value="Nudix hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="420"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW19260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="631" mass="70599" checksum="2FEE40DF8DF7F6BA" modified="2015-04-29" version="1">MSTSSDQGVSSITVSVEEIDSMMSNHTMRHSLERYVFDKIHQDIRERHWKRISVHGHYQRDGTARLSVFEKQGKRFNWHRPTSRVVDGDTLEINCFPGQAYVKHNAYLIAMYLRLQELQSPSTDGPPLSFSRPVVEYRLPGVEDSALIFAESNLRLMGKVDIVVLGYAEAVLPTTGGDWESGTVDPERQLFAWQKITLPDGKVVSYLGCMISLWGEIVGSLIRVLKELNNASHVVFLGKAGSLRNYSPAGGLLIQPNRILVTGSSSCMEQERLQWSSPFYYDTSREGHGSTELVVGQNVSVFSPLVENAVWFEHWRDKADWVDCEVFHAATACRHVNINFGYLHIISDVLARYEPENLSNERDLLILSHRRSAFDRMKRILDSCLTSPLSGRISPQPRLRDNAHWTDPSHTKHELLASEVPRVGVGVFIIHPTIPKPTSKPSPGSSDETRAWKFLMGQRLGSHGSGTYALPGGHLEFGETFEECAAREVLEETGLRVHDVKFLTATNNVMGEDEGGKHYITVFMTARVTMDPGDSAAANVGEDGLPIARLMEPEKCAGWEWVSWRQYEMWAMAQVRWGKLNHDKHSDGGGDGDGDGSGGNHVEGRLLFSPMVDLLVQRPGVVPELRMIPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLJ9</accession>
    <name>A0A0D2BLJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240039.1">
        <property type="nucleotide sequence ID" value="XM_016374763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLJ9"/>
    <dbReference type="GeneID" id="27327481"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00398"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000313">
        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="30"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="546" mass="61113" checksum="A274B50479EDB8EE" modified="2015-04-29" version="1">MPKSNNLISLTKEAVRESPREIFNWYLIFCTLAVSFSGVAKGFDEGNIASVVVMPIFMKKFGLDSQSDAEYANTKGWIVSIATAGAVFGCLICSWLNTRFGRKKTLLIYTIIYMGGIFGQTFSNGSLAALYVSRVIAGFGIGGTTVVPSVYLSEIAPRPIRGLMTVQYAACQQLGVVFGFFFNYGITKYHKNTELQWQLPTALQLVPAAIWGIGTLFILESPRWLMSVNRQSDAIRNLTRLRHLPEDHPYVREELAAINLQILHEVEVVGGASQWSLMKETFSTVQNRRRFFLMLGAHTFSQWSGANAITQYSPTILGYLGITGTEVKFLTTGIYGIVKFVSTLLFALFIVDFIGRRRSLITGICLQITTLIYIAGYLGATNGMSASYISSHSVIENASTVAIVAIFLHAVAWSIGWFSAPYLINSEIFPIRIRSFNMSVMMAFHWLYYFGCSRAMPSLLAATDRYGAFIFFASICIISLVFVFFCMPETSGRSLESMDALFERPLYRIREIAYPTKEDLERAADLHPDDIKEDKHEVQEEEIIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BLT1</accession>
    <name>A0A0D2BLT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00072</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239716.1">
        <property type="nucleotide sequence ID" value="XM_016374440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BLT1"/>
    <dbReference type="STRING" id="91928.A0A0D2BLT1"/>
    <dbReference type="GeneID" id="27327155"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00072"/>
    <dbReference type="HOGENOM" id="CLU_009646_3_2_1"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF332">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="179"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW19500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="571" mass="62203" checksum="9009D9643B1DEE3A" modified="2015-04-29" version="1">MADTPSSQQDAQAARVISGHLPSGYTAEFVPESDSGDASKDPNDGEGESSLQLQGGDIHRDLFKIHHRGKLQQRAATFSYPRADSTNDEDEQPTVAGHLVPGGFRREFVKQKYGRFNPAVMPVTRNFVEFLALYGSFAGEDLEDTDDEDALEDEEEAPTETRPLLSRRRTTTRAQRGDAGTTKTFFTLLKAFIGTGIMFLPKAFNNGGILFSSITLITVSLVTTLAFHLLLQCRQVHKKTGYGELGEAIGGPKLRAIILGSVTISQLGFVCAGTVFVAQNLHSFLQAVTKGPQPPLSTNILIALQLLALIPLSYIRNISKLGPAALLADVFILLGLAYIYFYDISTLATDGIHPTVQLFNPDYYTMTIGSAIFTFEGIGLILPIQSSMKQPEKFEPLLWVIMLINTVIFTSIGALCYATFGSATQIEVISNFPQNSKLVNAVQFLYAIAVMAGTPVQLFPALRILEGKVFGRRSGKRDASTKWKKNGFRTALVVVCVLIAILGSNNLDRFVALIGSLACVPLVYIYPPLLHYRGVAQTPWAKIGDVALMALGTVCMIYTTIITVVNSFLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMF2</accession>
    <name>A0A0D2BMF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232570.1">
        <property type="nucleotide sequence ID" value="XM_016383947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMF2"/>
    <dbReference type="STRING" id="91928.A0A0D2BMF2"/>
    <dbReference type="GeneID" id="27336714"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09631"/>
    <dbReference type="HOGENOM" id="CLU_015530_0_1_1"/>
    <dbReference type="OrthoDB" id="5342758at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="67060" checksum="2CD4459CD0BE22DC" modified="2015-04-29" version="1">MQKSFIERIFPHPSTKSHQHFADDDLERPGSSRSPRPIVLQDSVAPSSRSRSRSRRGSSSASASASASASHYHVPSQALSSASLVRHNDPFLPVERAARNLERTLQDLLDVQSDGLAAGFGAGSGHESSSVGSPTPTPSVVTSSGPHTSRPRTMPIRQPKKKRLTLRDARRGLSRSLAEFTALKDHELKIIDGEVLARNDALREASDLESRRQLLDAQVRKIQNQAVAVDLRREAHQVEQEITELETRLLELRNRHRHLLDQVREHESSQDSELSSYTEALKLNENSIRHFLRLPPVAQGIGAGGVQGMYAFKPERRTLQMAQDQWTNDLDLLSARKADVARERQALDEGGKLWHEVSHRIREFEKDVRDRTKGLTRSRAALDAVEGDGGSTTVPVDDDTGISPIVENMYNLLDFLQDALAKAEIQGWKLLICAIGAEVAAFREARDALDPYVSSTRNGDLDRGMTGPPKGFEEEDGEHQDEPRRDLLGGDVDAHPNGRANASDLEARDRTQSPSEESNHSLEATLRHFGNGLDSKKEGADGGHQVLHTDNEGAVSGDDVVPGGGGGDAADNGGDSGKASSESRLQADAKVLLRGHTSESEDDEPGPEFLLSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN05</accession>
    <name>A0A0D2BN05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240539.1">
        <property type="nucleotide sequence ID" value="XM_016375263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN05"/>
    <dbReference type="GeneID" id="27327981"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00898"/>
    <dbReference type="HOGENOM" id="CLU_310791_0_0_1"/>
    <dbReference type="OrthoDB" id="5404004at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="864"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="986" mass="106783" checksum="FBCA6D537B7632A0" modified="2015-04-29" version="1">MLTRWYSLRHRETTRQPNISDPQALTRPSDFDFAFPETRATATVRSPTGETVLSPRPVHLRPRTSGAPTAKRKPRTDAPPARPKTSENHKQSKDPRADLESEDPSIGLAFGSPSHPPATFGMPADNDEHDSSPLQRFIRAERSRQMQSKKWKKIGTLFKSRQIALRREEIPSGPTIGLPTGFTVLDKSPTSQSVEFSEHRLRPIGDVGQPYRQRLPPKGKDSGTHKWPLDKSHHTTDTETVSRPSTATDSSLWVEPDSRPPLPKLELDIPTPPLDRYSVMFRNLPAATRSSSLLARRSKTLESLVSLDELRSGVKAPEEDGLTTYYDPATPLVPPQRLGSPTNRSPVASKYSLFPNTSPAASKVQARVTDGNNHQLKRTASSPARLTPMKDRFSVDKPEPLNPKRIEVNEQPVSSPEDNTASTDRSAPWSAAHSFQSSISSVATGEEIFFDIRSFRDSKGVEDGQFVMTRPDSVAVELARTRSKKTAGGSNLREAQSGRPDHETVEEEPLTPIPQPTSLSGMTSATTTKHTSVNTAYFDEAIAAVERLTSPTSASQEKLPPVTFTVPTLHVPPQPENAPAPPSDSSLYSSRPVDHTGIRTLSKAREGVGLMIPSPVPEAKEDLSPKSDVTITNAPAPSLLSSSSVVSSSSKPLEKPQTGQILSPRVIAIKRVDRPIGDSPTIPQGPPSPPRRAPAPKPQPQPQPQSQSQSQPRSATSSPQSDDKPPPVPRKDSKFIPLSKYATKSTVAKIEQAGIIPTRPSRSNTDTLLQGSSSASSSPFIPGRSASPLVRGAKERSATLPTSLQGLEKTIPPSRPPRPNPMAMNPPSSTAPEVAVARTVSLSRKQSARINVTAPRLAARRAEAAAAALQKAKQQSSSSSGSPPSPSSIAATVGSSLERGGSKSGMGILGHHHRHRRSGSKSLSRDRIKIVKREPDAKKVRDAEKQMVKEAKKWELLERKAYSPVVVQAERGHKPGLSVGLVVERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN26</accession>
    <name>A0A0D2BN26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240559.1">
        <property type="nucleotide sequence ID" value="XM_016375283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN26"/>
    <dbReference type="GeneID" id="27328001"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00918"/>
    <dbReference type="HOGENOM" id="CLU_368807_0_0_1"/>
    <dbReference type="OrthoDB" id="4157485at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
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        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="703" mass="77924" checksum="F4D8328ABB8F22F8" modified="2015-04-29" version="1">MVHTRGQGARPEGFSEYQPPKRERKMAHSHVAARTSPVHATFVSRYKDASTQTEDVYLTTQIEHPGSKRRREDDDSENSSKRQRQAVTPEQPRRGNTFMFSATRNRSLLTSAPPKIPSRRDSPYGRKAITPVERTNTPPKTSENRDESDERAKEPETPNPAPARAGGLFGSVRKIFGYLTGGPSETGQAGQTRQSGSEAENVSPKQTPLDHNNYASDMTSPTPRTNDPALPPSEVPADDSVFTKENWKRRRAMSTRAGREALAALRDTNTETEMAQFNPTETPGTNKRKLASFNGEIPPPTRGGFGIDENYLDVDNEVDGLEESRFANDDPSTPANKTAPQTPLRSALRANGYATLGRSGKSVRINPQTSVKHVYGTYGRSGIYHGSMFSDPSDRSKVSDSSASSISARDVSAMHSPSTLQNTVNNMTPKFRLDHSVVDPNDTTWRPSLANPSPGHFRVPDMDEYEDEEDTIILGQANDEVIPPRPSTPRMSHAELPGSSSSLIPSSTVQDESSVNDTTESRLEKARSEAQKYKPVRSSRLSLTEKARSRSSSPPGEDVGEISSFRESQIEVSDTPPLRARTHPDTPNNTTMSSTLSPTPKTRKELDNTNVGTDGMTDYQREHQYDEWAAGLDWPQAQTYVEAGIASQYIDNLVRKNWTERDTEESAEFWAREFDRGEEYARQAAAEGKELVWITDPEEMIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN87</accession>
    <name>A0A0D2BN87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232805.1">
        <property type="nucleotide sequence ID" value="XM_016384182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN87"/>
    <dbReference type="STRING" id="91928.A0A0D2BN87"/>
    <dbReference type="GeneID" id="27336950"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09867"/>
    <dbReference type="HOGENOM" id="CLU_033465_3_2_1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF32">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW12589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32521" checksum="6292C14BAABEA75B" modified="2015-04-29" version="1">MSSSNNQTASSSDDPHLYFYSPSTPAAVVFSILYLLLTLWHFSLNFIVARHCLVKHKYTIPLFIAALISTAGWVVRILSVRNDTSIPLYAVSSSYIVISPIFVCASLYLLLTRLIRATLPNGPAQSFFRIRPSWLGRVFITSDVFSFLTQCSGSGIASSGNWEGNMKDIGTNVLLVGLALQLATFTVFLVVMARFVRRVNRRQDTGFETGVKKVIVGASIASGFVQIRSIYRVVEFAVGIDGYLFNHEWCLYVLEAMPMFFALAVLAWYHPIRWMQEKRRSDFGMENIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNG5</accession>
    <name>A0A0D2BNG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_00645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240286.1">
        <property type="nucleotide sequence ID" value="XM_016375010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNG5"/>
    <dbReference type="STRING" id="91928.A0A0D2BNG5"/>
    <dbReference type="GeneID" id="27327728"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00645"/>
    <dbReference type="HOGENOM" id="CLU_000702_0_0_1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239125" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="27"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="926"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1091" mass="116370" checksum="D1C15ACF4E3E5A5D" modified="2015-04-29" version="1">MHYTLTQSLLTIVFLFNACFLSNVNGLASTDTITWGGSNDRTGYQNNHNMDPAIVGSAQFGLLYKTQLPGTYLINGQNVPEQIFSQPLVYTGSDGLQFVYVATTQNNVYKINAKTGVIVASRNLHRPFLVSDLNGCVDINPTVGVTATGVIDPDTDTWYITSKTYINQDITGPTGRPNGRYYVHAINTVDLTERPNFPVNLEGMVARNNPARSFSGGIHHQRPGLLHTGDYVYAGFASHCVQWNFTGWIVGWHKQTGQLVERFATEGAGVGPNVPGAGVWMSGGGLASDGKGSMFFASGNGYASQLNGVPVNGRNPPSALEEAAVHMSINGDGSLTVVDFFMPWEKVQLDGADKDLGTSPLELLPSQFSCGNITRMGVVTGKSGKTYWLNLDDLGGYQNGPNKLDNVIQVYQNENSVYAGAGVYPLEGGYIYINVIQYQTHVFKFSCDNGVPYFNKIADSPEKNAYILGVGHGTVTSLDDQPGSGLLWTSDVEGSNLRIYNAIPENGLLNEINSFVTPGTTKFTRPVFGDGIVYQGTTLGYLYAYGAPVNLPLKCTPAQFGTTNLNTTSSPVPIQCQANTALTVTAATLSGNANFKFSGLPTLPFAVNQGQNFSFQTTFTPQTVGPLSSSIILNTTQQAAGFSINTPVNLKGTGQSQAPLLMITPNTVSWNGVITGQVVGGVNQSIILSNLGNTQLTITGISYSVVGETGPWISPNGTQAATVVSAFTFYSVPSSVAANSAVTIPINFNPSSSGNYAAFVKLDSNGGSKVLDVLAAGSDQPKAVLEFETPDGGWIPYRNSTPFSFGNVTENTTRYLKLRLSNNGTANAAPISVTVSKPPFGVSGLIGSNNNIDLAEGTLVYAGQNQTATLYCSVPKSQINVDPYNGSAQWTMNLNDPSFGKQFIQFSCNALSEQAPPLNPLTQQGIYRYAGCFKENNPGRQLQTNIYSGSLNTNEQCIKQCSTAGYIFAGTQYTQECWCGFNRPKQVVDDANCNFACTGNVNEVCGGNGITGTGSFISLFGDITRWNGNRTDTPGPYVNPGMLGFNSLGCYAEGSQTRALNVQPTSNNTVASCIQACQGYLYAGVEYGGQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BP54</accession>
    <name>A0A0D2BP54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240521.1">
        <property type="nucleotide sequence ID" value="XM_016375245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BP54"/>
    <dbReference type="STRING" id="91928.A0A0D2BP54"/>
    <dbReference type="GeneID" id="27327963"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00880"/>
    <dbReference type="HOGENOM" id="CLU_031225_0_0_1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000229">
        <property type="entry name" value="HSF-type DNA-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF396">
        <property type="entry name" value="FLOCCULATION SUPPRESSION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW20305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="568" mass="62071" checksum="6A5CAFF09E39863F" modified="2015-04-29" version="1">MSTLFQSTLRNPFDPPLESLSGPRAMPILHQNNNTSPKSSHEDSMQASSPAPSNMGPPAQGTSPEVDQGNSANGGREHVGLSMNNAAAGAVGASQGPKVVQTAFIHKLYSMLEDKSIQHLISWSNTNESFVMSPSTEFSKVLAQYFKHTNISSFVRQLNMYGFHKVSDVFHTGSPDSALWEFKHGNGSFKKGDLMGLREIKRRASRHTLIHRDSFSNAKSGASQPGTPADMISDTDQRLAMLENTYWDIQARLQRTEDRCQTLTEGMIRVHQLSQNLTSAVQTLSSPDSALYNDIANMQKEIARQLEFVRGLESQSDTLHVGRQSLFPNGGALEPPVSPRGYNYPDSRRSSIQIEPQHVGLRPPVPPLPHFPSSPRRFGSVSIPHPSPGFSRPALPTQPPPSVHPLASVSTPPPLNLARRHTSADIREHGWPPSTDNGNGSPYASGQSSVHWQPSSPQQGPQAGDRQLQDQLARYEINGSKRHATTANQPTPPLTSSSEAPPAGLGVENVLWTPASSKFPRPNFELHSAPATRRGSMATLQLLLNPAETAEQENEDEGNDDRKRKRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPA6</accession>
    <name>A0A0D2BPA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240984.1">
        <property type="nucleotide sequence ID" value="XM_016375708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPA6"/>
    <dbReference type="STRING" id="91928.A0A0D2BPA6"/>
    <dbReference type="GeneID" id="27328429"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01346"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_2_1"/>
    <dbReference type="OrthoDB" id="5421817at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="7">
        <location>
            <begin position="380"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="6">
        <location>
            <begin position="655"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="889"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="922"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="955"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1055"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1119"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1196"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="758"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1275" mass="143094" checksum="03F5C4F9EA6C8FAF" modified="2015-04-29" version="1">MSNPQDYTVGWICAISTERVAARAFLDEEHAPPEYVQTNDNNDYTLGRVGKHNVVIAVAPDGEYGTQSAAAVARDMMHTFPNVRIGLMVGIAGGVPSHKQDIRLGDIVVSSPREGKGGVYQHDFGKRRQEQDFQTTGYLNQPPPVLRAAVAGLRSQYEEDGHQLEHAIDRVLEKKPRLRKKYQRPDPKNDRLYLSKIVHPANDERDCSEVCGQDPSQFVDRGIRTPEDDNPTIHYGLIASGNTVLKDALLRDAAAKDGVLCFEMEAAGLMNQFPCLVIRGICDYSDSHKNKQWQGYAAMAAAAYARDLLLRILPNRVEAEKPFRQTVSDSIKNVQDNIENLARGQQQQIERKDRRKLSEWLSPLIPYARHYENQKQRVNGTGKWLLEDSLFLEWSTATSPSVLFCYGDPGAGKTILSSLVIDHLHSTTAESTIGVGYIYSDYRDAKSQTAENILGAVLQQILGSLPEIPPEVWSLFRERLAKHLAFHLSDAKDLFQIASVKFGKIYICIDALDELNDQRRVLEFLRDRPSNLQLFLTGRPHVREIVREHLNVLQEVIVKARDYDIQQFIDREIGGPNDIEPSAMDDKLRTSIKEKLVQSAEGSFLLPVLQIRTILQCLTRRDRELSLKTLPSTLSEAFAGSFARIQQQPEALAYRAAQIVAWVHLTVRPLTESELLCALTVKNEDTRFEVRGIPVRRTLLNCCQGLVVMDRQTSTVRLVHFSLEEYLNRQNQIFEVSIRELHGRIAATCLTYLNFPTSAEDPDEDPNEDPDEDPNAHPEEDACVNVDIRMALLSYSARHWGIHLHHYEGEEGVDHVEPSVLNLAYKYLQLGWKRNPDSWKSLLEYMYWRDVPKTERRDLQAHVSAYFGLRSVISLFALRGLSLDRKDRMERTPLSWASERGHLGTVQLLLAKGVEVDLGDFFARTPLSWASKEGHLTTVQLLLDNGAAWNSEDDLGYTPLMRASEQGHLAIVQLLLHRGGATVNSEDEELSASLFCASGNGHLAIVQLLLRRGVTVNWEDPEGRTPLSWASENGHLAIVQLLLDHDAALNSKEEEKCASLLWASEWGHLAIVQLLLDRGAPVNSEDEEGRTPLSWASENGHLAILLLDRGAVVDSRDSGDRTPLSYATEFDSILVAELLIKEGAAVDSVDTTGRTPLSWCLAPEMALTWKEDTTETKAVAQLLIKNGAILDTRDDEGKTPLSHAAENADVMRMEILIELGAEVNSRDNNGRTPLSWCLSSKTEYSWTRTKKPWEIAARLLIKNGALRDPDTELDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSM2</accession>
    <name>A0A0D2BSM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234490.1">
        <property type="nucleotide sequence ID" value="XM_016381388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSM2"/>
    <dbReference type="STRING" id="91928.A0A0D2BSM2"/>
    <dbReference type="GeneID" id="27334139"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07056"/>
    <dbReference type="HOGENOM" id="CLU_003864_1_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="305"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="730"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="730"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="859" mass="95210" checksum="EDE48AC56E26DF0F" modified="2015-04-29" version="1">MRQALHPREEEALSPHGSGTRVCKHPDVLPPVRDESAVGGNVSYERVENPGEQPLADGPPNGSLADSVTPNVPVAVAGSPTWPDPAPPLSVQNPAAYSDSYFRDPGFSVDFNQQVLYMNWWSPSIDDVADWQIQQELVSTNIFPSFDASILCTEVNMPNSATTQTGGIPPAQENELMEIPSAVMRETDMHGSPHTELQSSMAQSDKTGSSSGSTVGRYYVDGVVARAALPGRFHAQPSIASPSSESINSASMASANPPSAASISFVSPTSYRTVRENLLSETPPRSRESVLSWFPTLHELSWHVQTYFDRFHSTMPFLRKATFQSAEPHWLLTLAVATVGAQYTAPESTKPMRNVLHEALQQHLNAAHRHNDVTPGPSDLPSHSGRISYLDLQVLQAAILNTLLLLHSGVQEKINSALLEKSRLVEMCDTKNLFRLACEPKRSTSNVGRDIRDWLERQALLRTGMMIWLLDAIFSYEVNSQPRMAFPPPDTPLSCSERTWEMPSEESIASETSNSLLFSHALEMLYMEKRLPKNLGDFAHVLLIHAICRRTKDVFSQAQSRLSFWTPSAAVQTRIPALATGDTCPPSNEMSLKWRNSACDCLDILHWQANGRIAESAGWEHPTVLHLHLARLLILTPTVHLQTLAANPMLLGNPDVAETPFNASRKHLINWATHDQYKARLAVIHAGALCWHIRRYSVDNVLEPFAVYMATLVIWAYSVVLVSTKISNNRQGNISNPDSMPGSQRLSGMPMQTASSTNETEIDPSMLYVDRPCDDEMVQNFARMGHKMTARMRGIPDISAPEAPKKILQEGICLLRSATGNPEARWNKFSPSRQELSPEIWGVQKQYLESLSWLESKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BVM7</accession>
    <name>A0A0D2BVM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_05390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235560.1">
        <property type="nucleotide sequence ID" value="XM_016379733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BVM7"/>
    <dbReference type="STRING" id="91928.A0A0D2BVM7"/>
    <dbReference type="GeneID" id="27332473"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05390"/>
    <dbReference type="HOGENOM" id="CLU_061239_1_0_1"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239338" description="Cupin type-1 domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="7">
        <location>
            <begin position="105"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW15344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="278" mass="28758" checksum="5EC3FB9E013FB75B" modified="2015-04-29" version="1">MHSASFVVAAFAAAVYASPMGPPSGSGNYNGSAPGGGQGYPSSTASYTTGLLGNPTAAPNPVPTSGVIAELLTADNTVVRFMDIQKEIAAGDISLKFDFNPAANPAITAKAGEGGQVDLASRANFPILTGQGISAAGIFFEPCGLNTPHVHPRAAEFLTVATDSNIFTGFVLENGLTSEFNTTLTQFQGTVFPQGSIHFQQNLDCYPAVAIAGLNSEDPGASSVAQNFILSVDEGIVDATLGFPKQIDGSNFAQFKKNILPPLAKGVEECLIRCHIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXH7</accession>
    <name>A0A0D2BXH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBR7"/>
    </dbReference>
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        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zf-UBR"/>
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        <location>
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            <end position="127"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="49"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="339"/>
        </location>
    </feature>
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        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="311"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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        <location>
            <begin position="489"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KIW15979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="498" mass="54787" checksum="7E091BD7D04EF98C" modified="2015-04-29" version="1">MDSNSDIERANQVQNHGQATQDSQTASDFIDQQLALEADAREVLPYKFDKCTHVLGPLRQTIFACLTCSPPPASAAQVYTPAGVCYSCSISCHGEHNLVELFSRRNFVCDCGTKRLPSTSSCMLRSDPTTGARGVHSQEPAPNNQYNHNFQNHFCACGEEYDPETEKGTMFQCLGLGTVESGGCGEDWYHPECLMGLPRDWYKEDKAPQGREKEEGEPSHPTPPGFPSEDDFEHLLCYKCVESNPWIKQYAGTPGFLEPVFHRSPEPKVDNQAPDNSAPPTNGTSLKRKASDTDLDKPPSSPSKRIKDDLNTLSLPTSAEPSSQPSNDTNSAHKHELLPPAPEGTFSLFLTSSFRDHICHCPQCYPKLIPHPQLVEEEDTYEPSLSDASSQANSAGVPGSGTRSHGTASLLDRGEAALSTMDRVKAIQGVMVYNHLRDKVKEFLKPYAESGQVVSAEDIKSYFEKLRGDENAIKEARDKPVDGNEDGDADNRREQSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BXW5</accession>
    <name>A0A0D2BXW5_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_06175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016380513.1"/>
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    <dbReference type="STRING" id="91928.A0A0D2BXW5"/>
    <dbReference type="GeneID" id="27333258"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06175"/>
    <dbReference type="HOGENOM" id="CLU_061288_2_1_1"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calmodulin (CaM)"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="CALM/Myosin/TropC-like"/>
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    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
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        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
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    </dbReference>
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        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="efhand_Ca_insen"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
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        </location>
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            <end position="176"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW16124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="209" mass="23402" checksum="E6685B9303A65ECF" modified="2015-04-29" version="1">MTSGCFSQALATAQATDMPTPYKVLVGRKNNTPSAPRSYDSLALYHSIATTDSSFARLPNMADSLTEEQVSEFKEAFSLFDKDGDGQITTKELGTVMRSLGQNPSESELQDMINEVDADNNGTIDFPEFLTMMARKMKDTDSEEEIREAFKVFDRDNNGFISAAELRHVMTSIGEKLTDDEVDEMIREADQDGDGRIDYNEFVQLMMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BY48</accession>
    <name>A0A0D2BY48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_06290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016380628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BY48"/>
    <dbReference type="STRING" id="91928.A0A0D2BY48"/>
    <dbReference type="GeneID" id="27333373"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06290"/>
    <dbReference type="HOGENOM" id="CLU_031468_10_3_1"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="7">
        <location>
            <begin position="162"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="8">
        <location>
            <begin position="309"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW16239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="492" mass="54606" checksum="30A89E97BD95BBDD" modified="2015-04-29" version="1">MAQSHSWWSPVPSDEHASVSGQASFESKPLDEDVVSEPDEERLLTRRVHILGLGSIGTLVAHSMRCLPNPPPITLMMHKREQYAEFKKAGRNIALIDQKNNINDEQTGYDVEVYEGEEPEAGPTWRFMPDFKSKPGRGATPPVTNPLETGESLPDGKVFIYCLIVAVKGHATVAALRSVKDRVDSRTTICFMQNGLGQIDELNRDVFTDPATRPTYVLGIVSHGVYMADPCKVVHAGYGTIALGVSRDRDRHPLPPPALTRNISDLTDDERRKFYPSDKDLFASMSSRYLLRTLTRSTVLACAVFPYLDLLQLQLEKLAANAVLNPLTALLDVPNGALLESNEISVVQRLLLAEVSLVIRGLPELEGIPNVKMRFSARRLEQLALAVTRRTAQNSSSMREDLRHGKKPEIDYINGYIVRRGEEQGIKCALNFMLMQLIKGKDGLQKRDYGIPQGIPYGTRHIGVQANPNQPGIVTLSDESTPNPLRTTTNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C161</accession>
    <name>A0A0D2C161_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237640.1">
        <property type="nucleotide sequence ID" value="XM_016378963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C161"/>
    <dbReference type="STRING" id="91928.A0A0D2C161"/>
    <dbReference type="GeneID" id="27331701"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04618"/>
    <dbReference type="HOGENOM" id="CLU_115019_1_0_1"/>
    <dbReference type="OrthoDB" id="4892971at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02118">
        <property type="entry name" value="EthD family reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260:SF2">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11926" checksum="B822153F85484584" modified="2015-04-29" version="1">MGYQFQVLYPNDEGSSFNLDYYVNKHMPMVMERWGKFGLKGYTVTEYKPGADGAKPKYSAAGFLFWDTAEDLQAALASQEDLTAIFADVPNYANVEPVVLSGPVVGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3S3</accession>
    <name>A0A0D2C3S3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M43 pregnancy-associated plasma-A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238510.1">
        <property type="nucleotide sequence ID" value="XM_016376940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3S3"/>
    <dbReference type="STRING" id="91928.A0A0D2C3S3"/>
    <dbReference type="GeneID" id="27329665"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02582"/>
    <dbReference type="HOGENOM" id="CLU_048726_2_1_1"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="9">
        <location>
            <begin position="120"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="171" mass="18074" checksum="6291B4C725F27AA1" modified="2015-04-29" version="1">MVRDQFKYLAAAYTDAGIGFRLAGVDRVTNDTWARNGDDANMKRALRRGTYSALNVYYQSLLQADSNTPGLPAGSVLLGFCTLPVAGVYAGMDPAAYALDGCNILSATMPGGSYAGYNLGGTTAHEVGHWNGLLHTFAGNSCAASDFGDYVADTPQERTSTSEYCCVPPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C493</accession>
    <name>A0A0D2C493_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_02712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238640.1">
        <property type="nucleotide sequence ID" value="XM_016377070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C493"/>
    <dbReference type="STRING" id="91928.A0A0D2C493"/>
    <dbReference type="GeneID" id="27329795"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02712"/>
    <dbReference type="HOGENOM" id="CLU_442109_0_0_1"/>
    <dbReference type="OrthoDB" id="4320670at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="85"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="555" mass="63130" checksum="D3EEAC1612005ECE" modified="2015-04-29" version="1">MVETTEAEEELPVETEIFGVSPNQTTAASLSSHIDALKRALHLASSNGTQRQCLEGSSTPVVEQRQKSQYVRNFPSIRQLKLLIGLYFEELNPFFPCIEEQEFMERMEQVRQDLVEDGGGLCLVVRPSSRNFFMLMYMVLAVATYLDSTSHSQKNAAPPGWQYCLMAEEISGRDHHTRLLPAELDLIRYYTVKAIYMVHIEKLTPASHSIAIAIQSAFSAHLNDESTWIDCSKSRKHARRLLWWTVFYVDRRIAQKCWKPYIIRENEFRVGELAVTEEELLSTVFDLQTHIKVEEQLVINRYVQTMIRWARLWAQVWDSMFAVSSSYGKNRAEEIEVLDAKILYAQRETHESLCWDTLFLPTYLATGETDAQIRSRLVAYVRFNLLRLLLRQSWKHTTAADARGSQICLELSNETIEAIVEYMVSQVNPIPFGLNAIECVVECICHLVPHVNKEKSIFSNSLPMSSFEGAIKFLENLSPKLGAARRALDALGEIAEKGWPPSFTSNGQVGGVQEIPCLINTAVDLGQGSFNELFVPDTWSEICFPSLEEGQVRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C4D2</accession>
    <name>A0A0D2C4D2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238665.1">
        <property type="nucleotide sequence ID" value="XM_016377095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C4D2"/>
    <dbReference type="STRING" id="91928.A0A0D2C4D2"/>
    <dbReference type="GeneID" id="27329820"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02737"/>
    <dbReference type="HOGENOM" id="CLU_053559_0_0_1"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="283" mass="32581" checksum="ABC35FE4182D25C1" modified="2015-04-29" version="1">MFALYLDIQKQIDIDALDETEVKGRWKSFVSRWNRGDLAEGWYDPKTLEKSQAEAASSSSAVADRYAERRTNDEQRHHDDDEDDDEDDEEDEDGYGPTLPESAKTSQGQGRMLKGGRHGATIPSLQDLRSRDEQAREDAVAARAQQRQDLNYSRALDRKLQRDRLDEIAPRAEPGTRERQLEKKREKADSNRAFASAKGGGGDMEEVRDADMMGEEDSLAEMKRMQKENERKKNERELRKEEILRARRAEREARVAGLKEKEEKTMSMLKEIVRQRFGGSTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C4T6</accession>
    <name>A0A0D2C4T6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Heat shock protein 78, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02883</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238810.1">
        <property type="nucleotide sequence ID" value="XM_016377240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C4T6"/>
    <dbReference type="STRING" id="91928.A0A0D2C4T6"/>
    <dbReference type="GeneID" id="27329966"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02883"/>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_1"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="47"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="449"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="620"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW18594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="80208" checksum="4532973FF2279E54" modified="2015-04-29" version="1">MSGEPEKAALEEYGVDLTARAKEGKLDPVIGRDGEIHRTIQILSRRTKNNPVLIGAAGTGKTAILEGLAQRIVRGDVPESIKNKRVISLDLGQLIAGAKFRGDFEERLKKVLKEVEEAQGGVILFVDELHTLLGLGKAEGSIDASNLLKPALSRGELQCCGATTLNEYRQIEKDVALARRFQPILVGEPSVQDTISILRGIKDKYEVHHGVRITDGALVAAATYSNRYITDRFLPDKAIDLVDEAASALRLQQESKPDAIQKLDREIMTIQIELESLRKETDVASKERRQKLEDTLVEKRKEVYRLTEIWDREKAEIEAIKKTKEDLEKARYDLEQARREGNFAKAGELQYATIPKLEAQLPQEGEEVKTTTKDGETLIHDSVTADDIAKVVSRTTGIPVTKLMSGEVEKLIKMEDKLREHVRGQDEALTAVANAVRMQRAGLNNENRPLASFMFLGPTGVGKTELCKQIANFLFSTESAVVRFDMSEFQEKHTVSRLIGATAGYVGYEDAGQLTEAVRRKPYAVLLFDEFEKAHRDISSLLLQVLDEGFLTDAQGHRVDFRNTLIVLTSNLGAEILMGSGANVENVTPEQRKGVMEVVQASYPPEFLNRIDEFIIFNKLSKSALRDIVDIRIKELQTRLDDRRIRLDISDKVKDWLCEKGYDPRYGARPLNRLIQQEIGRRLADRIIRGELKTGDLAKVVISKDGDTLELESSKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C597</accession>
    <name>A0A0D2C597_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238985.1">
        <property type="nucleotide sequence ID" value="XM_016377415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C597"/>
    <dbReference type="GeneID" id="27330141"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03058"/>
    <dbReference type="HOGENOM" id="CLU_020820_0_0_1"/>
    <dbReference type="OrthoDB" id="3596604at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="750" mass="82171" checksum="2788D68952A74EF1" modified="2015-04-29" version="1">MTSSRYSRLNPRIANTGLAGQLPPEEPIQFSNTINPRPSEPLPSQSSNGSLSSILNKAAKGTVTDSQAYAGSEGNLSRPPAQRQRTRSSLFRAASSVWSYSRKAVSHFSVPKVAAPWEHEFSEKSGTAPPPSDTVRYFDPRRQRRRLFVNSSFQWLMTAIICAGLAAILYGFTTFNTGVTSTTKHVFNALVTGLSICLGLSLASSLKCFAQMMRWRFLASSYRSLQDFELVMNCDSQTQTLRLLWAGRTPNQWYPNKTQVMAFLYITVNLALQVFTALLGLTYSIDISSELVRLTYGNVSIVDLSYIGNAATQDLFGDDLSSSTAQFAQFSTSNTWGITGQDYPVFFDSFDEDGTGFTQAVYRNEEFTAYWYRFVDQSPLANSLNTVTDRTVNCTAECQEHKVVAGGYAGFDSDDIDTMWDVTWVDDDGYNNTWTINDVATGATTWLANMTSCGDRCTQVYALQSADNNTDDVPVPRFFSCKSYVSQVSNVDEYVDPAKYELPDVQSQYLAGAIGWSGVQIENTDGSLASDLQMVVYPADSIWSPPGNYTELGMADLVMRFTAGAIAAMDSGAPRLNVTGYGPAPAQFLNVKWKYAGAILGGIPVAQFVILCAVVGFANKAVIKDTSHLSTARLLRPVVDRLGDAGCLLTGDEIAEKLGNYRLIYGVRNSGGAMPPSGAADDGEILHIDVVDESEGLGYRRGPMPPGRYNGLSSPEERVPLLQRRDNTERATEVRARRSTLGARARRMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C631</accession>
    <name>A0A0D2C631_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_03273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239200.1">
        <property type="nucleotide sequence ID" value="XM_016377630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C631"/>
    <dbReference type="STRING" id="91928.A0A0D2C631"/>
    <dbReference type="GeneID" id="27330356"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03273"/>
    <dbReference type="HOGENOM" id="CLU_012433_0_0_1"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018839">
        <property type="entry name" value="Tscrpt-silencing_Clr2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10383">
        <property type="entry name" value="Clr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="3">
        <location>
            <begin position="76"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic loci regulator 2 C-terminal" evidence="2">
        <location>
            <begin position="436"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW18984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="854" mass="97223" checksum="E7BBD3993DA5D44E" modified="2015-04-29" version="1">MSSTAPEQRKWHTIGKKGGPWVKVPILPFTDGQPQTWPCNTAWKGRYRPSSEERYLIQLARTWKKQQHDLVPGVDYYLDKLPEGYALFELDQLSGSQVWKRLFGHPSGNYYDSIVKFEIHFLWLMSGKQGDCRCVNCGKPLPRPVESRRPRPTEFERLVPLRRSEHNGYQSDNTSGSTSAGGSMTGRPSRRPRRHLKPAGAPYAVDEEGNEDVYKGYLRKLENSKGAKKGIEDDIREINSLDWRAEHEEFAKEEKYGVELIKQHLTLISQQHSFVPRLGELVLWTPHFLDAHYLMLDPEKREFKFFSFDQKQFHGFPRWRAGLVTQVPTTTATDGPVDFPDIQTLPDKSTSLNTSGFRVETFPDPNNEIDKTASKQYRYVPLRNIRPLSQWQMLLHGNPRSEWHHSIMSALTCMTSISLYEKWWFKGTWPSASILCKGIYIGPEFIMTGDTVRITPHAKSTAKMKKCTDVMIVDSIRLNLLNIRPEDVLPDTPLLSAASSITLVGRAYTLDIRRHYTMQNHDPNAAETVLPAPVPQEEVKTVFRPVGTGDYGTWYYLHDPTKRYEISYDRVLGRLYEAAAVKLWIGQAQFKRSGREHTVVRPSLDFDLEAIDEGRRYASETDERIEEPKPGQLGWFWADTRVEALDIQTINGIEVGKYHAARTPATLEQWRMYMRLINGHTETPDLFKYTSDYALLSELSGTGGRRGRKPGSKIVNGRVVMPGDPGYDEIAGKSLPEPNTTPKHKSSQLAGAALVSTDDEGDESDEDDIDHFEDAEEVLPSVERSSLVAATSRGSPLPRKQKTHIQSKAQIMQNPEEIDDEEEEDDDDEWLRSKPLIRGGTEESEGGDYRPGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6U1</accession>
    <name>A0A0D2C6U1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavoprotein oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239515.1">
        <property type="nucleotide sequence ID" value="XM_016377945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6U1"/>
    <dbReference type="STRING" id="91928.A0A0D2C6U1"/>
    <dbReference type="GeneID" id="27330676"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03593"/>
    <dbReference type="HOGENOM" id="CLU_020643_0_0_1"/>
    <dbReference type="OrthoDB" id="5369448at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="72555" checksum="F75F47B4E166CAB8" modified="2015-04-29" version="1">MMSSSPSAVIEDFAYQHSSPLSLRQQRLPTSPDQVSEPHDYNFSGAVYDEGTSGTDSENQTATENDEEEELLDIDRRASGCSSISSFPASVSHQVPSRTSHYGSSRTPTKRDLVGSHGVYSSEGPGYPARSPRAFPEYQSPFRHPSSVRALQMRDEVMSDTRSVLRHRRSGSQMSSYSARSSYSTPSSPAKRTTRSNRSSPQKTTSSLRKEFPLVLLHCTMLPPTLLSQAMAHEDSLICELLPEEYQKRWHHLRDKLVEDVEIKTRGILIAHPRDDYELLEERLLESLDLERPRIRHNHYFPHDSTGTDSGFESGSTTSDDNDDNGPNDTKCPDCGRKLRADETPRKWEVKVFAANGLLKAGAWGAAWQEMEKVDVEVRVWLPEDIRRDLEAKIALIDAIPGGSESNAGQSEVPTARDREVYGASGRSRSQSEIDGFFEQPAPTTMPEPRPPVPQAVPDPDDLGKLMVAAVQKFSHERRNLLVMILSGLLLLFAMRPRTSPEGQRPGLYDPSSAYMAETLTTTVTTTRIAVATATATATVTTSILAPPLPVAPGPPEDVTSSLAIKDDDSVSWEALNGTRSTMRPDGDAPVVDANISSSTSTSSNPAKPTARSEEISVETKSADSSQGENGDGDGDADEYTQTSSVVAEAETAMKELEPGSNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C741</accession>
    <name>A0A0D2C741_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetoacetate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_03679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239600.1">
        <property type="nucleotide sequence ID" value="XM_016378030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C741"/>
    <dbReference type="STRING" id="91928.A0A0D2C741"/>
    <dbReference type="GeneID" id="27330762"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03679"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="6">
        <location>
            <begin position="38"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="119"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW19384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="669" mass="73967" checksum="8702827E3303782A" modified="2015-04-29" version="1">MALATPRPIWTPNSPEKTAITAFRHYVNRRYNLNLVSYRDIHSWSVNDIQAFSEAVFDFVGIKTSEPYVRVIDGLDTMWPPPRWFPGAKLNYAENMLQPGLSSKPNGIAITTVDETGPTSSTDYTFKQLELLTAAWVAALRKLGVGVGDVVAAVLPNRIDCLVLLLATASVGAIFSSTSPDMGSKGILERYRQVRPKVFVCDTLVHYSGKKIDLRGRFSEVEKTLYREIRELQHVVIINGPLIQGSSAILASKLLNLSDPPPIQYEQLPFDHPVYILYSSGTTGLPKCIIHGAGRALIMQKKEHMLGNDIGPTSTMYQYTTTGWMMWNYSIACLSTAARVVLYDGSPLYPTPAHQVGLIRGERVTHWGTSPKFLTALKQHGLPPDMRIDSLQHVYSTGSPLSTELHEWFAANFPRNVGLFSGSGGTDLVGGIVSGSVISNIYTGEISGPNLGMKVEIWDSNGVNIEETGMDGDLVITKPFFTMPLGFWGKDGEDKYRKAYFEQYPGVWYHGDLIRKNPQTGGYQILGRSDGVLNPGGVRFGSAEIYGVLEKIPELQDFICVGQKLPPNFSDERVLLFLKLYPGKHLDEALRLHIKKAIASSLSARHVPEQIHQVQDIPYTVNGKRIENLVRDIVAGKSVGPAATAINPECLVEYKRYILPSRKGSDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y9A7</accession>
    <name>A0A0D1Y9A7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231762.1">
        <property type="nucleotide sequence ID" value="XM_016385160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y9A7"/>
    <dbReference type="STRING" id="91928.A0A0D1Y9A7"/>
    <dbReference type="GeneID" id="27337930"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10847"/>
    <dbReference type="HOGENOM" id="CLU_157438_2_0_1"/>
    <dbReference type="OrthoDB" id="5239630at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="96" mass="9915" checksum="0038CE74BCF42C3B" modified="2015-04-29" version="1">MAQGLLKKSSSKTAKPSASSKSAGVTKKGRGTITPKKAKLVKQAKINKKFTAGLTAKTEAMLGARAGHLEMLGQGRKKNAGTEQSKSSGKKTGNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCU1</accession>
    <name>A0A0D1YCU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232987.1">
        <property type="nucleotide sequence ID" value="XM_016382284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCU1"/>
    <dbReference type="STRING" id="91928.A0A0D1YCU1"/>
    <dbReference type="GeneID" id="27335041"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07958"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OrthoDB" id="1878542at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF311">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW12771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="438" mass="49083" checksum="D8DDBD87298BB252" modified="2015-04-29" version="1">MKIIIVGCGLGGLACAIACHREGLQVLLLERAPSILPVGAGIQIPPNATRIMQHFGLEDRLRQRGAVRIHSRNLLRYSDGHTLCNRPGLDDMVNDFGASYYVIHRADYQELLLEEAVRIGVDFRPNSEVSQIIFDESPKVVLRTGDEITADVIVGADVKLPSLWSTTRDQILGRSSPPQETGDLAFRGTFPLARLEKIEDDGIRDLITSQKACLWMGPDKHCSFYPVRNGQEFNLVLLTPDDLSEGIRTSQGSINELRYMFEGWDPTLLQLISCMNDSLLKWKLCHHTELESWVKGSVVLLGDACHPSLPYQAQGAAMAVEDGAVLGLLLGKFSRLNKQSANSTANVHSLLKLYESIRKSRTTTNVLGSIRNREMFHMHDGIDQRKRDEELSRVDWKTPCPWQWGDIGYQNELMGFDAVKHANVAFEKWTEKLSGDMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YE02</accession>
    <name>A0A0D1YE02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233527.1">
        <property type="nucleotide sequence ID" value="XM_016382824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YE02"/>
    <dbReference type="STRING" id="91928.A0A0D1YE02"/>
    <dbReference type="GeneID" id="27335582"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08499"/>
    <dbReference type="HOGENOM" id="CLU_035996_0_0_1"/>
    <dbReference type="OrthoDB" id="2445133at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="339"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="535" mass="58770" checksum="794F455335AB9D65" modified="2015-04-29" version="1">MFHEGDLQSGIGLALQQSKAVLCFVQDQSEASREWESVLNGESIKTAITSQAVALRIEAGSQEAGFLSPICPIDSIPAIIVIKNAQLQENIQSGQVSTDELRSRLKRAFGVKEPEQESAVHEETLQPEQRSSSDHTGYLDLQPVTEGTRITNNAYDALRNHTQKLLEDGKSPSDIFETQLNLINNIPIFRDEVKRLRTGAQGELSEHARSRLLRFPAVGLRIPGQTRSSTTPTPSQSQQTLHNGPSSQTSTIHNAKSPPVPRNDTSTSSNDPPSDERQRAQRSEYIKMQREREQHQREERDRIKAQIKADREERRRLEELRKQGDIANSSSGSSSPSKPRSTEVRVQVRTFDGSTLRSTFQPTSSLSKDVRPWVDAESNITAPYNLKLILTPLPNRSIEAAEEEQELHNLGIVGSCTLVMVPVKGYVESYTGSSTGGLLSSAVSGGYNLVSGTAGAVFGGVKSLLGYNTQETAADTSASATAGGQASTSIPQSSARNFRVRTLADQRAESARRDQQFYNGNQLNFEPKKDDDKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YIS1</accession>
    <name>A0A0D1YIS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_07621</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235052.1">
        <property type="nucleotide sequence ID" value="XM_016381950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YIS1"/>
    <dbReference type="STRING" id="91928.A0A0D1YIS1"/>
    <dbReference type="GeneID" id="27334704"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07621"/>
    <dbReference type="HOGENOM" id="CLU_003181_2_0_1"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="858"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="835"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW14836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="919" mass="101748" checksum="3315BBC5D5EA0380" modified="2015-04-29" version="1">MPKSYVSFQDPNEEDNVDYFAVHPRPATTPSSPTIYHRRSISISGPEVERRLHPSLIMTSTPDETTELLGGSMHSAMRRYADNSIISPHSRQLSRVNSFNGSLRRRRFHSALPSGQTSPVWNRKNSGLRTPKLQQSLMGSIAKDDRLWYDQFTSTDWVHDSIADGYRVLELKKKRGLRGRIQLLYDSSQGWILVALIGVITAGIAYFVDVTESAIFDLKRGFCRDAWHLGRASCCDGKRTCDQWRTWSQLIHASDVDEQSVDFAAFVIGCMVLATLSCFLTLYSKTIVPSTIASTFDEDLSAERTRNFDEGDQEAKVAAEQTHANDLAPGNVYYSAAGSGVAEVKVILSGFVLHGYLGLRVLVIKMVALILSVASGMSLGKEGPYVHIAACVGNIACRLFSKYNLNDGKRREVLSASAAAGVAVAFGSPLGGVLFSLEEVSYYFPPKTLFRTFFCCIVAALSLKFLNPYGTNKIVLFEVRYVTDWNFFELFNFALLGILGGLAGALFIKASRFWATTFRRIKFIKSHPMLEVLLVALVTGLISFWNRYTRLPVTELLLELASPCNKDSTSGLCPKEDGILSVVGYLCVAFVVKAFLTTITFGIKVPAGIYVPSMVVGGLMGRTLGHLMQYIVLKSPNFFLWGGCSQSGDLEACVTPGVYALVAAGATMCGVTRLSVTLAVILFELTGSLDHVLPFSLGVLCAKWTADAVEPLSIYDLLTDMNSYPFLDNRSSPVFDSELGDITPRLRRDKVIDITISPLVKATDLRAKLRRLQYLGELDGGLPIIRDKILVGLIPAPDLEFALDRIEDEDNAMCLLSSQNSSNTNHQRYWQAFEETGYESERESSEPDEESSATPIDMTPYIDPAPVALDTHSPMDLVYQCFVKLGLRYICVLDEGEYRGMVHKKAFVRYVKQLEHSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YLI9</accession>
    <name>A0A0D1YLI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_05946</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236112.1">
        <property type="nucleotide sequence ID" value="XM_016380285.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1YLI9"/>
    <dbReference type="GeneID" id="27333029"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05946"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1214"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1262"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1294"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1416"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="103"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="798"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW15896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1443" mass="162200" checksum="1D9154C252CEC5BF" modified="2015-04-29" version="1">METEEPESMETRQSIVGESVRDYTHADTGDSDTAAILKTDELESPLNPRSDKFNARAWATNVVKIANEHGRQFRQVGLCFENVNVVGYGTPTDFQKDVGNVWLALPGLIRRIFSRQSGQTRIDILRKFDGLLHPGEMCVVLGPPGSGCSTFLKTLSGDTNGIYLSEGSYFNYQGLSGEEMHHQHRGDAIYTAEMDVHFPQLTVGETLSFAARARCGRNLPPGAQRNQYCEHLRDVVMAMYGISHTVHTKVGDQYVRGVSGGERKRVTIAEATLANAPFQCWDNSTRGLDSANAIEFCKTLRLQSEFFGQTCVVSMYQAPQTAYEQFDKVTVLYEGRQIYFGPAPKAKEYFENLGFECPARRTTPDFLTSMTFSAERIIRPGCNPPRTAEEFAAAWKNSSEYQALQVDIREYRKQHPIGGPDAEKFRQLKKHHQASTQRLKSPYTLTYSQQVQLCIRRGFQRLRADPSLTLAMGIGNVVMALIISSLYYNLRMDTDSFYGRAVVLFIAILFNAFASMLEILTLYAQRSVVEKQSRYAFYHPSAESYASVLVDLPAKIVNCISFNIVFYFMTNLNRAPGPFFFYLLVSFLTVMAMSGVFRSIASLSRTESQAMVPASLVLLALLIFTGFVVPVDYMPKWCRWINYIDPVAYAYEALMVNEFHGRNFACSAYIPDYATVSTSYVACNAIGAIPGQAYVNGDYYIDSAYRYHHSHKWRNVGIIIAMAIFNHLVYFIASEFIKAKRSKGEVLVFRRGSISSRTTKGGNDIEMSVTGPVSTVMNSAGNLASIEKGAFQGSTSVFHWNNVCYDIKIKKETRRLLDHVDGWVKPGGLTALMGVSGAGKTTLLDCLADRRTGVGVLTGEMLVDGHLRNQSFQRKTGYAQQLDLHLETSTVREALEFSALLRQPSMTSKEDKLAYVEEVIQLLDMQGYADAVVGVLGEGLNVEQRKRLTIGVELAAKPPLLLFVDEPTSGLDSQSSWAILDLLEKLSKAGQSILCTIHQPSAMLFQRFDRLLLLQEGGQTVYFGDIGHDSTTLTGYFERNGASPCPPGANPAEWMLKTIGAAPGCSSDVGWHQTWRGSPEYRNVQDELARLREHKFERLLPIAEQRDPACESYREFAAPFSQQFVIVTRRVFQQYWRTPIYIDSKLSLCISASLFIGLVFIDSPLSIQGLQNQMFAIFELTSIVGQLVDQQLPHFTTQRSLYEVRERPAKTYSWIVFMLSQIIAEVPWNTLASVFMWALVYYPVGFYKNANAADQGAERGALMWLLFWVFMIFVSTFANLCITFADTADEGGNNANFLFMLIFFFCGVLATKDQMPGFWVFLYRVSPFNYFISAILSTGLANVDITCANNEYITLSPPRGQTCGQYMADYISRAGGYLLDANETANCKFCKIKETNVYLERIDAHYDDRWRNFGLMWGYVVFNVMATLALYWLLRIPKGKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YMK5</accession>
    <name>A0A0D1YMK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236492.1">
        <property type="nucleotide sequence ID" value="XM_016380665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YMK5"/>
    <dbReference type="STRING" id="91928.A0A0D1YMK5"/>
    <dbReference type="GeneID" id="27333410"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06327"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_1"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF6">
        <property type="entry name" value="ACYL COA SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="466"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW16276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="65526" checksum="DF543815E59C26AD" modified="2015-04-29" version="1">MASARPPSQGVPETPMSIVSGSRTHPLWEETLGELVDRHATKYGAQTAALFPWQQNHRLSYNDLASRSETIAKAMLARGLKHGDYVAIMAGNCYQYIETLLATARIGCPFVVINNTYTPKELVSALRVTSCRLFLIASTIKLKNLSTHIDEVQKELPSLPLVVIGNRSGKHDYSSFAKEGRTVTTTSLKQAESLVRNSDIMNLQFTSGTTGMPKAAMLTHRNLINNGRFVGEAMNLSSYDVVCCPPPLFHCFGLVMGFLASFIRGSTIVFPCDQFDADEVLQALYSHKCTALLGVPTMFIAEIEANKTKKLDITTVRTGLAAGSSISPILMERLEREFGVRGMLIAYGMTETSPVTFITSLDDNEEKRTTTVGRVLPHTAAKIIDREGAIVPRGVRGELCTSGYALQKGYLNNPSKTNEVMKRDEHGVLWMHTGDECIIDKDGYCSVTGRIKDIIIRGGENMFPHEIESLLATHPSIAEASVVAVPDARYGEVVGAFLRENPPQAASSGSLPDTALPQDPRSRKSSRPSWREVNNFVRNHLGSHKAPRYVFWIGDEGVGNEFPKTGSGKMMKHVLKDVAKRLVKEGKGEGGAELRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YN06</accession>
    <name>A0A0D1YN06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_06483</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236647.1">
        <property type="nucleotide sequence ID" value="XM_016380820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YN06"/>
    <dbReference type="STRING" id="91928.A0A0D1YN06"/>
    <dbReference type="GeneID" id="27333566"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06483"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000049">
        <property type="entry name" value="T-complex protein 1 subunitTheta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW16431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="548" mass="59877" checksum="C6DEAA90CAF7AF83" modified="2015-04-29" version="1">MAMQVDLSQAQLLKDETGRPFIVVRDQGKKKRTHGTDAVKQHIVAARTVASIVKTSLGPRGLDKILISPDGDIQITNDGRTIMSEMELTNPIAKLMVELSKSQDEEIGDGTTGVVVLAAALLDQAADLIDKGIHPIRIADGYDQACEVAVAQLDKISDEIPFSRERQENLIKVAKTSLGSKIVSKAHDQFAKIAVDAVMSVADLERKDVDFELIKVDGKAGGSIEDSLLVKGVIVDKDFSHPQMPSEVKDAKLAILTCAFEPPKPKTKHKLDISSVEEFKKLQQYEQNKFVEMIDMIKATGANLVICQWGFDDEANHLLLQNHLPAVRWVGGPEIELIAIATNGRIVPRFEDLSSEKLGKAGVVREMTFGTTREKMLVIEECANTRAVTVFVRGSNKMIIDEAKRSLHDALCVVRNLVRDNRVVYGGGAAEIACSLAVEDAANKSPGLEQYAMRAFADALDAVPMALAENSGLSPIETLAAVKSRQVKEQNSRLGVDCMSTGSNDMREHFVIDPLIGKRSQLLLATQLCRMVLKINNVIMSGDDDNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YN36</accession>
    <name>A0A0D1YN36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Epoxide hydrolase domain-like phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_06520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236682.1">
        <property type="nucleotide sequence ID" value="XM_016380855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YN36"/>
    <dbReference type="STRING" id="91928.A0A0D1YN36"/>
    <dbReference type="GeneID" id="27333603"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06520"/>
    <dbReference type="HOGENOM" id="CLU_045011_1_1_1"/>
    <dbReference type="OrthoDB" id="1694274at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30554" checksum="6E5E1C010B5F8149" modified="2015-04-29" version="1">MPSQSLPKVLMFDIGGVCDLFLGSDASRVLQVVSPFQAILDYEIQHGIPKGYINYSIRELTPNGAWHKLERGEIPNDANYFRMFKADLERPDLWAKFHREKHNTANPPPVPDIDAETLYWTMMSMSRSPDPYMYPALKKLKASGKFKLAALSNTTLFPEGHEFNKIGPDDVRHFFEIFVSSAHVGMRKPNRDIYEYALNEIRHRWGQDIRCEDIVFLDDIGENLKTARSLGIRTIRVFLGRTQEAVKELEKVTGLSLLDEGEPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNL5</accession>
    <name>A0A0D1YNL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236907.1">
        <property type="nucleotide sequence ID" value="XM_016378230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNL5"/>
    <dbReference type="STRING" id="91928.A0A0D1YNL5"/>
    <dbReference type="GeneID" id="27330962"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03879"/>
    <dbReference type="HOGENOM" id="CLU_046066_1_3_1"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="259" mass="28201" checksum="DCB4374DC66FBEA6" modified="2015-04-29" version="1">MSKPAIVLVPGAWHKPQHYKKVIDRLLKLSYDAVGVSLASVDANPPVPSWEKDAAAVREAVLQKLNAGKDVVAVAHSYGGLPMGEGVKGLGTKAREAQGFKTSVTRLVYMCSVPVKEGQIFQEACKPVTEEEIKAAELQMKVIKADENGNLVPGDTELGKERLYNRCDPKDVEEALKLIGSHSVGTLITPATWTPYKEIPSTYIVTENDRALLPSIQERLIAEAEGAFHVERCQEGHSPFLSDPDFIVSCIRRAAGEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNY3</accession>
    <name>A0A0D1YNY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">PV08_04036</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237062.1">
        <property type="nucleotide sequence ID" value="XM_016378385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNY3"/>
    <dbReference type="STRING" id="91928.A0A0D1YNY3"/>
    <dbReference type="GeneID" id="27331119"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04036"/>
    <dbReference type="HOGENOM" id="CLU_095765_0_0_1"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000093">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW16846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="184" mass="20358" checksum="3D8441B1DBC1EA91" modified="2015-04-29" version="1">MAALEENSHLLQPPINNYCVYHPSSPATGGLTVMVVGGPNARTDYHINTTPEFFYQHKGSMLLKTMDTSTTPHTPVDIPIHENSLYLLPANTPHNPVRFADTVGIVLEQPRPADSVDTLRWYCKNCNSIVHEASFHLTDLGTQIKEGVLAFENDMDARTCKNCGTVATSRPAEGEIQQPPRYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRE5</accession>
    <name>A0A0D1YRE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_05026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238047.1">
        <property type="nucleotide sequence ID" value="XM_016379370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRE5"/>
    <dbReference type="STRING" id="91928.A0A0D1YRE5"/>
    <dbReference type="GeneID" id="27332109"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05026"/>
    <dbReference type="HOGENOM" id="CLU_024003_4_0_1"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000227">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032005">
        <property type="entry name" value="TyrRSs_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16714">
        <property type="entry name" value="TyrRSs_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosyl-tRNA synthetase C-terminal" evidence="9">
        <location>
            <begin position="432"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW17831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="571" mass="63682" checksum="0E33CF3E34BE768D" modified="2015-04-29" version="1">MRKIQEAEEEWRTRAQDIKAGRMQSLFKTLEERGYINQTVGSKEELDELMIHRRVGVYAGIDPTAPSMHVGHMVVFMVLGWFYIHGYDTHFVLGGFTSSIGDPTGRTTGREAQSAPTRKANIAAMHAQLKRLGASIERHAERKGFQKEWAWRRSLDNNSIWWNALSARDYLAILGRNVRLGPMLGRDTVKTRLEKGDGMSYAEFSYPLVQAWDWWHLFQKGVQIQVGGGDQFGNILAGADAVKQIAKDSHEYQTALRNTKILDQKNNIDVTSEPLGITVPLLTTSSGEKFGKSAGNAIWLDPDMTPIFDLYQASTFFSPDFDADVERYLKLFTFLPLPEIRQIMEEHQKDASKRVAQHTLAREFVELIYGTESAEEAEQQHRQLFKKTLTISDITSSATDAKATSAANGAARTAPNANFMHPSLNKHAQPMRMEDNTSTRVKLPRSLVVDKPLGQIMFAAGLVSSKAEGHRLIMAGGAYVGALPGSMSKMDDNLSFAPARTNTAQEASNYIIDEKLLILRVGKWKMKIVDIISDEEYEQAGLTCAAWEAMKAAEAAAQAEAGDKETPQEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRI2</accession>
    <name>A0A0D1YRI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238082.1">
        <property type="nucleotide sequence ID" value="XM_016379405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRI2"/>
    <dbReference type="STRING" id="91928.A0A0D1YRI2"/>
    <dbReference type="GeneID" id="27332144"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05061"/>
    <dbReference type="HOGENOM" id="CLU_002406_0_0_1"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="256"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="534"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW17866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="936" mass="106254" checksum="7E293A5404541A02" modified="2015-04-29" version="1">MDIGEEVAPEASMMVDDARRYLEDTVSAQDATAIRSTTLFDLQNAARQIELNLKEVCNLRRLEYFFASLEKFSIAARAVCDTTTMAWAWGPAKLMLEICSEEPAVLKELVSAYKRIGQAFPSLGNLKDGDATSSETQQLFAICYADLLDFHRRTYEVLRRHGWYSFFQTSWARLQPWLRIYLDDLNTCGRLLRTAQSSRDIGKTRDSRNRATKELERNEEDRKVSELQNAQFWLEASTLDQEEELDVLRNKSHEDSCDWIYDNRIVESWLRNGNDHRVLWLKGIPGSGKSVLCSKLIEKIQSSQRTKVLYVLCSDSLPESKQSRSVLQSLTWQLIRGQPHLCAAVQVDFINKGHRKSSKPKIRELLHLAVSAYPSVRIIIDGLDECDLKQQEEILDEMIAVTKVDTGSSVCKVLISSQDVLKISRKLRNRTSIDLGKQQTAVRSAISSFVGAQIEQSPLFKDAESLDASELERVRQTLVTKAGGMFLWVRLVMTMLENTYTPGDLKKALEDLPEGLDQVYDKIFARFRLQLSQTNRDRASRIFQWLACSPRYLKRYEIQDAIALDFDHPTIDCDKRGFEHIVELCKPLVESGSGETIRFVHASVKEYLLKHQPLFRLEEARCNITFSCLAYLLNHGINLVAADFDDESRRVEIGQGIHGLCRYAVQNWTEHLLSYLSEKEIVQVELRAKILQALENLALALSKISQLPQSDFSQTSLDSRCDALSEHPVACTFVKSALVDQLPQRIAPAESMSATSVEHPLTSIRRKYDEISMQLLQATSVPGLQEKELESFKKTYGSDILICRTSNCPRGLQGFRSVQERDAHESTHQLRCPYLGCIYNRNGVASEKKLKDHIAASHPEERAQGPATPIKPFGEKRITTDSTLVESPANVWKEAEVVVSSDGEEEDDGDDDDVFYDKLEHVARTDGFALRSTDWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUB8</accession>
    <name>A0A0D1YUB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_03140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239067.1">
        <property type="nucleotide sequence ID" value="XM_016377497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YUB8"/>
    <dbReference type="GeneID" id="27330223"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03140"/>
    <dbReference type="HOGENOM" id="CLU_1240163_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="223" mass="25946" checksum="EEDD8602799D2493" modified="2015-04-29" version="1">MDPRSSSQRHCTACRSLKKLPNVRTERIELTGPENYTAWLRAFTFEAERKGVLGFFSSVYKGPRKPDWDRDMAEIRAHGVDLTEAELRALQTRFAFCWHAYKKDRKRFRWAKALIIKWVHPAIGEELLVRGKTPSDALDYLRKKYMPKIPCAWEIVEPERGRFTSWILRPVMVFLSEVRAHPRVEQQGAEGPLPRNPSNNTHDEFLAVSASCWMTNDDDDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YVP8</accession>
    <name>A0A0D1YVP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239577.1">
        <property type="nucleotide sequence ID" value="XM_016378007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YVP8"/>
    <dbReference type="GeneID" id="27330739"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03656"/>
    <dbReference type="HOGENOM" id="CLU_147503_1_0_1"/>
    <dbReference type="OrthoDB" id="4126315at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="127" mass="15318" checksum="F10FCFC82F8E840B" modified="2015-04-29" version="1">MAHPHLMSHQGVTHVGTIHIDPTNVDEFLEAFRACWVQVCREPECIYFDVFHSKTEPGRFHFVEIWNKDNDWFMEVQIKKDYYKPYWDITRPLWEARDLHTYDRLSGFNFVDGRYLEGSVKVKEELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YX10</accession>
    <name>A0A0D1YX10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240057.1">
        <property type="nucleotide sequence ID" value="XM_016374781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YX10"/>
    <dbReference type="GeneID" id="27327499"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00416"/>
    <dbReference type="HOGENOM" id="CLU_024800_0_0_1"/>
    <dbReference type="OrthoDB" id="4115389at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="1">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="699" mass="80146" checksum="CD7610DE74BB31B9" modified="2015-04-29" version="1">MSSSRSLYHPKDAWDYWRETIDHMYLHENKTCGDIRAYLISNDFSCSERQIKNRLREWKYESKKTPSQHYLAMLSYANSERVDGYKIKFDVPKRDGRVYFSLKKIKKECDRVKKKYENAHVEFSLPSYEVAERILWDADIRISRHLAEPDDLTRSKSYPEIPGEPDGHGCYAPGRPFANYTDWTASIDNDSQVSQGELDEEYNFARLETNWASHSLLGNQISTVQIDHPNIITLNGEPLACSSPTSVVMKDFHDSQWSTCEDNDPSWKLNNLSAQTISVICAERSAALSHAVPTLTHCSDQLRFLLAILDTRILLPRIRAYLRMEESVNSFLNSETLSILMEEGYYSNSDSGECSTSLEEEFLGHRIDVDRLDISNLSPPLKALVKGIKAKNDEAGVIRLRYGLCELSDWILPGLVWMHLVLESDGRDAELKNFLSIGYTILEQAEHLEDHTAFAVPFRYIFAEFTRNSGDTAKWGQRLRGAHARITSRWGIDHPNSLAIATYMAWNDLHHGRLESAIQLLTAYVDICERRLGPHSILTVAGWALMSRALDEHGNLVGACASVAKVVERFDSDRSDLGKYRLMMMHRFGELLLRTDQLEAAETYLLEALGGRLQVCGLESGEVWSTIRALDAVFLRSGRIQQAQEFVEYFTNLFNWEQRREWAKENNVELPFPFPPSWLPDQIIVDIIKMRPKKRSTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YYQ9</accession>
    <name>A0A0D1YYQ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240642.1">
        <property type="nucleotide sequence ID" value="XM_016375366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YYQ9"/>
    <dbReference type="STRING" id="91928.A0A0D1YYQ9"/>
    <dbReference type="GeneID" id="27328084"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01001"/>
    <dbReference type="HOGENOM" id="CLU_622611_0_0_1"/>
    <dbReference type="OrthoDB" id="4464164at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW20426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="49194" checksum="119111DFFFA49980" modified="2015-04-29" version="1">MASPTSTSTTLIHVKKESAVLDSHGLPPREPRDESGKERQKNFRELSTEQKLLAIVRYSVKPFSDRLDPFAALPVNLDRLQEHLISFYLLYYPKATYGFSPRLRPHPVASNFSIALTTPACFQVILARSALYRIGLNKYASDSEKDQLNMAVMRHKGEALKMLRVLSAKAAPNRKDDLLASIISLGTFDRRNGAKDAAGMHYSAVRRILKSTGGPLAVNSVLLSRVMCFFECIYGTSPESYIWDESGLDRLVNGLNGFLGDIWELWKSLSTISGLTAQTTKAPGPPRIHSFGLQPDSSLLALVERQPPSDAELTQQRRLEMIFQVTCLLTFGMITLDKAGDFRSLQQYMDGIHKQVEDLHLMGQSCNNIMWQIQVNDHSADHSRRIWRAASYAWVLKHVSYDVQLKVKEWLLAFFQGEPVAEKPFRLDPFHFSYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YZ65</accession>
    <name>A0A0D1YZ65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_01131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240772.1">
        <property type="nucleotide sequence ID" value="XM_016375496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YZ65"/>
    <dbReference type="STRING" id="91928.A0A0D1YZ65"/>
    <dbReference type="GeneID" id="27328214"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01131"/>
    <dbReference type="HOGENOM" id="CLU_026522_0_0_1"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF125">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YLR001C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013379991" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="146"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="287"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW20556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="493" mass="54506" checksum="575A3663100AB5D2" modified="2015-04-29" version="1">MRVLSVLSTAALASAFVIPDQTTLESLSLENQEVEQAPEHPFWDKAHKAETFWEDLEGEFQKAAHCAKHKFEEVVESTEAAAVKYSERFENAFAGDAWLDSAEHDLDLDLLEHPPPHGPPHRGPGKPGKKPKKPKKPHHPHHGPPNETVYQLISKSKYTTKLAAVIDEFPDLVELLNGTKANYTLFAPTDHAFEKIPKHAKPPKEFLKKLLTYHISEEFYPAGRVLVSRTIPTALQAEYIGDVPQRISTQVSLRGLTLNFYARVVAIDIFGTNGVIHGLDSFLLPPPKTVDILSALPGEFSTLDLALEKTGLYSAFNDTSSHKGGTLFAPSNLAFKRLGPKVNAFLFSRFGLKYLKALLLYHAADDITLYSDAIYKLDSESHPPHHRVPKGFVHVDLPTGLEGKSLSIDIARYGRLITVKINGFTRVSVLDGIAADGVIHVVPVVLIPPKTPGGPSVAEDNMDLEEFKARLAPFVEEEEPRHVSFFIAESPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAD3</accession>
    <name>A0A0D1ZAD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230173.1">
        <property type="nucleotide sequence ID" value="XM_016386041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAD3"/>
    <dbReference type="GeneID" id="27338816"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11733"/>
    <dbReference type="HOGENOM" id="CLU_408838_0_0_1"/>
    <dbReference type="OrthoDB" id="4161467at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="76115" checksum="06D59CC8D2C50EF9" modified="2015-04-29" version="1">MASRPAAPPSRATAAPPGAVVAPLMSFAATRQAAPAEVIRALKESHQLDKIPFDVRMKGIIRDKVFPGTVCKECRLPHPTCYHGKGYYEAFKPCGSGSKELHCTQCGGRGHTVNECGKGEWRDFPDNPPLQHSHRTHFRPWPREYDWVPFPRHYYRPDLYPKADPMHPDLPKPIAQTGFEWGLAKAKWGLKYSIDTEYAFSRGLRPTKFDLKTVREWLPFAAIQEPLSAPVREPEARKEPPADSKVAKEKVLPNPEPKSEKKISSDATNAADPNEGYGGVTHHSSLPNPNHTEKNKGDLSPAWYKALAPMLPMEELRYSETLRGNLDAAIKQHEKGGSARTLNVLLAARQEVFDLYKIYMPHWSPARKKSFGDLPNKVKVVICSRIEERKEKAFQPPPPRKLDLQYERTRGQHGEPRFEEFVRSSGQEEPEEEELGDWADDDDFGGAGAATTTQDRRHPQIMPRSDEEADVHIKGLMDHVFSEFVLNRVVIRKYEDFIGKTLEDLNEKASQFATVLKANESKSEEKDRIVAKTREFLNAIKKLPTRWIGEVDQLIVVIKIQCNELGDDTERGMKNFTALQQALQKAFDDFERNMADHLSKCFSIEGVSEPFLSWLSSSCMEDPEVIAGIQGAFLPDESQPRAQLPRFTWPEYFLLEVIKKVAEPENDSKNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZC59</accession>
    <name>A0A0D1ZC59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_11556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230808.1">
        <property type="nucleotide sequence ID" value="XM_016385864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZC59"/>
    <dbReference type="GeneID" id="27338639"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11556"/>
    <dbReference type="HOGENOM" id="CLU_013756_2_1_1"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="37"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW10592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="504" mass="56018" checksum="CD41EBF8B814D585" modified="2015-04-29" version="1">MAMFEDEPRQQSTESQPLLQEQTPHRTAQPPRVSRAVFWKLYALVFCVNIAFQLLIPAQTEIFENIYCKQWYRRHPRPDLPAHRPVPESFCKISPIQTQVSSLKGWLEVSQAVPGLLLSIPVGVLADRIGRRHILIANALSILLMQVWITAVTWFDGRFPLQTVWLAGTLGLFTGGSMVTEMLFICILSDISPHDRLADTFVFTTSFSYIGRMLGPLVSGILMRWSPWYPVYLGLGVLGVTIFVVVSLPETLHLQKREDTATEETSSERDERTTTTPPPPPNNRSSFTASRTSIRKVLKIWSDWRLVVVALTLPLKIIFYALNDLVQRYVSDRYGWTLANATLLYSLQAATTTAMLLTVLPLISNYIDSRFSISVLQKNVVLTRASLFVLALAYAIIGLAPNPAIMLIGMFVETLSTGLPATMRALAAALVSSQDKGSVFSVMAVAETLSTMMAYPVTAMLFNIGLEHGGGVWLGLPYDFVSVAAALACIIMCLLRFERRVGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZD10</accession>
    <name>A0A0D1ZD10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_10191</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231108.1">
        <property type="nucleotide sequence ID" value="XM_016384506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZD10"/>
    <dbReference type="STRING" id="91928.A0A0D1ZD10"/>
    <dbReference type="GeneID" id="27337274"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10191"/>
    <dbReference type="HOGENOM" id="CLU_026207_2_0_1"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="112"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW10892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="414" mass="45738" checksum="2D88495A1AC13356" modified="2015-04-29" version="1">MANSVSPYTIDNLPYGVISTKDKPKKRCAVAFEDSAIDIDLLYHEGFFSSIAELKDNVFAHGNWNAFAVLPAGVRTAFRGLLKSGIADGSVQKAMVPLASVQNHLPMHIHNFSDFYCSLEHTKNCSDVFNLTIQPNWFKMPSVYNGRTSSLAVSGTPFHRPCGMYPDSRGSDQISFKPESHMDYELEMGVWLSRPVPKGQRVKIANAHDHIFGLTLLNDWSARQIQGFEMPPLGPFHSKGSCTTVSSWIVPIEALEPVRCERKTKQEPAPPPHLTWQEDDKATFDIDLNLTLLRDGTSYTLCESNLNELHWTPYQQIAHLSAAGEGLSPGDVFGTGTISSPRTNADGERIGLGCLFERNLPNARLKSMPSDLVDTFLKDGDEIILQGWCKDKASGKVILGFGECRGKILPAIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZE21</accession>
    <name>A0A0D1ZE21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231478.1">
        <property type="nucleotide sequence ID" value="XM_016384876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZE21"/>
    <dbReference type="STRING" id="91928.A0A0D1ZE21"/>
    <dbReference type="GeneID" id="27337645"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10562"/>
    <dbReference type="HOGENOM" id="CLU_1004848_0_0_1"/>
    <dbReference type="OrthoDB" id="10553653at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="277" mass="31278" checksum="215DD0B58C77B542" modified="2015-04-29" version="1">MKIRYRRHKSFTKQLARFIQRQEDEEDGADLGVGWVQLWVEQTPSAPEARQPWYSHETQTTLDKNWYEDPDGTGVAPNTIRFVPRKPTRDPSFPASIFRPLHPQDRNPFPGIPLCPQTLRMLEQRSEVLFECTLLELTFDKEETKQLLSQNFTTVKNQWKAKTKELERQPGYTPVPPPLNQAISSSIPHIGGQEDKDRVKSPWPWSRNTKSGVNDSTAPRGNAGPEVAGGTNAGTPAPTAWRPEPYRGGGRGGAQSRKKPRATRPALELQPPVREEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZFX2</accession>
    <name>A0A0D1ZFX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_09155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232098.1">
        <property type="nucleotide sequence ID" value="XM_016383475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZFX2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZFX2"/>
    <dbReference type="MEROPS" id="C12.002"/>
    <dbReference type="GeneID" id="27336238"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09155"/>
    <dbReference type="HOGENOM" id="CLU_054406_0_2_1"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="12"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW11882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="249" mass="27223" checksum="7CABE197342AE967" modified="2015-04-29" version="1">MADVDVPAGRKAFVPLENNPEVMTHLVRQLGLSPTLEFHDVYSLTEPSLLEFLPRPAVALLLVFPVTQNYEKFRVAEDASRPEYAGSGPDEEVVWFKQTIRNACGLIGLLHAVTNGAARDQITPGSDLDTLLQQAIPLKPVERADLLYNSEALESAHATAAAKGDTTAPDAEDTVDLHFVAFVKDKNGELWELDGRRKGPIKRGHLDPQDDVLSEKGQELGVHAFLKREEEAGGGEMRFSVVMLGPSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZHT4</accession>
    <name>A0A0D1ZHT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232678.1">
        <property type="nucleotide sequence ID" value="XM_016384055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZHT4"/>
    <dbReference type="STRING" id="91928.A0A0D1ZHT4"/>
    <dbReference type="GeneID" id="27336822"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09739"/>
    <dbReference type="HOGENOM" id="CLU_010412_5_1_1"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="81" mass="9145" checksum="8C561BB1F6D1BADF" modified="2015-04-29" version="1">MGKVHGSLARAGKVKSQTPKVEPQEKKKTPKGRAKKRITYTRRFVNVTMTGGKRKVGHVAFNRIAARKIYTDAYQKFADEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJ59</accession>
    <name>A0A0D1ZJ59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233103.1">
        <property type="nucleotide sequence ID" value="XM_016382400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZJ59"/>
    <dbReference type="STRING" id="91928.A0A0D1ZJ59"/>
    <dbReference type="GeneID" id="27335157"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08074"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="305" mass="33738" checksum="2388CE2AE2EECFC1" modified="2015-04-29" version="1">MRRLGSANGKKKHFKSRIKQRTMSELVWLITGCSSGFGEQFVHSVLARGDKVIATARKIDKIQHLQQAGATILQLDITDKQQQIRDTIAAAIKVHGRIDVLVNNAAYIAIGTWEDLEYEDFLAEFDTNVFGTIKVTRALLPHFRERRSGTMVFIGSLSGWVGHAGCGAYAGSKFALEGLVESLSRETAHLGFKTLLIEPGRFRTKLLSSGNMKSVASAIPDYQEFSQNLLNGLSQSDQTQPGDPVKLAEIILDLVRQEGVAASRNVPLRIPLGVDCFEELKAKCEETLELLKEWEATIKSTNHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZMV3</accession>
    <name>A0A0D1ZMV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234368.1">
        <property type="nucleotide sequence ID" value="XM_016381266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZMV3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZMV3"/>
    <dbReference type="GeneID" id="27334016"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06933"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_1_1"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF11">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="310" mass="33632" checksum="9A3816B09FC4D041" modified="2015-04-29" version="1">MAKTLAVFGATGTQGGSVVSNVLSDPELSQKYKLRAISRDPNSSKAQALKEQQVEVVTGDTSDLASIEHALTGVDFVFLMSTPSWGPNALENEFNIIKSIADIAVRKGVEYIIFSTLPSCSKMSQGKYTAVTAFDAKAQGEEYIKTLPIKSAFWCGGFFMENFVTQPFLGPKPNDDGTFTLARNAPATLKLPYIDATDDAGKFVNAILAEPDKYVGQTFCAAAGFYSLAEIATLLSKSSGKQVTFKQVSYDEFKASLPFMGDLFAQGFACQAEYGYFGHGGEDKVSWATKNIHGKLTTLPEYFEKHPFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZNH8</accession>
    <name>A0A0D1ZNH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_07174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234608.1">
        <property type="nucleotide sequence ID" value="XM_016381506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZNH8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZNH8"/>
    <dbReference type="GeneID" id="27334257"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07174"/>
    <dbReference type="HOGENOM" id="CLU_134511_0_0_1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW14392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="139" mass="15434" checksum="AD5C793A01E2CEEE" modified="2015-04-29" version="1">MQPKLSIIVYRGDPVGLRTTRHTAPFITAGKGATGIVLHVTGAAGFFGFEQRQEDDPRGSRHFTKQIPVEPLRDVTKQQLMSTTAGTPIDNRTQSWNCQHWVAEGLTRIANQRWIGMRTKSGAIGEMVDVIMEAEDEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZPQ3</accession>
    <name>A0A0D1ZPQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_07582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235013.1">
        <property type="nucleotide sequence ID" value="XM_016381911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZPQ3"/>
    <dbReference type="STRING" id="91928.A0A0D1ZPQ3"/>
    <dbReference type="GeneID" id="27334665"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07582"/>
    <dbReference type="HOGENOM" id="CLU_027084_1_0_1"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000925">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW14797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="481" mass="53069" checksum="A6FB543C247AD0F4" modified="2015-04-29" version="1">MMQNSNQRFSFPSFQKPQSEAAYQQALRQRLPYPAKGGMEIGGLLNARNAAAADAELRRQIQQSMQMEGGVAYAMSQAPNMAHHQPHHMQAPGMPYLGQPQHSHQLYAQSYIPRHDAQTMVDDNFGAIRQKNESAPKAFACSTCQKGFARRSDLARHERIHSGIRPHACDFPGCGKQFIQRSALTVHMRVHTGEKPHMCERCGKPFSDSSSLARHRRIHSGKRPYKCPYANCQKTFTRRTTLTRHQNHHTGTIEQAAAETNAKLSTTQGQSQSMYGSASGSSRHSTASPADRTLSVSPNAELPPATNGLQRQRSDYGYLGQNHSIPPHLRPDFQQNPTRSAPTMNVQPIHTFTSAPQQRPTTARPQTFGPPQPMEPPASGTGGGTGSGNASPHMGNLGWNAQNPGTLPTSAAMDNYAYPDPGYGGHPLYYPGSSIRRPQSTEPEEYGIRPRQHMGHHMPVGPDWGTMPMAVQDSRQERYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZRW1</accession>
    <name>A0A0D1ZRW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235713.1">
        <property type="nucleotide sequence ID" value="XM_016379886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZRW1"/>
    <dbReference type="STRING" id="91928.A0A0D1ZRW1"/>
    <dbReference type="GeneID" id="27332626"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05543"/>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF40">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G09800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="66"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="304" mass="33212" checksum="8011B3C78599351F" modified="2015-04-29" version="1">MAPSAISDLLPSGPLASKSVKPADQIQHVHGLEDTRPIQAISHGDVALPGVPTFTDMAAKRQWQLEHMAAAFRHWAREGYVEGISGHISVRDPEHEDVFWTNPLGVHFGLMKASDMIAVNFDGKVVGGNRTRPPNHAGFLIHSEVHKARPDVHAVCHAHTVYGKAWSVFGKPLEMLTQDSCKFYKAHSVYNSFGGVVLASEEGAQIAKALGPTNKAAILRNHGLLTVGKTVDEAAFLFLSMEHACQGQLLAEAASQGGNIPKVLIDEEEAAYTAKMESDPDTSYAEFQVYYDWEDYHSKGDFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZST8</accession>
    <name>A0A0D1ZST8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_05922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236088.1">
        <property type="nucleotide sequence ID" value="XM_016380261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZST8"/>
    <dbReference type="STRING" id="91928.A0A0D1ZST8"/>
    <dbReference type="GeneID" id="27333005"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05922"/>
    <dbReference type="HOGENOM" id="CLU_101052_0_0_1"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW15872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="203" mass="22140" checksum="7F0E51C626FB6BA1" modified="2015-04-29" version="1">MKPTNTSFRVVTFAPRAYLFTSCTRTTAVSSRTFSASSASRNDSSSSSSKPAPSPFGFGGGPSPPRLPKEEQEIFEALQRSSTGAFSTPRTPPKINQSPHSEPAEAADAQVRVEERVDRIQAQSATRQKDLGESMSRFKEQFDRKIDARGDGEELHPNVVRGAQPEFEGDVNPKTGEVGGPKNEPLRWGASGEWSYNGRTTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZWB3</accession>
    <name>A0A0D1ZWB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_04153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237178.1">
        <property type="nucleotide sequence ID" value="XM_016378501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZWB3"/>
    <dbReference type="GeneID" id="27331236"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04153"/>
    <dbReference type="HOGENOM" id="CLU_1959595_0_0_1"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="130" mass="15006" checksum="2E3271DA12148338" modified="2015-04-29" version="1">MDPHTKELVYLGIHPEQLRLEPYYFLKYSVAKTVKAYWEAHKQLAKRQSIPPPPLRRVGNLPPSSGHNRNLEVANILDYHSFAYERHELFSCGNPTCQQHMRCGMGAMPKRRNKAWQILSLDGFKSSTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0S5</accession>
    <name>A0A0D2A0S5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238778.1">
        <property type="nucleotide sequence ID" value="XM_016377208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0S5"/>
    <dbReference type="STRING" id="91928.A0A0D2A0S5"/>
    <dbReference type="GeneID" id="27329933"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02850"/>
    <dbReference type="HOGENOM" id="CLU_052998_0_0_1"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="467" mass="49900" checksum="E4B7516FEABBFB12" modified="2015-04-29" version="1">MPRLEEQGSSNGRGGGRGGGGGAGKKSHHHHHNKNGSLPREVLVSKALSRLLRHAAAQERIPIDNHGYVRMDHLLAWQKLKSMQPRVTFEEVVNVVLNNEKRRFALKYVGDDLDREPERALQEQEQEQGQRQGRPDHDADTETEAETETQRAVSQYDNLKRANGGQLPDDTAHALQRFFIRATQGHSMAAVEAENLLTPITLDDPSSVPETVVHGTFYGAWDAILVSGGLKKMSRNHVHFATGPSFQDVMERVGATTVGHGGATEDTPADGIDGHSTSTSDKGKGKGIGKEGGESAASRELNQVLGKNKVISGMRSDAQILVYVDIRRALAERPEMKWWRSENGVVLTDGVGVAVSNSTAAAIKNTRDSKEATDGGGDGDDRDGNGMGNEQHGGPQDHDNKVVPTIFFSAAVEIKNGIGLLYESGRGVVNQLPEQLRSRGVPRGKGRGGRGGGGGGGGGGGGRARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A0T3</accession>
    <name>A0A0D2A0T3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_02860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238788.1">
        <property type="nucleotide sequence ID" value="XM_016377218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A0T3"/>
    <dbReference type="STRING" id="91928.A0A0D2A0T3"/>
    <dbReference type="GeneID" id="27329943"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02860"/>
    <dbReference type="HOGENOM" id="CLU_014095_3_1_1"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW18572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="670" mass="74972" checksum="3563DFFD04CC3562" modified="2015-04-29" version="1">MDATAPQQQPLIPSTETPNAQKVDNGQIDRVLRQKRKQHESRSCVPCKRRKVRCDNNKPCTTCKKRGHPEICVYEASRPSRRATPVQRSVYNTEIPAHPLRLSTAPAALGAPEPHLEGTNRHSSPSEAYSIASIAQAKAQQTDGEELARDVGSVLGLQNSLASYPFMDLASSTERWCGLLQVIPHRQEILSLFPIFQMRVFPFNPLLVDMDQFELDVHAYLRAYTAGEFKSTTISKEWGNEQAIGLISLILAVLSNAAHFSDLVGPDRSRVCYDLARRSFQALRLANFLFRPTQENVQTMLVLGNMLQNTGQSDAAWASLGTTARLAQTLHFHARGNRMNIPETVKLKARTCWSNIIWQDTLLSMCHARRPLAIINAPVHVDLDCEGSELTYYGFMHALCRISIAVLNNGSPDVDGVTTMLEQLDTLHRKTKRYLEDHDQCRSSLERLQHLALKMHKCFLVTFLCRPEIRNANRSLNHPPITLSQKQLRLRERAENNLIEATKTFLEFSAVSTVPLRSWSMVHTALSSVLLLCIWEETRVKPECRYLREKVIEAFSSPESNNADDLASADGVTQWLSSRHIHALVTLKDAFTAGDSGLQVDYNALQGWNSADLGQSGFVPDLDADWDPFADYANGFDQSVPYDPGATDMGLPAMEMSPTNYLNYIMGGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A1U8</accession>
    <name>A0A0D2A1U8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239128.1">
        <property type="nucleotide sequence ID" value="XM_016377558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A1U8"/>
    <dbReference type="GeneID" id="27330284"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03201"/>
    <dbReference type="HOGENOM" id="CLU_029457_0_0_1"/>
    <dbReference type="OrthoDB" id="4141606at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="545" mass="61997" checksum="957C539902D69755" modified="2015-04-29" version="1">MAPRVNWPLPAEKFVLDWIEDNKGPGGKLLQDGESAIQELAENDDFLQLVPMLQRCTPPERLLKITEKLKRMYDEFRLPQYQEPLTTIYKYGVKIFNWDTLGKRYATLYTPEEIETRIQLTTSGTASPPTETSSTPQPGSKRKSPDAETDDRTSKHFRPCNTGTDDGDGHAVIDKTREIPPQSEPVLRREISSDQQRPARTLPALPALQPFDLRNFSTIRPKSKTANLPKATELLERGYERLSSHGAIDGQLREIYDKITEAVKDLVEGSEIGKDQPICFEPESAYPDKLARLMMAVLGYPGDSVRARHVLYQRLQQHKIIGWHVFIRSLLAAAVTRWCLDAGQTKSDAMGEQSIYQSYGNGVVQKVLENFLDPELELVIREKLLVAYIDQNIIPKIQSRAEDMAFRFQTFVELLLPRLATRAQLSRGTEDIIEFPEPESDHPAAFKQSPVQANFDQALISIFKDALHWRAGKDKITRERYTFVFPSMGASYVSEDMFSQKDKDGNRLTAPIVVCLWPIAYRSTRSARDPRNFEDRLRVSKGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A405</accession>
    <name>A0A0D2A405_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C45 hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239798.1">
        <property type="nucleotide sequence ID" value="XM_016374522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A405"/>
    <dbReference type="STRING" id="91928.A0A0D2A405"/>
    <dbReference type="GeneID" id="27327238"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00155"/>
    <dbReference type="HOGENOM" id="CLU_037787_1_0_1"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="108"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="349" mass="38669" checksum="C59E5F5AC901294B" modified="2015-04-29" version="1">MLEVHCVGSPFEIQIGLEHGTKAKSQIQSTIAFYTGLFQRKCNLTWQAACTEAERFAAHIHEQYPHLENEMQGIAKGAETGYNEILALNVRSELFFGAALDGCTSLSWKTDEASFVAQNWDWMEEQKENLVLLQIDQVGKPSIQMLTEAGMIGKIGLNSAGLGLCVNAIRCPGNDATRTPIHIMWRIVLECTSLDSALEAIDATGCASACHMLIADPSGSIGVEVTHQTIVRLEPDSKGRFFHSNHMLETHPGTEMLWVEDSLSRVERIRQLADQMQGDVTKESIQALLRDEDNYPCSINRAQKGESDAASVFSISMNLTTAEARVLLGRPSDPERMFLLRPRQVSYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7H4</accession>
    <name>A0A0D2A7H4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_01304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240943.1">
        <property type="nucleotide sequence ID" value="XM_016375667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A7H4"/>
    <dbReference type="GeneID" id="27328387"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01304"/>
    <dbReference type="HOGENOM" id="CLU_076637_0_0_1"/>
    <dbReference type="OrthoDB" id="4135563at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW20727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27421" checksum="20259C25BF8A86FF" modified="2015-04-29" version="1">MALWTGFPAGVGLPPQSDLVPTIRKPLKCRAKSEDFERKLSTRFAVSDQILSDADEEADGDPLLLKMPFEILLAIYDSLEHSPSQIALALTCKRMAIVARDVHLHLSPTSPKYAGFLPKTVFDVPELMAQLKPWMPADLRLCNHCLTNRPRDEKYWNGIVGCEISNFWIQKTGWNFHDASWHKQVHDICPACHVNCTLSDYVDCDGCRALGRLGDIDWTRVSDSWRRRTEAELQAGRFATGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A7J8</accession>
    <name>A0A0D2A7J8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_01340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240978.1">
        <property type="nucleotide sequence ID" value="XM_016375702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A7J8"/>
    <dbReference type="STRING" id="91928.A0A0D2A7J8"/>
    <dbReference type="GeneID" id="27328423"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01340"/>
    <dbReference type="HOGENOM" id="CLU_1142610_0_0_1"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:DNA binding"/>
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    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
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    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
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        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="7">
        <location>
            <begin position="151"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW20762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="243" mass="26970" checksum="881E19D41D4128D6" modified="2015-04-29" version="1">MDNSSTPADLNAQPNMNAARTISASPSRRRRRGSLADPLRNSKHDNNNNDRGKENSATVKTTLTVNIETINEPVTPGPPSPKPGDTYPGSGKGGIPQDGLAWKNHISNKRYHNPGVNHNEINNQESTEAFILGDGEKKIEEKIDTRTPNTVIFTFNKEDHTLANMLRAKLLENSHVTFAAYKVPHPLFAKFELRIQTDGEITPKEALIASSKEIIRELDVLKHRFKKEYDLRKMVGSVGQNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2A8S1</accession>
    <name>A0A0D2A8S1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PV08_01757</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241393.1">
        <property type="nucleotide sequence ID" value="XM_016376117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2A8S1"/>
    <dbReference type="STRING" id="91928.A0A0D2A8S1"/>
    <dbReference type="GeneID" id="27328840"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01757"/>
    <dbReference type="HOGENOM" id="CLU_001832_2_4_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
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    </dbReference>
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        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="258"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="577"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="758"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1211"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KIW21177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1231" mass="139166" checksum="42AC3E5A85AEFAFA" modified="2015-04-29" version="1">MDDFTSLELLSLVSKVTSELQNHLGINDKTLAEFVIDQHEKCGGNLPEFKAALAAMGAEFPNSLVESVDRLILTMHPKHKTQKKTQENGRSDMDELDAIGRKARVFKGLAVPDREQAWDDYEDDMVGQKTIDESRPPDPGTPADDDDTFALLEGLAGKAGNGTNGNSTRSRKRSRSPDRDEYARDRKPRQKYMSRSPSPQEERRSRHRRDRDRDYDDRRDRYDERRNGHRKSRRRDYEDDDDFKKPPRKEIDEYPVLYKIYDATINGIKDFGAFADLQGVKGRVSGLIHVSAIQEGARVNHPSDLLSRGQPVKVKVIKMENNKVSLSMKEVDQVTGQDLVPSRRIASGANMERLDGMPSEDRYGGLGSTVPVIEDDYNSNSRKNRKRLTSPERWEIKQLIASGAISAQDYPDIDEDYNATLNGQGPVDEEEEDIDIEVREEEPPFLAGQTKQSLELSPIRVVKAPEGSLNRAAQAGTTLAKERRELKQQEAADKAAEEASKVDLNAQWQDPMINPEQRKFASELRQAQQQTSKATDAVPEWRRVTQGKNQSLGRRTDMTIKQQRESLPVYKFRKQLLDAIAQNQLLIVVGDTGSGKTTQVTQYLAEAGYANNGIIGCTQPRRVAAMSVAKRVSEEVGCELGREVGYTIRFEDRTSPETRIKYMTDGMLQREILLDPDLKRYSVIMLDEAHERTIATDVLFGLLKKTLKRRPDMKLIVTSATLDAEKFSEFFNKCPIFTIPGRTFPVEIMYSREPEEDYLDAALTTVMQIHLTEPPGDILLFLTGQEEIDTSCEVLYERMKALGPSVPELIILPVYSALPSEMQSRIFDPAPPGSRKVVIATNIAETSITIDHIYYVIDPGFVKQNAYDPKLGMDSLVVTPISQAQAKQRAGRAGRTGPGKCFRLYTEAAYQSEMLPTSIPEIQRQNLSNTILMLKAMGINDLLHFDFMDPPPTNTMLTALEELYALSALDDEGLLTRLGRKMADFPMEPSLSKALIASEDMGCSEEMLTIVAMLSVQTVFYRPKEKQQQADQKKAKFHDPHGDHLTLLNVYNAWKQSRYSDPWCFENFIQKRQIARARDVRQQLVSIMERYKHHIVSCGRNTLKVRQALCSGFFRNSARKDPQEGYKTLIEGTPVYMHPSSSLFGKPAEHVIFHTLVLTTKEYMHCTTVIEPKWLVEAAPTFFKVAPTDRLSKRKKAERIQPLHNKYAGDDDWRLSAQKRQGRGGGGGTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ASP4</accession>
    <name>A0A0D2ASP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_12027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847503">
        <property type="protein sequence ID" value="KIW09743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229959.1">
        <property type="nucleotide sequence ID" value="XM_016386334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ASP4"/>
    <dbReference type="STRING" id="91928.A0A0D2ASP4"/>
    <dbReference type="GeneID" id="27339110"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12027"/>
    <dbReference type="HOGENOM" id="CLU_096862_0_0_1"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="88"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW09743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="251" mass="29105" checksum="D5EB2FB7D3FE31DA" modified="2015-04-29" version="1">MANCTDSNILKTAPKGNDYTCNDGSTVTLSTRPNLRSRLIEVLLQRSKHETRTSLAGQPLIIGNDMDQQEHQRSPTEKSRPKGQWEKFQVEYIKRSKYDLDRQEVLYEIKWLGYRDAENTWEPRENLLPDCLINLFVHHYLIGSTPLPFHKPPRYTTRQPPTQPTNEPSGLVERIINNDNFSLHVDWMSQVLQTDWEQEVVEVEDLHFSSSGEPVAVANTSNGQRHILTTEWLALHCPLKMLRFYETNGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ATS3</accession>
    <name>A0A0D2ATS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_11681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847501">
        <property type="protein sequence ID" value="KIW09905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230121.1">
        <property type="nucleotide sequence ID" value="XM_016385989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ATS3"/>
    <dbReference type="STRING" id="91928.A0A0D2ATS3"/>
    <dbReference type="GeneID" id="27338764"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11681"/>
    <dbReference type="HOGENOM" id="CLU_029208_0_0_1"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF25">
        <property type="entry name" value="TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW09905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="616" mass="69253" checksum="62CC957054634198" modified="2015-04-29" version="1">MAPSRSEIRRTPQACRTCRRRKTKCNGVHPRCNYCSAKDIMCEWPPNVINAFAGGDTSTIPSWHLSLDDPSLRTATNTLPLSSEGLKLCMALFFEKHSAIDFCSFFRQSQFDGTKPQNHFLVTAIISLVIRYLTEDEVNSFFGFSSQVEAYRHFTKRAQCLARESSDHPSVPNIQGNLVLCLSALLSDLGLSHWMYAGTAIRMAQAMRLNKEYHDKHSEHEREIRRRTFWACLQFDRLLAFFLTKPHTLSLKNVAIALPSTDVSFAYGDPTRGVTLLTLAEYTGSASDLGLVPYLLKCLSLWSDMADFHVSHGRRSEPLPPTDTFSRFSLLSASVKDWAAALPTRLHWSEENYKVHSALGQGPTFIALHCLLLSAWCVAHQEYLPQTDGSSILLDYSDAAGWSFLHREPSLVSTCVSNALAIGELITETFSRQSRPEPPVSAGGIFVALAMFSAASPLLWLQYTADPQEFELDKGRAMEYFETFRQLLVGWRHHSWKIAGVWLKGLDEMRALYEYAYRGDPSILPSTLDNMDTEEGTENPGGEEPWSSYRPQLGDGLPQLDWPTNLYSFLCFNSVSMGSLPSEKQRYIWAVLTRGWPYSTEDSAFLDFSGSMALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AWS8</accession>
    <name>A0A0D2AWS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231121.1">
        <property type="nucleotide sequence ID" value="XM_016384519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AWS8"/>
    <dbReference type="GeneID" id="27337287"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10204"/>
    <dbReference type="HOGENOM" id="CLU_048479_1_0_1"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38367" checksum="A02E532DCE2622DF" modified="2015-04-29" version="1">MTSPADATGASSLPTHLIIVCCHAIYLGSSGGLPGSGAGSESDVVTRARASRDEKNWLIEPFQQGETDTYIAHVEAGVRALAQDPNALLVFSGGATKRDRTDKTEGDGYFDVAVEHDFFNVDTTATTTGIDTATADATQSSLRLRDRIFVDRYATDSYQNILSSLVQWPIFVEGFKSKTSSSSSSTEKSKSALPGGGGETRPNDIGAVSWPSKLTIVSHDFKRSRFLDLHLPAIQWPSSSVEYVGIDPPFDEVRMLEIQEGDRVRGYGAWRDDLYASGHLLSSKRVKRGWDPDVFRRDVLDRFSHGTTSPPPPPSSSDNNDDGDTRSALEKVVFWNQTTTGRVLTGEDVPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AXF0</accession>
    <name>A0A0D2AXF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231316.1">
        <property type="nucleotide sequence ID" value="XM_016384714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AXF0"/>
    <dbReference type="GeneID" id="27337483"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10400"/>
    <dbReference type="HOGENOM" id="CLU_067143_0_0_1"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="354" mass="40310" checksum="D982504682823918" modified="2015-04-29" version="1">MHESISTSTVDVTGRHHSALDRRQIVDIANWRQRNVYDTFSRGGNPSRSTTNIHRRRGTAIDPSEEGTMSAPALGLTPTMARPHLLGLPGELRVKIWKLVFEDANAAPSRNSHRIYEESCFSCFEEQRPFPMTWNATFEPLLTCKQIYSEAHEILLSGMMIEIRNPIFDLSWLAWPLPPINHKVRRLVVWAHINGHNSRQWVSTCDLLKNAFPAMESLVVKAHMRPQEGAEETLDAAALAGSIVRLKHNNAGLAVTLEYGYRYHKSMWHNPRLGQITSHDIMEDNDRFVRDLIEDREFGEAALQAHRDDADEAALAMAFMRVTIAHEENLFEAMVRSREERQRLGEAKLASTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AY65</accession>
    <name>A0A0D2AY65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_10950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231864.1">
        <property type="nucleotide sequence ID" value="XM_016385262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AY65"/>
    <dbReference type="STRING" id="91928.A0A0D2AY65"/>
    <dbReference type="GeneID" id="27338033"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10950"/>
    <dbReference type="HOGENOM" id="CLU_080002_1_0_1"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="130"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW11648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="205" mass="21312" checksum="40DEF0A103F0CCA0" modified="2015-04-29" version="1">MSFRGDSRGRGGFRGGDRGRGSFGGRGGGRGGFQQQSFGPPAQVFEMGTFLHASEGEMVCESVNPKIPYFNAPIYLENKTSIGKVDEILGPINQVYFTIKPQEGIQATSFKTGDKFYIGGDKLLPLEKFLPKPKPPPGAAKVKKPAGAGRGAARGGFGRGAPRGRGAPRGRGGFTGRGAPRGGPRGGSFGGRGGGRGAPRGRGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AY72</accession>
    <name>A0A0D2AY72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231874.1">
        <property type="nucleotide sequence ID" value="XM_016385272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AY72"/>
    <dbReference type="STRING" id="91928.A0A0D2AY72"/>
    <dbReference type="GeneID" id="27338043"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10960"/>
    <dbReference type="HOGENOM" id="CLU_005049_0_2_1"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="9"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="457" mass="52271" checksum="FAD999A931C2888A" modified="2015-04-29" version="1">MGEASTKNRHVLCFDGTSNRFQANSADTNIVKIYEMLDRETSDQYHYYQPGIGTYDADGPISNTRYWSVFSKVWSKLKAKLDEGFAFSFAEHVMAGYKFLMRYYANGDDIYIFGFSRGAYTARVLSEMIHDIGLLSRGNEEHVSFAWYKWSDYCRAGYKEKDLDYINDYKKTFCRKDVKVHFLGLFDCVNSVANLEVPLFRRISPYLRCPPATHIRHAVSVHERRAKFKPTLFLFAKKHLQEPAEVESLKEHWFAGNHGDVGGGWPVDPGCYALSEIALKWMVDQVLAIQPSEQNNPLSWHKTDPEDPKKGLDGLDSRVNHIHESLQGGRGKELGLVKHDLLVRGGGSSWLGRRFWWLLELLPLSHFELEGDKWVQPWSSNIGGLRDIPEDVAINNYIDPSIDLMVKADVLPVAERPFFGEKPFRGYPYRGLWNLWGLVGRRKISARPATADGEPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYY0</accession>
    <name>A0A0D2AYY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_09186</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232129.1">
        <property type="nucleotide sequence ID" value="XM_016383506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYY0"/>
    <dbReference type="STRING" id="91928.A0A0D2AYY0"/>
    <dbReference type="GeneID" id="27336269"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09186"/>
    <dbReference type="HOGENOM" id="CLU_010247_2_1_1"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="11">
        <location>
            <begin position="32"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="10">
        <location>
            <begin position="358"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="10">
        <location>
            <begin position="547"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="12">
        <location>
            <begin position="591"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="636"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="558"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="392"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="481"/>
            <end position="482"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW11913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="830" mass="90491" checksum="462FB85F8667BDE9" modified="2015-04-29" version="1">METLPRFVIGHHDPKRPLPVTAETIQAAHAANYDMVTSPITTPHFHSRVLTLLSASLSQHPVVDGEDITKTRNASPIVIPPLTPADTPLTPGDTISQIIGVTSSWIDLSSPDPIIADVSRQVLRLELAYAAFCGVTYVVIPGPRLRGQGAVDSGIAEFARAIVDGISQGPYMQLYIWFPLIDNADDQEDEMGDLAPFARQRFSDPDDSKPKRLDVFGSWEAWDMIRSICKYPSRLCVALSLPKLLPPTPIQSRWYSEPVRLVTLDSKIFSKNAKGYPVLSRAHQAFISRFSTLRTPPWFLLCNTGPIVAAANGAPPAPGWFPPLSEAVETPHLKDPTPHLSYMRNLQNKQPVPDAISSFGAGYQDYLQAPLQPLTVNLESVTYEVFEKDPIKYAWYERAIARALHDWIEQGKPTSNPDGRVVVAVVGAGRGPLVTRALKASEEVGVEIDMWALEKNPNAYVLLQRHNATTWNNKVNLVKSDMRTWRGPVRGANTPLSARIYNQEAREDGEVNIPPTAAAAGTGESYTGSPSLDSTYLLATAASGSSSTPYKIDILVSELLGSFADNELSPECLDGVQHLMNPVHGISIPASYTAHITPIAAPKLHADIMHGMTPTNPSAPETPYVVMFNAIDHLSTTTTTTPGSAGPSSSKSPTRSQSQSNPPPTPPTPIIGTTWSFQHPNPSLPPLVGDGALSNAHNARRSTLTFPIPNRGTCHGLAGYFETVLYKGVELSTNPNTMDSKSEGMISWFPIFFPLKTPLTVPDKSELTVTMYRRTDDRKVWYEWLVDVYICIPDGRDRSVSGPGGISRGGRKIRVGGSELHSSEKEACLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AYY6</accession>
    <name>A0A0D2AYY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232134.1">
        <property type="nucleotide sequence ID" value="XM_016383511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AYY6"/>
    <dbReference type="GeneID" id="27336274"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09191"/>
    <dbReference type="HOGENOM" id="CLU_099500_1_0_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050383">
        <property type="entry name" value="GlyoxalaseI/FosfomycinResist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366:SF22">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="14"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="171" mass="18823" checksum="F8E90F712FAA9C6C" modified="2015-04-29" version="1">MTASSAPVPPPPPPITHILETCLMVKDIRTSTDFYRDTFNVKPFLDTPRLSGFSLGQTTLLLFQLGATAADAPMPDDRGTIPGHGPSRDILDLLERQPATAHDRAATGLHQHFCFAVKTPEDVGTWETWLEEKKVKLIGKVDWPRGGKSVYFADPDGNVGEVGSRGIWEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZF8</accession>
    <name>A0A0D2AZF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_09113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232056.1">
        <property type="nucleotide sequence ID" value="XM_016383433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZF8"/>
    <dbReference type="STRING" id="91928.A0A0D2AZF8"/>
    <dbReference type="GeneID" id="27336196"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09113"/>
    <dbReference type="HOGENOM" id="CLU_034451_1_0_1"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002238669" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW11840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="48571" checksum="334699549064E1D5" modified="2015-04-29" version="1">MRLISIFGVHFLAALVHLQSVSGASNSSSSSKAPTLPLSTDSTFNFDFLIPLGLALTGGSDISPVLGVANVVEPGNMTSYYEEFYKLANYTKNQAEDTENAYDPINVRDTWFSASNYFRRADFLIHQNWSNPDIMTLWAEQTSAFNKAIAALPIPGTRIRIPAKKQNFTIEAIWYGASTNKTAKLPTLVVGNGFDAAQEDSYHNFCAPAVLRGWNCITYEGPGQNTVRRYQDIGFMPEWEDVGTPVVDWVYENKADVVDGDRLALLGNSFGSLLALRVAAFEPRIKAVVAIDGIWDFYKSAIAPIPTEVLALYEAGKEQEFDRELLHRRATNQLSTMTAWGLDQGLWSFYTHSPSEFLTKAKEFEVGGFVSKIRVPVFIGNAEFDTFVTGQPATLKQALGTLGTLHDFNGTAGYHCQTGATQEMVRSIFAWLNKTFPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2AZT7</accession>
    <name>A0A0D2AZT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protection of telomeres protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_09223</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232166.1">
        <property type="nucleotide sequence ID" value="XM_016383543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2AZT7"/>
    <dbReference type="STRING" id="91928.A0A0D2AZT7"/>
    <dbReference type="GeneID" id="27336306"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09223"/>
    <dbReference type="HOGENOM" id="CLU_016663_1_0_1"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000303">
        <property type="entry name" value="Protection of telomeres protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="10">
        <location>
            <begin position="12"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="377"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW11950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="645" mass="73606" checksum="CB9A479236748B11" modified="2015-04-29" version="1">MEVEPVPIPPHFISLTEALNKLGTDQTYNVVGVCIDFFAPTQTRTGDYMLTFTLHDPWWTDRNGMKFRFFNKTLAKLPKIQHQGDVVILRNIKTIKTGGAGLGVSNASSIWLVLPFGQVRDIVTPEDVKTKAHWSTSGTGIPFPQNTAPNVAEIKYARYIAASEDPLSWGNLPTTTGTPIQTNVEHDGGQISNIPGKFRLIKDVFPHKFADILGEVRKFHFNENYEETHLQVTDYTTHKALYNRQYRTETAGLDGDEYGYIKDSSEKQWPGPWGQMTMDIILWAPHSGVARREIKPGSLVFLRNVHIKMDKNQSKLEGVCHTEQHNSERVNITVVQPTKEDHQMKALISRKHQYAQQAKAEGKPFYWSPLEIAKKRKAEEVNEPEGAQKNKKTKNRNRKKNKARTETSNDEALTLQTEKKSARALNTNVRCNAYEVPRKSVSDILDPDILLRKSLQGKPYRLPFQNCKYKLHVRVVDFYPDDIADFAVPRNPDYDLLSDDEDEEDFSSMDLTQLSGDRLAWEWRFVLLVEDARQPAGINGQPSRMEVLVAATDGDFLLNMTACNLRDKENTQQLATLKEKLFHLWGDLQERKEEDGTSIMSTLRPKAKPFECLIKEYGVPVRGVKNPVHDESDYDRMFRLFGTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B157</accession>
    <name>A0A0D2B157_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_09687</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232626.1">
        <property type="nucleotide sequence ID" value="XM_016384003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B157"/>
    <dbReference type="STRING" id="91928.A0A0D2B157"/>
    <dbReference type="GeneID" id="27336770"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09687"/>
    <dbReference type="HOGENOM" id="CLU_018204_4_4_1"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW12410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="522" mass="58347" checksum="FA2D1310106DDCDD" modified="2015-04-29" version="1">MAPQKTSQTPTRKLSRAEVAKKNNADEGIWCIIDHKVYDVTDFLDAHPGGSVVLQQVAGQDATSAFYNLHRHEVLQKYDASLCIGTVDGERPEVVDPRPGDLSTVPYAEPLWLTPAYKSPYYGESHRRLQRAVRTFVDEDIYPEAQEKEIDGTYISQGLVDKMARNNLLAMRLGPGKHLLGRELMGGAVAPEDFDYFHDLIVAQELTRGLARGFQDGNMAGMMISLTAVRQWANDAELRDRLTDECLSGKKFMCLAVTEAFAGSDVAGIRTTATKTPDGKHYIINGTKKWITNGMFADYFVTACKTEKGISVIVVPRDDNVETKRIKTAYSTAAATTFIQFDNVKVPVNHLLGKEHNGFIVVMSNFNHERWAITAQVIRWMRTVVEECLKWTHQRIVFGKPLIEQPVIRQKLAKMISRTEACQSWIESITYQMCNMSYAQQSKLLGGPIGLLKSYSTRCAHEIADDAVNIFGGRGITQTGMGRVVEQFHRIYKFDAILGGAEEVLADLGVRQAMKQMPKAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B172</accession>
    <name>A0A0D2B172_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_09697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232636.1">
        <property type="nucleotide sequence ID" value="XM_016384013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B172"/>
    <dbReference type="STRING" id="91928.A0A0D2B172"/>
    <dbReference type="GeneID" id="27336780"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09697"/>
    <dbReference type="HOGENOM" id="CLU_022571_2_1_1"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000191">
        <property type="entry name" value="mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="293"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="337"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="562"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="588" mass="64826" checksum="0D537BB088B4B37F" modified="2015-04-29" version="1">MSGLLGVGYESSDDETPIAQPTRAQPKPINAAPDVFTEVWSLILKHSAGRPNVLQDASEMQIMLANPTSNALTYNATYDNLSRPSQGPINPFKSSTGNALKRKNVLTGHAEETAMSEATFKTQHHTFQSLGYSKDPSLNGAYVGNLEAAAKYGGKDFVEIRHTKEESAMIRAKRQKKGDSSIVDGEGAYLGPWAKYTSDDVAYEQAEAAADQELASDEEWVEEGLDPLPPPPKEATAYAEDSSVAETTEFHGASEFDYQGRTYMHVPQDLDIDLRKEPGSIQNYAPKKLIHVYKYHTKPITSLRFIPRSSHLLLSSSADSKIALWDAHHDRTLLRTFSGHNKAITDTDFHSSGRKFLSASYDRQMKLWDTETGKCISRFTTGKTPHTLRFHPDGNEFIAGMSDKKIVQFDTRSGELTQEYDHHLGPINTLTFVDEGRRFISTSDDKSLRAWEYGIPVPIKFIADPSMYALVRAAPHPSGKSVAFQSADNQIVVYAAGDKFRQNRKKGFRGHNTSGYAIDVAISPDGGIIASGDTGGFVCFWDWKTGKMWHKIQAGGEGTGAVTCVAWHGQETSKVATGGLDGIIRYWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B178</accession>
    <name>A0A0D2B178_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_09951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232889.1">
        <property type="nucleotide sequence ID" value="XM_016384266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B178"/>
    <dbReference type="STRING" id="91928.A0A0D2B178"/>
    <dbReference type="GeneID" id="27337034"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09951"/>
    <dbReference type="HOGENOM" id="CLU_009663_0_0_1"/>
    <dbReference type="OrthoDB" id="3034003at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="658" mass="72283" checksum="BD2D9DE48810FCD0" modified="2015-04-29" version="1">MEEIAPGTYQSQETDENSTINVTIPANFTKMFTSATSGLGDTRSGMFDIQYRRWKFDQNAIINKGKPYVNASSRNISSMISQNSILLVEGVVVDTRKNPGIGFRNHTIPVALERGGIWTEDLTWIEPVSAHNCADTNLSVLIINSNTLEDWGVNTTLWVLDGGAFLDIDVAALESHPWTDNQTRDLFGRAHKAARMHNVIVASSLSISLPTEKKFGKIYMDDTGSADAYMWSISKADAILRVPFVNHYPDGYKKLLALNYSTITQVCKGYYEIEDASNDQRANNITYPLVNCGFLLGAPIQAASQNLSAATFIGVEVNQKNLYVCASANRASIKTVMFRHNSGRLSNLEVRDIVDKEYPTEKSKPLWASEHSYDKAMRFDPLWGIVSDDYEHYGYEEGFYTMRSEKLWPPVTPFVDSSSRAVDGSDALAAVSGFTGRLGNLYGGLIDLEGPDCSGLNDIPMLERFRELSRKQEDAGSILGLIMTDGLAAGFVGTKTAISQKYVQWPASLAVDDTAEGMPAASVAVYSRVIKYDLRHAIPVFIVLTTLLLALLWAGFILISTRSILSRLSNLYNQTNTGRLATNLLGLGKHDPTQDTKDWVAGDGKIRLRSGELEKPGQRCFLTQAGKIGGEDALAGESPKSSESPPVDGREEVTVTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B2V7</accession>
    <name>A0A0D2B2V7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233161.1">
        <property type="nucleotide sequence ID" value="XM_016382458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B2V7"/>
    <dbReference type="STRING" id="91928.A0A0D2B2V7"/>
    <dbReference type="GeneID" id="27335215"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08132"/>
    <dbReference type="HOGENOM" id="CLU_039329_5_1_1"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF30">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="74"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW12945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="336" mass="38221" checksum="31953027AFC457E1" modified="2015-04-29" version="1">MSFPYPTITVEEHWLSQSVREFYAAKSTPDPYDENGLIGRIVPSLVDFREQRFKSMNDHGVTVQVVSHAPNTLALDPATCTKVNDQLAALIHERPSRFAGFATLPMAEPEAAGEELRRCVQDLGFVGTLVDSNCEGRFYDDDFFWPVFKAAEELDVPVYLHPSANEHTKPLLYDGNYPASVAETLSQYGWGWHNETAIHFLRLYAAGVFDRFPRLQLMLGHLGEMVPFMLDRVDRISSLAWPQLGVKLQRSLRQIWDENVWVTTSGMFYLPQMELVLKQCKPERIIYSVDYPFGHNDAGLEFLKMLKSKQVVTDEVLEGIAYKNAERLLRIKATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4M6</accession>
    <name>A0A0D2B4M6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="9" type="ORF">PV08_06664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234099.1">
        <property type="nucleotide sequence ID" value="XM_016380997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4M6"/>
    <dbReference type="STRING" id="91928.A0A0D2B4M6"/>
    <dbReference type="GeneID" id="27333747"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06664"/>
    <dbReference type="HOGENOM" id="CLU_022833_1_0_1"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW13883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="466" mass="51969" checksum="13689D9138BC1674" modified="2015-04-29" version="1">MHPARQVVFRIFYSTSFTVVFLLVTVVICVTPADALYESYKRERLLDIFLLAGDYVVTALIASLIYAARIYTNRLALKDIPKTFMPIEKEDLPGRRVHKLIEDCLKRSAVIAYHARPRSTRLEHESSALVPMTRTGSLGLTSTNETHEPTWGKIEHPGWCSPAATEHPGLEYATVIDELIDLVEAKAVSLAPVDPLGETGPDGIPLPDPRVIDELTRLETMGMRQYLRHLIELGVVPDTSLTVAFLATYERARFSSRPLSDDEFQSLMRMFAELLRNMAPVDLDTLDIESVYSSSVTASEPEGAGLIRPSQIEHDPRRRLSDSTAPSAASTFSTHGSVRRLPHPPRRVSEDSAPSLSSADRKYSDEDTEDDDDTDSRSLRTAPTRVTSARSRRRLTSRSRMVSARSRQTPSLRSANSVGSFRSRSSDRSGLSPRRTRTRSSNGSVIRLTRPNDHSDLPFIIRAPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B4S5</accession>
    <name>A0A0D2B4S5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyruvate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_08901</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233926.1">
        <property type="nucleotide sequence ID" value="XM_016383223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B4S5"/>
    <dbReference type="STRING" id="91928.A0A0D2B4S5"/>
    <dbReference type="GeneID" id="27335984"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08901"/>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="13">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="11">
        <location>
            <begin position="204"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="12">
        <location>
            <begin position="539"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="382"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="613"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW13710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="713" mass="76396" checksum="7226EA197007EE86" modified="2015-04-29" version="1">MQRLPLAQYLFKRLRSQGVHAIHGVPGDFTLKALDHLSPSGVQWIGTCNELNAGYAADGYARVRGLGALFTTYGVGELSAINAVAGSFAESVPVVHIVGTPQRRFQDSRANVHHSLGDGRPRVFAQMHQHVTVAQTNLRDEKTAPEDIDRTIAAALRESKPVYIEVPCDMVSKEVDGARLEKTLMGGDFATFKEVDVGKEDALIADIATRLYNAKRPLILVDRGDGVRSPSLRHEINEFVRVSGLPTLCMPSGSGMVDHGLTNYYGVHSGPVGQIDTMPYVSEADLVLAFGPMFSDTQTLGWRVVPDPEKIITFGKNFVTLPQSALLSSAGSSSSIYPGATTTTSVINLLSLLPRLKKHLDTRRLPTPDVSSLGDFRNVVPRQYPTLTPSTSTVTTTAPPASASSSTSTSPKGDDGKAEDGPIDQTNFYHRLNPYLRPNDTVLLANATPKLCGRDLVLPAGAQIIASGQWFSIGHMLPAALGASLAQHSESIDSGTTSDSIYDSVSGGGGGGAGGDNSTKGGKGTTAAAADATTTTTSVQEGRTILLEGDGSFQVTAQELSTVIRHRVPLTVFLVNNSGYAYERQIHGLHETYNDLAPWKYDELPFVFSGRLPQRQSQEQGQGQEQPCTTTTTSTTGGGGGSSKYGDDDDASASSSYPIRSYVIRTWRDLDALLASEEFCAGQGLHFVDVKMDKYDVPEKFRVVFQRAGEQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B568</accession>
    <name>A0A0D2B568_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_06630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW13850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234066.1">
        <property type="nucleotide sequence ID" value="XM_016380964.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27333713"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06630"/>
    <dbReference type="HOGENOM" id="CLU_024407_1_0_1"/>
    <dbReference type="OrthoDB" id="1288932at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="35"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="424"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW13850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="558" mass="58849" checksum="6ED83BB1AEBFEF40" modified="2015-04-29" version="1">MAAAGGAALPYHEPDIVTILILVSFILLLNLTDYIFDKILYCGLLAQLFLGIGWGTPGANWVGREFEHVAVNLGYLGLLLIVYEGGLMTSFKALKENILLSIGVAITGIALPISASYILLPLVGATPLQAFAAGAALCSTSLGTTFTVMKASGLITTKMGIVLTSAAMLDDVVGLVMVQVISNLGASSASFSAITVVRPVCVSIGFVGAVPLAAYFIIRPFTIWLNRKRTTTPTSYINRVLTWQATALLIHTAILVGLIAATSYAGTSNLFAAYLAGASISWWDTTLEHPTSHAPSGDDSTNHGGRSPSVSCAPSSTSGLEIFEHFFLQPLQRILKPLFFASIGFSVPISRMFTGGVIWRGFVYSIFMFVSKFTCGFWLMRLPGLASSVLKSMRRSNTEKKPPGGNNIGTGAAVAAGSSVVSDAQRPSSDAVPVPKSSVIAEKKQSTRQQSNQGRPRTRPTVTSTSKPISLYPGCIVGCAMVARGEIGFLISALAESNGIFGNEPDGPMFLVVTWAIMICTIIGPLIVGALVARVKKMESRAAGGPGRKDVLGEWGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B823</accession>
    <name>A0A0D2B823_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235219.1">
        <property type="nucleotide sequence ID" value="XM_016382117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B823"/>
    <dbReference type="STRING" id="91928.A0A0D2B823"/>
    <dbReference type="GeneID" id="27334873"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07790"/>
    <dbReference type="HOGENOM" id="CLU_756575_0_0_1"/>
    <dbReference type="OrthoDB" id="4779541at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="366" mass="39445" checksum="D2A0AEA65B62390A" modified="2015-04-29" version="1">MSNSQTEAKKKHRSLGRLLGKRDKTPERPEPLPDSAYGSSEANSADGPVAREETPEVISAEKNSEIANIDQDRNLALRPSTGEVFDEDTGEVVTVVTTTTTTTTTTTTKGGRRQQDVQKEVQREVQRSPNRPMLQEMPAGPSEHEGLVPPATISTSTAPGGRVPVSNGRLSADTPPVPVKSAMRRSGEMRRAMPGAMPVDDAPVSPVDSHFAGRTGMTPPESPSRPNYSYPKRSSLKTMDQPMKHNQSTINDLKAAAKGIHGVGETLRGTFSSTIDKRFPSKNAEKAAVKNARNDEIVQKGRAEMESVPGGWPGYEHTPVDATSYHEPAIPVNGAPRTTTPPGKESKGLGKLFKRKPVAEQGMETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B841</accession>
    <name>A0A0D2B841_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_07825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235254.1">
        <property type="nucleotide sequence ID" value="XM_016382152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B841"/>
    <dbReference type="STRING" id="91928.A0A0D2B841"/>
    <dbReference type="GeneID" id="27334908"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07825"/>
    <dbReference type="HOGENOM" id="CLU_180978_0_0_1"/>
    <dbReference type="OrthoDB" id="5371169at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW15038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="77" mass="7955" checksum="F2F385E04B42E010" modified="2015-04-29" version="1">MSLLEVWQAAASSPFQPAVGKDSQLSLGLLLLLIGLVLTGLFGLNRSPLSIPLFGIPASLAFGFGAVYAICGFGVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B8E3</accession>
    <name>A0A0D2B8E3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_07722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235151.1">
        <property type="nucleotide sequence ID" value="XM_016382049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B8E3"/>
    <dbReference type="STRING" id="91928.A0A0D2B8E3"/>
    <dbReference type="GeneID" id="27334805"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07722"/>
    <dbReference type="HOGENOM" id="CLU_006301_8_1_1"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="619"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="171"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW14935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1160" mass="128553" checksum="4F4BA789BE3BFC43" modified="2015-04-29" version="1">MARPTPSGRNWLRAIIPTGLRRLRWPGKKSIETRIRSMLLEIRPYKFPALEIELLNVLNVGRFGCSMRRVVSPKLLHRREICLFCAFKHTLELRGAASLRPQHRTYRSSAPYLRPAGAAAARVEDFEDDFSQHTPSRELLGWRCRCNHVNAPRRSECTICTSPRPPKAELVYKGTAPSSPSPQPTLSAAAQVATTLPSRSPSQSPSPSSDSRKTDTSQPRYPPGPKGRYPSRTPFDSQRPSRSSAILDQVSSDFGQQGPPIRFGRHGGPKQRSNGDSDTQTSLTGTESGFKIRKLAVNGPPAPDGSVDQDALQSGDRSRSFRPFSGRNDLPGRRHASQERSQSQSTAPDPLSHSRIGAALKPMNRSRYDDRGSAAERTSNQLNPREPRWRSQAHDRSTQDRKATKQPGRHPSRHHDSGSIPQTTSPRSPVSSDVEIEEVDDVGGATPTLETEDDWSDRRKKADKDRGRRSRIFDVEEDNPDYTSRTAKVSSGKRRSAYRGSRPEFDPDMVEDILDEQKRKKKSKRSKMEAVEQKRPEIQIPEFISVEKLAQGLKVRLADFIDKLEEEGFEGARYDHVLDSGTSAMFAEIYGFEPIIDTIDETRDLVPRPPPEDPSVLPPRPPIVTIMGHVDHGKTTILDYFRNSSVVASEHGGITQHIGAFSVVMPGSERNITFLDTPGHAAFLDMRRRGANVTDIVVLVVAADDSVKAQTIEAIKHALEANVQIIVAINKIDKDDADIERVKRDLSQHDIVVEDYGGDFQVVPVSGKTGQGMADLEEAILTLADVYDFRAETDGQAEGWIIESKVGESGRVATVLVRRGTLRPGDFIVAGNTWARVRTLRNDAGALIQEAAPGTPVQIDGWRGEDPMAGSEVLQAADEQQAKDAVAVRQEREESVRTISDLSAINSARTEEAESRAKVLEWEREQGYMKMKANRRPKDNEGWVEKESLGPRQVHFLIKADVAGSTEALVSAVSTIGNKEVVANVVHSGTGELTESDIKLLAATGEVGYAITFNQRVDTGIRRLAEAANVQILDHNIIYKVTDVVAEKLAEQLPPIITHKVLGEAEVGDIFEITVKKAKVKIAGCRVTNGTIRRSEKIRVLRDGEVVYTGTLNSFKNIKKDVTEMRKGSECGMGFENWDSFEVGDQIQSFEEIHEKRSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2B9H7</accession>
    <name>A0A0D2B9H7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA protein C-terminal winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_05345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235516.1">
        <property type="nucleotide sequence ID" value="XM_016379689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2B9H7"/>
    <dbReference type="STRING" id="91928.A0A0D2B9H7"/>
    <dbReference type="GeneID" id="27332428"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05345"/>
    <dbReference type="HOGENOM" id="CLU_021105_1_2_1"/>
    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="2">
        <location>
            <begin position="400"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW15300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="573" mass="65041" checksum="E2CC407EC659F97F" modified="2015-04-29" version="1">MRLNVSRLCATARSNRLYMDARRVPNSINIVRHASQLGPTSNFPGQGQDEDDAEHKGNQKQSGGQHQSPFGQTAAKVFESAATTFASIAILGLAGYSYHIYYKSLVLRKMEEAFTPGDPMLDLATPVVARAVSPDQSEEDSDHWVDRPEQTRIDSIINGESKGRYYLLVGEKGTGKSSMILEAMRKTNGDGVSMFEAHADPEIFRIRLGKALNYDFHEDYIGSLFSIRGPRDTTAILDIERAFNKLEKIALCHRDGSRLKSSRRGPLVLVVNCAHLIRNDEDGNDLIELMQQRAEQWAAANLVTMVFNSDDYWVYERLKRFATRMEVIQIFDLPKGHAIAALDAYRAKYFPEQERDPEILKQVYELVGGRLNFLSRVAKSSDMLNMCHQINQAEKTWFLNQCGILGEDMDDDVMDQQKYASAAMVLARALVEKQEKMDSSYHDDTGHILPQIPLYIARQIMTRADFIQSYDHDNIFTIDSTAMVRADSVPMMNAFKEICAEEGFDEYLEATLDRISAIESINRTKELSFKDLWIEQKGEQRGKYVFVNFDSKGREIGTTEMRVQPDKTPEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BB28</accession>
    <name>A0A0D2BB28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PV08_05870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236036.1">
        <property type="nucleotide sequence ID" value="XM_016380209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BB28"/>
    <dbReference type="STRING" id="91928.A0A0D2BB28"/>
    <dbReference type="GeneID" id="27332953"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05870"/>
    <dbReference type="HOGENOM" id="CLU_067096_3_0_1"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="55"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KIW15820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="202" mass="22078" checksum="BD48996A3839061E" modified="2015-04-29" version="1">MSEITTLSPSGLDANYETMLSKLRDPSLRPSEVRTLVSDLTAILAQRAIEPVGPSEQVAVVVILRSGMAMQDRFLSYFPADSNVVIYHLGLFRDKRTLQAVEYYNKLPPRSPDIVHGYILDPLMATGGTAEAAINILRDWGLTKITMVSVLASEKGLSRVRSIWPEGVKVVVGATDGELDHHGYVKPGVGDIGDRLYGTQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBC9</accession>
    <name>A0A0D2BBC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_06369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236534.1">
        <property type="nucleotide sequence ID" value="XM_016380707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBC9"/>
    <dbReference type="STRING" id="91928.A0A0D2BBC9"/>
    <dbReference type="GeneID" id="27333452"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06369"/>
    <dbReference type="HOGENOM" id="CLU_029464_0_0_1"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW16318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="644" mass="72459" checksum="5297B7B9C5F765F3" modified="2015-04-29" version="1">MPRLQPVQTASRENSIWKWLSEETFRRHVVSLSKKSHQVPINPTLWLPSTDDTHYHETWSGLRHLSIEMEKRLADDVAYILAAKEGVGSVTAVCVEEEQEVEGLLLRISANEGVNQDVRAGLGHVCELLMSCAKNEIARTQCISEVSEVVLNLCHDRIQDRMHFFLTGIPSFRRGNSLTLINSNGVNNAFENLHRDARSPAGKELSRKLSGLGKDFEVFLRNSHSLSRVDQIRELQIIVKKCFSITTSDGKMSFWDALSSAGISPGKWFNNKFIMQIDKLAAYHRIPITMANDVRKRSSRALFANITPFYIEPYGCKSTTISTEGKRVACHVHAEVQMITHYLKSPPRIPPRFIGTSKAACFLCLLFIQSHGLMKVSAIHGRLYDQWTIPDLADYSPEAITTLRNVIKRMNHECRRLIKESHHVRDFPLTSRQNLRELPQYSPVSSVMSRPIAAMSEAPSGRIGVVDGDDYQTPSEPTSPALISVSQPPCLDEQETESVVSQALSQALVGRFHVNSDVAGDSNMDQNVNEREVSEITNNVSEPLFPLPPATIREVQVQPDNPQYIDSMPGVDITVEIESPSVGMVTFEKVAVGGIEHVVNLVNIEDLKLGDELRFERPEDQDQVALRISKRKSEELWVLRLRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBJ0</accession>
    <name>A0A0D2BBJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NCS1 nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW16378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236594.1">
        <property type="nucleotide sequence ID" value="XM_016380767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBJ0"/>
    <dbReference type="GeneID" id="27333512"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06429"/>
    <dbReference type="HOGENOM" id="CLU_021555_2_2_1"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF1">
        <property type="entry name" value="URIDINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW16378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="60649" checksum="877140228E2B01F0" modified="2015-04-29" version="1">MVSFRRPQLVAAGAEEIKGKEIWLDNDDLRPLKLRDRTWNRTTYFVFWFSATATVSNWYGASAAQALGLSLWESLACTLGGNCLIAIIITLNGRAGAVYHVGFPILNRSAFGVYGAWWPTFNRAVMAIVWNGVNAVQGGQCVYVMLHAIFPSIAHVKNTMGTGSALTSAGMIGFAVFWLVTCCFLVIPVPKMRSLVYVKLVVFIISAVAMLGWTVGKAGGLGPVASKGSTVHGSEKSWLIVRFLMLGAANCATFASNASDFQRYAPRPNDPILGNLVGFPLANFLVGVVGNLVGASSQVIFGELIWNPIDFLDKLQTADYTPANRAGCFFIALMFVYCAIFSSIFENSLPAGNDLAALFPKYITIRKGFFICAVVSFAINPWYLLGSASIFVSFLGSYQIFLSSITGVLLCNYYIITRGYMHIPDLFTADKNGAYHYTKGWNIRAYIAYVLGVIPNFYGFLNNMGVDAPMGVTKFYYFAYWVGLAVSGGTYWALCKLYPPAIMYDKGWMEVENYVRPEEEDQVLEGQSFDVEAPGLGAQEKEVTHETVTGLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BBM2</accession>
    <name>A0A0D2BBM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_06036</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236201.1">
        <property type="nucleotide sequence ID" value="XM_016380374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BBM2"/>
    <dbReference type="STRING" id="91928.A0A0D2BBM2"/>
    <dbReference type="GeneID" id="27333119"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06036"/>
    <dbReference type="HOGENOM" id="CLU_016922_12_0_1"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
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                <person name="de Hoog S."/>
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                <person name="Stielow B."/>
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                <person name="Abouelleil A."/>
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            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="5561" mass="606468" checksum="7AD9F981ACCEA894" modified="2015-04-29" version="1">[encoded data, 5561 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BFQ0</accession>
    <name>A0A0D2BFQ0_9EURO</name>
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        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11150</name>
    </gene>
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        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
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        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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    <sequence length="339" mass="36296" checksum="B0D84C9DB26D6A0C" modified="2015-04-29" version="1">MVESGKEIVLISGVNGYIAAQVAKAFLDAGFKVRGTTRKTANTESLTEGPLKAAFEAGDFEVAEVPDITIPGAFDEAAKGVTAILHTAAPVSLSFTDPEPVLHGAIQGTSSILGSALQAGAQLKSLVLMSSIAAVLGSQQPPHTFTEQDWNDFSEGEVARSGKAAGSVHIYFASKTAAERTFWDFKKKHSPSFAMTAINPVLVTGPPLAPFKDANSINETVRNVWQVLAGQDVPPPLNMPANYVDVRDVARLFVWAVQNPERAGGERYIAYGGRGGVHQISQILREHYPQRRGIIKEFPAGESNGNSIDASKAVKATGQEFIKFERSVLDAARAFEIYL</sequence>
</entry>
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        </lineage>
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                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="171"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="235" mass="26443" checksum="B9CFA42DB7F81277" modified="2015-04-29" version="1">MATGRGRPSPPHGTRVSPNAIMQESNRQLDASYHSWQSRRPQLFHQSQAGSVSRMASNTSVRISVIADDQEHVVKLANTLYDGTLQKSLICEAKALATSGVVRRCQPVILLDHTGRTYTSASTISLRWHYDNGLQTFQETFYIVDRLPRADSRHGARDGSRGGEWDAMLRVGVEPCPDGGPPSAYPYMSVPPDRNAQREDERRKLEEELQKQYEEEKKAQVAKIKEKLLKKAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK16</accession>
    <name>A0A0D2BK16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="2" type="ORF">PV08_03209</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK16"/>
    <dbReference type="STRING" id="91928.A0A0D2BK16"/>
    <dbReference type="GeneID" id="27330292"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03209"/>
    <dbReference type="HOGENOM" id="CLU_009600_14_1_1"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
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    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="472" mass="50620" checksum="083E473CAEF66BFF" modified="2015-04-29" version="1">MPSVQLKLTTTTAHGMVFRSWSKDNTATTDLGITCGSCVFYGATVGRDASYVQKLRKAGVIILGKSNLSEWGNIRSTNPGNFRKSNSSNGWSAVGGQTLGVYYPNQDPIGSSSGSGVATALGLAFAAIGIEVGGSIIGPAQRSNIIGIKPTVGLTSRDLVFISKRQGTVGPMARTLEDAASLLEIIGGKCPHDPETSKIPFEHIPKYARFCNKSALKGARIGIPRNAFRDNDEAAADEIDLAGIAKAASIMKDAGAEIIDPADYPEYETFLNESGALRGRVGFADWKADMARYVTNLVDNPQNINNIDDLVEFTQAHPKEEYPSRDVAGLLGVSKAMAQDVPRVEEAWERVRELAVRGGINGAMKKHNLDALIMPSSVSTSVATVALAPVITVPLGFYPENTGIVWNGRRNLVLQDKNLPFGLSFIGLPFTETKLIGYAYAFEQLTKVRDQVDPIVMPKTELRDVAGKDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK34</accession>
    <name>A0A0D2BK34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239499.1">
        <property type="nucleotide sequence ID" value="XM_016377929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK34"/>
    <dbReference type="GeneID" id="27330660"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03577"/>
    <dbReference type="HOGENOM" id="CLU_070881_0_0_1"/>
    <dbReference type="OrthoDB" id="537467at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="284" mass="31106" checksum="BA4368C222B42664" modified="2015-04-29" version="1">MSWMDSWSRPGKRPAVLPPFYLTQEHAAYCQTCGRAMSSRKIQQAQTKIIKYCSDGCRHHKPGPLDRKIERAMVALLNAEPGSGIEETAAKSKFVKGDQRNIITMQEVENLMFRPKPAPPSDSPASRPTAETSDASDIDAQAEHGAPPSEGSVGGLASREGSLEPATSDGSESIDEGSLPGAARPTAEDELKKRQEGHRRAEQREMVRRAARRLVVFGCDQERHNTHGDHPKKPNKRAAKGTTAGVQGSASETVRRKCEALMNGTVVEPSFAKGNWAIRWREEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK70</accession>
    <name>A0A0D2BK70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10976</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231890.1">
        <property type="nucleotide sequence ID" value="XM_016385288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK70"/>
    <dbReference type="STRING" id="91928.A0A0D2BK70"/>
    <dbReference type="GeneID" id="27338059"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10976"/>
    <dbReference type="HOGENOM" id="CLU_014401_1_1_1"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW11674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="61731" checksum="79E727EBE8ECA25D" modified="2015-04-29" version="1">MSLTRVASVDGFEREGPGSGASSRRRMSFNPFSDQLPPAHRRTSVVTEALQFEEVSKQKRLVQVIIAIIYCLFAAGIVFGYAAIKPVLIDEGVFADLCTPEEVEARTSPCYQQEIRLNFMFTVAAVSTNVAALPIGTILDRYGPRACGIIGSVFLLTGALLFSFASKASGDLFTPGYFFLALGGPFVFISSFQLSNTFPRNSGLILALLTGAFDSSSALFLVFRLVYEATGGKLNTHRLFLIYLVVPVFIFVVQVFVMPKDSYKTVSEVVKDAEEEINAPTPPEATQEEIQVYRERRESTIAEVSLLLDKTVNSKRQKREENKNSKSGVWGALHGHSALDQIKTPWFWLITLFTVVQMTRINYFVATIRPQERYLLGSEENAKLVNDFFDVALPLGGVLSIPFIGTLLDNTSTPFALGFLVVVATIIGILGCLPFMWAAIANVCLFVLYRPFYYTTVSDYSAKVFGFQTFGKVYGLIICLAGLFNFLQSPLDAVTHVVFNLNPIPVNVILMCLAVIVGTALVSFTYIKSRSMKREHLEDEAEGATETLMPSANGVGYGTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BK78</accession>
    <name>A0A0D2BK78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231900.1">
        <property type="nucleotide sequence ID" value="XM_016385298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BK78"/>
    <dbReference type="STRING" id="91928.A0A0D2BK78"/>
    <dbReference type="GeneID" id="27338069"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10986"/>
    <dbReference type="HOGENOM" id="CLU_000134_46_5_1"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="532"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW11684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="584" mass="64229" checksum="8C65D51F733656E1" modified="2015-04-29" version="1">MADALKAEGNKAFAAKDFNLAVEKFSQAIELDPSNHVLYSNRSGAYASLKDYQHALEDANKTTELKSDWAKGWGRKGAAQHGLGDLIGAKDAYEEALKLEPTNAQAKSGLESVNRAIEAEARADGADMGGLGGLGNMFNDPQLLQKLASNPKTAPYLADPQFMNKLQRLAKNPQEMGQELGDPRFLQVMGVLLGVDMQMGMPPEGASGAANPTEAEEDVPMPDARPQSNPSPQPKKEPEPEPEPEPEDEDAIAAKKAKEEAENEKKLGTESYKKRKFDEAISHYSRAWELHKDITYLTNLGAAKFEKGDYQGCIEACEKAVEEGRQMLADFKLIAKAYGRIGSAYEKMGDLPKAIENYQKSLTEHRTPDILAKFKAAEKAQILAEKNAYVDPEKAEEARLLGAEKFKNGDWPGAVEAYTELTKRAPDDPRGYSNRAAALIKLLAFPTAIQDCDEAIKRDPKFIKAYLRKAQALFGMKEYNKCLDVCTEAMEHDEGGKNAREIEAQQQKALEAMYAARAGETEEETSARIQRDPEIMQILSDPVMQSILQQAKGDPMALNEHMKNPGVRGKIQKLIAAGVIRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BL97</accession>
    <name>A0A0D2BL97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_00307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239949.1">
        <property type="nucleotide sequence ID" value="XM_016374673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BL97"/>
    <dbReference type="STRING" id="91928.A0A0D2BL97"/>
    <dbReference type="GeneID" id="27327390"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00307"/>
    <dbReference type="HOGENOM" id="CLU_006937_8_1_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW19733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="63332" checksum="E65A9185F935F182" modified="2015-04-29" version="1">MSVDDKTTELDALVVGAGFAGIYQLHTLRNLGYSVKVIDKAEGVGGTWFWNRYPGAMSDSESFVFRFTWDRDDLRTYPWTDRYLQGPEILKYLEHIVDKHNLRKDIQLNTELLSADWDPEQDKWRVTTSTNEVFVARYLITALGLLSTAKLPNIPGLDDFTGEICHTSRWREDFDLSDKRVGVLGNGSTGVQVITALGPRVKSLVSFQRSPQYSVPSGNGPVTPEYRQWLNDHYDEIVESLPKTATAFGFTESTTPYASVEPDKREEVFQRLWDQGNGFRFMFSGFSDISTNKEANEATCNFVRSKIAQIVKDPEKARKLMPQEPYARRPLCDSGYYQQFNRPNVDIVNLRDTPIDHFSATGVETVDGKFHELDVLILATGFDAVEGSYTRIQLHGRSGESLADHWKNGPTSYLGCFVPGFPNLLMISGPQGPFANAPPNVEMQVNLNNELIQRAERLRATGKAATIEAIPEAEADWSEHCNEVAQTTLFPSIPSWIFANVPGAPKPIPRFFLGGLANFIAIVDGVAKAGYDGFAAPLGNGRKEVCNGSSKNGSLDHVTLENGKVEVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BM03</accession>
    <name>A0A0D2BM03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_00188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239831.1">
        <property type="nucleotide sequence ID" value="XM_016374555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BM03"/>
    <dbReference type="STRING" id="91928.A0A0D2BM03"/>
    <dbReference type="GeneID" id="27327271"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00188"/>
    <dbReference type="HOGENOM" id="CLU_033465_3_0_1"/>
    <dbReference type="OrthoDB" id="5384040at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW19615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43193" checksum="0F41367298983C08" modified="2015-04-29" version="1">MLQFREEATPTPTTSTPSTLGIVYFTSTEVITINGGVTNNHVTIAPQTIQIAIPTCLQTITPDKNGYVPPGTCNALWDYYPSFGAALVFAILFGILILVHIWQAVAYKKKFCWVIIMAAFWETIAFTFRALSTRRQQNVAIYLVFQIFILLAPLWVNAFDYMVLGRLIHFFAPGHTLFSIPASTLAAGFVSLDFVSFVIQLVGGSWAGPTASKARQMQGIHVYMGGIGLQQFFILVFVGLAIKFQREVTKTEKHQIPAATSAKEWRPLLYALYATLGLITVRIMFRLVQFSSGSTSSNPLVSSEACFYLLEAVPMLLALLCFNIKHPGTVLVGPESELPGFMATVKTTWLKKKTVRSVGQTLQGGEFHELPTRTHYPSTLTASGRYERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMQ2</accession>
    <name>A0A0D2BMQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_00793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240434.1">
        <property type="nucleotide sequence ID" value="XM_016375158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BMQ2"/>
    <dbReference type="GeneID" id="27327876"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00793"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF27">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="489" mass="52772" checksum="E8FCD306EC191AF7" modified="2015-04-29" version="1">MNYFTFGYDGYIYAGVIAMPTFIEKFGSETPTGHILTASQTSIVSSIPTVGCLVGFVMIAVLADRYGRKITIYVAALIGLVGMALQVAGVNLAVITVGRTIASVSTFVTINMALTLSAELAVPSIRGAIVTLSSVTIGIAGIIASGVNYGTYAIQSSLAWRLPVGLQLIGPCLIILAALFVMESPTFYLIKSDDVRAKQSLRKVRQGYTNAEIETELENMRHQHALRATEQSVSMLDIFRGANLRRTILASSFVIITQLSGLAFATTYAAIFFVQIGNANPFLMVLALCILEWGGACAGQVLIEVLGRRRQALFATSVLFVLDLAVGGLGFAPATNKKATTAIAALCLVFGFFIAATMSPLQWCAVAEFPTARLRNTTTSYALLNANLATLVISYVLPYITNADAANLGPKVYLIFAGCMLLCFIWAYFCYPEVRGRTLAELDEMFEARIPARKFRTYICANALEHTATTIKEGPQAEEAENILEEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BMZ7</accession>
    <name>A0A0D2BMZ7_9EURO</name>
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        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">PV08_00500</name>
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        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="27327583"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00500"/>
    <dbReference type="HOGENOM" id="CLU_015161_0_1_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="167"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KIW19925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="575" mass="64151" checksum="9C3E008E9F63F48A" modified="2015-04-29" version="1">MLGLLFSQSGERTLSATSPYGSLGSERLCRSGTSEETELEQGGDSEEGLFRFIRSPVIDQLVDIYFELCHNRPYSFFHEDNFRRSLANHELPDHLLLAMVATTLRFSSDGQVSTKRQGLDAQAASSSWRIIGDIYLAENNTDIHVVQTLALLSIFDFTAGKARHGSAWVKIGIAIRLAQNMKLMLQPPDQLPFESQEERRRVFWSLYILDRLASCGRGHPATILETSCQLSLPCDELSWRNGKPSTSAATLNQFTAPQSLPSVKNSPFALVVLCASVLGRATHLMLQGVDDKDTVPPWDHRSNLAATQSNLICLEPSVLLQKPLQQLIHEGFSIDGCIDQPALGPLVFSQTLFHLCYCILYHPFLLNKKLKNFQGQIPSSFLLHSFETAYEHAKQLVLQIDAAQAAGCRAFVAFYSYAAVVAGSILALCPHDASESMHAEANSIQQVNVAFLARLGQWWNHTPVALSLLQRLIRESHKFSASTWNTLGHTLICSDDEEFMWTLLDYNAWSSMGPEDVRALDDKNPPSDLWPDMNDFCNTFPQFDWELLPGTHSPLLSEAFRDDEFDGDTIKAQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BN84</accession>
    <name>A0A0D2BN84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">PV08_09862</name>
    </gene>
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            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW12584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016384177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BN84"/>
    <dbReference type="STRING" id="91928.A0A0D2BN84"/>
    <dbReference type="GeneID" id="27336945"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09862"/>
    <dbReference type="HOGENOM" id="CLU_395889_0_0_1"/>
    <dbReference type="OrthoDB" id="4118594at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW12584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="696" mass="78133" checksum="FB6024712238C6A0" modified="2015-04-29" version="1">MPPPRLLHVIPRTGDRMKAEQITHRELATVSSLPVPVKMDEGRALQRSKRHAPKVRSGCVTCKRRRVKCDEHKPACQRCKTNRLHCEGYAPPKTWIFEPRQQPSTTVSSRQLHLASDVIRESGAGIKLYPSKDLHYHGTFAGHPGELMAFEFFAKVTAPVAGRWAAPELWQRLVLRAAWEEAAIKDCIVSLTITSLERGPSQVQISIPTTLRSRDYYYFRAASLLSKHESKPVELCLIASVTFWHFDLFNRRPLRAMIHLHATTSLWQSLRGSAPFSTALGTEIEKLLCSLAGIDSLHESGNASHMLPSPEGYSFRKTQAKTHGFISLNAARASLSRCIWAAVLAYDPSATAHTLRDLADVEHVVFQKEMDGLLDFSDLPLCTLSDCLNLFYSWQQRMWLTPDLIVPFTGRQSLLLHAQLIQSVIQKDVNNSTAGIHDLSESNESLFVRVLDAVADIVRTTQHHKHSNPPTTDNTKPTSLRPLVLFIMRRTNLEATLSRAAQLMEDVEVVEKDTDAVLLLWMGFILENTLAAGPPVPNPLVFQCVRDETDVVRKDANLYHEIPQYVQELGCLSVGTVVNFNYPSFRVRSLYPSAGTMPPQRRRRFLASGDDLEAKNAREEKSIEECSQLDLDDSPDIAASSEKRRKGLMTAWKYYADASCYRCASSSAYSINTPLTPTRLQLLWAPPGPRRPKRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BNN6</accession>
    <name>A0A0D2BNN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_07930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232960.1">
        <property type="nucleotide sequence ID" value="XM_016382257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BNN6"/>
    <dbReference type="GeneID" id="27335013"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07930"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="36"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW12744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="511" mass="55998" checksum="7A41C5F2678AFD51" modified="2015-04-29" version="1">MGATETDTVTHHLASVLPTDGRPWYTKGHLVKLNFTIFSLVLLSSSNGYDGSLMNGLQALPVWNSFMGNPTGSWLGFFNGIYWICNGLAFLAASWACNKYGRKTGVYAGYVFLVAGTALGTAAPDRGSFIASRGLIGAAAGFFANGAPLIINEIAYPTHRPVAASCFQCGFYVGSIVAAWVTFGTRNYSTNWAWRIPSVVQILLPCLALPGVLMAPESPRWHASMDRIDDATKFLAKYHAGGDVDSPLVKFETEEIVNTIKAEQQAHATTSYLDLLKTRGNRWRLLISVSLGVFSQWSGNGVVSYYLTLVLDTVGITSVTNQTLISGCLQIWNLLWAVAAAASVERLGRRPLFITSAAVMLTSYIIITGLSGSFANTGNSAVGTTVIPFLFIFFAGYDIALTPLLISYCLEIWPYRLRNRGFSVMWTTGVLIGIFNTFVNPIGLEHIGWKYYFIFIVFLIAFLFLAIFCYPETRGHTLEQMVFVFDGPEVEVLNADEAAEVVDVEPKREKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPD2</accession>
    <name>A0A0D2BPD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_01376</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241014.1">
        <property type="nucleotide sequence ID" value="XM_016375738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPD2"/>
    <dbReference type="STRING" id="91928.A0A0D2BPD2"/>
    <dbReference type="GeneID" id="27328459"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01376"/>
    <dbReference type="HOGENOM" id="CLU_014602_0_0_1"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112400" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="12">
        <location>
            <begin position="52"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW20798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="645" mass="69196" checksum="784724E4CDB559E8" modified="2015-04-29" version="1">MKSTLLAAALSSFLALSNGYALDVDEAAIEIFQNARRALPNSPRGYTPSKVDCPRDAPSVRSASSLSPNETAWLEKRRNNTITPMRTLLSRLNITDFDAGQYIDNHAQNASALPNIGIAVSGGGWRALMNGAGALKAFDSRTPNNTGDGKLGGLLQSATYLSGLSGGGWLVGSLFMNNYSTVGALQADDSGSVWEFGNSVFEGPESGSIQLFSTAEYYGHLVSDVGGKEDAGFDLSLTDIWGRALSFQLINATDGGPAYTFSSIAISQPFIDADSPFPILVADARAPGETLIGGNATVYEFNPFEMGSWDPTSYGFVPTQYLGTNFTAGRVPDDDRCVVGFDNGGYIMGTSSSLFNQFLLQLNSTDIPDSLRSLFADILGGLDQDNDDIADYTPNPFFHYNPETNPSANSTRLTLVDGGEDLQNIPLHPLIQPNRNVDVIFAVDSSADTNDNWPNATALVATYERSLTDLANNTVFPSIPDQNTIVNLGLNTHPTFFGCDVSNFTEGAHIPPLIVYIPNSPYITYSNQPTFTFSTNNTYRDAIILNGQDVATMGNGTVDETWPTCVGCAILSRSLDRTGTEVPEVCQQCFNHFCWNGTIDSSEPAPYEPTPILAQVDLSSKGISSKLFNRWTAGVAIVMAIAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BPY7</accession>
    <name>A0A0D2BPY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_08376</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233405.1">
        <property type="nucleotide sequence ID" value="XM_016382702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BPY7"/>
    <dbReference type="STRING" id="91928.A0A0D2BPY7"/>
    <dbReference type="GeneID" id="27335459"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08376"/>
    <dbReference type="HOGENOM" id="CLU_003181_2_2_1"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="738"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW13189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="794" mass="85786" checksum="9EC05A5C7A72E9C6" modified="2015-04-29" version="1">MASQHEELADERSHLLSHHSHNRRLGSLVDEEDVASMISSHISKEEQALGESPVGERLPYNDYTTIDWLHDLVKDSFRYRSVHDAKGIRGAIASSFDSSQGWIAAAIIGVLTACVAFLVDVSVATVSDWKTGYCRGRPFASKEVCCTAKSPFTTPLQAETGETCSEWHYWTTSYSGAFGIYVACALLFGVISGTVTLTTKRSLPATAPGVGDRGPVQKPGEAANDQTSPSSAAATGKSIYMAAGSGIPEIKTILSGFVIPHFLDLNVLVVKAVGSVFAVSTGMCLGKEGPFVHISTCVAYLVAVRFPKYRASGRKLRELLAAGCSSGLAVAFGAPIGGVLFAYEEIATHFPRKVLWRAFVCSLSAAMTLKALNPTGTGKLVLFETNYGTSYEPYHYLVFVLLGVAGGVFGGVFCKANFLWSRTFRKYNIIKNYPVFEVFLVVLATALLQYPNPLTREPGDVILKNLLVDCTDSSRSAYVCVQEGDGGSFNKYLGWLGHGILVKLVLMIVTFGIKVPSGIIIPALDGGAFFGRLVGQLPFLAQTISPGIFAMVGAGAFLAGVSRMTISLAVIMFELTGELEFIMPNMIGIMVAKCVADALEREGVYDLAQAVLGHPFLDHDHSMKIVQRESHLVEELIPPPQTMREITVEVPDSGLVPRRLLTEKLSQLRRRGLMDAGLVLVQRSMLQGYLAEGELEFGLETLGLAFPEGCIVRLLPSTTGGPGLPADGDRELDLQQFIDRTPLTICAKAPMEYAVEMFGKLGLRHVCVTEEGTGKLVGVIIKKRLVVWLEGLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ40</accession>
    <name>A0A0D2BQ40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ams2/SPT21 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241264.1">
        <property type="nucleotide sequence ID" value="XM_016375988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ40"/>
    <dbReference type="GeneID" id="27328710"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01627"/>
    <dbReference type="HOGENOM" id="CLU_001743_0_0_1"/>
    <dbReference type="OrthoDB" id="3199820at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057725">
        <property type="entry name" value="Ams2-SPT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25823">
        <property type="entry name" value="Ams2-SPT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ams2/SPT21 N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1143" mass="124785" checksum="A2142B4E3F2BDCD7" modified="2015-04-29" version="1">MATSPNEGVSIRTVRLKVLYTFDIDQKDNHLARWPHSLDVQTAFVDEANQIGVIDLRTCLEAVTTASPEMTANPDSDYTVYAYDYSEPDTPLVGQGMLSKTLADHDQGAGSDAEAMVTGRITKNVMGLFSRNAQETLEVKLRLRPVNTYFQRNRSGSISSQDGVRSWGTGFGGQYARSGSPVDTTGLENMQRMLNGENLPIPGQLSRPGTPTGTQALNAPSRQAAVQSRPSSRAGMRQISHSRRDSFNSGYYSGEENTEEGPARKRAKITKVDWPSKSNLNIERQPDSLRVAASTASSVRLHRPVPINPGVAQAAAAAEDPVRPPTPIPVNKSGKPRGRVGRPRKNAPSNLAQGAQVRESSPALDSASHAELLNIPITSPEETRGRSVSSTPANIPSSPPVMPDHPAITSPALPPLANHDSGFMSGNLDDLFGDDQLLHFEDFIIDKPDETDIGEGAAQAQPADCSEYPTVFEDDYDFGEIATEAPKPEMVPPPLPPPAASRSLARAQSYTPASRASMSSPRLAPAPIPRARQIMEERREQQRLKPIAPALVPKSDPAPRNIQRAQTWAPDSDAIMSDAFGMDESKAKAATKKKVGLEQTKARLENAIAKGEMPPFCDNCGSIETPAWRRAYVKIFHNGWDQIETSLATGECCYKEILETNEDGSVKTFRGYKVEKRAGDEEDKWTAVILCNPCGLWFHKQRCPRPREKWQKKDPKDKGKRKRNNVAKDPKKGNANANPKSDAQTPASDDSSPDTGTEAPDAEENDNEMSNNELPLDETEPQLPSMPRTFRASSAGPGPRGLQARHQNRRPAGRQVQSSPGHRNGSEGLPIEIDLTPKPIRRQLFPSPDKPRVQSDPSHYTTAAKHVTHLPAFVRRSPRLNKTRDVFATQAGSVAITVDGKENAEPAAAVVDDGLADLFEEAPLDVELPPPVTPQRRSERLLLKTPSKTPQRQFGAEMSPNADLLPNFRTPKSKQRHPHPAPSTLHISKGVLEMTPFTRSIHDAILNDAPFITDATGEGKTSDVAEIKKTPPKKAISFDFPDLPSLKNSSPMSAEQLLNFNFSELTTDRLDSDFVDPFTTTGMMPSSPPAGLFDFPNADHCMDDIWFNMVDSNAGQSYPESSAPALVTPGQSLRRSPRTQKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQ87</accession>
    <name>A0A0D2BQ87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxidoreductase molybdopterin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_08482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233510.1">
        <property type="nucleotide sequence ID" value="XM_016382807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQ87"/>
    <dbReference type="STRING" id="91928.A0A0D2BQ87"/>
    <dbReference type="GeneID" id="27335565"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08482"/>
    <dbReference type="HOGENOM" id="CLU_003827_5_5_1"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="63"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="249"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW13294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40114" checksum="A759E4D5B4A0E437" modified="2015-04-29" version="1">MTDEDNQAYSQHVTWIGEQSDGSERDALRAVDPAGFYIRPPPKPHELDGDVTDETQLFQTIHMGAAVVDEDKWKLVVDGLVERAFTVNLTQLRSMPRTTITSFHECYGSPVAPPTTALWRIGNVEWTGVRLAELLRLARPKAQATHVWSQGLDHGSFANVAADKYEKDLTLEKAFSPEVLVAFEMNGEPLTKNRGGPVRLVVPGWFGTNSTKWLCRLSLQDGRASGPFTTTFYNEVDPTDATGQRKRPVWTVEPNSMIIRPKPEEVLSVRRNVEVWGRAWGGQEIVKVDLSLDEGTSWTPATVTPRKQFEWQLWRSELTVDSPGRYRVIARATDKDDVAQPLAGRRNHVHHVIVALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BQC6</accession>
    <name>A0A0D2BQC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241374.1">
        <property type="nucleotide sequence ID" value="XM_016376098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BQC6"/>
    <dbReference type="STRING" id="91928.A0A0D2BQC6"/>
    <dbReference type="GeneID" id="27328821"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01738"/>
    <dbReference type="HOGENOM" id="CLU_021768_3_0_1"/>
    <dbReference type="OrthoDB" id="4105787at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="284" mass="32858" checksum="2C4CD95D08C810D4" modified="2015-04-29" version="1">MVTQKCLGMQDKRLARRGLTPWLALLIYKILSNQYIKRLCNNASHVIFFSKFCIKSTDSTTLAEAQAMQFVSEVTTIPVPRVYCAFEHNGRVYILMERIQGQSLWNGWGQRPPESRTRILDQLRSMLAELRSLQQPKNSMDVSNIVGGPIYDQRLPTKSIWGTFRTIGEFHQALRNGIKPEDISHDGAPEDLRSLISFHEKEWGRPVFTHGDLSSMNILARGDDVVGILDWETAAWMPSYWEYTCAWNVNPQNQFWQKEVDRFLTPLLFEAEMETIRGKYFGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BR06</accession>
    <name>A0A0D2BR06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_01464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241101.1">
        <property type="nucleotide sequence ID" value="XM_016375825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BR06"/>
    <dbReference type="GeneID" id="27328547"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01464"/>
    <dbReference type="HOGENOM" id="CLU_068116_2_0_1"/>
    <dbReference type="OrthoDB" id="2140489at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW20885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="227" mass="25715" checksum="722933CEDC1303B0" modified="2015-04-29" version="1">MAATAIHVPLVDQERDLGAPLRNTTHDIGIGQDRFGHETGDSDHRGARWLGVAPYLEPEHLLDLESVDTPNRLLALALTALAPATNEYATTTYQDAINWGDVMSRLKSLAEEQGYTWARQEFYVVDFRSKLMEDIDSELLFKLDKFSHVEATESGGLLKYWYGTPDADRRNLATCVWRNKNDAIKGGTGPWHKQARAIIPRMYEHIDVRGVRLVIEDNVESWSFAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BRP3</accession>
    <name>A0A0D2BRP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_01639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241276.1">
        <property type="nucleotide sequence ID" value="XM_016376000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BRP3"/>
    <dbReference type="STRING" id="91928.A0A0D2BRP3"/>
    <dbReference type="GeneID" id="27328722"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01639"/>
    <dbReference type="HOGENOM" id="CLU_059435_1_0_1"/>
    <dbReference type="OrthoDB" id="5406216at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031452">
        <property type="entry name" value="Kre1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17056">
        <property type="entry name" value="KRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002239180" evidence="1">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW21060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="165" mass="17311" checksum="893928E9C212E907" modified="2015-04-29" version="1">MSVPLVKTLLFSTLLAGIAHGFVPMPIDALPSNLEADGWSALTTLEPVTVSASHSEPSATVTPSPELQILPVLDPNMIPDLKRQVTGQGQAEAATALSQISPVTTYYANSMVDGTAVQVPVVYTQTFARIPDQWPLPTAGSIGLGTIQGTIGVVKSKRELPSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BS78</accession>
    <name>A0A0D2BS78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_06845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234280.1">
        <property type="nucleotide sequence ID" value="XM_016381178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BS78"/>
    <dbReference type="STRING" id="91928.A0A0D2BS78"/>
    <dbReference type="GeneID" id="27333928"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06845"/>
    <dbReference type="HOGENOM" id="CLU_304032_0_0_1"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="459"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW14064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="978" mass="110949" checksum="85A350711BD93B02" modified="2015-04-29" version="1">MAEQTEPQQQEDGQITPCSSSTIEQQEPAQRPNFLELFEQLRPEIQLMVNKRKFVLPLHMIGDSTRANEWLMKAKCGFGLAHQRLQIATSKKAEFQRLMREYLQSYNCPTARLELWEDINNLNFALAKCIEAIITAQDFLAKFEAQQRSFQPTRPPQQLVEWQSHRGGAGLGTSSVSSNTGGVVLGRTSPQYASSFVSANVFEDMYGPQAQGLMQSCPIQPGDNFATSSILPTSAELHVSPYSRHSAATVTLNRPLRPETGKLCHFCRHDYFGPVAWANFWDLYNPDYPLWDYCFTISYVALETSATQCCWLCTQLYDQIVTRERDSLFDVKLTFWSGPKNGGSAECSRCDVYASYRGADESYANSLAGHLQLRIAVAKADPFQFFAKGTLSKSYFTNFDASTARGWLDECGREHECCKGSEDHTVPSRLLLLDPDEDVVYFREMPQLTSAATENRVEYAALSYCWGRTHSFVTVRSNIDNHFQGMDISMLPKTFRDALSVTRLLGIHLLWIDALCIMQDDEVDMANELSRMRVYYQNAKVTLAILRAEDVDEGFLNLASSHNPKHVKLKNLQTELAPKCYVPYYDKLGRKGTIDFEPNEFIDEGSTFYDERREPLNRRAWTLQERWLSPRVISFPSFDGFVFQCNASERFAGDYCLVDSVEKSDEPAIRRRLQLRLSGLDAEPRQDEDPGDEAFETFELVKAWHYIVEDYSSRRLSEPLDKLKALGGLAELFHSQHEAILGPYAAGQWVKTLPLALLWMVSPSEDVAPAPVQYLAPSWSWASVNSRVWNELYSVDVDQQPIADVKVEILRVHVEPSSKVPFGSVQNVWLRLRGPVVDAKWHINPRKEGRIDVALLDMDSPQKRSHAAVNARIGRIGTAELCDDDEDEDTYMDEPIPLGRASCDTIEARLLVPSEIKVLFVAFVHESVIHCSPAHGYGIIIKEVAPGVFKRVGLFDLDERQHENFFLEHSREMTLCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BSC8</accession>
    <name>A0A0D2BSC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_06910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234345.1">
        <property type="nucleotide sequence ID" value="XM_016381243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BSC8"/>
    <dbReference type="GeneID" id="27333993"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06910"/>
    <dbReference type="HOGENOM" id="CLU_000960_27_5_1"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="43"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW14129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="517" mass="54830" checksum="82AA3247C5EB63B6" modified="2015-04-29" version="1">MPDGSVDVNMVPARDHGELEHTTATATSSSSSSRWVGLHTATIIFQLSAINFLASFANGVIVVGLPAIAQDIVLSQELYLWPTSIWGLTSGAALLLAGAVADVVGSRVVDLTGVVAAGISTLACGLSKTGVQLVVFRGFMGVAMSLHWPCSVSMVTQTVPSGKPRNIAFSCLGLSQPLGFSFGLVLGGVFVDTTGWRTGFFIPGAAILAFAALGFFVLEPDAHTSTTGKLRRLKTKVDWVGAMIAGGGLAMLSYVLATLSADSASIERPNALALLATSVVLMAAFPFWIRFQEKKRRPTLIPNSIWKNRAFTSVCVTVLLSSAVMNSMELFSSLFFQEVQSLSAIQASLRLLPSLIFGTILNLSTGLLVDRIPVLWLVLVASICTAGSPLLMALISPKLEYWRGAFFAQVLEPTAGDILYTVGLVVISDGFPEQTQALAGAVFSTVTQFGIALGLSTMQVISNLVTEDTRYRDKASPPALLKGYRASFWAMFGAMILCAFVAAFGLRRAGKVGLKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BT42</accession>
    <name>A0A0D2BT42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_02150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241786.1">
        <property type="nucleotide sequence ID" value="XM_016376510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BT42"/>
    <dbReference type="STRING" id="91928.A0A0D2BT42"/>
    <dbReference type="GeneID" id="27329233"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02150"/>
    <dbReference type="HOGENOM" id="CLU_017542_1_0_1"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16458">
        <property type="entry name" value="RING-H2_Dmap-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000030">
        <property type="entry name" value="FHA domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042823">
        <property type="entry name" value="Dma1/Dma2_RING-H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="85"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="225"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW21570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="50720" checksum="B1CE6041361A4021" modified="2015-04-29" version="1">MARHRTSTGRRHTSSHPADAPLADGAASRPPNARTVSKPKEGQEGDSKPHLPAIRFFPHQEVRNGRPSLTFAPISRTLPSESSIIRVGRYSEREGIPSANPTGPSDAPVGFKSKVVSRKHCEFSFVDGQWQIRDVASSSGTFLNHIRLSQPNTESRLFPIKDGDIVQLGIDFRGGEEMIFRCVKIRIECNRAWQKKPNNFNKTRHQQLQSLARDQPSADSNSGECSICLGSVLPCQALFVAPCAHVWHYKCIRPLLEGKNSTYPQFQCPNCRAYFDLTADVDIAQSDIDEWMGNTDEQEDAASNANVAAANDANGSAAQITHDGEATDSSATRETPDTSEDSGEHPTVTVSDPIDIPNTSGAAATPRMSGLLARRQASNPESPELTTMNGNIDMPDRPDEDEMDTGLDHQRTRTQTPDPEHVISGEGPLTPRNDAGPFVFDGSAGRSDARELVVPGIPEITGGSPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2BZ70</accession>
    <name>A0A0D2BZ70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PV08_03787</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236815.1">
        <property type="nucleotide sequence ID" value="XM_016378138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2BZ70"/>
    <dbReference type="STRING" id="91928.A0A0D2BZ70"/>
    <dbReference type="GeneID" id="27330870"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03787"/>
    <dbReference type="HOGENOM" id="CLU_011500_3_1_1"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="13">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="14">
        <location>
            <begin position="124"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="254"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KIW16599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="704" mass="78446" checksum="529A05C93F728DB2" modified="2015-04-29" version="1">MAAVAQDFSTSPAPAVASVPHPLSPLTAAEISTTADLLRSVWPSTVDLRFKVITLDEPAKKSMIPYLEAEHSGAPLPQIPRKSFVSYYIRNTDRFHEAVVNLTAGKVESNVRLGPNMHGNGDYDEILQVEKNALEDEGVKEALKKLQLPEGTVVCADPWIYGSDGINDDDRLYQVFLYMRDPANPDELDSNHYAFPLAISPVVECNTYKVIRIDYLPTGADNTIREPRPYEAVAPNEYISEAQPKLRQDIKPLRVIQPEGASFTLTPTGETGHVLEWQKWSFRVGFNQREGMVLYDVRYDSRPLFYRLSLSDMNIPYADPRHPYHKKSAYDLGDAGAGAMANNLKLGCDCLGHIQYISSVITDDKGVPTPVENCVCVHEQDAGIGWKHTNYRTGRAAVVRNRELVLQSIITVSNYEYILAFMFNQAGEVIYEVRATGILSTQPIDHELDKTGVPFGTVVHPGVLAVHHQHIFSLRIDPMLEGHANRLAYDEAHALPIDKDWNPHGVAYDVTETVVETAGGLDLDPDTNRVFKIQNAAVRNPVNGKPVAYKIHAPPFQKMLAHPSSFHFKRAEFADHNIYVTTHRDRELYSGGWYTNQSRGGTGVRSFAARNDSVKDTDIVVWVQFGINHVPRIEDFPVMPCEILKVSLKPVNFFDKNPALDVPPSEQNFNQSTLVSEAHHQPALEMKVGEGSCCATPEASKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C218</accession>
    <name>A0A0D2C218_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_04894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237915.1">
        <property type="nucleotide sequence ID" value="XM_016379238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C218"/>
    <dbReference type="STRING" id="91928.A0A0D2C218"/>
    <dbReference type="GeneID" id="27331977"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04894"/>
    <dbReference type="HOGENOM" id="CLU_010119_10_0_1"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="76"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="272" mass="30198" checksum="1CE1A23714ABDEF5" modified="2015-04-29" version="1">MSTDVTNIEESFNVPKIIPEYENEVRHPFFDPYRAEIAGFSRKAMAIASKIFTLFSIILELPPSYFADRHEYDSPSEDHLRYMTYHPRSAADDAKVQNTWSRAHTDFGSLTLLWNQNVAGLQIKTAATGQWKYVPPVPGAGAGGDDDNAGTAIICNVGDTLSFWSAGYLKSTTHRVVRPPEDQTGADRLGLFYFVRPGDDVDIKPVASPLLKRLGLVSTSDKPGGGEGDRPKITGRQYVRERVKNYHNHGDYADMKGKKFQIGGLEIEDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C2H8</accession>
    <name>A0A0D2C2H8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238060.1">
        <property type="nucleotide sequence ID" value="XM_016379383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C2H8"/>
    <dbReference type="STRING" id="91928.A0A0D2C2H8"/>
    <dbReference type="GeneID" id="27332122"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05039"/>
    <dbReference type="HOGENOM" id="CLU_011082_1_0_1"/>
    <dbReference type="OrthoDB" id="2624308at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="92295" checksum="F3FB0638C76D424F" modified="2015-04-29" version="1">MEETEEWLEQSAQFLGYPTTWKTKPGQVYLDNYIYRLNPAKQSSPARKKCDAELTASGKELVKLKVQATAALQGSDNSTWQRHHIADVNTTTLQISKAPNRSRVTAAEKWDPRVAWLVFALNWILALSAVLQWMVFLLLRAMCRYCIPDRQAEQPLTYLPFHCEAPRYARVAASLRDNRNPERQMNTVTDGFSRIGEQTYRRFRPRTLMKRNNDKEPELVKKPPVTARYVFIAFSFRHFPLHTAAGTVSDEAIELARVANKMAGSLGYEYYWCSMSCGAYDGTLTDALEIQNRSIYEISDVIRGADHVIIVLPPTDRQAPTPPLKDLTVDGQPALTEERDDTKQRLKEWAARLWTFPEVILGRSEKIMVCWRKGGSINWYELEKRLFPIQVWNDNETSRQLVEHYGSTNLSRIEFVKIVLECLLHRQVETKVELYYPGDISYVLMGFLRLRPTVNCHDSSLQAFARLSLPADNDRLMERFLCLQPPSRHSNWAEMEDEFHASLWNIEPSIQVSGVGENDTLLIEKAWGAKIQLNKFSDICAADVGFGRHFQGVLAGFAIVPSWSEWLGRSYRRAKLRNTYPRLFGFEGFMSIGEIEEKLFGGPVGLLSWSKNGSPLSRHGPGPEVLESKLHWSDSEDTELGEFGRDSVDVTTRDGTRRVKTYPVIGKEPWGPCDEKCRQAREKRGRCSHPTQEELRQMGRSAMGQDKIFSLIDTVTMTVTVFRAAWPPQALIACGTEGGMERVLVCSYDWTSGVFFKEAVLKFPGKILDSMHRLPTIRLGFQRADRVGTPADRILDRTGLQGISVDQQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3F2</accession>
    <name>A0A0D2C3F2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_02437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238365.1">
        <property type="nucleotide sequence ID" value="XM_016376795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3F2"/>
    <dbReference type="GeneID" id="27329520"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02437"/>
    <dbReference type="HOGENOM" id="CLU_071379_2_0_1"/>
    <dbReference type="OrthoDB" id="5580261at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="228" mass="26072" checksum="7B377B8F54A78E79" modified="2015-04-29" version="1">MFRSIPRSARSTRNSAPGRRRISQSKTNAHEHPPPPPRPRPRPPLPPTDEQAALRGRFERFIDRTPRFLRRGLDGLRRAPVSHATAFFILHEITAIIPLFGLASAFHYWQWLPPYFAEGAWVVDGVERFGRYFRKKGWISANDEEEVEEQTKDGQATRFEKKDGVTKWFGRGESATRWVVELASAYAIVKVLLPVRIFLSVWGAPWFARLAVIPVGNAARSLFRGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C3J4</accession>
    <name>A0A0D2C3J4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_02497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238425.1">
        <property type="nucleotide sequence ID" value="XM_016376855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C3J4"/>
    <dbReference type="STRING" id="91928.A0A0D2C3J4"/>
    <dbReference type="GeneID" id="27329580"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02497"/>
    <dbReference type="HOGENOM" id="CLU_070319_1_0_1"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="31"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KIW18209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="240" mass="26113" checksum="62B316BD9C73534D" modified="2015-04-29" version="1">MPSSLPHRAVIAITSATAPLHHGEPTGFFISEALHPYNVFKAAGFEVDLVSEKGTYVADWLSLQESFLDGEDKKQWEDLDGEFRKKVDNMPDVKSVDGKNYGIFFASAGHAALIDYPHATGLQKIATDVWNQGGVLSAVCHGEAIFPGIIDSTTGKSVIAGKTITGFTTQAEYEMNVMEPIRSWGEPLIDEWAEKLGAKYVRAEGVWDDFHVVDGRIVTGQNPQSAKSTAKAALEIFGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C555</accession>
    <name>A0A0D2C555_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PV08_03018</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238945.1">
        <property type="nucleotide sequence ID" value="XM_016377375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C555"/>
    <dbReference type="STRING" id="91928.A0A0D2C555"/>
    <dbReference type="GeneID" id="27330101"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03018"/>
    <dbReference type="HOGENOM" id="CLU_010413_2_0_1"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09123">
        <property type="entry name" value="PLDc_Tdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09194">
        <property type="entry name" value="PLDc_yTdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000038">
        <property type="entry name" value="Probable tyrosyl-DNA phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="534"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="618"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KIW18729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="72154" checksum="6D5F4FC96BE3CDA1" modified="2015-04-29" version="1">MDYRPSKRVKRDSGTTSSEIVAGETVDAAGVRARRARFLSSISRPISPPGTSRSGTGTPQPETSTASISDQGSAQPPASQKREHRTRTLREGEPTATRKPNGQDRHVRYIPSPFRLTSIRDLPASGNNDTVSLHGILGNPLIKEAWIFNYCFDVDWLMTFFDPDIRPQVKVKVVHGSWKRDSENRIAIDEACKRWPNVEALTAYLPDQFGTHHSKMFVLFTHDDLAQVIIHTANMLHKDWTNMTQAVWQTPPLPKLAKKPSDTVGNIGSGSRFKYDLVQYLTAYGNKTRSLREQLVTYDFSSVRGALISSVPSRMKDFSIESTVKELWSQKLYGYPSLFRALKTITTHDYDEEKVALKNDAPSHPHVVCQVSSIATLPVTWLNQFFPPLSGYKSGQKMWDHISIIFPTPSNVAASLDGYASGGSIHTKAQSAAHLKQIATLKRSLCQWTQGPQLGARAGRDQAAPHIKTYVRFKEKPSVHNATPGVEWALLTSANLSTQAWGTLREKEKVKEIVVQSYEIGVLVWPELFDGGFDTGENERHGTRHSENDDDDGQAQTQTHARDDKSTARMVPVFGSDDPKEFIVKAGPAPSDGNDDGDGDGRTTLVGLRLPYDLPLTSYEHGDMPWSPQGTYDVPDRQGRRWPRDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C5M7</accession>
    <name>A0A0D2C5M7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_03163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239090.1">
        <property type="nucleotide sequence ID" value="XM_016377520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C5M7"/>
    <dbReference type="STRING" id="91928.A0A0D2C5M7"/>
    <dbReference type="GeneID" id="27330246"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03163"/>
    <dbReference type="HOGENOM" id="CLU_031989_0_1_1"/>
    <dbReference type="OrthoDB" id="5393057at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAT" evidence="2">
        <location>
            <begin position="228"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW18874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="560" mass="61432" checksum="105C40292C23AA04" modified="2015-04-29" version="1">MKKLLGNIKKKNDSPERNGSSPVVLPQGDSPEAVVVREMTAFCESGAPNSSSAGDEYLHLPAIVDAAESSPTAAKEAAATLRRFLSKENYPRGYAQYNAVMLARILTDNPGPVFTQNFDAKFVHTVKELLRDGRDKSVQQILRETLDYFEFEKAPGNDTLGPLMEMWRKEKGKRNTIRPSVGWASMEAVGPDHLADGQQNYRVPPPPLAGQYQYQHHGNGHRREDFLPPPEELAARIEEAKTTARLLVQTVQSTPQSELLANELVTEFADRAKNAQRSIQKIMNCQNPAPDPDTMLTLIETNDQLNIAMSKHQRAILQARRSSGLATPSPHAETPQSSAAMPQHNLGQNVYSSGSLHDNRPYPTSPPRRQDTVPSPVSPPRQETPEHFEPPPGPPSGFRGPVRAPPPSTEYDYADAYSAPEQAPPIPQRVRPQSQSYAYGVPENPFTDDAYGQTGVQQQPSRNLIDLGEDTPSTQPQGNQFSNESSVAQSRPGPYGTDYQPTQSYMARQDSSAAHLTMHGGTPPSSAGNQTQTNGAYGSSPVSPVDERETVGRRMNDMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C616</accession>
    <name>A0A0D2C616_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_03263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239190.1">
        <property type="nucleotide sequence ID" value="XM_016377620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C616"/>
    <dbReference type="STRING" id="91928.A0A0D2C616"/>
    <dbReference type="GeneID" id="27330346"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03263"/>
    <dbReference type="HOGENOM" id="CLU_129470_4_0_1"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW18974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="98" mass="10507" checksum="46808D86D46B904D" modified="2015-04-29" version="1">MAPAASSGGKKQKKKWSKGKVKDKANHAVVLDKATSDKLNKDVQSYRLITVAVLVDRLKINGSLARKALADLEERGVIRKVVAHHTGGIYTRAAAGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C6D4</accession>
    <name>A0A0D2C6D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_03416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239340.1">
        <property type="nucleotide sequence ID" value="XM_016377770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C6D4"/>
    <dbReference type="GeneID" id="27330499"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03416"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="128"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW19124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="569" mass="62520" checksum="C5AD49C2E017F011" modified="2015-04-29" version="1">MLDTIRDAPLGQLIRLVTNNRVLLYPDEKPGFTLPKVAPESPGEPEPDNSGRPNTDEEAAGRLSLERQVSRVFTPERLELDQQLELEKTKSIPISLHKTADGTVLVDWYTTDDPENPQNWSRGKKRFVLIQICLYSFAMYAGSSIYVVGEAGVMEEFGVSQAAAAMGLAIYVIGYGIGPLLFAPLSEIPAIGRNGVYTPTFVLFVILSIPTAVVKNYAGLLVLRFLQGLLSSPSLANGGASVADMYNLLMLPLYLSAWTAACFWGPALGPVIAGFAVSAKGWRWSLWELVWMSAPILVLYLIACPETSSSTILRRRAQRLRKTLRRNDLRSQSEIQQANMSVSSIFVDAVIKPVEIMIKDPAVLFTNVYTALTYGIYYSFFEVFPLVYIDIYGFNLGELGLTFLTIGIACVIGVSVFTAYLMLYLVPDIRKRGLRAPEHRLVPALFAVCTLPMGYFMFGWTARASVHWIVSLIGVVILVFSNYIIFQCIFVYLPLSYAQYAASLFAGNDLIRAAFAAGCVIFSRPMFITLGVGGGVSLLAGLAVVGVFGMFALYFFGAKLRARSTFAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C7M2</accession>
    <name>A0A0D2C7M2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_00106</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239750.1">
        <property type="nucleotide sequence ID" value="XM_016374474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C7M2"/>
    <dbReference type="GeneID" id="27327189"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00106"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF62">
        <property type="entry name" value="HEXOSE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW19534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="537" mass="58437" checksum="C101FC174B968481" modified="2015-04-29" version="1">MGLSDMKFTPYTSAMGLSGLRLQFAIATIATCAFWLFGYDMSIMGGLITEEPFLSVFPETKDATIQGIVIATLELGALFGAILCMFYGDRWGRRGTVFVGMLFMLVGGILQASAWHIAQMVVGRFLSGVGLGLQVATIPAWQSECAKPKSRGRWVMIEGGLQTSGVACGQWVGLGFFYTSGQVQWRAPVALQLVPAAIVFFFIMFLPESPRWLVSHGRFSEGKEVLSKLRNLDESHPDLVAEFAGIMASHEAQKAEAPFAYKELLQNGKTQTFRRMLLGVFVNAAQQLSGINMVSTYANQILSTSFDLSPGTSHLIAACGGTEYALCSLLAVFLIEGLGRRKAFMWTATGMAACFVVIPILLSTSSRSNQLAGAGLLFLFNTFFGLAWVGGPFLYAAEIAPLRARAPSAALGSVSNWTCCFLVVMTIPASFANLGWRTYIYYAVFNAVFVPVIYFFLVETKGRSLEELDVIFATPGDPVKNEKRLPHDISVRDAKVALGLEDHALALGDLDDDAAVARSDKEIEEVAQVHTVEKRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C840</accession>
    <name>A0A0D2C840_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_00318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239960.1">
        <property type="nucleotide sequence ID" value="XM_016374684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C840"/>
    <dbReference type="STRING" id="91928.A0A0D2C840"/>
    <dbReference type="GeneID" id="27327401"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00318"/>
    <dbReference type="HOGENOM" id="CLU_042069_0_0_1"/>
    <dbReference type="OrthoDB" id="5377009at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="433" mass="47849" checksum="F2BE7D141E2B66E9" modified="2015-04-29" version="1">MSRDKFQDRLAQPPPRQSCLDVEDDTPISVPPPIPTSGLQRLRTAVELPPLSAWTPSSSPTRASTFLPFLRPQSTRTVSPERVSVAETAESSVSAELSVTKRRPTGAVERLASWFEGSSEPVNITLVPSPRKEKTDPLVETETMDAIFSAGHSSKDNFTRRSQERPTNASTSRFSFFRKSTVSLPHETLGEDELVNMNVEQALYPHGRPDEYSPAAFKNLEQNAEGTIRRFQHAYTEQQLSLKQITSAKNVQSDELDAAQTRNEHLKMQLQEMAERATEQERMIARLRAELAAQRSSLDTFTSRQQSVRMVSDDGPSEAESTPRSRYRRQRSSDVSTSGESELGSDVSSVVSVFSEPLSPASSKTTSAASPVSKVSMMSAREDCPNCHGMHTSEAWDVINVMRAESTALKQRVAQLESAQDDALDFLSGLKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8D3</accession>
    <name>A0A0D2C8D3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoglycerate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PV08_00399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240040.1">
        <property type="nucleotide sequence ID" value="XM_016374764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2C8D3"/>
    <dbReference type="STRING" id="91928.A0A0D2C8D3"/>
    <dbReference type="GeneID" id="27327482"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00399"/>
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        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
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            <end position="325"/>
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    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
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            <begin position="118"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF00389"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35926" checksum="3EE0BC56C8BF8EB0" modified="2015-04-29" version="1">MAPSAVSPPSSIIGITKPTLYLLDTFHPAAIERARELFTVILPSDPEFTDWQQHAKYLLIRASSLTAAQIESAPHLLAIGKQGVGTDRIDAAACAARGIKIFNTPGVNSGAVAELVLSLTMSLARQIRPISVRIARGEVVRKEECDGLILHKCTLGLVGMGNIGRKVAEIFRGAFQSEIVAFDPYMGAGAWPDLPHKRVTKLEDLLKVSDVVSLHVPLTSETRGLLSYEQLAMMKRSALLINAARGGIVDEADLERALADGLIWGAGLDCHEQEPPTPERYEKLWQHTNVISLPHIGAATSQTQRETATAAVENLYAYVKQREEATVNEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2C8R4</accession>
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                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF32">
        <property type="entry name" value="PROTEIN KINASE COMPLEX COMPONENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07660)-RELATED"/>
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        </location>
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            <begin position="88"/>
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        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW19934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="38695" checksum="786107A7876BCA6F" modified="2015-04-29" version="1">MSQSEGHGNQKEPESCTYRAEPPAPPQPENDKGIFPSIKSPLLEGLDEITPDNVDIFKLEAVQALKMLCRSVDCLVQSTGDVPPTPPARSRGPSPARAPSNLHESSAPIAMTPRKDNFGGLRPPGQHTPEHIDGVLFVKTPIGSPEAHAHEPTSAADIVGAHAQPTYVQHGALARKFFSKRPPPISTEDYLMRMHKYCPMSTAVYLAASLYITRLAVYDKILPVTPRNVHRLLLACLRVAMKALEDLCWPHARFSKVGGVSEGELGRLEITFCYLMDFSLKVDAAMLQHEAEALCQQNRFESAIFTPAPTTLDLKLSEDPNKRPRSAEKRKASSTLPSRPLVQVGAGIEVMGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CBM0</accession>
    <name>A0A0D2CBM0_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">DUF3824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016375854.1"/>
    </dbReference>
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    <dbReference type="STRING" id="91928.A0A0D2CBM0"/>
    <dbReference type="GeneID" id="27328576"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01493"/>
    <dbReference type="HOGENOM" id="CLU_010781_1_0_1"/>
    <dbReference type="OrthoDB" id="3561737at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024436">
        <property type="entry name" value="DUF3824"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35487">
        <property type="entry name" value="DUF3824 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35487:SF1">
        <property type="entry name" value="DUF3824 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12868">
        <property type="entry name" value="DUF3824"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3824" evidence="2">
        <location>
            <begin position="503"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3824" evidence="2">
        <location>
            <begin position="655"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
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        <location>
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            <end position="738"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="824"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    </feature>
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        <location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12868"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KIW20914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1060" mass="118604" checksum="50B4DA55B3E20C1E" modified="2015-04-29" version="1">MGSVYRDRYDDSRTSVSSTRRDGGYTTVKRYVVKEDDSRSSVGRDRRSFVPERAGERVEETRIVRRERDVEEPVRDVHRDDARLSERELVIRRERDDEPRRDRDYYERDYYNVRREEPAEREIVIRRTTEREEPRRDDLTVARFDDRTRDVRVSETTRYRDDFEVLPPTRGGFDDRDLQKYTRTAEYFSPPPPPPQTIIIRQEPIIIRERVRDDDYQIVRKSDVEEERSVVRREPPRGEEDFFYEKKVRERIDEPDDYYERRTRRGRSVSPHDSVSQRGRDYSSDDSIVYVRKETREDSSSPHRKRNLAAGVVAGIGAAEILRHHKKKEGQDTSHGIGRIGRDVGAGALGALAAEGIERYRSKSRHRSRSRSSSRHRSRSRRRRSRSRSESPSKLKTLGAVGLGAAALAAAATFAGKRLAKGNDDDGGRRSRSRRRSSSRRRSRSRSASIESLENDPSAPSTDARNPKHRNKRIAEAGAAGAIVAGLIERARSKSRARDGRERSKSRVRQALPVVAAGLGSAALAGLYEKNKAKKEAEQIVKDERRARSRSRSRARSDAYYDGPREGAISDPGLIEYGAGPMYGNNYGPDYYGRPPPPEGYYGASNAVVPAATGAAAGAYGAQRARSRSRSLSRERGGRRSSRSSSSSGGGHYSRRRSSRDAAKMAAAAGAGAVAASEYDRRKQEKRERKARRRREENYGHDPYEDNYNPAQQYPPTPPPPVNDPYASQQGFYPQTSQFPPPPGAVPQQQYPPQTSTPGPTAGNPYGQAYPPPPPGPPPNTTVPTYETYATGANPYAPRGPENVSAVPNSTSGHPFVPATSNDQSHVHGVNGTVRAAPSPPIEVHSLSNTIPASYEPPRGNLTPTNAYTSSMDRSPSPPRSRSQPPSTSRKSVQFAEAPQVATVPNEAAKETEEVAPDRRRHRHKHSHSGGYEAEDDTDSTPDDLRRGTREPSSRSQDPESSERRHHRRRSHEPTSSRNDSSKSSKDRELERVISPADSDATIELPPRFDERGRKKPETGDDPLADKIDEILTGKGAAGKVFGNFLDGLFGPDGRRKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2CCT4</accession>
    <name>A0A0D2CCT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoprotease family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241525.1">
        <property type="nucleotide sequence ID" value="XM_016376249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2CCT4"/>
    <dbReference type="STRING" id="91928.A0A0D2CCT4"/>
    <dbReference type="GeneID" id="27328972"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01889"/>
    <dbReference type="HOGENOM" id="CLU_004045_1_0_1"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="840"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1273" mass="138968" checksum="0098475D66AA83DD" modified="2015-04-29" version="1">METSFEPSGMSSGVVDAQETYRSQRDLMRGLRPVPSSIETYSASTQSKGTNWTTDDKSSPSSTFISSISDYESGSSCGKDQFYLERYSQGVQNAQVSSRATEKNTIRTKKPVVSTSDAENRRLPGLNIVTNFSTPLLRSQNESIVVDQVQSQRPRIGKRCATSVVSAKAEHVDQTTINLALEHSMASNTTMTHTSGHDRNRAREAYSKWQDLQTARRKLSDEASAQRTASVADYDSLVTIDLGTAQRKDQSSEKRSVVIGLSLPSNEANAHRLRDAANDTHATTTPETPVIVITPAEEGDSWKPQSMRRLRPSSSIYSTRSGPHDTRSGETLPPVPAMPEVHKKGHIPVGEAITLQTAGYAKSGEEEDIAFDGERDFQNPESVQRASSESQEHILPKEGDMARHRSQGWWNLMLSPMLSRKGTISEKTRTNNFERPPMPPISTLDEVDKHASVSSVFAESPETPRRLGLASPRASISARWTFWAKSKGMERHLDRTDDVTSKVPKDQTFAGDAQREPPIESFGGAGVGLAAEYYHACAVEQLSGVRYFECNNHSCVERLPQLQSLFDHEAGENATALEVGAEKSLDDIKPNVSVEHRIKSLATVNSEQEELSPNVRDASTAPVTKAKAIEAPAAGTSTVVEAVPRDDSNNVGNRQEVTPSPLEQARTLNTSTARQNVQSPDDKSSIPREFIQAAVQSPGPISPVVQEAMRSYGDVPMSEMSHPRHAVQSPEQTKKQVENPTSEQTQVAASTLHHHTTYSERLITMPAPLSYETRENHQIYAVPATTNRHMSESTPPKPASLKRRNSGGPEKSGMVAKIKSLFKKKGAKTDEDLQPTKRKWTLIVGAFLLLIVIACILLATLLTRHGDETPTQSQWLNLTGYPPIPTGISTIAMPDPVQEQSQCVAPTTMWSCALPKENQAEIAPNSPDQPNFRFEITFKNGTVPGNMTLPVNELRKRSANLSPRASDPFTKDLLEPNPTPPSRADEIFLGNTTDNITEPFQGEDTPFFMTFIPVFPLDPFNSTQGNLATSKLLASRDSNNSDIIPAPDVLDDGSAAPANLLPTSPYPTSQPIKLYNRGQQDEHFGFYMYYDKAIFLRSTAPLNTSQFSNNNGIDAADEDGGCTRGQSRLRCTLSQTRFLVRIWTNHAFDGTLLSPIVSNTSMGAGNNSATDFNRPGSFPYPTTISLDRHGGNINKKAVYCYGVNDLQVIQNDVKGIVPELRGFGGHLINPAPPLVEEGSGSGNATAADDGFDPEAGGIDGGTGGCGCVWQNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y5F3</accession>
    <name>A0A0D1Y5F3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_11122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230377.1">
        <property type="nucleotide sequence ID" value="XM_016385433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y5F3"/>
    <dbReference type="STRING" id="91928.A0A0D1Y5F3"/>
    <dbReference type="GeneID" id="27338205"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11122"/>
    <dbReference type="HOGENOM" id="CLU_023312_0_0_1"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="78"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW10161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="424" mass="46629" checksum="0A4AAAB4E45D5A5F" modified="2015-04-29" version="1">MDAPTLPSKCPGYNIYIDGFQALRRPQVLQACNITHVVSVIDWKFKPGWDPLRGVQHLHIPLDDVYDSNILEYFPRSNAFIHEGLNYRSTKSSEGLRESGVLVHCAMGVSRSATVVLAYLMWISRQPRTIQQPEKESSSGNEGNDDSTPEMISLPPTPLTVDSALALLREGRPHVEPNSGFIKQLRMYEAMNCPTTQEQLESQKIYRRWINSRNVMDALSSNRAPEMANITFRDEEDDSDDESNSKIHDQMGSLSLSGSDAEITNPDISSSSSPDDAASPASDMELKCRKCRRLVAKSNFIIPHKPPPHRDPSAGASSEACAHIFLHPLSWMRNTLSHGDLDGRLSCPNPRCGANIGKFAWQGLRCSCGGWVTPGFGIARSKVDEARSSRRGAGPNVQGSPVPGNANAVRLPPGMRRASENGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y5G6</accession>
    <name>A0A0D1Y5G6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PV08_11137</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230392.1">
        <property type="nucleotide sequence ID" value="XM_016385448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y5G6"/>
    <dbReference type="STRING" id="91928.A0A0D1Y5G6"/>
    <dbReference type="GeneID" id="27338220"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11137"/>
    <dbReference type="HOGENOM" id="CLU_001103_9_3_1"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="36"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="270"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KIW10176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="505" mass="56826" checksum="BEE4F8A1F3AA5DAA" modified="2015-04-29" version="1">MPRGPLRRSASITDLRFTLRRVFGKESFRPLQEEVIASVLEGNDVFLCAATSFGKSLCYQLPAVVSLGVTVVISPLLALMTNQVQAARDLGINVECINGRTPYQERVRIETDLLCGHPSTKLLYVTPELCATNHFRDLITKIHRQGQLVRIAIDEAHCISEWGHDFRPAYKDLIWLKTTLNCPTVPVMAVTATATPQVREDIFKFLGLVKTKTKIFSTSTARPNIHYEVQYFSESNPENGQDDVFPYLLSRLNFMHQRRLMRLQYLRKQDPKAVMAPITGIVYVSYRATADSLATKLSDAGIRAQSYHAGLEDAQRQKVQTSFLRFATGDPRLFQASGGTDMMSSFNVMCATTAFGMGIDIPTIRFVIHYGLPRGMESFSQESGRAGRDSKAASSIILYTREEKERSEFRARSDANREKSKAKAESRLLSLQSVVAFCENTSLCRHDLLSRYFGGSAGSAECRWACDVCKEGPTKLKKRKERGLATEHEAFEFTQRQGVQDYEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y5H2</accession>
    <name>A0A0D1Y5H2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Malate synthase</fullName>
            <ecNumber evidence="3 10">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_11142</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the malate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="3 10"/>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230397.1">
        <property type="nucleotide sequence ID" value="XM_016385453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y5H2"/>
    <dbReference type="STRING" id="91928.A0A0D1Y5H2"/>
    <dbReference type="GeneID" id="27338225"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11142"/>
    <dbReference type="HOGENOM" id="CLU_018928_3_0_1"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="11">
        <location>
            <begin position="164"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="13">
        <location>
            <begin position="415"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW10181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="542" mass="61568" checksum="BC36287C2D0F71B7" modified="2015-04-29" version="1">MASINTINDGVAINAPIKDSYRKILTPEATAFLALLHRTFNSTRKELLKRREVRQAELDRGVLPDFLPETRHIRDSDSWKGAPPAPGLIDRRLEITGPTDRKMVVNALNSNVWTYMADFEDSQAPTWDNQVSGQVNLYDAIRRQVDFKIGEKDYKLRTDRVLPTLIARPRGWHLEEKHFTVDGEPISGSLFDFGLYFFHNAHELVKRGTGPYFYLPKMESHLEARLWNDVFNLSQDYIGMRRGTIRGTVLIETILAAFEMDEIIYELRDHSAGLNCGRWDYIFSFIKKFRQNPQFVLPNRDDVTMTVPFMDSYVRLLIKTCHRRGVHAMGGMAAQIPIKDNAEANDKAMDKVRQDKLREVLAGHDGTWVAHPALAPIAAEVFNKHMPTPNQLFKRREDVSITRNDLLNTNLPGSVTEDGIRKNLNIGLGYMEGWLRGIGCVPINYLMEDAATAEVSRSQLWQWVKHGIKTAEGKTVDKAYALKLLKEQANELASKAPKGNKFQLAARYFEGQVVGEDYADFLTSLLYNEITTVGSSQPVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y6G9</accession>
    <name>A0A0D1Y6G9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_11430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230682.1">
        <property type="nucleotide sequence ID" value="XM_016385738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y6G9"/>
    <dbReference type="GeneID" id="27338513"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11430"/>
    <dbReference type="HOGENOM" id="CLU_083662_0_0_1"/>
    <dbReference type="OrthoDB" id="4119392at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="290" mass="32619" checksum="57A30A0226DECC2C" modified="2015-04-29" version="1">MPPFLPNVRSVSRSRHSGPRSIVYRTTDKSFILSNESLKKRTFKRGFGSSTTIFDLSASTDLTQLPLQTPSGEKGFDKSDMNRQGDQRDNLRDGSSGRPHKSGRKKEQQDLDDYDPLVSGMNPLQEIPILPIYDLIMVLQQRGITVRLTSAAVREAAAQGFINRSNAVNGDRISPEIERTSRQDTHNINVALTVLLNCGADIDFGPLVREHRPSSIKCTTCGETFANQREKDEHRVRRTCEYCDDDDPYTHNCQTKFDDHIRRTHNINPHRRMPSHSGSDAGWGGGGQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y754</accession>
    <name>A0A0D1Y754_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230952.1">
        <property type="nucleotide sequence ID" value="XM_016384350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y754"/>
    <dbReference type="STRING" id="91928.A0A0D1Y754"/>
    <dbReference type="GeneID" id="27337118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10035"/>
    <dbReference type="HOGENOM" id="CLU_049918_2_0_1"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="336" mass="38370" checksum="B8955A3E92393011" modified="2015-04-29" version="1">MASETASQSSNHSSSYSKYQIQQYLDLIKFPLDHDHLSGSLLEVPPEQQYDFLARLIRRQICSVPFENIGLHYSRHREISLDPSQLFHKIVEQRRGGYCLEINTFMALVLRGLGFDVISVGGRVSNQIKPDNKNKQVEYGGWTHMVNIVTIEDQRYAVDCAFGNNGPTRPVPLRDGFTCRNTGDNTNNSEMLLRHESISESSSTPKQLLWTYYVRFKASMQWIPAYCFGEIEFLPNDFRAMNFYISKSPESWFTQILVCMKFLEDPNTTSSTADQVIIGDITLRGDTVKERKYGQSRIIATFHGEADRIAALQTYFGIELTAEERMGISGMISQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y774</accession>
    <name>A0A0D1Y774_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_10060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230977.1">
        <property type="nucleotide sequence ID" value="XM_016384375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y774"/>
    <dbReference type="STRING" id="91928.A0A0D1Y774"/>
    <dbReference type="GeneID" id="27337143"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10060"/>
    <dbReference type="HOGENOM" id="CLU_012970_1_0_1"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="77"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW10761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="592" mass="65633" checksum="86DF8A10DDC4E3A9" modified="2015-04-29" version="1">MVSLTGKRPDKPWLKMRFKGLFGAGFRGVDRNDGSNHIDEENVNQPDDALISEDAQAGVQRVQAATTVWTTTHLIGAHFCIWFIYFVISLEEVVLRSLNPYVTSSFSLHSLTSATNIMSSIIGGLAKIPTAKILDTWGRPQGIGLMTFIWVIGYIMMASCRNVQTYAAAQVFSVTGAQGVSYCLTVFISDMSTLKNRSLMLSIATSPYIVTTWLGGPVSQNVIQGPGWRWGFGIFAIVVPVVVAPLTILFLYNQKKAQRHGLIGHTRVSLRPEALKRYAIEVDLLGIIILAGGMALFLLPFSLYSYQPDKFRSPMIICMIIFGGVLLIFFVLWEKFWAPKTFIPFELLMDRTVFCAGLMFVFVFFNSMVWGSYFFSMLQVVWGLNITNASYVSAIYRVGSCLWAVAVGFLIRWTGRFKWLALYFAIPLMMLGVGLMIEFRQPDSDIGYIVMTQIFVAFSGGTIVLCGELAMMAPSNQQHIAAVIAILNLFGSVGSAVGGTVATAIWTSVFPSALQKYLPPDVDAKKVYGSIIAQLYYRPGTPARDAINRSYAEAQRYMLITSLSLLGGAFICVALWRDIRIKDIKQVKGRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y7Q9</accession>
    <name>A0A0D1Y7Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_10250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231167.1">
        <property type="nucleotide sequence ID" value="XM_016384565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y7Q9"/>
    <dbReference type="GeneID" id="27337333"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10250"/>
    <dbReference type="HOGENOM" id="CLU_039184_0_1_1"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW10951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47813" checksum="CC15EF01B76118A1" modified="2015-04-29" version="1">MSGQKVLDVHTDPDPGAQETPGHTQSTPEVQKYTYTTLPGYFLQDDPETKPETFEFMKTNFGLVQLSYDSDENLPNGGRDATAWQRFENHIATLNRAEERKRHGSEEGSHTRYKLLFLGRHGNGYHNIAERYYGREAWDCHYSALDGDPENVMVWSDAHLSREGRRQAAEVNDFWNAQIRGEKMSLPQKYFVSPLDRAMETAQITFKGLLDKFDPTVMERLREGTGIHTCDRRSDVSYIRGRFPEFITTRDPLLTESDEFWDPDLREPDDALTTRLGELFDQLMRTSEGFRDSERVSFTSHSGAIGAILRFLGHRPFALGTGAVIPVFIKIETREDLDKRHGGEAEGGKHAKVDGDEVDVGEDDASLADTMAVDKSQWGRLPACPVDMDLNTVGPKRWNMDLKEFVAGVENGTVQIEEVAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y814</accession>
    <name>A0A0D1Y814_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_10380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231297.1">
        <property type="nucleotide sequence ID" value="XM_016384695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y814"/>
    <dbReference type="STRING" id="91928.A0A0D1Y814"/>
    <dbReference type="GeneID" id="27337463"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10380"/>
    <dbReference type="HOGENOM" id="CLU_351251_0_0_1"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF8">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="74"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW11081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="801" mass="89022" checksum="43409972EF66D61B" modified="2015-04-29" version="1">MTSKRLDDFQVQWSPSERQDFIVKPPLRQETPYSPVKYFFGWQESDSKGNIRPTGQRFLHLFSRGTELSDEEEWKFQRPLGKGSFGAAALFVKLDGTGKPIDNFVLKVADLKPNDRLSDKKIGLSREAAIMAQTNALGSDSIVRLRHFNVSDNYGRYYFEHCPHNCLESLRLSYKAWDMYLPEAFLWQVFCFLAEGCVKFDSGPFKNLASSRFGQDFPEAYLLHNDIKTDNILLGSNVKKDGSKEWYPVAKFADFGLFIITNRYEALRNTARFLQRGTKPWHPPEIRVAMMTDPKKYYFMQPGINPSQRDQHKILSKANIWAVGAVMWSLTSLGEIQNLSNQTDAILMGIFPLDGVNILQEFEGSVTRNYSPQLLGMIKKRLRMRTQDRPTAEDLFREVFSLRQECLEKETERANRTGDWHPLYLWCTPDELNELGSGEAISDDKDRSFWETTGATGYTGGQALHAIAASTPASQVSITCLVRSAEKGKVVQDAYPDYVKVVVGDLDDVEVVEKQSQKSDVVLQLADTKHMGAAHAIVKGLTSRSRTTGSPATYIQMSGDSLFVIPEIESKRYGEPPTTIWDDMAGQPEIIENIRAYPSREVDNYIISDASSTGIRTALVVGPLIYGTGPGPGNTRSIQAPEIARKTISDGSGFKLRKGLNVWSNIHIEDLGELFATLARTAGQGSSTSTGNTSSSAADLDIWGENGVYLPGNGDMSFGDLCEAVATEAHAQGLIKSATIDRTIDVDEANAAMPGGAIFWGTNAVYKSERAQILLGWKPSAPSLQDTIPEIVRVEAEKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8C7</accession>
    <name>A0A0D1Y8C7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF34</name>
        <name evidence="9" type="ORF">PV08_10546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231462.1">
        <property type="nucleotide sequence ID" value="XM_016384860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y8C7"/>
    <dbReference type="STRING" id="91928.A0A0D1Y8C7"/>
    <dbReference type="GeneID" id="27337629"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10546"/>
    <dbReference type="HOGENOM" id="CLU_043845_0_1_1"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW11246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="336" mass="37684" checksum="1A70F49F1EA5CA6B" modified="2015-04-29" version="1">MRPTLLQGHERSLNQIKYNSDGDLLFSVSKDKVICAWFTSNGERLGTYTGHQGAIWTVDVSPNCELLASGSADNTIRLWNVRTGENVKTWEFPTAVKRVQFSEDGKQLLGVTEKRMGYLGTIVVYDVRYGDDLTDQTNEHSLRITCEDSKATVAGWSYLDKYIISGHEDGTVTQWDAKTGENLMSVEAHEYDTAINDLQFSPDRTYFITAGKDKTARILSTRDLSVLKTYVADTPLNTAAITSKKDFVILGGGQAAMDVTTTSARQGKFEARFYHKIFEDEIGRVRGHFGPLNTIAVHPQGTAYASGGEDGYVRMHVFDKSYFDFMYEVEREQARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Y8G3</accession>
    <name>A0A0D1Y8G3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231502.1">
        <property type="nucleotide sequence ID" value="XM_016384900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Y8G3"/>
    <dbReference type="GeneID" id="27337669"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10586"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="502" mass="53546" checksum="D72B9845E8DCA7E2" modified="2015-04-29" version="1">MALNGSILATAIPQITTHFRSLEDIGWYGSTYLIATACMQPLVGKIYTHVPIKQTYITFMATYTVGSAICGSATSSKMLIGGRAVQGVGGAGILNGAFTVIASTAPEDQKPIFTGVGIALSTVGQVVGPLIGGVLTQNISWRWCFYISLPPAGVVLLVLTTVTIPEQTEKKPLKSNWKKLVASELDLIGFALFAPASVMLLLAVIWGGGKFAWDSATIIGLFCGSFVEYLIFAAWQWHRGEKAMIPPHVIGKRLVLAGCATNFFQMASNMTLSYYLPLWFQVVKGATPTLSGAYILPTAISQSIGAVVAGKIVQVLRYCTPWAIFGSIVSTIGSGLITTFTPTTSTGKWIGYQILIGTGRASVFQMPITAIQAFLPRKEQAMATSQVFFCQYLGGTIFLAIAETLFTSSLRSALHRDAPGVDAEHIIDVGASAVRSAVSPADLPGVLKAYNHAIVEDFYLAVGGTCGAFLACFGLGFEKLPQKEIIKKGEEIDLRRTESNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCT8</accession>
    <name>A0A0D1YCT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016232982.1">
        <property type="nucleotide sequence ID" value="XM_016382279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCT8"/>
    <dbReference type="GeneID" id="27335036"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07953"/>
    <dbReference type="HOGENOM" id="CLU_2622056_0_0_1"/>
    <dbReference type="OrthoDB" id="4790282at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="78" mass="8847" checksum="544A69F6D9EE9DBD" modified="2015-04-29" version="1">MESYNKDDKGDQDRVLPSNQAEKPVGAHTEYVLDPEGEKSISVDYSGAHEKTDPAEIALIKKLDRWIISNGRVNSYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YCW3</accession>
    <name>A0A0D1YCW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_07988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233017.1">
        <property type="nucleotide sequence ID" value="XM_016382314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YCW3"/>
    <dbReference type="STRING" id="91928.A0A0D1YCW3"/>
    <dbReference type="GeneID" id="27335071"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07988"/>
    <dbReference type="HOGENOM" id="CLU_015118_0_0_1"/>
    <dbReference type="OrthoDB" id="5345392at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="402"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW12801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="591" mass="65184" checksum="50002E3C71F896A2" modified="2015-04-29" version="1">MDPEALKASLLDVVVPQDTTTDLAELLETYSETTNDTGRLVTIKERDTLFFDEKLRTLAILQVPHCDEDVLKAFLARLSYKVDAWALDESISNEPPATPSTPARDLVSSYEGIQESEPLVLASQSSDNARILTLIWEIQMPLNRPRFRLPQPSIVFIPSATISPQQQDENRKDDDLTPFQPLEANILEPMRFIPGFQQHPPYLAASRLERVLPLTAPHKSRLHIQHVPSRRYRAVPAAVARIRYNRINALSPVPTNMALLDIEIVPFVQIDATVEVVELALKSGRVEPIMVDFLPIQCHSGDCITIIHKLQQGLSTSDSPGTSLVNPNIDILSIRVRLSVHSSEECRPTINMEWTTHVDFSQALNPSFGPPSQPIQRPNRPTSLPTVTSNDNSLPPIDNALSLRPASDVLARSGLSISFTAPEGAVEVGVPFSWKVIVVNNSLKVAKITIIPLPRMQRQTTQAQSMAKRHAPKSSTASFHPSERRHTQNEDGVDIAQAIVDENVVYAMHHSNTVPPETDLMALTAELRVGPLGPGQCHESEIQMVAFDTGSLRVDAMRIVNLIREAEQGTATPGVLVDIKDLPTVLATKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YE83</accession>
    <name>A0A0D1YE83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_08589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233617.1">
        <property type="nucleotide sequence ID" value="XM_016382914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YE83"/>
    <dbReference type="STRING" id="91928.A0A0D1YE83"/>
    <dbReference type="GeneID" id="27335672"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08589"/>
    <dbReference type="HOGENOM" id="CLU_067596_0_0_1"/>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="72"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW13401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="233" mass="25809" checksum="5CFA181F33FCD6DE" modified="2015-04-29" version="1">MSRFVPAGTDPGSGSNEKEDDAWTKARQQIEALKKPKPVDEGKQEGGESLYDVLQRNKGKDRFLTPCTFASTAAKQEAFEESIKLKNQFRALDDDEVDFLDSVLESERAKEDAVKKEMSEQLEAFRNQRAKAEKDLLEHEIPEAEERLGAPVGKNAWTTQKKRRRRDEESKAIASNKTRKLSSSADNTPQQPTAPKESGELAKPLEAANQSSPAQVKSTPGVLGLGDYSSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YFA1</accession>
    <name>A0A0D1YFA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_08967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233992.1">
        <property type="nucleotide sequence ID" value="XM_016383289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YFA1"/>
    <dbReference type="STRING" id="91928.A0A0D1YFA1"/>
    <dbReference type="GeneID" id="27336050"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08967"/>
    <dbReference type="HOGENOM" id="CLU_1015632_0_0_1"/>
    <dbReference type="OrthoDB" id="5353914at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW13776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="309" mass="34341" checksum="E91C5311B48CC4F9" modified="2015-04-29" version="1">MLKAHKNTRKATPDDQIRFLIACCKHSNYGRIDHAAVATDCGITSKGASAKRYERLLKAYSTPEGTCEVADPDDDADDDEVPMAALAHKRKATDDDLVEARSTKKQANNRQFMAPSTVKASNITAPDITRASLKSQVPPVEQRKTKTAAPVRLPNHLPARPPSPRPSSQRTTEHMLFPDIPPAYFAPMPSAHYPPPYTHLMPSFPPSRYDYFSPGRVPSPDVPRDFVRRYQEANSMLRGDDHDLDRHSSGELFKPVIGERYPIRLKPQAPPVQGHGAVDHQPKIPPPPQEVQPAPAKPMAEKEDFNSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YFC4</accession>
    <name>A0A0D1YFC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">(S)-ureidoglycine aminohydrolase cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234007.1">
        <property type="nucleotide sequence ID" value="XM_016383304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YFC4"/>
    <dbReference type="GeneID" id="27336066"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08983"/>
    <dbReference type="HOGENOM" id="CLU_141740_2_0_1"/>
    <dbReference type="OrthoDB" id="4985585at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="1">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW13791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="120" mass="13040" checksum="9370C21F8973DF95" modified="2015-04-29" version="1">MGLEVIPKTAKFKAQNIEGAPPHVYFTDFLGTRDEKVPNPIVGAWFRIEKGTPATPPKYEYDEVGVVIEGTITLKDEDGGAETTVTIGDSFVIHRGSTIAFSSSDYGIAFKCGSRLMARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YGQ6</accession>
    <name>A0A0D1YGQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein TSR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234387.1">
        <property type="nucleotide sequence ID" value="XM_016381285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YGQ6"/>
    <dbReference type="STRING" id="91928.A0A0D1YGQ6"/>
    <dbReference type="GeneID" id="27334035"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06952"/>
    <dbReference type="HOGENOM" id="CLU_074896_0_2_1"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW14171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23664" checksum="F681D52E89B74D6F" modified="2015-04-29" version="1">MSAVSVNGPQAVSQFDLSKLSSQIDLLVALHLWSWPALTLAIQNAWGGSAQVSNDKRDWMAGAVSELLISTPPALADVGDLEEVLLQVMVDEFEIVVDDGTAEDVARSIWSGATKIRNGDLTELNDLYIRWQEKQQKGGDRIVNIVRGEDKDQDTDADEDDYEDEEEWNGFEDRQDVDMDDAPPLTGSRMPKQKAEPEVDEDGFTKVVGKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YGS8</accession>
    <name>A0A0D1YGS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PV08_06982</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="11"/>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234417.1">
        <property type="nucleotide sequence ID" value="XM_016381315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YGS8"/>
    <dbReference type="STRING" id="91928.A0A0D1YGS8"/>
    <dbReference type="GeneID" id="27334065"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06982"/>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="16">
        <location>
            <begin position="37"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="17">
        <location>
            <begin position="301"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KIW14201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="422" mass="44107" checksum="B6A7B83B7024C10D" modified="2015-04-29" version="1">MAQSPNKAQERLSQVSSHLGGSPSLHKSILSKSPDDVVVTCALRTPFTKGGKGLLKDTAAADLLALTFKNLLERSKIDPALVEDIATGCVLAPGGGATEYRAAALVAGFPESTAVKSLNRQCSSGLQACVDIANAIKSGMIEIGVGSGVESMSSQYGPGAVTEFSELLEDHMQSANCKVPMGVLSEQMAKDRNISRADQDAFAASSYQKALKAQQAGLFDEEIAPITVKYTDPKTEQEKTVTVTKDDGVRPGITPESLGKIRPAFAKDGSIHAGNASQVSDGAAAVLMMKRSTAERLGQPILGKFVAASVVGVPPLLMGIGPWKAIPVALEKAGVSKDEVDIYEINEAFASQAVWCVKELGLPFEKVNPKGGAIAFGHPLGCTGARQVSTLFTELKRTNKKIGVTSMCVGTGMGMAAVWVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YJE7</accession>
    <name>A0A0D1YJE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_07863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW15076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235292.1">
        <property type="nucleotide sequence ID" value="XM_016382190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YJE7"/>
    <dbReference type="STRING" id="91928.A0A0D1YJE7"/>
    <dbReference type="GeneID" id="27334946"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_07863"/>
    <dbReference type="HOGENOM" id="CLU_013291_0_0_1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW15076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="869" mass="93389" checksum="AAC8BFC3B560136D" modified="2015-04-29" version="1">MPSSQSSDQPLPAFGIRDLNGCGSPPGIVQILAKDYASTITTWPEAILTYVDDDDGEIIVVGSSFELTQRLEEPVRHSNLPAIPALRTPDEPADNKLMHIFDIKKSSASLSVWKDFEAYTSKVIREKTTPESLRSVSPSESAASPALPATQQKVQQSDKIEGSVGSASSLAGAAVTTQTVADNTTVSPIISSATVNKTTPGPSNNDGPTNLDKAFIGIFSAIESKLGPLADFLETTADGLRKVADKTARSDSSAVEDILGGFKDILTQVGEFGLGVAATIGEEIEKNKAKQHDASVQSDEGRAALPTGDDTGASAQPEQVKPSEKVDVLGKKVCFVPPPRSSATIPALSRMNAPNRQQMKQMIMDWRPSGARYGGFLQDDRVHTAQQPDKATVRHSIMDMESADPDFSTRYPPLLSLRKAKSVNGLQNPSQVAGSSQPNPVTGPASVRYPSLKQFEQQAHNIAFNKTSGSLAGTRPRNVASREDELLPKKTALHKKPSVEEGDGSDEPGASTVKPTPSSLRDTTPSGPLPGAWPETKPAEDMSALPTTRTIINGGSRRPPKPDLFAMPQTNPTGYPRPQLRPPPDFSPRPSMTWTALEEKLRRNHTVSGINPAARLNGPFDPLAHHSPTQPRPQQSQPDLKKSYRSSEHTLDHKPSLPSLLPQRSHTVNYTDRYVPRYVTPSVYLDRARDYAESRNNARDHRIDGNHMPGPSWGVRYFSPFGQPATTAASSARTPSATTGEGHSSSDVKAKLLSAARPALEPRPSIVPPVQRATTKPAERGISRSTPPITLPSSVKAVNECVKALIDMGFGANPDEMTRLNAVAGATAGNLEEAIDMLEEDREATEQLAYANDSATHGSAQDEREDMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YKZ5</accession>
    <name>A0A0D1YKZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_05756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016235922.1">
        <property type="nucleotide sequence ID" value="XM_016380095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YKZ5"/>
    <dbReference type="STRING" id="91928.A0A0D1YKZ5"/>
    <dbReference type="GeneID" id="27332839"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05756"/>
    <dbReference type="HOGENOM" id="CLU_006368_0_0_1"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="520"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="833"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="895"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1038" mass="114782" checksum="405F0FAA96B9B913" modified="2015-04-29" version="1">MAGMLESDRARSRRERTFVGGECAACEELLEHTLRGERILQFSCGHVAHEACFYEYIKDSDAQYCPVCDAPLGLDSFRGGSILDLSKLSNMVRAVAQKDVTSPRSSQNTPMPWDRQTTQGQEDSFSTRDLASREMSTRNSRENPNRDSRDSQRMRIERLGIGQAAANGQRGPLQAPSTMTKNTSHTRNDSGGNNSSTDDANDHLSHSRKHDYDLHAMETTVSGSQLKDAKQTIPSPIVTVRSEYPTLTRSRQQQSLTCLVTIEVPELKWLPQLEEVQTPPVPPLPTDSGISMPGRQRPELTPDHLAYETPEVLEEKTEELRIRVDNWHGLEFQRFGNLRLHGTVRVGKDRHSWQELECYLFGEMLICVKEKKNSHPPVILESGRKLTRCTLKGSILIKRHLRQVHASLDENILTLNLSVAELPTFHLLFQEREKLELWQKALRDLNSSDSLSNYPQDYEQDTSGTDDDEYGRQNRTVRRVPSMTSSYGGPKSATTAATEYSMQRAVVDRKIPPSLHVPIDVVVVIPVSSSMQGLKISLLKDTLRFLVSNLGDRDRMGLVTFGSSGGGVPVVGMTTKTWQGWNKVLNSIRPVGQKSLRADVVEGANVAMDLLMARKAANPISTILLISDSTSSDSDSVDFVVQRAEAAKVGIFSFGLGLTHKPENMIELSTRTKASYLYVKDWMMLRECAAGVLGALQSMSHQNVKLKLKLPEGSPGKFVKINGALQTTKRSTGRDAEATLGDLHFGDKRDILVQLAIDPDISSQEPAPQDPWESIVSGLEALGGSLDTEDQRVQSVEEVPLLQADLSYGDLLKDGSIMQLPRPSLLAITMLPAHPQSRSSSGRPSSPPIPPHPMIVQRRMELLTSDMLSRALTLVARGQHERAHHLLNETRTILKGLGKGGLPPLPPGPPAMNKRHSPPAKASSPRSETSVSMGVRDQSPHSDSSTPIPRTTGVDLATMNALDADIETSLEWINHPAVFSRDSRKAVLQAIGVISSQRAYTFRSASESIWAERLPGVKRLTDQSREWREVGDDALTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YL93</accession>
    <name>A0A0D1YL93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_05861</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="12"/>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236027.1">
        <property type="nucleotide sequence ID" value="XM_016380200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YL93"/>
    <dbReference type="STRING" id="91928.A0A0D1YL93"/>
    <dbReference type="GeneID" id="27332944"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05861"/>
    <dbReference type="HOGENOM" id="CLU_035267_0_1_1"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="351"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW15811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="414" mass="45592" checksum="941E0BEEDB41042F" modified="2015-04-29" version="1">MAGRELSPEEKLSLVTDQLAEVLHKDILEDVILKQQRPLVLYWGTATTGRPHCGYFVPMMKIAHFLRAGCHVKILLADIHGFLDNLKAPIELVKYRAEYYKFVISSLLKAVGVSLEKLEFVLGSSYQLSSDYTMDVFRLSSVVTEHDAKRAGAEVVKQSENAPLSGLIYPLMQALDEEHLKVDAQFGGVDQRKIFALAQETLPRIGYKERAHLMNPMVPGLTGGKMSASDPDSKIDVLDGPELVKKKLRKAYAATGEVDGNGIISFVEYVLLPFSALQDPNHKGTFVCERREGEGEPLVYHDMETLKADYKADKLTPQLLKAGATAALNELLAPIQADYQASPEWQEIEQKAYPPAEPAKKKKQPKNKGTRYPGAGNVQANPDGTVTGEGKEQVEVGKTAEDAMSKLEIEGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YLP5</accession>
    <name>A0A0D1YLP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_06001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847495">
        <property type="protein sequence ID" value="KIW15951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236167.1">
        <property type="nucleotide sequence ID" value="XM_016380340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YLP5"/>
    <dbReference type="STRING" id="91928.A0A0D1YLP5"/>
    <dbReference type="GeneID" id="27333084"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06001"/>
    <dbReference type="HOGENOM" id="CLU_063282_0_0_1"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW15951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="264" mass="27500" checksum="5B720A803D8A21AD" modified="2015-04-29" version="1">MVDYAKKTVAELQEILKSRSLPHTGKKAELVARLNEADQAAAENEALKAPPAESTTAPPAQIPEPAAPSTSEAPEADQPGPTAAEPATVEPTAANDDSAQATAASFALNLPTSEVDAEMAKRKARAERFGTGAAVANGETGAVGTEGADAEALKALERAKRFGTGQTAMGKLDEALPSDSKRDSRKRGRTEEDSTMDDPGLRRGFGGRGRGGGRGGRFQGRGRDNSQRRRGDRPGGVSKPFGAFSTEADRLAAEARKKKFASAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YNB1</accession>
    <name>A0A0D1YNB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_03734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW16546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016236762.1">
        <property type="nucleotide sequence ID" value="XM_016378085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YNB1"/>
    <dbReference type="GeneID" id="27330817"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03734"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW16546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27108" checksum="F1867B852977E090" modified="2015-04-29" version="1">MPAPTTLTVGASRGLGLELVKQLSKTPDQHIIATVRSPTDRIPKSDNITLLILDQSSPESVLAAASHDVELDTLINNAAIGDDELLLRTTESRLFEYVNTDILGPIQIVKVFLPALLACRTRKVVFISSEAGSLSLQVDINFGFRGPYAVSKAAGNMVVVQLHNELREEGFKVVAVYPGIAGDGGMAPGESASQASKVIQKLQARDSTRLFNYDGTIVPWEGFMLRLRCVLIRAGVFTKAKVCCPREEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YPI4</accession>
    <name>A0A0D1YPI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_04287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016237312.1">
        <property type="nucleotide sequence ID" value="XM_016378635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YPI4"/>
    <dbReference type="STRING" id="91928.A0A0D1YPI4"/>
    <dbReference type="GeneID" id="27331370"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_04287"/>
    <dbReference type="HOGENOM" id="CLU_126103_0_0_1"/>
    <dbReference type="OrthoDB" id="4159978at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22958">
        <property type="entry name" value="DD_DPY30_SDC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="183" mass="19653" checksum="759EF5D2AACD7671" modified="2015-04-29" version="1">MSQSAPSVPSVVVNSQTSRQQVPLRDYLNARVAPFLKKAITESLGVEAEFPLQWLGECLIHQSILYEGNPDRTNIRERFQYKFEDPQPPEQSAQAQAQQEPPQAPPESVPEAAQPEVPPQAQSEATMTEDVPIAGQEASTVSEVPTEPTISTAEAPVVNGTSGLDTATPGDPKDDDTEMGGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRD9</accession>
    <name>A0A0D1YRD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_05021</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RCF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238042.1">
        <property type="nucleotide sequence ID" value="XM_016379365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRD9"/>
    <dbReference type="STRING" id="91928.A0A0D1YRD9"/>
    <dbReference type="GeneID" id="27332104"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05021"/>
    <dbReference type="HOGENOM" id="CLU_087356_0_1_1"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="11">
        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW17826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="217" mass="25295" checksum="F608DD22EDBA5B97" modified="2015-04-29" version="1">MSNPNATEPSPLSETTIPSSFDNEFFEESRFQKFSRKLRQEPLIPIGCAATCYALYMATKSIRAGDHHQTNRMFRARIYAQGFTLLALVAGSYFYKDERLKRKAFEAALDEKKTAEKREKWLRELEARDEEDRAWRDRIEKASADARAGVQDVKQSTERFLDEGKDSLKQQIAPEQTEQKKKSSWNIWSRSVKDEVVLDGWGPGMWATRTRDAWRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRH1</accession>
    <name>A0A0D1YRH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_05051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847494">
        <property type="protein sequence ID" value="KIW17856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238072.1">
        <property type="nucleotide sequence ID" value="XM_016379395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRH1"/>
    <dbReference type="STRING" id="91928.A0A0D1YRH1"/>
    <dbReference type="GeneID" id="27332134"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_05051"/>
    <dbReference type="HOGENOM" id="CLU_539715_0_0_1"/>
    <dbReference type="OrthoDB" id="5388486at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW17856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="54958" checksum="D6F7229FA1DA2B37" modified="2015-04-29" version="1">MATDASSISITPTSLRGSPSDRIIKPRPRKDSLQSISGSDTHPGRVVKPRARKSPGSGAKRSEPAKRKFICSFSHYGCDVALSSKNEWKRHVSIQHLQLGFYRCDVGSCNPDLNSNIPGHKRVYNDFNRKDLFTQHHRRMHKPESGPGSANFPPNGGDPKDWRAFEDSLEDVRSRCWIEKRKPPQRSTCGFCGRVFEGEGSWNERMEHVGGHFSRDIVEAKEEREDEDLTNWALAENIIKDAGNGRHVLVDQPPTAAERPYLSRDRDVTMTDAPSSDGYSRDPAESPSLSASSRRPESERGDYYPSLDSPREPRRLSNALPSANGTPRAPSVPLLSATPGSQSVIPTDPALTALGSPTSPSAQLQPTPTSPDRKAGYNLAPPPLKGPKPDGESSSGDRLEDLINQLIKPKGPKTHRRLTWKCDCAVEMSVDLDEADQQTIKNLQEISIVCSKTSNPYLKASKHGKYQVIGCDELASYIWKNTKQPIDQPNKPTEVAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YRZ4</accession>
    <name>A0A0D1YRZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_02277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW17991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238207.1">
        <property type="nucleotide sequence ID" value="XM_016376637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YRZ4"/>
    <dbReference type="STRING" id="91928.A0A0D1YRZ4"/>
    <dbReference type="GeneID" id="27329360"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02277"/>
    <dbReference type="HOGENOM" id="CLU_020027_11_1_1"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="13"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW17991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="389" mass="43201" checksum="B326869EE6A15AE3" modified="2015-04-29" version="1">MEELFETACSNSDIRGAVLVAASADDTFQYQQAFGRASSESDLTLESTFWIASCSKLVTSIAALQCVEKGLVKLDDDVTSILPEIKDIDILRGFDESLGRPILGKCQNTVTLRGLLTHSTGLGYAFSNPLLIRWRAYQNKSTALPASEFEKNYFMPLLHEPGESWVYGTGIEWAGILIERIVGTNLQSYLQQHVWDPVGVKDMTFHLEQRPDIQARLSCMSVRLSSSKIDWTTERVVPDPIHHELGGVGIYSTALDYLKIMKSILANDGRLLQGQTVDEMFRPQLTSNSAKALCDLVAAKETSTGFGVPQCVSVDHGLAGMLILEDIQTGRKSGSMSWGGYPNLKWWIDRKTGLCGLYASQLIPPGDAMSVKMYEIFQAEMYKRFSMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YS52</accession>
    <name>A0A0D1YS52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_02333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238262.1">
        <property type="nucleotide sequence ID" value="XM_016376692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YS52"/>
    <dbReference type="GeneID" id="27329416"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02333"/>
    <dbReference type="HOGENOM" id="CLU_072455_1_1_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43036:SF2">
        <property type="entry name" value="OS04G0481300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43036">
        <property type="entry name" value="OSJNBB0011N17.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW18046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30197" checksum="41AAF3A745C5899D" modified="2015-04-29" version="1">MPRALSKRNLPSISILSGVLPTSRRMEDASVRVRSYIPADPDGPFPYLPTDLTPQDAGDDSGFYAAPRFVTHIDDNAINTLRKYYQQVIPRKGRILDFCSSWISHYPREVVQAASLEELEVLGTGMNERELEKNPVLTHWAVQDLNQDPEVRLAGTDDRKLDAATCVVSIDYLTKPVEVLQSIRRRTKSGGKIHLIISNRCFPTKVVARWLKVDEDERLHMVGDYLWWSGWREIEIQTLVAGSFMHDPLWVVRAVNETGKAEEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YSW3</accession>
    <name>A0A0D1YSW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238597.1">
        <property type="nucleotide sequence ID" value="XM_016377027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YSW3"/>
    <dbReference type="STRING" id="91928.A0A0D1YSW3"/>
    <dbReference type="GeneID" id="27329752"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02669"/>
    <dbReference type="HOGENOM" id="CLU_025894_2_0_1"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="25"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="480" mass="51490" checksum="A62AEB6BFF917EED" modified="2015-04-29" version="1">MTNEQEQGSNGSTASKVLRPLRAVLNELGLVTLFHASTDTKILILQRFVRLFAYGGSTLILASYLSDLGIADARIGLFMTLTLIGDVFISFLLTLVADQLGRRWILVLGAALMSVAGIVFGLSGNYWVLLAGAIIGVISPSGNEIGPFRAVEESTLAHLTASADRSDIYAWYSLIGTAGTALGFVSCGWIITFLRDEKHFSSIKAYRVIYLIYTIVGLIKLCLALLLSKECEVNTQPKAANPSETSPLLGDSGAAAQKKKKRWNLLPDISKESKVVLIQLCILFAFDNFASGLAPVSWVTFYFKRRFNLSEGNLGSIFSVTGVISALSMLVASSISKRIGNVKTMVFTHLPSAICLALIPIPSTLAGALVFLIGRSCTQVMDVAPRSAFLAAIVLPHERTAVMGTINVVKTCAQSLGPVITGVLGTKNHFWVAFVAAGSLKATYDLGLLALFAERKSRENKVAQPSDEEQQDNNGGNSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YTI5</accession>
    <name>A0A0D1YTI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PV08_02809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238737.1">
        <property type="nucleotide sequence ID" value="XM_016377167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YTI5"/>
    <dbReference type="STRING" id="91928.A0A0D1YTI5"/>
    <dbReference type="GeneID" id="27329892"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02809"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KIW18521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="262" mass="27849" checksum="47B769113A95B433" modified="2015-04-29" version="1">MAPFTHHVVIITGAGSGIGRATSIRLASAGANLALSDIDSGGLETTLHLCREAAAADLTPDDANVQRHMASSVDIRSTEAVNAFVASVADRHQGRIDHVFNCAGINPTNLPTEHISDEYWQRLVDTNLKGTFAMTRACIPHMRRGGSFVNVSSVCGLYPTAGFAVYCATKYAVIGFSKCMALELGERGIRVNVVAPGIVETPTNVAFRAGSERVQKLAKEIGLKRTGTPEEIADVVAFLFSEESRFMNGSVVEVDGGIGIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YTS1</accession>
    <name>A0A0D1YTS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_02940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW18651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016238867.1">
        <property type="nucleotide sequence ID" value="XM_016377297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YTS1"/>
    <dbReference type="GeneID" id="27330023"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_02940"/>
    <dbReference type="HOGENOM" id="CLU_2026757_0_0_1"/>
    <dbReference type="OrthoDB" id="4146045at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002247257" evidence="1">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW18651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="122" mass="13016" checksum="BE8CDB7AE66EDB47" modified="2015-04-29" version="1">MKLTAFSGVVVAALFSLAFAGEPGEHDANDSCYNTCEANKGVKDGLHISSPACPGLTGDLCKKSCWCDTSKSHPEGVMGCNNKKLPSCSADAILKTCKAGLPNAWHCWCQGTWNDWGKDCDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YUW7</accession>
    <name>A0A0D1YUW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PV08_03341</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="KN847493">
        <property type="protein sequence ID" value="KIW19051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239267.1">
        <property type="nucleotide sequence ID" value="XM_016377697.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1YUW7"/>
    <dbReference type="GeneID" id="27330424"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_03341"/>
    <dbReference type="HOGENOM" id="CLU_000524_5_2_1"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
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    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
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        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_bsu_CS"/>
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        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
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    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
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        <property type="entry name" value="RNA_pol_Rpb2_3"/>
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        <property type="entry name" value="RNA_pol_Rpb2_4"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="83"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="329"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="544"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="643"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="748"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="824"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1198"/>
            <end position="1290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
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            <dbReference type="RuleBase" id="RU363031"/>
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            <dbReference type="Pfam" id="PF04561"/>
        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KIW19051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1294" mass="146968" checksum="970AC384328ED712" modified="2015-04-29" version="1">MPSLRHAFWRFIPESRSRRRYLSKFPDGLDNFILSSPSYLACTVKMEKYEDVGDYYGEEVVDQDITSEDCWKVISSFFDIKQLASMQIDSFNHFMRSGLQDLVNEKGGVTLDHAQNVEDDDPNPIVIKRHEVKFGKVTLSKPNMVEGDGTTTDCMPHEARLRSLTYASPVYVKMSKKTWYAKERPWDDQSADQGVMRDDGSELFWREGFEEGDENQEEDVYIGKIPIMVRSMTCHLKGERFQSDKDLFAWGECPYDQGGYFIINGSEKVLIAQERSAGNIVQVFQKAAPAPFTHLAEIRSVIDRGARMMSQCTVKLFRRVDGPDGTKIDNPIRVQLPYVKQDIPLVIVFRALDIVSDADILEKICFDQSDKEMLDMLMGSLQEGQPIQSADLARDFIARRGNIPTLKSHERQKHAIDILQKEFLPHIGQGPDVATKKAFFLGYMVNRLLKAALGRAEPDDRDHLGKKRLDLAGPLMTNLFRLQFDKATKDFFRYMQKRVEAGQPISIHAGFKHPIITSGLKYSLATGNWGDQKKLDKAKAGVSQVLSRYTFASTLSHLRRTNAPIGREGKIAKPRQLHNTHWGYVCPAETPEGQACGLVKNLSLMSMVTNSYETEPLRAYVLNKHVDAIEEWEPRLNPQATKIFIDGVWFAVVLRDPKRLVDDLRRLRRQGTFDAQVSLVWDIREKEFRISGDSGRIIRPLFVVETDKASENVGNLVLNKEHINKLDQTNYLKESGYQFNDEVSAYGWDDLLKAGVVEYLDAEEEETAMIVMTPEVLADSKARWLGMEIENFDDPLGRNEPLLTPNSHSFTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNFDQRMETMANILYYPQKPLARTMAMDYLKFRELPAGQNAIVAIACYSGYNQEDSVIMNQSSIDRGLFRSLFYRAYQDQEKSVGHAVVESFEKPTRADTLRLKHGTYDKIDEDGIVAPGVRVSGEDIIMGKTAPMAPDAEELGQRQKQHVKRDVSTPLRSTESGIVDQVMLTTTNDGHRFAKVRVRTTKVPQIGDKFASRHGQKGTIGITYRHEDMPFTREGIVPDLIINPHAIPSRMTIAHLIECQLSKVATLRGEEGDATPFTKVTVTQISDILRKMGYQSRGFEVMYNGHTGKKLVAQVFLGPTYYQRLRHMVDDKIHSRARGPTQILTRQPVEGRARDGGLRFGEMERDCMIAHGASSFLKERLFDVSDPFRVHVCDICGLMTVIAKLKKNTFECKNCNNKNKISQIYLPYAAKLLFQELWSMNIAARLYTKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YWP0</accession>
    <name>A0A0D1YWP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PV08_00295</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 11"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW19721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016239937.1">
        <property type="nucleotide sequence ID" value="XM_016374661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YWP0"/>
    <dbReference type="STRING" id="91928.A0A0D1YWP0"/>
    <dbReference type="GeneID" id="27327378"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00295"/>
    <dbReference type="HOGENOM" id="CLU_013524_2_3_1"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="26"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="205"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KIW19721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="510" mass="58473" checksum="FE33EDFE5B310E4F" modified="2015-04-29" version="1">MADTVVRPDEPDNAGTVELKENTVIVVLGASGDLAKKKTFPALFGLFRNKFLPKDIKIVGYARTKMDHAEFLKRVKSYIKTPTKEVEEQLEQFTSICTYIAGQYDQDEPFQKLDKHITDIEGGRKENNRVFYMALPPSVFLTVSQHLKRNCYPTGGIARIIIEKPFGKDLNSSRQLQRGLEPDWKEEEIFRIDHYLGKEMVKNLLILRFGNEFLGATWNRNHIDSVQITFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQVLTLLAMERPISFSAEDIRDEKVRVLRGMPQIEPKNVIIGQYGKSLDGTKPAYKDDDTVPKDSRCPTFCAMVAFIKNERWDGVPFILKAGKALNEQKTEIRIQFKDVTSGIFKDIPRNELVIRIQPNESVYLKMNSKLPGLSMQTVVTELDLTYRRRFSDLKIPEAYESLILDAMKGDHSNFVRDDELDASWRIFTPLLHYLDEKKDIVPMEYPYGSRGPAVLDDFTASYGYRFSDAAGYQWNTASTPNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1YXT5</accession>
    <name>A0A0D1YXT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efflux pump dotC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_00656</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B. One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016240297.1">
        <property type="nucleotide sequence ID" value="XM_016375021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1YXT5"/>
    <dbReference type="GeneID" id="27327739"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_00656"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="95"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="592"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW20081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="626" mass="68132" checksum="948D1AC9370E4729" modified="2015-04-29" version="1">MTNQDNMTDTTLVTAGNREQSDHDVSDNPHAAANEGFYSVEAPSSPSNSLPNSEKPAQPDTRSSDDAQAEQATKPQLTRQESRADSFSRSRIIVIMFSLCMALFLSALDVTIITTALPTIAEHFHASTSGYTWVGSAYLLANAASVPLWGKLSDIWGRKPMILFANVIFMAGSLIAGVSNSMGLLIGGRAIQGVGGGGLVILVNICIADLFSMRDRPKYYGIIGMVWAVASGVGPVIGGAFTQGVSWRWCFYINLPLDGLSLVLLTFFLKLETPRTPFWDGIKAVDWTGVALIVGGVVMFLFGMESGGVGHSWDSAYTLCLIIFGVFTIVLFFFNEWRFAKYPVIPLRLFKDGSNLASLGVCFIHGFVFIASSYYLPIYFQSVLGAKPILSGVYLFPLVISLSFMSAAAGVFIKKTGRFREPIWFGLVMMTIGYGLLIDLDPTANWAKIIIFQIIAGVGVGPNFQSPLIALQSHVKGHDIAVATATFGFVRNLSTSISVVLGGVVFDNELAKKQTYLVNHGIPTQMAKRLTASGFSATANLLKALQPTQRRAVDIAYTSSLQKMWIFYTAFAAFGIFISLFITKKTLSKEHEKARTGLAEQERVRQEELAARQARRGTLDGEKDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0A9</accession>
    <name>A0A0D1Z0A9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_01570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW20991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241207.1">
        <property type="nucleotide sequence ID" value="XM_016375931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0A9"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0A9"/>
    <dbReference type="GeneID" id="27328653"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01570"/>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW20991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="443" mass="48417" checksum="2E5DB93D6136BADC" modified="2015-04-29" version="1">MSDLDKAIAQLRACRPIPEPQVRELCYKARELLIEEGNVVTVDAPVTICGDIHGQFHDLMELFRVGGDVPDTNYLFMGDFVDRGFYSLESFLLLLCLKVRYPDRITLIRGNHESRQITTVYGFYDECIRKYGSANVWRYCCEVFDYLALGALILGATTDVPPSTSQSFNDNTQSTLPPDDDDDVESEVLNANGDLISKTLRRQFAGLNLNSQSSVNAGRISPAPDMDVPSPLDPTSSLPSQGSPGASLFNPPTSTTGAVLCVHGGLSPLIDTVDKIRLIDRKQEVPHEGAMCDLLWSDPDEIEGWGLSPRGAGFLFGADIVRHFNHTNDLSLIARAHQLVMEGYKEMFDKTIVTVWSAPNYCYRCGNVAAILELGEDGSNGGCITRANGDQGRREPVGGDGNGGGTGVLWNLATPGRRYRVFEAAPQGTRGMPAKKPVGEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z0X2</accession>
    <name>A0A0D1Z0X2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_01871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847492">
        <property type="protein sequence ID" value="KIW21291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016241507.1">
        <property type="nucleotide sequence ID" value="XM_016376231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z0X2"/>
    <dbReference type="STRING" id="91928.A0A0D1Z0X2"/>
    <dbReference type="GeneID" id="27328954"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_01871"/>
    <dbReference type="HOGENOM" id="CLU_440742_0_0_1"/>
    <dbReference type="OrthoDB" id="4159993at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW21291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="596" mass="62681" checksum="7753D15106A55F3E" modified="2015-04-29" version="1">MFRHAVLLNRRDPQNLSDLPASIGNPTSTLPQSIAATGVVTTDPSATAPLVTAQAPSGLTTITETETLARSISGLDTVSTTITTKTRTITDPSEYASLTSAAALSASTRVSTTSSKTSAAATSSAAAQKSSSSNTSTLIPAIVVPIVVVLLASLGVFWFLMRRRHRRELKSQPEFVMAGKGEKLSSRSNSGRSTSSAAESEKKGPVTQAKELSTKSPPMASMSEWPSTQIGLARPLTPQETKNANLGPAGRSLDQARPGPAPAERPYRNFSGPGPRPPTANRAGPQSSARELPQQRDRGYSNPNQRGPPPPRTGPSPIPRASPNLNPRGGPSPVPQRPSPSMSQQPFRNDRRGDASPASAAFRLRDPSPGMNHNTRAQAPARLAAAPPTGAYNGASSISQYSPIVKDSPGPARPPPTTKRGPPPPLKTDLASRRADRSPNSASPGALTEENMRIARLANSSRLGYTPAEPSPSPKLPPPATRSQLIPRESPKDKPENYFGGSVVGSLPQSRQVSTSYHSDRASIVSDPDEYEDIDAKSDVSSLNEFERFDFGPTAGGSRGGGSAAGHSLNYFAAQNSPSAGRGSPFGDNDTTYERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1Z9P0</accession>
    <name>A0A0D1Z9P0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_12035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847504">
        <property type="protein sequence ID" value="KIW09692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016229908.1">
        <property type="nucleotide sequence ID" value="XM_016386342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1Z9P0"/>
    <dbReference type="GeneID" id="27339118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_12035"/>
    <dbReference type="HOGENOM" id="CLU_025453_0_0_1"/>
    <dbReference type="OrthoDB" id="4161789at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW09692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="75596" checksum="D42E37063E8148C2" modified="2015-04-29" version="1">MAMGTSWPSLGAEPHDLKEHVTFLHEACAQLHAVKHSHTAIPTTTIGPIIDSTLSLLSKITRHLDEQPDTRLASQIQDLFKEQRDAQLKDHEAIKAVIKAATAPLNTATPPSGTHVASWAQVAAAAGPPPGHVTPPHTVLSSGSPSTLTAYKGREVIVKLLDHALAQRLRQLSPSQLKNKVNNILRDTPKVRDIKVAAAHQLKSGDITVITNSLDEATELQIHTDWARGLGPRAEVIRTTYGAIVHGIPVDTINMNDQQGTIQRVLADNFSVIPHAKITYVGWLTKGSTKKRNSSIVIEFTQPEMANAIIYAGFLWEGLIHNCQLYDRSCRIKQCLRCYDYGHIGTQCNAPQKCGHCAGGHESRGCPVKGGPGFQPKCALCGGDHTAWNAACLARQKEMQRVERAKQARSHYWPAPSRRTAPATSSHNEPGPPLPTSTSDNPDEPARRSHPDGLSNQAIREPRVLRSSRRQQQSNATLPTAHLRISHSETTVPSQQTASHVPAAPATVLEEPPVSQEPTAPTHYPPVPLAEDFPGADDWLQNLDFNWEDTIAVDPTPGISTIPNSQYHARTLSPRELARLERAVVTFDDLPPPRRGCYCEEHEHIYENWPVRDAELIIGTCMRECPYCSYRQESTPELRKHIRGRHGRRNLTVRKGKLGDKRVAPGWIALPTTQTRQTQGTAPHTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZAQ2</accession>
    <name>A0A0D1ZAQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_11052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230308.1">
        <property type="nucleotide sequence ID" value="XM_016385364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZAQ2"/>
    <dbReference type="STRING" id="91928.A0A0D1ZAQ2"/>
    <dbReference type="GeneID" id="27338135"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11052"/>
    <dbReference type="HOGENOM" id="CLU_1354638_0_0_1"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KIW10092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22047" checksum="E5751C60FE6F18B9" modified="2015-04-29" version="1">MDMLQFCDVAGANWYFQHRGDLWNEFCHLATAPSTGIGIGGQPAKIIWGADVVSVNVDSGEVKLADGTIIASDLVIAADGIKSIIRPLVTGEEAFRTARPSGTSAFRFIMPVVGPFASVQPRCSRRPERIESFCSYTLGSGSKRPSLGPPMVRQKIFWTLPILERAEGVKLWQLRDLNCANIFILSATSRVPHISINMTLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZC13</accession>
    <name>A0A0D1ZC13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_11476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230728.1">
        <property type="nucleotide sequence ID" value="XM_016385784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZC13"/>
    <dbReference type="STRING" id="91928.A0A0D1ZC13"/>
    <dbReference type="GeneID" id="27338559"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11476"/>
    <dbReference type="HOGENOM" id="CLU_029537_0_2_1"/>
    <dbReference type="OrthoDB" id="4605274at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053228">
        <property type="entry name" value="Stereospecific_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574:SF1">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW10512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40850" checksum="1D26F344CFF43E22" modified="2015-04-29" version="1">MFRSKKVNINSYQNKNPDPPVSVYQALESGDAPYALTEDALRSVMFIPAEFNHGKDGKTPVILVPGTGSYGGEAYEHNFAKLLRGTSFADPVWLNIPGRMCDEAPKNAEHVAYAINYLATLCSTKVAVVAWSQGNLSTQWALKYWPSTRTRVSNFICLSADFRGTVQAWGLAPCPYTVPGTPAVWNQTRNSKFIATLRSNGGDSAYVPTTSIYSSTDEVVQPQFGPFASAFMRDERNVGVTNCEIQHAAVRFMKPGQLAYSHEGVMHSSLAWALAEDALRNGGPGRLDRIDMAGVCKSRIAPGLSILDATQTQALSAWCLKSILLFTPKPWHEPALPLYVASEEVDYVPEDDVQPVKQEVQIAETEVVASPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZC91</accession>
    <name>A0A0D1ZC91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PV08_11606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847500">
        <property type="protein sequence ID" value="KIW10642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016230858.1">
        <property type="nucleotide sequence ID" value="XM_016385914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZC91"/>
    <dbReference type="STRING" id="91928.A0A0D1ZC91"/>
    <dbReference type="GeneID" id="27338689"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_11606"/>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF132">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KIW10642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="344" mass="38401" checksum="A6389EFC8589A910" modified="2015-04-29" version="1">MALERGMQAVVTAAVFNALAFLFIVARCVSRFIILKQAGPEDYLILFALALSIGLTVIIILEKNSGLGRHADTVSAEDNETLLKLLYASVIEYNVALFLLKDSILYQYLRFFVQRSYRIAAWCLIGIVGVGGFAFILMSCFSCWPIAYFWEKSIENGHCVDILAFWFSFSAFNIATDLAVWFLPMPVLYNLKLPRKQKMTLIAVFALGGFGCITSFLRLHALYVTSVSTDLTYDNVDAATWSAAELNVGIMCACIPAIRPVVSLLFPRLLTSTRRSRTSDAYQRGTSGFRNDDMVPLSHALSQANKVPRSDTTSQEERSSLDPTNVSNTIHVKQEWTITEHEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZD37</accession>
    <name>A0A0D1ZD37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PV08_10206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 89968</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW10907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231123.1">
        <property type="nucleotide sequence ID" value="XM_016384521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZD37"/>
    <dbReference type="STRING" id="91928.A0A0D1ZD37"/>
    <dbReference type="GeneID" id="27337289"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10206"/>
    <dbReference type="HOGENOM" id="CLU_016216_2_0_1"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KIW10907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="693" mass="75207" checksum="76317610AA175A29" modified="2015-04-29" version="1">MAARGQTLRDRQIASIERILSLNHDEVLEAANGTTDTKNLSAASLLNENGEPIWKVLVFDNLGRDVISSVLRVNDLRSKGVTIHLNINSPRYPIPDVPVLYLVEPTAVNIQLICSDLARGLYSPAYVNFLSSIPRPLLEDFAAQISSTNTADAIAQVYDQYLNFIVAEPDLFSLGMGKESYWTFNSAKAEADIQDAAIDRIVSGLFSVSVTMGSVPIIRCPQSELAKMIASKLDRKLRDHVLNSKDNLFSSKAAGNVYSTPSRPVLIILDRNVDLVPMLSHSWTYQSLVHDVLKMHLNRITVDVAEEGTAAPKTKAYDLNASDFFWARNASAPFPQVAEDIDSELTKYKTDAEEVTKKTGVNSIEDLNDSSASAAHLKAAITLLPELRERKATLDMHMNIATALLKGIKDRQLDNFFQLEENITKQTAEQMLALIKSEDKGNNPLDKLRIFIIWYLSVDKEPTKSELSEFESALTAAGVGDAVVAIKHISNVRLETRGTMMASTVTTSQPSQAPLFGGLSSLSKNFTDKLSSSALGNVNLDALVSGVKNFLPANKDLTVTKIVESIMDPPAASSSAIAKTENYLYFDPRSAHARGTTGGSAPASRGGQGAGGVNPSFGQRRQGYSEAIVFTVGGGSMDEYGNLQEWVKRTSGQNAAGGSVGSAPRTRRVIYGSTELVNGEDFLQELVRLGQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZDP4</accession>
    <name>A0A0D1ZDP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PV08_10412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 89968</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN847499">
        <property type="protein sequence ID" value="KIW11112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231328.1">
        <property type="nucleotide sequence ID" value="XM_016384726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZDP4"/>
    <dbReference type="GeneID" id="27337495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_10412"/>
    <dbReference type="HOGENOM" id="CLU_041456_0_0_1"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000021">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="7">
        <location>
            <begin position="35"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KIW11112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="239" mass="26644" checksum="DA72E05076BD0B0E" modified="2015-04-29" version="1">MPPRAKQKNALHPKPGPSTGITAPNWPPLTPVIPADHLSIETVLDGQILVIRNLFTSTLCKNYVAFLASLPLTTTPGKPKRGEAVRVNDRFQIEDPIFAKTLWESSGLKSLVESFGDTKAFDGKILGLNSNIRVYRYRPGQFFDKHYDESNKIHFGEDKVPAKTTWTLLIYLTTCQGGETAFYPEPSKRGVPPPEPIVIGLETGMALLHKHGDDCLFHEGKEVRSGEKWVLRSDLVVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZFI7</accession>
    <name>A0A0D1ZFI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PV08_09034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847498">
        <property type="protein sequence ID" value="KIW11762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016231978.1">
        <property type="nucleotide sequence ID" value="XM_016383355.1"/>
    </dbReference>
    <dbReference type="STRING" id="91928.A0A0D1ZFI7"/>
    <dbReference type="GeneID" id="27336117"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_09034"/>
    <dbReference type="HOGENOM" id="CLU_008198_0_0_1"/>
    <dbReference type="OrthoDB" id="4121247at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clr5" evidence="5">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="604"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="689"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="838"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1073"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1108"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1143"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KIW11762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="1339" mass="144871" checksum="B75DE61B116786D5" modified="2015-04-29" version="1">MTAVKSIPSEIISTMGRGRPPSGPQHDDWEAKRNIIERLYISEGKSLKTVQAIMLAEHHFSATFVFWISHILTLLNFHSKSQYEMRFNDWGLRKKVKHRDWIDIDCYVQRRKRLGVDSDVYIDGILIPPKKLRKKARRNDTSAVTTFQQEPHSPELPNRVSILTPQPCQLLAPPIEQLPWALFSASLEAQCRSRFGDILYRVLMLLLAYDALLNPQHQSSSAGGHHDQMTNQSLPFASTSYLYSTFFRSLFPFCSGVDTSQQINMISALLPITASLDTPQGQDFCSLTIHNANIQLLMLLTFSLSNNLLTNYDIDLLLKLVPPPSRLSLLRDLVSHKGAATEGVTERLFEYAILCDTQMLSMLLGLGIDPNEQVVSWLGALTTPLAYAANFAKKEAVKVLISEGADVNGTHSFIKDGGRPIEKAVECGAWATAQLLLNHGAKVDGSYRSRTGASMLECAFRDYRAPDPCLIKALLDNGVSMGLDGHQCAKILALALPYSLDTNDVSWQETIHHLLQAGVKAAAEPVSIEASMLDDDGELLCFPTPLSILERAADLGDTNTFLLLHEAGARITRFTLYYAAGNGNEALVKFLLGKGVNPNEQFPSGDCALLVAASSDSPSHKSILRLLVDSGANVNPERPLMNQSPPIWTPLQAASYAGNILEVELLLRHQADIHADAGVQNFDNPALAESFTALSAAAYEGHTGIVRRLLEAGAKVGQPASPLALSAAARSDDRESLGLILEAGADINASMGTYPNPLNTATLLSSRQTVEWLLSHGAKADVTGGNHPSAIQAAIIRSADGFDDLIQSLISAGGDVNAAEGHVGVDENFDYYNDRPKKWHTPLVLAIKQNRPGIVDLLLSKGANANDLSGLSYSTTALEAAASQANLGLVFRLLRAGAETDDPEALLAAVRTRRGQDVAGALLTAHSIRYHGLRKHFGGLALQYTIAHGDLTLMKQLIDAGIDVNAVVRRSDGRRAIVRNWDCSTFEERYEIRDGESPLGTAVRSFLGHTAAVSLLLQHGANPNSFVVGTRVYDDGTRQTVLVAAIATRNEELVKMLVAAGADVNWCLLTDERARTPLQEAAGAGLLSIVRALIEAGARVNNEGASSGGVTALQAAAIGGHVNVARLLIELGAQVDAPRAPTDGRTALEGAAEHGRIDMVQLLLNSGAEIDEYDPEGQYRRALDFSYREGHLATWRLLKRSCEWTDNVNPSTSFAYAAGGANGTSVTNLVNEQEEVPDSAPTVSLFGNQVTLSEPVPVQTQEGLLHEILDGHALGATGVSTAAPEGPWPYLDDQEASSVSLPDPTFPWSADWTNFQDGSFVGDEDRYAFEIGENFMSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZIZ5</accession>
    <name>A0A0D1ZIZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PV08_08024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW12837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233053.1">
        <property type="nucleotide sequence ID" value="XM_016382350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZIZ5"/>
    <dbReference type="GeneID" id="27335107"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08024"/>
    <dbReference type="HOGENOM" id="CLU_144977_0_0_1"/>
    <dbReference type="OrthoDB" id="4116811at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011431">
        <property type="entry name" value="Trafficking_Pga2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07543">
        <property type="entry name" value="PGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KIW12837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="162" mass="17346" checksum="E01EC04E47F36DF7" modified="2015-04-29" version="1">MSSDLLRRLDALVDSAASSLPPQAQAYLTRTNLQSFLRIVVIVATYLLFRPHLETLFRKITGTPDKRQEEIKARIEFLQQQQQQEAAAMFGGKIPVLNKEGKILKLVTPEEAETLKRQGAAVDGPTGSTGTGTGTGTSANGPTSAGGNGGKPKKKAKTKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZJR0</accession>
    <name>A0A0D1ZJR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PV08_08219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 89968</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN847497">
        <property type="protein sequence ID" value="KIW13032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016233248.1">
        <property type="nucleotide sequence ID" value="XM_016382545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZJR0"/>
    <dbReference type="STRING" id="91928.A0A0D1ZJR0"/>
    <dbReference type="GeneID" id="27335302"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_08219"/>
    <dbReference type="HOGENOM" id="CLU_1927614_0_0_1"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KIW13032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="131" mass="14870" checksum="EFA637D811ECFFE6" modified="2015-04-29" version="1">MSHKSRWDYRAITMFIPDAAVRVTPKDLHDKTAFIDAARPEGLFLTRNQFRLWSQLRSPNFQSGDRVLVCLQETRSPPPLPSWVSSWQAASSLERILALLRGELANQLRDSGSTYLLCSHQSIETGVRATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZMK7</accession>
    <name>A0A0D1ZMK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PV08_06798</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Exophiala spinifera CBS89968.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="de Hoog S."/>
                <person name="Gorbushina A."/>
                <person name="Stielow B."/>
                <person name="Teixiera M."/>
                <person name="Abouelleil A."/>
                <person name="Chapman S.B."/>
                <person name="Priest M."/>
                <person name="Young S.K."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 89968</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN847496">
        <property type="protein sequence ID" value="KIW14017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016234233.1">
        <property type="nucleotide sequence ID" value="XM_016381131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D1ZMK7"/>
    <dbReference type="STRING" id="91928.A0A0D1ZMK7"/>
    <dbReference type="GeneID" id="27333881"/>
    <dbReference type="VEuPathDB" id="FungiDB:PV08_06798"/>
    <dbReference type="HOGENOM" id="CLU_010811_4_1_1"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000053328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="254"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KIW14017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053328"/>
        </source>
    </evidence>
    <sequence length="631" mass="69857" checksum="C05FFF6BB04B3B39" modified="2015-04-29" version="1">MSSQSNSSNSPPPRVPPHIRLNSGQEDLVAADSNSSSRTLVPTTSRPGASPRLNNIYTGDTLRDSSERLLPPGRGRFQNDGSQSPLRSPSSFSSRRSSWESDRSRDSRGFENPFRDSSQSRPGSRAGSEDNDVNTQTVSEKYNILPSAGLLLFPEDVEKDDYLHNPDPEGEPRDCDIFTKRGLVNVGGLAFIVIGILVLFIGYPVLTFVQEATKTYDPCQEGIGCVGTGKLPLLTNMRTGLIDPDTPESVKTKKDFHGNTWNLVFSDEFSKPGRTFYEGDDPYWTAVDIWYGVTRDLEWYDPDAATTNDGVLELRFDAFQNHGLNYRSGMLQSWNQLCFKGGRLEASISLPGRGDTVGFWPGFWSMGNLGRPGYAATTDGLWPYSYDDVCDAGITPNQSSPDGINYLPGMRLPACTCKGEDHPSPGNSRSAPEIDVLEATVGTLDEEGNQIGMVSQSYQVAPFDIWYQPNYDFVEVYDFSVTAMNTYKGAPLQQAFSGISNLNNQWYDGNAYQVYAYEYTPGAQGEIIWYVGSDPVWRLKGEALAPNGNIAQRPIPQEPLSIIVNFGMSPGFSALNLTGLASLMPAKMRIDYIRIYQDDSGEMSCDPEGYPTTEYINNHYDVYHNPNITLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D1ZUM6</accession>
    <name>A0A0D1ZUM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PV08_06505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Exophiala spinifera</name>
        <dbReference type="NCBI Taxonomy" id="91928"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Exophiala</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
  
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